##gff-version 3
#!gff-spec-version 1.21
#!processor NCBI annotwriter
#!genome-build ASM19595v2
#!genome-build-accession NCBI_Assembly:GCA_000195955.2
##sequence-region AL123456.3 1 4411532
##species https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=83332
AL123456.3	EMBL	region	1	4411532	.	+	.	ID=AL123456.3:1..4411532;Dbxref=taxon:83332;gbkey=Src;mol_type=genomic DNA;strain=H37Rv;type-material=type strain of Mycobacterium tuberculosis
AL123456.3	EMBL	gene	1	1524	.	+	.	ID=gene-Rv0001;Name=dnaA;gbkey=Gene;gene=dnaA;gene_biotype=protein_coding;locus_tag=Rv0001
AL123456.3	EMBL	CDS	1	1524	.	+	0	ID=cds-CCP42723.1;Parent=gene-Rv0001;Dbxref=EnsemblGenomes-Gn:Rv0001,EnsemblGenomes-Tr:CCP42723,GOA:P9WNW3,InterPro:IPR001957,InterPro:IPR003593,InterPro:IPR010921,InterPro:IPR013159,InterPro:IPR013317,InterPro:IPR018312,InterPro:IPR020591,InterPro:IPR027417,NCBI_GP:CCP42723.1;Name=CCP42723.1;Note=Rv0001%2C (MT0001%2C MTV029.01%2C P49993)%2C len: 507 aa. dnaA%2C chromosomal replication initiator protein (see citations below)%2C equivalent to other Mycobacterial chromosomal replication initiator proteins. Also highly similar to others except in N-terminus e.g. Q9ZH75|DNAA_STRCH chromosomal replication initiator protein from Streptomyces chrysomallus (624 aa). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS01008 DnaA protein signature. Belongs to the DnaA family. Note that the first base of this gene has been taken as base 1 of the Mycobacterium tuberculosis H37Rv genomic sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaA;inference=protein motif:PROSITE:PS01008;locus_tag=Rv0001;product=Chromosomal replication initiator protein DnaA;protein_id=CCP42723.1;transl_table=11
AL123456.3	EMBL	gene	2052	3260	.	+	.	ID=gene-Rv0002;Name=dnaN;gbkey=Gene;gene=dnaN;gene_biotype=protein_coding;locus_tag=Rv0002
AL123456.3	EMBL	CDS	2052	3260	.	+	0	ID=cds-CCP42724.1;Parent=gene-Rv0002;Dbxref=EnsemblGenomes-Gn:Rv0002,EnsemblGenomes-Tr:CCP42724,GOA:P9WNU1,InterPro:IPR001001,InterPro:IPR022634,InterPro:IPR022635,InterPro:IPR022637,PDB:3P16,PDB:3RB9,NCBI_GP:CCP42724.1;Name=CCP42724.1;Note=Rv0002%2C (MTV029.02%2C MTCY10H4.0)%2C len: 402 aa. DnaN%2CDNA polymerase III (beta chain) (see citations below)%2Cequivalent to other Mycobacterial DNA polymerases III beta chain. Also highly similar to others e.g. P27903|DP3B_STRCO DNA polymerase III beta chain from Streptomyces coelicolor (376 aa). Overlaps and extends CDS in neighbouring cosmid MTCY10H4.01.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaN;locus_tag=Rv0002;product=DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase);protein_id=CCP42724.1;transl_table=11
AL123456.3	EMBL	gene	3280	4437	.	+	.	ID=gene-Rv0003;Name=recF;gbkey=Gene;gene=recF;gene_biotype=protein_coding;locus_tag=Rv0003
AL123456.3	EMBL	CDS	3280	4437	.	+	0	ID=cds-CCP42725.1;Parent=gene-Rv0003;Dbxref=EnsemblGenomes-Gn:Rv0003,EnsemblGenomes-Tr:CCP42725,GOA:P9WHI9,InterPro:IPR001238,InterPro:IPR003395,InterPro:IPR018078,InterPro:IPR027417,NCBI_GP:CCP42725.1;Name=CCP42725.1;Note=Rv0003%2C (MTCY10H4.01)%2C len: 385 aa. RecF%2C DNA replication and repair protein (see citations below)%2Cequivalent to other mycobacterial DNA replication and repair proteins. Also highly similar to many others. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2CPS00617 RecF protein signature 1%2C and PS00618 RecF protein signature 2. Belongs to the RecF family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recF;inference=protein motif:PROSITE:PS00618;locus_tag=Rv0003;product=DNA replication and repair protein RecF (single-strand DNA binding protein);protein_id=CCP42725.1;transl_table=11
AL123456.3	EMBL	gene	4434	4997	.	+	.	ID=gene-Rv0004;Name=Rv0004;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0004
AL123456.3	EMBL	CDS	4434	4997	.	+	0	ID=cds-CCP42726.1;Parent=gene-Rv0004;Dbxref=EnsemblGenomes-Gn:Rv0004,EnsemblGenomes-Tr:CCP42726,InterPro:IPR007922,InterPro:IPR023007,NCBI_GP:CCP42726.1;Name=CCP42726.1;Note=Rv0004%2C (MTCY10H4.02)%2C len: 187 aa. Conserved hypothetical protein (see Salazar et al.%2C 1996). Belongs to superfamily DUF721%3B this family contains several actinomycete proteins of unknown function.;gbkey=CDS;locus_tag=Rv0004;product=Conserved hypothetical protein;protein_id=CCP42726.1;transl_table=11
AL123456.3	EMBL	gene	5240	7267	.	+	.	ID=gene-Rv0005;Name=gyrB;gbkey=Gene;gene=gyrB;gene_biotype=protein_coding;locus_tag=Rv0005
AL123456.3	EMBL	CDS	5240	7267	.	+	0	ID=cds-CCP42727.1;Parent=gene-Rv0005;Dbxref=EnsemblGenomes-Gn:Rv0005,EnsemblGenomes-Tr:CCP42727,GOA:P9WG45,InterPro:IPR001241,InterPro:IPR002288,InterPro:IPR003594,InterPro:IPR006171,InterPro:IPR011557,InterPro:IPR013506,InterPro:IPR013759,InterPro:IPR013760,InterPro:IPR014721,InterPro:IPR018522,InterPro:IPR020568,PDB:2ZJT,PDB:3IG0,PDB:3M4I,PDB:3ZKB,PDB:3ZKD,PDB:3ZM7,NCBI_GP:CCP42727.1;Name=CCP42727.1;Note=Rv0005%2C (MTCY10H4.03)%2C len: 675 aa. GyrB%2C DNA gyrase subunit B (see citations below). Contains PS00177 DNA topoisomerase II signature. Belongs to the type II topoisomerase family. Start changed since first submission (-39 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gyrB;inference=protein motif:PROSITE:PS00177;locus_tag=Rv0005;product=DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase);protein_id=CCP42727.1;transl_table=11
AL123456.3	EMBL	gene	7302	9818	.	+	.	ID=gene-Rv0006;Name=gyrA;gbkey=Gene;gene=gyrA;gene_biotype=protein_coding;locus_tag=Rv0006
AL123456.3	EMBL	CDS	7302	9818	.	+	0	ID=cds-CCP42728.1;Parent=gene-Rv0006;Dbxref=EnsemblGenomes-Gn:Rv0006,EnsemblGenomes-Tr:CCP42728,GOA:P9WG47,InterPro:IPR002205,InterPro:IPR005743,InterPro:IPR006691,InterPro:IPR013758,InterPro:IPR013760,InterPro:IPR024946,PDB:3IFZ,PDB:3ILW,PDB:3UC1,PDB:4G3N,NCBI_GP:CCP42728.1;Name=CCP42728.1;Note=Rv0006%2C (MTCY10H4.04)%2C len: 838 aa. GyrA%2C DNA gyrase subunit A (see citations below). Contains PS00018 EF-hand calcium-binding domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gyrA;inference=protein motif:PROSITE:PS00018;locus_tag=Rv0006;product=DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase);protein_id=CCP42728.1;transl_table=11
AL123456.3	EMBL	gene	9914	10828	.	+	.	ID=gene-Rv0007;Name=Rv0007;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0007
AL123456.3	EMBL	CDS	9914	10828	.	+	0	ID=cds-CCP42729.1;Parent=gene-Rv0007;Dbxref=EnsemblGenomes-Gn:Rv0007,EnsemblGenomes-Tr:CCP42729,GOA:P9WMA7,InterPro:IPR021949,NCBI_GP:CCP42729.1;Name=CCP42729.1;Note=Rv0007%2C (MTCY10H4.05)%2C len: 304 aa. Possible conserved membrane protein. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0007;product=Possible conserved membrane protein;protein_id=CCP42729.1;transl_table=11
AL123456.3	EMBL	gene	10887	10960	.	+	.	ID=gene-ileT;Name=ileT;gbkey=Gene;gene=ileT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	10887	10960	.	+	.	ID=rna-ileT;Parent=gene-ileT;Note=codon recognized: AUC%3B ileT%2C tRNA-Ile%2C anticodon gat%2C length %3D 74;anticodon=(pos:10921..10923);gbkey=tRNA;gene=ileT;product=tRNA-Ile
AL123456.3	EMBL	exon	10887	10960	.	+	.	ID=exon-ileT-1;Parent=rna-ileT;Note=codon recognized: AUC%3B ileT%2C tRNA-Ile%2C anticodon gat%2C length %3D 74;anticodon=(pos:10921..10923);gbkey=tRNA;gene=ileT;product=tRNA-Ile
AL123456.3	EMBL	gene	11112	11184	.	+	.	ID=gene-alaT;Name=alaT;gbkey=Gene;gene=alaT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	11112	11184	.	+	.	ID=rna-alaT;Parent=gene-alaT;Note=codon recognized: GCA%3B alaT%2C tRNA-Ala%2C anticodon tgc%2C length %3D 73;anticodon=(pos:11145..11147);gbkey=tRNA;gene=alaT;product=tRNA-Ala
AL123456.3	EMBL	exon	11112	11184	.	+	.	ID=exon-alaT-1;Parent=rna-alaT;Note=codon recognized: GCA%3B alaT%2C tRNA-Ala%2C anticodon tgc%2C length %3D 73;anticodon=(pos:11145..11147);gbkey=tRNA;gene=alaT;product=tRNA-Ala
AL123456.3	EMBL	gene	11874	12311	.	-	.	ID=gene-Rv0008c;Name=Rv0008c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0008c
AL123456.3	EMBL	CDS	11874	12311	.	-	0	ID=cds-CCP42730.1;Parent=gene-Rv0008c;Dbxref=EnsemblGenomes-Gn:Rv0008c,EnsemblGenomes-Tr:CCP42730,GOA:P9WJF3,InterPro:IPR024245,NCBI_GP:CCP42730.1;Name=CCP42730.1;Note=Rv0008c%2C (MTCY10H4.07c)%2C len: 145 aa. Possible membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0008c;product=Possible membrane protein;protein_id=CCP42730.1;transl_table=11
AL123456.3	EMBL	gene	12468	13016	.	+	.	ID=gene-Rv0009;Name=ppiA;gbkey=Gene;gene=ppiA;gene_biotype=protein_coding;gene_synonym=cfp22;locus_tag=Rv0009
AL123456.3	EMBL	CDS	12468	13016	.	+	0	ID=cds-CCP42731.1;Parent=gene-Rv0009;Dbxref=EnsemblGenomes-Gn:Rv0009,EnsemblGenomes-Tr:CCP42731,GOA:P9WHW3,InterPro:IPR002130,InterPro:IPR020892,InterPro:IPR024936,InterPro:IPR029000,PDB:1W74,NCBI_GP:CCP42731.1;Name=CCP42731.1;Note=Rv0009%2C (MTCY10H4.08)%2C len: 182 aa. Probable ppiA (alternate gene name: cfp22)%2C iron-regulated peptidyl-prolyl cis-trans isomerase A. Belongs to the cyclophilin-type PPIase family. Alternative start codon has been suggested.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppiA;locus_tag=Rv0009;product=Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A);protein_id=CCP42731.1;transl_table=11
AL123456.3	EMBL	gene	13133	13558	.	-	.	ID=gene-Rv0010c;Name=Rv0010c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0010c
AL123456.3	EMBL	CDS	13133	13558	.	-	0	ID=cds-CCP42732.1;Parent=gene-Rv0010c;Dbxref=EnsemblGenomes-Gn:Rv0010c,EnsemblGenomes-Tr:CCP42732,GOA:P9WMA3,InterPro:IPR019692,NCBI_GP:CCP42732.1;Name=CCP42732.1;Note=Rv0010c%2C (MTCY10H4.10c)%2C len: 141 aa. Probable conserved membrane protein. Belongs to superfamily DUF2581%2Cconserved in the Actinomycetales. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0010c;product=Probable conserved membrane protein;protein_id=CCP42732.1;transl_table=11
AL123456.3	EMBL	gene	13714	13995	.	-	.	ID=gene-Rv0011c;Name=Rv0011c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0011c
AL123456.3	EMBL	CDS	13714	13995	.	-	0	ID=cds-CCP42733.1;Parent=gene-Rv0011c;Dbxref=EnsemblGenomes-Gn:Rv0011c,EnsemblGenomes-Tr:CCP42733,GOA:P9WP57,InterPro:IPR009619,NCBI_GP:CCP42733.1;Name=CCP42733.1;Note=Rv0011c%2C (MTCY10H4.11c)%2C len: 93 aa. Probable conserved transmembrane protein. Belongs to uncharacterized protein family UPF0233. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0011c;product=Probable conserved transmembrane protein;protein_id=CCP42733.1;transl_table=11
AL123456.3	EMBL	gene	14089	14877	.	+	.	ID=gene-Rv0012;Name=Rv0012;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0012
AL123456.3	EMBL	CDS	14089	14877	.	+	0	ID=cds-CCP42734.1;Parent=gene-Rv0012;Dbxref=EnsemblGenomes-Gn:Rv0012,EnsemblGenomes-Tr:CCP42734,InterPro:IPR010273,UniProtKB/TrEMBL:L0T243,NCBI_GP:CCP42734.1;Name=CCP42734.1;Note=Rv0012%2C (MTCY10H4.12)%2C len: 262 aa. Probable conserved membrane protein. Belongs to superfamily DUF881. Contains probable N-terminal signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0012;product=Probable conserved membrane protein;protein_id=CCP42734.1;transl_table=11
AL123456.3	EMBL	gene	14914	15612	.	+	.	ID=gene-Rv0013;Name=trpG;gbkey=Gene;gene=trpG;gene_biotype=protein_coding;gene_synonym=pabA;locus_tag=Rv0013
AL123456.3	EMBL	CDS	14914	15612	.	+	0	ID=cds-CCP42735.1;Parent=gene-Rv0013;Dbxref=EnsemblGenomes-Gn:Rv0013,EnsemblGenomes-Tr:CCP42735,GOA:P9WN35,InterPro:IPR006221,InterPro:IPR017926,InterPro:IPR029062,NCBI_GP:CCP42735.1;Name=CCP42735.1;Note=Rv0013%2C (MTCY10H4.13)%2C len: 232 aa. Possible trpG%2Canthranilate synthase component II (glutamine amidotransferase). Contains PS00606 Beta-ketoacyl synthases active site%3B and PS00442 Glutamine amidotransferases class-I active site. Similarity to other type-1 glutamine amidotransferase domains. Note that previously known as pabA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trpG;inference=protein motif:PROSITE:PS00606;locus_tag=Rv0013;product=Possible anthranilate synthase component II TrpG (glutamine amidotransferase);protein_id=CCP42735.1;transl_table=11
AL123456.3	EMBL	gene	15590	17470	.	-	.	ID=gene-Rv0014c;Name=pknB;gbkey=Gene;gene=pknB;gene_biotype=protein_coding;locus_tag=Rv0014c
AL123456.3	EMBL	CDS	15590	17470	.	-	0	ID=cds-CCP42736.1;Parent=gene-Rv0014c;Dbxref=EnsemblGenomes-Gn:Rv0014c,EnsemblGenomes-Tr:CCP42736,GOA:P9WI81,InterPro:IPR000719,InterPro:IPR002290,InterPro:IPR005543,InterPro:IPR008271,InterPro:IPR011009,InterPro:IPR017441,PDB:1MRU,PDB:1O6Y,PDB:2FUM,PDB:2KUD,PDB:2KUE,PDB:2KUF,PDB:2KUI,PDB:3F61,PDB:3F69,NCBI_GP:CCP42736.1;Name=CCP42736.1;Note=Rv0014c%2C (MTCY10H4.14c)%2C len: 626 aa. PknB%2Ctransmembrane serine/threonine-protein kinase (see citations below). Contains PS00107 Protein kinases ATP-binding region signature%2C and PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation on serine/threonine residues. PknB has been shown to be a substrate for PstP and its kinase activity is affected by PstP-mediated dephosphorylation. PknB and PstP (Rv0018c) may act as a functional pair in vivo to control mycobacterial cell growth.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknB;inference=protein motif:PROSITE:PS00108;locus_tag=Rv0014c;product=Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B);protein_id=CCP42736.1;transl_table=11
AL123456.3	EMBL	gene	17467	18762	.	-	.	ID=gene-Rv0015c;Name=pknA;gbkey=Gene;gene=pknA;gene_biotype=protein_coding;locus_tag=Rv0015c
AL123456.3	EMBL	CDS	17467	18762	.	-	0	ID=cds-CCP42737.1;Parent=gene-Rv0015c;Dbxref=EnsemblGenomes-Gn:Rv0015c,EnsemblGenomes-Tr:CCP42737,GOA:P9WI83,InterPro:IPR000719,InterPro:IPR008271,InterPro:IPR011009,NCBI_GP:CCP42737.1;Name=CCP42737.1;Note=Rv0015c%2C (MTCY10H4.15c)%2C len: 431 aa. PknA%2Ctransmembrane serine/threonine-protein kinase%2Cmagnesium/manganese dependent (see citations below). Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases. It has been shown that sodium orthovanadate inhibits the activity of the enzyme in vitro.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknA;inference=protein motif:PROSITE:PS00108;locus_tag=Rv0015c;product=Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A);protein_id=CCP42737.1;transl_table=11
AL123456.3	EMBL	gene	18759	20234	.	-	.	ID=gene-Rv0016c;Name=pbpA;gbkey=Gene;gene=pbpA;gene_biotype=protein_coding;locus_tag=Rv0016c
AL123456.3	EMBL	CDS	18759	20234	.	-	0	ID=cds-CCP42738.1;Parent=gene-Rv0016c;Dbxref=EnsemblGenomes-Gn:Rv0016c,EnsemblGenomes-Tr:CCP42738,GOA:P9WKD1,InterPro:IPR001460,InterPro:IPR012338,PDB:3LO7,PDB:3UN7,PDB:3UPN,PDB:3UPO,PDB:3UPP,NCBI_GP:CCP42738.1;Name=CCP42738.1;Note=Rv0016c%2C (MTCY10H4.16c)%2C len: 491 aa. Probable pbpA%2Cpenicillin-binding protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pbpA;locus_tag=Rv0016c;product=Probable penicillin-binding protein PbpA;protein_id=CCP42738.1;transl_table=11
AL123456.3	EMBL	gene	20231	21640	.	-	.	ID=gene-Rv0017c;Name=rodA;gbkey=Gene;gene=rodA;gene_biotype=protein_coding;gene_synonym=ftsW;locus_tag=Rv0017c
AL123456.3	EMBL	CDS	20231	21640	.	-	0	ID=cds-CCP42739.1;Parent=gene-Rv0017c;Dbxref=EnsemblGenomes-Gn:Rv0017c,EnsemblGenomes-Tr:CCP42739,GOA:P9WN99,InterPro:IPR001182,InterPro:IPR018365,NCBI_GP:CCP42739.1;Name=CCP42739.1;Note=Rv0017c%2C (MTCY10H4.17c)%2C len: 469 aa. Probable rodA (alternate gene name: ftsW)%2C cell division protein%2Cintegral membrane protein. Belongs to the FTSW/RODA/SPOVE family.;gbkey=CDS;gene=rodA;locus_tag=Rv0017c;product=Probable cell division protein RodA;protein_id=CCP42739.1;transl_table=11
AL123456.3	EMBL	gene	21637	23181	.	-	.	ID=gene-Rv0018c;Name=pstP;gbkey=Gene;gene=pstP;gene_biotype=protein_coding;locus_tag=Rv0018c
AL123456.3	EMBL	CDS	21637	23181	.	-	0	ID=cds-CCP42740.1;Parent=gene-Rv0018c;Dbxref=EnsemblGenomes-Gn:Rv0018c,EnsemblGenomes-Tr:CCP42740,GOA:P9WHW5,InterPro:IPR001932,InterPro:IPR015655,PDB:1TXO,PDB:2CM1,NCBI_GP:CCP42740.1;Name=CCP42740.1;Note=Rv0018c%2C (MTCY10H4.18c)%2C len: 514 aa. PstP%2Cphosphoserine/threonine phosphatase. Experimental studies have shown that PstP specifically dephosporylates model phospho-Ser/Thr substrates and it is likely that PknB (Rv0014c) and PstP may act as a functional pair in vivo to control mycobacterial cell growth (See Boitel et al.%2C2003).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pstP;locus_tag=Rv0018c;product=Phosphoserine/threonine phosphatase PstP;protein_id=CCP42740.1;transl_table=11
AL123456.3	EMBL	repeat_region	23173	23273	.	-	.	ID=id-AL123456.3:23173..23273;Note=101 bp Mycobacterial Interspersed Repetitive Unit%2CClass I. See Supply et al. (1997) Molecular Microbiology 26%2C 991-1003;gbkey=repeat_region
AL123456.3	EMBL	gene	23270	23737	.	-	.	ID=gene-Rv0019c;Name=fhaB;gbkey=Gene;gene=fhaB;gene_biotype=protein_coding;locus_tag=Rv0019c
AL123456.3	EMBL	CDS	23270	23737	.	-	0	ID=cds-CCP42741.1;Parent=gene-Rv0019c;Dbxref=EnsemblGenomes-Gn:Rv0019c,EnsemblGenomes-Tr:CCP42741,GOA:P9WJB5,InterPro:IPR000253,InterPro:IPR008984,NCBI_GP:CCP42741.1;Name=CCP42741.1;Note=Rv0019c%2C (MTCY10H4.19c)%2C len: 155 aa. FhaB%2Cconserved protein with forkhead-associated domain (IPR000253)%2C probably involved in signal transduction.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fhaB;locus_tag=Rv0019c;product=Conserved protein with FHA domain%2C FhaB;protein_id=CCP42741.1;transl_table=11
AL123456.3	EMBL	gene	23861	25444	.	-	.	ID=gene-Rv0020c;Name=fhaA;gbkey=Gene;gene=fhaA;gene_biotype=protein_coding;gene_synonym=TB39.8;locus_tag=Rv0020c
AL123456.3	EMBL	CDS	23861	25444	.	-	0	ID=cds-CCP42742.1;Parent=gene-Rv0020c;Dbxref=EnsemblGenomes-Gn:Rv0020c,EnsemblGenomes-Tr:CCP42742,GOA:P71590,InterPro:IPR000253,InterPro:IPR008984,InterPro:IPR022128,PDB:2LC0,PDB:2LC1,PDB:3OUN,PDB:3PO8,PDB:3POA,NCBI_GP:CCP42742.1;Name=CCP42742.1;Note=Rv0020c%2C (MTCY10H4.20c)%2C len: 527 aa. FhaA%2C TB39.8%2Cconserved protein with forkhead-associated domain (IPR000253) at C-terminus%2C may be involved in signal transduction. Alternative start codon in position 24979 has been suggested (see citation below). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fhaA;locus_tag=Rv0020c;product=Conserved protein with FHA domain%2C FhaA;protein_id=CCP42742.1;transl_table=11
AL123456.3	EMBL	gene	25644	25726	.	+	.	ID=gene-leuT;Name=leuT;gbkey=Gene;gene=leuT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	25644	25726	.	+	.	ID=rna-leuT;Parent=gene-leuT;Note=codon recognized: CUG%3B leuT%2C tRNA-Leu%2C anticodon cag%2C length %3D 83;anticodon=(pos:25677..25679);gbkey=tRNA;gene=leuT;product=tRNA-Leu
AL123456.3	EMBL	exon	25644	25726	.	+	.	ID=exon-leuT-1;Parent=rna-leuT;Note=codon recognized: CUG%3B leuT%2C tRNA-Leu%2C anticodon cag%2C length %3D 83;anticodon=(pos:25677..25679);gbkey=tRNA;gene=leuT;product=tRNA-Leu
AL123456.3	EMBL	gene	25913	26881	.	-	.	ID=gene-Rv0021c;Name=Rv0021c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0021c
AL123456.3	EMBL	CDS	25913	26881	.	-	0	ID=cds-CCP42743.1;Parent=gene-Rv0021c;Dbxref=EnsemblGenomes-Gn:Rv0021c,EnsemblGenomes-Tr:CCP42743,GOA:P71591,InterPro:IPR004136,InterPro:IPR013785,UniProtKB/TrEMBL:P71591,NCBI_GP:CCP42743.1;Name=CCP42743.1;Note=Rv0021c%2C (MTCY10H4.21c)%2C len: 322 aa. Conserved hypothetical protein%2C similar to various proteins.;gbkey=CDS;locus_tag=Rv0021c;product=Conserved hypothetical protein;protein_id=CCP42743.1;transl_table=11
AL123456.3	EMBL	gene	27023	27442	.	-	.	ID=gene-Rv0022c;Name=whiB5;gbkey=Gene;gene=whiB5;gene_biotype=protein_coding;gene_synonym=whmG;locus_tag=Rv0022c
AL123456.3	EMBL	CDS	27023	27442	.	-	0	ID=cds-CCP42744.1;Parent=gene-Rv0022c;Dbxref=EnsemblGenomes-Gn:Rv0022c,EnsemblGenomes-Tr:CCP42744,GOA:P71592,InterPro:IPR003482,NCBI_GP:CCP42744.1;Name=CCP42744.1;Note=Rv0022c%2C (MTCY10H4.22c)%2C len: 139 aa. Probable whiB5 (alternate gene name: whmG)%2C WhiB-like regulatory protein (see citations below)%2C similar to WhiB paralogue of Streptomyces coelicolor%2C wblE gene product (85 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=whiB5;locus_tag=Rv0022c;product=Probable transcriptional regulatory protein WhiB-like WhiB5;protein_id=CCP42744.1;transl_table=11
AL123456.3	EMBL	gene	27595	28365	.	+	.	ID=gene-Rv0023;Name=Rv0023;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0023
AL123456.3	EMBL	CDS	27595	28365	.	+	0	ID=cds-CCP42745.1;Parent=gene-Rv0023;Dbxref=EnsemblGenomes-Gn:Rv0023,EnsemblGenomes-Tr:CCP42745,GOA:P9WMI3,InterPro:IPR001387,InterPro:IPR010982,NCBI_GP:CCP42745.1;Name=CCP42745.1;Note=Rv0023%2C (MTCY10H4.23)%2C len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615%2C +4.69 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0023;product=Possible transcriptional regulatory protein;protein_id=CCP42745.1;transl_table=11
AL123456.3	EMBL	gene	28362	29207	.	+	.	ID=gene-Rv0024;Name=Rv0024;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0024
AL123456.3	EMBL	CDS	28362	29207	.	+	0	ID=cds-CCP42746.1;Parent=gene-Rv0024;Dbxref=EnsemblGenomes-Gn:Rv0024,EnsemblGenomes-Tr:CCP42746,GOA:P71594,InterPro:IPR000064,UniProtKB/TrEMBL:P71594,NCBI_GP:CCP42746.1;Name=CCP42746.1;Note=Rv0024%2C (MTCY10H4.24)%2C len: 281 aa. Putative secreted protein%2C p60 homologue%2C similar to many. Similar to Mycobacterium tuberculosis proteins Rv1477%2C Rv1478%2CRv1566c%2C Rv2190c. Could belong to the E. coli NLPC / listeria P60 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0024;product=Putative secreted protein P60-related protein;protein_id=CCP42746.1;transl_table=11
AL123456.3	EMBL	gene	29245	29607	.	+	.	ID=gene-Rv0025;Name=Rv0025;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0025
AL123456.3	EMBL	CDS	29245	29607	.	+	0	ID=cds-CCP42747.1;Parent=gene-Rv0025;Dbxref=EnsemblGenomes-Gn:Rv0025,EnsemblGenomes-Tr:CCP42747,InterPro:IPR019710,NCBI_GP:CCP42747.1;Name=CCP42747.1;Note=Rv0025%2C (MTCY10H4.25)%2C len: 120 aa. Conserved hypothetical protein%2C showing some similarity to other proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 aa)%2C FASTA score: (37.6%25 identity in 101 aa overlap)%2C and Rv0026 FASTA score: (35.4%25 identity in 113 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0025;product=Conserved hypothetical protein;protein_id=CCP42747.1;transl_table=11
AL123456.3	EMBL	gene	29722	31068	.	+	.	ID=gene-Rv0026;Name=Rv0026;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0026
AL123456.3	EMBL	CDS	29722	31068	.	+	0	ID=cds-CCP42748.1;Parent=gene-Rv0026;Dbxref=EnsemblGenomes-Gn:Rv0026,EnsemblGenomes-Tr:CCP42748,InterPro:IPR019710,NCBI_GP:CCP42748.1;Name=CCP42748.1;Note=Rv0026%2C (MTCY10H4.26)%2C len: 448 aa. Conserved hypothetical protein%2C showing some similarity to other proteins from Mycobacterium tuberculosis: Rv0025 FASTA score: (35.4%25 identity in 113 aa overlap) and Rv0739 (268 aa)%2C FASTA score: (32.4%25 identity in 142 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0026;product=Conserved hypothetical protein;protein_id=CCP42748.1;transl_table=11
AL123456.3	EMBL	gene	31189	31506	.	+	.	ID=gene-Rv0027;Name=Rv0027;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0027
AL123456.3	EMBL	CDS	31189	31506	.	+	0	ID=cds-CCP42749.1;Parent=gene-Rv0027;Dbxref=EnsemblGenomes-Gn:Rv0027,EnsemblGenomes-Tr:CCP42749,InterPro:IPR022536,NCBI_GP:CCP42749.1;Name=CCP42749.1;Note=Rv0027%2C (MTCY10H4.27)%2C len: 105 aa. Conserved hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0027;product=Conserved hypothetical protein;protein_id=CCP42749.1;transl_table=11
AL123456.3	EMBL	gene	31514	31819	.	+	.	ID=gene-Rv0028;Name=Rv0028;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0028
AL123456.3	EMBL	CDS	31514	31819	.	+	0	ID=cds-CCP42750.1;Parent=gene-Rv0028;Dbxref=EnsemblGenomes-Gn:Rv0028,EnsemblGenomes-Tr:CCP42750,InterPro:IPR024426,NCBI_GP:CCP42750.1;Name=CCP42750.1;Note=Rv0028%2C (MTCY10H4.28)%2C len: 101 aa. Conserved hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0028;product=Conserved hypothetical protein;protein_id=CCP42750.1;transl_table=11
AL123456.3	EMBL	gene	32057	33154	.	+	.	ID=gene-Rv0029;Name=Rv0029;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0029
AL123456.3	EMBL	CDS	32057	33154	.	+	0	ID=cds-CCP42751.1;Parent=gene-Rv0029;Dbxref=EnsemblGenomes-Gn:Rv0029,EnsemblGenomes-Tr:CCP42751,GOA:P71599,UniProtKB/TrEMBL:P71599,NCBI_GP:CCP42751.1;Name=CCP42751.1;Note=Rv0029%2C (MTCY10H4.29)%2C len: 365 aa. Conserved hypothetical protein%2C showing some similarity to other proteins from Mycobacterium tuberculosis e.g. C-terminal region of Rv2082%3B Rv3899c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0029;product=Conserved hypothetical protein;protein_id=CCP42751.1;transl_table=11
AL123456.3	EMBL	gene	33224	33553	.	+	.	ID=gene-Rv0030;Name=Rv0030;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0030
AL123456.3	EMBL	CDS	33224	33553	.	+	0	ID=cds-CCP42752.1;Parent=gene-Rv0030;Dbxref=EnsemblGenomes-Gn:Rv0030,EnsemblGenomes-Tr:CCP42752,InterPro:IPR024296,NCBI_GP:CCP42752.1;Name=CCP42752.1;Note=Rv0030%2C (MTCY10H4.30)%2C len: 109 aa. Conserved hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0030;product=Conserved hypothetical protein;protein_id=CCP42752.1;transl_table=11
AL123456.3	EMBL	gene	33582	33794	.	+	.	ID=gene-Rv0031;Name=Rv0031;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0031
AL123456.3	EMBL	CDS	33582	33794	.	+	0	ID=cds-CCP42753.1;Parent=gene-Rv0031;Dbxref=EnsemblGenomes-Gn:Rv0031,EnsemblGenomes-Tr:CCP42753,UniProtKB/TrEMBL:P71601,NCBI_GP:CCP42753.1;Name=CCP42753.1;Note=Rv0031%2C (MTCY10H4.31)%2C len: 70 aa. Possible remnant of a transposase%2C showing partial similarity to mycobacterial transposases in a short overlap%2C e.g. Rv2791c|MTV002_57 (459 aa)%2C FASTA score: (72.2%25 identity in 36 aa overlap)%3B Rv2885c%2C Rv2978c%2C Rv3827c%2C etc.;gbkey=CDS;locus_tag=Rv0031;product=Possible remnant of a transposase;protein_id=CCP42753.1;transl_table=11
AL123456.3	EMBL	gene	34295	36610	.	+	.	ID=gene-Rv0032;Name=bioF2;gbkey=Gene;gene=bioF2;gene_biotype=protein_coding;locus_tag=Rv0032
AL123456.3	EMBL	CDS	34295	36610	.	+	0	ID=cds-CCP42754.1;Parent=gene-Rv0032;Dbxref=EnsemblGenomes-Gn:Rv0032,EnsemblGenomes-Tr:CCP42754,GOA:P9WQ85,InterPro:IPR001917,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR016181,NCBI_GP:CCP42754.1;Name=CCP42754.1;Note=Rv0032%2C (MTCY10H4.32)%2C len: 771 aa. Probable bioF2%2C8-amino-7-oxononanoate synthase%2C with its C-terminal similar to others. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. Belongs to class-II of pyridoxal-phosphate-dependent aminotransferases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bioF2;inference=protein motif:PROSITE:PS00599;locus_tag=Rv0032;product=Possible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase);protein_id=CCP42754.1;transl_table=11
AL123456.3	EMBL	gene	36607	36870	.	+	.	ID=gene-Rv0033;Name=acpA;gbkey=Gene;gene=acpA;gene_biotype=protein_coding;gene_synonym=acpP;locus_tag=Rv0033
AL123456.3	EMBL	CDS	36607	36870	.	+	0	ID=cds-CCP42755.1;Parent=gene-Rv0033;Dbxref=EnsemblGenomes-Gn:Rv0033,EnsemblGenomes-Tr:CCP42755,GOA:I6WX95,InterPro:IPR003231,InterPro:IPR009081,UniProtKB/TrEMBL:I6WX95,NCBI_GP:CCP42755.1;Name=CCP42755.1;Note=Rv0033%2C (MTCY10H4.33)%2C len: 87 aa. Probable acpA (alternate gene name: acpP)%2C acyl carrier protein%2C similar to others. Also similar to proteins of Mycobacterium tuberculosis Rv1344 and Rv2244 (31.5%25 identity in 73 aa overlap).;gbkey=CDS;gene=acpA;locus_tag=Rv0033;product=Probable acyl carrier protein AcpA (ACP);protein_id=CCP42755.1;transl_table=11
AL123456.3	EMBL	gene	36867	37262	.	+	.	ID=gene-Rv0034;Name=Rv0034;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0034
AL123456.3	EMBL	CDS	36867	37262	.	+	0	ID=cds-CCP42756.1;Parent=gene-Rv0034;Dbxref=EnsemblGenomes-Gn:Rv0034,EnsemblGenomes-Tr:CCP42756,InterPro:IPR009959,NCBI_GP:CCP42756.1;Name=CCP42756.1;Note=Rv0034%2C (MTCY10H4.34)%2C len: 131 aa. Conserved hypothetical protein%2C showing weak similarity to AE001980|AE001980_7 hypothetical protein from Deinococcus radiodurans (120 aa)%2C FASTA scores: opt: 141%2C E(): 0.0028%2C(29.3%25 identity in 123 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0034;product=Conserved hypothetical protein;protein_id=CCP42756.1;transl_table=11
AL123456.3	EMBL	gene	37259	38947	.	+	.	ID=gene-Rv0035;Name=fadD34;gbkey=Gene;gene=fadD34;gene_biotype=protein_coding;locus_tag=Rv0035
AL123456.3	EMBL	CDS	37259	38947	.	+	0	ID=cds-CCP42757.1;Parent=gene-Rv0035;Dbxref=EnsemblGenomes-Gn:Rv0035,EnsemblGenomes-Tr:CCP42757,GOA:L7N699,InterPro:IPR000873,UniProtKB/TrEMBL:L7N699,NCBI_GP:CCP42757.1;Name=CCP42757.1;Note=Rv0035%2C (MTCY10H4.35)%2C len: 562 aa. Probable fadD34%2Cfatty-acid-CoA synthetase%2C similar to many.;gbkey=CDS;gene=fadD34;locus_tag=Rv0035;product=Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP42757.1;transl_table=11
AL123456.3	EMBL	gene	39056	39829	.	-	.	ID=gene-Rv0036c;Name=Rv0036c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0036c
AL123456.3	EMBL	CDS	39056	39829	.	-	0	ID=cds-CCP42758.1;Parent=gene-Rv0036c;Dbxref=EnsemblGenomes-Gn:Rv0036c,EnsemblGenomes-Tr:CCP42758,GOA:P9WM91,InterPro:IPR013917,InterPro:IPR017517,InterPro:IPR017518,InterPro:IPR024344,InterPro:IPR027369,NCBI_GP:CCP42758.1;Name=CCP42758.1;Note=Rv0036c%2C (MTCY10H4.36c)%2C len: 257 aa. Conserved protein%2C highly similar to CAB95889.1|AL359988 conserved hypothetical protein from Streptomyces (276 aa). Also some similarity to Rv3099c|MTCY164_10 (283 aa)%2C FASTA scores: E(): 3.3e-05%2C (25.9%25 identity in 205 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0036c;product=Conserved protein;protein_id=CCP42758.1;transl_table=11
AL123456.3	EMBL	gene	39877	41202	.	-	.	ID=gene-Rv0037c;Name=Rv0037c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0037c
AL123456.3	EMBL	CDS	39877	41202	.	-	0	ID=cds-CCP42759.1;Parent=gene-Rv0037c;Dbxref=EnsemblGenomes-Gn:Rv0037c,EnsemblGenomes-Tr:CCP42759,GOA:P9WJY1,InterPro:IPR011701,InterPro:IPR016196,NCBI_GP:CCP42759.1;Name=CCP42759.1;Note=Rv0037c%2C (MTCY10H4.37c)%2C len: 441 aa. Probable conserved integral membrane protein%2C member of major facilitator superfamily (MFS) possibly involved in transport of macrolide.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0037c;product=Probable conserved integral membrane protein;protein_id=CCP42759.1;transl_table=11
AL123456.3	EMBL	gene	41304	41912	.	+	.	ID=gene-Rv0038;Name=Rv0038;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0038
AL123456.3	EMBL	CDS	41304	41912	.	+	0	ID=cds-CCP42760.1;Parent=gene-Rv0038;Dbxref=EnsemblGenomes-Gn:Rv0038,EnsemblGenomes-Tr:CCP42760,GOA:P9WFK5,InterPro:IPR003774,NCBI_GP:CCP42760.1;Name=CCP42760.1;Note=Rv0038%2C (MTCY10H4.38)%2C len: 202 aa. Conserved protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0038;product=Conserved protein;protein_id=CCP42760.1;transl_table=11
AL123456.3	EMBL	gene	42004	42351	.	-	.	ID=gene-Rv0039c;Name=Rv0039c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0039c
AL123456.3	EMBL	CDS	42004	42351	.	-	0	ID=cds-CCP42761.1;Parent=gene-Rv0039c;Dbxref=EnsemblGenomes-Gn:Rv0039c,EnsemblGenomes-Tr:CCP42761,GOA:P9WM89,NCBI_GP:CCP42761.1;Name=CCP42761.1;Note=Rv0039c%2C (MTCY21D4.02c%2C MTCY10H4.39c)%2C len: 115 aa. Possible conserved transmembrane protein. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0039c;product=Possible conserved transmembrane protein;protein_id=CCP42761.1;transl_table=11
AL123456.3	EMBL	gene	42433	43365	.	-	.	ID=gene-Rv0040c;Name=mtc28;gbkey=Gene;gene=mtc28;gene_biotype=protein_coding;locus_tag=Rv0040c
AL123456.3	EMBL	CDS	42433	43365	.	-	0	ID=cds-CCP42762.1;Parent=gene-Rv0040c;Dbxref=EnsemblGenomes-Gn:Rv0040c,EnsemblGenomes-Tr:CCP42762,GOA:P9WIM9,InterPro:IPR019674,NCBI_GP:CCP42762.1;Name=CCP42762.1;Note=Rv0040c%2C (MTCY21D4.03c)%2C len: 310 aa. Mtc28%2Csecreted proline rich 28 kDa antigen protein (has hydrophobic stretch at N-terminus) (see citation below). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mtc28;locus_tag=Rv0040c;product=Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen);protein_id=CCP42762.1;transl_table=11
AL123456.3	EMBL	gene	43562	46471	.	+	.	ID=gene-Rv0041;Name=leuS;gbkey=Gene;gene=leuS;gene_biotype=protein_coding;locus_tag=Rv0041
AL123456.3	EMBL	CDS	43562	46471	.	+	0	ID=cds-CCP42763.1;Parent=gene-Rv0041;Dbxref=EnsemblGenomes-Gn:Rv0041,EnsemblGenomes-Tr:CCP42763,GOA:P9WFV1,InterPro:IPR001412,InterPro:IPR002302,InterPro:IPR009008,InterPro:IPR009080,InterPro:IPR013155,InterPro:IPR014729,InterPro:IPR015413,InterPro:IPR025709,NCBI_GP:CCP42763.1;Name=CCP42763.1;Note=Rv0041%2C (MTCY21D4.04)%2C len: 969 aa. Probable leucyl-tRNA synthetase%2C similar to many. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=leuS;inference=protein motif:PROSITE:PS00178;locus_tag=Rv0041;product=Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS);protein_id=CCP42763.1;transl_table=11
AL123456.3	EMBL	gene	46581	47207	.	-	.	ID=gene-Rv0042c;Name=Rv0042c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0042c
AL123456.3	EMBL	CDS	46581	47207	.	-	0	ID=cds-CCP42764.1;Parent=gene-Rv0042c;Dbxref=EnsemblGenomes-Gn:Rv0042c,EnsemblGenomes-Tr:CCP42764,GOA:P71699,InterPro:IPR000835,InterPro:IPR011991,UniProtKB/TrEMBL:P71699,NCBI_GP:CCP42764.1;Name=CCP42764.1;Note=Rv0042c%2C (MTCY21D4.05c)%2C len: 208 aa. Possible transcriptional regulatory protein%2C MarR-family. Some similarity to Mycobacterium tuberculosis proteins Rv2327%2CRv0880%2C and Rv1404.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0042c;product=Possible transcriptional regulatory protein (probably MarR-family);protein_id=CCP42764.1;transl_table=11
AL123456.3	EMBL	gene	47366	48100	.	-	.	ID=gene-Rv0043c;Name=Rv0043c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0043c
AL123456.3	EMBL	CDS	47366	48100	.	-	0	ID=cds-CCP42765.1;Parent=gene-Rv0043c;Dbxref=EnsemblGenomes-Gn:Rv0043c,EnsemblGenomes-Tr:CCP42765,GOA:P9WMG9,InterPro:IPR000524,InterPro:IPR011991,NCBI_GP:CCP42765.1;Name=CCP42765.1;Note=Rv0043c%2C (MTCY21D4.06c)%2C len: 244 aa. Probable transcriptional regulator%2C GntR family%2C similar to others.;gbkey=CDS;locus_tag=Rv0043c;product=Probable transcriptional regulatory protein (probably GntR-family);protein_id=CCP42765.1;transl_table=11
AL123456.3	EMBL	gene	48233	49027	.	-	.	ID=gene-Rv0044c;Name=Rv0044c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0044c
AL123456.3	EMBL	CDS	48233	49027	.	-	0	ID=cds-CCP42766.1;Parent=gene-Rv0044c;Dbxref=EnsemblGenomes-Gn:Rv0044c,EnsemblGenomes-Tr:CCP42766,GOA:P71701,InterPro:IPR011251,InterPro:IPR022480,UniProtKB/TrEMBL:P71701,NCBI_GP:CCP42766.1;Name=CCP42766.1;Note=Rv0044c%2C (MTCY21D4.07c)%2C len: 264 aa. Possible oxidoreductase%2C highly similar to AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase from Streptomyces lavendulae (264 aa). Also similar to Mycobacterium tuberculosis proteins e.g. Rv1855c%2C Rv0953c%2C Rv0791c%2C Rv0132c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0044c;product=Possible oxidoreductase;protein_id=CCP42766.1;transl_table=11
AL123456.3	EMBL	gene	49043	49939	.	-	.	ID=gene-Rv0045c;Name=Rv0045c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0045c
AL123456.3	EMBL	CDS	49043	49939	.	-	0	ID=cds-CCP42767.1;Parent=gene-Rv0045c;Dbxref=EnsemblGenomes-Gn:Rv0045c,EnsemblGenomes-Tr:CCP42767,GOA:I6XU97,InterPro:IPR000073,InterPro:IPR029058,UniProtKB/TrEMBL:I6XU97,NCBI_GP:CCP42767.1;Name=CCP42767.1;Note=Rv0045c%2C (MTCY21D4.08c)%2C len: 298 aa. Possible hydrolase%2C showing similarity with others. Also similar to Mycobacterium tuberculosis proteins Rv3473c%2C Rv1123c%2CRv1938%2C Rv3617%2C Rv3670%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0045c;product=Possible hydrolase;protein_id=CCP42767.1;transl_table=11
AL123456.3	EMBL	gene	50021	51124	.	-	.	ID=gene-Rv0046c;Name=ino1;gbkey=Gene;gene=ino1;gene_biotype=protein_coding;gene_synonym=tbINO;locus_tag=Rv0046c
AL123456.3	EMBL	CDS	50021	51124	.	-	0	ID=cds-CCP42768.1;Parent=gene-Rv0046c;Dbxref=EnsemblGenomes-Gn:Rv0046c,EnsemblGenomes-Tr:CCP42768,GOA:P9WKI1,InterPro:IPR002587,InterPro:IPR013021,InterPro:IPR016040,InterPro:IPR017815,PDB:1GR0,NCBI_GP:CCP42768.1;Name=CCP42768.1;Note=Rv0046c%2C (MTCY21D4.09c)%2C len: 367 aa. Ino1 (alternate gene name: tbINO)%2C myo-inositol-1-phosphate synthase (see citations below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ino1;locus_tag=Rv0046c;product=myo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase);protein_id=CCP42768.1;transl_table=11
AL123456.3	EMBL	gene	51185	51727	.	-	.	ID=gene-Rv0047c;Name=Rv0047c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0047c
AL123456.3	EMBL	CDS	51185	51727	.	-	0	ID=cds-CCP42769.1;Parent=gene-Rv0047c;Dbxref=EnsemblGenomes-Gn:Rv0047c,EnsemblGenomes-Tr:CCP42769,InterPro:IPR005149,InterPro:IPR011991,UniProtKB/TrEMBL:P71704,NCBI_GP:CCP42769.1;Name=CCP42769.1;Note=Rv0047c%2C (MTCY21D4.10c)%2C len: 180 aa. Conserved protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0047c;product=Conserved protein;protein_id=CCP42769.1;transl_table=11
AL123456.3	EMBL	gene	51828	52697	.	-	.	ID=gene-Rv0048c;Name=Rv0048c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0048c
AL123456.3	EMBL	CDS	51828	52697	.	-	0	ID=cds-CCP42770.1;Parent=gene-Rv0048c;Dbxref=EnsemblGenomes-Gn:Rv0048c,EnsemblGenomes-Tr:CCP42770,GOA:P9WM87,InterPro:IPR012551,NCBI_GP:CCP42770.1;Name=CCP42770.1;Note=Rv0048c%2C MTCY21D4.11c%2C len: 289 aa. Possible membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0048c;product=Possible membrane protein;protein_id=CCP42770.1;transl_table=11
AL123456.3	EMBL	gene	52831	53244	.	+	.	ID=gene-Rv0049;Name=Rv0049;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0049
AL123456.3	EMBL	CDS	52831	53244	.	+	0	ID=cds-CCP42771.1;Parent=gene-Rv0049;Dbxref=EnsemblGenomes-Gn:Rv0049,EnsemblGenomes-Tr:CCP42771,NCBI_GP:CCP42771.1;Name=CCP42771.1;Note=Rv0049%2C (MTCY21D4.12)%2C len: 137 aa. Conserved hypothetical protein. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv0049;product=Conserved hypothetical protein;protein_id=CCP42771.1;transl_table=11
AL123456.3	EMBL	gene	53663	55699	.	+	.	ID=gene-Rv0050;Name=ponA1;gbkey=Gene;gene=ponA1;gene_biotype=protein_coding;locus_tag=Rv0050
AL123456.3	EMBL	CDS	53663	55699	.	+	0	ID=cds-CCP42772.1;Parent=gene-Rv0050;Dbxref=EnsemblGenomes-Gn:Rv0050,EnsemblGenomes-Tr:CCP42772,GOA:P71707,InterPro:IPR001264,InterPro:IPR001460,InterPro:IPR012338,InterPro:IPR023346,NCBI_GP:CCP42772.1;Name=CCP42772.1;Note=Rv0050%2C (MTCY21D4.13)%2C len: 678 aa. Probable ponA1%2Cpenicillin-binding protein (class A)%2C bienzymatic protein with transglycosylase and transpeptidase activities (see Graham %26 Clark-Curtiss 1999)%2C highly similar to many (see Billman-Jacobe et al.%2C 1999). Belongs to the transglycosylase family in the N-terminal section%2C and to the transpeptidase family in the C-terminal section.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ponA1;locus_tag=Rv0050;product=Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase);protein_id=CCP42772.1;transl_table=11
AL123456.3	EMBL	gene	55696	57378	.	+	.	ID=gene-Rv0051;Name=Rv0051;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0051
AL123456.3	EMBL	CDS	55696	57378	.	+	0	ID=cds-CCP42773.1;Parent=gene-Rv0051;Dbxref=EnsemblGenomes-Gn:Rv0051,EnsemblGenomes-Tr:CCP42773,GOA:P71708,InterPro:IPR016570,InterPro:IPR018584,UniProtKB/TrEMBL:P71708,NCBI_GP:CCP42773.1;Name=CCP42773.1;Note=Rv0051%2C (MTCY21D4.14)%2C len:560 aa. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Probable conserved transmembrane protein.;gbkey=CDS;locus_tag=Rv0051;product=Probable conserved transmembrane protein;protein_id=CCP42773.1;transl_table=11
AL123456.3	EMBL	gene	57410	57973	.	+	.	ID=gene-Rv0052;Name=Rv0052;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0052
AL123456.3	EMBL	CDS	57410	57973	.	+	0	ID=cds-CCP42774.1;Parent=gene-Rv0052;Dbxref=EnsemblGenomes-Gn:Rv0052,EnsemblGenomes-Tr:CCP42774,InterPro:IPR025628,InterPro:IPR029062,UniProtKB/TrEMBL:I6Y6S3,NCBI_GP:CCP42774.1;Name=CCP42774.1;Note=Rv0052%2C (MTCY21D4.15)%2C len: 187 aa. Conserved protein%2C similar to others including Rv1930c from Mycobacterium tuberculosis (174 aa). May be a membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0052;product=Conserved protein;protein_id=CCP42774.1;transl_table=11
AL123456.3	EMBL	gene	58192	58482	.	+	.	ID=gene-Rv0053;Name=rpsF;gbkey=Gene;gene=rpsF;gene_biotype=protein_coding;locus_tag=Rv0053
AL123456.3	EMBL	CDS	58192	58482	.	+	0	ID=cds-CCP42775.1;Parent=gene-Rv0053;Dbxref=EnsemblGenomes-Gn:Rv0053,EnsemblGenomes-Tr:CCP42775,GOA:P9WH31,InterPro:IPR000529,InterPro:IPR014717,InterPro:IPR020814,InterPro:IPR020815,NCBI_GP:CCP42775.1;Name=CCP42775.1;Note=Rv0053%2C (MTCY21D4.16)%2C len: 96 aa. rpsF%2C 30S ribosomal protein S6%2C highly similar to many. Contains PS01048 Ribosomal protein S6 signature. Belongs to the S6P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsF;inference=protein motif:PROSITE:PS01048;locus_tag=Rv0053;product=30S ribosomal protein S6 RpsF;protein_id=CCP42775.1;transl_table=11
AL123456.3	EMBL	gene	58586	59080	.	+	.	ID=gene-Rv0054;Name=ssb;gbkey=Gene;gene=ssb;gene_biotype=protein_coding;locus_tag=Rv0054
AL123456.3	EMBL	CDS	58586	59080	.	+	0	ID=cds-CCP42776.1;Parent=gene-Rv0054;Dbxref=EnsemblGenomes-Gn:Rv0054,EnsemblGenomes-Tr:CCP42776,GOA:P9WGD5,InterPro:IPR000424,InterPro:IPR011344,InterPro:IPR012340,PDB:1UE1,PDB:1UE5,PDB:1UE6,PDB:1UE7,NCBI_GP:CCP42776.1;Name=CCP42776.1;Note=Rv0054%2C (MTCY21D4.17)%2C len: 164 aa. ssb%2Csingle-strand binding protein (see Mizrahi %26 Andersen 1998)%2C highly similar to others. Belongs to the SSB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ssb;locus_tag=Rv0054;product=Single-strand binding protein Ssb (helix-destabilizing protein);protein_id=CCP42776.1;transl_table=11
AL123456.3	EMBL	gene	59122	59376	.	+	.	ID=gene-Rv0055;Name=rpsR1;gbkey=Gene;gene=rpsR1;gene_biotype=protein_coding;gene_synonym=rpsR;locus_tag=Rv0055
AL123456.3	EMBL	CDS	59122	59376	.	+	0	ID=cds-CCP42777.1;Parent=gene-Rv0055;Dbxref=EnsemblGenomes-Gn:Rv0055,EnsemblGenomes-Tr:CCP42777,GOA:P9WH49,InterPro:IPR001648,InterPro:IPR018275,NCBI_GP:CCP42777.1;Name=CCP42777.1;Note=Rv0055%2C (MTCY21D4.18)%2C len: 84 aa. rpsR1%2C 30S ribosomal protein S18-1. Belongs to the S18P family of ribosomal proteins. Note that previously known as rpsR.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsR1;locus_tag=Rv0055;product=30S ribosomal protein S18-1 RpsR1;protein_id=CCP42777.1;transl_table=11
AL123456.3	EMBL	gene	59409	59867	.	+	.	ID=gene-Rv0056;Name=rplI;gbkey=Gene;gene=rplI;gene_biotype=protein_coding;locus_tag=Rv0056
AL123456.3	EMBL	CDS	59409	59867	.	+	0	ID=cds-CCP42778.1;Parent=gene-Rv0056;Dbxref=EnsemblGenomes-Gn:Rv0056,EnsemblGenomes-Tr:CCP42778,GOA:P9WH79,InterPro:IPR000244,InterPro:IPR000644,InterPro:IPR009027,InterPro:IPR020069,InterPro:IPR020070,InterPro:IPR020594,NCBI_GP:CCP42778.1;Name=CCP42778.1;Note=Rv0056%2C (MTCY21D4.19)%2C len: 152 aa. rplI%2C 50S ribosomal protein L9. Contains PS00651 Ribosomal protein L9 signature. Belongs to the L9P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplI;inference=protein motif:PROSITE:PS00651;locus_tag=Rv0056;product=50S ribosomal protein L9 RplI;protein_id=CCP42778.1;transl_table=11
AL123456.3	EMBL	gene	59896	60417	.	+	.	ID=gene-Rv0057;Name=Rv0057;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0057
AL123456.3	EMBL	CDS	59896	60417	.	+	0	ID=cds-CCP42779.1;Parent=gene-Rv0057;Dbxref=EnsemblGenomes-Gn:Rv0057,EnsemblGenomes-Tr:CCP42779,NCBI_GP:CCP42779.1;Name=CCP42779.1;Note=Rv0057%2C (MTCY21D4.20)%2C len: 173 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0057;product=Hypothetical protein;protein_id=CCP42779.1;transl_table=11
AL123456.3	EMBL	gene	60396	63020	.	+	.	ID=gene-Rv0058;Name=dnaB;gbkey=Gene;gene=dnaB;gene_biotype=protein_coding;locus_tag=Rv0058
AL123456.3	EMBL	CDS	60396	63020	.	+	0	ID=cds-CCP42780.1;Parent=gene-Rv0058;Dbxref=EnsemblGenomes-Gn:Rv0058,EnsemblGenomes-Tr:CCP42780,GOA:P9WMR3,InterPro:IPR003586,InterPro:IPR003587,InterPro:IPR003593,InterPro:IPR004042,InterPro:IPR006141,InterPro:IPR006142,InterPro:IPR007692,InterPro:IPR007693,InterPro:IPR007694,InterPro:IPR016136,InterPro:IPR027417,InterPro:IPR027434,InterPro:IPR028992,PDB:2R5U,NCBI_GP:CCP42780.1;Name=CCP42780.1;Note=Rv0058%2C (MTV030.01%2C MTCY21D4.21)%2C len: 874 aa. Probable dnaB%2C replicative DNA helicase. Contains an intein (position 61630..62838) similar to%2C and in the same position as%2C those in Sycnechocystis and Rhodothermus marinus (see citation below) and C-terminal extein (position 62839..63015) similar to many dnaB proteins. This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. Belongs to the helicase family%2C DNAB subfamily. In the intein section%3B belongs to the homing endonuclease family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaB;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0058;product=Probable replicative DNA helicase DnaB;protein_id=CCP42780.1;transl_table=11
AL123456.3	EMBL	gene	63200	63892	.	+	.	ID=gene-Rv0059;Name=Rv0059;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0059
AL123456.3	EMBL	CDS	63200	63892	.	+	0	ID=cds-CCP42781.1;Parent=gene-Rv0059;Dbxref=EnsemblGenomes-Gn:Rv0059,EnsemblGenomes-Tr:CCP42781,InterPro:IPR029494,UniProtKB/TrEMBL:O53604,NCBI_GP:CCP42781.1;Name=CCP42781.1;Note=Rv0059%2C (MTV030.02)%2C len: 230 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0059;product=Hypothetical protein;protein_id=CCP42781.1;transl_table=11
AL123456.3	EMBL	gene	63909	64967	.	+	.	ID=gene-Rv0060;Name=Rv0060;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0060
AL123456.3	EMBL	CDS	63909	64967	.	+	0	ID=cds-CCP42782.1;Parent=gene-Rv0060;Dbxref=EnsemblGenomes-Gn:Rv0060,EnsemblGenomes-Tr:CCP42782,GOA:O53605,InterPro:IPR002589,UniProtKB/TrEMBL:O53605,NCBI_GP:CCP42782.1;Name=CCP42782.1;Note=Rv0060%2C (MTV030.03)%2C len: 352 aa. Conserved hypothetical protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0060;product=Conserved hypothetical protein;protein_id=CCP42782.1;transl_table=11
AL123456.3	EMBL	gene	65012	65350	.	-	.	ID=gene-Rv0061c;Name=Rv0061c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0061c
AL123456.3	EMBL	CDS	65012	65350	.	-	0	ID=cds-CCP42783.1;Parent=gene-Rv0061c;Dbxref=EnsemblGenomes-Gn:Rv0061c,EnsemblGenomes-Tr:CCP42783,UniProtKB/TrEMBL:I6X8E6,NCBI_GP:CCP42783.1;Name=CCP42783.1;Note=Rv0061c%2C len: 112 aa. Conserved hypothetical protein supported by RNA-seq data. Similar to MMAR_3839%2C 76%25 identity in 112 aa overlap. Replaces questionable ORF Rv0061 (MTV030.04).;gbkey=CDS;locus_tag=Rv0061c;product=Hypothetical protein;protein_id=CCP42783.1;transl_table=11
AL123456.3	EMBL	gene	65552	66694	.	+	.	ID=gene-Rv0062;Name=celA1;gbkey=Gene;gene=celA1;gene_biotype=protein_coding;gene_synonym=cel6,celA;locus_tag=Rv0062
AL123456.3	EMBL	CDS	65552	66694	.	+	0	ID=cds-CCP42784.1;Parent=gene-Rv0062;Dbxref=EnsemblGenomes-Gn:Rv0062,EnsemblGenomes-Tr:CCP42784,GOA:Q79G13,InterPro:IPR016288,PDB:1UOZ,PDB:1UP0,PDB:1UP2,PDB:1UP3,UniProtKB/TrEMBL:Q79G13,NCBI_GP:CCP42784.1;Name=CCP42784.1;Note=Rv0062%2C (MTV030.05)%2C len: 380 aa. Possible celA1%2Ccellulase%2C similar to many. Seems to belong to cellulase family B (family 6 of glycosyl hydrolases). Note that previously known as celA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=celA1;locus_tag=Rv0062;product=Possible cellulase CelA1 (endoglucanase) (endo-1%2C4-beta-glucanase) (FI-cmcase) (carboxymethyl cellulase);protein_id=CCP42784.1;transl_table=11
AL123456.3	EMBL	gene	66923	68362	.	+	.	ID=gene-Rv0063;Name=Rv0063;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0063
AL123456.3	EMBL	CDS	66923	68362	.	+	0	ID=cds-CCP42785.1;Parent=gene-Rv0063;Dbxref=EnsemblGenomes-Gn:Rv0063,EnsemblGenomes-Tr:CCP42785,GOA:O53608,InterPro:IPR006093,InterPro:IPR006094,InterPro:IPR006311,InterPro:IPR012951,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,UniProtKB/TrEMBL:O53608,NCBI_GP:CCP42785.1;Name=CCP42785.1;Note=Rv0063%2C (MTV030.06)%2C len: 479 aa. Possible oxidoreductase%2C similar to many. Similar to Mycobacterium tuberculosis proteins e.g. Rv3107c%2C Rv1257c%2C etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00862;locus_tag=Rv0063;product=Possible oxidoreductase;protein_id=CCP42785.1;transl_table=11
AL123456.3	EMBL	gene	68620	71559	.	+	.	ID=gene-Rv0064;Name=Rv0064;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0064
AL123456.3	EMBL	CDS	68620	71559	.	+	0	ID=cds-CCP42786.1;Parent=gene-Rv0064;Dbxref=EnsemblGenomes-Gn:Rv0064,EnsemblGenomes-Tr:CCP42786,GOA:P9WFL5,InterPro:IPR005372,NCBI_GP:CCP42786.1;Name=CCP42786.1;Note=Rv0064%2C (MTV030.07)%2C len: 979 aa. Probable conserved transmembrane protein%2C similar to many. Contains probable coiled-coil domain from aa 948 to 976.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0064;product=Probable conserved transmembrane protein;protein_id=CCP42786.1;transl_table=11
AL123456.3	EMBL	gene	71589	71828	.	+	.	ID=gene-Rv0064A;Name=vapB1;gbkey=Gene;gene=vapB1;gene_biotype=protein_coding;locus_tag=Rv0064A
AL123456.3	EMBL	CDS	71589	71828	.	+	0	ID=cds-CCP42787.1;Parent=gene-Rv0064A;Dbxref=EnsemblGenomes-Gn:Rv0064A,EnsemblGenomes-Tr:CCP42787,GOA:P0CW29,InterPro:IPR010985,NCBI_GP:CCP42787.1;Name=CCP42787.1;Note=Rv0064A%2C len: 79 aa. Possible vapB1%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv0065 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv0300 (73 aa)%2CRv1721c (75 aa);gbkey=CDS;gene=vapB1;locus_tag=Rv0064A;product=Possible antitoxin VapB1;protein_id=CCP42787.1;transl_table=11
AL123456.3	EMBL	gene	71821	72222	.	+	.	ID=gene-Rv0065;Name=vapC1;gbkey=Gene;gene=vapC1;gene_biotype=protein_coding;locus_tag=Rv0065
AL123456.3	EMBL	CDS	71821	72222	.	+	0	ID=cds-CCP42788.1;Parent=gene-Rv0065;Dbxref=EnsemblGenomes-Gn:Rv0065,EnsemblGenomes-Tr:CCP42788,GOA:P9WFC1,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP42788.1;Name=CCP42788.1;Note=Rv0065%2C (MTV030.08)%2C len: 133 aa. Possible vapC1%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0064A%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to several others in Mycobacterium tuberculosis: Rv0960 (127 aa)%2C Rv1720c (129 aa)%2C and Rv0549c (137 aa).;gbkey=CDS;gene=vapC1;locus_tag=Rv0065;product=Possible toxin VapC1;protein_id=CCP42788.1;transl_table=11
AL123456.3	EMBL	gene	72274	74511	.	-	.	ID=gene-Rv0066c;Name=icd2;gbkey=Gene;gene=icd2;gene_biotype=protein_coding;locus_tag=Rv0066c
AL123456.3	EMBL	CDS	72274	74511	.	-	0	ID=cds-CCP42789.1;Parent=gene-Rv0066c;Dbxref=EnsemblGenomes-Gn:Rv0066c,EnsemblGenomes-Tr:CCP42789,GOA:O53611,InterPro:IPR004436,InterPro:IPR024084,UniProtKB/TrEMBL:O53611,NCBI_GP:CCP42789.1;Name=CCP42789.1;Note=Rv0066c%2C (MTV030.09c)%2C len: 745 aa. Probable icd2%2Cisocitrate dehydrogenase NADP-dependent. Belongs to the monomeric-type family of IDH. Note that in H37Rv%2C Rv0066c is named icd2 and Rv3339c is icd1 while in CDC1551 and Erdman strains%2C Rv0066c is icd1 and Rv3339c is icd2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=icd2;locus_tag=Rv0066c;product=Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP);protein_id=CCP42789.1;transl_table=11
AL123456.3	EMBL	gene	74629	75198	.	-	.	ID=gene-Rv0067c;Name=Rv0067c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0067c
AL123456.3	EMBL	CDS	74629	75198	.	-	0	ID=cds-CCP42790.1;Parent=gene-Rv0067c;Dbxref=EnsemblGenomes-Gn:Rv0067c,EnsemblGenomes-Tr:CCP42790,GOA:O53612,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O53612,NCBI_GP:CCP42790.1;Name=CCP42790.1;Note=Rv0067c%2C (MTV030.10c)%2C len: 189 aa. Possible transcriptional regulator%2C highly similar to many. Contains probable helix-turn-helix motif from aa 34 to 55 (Score 1523%2C +4.37 SD).;gbkey=CDS;locus_tag=Rv0067c;product=Possible transcriptional regulatory protein (possibly TetR-family);protein_id=CCP42790.1;transl_table=11
AL123456.3	EMBL	gene	75301	76212	.	+	.	ID=gene-Rv0068;Name=Rv0068;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0068
AL123456.3	EMBL	CDS	75301	76212	.	+	0	ID=cds-CCP42791.1;Parent=gene-Rv0068;Dbxref=EnsemblGenomes-Gn:Rv0068,EnsemblGenomes-Tr:CCP42791,GOA:O53613,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O53613,NCBI_GP:CCP42791.1;Name=CCP42791.1;Note=Rv0068%2C (MTV030.11)%2C len: 303 aa. Probable oxidoreductase%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0068;product=Probable oxidoreductase;protein_id=CCP42791.1;transl_table=11
AL123456.3	EMBL	gene	76237	77622	.	-	.	ID=gene-Rv0069c;Name=sdaA;gbkey=Gene;gene=sdaA;gene_biotype=protein_coding;locus_tag=Rv0069c
AL123456.3	EMBL	CDS	76237	77622	.	-	0	ID=cds-CCP42792.1;Parent=gene-Rv0069c;Dbxref=EnsemblGenomes-Gn:Rv0069c,EnsemblGenomes-Tr:CCP42792,GOA:P9WGT5,InterPro:IPR004644,InterPro:IPR005130,InterPro:IPR005131,InterPro:IPR029009,NCBI_GP:CCP42792.1;Name=CCP42792.1;Note=Rv0069c%2C (MTV030.12c)%2C len: 461 aa. Probable sdaA%2CL-serine dehydratase. Belongs to the iron-sulfur dependent L-serine dehydratase family. Cofactor: iron-sulfur (4FE-4S) (probable).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sdaA;locus_tag=Rv0069c;product=Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD);protein_id=CCP42792.1;transl_table=11
AL123456.3	EMBL	gene	77619	78896	.	-	.	ID=gene-Rv0070c;Name=glyA2;gbkey=Gene;gene=glyA2;gene_biotype=protein_coding;locus_tag=Rv0070c
AL123456.3	EMBL	CDS	77619	78896	.	-	0	ID=cds-CCP42793.1;Parent=gene-Rv0070c;Dbxref=EnsemblGenomes-Gn:Rv0070c,EnsemblGenomes-Tr:CCP42793,GOA:P9WGI7,InterPro:IPR001085,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR019798,NCBI_GP:CCP42793.1;Name=CCP42793.1;Note=Rv0070c%2C (MTV030.13c)%2C len: 425 aa. glyA2%2C serine hydroxymethyltransferase. Contains PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. Belongs to the ShmT family. Cofactor: pyridoxal phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glyA2;inference=protein motif:PROSITE:PS00096;locus_tag=Rv0070c;product=Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2);protein_id=CCP42793.1;transl_table=11
AL123456.3	EMBL	gene	79486	80193	.	+	.	ID=gene-Rv0071;Name=Rv0071;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0071
AL123456.3	EMBL	CDS	79486	80193	.	+	0	ID=cds-CCP42794.1;Parent=gene-Rv0071;Dbxref=EnsemblGenomes-Gn:Rv0071,EnsemblGenomes-Tr:CCP42794,GOA:O53616,InterPro:IPR000477,UniProtKB/TrEMBL:O53616,NCBI_GP:CCP42794.1;Name=CCP42794.1;Note=Rv0071%2C (MTV030.14)%2C len: 235 aa. Possible maturase%2Csimilar to many proteins of the group II intron maturase family. Contains 5 VDP repeats at N-terminus%2C these are also found in two Streptococcus plasmid hypothetical proteins Q52246|X17092 and Q54942|X66468.;gbkey=CDS;locus_tag=Rv0071;product=Possible maturase;protein_id=CCP42794.1;transl_table=11
AL123456.3	EMBL	repeat_region	79507	79551	.	+	.	ID=id-Rv0071;Note=5 x 9 bp GTGGACCCG repeats;gbkey=repeat_region;locus_tag=Rv0071
AL123456.3	EMBL	repeat_region	80236	80550	.	+	.	ID=id-AL123456.3:80236..80550;Note=(MTV030.15)%2C len: 315 nt. Probable REP'-1 pseudogene fragment%2C similar to many Mycobacterium tuberculosis proteins inside REP13E12 elements e.g. Q50655|Z95390|MTCY13E12.20 (317 aa)%2C FASTA scores%3B opt: 324 E(): 6.8e-17%2C 43.4%25 identity in 99 aa overlap%2C but no possible startsite.;gbkey=repeat_region
AL123456.3	EMBL	gene	80624	81673	.	+	.	ID=gene-Rv0072;Name=Rv0072;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0072
AL123456.3	EMBL	CDS	80624	81673	.	+	0	ID=cds-CCP42795.1;Parent=gene-Rv0072;Dbxref=EnsemblGenomes-Gn:Rv0072,EnsemblGenomes-Tr:CCP42795,GOA:P9WG17,InterPro:IPR003838,InterPro:IPR025857,NCBI_GP:CCP42795.1;Name=CCP42795.1;Note=Rv0072%2C (MTV030.16)%2C len: 349 aa. Probable glutamine-transport transmembrane protein ABC-transporter (see citation below). Note that supposed act with near ORF Rv0073|MTV030.17 ATP-binding protein ABC-transporter.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0072;product=Probable glutamine-transport transmembrane protein ABC transporter;protein_id=CCP42795.1;transl_table=11
AL123456.3	EMBL	gene	81676	82668	.	+	.	ID=gene-Rv0073;Name=Rv0073;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0073
AL123456.3	EMBL	CDS	81676	82668	.	+	0	ID=cds-CCP42796.1;Parent=gene-Rv0073;Dbxref=EnsemblGenomes-Gn:Rv0073,EnsemblGenomes-Tr:CCP42796,GOA:P9WQK5,InterPro:IPR000595,InterPro:IPR002373,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR014710,InterPro:IPR017871,InterPro:IPR018488,InterPro:IPR018490,InterPro:IPR027417,NCBI_GP:CCP42796.1;Name=CCP42796.1;Note=Rv0073%2C (MTV030.17)%2C len: 330 aa. Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below)%2C similar to many ATP-binding proteins. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2CPS00211 ABC transporters family signature%2C and PS00889 Cyclic nucleotide-binding domain signature 2. Belongs to the ATP-binding transport protein family (ABC transporters). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00889;locus_tag=Rv0073;product=Probable glutamine-transport ATP-binding protein ABC transporter;protein_id=CCP42796.1;transl_table=11
AL123456.3	EMBL	gene	82748	83983	.	+	.	ID=gene-Rv0074;Name=Rv0074;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0074
AL123456.3	EMBL	CDS	82748	83983	.	+	0	ID=cds-CCP42797.1;Parent=gene-Rv0074;Dbxref=EnsemblGenomes-Gn:Rv0074,EnsemblGenomes-Tr:CCP42797,GOA:O53619,InterPro:IPR006680,InterPro:IPR011059,UniProtKB/TrEMBL:O53619,NCBI_GP:CCP42797.1;Name=CCP42797.1;Note=Rv0074%2C (MTV030.18)%2C len: 411 aa. Conserved protein%2Csimilar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0074;product=Conserved protein;protein_id=CCP42797.1;transl_table=11
AL123456.3	EMBL	gene	83996	85168	.	+	.	ID=gene-Rv0075;Name=Rv0075;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0075
AL123456.3	EMBL	CDS	83996	85168	.	+	0	ID=cds-CCP42798.1;Parent=gene-Rv0075;Dbxref=EnsemblGenomes-Gn:Rv0075,EnsemblGenomes-Tr:CCP42798,GOA:O53620,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:O53620,NCBI_GP:CCP42798.1;Name=CCP42798.1;Note=Rv0075%2C (MTV030.19)%2C len: 390 aa. Probable aminotransferase%2C similar to many class-II pyridoxal-phosphate-dependent aminotransferases (MALY/PATB subfamily). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv2294%2C Rv0858c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0075;product=Probable aminotransferase;protein_id=CCP42798.1;transl_table=11
AL123456.3	EMBL	gene	85183	85572	.	-	.	ID=gene-Rv0076c;Name=Rv0076c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0076c
AL123456.3	EMBL	CDS	85183	85572	.	-	0	ID=cds-CCP42799.1;Parent=gene-Rv0076c;Dbxref=EnsemblGenomes-Gn:Rv0076c,EnsemblGenomes-Tr:CCP42799,UniProtKB/TrEMBL:O53621,NCBI_GP:CCP42799.1;Name=CCP42799.1;Note=Rv0076c%2C (MTV030.20c)%2C len: 129 aa. Probable membrane protein%2C with membrane-spanning domain at C-terminus.;gbkey=CDS;locus_tag=Rv0076c;product=Probable membrane protein;protein_id=CCP42799.1;transl_table=11
AL123456.3	EMBL	gene	85636	86466	.	-	.	ID=gene-Rv0077c;Name=Rv0077c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0077c
AL123456.3	EMBL	CDS	85636	86466	.	-	0	ID=cds-CCP42800.1;Parent=gene-Rv0077c;Dbxref=EnsemblGenomes-Gn:Rv0077c,EnsemblGenomes-Tr:CCP42800,GOA:O53622,InterPro:IPR000073,InterPro:IPR029058,UniProtKB/TrEMBL:O53622,NCBI_GP:CCP42800.1;Name=CCP42800.1;Note=Rv0077c%2C (MTV030.21c)%2C len: 276 aa. Possible oxidoreductase%2C weakly similar to others from Streptomyces. Also similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium tuberculosis. And shows some similarity in part with AAL17935.1|AY054120 putative epoxide hydrolase from Mycobacterium smegmatis (203 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0077c;product=Probable oxidoreductase;protein_id=CCP42800.1;transl_table=11
AL123456.3	EMBL	gene	86528	87133	.	+	.	ID=gene-Rv0078;Name=Rv0078;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0078
AL123456.3	EMBL	CDS	86528	87133	.	+	0	ID=cds-CCP42801.1;Parent=gene-Rv0078;Dbxref=EnsemblGenomes-Gn:Rv0078,EnsemblGenomes-Tr:CCP42801,GOA:O53623,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O53623,NCBI_GP:CCP42801.1;Name=CCP42801.1;Note=Rv0078%2C (MTV030.22)%2C len: 201 aa. Probable transcriptional regulator. Contains probable helix-turn-helix motif from aa 35 to 56 (Score 1348%2C +3.78 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0078;product=Probable transcriptional regulatory protein;protein_id=CCP42801.1;transl_table=11
AL123456.3	EMBL	gene	87208	87801	.	-	.	ID=gene-Rv0078A;Name=Rv0078A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0078A
AL123456.3	EMBL	CDS	87208	87801	.	-	0	ID=cds-CCP42802.1;Parent=gene-Rv0078A;Dbxref=EnsemblGenomes-Gn:Rv0078A,EnsemblGenomes-Tr:CCP42802,InterPro:IPR014942,UniProtKB/TrEMBL:L7N686,NCBI_GP:CCP42802.1;Name=CCP42802.1;Note=Rv0078A%2C len: 197 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0078A;product=Hypothetical protein;protein_id=CCP42802.1;transl_table=11
AL123456.3	EMBL	gene	87798	88004	.	-	.	ID=gene-Rv0078B;Name=Rv0078B;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0078B
AL123456.3	EMBL	CDS	87798	88004	.	-	0	ID=cds-CCP42803.1;Parent=gene-Rv0078B;Dbxref=EnsemblGenomes-Gn:Rv0078B,EnsemblGenomes-Tr:CCP42803,UniProtKB/TrEMBL:I6X8G2,NCBI_GP:CCP42803.1;Name=CCP42803.1;Note=Rv0078B%2C len: 68 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0078B;product=Conserved protein;protein_id=CCP42803.1;transl_table=11
AL123456.3	EMBL	gene	88204	89025	.	+	.	ID=gene-Rv0079;Name=Rv0079;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0079
AL123456.3	EMBL	CDS	88204	89025	.	+	0	ID=cds-CCP42804.1;Parent=gene-Rv0079;Dbxref=EnsemblGenomes-Gn:Rv0079,EnsemblGenomes-Tr:CCP42804,GOA:P9WMA9,NCBI_GP:CCP42804.1;Name=CCP42804.1;Note=Rv0079%2C (MTV030.23)%2C len: 273 aa. Unknown protein. Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0079;product=Unknown protein;protein_id=CCP42804.1;transl_table=11
AL123456.3	EMBL	gene	89022	89480	.	+	.	ID=gene-Rv0080;Name=Rv0080;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0080
AL123456.3	EMBL	CDS	89022	89480	.	+	0	ID=cds-CCP42805.1;Parent=gene-Rv0080;Dbxref=EnsemblGenomes-Gn:Rv0080,EnsemblGenomes-Tr:CCP42805,GOA:P9WMA5,InterPro:IPR012349,InterPro:IPR024747,NCBI_GP:CCP42805.1;Name=CCP42805.1;Note=Rv0080%2C (MTV030.24)%2C len: 152 aa. Conserved hypothetical protein. Belongs to pyridoxine 5'-phosphate (PNP) oxidase-like (PNPOx-like) superfamily.;gbkey=CDS;locus_tag=Rv0080;product=Conserved hypothetical protein;protein_id=CCP42805.1;transl_table=11
AL123456.3	EMBL	gene	89575	89919	.	+	.	ID=gene-Rv0081;Name=Rv0081;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0081
AL123456.3	EMBL	CDS	89575	89919	.	+	0	ID=cds-CCP42806.1;Parent=gene-Rv0081;Dbxref=EnsemblGenomes-Gn:Rv0081,EnsemblGenomes-Tr:CCP42806,GOA:P9WMI7,InterPro:IPR001845,InterPro:IPR011991,NCBI_GP:CCP42806.1;Name=CCP42806.1;Note=Rv0081%2C (MTV030.25)%2C len: 114 aa. Probable transcriptional regulator%2C highly similar to others.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0081;product=Probable transcriptional regulatory protein;protein_id=CCP42806.1;transl_table=11
AL123456.3	EMBL	gene	89924	90403	.	+	.	ID=gene-Rv0082;Name=Rv0082;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0082
AL123456.3	EMBL	CDS	89924	90403	.	+	0	ID=cds-CCP42807.1;Parent=gene-Rv0082;Dbxref=EnsemblGenomes-Gn:Rv0082,EnsemblGenomes-Tr:CCP42807,GOA:I6XUD2,InterPro:IPR006137,UniProtKB/TrEMBL:I6XUD2,NCBI_GP:CCP42807.1;Name=CCP42807.1;Note=Rv0082%2C (MTV030.26)%2C len: 159 aa. Probable oxidoreductase%2C highly similar or similar to other various oxidoreductases. Nucleotide position 90144 in the genome sequence has been corrected%2C A:G resulting in Q74R.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0082;product=Probable oxidoreductase;protein_id=CCP42807.1;transl_table=11
AL123456.3	EMBL	gene	90400	92322	.	+	.	ID=gene-Rv0083;Name=Rv0083;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0083
AL123456.3	EMBL	CDS	90400	92322	.	+	0	ID=cds-CCP42808.1;Parent=gene-Rv0083;Dbxref=EnsemblGenomes-Gn:Rv0083,EnsemblGenomes-Tr:CCP42808,GOA:P9WIW3,InterPro:IPR001750,InterPro:IPR003918,NCBI_GP:CCP42808.1;Name=CCP42808.1;Note=Rv0083%2C (MTV030.27%2C MTCY251.01)%2C len: 640 aa. Probable oxidoreductase%2C showing some similarity to other various oxidoreductases. Nucleotide position 91071 in the genome sequence has been corrected%2C T:C resulting in I224I.;gbkey=CDS;locus_tag=Rv0083;product=Probable oxidoreductase;protein_id=CCP42808.1;transl_table=11
AL123456.3	EMBL	gene	92328	93278	.	+	.	ID=gene-Rv0084;Name=hycD;gbkey=Gene;gene=hycD;gene_biotype=protein_coding;gene_synonym=hevD;locus_tag=Rv0084
AL123456.3	EMBL	CDS	92328	93278	.	+	0	ID=cds-CCP42809.1;Parent=gene-Rv0084;Dbxref=EnsemblGenomes-Gn:Rv0084,EnsemblGenomes-Tr:CCP42809,GOA:Q10881,InterPro:IPR001694,UniProtKB/TrEMBL:Q10881,NCBI_GP:CCP42809.1;Name=CCP42809.1;Note=Rv0084%2C (MTCY251.02)%2C len: 316 aa. Possible hycD (alternate gene name: hevD)%2C formate hydrogenlyase%2Cintegral membrane protein%2C similar to others. Belongs to the complex I subunit 1 family.;gbkey=CDS;gene=hycD;locus_tag=Rv0084;product=Possible formate hydrogenlyase HycD (FHL);protein_id=CCP42809.1;transl_table=11
AL123456.3	EMBL	gene	93289	93951	.	+	.	ID=gene-Rv0085;Name=hycP;gbkey=Gene;gene=hycP;gene_biotype=protein_coding;locus_tag=Rv0085
AL123456.3	EMBL	CDS	93289	93951	.	+	0	ID=cds-CCP42810.1;Parent=gene-Rv0085;Dbxref=EnsemblGenomes-Gn:Rv0085,EnsemblGenomes-Tr:CCP42810,GOA:P9WM75,NCBI_GP:CCP42810.1;Name=CCP42810.1;Note=Rv0085%2C (MTCY251.03)%2C len: 220 aa. Possible hycP%2Chydrogenase%2C integral membrane protein. Belongs to NADH-ubiquinone/plastoquinone oxidoreductase chain 4L superfamily.;gbkey=CDS;gene=hycP;locus_tag=Rv0085;product=Possible hydrogenase HycP;protein_id=CCP42810.1;transl_table=11
AL123456.3	EMBL	gene	93951	95417	.	+	.	ID=gene-Rv0086;Name=hycQ;gbkey=Gene;gene=hycQ;gene_biotype=protein_coding;locus_tag=Rv0086
AL123456.3	EMBL	CDS	93951	95417	.	+	0	ID=cds-CCP42811.1;Parent=gene-Rv0086;Dbxref=EnsemblGenomes-Gn:Rv0086,EnsemblGenomes-Tr:CCP42811,GOA:Q10883,InterPro:IPR001750,UniProtKB/TrEMBL:Q10883,NCBI_GP:CCP42811.1;Name=CCP42811.1;Note=Rv0086%2C (MTCY251.04)%2C len: 488 aa. Possible hycQ%2Chydrogenase%2C integral membrane protein. Belongs to the NADH-Ubiquinone/plastoquinone (complex I) superfamily.;gbkey=CDS;gene=hycQ;locus_tag=Rv0086;product=Possible hydrogenase HycQ;protein_id=CCP42811.1;transl_table=11
AL123456.3	EMBL	gene	95414	96892	.	+	.	ID=gene-Rv0087;Name=hycE;gbkey=Gene;gene=hycE;gene_biotype=protein_coding;gene_synonym=hevE;locus_tag=Rv0087
AL123456.3	EMBL	CDS	95414	96892	.	+	0	ID=cds-CCP42812.1;Parent=gene-Rv0087;Dbxref=EnsemblGenomes-Gn:Rv0087,EnsemblGenomes-Tr:CCP42812,GOA:Q10884,InterPro:IPR001135,InterPro:IPR001268,InterPro:IPR001501,InterPro:IPR020396,InterPro:IPR029014,UniProtKB/TrEMBL:Q10884,NCBI_GP:CCP42812.1;Name=CCP42812.1;Note=Rv0087%2C (MTCY251.05)%2C len: 492 aa. Possible hycE (alternate gene name: hevE)%2C formate hydrogenlyase%2C similar to others. Belongs to the complex I 49 kDa subunit family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hycE;locus_tag=Rv0087;product=Possible formate hydrogenase HycE (FHL);protein_id=CCP42812.1;transl_table=11
AL123456.3	EMBL	gene	96927	97601	.	+	.	ID=gene-Rv0088;Name=Rv0088;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0088
AL123456.3	EMBL	CDS	96927	97601	.	+	0	ID=cds-CCP42813.1;Parent=gene-Rv0088;Dbxref=EnsemblGenomes-Gn:Rv0088,EnsemblGenomes-Tr:CCP42813,GOA:P9WM73,InterPro:IPR019587,InterPro:IPR023393,NCBI_GP:CCP42813.1;Name=CCP42813.1;Note=Rv0088%2C (MTCY251.06)%2C len: 224 aa. Possible polyketide cyclase/dehydrase. Belongs to the SRPBCC ligand-binding domain superfamily. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0088;product=Possible polyketide cyclase/dehydrase;protein_id=CCP42813.1;transl_table=11
AL123456.3	EMBL	gene	97758	98351	.	+	.	ID=gene-Rv0089;Name=Rv0089;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0089
AL123456.3	EMBL	CDS	97758	98351	.	+	0	ID=cds-CCP42814.1;Parent=gene-Rv0089;Dbxref=EnsemblGenomes-Gn:Rv0089,EnsemblGenomes-Tr:CCP42814,GOA:P9WK03,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP42814.1;Name=CCP42814.1;Note=Rv0089%2C (MTCY251.07)%2C len: 197 aa. Possible methyltransferase%2C showing some weak similarity to others. Also some similarity with many biotin biosynthesis proteins. Belongs to the methyltransferase superfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0089;product=Possible methyltransferase/methylase;protein_id=CCP42814.1;transl_table=11
AL123456.3	EMBL	gene	98480	99250	.	+	.	ID=gene-Rv0090;Name=Rv0090;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0090
AL123456.3	EMBL	CDS	98480	99250	.	+	0	ID=cds-CCP42815.1;Parent=gene-Rv0090;Dbxref=EnsemblGenomes-Gn:Rv0090,EnsemblGenomes-Tr:CCP42815,GOA:P9WM71,InterPro:IPR014511,InterPro:IPR021125,NCBI_GP:CCP42815.1;Name=CCP42815.1;Note=Rv0090%2C (MTCY251.08)%2C len: 256 aa. Possible membrane protein. Contains IPR014511 Protein of unknown function DUF2068%2C transmembrane%2C subgroup.;gbkey=CDS;locus_tag=Rv0090;product=Possible membrane protein;protein_id=CCP42815.1;transl_table=11
AL123456.3	EMBL	gene	99684	100451	.	+	.	ID=gene-Rv0091;Name=mtn;gbkey=Gene;gene=mtn;gene_biotype=protein_coding;gene_synonym=pfs;locus_tag=Rv0091
AL123456.3	EMBL	CDS	99684	100451	.	+	0	ID=cds-CCP42816.1;Parent=gene-Rv0091;Dbxref=EnsemblGenomes-Gn:Rv0091,EnsemblGenomes-Tr:CCP42816,GOA:P9WJM3,InterPro:IPR000845,InterPro:IPR018017,NCBI_GP:CCP42816.1;Name=CCP42816.1;Note=Rv0091%2C (MTCY251.10)%2C len: 255 aa. Probable mtn (alternate gene name: pfs)%2Cmethylthioadenosine/S-Adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase)%2C including 5'-methylthioadenosine nucleosidase and S-adenosylhomocysteine nucleosidase%2Csimilar to others. Belongs to the MTN family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mtn;locus_tag=Rv0091;product=Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase);protein_id=CCP42816.1;transl_table=11
AL123456.3	EMBL	gene	100583	102868	.	+	.	ID=gene-Rv0092;Name=ctpA;gbkey=Gene;gene=ctpA;gene_biotype=protein_coding;locus_tag=Rv0092
AL123456.3	EMBL	CDS	100583	102868	.	+	0	ID=cds-CCP42817.1;Parent=gene-Rv0092;Dbxref=EnsemblGenomes-Gn:Rv0092,EnsemblGenomes-Tr:CCP42817,GOA:P9WPU1,InterPro:IPR000579,InterPro:IPR001757,InterPro:IPR006121,InterPro:IPR008250,InterPro:IPR017969,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,InterPro:IPR027256,NCBI_GP:CCP42817.1;Name=CCP42817.1;Note=Rv0092%2C (MTCY251.11)%2C len: 761 aa. CtpA%2Ccation-transporting P-type ATPase a (transmembrane protein)%2C highly similar to many. Contains PS01047 Heavy-metal-associated domain%2C and PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases)%2C subfamily IB.;gbkey=CDS;gene=ctpA;inference=protein motif:PROSITE:PS01047;locus_tag=Rv0092;product=Cation transporter P-type ATPase a CtpA;protein_id=CCP42817.1;transl_table=11
AL123456.3	EMBL	gene	102815	103663	.	-	.	ID=gene-Rv0093c;Name=Rv0093c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0093c
AL123456.3	EMBL	CDS	102815	103663	.	-	0	ID=cds-CCP42818.1;Parent=gene-Rv0093c;Dbxref=EnsemblGenomes-Gn:Rv0093c,EnsemblGenomes-Tr:CCP42818,GOA:P9WM69,InterPro:IPR027383,NCBI_GP:CCP42818.1;Name=CCP42818.1;Note=Rv0093c%2C (MTCY251.12c)%2C len: 282 aa. Probable conserved membrane protein%2C equivalent only to CAC30943.1|AL583924 probable integral membrane protein from Mycobacterium leprae (237 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0093c;product=Probable conserved membrane protein;protein_id=CCP42818.1;transl_table=11
AL123456.3	EMBL	gene	103710	104663	.	-	.	ID=gene-Rv0094c;Name=Rv0094c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0094c
AL123456.3	EMBL	CDS	103710	104663	.	-	0	ID=cds-CCP42819.1;Parent=gene-Rv0094c;Dbxref=EnsemblGenomes-Gn:Rv0094c,EnsemblGenomes-Tr:CCP42819,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:Q50655,NCBI_GP:CCP42819.1;Name=CCP42819.1;Note=Rv0094c%2C (MTCY251.13c)%2C len: 317 aa. Member of 13E12 repeat family%2C showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa)%2C FASTA score: (49.4%25 identity in 79 aa overlap).;gbkey=CDS;locus_tag=Rv0094c;product=Conserved hypothetical protein;protein_id=CCP42819.1;transl_table=11
AL123456.3	EMBL	repeat_region	103713	105215	.	-	.	ID=id-AL123456.3:103713..105215;Note=REP-2%2C len: 1503 nt. REP251%2C member of REP13E12 family.;gbkey=repeat_region
AL123456.3	EMBL	gene	104805	105215	.	-	.	ID=gene-Rv0095c;Name=Rv0095c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0095c
AL123456.3	EMBL	CDS	104805	105215	.	-	0	ID=cds-CCP42820.1;Parent=gene-Rv0095c;Dbxref=EnsemblGenomes-Gn:Rv0095c,EnsemblGenomes-Tr:CCP42820,InterPro:IPR003870,NCBI_GP:CCP42820.1;Name=CCP42820.1;Note=Rv0095c%2C (MTCY251.14c)%2C len: 136 aa. Member of 13E12 repeat%2C also partially similar to AF0418|AF041819_8 from Mycobacterium bovis BCG (222 aa)%2C FASTA score: (89.6%25 identity in 96 aa overlap).;gbkey=CDS;locus_tag=Rv0095c;product=Conserved hypothetical protein;protein_id=CCP42820.1;transl_table=11
AL123456.3	EMBL	gene	105324	106715	.	+	.	ID=gene-Rv0096;Name=PPE1;gbkey=Gene;gene=PPE1;gene_biotype=protein_coding;locus_tag=Rv0096
AL123456.3	EMBL	CDS	105324	106715	.	+	0	ID=cds-CCP42821.1;Parent=gene-Rv0096;Dbxref=EnsemblGenomes-Gn:Rv0096,EnsemblGenomes-Tr:CCP42821,GOA:P9WI49,InterPro:IPR000030,NCBI_GP:CCP42821.1;Name=CCP42821.1;Note=Rv0096%2C (MTCY251.15)%2C len: 463 aa. PPE1%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to many. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE1;locus_tag=Rv0096;product=PPE family protein PPE1;protein_id=CCP42821.1;transl_table=11
AL123456.3	EMBL	gene	106734	107603	.	+	.	ID=gene-Rv0097;Name=Rv0097;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0097
AL123456.3	EMBL	CDS	106734	107603	.	+	0	ID=cds-CCP42822.1;Parent=gene-Rv0097;Dbxref=EnsemblGenomes-Gn:Rv0097,EnsemblGenomes-Tr:CCP42822,GOA:P9WG83,InterPro:IPR003819,NCBI_GP:CCP42822.1;Name=CCP42822.1;Note=Rv0097%2C (MTCY251.16)%2C len: 289 aa. Possible oxidoreductase%2C equivalent to NP_302343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (289 aa). Also highly similar to BAB69377.1|AB070955 putative oxidoreductase from Streptomyces avermitilis (296 aa). Contains PS00077 Cytochrome c oxidase subunit I%2C copper B binding region signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00077;locus_tag=Rv0097;product=Possible oxidoreductase;protein_id=CCP42822.1;transl_table=11
AL123456.3	EMBL	gene	107600	108151	.	+	.	ID=gene-Rv0098;Name=fcoT;gbkey=Gene;gene=fcoT;gene_biotype=protein_coding;locus_tag=Rv0098
AL123456.3	EMBL	CDS	107600	108151	.	+	0	ID=cds-CCP42823.1;Parent=gene-Rv0098;Dbxref=EnsemblGenomes-Gn:Rv0098,EnsemblGenomes-Tr:CCP42823,GOA:P9WM67,InterPro:IPR022598,PDB:2PFC,PDB:3B18,NCBI_GP:CCP42823.1;Name=CCP42823.1;Note=Rv0098%2C (MTCY251.17)%2C len: 183 aa. FcoT%2C long-chain fatty acyl CoA thioesterase type III (See Wang et al.%2C2007)%2C equivalent to CAC30948.1|AL583924 from Mycobacterium leprae (183 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fcoT;locus_tag=Rv0098;product=Probable fatty acyl CoA thioesterase type III FcoT;protein_id=CCP42823.1;transl_table=11
AL123456.3	EMBL	gene	108156	109778	.	+	.	ID=gene-Rv0099;Name=fadD10;gbkey=Gene;gene=fadD10;gene_biotype=protein_coding;locus_tag=Rv0099
AL123456.3	EMBL	CDS	108156	109778	.	+	0	ID=cds-CCP42824.1;Parent=gene-Rv0099;Dbxref=EnsemblGenomes-Gn:Rv0099,EnsemblGenomes-Tr:CCP42824,GOA:P9WQ55,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,NCBI_GP:CCP42824.1;Name=CCP42824.1;Note=Rv0099%2C (MTCY251.18)%2C len: 540 aa. Possible fadD10%2Cfatty-acid-CoA synthetase%2C similar to many. Contains PS00455 putative AMP-binding domain signature. Contains IPR000873 AMP-dependent synthetase/ligase domain. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD10;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0099;product=Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP42824.1;transl_table=11
AL123456.3	EMBL	gene	109783	110019	.	+	.	ID=gene-Rv0100;Name=Rv0100;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0100
AL123456.3	EMBL	CDS	109783	110019	.	+	0	ID=cds-CCP42825.1;Parent=gene-Rv0100;Dbxref=EnsemblGenomes-Gn:Rv0100,EnsemblGenomes-Tr:CCP42825,InterPro:IPR009081,NCBI_GP:CCP42825.1;Name=CCP42825.1;Note=Rv0100%2C (MTCY251.19)%2C len: 78 aa. Conserved hypothetical protein%2C equivalent only to CAC30950.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (78 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;gbkey=CDS;locus_tag=Rv0100;product=Conserved hypothetical protein;protein_id=CCP42825.1;transl_table=11
AL123456.3	EMBL	gene	110001	117539	.	+	.	ID=gene-Rv0101;Name=nrp;gbkey=Gene;gene=nrp;gene_biotype=protein_coding;locus_tag=Rv0101
AL123456.3	EMBL	CDS	110001	117539	.	+	0	ID=cds-CCP42826.1;Parent=gene-Rv0101;Dbxref=EnsemblGenomes-Gn:Rv0101,EnsemblGenomes-Tr:CCP42826,GOA:Q10896,InterPro:IPR000873,InterPro:IPR001242,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR010071,InterPro:IPR010080,InterPro:IPR013120,InterPro:IPR016040,InterPro:IPR020845,InterPro:IPR025110,PDB:4DQV,UniProtKB/TrEMBL:Q10896,NCBI_GP:CCP42826.1;Name=CCP42826.1;Note=Rv0101%2C (MTCY251.20)%2C len: 2512 aa. Probable nrp%2Cpeptide synthetase%2C similar to others e.g. AAD44234.1|AF143772_40|PstB peptide synthetase from Mycobacterium avium (2552 aa)%3B 7476034|S77657 cyclic peptide synthetase from Mycobacterium leprae (1401 aa)%2CFASTA scores: opt: 4268%2C E(): 0%2C (65.7%25 identity in 1091 aa overlap)%3B part of CAB55600.1|AJ238027 peptide synthetase from Mycobacterium smegmatis (5990). Also similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF protein from Bacillus subtilis (2378 aa)%3B SRF1_BACSU|P27206 surfactin synthetase subunit 1 (3587 aa)%2C FASTA scores: opt: 1708%2C E(): 0%2C(30.6%25 identity in 1633 aa overlap): etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C 2 x PS00455 Putative AMP-binding domain signature%2C and PS00012 Phosphopantetheine attachment site. Belongs to the ATP-dependent AMP-binding enzyme family. Thought to be not involved in mycobactin biosynthesis (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrp;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0101;product=Probable peptide synthetase Nrp (peptide synthase);protein_id=CCP42826.1;transl_table=11
AL123456.3	EMBL	gene	117714	119699	.	+	.	ID=gene-Rv0102;Name=Rv0102;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0102
AL123456.3	EMBL	CDS	117714	119699	.	+	0	ID=cds-CCP42827.1;Parent=gene-Rv0102;Dbxref=EnsemblGenomes-Gn:Rv0102,EnsemblGenomes-Tr:CCP42827,GOA:P9WM63,InterPro:IPR019108,NCBI_GP:CCP42827.1;Name=CCP42827.1;Note=Rv0102%2C (MTCY251.21)%2C len: 661 aa. Probable conserved integral membrane protein%2C highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium leprae (659 aa)%2C FASTA scores: opt: 3107%2C E(): 0%2C (70.2%25 identity in 662 aa overlap). Also similar to others e.g. CAC01497.1|AL391017 putative integral membrane protein from Streptomyces coelicolor (316 aa)%3B etc. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00343;locus_tag=Rv0102;product=Probable conserved integral membrane protein;protein_id=CCP42827.1;transl_table=11
AL123456.3	EMBL	gene	119915	122173	.	-	.	ID=gene-Rv0103c;Name=ctpB;gbkey=Gene;gene=ctpB;gene_biotype=protein_coding;locus_tag=Rv0103c
AL123456.3	EMBL	CDS	119915	122173	.	-	0	ID=cds-CCP42828.1;Parent=gene-Rv0103c;Dbxref=EnsemblGenomes-Gn:Rv0103c,EnsemblGenomes-Tr:CCP42828,GOA:P9WPT9,InterPro:IPR000579,InterPro:IPR001757,InterPro:IPR006121,InterPro:IPR008250,InterPro:IPR017969,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,InterPro:IPR027256,NCBI_GP:CCP42828.1;Name=CCP42828.1;Note=Rv0103c%2C (MTCY251.22c)%2C len: 752 aa. Probable ctpB%2Ccation-transporting P-type ATPase B (transmembrane protein)%2C equivalent to CTPB_MYCLE|P46840 cation-transporting P-type ATPase B from Mycobacterium leprae (750 aa)%2C FASTA scores: opt: 3615%2C E(): 0%2C (76.5%25 identity in 752 aa overlap). Also highly similar to others e.g. CAB96031.1|AL360055 putative metal transporter ATPase from Streptomyces coelicolor (753 aa)%3B NP_241423.1|NC_002570 copper-transporting ATPase from Bacillus halodurans (806 aa)%3B etc. Also highly similar to Z46257|MLACEA_7 aceA gene for isocitrate L from Mycobacterium leprae (750 aa)%2C FASTA scores: opt: 3615%2CE():0%2C (76.5%25 identity in 752 aa overlap). And similar to MTCY251.11 from Mycobacterium tuberculosis%2C FASTA score: (68.3%25 identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain%2C PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases)%2C subfamily IB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpB;inference=protein motif:PROSITE:PS01047;locus_tag=Rv0103c;product=Probable cation-transporter P-type ATPase B CtpB;protein_id=CCP42828.1;transl_table=11
AL123456.3	EMBL	gene	122317	123831	.	+	.	ID=gene-Rv0104;Name=Rv0104;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0104
AL123456.3	EMBL	CDS	122317	123831	.	+	0	ID=cds-CCP42829.1;Parent=gene-Rv0104;Dbxref=EnsemblGenomes-Gn:Rv0104,EnsemblGenomes-Tr:CCP42829,GOA:P9WM61,InterPro:IPR000595,InterPro:IPR014710,InterPro:IPR016040,InterPro:IPR018490,NCBI_GP:CCP42829.1;Name=CCP42829.1;Note=Rv0104%2C (MTCY251.23)%2C len: 504 aa. Conserved hypothetical protein%2C showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta regulatory subunit from Homo sapiens (380 aa)%3B etc.;gbkey=CDS;locus_tag=Rv0104;product=Conserved hypothetical protein;protein_id=CCP42829.1;transl_table=11
AL123456.3	EMBL	gene	123980	124264	.	-	.	ID=gene-Rv0105c;Name=rpmB1;gbkey=Gene;gene=rpmB1;gene_biotype=protein_coding;locus_tag=Rv0105c
AL123456.3	EMBL	CDS	123980	124264	.	-	0	ID=cds-CCP42830.1;Parent=gene-Rv0105c;Dbxref=EnsemblGenomes-Gn:Rv0105c,EnsemblGenomes-Tr:CCP42830,GOA:P9WHB1,InterPro:IPR001383,InterPro:IPR026569,NCBI_GP:CCP42830.1;Name=CCP42830.1;Note=Rv0105c%2C (MTCY251.24c)%2C len: 94 aa. rpmB1%2C 50S ribosomal protein L28-1%2C highly similar to others e.g. Q9X8K8|R28B_STRCO 50S ribosomal protein L28-2 from Streptomyces coelicolor (78 aa)%3B RL28_ECOLI|P02428 50s ribosomal protein l28 from Escherichia coli (77 aa)%2C FASTA scores: opt: 167%2C E(): 6.2e-06%2C (40.7%25 identity in 59 aa overlap)%3B etc. Also similar to MTCY63A_2 from Mycobacterium tuberculosis. Belongs to the L28P family of ribosomal proteins.;gbkey=CDS;gene=rpmB1;locus_tag=Rv0105c;product=50S ribosomal protein L28-1 RpmB1;protein_id=CCP42830.1;transl_table=11
AL123456.3	EMBL	gene	124374	125570	.	+	.	ID=gene-Rv0106;Name=Rv0106;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0106
AL123456.3	EMBL	CDS	124374	125570	.	+	0	ID=cds-CCP42831.1;Parent=gene-Rv0106;Dbxref=EnsemblGenomes-Gn:Rv0106,EnsemblGenomes-Tr:CCP42831,InterPro:IPR003495,InterPro:IPR011629,InterPro:IPR027417,NCBI_GP:CCP42831.1;Name=CCP42831.1;Note=Rv0106%2C (MTCY251.25)%2C len: 398 aa. Conserved hypothetical protein%2C similar to others e.g. AL049841|SCE9_33 from Streptomyces coelicolor (370 aa)%2CFASTA scores: opt: 282%2C E(): 2.5e-11%2C (32.0%25 identity in 381 aa overlap)%3B etc. Some similarity to P94400 homologue to nitrile hydratase region from Bacillus subtilis (397 aa)%2C FASTA scores: opt: 226%2C E(): 5.4e-08%2C (26.4%25 identity in 405 aa overlap). Also similar to COBW_PSEDE|P29937 FASTA score: (25.3%25 identity in 186 aa overlap)%3B and P47K_PSECL|P31521 47 kDa protein (p47k) (419 aa)%2C FASTA score: (25.9%25 identity in 401 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0106;product=Conserved hypothetical protein;protein_id=CCP42831.1;transl_table=11
AL123456.3	EMBL	gene	125643	130541	.	-	.	ID=gene-Rv0107c;Name=ctpI;gbkey=Gene;gene=ctpI;gene_biotype=protein_coding;locus_tag=Rv0107c
AL123456.3	EMBL	CDS	125643	130541	.	-	0	ID=cds-CCP42832.1;Parent=gene-Rv0107c;Dbxref=EnsemblGenomes-Gn:Rv0107c,EnsemblGenomes-Tr:CCP42832,GOA:P9WPS5,InterPro:IPR001757,InterPro:IPR006068,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023298,InterPro:IPR023299,NCBI_GP:CCP42832.1;Name=CCP42832.1;Note=Rv0107c%2C (MTCY251.26c%2C MTV031.01c)%2C len: 1632 aa. Probable ctpI%2C cation-transporting ATPase I P-type%2C highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium leprae (1609 aa)%3B and similar to others e.g. CAB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa)%3B ATA1_SYNY|P37367 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa)%2C FASTA scores: opt: 603%2C E(): 6.6e-29%2C (32.4%25 identity in 710 aa overlap)%3B etc. Also similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium tuberculosis%2C FASTA score: (34.4%25 identity in 796 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpI;inference=protein motif:PROSITE:PS00154;locus_tag=Rv0107c;product=Probable cation-transporter ATPase I CtpI;protein_id=CCP42832.1;transl_table=11
AL123456.3	EMBL	gene	130895	131104	.	-	.	ID=gene-Rv0108c;Name=Rv0108c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0108c
AL123456.3	EMBL	CDS	130895	131104	.	-	0	ID=cds-CCP42833.1;Parent=gene-Rv0108c;Dbxref=EnsemblGenomes-Gn:Rv0108c,EnsemblGenomes-Tr:CCP42833,GOA:O53630,UniProtKB/TrEMBL:O53630,NCBI_GP:CCP42833.1;Name=CCP42833.1;Note=Rv0108c%2C (MTV031.02c)%2C len: 69 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0108c;product=Hypothetical protein;protein_id=CCP42833.1;transl_table=11
AL123456.3	EMBL	gene	131382	132872	.	+	.	ID=gene-Rv0109;Name=PE_PGRS1;gbkey=Gene;gene=PE_PGRS1;gene_biotype=protein_coding;locus_tag=Rv0109
AL123456.3	EMBL	CDS	131382	132872	.	+	0	ID=cds-CCP42834.1;Parent=gene-Rv0109;Dbxref=EnsemblGenomes-Gn:Rv0109,EnsemblGenomes-Tr:CCP42834,InterPro:IPR000084,UniProtKB/TrEMBL:L0T2H7,NCBI_GP:CCP42834.1;Name=CCP42834.1;Note=Rv0109%2C (MTV031.03c)%2C len: 496 aa. PE_PGRS1%2C Member of the M. tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C 2002)%2C highly similar to many e.g. Q50615|Y0DP_MYCTU hypothetical glycine-rich 40.8 kDa protein from Mycobacterium tuberculosis (498 aa)%2C FASTA scores: opt: 1772%2C E(): 0%2C(57.3%25 identity in 513 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS1;locus_tag=Rv0109;product=PE-PGRS family protein PE_PGRS1;protein_id=CCP42834.1;transl_table=11
AL123456.3	EMBL	gene	133020	133769	.	+	.	ID=gene-Rv0110;Name=Rv0110;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0110
AL123456.3	EMBL	CDS	133020	133769	.	+	0	ID=cds-CCP42835.1;Parent=gene-Rv0110;Dbxref=EnsemblGenomes-Gn:Rv0110,EnsemblGenomes-Tr:CCP42835,GOA:O53632,InterPro:IPR002610,InterPro:IPR022764,UniProtKB/TrEMBL:O53632,NCBI_GP:CCP42835.1;Name=CCP42835.1;Note=Rv0110%2C (MTV031.04)%2C len: 249 aa. Probable conserved integral membrane protein%2C similar to many e.g. AL079308|SCH69_25 from Streptomyces coelicolor (297 aa)%2CFASTA scores: opt: 552%2C E(): 6.1e-29%2C (45.4%25 identity in 251 aa overlap)%3B P54493|YQGP_BACSU hypothetical 56.4 KD protein from Bacillus subtilis (507 aa)%2C FASTA scores: opt: 320%2C E(): 4e-15%2C (32.4%25 identity in 210 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0110;product=Probable conserved integral membrane protein;protein_id=CCP42835.1;transl_table=11
AL123456.3	EMBL	gene	133950	136007	.	+	.	ID=gene-Rv0111;Name=Rv0111;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0111
AL123456.3	EMBL	CDS	133950	136007	.	+	0	ID=cds-CCP42836.1;Parent=gene-Rv0111;Dbxref=EnsemblGenomes-Gn:Rv0111,EnsemblGenomes-Tr:CCP42836,GOA:O53633,InterPro:IPR002656,InterPro:IPR013831,UniProtKB/TrEMBL:O53633,NCBI_GP:CCP42836.1;Name=CCP42836.1;Note=Rv0111%2C (MTV031.05)%2C len: 685 aa. Possible transmembrane acyltransferase%2C equivalent to AA22904.1|AL035300 putative acyltransferase from Mycobacterium leprae (696 aa). Also similar to others e.g. C69975 acyltransferase homolog yrhL from Bacillus subtilis (634 aa)%2C FASTA scores: opt: 520%2C E(): 4e-22%2C (36.4%25 identity in 382 aa overlap). Very similar to Mycobacterium tuberculosis proteins Rv0228%2C Rv1254%2C Rv1565c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0111;product=Possible transmembrane acyltransferase;protein_id=CCP42836.1;transl_table=11
AL123456.3	EMBL	gene	136289	137245	.	+	.	ID=gene-Rv0112;Name=gca;gbkey=Gene;gene=gca;gene_biotype=protein_coding;locus_tag=Rv0112
AL123456.3	EMBL	CDS	136289	137245	.	+	0	ID=cds-CCP42837.1;Parent=gene-Rv0112;Dbxref=EnsemblGenomes-Gn:Rv0112,EnsemblGenomes-Tr:CCP42837,GOA:O53634,InterPro:IPR001509,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:O53634,NCBI_GP:CCP42837.1;Name=CCP42837.1;Note=Rv0112%2C (MTV031.06)%2C len: 318 aa. Possible gca%2CGDP-mannose 4%2C6-dehydratase%2C similar to others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas aeruginosa (323 aa)%2C FASTA scores: opt: 415%2C E(): 4.4e-21%2C (27.0%25 identity in 318 aa overlap). Similar to Rv3634c%2C Rv3784%2Cetc from Mycobacterium tuberculosis. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Seems to belong to the GDP-mannose 4%2C6-dehydratase family. Cofactor: NAD(+). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=gca;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0112;product=Possible GDP-mannose 4%2C6-dehydratase Gca (GDP-D-mannose dehydratase);protein_id=CCP42837.1;transl_table=11
AL123456.3	EMBL	gene	137319	137909	.	+	.	ID=gene-Rv0113;Name=gmhA;gbkey=Gene;gene=gmhA;gene_biotype=protein_coding;gene_synonym=lpcA;locus_tag=Rv0113
AL123456.3	EMBL	CDS	137319	137909	.	+	0	ID=cds-CCP42838.1;Parent=gene-Rv0113;Dbxref=EnsemblGenomes-Gn:Rv0113,EnsemblGenomes-Tr:CCP42838,GOA:P9WGG1,InterPro:IPR001347,InterPro:IPR004515,NCBI_GP:CCP42838.1;Name=CCP42838.1;Note=Rv0113%2C (MTV031.07)%2C len: 196 aa. Probable gmhA (alternate gene name: lpcA)%2C sedoheptulose-7-phosphate isomerase (see citation below)%2C similar to many e.g. AE0005|HPAE000596_11 from Helicobacter pylori (192 aa)%2CFASTA scores: opt: 451%2C E(): 1.9e-24%2C (45.1%25 identity in 162 aa overlap). Belongs to the sis family%2C LPCA subfamily. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=gmhA;locus_tag=Rv0113;product=Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase);protein_id=CCP42838.1;transl_table=11
AL123456.3	EMBL	gene	137941	138513	.	+	.	ID=gene-Rv0114;Name=gmhB;gbkey=Gene;gene=gmhB;gene_biotype=protein_coding;locus_tag=Rv0114
AL123456.3	EMBL	CDS	137941	138513	.	+	0	ID=cds-CCP42839.1;Parent=gene-Rv0114;Dbxref=EnsemblGenomes-Gn:Rv0114,EnsemblGenomes-Tr:CCP42839,GOA:P9WMV3,InterPro:IPR004446,InterPro:IPR006543,InterPro:IPR006549,InterPro:IPR023214,NCBI_GP:CCP42839.1;Name=CCP42839.1;Note=Rv0114%2C (MTV031.08)%2C len: 190 aa. Possible gmhB%2CD-alpha%2Cbeta-D-heptose-1%2C7-biphosphate phosphatase (see citation below)%2C similar to several hypothetical proteins and phosphatases e.g. HIS7_ECOLI|P06987 imidazoleglycerol-phosphate dehydratase (355 aa)%2C FASTA scores: opt: 250%2C E(): 3.6e-11%2C (34.0 %25 identity in 141 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=gmhB;locus_tag=Rv0114;product=Possible D-alpha%2Cbeta-D-heptose-1%2C7-biphosphate phosphatase GmhB (D-glycero-D-manno-heptose 7-phosphate kinase);protein_id=CCP42839.1;transl_table=11
AL123456.3	EMBL	gene	138513	139673	.	+	.	ID=gene-Rv0115;Name=hddA;gbkey=Gene;gene=hddA;gene_biotype=protein_coding;locus_tag=Rv0115
AL123456.3	EMBL	CDS	138513	139673	.	+	0	ID=cds-CCP42840.1;Parent=gene-Rv0115;Dbxref=EnsemblGenomes-Gn:Rv0115,EnsemblGenomes-Tr:CCP42840,GOA:O53637,InterPro:IPR001174,InterPro:IPR006204,InterPro:IPR013750,InterPro:IPR014606,InterPro:IPR014721,InterPro:IPR020568,UniProtKB/TrEMBL:O53637,NCBI_GP:CCP42840.1;Name=CCP42840.1;Note=Rv0115%2C (MTV031.09)%2C len: 386 aa. Possible hddA%2CD-alpha-D-heptose-7-phosphate kinase (see citation below)%2Csimilar to several hypothetical proteins and sugar kinases e.g. AAK27850.1|AF324836_3 D-glycero-D-manno-heptose 7-phosphate kinase from Aneurinibacillus thermoaerophilus (341 aa)%3B AAK80995.1|AE007802_11 Sugar kinase from Clostridium acetobutylicum (364 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=hddA;inference=protein motif:PROSITE:PS00435;locus_tag=Rv0115;product=Possible D-alpha-D-heptose-7-phosphate kinase HddA;protein_id=CCP42840.1;transl_table=11
AL123456.3	EMBL	gene	140267	141022	.	-	.	ID=gene-Rv0116c;Name=ldtA;gbkey=Gene;gene=ldtA;gene_biotype=protein_coding;locus_tag=Rv0116c
AL123456.3	EMBL	CDS	140267	141022	.	-	0	ID=cds-CCP42841.1;Parent=gene-Rv0116c;Dbxref=EnsemblGenomes-Gn:Rv0116c,EnsemblGenomes-Tr:CCP42841,GOA:O53638,InterPro:IPR005490,PDB:4JMN,PDB:4JMX,NCBI_GP:CCP42841.1;Name=CCP42841.1;Note=Rv0116c%2C (MTV031.10c)%2C len: 251 aa. Probable ldtA%2CL%2CD-transpeptidase%2C showing similarity to several hypothetical mycobacterial proteins e.g. Rv1433 from Mycobacterium tuberculosis (271 aa)%3B and Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa)%3B to the C-terminal regions of others like Rv0192 from Mycobacterium tuberculosis (366 aa)%2C FASTA scores: opt: 451%2C E(): 1.7e-21%2C (46.7%25 identity in 270 aa overlap)%3B and Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis cosmid (366 aa)%2C FASTA scores: opt: 699%2C E(): 0%2C (45.7%25 identity in 221 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ldtA;locus_tag=Rv0116c;product=Probable L%2CD-transpeptidase LdtA;protein_id=CCP42841.1;transl_table=11
AL123456.3	EMBL	gene	141200	142144	.	+	.	ID=gene-Rv0117;Name=oxyS;gbkey=Gene;gene=oxyS;gene_biotype=protein_coding;locus_tag=Rv0117
AL123456.3	EMBL	CDS	141200	142144	.	+	0	ID=cds-CCP42842.1;Parent=gene-Rv0117;Dbxref=EnsemblGenomes-Gn:Rv0117,EnsemblGenomes-Tr:CCP42842,GOA:L7N677,InterPro:IPR000847,InterPro:IPR005119,InterPro:IPR011991,UniProtKB/TrEMBL:L7N677,NCBI_GP:CCP42842.1;Name=CCP42842.1;Note=Rv0117%2C (MTV031.11)%2C len: 314 aa. OxyS%2C oxidative stress response protein regulatory protein%2C LysR family (see citation below). Similar to many transcription regulators and OxyR%2C the oxidative stress response protein of many bacteria. Contains LysR family signature at N-terminus. Also contains helix-turn-helix motif at aa 16-37 (Score 1543%2C +4.44 SD). Belongs to the LysR family of transcriptional regulators. OXYR is required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase%2C glutathione-reductase%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=oxyS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv0117;product=Oxidative stress response regulatory protein OxyS;protein_id=CCP42842.1;transl_table=11
AL123456.3	EMBL	gene	142128	143876	.	-	.	ID=gene-Rv0118c;Name=oxcA;gbkey=Gene;gene=oxcA;gene_biotype=protein_coding;locus_tag=Rv0118c
AL123456.3	EMBL	CDS	142128	143876	.	-	0	ID=cds-CCP42843.1;Parent=gene-Rv0118c;Dbxref=EnsemblGenomes-Gn:Rv0118c,EnsemblGenomes-Tr:CCP42843,GOA:O53639,InterPro:IPR011766,InterPro:IPR012000,InterPro:IPR012001,InterPro:IPR017660,InterPro:IPR029035,InterPro:IPR029061,UniProtKB/TrEMBL:O53639,NCBI_GP:CCP42843.1;Name=CCP42843.1;Note=Rv0118c%2C (MTV031.12c)%2C Len: 582 aa. Probable oxcA%2Coxalyl-CoA decarboxylase%2C highly similar to many e.g. P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 probable oxalyl-CoA decarboxylase from Escherichia coli (564 aa)%3B M77128|OXAOXA_1 oxalyl-CoA decarboxylase from Oxalobacter formigenes (568 aa)%2C FASTA scores: opt: 2124%2CE():0%2C (55.6%25 identity in 568 aa overlap). Also similar to mycobacterial IlvB proteins e.g. MLCB1788.46c unknown TPP-requiring enzyme from Mycobacterium leprae (548 aa)%3B and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa)%2CFASTA scores: opt: 831%2C E(): 0%2C (33.9%25 identity in 567 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=oxcA;locus_tag=Rv0118c;product=Probable oxalyl-CoA decarboxylase OxcA;protein_id=CCP42843.1;transl_table=11
AL123456.3	EMBL	gene	144049	145626	.	+	.	ID=gene-Rv0119;Name=fadD7;gbkey=Gene;gene=fadD7;gene_biotype=protein_coding;locus_tag=Rv0119
AL123456.3	EMBL	CDS	144049	145626	.	+	0	ID=cds-CCP42844.1;Parent=gene-Rv0119;Dbxref=EnsemblGenomes-Gn:Rv0119,EnsemblGenomes-Tr:CCP42844,GOA:O07169,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O07169,NCBI_GP:CCP42844.1;Name=CCP42844.1;Note=Rv0119%2C (MTV031.13-MTCI418B.01)%2C len: 525 aa. Probable fadD7%2C fatty-acid-CoA synthetase%2C similar to 4-coumarate:CoA ligase of many organisms e.g. U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus taedaxylem (537 aa)%2C FASTA scores: opt: 483%2C E(): 8.3e-22%2C(28.2%25 identity in 440 aa overlap). Contains PS00455 Putative AMP-binding domain signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD7;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0119;product=Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP42844.1;transl_table=11
AL123456.3	EMBL	gene	145627	147771	.	-	.	ID=gene-Rv0120c;Name=fusA2;gbkey=Gene;gene=fusA2;gene_biotype=protein_coding;gene_synonym=fus2;locus_tag=Rv0120c
AL123456.3	EMBL	CDS	145627	147771	.	-	0	ID=cds-CCP42845.1;Parent=gene-Rv0120c;Dbxref=EnsemblGenomes-Gn:Rv0120c,EnsemblGenomes-Tr:CCP42845,GOA:P9WNM9,InterPro:IPR000640,InterPro:IPR000795,InterPro:IPR003593,InterPro:IPR004161,InterPro:IPR005225,InterPro:IPR005517,InterPro:IPR009000,InterPro:IPR009022,InterPro:IPR014721,InterPro:IPR020568,InterPro:IPR027417,NCBI_GP:CCP42845.1;Name=CCP42845.1;Note=Rv0120c%2C (MTCI418B.02c)%2C len: 714 aa. Probable fusA2 (alternate gene name: fus2)%2C elongation factor G%2C highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia coli (703 aa)%2C FASTA scores: opt: 1049%2C E(): 0%2C (32.5%25 identity in 717 aa overlap). Also similar to fusA1|MTCY210.01 from Mycobacterium tuberculosis FASTA score: (39.1%25 identity in 299 aa overlap)%3B and P30767|EFG_MYCLE elongation factor G (EF-G) from Mycobacterium leprae (701 aa)%2C FASTA score: (31.7%25 identity in 710 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the GTP-binding elongation factor family%2C EF-G/EF-2 subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fusA2;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0120c;product=Probable elongation factor G FusA2 (EF-G);protein_id=CCP42845.1;transl_table=11
AL123456.3	EMBL	gene	147908	148342	.	-	.	ID=gene-Rv0121c;Name=Rv0121c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0121c
AL123456.3	EMBL	CDS	147908	148342	.	-	0	ID=cds-CCP42846.1;Parent=gene-Rv0121c;Dbxref=EnsemblGenomes-Gn:Rv0121c,EnsemblGenomes-Tr:CCP42846,GOA:O07171,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019967,UniProtKB/TrEMBL:O07171,NCBI_GP:CCP42846.1;Name=CCP42846.1;Note=Rv0121c%2C (MTCI418B.03c)%2C len: 144 aa. Conserved protein%2C showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155%2C Rv1875%2C Rv2074%2Cetc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0121c;product=Conserved protein;protein_id=CCP42846.1;transl_table=11
AL123456.3	EMBL	gene	148491	148859	.	+	.	ID=gene-Rv0122;Name=Rv0122;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0122
AL123456.3	EMBL	CDS	148491	148859	.	+	0	ID=cds-CCP42847.1;Parent=gene-Rv0122;Dbxref=EnsemblGenomes-Gn:Rv0122,EnsemblGenomes-Tr:CCP42847,GOA:O07172,UniProtKB/TrEMBL:O07172,NCBI_GP:CCP42847.1;Name=CCP42847.1;Note=Rv0122%2C (MTCI418B.04)%2C len: 122 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0122;product=Hypothetical protein;protein_id=CCP42847.1;transl_table=11
AL123456.3	EMBL	gene	148856	149224	.	+	.	ID=gene-Rv0123;Name=Rv0123;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0123
AL123456.3	EMBL	CDS	148856	149224	.	+	0	ID=cds-CCP42848.1;Parent=gene-Rv0123;Dbxref=EnsemblGenomes-Gn:Rv0123,EnsemblGenomes-Tr:CCP42848,GOA:O07173,InterPro:IPR002145,UniProtKB/TrEMBL:O07173,NCBI_GP:CCP42848.1;Name=CCP42848.1;Note=Rv0123%2C (MTCI418B.05)%2C len: 122 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0123;product=Unknown protein;protein_id=CCP42848.1;transl_table=11
AL123456.3	EMBL	gene	149533	150996	.	+	.	ID=gene-Rv0124;Name=PE_PGRS2;gbkey=Gene;gene=PE_PGRS2;gene_biotype=protein_coding;locus_tag=Rv0124
AL123456.3	EMBL	CDS	149533	150996	.	+	0	ID=cds-CCP42849.1;Parent=gene-Rv0124;Dbxref=EnsemblGenomes-Gn:Rv0124,EnsemblGenomes-Tr:CCP42849,InterPro:IPR000084,UniProtKB/TrEMBL:Q79G08,NCBI_GP:CCP42849.1;Name=CCP42849.1;Note=Rv0124%2C (MTCI418B.06)%2C len: 487 aa. PE_PGRS2%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C 2002)%2C highly similar to many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa)%2C FASTA scores: opt: 1730%2C E(): 0%2C(60.7%25 identity in 504 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS2;locus_tag=Rv0124;product=PE-PGRS family protein PE_PGRS2;protein_id=CCP42849.1;transl_table=11
AL123456.3	EMBL	gene	151148	152215	.	+	.	ID=gene-Rv0125;Name=pepA;gbkey=Gene;gene=pepA;gene_biotype=protein_coding;gene_synonym=mtb32a;locus_tag=Rv0125
AL123456.3	EMBL	CDS	151148	152215	.	+	0	ID=cds-CCP42850.1;Parent=gene-Rv0125;Dbxref=EnsemblGenomes-Gn:Rv0125,EnsemblGenomes-Tr:CCP42850,GOA:O07175,InterPro:IPR001478,InterPro:IPR001940,InterPro:IPR006311,InterPro:IPR009003,UniProtKB/TrEMBL:O07175,NCBI_GP:CCP42850.1;Name=CCP42850.1;Note=Rv0125%2C (MTCI418B.07%2C MTB32A)%2C len: 355 aa. Probable pepA (alternate gene name: mtb32a)%2C serine protease (see Skeiky et al.%2C 1999)%2C highly similar to other proteases e.g. HHOB_ECOLI|P31137 protease hhob precursor (355 aa)%2CFASTA scores: opt: 400%2C E(): 3.8e-14%2C (32.4%25 identity in 346 aa overlap). Also similar to Q50320 34 kDa protein precursor from Mycobacterium tuberculosis (361 aa)%2C FASTA scores: opt: 1689%2C E(): 0%2C (70.7%25 identity in 362 aa overlap). Contains PS00135 Serine proteases%2C trypsin family%2C serine active site. Has a putative signal sequence at the N-terminus. Belongs to the serine protease family. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepA;inference=protein motif:PROSITE:PS00135;locus_tag=Rv0125;product=Probable serine protease PepA (serine proteinase) (MTB32A);protein_id=CCP42850.1;transl_table=11
AL123456.3	EMBL	gene	152324	154129	.	+	.	ID=gene-Rv0126;Name=treS;gbkey=Gene;gene=treS;gene_biotype=protein_coding;locus_tag=Rv0126
AL123456.3	EMBL	CDS	152324	154129	.	+	0	ID=cds-CCP42851.1;Parent=gene-Rv0126;Dbxref=EnsemblGenomes-Gn:Rv0126,EnsemblGenomes-Tr:CCP42851,GOA:P9WQ19,InterPro:IPR006047,InterPro:IPR006589,InterPro:IPR012810,InterPro:IPR013780,InterPro:IPR013781,InterPro:IPR015902,InterPro:IPR017853,InterPro:IPR022567,NCBI_GP:CCP42851.1;Name=CCP42851.1;Note=Rv0126%2C (MTCI418B.08)%2C len: 601 aa. TreS%2C trehalose synthase (see citation below)%2C highly similar to others e.g. CAA04601.2|AJ001205 putative trehalose synthase from Streptomyces coelicolor (566 aa)%3B S71450|1536814|BAA11303.1|D78198 trehalose synthase maltose-specific from Pimelobacter sp. strain R48 (573 aa). Also similar to MAL1_DROME|P07191 possible maltase precursor (508 aa)%2C FASTA scores: opt: 807%2C E(): 0%2C (33.7%25 identity in 504 aa overlap)%3B and similar to proteins associated with amino-acid transport e.g. Q64319 rat protein which stimulates transport of cystine and dibasic and neutral amino acids (683 aa)%2C FASTA scores: opt: 839%2CE(): 0%2C (32.0%25 identity in 531 aa overlap). Also similar to several other Mycobacterium tuberculosis proteins e.g. Rv2471 FASTA score: (31.7%25 identity in 164 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=treS;locus_tag=Rv0126;product=Trehalose synthase TreS;protein_id=CCP42851.1;transl_table=11
AL123456.3	EMBL	repeat_region	154073	154125	.	+	.	ID=id-Rv0126;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass III (see Supply et al.%2C 1997);gbkey=repeat_region;gene=treS;locus_tag=Rv0126
AL123456.3	EMBL	repeat_region	154126	154178	.	+	.	ID=id-AL123456.3:154126..154178;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	154179	154231	.	+	.	ID=id-AL123456.3:154179..154231;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	154232	155599	.	+	.	ID=gene-Rv0127;Name=mak;gbkey=Gene;gene=mak;gene_biotype=protein_coding;locus_tag=Rv0127
AL123456.3	EMBL	CDS	154232	155599	.	+	0	ID=cds-CCP42852.1;Parent=gene-Rv0127;Dbxref=EnsemblGenomes-Gn:Rv0127,EnsemblGenomes-Tr:CCP42852,GOA:O07177,InterPro:IPR002575,InterPro:IPR011009,NCBI_GP:CCP42852.1;Name=CCP42852.1;Note=Rv0127%2C (MTCI418B.09%2C MTCI5.01)%2C len: 455 aa. Mak%2Cmaltokinase%3B highly similar to various proteins e.g. AJ0012|SCJ001205_4 hypothetical protein from Streptomyces coelicolor A3(2) (464 aa)%2C FASTA scores: opt: 412%2C E(): 1.1e-19%2C (40.6%25 identity in 485 aa overlap)%3B AJ0012|SCJ001206_5 hypothetical protein from Streptomyces coelicolor A3(2) (453 aa)%2C FASTA scores: opt: 403%2C E(): 4.3 e-19%2C (36.5%25 identity in 455 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mak;locus_tag=Rv0127;product=Maltokinase Mak;protein_id=CCP42852.1;transl_table=11
AL123456.3	EMBL	gene	155667	156446	.	+	.	ID=gene-Rv0128;Name=Rv0128;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0128
AL123456.3	EMBL	CDS	155667	156446	.	+	0	ID=cds-CCP42853.1;Parent=gene-Rv0128;Dbxref=EnsemblGenomes-Gn:Rv0128,EnsemblGenomes-Tr:CCP42853,GOA:P96805,InterPro:IPR010699,UniProtKB/TrEMBL:P96805,NCBI_GP:CCP42853.1;Name=CCP42853.1;Note=Rv0128%2C (MTCI5.02)%2C len: 259 aa. Probable conserved transmembrane protein%2C with some similarity to Rv3064c and other bacterial proteins e.g. AAK85977.1|AE007957|AGR_C_254p from Agrobacterium tumefaciens (206 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0128;product=Probable conserved transmembrane protein;protein_id=CCP42853.1;transl_table=11
AL123456.3	EMBL	gene	156578	157600	.	-	.	ID=gene-Rv0129c;Name=fbpC;gbkey=Gene;gene=fbpC;gene_biotype=protein_coding;gene_synonym=85C,fbpC2,mpt45;locus_tag=Rv0129c
AL123456.3	EMBL	CDS	156578	157600	.	-	0	ID=cds-CCP42854.1;Parent=gene-Rv0129c;Dbxref=EnsemblGenomes-Gn:Rv0129c,EnsemblGenomes-Tr:CCP42854,GOA:P9WQN9,InterPro:IPR000801,InterPro:IPR029058,PDB:1DQY,PDB:1DQZ,PDB:1VA5,PDB:3HRH,PDB:4MQL,PDB:4MQM,PDB:4QDO,PDB:4QDT,PDB:4QDU,PDB:4QDX,PDB:4QDZ,PDB:4QE3,PDB:4QEK,NCBI_GP:CCP42854.1;Name=CCP42854.1;Note=Rv0129c%2C (MT0137%2C MTCI5.03c)%2C len: 340 aa. FbpC (alternate gene names: mpt45%2C 85C%2C fbpC2)%2C secreted antigen 85c (fibronectin-binding protein C) (mycolyl transferase 85C) (see citations below)%2C also highly similar to other Mycobacterial antigen precursors e.g. A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from Mycobacterium leprae (333 aa)%2C FASTA scores: opt: 1937%2C E(): 0%2C (81.4%25 identity in 333 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fbpC;locus_tag=Rv0129c;product=Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C);protein_id=CCP42854.1;transl_table=11
AL123456.3	EMBL	gene	157847	158302	.	+	.	ID=gene-Rv0130;Name=htdZ;gbkey=Gene;gene=htdZ;gene_biotype=protein_coding;locus_tag=Rv0130
AL123456.3	EMBL	CDS	157847	158302	.	+	0	ID=cds-CCP42855.1;Parent=gene-Rv0130;Dbxref=EnsemblGenomes-Gn:Rv0130,EnsemblGenomes-Tr:CCP42855,GOA:P9WNP3,InterPro:IPR002539,InterPro:IPR029069,PDB:2C2I,NCBI_GP:CCP42855.1;Name=CCP42855.1;Note=Rv0130%2C (MTCI5.04)%2C len: 151 aa. Probable htdZ%2C3-hydroxyl-thioester dehydratase. Forms single hot-dog fold%2C features R-specific hydratase motif%2C substrate unknown%2C forms homodimer. Shows structural similarity to six others in Mycobacterium tuberculosis (see Castell et al (2005) below). Similar to others e.g. AL096811|SCI30A_19 from Streptomyces coelicolor (153 aa)%2C FASTA scores: opt: 639%2C E(): 0%2C (60.8%25 identity in 148 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=htdZ;locus_tag=Rv0130;product=Probable 3-hydroxyl-thioester dehydratase;protein_id=CCP42855.1;transl_table=11
AL123456.3	EMBL	gene	158315	159658	.	-	.	ID=gene-Rv0131c;Name=fadE1;gbkey=Gene;gene=fadE1;gene_biotype=protein_coding;locus_tag=Rv0131c
AL123456.3	EMBL	CDS	158315	159658	.	-	0	ID=cds-CCP42856.1;Parent=gene-Rv0131c;Dbxref=EnsemblGenomes-Gn:Rv0131c,EnsemblGenomes-Tr:CCP42856,GOA:P96808,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P96808,NCBI_GP:CCP42856.1;Name=CCP42856.1;Note=Rv0131c%2C (MTCI5.05c)%2C len: 447 aa. Probable fadE1%2Cacyl-CoA dehydrogenase%2C similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain specific precursor (412 aa)%2C FASTA scores: opt: 522%2C E(): 1.4e-23%2C (30.1%25 identity in 425 aa overlap). Also highly similar to MTCI5_28 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE1;locus_tag=Rv0131c;product=Probable acyl-CoA dehydrogenase FadE1;protein_id=CCP42856.1;transl_table=11
AL123456.3	EMBL	gene	159700	160782	.	-	.	ID=gene-Rv0132c;Name=fgd2;gbkey=Gene;gene=fgd2;gene_biotype=protein_coding;locus_tag=Rv0132c
AL123456.3	EMBL	CDS	159700	160782	.	-	0	ID=cds-CCP42857.1;Parent=gene-Rv0132c;Dbxref=EnsemblGenomes-Gn:Rv0132c,EnsemblGenomes-Tr:CCP42857,GOA:P96809,InterPro:IPR011251,InterPro:IPR019945,UniProtKB/TrEMBL:P96809,NCBI_GP:CCP42857.1;Name=CCP42857.1;Note=Rv0132c%2C (MTCI5.06c)%2C len: 360 aa. Putative fgd2%2CF420-dependent glucose-6-phosphate dehydrogenase%2C highly similar to many from Mycobacteria e.g. AAD38167|g5031431 from Mycobacterium chelonae. Also similar to MJ1534|Q58929 N5%2CN10-methylene tetrahydromethanopterin reductase from methanococcus jannaschii (342 aa)%2C FASTA scores: opt: 285%2CE(): 7.9e-11%2C (28.4%25 identity in 292 aa overlap). And also similar to Rv0953c%2C Rv0791c%2C etc from Mycobacterium tuberculosis. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fgd2;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0132c;product=Putative F420-dependent glucose-6-phosphate dehydrogenase Fgd2;protein_id=CCP42857.1;transl_table=11
AL123456.3	EMBL	gene	160869	161474	.	+	.	ID=gene-Rv0133;Name=Rv0133;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0133
AL123456.3	EMBL	CDS	160869	161474	.	+	0	ID=cds-CCP42858.1;Parent=gene-Rv0133;Dbxref=EnsemblGenomes-Gn:Rv0133,EnsemblGenomes-Tr:CCP42858,GOA:P96810,InterPro:IPR000182,InterPro:IPR016181,UniProtKB/TrEMBL:P96810,NCBI_GP:CCP42858.1;Name=CCP42858.1;Note=Rv0133%2C (MTCI5.07)%2C len: 201 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005. Highly similar to others e.g. PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199 aa)%2CFASTA scores: opt: 341%2C E(): 1.8e-16%2C (33.3%25 identity in 201 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0133;product=GCN5-related N-acetyltransferase;protein_id=CCP42858.1;transl_table=11
AL123456.3	EMBL	gene	161771	162673	.	+	.	ID=gene-Rv0134;Name=ephF;gbkey=Gene;gene=ephF;gene_biotype=protein_coding;locus_tag=Rv0134
AL123456.3	EMBL	CDS	161771	162673	.	+	0	ID=cds-CCP42859.1;Parent=gene-Rv0134;Dbxref=EnsemblGenomes-Gn:Rv0134,EnsemblGenomes-Tr:CCP42859,GOA:P96811,InterPro:IPR000639,InterPro:IPR029058,UniProtKB/TrEMBL:P96811,NCBI_GP:CCP42859.1;Name=CCP42859.1;Note=Rv0134%2C (MTCI5.08)%2C len: 300 aa. Possible ephE%2Cepoxide hydrolase (see citation below)%2C similar to others e.g. Q39856 epoxide hydrolase (341 aa)%2C FASTA scores: opt: 369%2C E(): 4.6e-17%2C (27.2%25 identity in 335 aa overlap)%3B etc. Also similar to MTCY09F9.26c from Mycobacterium tuberculosis (29.5%25 identity in 346 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ephF;locus_tag=Rv0134;product=Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase);protein_id=CCP42859.1;transl_table=11
AL123456.3	EMBL	gene	162644	163249	.	-	.	ID=gene-Rv0135c;Name=Rv0135c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0135c
AL123456.3	EMBL	CDS	162644	163249	.	-	0	ID=cds-CCP42860.1;Parent=gene-Rv0135c;Dbxref=EnsemblGenomes-Gn:Rv0135c,EnsemblGenomes-Tr:CCP42860,GOA:P96812,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:P96812,NCBI_GP:CCP42860.1;Name=CCP42860.1;Note=Rv0135c%2C (MTCI5.09c)%2C len: 201 aa. Possible transcriptional regulator%2C weakly similar to others e.g. P32398|YHGD_BACSU hypothetical transcriptional regulator from Bacillus subtilis (191 aa)%2C FASTA scores: opt: 145%2CE(): 0.0012%2C (21.0%25 identity in 162 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0135c;product=Possible transcriptional regulatory protein;protein_id=CCP42860.1;transl_table=11
AL123456.3	EMBL	gene	163366	164691	.	+	.	ID=gene-Rv0136;Name=cyp138;gbkey=Gene;gene=cyp138;gene_biotype=protein_coding;locus_tag=Rv0136
AL123456.3	EMBL	CDS	163366	164691	.	+	0	ID=cds-CCP42861.1;Parent=gene-Rv0136;Dbxref=EnsemblGenomes-Gn:Rv0136,EnsemblGenomes-Tr:CCP42861,GOA:P9WPM3,InterPro:IPR001128,InterPro:IPR002401,InterPro:IPR017972,NCBI_GP:CCP42861.1;Name=CCP42861.1;Note=Rv0136%2C (MT0144%2C MTCI5.10)%2C len: 441 aa. Probable cyp138%2C cytochrome P450 138%2C similar to others e.g. SLR0574|Q59990 from synechocystis SP. (444 aa)%2C FASTA scores: opt: 315%2C E(): 1e-13%2C (25.7%25 identity in 416 aa overlap)%3B etc. Also similar to MTV039_6 from Mycobacterium tuberculosis (472 aa)%2C FASTA score: (38.2%25 identity in 442 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%3B and PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp138;inference=protein motif:PROSITE:PS00086;locus_tag=Rv0136;product=Probable cytochrome P450 138 Cyp138;protein_id=CCP42861.1;transl_table=11
AL123456.3	EMBL	gene	164712	165260	.	-	.	ID=gene-Rv0137c;Name=msrA;gbkey=Gene;gene=msrA;gene_biotype=protein_coding;locus_tag=Rv0137c
AL123456.3	EMBL	CDS	164712	165260	.	-	0	ID=cds-CCP42862.1;Parent=gene-Rv0137c;Dbxref=EnsemblGenomes-Gn:Rv0137c,EnsemblGenomes-Tr:CCP42862,GOA:P9WJM5,InterPro:IPR002569,InterPro:IPR028427,PDB:1NWA,NCBI_GP:CCP42862.1;Name=CCP42862.1;Note=Rv0137c%2C (MTCI5.11c)%2C len: 182 aa. Probable msrA%2Cpeptide methionine sulfoxide reductase (See St. John et al.%2C 2001)%2C equivalent to CAC32179.1|AL583926 putative peptide methionine sulfoxide from Mycobacterium leprae (177 aa). Highly similar to others e.g. CAC18703.1|AL451182 putative peptide methionine sulfoxide reductase from Streptomyces coelicolor (172 aa)%3B PMSR_SCHPO|Q09859 putative peptide methionine sulfoxide reductase from Streptomyces (187 aa)%2C FASTA scores: opt: 468%2C E(): 9.9e-26%2C (45.6%25 identity in 158 aa overlap)%3B etc. Belongs to the MsrA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=msrA;locus_tag=Rv0137c;product=Probable peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide reductase) (peptide met(O) reductase);protein_id=CCP42862.1;transl_table=11
AL123456.3	EMBL	gene	165323	165826	.	+	.	ID=gene-Rv0138;Name=Rv0138;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0138
AL123456.3	EMBL	CDS	165323	165826	.	+	0	ID=cds-CCP42863.1;Parent=gene-Rv0138;Dbxref=EnsemblGenomes-Gn:Rv0138,EnsemblGenomes-Tr:CCP42863,InterPro:IPR009959,UniProtKB/TrEMBL:P96815,NCBI_GP:CCP42863.1;Name=CCP42863.1;Note=Rv0138%2C (MTCI5.12)%2C len: 167 aa. Conserved hypothetical protein%2C showing weak similarity to Q10827|YT10_MYCTU hypothetical 17.0 KDA protein from Mycobacterium tuberculosis (147 aa)%2C FASTA scores: opt: 131%2C E(): 0.047%2C (31.15%25 identity in 106 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0138;product=Conserved hypothetical protein;protein_id=CCP42863.1;transl_table=11
AL123456.3	EMBL	gene	165827	166849	.	+	.	ID=gene-Rv0139;Name=Rv0139;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0139
AL123456.3	EMBL	CDS	165827	166849	.	+	0	ID=cds-CCP42864.1;Parent=gene-Rv0139;Dbxref=EnsemblGenomes-Gn:Rv0139,EnsemblGenomes-Tr:CCP42864,GOA:P96816,InterPro:IPR001509,InterPro:IPR016040,UniProtKB/TrEMBL:P96816,NCBI_GP:CCP42864.1;Name=CCP42864.1;Note=Rv0139%2C (MTCI5.13)%2C len: 340 aa. Possible oxidoreductase%2C similar to others e.g. O34285|HPNA HPNA protein from Zymomonas mobilis (337 aa)%2C FASTA scores: opt: 507%2C E (): 5.8e-27%2C (31.1%25 identity in 328 aa overlap)%3B TRE_STRGR|P29782 dtdp-glucose 4%2C6-dehydratase (328 aa)%2CFASTA scores: opt: 254%2C E(): 2.6e-10%2C (29.0%25 identity in 307 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0139;product=Possible oxidoreductase;protein_id=CCP42864.1;transl_table=11
AL123456.3	EMBL	gene	166910	167290	.	+	.	ID=gene-Rv0140;Name=Rv0140;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0140
AL123456.3	EMBL	CDS	166910	167290	.	+	0	ID=cds-CCP42865.1;Parent=gene-Rv0140;Dbxref=EnsemblGenomes-Gn:Rv0140,EnsemblGenomes-Tr:CCP42865,GOA:P96817,InterPro:IPR007361,UniProtKB/TrEMBL:P96817,NCBI_GP:CCP42865.1;Name=CCP42865.1;Note=Rv0140%2C (MTCI5.14)%2C len: 126 aa. Conserved protein%2Csimilar to others e.g. P74567|D90916_48 hypothetical 20.8 KDP protein from Synechocystis sp. (180 aa)%2C FASTA scores: opt: 229%2C E(): 4.7e-10%2C (36.1%25 identity in 108 aa overlap). Also similar to Rv1056 and Rv1670 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0140;product=Conserved protein;protein_id=CCP42865.1;transl_table=11
AL123456.3	EMBL	gene	167271	167681	.	-	.	ID=gene-Rv0141c;Name=Rv0141c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0141c
AL123456.3	EMBL	CDS	167271	167681	.	-	0	ID=cds-CCP42866.1;Parent=gene-Rv0141c;Dbxref=EnsemblGenomes-Gn:Rv0141c,EnsemblGenomes-Tr:CCP42866,InterPro:IPR009959,UniProtKB/TrEMBL:P96818,NCBI_GP:CCP42866.1;Name=CCP42866.1;Note=Rv0141c%2C (MTCI5.15c)%2C len: 136 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0141c;product=Unknown protein;protein_id=CCP42866.1;transl_table=11
AL123456.3	EMBL	gene	167711	168637	.	+	.	ID=gene-Rv0142;Name=Rv0142;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0142
AL123456.3	EMBL	CDS	167711	168637	.	+	0	ID=cds-CCP42867.1;Parent=gene-Rv0142;Dbxref=EnsemblGenomes-Gn:Rv0142,EnsemblGenomes-Tr:CCP42867,GOA:P96819,InterPro:IPR011257,UniProtKB/TrEMBL:P96819,NCBI_GP:CCP42867.1;Name=CCP42867.1;Note=Rv0142%2C (MTCI5.16)%2C len: 308 aa. Conserved hypothetical protein%2C similar%2C except in N-terminus%2C to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa).;gbkey=CDS;locus_tag=Rv0142;product=Conserved hypothetical protein;protein_id=CCP42867.1;transl_table=11
AL123456.3	EMBL	gene	168704	170182	.	-	.	ID=gene-Rv0143c;Name=Rv0143c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0143c
AL123456.3	EMBL	CDS	168704	170182	.	-	0	ID=cds-CCP42868.1;Parent=gene-Rv0143c;Dbxref=EnsemblGenomes-Gn:Rv0143c,EnsemblGenomes-Tr:CCP42868,GOA:P96820,InterPro:IPR001807,InterPro:IPR014743,UniProtKB/TrEMBL:P96820,NCBI_GP:CCP42868.1;Name=CCP42868.1;Note=Rv0143c%2C (MTCI5.17c)%2C len: 492 aa. Probable conserved transmembrane protein%2C CIC family possibly involved in transport of chloride%2C similar to others and hypothetical proteins e.g. O28857 putative chloride channel from Archaeoglobus fulgidus (589 aa)%2C FASTA scores: opt: 966%2C E(): 0%2C (37.7%25 identity in 453 aa overlap)%3B YADQ_ECOLI|P37019 hypothetical 46.0 kDa protein (436 aa)%2CFASTA scores: opt: 452%2C E(): 2.4e-20%2C (28.0%25 identity in 460 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0143c;product=Probable conserved transmembrane protein;protein_id=CCP42868.1;transl_table=11
AL123456.3	EMBL	gene	170284	171126	.	+	.	ID=gene-Rv0144;Name=Rv0144;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0144
AL123456.3	EMBL	CDS	170284	171126	.	+	0	ID=cds-CCP42869.1;Parent=gene-Rv0144;Dbxref=EnsemblGenomes-Gn:Rv0144,EnsemblGenomes-Tr:CCP42869,GOA:P96821,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:P96821,NCBI_GP:CCP42869.1;Name=CCP42869.1;Note=Rv0144%2C (MTCI5.18)%2C len: 280 aa. Probable transcriptional regulator%2C possibly TetR family. Has region similar to others e.g. Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID operon repressor (GUS operon) from Escherichia coli strains K12 and O157:H7 (196 aa)%2C FASTA scores: opt: 214%2C E(): 1.1e-06%2C(26.0%25 identity in 196 aa overlap). Contains probable helix-turn helix motif from aa 109-130 (Score 1463%2C +4.17 SD). Could belong to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0144;product=Probable transcriptional regulatory protein (possibly TetR-family);protein_id=CCP42869.1;transl_table=11
AL123456.3	EMBL	gene	171215	172168	.	+	.	ID=gene-Rv0145;Name=Rv0145;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0145
AL123456.3	EMBL	CDS	171215	172168	.	+	0	ID=cds-CCP42870.1;Parent=gene-Rv0145;Dbxref=EnsemblGenomes-Gn:Rv0145,EnsemblGenomes-Tr:CCP42870,GOA:P9WFJ1,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP42870.1;Name=CCP42870.1;Note=Rv0145%2C (MTCI5.19)%2C len: 317 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C highly similar to many e.g. CAC32172.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (310 aa)%3B and several Mycobacterium tuberculosis proteins e.g. Rv0726c%2C Rv0731c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0145;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP42870.1;transl_table=11
AL123456.3	EMBL	gene	172211	173143	.	+	.	ID=gene-Rv0146;Name=Rv0146;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0146
AL123456.3	EMBL	CDS	172211	173143	.	+	0	ID=cds-CCP42871.1;Parent=gene-Rv0146;Dbxref=EnsemblGenomes-Gn:Rv0146,EnsemblGenomes-Tr:CCP42871,GOA:P9WFJ3,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP42871.1;Name=CCP42871.1;Note=Rv0146%2C (MTCI5.20)%2C len: 310 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C highly similar to others e.g. AC30975.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (304 aa)%3B and several Mycobacterium tuberculosis proteins e.g. Rv0726c%2C Rv0731c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0146;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP42871.1;transl_table=11
AL123456.3	EMBL	gene	173238	174758	.	+	.	ID=gene-Rv0147;Name=Rv0147;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0147
AL123456.3	EMBL	CDS	173238	174758	.	+	0	ID=cds-CCP42872.1;Parent=gene-Rv0147;Dbxref=EnsemblGenomes-Gn:Rv0147,EnsemblGenomes-Tr:CCP42872,GOA:P96824,InterPro:IPR012394,InterPro:IPR015590,InterPro:IPR016160,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR029510,UniProtKB/TrEMBL:P96824,NCBI_GP:CCP42872.1;Name=CCP42872.1;Note=Rv0147%2C (MTCI5.21)%2C len: 506 aa. Probable aldehyde dehydrogenase (NAD+) dependent%2C similar to others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric NADP-preferring) (452 aa)%2C FASTA scores: opt: 1291%2C E(): 0%2C(43.9%25 identity in 453 aa overlap). Also similar to several Mycobacterium tuberculosis aldehyde dehydrogenases e.g. Rv0768%2C Rv2858c%2C etc. Contains PS00687 aldehyde dehydrogenases glutamic acid active site%2C and PS00070 aldehyde dehydrogenases cysteine active site. Belongs to the aldehyde dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00687;locus_tag=Rv0147;product=Probable aldehyde dehydrogenase (NAD+) dependent;protein_id=CCP42872.1;transl_table=11
AL123456.3	EMBL	gene	174833	175693	.	+	.	ID=gene-Rv0148;Name=Rv0148;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0148
AL123456.3	EMBL	CDS	174833	175693	.	+	0	ID=cds-CCP42873.1;Parent=gene-Rv0148;Dbxref=EnsemblGenomes-Gn:Rv0148,EnsemblGenomes-Tr:CCP42873,GOA:P96825,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP42873.1;Name=CCP42873.1;Note=Rv0148%2C (MTCI5.22)%2C len: 286 aa. Probable short-chain dehydrogenase%2C similar to others%2C in particular Estradiol 17 beta-dehydrogenases%2C e.g. DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 (735 aa)%2C FASTA scores: opt: 952%2C E(): 0%2C (52.5%25 identity in 276 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0148;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP42873.1;transl_table=11
AL123456.3	EMBL	gene	175700	176668	.	+	.	ID=gene-Rv0149;Name=Rv0149;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0149
AL123456.3	EMBL	CDS	175700	176668	.	+	0	ID=cds-CCP42874.1;Parent=gene-Rv0149;Dbxref=EnsemblGenomes-Gn:Rv0149,EnsemblGenomes-Tr:CCP42874,GOA:P96826,InterPro:IPR002085,InterPro:IPR002364,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,UniProtKB/TrEMBL:P96826,NCBI_GP:CCP42874.1;Name=CCP42874.1;Note=Rv0149%2C (MTCI5.23)%2C len: 322 aa. Possible quinone oxidoreductase%2C similar to others oxidoreductases e.g. Q08257 quinone oxidoreductase (329 aa)%2C FASTA scores: opt: 397%2C E(): 3.2e-18%2C (28.4%25 identity in 328 aa overlap)%3B SCHCOADH_4 from Streptomyces coelicolor. Also similar to many proteins from Mycobacterium tuberculosis. Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. Belongs to the zinc-containing alcohol dehydrogenase family%2C quinone oxidoreductase subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01162;locus_tag=Rv0149;product=Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin);protein_id=CCP42874.1;transl_table=11
AL123456.3	EMBL	gene	176665	176952	.	-	.	ID=gene-Rv0150c;Name=Rv0150c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0150c
AL123456.3	EMBL	CDS	176665	176952	.	-	0	ID=cds-CCP42875.1;Parent=gene-Rv0150c;Dbxref=EnsemblGenomes-Gn:Rv0150c,EnsemblGenomes-Tr:CCP42875,UniProtKB/TrEMBL:P96827,NCBI_GP:CCP42875.1;Name=CCP42875.1;Note=Rv0150c%2C (MTCI5.24c)%2C len: 95 aa. Conserved hypothetical protein%2C showing some similarity with C-terminus of O53949|Rv1800|MTV049.22 PPE-family protein from Mycobacterium tuberculosis (655 aa)%2C FASTA score: (36.5%25 identity in 104 aa overlap).;gbkey=CDS;locus_tag=Rv0150c;product=Conserved hypothetical protein;protein_id=CCP42875.1;transl_table=11
AL123456.3	EMBL	gene	177543	179309	.	-	.	ID=gene-Rv0151c;Name=PE1;gbkey=Gene;gene=PE1;gene_biotype=protein_coding;locus_tag=Rv0151c
AL123456.3	EMBL	CDS	177543	179309	.	-	0	ID=cds-CCP42876.1;Parent=gene-Rv0151c;Dbxref=EnsemblGenomes-Gn:Rv0151c,EnsemblGenomes-Tr:CCP42876,InterPro:IPR000084,InterPro:IPR013228,InterPro:IPR029058,UniProtKB/TrEMBL:Q79G06,NCBI_GP:CCP42876.1;Name=CCP42876.1;Note=Rv0151c%2C (MTCI5.25c)%2C len: 588 aa. PE1%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C with N-terminal region similar to others e.g. MTV032_2 PE_PGRS family from Mycobacterium tuberculosis (468 aa)%2C FASTA scores: opt: 1125%2C E(): 0%2C (46.3%25 identity in 456 aa overlap)%3B MTCY493_24 from Mycobacterium tuberculosis FASTA score: (42.5%25 identity in 558 aa overlap). Also similar to upstream ORF MTCI5.26c FASTA score: (54.7%25 identity in 464 aa overlap). Also shows similarity to C-terminal part of some PPE family proteins e.g. MTV049_21 from Mycobacterium tuberculosis FASTA score: (41.5%25 identity in 591 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE1;locus_tag=Rv0151c;product=PE family protein PE1;protein_id=CCP42876.1;transl_table=11
AL123456.3	EMBL	gene	179319	180896	.	-	.	ID=gene-Rv0152c;Name=PE2;gbkey=Gene;gene=PE2;gene_biotype=protein_coding;locus_tag=Rv0152c
AL123456.3	EMBL	CDS	179319	180896	.	-	0	ID=cds-CCP42877.1;Parent=gene-Rv0152c;Dbxref=EnsemblGenomes-Gn:Rv0152c,EnsemblGenomes-Tr:CCP42877,GOA:Q79G05,InterPro:IPR013228,UniProtKB/TrEMBL:Q79G05,NCBI_GP:CCP42877.1;Name=CCP42877.1;Note=Rv0152c%2C (MTCI5.26c)%2C len: 525 aa. PE2%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C similar to ORF downstream Z92770|MTCI5_25 (588 aa)%2CFASTA scores: opt: 1492%2C E(): 0%2C (54.7%25 identity in 464 aa overlap)%3B and to many other PE family type members. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE2;locus_tag=Rv0152c;product=PE family protein PE2;protein_id=CCP42877.1;transl_table=11
AL123456.3	EMBL	gene	181155	181985	.	-	.	ID=gene-Rv0153c;Name=ptbB;gbkey=Gene;gene=ptbB;gene_biotype=protein_coding;gene_synonym=MPtpB;locus_tag=Rv0153c
AL123456.3	EMBL	CDS	181155	181985	.	-	0	ID=cds-CCP42878.1;Parent=gene-Rv0153c;Dbxref=EnsemblGenomes-Gn:Rv0153c,EnsemblGenomes-Tr:CCP42878,GOA:I6WXK4,InterPro:IPR000387,InterPro:IPR025163,InterPro:IPR026893,InterPro:IPR029021,UniProtKB/TrEMBL:I6WXK4,NCBI_GP:CCP42878.1;Name=CCP42878.1;Note=Rv0153c%2C (MTCI5.27c)%2C len: 276 aa. PtbB (alternate gene name: MPtpB)%2C protein-tyrosine-phosphatase (see citation below)%2C showing some similarity to several protein-tyrosine phosphatases%2C polyketide synthase and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH protein-tyrosine-phosphatase precursor from Nostoc commune (294 aa)%2C FASTA scores: opt: 150%2C E(): 0.0096%2C (26.8%25 identity in 269 aa overlap)%3B etc. Supposedly a secreted protein. Potent and selective inhibitor is an isoxazole compound (See Seollner et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ptbB;locus_tag=Rv0153c;product=Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase);protein_id=CCP42878.1;transl_table=11
AL123456.3	EMBL	gene	181987	183198	.	-	.	ID=gene-Rv0154c;Name=fadE2;gbkey=Gene;gene=fadE2;gene_biotype=protein_coding;locus_tag=Rv0154c
AL123456.3	EMBL	CDS	181987	183198	.	-	0	ID=cds-CCP42879.1;Parent=gene-Rv0154c;Dbxref=EnsemblGenomes-Gn:Rv0154c,EnsemblGenomes-Tr:CCP42879,GOA:P96831,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P96831,NCBI_GP:CCP42879.1;Name=CCP42879.1;Note=Rv0154c%2C (MTCI5.28c)%2C len: 403 aa. Probable fadE2%2Cacyl-CoA dehydrogenase%2C similar to many e.g. C-terminal region of O01590 acyl-CoA dehydrogenase (974 aa)%2C FASTA scores: opt: 1150%2C E(): 0%2C (50.0%25 identity in 402 aa overlap)%3B ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain) (383 aa)%2C FASTA score: (35.0%25 identity in 306 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE2;locus_tag=Rv0154c;product=Probable acyl-CoA dehydrogenase FadE2;protein_id=CCP42879.1;transl_table=11
AL123456.3	EMBL	gene	183622	184722	.	+	.	ID=gene-Rv0155;Name=pntAa;gbkey=Gene;gene=pntAa;gene_biotype=protein_coding;locus_tag=Rv0155
AL123456.3	EMBL	CDS	183622	184722	.	+	0	ID=cds-CCP42880.1;Parent=gene-Rv0155;Dbxref=EnsemblGenomes-Gn:Rv0155,EnsemblGenomes-Tr:CCP42880,GOA:P96832,InterPro:IPR007698,InterPro:IPR007886,InterPro:IPR026255,UniProtKB/TrEMBL:P96832,NCBI_GP:CCP42880.1;Name=CCP42880.1;Note=Rv0155%2C (MTCI5.29)%2C len: 366 aa. Probable pntAa%2Cfirst part of NAD(P) transhydrogenase subunit alpha%2Csimilar to N-terminus of others e.g. PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase subunit alpha from Escherichia coli strain K12 (510 aa)%2CFASTA scores: opt: 921%2C E(): 0%2C (42.1%25 identity in 361 aa overlap)%3B proton-translocating nicotinamide nucleotide transhydrogenase subunit PNTAA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pntAa;locus_tag=Rv0155;product=Probable NAD(P) transhydrogenase (subunit alpha) PntAa [first part%3B catalytic part] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha);protein_id=CCP42880.1;transl_table=11
AL123456.3	EMBL	gene	184723	185055	.	+	.	ID=gene-Rv0156;Name=pntAb;gbkey=Gene;gene=pntAb;gene_biotype=protein_coding;locus_tag=Rv0156
AL123456.3	EMBL	CDS	184723	185055	.	+	0	ID=cds-CCP42881.1;Parent=gene-Rv0156;Dbxref=EnsemblGenomes-Gn:Rv0156,EnsemblGenomes-Tr:CCP42881,GOA:P96833,InterPro:IPR024605,UniProtKB/TrEMBL:P96833,NCBI_GP:CCP42881.1;Name=CCP42881.1;Note=Rv0156%2C (MTCI5.30)%2C len: 110 aa. Probable pntAb%2Csecond part of NAD(P) transhydrogenase subunit alpha%2Cintegral membrane protein%2C similar to C-terminus of others e.g. Q59764 nicotinamide nucleotide transhydrogenase subunit PNTAB (139 aa)%2C FASTA scores: opt: 247%2C E(): 1.9e-11%2C (45.5%25 identity in 88 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pntAb;locus_tag=Rv0156;product=Probable NAD(P) transhydrogenase (subunit alpha) PntAb [second part%3B integral membrane protein] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha);protein_id=CCP42881.1;transl_table=11
AL123456.3	EMBL	gene	185052	186479	.	+	.	ID=gene-Rv0157;Name=pntB;gbkey=Gene;gene=pntB;gene_biotype=protein_coding;locus_tag=Rv0157
AL123456.3	EMBL	CDS	185052	186479	.	+	0	ID=cds-CCP42882.1;Parent=gene-Rv0157;Dbxref=EnsemblGenomes-Gn:Rv0157,EnsemblGenomes-Tr:CCP42882,GOA:P96834,InterPro:IPR012136,InterPro:IPR029035,UniProtKB/TrEMBL:P96834,NCBI_GP:CCP42882.1;Name=CCP42882.1;Note=Rv0157%2C (MTCI5.31)%2C len: 475 aa. Probable pntB%2Cpyridine nucleotide transhydrogenase (nicotinamide nucleotide transhydrogenase) subunit beta%2C integral membrane protein%2C similar to others e.g. Q59763 proton-translocating nicotinamide nucleotide transhydrogenase subunit beta from hodospirillum rubrum (464 aa)%2C FASTA scores: opt: 1344%2C E(): 0%2C (46.4%25 identity in 472 aa overlap)%3B P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P) transhydrogenase subunit beta from Escherichia coli strains K12 and O157:H7 (462 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pntB;locus_tag=Rv0157;product=Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta);protein_id=CCP42882.1;transl_table=11
AL123456.3	EMBL	gene	186495	186623	.	-	.	ID=gene-Rv0157A;Name=Rv0157A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0157A
AL123456.3	EMBL	CDS	186495	186623	.	-	0	ID=cds-CCP42883.1;Parent=gene-Rv0157A;Dbxref=EnsemblGenomes-Gn:Rv0157A,EnsemblGenomes-Tr:CCP42883,UniProtKB/TrEMBL:I6WXK8,NCBI_GP:CCP42883.1;Name=CCP42883.1;Note=Rv0157A%2C len: 42 aa. Conserved protein%2C showing similarity to C-terminal part (aa 186-220) of O53976|Rv1975|MTV051.13 conserved hypothetical protein from Mycobacterium tuberculosis (221 aa)%2C FASTA scores: opt: 173%2C E(): 3e-06%2C (62.5%25 identity in 40 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0157A;product=Conserved protein;protein_id=CCP42883.1;transl_table=11
AL123456.3	EMBL	gene	186785	187429	.	+	.	ID=gene-Rv0158;Name=Rv0158;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0158
AL123456.3	EMBL	CDS	186785	187429	.	+	0	ID=cds-CCP42884.1;Parent=gene-Rv0158;Dbxref=EnsemblGenomes-Gn:Rv0158,EnsemblGenomes-Tr:CCP42884,GOA:O53641,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR013571,InterPro:IPR015893,UniProtKB/TrEMBL:O53641,NCBI_GP:CCP42884.1;Name=CCP42884.1;Note=Rv0158%2C (MTV032.01)%2C len: 214 aa. Probable transcriptional regulator%2C possibly TetR family%2C showing weak similarity to various transcriptional activators and repressors e.g. P32398|YIXD_BACSU|YHGD hypothetical transcriptional regulatory protein from Bacillus subtilis (191 aa)%2C FASTA scores: opt:172%2C E(): 2.4e-05%2C (23.0%25 identity in 191 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1296%2C +3.60 SD). Could belong to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0158;product=Probable transcriptional regulatory protein (possibly TetR-family);protein_id=CCP42884.1;transl_table=11
AL123456.3	EMBL	gene	187433	188839	.	-	.	ID=gene-Rv0159c;Name=PE3;gbkey=Gene;gene=PE3;gene_biotype=protein_coding;locus_tag=Rv0159c
AL123456.3	EMBL	CDS	187433	188839	.	-	0	ID=cds-CCP42885.1;Parent=gene-Rv0159c;Dbxref=EnsemblGenomes-Gn:Rv0159c,EnsemblGenomes-Tr:CCP42885,InterPro:IPR000084,InterPro:IPR013228,InterPro:IPR029058,UniProtKB/TrEMBL:Q79G04,NCBI_GP:CCP42885.1;Name=CCP42885.1;Note=Rv0159c%2C (MTV032.02c)%2C len: 468 aa. PE3%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C similar to many other PE proteins e.g. O06828 from Mycobacterium tuberculosis (528 aa)%2C FASTA scores: opt: 1163%2C E(): 0%2C (45.8%25 identity in 467 aa overlap). Also highly similar to upstream MTV032_3%2C and to MTCI5_25%2CMTCI5_26%2C MTV049_ 21%2C MTCY1A10_26%2C etc.;gbkey=CDS;gene=PE3;locus_tag=Rv0159c;product=PE family protein PE3;protein_id=CCP42885.1;transl_table=11
AL123456.3	EMBL	gene	188931	190439	.	-	.	ID=gene-Rv0160c;Name=PE4;gbkey=Gene;gene=PE4;gene_biotype=protein_coding;locus_tag=Rv0160c
AL123456.3	EMBL	CDS	188931	190439	.	-	0	ID=cds-CCP42886.1;Parent=gene-Rv0160c;Dbxref=EnsemblGenomes-Gn:Rv0160c,EnsemblGenomes-Tr:CCP42886,InterPro:IPR000084,InterPro:IPR013228,InterPro:IPR029058,UniProtKB/TrEMBL:L7N661,NCBI_GP:CCP42886.1;Name=CCP42886.1;Note=Rv0160c%2C (MTV032.03c)%2C len: 502 aa. PE4%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C similar to many other PE proteins e.g. Z92770|MTCI5_26c from Mycobacterium tuberculosis (525 aa)%2CFASTA scores: opt: 816%2C E(): 0%2C (41.4%25 identity in 367 aa overlap)%3B C-terminal region of O06801|RV1768|MTCY28.34 from Mycobacterium tuberculosis (618 aa)%2C FASTA scores: opt: 417%2C E(): 6.7e-18%2C (53.5%25 identity in 142 aa overlap). Also highly similar to downstream ORF MTV032_2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE4;locus_tag=Rv0160c;product=PE family protein PE4;protein_id=CCP42886.1;transl_table=11
AL123456.3	EMBL	gene	190607	191956	.	+	.	ID=gene-Rv0161;Name=Rv0161;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0161
AL123456.3	EMBL	CDS	190607	191956	.	+	0	ID=cds-CCP42887.1;Parent=gene-Rv0161;Dbxref=EnsemblGenomes-Gn:Rv0161,EnsemblGenomes-Tr:CCP42887,GOA:O07406,InterPro:IPR004113,InterPro:IPR006094,InterPro:IPR016164,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,InterPro:IPR016171,UniProtKB/TrEMBL:O07406,NCBI_GP:CCP42887.1;Name=CCP42887.1;Note=Rv0161%2C (MTCI28.01%2C MTV032.04)%2C len: 449 aa. Possible oxidoreductase%2C similar to hypothetical proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 actin interacting protein 2 (530 aa)%2C FASTA scores: opt: 356%2C E (): 0%2C (33.3%25 identity in 357 aa overlap)%3B DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome) (587 aa)%2C FASTA scores: opt: 311%2C E(): 2.5e-20%2C (27.9%25 identity in 366 aa overlap). Also similar to other Mycobacteria proteins e.g. MTCY339.30c from Mycobacterium tuberculosis FASTA score: (29.4%25 identity in 357 aa overlap)%3B MLCL622.30c from Mycobacterium tuberculosis (449 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0161;product=Possible oxidoreductase;protein_id=CCP42887.1;transl_table=11
AL123456.3	EMBL	gene	191984	193135	.	-	.	ID=gene-Rv0162c;Name=adhE1;gbkey=Gene;gene=adhE1;gene_biotype=protein_coding;locus_tag=Rv0162c
AL123456.3	EMBL	CDS	191984	193135	.	-	0	ID=cds-CCP42888.1;Parent=gene-Rv0162c;Dbxref=EnsemblGenomes-Gn:Rv0162c,EnsemblGenomes-Tr:CCP42888,GOA:L7N6B3,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,UniProtKB/TrEMBL:L7N6B3,NCBI_GP:CCP42888.1;Name=CCP42888.1;Note=Rv0162c%2C (MTCI28.02c)%2C len: 383 aa. Probable adhE1%2Czinc-type alcohol dehydrogenase%2C similar to others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha chain (374 aa)%2C FASTA scores: opt: 619%2C E(): 0%2C (34.7%25 identity in 363 aa overlap). Also similar to other alcohol dehydrogenases from Mycobacterium tuberculosis e.g. MTCY369.06c FASTA score: (34.0%25 identity in 365 aa overlap)%2C MTV022_9 FASTA score: (35.0%25 identity in 371 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Belongs to the zinc-containing alcohol dehydrogenase family%2Cclass-I subfamily. Cofactor: zinc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adhE1;inference=protein motif:PROSITE:PS00059;locus_tag=Rv0162c;product=Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1;protein_id=CCP42888.1;transl_table=11
AL123456.3	EMBL	gene	193117	193572	.	+	.	ID=gene-Rv0163;Name=Rv0163;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0163
AL123456.3	EMBL	CDS	193117	193572	.	+	0	ID=cds-CCP42889.1;Parent=gene-Rv0163;Dbxref=EnsemblGenomes-Gn:Rv0163,EnsemblGenomes-Tr:CCP42889,GOA:O07408,InterPro:IPR006683,InterPro:IPR029069,UniProtKB/TrEMBL:O07408,NCBI_GP:CCP42889.1;Name=CCP42889.1;Note=Rv0163%2C (MTCI28.03)%2C len: 151 aa. Conserved protein%2Csimilar to others e.g. Q44017 hypothetical 16.6 KDA protein in GBD 5'region (ORF6)from Alcaligenes eutrophus (145 aa)%2CFASTA scores: opt: 155%2C E(): 0.0002%2C (26.6%25 identity in 139 aa overlap). Also weak similarity with MTV008.31c|Rv2475c|B70867 from Mycobacterium tuberculosis (138 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0163;product=Conserved protein;protein_id=CCP42889.1;transl_table=11
AL123456.3	EMBL	gene	193626	194111	.	+	.	ID=gene-Rv0164;Name=TB18.5;gbkey=Gene;gene=TB18.5;gene_biotype=protein_coding;locus_tag=Rv0164
AL123456.3	EMBL	CDS	193626	194111	.	+	0	ID=cds-CCP42890.1;Parent=gene-Rv0164;Dbxref=EnsemblGenomes-Gn:Rv0164,EnsemblGenomes-Tr:CCP42890,InterPro:IPR005031,InterPro:IPR023393,UniProtKB/TrEMBL:L7N657,NCBI_GP:CCP42890.1;Name=CCP42890.1;Note=Rv0164%2C (MTCI28.04)%2C len: 161 aa. TB18.5%2C conserved protein%2C equivalent to CAB08818.1|Z95398 hypothetical protein from Mycobacterium leprae (156 aa) FASTA scores: opt: 762%2C E(): 0%2C (76.3%25 identity in 152 aa overlap). Some similarity to Rv2185c%2C Rv0854%2C Rv0857 from Mycobacterium tuberculosis. Alternative start codon has been suggested. 3' part corrected since first submission (-24 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB18.5;locus_tag=Rv0164;product=Conserved protein TB18.5;protein_id=CCP42890.1;transl_table=11
AL123456.3	EMBL	gene	194144	194815	.	-	.	ID=gene-Rv0165c;Name=mce1R;gbkey=Gene;gene=mce1R;gene_biotype=protein_coding;locus_tag=Rv0165c
AL123456.3	EMBL	CDS	194144	194815	.	-	0	ID=cds-CCP42891.1;Parent=gene-Rv0165c;Dbxref=EnsemblGenomes-Gn:Rv0165c,EnsemblGenomes-Tr:CCP42891,GOA:Q79G00,InterPro:IPR000524,InterPro:IPR008920,InterPro:IPR011711,InterPro:IPR011991,UniProtKB/TrEMBL:Q79G00,NCBI_GP:CCP42891.1;Name=CCP42891.1;Note=Rv0165c%2C (MTCI28.05c)%2C len: 223 aa. Probable mce1R%2Ctranscriptional regulator%2C GntR family (See Casali et al.%2C2006)%2C showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa)%2C FASTA scores: opt: 154%2C E(): 0.00058%2C (32.0%25 identity in 125 aa overlap)%3B P46833|GNTR_BACLI gluconate operon transcriptional repressor from Bacillus licheniformis (243 aa)%3B GNTR_BACSU gluconate operon repressor from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. Seems to belong to the GntR family of transcriptional regulators. Start changed since first submission (-41 aa).;gbkey=CDS;gene=mce1R;locus_tag=Rv0165c;product=Probable transcriptional regulatory protein Mce1R (probably GntR-family);protein_id=CCP42891.1;transl_table=11
AL123456.3	EMBL	gene	194993	196657	.	+	.	ID=gene-Rv0166;Name=fadD5;gbkey=Gene;gene=fadD5;gene_biotype=protein_coding;locus_tag=Rv0166
AL123456.3	EMBL	CDS	194993	196657	.	+	0	ID=cds-CCP42892.1;Parent=gene-Rv0166;Dbxref=EnsemblGenomes-Gn:Rv0166,EnsemblGenomes-Tr:CCP42892,GOA:O07411,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O07411,NCBI_GP:CCP42892.1;Name=CCP42892.1;Note=Rv0166%2C (MTCI28.06)%2C len: 554 aa. Probable fadD5%2Cfatty-acid-CoA synthetase%2C similar to many eg LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa)%2C FASTA scores: opt: 612%2C E(): 0%2C (29.4%25 identity in 534 aa overlap). Also similar to many other fatty-acid-CoA ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c FASTA score: (35.3%25 identity in 487 aa overlap)%2C MTV013_10%2CMTY25D10_30%2C etc. Contains PS00455 putative AMP-binding domain signature.;gbkey=CDS;gene=fadD5;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0166;product=Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP42892.1;transl_table=11
AL123456.3	EMBL	gene	196861	197658	.	+	.	ID=gene-Rv0167;Name=yrbE1A;gbkey=Gene;gene=yrbE1A;gene_biotype=protein_coding;locus_tag=Rv0167
AL123456.3	EMBL	CDS	196861	197658	.	+	0	ID=cds-CCP42893.1;Parent=gene-Rv0167;Dbxref=EnsemblGenomes-Gn:Rv0167,EnsemblGenomes-Tr:CCP42893,GOA:O07412,InterPro:IPR003453,UniProtKB/TrEMBL:O07412,NCBI_GP:CCP42893.1;Name=CCP42893.1;Note=Rv0167%2C (MTCI28.07)%2C len: 265 aa. YrbE1A%2C unknown integral membrane protein%2C part of mce1 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa)%3B O53965|Rv1964|MTV051.02|yrbE3A (265 aa)%3B etc. Also highly similar or similar to conserved hypothetical integral membrane proteins of yrbEA type%2C e.g. NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa)%3B P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa)%2C FASTA scores: opt: 328%2CE(): 1.8e-15%2C (26.6%25 identity in 244 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yrbE1A;locus_tag=Rv0167;product=Conserved integral membrane protein YrbE1A;protein_id=CCP42893.1;transl_table=11
AL123456.3	EMBL	gene	197660	198529	.	+	.	ID=gene-Rv0168;Name=yrbE1B;gbkey=Gene;gene=yrbE1B;gene_biotype=protein_coding;locus_tag=Rv0168
AL123456.3	EMBL	CDS	197660	198529	.	+	0	ID=cds-CCP42894.1;Parent=gene-Rv0168;Dbxref=EnsemblGenomes-Gn:Rv0168,EnsemblGenomes-Tr:CCP42894,InterPro:IPR003453,UniProtKB/TrEMBL:L0T2Q9,NCBI_GP:CCP42894.1;Name=CCP42894.1;Note=Rv0168%2C (MTCI28.08)%2C len: 289 aa. YrbE1B%2C unknown integral membrane protein%2C part of mce1 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa)%3B O53966|Rv1965|MTV051.03|yrbE3B (271 aa)%3B etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type%2C e.g. NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa)%3B P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa)%2C FASTA scores: opt: 223%2CE(): 7.6e-07%2C (23.7%25 identity in 257 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yrbE1B;locus_tag=Rv0168;product=Conserved integral membrane protein YrbE1B;protein_id=CCP42894.1;transl_table=11
AL123456.3	EMBL	gene	198534	199898	.	+	.	ID=gene-Rv0169;Name=mce1A;gbkey=Gene;gene=mce1A;gene_biotype=protein_coding;gene_synonym=mce1;locus_tag=Rv0169
AL123456.3	EMBL	CDS	198534	199898	.	+	0	ID=cds-CCP42895.1;Parent=gene-Rv0169;Dbxref=EnsemblGenomes-Gn:Rv0169,EnsemblGenomes-Tr:CCP42895,GOA:Q79FZ9,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR024516,UniProtKB/TrEMBL:Q79FZ9,NCBI_GP:CCP42895.1;Name=CCP42895.1;Note=Rv0169%2C (MTCI28.09)%2C len: 454 aa. Mce1A%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa)%3B O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa)%3B etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa)%3B NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa)%3B AAA92845.1|U26018 mce gene product from Mycobacterium avium (88 aa) (similarity on C-terminus)%3B CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa)%3B etc. Note that equivalent%2C but longer 22 aa%2C to P72013|CAA50257.1|X70901 Mcep protein from Mycobacterium tuberculosis (432 aa). Contains a very hydrophobic region around residues 20-35. Note that previously known as mce1. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce1A;locus_tag=Rv0169;product=Mce-family protein Mce1A;protein_id=CCP42895.1;transl_table=11
AL123456.3	EMBL	gene	199895	200935	.	+	.	ID=gene-Rv0170;Name=mce1B;gbkey=Gene;gene=mce1B;gene_biotype=protein_coding;gene_synonym=mceD;locus_tag=Rv0170
AL123456.3	EMBL	CDS	199895	200935	.	+	0	ID=cds-CCP42896.1;Parent=gene-Rv0170;Dbxref=EnsemblGenomes-Gn:Rv0170,EnsemblGenomes-Tr:CCP42896,GOA:O07414,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR024516,UniProtKB/TrEMBL:O07414,NCBI_GP:CCP42896.1;Name=CCP42896.1;Note=Rv0170%2C (MTCI28.10)%2C len: 346 aa. Mce1B (alternate gene name: mceD)%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2Chighly similar to Mycobacterium tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa)%3B O53968|Rv1967|MTV051.05|mce3B (342 aa)%3B etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa)%3B CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa)%3B etc. Contains hydrophobic region in N-terminal 30 residues. In Escherichia coli%2CN-terminal part is functional and directs export of a leaderless beta-lactamase into the periplasm (see Chubb et al.%2C 1998). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce1B;locus_tag=Rv0170;product=Mce-family protein Mce1B;protein_id=CCP42896.1;transl_table=11
AL123456.3	EMBL	gene	200932	202479	.	+	.	ID=gene-Rv0171;Name=mce1C;gbkey=Gene;gene=mce1C;gene_biotype=protein_coding;locus_tag=Rv0171
AL123456.3	EMBL	CDS	200932	202479	.	+	0	ID=cds-CCP42897.1;Parent=gene-Rv0171;Dbxref=EnsemblGenomes-Gn:Rv0171,EnsemblGenomes-Tr:CCP42897,GOA:O07415,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR008360,UniProtKB/TrEMBL:O07415,NCBI_GP:CCP42897.1;Name=CCP42897.1;Note=Rv0171%2C (MTCI28.11)%2C len: 515 aa. Mce1C%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 aa)%3B O53969|Rv1968|MTV051.06|mce3C (410 aa)%3B etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa)%3B CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa)%3B etc. Weakly similar to downstream ORF Rv0172|MTCI28.12|mce1D (530 aa)%2C FASTA score: (24.6%25 identity in 552 aa overlap). Contains possible signal sequence and highly proline-rich C-terminus. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce1C;locus_tag=Rv0171;product=Mce-family protein Mce1C;protein_id=CCP42897.1;transl_table=11
AL123456.3	EMBL	gene	202476	204068	.	+	.	ID=gene-Rv0172;Name=mce1D;gbkey=Gene;gene=mce1D;gene_biotype=protein_coding;locus_tag=Rv0172
AL123456.3	EMBL	CDS	202476	204068	.	+	0	ID=cds-CCP42898.1;Parent=gene-Rv0172;Dbxref=EnsemblGenomes-Gn:Rv0172,EnsemblGenomes-Tr:CCP42898,GOA:O07416,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O07416,NCBI_GP:CCP42898.1;Name=CCP42898.1;Note=Rv0172%2C (MTCI28.12)%2C len: 530 aa. Mce1D%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa)%3B O53970|Rv1969|MTV051.07|mce3D (423 aa)%3B etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa)%3B CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa)%3B etc. Hydrophobic region at N-terminus. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce1D;locus_tag=Rv0172;product=Mce-family protein Mce1D;protein_id=CCP42898.1;transl_table=11
AL123456.3	EMBL	gene	204065	205237	.	+	.	ID=gene-Rv0173;Name=lprK;gbkey=Gene;gene=lprK;gene_biotype=protein_coding;gene_synonym=mce1E;locus_tag=Rv0173
AL123456.3	EMBL	CDS	204065	205237	.	+	0	ID=cds-CCP42899.1;Parent=gene-Rv0173;Dbxref=EnsemblGenomes-Gn:Rv0173,EnsemblGenomes-Tr:CCP42899,GOA:O07417,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O07417,NCBI_GP:CCP42899.1;Name=CCP42899.1;Note=Rv0173%2C (MTCI28.13)%2C len: 390 aa. Possible lprK (alternate gene name: mce1E)%2C lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa)%3B O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa)%3B etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa)%3B CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa)%3B etc. Contains PS00013 prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprK;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0173;product=Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E);protein_id=CCP42899.1;transl_table=11
AL123456.3	EMBL	gene	205231	206778	.	+	.	ID=gene-Rv0174;Name=mce1F;gbkey=Gene;gene=mce1F;gene_biotype=protein_coding;locus_tag=Rv0174
AL123456.3	EMBL	CDS	205231	206778	.	+	0	ID=cds-CCP42900.1;Parent=gene-Rv0174;Dbxref=EnsemblGenomes-Gn:Rv0174,EnsemblGenomes-Tr:CCP42900,GOA:L0T2W6,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:L0T2W6,NCBI_GP:CCP42900.1;Name=CCP42900.1;Note=Rv0174%2C (MTCI28.14)%2C len: 515 aa. Mce1F%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C similar to Mycobacterium tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa)%3B O53972|Rv1971|MTV051.09|mce3F (437 aa)%3B etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa)%3B AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus)%3B CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa)%3B etc. Has hydrophobic stretch%2C possibly a signal peptide at the N-terminus. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce1F;locus_tag=Rv0174;product=Mce-family protein Mce1F;protein_id=CCP42900.1;transl_table=11
AL123456.3	EMBL	repeat_region	206812	206850	.	+	.	ID=id-AL123456.3:206812..206850;Note=39 bp direct repeat 1%2CAGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG;gbkey=repeat_region
AL123456.3	EMBL	gene	206814	207455	.	+	.	ID=gene-Rv0175;Name=Rv0175;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0175
AL123456.3	EMBL	CDS	206814	207455	.	+	0	ID=cds-CCP42901.1;Parent=gene-Rv0175;Dbxref=EnsemblGenomes-Gn:Rv0175,EnsemblGenomes-Tr:CCP42901,GOA:O07419,UniProtKB/TrEMBL:O07419,NCBI_GP:CCP42901.1;Name=CCP42901.1;Note=Rv0175%2C (MTCI28.15)%2C len: 213 aa. Probable conserved Mce-associated membrane protein%2C equivalent%2C but longer in N-terminus%2C to CAC32127.1|AL583926 possible membrane protein from Mycobacterium leprae (182 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c%2C Rv0177%2C Rv1973%2C etc. Contains two 12 residue direct repeats at N-terminus. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0175;product=Probable conserved Mce associated membrane protein;protein_id=CCP42901.1;transl_table=11
AL123456.3	EMBL	repeat_region	206869	206907	.	+	.	ID=id-Rv0175;Note=39 bp direct repeat 2%2CAGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG;gbkey=repeat_region;locus_tag=Rv0175
AL123456.3	EMBL	gene	207452	208420	.	+	.	ID=gene-Rv0176;Name=Rv0176;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0176
AL123456.3	EMBL	CDS	207452	208420	.	+	0	ID=cds-CCP42902.1;Parent=gene-Rv0176;Dbxref=EnsemblGenomes-Gn:Rv0176,EnsemblGenomes-Tr:CCP42902,GOA:O07420,InterPro:IPR010432,UniProtKB/TrEMBL:O07420,NCBI_GP:CCP42902.1;Name=CCP42902.1;Note=Rv0176%2C (MTCI28.16)%2C len: 322 aa. Probable conserved Mce-associated transmembrane protein. Contains short region of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 kDa antigen) from Mycobacterium leprae (249 aa) (outside the proline-rich region)%2C FASTA scores: opt: 165%2C E(): 2.9e-05%2C (40.0%25 identity in 65 aa overlap). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c%2C Rv0177%2C Rv3493c%2C etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0176;product=Probable conserved Mce associated transmembrane protein;protein_id=CCP42902.1;transl_table=11
AL123456.3	EMBL	gene	208417	208971	.	+	.	ID=gene-Rv0177;Name=Rv0177;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0177
AL123456.3	EMBL	CDS	208417	208971	.	+	0	ID=cds-CCP42903.1;Parent=gene-Rv0177;Dbxref=EnsemblGenomes-Gn:Rv0177,EnsemblGenomes-Tr:CCP42903,GOA:O07421,UniProtKB/TrEMBL:O07421,NCBI_GP:CCP42903.1;Name=CCP42903.1;Note=Rv0177%2C (MTCI28.17)%2C len: 184 aa. Probable conserved Mce-associated protein%2C equivalent to CAC32129.1|AL583926 conserved membrane protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c%2C Rv1973%2C Rv3493c%2Cetc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0177;product=Probable conserved Mce associated protein;protein_id=CCP42903.1;transl_table=11
AL123456.3	EMBL	gene	208938	209672	.	+	.	ID=gene-Rv0178;Name=Rv0178;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0178
AL123456.3	EMBL	CDS	208938	209672	.	+	0	ID=cds-CCP42904.1;Parent=gene-Rv0178;Dbxref=EnsemblGenomes-Gn:Rv0178,EnsemblGenomes-Tr:CCP42904,GOA:O07422,UniProtKB/TrEMBL:O07422,NCBI_GP:CCP42904.1;Name=CCP42904.1;Note=Rv0178%2C (MTCI28.18)%2C len: 244 aa. Probable conserved Mce-associated membrane protein%2C highly similar in C-terminus to CAC32130.1|AL583926 putative secreted protein from Mycobacterium leprae (184 aa). Also similar to mce-associated proteins from Mycobacterium tuberculosis e.g. Rv1363c%2C Rv0177%2C Rv1973%2C etc. Note that there is a 10 aa overlap with the upstream ORF. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0178;product=Probable conserved Mce associated membrane protein;protein_id=CCP42904.1;transl_table=11
AL123456.3	EMBL	gene	209703	210812	.	-	.	ID=gene-Rv0179c;Name=lprO;gbkey=Gene;gene=lprO;gene_biotype=protein_coding;locus_tag=Rv0179c
AL123456.3	EMBL	CDS	209703	210812	.	-	0	ID=cds-CCP42905.1;Parent=gene-Rv0179c;Dbxref=EnsemblGenomes-Gn:Rv0179c,EnsemblGenomes-Tr:CCP42905,GOA:O07423,InterPro:IPR018711,UniProtKB/TrEMBL:O07423,NCBI_GP:CCP42905.1;Name=CCP42905.1;Note=Rv0179c%2C (MTCI28.19c)%2C len: 369 aa. Possible lprO%2Clipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lprO;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0179c;product=Possible lipoprotein LprO;protein_id=CCP42905.1;transl_table=11
AL123456.3	EMBL	gene	210892	212250	.	-	.	ID=gene-Rv0180c;Name=Rv0180c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0180c
AL123456.3	EMBL	CDS	210892	212250	.	-	0	ID=cds-CCP42906.1;Parent=gene-Rv0180c;Dbxref=EnsemblGenomes-Gn:Rv0180c,EnsemblGenomes-Tr:CCP42906,GOA:O07424,InterPro:IPR022703,UniProtKB/TrEMBL:O07424,NCBI_GP:CCP42906.1;Name=CCP42906.1;Note=Rv0180c%2C (MTCI28.20c)%2C len: 452 aa. Probable conserved transmembrane protein%2C equivalent to CAC32132.1|AL583926 probable conserved membrane protein from Mycobacterium leprae (465 aa). Shows some similarity with others membrane proteins e.g. AL096849|SCI11_29 from Streptomyces coelicolor (354 aa)%2C FASTA scores: opt: 190%2CE(): 0.00067%2C (25.9%25 identity in 409 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0180c;product=Probable conserved transmembrane protein;protein_id=CCP42906.1;transl_table=11
AL123456.3	EMBL	gene	212277	213011	.	-	.	ID=gene-Rv0181c;Name=Rv0181c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0181c
AL123456.3	EMBL	CDS	212277	213011	.	-	0	ID=cds-CCP42907.1;Parent=gene-Rv0181c;Dbxref=EnsemblGenomes-Gn:Rv0181c,EnsemblGenomes-Tr:CCP42907,GOA:P9WI85,InterPro:IPR003829,InterPro:IPR011051,InterPro:IPR012093,InterPro:IPR014710,NCBI_GP:CCP42907.1;Name=CCP42907.1;Note=Rv0181c%2C (MTCI28.21c)%2C len: 244 aa. Conserved hypothetical protein%2C highly similar to other hypothetical proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd protein from Escherichia coli (231 aa)%2C FASTA scores: opt: 479%2C E(): 1.2e-29%2C (37.3%25 identity in 233 aa overlap)%3B P73623|SLL1773 hypothetical 25.7 kDa protein from Synechocystis sp. strain PCC 6803 (232 aa)%2C FASTA score: (39.1%25 identity in 233 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0181c;product=Conserved hypothetical protein;protein_id=CCP42907.1;transl_table=11
AL123456.3	EMBL	gene	213028	214140	.	-	.	ID=gene-Rv0182c;Name=sigG;gbkey=Gene;gene=sigG;gene_biotype=protein_coding;locus_tag=Rv0182c
AL123456.3	EMBL	CDS	213028	214140	.	-	0	ID=cds-CCP42908.1;Parent=gene-Rv0182c;Dbxref=EnsemblGenomes-Gn:Rv0182c,EnsemblGenomes-Tr:CCP42908,GOA:P9WGG5,InterPro:IPR000838,InterPro:IPR007627,InterPro:IPR009959,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,InterPro:IPR014305,NCBI_GP:CCP42908.1;Name=CCP42908.1;Note=Rv0182c%2C (MTCI28.22c)%2C len: 370 aa (start site uncertain%3B first of several possibles was chosen%2C but note that this overlaps the upstream ORF). Probable sigG%2Calternative RNA polymerase sigma subunit (see citations below)%2C similar to many e.g. Q45585|SIGW_BACSU RNA polymerase sigma factor from Bacillus subtilis (187 aa). Also similar to nine other ECF sigma factors from Mycobacterium tuberculosis e.g. Rv1221%2C Rv0735%2C etc. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 205-226 (Score 1181%2C +3.21 SD). Belongs to the sigma-70 factor family%2C ECF subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigG;inference=protein motif:PROSITE:PS01063;locus_tag=Rv0182c;product=Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor);protein_id=CCP42908.1;transl_table=11
AL123456.3	EMBL	gene	214088	214927	.	+	.	ID=gene-Rv0183;Name=Rv0183;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0183
AL123456.3	EMBL	CDS	214088	214927	.	+	0	ID=cds-CCP42909.1;Parent=gene-Rv0183;Dbxref=EnsemblGenomes-Gn:Rv0183,EnsemblGenomes-Tr:CCP42909,GOA:O07427,InterPro:IPR000073,InterPro:IPR029058,UniProtKB/TrEMBL:O07427,NCBI_GP:CCP42909.1;Name=CCP42909.1;Note=Rv0183%2C (MTCI28.23)%2C len: 279 aa. Possible lysophospholipase%2C similar to several (especially eukaryotic enzymes%2C weaker with Escherichia coli)%2C e.g. U67963|HSU67963_1 Human lysophospholipase homolog from Homo sapiens (313 aa)%2C FASTA scores: opt: 569%2C E(): 2.6e-29%2C(37.1%25 identity in 259 aa overlap)%3B P07000|PLDB_ECOLI lysophospholipase L2 from Escherichia coli (165 aa)%2C FASTA scores: opt: 219%2C E(): 0.00012. Start changed based on similarity to AE001997_8 from Deinococcus radiodurans (282 aa)%2C FASTA scores: opt: 510%2C E(): 1.4e-25%2C (34.8%25 identity in 282 aa overlap). Also shows some similarity to epoxide hydrolases from Mycobacterium tuberculosis e.g. Rv1938 FASTA score: (30.7%25 identity in 114 aa overlap)%3B and O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0183;product=Possible lysophospholipase;protein_id=CCP42909.1;transl_table=11
AL123456.3	EMBL	gene	214969	215718	.	+	.	ID=gene-Rv0184;Name=Rv0184;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0184
AL123456.3	EMBL	CDS	214969	215718	.	+	0	ID=cds-CCP42910.1;Parent=gene-Rv0184;Dbxref=EnsemblGenomes-Gn:Rv0184,EnsemblGenomes-Tr:CCP42910,InterPro:IPR024498,UniProtKB/TrEMBL:O07428,NCBI_GP:CCP42910.1;Name=CCP42910.1;Note=Rv0184%2C (MTCI28.24)%2C len: 249 aa. Conserved hypothetical protein%2C equivalent to CAC32136.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (249 aa)%3B and C-terminus highly similar to CAB08793.1|Z95398 conserved hypothetical protein from Mycobacterium leprae (145 aa)%2C FASTA scores: E(): 0%2C (75.2 identity in 145 aa overlap). Also similar to 049841|SCE9_39|T36358 hypothetical protein from Streptomyces coelicolor (418 aa)%2C FASTA scores: opt: 231%2CE(): 8.1e-08%2C (30.4%25 identity in 270 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv0184;product=Conserved hypothetical protein;protein_id=CCP42910.1;transl_table=11
AL123456.3	EMBL	gene	215715	216224	.	+	.	ID=gene-Rv0185;Name=Rv0185;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0185
AL123456.3	EMBL	CDS	215715	216224	.	+	0	ID=cds-CCP42911.1;Parent=gene-Rv0185;Dbxref=EnsemblGenomes-Gn:Rv0185,EnsemblGenomes-Tr:CCP42911,InterPro:IPR027595,UniProtKB/TrEMBL:O07429,NCBI_GP:CCP42911.1;Name=CCP42911.1;Note=Rv0185%2C (MTCI28.25a)%2C len: 169 aa. Conserved hypothetical protein%2C equivalent to CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 aa)%2C FASTA scores: opt: 861%2C E(): 0%2C (76.4%25 identity in 165 aa overlap). Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv0185;product=Conserved hypothetical protein;protein_id=CCP42911.1;transl_table=11
AL123456.3	EMBL	gene	216269	218344	.	+	.	ID=gene-Rv0186;Name=bglS;gbkey=Gene;gene=bglS;gene_biotype=protein_coding;locus_tag=Rv0186
AL123456.3	EMBL	CDS	216269	218344	.	+	0	ID=cds-CCP42912.1;Parent=gene-Rv0186;Dbxref=EnsemblGenomes-Gn:Rv0186,EnsemblGenomes-Tr:CCP42912,GOA:O07430,InterPro:IPR001764,InterPro:IPR002772,InterPro:IPR017853,InterPro:IPR026891,InterPro:IPR026892,UniProtKB/TrEMBL:O07430,NCBI_GP:CCP42912.1;Name=CCP42912.1;Note=Rv0186%2C (MTCI28.25b)%2C len: 691 aa. Probable bglS%2Cbeta-glucosidase%2C highly similar to many e.g. BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium tumefaciens (818 aa)%2C FASTA scores: opt: 643%2C E(): 0%2C(32.5%25 identity in 842 aa overlap). Seems to belong to family 3 of glycosyl hydrolases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bglS;locus_tag=Rv0186;product=Probable beta-glucosidase BglS (gentiobiase) (cellobiase) (beta-D-glucoside glucohydrolase);protein_id=CCP42912.1;transl_table=11
AL123456.3	EMBL	gene	218390	218551	.	-	.	ID=gene-Rv0186A;Name=mymT;gbkey=Gene;gene=mymT;gene_biotype=protein_coding;locus_tag=Rv0186A
AL123456.3	EMBL	CDS	218390	218551	.	-	0	ID=cds-CCP42913.1;Parent=gene-Rv0186A;Dbxref=EnsemblGenomes-Gn:Rv0186A,EnsemblGenomes-Tr:CCP42913,GOA:P9WK09,NCBI_GP:CCP42913.1;Name=CCP42913.1;Note=Rv0186A%2C len: 53 aa. MymT%2C metallothionein%2Cequivalent to MAV_4993|A0QMH5 hypothetical protein from Mycobacterium avium (strain 104) (51 aa)%2C and MAP_3626c|Q73TU2 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (51 aa)%2C FASTA scores: opt: 312%2C E(): 4.6e-17%2C (81.2%25 identity in 48 aa overlap).;gbkey=CDS;gene=mymT;locus_tag=Rv0186A;product=Metallothionein%2C MymT;protein_id=CCP42913.1;transl_table=11
AL123456.3	EMBL	gene	218705	219367	.	+	.	ID=gene-Rv0187;Name=Rv0187;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0187
AL123456.3	EMBL	CDS	218705	219367	.	+	0	ID=cds-CCP42914.1;Parent=gene-Rv0187;Dbxref=EnsemblGenomes-Gn:Rv0187,EnsemblGenomes-Tr:CCP42914,GOA:O07431,InterPro:IPR002935,InterPro:IPR029063,UniProtKB/TrEMBL:O07431,NCBI_GP:CCP42914.1;Name=CCP42914.1;Note=Rv0187%2C (MTCI28.26)%2C len: 220 aa. Probable O-methyltransferase%2C similar to many e.g. AB93458.1|AL357591 putative O-methyltransferase from Streptomyces coelicolor (223 aa)%3B MDMC_STRMY|Q00719 O-methyltransferase from Streptomyces mycarofaciens (221 aa)%2C FASTA scores: opt: 327%2C E(): 2.4e-17%2C (35.9%25 identity in 192 aa overlap). Also similar to Rv1703c%2C Rv1220c from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0187;product=Probable O-methyltransferase;protein_id=CCP42914.1;transl_table=11
AL123456.3	EMBL	gene	219486	219917	.	+	.	ID=gene-Rv0188;Name=Rv0188;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0188
AL123456.3	EMBL	CDS	219486	219917	.	+	0	ID=cds-CCP42915.1;Parent=gene-Rv0188;Dbxref=EnsemblGenomes-Gn:Rv0188,EnsemblGenomes-Tr:CCP42915,GOA:O07432,InterPro:IPR005530,UniProtKB/TrEMBL:O07432,NCBI_GP:CCP42915.1;Name=CCP42915.1;Note=Rv0188%2C (MTCI28.27)%2C len: 143 aa. Probable conserved transmembrane protein%2C similar to T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable membrane protein from Streptomyces coelicolor (147 aa)%2CFASTA scores: opt: 326%2C E(): 6.5e-15%2C (36.2%25 identity in 141 aa overlap)%3B N-terminus of P80185|MTRC_METTH tetrahydromethanopterin S-methyltransferase subunit C from Methanobacterium thermoautotrophicum strain Marburg/DSM 2133 (266 aa)%2C FASTA scores: opt: 125%2C E(): 0.033%2C (31.6%25 identity in 98 aa overlap). Also similar to Rv3635 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0188;product=Probable conserved transmembrane protein;protein_id=CCP42915.1;transl_table=11
AL123456.3	EMBL	gene	219996	221723	.	-	.	ID=gene-Rv0189c;Name=ilvD;gbkey=Gene;gene=ilvD;gene_biotype=protein_coding;locus_tag=Rv0189c
AL123456.3	EMBL	CDS	219996	221723	.	-	0	ID=cds-CCP42916.1;Parent=gene-Rv0189c;Dbxref=EnsemblGenomes-Gn:Rv0189c,EnsemblGenomes-Tr:CCP42916,GOA:P9WKJ5,InterPro:IPR000581,InterPro:IPR004404,InterPro:IPR015928,InterPro:IPR020558,NCBI_GP:CCP42916.1;Name=CCP42916.1;Note=Rv0189c%2C (MTCI28.28c)%2C len: 575 aa. Probable ilvD%2Cdihydroxy-acid dehydratase%2C similar to many e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (570 aa)%2C FASTA scores: opt: 1605%2C E(): 0%2C (46.0%25 identity in 561 aa overlap). Also similar to ML2608|MLCL622.06c|O06069|ILVD_MYCLE dihydroxy-acid dehydratase from Mycobacterium leprae (564 aa). Contains PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. Belongs to the ILVD / EDD family. Cofactor: binds 1 4FE-4S cluster (potential).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvD;inference=protein motif:PROSITE:PS00886;locus_tag=Rv0189c;product=Probable dihydroxy-acid dehydratase IlvD (dad);protein_id=CCP42916.1;transl_table=11
AL123456.3	EMBL	gene	221871	222161	.	+	.	ID=gene-Rv0190;Name=Rv0190;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0190
AL123456.3	EMBL	CDS	221871	222161	.	+	0	ID=cds-CCP42917.1;Parent=gene-Rv0190;Dbxref=EnsemblGenomes-Gn:Rv0190,EnsemblGenomes-Tr:CCP42917,GOA:O07434,InterPro:IPR003735,UniProtKB/TrEMBL:O07434,NCBI_GP:CCP42917.1;Name=CCP42917.1;Note=Rv0190%2C (MTCI28.29)%2C len: 96 aa. Conserved protein%2Chighly similar to several hypothetical proteins e.g. SYCSLRA_35|Q55554|SLL0176 hypothetical 18.9 kDa protein from Synechocystis (167 aa)%2C FASTA scores: opt: 237%2C E(): 5.8e-16%2C (39.4%25 identity in 94 aa overlap). Also highly similar to Z95398|MLCL622_7|O06070 from Mycobacterium leprae (135 aa)%2C FASTA score: (82.6%25 identity in 92 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0967%2C Rv0030%2C Rv1766 (42.5%25 identity in 80 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0190;product=Conserved protein;protein_id=CCP42917.1;transl_table=11
AL123456.3	EMBL	gene	222289	223530	.	+	.	ID=gene-Rv0191;Name=Rv0191;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0191
AL123456.3	EMBL	CDS	222289	223530	.	+	0	ID=cds-CCP42918.1;Parent=gene-Rv0191;Dbxref=EnsemblGenomes-Gn:Rv0191,EnsemblGenomes-Tr:CCP42918,GOA:P9WJX7,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP42918.1;Name=CCP42918.1;Note=Rv0191%2C (MTCI28.30)%2C len: 413 aa. Probable conserved integral membrane protein%2C member of major facilitator superfamily (MFS) possibly involved in transport of drug%2Csimilar to several hypothetical proteins e.g. YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from Escherichia coli (396 aa)%2C FASTA scores: opt: 475%2C E(): 4.2e-33%2C (29.7%25 identity in 381 aa overlap)%3B and to several chloramphenicol resistance proteins e.g. CMLR_STRLI|P31141 chloramphenicol resistance protein from Streptomyces lividans (392 aa)%2C FASTA scores: opt: 394%2C E(): 6.7e-12%2C(28.2%25 identity in 383 aa overlap). Also similar to SVU09991_1 from Mycobacterium tuberculosis.;gbkey=CDS;locus_tag=Rv0191;product=Probable conserved integral membrane protein;protein_id=CCP42918.1;transl_table=11
AL123456.3	EMBL	gene	223564	224664	.	+	.	ID=gene-Rv0192;Name=Rv0192;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0192
AL123456.3	EMBL	CDS	223564	224664	.	+	0	ID=cds-CCP42919.1;Parent=gene-Rv0192;Dbxref=EnsemblGenomes-Gn:Rv0192,EnsemblGenomes-Tr:CCP42919,GOA:O07436,InterPro:IPR005490,NCBI_GP:CCP42919.1;Name=CCP42919.1;Note=Rv0192%2C (MTCI28.31)%2C len: 366 aa. Conserved hypothetical protein. Has Gly- Arg-rich region followed by highly Pro-rich repetitive region near N-terminus. Similar in C-terminus to other hypothetical proteins e.g. Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271 aa)%2C FASTA scores: opt: 375%2C E(): 3.2e-24%2C (36.1%25 identity in 255 aa overlap)%3B YV09_MYCTU|Q11149|cY20G9.09 hypothetical 47.9 kDa protein from Mycobacterium tuberculosis (451 aa)%2C FASTA scores: opt: 330%2C E(): 3.2e-13%2C (35.1%25 identity in 271 aa overlap). Also similar to Rv0116c%2C Rv1433%2C Rv2518c%2C Rv0483 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0192;product=Conserved hypothetical protein;protein_id=CCP42919.1;transl_table=11
AL123456.3	EMBL	gene	223607	223909	.	+	.	ID=gene-Rv0192A;Name=Rv0192A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0192A
AL123456.3	EMBL	CDS	223607	223909	.	+	0	ID=cds-CCP42920.1;Parent=gene-Rv0192A;Dbxref=EnsemblGenomes-Gn:Rv0192A,EnsemblGenomes-Tr:CCP42920,UniProtKB/TrEMBL:Q79FZ8,NCBI_GP:CCP42920.1;Name=CCP42920.1;Note=Rv0192A%2C len: 100 aa. Probable N-terminal part of Rv0192%2C which is member of family P5.17 with Rv0116c%2CRv1433%2C Rv2518c%2C Rv0483. These are all predicted to be exported/membrane proteins. Rv0192A has typical N-terminal signal peptide which is functional and was identified by PhoA fusion screens: O52054 PGB14T-O1 precursor (fragment 45 AA) (see Chubb et al.%2C 1998). Since Rv0192 misses a signal peptide this suggests that there is a frameshift in the region of the overlap with Rv0192 but none found on reinspection of sequence.;gbkey=CDS;locus_tag=Rv0192A;product=Conserved secreted protein;protein_id=CCP42920.1;transl_table=11
AL123456.3	EMBL	gene	224724	226571	.	-	.	ID=gene-Rv0193c;Name=Rv0193c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0193c
AL123456.3	EMBL	CDS	224724	226571	.	-	0	ID=cds-CCP42921.1;Parent=gene-Rv0193c;Dbxref=EnsemblGenomes-Gn:Rv0193c,EnsemblGenomes-Tr:CCP42921,UniProtKB/TrEMBL:O07437,NCBI_GP:CCP42921.1;Name=CCP42921.1;Note=Rv0193c%2C (MTV033.01c-MTCI28.32)%2C len: 615 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0193c;product=Hypothetical protein;protein_id=CCP42921.1;transl_table=11
AL123456.3	EMBL	gene	226878	230462	.	+	.	ID=gene-Rv0194;Name=Rv0194;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0194
AL123456.3	EMBL	CDS	226878	230462	.	+	0	ID=cds-CCP42922.1;Parent=gene-Rv0194;Dbxref=EnsemblGenomes-Gn:Rv0194,EnsemblGenomes-Tr:CCP42922,GOA:O53645,InterPro:IPR001140,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR011527,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O53645,NCBI_GP:CCP42922.1;Name=CCP42922.1;Note=Rv0194%2C (MTV033.02)%2C len: 1194 aa. Probable multidrug efflux pump (See Danilchanka et al.%2C 2008)%2Chighly similar to many e.g. U62129|STU62129_2|T30293 ABC transport protein homolog from Salmonella typhi (1218 aa)%2CFASTA scores: opt: 1116%2C E(): 0%2C (36.3%25 identity in 1209 aa overlap)%3B CAB66302.1|AL136519 ABC transporter protein ATP-binding component from Streptomyces coelicolor (1243 aa)%3B I84547 mdl protein from Escherichia coli (1143 aa)%3B etc. Also similar to MTCY50_9 and MTCY50_10 from Mycobacterium tuberculosis%2C FASTA score: (33.8%25 identity in 574 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop) and one PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters). Alternative start possible at 1823 but no RBS.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv0194;product=Probable transmembrane multidrug efflux pump;protein_id=CCP42922.1;transl_table=11
AL123456.3	EMBL	gene	230899	231534	.	+	.	ID=gene-Rv0195;Name=Rv0195;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0195
AL123456.3	EMBL	CDS	230899	231534	.	+	0	ID=cds-CCP42923.1;Parent=gene-Rv0195;Dbxref=EnsemblGenomes-Gn:Rv0195,EnsemblGenomes-Tr:CCP42923,GOA:O53646,InterPro:IPR000792,InterPro:IPR011991,InterPro:IPR016032,UniProtKB/TrEMBL:O53646,NCBI_GP:CCP42923.1;Name=CCP42923.1;Note=Rv0195%2C (MTV033.03)%2C len: 211 aa. Possible two-component response regulator%2C luxR family%2C similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa)%2C FASTA scores: opt: 232%2C E(): 7.3e-09%2C (29.2%25 identity in 219 aa overlap). Start chosen by similarity. Contains probable helix-turn-helix motif at aa 166-187 (Score 1164%2C +3.15 SD).;gbkey=CDS;locus_tag=Rv0195;product=Possible two component transcriptional regulatory protein (probably LuxR-family);protein_id=CCP42923.1;transl_table=11
AL123456.3	EMBL	gene	231647	232231	.	+	.	ID=gene-Rv0196;Name=Rv0196;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0196
AL123456.3	EMBL	CDS	231647	232231	.	+	0	ID=cds-CCP42924.1;Parent=gene-Rv0196;Dbxref=EnsemblGenomes-Gn:Rv0196,EnsemblGenomes-Tr:CCP42924,GOA:P9WME1,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,NCBI_GP:CCP42924.1;Name=CCP42924.1;Note=Rv0196%2C (MTV033.04)%2C len: 194 aa. Possible transcriptional regulatory protein%2C similar to two Bacillus subtilis regulators: P42105|YXAF_BACSU hypothetical 21.0 kDa protein (191 aa)%2C FASTA scores: opt: 323%2C E(): 2.1e-15%2C(30.9%25 identity in 181 aa overlap)%3B and Z99105|BSUB0002_9 negative regulator of the lincomycin operon (188 aa)%2C FASTA scores: opt: 255%2C E(): 1e-10%2C (25.9 identity in 185 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0196;product=Possible transcriptional regulatory protein;protein_id=CCP42924.1;transl_table=11
AL123456.3	EMBL	gene	232231	234519	.	+	.	ID=gene-Rv0197;Name=Rv0197;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0197
AL123456.3	EMBL	CDS	232231	234519	.	+	0	ID=cds-CCP42925.1;Parent=gene-Rv0197;Dbxref=EnsemblGenomes-Gn:Rv0197,EnsemblGenomes-Tr:CCP42925,GOA:L0T2Z1,InterPro:IPR006656,InterPro:IPR006657,InterPro:IPR006963,InterPro:IPR009010,UniProtKB/TrEMBL:L0T2Z1,NCBI_GP:CCP42925.1;Name=CCP42925.1;Note=Rv0197%2C (MTV033.05)%2C len: 762 aa. Possible oxidoreductase%2C similar to others e.g. 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin oxidoreductase from Pseudomonas aeruginosa strain PAO1 (769 aa)%3B 5441785|CAB46809.1|AL096811|T36812 probable dehydrogenase from Streptomyces coelicolor (747 aa)%2C FASTA scores: opt: 617%2C E(): 9.8e-30%2C (29.9%25 identity in 762 aa overlap)%3B BAB04334.1|AP001509 assimilatory nitrate reductase (catalytic subunit) from Bacillus halodurans (743 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0197;product=Possible oxidoreductase;protein_id=CCP42925.1;transl_table=11
AL123456.3	EMBL	gene	234516	236507	.	-	.	ID=gene-Rv0198c;Name=zmp1;gbkey=Gene;gene=zmp1;gene_biotype=protein_coding;locus_tag=Rv0198c
AL123456.3	EMBL	CDS	234516	236507	.	-	0	ID=cds-CCP42926.1;Parent=gene-Rv0198c;Dbxref=EnsemblGenomes-Gn:Rv0198c,EnsemblGenomes-Tr:CCP42926,GOA:I6X8R2,InterPro:IPR000718,InterPro:IPR008753,InterPro:IPR018497,InterPro:IPR024079,UniProtKB/TrEMBL:I6X8R2,NCBI_GP:CCP42926.1;Name=CCP42926.1;Note=Rv0198c%2C (MTV033.06c)%2C len: 663 aa. Probable zmp1%2Czinc metalloprotease%2C equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa)%2C FASTA scores: opt: 3710%2CE(): 0%2C (80.8 %25 identity in 667 aa overlap). Also similar to many other metalloproteases e.g. members of the eukaryotic neprilysin family: P08473|NEP_HUMAN neprilysin (749 aa)%2C FASTA scores: opt: 872%2C E(): 0%2C (31.1%25 identity in 692 aa overlap)%3B Q07744|PEPO_LACLA neutral endopeptidase from Lactococcus lactis (626 aa)%2C FASTA scores: opt: 862%2CE(): 0%2C (30.0%25 identity in 654 aa overlap). Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Belongs to peptidase family M13 (zinc metalloprotease)%3B also known as the neprilysin subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=zmp1;inference=protein motif:PROSITE:PS00142;locus_tag=Rv0198c;product=Probable zinc metalloprotease Zmp1;protein_id=CCP42926.1;transl_table=11
AL123456.3	EMBL	gene	236550	237209	.	+	.	ID=gene-Rv0199;Name=Rv0199;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0199
AL123456.3	EMBL	CDS	236550	237209	.	+	0	ID=cds-CCP42927.1;Parent=gene-Rv0199;Dbxref=EnsemblGenomes-Gn:Rv0199,EnsemblGenomes-Tr:CCP42927,GOA:O53650,UniProtKB/TrEMBL:O53650,NCBI_GP:CCP42927.1;Name=CCP42927.1;Note=Rv0199%2C (MTV033.07)%2C len: 219 aa. Probable conserved membrane protein%2C equivalent to Z95398|MLCL622.13 from Mycobacterium leprae (224 aa)%2C FASTA scores: opt: 920%2C E(): 0%2C (67.7%25 identity in 220 aa overlap). Also some similarity to Mce-associated membrane proteins from Mycobacterium tuberculosis e.g. Rv0178%2C Rv0175%2C etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0199;product=Probable conserved membrane protein;protein_id=CCP42927.1;transl_table=11
AL123456.3	EMBL	gene	237206	237895	.	+	.	ID=gene-Rv0200;Name=Rv0200;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0200
AL123456.3	EMBL	CDS	237206	237895	.	+	0	ID=cds-CCP42928.1;Parent=gene-Rv0200;Dbxref=EnsemblGenomes-Gn:Rv0200,EnsemblGenomes-Tr:CCP42928,GOA:O53651,UniProtKB/TrEMBL:O53651,NCBI_GP:CCP42928.1;Name=CCP42928.1;Note=Rv0200%2C (MTV033.08)%2C len: 229 aa. Possible conserved transmembrane protein%2C equivalent to Z95398|MLCL622.14 from Mycobacterium leprae (229 aa)%2C FASTA scores: opt: 1147%2CE(): 0%2C (74.7%25 identity in 229 aa overlap). Also some similarity to Rv1973 from Mycobacterium tuberculosis (160 aa)%3B and Rv1362c|Z75555|MTCY02B10_26 (220 aa)%2C FASTA scores: opt: 134%2C E(): 0.063%2C (25.8%25 identity in 159 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0200;product=Possible conserved transmembrane protein;protein_id=CCP42928.1;transl_table=11
AL123456.3	EMBL	gene	237892	238395	.	-	.	ID=gene-Rv0201c;Name=Rv0201c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0201c
AL123456.3	EMBL	CDS	237892	238395	.	-	0	ID=cds-CCP42929.1;Parent=gene-Rv0201c;Dbxref=EnsemblGenomes-Gn:Rv0201c,EnsemblGenomes-Tr:CCP42929,GOA:O53652,UniProtKB/TrEMBL:O53652,NCBI_GP:CCP42929.1;Name=CCP42929.1;Note=Rv0201c%2C (MTV033.09c)%2C len: 167 aa. Conserved protein%2C equivalent to Z95398|MLCL622.15c from Mycobacterium leprae (170 aa)%2C FASTA scores: opt: 646%2C E(): 0%2C (63.9%25 identity in 158 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0201c;product=Conserved protein;protein_id=CCP42929.1;transl_table=11
AL123456.3	EMBL	gene	238392	241292	.	-	.	ID=gene-Rv0202c;Name=mmpL11;gbkey=Gene;gene=mmpL11;gene_biotype=protein_coding;locus_tag=Rv0202c
AL123456.3	EMBL	CDS	238392	241292	.	-	0	ID=cds-CCP42930.1;Parent=gene-Rv0202c;Dbxref=EnsemblGenomes-Gn:Rv0202c,EnsemblGenomes-Tr:CCP42930,GOA:P9WJT9,InterPro:IPR000731,InterPro:IPR004869,NCBI_GP:CCP42930.1;Name=CCP42930.1;Note=Rv0202c%2C (MTV033.10c)%2C len: 966 aa. Probable mmpL11%2Cconserved transmembrane transport protein (see citation below)%2C equivalent to Z95398|MLCL622.16c from Mycobacterium leprae (1014 aa)%2C FASTA scores: opt: 4076%2C E(): 0%2C (72.8%25 identity in 1017 aa overlap). Member of RND superfamily%2Csimilar to several putative transport proteins e.g. P96687 from Bacillus subtilis (724 aa)%2C FASTA scores: opt: 594%2CE(): 9.1e-29%2C (26.9%25 identity in 717 aa overlap)%3B etc. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL11;locus_tag=Rv0202c;product=Probable conserved transmembrane transport protein MmpL11;protein_id=CCP42930.1;transl_table=11
AL123456.3	EMBL	gene	241514	241924	.	+	.	ID=gene-Rv0203;Name=Rv0203;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0203
AL123456.3	EMBL	CDS	241514	241924	.	+	0	ID=cds-CCP42931.1;Parent=gene-Rv0203;Dbxref=EnsemblGenomes-Gn:Rv0203,EnsemblGenomes-Tr:CCP42931,UniProtKB/TrEMBL:I6X8R5,NCBI_GP:CCP42931.1;Name=CCP42931.1;Note=Rv0203%2C (MTV033.11)%2C len: 136 aa. Possible exported protein (has hydrophobic stretch near N-terminus). Some similarity to part of U02459|LDU02459_1 hypothetical protein from Leishmania donovani (741 aa)%2C FASTA score: opt: 111%2C E(): 9.1%2C (30.0%25 identity in 90 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0203;product=Possible exported protein;protein_id=CCP42931.1;transl_table=11
AL123456.3	EMBL	gene	241976	243214	.	-	.	ID=gene-Rv0204c;Name=Rv0204c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0204c
AL123456.3	EMBL	CDS	241976	243214	.	-	0	ID=cds-CCP42932.1;Parent=gene-Rv0204c;Dbxref=EnsemblGenomes-Gn:Rv0204c,EnsemblGenomes-Tr:CCP42932,GOA:I6Y748,InterPro:IPR022791,UniProtKB/TrEMBL:I6Y748,NCBI_GP:CCP42932.1;Name=CCP42932.1;Note=Rv0204c%2C (MTV033.12c)%2C len: 412 aa. Probable conserved transmembrane protein (see citation below)%2Cequivalent%2C but has C-terminal extension%2C to Z95398|MLCL622.17c from Mycobacterium leprae (367 aa)%2CFASTA scores: opt: 2002%2C E(): 0%2C (82.4%25 identity in 374 aa overlap). Some similarity to Rv0585c from Mycobacterium tuberculosis. Nucleotide position 242299 in the genome sequence has been corrected%2C C:G resulting in V306L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0204c;product=Probable conserved transmembrane protein;protein_id=CCP42932.1;transl_table=11
AL123456.3	EMBL	gene	243384	244487	.	+	.	ID=gene-Rv0205;Name=Rv0205;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0205
AL123456.3	EMBL	CDS	243384	244487	.	+	0	ID=cds-CCP42933.1;Parent=gene-Rv0205;Dbxref=EnsemblGenomes-Gn:Rv0205,EnsemblGenomes-Tr:CCP42933,GOA:P9WFM5,InterPro:IPR002549,NCBI_GP:CCP42933.1;Name=CCP42933.1;Note=Rv0205%2C (MTV033.13)%2C len: 367 aa. Possible conserved transmembrane protein%2C similar to hypothetical proteins from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces coelicolor (402 aa)%2C FASTA scores: opt: 436%2C E(): 1.7e-21%2C(27.2%25 identity in 349 aa overlap)%3B Z99117|BSUB0014_221 from Bacillus subtilis (353 aa)%2C FASTA scores: opt: 394%2CE(): 8.6e-19%2C (28.7%25 identity in 324 aa overla).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0205;product=Probable conserved transmembrane protein;protein_id=CCP42933.1;transl_table=11
AL123456.3	EMBL	gene	244484	247318	.	-	.	ID=gene-Rv0206c;Name=mmpL3;gbkey=Gene;gene=mmpL3;gene_biotype=protein_coding;locus_tag=Rv0206c
AL123456.3	EMBL	CDS	244484	247318	.	-	0	ID=cds-CCP42934.1;Parent=gene-Rv0206c;Dbxref=EnsemblGenomes-Gn:Rv0206c,EnsemblGenomes-Tr:CCP42934,GOA:P9WJV5,InterPro:IPR000731,InterPro:IPR004869,NCBI_GP:CCP42934.1;Name=CCP42934.1;Note=Rv0206c%2C (MTV033.14c%2C MTCY08D5.01c)%2C len: 944 aa. Possible mmpL3%2C conserved transmembrane transport protein (see Tekaia et al.%2C 1999)%2C equivalent to Z95398|MLCL622.18c from Mycobacterium leprae (955 aa)%2C FASTA scores: opt: 806%2CE(): 1.8e-21%2C (57.2%25 identity in 243 aa overlap). Member of RND superfamily%2C similar to others. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL3;locus_tag=Rv0206c;product=Possible conserved transmembrane transport protein MmpL3;protein_id=CCP42934.1;transl_table=11
AL123456.3	EMBL	gene	247384	248112	.	-	.	ID=gene-Rv0207c;Name=Rv0207c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0207c
AL123456.3	EMBL	CDS	247384	248112	.	-	0	ID=cds-CCP42935.1;Parent=gene-Rv0207c;Dbxref=EnsemblGenomes-Gn:Rv0207c,EnsemblGenomes-Tr:CCP42935,GOA:P96389,InterPro:IPR021139,InterPro:IPR029060,UniProtKB/TrEMBL:P96389,NCBI_GP:CCP42935.1;Name=CCP42935.1;Note=Rv0207c%2C (MTCY08D5.02c)%2C len: 242 aa. Conserved hypothetical protein%2C equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa)%2C FASTA scores: E(): 0%2C (60.8 identity in 199 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0207c;product=Conserved hypothetical protein;protein_id=CCP42935.1;transl_table=11
AL123456.3	EMBL	gene	248115	248906	.	-	.	ID=gene-Rv0208c;Name=Rv0208c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0208c
AL123456.3	EMBL	CDS	248115	248906	.	-	0	ID=cds-CCP42936.1;Parent=gene-Rv0208c;Dbxref=EnsemblGenomes-Gn:Rv0208c,EnsemblGenomes-Tr:CCP42936,GOA:P9WFY9,InterPro:IPR003358,InterPro:IPR029063,NCBI_GP:CCP42936.1;Name=CCP42936.1;Note=Rv0208c%2C (MTCY08D5.03c)%2C len: 263 aa. Hypothetical methyltransferase%2C equivalent to Z95398|MLCL622_20 from Mycobacterium leprae (279 aa)%2C FASTA score: (64.2%25 identity in 246 aa overlaps). Also similar to others e.g. 10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c hypothetical methlytransferase from Streptomyces coelicolor (271 aa). Could start at aa 7.;gbkey=CDS;locus_tag=Rv0208c;product=Hypothetical methlytransferase (methylase);protein_id=CCP42936.1;transl_table=11
AL123456.3	EMBL	gene	249038	250123	.	+	.	ID=gene-Rv0209;Name=Rv0209;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0209
AL123456.3	EMBL	CDS	249038	250123	.	+	0	ID=cds-CCP42937.1;Parent=gene-Rv0209;Dbxref=EnsemblGenomes-Gn:Rv0209,EnsemblGenomes-Tr:CCP42937,GOA:P96391,UniProtKB/TrEMBL:P96391,NCBI_GP:CCP42937.1;Name=CCP42937.1;Note=Rv0209%2C (MTCY08D5.04)%2C len: 361 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0209;product=Hypothetical protein;protein_id=CCP42937.1;transl_table=11
AL123456.3	EMBL	gene	250120	251598	.	+	.	ID=gene-Rv0210;Name=Rv0210;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0210
AL123456.3	EMBL	CDS	250120	251598	.	+	0	ID=cds-CCP42938.1;Parent=gene-Rv0210;Dbxref=EnsemblGenomes-Gn:Rv0210,EnsemblGenomes-Tr:CCP42938,UniProtKB/TrEMBL:P96392,NCBI_GP:CCP42938.1;Name=CCP42938.1;Note=Rv0210%2C (MTCY08D5.05)%2C len: 492 aa. Hypothetical unknown protein. Possibly membrane protein%3B has hydrophobic stretches around aa 333 - 381.;gbkey=CDS;locus_tag=Rv0210;product=Hypothetical protein;protein_id=CCP42938.1;transl_table=11
AL123456.3	EMBL	gene	251782	253602	.	+	.	ID=gene-Rv0211;Name=pckA;gbkey=Gene;gene=pckA;gene_biotype=protein_coding;gene_synonym=pck1,pckG;locus_tag=Rv0211
AL123456.3	EMBL	CDS	251782	253602	.	+	0	ID=cds-CCP42939.1;Parent=gene-Rv0211;Dbxref=EnsemblGenomes-Gn:Rv0211,EnsemblGenomes-Tr:CCP42939,GOA:P9WIH3,InterPro:IPR008209,InterPro:IPR008210,InterPro:IPR013035,InterPro:IPR018091,NCBI_GP:CCP42939.1;Name=CCP42939.1;Note=Rv0211%2C (MTCY08D5.06)%2C len: 606 aa. Probable pckA (alternate gene names: pckG and pck1)%2C iron-regulated phosphoenolpyruvate carboxykinase [GTP]%2C equivalent to Z95398|MLCL622_21 probable phosphoenolpyruvate carboxykinase from Mycobacterium leprae (609 aa)%2C FASTA score: (86.1%25 identity in 605 aa overlap). Also highly similar to others e.g. PPCK_NEOFR|P22130 phosphoenolpyruvate carboxykinase [GTP] (608 aa)%2C FASTA scores: opt: 2287%2C E(): 0%2C (55.9%25 identity in 598 aa overlap). Contains PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pckA;inference=protein motif:PROSITE:PS00505;locus_tag=Rv0211;product=Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase);protein_id=CCP42939.1;transl_table=11
AL123456.3	EMBL	gene	253669	254640	.	-	.	ID=gene-Rv0212c;Name=nadR;gbkey=Gene;gene=nadR;gene_biotype=protein_coding;gene_synonym=nadI;locus_tag=Rv0212c
AL123456.3	EMBL	CDS	253669	254640	.	-	0	ID=cds-CCP42940.1;Parent=gene-Rv0212c;Dbxref=EnsemblGenomes-Gn:Rv0212c,EnsemblGenomes-Tr:CCP42940,GOA:P96394,InterPro:IPR004821,InterPro:IPR006417,InterPro:IPR014729,InterPro:IPR016429,InterPro:IPR027417,UniProtKB/TrEMBL:P96394,NCBI_GP:CCP42940.1;Name=CCP42940.1;Note=Rv0212c%2C (MTCY08D5.07c)%2C len: 323 aa. Possible nadR (alternate gene name: nadI)%2C transcriptional regulator%2Csimilar to others e.g. NADR_ECOLI|P27278 transcriptional regulator from Escherichia coli (410 aa)%2C FASTA scores: opt: 377%2C E (): 1e-17%2C (31.1%25 identity in 347 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;gene=nadR;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0212c;product=Possible transcriptional regulatory protein NadR (probably AsnC-family);protein_id=CCP42940.1;transl_table=11
AL123456.3	EMBL	gene	254637	255950	.	-	.	ID=gene-Rv0213c;Name=Rv0213c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0213c
AL123456.3	EMBL	CDS	254637	255950	.	-	0	ID=cds-CCP42941.1;Parent=gene-Rv0213c;Dbxref=EnsemblGenomes-Gn:Rv0213c,EnsemblGenomes-Tr:CCP42941,GOA:P96395,InterPro:IPR006158,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR023404,InterPro:IPR023970,UniProtKB/TrEMBL:P96395,NCBI_GP:CCP42941.1;Name=CCP42941.1;Note=Rv0213c%2C (MTCY08D5.08c)%2C len: 437 aa. Possible methyltransferase%2C weakly similar to others methyltransferases e.g. AF127374_30|LINA from Streptomyces lavendulae (611 aa)%2C FASTA scores: opt: 400%2C E(): 8.1e-19%2C(27.3%25 identity in 388 aa overlap)%3B Q50258 fortimicin kl1 methyltransferase (553 aa)%2C FASTA scores: opt: 267%2C E(): 1.2e-13%2C (29.3%25 identity in 351 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0213c;product=Possible methyltransferase (methylase);protein_id=CCP42941.1;transl_table=11
AL123456.3	EMBL	gene	256064	257677	.	+	.	ID=gene-Rv0214;Name=fadD4;gbkey=Gene;gene=fadD4;gene_biotype=protein_coding;locus_tag=Rv0214
AL123456.3	EMBL	CDS	256064	257677	.	+	0	ID=cds-CCP42942.1;Parent=gene-Rv0214;Dbxref=EnsemblGenomes-Gn:Rv0214,EnsemblGenomes-Tr:CCP42942,GOA:P96396,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:P96396,NCBI_GP:CCP42942.1;Name=CCP42942.1;Note=Rv0214%2C (MTCY08D5.09)%2C len: 537 aa. Probable fadD4%2Cfatty-acid-CoA synthetase%2C similar to many e.g. 4CL_PINTA|P41636 4-coumarate--CoA ligase (537 aa)%2C FASTA scores: opt: 622%2C E(): 1e-31%2C (30.0%25 identity in 514 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY6A4.14 FASTA score: (30.7%25 identity in 501 aa overlap)%3B MTCY493_27%2C MTCY07A7_11%2C MTCI28_6. Contains PS00455 putative AMP-binding domain signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD4;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0214;product=Probable fatty-acid-CoA ligase FadD4 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP42942.1;transl_table=11
AL123456.3	EMBL	gene	257783	258856	.	-	.	ID=gene-Rv0215c;Name=fadE3;gbkey=Gene;gene=fadE3;gene_biotype=protein_coding;locus_tag=Rv0215c
AL123456.3	EMBL	CDS	257783	258856	.	-	0	ID=cds-CCP42943.1;Parent=gene-Rv0215c;Dbxref=EnsemblGenomes-Gn:Rv0215c,EnsemblGenomes-Tr:CCP42943,GOA:P96397,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P96397,NCBI_GP:CCP42943.1;Name=CCP42943.1;Note=Rv0215c%2C (MTCY08D5.10c)%2C len: 357 aa. Probable fadE3%2C acyl- dehydrogenase%2C similar to many e.g. ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis (379 aa)%2C FASTA scores: opt: 812%2C E(): 0%2C (39.5%25 identity in 354 aa overlap).;gbkey=CDS;gene=fadE3;locus_tag=Rv0215c;product=Probable acyl-CoA dehydrogenase FadE3;protein_id=CCP42943.1;transl_table=11
AL123456.3	EMBL	gene	258913	259926	.	+	.	ID=gene-Rv0216;Name=Rv0216;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0216
AL123456.3	EMBL	CDS	258913	259926	.	+	0	ID=cds-CCP42944.1;Parent=gene-Rv0216;Dbxref=EnsemblGenomes-Gn:Rv0216,EnsemblGenomes-Tr:CCP42944,InterPro:IPR016790,InterPro:IPR029069,UniProtKB/TrEMBL:I6Y340,NCBI_GP:CCP42944.1;Name=CCP42944.1;Note=Rv0216%2C (MTCY08D5.11)%2C len: 337 aa. Double hotdog R-specific hydratase of unknown function%2C shows no activity for crotonyl-CoA%2C equivalent to Z95398|MLCL622_22 from Mycobacterium leprae (339 aa)%2C FASTA scores: E(): 0%2C (73.7 identity in 338 aa overlap). Shows structural similarity to six others in Mycobacterium tuberculosis (see Castell et al (2005) below). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0216;product=Double hotdog hydratase;protein_id=CCP42944.1;transl_table=11
AL123456.3	EMBL	gene	259923	260831	.	-	.	ID=gene-Rv0217c;Name=lipW;gbkey=Gene;gene=lipW;gene_biotype=protein_coding;locus_tag=Rv0217c
AL123456.3	EMBL	CDS	259923	260831	.	-	0	ID=cds-CCP42945.1;Parent=gene-Rv0217c;Dbxref=EnsemblGenomes-Gn:Rv0217c,EnsemblGenomes-Tr:CCP42945,GOA:P96399,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:P96399,NCBI_GP:CCP42945.1;Name=CCP42945.1;Note=Rv0217c%2C (MTCY08D5.12c)%2C len: 302 aa. Possible esterase%2C showing similarity with others e.g. EST_ACICA|P18773 esterase (303 aa)%2C FASTA scores: opt: 320%2CE(): 3.2e-13%2C (29.2%25 identity in 274 aa overlap).;gbkey=CDS;gene=lipW;locus_tag=Rv0217c;product=Possible esterase LipW;protein_id=CCP42945.1;transl_table=11
AL123456.3	EMBL	gene	260924	262252	.	+	.	ID=gene-Rv0218;Name=Rv0218;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0218
AL123456.3	EMBL	CDS	260924	262252	.	+	0	ID=cds-CCP42946.1;Parent=gene-Rv0218;Dbxref=EnsemblGenomes-Gn:Rv0218,EnsemblGenomes-Tr:CCP42946,GOA:P96400,InterPro:IPR000572,UniProtKB/TrEMBL:P96400,NCBI_GP:CCP42946.1;Name=CCP42946.1;Note=Rv0218%2C (MTCY08D5.13)%2C len: 442 aa. Probable conserved transmembrane protein%2C some similarity with sulfite oxidases e.g. SUOX_HUMAN|P51687 sulfite oxidase precursor (488 aa)%2C FASTA scores: opt: 153%2C E(): 0.0087%2C(28.6%25 identity in 161 aa overlap)%3B and with some nitrate reductases e.g. NIA_FUSOX|P39863 nitrate reductase (NADPH) (905 aa)%2C FASTA scores: opt: 143%2C E(): 0.06%2C (29.3%25 identity in 92 aa overlap). Also similar to BSUB0017_86 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0218;product=Probable conserved transmembrane protein;protein_id=CCP42946.1;transl_table=11
AL123456.3	EMBL	gene	262254	262802	.	+	.	ID=gene-Rv0219;Name=Rv0219;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0219
AL123456.3	EMBL	CDS	262254	262802	.	+	0	ID=cds-CCP42947.1;Parent=gene-Rv0219;Dbxref=EnsemblGenomes-Gn:Rv0219,EnsemblGenomes-Tr:CCP42947,GOA:P96401,UniProtKB/TrEMBL:P96401,NCBI_GP:CCP42947.1;Name=CCP42947.1;Note=Rv0219%2C (MTCY08D5.14)%2C len: 182 aa. Probable conserved transmembrane protein%2C showing similarity with CAB76992.1|AL159178 putative lipoprotein from Streptomyces coelicolor (163 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0219;product=Probable conserved transmembrane protein;protein_id=CCP42947.1;transl_table=11
AL123456.3	EMBL	gene	262812	264023	.	+	.	ID=gene-Rv0220;Name=lipC;gbkey=Gene;gene=lipC;gene_biotype=protein_coding;locus_tag=Rv0220
AL123456.3	EMBL	CDS	262812	264023	.	+	0	ID=cds-CCP42948.1;Parent=gene-Rv0220;Dbxref=EnsemblGenomes-Gn:Rv0220,EnsemblGenomes-Tr:CCP42948,GOA:P96402,InterPro:IPR013094,InterPro:IPR019826,InterPro:IPR029058,UniProtKB/TrEMBL:P96402,NCBI_GP:CCP42948.1;Name=CCP42948.1;Note=Rv0220%2C (MTCY08D5.15)%2C len: 403 aa. Probable esterase%2C similar to others proteins and esterases from various organisms and Mycobacterium tuberculosis e.g. Q50681 (431 aa)%2C FASTA scores: opt: 841%2C E(): 0%2C (38.2%25 identity in 408 aa overlap)%3B Rv1426c%2C Rv1399c%2C etc. Contains PS00122 Carboxylesterases type-B serine active site.;gbkey=CDS;gene=lipC;inference=protein motif:PROSITE:PS00122;locus_tag=Rv0220;product=Probable esterase LipC;protein_id=CCP42948.1;transl_table=11
AL123456.3	EMBL	gene	264067	265476	.	+	.	ID=gene-Rv0221;Name=Rv0221;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0221
AL123456.3	EMBL	CDS	264067	265476	.	+	0	ID=cds-CCP42949.1;Parent=gene-Rv0221;Dbxref=EnsemblGenomes-Gn:Rv0221,EnsemblGenomes-Tr:CCP42949,GOA:P9WKB7,InterPro:IPR004255,InterPro:IPR009721,InterPro:IPR014292,NCBI_GP:CCP42949.1;Name=CCP42949.1;Note=Rv0221%2C (MTCY08D5.16)%2C len: 469 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C similar to other proteins from Mycobacterium tuberculosis e.g. Q50680|Rv2285|MT2343|MTCY339.25c 47.7 kDa protein (445 aa)%2CFASTA scores: opt: 455%2C E(): 8.1e-23%2C (26.7%25 identity in 461 aa overlap)%3B Rv3740c%2C Rv3734c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0221;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP42949.1;transl_table=11
AL123456.3	EMBL	gene	265507	266295	.	+	.	ID=gene-Rv0222;Name=echA1;gbkey=Gene;gene=echA1;gene_biotype=protein_coding;locus_tag=Rv0222
AL123456.3	EMBL	CDS	265507	266295	.	+	0	ID=cds-CCP42950.1;Parent=gene-Rv0222;Dbxref=EnsemblGenomes-Gn:Rv0222,EnsemblGenomes-Tr:CCP42950,GOA:P96404,InterPro:IPR001753,InterPro:IPR014748,InterPro:IPR018376,InterPro:IPR029045,UniProtKB/TrEMBL:P96404,NCBI_GP:CCP42950.1;Name=CCP42950.1;Note=Rv0222%2C (MTCY08D5.17)%2C len: 262 aa. Probable echA1%2Cenoyl-CoA hydratase%2C similar to others e.g. AAC77915.1|AF063588 enoyl CoA hydratase from Rhodococcus fascians (275 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA1;locus_tag=Rv0222;product=Probable enoyl-CoA hydratase EchA1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP42950.1;transl_table=11
AL123456.3	EMBL	gene	266301	267764	.	-	.	ID=gene-Rv0223c;Name=Rv0223c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0223c
AL123456.3	EMBL	CDS	266301	267764	.	-	0	ID=cds-CCP42951.1;Parent=gene-Rv0223c;Dbxref=EnsemblGenomes-Gn:Rv0223c,EnsemblGenomes-Tr:CCP42951,GOA:I6X8S7,InterPro:IPR015590,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR029510,UniProtKB/TrEMBL:I6X8S7,NCBI_GP:CCP42951.1;Name=CCP42951.1;Note=Rv0223c%2C (MTCY08D5.18)%2C len: 487 aa. Probable aldehyde dehydrogenase%2C similar to others e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde dehydrogenase from Deinococcus radiodurans strain R1 (495 aa)%3B Q47943 L-sorbosone dehydrogenase NAD(P) dependent from Gluconobacter oxydans (498 aa)%2C FASTA scores: opt: 1157%2C E (): 0%2C (42.1%25 identity in 482 aa overlap)%3B etc. Also similar to Rv0768%2C Rv2858c%2C etc from Mycobacterium tuberculosis. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site%3B and PS00070 Aldehyde dehydrogenases cysteine active site. Belongs to the aldehyde dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00687;locus_tag=Rv0223c;product=Probable aldehyde dehydrogenase;protein_id=CCP42951.1;transl_table=11
AL123456.3	EMBL	gene	267863	268627	.	-	.	ID=gene-Rv0224c;Name=Rv0224c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0224c
AL123456.3	EMBL	CDS	267863	268627	.	-	0	ID=cds-CCP42952.1;Parent=gene-Rv0224c;Dbxref=EnsemblGenomes-Gn:Rv0224c,EnsemblGenomes-Tr:CCP42952,GOA:P9WJZ9,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP42952.1;Name=CCP42952.1;Note=Rv0224c%2C (MTCY08D5.19c)%2C len: 254 aa. Possible methyltransferase%2C showing weak similarity with other methyltransferases e.g. P74388 sterol-C-methyltransferase (318 aa)%2C FASTA scores: opt: 190%2C E(): 3.6e-05%2C (33.3%25 identity in 114 aa overlap). Equivalent to AL022486|MLCB1883_1 from Mycobacterium leprae (269 aa)%2CFASTA scores: opt: 1456%2C E(): 0%2C (82.9%25 identity in 252 aa overlap). Also some similarity with MTCY21B4.22c from Mycobacterium tuberculosis FASTA score: (30.1%25 identity in 136 aa overlap).;gbkey=CDS;locus_tag=Rv0224c;product=Possible methyltransferase (methylase);protein_id=CCP42952.1;transl_table=11
AL123456.3	EMBL	gene	268663	269817	.	+	.	ID=gene-Rv0225;Name=Rv0225;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0225
AL123456.3	EMBL	CDS	268663	269817	.	+	0	ID=cds-CCP42953.1;Parent=gene-Rv0225;Dbxref=EnsemblGenomes-Gn:Rv0225,EnsemblGenomes-Tr:CCP42953,GOA:P96407,InterPro:IPR001296,InterPro:IPR028098,UniProtKB/TrEMBL:P96407,NCBI_GP:CCP42953.1;Name=CCP42953.1;Note=Rv0225%2C (MTCY08D5.20)%2C len: 384 aa. Possible conserved protein involved in LPS biosynthesis%2C similar to O26275 LPS biosynthesis RFBU related protein (382 aa)%2CFASTA scores: opt: 426%2C E(): 1.2e-20%2C (28.2%25 identity in 394 aa overlap). Some similarity with Rv3032 from Mycobacterium tuberculosis FASTA score: (31.6%25 identity in 228 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv0225;product=Possible conserved protein;protein_id=CCP42953.1;transl_table=11
AL123456.3	EMBL	gene	269834	271564	.	-	.	ID=gene-Rv0226c;Name=Rv0226c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0226c
AL123456.3	EMBL	CDS	269834	271564	.	-	0	ID=cds-CCP42954.1;Parent=gene-Rv0226c;Dbxref=EnsemblGenomes-Gn:Rv0226c,EnsemblGenomes-Tr:CCP42954,GOA:P96408,UniProtKB/TrEMBL:P96408,NCBI_GP:CCP42954.1;Name=CCP42954.1;Note=Rv0226c%2C (MTCY08D5.21c)%2C len: 576 aa. Probable conserved transmembrane protein%2C equivalent%2C except in N-terminal part%2C to AC32114.1|AL583926 conserved membrane protein from Mycobacterium leprae (600 aa)%2C FASTA scores: opt: 2086%2C E(): 0%2C (70.3%25 identity in 579 aa overlap). Also similar to AL021411|SC7H1_20 from Streptomyces coelicolor (483 aa)%2C FASTA scores: opt: 180%2C E(): 0.00028%2C (26.5 identity in 388 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0226c;product=Probable conserved transmembrane protein;protein_id=CCP42954.1;transl_table=11
AL123456.3	EMBL	gene	271574	272839	.	-	.	ID=gene-Rv0227c;Name=Rv0227c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0227c
AL123456.3	EMBL	CDS	271574	272839	.	-	0	ID=cds-CCP42955.1;Parent=gene-Rv0227c;Dbxref=EnsemblGenomes-Gn:Rv0227c,EnsemblGenomes-Tr:CCP42955,GOA:P96409,InterPro:IPR021424,UniProtKB/TrEMBL:P96409,NCBI_GP:CCP42955.1;Name=CCP42955.1;Note=Rv0227c%2C (MTCY08D5.22c)%2C len: 421 aa. Possible conserved membrane protein%2C equivalent to AL022486|MLCB1883_4 from Mycobacterium leprae (448 aa)%2CFASTA scores: opt: 2148%2C E(): 0%2C (76.6%25 identity in 423 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0227c;product=Probable conserved membrane protein;protein_id=CCP42955.1;transl_table=11
AL123456.3	EMBL	repeat_region	272855	272955	.	-	.	ID=id-AL123456.3:272855..272955;Note=101 bp Mycobacterial Interspersed Repetitive Unit%2Cclass III;gbkey=repeat_region
AL123456.3	EMBL	gene	273055	274278	.	+	.	ID=gene-Rv0228;Name=Rv0228;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0228
AL123456.3	EMBL	CDS	273055	274278	.	+	0	ID=cds-CCP42956.1;Parent=gene-Rv0228;Dbxref=EnsemblGenomes-Gn:Rv0228,EnsemblGenomes-Tr:CCP42956,GOA:P96410,InterPro:IPR002656,UniProtKB/TrEMBL:P96410,NCBI_GP:CCP42956.1;Name=CCP42956.1;Note=Rv0228%2C (MTCY08D5.23)%2C len: 407 aa. Probable integral membrane acyltransferase%2C equivalent to 3063875|CAA18555.1|AL022486|T44870 acyltransferase from Mycobacterium leprae (384 aa)%2C FASTA scores: opt: 2004%2CE(): 0%2C (79.3%25 identity in 381 aa overlap). Also similar to others e.g. Q11064 probable acyltransferase CY50.28C (383 aa)%2C FASTA scores: opt: 372%2C E(): 2.6e-16%2C (35.9%25 identity in 359 aa overlap)%3B Q00718|MDMB_STRMY acyltransferase. Very similar to Rv0111%2C Rv1254%2C etc from Mycobacterium tuberculosis.;gbkey=CDS;locus_tag=Rv0228;product=Probable integral membrane acyltransferase;protein_id=CCP42956.1;transl_table=11
AL123456.3	EMBL	gene	274306	274986	.	-	.	ID=gene-Rv0229c;Name=Rv0229c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0229c
AL123456.3	EMBL	CDS	274306	274986	.	-	0	ID=cds-CCP42957.1;Parent=gene-Rv0229c;Dbxref=EnsemblGenomes-Gn:Rv0229c,EnsemblGenomes-Tr:CCP42957,GOA:L0T5V6,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP42957.1;Name=CCP42957.1;Note=Rv0229c%2C (MTCY08D5.24c)%2C len: 226 aa. Possible conserved membrane protein with PIN domain in C-terminal half%2C similar to several others from Mycobacterium tuberculosis. Has some similarity with Rv2757c|D70880 from Mycobacterium tuberculosis (138 aa). (See Arcus et al.%2C2005). FASTA scores: E(): 1e-15%2C (45.3%25 identity in 137 aa overlap)%2C and Rv0301%2C Rv2546%2C etc. Also some similarity with Q48177 virulence associated protein C (132 aa)%2C FASTA scores: opt: 101%2C E(): 0.6%2C (24.3%25 identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00626;locus_tag=Rv0229c;product=Possible conserved membrane protein with PIN domain;protein_id=CCP42957.1;transl_table=11
AL123456.3	EMBL	gene	274983	275963	.	-	.	ID=gene-Rv0230c;Name=php;gbkey=Gene;gene=php;gene_biotype=protein_coding;locus_tag=Rv0230c
AL123456.3	EMBL	CDS	274983	275963	.	-	0	ID=cds-CCP42958.1;Parent=gene-Rv0230c;Dbxref=EnsemblGenomes-Gn:Rv0230c,EnsemblGenomes-Tr:CCP42958,GOA:P9WHN9,InterPro:IPR001559,InterPro:IPR017947,PDB:4IF2,NCBI_GP:CCP42958.1;Name=CCP42958.1;Note=Rv0230c%2C (MTCY08D5.26c)%2C len: 326 aa. Probable php%2Cphosphotriesterase%2C similar to others e.g. AAK42653.1|AE006849 putative aryldialkylphosphatase (phosphotriesterase) (paraoxonase) from Sulfolobus solfataricus (314 aa)%3B PHP_ECOLI|P45548 phosphotriesterase homology protein from Escherichia coli (292 aa)%2C FASTA scores: opt: 408%2C E(): 7.1e-20%2C (31.1%25 identity in 305 aa overlap)%3B OPD_FLASP|P16648 parathion hydrolase precursor (365 aa)%2C FASTA scores: opt: 319%2C E(): 5.1e-14%2C (34.5%25 identity in 333 aa overlap)%3B etc. Belongs to the phosphotriesterase family. Cofactor: contains 2 moles of zinc per subunit.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=php;locus_tag=Rv0230c;product=Probable phosphotriesterase Php (parathion hydrolase) (PTE) (aryldialkylphosphatase) (paraoxonase) (a-esterase) (aryltriphosphatase) (paraoxon hydrolase);protein_id=CCP42958.1;transl_table=11
AL123456.3	EMBL	gene	276058	277764	.	+	.	ID=gene-Rv0231;Name=fadE4;gbkey=Gene;gene=fadE4;gene_biotype=protein_coding;locus_tag=Rv0231
AL123456.3	EMBL	CDS	276058	277764	.	+	0	ID=cds-CCP42959.1;Parent=gene-Rv0231;Dbxref=EnsemblGenomes-Gn:Rv0231,EnsemblGenomes-Tr:CCP42959,GOA:P96414,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,UniProtKB/TrEMBL:P96414,NCBI_GP:CCP42959.1;Name=CCP42959.1;Note=Rv0231%2C (MTCY08D5.27)%2C len: 568 aa. Probable fadE4%2Cacyl-CoA dehydrogenase%2C similar to many e.g. O29752 acyl-CoA dehydrogenase (ACD-3) from Archaeoglobus fulgidus (576 aa)%2C FASTA scores: opt: 1788%2C E(): 0%2C (51.0%25 identity in 577 aa overlap)%3B ACDB_BACSU|P45857 acyl-CoA dehydrogenase from Bacillus subtilis (379 aa)%2C FASTA scores: opt: 232%2C E(): 2.2e- 08%2C (21.6%25 identity in 291 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE4;locus_tag=Rv0231;product=Probable acyl-CoA dehydrogenase FadE4;protein_id=CCP42959.1;transl_table=11
AL123456.3	EMBL	gene	277899	278588	.	+	.	ID=gene-Rv0232;Name=Rv0232;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0232
AL123456.3	EMBL	CDS	277899	278588	.	+	0	ID=cds-CCP42960.1;Parent=gene-Rv0232;Dbxref=EnsemblGenomes-Gn:Rv0232,EnsemblGenomes-Tr:CCP42960,GOA:P96415,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR023772,UniProtKB/TrEMBL:P96415,NCBI_GP:CCP42960.1;Name=CCP42960.1;Note=Rv0232%2C (MTCY08D5.28)%2C len: 229 aa. Probable transcriptional regulatory protein%2C TetR/AcrR family%2Csimilar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa)%2C FASTA scores: opt: 149%2CE(): 0.0014%2C (21.5%25 identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins%2C TetR family signature%2C and probable helix-turn helix motif from aa 33-54 (Score 1142%2C +3.08 SD). Belongs to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01081;locus_tag=Rv0232;product=Probable transcriptional regulatory protein (probably TetR/AcrR-family);protein_id=CCP42960.1;transl_table=11
AL123456.3	EMBL	gene	278585	279529	.	+	.	ID=gene-Rv0233;Name=nrdB;gbkey=Gene;gene=nrdB;gene_biotype=protein_coding;gene_synonym=rnrS;locus_tag=Rv0233
AL123456.3	EMBL	CDS	278585	279529	.	+	0	ID=cds-CCP42961.1;Parent=gene-Rv0233;Dbxref=EnsemblGenomes-Gn:Rv0233,EnsemblGenomes-Tr:CCP42961,GOA:P9WH69,InterPro:IPR000358,InterPro:IPR009078,InterPro:IPR012348,PDB:3EE4,PDB:4AC8,NCBI_GP:CCP42961.1;Name=CCP42961.1;Note=Rv0233%2C (MTCY08D5.29)%2C len: 314 aa. nrdB (alternate gene name: rnrS) ribonucleoside-diphosphate reductase%2C beta chain%2C similar to others e.g. RIR2_SCHPO|P36603 ribonucleoside-diphosphate reductase (391 aa)%2C FASTA scores: opt: 168%2C E(): 0.00018%2C (26.1%25 identity in 199 aa overlap)%3B etc. Belongs to the ribonucleoside diphosphate reductase small chain family. Cofactor: iron%2C manganese;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrdB;locus_tag=Rv0233;product=Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain);protein_id=CCP42961.1;transl_table=11
AL123456.3	EMBL	gene	279605	281140	.	-	.	ID=gene-Rv0234c;Name=gabD1;gbkey=Gene;gene=gabD1;gene_biotype=protein_coding;gene_synonym=gabD2;locus_tag=Rv0234c
AL123456.3	EMBL	CDS	279605	281140	.	-	0	ID=cds-CCP42962.1;Parent=gene-Rv0234c;Dbxref=EnsemblGenomes-Gn:Rv0234c,EnsemblGenomes-Tr:CCP42962,GOA:P9WNX9,InterPro:IPR015590,InterPro:IPR016160,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,NCBI_GP:CCP42962.1;Name=CCP42962.1;Note=Rv0234c%2C (MTCY08D5.30c)%2C len: 511 aa. gabD1%2Csuccinate-semialdehyde dehydrogenase [NADP+] dependent%2Cequivalent to AL022486|MLCB1883_6 probable aldehyde dehydrogenase from Mycobacterium leprae (457 aa)%2C FASTA scores: opt: 2617%2C E(): 0%2C (85.7%25 identity in 455 aa overlap). Also highly similar to Q55585|GABD|SLR0370 probable succinate-semialdehyde dehydrogenase from Synechocystis sp. strain PCC 6803 (454 aa)%2C FASTA scores: opt: 1676%2C E(): 0%2C (55.8%25 identity in 455 aa overlap)%3B and similar to others e.g. GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from Escherichia coli (482 aa)%2C FASTA scores: opt: 929%2C E(): 0%2C (36.5%25 identity in 452 aa overlap)%3B etc. Note that similar to other cytosolic aldehyde dehydrogenases with EC number: 1.2.1.3. Also similar to Rv0768|aldA semialdehyde dehydrogenase from Mycobacterium tuberculosis (489 aa)%3B and gabD2|Rv1731|MTCY04C12.16 possible succinate-semialdehyde dehydrogenase [NADP+] dependent from Mycobacterium tuberculosis (518 aa). Contains PS00070 aldehyde dehydrogenases cysteine active site. Belongs to the aldehyde dehydrogenases family. Could start at different site by homology. Note that previously known as gabD2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gabD1;inference=protein motif:PROSITE:PS00070;locus_tag=Rv0234c;product=Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1;protein_id=CCP42962.1;transl_table=11
AL123456.3	EMBL	gene	281166	282614	.	-	.	ID=gene-Rv0235c;Name=Rv0235c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0235c
AL123456.3	EMBL	CDS	281166	282614	.	-	0	ID=cds-CCP42963.1;Parent=gene-Rv0235c;Dbxref=EnsemblGenomes-Gn:Rv0235c,EnsemblGenomes-Tr:CCP42963,GOA:P96418,InterPro:IPR009613,UniProtKB/TrEMBL:P96418,NCBI_GP:CCP42963.1;Name=CCP42963.1;Note=Rv0235c%2C (MTCY08D5.31c)%2C len: 482 aa. Probable conserved transmembrane protein%2C highly similar to AL133278|CAB61913.1|SCM11_2 putative integral membrane protein from Streptomyces coelicolor (470 aa)%2C FASTA scores: opt: 2116%2C E(): 0%2C (61.8%25 identity in 474 aa overlap)%3B and similar to hypothetical proteins from other organisms e.g. Q13392|384D8_7 hypothetical protein (579 aa)%2C FASTA scores: opt: 355%2C E(): 6.9e-17%2C (28.5%25 identity in 569 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0235c;product=Probable conserved transmembrane protein;protein_id=CCP42963.1;transl_table=11
AL123456.3	EMBL	gene	282649	286851	.	-	.	ID=gene-Rv0236c;Name=aftD;gbkey=Gene;gene=aftD;gene_biotype=protein_coding;locus_tag=Rv0236c
AL123456.3	EMBL	CDS	282649	286851	.	-	0	ID=cds-CCP42964.1;Parent=gene-Rv0236c;Dbxref=EnsemblGenomes-Gn:Rv0236c,EnsemblGenomes-Tr:CCP42964,GOA:P96419,InterPro:IPR000421,InterPro:IPR008979,InterPro:IPR021798,NCBI_GP:CCP42964.1;Name=CCP42964.1;Note=Rv0236c%2C (MTV034.01c%2C MTV034.02c%2C MTCY08D5.32c)%2Clen: 1400 aa. Possible aftD%2C arabinofuranosyltransferase (See Skovierova et al.%2C 2009). Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C2003). Probable conserved transmembrane protein%2C equivalent to AL022486|CAC32102.1|MLCB1883_7 possible integral membrane protein from Mycobacterium leprae (1440 aa)%2C FASTA scores: opt: 7491%2C E(): 0%2C (78.8%25 identity in 1397 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aftD;locus_tag=Rv0236c;product=Possible arabinofuranosyltransferase AftD;protein_id=CCP42964.1;transl_table=11
AL123456.3	EMBL	gene	286898	287071	.	-	.	ID=gene-Rv0236A;Name=Rv0236A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0236A
AL123456.3	EMBL	CDS	286898	287071	.	-	0	ID=cds-CCP42965.1;Parent=gene-Rv0236A;Dbxref=EnsemblGenomes-Gn:Rv0236A,EnsemblGenomes-Tr:CCP42965,InterPro:IPR022566,NCBI_GP:CCP42965.1;Name=CCP42965.1;Note=Rv0236A%2C len: 57 aa. Small secreted protein. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0236A;product=Small secreted protein;protein_id=CCP42965.1;transl_table=11
AL123456.3	EMBL	gene	287186	288352	.	+	.	ID=gene-Rv0237;Name=lpqI;gbkey=Gene;gene=lpqI;gene_biotype=protein_coding;locus_tag=Rv0237
AL123456.3	EMBL	CDS	287186	288352	.	+	0	ID=cds-CCP42966.1;Parent=gene-Rv0237;Dbxref=EnsemblGenomes-Gn:Rv0237,EnsemblGenomes-Tr:CCP42966,GOA:L7N6B0,InterPro:IPR001764,InterPro:IPR017853,UniProtKB/TrEMBL:L7N6B0,NCBI_GP:CCP42966.1;Name=CCP42966.1;Note=Rv0237%2C (MTV034.03)%2C len: 388 aa. Probable lpQI%2Cconserved lipoprotein%2C equivalent to AL022486|MLCB1883_8|T44873 probable secreted hydrolase from Mycobacterium leprae (387 aa)%2C FASTA scores: opt: 1831%2CE(): 0%2C (73.3%25 identity in 390 aa overlap). Also similar to other lipoproteins and various hydrolases e.g. P40406|2126897|YBBD_BACSU|I39839 hypothetical 70.6 KDA lipoprotein from Bacillus subtilis (642 aa)%3B P48823|HEXA_ALTSO beta-hexosaminidase a precursor from alteromonas SP. (598 aa)%2C FASTA scores: opt: 415%2C E(): 5.8e-17%2C (31.2%25 identity in 343 aa overlap)%3B PCC6803|P74340 beta-glucosidase from Synechocystis sp. (538 aa)%2C FASTA scores: opt: 414%2C E(): 6.1e-17%2C (30.6 identity in 320 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqI;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0237;product=Probable conserved lipoprotein LpqI;protein_id=CCP42966.1;transl_table=11
AL123456.3	EMBL	gene	288428	289042	.	+	.	ID=gene-Rv0238;Name=Rv0238;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0238
AL123456.3	EMBL	CDS	288428	289042	.	+	0	ID=cds-CCP42967.1;Parent=gene-Rv0238;Dbxref=EnsemblGenomes-Gn:Rv0238,EnsemblGenomes-Tr:CCP42967,GOA:O53661,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O53661,NCBI_GP:CCP42967.1;Name=CCP42967.1;Note=Rv0238%2C (MTV034.04)%2C len: 204 aa. Possible transcriptional regulatory protein%2C TetR family%2C equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa)%2C FASTA scores: opt: 1029%2C E(): 0%2C (80.9%25 identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative TetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa)%2C FASTA scores: opt: 266%2CE(): 8.3e-12%2C (28.1%25 identity in 196 aa overlap)%3B and Rv1019 (197 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0238;product=Possible transcriptional regulatory protein (probably TetR-family);protein_id=CCP42967.1;transl_table=11
AL123456.3	EMBL	gene	289104	289337	.	+	.	ID=gene-Rv0239;Name=vapB24;gbkey=Gene;gene=vapB24;gene_biotype=protein_coding;locus_tag=Rv0239
AL123456.3	EMBL	CDS	289104	289337	.	+	0	ID=cds-CCP42968.1;Parent=gene-Rv0239;Dbxref=EnsemblGenomes-Gn:Rv0239,EnsemblGenomes-Tr:CCP42968,NCBI_GP:CCP42968.1;Name=CCP42968.1;Note=Rv0239%2C (MTV034.05)%2C len: 77 aa. Possible vapB24%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0240. Weakly similar to others e.g. Rv1839c|Z83859|MTCY359_34 from Mycobacterium tuberculosis (87 aa). See Arcus et al. 2005. FASTA scores: opt: 88%2C E(): 5%2C (40.0%25 identity in 45 aa overlap).;gbkey=CDS;gene=vapB24;locus_tag=Rv0239;product=Possible antitoxin VapB24;protein_id=CCP42968.1;transl_table=11
AL123456.3	EMBL	gene	289345	289782	.	+	.	ID=gene-Rv0240;Name=vapC24;gbkey=Gene;gene=vapC24;gene_biotype=protein_coding;locus_tag=Rv0240
AL123456.3	EMBL	CDS	289345	289782	.	+	0	ID=cds-CCP42969.1;Parent=gene-Rv0240;Dbxref=EnsemblGenomes-Gn:Rv0240,EnsemblGenomes-Tr:CCP42969,GOA:P9WF87,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP42969.1;Name=CCP42969.1;Note=Rv0240%2C (MTV034.06)%2C len: 145 aa. Possible vapC24%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0239%2Ccontains PIN domain%2C weak similarity with Rv3697c from Mycobacterium tuberculosis (145 aa). See Arcus et al. 2005. FASTA scores: opt: 145%2C E(): 7.6e-05%2C (28.0%25 identity in 143 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC24;locus_tag=Rv0240;product=Possible toxin VapC24. Contains PIN domain.;protein_id=CCP42969.1;transl_table=11
AL123456.3	EMBL	gene	289812	290654	.	-	.	ID=gene-Rv0241c;Name=htdX;gbkey=Gene;gene=htdX;gene_biotype=protein_coding;locus_tag=Rv0241c
AL123456.3	EMBL	CDS	289812	290654	.	-	0	ID=cds-CCP42970.1;Parent=gene-Rv0241c;Dbxref=EnsemblGenomes-Gn:Rv0241c,EnsemblGenomes-Tr:CCP42970,GOA:O53664,InterPro:IPR002539,InterPro:IPR003965,InterPro:IPR029069,PDB:3WEW,UniProtKB/TrEMBL:O53664,NCBI_GP:CCP42970.1;Name=CCP42970.1;Note=Rv0241c%2C (MTV034.07c)%2C len: 280 aa. Probable htdX%2C3-hydroxyacyl-thioester dehydratase (See Gurvitz et al.%2C2009)%2C highly similar to MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical protein from Mycobacterium leprae (280 aa)%2C FASTA scores: opt: 1564%2C E(): 0%2C (81.8%25 identity in 280 aa overlap)%3B and CAC32097.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (300 aa). Shows structural similarity to six others in Mycobacterium tuberculosis (see Castell et al (2005) below). Also similar to proteins from other organisms e.g. CAB77291.1|AL160312 putative dehydratase from Streptomyces coelicolor (291 aa)%3B part of BAA92930.1|AB032743 fatty acid synthetase beta subunit from Pichia angusta (2060 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=htdX;locus_tag=Rv0241c;product=Probable 3-hydroxyacyl-thioester dehydratase HtdX;protein_id=CCP42970.1;transl_table=11
AL123456.3	EMBL	gene	290665	292029	.	-	.	ID=gene-Rv0242c;Name=fabG4;gbkey=Gene;gene=fabG4;gene_biotype=protein_coding;locus_tag=Rv0242c
AL123456.3	EMBL	CDS	290665	292029	.	-	0	ID=cds-CCP42971.1;Parent=gene-Rv0242c;Dbxref=EnsemblGenomes-Gn:Rv0242c,EnsemblGenomes-Tr:CCP42971,GOA:I6Y778,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:I6Y778,NCBI_GP:CCP42971.1;Name=CCP42971.1;Note=Rv0242c%2C (MTV034.08c)%2C len: 454 aa. Probable fabG4%2C3-oxoacyl-[acyl-carrier protein] reductase%2C equivalent to 3063883|CAA18568.1|AL022486|MLCB1883_13|T44878 3-oxoacyl-[acyl-carrier protein] reductase homolog from Mycobacterium leprae (454 aa)%2C FASTA scores: opt: 2486%2CE(): 0%2C (84.8%25 identity in 454 aa overlap). C-terminal part highly similar to many FabG proteins e.g. U39441|VHU3944 1_2 from Vibrio harveyi (244 aa)%2C FASTA scores: opt: 562%2CE(): 3.4e-28%2C (40.2%25 identity in 241 aa overlap)%3B U91631|PAU91631_3 from Pseudomonas aeruginosa (247 aa)%2CFASTA scores: opt: 584%2C E(): 1.5e-29%2C (44.4%25 identity in 241 aa overlap). Has N-terminal extension of ~~200 aa and C-terminal part contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fabG4;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0242c;product=Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase);protein_id=CCP42971.1;transl_table=11
AL123456.3	EMBL	gene	292171	293493	.	+	.	ID=gene-Rv0243;Name=fadA2;gbkey=Gene;gene=fadA2;gene_biotype=protein_coding;locus_tag=Rv0243
AL123456.3	EMBL	CDS	292171	293493	.	+	0	ID=cds-CCP42972.1;Parent=gene-Rv0243;Dbxref=EnsemblGenomes-Gn:Rv0243,EnsemblGenomes-Tr:CCP42972,GOA:O86361,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020610,InterPro:IPR020616,InterPro:IPR020617,UniProtKB/TrEMBL:O86361,NCBI_GP:CCP42972.1;Name=CCP42972.1;Note=Rv0243%2C (MTV034.09)%2C len: 440 aa. Probable fadA2%2Cacetyl-CoA acyltransferase (3-acyl-CoA thiolase)%2Cequivalent%2C but shorter 17 aa%2C to AL022486|MLCB1883_14T44879 acetyltransferase from Mycobacterium leprae (457 aa)%2C FASTA scores: opt: 250 7%2CE(): 0%2C (87.6%25 identity in 435 aa overlap). Also highly similar to many e.g. G83046|PA478 probable acyl-CoA thiolase from Pseudomonas aeruginosa (425 aa)%3B AB77293.1|AL160312 putative ketoacyl CoA thiolase from Streptomyces coelicolor (428 aa)%3B P76503|7449731|YFCY_ECOLI|D65007|B2342 probable 3-ketoacyl-CoA thiolase (acetyl-CoA acyltransferase) (beta-ketothiolase) from Escherichia coli strain K-12 (436 aa)%2C FASTA scores: opt: 914%2C E(): 0%2C (38.2%25 identity in 434 aa overlap)%3B P55084|ECHB_HUMAN mitochondrial trifunctonal enzyme (474 aa)%2C FASTA scores: opt: 881%2C E(): 0%2C (37.7 identity in 451 aa overlap). Contains PS00099 Thiolases active site. Belongs to the thiolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadA2;inference=protein motif:PROSITE:PS00099;locus_tag=Rv0243;product=Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase);protein_id=CCP42972.1;transl_table=11
AL123456.3	EMBL	gene	293604	293705	.	+	.	ID=gene-F6;Name=F6;gbkey=Gene;gene=F6;gene_biotype=ncRNA;gene_synonym=mcr14,mpr13
AL123456.3	EMBL	ncRNA	293604	293705	.	+	.	ID=rna-F6;Parent=gene-F6;Note=F6%2C putative small regulatory RNA (See Arnvig and Young%2C 2009%3B DiChiara et al.%2C 2010). Alternate 3'-ends at positions 293641 and 293661.;gbkey=ncRNA;gene=F6;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	293604	293705	.	+	.	ID=exon-F6-1;Parent=rna-F6;Note=F6%2C putative small regulatory RNA (See Arnvig and Young%2C 2009%3B DiChiara et al.%2C 2010). Alternate 3'-ends at positions 293641 and 293661.;gbkey=ncRNA;gene=F6;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	293798	295633	.	-	.	ID=gene-Rv0244c;Name=fadE5;gbkey=Gene;gene=fadE5;gene_biotype=protein_coding;locus_tag=Rv0244c
AL123456.3	EMBL	CDS	293798	295633	.	-	0	ID=cds-CCP42973.1;Parent=gene-Rv0244c;Dbxref=EnsemblGenomes-Gn:Rv0244c,EnsemblGenomes-Tr:CCP42973,GOA:O53666,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,InterPro:IPR020953,InterPro:IPR025878,UniProtKB/TrEMBL:O53666,NCBI_GP:CCP42973.1;Name=CCP42973.1;Note=Rv0244c%2C (MTV034.10c)%2C len: 611 aa. Probable fadE5%2Cacyl-CoA dehydrogenase%2C equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa)%2C FASTA scores: opt: 3598%2C E(): 0%2C (89.4%25 identity in 611 aa overlap). Also highly similar to AL0211|MTV007.14 from Mycobacterium tuberculosis (609 aa)%2C FASTA scores: opt: 2576%2C E(): 0%2C(64.6%25 identity in 611 aa overlap)%3B and to various other bacterial proteins described as putative acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from Archaeoglobus fulgidus (387 aa)%2C FASTA scores: opt: 229%2C E(): 6.8e-08%2C(29.8%25 identity in 409 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE5;locus_tag=Rv0244c;product=Probable acyl-CoA dehydrogenase FadE5;protein_id=CCP42973.1;transl_table=11
AL123456.3	EMBL	gene	296005	296493	.	+	.	ID=gene-Rv0245;Name=Rv0245;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0245
AL123456.3	EMBL	CDS	296005	296493	.	+	0	ID=cds-CCP42974.1;Parent=gene-Rv0245;Dbxref=EnsemblGenomes-Gn:Rv0245,EnsemblGenomes-Tr:CCP42974,GOA:O53667,InterPro:IPR002563,InterPro:IPR012349,UniProtKB/TrEMBL:O53667,NCBI_GP:CCP42974.1;Name=CCP42974.1;Note=Rv0245%2C (MTV034.11)%2C len: 162 aa. Possible oxidoreductase%2C equivalent to AL022486|MLCB1883_17|T44882 probable oxidoreductase from Mycobacterium leprae (162 aa)%2CFASTA scores: opt: 860%2C E(): 0%2C (83.4%25 identity in 157 aa overlap). Also similar to several hypothetical proteins and various oxidoreductases e.g. AAK24246.1|AE005898 NADH:riboflavin 5'-phosphate oxidoreductase from Caulobacter crescentus (174 aa)%3B Q02058|DIM6_STRCO|CAA45048.1 actinorhodin polyketide dimerase from streptomyces coelicolor (177 aa)%2C FASTA scores: opt: 308%2C E(): 3. 2e-15%2C (37.8%25 identity in 143 aa overlap). Also similar to Z84498|Rv1939|MTCY09F9.25c from Mycobacterium tuberculosis (171 aa)%2C FASTA scores: opt: 517%2C E(): 3.5e-30%2C (49.4%25 identity in 158 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0245;product=Possible oxidoreductase;protein_id=CCP42974.1;transl_table=11
AL123456.3	EMBL	gene	296809	298119	.	+	.	ID=gene-Rv0246;Name=Rv0246;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0246
AL123456.3	EMBL	CDS	296809	298119	.	+	0	ID=cds-CCP42975.1;Parent=gene-Rv0246;Dbxref=EnsemblGenomes-Gn:Rv0246,EnsemblGenomes-Tr:CCP42975,GOA:O53668,InterPro:IPR016196,UniProtKB/TrEMBL:O53668,NCBI_GP:CCP42975.1;Name=CCP42975.1;Note=Rv0246%2C (MTV034.12)%2C len: 436 aa (start uncertain). Probable conserved integral membrane protein%2C similar to Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from Mycobacterium tuberculosis (512 aa)%2C FASTA scores: opt: 712%2C E(): 0%2C (33.2%25 identity in 422 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0246;product=Probable conserved integral membrane protein;protein_id=CCP42975.1;transl_table=11
AL123456.3	EMBL	gene	298116	298862	.	-	.	ID=gene-Rv0247c;Name=Rv0247c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0247c
AL123456.3	EMBL	CDS	298116	298862	.	-	0	ID=cds-CCP42976.1;Parent=gene-Rv0247c;Dbxref=EnsemblGenomes-Gn:Rv0247c,EnsemblGenomes-Tr:CCP42976,GOA:O53669,InterPro:IPR001041,InterPro:IPR004489,InterPro:IPR006058,InterPro:IPR009051,InterPro:IPR012675,InterPro:IPR017896,UniProtKB/TrEMBL:O53669,NCBI_GP:CCP42976.1;Name=CCP42976.1;Note=Rv0247c%2C (MTV034.13c)%2C len: 248 aa. Probable succinate dehydrogenase%2C iron-sulfur subunit%2C highly similar to CAC44313.1|AL596043 putative succinate dehydrogenase iron-sulfur subunit from Streptomyces coelicolor (259 aa)%3B and similar to iron-sulphur protein subunits of fumarate reductase or succinate dehydrogenases from many bacteria e.g. NP_147618.1|7521083|B72691 fumarate reductase iron-sulfur protein from Aeropyrum pernix (305 aa)%3B NP_069516.1|2649932|AAB90556.1|AE001057 succinate dehydrogenase iron-sulfur subunit B (sdhB) from Archaeoglobus fulgidus (236 aa)%3B etc. Also similar to Q10761|FRDB_MYCTU|7431693|F70762 fumarate reductase iron-sulfur protein from Mycobacterium tuberculosis (247 aa)%2C FASTA scores: opt: 358%2C E():1e-16%2C (31.3%25 identity in 214 aa overlap). Contains PS00197 2Fe-2S ferredoxins%2Ciron-sulfur binding region signature. Note that succinate dehydrogenase forms generally part of an enzyme complex containing four subunits: a flavoprotein (Rv0248c ?)%2C an iron-sulfur (Rv0247c ?)%2C and two hydrophobic anchor proteins (Rv0249c ?).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00197;locus_tag=Rv0247c;product=Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase);protein_id=CCP42976.1;transl_table=11
AL123456.3	EMBL	gene	298863	300803	.	-	.	ID=gene-Rv0248c;Name=Rv0248c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0248c
AL123456.3	EMBL	CDS	298863	300803	.	-	0	ID=cds-CCP42977.1;Parent=gene-Rv0248c;Dbxref=EnsemblGenomes-Gn:Rv0248c,EnsemblGenomes-Tr:CCP42977,GOA:O53670,InterPro:IPR003953,InterPro:IPR013027,InterPro:IPR015939,InterPro:IPR027477,UniProtKB/TrEMBL:O53670,NCBI_GP:CCP42977.1;Name=CCP42977.1;Note=Rv0248c%2C (MTV034.14c)%2C len: 646 aa. Probable succinate dehydrogenase%2C flavoprotein subunit%2C highly similar to flavoprotein subunit of various succinate dehydrogenases e.g. M88696|RIRSDHA_1 flavoprotein from Rickettsia prowazekii (596 aa)%2C FASTA scores: opt: 651%2CE(): 0%2C (34.6 %25 identity in 598 aa overlap). Also similar to truncated U00022_17 flavoprotein from Mycobacterium leprae (401 aa)%2C FASTA scores: opt: 677%2C E(): 0%2C (39.0%25 identity in 423 aa overlap). Note that succinate dehydrogenase forms generally part of an enzyme complex containing four subunits: a flavoprotein (Rv0248c ?)%2C an iron-sulfur (Rv0247c ?)%2C and two hydrophobic anchor proteins (Rv0249c ?).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00141;locus_tag=Rv0248c;product=Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase);protein_id=CCP42977.1;transl_table=11
AL123456.3	EMBL	gene	300834	301655	.	-	.	ID=gene-Rv0249c;Name=Rv0249c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0249c
AL123456.3	EMBL	CDS	300834	301655	.	-	0	ID=cds-CCP42978.1;Parent=gene-Rv0249c;Dbxref=EnsemblGenomes-Gn:Rv0249c,EnsemblGenomes-Tr:CCP42978,GOA:O53671,UniProtKB/TrEMBL:O53671,NCBI_GP:CCP42978.1;Name=CCP42978.1;Note=Rv0249c%2C (MTV034.15c)%2C len: 273 aa. Probable succinate dehydrogenase%2C membrane-anchor subunit for succinate dehydrogenase encoded by Rv0247c and Rv0248c. Highly similar to AC44315.1|AL596043 putative integral membrane protein from Streptomyces coelicolor (278 aa). Note that succinate dehydrogenase forms generally part of an enzyme complex containing four subunits: a flavoprotein (Rv0248c ?)%2C an iron-sulfur (Rv0247c ?)%2C and two hydrophobic anchor proteins (Rv0249c ?).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0249c;product=Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase);protein_id=CCP42978.1;transl_table=11
AL123456.3	EMBL	gene	301735	302028	.	-	.	ID=gene-Rv0250c;Name=Rv0250c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0250c
AL123456.3	EMBL	CDS	301735	302028	.	-	0	ID=cds-CCP42979.1;Parent=gene-Rv0250c;Dbxref=EnsemblGenomes-Gn:Rv0250c,EnsemblGenomes-Tr:CCP42979,NCBI_GP:CCP42979.1;Name=CCP42979.1;Note=Rv0250c%2C (MTV034.16c)%2C len: 97 aa. Conserved protein%2C equivalent to MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486 hypothetical protein from Mycobacterium leprae (98 aa)%2CFASTA scores: opt: 478%2C E(): 4.4e-28%2C (72.6%25 identity in 95 aa overlap). Also similar to C-terminus of AC44316.1|AL596043|SCBAC31E11.05c hypothetical protein from Streptomyces coelicolor (146 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0250c;product=Conserved protein;protein_id=CCP42979.1;transl_table=11
AL123456.3	EMBL	gene	302173	302652	.	-	.	ID=gene-Rv0251c;Name=hsp;gbkey=Gene;gene=hsp;gene_biotype=protein_coding;gene_synonym=acr2,hrpA,hsp20;locus_tag=Rv0251c
AL123456.3	EMBL	CDS	302173	302652	.	-	0	ID=cds-CCP42980.1;Parent=gene-Rv0251c;Dbxref=EnsemblGenomes-Gn:Rv0251c,EnsemblGenomes-Tr:CCP42980,GOA:O53673,InterPro:IPR002068,InterPro:IPR008978,UniProtKB/TrEMBL:O53673,NCBI_GP:CCP42980.1;Name=CCP42980.1;Note=Rv0251c%2C (MTV034.17c)%2C len: 159 aa. Hsp (alternate gene name: hsp20%2C hrpA%2C acr2)%2C heat-stress-induced ribosome-binding protein A (see citations below). Highly similar to AAD39038.1|AF072875_1|AF072875 putative HSP20 from Mycobacterium smegmatis (145 aa)%2C FASTA scores: opt: 479%2C E(): 2.3e-24%2C (59.9%25 identity in 157 aa overlap)%3B and similar to many bacterial and eukaryotic hsp proteins e.g. P12811|HS2C_CHLRE chloroplast heat shock 22KD protein from chlamydomonas reinhardtii (157 aa)%2C FASTA scores: opt: 184%2CE(): 1.2e-05%2C (32.4%25 identity in 142 aa overlap). Also similar to PCC6803 Spore protein sp21 from Synechocystis sp. (146 aa)%2C FASTA scores: opt: 213%2C E(): 1.2e-07%2C (30.3 identity in 145 aa overlap). Also similar to P30223|14KD_MYCTU 14 KDA antigen (16 KDA antigen) 19K major membrane protein (HSP 16.3) from Mycobacterium tuberculosis (144 aa). Belongs to the small heat shock protein (HSP20) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsp;locus_tag=Rv0251c;product=Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A);protein_id=CCP42980.1;transl_table=11
AL123456.3	EMBL	gene	302866	305427	.	+	.	ID=gene-Rv0252;Name=nirB;gbkey=Gene;gene=nirB;gene_biotype=protein_coding;gene_synonym=nasB;locus_tag=Rv0252
AL123456.3	EMBL	CDS	302866	305427	.	+	0	ID=cds-CCP42981.1;Parent=gene-Rv0252;Dbxref=EnsemblGenomes-Gn:Rv0252,EnsemblGenomes-Tr:CCP42981,GOA:O53674,InterPro:IPR001327,InterPro:IPR005117,InterPro:IPR006066,InterPro:IPR006067,InterPro:IPR007419,InterPro:IPR012744,InterPro:IPR013027,InterPro:IPR017121,InterPro:IPR023753,UniProtKB/TrEMBL:O53674,NCBI_GP:CCP42981.1;Name=CCP42981.1;Note=Rv0252%2C (MTV034.18)%2C len: 853 aa. Probable nirB (alternate gene name: nasB)%2C nitrite reductase [NAD(P)H] large subunit%2C flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI nitrite reductase (NAD(P)H) large subunit from Escherichia coli strain K12 (847 aa)%2C FASTA scores: opt: 2775%2C E(): 0%2C (49.8%25 identity in 840 aa overlap)%3B Q06458|NIRB_KLEPN nitrite reductase (NAD(P)H) large subunit (957 aa)%2C FASTA scores: opt: 2902%2CE(): 0%2C (54.2%25 identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. Homodimer which associates with NIRD|Rv0253. Cofactors: FAD%3B Iron%3B Siroheme.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nirB;inference=protein motif:PROSITE:PS00365;locus_tag=Rv0252;product=Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB;protein_id=CCP42981.1;transl_table=11
AL123456.3	EMBL	gene	305453	305809	.	+	.	ID=gene-Rv0253;Name=nirD;gbkey=Gene;gene=nirD;gene_biotype=protein_coding;locus_tag=Rv0253
AL123456.3	EMBL	CDS	305453	305809	.	+	0	ID=cds-CCP42982.1;Parent=gene-Rv0253;Dbxref=EnsemblGenomes-Gn:Rv0253,EnsemblGenomes-Tr:CCP42982,GOA:O53675,InterPro:IPR012748,InterPro:IPR017881,InterPro:IPR017941,PDB:4AIV,UniProtKB/TrEMBL:O53675,NCBI_GP:CCP42982.1;Name=CCP42982.1;Note=Rv0253%2C (MTV034.19)%2C len: 118 aa. Probable nirD%2Cnitrite reductase [NAD(P)H] small subunit%2C similar to others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia coli strains K12 and O157:H7 (108 aa)%2C FASTA scores: opt: 271%2C E():1.7e-12%2C (41.9%25 identity in 105 aa overlap). Associates with NIRB|Rv0252.;gbkey=CDS;gene=nirD;locus_tag=Rv0253;product=Probable nitrite reductase [NAD(P)H] small subunit NirD;protein_id=CCP42982.1;transl_table=11
AL123456.3	EMBL	gene	305825	306349	.	-	.	ID=gene-Rv0254c;Name=cobU;gbkey=Gene;gene=cobU;gene_biotype=protein_coding;locus_tag=Rv0254c
AL123456.3	EMBL	CDS	305825	306349	.	-	0	ID=cds-CCP42983.1;Parent=gene-Rv0254c;Dbxref=EnsemblGenomes-Gn:Rv0254c,EnsemblGenomes-Tr:CCP42983,GOA:O53676,InterPro:IPR003203,InterPro:IPR027417,UniProtKB/TrEMBL:O53676,NCBI_GP:CCP42983.1;Name=CCP42983.1;Note=Rv0254c%2C (MTV034.20)%2C len: 174 aa. Probable cobU%2Ccobalamin biosynthesis protein including a cobinamide kinase and cobinamide phosphate guanylyltransferase. Highly similar to many e.g. Q05599|COBU_SALTY cobinamide kinase / cobinamide phosphate guanylyltransferase from Salmonella typhimurium (181 aa)%2C FASTA scores: opt: 308%2C E(): 1.1e-14%2C(38.7%25 identity in 181 aa overlap)%3B P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional cobalamin biosynthesis protein cobU from Escherichia coli strains K12 and O157:H7 (181 aa)%3B part of AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa)%2C FASTA scores: opt: 445%2C E(): 3.6e-23%2C (46.0%25 identity in 176 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobU;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0254c;product=Probable bifunctional cobalamin biosynthesis protein CobU: cobinamide kinase + cobinamide phosphate guanylyltransferase;protein_id=CCP42983.1;transl_table=11
AL123456.3	EMBL	gene	306374	307858	.	-	.	ID=gene-Rv0255c;Name=cobQ1;gbkey=Gene;gene=cobQ1;gene_biotype=protein_coding;gene_synonym=cobQ;locus_tag=Rv0255c
AL123456.3	EMBL	CDS	306374	307858	.	-	0	ID=cds-CCP42984.1;Parent=gene-Rv0255c;Dbxref=EnsemblGenomes-Gn:Rv0255c,EnsemblGenomes-Tr:CCP42984,GOA:P9WP95,InterPro:IPR002586,InterPro:IPR004459,InterPro:IPR011698,InterPro:IPR017929,InterPro:IPR027417,InterPro:IPR029062,NCBI_GP:CCP42984.1;Name=CCP42984.1;Note=Rv0255c%2C (MTV034.21c)%2C len: 494 aa. Probable cobQ1%2Ccobyric acid synthase%2C similar to many e.g. Z46611|RCBLUGNS_8 cobyric acid synthase from R.capsulatus (483 aa)%2C FASTA scores: opt: 1239%2C E(): 0%2C (47.1%25 identity in 493 aa overlap)%3B P29932|COBQ_PSEDE cobyric acid synthase from Pseudomonas denitrificans (484 aa)%2C FASTA scores: opt: 1168%2C E():0%2C (44.9%25 identity in 490 aa overlap)%3B etc. Belongs to the COBB/COBQ family%2C COBQ subfamily. Note that previously known as cobQ.;gbkey=CDS;gene=cobQ1;locus_tag=Rv0255c;product=Probable cobyric acid synthase CobQ1;protein_id=CCP42984.1;transl_table=11
AL123456.3	EMBL	gene	307877	309547	.	-	.	ID=gene-Rv0256c;Name=PPE2;gbkey=Gene;gene=PPE2;gene_biotype=protein_coding;locus_tag=Rv0256c
AL123456.3	EMBL	CDS	307877	309547	.	-	0	ID=cds-CCP42985.1;Parent=gene-Rv0256c;Dbxref=EnsemblGenomes-Gn:Rv0256c,EnsemblGenomes-Tr:CCP42985,GOA:P9WI47,InterPro:IPR000030,NCBI_GP:CCP42985.1;Name=CCP42985.1;Note=Rv0256c%2C (MTV034.22c)%2C len: 556 aa. PPE2%2C Member of the M. tuberculosis PPE family%2C similar to many e.g. Rv0280%2C Rv0286%2C etc. Equivalent to Z98756|MLCB2492.30 from Mycobacterium leprae (572 aa)%2C FASTA scores: opt: 1837%2CE(): 0%2C (62.9%25 identity in 461 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE2;locus_tag=Rv0256c;product=PPE family protein PPE2;protein_id=CCP42985.1;transl_table=11
AL123456.3	EMBL	gene	309699	310073	.	+	.	ID=gene-Rv0257;Name=Rv0257;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0257
AL123456.3	EMBL	CDS	309699	310073	.	+	0	ID=cds-CCP42986.1;Parent=gene-Rv0257;Dbxref=EnsemblGenomes-Gn:Rv0257,EnsemblGenomes-Tr:CCP42986,UniProtKB/TrEMBL:L7N694,NCBI_GP:CCP42986.1;Name=CCP42986.1;Note=Rv0257%2C len: 124 aa. Hypothetical protein%2Corthologue of ML1828A conserved hypothetical protein from Mycobacterium leprae. Replaced Rv0257c (older annotation). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv0257;product=Conserved hypothetical protein;protein_id=CCP42986.1;transl_table=11
AL123456.3	EMBL	gene	310294	310749	.	-	.	ID=gene-Rv0258c;Name=Rv0258c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0258c
AL123456.3	EMBL	CDS	310294	310749	.	-	0	ID=cds-CCP42987.1;Parent=gene-Rv0258c;Dbxref=EnsemblGenomes-Gn:Rv0258c,EnsemblGenomes-Tr:CCP42987,GOA:P95215,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:P95215,NCBI_GP:CCP42987.1;Name=CCP42987.1;Note=Rv0258c%2C (MTCY06A4.02c)%2C len: 151 aa (alternative start possible). Conserved hypothetical protein%2C showing some similarity to Rv1685c|MTCI125_6 from Mycobacterium tuberculosis (207 aa)%2C FASTA scores: E(): 9.3e-07%2C (32.1%25 identity in 140 aa overlap). Also some similarity with AL049819|SCE7_13|T36295 probable transcription regulator from Streptomyces coelicolor (204 aa)%2C FASTA scores: opt: 158%2C E(): 0.00052%2C (27.0%25 identity in 111 aa overlap).;gbkey=CDS;locus_tag=Rv0258c;product=Conserved hypothetical protein;protein_id=CCP42987.1;transl_table=11
AL123456.3	EMBL	gene	310774	311517	.	-	.	ID=gene-Rv0259c;Name=Rv0259c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0259c
AL123456.3	EMBL	CDS	310774	311517	.	-	0	ID=cds-CCP42988.1;Parent=gene-Rv0259c;Dbxref=EnsemblGenomes-Gn:Rv0259c,EnsemblGenomes-Tr:CCP42988,GOA:P95216,InterPro:IPR002762,UniProtKB/TrEMBL:P95216,NCBI_GP:CCP42988.1;Name=CCP42988.1;Note=Rv0259c%2C (MTCY06A4.03c)%2C len: 247 aa. Conserved hypothetical protein%2C showing some similarity to Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis (281 aa)%2C FASTA scores: E(): 9.5e-16%2C (33.6 %25 identity in 235 aa overlap). Also some similarity with CAC33938.1|AL589708 putative secreted protein from Streptomyces coelicolor (248 aa).;gbkey=CDS;locus_tag=Rv0259c;product=Conserved hypothetical protein;protein_id=CCP42988.1;transl_table=11
AL123456.3	EMBL	gene	311514	312659	.	-	.	ID=gene-Rv0260c;Name=Rv0260c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0260c
AL123456.3	EMBL	CDS	311514	312659	.	-	0	ID=cds-CCP42989.1;Parent=gene-Rv0260c;Dbxref=EnsemblGenomes-Gn:Rv0260c,EnsemblGenomes-Tr:CCP42989,GOA:P95217,InterPro:IPR001867,InterPro:IPR003754,InterPro:IPR011991,InterPro:IPR016032,UniProtKB/TrEMBL:P95217,NCBI_GP:CCP42989.1;Name=CCP42989.1;Note=Rv0260c%2C (MTCY0A4.04c)%2C len: 381 aa. Possible two-component response regulator%2C highly similar to CAB72204.1|AL138851 putative transcriptional regulator from Streptomyces coelicolor (395 aa)%3B and similar to O34394|D69851|YJJA conserved hypothetical protein from Bacillus subtilis (270 aa)%2C FASTA scores: opt: 312%2C E(): 7.4e-14%2C (25.8%25 identity in 267 aa overlap). Also some similarity to regulatory proteins at C-terminal region e.g. CUTR_STRLI|Q03756 transcriptional regulatory protein (217 aa)%2C FASTA scores: opt: 138%2C E(): 0.02%2C (30.6%25 identity in 111 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0260c;product=Possible transcriptional regulatory protein;protein_id=CCP42989.1;transl_table=11
AL123456.3	EMBL	gene	312759	314168	.	-	.	ID=gene-Rv0261c;Name=narK3;gbkey=Gene;gene=narK3;gene_biotype=protein_coding;locus_tag=Rv0261c
AL123456.3	EMBL	CDS	312759	314168	.	-	0	ID=cds-CCP42990.1;Parent=gene-Rv0261c;Dbxref=EnsemblGenomes-Gn:Rv0261c,EnsemblGenomes-Tr:CCP42990,GOA:P95218,InterPro:IPR011701,InterPro:IPR016196,UniProtKB/TrEMBL:P95218,NCBI_GP:CCP42990.1;Name=CCP42990.1;Note=Rv0261c%2C (MTCY06A4.05c)%2C len: 469 aa. Probable nirK3%2C nitrite extrusion protein%2C integral membrane protein possibly member of major facilitator superfamily (MFS)%2Cequivalent to AAB41700.1|U72744 nitrite extrusion protein from Mycobacterium fortuitum (471 aa)%3B and 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein homolog from Mycobacterium leprae (517 aa%3B longer in N-terminus). Also similar to other nitrite extrusion proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa)%2C FASTA scores: opt: 755%2C E(): 0%2C (35.0%25 identity in 466 aa overlap). Belongs to the nark/NASA family of transporters.;gbkey=CDS;gene=narK3;locus_tag=Rv0261c;product=Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator);protein_id=CCP42990.1;transl_table=11
AL123456.3	EMBL	gene	314309	314854	.	-	.	ID=gene-Rv0262c;Name=aac;gbkey=Gene;gene=aac;gene_biotype=protein_coding;locus_tag=Rv0262c
AL123456.3	EMBL	CDS	314309	314854	.	-	0	ID=cds-CCP42991.1;Parent=gene-Rv0262c;Dbxref=EnsemblGenomes-Gn:Rv0262c,EnsemblGenomes-Tr:CCP42991,GOA:P9WQG9,InterPro:IPR000182,InterPro:IPR016181,PDB:1M44,PDB:1M4D,PDB:1M4G,PDB:1M4I,NCBI_GP:CCP42991.1;Name=CCP42991.1;Note=Rv0262c%2C (MTCY06A4.06c)%2C len: 181 aa. Aac%2Caminoglycoside 2'-N-acetyltransferase (aac(2')-IC) (see citation below)%2C highly similar to NP_302635.1|NC_002677 aminoglycoside 2'-N-acetyltransferase from Mycobacterium leprae (182 aa)%3B Q49157|AAC2_MYCFO|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium fortuitum (195 aa)%2C Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. FASTA scores: opt: 884%2CE(): 0%2C (69.1%25 identity in 181 aa overlap)%3B and P94968|AAC2_MYCSM|AAC aminoglycoside 2'-N-acetyltransferase from Mycobacterium smegmatis (210 aa) (see also citation below). Also similar to Q52424|AAC2_PROST aminoglycoside 2'-N-acetyltransferase from Providencia stuartii (178 aa). Belongs to the AAC(2')-I family of acetyltransferases. Note that previously known as aac(2')-IC.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aac;locus_tag=Rv0262c;product=Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC);protein_id=CCP42991.1;transl_table=11
AL123456.3	EMBL	gene	314864	315766	.	-	.	ID=gene-Rv0263c;Name=Rv0263c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0263c
AL123456.3	EMBL	CDS	314864	315766	.	-	0	ID=cds-CCP42992.1;Parent=gene-Rv0263c;Dbxref=EnsemblGenomes-Gn:Rv0263c,EnsemblGenomes-Tr:CCP42992,GOA:P95220,InterPro:IPR003778,InterPro:IPR029000,UniProtKB/TrEMBL:P95220,NCBI_GP:CCP42992.1;Name=CCP42992.1;Note=Rv0263c%2C (MTCY06A4.07c)%2C len: 300 aa. Conserved hypothetical protein%2C equivalent to NP_302634.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (305 aa). Also similar to others e.g. AL121596|SC51A_21 hypothetical protein from Streptomyces coelicolor (285 aa)%2CFASTA scores: opt: 714%2C E(): 0%2C (45.3%25 identity in 289 aa overlap)%3B NP_233164.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (309 aa)%3B NP_406216.1|NC_003143 conserved hypothetical protein from Yersinia pestis (316 aa)%3B YH30_HAEIN|P44298|hi1730 hypothetical protein from Haemophilus influenzae (309 aa)%2CFASTA scores: opt: 430%2C E(): 3e-20%2C (29.6%25 identity in 284 aa overlap)%3B etc. Also similar to carboxylases eg NP_415240.1|NC_000913|P75745|YBGK_ECOLI putative carboxylase from Escherichia coli strain K12 (310 aa)%2CFASTA score: (34.6%25 identity in 286 aa overlap)%3B NP_459698.1|NC_003197 putative carboxylase from Salmonella typhimurium (310 aa)%3B and to middle part of NP_420636.1|NC_002696 urea amidolyase-related protein from Caulobacter crescentus (1207 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0263c;product=Conserved hypothetical protein;protein_id=CCP42992.1;transl_table=11
AL123456.3	EMBL	gene	315783	316415	.	-	.	ID=gene-Rv0264c;Name=Rv0264c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0264c
AL123456.3	EMBL	CDS	315783	316415	.	-	0	ID=cds-CCP42993.1;Parent=gene-Rv0264c;Dbxref=EnsemblGenomes-Gn:Rv0264c,EnsemblGenomes-Tr:CCP42993,GOA:P95221,InterPro:IPR003833,InterPro:IPR024946,InterPro:IPR029000,UniProtKB/TrEMBL:P95221,NCBI_GP:CCP42993.1;Name=CCP42993.1;Note=Rv0264c%2C (MTCY06A4.08c)%2C len: 210 aa. Conserved hypothetical protein%2C equivalent to CAC32080.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (222 aa). Also similar to others hypothetical proteins e.g. AL121596|SC51A_20 from Streptomyces coelicolor (252 aa)%2CFASTA scores: opt: 420%2C E(): 2.7e-20%2C (41.7%25 identity in 204 aa overlap)%3B P75744|YBGJ_ECOLI hypothetical 23.9 KD protein from Escherichia coli (218 aa)%2C FASTA scores: E(): 2.1e-14%2C (35.7%25 identity in 182 aa overlap)%3B YH31_HAEIN|P44299|hi173 hypothetical protein from Haemophilus influenzae (213 aa)%2C FASTA scores: opt: 252%2CE(): 8.3e-10%2C (31.1%25 identity in 183 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0264c;product=Conserved hypothetical protein;protein_id=CCP42993.1;transl_table=11
AL123456.3	EMBL	gene	316511	317503	.	-	.	ID=gene-Rv0265c;Name=Rv0265c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0265c
AL123456.3	EMBL	CDS	316511	317503	.	-	0	ID=cds-CCP42994.1;Parent=gene-Rv0265c;Dbxref=EnsemblGenomes-Gn:Rv0265c,EnsemblGenomes-Tr:CCP42994,InterPro:IPR002491,InterPro:IPR006311,PDB:4PM4,UniProtKB/TrEMBL:L7N6B2,NCBI_GP:CCP42994.1;Name=CCP42994.1;Note=Rv0265c%2C (MTCY06A4.09c)%2C len: 330 aa. Probable iron-transport lipoprotein%2C most similar to T36412|5763945|CAB53324.1|AL109974 probable iron-siderophore binding lipoprotein from Streptomyces coelicolor (350 aa)%3B and (N-terminus may be incorrect) to T14166|3560508|AAC82551.1|AF027770 fxuD protein from Mycobacterium smegmatis (420 aa)%2C FASTA scores: opt: 385%2CE(): 1.5e-16%2C (32.3%25 identity in 232 aa overlap). Also similar to AAB97475.1|U02617 DtxR/iron regulated lipoprotein precursor from Corynebacterium diphtheriae (355 aa)%3B FECB_ECOLI|P15028 iron(III) dicitrate-binding periplasmic protein (300 aa)%2C FASTA scores: opt: 191%2C E(): 2.3e-05%2C (26.5%25 identity in 196 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as fecB2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0265c;product=Probable periplasmic iron-transport lipoprotein;protein_id=CCP42994.1;transl_table=11
AL123456.3	EMBL	gene	317525	321154	.	-	.	ID=gene-Rv0266c;Name=oplA;gbkey=Gene;gene=oplA;gene_biotype=protein_coding;locus_tag=Rv0266c
AL123456.3	EMBL	CDS	317525	321154	.	-	0	ID=cds-CCP42995.1;Parent=gene-Rv0266c;Dbxref=EnsemblGenomes-Gn:Rv0266c,EnsemblGenomes-Tr:CCP42995,GOA:P95223,InterPro:IPR002821,InterPro:IPR003692,InterPro:IPR008040,UniProtKB/TrEMBL:P95223,NCBI_GP:CCP42995.1;Name=CCP42995.1;Note=Rv0266c%2C (MTCY06A4.10c)%2C len: 1209 aa. Probable oplA%2C 5-oxoprolinase%2C highly similar to others or to hypothetical proteins e.g. AAK24340.1|AE005906 hydantoinase/oxoprolinase from Caulobacter crescentus (1196 aa)%3B NP_103129.1|14022305|BAB48915.1|AP002997 5-oxoprolinase from Mesorhizobium loti (1210 aa)%3B CAC48426.1|AL603642 conserved hypothetical protein from Sinorhizobium meliloti (1205 aa)%3B S77037|slr0697|1006579|BAA10729.1|D6400 hypothetical protein from Synechocystis sp. strain PCC 6803 (1252 aa)%2CFASTA scores: opt: 2016%2C E(): 0%2C (51.4%25 identity in 1247 aa overlap)%3B P97608|OPLA_RAT|T42756|11278797 5-oxoprolinase (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE) from Rattus norvegicus (1288 aa)%3B etc. Belongs to the oxoprolinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=oplA;locus_tag=Rv0266c;product=Probable 5-oxoprolinase OplA (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE);protein_id=CCP42995.1;transl_table=11
AL123456.3	EMBL	gene	321331	322722	.	+	.	ID=gene-Rv0267;Name=narU;gbkey=Gene;gene=narU;gene_biotype=protein_coding;locus_tag=Rv0267
AL123456.3	EMBL	CDS	321331	322722	.	+	0	ID=cds-CCP42996.1;Parent=gene-Rv0267;Dbxref=EnsemblGenomes-Gn:Rv0267,EnsemblGenomes-Tr:CCP42996,GOA:P95224,InterPro:IPR004737,InterPro:IPR011701,InterPro:IPR016196,UniProtKB/TrEMBL:P95224,NCBI_GP:CCP42996.1;Name=CCP42996.1;Note=Rv0267%2C (MTCY06A4.11)%2C len: 463 aa. Probable narU%2Cnitrite extrusion protein%2C integral membrane protein possibly member of major facilitator superfamily (MFS)%2Csimilar to other nitrite extrusion proteins e.g. NARU_ECOLI|P37758 nitrite extrusion protein 2 from Escherichia coli (462 aa)%2C FASTA scores: opt: 630%2C E(): 4.4e-33%2C (38.9%25 identity in 463 aa overlap)%3B and NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa)%2C FASTA scores: opt: 607%2C E(): 1.3e-31%2C (42.0%25 identity in 457 aa overlap). Also similar to Rv0261c%2C Rv2329c%2C Rv1737c%2C and to MLCB22_25 from Mycobacterium leprae (517 aa)%2C FASTA score: (35.1 identity in 459 aa overlap). Belongs to the nark/NASA family of transporters.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narU;locus_tag=Rv0267;product=Probable integral membrane nitrite extrusion protein NarU (nitrite facilitator);protein_id=CCP42996.1;transl_table=11
AL123456.3	EMBL	gene	322764	323273	.	-	.	ID=gene-Rv0268c;Name=Rv0268c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0268c
AL123456.3	EMBL	CDS	322764	323273	.	-	0	ID=cds-CCP42997.1;Parent=gene-Rv0268c;Dbxref=EnsemblGenomes-Gn:Rv0268c,EnsemblGenomes-Tr:CCP42997,InterPro:IPR006442,UniProtKB/TrEMBL:P95225,NCBI_GP:CCP42997.1;Name=CCP42997.1;Note=Rv0268c%2C (MTCY06A4.12c)%2C len: 169 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0268c;product=Hypothetical protein;protein_id=CCP42997.1;transl_table=11
AL123456.3	EMBL	gene	323338	324531	.	-	.	ID=gene-Rv0269c;Name=Rv0269c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0269c
AL123456.3	EMBL	CDS	323338	324531	.	-	0	ID=cds-CCP42998.1;Parent=gene-Rv0269c;Dbxref=EnsemblGenomes-Gn:Rv0269c,EnsemblGenomes-Tr:CCP42998,GOA:P95226,InterPro:IPR002755,UniProtKB/TrEMBL:P95226,NCBI_GP:CCP42998.1;Name=CCP42998.1;Note=Rv0269c%2C (MTCY06A4.13c)%2C len: 397 aa. Conserved hypothetical protein%2C highly similar to AL079355|SC4C6_19 hypothetical protein from Streptomyces coelicolor (341 aa)%2CFASTA scores: opt: 1019%2C E(): 0%2C (46.5%25 identity in 344 aa overlap)%2C and similar to other proteins e.g. CAC49016.1|AL603644 putative ATP-dependent DNA ligase protein from Sinorhizobium meliloti (636 aa)%3B O34398 YKOU protein from Bacillus subtilis (611 aa)%2C FASTA score: (27.2%25 identity in 283 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3062%2CRv3731 (both DNA ligases)%2C and Rv0938%2C Rv3730c.;gbkey=CDS;locus_tag=Rv0269c;product=Conserved hypothetical protein;protein_id=CCP42998.1;transl_table=11
AL123456.3	EMBL	gene	324567	326249	.	+	.	ID=gene-Rv0270;Name=fadD2;gbkey=Gene;gene=fadD2;gene_biotype=protein_coding;locus_tag=Rv0270
AL123456.3	EMBL	CDS	324567	326249	.	+	0	ID=cds-CCP42999.1;Parent=gene-Rv0270;Dbxref=EnsemblGenomes-Gn:Rv0270,EnsemblGenomes-Tr:CCP42999,GOA:P95227,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:P95227,NCBI_GP:CCP42999.1;Name=CCP42999.1;Note=Rv0270%2C (MTCY06A4.14)%2C len: 560 aa. Probable fadD2%2Cfatty-acid-CoA synthetase%2C similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa)%2C FASTA scores: opt: 544%2C E(): 2.9e-26%2C (27.7%25 identity in 535 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. MTCY493_2%2CMTCY8D5_9%2C MTCY6G11_8%2C etc. Contains PS00455 Putative AMP-binding domain signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD2;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0270;product=Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP42999.1;transl_table=11
AL123456.3	EMBL	gene	326266	328461	.	-	.	ID=gene-Rv0271c;Name=fadE6;gbkey=Gene;gene=fadE6;gene_biotype=protein_coding;locus_tag=Rv0271c
AL123456.3	EMBL	CDS	326266	328461	.	-	0	ID=cds-CCP43000.1;Parent=gene-Rv0271c;Dbxref=EnsemblGenomes-Gn:Rv0271c,EnsemblGenomes-Tr:CCP43000,GOA:P95228,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P95228,NCBI_GP:CCP43000.1;Name=CCP43000.1;Note=Rv0271c%2C (MTCY06A4.15c)%2C len: 731 aa. Probable fadE6%2C acyl-CoA dehydrogenase%2C with C-terminal half similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase (short-chain) from Homo sapiens (412 aa)%2C FASTA scores: opt: 339%2C E(): 1.3e-13%2C (28.1%25 identity in 288 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE6;locus_tag=Rv0271c;product=Probable acyl-CoA dehydrogenase FadE6;protein_id=CCP43000.1;transl_table=11
AL123456.3	EMBL	gene	328575	329708	.	-	.	ID=gene-Rv0272c;Name=Rv0272c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0272c
AL123456.3	EMBL	CDS	328575	329708	.	-	0	ID=cds-CCP43001.1;Parent=gene-Rv0272c;Dbxref=EnsemblGenomes-Gn:Rv0272c,EnsemblGenomes-Tr:CCP43001,InterPro:IPR029058,UniProtKB/TrEMBL:P95229,NCBI_GP:CCP43001.1;Name=CCP43001.1;Note=Rv0272c%2C (MTCY06A4.16c)%2C len: 377 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0272c;product=Unknown protein;protein_id=CCP43001.1;transl_table=11
AL123456.3	EMBL	gene	329705	330325	.	-	.	ID=gene-Rv0273c;Name=Rv0273c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0273c
AL123456.3	EMBL	CDS	329705	330325	.	-	0	ID=cds-CCP43002.1;Parent=gene-Rv0273c;Dbxref=EnsemblGenomes-Gn:Rv0273c,EnsemblGenomes-Tr:CCP43002,GOA:O86342,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O86342,NCBI_GP:CCP43002.1;Name=CCP43002.1;Note=Rv0273c%2C (MTV035.01c)%2C len: 206 aa (start uncertain). Possible transcriptional regulator%2C showing some similarity to hypothetical regulators from Mycobacterium tuberculosis e.g. P96222|Rv3855|MTCY01A6.13c (216 aa)%3B O08377|Rv1534|MTCY07A7A.03 (225 aa)%2C FASTA scores: opt: 123%2C E(): 3.2e-06%2C (28.5%25 identity in 172 aa overlap).;gbkey=CDS;locus_tag=Rv0273c;product=Possible transcriptional regulatory protein;protein_id=CCP43002.1;transl_table=11
AL123456.3	EMBL	gene	330422	331003	.	+	.	ID=gene-Rv0274;Name=Rv0274;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0274
AL123456.3	EMBL	CDS	330422	331003	.	+	0	ID=cds-CCP43003.1;Parent=gene-Rv0274;Dbxref=EnsemblGenomes-Gn:Rv0274,EnsemblGenomes-Tr:CCP43003,GOA:O53680,InterPro:IPR000486,InterPro:IPR004360,InterPro:IPR029068,UniProtKB/TrEMBL:O53680,NCBI_GP:CCP43003.1;Name=CCP43003.1;Note=Rv0274%2C (MTV035.02)%2C len: 193 aa. Conserved protein%2Chighly similar to AAK25058.1|AE005973 conserved hypothetical protein from Caulobacter crescentus (174 aa). Shows also some similarity to others hypothetical proteins e.g. AJ002571|BSAJ2571_7 from Bacillus subtilis (316 aa)%2CFASTA scores: opt: 138%2C E(): 0.033%2C (27.1%25 identity in 133 aa overlap). Previous hits with Q56415|M85195 fosfomycin-resistance protein from serratia marcescens (141 aa)%2C FASTA scores: opt: 82%2C E(): 1.1e -08%2C (29.1%25 identity in 151 aa overlap). Contains PS00082 Extradiol ring-cleavage dioxygenases signature near C-terminus. May belong to the vicinal-oxygen-chelate (VOC) superfamily of metalloenzymes (See Rawat et al.%2C 2003).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00082;locus_tag=Rv0274;product=Conserved protein;protein_id=CCP43003.1;transl_table=11
AL123456.3	EMBL	gene	330933	331658	.	-	.	ID=gene-Rv0275c;Name=Rv0275c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0275c
AL123456.3	EMBL	CDS	330933	331658	.	-	0	ID=cds-CCP43004.1;Parent=gene-Rv0275c;Dbxref=EnsemblGenomes-Gn:Rv0275c,EnsemblGenomes-Tr:CCP43004,GOA:L7N6A2,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:L7N6A2,NCBI_GP:CCP43004.1;Name=CCP43004.1;Note=Rv0275c%2C (MTV035.03c)%2C len: 241 aa. Possible transcriptional regulator%2C TetR family%2C similar to others e.g. Q9RJE7|SCF81.04c putative TetR-family transcriptional regulator from Streptomyces coelicolor (219 aa)%3B Q9FBI8|SCP8.33c putative TetR-family transcriptional regulator from Streptomyces coelicolor (213 aa)%3B Q9I2Q9|PA1836 probable transcriptional regulator from Pseudomonas aeruginosa (193 aa)%3B etc. Also shows some similarity with Rv0825c from Mycobacterium tuberculosis (213 aa)%2C FASTA scores: opt: 230%2C E(): 2.7e-07%2C (32.6%25 identity in 190 aa overlap). Seems to belong to the TetR/AcrR family of transcriptional regulators (M. tuberculosis regulatory protein family with many TetR orthologues).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0275c;product=Possible transcriptional regulatory protein (possibly TetR-family);protein_id=CCP43004.1;transl_table=11
AL123456.3	EMBL	gene	331748	332668	.	+	.	ID=gene-Rv0276;Name=Rv0276;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0276
AL123456.3	EMBL	CDS	331748	332668	.	+	0	ID=cds-CCP43005.1;Parent=gene-Rv0276;Dbxref=EnsemblGenomes-Gn:Rv0276,EnsemblGenomes-Tr:CCP43005,GOA:O53682,InterPro:IPR018713,UniProtKB/TrEMBL:O53682,NCBI_GP:CCP43005.1;Name=CCP43005.1;Note=Rv0276%2C (MTV035.04)%2C len: 306 aa. Conserved hypothetical protein%2C similar to Rv2237|Z70692|MTCY427.18 from Mycobacterium tuberculosis (296 aa)%2C FASTA scores: opt: 874%2C E(): 0%2C (49.6%25 identity in 282 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0276;product=Conserved hypothetical protein;protein_id=CCP43005.1;transl_table=11
AL123456.3	EMBL	gene	332708	333136	.	-	.	ID=gene-Rv0277c;Name=vapC25;gbkey=Gene;gene=vapC25;gene_biotype=protein_coding;locus_tag=Rv0277c
AL123456.3	EMBL	CDS	332708	333136	.	-	0	ID=cds-CCP43006.1;Parent=gene-Rv0277c;Dbxref=EnsemblGenomes-Gn:Rv0277c,EnsemblGenomes-Tr:CCP43006,GOA:P9WF85,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43006.1;Name=CCP43006.1;Note=Rv0277c%2C (MTV035.05c)%2C len: 142 aa. Possible vapC25%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0277A%2Ccontains PIN domain%2C see Arcus et al. 2005. Highly similar to others e.g. Rv0749|H70824|2911023|CAA17516.1|AL021958 conserved hypothetical protein from Mycobacterium tuberculosis (142 aa)%3B and Rv2530c%2C etc.;gbkey=CDS;gene=vapC25;locus_tag=Rv0277c;product=Possible toxin VapC25. Contains PIN domain.;protein_id=CCP43006.1;transl_table=11
AL123456.3	EMBL	pseudogene	333160	333417	.	-	.	ID=gene-Rv0277A;Name=vapB25;gbkey=Gene;gene=vapB25;gene_biotype=pseudogene;locus_tag=Rv0277A;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	333160	333417	.	-	0	ID=cds-Rv0277A;Parent=gene-Rv0277A;Note=Rv0277A%2C len: 85 aa. Possible vapB25%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv0277c%2C see Arcus et al. 2005. Has in-frame stop codon so may not be expressed. Very similar to others in Mycobacterium tuberculosis e.g. Rv0748 (85 aa). Fasta score E(): 4e-24%3B 88.2%25 identity in 85 aa overlap;gbkey=CDS;gene=vapB25;locus_tag=Rv0277A;product=Possible antitoxin VapB25;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	333437	336310	.	-	.	ID=gene-Rv0278c;Name=PE_PGRS3;gbkey=Gene;gene=PE_PGRS3;gene_biotype=protein_coding;locus_tag=Rv0278c
AL123456.3	EMBL	CDS	333437	336310	.	-	0	ID=cds-CCP43008.1;Parent=gene-Rv0278c;Dbxref=EnsemblGenomes-Gn:Rv0278c,EnsemblGenomes-Tr:CCP43008,InterPro:IPR000084,NCBI_GP:CCP43008.1;Name=CCP43008.1;Note=Rv0278c%2C (MTV035.06c)%2C len: 957 aa. PE_PGRS3%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C PGRS subfamily of gly-rich proteins%2C similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa)%2C FASTA scores: opt: 3849%2C E(): 0%2C(67.8%25 identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS3;inference=protein motif:PROSITE:PS00583;locus_tag=Rv0278c;product=PE-PGRS family protein PE_PGRS3;protein_id=CCP43008.1;transl_table=11
AL123456.3	EMBL	gene	336560	339073	.	-	.	ID=gene-Rv0279c;Name=PE_PGRS4;gbkey=Gene;gene=PE_PGRS4;gene_biotype=protein_coding;locus_tag=Rv0279c
AL123456.3	EMBL	CDS	336560	339073	.	-	0	ID=cds-CCP43009.1;Parent=gene-Rv0279c;Dbxref=EnsemblGenomes-Gn:Rv0279c,EnsemblGenomes-Tr:CCP43009,InterPro:IPR000084,UniProtKB/TrEMBL:L0T4W6,NCBI_GP:CCP43009.1;Name=CCP43009.1;Note=Rv0279c%2C (MTV035.07c)%2C len: 837 aa. PE_PGRS4%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C 2002)%2Csimilar to many e.g. Z95890|MTCY28_25|Rv0278c from Mycobacterium tuberculosis (914 aa)%2C FASTA scores: opt: 2677%2C E(): 0%2C (64.5%25 identity in 926 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS4;locus_tag=Rv0279c;product=PE-PGRS family protein PE_PGRS4;protein_id=CCP43009.1;transl_table=11
AL123456.3	EMBL	gene	339364	340974	.	+	.	ID=gene-Rv0280;Name=PPE3;gbkey=Gene;gene=PPE3;gene_biotype=protein_coding;locus_tag=Rv0280
AL123456.3	EMBL	CDS	339364	340974	.	+	0	ID=cds-CCP43010.1;Parent=gene-Rv0280;Dbxref=EnsemblGenomes-Gn:Rv0280,EnsemblGenomes-Tr:CCP43010,InterPro:IPR000030,NCBI_GP:CCP43010.1;Name=CCP43010.1;Note=Rv0280%2C (MTV035.08)%2C len: 536 aa. PPE3%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to others e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium tuberculosis (539 aa)%2C FASTA scores: opt: 1131%2C E(): 0%2C(51.7%25 identity in 540 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE3;locus_tag=Rv0280;product=PPE family protein PPE3;protein_id=CCP43010.1;transl_table=11
AL123456.3	EMBL	gene	340998	341906	.	+	.	ID=gene-Rv0281;Name=Rv0281;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0281
AL123456.3	EMBL	CDS	340998	341906	.	+	0	ID=cds-CCP43011.1;Parent=gene-Rv0281;Dbxref=EnsemblGenomes-Gn:Rv0281,EnsemblGenomes-Tr:CCP43011,GOA:P9WFI9,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP43011.1;Name=CCP43011.1;Note=Rv0281%2C (MTV035.09)%2C len: 302 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C member of Mycobacterium tuberculosis protein family that includes Rv0726c%2C Rv0731c%2C Rv3399%2C Rv1729c%2Cetc. MTCY31_23 (325 aa)%2C FASTA scores: opt: 1386%2C E(): 0%2C(69. 1%25 identity in 301 aa overlap). Contains possible N-terminal signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0281;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP43011.1;transl_table=11
AL123456.3	EMBL	gene	342130	344025	.	+	.	ID=gene-Rv0282;Name=eccA3;gbkey=Gene;gene=eccA3;gene_biotype=protein_coding;locus_tag=Rv0282
AL123456.3	EMBL	CDS	342130	344025	.	+	0	ID=cds-CCP43012.1;Parent=gene-Rv0282;Dbxref=EnsemblGenomes-Gn:Rv0282,EnsemblGenomes-Tr:CCP43012,GOA:P9WPI3,InterPro:IPR000641,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR023835,InterPro:IPR027417,NCBI_GP:CCP43012.1;Name=CCP43012.1;Note=Rv0282%2C (MTV035.10)%2C len: 631 aa. eccA3%2C esx conserved component%2C ESX-3 type VII secretion system protein%2C similar to Y14967|MLCB628.18c hypothetical protein from Mycobacterium leprae (573 aa)%2C FASTA scores: opt: 916%2CE(): 0%2C (38.7%25 identity in 568 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Z94121|MTY15F10.26 (619 aa)%2C FASTA scores: opt: 743%2C E(): 0%2C (29.9%25 identity in 612 aa overlap). Member of CFXQ%2C CBXP family - 9 members in Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccA3;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0282;product=ESX conserved component EccA3. ESX-3 type VII secretion system protein.;protein_id=CCP43012.1;transl_table=11
AL123456.3	EMBL	gene	344022	345638	.	+	.	ID=gene-Rv0283;Name=eccB3;gbkey=Gene;gene=eccB3;gene_biotype=protein_coding;locus_tag=Rv0283
AL123456.3	EMBL	CDS	344022	345638	.	+	0	ID=cds-CCP43013.1;Parent=gene-Rv0283;Dbxref=EnsemblGenomes-Gn:Rv0283,EnsemblGenomes-Tr:CCP43013,GOA:P9WNR3,InterPro:IPR007795,NCBI_GP:CCP43013.1;Name=CCP43013.1;Note=Rv0283%2C (MTV035.11)%2C len: 538 aa. eccB3%2C esx conserved component%2C ESX-3 type VII secretion system protein%2C possible membrane protein%2C similar to several hypothetical mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c from Mycobacterium tuberculosis (495 aa)%2C FASTA scores: opt: 698%2C E(): 0%2C (37.6%25 identity in 492 aa overlap)%3B Rv1782%3B Rv3450c%3B Rv3869%3B and Y14967|MLCB628_16|MLCB628.17c from Mycobacterium leprae (481 aa)%2C FASTA scores: opt: 672%2C E(): 1.5e-31%2C (37.2%25 identity in 506 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccB3;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0283;product=ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein.;protein_id=CCP43013.1;transl_table=11
AL123456.3	EMBL	gene	345635	349627	.	+	.	ID=gene-Rv0284;Name=eccC3;gbkey=Gene;gene=eccC3;gene_biotype=protein_coding;locus_tag=Rv0284
AL123456.3	EMBL	CDS	345635	349627	.	+	0	ID=cds-CCP43014.1;Parent=gene-Rv0284;Dbxref=EnsemblGenomes-Gn:Rv0284,EnsemblGenomes-Tr:CCP43014,GOA:P9WNA9,InterPro:IPR002543,InterPro:IPR003593,InterPro:IPR023836,InterPro:IPR023837,InterPro:IPR027417,NCBI_GP:CCP43014.1;Name=CCP43014.1;Note=Rv0284%2C (MTV035.12)%2C len: 1330 aa. eccC3%2C esx conserved component%2C ESX-3 type VII secretion system protein%2C possible membrane protein%2C similar to products of two adjacent Mycobacterium leprae genes%2C MLCB628.16c (744 aa) and MLCB628.15c (597 aa)%3B and throughout its length to several large Mycobacterium tuberculosis proteins: Rv3447c%2CRv3870%2C Rv1784%2C etc. Y14967|MLCB628_ 15 (744 aa)%2C FASTA scores: opt: 942%2C E(): 0%2C (33.8%25 identity in 730 aa overlap)%3B Y14967|MLCB628_14 (597 aa)%2C FASTA scores: opt: 613%2C E(): 3.1e-30%2C (31.7%25 identity in 615 aa overlap)%3B Z94121|MTY15F10_17 (1396 aa)%2C FASTA scores: opt: 652%2C E(): 2.2e-32%2C (35.4%25 identity in 1321 aa overlap)%3B Z95389|MTCY77_19 (1236 aa)%2C FASTA scores: opt 652%2C E(): 2.2e-32%2C (35.4%25 identity in 1321 aa overlap). Contains three PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccC3;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0284;product=ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein.;protein_id=CCP43014.1;transl_table=11
AL123456.3	EMBL	gene	349624	349932	.	+	.	ID=gene-Rv0285;Name=PE5;gbkey=Gene;gene=PE5;gene_biotype=protein_coding;locus_tag=Rv0285
AL123456.3	EMBL	CDS	349624	349932	.	+	0	ID=cds-CCP43015.1;Parent=gene-Rv0285;Dbxref=EnsemblGenomes-Gn:Rv0285,EnsemblGenomes-Tr:CCP43015,InterPro:IPR000084,UniProtKB/TrEMBL:L7N695,NCBI_GP:CCP43015.1;Name=CCP43015.1;Note=Rv0285%2C (MTV035.13)%2C len: 102 aa. PE5%2C Member of the Mycobacterium tuberculosis PE family (see Brennan %26 Delogu 2002)%2C similar to others e.g. AL0212|MTV012_37 from Mycobacterium tuberculosis (105 aa)%2C FASTA scores: opt: 497%2C E(): 2.6e-24%2C (80.4%25 identity in 102 aa overlap)%3B Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102 aa)%2C FASTA scores: opt: 413%2C E(): 3.7e-19%2C (66.7%25 identity in 102 aa overlap)%3B etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE5;locus_tag=Rv0285;product=PE family protein PE5;protein_id=CCP43015.1;transl_table=11
AL123456.3	EMBL	gene	349935	351476	.	+	.	ID=gene-Rv0286;Name=PPE4;gbkey=Gene;gene=PPE4;gene_biotype=protein_coding;locus_tag=Rv0286
AL123456.3	EMBL	CDS	349935	351476	.	+	0	ID=cds-CCP43016.1;Parent=gene-Rv0286;Dbxref=EnsemblGenomes-Gn:Rv0286,EnsemblGenomes-Tr:CCP43016,GOA:P9WI43,InterPro:IPR000030,NCBI_GP:CCP43016.1;Name=CCP43016.1;Note=Rv0286%2C (MTV035.14)%2C len: 513 aa. PPE4%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to others e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa)%2C FASTA scores: opt: 958%2C E(): 0%2C(43.5%25 identity in 522 aa overlap).;gbkey=CDS;gene=PPE4;locus_tag=Rv0286;product=PPE family protein PPE4;protein_id=CCP43016.1;transl_table=11
AL123456.3	EMBL	gene	351525	351818	.	+	.	ID=gene-Rv0287;Name=esxG;gbkey=Gene;gene=esxG;gene_biotype=protein_coding;gene_synonym=TB9.8;locus_tag=Rv0287
AL123456.3	EMBL	CDS	351525	351818	.	+	0	ID=cds-CCP43017.1;Parent=gene-Rv0287;Dbxref=EnsemblGenomes-Gn:Rv0287,EnsemblGenomes-Tr:CCP43017,GOA:O53692,InterPro:IPR010310,PDB:2KG7,UniProtKB/TrEMBL:O53692,NCBI_GP:CCP43017.1;Name=CCP43017.1;Note=Rv0287%2C (MTV035.15)%2C len: 97 aa. EsxG%2C ESAT-6 like protein. PE-family related protein%3B distant member of the Mycobacterium tuberculosis PE family%2C similar to Rv3020c|AL0212|MTV012.34 (97 aa)%2C FASTA scores: opt: 564%2CE(): 0%2C (91.8%25 identity in 97 aa overlap). Contains probable helix-turn-helix motif at aa 14-35 (Score 144%2C+4.11 SD). Seems to belong to the ESAT6 family (see Gey Van Pittius et al.%2C 2001). Note that previously known as TB9.8.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxG;locus_tag=Rv0287;product=ESAT-6 like protein EsxG (conserved protein TB9.8);protein_id=CCP43017.1;transl_table=11
AL123456.3	EMBL	gene	351848	352138	.	+	.	ID=gene-Rv0288;Name=esxH;gbkey=Gene;gene=esxH;gene_biotype=protein_coding;gene_synonym=cfp7,TB10.4;locus_tag=Rv0288
AL123456.3	EMBL	CDS	351848	352138	.	+	0	ID=cds-CCP43018.1;Parent=gene-Rv0288;Dbxref=EnsemblGenomes-Gn:Rv0288,EnsemblGenomes-Tr:CCP43018,GOA:P9WNK3,InterPro:IPR010310,PDB:2KG7,NCBI_GP:CCP43018.1;Name=CCP43018.1;Note=Rv0288%2C (MT0301%2C MTV035.16)%2C len: 96 aa. EsxH%2C low molecular weight protein antigen 7 (10 kDa antigen) (CFP-7) (Protein TB10.4) (see citations below)%2C ala-rich protein%3B member of mycobacterial protein family containing ESAT-6%2Cvery similar to MTV012_33 from Mycobacterium tuberculosis (96 aa)%2C FASTA scores: opt: 566%2C E(): 0%2C (84.4%25 identity in 96 aa overlap). Alternative start codon possible position 351878 (see Rosenkrands et al.%2C 2000). Belongs to the ESAT6 family (see Skjot et al.%2C 2000%3B 2002%3B Gey Van Pittius et al.%2C 2001). Note that previously known as cfp7 (alternate gene name: TB10.4). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxH;locus_tag=Rv0288;product=Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4);protein_id=CCP43018.1;transl_table=11
AL123456.3	EMBL	gene	352149	353036	.	+	.	ID=gene-Rv0289;Name=espG3;gbkey=Gene;gene=espG3;gene_biotype=protein_coding;locus_tag=Rv0289
AL123456.3	EMBL	CDS	352149	353036	.	+	0	ID=cds-CCP43019.1;Parent=gene-Rv0289;Dbxref=EnsemblGenomes-Gn:Rv0289,EnsemblGenomes-Tr:CCP43019,GOA:P9WJC7,InterPro:IPR025734,NCBI_GP:CCP43019.1;Name=CCP43019.1;Note=Rv0289%2C (MTV035.17)%2C len: 295 aa. EspG3%2C ESX-3 secretion-associated protein%2C equivalent to CAC32061.1|AL583926 possible DNA-binding protein from Mycobacterium leprae (289 aa)%3B and showing some similarity to Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from Mycobacterium tuberculosis (276 aa)%2C FASTA scores: opt: 149%2C E(): 0.0035%2C (27.7%25 identity in 289 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=espG3;locus_tag=Rv0289;product=ESX-3 secretion-associated protein EspG3;protein_id=CCP43019.1;transl_table=11
AL123456.3	EMBL	gene	353083	354501	.	+	.	ID=gene-Rv0290;Name=eccD3;gbkey=Gene;gene=eccD3;gene_biotype=protein_coding;locus_tag=Rv0290
AL123456.3	EMBL	CDS	353083	354501	.	+	0	ID=cds-CCP43020.1;Parent=gene-Rv0290;Dbxref=EnsemblGenomes-Gn:Rv0290,EnsemblGenomes-Tr:CCP43020,GOA:P9WNQ3,InterPro:IPR006707,InterPro:IPR024962,NCBI_GP:CCP43020.1;Name=CCP43020.1;Note=Rv0290%2C (MTV035.18)%2C len: 472 aa. EccD3%2C esx conserved component%2C ESX-3 type VII secretion system protein%2C probable transmembrane protein%2C similar to several others in mycobacteria e.g. Z95389|MTCY77_20|Rv3887c from Mycobacterium tuberculosis (467 aa)%2C FASTA scores: opt: 429%2C E(): 5.1e-19%2C (28. 6%25 identity in 479 aa overlap)%3B Rv3877%3B Rv1795%3B Rv3448%3B and Y14967|MLCB628_9|MLCB628.10c from Mycobacterium leprae (480 aa)%2C FASTA scores: opt: 269%2CE(): 3.1e-09%2C (26.0%25 identity in 503 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccD3;locus_tag=Rv0290;product=ESX conserved component EccD3. ESX-3 type VII secretion system protein. Probable transmembrane protein.;protein_id=CCP43020.1;transl_table=11
AL123456.3	EMBL	gene	354498	355883	.	+	.	ID=gene-Rv0291;Name=mycP3;gbkey=Gene;gene=mycP3;gene_biotype=protein_coding;locus_tag=Rv0291
AL123456.3	EMBL	CDS	354498	355883	.	+	0	ID=cds-CCP43021.1;Parent=gene-Rv0291;Dbxref=EnsemblGenomes-Gn:Rv0291,EnsemblGenomes-Tr:CCP43021,GOA:O53695,InterPro:IPR000209,InterPro:IPR015500,InterPro:IPR022398,InterPro:IPR023834,UniProtKB/TrEMBL:O53695,NCBI_GP:CCP43021.1;Name=CCP43021.1;Note=Rv0291%2C (MTV035.19)%2C len: 461 aa. Probable mycP3%2Cmembrane-anchored serine protease (mycosin) (see Brown et al.%2C 2000)%2C similar to several others in mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from Mycobacterium tuberculosis (446 aa)%2C FASTA scores: opt: 1168%2C E(): 0%2C (44.6%25 identity in 453 aa overlap)%3B Rv3886c%3B Rv3883c%3B Rv3449%3B and Y14967|MLCB628_4|MLCB628.04 from Mycobacterium leprae (446 aa)%2C FASTA scores: opt: 1159%2C E(): 0%2C (43.5 identity in 446 aa overlap). Has signal sequence and hydrophobic stretch at C-terminus%2C followed by short positively charged segment%2Cthat seems to act as a membrane anchor. Contains PS00137 Serine proteases%2C subtilase family%2C histidine active site signature. Belongs to peptidase family S8 (also known as the subtilase family)%2C pyrolysin subfamily. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mycP3;inference=protein motif:PROSITE:PS00137;locus_tag=Rv0291;product=Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3);protein_id=CCP43021.1;transl_table=11
AL123456.3	EMBL	gene	355880	356875	.	+	.	ID=gene-Rv0292;Name=eccE3;gbkey=Gene;gene=eccE3;gene_biotype=protein_coding;locus_tag=Rv0292
AL123456.3	EMBL	CDS	355880	356875	.	+	0	ID=cds-CCP43022.1;Parent=gene-Rv0292;Dbxref=EnsemblGenomes-Gn:Rv0292,EnsemblGenomes-Tr:CCP43022,GOA:P9WJE5,InterPro:IPR021368,NCBI_GP:CCP43022.1;Name=CCP43022.1;Note=Rv0292%2C (MTV035.20)%2C len: 331 aa. EccE3%2C esx conserved component%2C ESX-3 type VII secretion system protein%2C probable transmembrane protein (has two hydrophobic segments at N-terminal end)%2C equivalent to CAC32058.1|AL583926 conserved membrane protein from Mycobacterium leprae (339 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccE3;locus_tag=Rv0292;product=ESX conserved component EccE3. ESX-3 type VII secretion system protein. Probable transmembrane protein.;protein_id=CCP43022.1;transl_table=11
AL123456.3	EMBL	gene	356862	358064	.	-	.	ID=gene-Rv0293c;Name=Rv0293c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0293c
AL123456.3	EMBL	CDS	356862	358064	.	-	0	ID=cds-CCP43023.1;Parent=gene-Rv0293c;Dbxref=EnsemblGenomes-Gn:Rv0293c,EnsemblGenomes-Tr:CCP43023,InterPro:IPR029058,UniProtKB/TrEMBL:O53697,NCBI_GP:CCP43023.1;Name=CCP43023.1;Note=Rv0293c%2C (MTV035.21c)%2C len: 400 aa. Conserved protein%2C similar in C-terminal part to Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 conserved hypothetical protein from Mycobacterium tuberculosis (413 aa)%2C FASTA scores: opt: 394%2C E(): 2.1e-17%2C (31.1%25 identity in 299 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0293c;product=Conserved protein;protein_id=CCP43023.1;transl_table=11
AL123456.3	EMBL	gene	358171	358956	.	+	.	ID=gene-Rv0294;Name=tam;gbkey=Gene;gene=tam;gene_biotype=protein_coding;locus_tag=Rv0294
AL123456.3	EMBL	CDS	358171	358956	.	+	0	ID=cds-CCP43024.1;Parent=gene-Rv0294;Dbxref=EnsemblGenomes-Gn:Rv0294,EnsemblGenomes-Tr:CCP43024,GOA:P9WGA3,InterPro:IPR023149,InterPro:IPR023506,InterPro:IPR029063,NCBI_GP:CCP43024.1;Name=CCP43024.1;Note=Rv0294%2C (MTV035.22)%2C len: 261 aa. Probable tam%2Ctrans-aconitate methyltransferase%2C similar to others e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 trans-aconitate methyltransferase from Escherichia coli strain K12 (252 aa)%2C FASTA scores: opt: 649%2C E(): 0%2C (39.3 identity in 252 aa overlap). Belongs to the methyltransferase superfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tam;locus_tag=Rv0294;product=Probable trans-aconitate methyltransferase Tam;protein_id=CCP43024.1;transl_table=11
AL123456.3	EMBL	gene	358945	359748	.	-	.	ID=gene-Rv0295c;Name=Rv0295c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0295c
AL123456.3	EMBL	CDS	358945	359748	.	-	0	ID=cds-CCP43025.1;Parent=gene-Rv0295c;Dbxref=EnsemblGenomes-Gn:Rv0295c,EnsemblGenomes-Tr:CCP43025,GOA:O53699,InterPro:IPR015124,InterPro:IPR024628,InterPro:IPR027417,UniProtKB/TrEMBL:O53699,NCBI_GP:CCP43025.1;Name=CCP43025.1;Note=Rv0295c%2C (MTV035.23c)%2C len: 267 aa. Conserved protein%2C showing weak similarity with CAC46877.1|AL591790 conserved hypothetical protein from Sinorhizobium meliloti (213 aa)%3B and NP_104818.1|14023999|BAB50604.1|AP00300 Protein with weak similarity to NodH from Mesorhizobium loti (257 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0295c;product=Conserved protein;protein_id=CCP43025.1;transl_table=11
AL123456.3	EMBL	gene	359758	361155	.	-	.	ID=gene-Rv0296c;Name=Rv0296c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0296c
AL123456.3	EMBL	CDS	359758	361155	.	-	0	ID=cds-CCP43026.1;Parent=gene-Rv0296c;Dbxref=EnsemblGenomes-Gn:Rv0296c,EnsemblGenomes-Tr:CCP43026,GOA:Q6MX51,InterPro:IPR000917,InterPro:IPR017849,InterPro:IPR017850,InterPro:IPR024607,UniProtKB/TrEMBL:Q6MX51,NCBI_GP:CCP43026.1;Name=CCP43026.1;Note=Rv0296c%2C (MTCY63.01c%2C MTV035.24c)%2C len: 465 aa. Probable sulfatase%2C possibly an aryl-/steryl-sulfatase or a sulfamidase (sulfohydrolase) (sulphamidase). Similar to various hydrolases e.g. AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from Mus musculus (502 aa)%3B NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827 N-sulfoglucosamine sulfohydrolase (sulfamidase) (sulphamidase) from Mus musculus (502 aa)%3B AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase from Canis familiaris (507 aa)%3B P08842|STS_HUMAN|1360652 steryl-sulfatase precursor (steroid sulfatase) (steryl-sulfate sulfohydrolase) (arylsulfatase C) (ASC) from Homo sapiens (583 aa)%3B ARSB_FELCA|P33727 arylsulfatase B precursor (535 aa)%2C FASTA scores: opt: 231%2C E(): 1.7e-08%2C(30.3%25 identity in 261 aa overlap). Also similarity with 4 others sulfatases in Mycobacterium tuberculosis. Contains sulfatases signature 1 (PS00523). Note that previously known as atsG.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00523;locus_tag=Rv0296c;product=Probable sulfatase;protein_id=CCP43026.1;transl_table=11
AL123456.3	EMBL	gene	361334	363109	.	+	.	ID=gene-Rv0297;Name=PE_PGRS5;gbkey=Gene;gene=PE_PGRS5;gene_biotype=protein_coding;locus_tag=Rv0297
AL123456.3	EMBL	CDS	361334	363109	.	+	0	ID=cds-CCP43027.1;Parent=gene-Rv0297;Dbxref=EnsemblGenomes-Gn:Rv0297,EnsemblGenomes-Tr:CCP43027,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MX50,NCBI_GP:CCP43027.1;Name=CCP43027.1;Note=Rv0297%2C (MTCY63.02)%2C len: 591 aa. PE_PGRS5%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to others e.g. Y03A_MYCTU|Q10637 from Mycobacterium tuberculosis (603 aa)%2C FASTA scores: opt: 1884%2C E(): 0%2C(53.7%25 identity in 635 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS5;locus_tag=Rv0297;product=PE-PGRS family protein PE_PGRS5;protein_id=CCP43027.1;transl_table=11
AL123456.3	EMBL	gene	363252	363479	.	+	.	ID=gene-Rv0298;Name=Rv0298;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0298
AL123456.3	EMBL	CDS	363252	363479	.	+	0	ID=cds-CCP43028.1;Parent=gene-Rv0298;Dbxref=EnsemblGenomes-Gn:Rv0298,EnsemblGenomes-Tr:CCP43028,GOA:P9WJ09,InterPro:IPR002145,NCBI_GP:CCP43028.1;Name=CCP43028.1;Note=Rv0298%2C (MTCY63.03)%2C len: 75 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0298;product=Hypothetical protein;protein_id=CCP43028.1;transl_table=11
AL123456.3	EMBL	gene	363476	363778	.	+	.	ID=gene-Rv0299;Name=Rv0299;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0299
AL123456.3	EMBL	CDS	363476	363778	.	+	0	ID=cds-CCP43029.1;Parent=gene-Rv0299;Dbxref=EnsemblGenomes-Gn:Rv0299,EnsemblGenomes-Tr:CCP43029,GOA:O07226,NCBI_GP:CCP43029.1;Name=CCP43029.1;Note=Rv0299%2C (MTCY63.04)%2C len: 100 aa. Hypothetical unknown protein. Equivalent to AAK44536.1 from Mycobacterium tuberculosis strain CDC1551 (49 aa) but longer 51 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0299;product=Hypothetical protein;protein_id=CCP43029.1;transl_table=11
AL123456.3	EMBL	gene	363826	364047	.	+	.	ID=gene-Rv0300;Name=vapB2;gbkey=Gene;gene=vapB2;gene_biotype=protein_coding;locus_tag=Rv0300
AL123456.3	EMBL	CDS	363826	364047	.	+	0	ID=cds-CCP43030.1;Parent=gene-Rv0300;Dbxref=EnsemblGenomes-Gn:Rv0300,EnsemblGenomes-Tr:CCP43030,GOA:O07227,InterPro:IPR002145,InterPro:IPR010985,PDB:3H87,NCBI_GP:CCP43030.1;Name=CCP43030.1;Note=Rv0300%2C (MTCY63.05)%2C len: 73 aa. Possible vapB2%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0301 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Weak similarity with others e.g. Rv3697c from Mycobacterium tuberculosis (145 aa)%2CRv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 conserved hypothetical protein from Mycobacterium tuberculosis (75 aa)%2C FASTA scores: opt: 84%2C E(): 8.3%2C (39.5%25 identity in 38 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB2;locus_tag=Rv0300;product=Possible antitoxin VapB2;protein_id=CCP43030.1;transl_table=11
AL123456.3	EMBL	gene	364044	364469	.	+	.	ID=gene-Rv0301;Name=vapC2;gbkey=Gene;gene=vapC2;gene_biotype=protein_coding;locus_tag=Rv0301
AL123456.3	EMBL	CDS	364044	364469	.	+	0	ID=cds-CCP43031.1;Parent=gene-Rv0301;Dbxref=EnsemblGenomes-Gn:Rv0301,EnsemblGenomes-Tr:CCP43031,GOA:P9WFB9,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,PDB:3H87,NCBI_GP:CCP43031.1;Name=CCP43031.1;Note=Rv0301%2C (MTCY63.06)%2C len: 141 aa. Possible vapC2%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0300%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Rv2757c%2C Rv0229c%2C Rv2546%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC2;locus_tag=Rv0301;product=Possible toxin VapC2;protein_id=CCP43031.1;transl_table=11
AL123456.3	EMBL	gene	364605	365237	.	+	.	ID=gene-Rv0302;Name=Rv0302;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0302
AL123456.3	EMBL	CDS	364605	365237	.	+	0	ID=cds-CCP43032.1;Parent=gene-Rv0302;Dbxref=EnsemblGenomes-Gn:Rv0302,EnsemblGenomes-Tr:CCP43032,GOA:O07229,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O07229,NCBI_GP:CCP43032.1;Name=CCP43032.1;Note=Rv0302%2C (MTCY63.07)%2C len: 210 aa. Probable transcription regulatory protein%2C TetR family (see citation below)%2C with its N-terminus similar to N-terminus of several repressors and regulatory proteins of TetR/AcrR family e.g. ACRR_ECOLI|P34000 potential acraB operon repressor from Escherichia coli (215 aa)%2C FASTA scores: opt: 172%2C E(): 3.1e-05%2C (22.7%25 identity in 194 aa overlap). Also similar in N-terminus to N-terminus of MTCY07A7.24 hypothetical regulator from Mycobacterium tuberculosis FASTA score: (38.7%25 identity in 62 aa overlap). Contains probable helix-turn helix motif from aa 35-56 (Score 1728%2C+5.07 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0302;product=Probable transcriptional regulatory protein (probably TetR/AcrR-family);protein_id=CCP43032.1;transl_table=11
AL123456.3	EMBL	gene	365234	366142	.	+	.	ID=gene-Rv0303;Name=Rv0303;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0303
AL123456.3	EMBL	CDS	365234	366142	.	+	0	ID=cds-CCP43033.1;Parent=gene-Rv0303;Dbxref=EnsemblGenomes-Gn:Rv0303,EnsemblGenomes-Tr:CCP43033,GOA:O07230,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O07230,NCBI_GP:CCP43033.1;Name=CCP43033.1;Note=Rv0303%2C (MTCY63.08)%2C len: 302 aa. Possible dehydrogenase/reductase%2C similar to various NADPH dehydrogenases and other NADPH oxidoreductases e.g. O48741|PORC_ARATH|7488284|T00897 protochlorophyllide reductase C chloroplast precursor (NADPH-protochlorophyllide oxidoreductase C) from Arabidopsis thaliana (401 aa)%3B Q42850 NADPH dehydrogenase (395 aa)%2C FASTA scores: opt: 347%2C E(): 3.8e-16%2C (35.4%25 identity in 319 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0303;product=Probable dehydrogenase/reductase;protein_id=CCP43033.1;transl_table=11
AL123456.3	EMBL	gene	366150	372764	.	-	.	ID=gene-Rv0304c;Name=PPE5;gbkey=Gene;gene=PPE5;gene_biotype=protein_coding;locus_tag=Rv0304c
AL123456.3	EMBL	CDS	366150	372764	.	-	0	ID=cds-CCP43034.1;Parent=gene-Rv0304c;Dbxref=EnsemblGenomes-Gn:Rv0304c,EnsemblGenomes-Tr:CCP43034,InterPro:IPR002989,UniProtKB/TrEMBL:Q6MX49,NCBI_GP:CCP43034.1;Name=CCP43034.1;Note=Rv0304c%2C (MTCY63.9c)%2C len: 2204 aa. PPE5%2C Member of the Mycobacterium tuberculosis PE family (PPE%2C MPTR)%2Csimilar to others e.g. Z95324|MTY13E10_16 from Mycobacterium tuberculosis (1443 aa)%2C FASTA scores: E(): 0%2C(50.6%25 identity in 1403 aa overlap)%3B Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa)%2C FASTA scores: opt: 989%2C E(): 0%2C (42.3%25 identity in 522 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE5;locus_tag=Rv0304c;product=PPE family protein PPE5;protein_id=CCP43034.1;transl_table=11
AL123456.3	EMBL	gene	372820	375711	.	-	.	ID=gene-Rv0305c;Name=PPE6;gbkey=Gene;gene=PPE6;gene_biotype=protein_coding;locus_tag=Rv0305c
AL123456.3	EMBL	CDS	372820	375711	.	-	0	ID=cds-CCP43035.1;Parent=gene-Rv0305c;Dbxref=EnsemblGenomes-Gn:Rv0305c,EnsemblGenomes-Tr:CCP43035,GOA:Q6MX48,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:Q6MX48,NCBI_GP:CCP43035.1;Name=CCP43035.1;Note=Rv0305c%2C (MTCY63.10c)%2C len: 963 aa. PPE6%2C Member of the Mycobacterium tuberculosis PE family (PPE%2C MPTR)%2Csimilar to others e.g. Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa)%2C FASTA scores: opt: 1340%2C E(): 0%2C(40.9%25 identity in 815 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE6;locus_tag=Rv0305c;product=PPE family protein PPE6;protein_id=CCP43035.1;transl_table=11
AL123456.3	EMBL	gene	375914	376585	.	+	.	ID=gene-Rv0306;Name=Rv0306;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0306
AL123456.3	EMBL	CDS	375914	376585	.	+	0	ID=cds-CCP43036.1;Parent=gene-Rv0306;Dbxref=EnsemblGenomes-Gn:Rv0306,EnsemblGenomes-Tr:CCP43036,GOA:O07233,InterPro:IPR000415,InterPro:IPR012825,InterPro:IPR029479,UniProtKB/TrEMBL:O07233,NCBI_GP:CCP43036.1;Name=CCP43036.1;Note=Rv0306%2C (MTCY63.11)%2C len: 223 aa. Putative oxidoreductase%2C highly similar to H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved hypothetical protein from Pseudomonas aeruginosa strain PAO1 (218 aa)%3B and to other putative oxidoreductases e.g. middle part of CAB76073.1|AL157953 putative nitroreductase from Streptomyces coelicolor (1212 aa)%3B Q52685|BLUB protein involved in cobalamin (vitamin B12) synthesis from Rhodobacter capsulatus (206 aa)%2C FASTA scores: opt: 318%2CE(): 2e-15%2C (35.6%25 identity in 191 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0306;product=Putative oxidoreductase;protein_id=CCP43036.1;transl_table=11
AL123456.3	EMBL	gene	376573	377055	.	-	.	ID=gene-Rv0307c;Name=Rv0307c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0307c
AL123456.3	EMBL	CDS	376573	377055	.	-	0	ID=cds-CCP43037.1;Parent=gene-Rv0307c;Dbxref=EnsemblGenomes-Gn:Rv0307c,EnsemblGenomes-Tr:CCP43037,UniProtKB/TrEMBL:O07234,NCBI_GP:CCP43037.1;Name=CCP43037.1;Note=Rv0307c%2C (MTCY63.12c)%2C len: 160 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0307c;product=Unknown protein;protein_id=CCP43037.1;transl_table=11
AL123456.3	EMBL	gene	377113	377829	.	+	.	ID=gene-Rv0308;Name=Rv0308;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0308
AL123456.3	EMBL	CDS	377113	377829	.	+	0	ID=cds-CCP43038.1;Parent=gene-Rv0308;Dbxref=EnsemblGenomes-Gn:Rv0308,EnsemblGenomes-Tr:CCP43038,GOA:O07235,InterPro:IPR000326,UniProtKB/TrEMBL:O07235,NCBI_GP:CCP43038.1;Name=CCP43038.1;Note=Rv0308%2C (MTCY63.13)%2C len: 238 aa. Probable conserved integral membrane protein%2C with C-terminus highly similar to C-terminus of other integral membrane proteins or phosphatases e.g. AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1 putative phosphatase from Streptococcus pyogenes (201 aa)%3B Q06074 hypothetical 24.9 kDa protein (216 aa)%2C FASTA scores: opt: 209%2C E(): 2e-07%2C (27.9%25 identity in 140 aa overlap). Could be a phosphatase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0308;product=Probable conserved integral membrane protein;protein_id=CCP43038.1;transl_table=11
AL123456.3	EMBL	gene	377931	378587	.	+	.	ID=gene-Rv0309;Name=Rv0309;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0309
AL123456.3	EMBL	CDS	377931	378587	.	+	0	ID=cds-CCP43039.1;Parent=gene-Rv0309;Dbxref=EnsemblGenomes-Gn:Rv0309,EnsemblGenomes-Tr:CCP43039,GOA:O07236,InterPro:IPR005490,UniProtKB/TrEMBL:O07236,NCBI_GP:CCP43039.1;Name=CCP43039.1;Note=Rv0309%2C (MTCY63.14)%2C len: 218 aa. Possible conserved exported protein (has putative N-terminal signal sequence)%2Cequivalent to AC32053.1|AL583926 putative secreted protein from Mycobacterium leprae (218 aa). Also similar to others e.g. AB76092.1|AL157956 putative secreted protein from Streptomyces coelicolor (238 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0309;product=Possible conserved exported protein;protein_id=CCP43039.1;transl_table=11
AL123456.3	EMBL	gene	378657	379148	.	-	.	ID=gene-Rv0310c;Name=Rv0310c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0310c
AL123456.3	EMBL	CDS	378657	379148	.	-	0	ID=cds-CCP43040.1;Parent=gene-Rv0310c;Dbxref=EnsemblGenomes-Gn:Rv0310c,EnsemblGenomes-Tr:CCP43040,UniProtKB/TrEMBL:O07237,NCBI_GP:CCP43040.1;Name=CCP43040.1;Note=Rv0310c%2C (MTCY63.15c)%2C len: 163 aa. Conserved protein%2C similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 bile acid-inducible operon protein E from Eubacterium sp (166 aa)%2C FASTA scores: opt: 302%2C E(): 1e-11%2C (38.8%25 identity in 134 aa overlap)%3B AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0310c;product=Conserved protein;protein_id=CCP43040.1;transl_table=11
AL123456.3	EMBL	gene	379172	380401	.	+	.	ID=gene-Rv0311;Name=Rv0311;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0311
AL123456.3	EMBL	CDS	379172	380401	.	+	0	ID=cds-CCP43041.1;Parent=gene-Rv0311;Dbxref=EnsemblGenomes-Gn:Rv0311,EnsemblGenomes-Tr:CCP43041,GOA:O07238,UniProtKB/TrEMBL:O07238,NCBI_GP:CCP43041.1;Name=CCP43041.1;Note=Rv0311%2C (MTCY63.16)%2C len: 409 aa. Unknown protein. Contains PS00881 Protein splicing signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00881;locus_tag=Rv0311;product=Unknown protein;protein_id=CCP43041.1;transl_table=11
AL123456.3	EMBL	gene	380556	382418	.	+	.	ID=gene-Rv0312;Name=Rv0312;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0312
AL123456.3	EMBL	CDS	380556	382418	.	+	0	ID=cds-CCP43042.1;Parent=gene-Rv0312;Dbxref=EnsemblGenomes-Gn:Rv0312,EnsemblGenomes-Tr:CCP43042,GOA:O07239,InterPro:IPR013126,UniProtKB/TrEMBL:O07239,NCBI_GP:CCP43042.1;Name=CCP43042.1;Note=Rv0312%2C (MTCY63.17)%2C len: 620 aa. Conserved hypothetical protein with highly Pro-%2C Thr-rich C-terminus. Similar to Pro-%2CThr-rich region in Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis (592 aa)%2C FASTA scores: opt: 1075%2C E(): 0%2C (38.9%25 identity in 627 aa overlap). Also some similarity with Rv0350|dnaK from Mycobacterium tuberculosis. Possibly membrane protein%3B has hydrophobic stetch in its middle part.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0312;product=Conserved hypothetical proline and threonine rich protein;protein_id=CCP43042.1;transl_table=11
AL123456.3	EMBL	gene	382490	382876	.	+	.	ID=gene-Rv0313;Name=Rv0313;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0313
AL123456.3	EMBL	CDS	382490	382876	.	+	0	ID=cds-CCP43043.1;Parent=gene-Rv0313;Dbxref=EnsemblGenomes-Gn:Rv0313,EnsemblGenomes-Tr:CCP43043,NCBI_GP:CCP43043.1;Name=CCP43043.1;Note=Rv0313%2C (MTCY63.18)%2C len: 128 aa. Conserved protein%2Cequivalent only to CAC32049.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (130 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0313;product=Conserved protein;protein_id=CCP43043.1;transl_table=11
AL123456.3	EMBL	gene	382879	383541	.	-	.	ID=gene-Rv0314c;Name=Rv0314c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0314c
AL123456.3	EMBL	CDS	382879	383541	.	-	0	ID=cds-CCP43044.1;Parent=gene-Rv0314c;Dbxref=EnsemblGenomes-Gn:Rv0314c,EnsemblGenomes-Tr:CCP43044,InterPro:IPR021417,UniProtKB/TrEMBL:O07241,NCBI_GP:CCP43044.1;Name=CCP43044.1;Note=Rv0314c%2C (MTCY63.19c)%2C len: 220 aa. Possible conserved membrane protein%2C with hydrophobic stretch from residues ~~75-100. Similar in C-terminal part to Mycobacterium tuberculosis proteins Rv0679c and Rv0680c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0314c;product=Possible conserved membrane protein;protein_id=CCP43044.1;transl_table=11
AL123456.3	EMBL	gene	383602	384486	.	+	.	ID=gene-Rv0315;Name=Rv0315;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0315
AL123456.3	EMBL	CDS	383602	384486	.	+	0	ID=cds-CCP43045.1;Parent=gene-Rv0315;Dbxref=EnsemblGenomes-Gn:Rv0315,EnsemblGenomes-Tr:CCP43045,GOA:O07242,InterPro:IPR000757,InterPro:IPR006311,InterPro:IPR013320,UniProtKB/TrEMBL:O07242,NCBI_GP:CCP43045.1;Name=CCP43045.1;Note=Rv0315%2C (MTCY63.20)%2C len: 294 aa. Possible beta-1%2C3-glucanase precursor (has hydrophobic stretch in its N-terminal part)%2C similar to others e.g. Q51333|AAC44371.1 beta-1%2C3-glucanase II a from Oerskovia xanthineolytica (306 aa)%2C FASTA scores: opt: 76%2C E(): 3e-14%2C (34.1%25 identity in 302 aa overlap)%3B and AAC38290.1|AF052745 beta-1%2C3-glucanase II from Oerskovia xanthineolytica (435 aa). Contains glycosyl hydrolases family 16 active site signature (PS01034).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01034;locus_tag=Rv0315;product=Possible beta-1%2C3-glucanase precursor;protein_id=CCP43045.1;transl_table=11
AL123456.3	EMBL	gene	384535	385149	.	+	.	ID=gene-Rv0316;Name=Rv0316;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0316
AL123456.3	EMBL	CDS	384535	385149	.	+	0	ID=cds-CCP43046.1;Parent=gene-Rv0316;Dbxref=EnsemblGenomes-Gn:Rv0316,EnsemblGenomes-Tr:CCP43046,GOA:O07243,InterPro:IPR003464,InterPro:IPR011008,InterPro:IPR026029,UniProtKB/TrEMBL:O07243,NCBI_GP:CCP43046.1;Name=CCP43046.1;Note=Rv0316%2C (MTCY63.21)%2C len: 204 aa. Possible muconolactone isomerase%2C showing weak similarity with some muconolactone isomerases e.g. O33947|CTC1_ACILW muconolactone delta-isomerase 1 (MIASE 1)(96 aa)%2C FASTA scores: opt: 179%2C E(): 3.9e-05%2C (32.6%25 identity in 92 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0316;product=Possible muconolactone isomerase;protein_id=CCP43046.1;transl_table=11
AL123456.3	EMBL	gene	385173	385943	.	-	.	ID=gene-Rv0317c;Name=glpQ2;gbkey=Gene;gene=glpQ2;gene_biotype=protein_coding;locus_tag=Rv0317c
AL123456.3	EMBL	CDS	385173	385943	.	-	0	ID=cds-CCP43047.1;Parent=gene-Rv0317c;Dbxref=EnsemblGenomes-Gn:Rv0317c,EnsemblGenomes-Tr:CCP43047,GOA:O07244,InterPro:IPR004129,InterPro:IPR017946,UniProtKB/TrEMBL:O07244,NCBI_GP:CCP43047.1;Name=CCP43047.1;Note=Rv0317c%2C (MTCY63.22c)%2C len: 256 aa (start uncertain%2Cchosen by homology). Possible glpQ2%2C glycerophosphoryl diester phosphodiesterase%2C similar to others e.g. E75317|6459876|AAF11631.1|AE002044_4 glycerophosphoryl diester phosphodiesterase from Deinococcus radiodurans (285 aa)%3B P10908|UGPQ_ECOLI from Escherichia coli (247 aa)%2CFASTA scores: opt: 220%2C E(): 5.2e-07%2C (28.0%25 identity in 250 aa overlap). Also similar to MTCY01A6.27 from Mycobacterium tuberculosis FASTA score: (27.5%25 identity in 247 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glpQ2;locus_tag=Rv0317c;product=Possible glycerophosphoryl diester phosphodiesterase GlpQ2 (glycerophosphodiester phosphodiesterase);protein_id=CCP43047.1;transl_table=11
AL123456.3	EMBL	gene	386204	386274	.	-	.	ID=gene-glyU;Name=glyU;gbkey=Gene;gene=glyU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	386204	386274	.	-	.	ID=rna-glyU;Parent=gene-glyU;Note=codon recognized: GGG%3B glyU%2C tRNA-Gly%2C anticodon ccc%2C length %3D 71;anticodon=(pos:complement(386240..386242));gbkey=tRNA;gene=glyU;product=tRNA-Gly
AL123456.3	EMBL	exon	386204	386274	.	-	.	ID=exon-glyU-1;Parent=rna-glyU;Note=codon recognized: GGG%3B glyU%2C tRNA-Gly%2C anticodon ccc%2C length %3D 71;anticodon=(pos:complement(386240..386242));gbkey=tRNA;gene=glyU;product=tRNA-Gly
AL123456.3	EMBL	gene	386305	387099	.	-	.	ID=gene-Rv0318c;Name=Rv0318c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0318c
AL123456.3	EMBL	CDS	386305	387099	.	-	0	ID=cds-CCP43048.1;Parent=gene-Rv0318c;Dbxref=EnsemblGenomes-Gn:Rv0318c,EnsemblGenomes-Tr:CCP43048,GOA:Q6MX47,InterPro:IPR003689,UniProtKB/TrEMBL:Q6MX47,NCBI_GP:CCP43048.1;Name=CCP43048.1;Note=Rv0318c%2C (MTCY63.23c)%2C len: 264 aa. Probable conserved integral membrane protein%2C with some similarity to C-terminus of GUFA_MYXXA|Q06916 (254 aa)%2C FASTA scores: opt: 157%2C E (): 0.0032%2C (28.3%25 identity in 198 aa overlap). Also similar to O26573 conserved protein from Methanobacterium thermoauto (259 aa)%2C FASTA scores: opt: 173%2C E(): 5.2e-05%2C (32.7%25 identity in 214 aa overlap).;gbkey=CDS;locus_tag=Rv0318c;product=Probable conserved integral membrane protein;protein_id=CCP43048.1;transl_table=11
AL123456.3	EMBL	gene	387148	387816	.	+	.	ID=gene-Rv0319;Name=pcp;gbkey=Gene;gene=pcp;gene_biotype=protein_coding;locus_tag=Rv0319
AL123456.3	EMBL	CDS	387148	387816	.	+	0	ID=cds-CCP43049.1;Parent=gene-Rv0319;Dbxref=EnsemblGenomes-Gn:Rv0319,EnsemblGenomes-Tr:CCP43049,GOA:P9WIJ5,InterPro:IPR000816,InterPro:IPR016125,InterPro:IPR029762,NCBI_GP:CCP43049.1;Name=CCP43049.1;Note=Rv0319%2C (MTCY63.24)%2C len: 222 aa. Probable pcp%2Cpyrrolidone-carboxylate peptidase%2C highly similar to others e.g. PCP_PSEFL|P42673 pyrrolidone-carboxylate peptidase from Pseudomonas fluorescens (213 aa)%2C FASTA scores: opt: 478%2C E(): 7.5e-25%2C (40.2%25 identity in 219 aa overlap). Belongs to peptidase family C15 (thiol protease).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pcp;locus_tag=Rv0319;product=Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase);protein_id=CCP43049.1;transl_table=11
AL123456.3	EMBL	gene	387888	388550	.	+	.	ID=gene-Rv0320;Name=Rv0320;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0320
AL123456.3	EMBL	CDS	387888	388550	.	+	0	ID=cds-CCP43050.1;Parent=gene-Rv0320;Dbxref=EnsemblGenomes-Gn:Rv0320,EnsemblGenomes-Tr:CCP43050,UniProtKB/TrEMBL:O07246,NCBI_GP:CCP43050.1;Name=CCP43050.1;Note=Rv0320%2C (MTCY63.25)%2C len: 220 aa. Possible conserved exported protein%2C similar to some hypothetical proteins and to the middle part of a peptidase: NP_066789.1|10657900|AAG21739.1|AF116907 putative peptidase from Rhodococcus equi (546 aa). Also similar to Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256 aa)%2C FASTA scores: opt: 497%2C E(): 1.2e-26%2C (41.8%25 identity in 225 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv0320;product=Possible conserved exported protein;protein_id=CCP43050.1;transl_table=11
AL123456.3	EMBL	gene	388582	389154	.	+	.	ID=gene-Rv0321;Name=dcd;gbkey=Gene;gene=dcd;gene_biotype=protein_coding;gene_synonym=dus,paxA;locus_tag=Rv0321
AL123456.3	EMBL	CDS	388582	389154	.	+	0	ID=cds-CCP43051.1;Parent=gene-Rv0321;Dbxref=EnsemblGenomes-Gn:Rv0321,EnsemblGenomes-Tr:CCP43051,GOA:P9WP17,InterPro:IPR008180,InterPro:IPR011962,InterPro:IPR029054,PDB:2QLP,PDB:2QXX,PDB:4A6A,NCBI_GP:CCP43051.1;Name=CCP43051.1;Note=Rv0321%2C (MTCY63.26)%2C len: 190 aa. Probable dcd (alternate gene names: dus or paxA)%2C deoxycytidine triphosphate deaminase%2C equivalent to CAC32024.1|AL583925 probable deoxycytidine triphosphate deaminase from Mycobacterium leprae (190 aa). Also highly similar to others e.g. Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 deoxycytidine triphosphate deaminase from Streptomyces coelicolor (191 aa)%3B DCD_ECOLI|P28248|DUS|PAXA|B2065 deoxycytidine triphosphate deaminase from Escherichia coli strain K12 (193 aa)%2C FASTA scores: opt: 408%2C E(): 2.7e-21%2C(43.1%25 identity in 188 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the dCTP deaminase family. The transcription of this CDS seems to be activated specifically in host granulomas (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dcd;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0321;product=Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase);protein_id=CCP43051.1;transl_table=11
AL123456.3	EMBL	gene	389260	390591	.	+	.	ID=gene-Rv0322;Name=udgA;gbkey=Gene;gene=udgA;gene_biotype=protein_coding;gene_synonym=rkpK;locus_tag=Rv0322
AL123456.3	EMBL	CDS	389260	390591	.	+	0	ID=cds-CCP43052.1;Parent=gene-Rv0322;Dbxref=EnsemblGenomes-Gn:Rv0322,EnsemblGenomes-Tr:CCP43052,GOA:O07248,InterPro:IPR001732,InterPro:IPR008927,InterPro:IPR014026,InterPro:IPR014027,InterPro:IPR016040,InterPro:IPR017476,InterPro:IPR028357,UniProtKB/TrEMBL:O07248,NCBI_GP:CCP43052.1;Name=CCP43052.1;Note=Rv0322%2C (MTCY63.27)%2C len: 443 aa. Probable udg (alternate gene name: rkpK)%2C UDP-glucose 6-dehydrogenase %2Chighly similar to others e.g. CAC44517.1|AL596138 putative UDP-glucose 6-dehydrogenase from Streptomyces coelicolor (447 aa)%3B Q56812 UDP-glucose dehydrogenase from Xanthomonas campestris (445 aa)%2C FASTA scores: opt: 713%2C E(): 0%2C (41.9%25 identity in 351 aa overlap)%3B etc. Also similar to several GDP-mannose 6-dehydrogenase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the UDP-glucose/GDP-mannose dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=udgA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0322;product=Probable UDP-glucose 6-dehydrogenase UdgA (UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH);protein_id=CCP43052.1;transl_table=11
AL123456.3	EMBL	gene	390580	391251	.	-	.	ID=gene-Rv0323c;Name=Rv0323c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0323c
AL123456.3	EMBL	CDS	390580	391251	.	-	0	ID=cds-CCP43053.1;Parent=gene-Rv0323c;Dbxref=EnsemblGenomes-Gn:Rv0323c,EnsemblGenomes-Tr:CCP43053,InterPro:IPR003737,InterPro:IPR024078,UniProtKB/TrEMBL:L0T643,NCBI_GP:CCP43053.1;Name=CCP43053.1;Note=Rv0323c%2C (MTCY63.28c)%2C len: 223 aa. Conserved hypothetical protein%2C similar to others e.g. YPJG_BACSU|P42981 hypothetical 24.8 kDa protein from Bacillus subtilis (224 aa)%2C FASTA scores: opt: 182%2C E(): 1.3e-05%2C (27.5%25 identity in 211 aa overlap). Also some similarity to MLU15183_8 from Mycobacterium tuberculosis FASTA score: (32.0%25 identity in 147 aa overlap). Alternative nucleotide at position 390828 (T->C%3B S142G) has been observed. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0323c;product=Conserved hypothetical protein;protein_id=CCP43053.1;transl_table=11
AL123456.3	EMBL	gene	391352	392032	.	+	.	ID=gene-Rv0324;Name=Rv0324;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0324
AL123456.3	EMBL	CDS	391352	392032	.	+	0	ID=cds-CCP43054.1;Parent=gene-Rv0324;Dbxref=EnsemblGenomes-Gn:Rv0324,EnsemblGenomes-Tr:CCP43054,GOA:O08446,InterPro:IPR001307,InterPro:IPR001763,InterPro:IPR001845,InterPro:IPR011991,UniProtKB/TrEMBL:O08446,NCBI_GP:CCP43054.1;Name=CCP43054.1;Note=Rv0324%2C (MTCY63.29)%2C len: 226 aa. Possible transcriptional regulator%2C arsR family%2C with its N-terminus similar to the N-terminus of other DNA-binding proteins e.g. P30346|MERR_STRLI probable mercury resistance operon from Streptomyces lividans (125 aa)%2C FASTA scores: opt: 154%2C E(): 0.002%2C (32.2%25 identity in 90 aa overlap)%2C and its C-terminal part similar to hypothetical bacterial proteins e.g. P54510|YQHL_BACSU hypothetical 14.6 kDa protein from Bacillus subtilis (126 aa)%2C FASTA scores: opt: 159%2C E(): 0.00097%2C (35.5%25 identity in 76 aa overlap). Most similar to AJ005575|SPE005575_2 ORF1 required for antibiotic production from Streptomyces peucetius (226 aa)%2C FASTA scores: opt: 816%2C E(): 0%2C (60.7%25 identity in 211 aa overlap). Also similar in C-terminus to MTCY164.26 molybdopterin biosynthesis moeb protein from Mycobacterium tuberculosis FASTA score: (36.8%25 identity in 114 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0324;product=Possible transcriptional regulatory protein (possibly ArsR-family);protein_id=CCP43054.1;transl_table=11
AL123456.3	EMBL	gene	392039	392263	.	+	.	ID=gene-Rv0325;Name=Rv0325;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0325
AL123456.3	EMBL	CDS	392039	392263	.	+	0	ID=cds-CCP43055.1;Parent=gene-Rv0325;Dbxref=EnsemblGenomes-Gn:Rv0325,EnsemblGenomes-Tr:CCP43055,GOA:O07250,UniProtKB/TrEMBL:O07250,NCBI_GP:CCP43055.1;Name=CCP43055.1;Note=Rv0325%2C (MTCY63.30)%2C len: 74 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0325;product=Hypothetical protein;protein_id=CCP43055.1;transl_table=11
AL123456.3	EMBL	gene	392273	392728	.	+	.	ID=gene-Rv0326;Name=Rv0326;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0326
AL123456.3	EMBL	CDS	392273	392728	.	+	0	ID=cds-CCP43056.1;Parent=gene-Rv0326;Dbxref=EnsemblGenomes-Gn:Rv0326,EnsemblGenomes-Tr:CCP43056,GOA:O07251,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:O07251,NCBI_GP:CCP43056.1;Name=CCP43056.1;Note=Rv0326%2C (MTCY63.31)%2C len: 151 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0326;product=Hypothetical protein;protein_id=CCP43056.1;transl_table=11
AL123456.3	EMBL	gene	392696	394045	.	-	.	ID=gene-Rv0327c;Name=cyp135A1;gbkey=Gene;gene=cyp135A1;gene_biotype=protein_coding;locus_tag=Rv0327c
AL123456.3	EMBL	CDS	392696	394045	.	-	0	ID=cds-CCP43057.1;Parent=gene-Rv0327c;Dbxref=EnsemblGenomes-Gn:Rv0327c,EnsemblGenomes-Tr:CCP43057,GOA:P9WPN1,InterPro:IPR001128,InterPro:IPR002401,InterPro:IPR017972,NCBI_GP:CCP43057.1;Name=CCP43057.1;Note=Rv0327c%2C (MT0342%2C MTCY63.32c)%2C len: 449 aa. Possible cyp135A1%2C cytochrome P450%2C similar to cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. FQ12609 putative P450 monooxygenase (506 aa)%2C FASTA scores: opt: 276%2C E() : 1.7e-11%2C (27.9%25 identity in 433 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. MTV039.06|Rv0568 putative cytochrome P450 (472 aa)%3B MTCI5.10 cytochrome p450 FASTA score: (30.4%25 identity in 434 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). Belongs to the cytochrome P450 family. Alternative start possible at 33706 but no RBS. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=cyp135A1;inference=protein motif:PROSITE:PS00086;locus_tag=Rv0327c;product=Possible cytochrome P450 135A1 Cyp135A1;protein_id=CCP43057.1;transl_table=11
AL123456.3	EMBL	gene	394111	394713	.	+	.	ID=gene-Rv0328;Name=Rv0328;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0328
AL123456.3	EMBL	CDS	394111	394713	.	+	0	ID=cds-CCP43058.1;Parent=gene-Rv0328;Dbxref=EnsemblGenomes-Gn:Rv0328,EnsemblGenomes-Tr:CCP43058,GOA:O07252,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O07252,NCBI_GP:CCP43058.1;Name=CCP43058.1;Note=Rv0328%2C (MTCY63.33)%2C len: 200 aa. Possible transcription regulator%2C TetR/acrR family%2C similar in part to various hypothetical transcriptional regulators e.g. T36696|4726006|CAB41735.1|AL049731 probable regulatory protein from Streptomyces coelicolor (197 aa). Also some similarity with YX44_MYCTU|Q10829 hypothetical transcriptional regulator from Mycobacterium tuberculosis (195 aa)%2C FASTA scores: opt: 154%2C E(): 0.00061%2C (26.7%25 identity in 202 aa overlap). Contains probable helix-turn helix motif from aa 27-48 (Score 1408%2C +3.98 SD). Seems to belong to the TetR/AcrR family of transcriptional regulators. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0328;product=Possible transcriptional regulatory protein (possibly TetR/AcrR-family);protein_id=CCP43058.1;transl_table=11
AL123456.3	EMBL	gene	394694	395320	.	-	.	ID=gene-Rv0329c;Name=Rv0329c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0329c
AL123456.3	EMBL	CDS	394694	395320	.	-	0	ID=cds-CCP43059.1;Parent=gene-Rv0329c;Dbxref=EnsemblGenomes-Gn:Rv0329c,EnsemblGenomes-Tr:CCP43059,GOA:O07253,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:O07253,NCBI_GP:CCP43059.1;Name=CCP43059.1;Note=Rv0329c%2C (MTCY63.34c)%2C len: 208 aa. Conserved hypothetical protein%2C showing some similarity with others hypothetical proteins and methyltransferases e.g. MitM|AF127374_14 methyltransferase from Streptomyces lavendulae (283 aa)%2C FASTA scores: opt: 242%2C E(): 1.8e-08%2C(37.2%25 identity in 145 aa overlap)%3B Q48938 from Methanosarcina barkeri (262 aa)%2C FASTA scores: opt: 194%2CE(): 3.6e-06%2C (31.1%25 identity in 119 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0329c;product=Conserved hypothetical protein;protein_id=CCP43059.1;transl_table=11
AL123456.3	EMBL	gene	395347	396087	.	-	.	ID=gene-Rv0330c;Name=Rv0330c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0330c
AL123456.3	EMBL	CDS	395347	396087	.	-	0	ID=cds-CCP43060.1;Parent=gene-Rv0330c;Dbxref=EnsemblGenomes-Gn:Rv0330c,EnsemblGenomes-Tr:CCP43060,GOA:O07254,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:O07254,NCBI_GP:CCP43060.1;Name=CCP43060.1;Note=Rv0330c%2C (MTCY63.35c)%2C len: 246 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0330c;product=Hypothetical protein;protein_id=CCP43060.1;transl_table=11
AL123456.3	EMBL	gene	396201	397367	.	+	.	ID=gene-Rv0331;Name=Rv0331;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0331
AL123456.3	EMBL	CDS	396201	397367	.	+	0	ID=cds-CCP43061.1;Parent=gene-Rv0331;Dbxref=EnsemblGenomes-Gn:Rv0331,EnsemblGenomes-Tr:CCP43061,GOA:O07255,InterPro:IPR013027,InterPro:IPR023753,UniProtKB/TrEMBL:O07255,NCBI_GP:CCP43061.1;Name=CCP43061.1;Note=Rv0331%2C (MTCY63.36)%2C len: 388 aa. Possible dehydrogenase/reductase%2C similar to various dehydrogenases/reductases e.g. NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein reductase from Mesorhizobium loti (377 aa)%3B NP_147681.1 predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum pernix (381 aa)%3B DHSU_CHRVI|Q06530 sulfide dehydrogenase (431 aa)%2C FASTA scores: opt: 347%2C E(): 6.8e-15%2C (25.6%25 identity in 348 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0331;product=Possible dehydrogenase/reductase;protein_id=CCP43061.1;transl_table=11
AL123456.3	EMBL	gene	397442	398227	.	+	.	ID=gene-Rv0332;Name=Rv0332;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0332
AL123456.3	EMBL	CDS	397442	398227	.	+	0	ID=cds-CCP43062.1;Parent=gene-Rv0332;Dbxref=EnsemblGenomes-Gn:Rv0332,EnsemblGenomes-Tr:CCP43062,GOA:O07256,InterPro:IPR010872,InterPro:IPR017517,InterPro:IPR024344,UniProtKB/TrEMBL:O07256,NCBI_GP:CCP43062.1;Name=CCP43062.1;Note=Rv0332%2C (MTCY63.37)%2C len: 261 aa. Conserved protein%2Csimilar to several conserved hypothetical proteins from Streptomyces coelicolor e.g. SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein (266 aa)%2C FASTA scores: opt: 508%2C E(): 5.7e-27%2C (36.7%25 identity in 251 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0332;product=Conserved protein;protein_id=CCP43062.1;transl_table=11
AL123456.3	EMBL	gene	398254	398628	.	+	.	ID=gene-Rv0333;Name=Rv0333;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0333
AL123456.3	EMBL	CDS	398254	398628	.	+	0	ID=cds-CCP43063.1;Parent=gene-Rv0333;Dbxref=EnsemblGenomes-Gn:Rv0333,EnsemblGenomes-Tr:CCP43063,InterPro:IPR009959,UniProtKB/TrEMBL:O33273,NCBI_GP:CCP43063.1;Name=CCP43063.1;Note=Rv0333%2C (MTCY63.38)%2C len: 124 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0333;product=Unknown protein;protein_id=CCP43063.1;transl_table=11
AL123456.3	EMBL	gene	398658	399524	.	+	.	ID=gene-Rv0334;Name=rmlA;gbkey=Gene;gene=rmlA;gene_biotype=protein_coding;gene_synonym=rfbA;locus_tag=Rv0334
AL123456.3	EMBL	CDS	398658	399524	.	+	0	ID=cds-CCP43064.1;Parent=gene-Rv0334;Dbxref=EnsemblGenomes-Gn:Rv0334,EnsemblGenomes-Tr:CCP43064,GOA:P9WH13,InterPro:IPR005835,InterPro:IPR005907,InterPro:IPR029044,NCBI_GP:CCP43064.1;Name=CCP43064.1;Note=Rv0334%2C (MTCY279.01)%2C len: 288 aa. RmlA (alternate gene name: rfbA)%2C alpha-D-glucose-1-phosphate thymidylyl-transferase (see citations below)%2C equivalent to CAC32020.1|AL583925 glucose-1-phosphate thymidyltransferase from Mycobacterium leprae (288 aa). Also highly similar to others e.g. AAG29804.1|AF235050 glucose-1-phosphate thymidylyltransferase from Streptomyces rishiriensis (296 aa)%3B RBA1_ECOLI|P37744 glucose-1-phosphate thymidylyltransferase from Escherichia coli strain K12 (293 aa)%2C FASTA scores: opt: 1199%2C E(): 0%2C (62.0%25 identity in 284 aa overlap). Belongs to the glucose-1-phosphate thymidylyltransferase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rmlA;locus_tag=Rv0334;product=Alpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) (dTDP-glucose pyrophosphorylase);protein_id=CCP43064.1;transl_table=11
AL123456.3	EMBL	gene	399535	400050	.	-	.	ID=gene-Rv0335c;Name=PE6;gbkey=Gene;gene=PE6;gene_biotype=protein_coding;locus_tag=Rv0335c
AL123456.3	EMBL	CDS	399535	400050	.	-	0	ID=cds-CCP43065.1;Parent=gene-Rv0335c;Dbxref=EnsemblGenomes-Gn:Rv0335c,EnsemblGenomes-Tr:CCP43065,InterPro:IPR000084,UniProtKB/TrEMBL:L7N648,NCBI_GP:CCP43065.1;Name=CCP43065.1;Note=Rv0335c%2C (MTCY279.02c)%2C len: 171 aa. PE6%2C Member of the Mycobacterium tuberculosis PE family (see Brennan %26 Delogu 2002)%3B contains short region of similarity to part of the unique N-terminus of the Mycobacterium tuberculosis PGRS family of Glycine-rich proteins e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa)%2C FASTA scores: opt: 219%2C E(): 1.1e-08%2C (51.5%25 identity in 66 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE6;locus_tag=Rv0335c;product=PE family protein PE6;protein_id=CCP43065.1;transl_table=11
AL123456.3	EMBL	gene	400192	401703	.	+	.	ID=gene-Rv0336;Name=Rv0336;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0336
AL123456.3	EMBL	CDS	400192	401703	.	+	0	ID=cds-CCP43066.1;Parent=gene-Rv0336;Dbxref=EnsemblGenomes-Gn:Rv0336,EnsemblGenomes-Tr:CCP43066,GOA:O33266,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:O33266,NCBI_GP:CCP43066.1;Name=CCP43066.1;Note=Rv0336%2C (MTCY279.03)%2C len: 503 aa. Part of Mycobacterium tuberculosis 13E12 repeat family%3B almost identical to Rv0515|MTCY20G10.05 hypothetical protein from Mycobacterium tuberculosis FASTA scores: (99.8%25 identity in 503 aa overlap)%2C possibly due to a recent gene duplication. Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1148c%2C Rv1945%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0336;product=Conserved 13E12 repeat family protein;protein_id=CCP43066.1;transl_table=11
AL123456.3	EMBL	gene	401873	403162	.	-	.	ID=gene-Rv0337c;Name=aspC;gbkey=Gene;gene=aspC;gene_biotype=protein_coding;locus_tag=Rv0337c
AL123456.3	EMBL	CDS	401873	403162	.	-	0	ID=cds-CCP43067.1;Parent=gene-Rv0337c;Dbxref=EnsemblGenomes-Gn:Rv0337c,EnsemblGenomes-Tr:CCP43067,GOA:P9WQ91,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP43067.1;Name=CCP43067.1;Note=Rv0337c%2C (MTCY279.04c)%2C len: 429 aa. Probable aspC%2Caspartate aminotransferase (transaminase A)%2C equivalent to CAC32019.1|AL583925 probable aspartate aminotransferase from Mycobacterium leprae (437 aa). Also highly similar to many e.g. Q48143|U32823 aspartate aminotransferase (404 aa)%2C FASTA scores: opt: 1646%2C E(): 0%2C (57.2%25 identity in 404 aa overlap). Also some similarity to Rv3565|MTCY06G11.12 from Mycobacterium tuberculosis FASTA score: (27.2%25 identity in 383 aa overlap). Belongs to class-I of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aspC;locus_tag=Rv0337c;product=Probable aspartate aminotransferase AspC (transaminase A) (ASPAT);protein_id=CCP43067.1;transl_table=11
AL123456.3	EMBL	gene	403193	405841	.	-	.	ID=gene-Rv0338c;Name=Rv0338c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0338c
AL123456.3	EMBL	CDS	403193	405841	.	-	0	ID=cds-CCP43068.1;Parent=gene-Rv0338c;Dbxref=EnsemblGenomes-Gn:Rv0338c,EnsemblGenomes-Tr:CCP43068,GOA:O33268,InterPro:IPR004017,InterPro:IPR009051,InterPro:IPR017896,InterPro:IPR017900,UniProtKB/TrEMBL:O33268,NCBI_GP:CCP43068.1;Name=CCP43068.1;Note=Rv0338c%2C (MTCY279.05c)%2C len: 882 aa. Probable iron-sulphur-binding reductase%2C possibly membrane-bound%2Cequivalent to CAC32018.1|AL583925 probable iron-sulphur-binding reductase from Mycobacterium leprae (880 aa). Also highly similar to others e.g. T36608|5019323|CAB44376.1|AL078610 probable iron-sulfur-binding reductase from Streptomyces coelicolor (760 aa)%2C FASTA scores: opt: 1658%2C E(): 0%2C (49.9%25 identity in 772 aa overlap)%3B BAB07521.1|AP001520 iron-sulphur-binding reductase from Bacillus halodurans (700 aa). Contains PS00070 Aldehyde dehydrogenases cysteine active site and two of PS00198 4Fe-4S ferredoxins%2Ciron-sulfur binding region signature. First of several possible start sites chosen.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00198;locus_tag=Rv0338c;product=Probable iron-sulfur-binding reductase;protein_id=CCP43068.1;transl_table=11
AL123456.3	EMBL	gene	405950	408448	.	-	.	ID=gene-Rv0339c;Name=Rv0339c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0339c
AL123456.3	EMBL	CDS	405950	408448	.	-	0	ID=cds-CCP43069.1;Parent=gene-Rv0339c;Dbxref=EnsemblGenomes-Gn:Rv0339c,EnsemblGenomes-Tr:CCP43069,GOA:O33269,InterPro:IPR000792,InterPro:IPR011991,InterPro:IPR016032,InterPro:IPR027417,UniProtKB/TrEMBL:O33269,NCBI_GP:CCP43069.1;Name=CCP43069.1;Note=Rv0339c%2C (MTCY279.06c)%2C len: 832 aa. Possible transcriptional regulator%2C showing very weak similarity with parts of others. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%3B and probable helix-turn helix motif from aa 778-799 (Score 1041%2C +2.73 SD).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0339c;product=Possible transcriptional regulatory protein;protein_id=CCP43069.1;transl_table=11
AL123456.3	EMBL	gene	408634	409173	.	+	.	ID=gene-Rv0340;Name=Rv0340;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0340
AL123456.3	EMBL	CDS	408634	409173	.	+	0	ID=cds-CCP43070.1;Parent=gene-Rv0340;Dbxref=EnsemblGenomes-Gn:Rv0340,EnsemblGenomes-Tr:CCP43070,GOA:O33270,UniProtKB/TrEMBL:O33270,NCBI_GP:CCP43070.1;Name=CCP43070.1;Note=Rv0340%2C (MTCY279.07)%2C len: 179 aa. Conserved protein%3B MEME-mast analysis shows similarity to product of downstream gene%2C Rv0341|iniB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0340;product=Conserved protein;protein_id=CCP43070.1;transl_table=11
AL123456.3	EMBL	gene	409362	410801	.	+	.	ID=gene-Rv0341;Name=iniB;gbkey=Gene;gene=iniB;gene_biotype=protein_coding;locus_tag=Rv0341
AL123456.3	EMBL	CDS	409362	410801	.	+	0	ID=cds-CCP43071.1;Parent=gene-Rv0341;Dbxref=EnsemblGenomes-Gn:Rv0341,EnsemblGenomes-Tr:CCP43071,NCBI_GP:CCP43071.1;Name=CCP43071.1;Note=Rv0341%2C (MTCY13E10.01)%2C len: 479 aa. IniB%2Cisoniazid-inducible gene%2C (see citations below). Protein very Gly-%2C Ala-rich%2C similar to cell wall proteins e.g. P27483|GRP_ARATH glycine-rich cell wall structural protein from A.thaliana (338 aa)%2C FASTA scores: opt: 532%2C E(): 5.2e-13%2C (39.3%25 identity in 321 aa overlap). MEME-mast analysis shows similarity to product of upstream gene%2CRv0340.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=iniB;locus_tag=Rv0341;product=Isoniazid inductible gene protein IniB;protein_id=CCP43071.1;transl_table=11
AL123456.3	EMBL	gene	410838	412760	.	+	.	ID=gene-Rv0342;Name=iniA;gbkey=Gene;gene=iniA;gene_biotype=protein_coding;locus_tag=Rv0342
AL123456.3	EMBL	CDS	410838	412760	.	+	0	ID=cds-CCP43072.1;Parent=gene-Rv0342;Dbxref=EnsemblGenomes-Gn:Rv0342,EnsemblGenomes-Tr:CCP43072,GOA:P9WJ99,InterPro:IPR001401,InterPro:IPR027417,NCBI_GP:CCP43072.1;Name=CCP43072.1;Note=Rv0342%2C iniA%2C (MTCY13E10.02)%2C len: 640 aa. IniA%2Cisoniazid-inducible gene%2C (see citations below). Shows slight similarity to some hypothetical bacterial proteins e.g. P40983|YOR6_THER hypothetical protein (402 aa)%2C FASTA scores: opt: 242%2C E(): 1.4e-07%2C (22.3%25 identity in 349 aa overlap). Also some similarity to downstream ORF Rv0343|iniC. Possible transmembrane stretch around residue 490. Alternative start site exists at 410824. Contains a phosphopantetheine attachment site motif suggestive of an acyl carrier protein. Note that the iniA gene is also induced by the antibiotic ethambutol%2C an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=iniA;locus_tag=Rv0342;product=Isoniazid inductible gene protein IniA;protein_id=CCP43072.1;transl_table=11
AL123456.3	EMBL	gene	412757	414238	.	+	.	ID=gene-Rv0343;Name=iniC;gbkey=Gene;gene=iniC;gene_biotype=protein_coding;locus_tag=Rv0343
AL123456.3	EMBL	CDS	412757	414238	.	+	0	ID=cds-CCP43073.1;Parent=gene-Rv0343;Dbxref=EnsemblGenomes-Gn:Rv0343,EnsemblGenomes-Tr:CCP43073,GOA:P9WJ95,InterPro:IPR001401,InterPro:IPR027417,NCBI_GP:CCP43073.1;Name=CCP43073.1;Note=Rv0343%2C (MTCY13E10.03)%2C len: 493 aa. IniC%2Cisoniazid-inducible gene%2C (see citations below). Shows slight similarity to P40983|YOR6_THER8 hypothetical protein (402 aa)%2C FASTA scores: opt: 196%2C E(): 2.6e-05%2C (25.9%25 identity in 228 aa overlap). Also some similarity to upstream ORF Rv0342|iniA. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). Note that the iniA gene is also induced by the antibiotic ethambutol%2C an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=iniC;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0343;product=Isoniazid inductible gene protein IniC;protein_id=CCP43073.1;transl_table=11
AL123456.3	EMBL	gene	414381	414941	.	-	.	ID=gene-Rv0344c;Name=lpqJ;gbkey=Gene;gene=lpqJ;gene_biotype=protein_coding;locus_tag=Rv0344c
AL123456.3	EMBL	CDS	414381	414941	.	-	0	ID=cds-CCP43074.1;Parent=gene-Rv0344c;Dbxref=EnsemblGenomes-Gn:Rv0344c,EnsemblGenomes-Tr:CCP43074,UniProtKB/TrEMBL:O06295,NCBI_GP:CCP43074.1;Name=CCP43074.1;Note=Rv0344c%2C (MTCY13E10.04c)%2C len: 186 aa. Probable lipoprotein%2C without homology. Has an appropriately positioned prokaryotic lipoprotein signature (PS00013).;gbkey=CDS;gene=lpqJ;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0344c;product=Probable lipoprotein LpqJ;protein_id=CCP43074.1;transl_table=11
AL123456.3	EMBL	gene	415050	415460	.	+	.	ID=gene-Rv0345;Name=Rv0345;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0345
AL123456.3	EMBL	CDS	415050	415460	.	+	0	ID=cds-CCP43075.1;Parent=gene-Rv0345;Dbxref=EnsemblGenomes-Gn:Rv0345,EnsemblGenomes-Tr:CCP43075,InterPro:IPR025877,InterPro:IPR029044,UniProtKB/TrEMBL:O06296,NCBI_GP:CCP43075.1;Name=CCP43075.1;Note=Rv0345%2C (MTCY13E10.05)%2C len: 136 aa. Conserved hypothetical protein%2C similar to other hypothetical proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from Streptomyces coelicolor (207 aa)%2C FASTA scores: opt: 188%2CE(): 1.5e-05%2C (41.0%25 identity in 117 aa overlap).;gbkey=CDS;locus_tag=Rv0345;product=Conserved hypothetical protein;protein_id=CCP43075.1;transl_table=11
AL123456.3	EMBL	gene	415502	416965	.	-	.	ID=gene-Rv0346c;Name=ansP2;gbkey=Gene;gene=ansP2;gene_biotype=protein_coding;gene_synonym=aroP2;locus_tag=Rv0346c
AL123456.3	EMBL	CDS	415502	416965	.	-	0	ID=cds-CCP43076.1;Parent=gene-Rv0346c;Dbxref=EnsemblGenomes-Gn:Rv0346c,EnsemblGenomes-Tr:CCP43076,GOA:P9WQM7,InterPro:IPR002293,InterPro:IPR004840,InterPro:IPR004841,NCBI_GP:CCP43076.1;Name=CCP43076.1;Note=Rv0346c%2C (MTCY13E10.06c)%2C len: 487 aa. Possible ansP2%2C L-asparagine permease%2C integral membrane protein belonging to family containing many amino acid permeases%2Chighly similar to G467030|B2126_F2_85|NP_301937.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (498 aa)%3B and NP_301938.1|NC_002677 probable L-asparagine permease from Mycobacterium leprae (505 aa). Also highly similar to others e.g. P77610|ANSP_ECOLI L-asparagine permease from Escherichia coli strain K-12 (499 aa). Also highly similar to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 probable L-asparagine permease from Mycobacterium tuberculosis (489 aa)%2C FASTA score: (72.1%25 identity in 473 aa overlap). And shows some similarity to MTCY3G12.14 from Mycobacterium tuberculosis. Belongs to the amino acid permease family (APC family). Note that previously known as aroP2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ansP2;locus_tag=Rv0346c;product=Possible L-asparagine permease AnsP2 (L-asparagine transport protein);protein_id=CCP43076.1;transl_table=11
AL123456.3	EMBL	gene	417304	418290	.	+	.	ID=gene-Rv0347;Name=Rv0347;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0347
AL123456.3	EMBL	CDS	417304	418290	.	+	0	ID=cds-CCP43077.1;Parent=gene-Rv0347;Dbxref=EnsemblGenomes-Gn:Rv0347,EnsemblGenomes-Tr:CCP43077,GOA:O06298,InterPro:IPR026349,UniProtKB/TrEMBL:O06298,NCBI_GP:CCP43077.1;Name=CCP43077.1;Note=Rv0347%2C (MTCY13E10.07)%2C len: 328 aa (alternative start possible). Probable conserved membrane protein%2Csimilar to Rv0831c|AL022004|MTV043_23 from Mycobacterium tuberculosis (271 aa)%2C FASTA scores: E(): 9.6e-21%2C (33.1%25 identity in 266 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0347;product=Probable conserved membrane protein;protein_id=CCP43077.1;transl_table=11
AL123456.3	EMBL	gene	418293	418946	.	+	.	ID=gene-Rv0348;Name=Rv0348;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0348
AL123456.3	EMBL	CDS	418293	418946	.	+	0	ID=cds-CCP43078.1;Parent=gene-Rv0348;Dbxref=EnsemblGenomes-Gn:Rv0348,EnsemblGenomes-Tr:CCP43078,UniProtKB/TrEMBL:O06299,NCBI_GP:CCP43078.1;Name=CCP43078.1;Note=Rv0348%2C (MTCY13E10.08)%2C len: 217 aa. Possible transcriptional regulator%2C showing some similarity to O53334|RV3188|MTV014.32 conserved hypothetical protein from Mycobacterium tuberculosis (115 aa)%2C FASTA score: (30.0%25 identity in 100 aa overlap). Contains probable helix-turn helix motif from aa 89-110 (Score 1407%2C +3.98 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0348;product=Possible transcriptional regulatory protein;protein_id=CCP43078.1;transl_table=11
AL123456.3	EMBL	gene	418949	419608	.	+	.	ID=gene-Rv0349;Name=Rv0349;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0349
AL123456.3	EMBL	CDS	418949	419608	.	+	0	ID=cds-CCP43079.1;Parent=gene-Rv0349;Dbxref=EnsemblGenomes-Gn:Rv0349,EnsemblGenomes-Tr:CCP43079,UniProtKB/TrEMBL:O06300,NCBI_GP:CCP43079.1;Name=CCP43079.1;Note=Rv0349%2C (MTCY13E10.09)%2C len: 219 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0349;product=Hypothetical protein;protein_id=CCP43079.1;transl_table=11
AL123456.3	EMBL	gene	419835	421712	.	+	.	ID=gene-Rv0350;Name=dnaK;gbkey=Gene;gene=dnaK;gene_biotype=protein_coding;gene_synonym=hsp70;locus_tag=Rv0350
AL123456.3	EMBL	CDS	419835	421712	.	+	0	ID=cds-CCP43080.1;Parent=gene-Rv0350;Dbxref=EnsemblGenomes-Gn:Rv0350,EnsemblGenomes-Tr:CCP43080,GOA:P9WMJ9,InterPro:IPR012725,InterPro:IPR013126,InterPro:IPR018181,InterPro:IPR029047,InterPro:IPR029048,NCBI_GP:CCP43080.1;Name=CCP43080.1;Note=Rv0350%2C (MTCY13E10.10)%2C len: 625 aa. Probable dnaK (alternate gene name: hsp70)%2C 70 kDa heat shock protein (see citations below)%2C equivalent to AAA25362.1|M95576|1924344A|738248 heat shock protein 70 from Mycobacterium leprae (621 aa)%3B and DNAK_MYCPA|Q00488 (623 aa)%2C FASTA scores: opt: 3678%2C E(): 0%2C (92.3%25 identity in 625 aa overlap). Also highly similar to others e.g. Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 chaperone protein DNAK from Streptomyces coelicolor (618 aa). Has probably an ATPase activity. Note that this sequence differs from DNAK_MYCTU|P32723 (609 aa)%2C due to a frameshift near the N-terminus. Belongs to the heat shock protein 70 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaK;locus_tag=Rv0350;product=Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70);protein_id=CCP43080.1;transl_table=11
AL123456.3	EMBL	gene	421709	422416	.	+	.	ID=gene-Rv0351;Name=grpE;gbkey=Gene;gene=grpE;gene_biotype=protein_coding;locus_tag=Rv0351
AL123456.3	EMBL	CDS	421709	422416	.	+	0	ID=cds-CCP43081.1;Parent=gene-Rv0351;Dbxref=EnsemblGenomes-Gn:Rv0351,EnsemblGenomes-Tr:CCP43081,GOA:P9WMT5,InterPro:IPR000740,InterPro:IPR009012,InterPro:IPR013805,NCBI_GP:CCP43081.1;Name=CCP43081.1;Note=Rv0351%2C (MTCY13E10.11)%2C len: 235 aa. Probable grpE protein (HSP-70 cofactor)%2C equivalent to CAC32012.1|AL583925 Hsp70 cofactor from Mycobacterium leprae (229 aa). Also highly similar to others eg Q05562|GRPE_STRCO|2127521|PN0643 GRPE protein from Streptomyces coelicolor (225 aa). Contains grpE protein signature (PS01071). Belongs to the GrpE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=grpE;inference=protein motif:PROSITE:PS01071;locus_tag=Rv0351;product=Probable GrpE protein (HSP-70 cofactor);protein_id=CCP43081.1;transl_table=11
AL123456.3	EMBL	gene	422452	423639	.	+	.	ID=gene-Rv0352;Name=dnaJ1;gbkey=Gene;gene=dnaJ1;gene_biotype=protein_coding;gene_synonym=dnaJ;locus_tag=Rv0352
AL123456.3	EMBL	CDS	422452	423639	.	+	0	ID=cds-CCP43082.1;Parent=gene-Rv0352;Dbxref=EnsemblGenomes-Gn:Rv0352,EnsemblGenomes-Tr:CCP43082,GOA:P9WNV9,InterPro:IPR001305,InterPro:IPR001623,InterPro:IPR002939,InterPro:IPR008971,InterPro:IPR012724,InterPro:IPR018253,NCBI_GP:CCP43082.1;Name=CCP43082.1;Note=Rv0352%2C (MTCY13E10.12)%2C len: 395 aa. Probable dnaJ1%2Cchaperone protein%2C equivalent to AAA25363.1|M95576 DNA J heatshock protein from Mycobacterium leprae (389 aa). Also highly similar to others. Contains both DnaJ signatures (PS00636%2C and PS00637). Belongs to the DNAJ family. Cofactor: binds two zinc ions per monomer. Note that sequence differs from DNAJ_MYCTU|P07881 due to a frameshift at the N-terminus. Note that previously known as dnaJ.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaJ1;inference=protein motif:PROSITE:PS00637;locus_tag=Rv0352;product=Probable chaperone protein DnaJ1;protein_id=CCP43082.1;transl_table=11
AL123456.3	EMBL	gene	423639	424019	.	+	.	ID=gene-Rv0353;Name=hspR;gbkey=Gene;gene=hspR;gene_biotype=protein_coding;locus_tag=Rv0353
AL123456.3	EMBL	CDS	423639	424019	.	+	0	ID=cds-CCP43083.1;Parent=gene-Rv0353;Dbxref=EnsemblGenomes-Gn:Rv0353,EnsemblGenomes-Tr:CCP43083,GOA:O06302,InterPro:IPR000551,InterPro:IPR009061,UniProtKB/TrEMBL:O06302,NCBI_GP:CCP43083.1;Name=CCP43083.1;Note=Rv0353%2C (MTCY13E10.13)%2C len: 126 aa. Probable hspR%2Cheat shock regulatory protein (see Stewart et al.%2C 2001)%2CmerR family%2C highly similar to others e.g. HspR|P40183 heat shock regulatory protein from Streptomyces coelicolor (151 aa)%2C FASTA scores: E(): 4.9e-22%2C (55.7%25 identity in 140 aa overlap)%2C that binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon. Has possible coiled coil region in C-terminal half. Belongs to the MerR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hspR;locus_tag=Rv0353;product=Probable heat shock protein transcriptional repressor HspR (MerR family);protein_id=CCP43083.1;transl_table=11
AL123456.3	EMBL	gene	424269	424694	.	-	.	ID=gene-Rv0354c;Name=PPE7;gbkey=Gene;gene=PPE7;gene_biotype=protein_coding;locus_tag=Rv0354c
AL123456.3	EMBL	CDS	424269	424694	.	-	0	ID=cds-CCP43084.1;Parent=gene-Rv0354c;Dbxref=EnsemblGenomes-Gn:Rv0354c,EnsemblGenomes-Tr:CCP43084,UniProtKB/TrEMBL:L0T545,NCBI_GP:CCP43084.1;Name=CCP43084.1;Note=Rv0354c%2C (MTCY13E10.14c)%2C len: 141 aa. PPE7%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa)%2C FASTA scores: E(): 3.6e-11%2C (47.6%25 identity in 103 aa overlap). Possible continuation of ORF upstream%2C but no sequence error apparent.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE7;locus_tag=Rv0354c;product=PPE family protein PPE7;protein_id=CCP43084.1;transl_table=11
AL123456.3	EMBL	gene	424777	434679	.	-	.	ID=gene-Rv0355c;Name=PPE8;gbkey=Gene;gene=PPE8;gene_biotype=protein_coding;locus_tag=Rv0355c
AL123456.3	EMBL	CDS	424777	434679	.	-	0	ID=cds-CCP43085.1;Parent=gene-Rv0355c;Dbxref=EnsemblGenomes-Gn:Rv0355c,EnsemblGenomes-Tr:CCP43085,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:I6Y7L4,NCBI_GP:CCP43085.1;Name=CCP43085.1;Note=Rv0355c%2C (MTCY13E10.15c%2C MTCY13E10.16c%2CMTCY13E10.17c)%2C len: 3300 aa. PPE8%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to others e.g. AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 aa)%2C FASTA scores: opt: 2906%2C E(): 0%2C (40.9%25 identity in 3833 aa overlap)%3B MTV004_3 FASTA scores: (39.0%25 identity in 3531 aa overlap)%3B etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c%2C E(): 0%3B MTCY13E10.17c%2C E(): 0%3B MTCY48.17%2CE(): 0%3B MTCY98.0034c%2C E(): 0%3B MTCY03C7.23 E(): 0%3B MTCY98.0031c%2C E(): 0%3B MTCY31.06c%2C E(): 5.6e-17%3B MTCY359.33%2CE(): 2.3e-16. Nucleotide position 426909 in the genome sequence has been corrected%2C A:C resulting in W2591G.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE8;locus_tag=Rv0355c;product=PPE family protein PPE8;protein_id=CCP43085.1;transl_table=11
AL123456.3	EMBL	gene	434830	435474	.	-	.	ID=gene-Rv0356c;Name=Rv0356c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0356c
AL123456.3	EMBL	CDS	434830	435474	.	-	0	ID=cds-CCP43086.1;Parent=gene-Rv0356c;Dbxref=EnsemblGenomes-Gn:Rv0356c,EnsemblGenomes-Tr:CCP43086,InterPro:IPR006683,InterPro:IPR029069,UniProtKB/TrEMBL:O06307,NCBI_GP:CCP43086.1;Name=CCP43086.1;Note=Rv0356c%2C (MTCY13E10.18c)%2C len: 214 aa. Conserved protein%2C equivalent to AL023514|MLCB4_12 conserved hypothetical protein from Mycobacterium leprae (218 aa)%2CFASTA scores: opt: 1067%2C E(): 0%2C (73.4%25 identity in 214 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0356c;product=Conserved protein;protein_id=CCP43086.1;transl_table=11
AL123456.3	EMBL	gene	435471	436769	.	-	.	ID=gene-Rv0357c;Name=purA;gbkey=Gene;gene=purA;gene_biotype=protein_coding;locus_tag=Rv0357c
AL123456.3	EMBL	CDS	435471	436769	.	-	0	ID=cds-CCP43087.1;Parent=gene-Rv0357c;Dbxref=EnsemblGenomes-Gn:Rv0357c,EnsemblGenomes-Tr:CCP43087,GOA:P9WHN3,InterPro:IPR001114,InterPro:IPR018220,InterPro:IPR027417,NCBI_GP:CCP43087.1;Name=CCP43087.1;Note=Rv0357c%2C (MTCY13E10.19c)%2C len: 432 aa. Probable purA%2C adenylosuccinate synthase%2C equivalent to AL023514|MLCB4_13 from adenylosuccinate synthetase Mycobacterium leprae (432 aa)%2C FASTA scores: opt: 2555%2CE(): 0%2C (87.9%25 identity in 431 aa overlap). Also highly similar to many bacterial adenylosuccinates synthetases e.g. P12283|PURA_ECOLI adenylosuccinates synthetase from Escherichia coli (431 aa)%2C FASTA scores: E(): 0%2C (51.1%25 identity in 425 aa overlap)%3B etc. Belongs to the adenylosuccinate synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purA;locus_tag=Rv0357c;product=Probable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase);protein_id=CCP43087.1;transl_table=11
AL123456.3	EMBL	gene	436860	437507	.	+	.	ID=gene-Rv0358;Name=Rv0358;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0358
AL123456.3	EMBL	CDS	436860	437507	.	+	0	ID=cds-CCP43088.1;Parent=gene-Rv0358;Dbxref=EnsemblGenomes-Gn:Rv0358,EnsemblGenomes-Tr:CCP43088,UniProtKB/TrEMBL:O06308,NCBI_GP:CCP43088.1;Name=CCP43088.1;Note=Rv0358%2C (MTCY13E10.20)%2C len: 215 aa. Conserved protein%2C highly similar to ML0281|AL023514|MLCB4_14 conserved hypothetical protein from Mycobacterium leprae (229 aa)%2C FASTA scores: opt: 852%2C E(): 0%2C (62.9%25 identity in 229 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0358;product=Conserved protein;protein_id=CCP43088.1;transl_table=11
AL123456.3	EMBL	gene	437518	438297	.	+	.	ID=gene-Rv0359;Name=Rv0359;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0359
AL123456.3	EMBL	CDS	437518	438297	.	+	0	ID=cds-CCP43089.1;Parent=gene-Rv0359;Dbxref=EnsemblGenomes-Gn:Rv0359,EnsemblGenomes-Tr:CCP43089,GOA:L0T550,InterPro:IPR008915,NCBI_GP:CCP43089.1;Name=CCP43089.1;Note=Rv0359%2C (MTCY13E10.21)%2C len: 259 aa. Probable conserved integral membrane protein%2C highly similar to hypothetical or other membrane proteins e.g. AL133220|SCC75A_6|T50569 probable membrane protein from Streptomyces coelicolor (265 aa)%2C FASTA scores: opt: 642%2CE(): 0%2C (43.1%25 identity in 248 aa overlap)%3B P70995 hypothetical 24.7 kDa protein from Bacillus subtilis (219 aa)%2C FASTA scores: E(): 1.5e-12%2C (31.3%25 identity in 192 aa overlap). Contains neutral zinc metallopeptidases%2Czinc-binding region signature (PS00142).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv0359;product=Probable conserved integral membrane protein;protein_id=CCP43089.1;transl_table=11
AL123456.3	EMBL	gene	438302	438739	.	-	.	ID=gene-Rv0360c;Name=Rv0360c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0360c
AL123456.3	EMBL	CDS	438302	438739	.	-	0	ID=cds-CCP43090.1;Parent=gene-Rv0360c;Dbxref=EnsemblGenomes-Gn:Rv0360c,EnsemblGenomes-Tr:CCP43090,InterPro:IPR014487,UniProtKB/TrEMBL:O06310,NCBI_GP:CCP43090.1;Name=CCP43090.1;Note=Rv0360c%2C (MTCY13E10.22c)%2C len: 145 aa. Conserved protein%2C equivalent to AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c hypothetical protein from Mycobacterium leprae (137 aa)%2CFASTA scores: opt: 793%2C E(): 0%2C (85.4%25 identity in 137 aa overlap). And similar to AL049754|SCH10_25c|T36537 hypothetical protein from Streptomyces coelicolor (143 aa)%2CFASTA scores: opt: 497%2C E(): 3.2e-27%2C (55.8%25 identity in 138 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0360c;product=Conserved protein;protein_id=CCP43090.1;transl_table=11
AL123456.3	EMBL	gene	438822	439649	.	+	.	ID=gene-Rv0361;Name=Rv0361;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0361
AL123456.3	EMBL	CDS	438822	439649	.	+	0	ID=cds-CCP43091.1;Parent=gene-Rv0361;Dbxref=EnsemblGenomes-Gn:Rv0361,EnsemblGenomes-Tr:CCP43091,GOA:O06311,UniProtKB/TrEMBL:O06311,NCBI_GP:CCP43091.1;Name=CCP43091.1;Note=Rv0361%2C (MTCY13E10.23)%2C len: 275 aa. Probable conserved membrane protein (has hydrophobic stretch from residues 132-156)%2C equivalent to AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane protein from Mycobacterium leprae (292 aa)%2C FASTA scores: opt: 1044%2C E(): 0%2C (58.6%25 identity in 292 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0361;product=Probable conserved membrane protein;protein_id=CCP43091.1;transl_table=11
AL123456.3	EMBL	gene	439871	441253	.	+	.	ID=gene-Rv0362;Name=mgtE;gbkey=Gene;gene=mgtE;gene_biotype=protein_coding;locus_tag=Rv0362
AL123456.3	EMBL	CDS	439871	441253	.	+	0	ID=cds-CCP43092.1;Parent=gene-Rv0362;Dbxref=EnsemblGenomes-Gn:Rv0362,EnsemblGenomes-Tr:CCP43092,GOA:O06312,InterPro:IPR000644,InterPro:IPR006667,InterPro:IPR006668,InterPro:IPR006669,UniProtKB/TrEMBL:O06312,NCBI_GP:CCP43092.1;Name=CCP43092.1;Note=Rv0362%2C (MTCY13E10.24)%2C len: 460 aa. Possible mgtE%2Cmagnesium (Mg2+) transport transmembrane protein%3B C-terminal region is highly similar to MGTE|G780283 putative Mg2+ transporter from Providencia stuarti (314 aa)%2C FASTA scores: E(): 0%2C (47.2%25 identity in 307 aa overlap) (N-terminus extends approx. 150 aa further upstream compared to P. stuarti ORF). Also similar in part to others e.g. AAK20879.1|AF334760_1|AF334760 putative Mg2+ transporter from Aeromonas hydrophila (455 aa)%3B NP_231292.1|NC_002505 magnesium transporter from Vibrio cholerae (451 aa)%3B NP_102305.1|NC_002678 Mg2+ transport protein from Mesorhizobium loti (454 aa)%3B etc. Also similar to Rv1232c|MTV006.04c from Mycobacterium tuberculosis (435 aa). Extended hydrophobic segment spanning last 130 residues. Belongs to the MgtE family.;gbkey=CDS;gene=mgtE;locus_tag=Rv0362;product=Possible Mg2+ transport transmembrane protein MgtE;protein_id=CCP43092.1;transl_table=11
AL123456.3	EMBL	gene	441265	442299	.	-	.	ID=gene-Rv0363c;Name=fba;gbkey=Gene;gene=fba;gene_biotype=protein_coding;gene_synonym=fda;locus_tag=Rv0363c
AL123456.3	EMBL	CDS	441265	442299	.	-	0	ID=cds-CCP43093.1;Parent=gene-Rv0363c;Dbxref=EnsemblGenomes-Gn:Rv0363c,EnsemblGenomes-Tr:CCP43093,GOA:P9WQA3,InterPro:IPR000771,InterPro:IPR006411,InterPro:IPR013785,PDB:3EKL,PDB:3EKZ,PDB:3ELF,PDB:4A21,PDB:4A22,PDB:4DEF,PDB:4DEL,PDB:4LV4,NCBI_GP:CCP43093.1;Name=CCP43093.1;Note=Rv0363c%2C (MTCY13E10.25c)%2C len: 344 aa. Probable fba (alternate gene name: fda)%2C fructose bisphosphate aldolase %2C equivalent to AL023514|MLCB4_18|O69600|ALF_MYCLE fructose-bisphosphate aldolase from Mycobacterium leprae (345 aa)%2C FASTA scores: opt: 1995%2C E(): 0%2C (87.7%25 identity in 342 aa overlap). Also highly similar to others. Belongs to class II fructose-bisphosphate aldolase family. Cofactor: zinc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fba;locus_tag=Rv0363c;product=Probable fructose-bisphosphate aldolase Fba;protein_id=CCP43093.1;transl_table=11
AL123456.3	EMBL	gene	442395	443078	.	+	.	ID=gene-Rv0364;Name=Rv0364;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0364
AL123456.3	EMBL	CDS	442395	443078	.	+	0	ID=cds-CCP43094.1;Parent=gene-Rv0364;Dbxref=EnsemblGenomes-Gn:Rv0364,EnsemblGenomes-Tr:CCP43094,GOA:P9WP09,InterPro:IPR015414,NCBI_GP:CCP43094.1;Name=CCP43094.1;Note=Rv0364%2C (MTCY13E10.26)%2C len: 227 aa. Possible conserved transmembrane protein%2C equivalent to O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLCB 4_19 hypothetical 24.3 KDA protein from Mycobacterium leprae (222 aa)%2C FASTA scores: opt: 1027%2C E(): 0%2C (66.1%25 identity in 227 aa overlap). Shows strong similarity to DEDA_ECOLI|P09548 DedA protein protein from Escherichia coli FASTA scores: E(): 1.3e-28%2C (39.5%25 identity in 195 aa overlap). Similar also to Mycobacterium tuberculosis DedA protein Rv2637|MTCY441.0.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0364;product=Possible conserved transmembrane protein;protein_id=CCP43094.1;transl_table=11
AL123456.3	EMBL	gene	443067	444197	.	-	.	ID=gene-Rv0365c;Name=Rv0365c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0365c
AL123456.3	EMBL	CDS	443067	444197	.	-	0	ID=cds-CCP43095.1;Parent=gene-Rv0365c;Dbxref=EnsemblGenomes-Gn:Rv0365c,EnsemblGenomes-Tr:CCP43095,GOA:O06315,InterPro:IPR005198,InterPro:IPR008928,InterPro:IPR012341,InterPro:IPR014512,UniProtKB/TrEMBL:O06315,NCBI_GP:CCP43095.1;Name=CCP43095.1;Note=Rv0365c%2C (MTCY13E10.27c)%2C len: 376 aa (start uncertain). Conserved protein (see citation below)%2C very similar to G388212|CAA35191.1%2C a truncated ORF immediately upstream of the Corynebacterium glutamicum fda gene encoding fructose-1%2C6-biphosphate aldolase (304 aa)%2C FASTA scores: E(): 7.1e-19%2C (42.2%25 identity in 296 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0365c;product=Conserved protein;protein_id=CCP43095.1;transl_table=11
AL123456.3	EMBL	gene	444222	444815	.	-	.	ID=gene-Rv0366c;Name=Rv0366c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0366c
AL123456.3	EMBL	CDS	444222	444815	.	-	0	ID=cds-CCP43096.1;Parent=gene-Rv0366c;Dbxref=EnsemblGenomes-Gn:Rv0366c,EnsemblGenomes-Tr:CCP43096,GOA:O53701,InterPro:IPR010488,InterPro:IPR027417,UniProtKB/TrEMBL:O53701,NCBI_GP:CCP43096.1;Name=CCP43096.1;Note=Rv0366c%2C (MTV036.01c)%2C len: 197 aa. Conserved hypothetical protein%2C showing weak similarity to HI1395|P44173|YD95_HAEIN hypothetical protein from Haemophilus influenzae (140 aa)%2C FASTA scores: opt: 152%2CE(): 0.0015%2C (27.0%25 identity in 126 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00850 Glycine radical signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00850;locus_tag=Rv0366c;product=Conserved hypothetical protein;protein_id=CCP43096.1;transl_table=11
AL123456.3	EMBL	gene	444844	445233	.	-	.	ID=gene-Rv0367c;Name=Rv0367c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0367c
AL123456.3	EMBL	CDS	444844	445233	.	-	0	ID=cds-CCP43097.1;Parent=gene-Rv0367c;Dbxref=EnsemblGenomes-Gn:Rv0367c,EnsemblGenomes-Tr:CCP43097,InterPro:IPR021831,UniProtKB/TrEMBL:O53702,NCBI_GP:CCP43097.1;Name=CCP43097.1;Note=Rv0367c%2C (MTV036.02c)%2C len: 129 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0367c;product=Hypothetical protein;protein_id=CCP43097.1;transl_table=11
AL123456.3	EMBL	gene	445314	446525	.	-	.	ID=gene-Rv0368c;Name=Rv0368c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0368c
AL123456.3	EMBL	CDS	445314	446525	.	-	0	ID=cds-CCP43098.1;Parent=gene-Rv0368c;Dbxref=EnsemblGenomes-Gn:Rv0368c,EnsemblGenomes-Tr:CCP43098,GOA:O53703,InterPro:IPR002035,InterPro:IPR008912,InterPro:IPR011195,UniProtKB/TrEMBL:O53703,NCBI_GP:CCP43098.1;Name=CCP43098.1;Note=Rv0368c%2C (MTV036.03c)%2C len: 403 aa. Conserved hypothetical protein%2C showing some similarity to AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium japonicum (422 aa)%2C FASTA scores: opt: 341%2C E(): 4.3e-13%2C(27.4%25 identity in 387 aa overlap)%3B Rv2425c|MTCY428_22 hypothetical protein from Mycobacterium tuberculosis FASTA score: (30.7%25 identity in 238 aa overlap). Contains PS00213 Lipocalin signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00213;locus_tag=Rv0368c;product=Conserved hypothetical protein;protein_id=CCP43098.1;transl_table=11
AL123456.3	EMBL	gene	446531	447046	.	-	.	ID=gene-Rv0369c;Name=Rv0369c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0369c
AL123456.3	EMBL	CDS	446531	447046	.	-	0	ID=cds-CCP43099.1;Parent=gene-Rv0369c;Dbxref=EnsemblGenomes-Gn:Rv0369c,EnsemblGenomes-Tr:CCP43099,GOA:O53704,InterPro:IPR010419,InterPro:IPR023393,UniProtKB/TrEMBL:O53704,NCBI_GP:CCP43099.1;Name=CCP43099.1;Note=Rv0369c%2C (MTV036.04c)%2C len: 171 aa. Possible membrane protein oxidoreductase%2C similar to ORF 4 of the Pseudomonas thermocarboxydovorans protein of cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from Pseudomonas thermocarboxydovorans (171 aa)%2C FASTA scores: opt: 226%2CE(): 9.8e-08%2C (31.3%25 identity in 166 aa overlap). Also similar to MTV036.05%2C MTV036.08%2C MTV036.09%2C and MTV026.10.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0369c;product=Possible membrane oxidoreductase;protein_id=CCP43099.1;transl_table=11
AL123456.3	EMBL	gene	447147	448043	.	-	.	ID=gene-Rv0370c;Name=Rv0370c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0370c
AL123456.3	EMBL	CDS	447147	448043	.	-	0	ID=cds-CCP43100.1;Parent=gene-Rv0370c;Dbxref=EnsemblGenomes-Gn:Rv0370c,EnsemblGenomes-Tr:CCP43100,GOA:O53705,InterPro:IPR003593,InterPro:IPR011704,InterPro:IPR027417,UniProtKB/TrEMBL:O53705,NCBI_GP:CCP43100.1;Name=CCP43100.1;Note=Rv0370c%2C (MTV036.05c)%2C len: 298 aa. Possible oxidoreductase%2C similar to many hypothetical proteins%2C but also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL gene cluster from Pseudomonas/Oligotropha carboxidovorans (295 aa)%2C FASTA scores: opt: 851%2C E(): 0%2C (48.2%25 identity in 282 aa overlap)%3B AJ224684|BJAJ4684_3 cooxS from Bradyrhizobium japonicum (302 aa)%2C FASTA scores: opt: 881%2CE(): 0%2C (47.6%25 identity in 290 aa overlap). Also highly similar to MTCY428_21 from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0370c;product=Possible oxidoreductase;protein_id=CCP43100.1;transl_table=11
AL123456.3	EMBL	gene	448040	448633	.	-	.	ID=gene-Rv0371c;Name=Rv0371c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0371c
AL123456.3	EMBL	CDS	448040	448633	.	-	0	ID=cds-CCP43101.1;Parent=gene-Rv0371c;Dbxref=EnsemblGenomes-Gn:Rv0371c,EnsemblGenomes-Tr:CCP43101,InterPro:IPR025877,InterPro:IPR029044,UniProtKB/TrEMBL:I6WY86,NCBI_GP:CCP43101.1;Name=CCP43101.1;Note=Rv0371c%2C (MTV036.06c)%2C len: 197 aa. Conserved hypothetical protein%2C similar to other hypothetical proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 hypothetical protein from Streptomyces coelicolor (207 aa)%2CFASTA scores: opt: 247%2C E(): 4.5e-09%2C (32.3%25 identity in 195 aa overlap). Also weak similarity with YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE from Bacillus subtilis (197 aa)%2C FASTA scores: opt: 217%2CE(): 2.5e-08%2C (27.0%25 identity in 174 aa overlap).;gbkey=CDS;locus_tag=Rv0371c;product=Conserved hypothetical protein;protein_id=CCP43101.1;transl_table=11
AL123456.3	EMBL	gene	448630	449385	.	-	.	ID=gene-Rv0372c;Name=Rv0372c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0372c
AL123456.3	EMBL	CDS	448630	449385	.	-	0	ID=cds-CCP43102.1;Parent=gene-Rv0372c;Dbxref=EnsemblGenomes-Gn:Rv0372c,EnsemblGenomes-Tr:CCP43102,GOA:O53707,InterPro:IPR003777,InterPro:IPR027051,UniProtKB/TrEMBL:O53707,NCBI_GP:CCP43102.1;Name=CCP43102.1;Note=Rv0372c%2C (MTV036.07c)%2C len: 251 aa. Conserved hypothetical protein%2C showing some similarity with CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa)%3B AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa)%2C FASTA scores: opt: 186%2C E(): 1.6e-05%2C (41.1%25 identity in 95 aa overlap). Also similar to upstream ORF Rv0376c from Mycobacterium tuberculosis (380 aa)%2C FASTA scores: E(): 6.8e-07%2C (31.0%25 identity in 277 aa overlap).;gbkey=CDS;locus_tag=Rv0372c;product=Conserved hypothetical protein;protein_id=CCP43102.1;transl_table=11
AL123456.3	EMBL	gene	449404	451803	.	-	.	ID=gene-Rv0373c;Name=Rv0373c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0373c
AL123456.3	EMBL	CDS	449404	451803	.	-	0	ID=cds-CCP43103.1;Parent=gene-Rv0373c;Dbxref=EnsemblGenomes-Gn:Rv0373c,EnsemblGenomes-Tr:CCP43103,GOA:O53708,InterPro:IPR000674,InterPro:IPR008274,InterPro:IPR012780,UniProtKB/TrEMBL:O53708,NCBI_GP:CCP43103.1;Name=CCP43103.1;Note=Rv0373c%2C (MTV036.08c)%2C len: 799 aa. Probable carbon monoxide dehydrogenase%2C large chain%2C highly similar to others e.g. AAD00363.1| U80806|CUTL carbon monoxide dehydrogenase large subunit CutL protein from Hydrogenophaga pseudoflava (803 aa)%3B S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA carbon-monoxide dehydrogenase large chain (cut operon) from Pseudomonas thermocarboxydovorans (842 aa)%3B C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL carbon-monoxide dehydrogenase large chain (cluster coxMSL) from Pseudomonas/Oligotropha carboxydovorans (809 aa)%2CFASTA scores: opt: 2484%2C E(): 0%2C (56.0%25 identity in 804 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0373c;product=Probable carbon monoxyde dehydrogenase (large chain);protein_id=CCP43103.1;transl_table=11
AL123456.3	EMBL	gene	451800	452279	.	-	.	ID=gene-Rv0374c;Name=Rv0374c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0374c
AL123456.3	EMBL	CDS	451800	452279	.	-	0	ID=cds-CCP43104.1;Parent=gene-Rv0374c;Dbxref=EnsemblGenomes-Gn:Rv0374c,EnsemblGenomes-Tr:CCP43104,GOA:O53709,InterPro:IPR001041,InterPro:IPR002888,InterPro:IPR012675,UniProtKB/TrEMBL:O53709,NCBI_GP:CCP43104.1;Name=CCP43104.1;Note=Rv0374c%2C (MTV036.09c)%2C len: 159 aa. Probable carbon monoxide dehydrogenase%2C small chain%2C highly similar to others e.g. B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide dehydrogenase small chain from Pseudomonas/Oligotropha carboxydovorans (166 aa)%2C FASTA scores: opt: 662%2C E(): 0%2C (59.3%25 identity in 150 aa overlap)%3B CAA12063.1|AJ224684 putative carbon monoxide dehydrogenase small subunit from Bradyrhizobium japonicum (161 aa)%3B S49123|509390|CAA54901.1|X77931|CUTC carbon-monoxide dehydrogenase small chain from Pseudomonas thermocarboxydovorans (163 aa)%3B etc.;gbkey=CDS;locus_tag=Rv0374c;product=Probable carbon monoxyde dehydrogenase (small chain);protein_id=CCP43104.1;transl_table=11
AL123456.3	EMBL	gene	452294	453154	.	-	.	ID=gene-Rv0375c;Name=Rv0375c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0375c
AL123456.3	EMBL	CDS	452294	453154	.	-	0	ID=cds-CCP43105.1;Parent=gene-Rv0375c;Dbxref=EnsemblGenomes-Gn:Rv0375c,EnsemblGenomes-Tr:CCP43105,GOA:I6Y7N2,InterPro:IPR002346,InterPro:IPR005107,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,UniProtKB/TrEMBL:I6Y7N2,NCBI_GP:CCP43105.1;Name=CCP43105.1;Note=Rv0375c%2C (MTV036.10c)%2C len: 286 aa. Probable carbon monoxide dehydrogenase%2C medium chain%2C similar to others e.g. AAD00361.1|U80806|CUTM carbon monoxide dehydrogenase middle subunit from Hydrogenophaga pseudoflava (287 aa)%3B S49122|509389|CAA54900.1|X77931|CUTB carbon-monoxide dehydrogenase medium chain from Pseudomonas thermocarboxydovorans (287 aa)%3B A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH carbon-monoxide dehydrogenase medium chain from Pseudomonas/Oligotropha carboxydovorans (288 aa)%2C FASTA scores: opt: 594%2C E(): 0%2C (37.5%25 identity in 277 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0375c;product=Probable carbon monoxyde dehydrogenase (medium chain);protein_id=CCP43105.1;transl_table=11
AL123456.3	EMBL	gene	453230	454372	.	-	.	ID=gene-Rv0376c;Name=Rv0376c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0376c
AL123456.3	EMBL	CDS	453230	454372	.	-	0	ID=cds-CCP43106.1;Parent=gene-Rv0376c;Dbxref=EnsemblGenomes-Gn:Rv0376c,EnsemblGenomes-Tr:CCP43106,InterPro:IPR003777,InterPro:IPR027051,UniProtKB/TrEMBL:O53711,NCBI_GP:CCP43106.1;Name=CCP43106.1;Note=Rv0376c%2C (MTV036.11c)%2C len: 380 aa. Conserved hypothetical protein%2C highly similar to T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical protein from Streptomyces coelicolor (395 aa)%3B and AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from Arthrobacter nicotinovorans (377 aa). And similar to other conserved hypothetical proteins e.g. NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical protein from Mesorhizobium loti (245 aa). Note that C-terminus shows similarity with C-termini of CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa)%3B CAB76250.1|X82447|COXI CoxI protein from Pseudomonas/Oligotropha carboxidovorans (330 aa)%3B and AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum (176 aa)%2C FASTA scores: E(): 1.9e-17%2C (47.1%25 identity in 138 aa overlap). Also some partial similarity with AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum (107 aa)%2C FASTA scores: opt: 321%2C E(): 4.2e-14%2C (53.3%25 identity in 92 aa overlap)%3B E1184330|Z99120|YURF YURF protein from Bacillus subtilis (330 aa)%2C FASTA scores: opt: 170%2C E(): 2.9e- 16%2C (27.5%25 identity in 345 aa overlap). Also similar to downstream ORF Rv0372c from Mycobacterium tuberculosis (251 aa)%2C FASTA scores: E(): 2.1e-06%2C (30.7%25 identity in 277 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0376c;product=Conserved hypothetical protein;protein_id=CCP43106.1;transl_table=11
AL123456.3	EMBL	gene	454421	455386	.	+	.	ID=gene-Rv0377;Name=Rv0377;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0377
AL123456.3	EMBL	CDS	454421	455386	.	+	0	ID=cds-CCP43107.1;Parent=gene-Rv0377;Dbxref=EnsemblGenomes-Gn:Rv0377,EnsemblGenomes-Tr:CCP43107,GOA:P9WMF7,InterPro:IPR000847,InterPro:IPR005119,InterPro:IPR011991,NCBI_GP:CCP43107.1;Name=CCP43107.1;Note=Rv0377%2C (MTV036.12)%2C len: 321 aa. Probable transcription regulator%2C lysR family%2C showing similarity with many hypothetical transcriptional regulators lysR homolog e.g. P32484|YEIE_ECOLI|M89774 hypothetical transcriptional regulator from Escherichia coli (293 aa)%2CFASTA scores: opt: 265%2C E(): 4.9e-11%2C (28.6%25 identity in 266 aa overlap). Also similar to Rv2282c from Mycobacterium tuberculosis. Contains PS00044 bacterial regulatory protein lysR family signature. Seems to belong to the LysR family of transcriptional regulators.;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv0377;product=Probable transcriptional regulatory protein (probably LysR-family);protein_id=CCP43107.1;transl_table=11
AL123456.3	EMBL	gene	455637	455858	.	+	.	ID=gene-Rv0378;Name=Rv0378;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0378
AL123456.3	EMBL	CDS	455637	455858	.	+	0	ID=cds-CCP43108.1;Parent=gene-Rv0378;Dbxref=EnsemblGenomes-Gn:Rv0378,EnsemblGenomes-Tr:CCP43108,UniProtKB/TrEMBL:O53713,NCBI_GP:CCP43108.1;Name=CCP43108.1;Note=Rv0378%2C (MTV036.13)%2C len: 73 aa. Conserved hypothetical gly-rich protein%2C showing some similarity to Mycobacterium tuberculosis PE_PGRS family%3B also similar to MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD protein (1011 aa)%2C FASTA scores: opt: 237%2C E(): 0.0032%2C(58.7%25 identity in 63 aa overlap)%3B MTV043_25.;gbkey=CDS;locus_tag=Rv0378;product=Conserved hypothetical glycine rich protein;protein_id=CCP43108.1;transl_table=11
AL123456.3	EMBL	gene	455977	456192	.	+	.	ID=gene-Rv0379;Name=secE2;gbkey=Gene;gene=secE2;gene_biotype=protein_coding;locus_tag=Rv0379
AL123456.3	EMBL	CDS	455977	456192	.	+	0	ID=cds-CCP43109.1;Parent=gene-Rv0379;Dbxref=EnsemblGenomes-Gn:Rv0379,EnsemblGenomes-Tr:CCP43109,GOA:Q6MX43,InterPro:IPR009923,InterPro:IPR025543,PDB:3ONR,NCBI_GP:CCP43109.1;Name=CCP43109.1;Note=Rv0379%2C (MTV036.14)%2C len: 71 aa. Possible secE2%2Cprotein transport protein%2C showing similarity with P27340|S61G_SULSO|SECE preprotein translocase SECE subunit (protein transport protein SEC61 gamma subunit homolog) from Sulfolobus acidocaldarius (65 aa)%2C FASTA scores: opt: 79%2C E(): 4.7. (30.3%25 identity in 66 aa overlap)%3B and hypothetical proteins e.g. Q9HPW4|VNG1446H hypothetical protein from Halobacterium sp. strain NRC-1 (77 aa)%3B Q9I794|PA0038 hypothetical protein from Pseudomonas aeruginosa (71 aa)%3B etc. Also highly similar to U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis protein from a patient isolate (116 aa)%2C FASTA scores: opt: 443%2C E(): 7.7e-29%2C (98.6%25 identity in 71 aa overlap). Note that for Rv0379|MTV036.14%2C a translation initiation region different to the one in U85467|MTU85467_1 was chosen. Could be a part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c%2C SECD|Rv2587c%2CSECE|Rv0638%2C SECF|Rv2586c%2C SECG|Rv1440 and SECY|Rv0732.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=secE2;locus_tag=Rv0379;product=Possible protein transport protein SecE2;protein_id=CCP43109.1;transl_table=11
AL123456.3	EMBL	gene	456268	456819	.	-	.	ID=gene-Rv0380c;Name=Rv0380c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0380c
AL123456.3	EMBL	CDS	456268	456819	.	-	0	ID=cds-CCP43110.1;Parent=gene-Rv0380c;Dbxref=EnsemblGenomes-Gn:Rv0380c,EnsemblGenomes-Tr:CCP43110,GOA:O53715,InterPro:IPR001537,InterPro:IPR029026,InterPro:IPR029028,UniProtKB/TrEMBL:O53715,NCBI_GP:CCP43110.1;Name=CCP43110.1;Note=Rv0380c%2C (MTV036.15c)%2C len: 183 aa. Possible RNA methyltransferase%2C equivalent to CAC32002.1|AL583925 possible RNA methyltransferase from Mycobacterium leprae (182 aa). Also some similarity with others methyltransferases e.g. P19396|TRMH_ECOLI|78514|JV0043 tRNA (guanosine-2'-O-)-methyltransferase (tRNA methyltransferase) from Escherichia coli (229 aa)%2C FASTA scores: opt: 227%2C E(): 1.4e-09%2C (28.9%25 identity in 166 aa overlap). Also similar to Rv0881%2C Rv3579c%2C Rv1644 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0380c;product=Possible RNA methyltransferase (RNA methylase);protein_id=CCP43110.1;transl_table=11
AL123456.3	EMBL	gene	456915	457823	.	-	.	ID=gene-Rv0381c;Name=Rv0381c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0381c
AL123456.3	EMBL	CDS	456915	457823	.	-	0	ID=cds-CCP43111.1;Parent=gene-Rv0381c;Dbxref=EnsemblGenomes-Gn:Rv0381c,EnsemblGenomes-Tr:CCP43111,GOA:O53716,UniProtKB/TrEMBL:O53716,NCBI_GP:CCP43111.1;Name=CCP43111.1;Note=Rv0381c%2C (MTV036.16c)%2C len: 302 aa. Hypothetical unknown protein. Equivalent to AAK44616.1 from Mycobacterium tuberculosis strain CDC1551 (254 aa) but longer 48 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0381c;product=Hypothetical protein;protein_id=CCP43111.1;transl_table=11
AL123456.3	EMBL	gene	457841	458380	.	-	.	ID=gene-Rv0382c;Name=pyrE;gbkey=Gene;gene=pyrE;gene_biotype=protein_coding;gene_synonym=umpA;locus_tag=Rv0382c
AL123456.3	EMBL	CDS	457841	458380	.	-	0	ID=cds-CCP43112.1;Parent=gene-Rv0382c;Dbxref=EnsemblGenomes-Gn:Rv0382c,EnsemblGenomes-Tr:CCP43112,GOA:P9WHK9,InterPro:IPR000836,InterPro:IPR004467,InterPro:IPR023031,InterPro:IPR029057,NCBI_GP:CCP43112.1;Name=CCP43112.1;Note=Rv0382c%2C (MTV036.17c)%2C len: 179 aa. Probable pyrE%2Corotate phosphoribosyltransferase%2C equivalent to CAC32004.1|AL583925 probable purine/pyrimidine phosphoribosyltransferase from Mycobacterium leprae (179 aa). Also highly similar to many others e.g. T36540|4753874|CAB42037.1|AL049754|SCH10.28c probable orotate phosphoribosyltransferase from Streptomyces coelicolor (182 aa)%3B H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable orotate phosphoribosyltransferase from Methanobacterium thermoautotrophicum (180 aa)%2C FASTA scores: opt: 389%2C E(): 2.7e-20%2C (40.7%25 identity in 172 aa overlap)%3B O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 orotate phosphoribosyltransferase from Sulfolobus acidocaldarius (197 aa)%3B etc. Note that also similar to other puridine 5'-monophosphate synthases (umpA genes%3B UMP synthases)%2Cgenerally in N-terminus that corresponds to orotate phosphoribosyltransferase activity. Contains PS00589 PTS HPR component serine phosphorylation site signature. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Note that previously known as umpA. Nucleotide position 458282 in the genome sequence has been corrected%2CA:G resulting in Y33Y.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrE;inference=protein motif:PROSITE:PS00589;locus_tag=Rv0382c;product=Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase);protein_id=CCP43112.1;transl_table=11
AL123456.3	EMBL	gene	458461	459315	.	-	.	ID=gene-Rv0383c;Name=Rv0383c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0383c
AL123456.3	EMBL	CDS	458461	459315	.	-	0	ID=cds-CCP43113.1;Parent=gene-Rv0383c;Dbxref=EnsemblGenomes-Gn:Rv0383c,EnsemblGenomes-Tr:CCP43113,GOA:O53718,UniProtKB/TrEMBL:O53718,NCBI_GP:CCP43113.1;Name=CCP43113.1;Note=Rv0383c%2C (MTV036.18c)%2C len: 284 aa. Possible conserved secreted protein%2C with hydrophobic stretch in N-terminus and Pro-rich C-terminus. Equivalent to CAC32006.1|AL583925 possible secreted protein from Mycobacterium leprae (286 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0383c;product=Possible conserved secreted protein;protein_id=CCP43113.1;transl_table=11
AL123456.3	EMBL	gene	459456	462002	.	-	.	ID=gene-Rv0384c;Name=clpB;gbkey=Gene;gene=clpB;gene_biotype=protein_coding;gene_synonym=htpM;locus_tag=Rv0384c
AL123456.3	EMBL	CDS	459456	462002	.	-	0	ID=cds-CCP43114.1;Parent=gene-Rv0384c;Dbxref=EnsemblGenomes-Gn:Rv0384c,EnsemblGenomes-Tr:CCP43114,GOA:P9WPD1,InterPro:IPR001270,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR004176,InterPro:IPR017730,InterPro:IPR018368,InterPro:IPR019489,InterPro:IPR023150,InterPro:IPR027417,InterPro:IPR028299,NCBI_GP:CCP43114.1;Name=CCP43114.1;Note=Rv0384c%2C (MTV036.19c)%2C len: 848 aa. Probable clpB (alternate gene name: htpM)%2C endopeptidase ATP-binding protein%2C chain B%2C equivalent to AC32007.1|AL583925 heat shock protein from Mycobacterium leprae (848 aa). Also highly similar to others e.g. P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB protein (heat-inducible expression) from Corynebacterium glutamicum (852 aa)%2C FASTA scores: opt: 4113%2C E(): 0%2C(74.5%25 identity in 846 aa overlap)%3B T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c probable ATP-dependent proteinase ATP-binding chain from Streptomyces coelicolor (853 aa)%3B P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB protein (heat shock protein F84.1) from Escherichia coli strains K12 and O157:H7 (857 aa)%3B etc. Also similar to Rv3596c|ClpC from Mycobacterium tuberculosis. Contains PS00870 and PS00871 Chaperonins clpA/B signatures and two PS000017 ATP/GTP-binding site motives a (P-loop). Belongs to the CLPA/CLPB family. Contains probable coiled-coil domain from aa 411-503. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=clpB;inference=protein motif:PROSITE:PS00871;locus_tag=Rv0384c;product=Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1);protein_id=CCP43114.1;transl_table=11
AL123456.3	EMBL	gene	462135	463307	.	+	.	ID=gene-Rv0385;Name=Rv0385;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0385
AL123456.3	EMBL	CDS	462135	463307	.	+	0	ID=cds-CCP43115.1;Parent=gene-Rv0385;Dbxref=EnsemblGenomes-Gn:Rv0385,EnsemblGenomes-Tr:CCP43115,GOA:Q7ARS9,InterPro:IPR000971,InterPro:IPR001221,InterPro:IPR001433,InterPro:IPR001709,InterPro:IPR008333,InterPro:IPR009050,InterPro:IPR012292,InterPro:IPR017927,InterPro:IPR017938,UniProtKB/TrEMBL:Q7ARS9,NCBI_GP:CCP43115.1;Name=CCP43115.1;Note=Rv0385%2C (MTV036.20)%2C len: 390 aa. Probable monooxygenase%2C similar to T37003|5738846|CAB52917.1|AL109949 probable flavohemoprotein from Streptomyces coelicolor (435 aa)%3B and similar in part (C-termini) to various monooxygenases e.g. P19734|DMPP_PSESP|94993|F37831 phenol hydroxylase P5 protein (phenol 2-monooxygenase P5 component) from Pseudomonas putida (353 aa)%2C FASTA scores: opt: 363%2C E(): 4.2e-16%2C (31.8%25 identity in 255 aa overlap)%3B S47292|2120861|pir|S70085 phenol 2-monooxygenase chain mopP from Acinetobacter calcoaceticus (350 aa)%3B P21394|XYLA_PSEPU|94933|B37316 xylene monooxygenase electron transfer component [includes: ferredoxin%3B ferredoxin--NAD(+) reductase] from Pseudomonas putida plasmid pWW0 (350 aa)%3B AAC38360.1|AF043544|NtnMA|ntnA reductase component of 4-nitrotoluene monooxygenase from Pseudomonas sp. (328 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0385;product=Probable monooxygenase;protein_id=CCP43115.1;transl_table=11
AL123456.3	EMBL	gene	463411	466668	.	+	.	ID=gene-Rv0386;Name=Rv0386;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0386
AL123456.3	EMBL	CDS	463411	466668	.	+	0	ID=cds-CCP43116.1;Parent=gene-Rv0386;Dbxref=EnsemblGenomes-Gn:Rv0386,EnsemblGenomes-Tr:CCP43116,GOA:O53720,InterPro:IPR000792,InterPro:IPR001054,InterPro:IPR002182,InterPro:IPR011990,InterPro:IPR011991,InterPro:IPR016032,InterPro:IPR027417,InterPro:IPR029787,UniProtKB/TrEMBL:O53720,NCBI_GP:CCP43116.1;Name=CCP43116.1;Note=Rv0386%2C (MTV036.21)%2C len: 1085 aa. Probable regulatory protein%2C LuxR/uhpA family%2C highly similar to CAC30706.1|AL583923 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar in part to other regulatory proteins e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa)%3B N-terminus of CAB92369.1|AL356612 putative AfsR-like regulatory protein from Streptomyces coelicolor (1114 aa)%3B N-terminus of NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional regulator from Mesorhizobium loti (952 aa)%3B AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa)%2C FASTA scores: opt: 224%2C E() : 1.1e-06%2C(26.1%25 identity in 867 aa overlap)%3B etc. Also similar to many putative Mycobacterium tuberculosis regulatory proteins e.g. AL0212|MTV008_44 (1137 aa)%2C FASTA scores: opt: 3756%2C E(): 0%2C (56.7%25 identity in 1089 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2CPS00622 Bacterial regulatory proteins%2C luxR family signature and probable helix-turn-helix motif at aa 1042-1063 (Score 1025%2C +2.68 S D). Belongs to the LuxR/UhpA family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00622;locus_tag=Rv0386;product=Probable transcriptional regulatory protein (probably LuxR/UhpA-family);protein_id=CCP43116.1;transl_table=11
AL123456.3	EMBL	gene	466672	467406	.	-	.	ID=gene-Rv0387c;Name=Rv0387c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0387c
AL123456.3	EMBL	CDS	466672	467406	.	-	0	ID=cds-CCP43117.1;Parent=gene-Rv0387c;Dbxref=EnsemblGenomes-Gn:Rv0387c,EnsemblGenomes-Tr:CCP43117,InterPro:IPR022171,UniProtKB/TrEMBL:L0T6I4,NCBI_GP:CCP43117.1;Name=CCP43117.1;Note=Rv0387c%2C (MTV036.22c)%2C len: 244 aa. Conserved hypothetical protein%2C showing some similarity to MTCI237.20c%2C and M17282|HUMEL20_1 Human elastin gene%2C exon 1%2C Elastin (687 aa)%2C FASTA scores: opt: 193%2C E(): 0.35%2C(34.4%25 identity in 189 aa overlap).;gbkey=CDS;locus_tag=Rv0387c;product=Conserved hypothetical protein;protein_id=CCP43117.1;transl_table=11
AL123456.3	EMBL	gene	467459	468001	.	-	.	ID=gene-Rv0388c;Name=PPE9;gbkey=Gene;gene=PPE9;gene_biotype=protein_coding;locus_tag=Rv0388c
AL123456.3	EMBL	CDS	467459	468001	.	-	0	ID=cds-CCP43118.1;Parent=gene-Rv0388c;Dbxref=EnsemblGenomes-Gn:Rv0388c,EnsemblGenomes-Tr:CCP43118,InterPro:IPR000030,UniProtKB/TrEMBL:L0T6B3,NCBI_GP:CCP43118.1;Name=CCP43118.1;Note=Rv0388c%2C (MTV036.23c)%2C len: 180 aa. PPE9%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to others e.g. MTCY10G2_10|Z92539 from Mycobacterium tuberculosis (391 aa)%2C FASTA scores: opt: 667%2C E(): 0%2C(58.3%25 identity in 180 aa overlap) but much shorter.;gbkey=CDS;gene=PPE9;locus_tag=Rv0388c;product=PPE family protein PPE9;protein_id=CCP43118.1;transl_table=11
AL123456.3	EMBL	gene	468335	469594	.	+	.	ID=gene-Rv0389;Name=purT;gbkey=Gene;gene=purT;gene_biotype=protein_coding;locus_tag=Rv0389
AL123456.3	EMBL	CDS	468335	469594	.	+	0	ID=cds-CCP43119.1;Parent=gene-Rv0389;Dbxref=EnsemblGenomes-Gn:Rv0389,EnsemblGenomes-Tr:CCP43119,GOA:P95197,InterPro:IPR003135,InterPro:IPR005862,InterPro:IPR011761,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,UniProtKB/TrEMBL:P95197,NCBI_GP:CCP43119.1;Name=CCP43119.1;Note=Rv0389%2C (MTCY04D9.01%2C MTV036.24)%2C len: 419 aa. Probable purT%2C phosphoribosylglycinamide formyltransferase 2%2C similar to others e.g. P33221|PURT_ECOLI|B1849 phosphoribosylglycinamide formyltransferase 2 from Escherichia coli strain K-12 (391 aa)%2C FASTA scores: opt: 481%2C E(): 1.3e-22%2C (40.1%25 identity in 379 aa overlap)%3B etc. Belongs to the PurK / PurT family. Cofactor: magnesium.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purT;locus_tag=Rv0389;product=Probable phosphoribosylglycinamide formyltransferase 2 PurT (GART 2) (gar transformylase 2) (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase);protein_id=CCP43119.1;transl_table=11
AL123456.3	EMBL	gene	469591	470013	.	+	.	ID=gene-Rv0390;Name=Rv0390;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0390
AL123456.3	EMBL	CDS	469591	470013	.	+	0	ID=cds-CCP43120.1;Parent=gene-Rv0390;Dbxref=EnsemblGenomes-Gn:Rv0390,EnsemblGenomes-Tr:CCP43120,InterPro:IPR001763,PDB:2FSX,UniProtKB/TrEMBL:P95198,NCBI_GP:CCP43120.1;Name=CCP43120.1;Note=Rv0390%2C (MTCY04D9.02)%2C len: 140 aa. Conserved protein%2C equivalent to AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein from Mycobacterium leprae (147 aa)%2C FASTA scores: opt: 778%2CE(): 0%2C (79.0%25 identity in 138 aa overlap). Also similar to hypothetical proteins from several Rickettsia species.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0390;product=Conserved protein;protein_id=CCP43120.1;transl_table=11
AL123456.3	EMBL	gene	470010	471230	.	+	.	ID=gene-Rv0391;Name=metZ;gbkey=Gene;gene=metZ;gene_biotype=protein_coding;locus_tag=Rv0391
AL123456.3	EMBL	CDS	470010	471230	.	+	0	ID=cds-CCP43121.1;Parent=gene-Rv0391;Dbxref=EnsemblGenomes-Gn:Rv0391,EnsemblGenomes-Tr:CCP43121,GOA:P9WGB5,InterPro:IPR000277,InterPro:IPR006234,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,PDB:3NDN,NCBI_GP:CCP43121.1;Name=CCP43121.1;Note=Rv0391%2C (MTCY04D9.03)%2C len: 406 aa. Probable metZ%2CO-succinylhomoserine sulfhydrylase%2C equivalent%2C but shorter 20 aa in N-terminus%2C to AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from Mycobacterium leprae (426 aa). Also highly similar to others e.g. METZ_PSEAE|P55218 o-succinylhomoserine sulfhydrylase from Pseudomonas aeruginosa (403 aa)%2C FASTA scores: opt: 1175%2CE(): 0%2C (47.2%25 identity in 392 aa overlap)%3B etc. Belongs to the trans-sulfuration enzymes family. Could also be a cystathionine gamma-synthase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metZ;locus_tag=Rv0391;product=Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase);protein_id=CCP43121.1;transl_table=11
AL123456.3	EMBL	gene	471227	472639	.	-	.	ID=gene-Rv0392c;Name=ndhA;gbkey=Gene;gene=ndhA;gene_biotype=protein_coding;locus_tag=Rv0392c
AL123456.3	EMBL	CDS	471227	472639	.	-	0	ID=cds-CCP43122.1;Parent=gene-Rv0392c;Dbxref=EnsemblGenomes-Gn:Rv0392c,EnsemblGenomes-Tr:CCP43122,GOA:P95200,InterPro:IPR001327,InterPro:IPR013027,InterPro:IPR023753,UniProtKB/TrEMBL:P95200,NCBI_GP:CCP43122.1;Name=CCP43122.1;Note=Rv0392c%2C (MTCY04D9.04c)%2C len: 470 aa. Probable ndhA%2Cmembrane NADH dehydrogenase%2C equivalent to many e.g. AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium smegmatis (457 aa)%2C FASTA scores: opt: 1991%2C E(): 0%2C (67.9%25 identity in 458 aa overlap)%3B MLCB1788_3 NADH dehydrogenase from Mycobacterium leprae (466 aa)%2C FASTA score: (62.5%25 identity in 467 aa overlap). Also similar to others from several organisms e.g. P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH dehydrogenase from Escherichia coli (434 aa)%3B and Rv0392c|ndhB from Mycobacterium tuberculosis. Has hydrophobic stretch in C-terminus. Belongs to the NADH dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ndhA;locus_tag=Rv0392c;product=Probable membrane NADH dehydrogenase NdhA;protein_id=CCP43122.1;transl_table=11
AL123456.3	EMBL	gene	472781	474106	.	+	.	ID=gene-Rv0393;Name=Rv0393;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0393
AL123456.3	EMBL	CDS	472781	474106	.	+	0	ID=cds-CCP43123.1;Parent=gene-Rv0393;Dbxref=EnsemblGenomes-Gn:Rv0393,EnsemblGenomes-Tr:CCP43123,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:P95201,NCBI_GP:CCP43123.1;Name=CCP43123.1;Note=Rv0393%2C (MTCY04D9.05)%2C len: 441 aa. Member of Mycobacterium tuberculosis 13E12 repeat family of conserved proteins%2C similar to many e.g. Rv1148c%2C Rv1945%2C Rv3467%2CRv0336|MTCY279_3 (503 aa)%2C FASTA scores: E(): 0%2C (61.1%25 identity in 347 aa overlap).;gbkey=CDS;locus_tag=Rv0393;product=Conserved 13E12 repeat family protein;protein_id=CCP43123.1;transl_table=11
AL123456.3	EMBL	gene	474122	474841	.	-	.	ID=gene-Rv0394c;Name=Rv0394c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0394c
AL123456.3	EMBL	CDS	474122	474841	.	-	0	ID=cds-CCP43124.1;Parent=gene-Rv0394c;Dbxref=EnsemblGenomes-Gn:Rv0394c,EnsemblGenomes-Tr:CCP43124,UniProtKB/TrEMBL:P95202,NCBI_GP:CCP43124.1;Name=CCP43124.1;Note=Rv0394c%2C (MTCY04D9.06c)%2C len: 239 aa. Possible secreted protein%2C sharing no homology with other proteins. Has hydrophobic stretch at its N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0394c;product=Possible secreted protein;protein_id=CCP43124.1;transl_table=11
AL123456.3	EMBL	gene	474940	475344	.	+	.	ID=gene-Rv0395;Name=Rv0395;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0395
AL123456.3	EMBL	CDS	474940	475344	.	+	0	ID=cds-CCP43125.1;Parent=gene-Rv0395;Dbxref=EnsemblGenomes-Gn:Rv0395,EnsemblGenomes-Tr:CCP43125,UniProtKB/TrEMBL:P95203,NCBI_GP:CCP43125.1;Name=CCP43125.1;Note=Rv0395%2C (MTCY04D9.07)%2C len: 134 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0395;product=Hypothetical protein;protein_id=CCP43125.1;transl_table=11
AL123456.3	EMBL	gene	475350	475742	.	+	.	ID=gene-Rv0396;Name=Rv0396;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0396
AL123456.3	EMBL	CDS	475350	475742	.	+	0	ID=cds-CCP43126.1;Parent=gene-Rv0396;Dbxref=EnsemblGenomes-Gn:Rv0396,EnsemblGenomes-Tr:CCP43126,UniProtKB/TrEMBL:P95204,NCBI_GP:CCP43126.1;Name=CCP43126.1;Note=Rv0396%2C (MTCY04D9.08)%2C len: 130 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0396;product=Hypothetical protein;protein_id=CCP43126.1;transl_table=11
AL123456.3	EMBL	gene	475816	476184	.	+	.	ID=gene-Rv0397;Name=Rv0397;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0397
AL123456.3	EMBL	CDS	475816	476184	.	+	0	ID=cds-CCP43127.1;Parent=gene-Rv0397;Dbxref=EnsemblGenomes-Gn:Rv0397,EnsemblGenomes-Tr:CCP43127,UniProtKB/TrEMBL:P95205,NCBI_GP:CCP43127.1;Name=CCP43127.1;Note=Rv0397%2C (MTCY04D9.09)%2C len: 122 aa. Part of 13E12 repeat family of conserved Mycobacterium tuberculosis proteins%2C similar to downstream Rv0393|Z84725|MTCY4D9_5 conserved 13E12 repeat family protein (441 aa)%2C FASTA scores: E(): 0%2C (87.7%25 identity in 122 aa overlap).;gbkey=CDS;locus_tag=Rv0397;product=Conserved 13E12 repeat family protein;protein_id=CCP43127.1;transl_table=11
AL123456.3	EMBL	gene	476394	476642	.	+	.	ID=gene-Rv0397A;Name=Rv0397A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0397A
AL123456.3	EMBL	CDS	476394	476642	.	+	0	ID=cds-CCP43128.1;Parent=gene-Rv0397A;Dbxref=EnsemblGenomes-Gn:Rv0397A,EnsemblGenomes-Tr:CCP43128,UniProtKB/TrEMBL:I6Y3N9,NCBI_GP:CCP43128.1;Name=CCP43128.1;Note=Rv0397A%2C len: 82 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0397A;product=Conserved protein;protein_id=CCP43128.1;transl_table=11
AL123456.3	EMBL	gene	476679	477320	.	-	.	ID=gene-Rv0398c;Name=Rv0398c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0398c
AL123456.3	EMBL	CDS	476679	477320	.	-	0	ID=cds-CCP43129.1;Parent=gene-Rv0398c;Dbxref=EnsemblGenomes-Gn:Rv0398c,EnsemblGenomes-Tr:CCP43129,GOA:P95206,UniProtKB/TrEMBL:P95206,NCBI_GP:CCP43129.1;Name=CCP43129.1;Note=Rv0398c%2C (MTCY04D9.10c)%2C len: 213 aa. Possible secreted protein%2C sharing no homology with other proteins. Has potential signal sequence with hydrophobic stretch from aa 7-25.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0398c;product=Possible secreted protein;protein_id=CCP43129.1;transl_table=11
AL123456.3	EMBL	gene	477327	478556	.	-	.	ID=gene-Rv0399c;Name=lpqK;gbkey=Gene;gene=lpqK;gene_biotype=protein_coding;locus_tag=Rv0399c
AL123456.3	EMBL	CDS	477327	478556	.	-	0	ID=cds-CCP43130.1;Parent=gene-Rv0399c;Dbxref=EnsemblGenomes-Gn:Rv0399c,EnsemblGenomes-Tr:CCP43130,GOA:P95207,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:P95207,NCBI_GP:CCP43130.1;Name=CCP43130.1;Note=Rv0399c%2C (MTCY04D9.11c)%2C len: 409 aa. Possible lpqK%2Cconserved lipoprotein%2C showing some similarity to penicillin binding proteins and various peptidases e.g. DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase protein (406 aa)%2C FASTA scores: opt: 348%2C E(): 5.6e-16%2C(29.2%25 identity in 301 aa overlap). Also similar to other Mycobacterium tuberculosis PBPs and esterases. Has possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqK;locus_tag=Rv0399c;product=Possible conserved lipoprotein LpqK;protein_id=CCP43130.1;transl_table=11
AL123456.3	EMBL	gene	478566	479753	.	-	.	ID=gene-Rv0400c;Name=fadE7;gbkey=Gene;gene=fadE7;gene_biotype=protein_coding;locus_tag=Rv0400c
AL123456.3	EMBL	CDS	478566	479753	.	-	0	ID=cds-CCP43131.1;Parent=gene-Rv0400c;Dbxref=EnsemblGenomes-Gn:Rv0400c,EnsemblGenomes-Tr:CCP43131,GOA:P95208,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P95208,NCBI_GP:CCP43131.1;Name=CCP43131.1;Note=Rv0400c%2C (MTCY04D9.12c)%2C len: 395 aa. Probable fadE7%2C acyl-CoA dehydrogenase%2C similar to many e.g. CAC12923.1|AL445403 putative acyl CoA dehydrogenase from Streptomyces coelicolor (397 aa)%3B G624219 glutaryl-CoA dehydrogenase precursor (438 aa)%2C FASTA scores: opt: 1161%2CE(): 0%2C (48.1%25 identity in 391 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE7;locus_tag=Rv0400c;product=Acyl-CoA dehydrogenase FadE7;protein_id=CCP43131.1;transl_table=11
AL123456.3	EMBL	gene	479789	480160	.	+	.	ID=gene-Rv0401;Name=Rv0401;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0401
AL123456.3	EMBL	CDS	479789	480160	.	+	0	ID=cds-CCP43132.1;Parent=gene-Rv0401;Dbxref=EnsemblGenomes-Gn:Rv0401,EnsemblGenomes-Tr:CCP43132,GOA:P95210,InterPro:IPR021414,UniProtKB/TrEMBL:P95210,NCBI_GP:CCP43132.1;Name=CCP43132.1;Note=Rv0401%2C (MTCY04D9.14)%2C len: 123 aa. Probable conserved transmembrane protein%2C equivalent to AL023514|MLCB4_9 putative integral membrane protein from Mycobacterium leprae (122 aa)%2C FASTA scores: opt: 548%2C E(): 4.4e-32%2C (66.9%25 identity in 121 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv0401;product=Probable conserved transmembrane protein;protein_id=CCP43132.1;transl_table=11
AL123456.3	EMBL	gene	480355	483231	.	-	.	ID=gene-Rv0402c;Name=mmpL1;gbkey=Gene;gene=mmpL1;gene_biotype=protein_coding;locus_tag=Rv0402c
AL123456.3	EMBL	CDS	480355	483231	.	-	0	ID=cds-CCP43133.1;Parent=gene-Rv0402c;Dbxref=EnsemblGenomes-Gn:Rv0402c,EnsemblGenomes-Tr:CCP43133,GOA:P9WJV9,InterPro:IPR004707,InterPro:IPR004869,NCBI_GP:CCP43133.1;Name=CCP43133.1;Note=Rv0402c%2C (MTCY04D9.15c)%2C len: 958 aa. Probable mmpL1%2C conserved transmembrane transport protein (see Tekaia et al.%2C 1999)%2C member of RND superfamily%2C highly similar to other Mycobacterial proteins e.g. YV34_MYCTU|Q11171 hypothetical 106.2 kDa membrane protein from Mycobacterium tuberculosis (968 aa)%2C FASTA scores: opt: 3551%2C E(): 0%2C (55.4%25 identity in 933aa overlap)%3B YV34_MYCLE|P54881 hypothetical 105.2 kDa protein from Mycobacterium leprae (959 aa)%2C FASTA scores: opt: 3615%2CE(): 0%2C (55.5%25 identity in 941 aa overlap)%3B etc. Highly similar to many other mycobacterial MmpL proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. Rv0450c%2C Rv0676c%2C Rv0507%2C etc. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL1;locus_tag=Rv0402c;product=Probable conserved transmembrane transport protein MmpL1;protein_id=CCP43133.1;transl_table=11
AL123456.3	EMBL	gene	483228	483656	.	-	.	ID=gene-Rv0403c;Name=mmpS1;gbkey=Gene;gene=mmpS1;gene_biotype=protein_coding;locus_tag=Rv0403c
AL123456.3	EMBL	CDS	483228	483656	.	-	0	ID=cds-CCP43134.1;Parent=gene-Rv0403c;Dbxref=EnsemblGenomes-Gn:Rv0403c,EnsemblGenomes-Tr:CCP43134,GOA:P9WJT5,InterPro:IPR008693,NCBI_GP:CCP43134.1;Name=CCP43134.1;Note=Rv0403c%2C (MTCY04D9.16c)%2C len: 142 aa. Probable mmpS1%2C conserved membrane protein (see citation below)%2Chighly similar to other Mycobacterial proteins e.g. YV33_MYCLE|P54880 hypothetical 16.9 kDa protein from Mycobacterium leprae (154 aa)%2C FASTA scores: opt: 458%2C E(): 1.6e-26%2C (46.9%25 identity in 143 aa overlap)%3B YV33_MYCTU|Q11170 hypothetical 15.9 kDa protein from Mycobacterium tuberculosis (147 aa)%2C FASTA scores: opt: 362%2C E(): 1.1e-19%2C (42.1%25 identity in 140 aa overlap)%3B etc. Also similar to other MmpS proteins from Mycobacterium tuberculosis e.g. Rv0677c%2C Rv0451c%2C etc. Belongs to the MmpS family. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpS1;locus_tag=Rv0403c;product=Probable conserved membrane protein MmpS1;protein_id=CCP43134.1;transl_table=11
AL123456.3	EMBL	gene	483977	485734	.	+	.	ID=gene-Rv0404;Name=fadD30;gbkey=Gene;gene=fadD30;gene_biotype=protein_coding;locus_tag=Rv0404
AL123456.3	EMBL	CDS	483977	485734	.	+	0	ID=cds-CCP43135.1;Parent=gene-Rv0404;Dbxref=EnsemblGenomes-Gn:Rv0404,EnsemblGenomes-Tr:CCP43135,GOA:P9WQ57,InterPro:IPR000873,NCBI_GP:CCP43135.1;Name=CCP43135.1;Note=Rv0404%2C (MTCY04D9.17-MTCY22G10.00)%2C len: 585 aa. fadD30%2C fatty-acid-AMP synthetase%2C similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa)%3B MASC_MYCLE|P54200 masc protein from Mycobacterium leprae (372 aa)%2C FASTA scores: opt: 888%2C E(): 0%2C (44.2%25 identity in 342 aa overlap). Also similar to Y06J_MYCTU|Q10976 hypothetical 67.9 kDa protein (626 aa)%2C FASTA scores: opt: 1463%2C E(): 0%2C (42.4%25 identity in 568 aa overlap).;gbkey=CDS;gene=fadD30;locus_tag=Rv0404;product=Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP43135.1;transl_table=11
AL123456.3	EMBL	gene	485731	489939	.	+	.	ID=gene-Rv0405;Name=pks6;gbkey=Gene;gene=pks6;gene_biotype=protein_coding;locus_tag=Rv0405
AL123456.3	EMBL	CDS	485731	489939	.	+	0	ID=cds-CCP43136.1;Parent=gene-Rv0405;Dbxref=EnsemblGenomes-Gn:Rv0405,EnsemblGenomes-Tr:CCP43136,GOA:O86335,InterPro:IPR001031,InterPro:IPR001227,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020802,InterPro:IPR020806,InterPro:IPR020841,InterPro:IPR029058,UniProtKB/TrEMBL:O86335,NCBI_GP:CCP43136.1;Name=CCP43136.1;Note=Rv0405%2C (MTCY22G10.01)%2C len: 1402 aa. Probable pks6%2Cmembrane-bound polyketide synthase (see citation below)%2Chighly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa)%3B Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa)%2CFASTA scores: opt: 2303%2C E(): 0%2C (38.7%25 identity in 1232 aa overlap)%3B etc. Contains PS00606 Beta-ketoacyl synthases active site%2C 2 x PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks6;inference=protein motif:PROSITE:PS00606;locus_tag=Rv0405;product=Probable membrane bound polyketide synthase Pks6;protein_id=CCP43136.1;transl_table=11
AL123456.3	EMBL	gene	489887	490705	.	-	.	ID=gene-Rv0406c;Name=Rv0406c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0406c
AL123456.3	EMBL	CDS	489887	490705	.	-	0	ID=cds-CCP43137.1;Parent=gene-Rv0406c;Dbxref=EnsemblGenomes-Gn:Rv0406c,EnsemblGenomes-Tr:CCP43137,GOA:O86336,InterPro:IPR001279,UniProtKB/TrEMBL:O86336,NCBI_GP:CCP43137.1;Name=CCP43137.1;Note=Rv0406c%2C (MTCY22G10.02c)%2C len: 272 aa. Beta-lactamase-like protein%2C equivalent to AAD38170.1|AF152397_1 beta-lactamase-like protein from Mycobacterium phlei (243 aa)%3B AL023514|MLCB4_8 hypothetical protein from Mycobacterium leprae (251 aa)%2C FASTA scores: opt: 1284%2C E(): 0%2C (74.9%25 identity in 243 aa overlap)%3B and AAD38164.1|AF152394_2 beta-lactamase-like protein from Mycobacterium avium (247 aa)%2C FASTA scores: opt: 1301%2C E(): 0%2C (74.2%25 identity in 244 aa overlap)%3B etc. Also slight similarity to others beta-lactamases and hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349 metallo-beta-lactamase L1 precursor (beta-lactamase%2C type II) (penicillinase) from Xanthomonas maltophilia (290 aa)%2CFASTA scores: (34.4%25 identity in 96 aa overlap). Recombinant protein has beta lactamase activity (See Nampoothiri et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0406c;product=Beta lactamase like protein;protein_id=CCP43137.1;transl_table=11
AL123456.3	EMBL	gene	490783	491793	.	+	.	ID=gene-Rv0407;Name=fgd1;gbkey=Gene;gene=fgd1;gene_biotype=protein_coding;gene_synonym=fgd;locus_tag=Rv0407
AL123456.3	EMBL	CDS	490783	491793	.	+	0	ID=cds-CCP43138.1;Parent=gene-Rv0407;Dbxref=EnsemblGenomes-Gn:Rv0407,EnsemblGenomes-Tr:CCP43138,GOA:P9WNE1,InterPro:IPR011251,InterPro:IPR019944,InterPro:IPR019945,PDB:3B4Y,PDB:3C8N,NCBI_GP:CCP43138.1;Name=CCP43138.1;Note=Rv0407%2C (MTCY22G10.03)%2C len: 336 aa. fgd1%2CF420-dependent glucose-6-phosphate dehydrogenase%2Cequivalent to others from Mycobacteria e.g. AAD38165.1|AF152394_3 from Mycobacterium avium (336 aa)%2CFASTA scores: opt: 2082%2C E(): 0%2C (89.9%25 identity in 336 aa overlap)%3B AL023514|MLCB 4_7 from Mycobacterium leprae (336 aa)%2C FASTA scores: opt: 2069%2C E(): 0%2C (89.0%25 identity in 336 aa overlap). Also similar to other dehydrogenases e.g. CAA77276.1|Y18730 F420-dependent alcohol dehydrogenase from Methanofollis liminatans (330 aa). Also similar to many proteins from Mycobacterium tuberculosis e.g. Rv0953c%2CRv0791c%2C etc. Note that previously known as fgd.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fgd1;locus_tag=Rv0407;product=F420-dependent glucose-6-phosphate dehydrogenase Fgd1;protein_id=CCP43138.1;transl_table=11
AL123456.3	EMBL	gene	491786	493858	.	+	.	ID=gene-Rv0408;Name=pta;gbkey=Gene;gene=pta;gene_biotype=protein_coding;locus_tag=Rv0408
AL123456.3	EMBL	CDS	491786	493858	.	+	0	ID=cds-CCP43139.1;Parent=gene-Rv0408;Dbxref=EnsemblGenomes-Gn:Rv0408,EnsemblGenomes-Tr:CCP43139,GOA:P9WHP1,InterPro:IPR002505,InterPro:IPR004614,InterPro:IPR010766,InterPro:IPR016475,InterPro:IPR027417,InterPro:IPR028979,NCBI_GP:CCP43139.1;Name=CCP43139.1;Note=Rv0408%2C (MTCY22G10.04)%2C len: 690 aa. Probable pta%2Cphosphate acetyltransferase%2C highly similar to others e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 phosphate acetyltransferase from Escherichia coli strain K12 (713 aa)%2C FASTA scores: opt: 1303%2C E(): 0%2C (38.0%25 identity in 718 aa overlap)%3B etc. Belongs to the phosphate acetyltransferase and butyryltransferase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pta;locus_tag=Rv0408;product=Probable phosphate acetyltransferase Pta (phosphotransacetylase);protein_id=CCP43139.1;transl_table=11
AL123456.3	EMBL	gene	493851	495008	.	+	.	ID=gene-Rv0409;Name=ackA;gbkey=Gene;gene=ackA;gene_biotype=protein_coding;locus_tag=Rv0409
AL123456.3	EMBL	CDS	493851	495008	.	+	0	ID=cds-CCP43140.1;Parent=gene-Rv0409;Dbxref=EnsemblGenomes-Gn:Rv0409,EnsemblGenomes-Tr:CCP43140,GOA:P9WQH1,InterPro:IPR000890,InterPro:IPR004372,InterPro:IPR023865,NCBI_GP:CCP43140.1;Name=CCP43140.1;Note=Rv0409%2C (MTCY22G10.05)%2C len: 385 aa. Probable ackA%2Cacetate kinase%2C highly similar to others e.g. ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis (395 aa)%2C FASTA scores: opt: 974%2C E(): 0%2C (43.5%25 identity in 393 aa overlap)%3B etc. Contains PS01075 Acetate and butyrate kinases family signature 1%2C PS00758 ArgE / dapE / ACY1/ CPG2 / yscS family signature 1. Belongs to the acetokinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ackA;inference=protein motif:PROSITE:PS01075;locus_tag=Rv0409;product=Probable acetate kinase AckA (acetokinase);protein_id=CCP43140.1;transl_table=11
AL123456.3	EMBL	gene	495062	497314	.	-	.	ID=gene-Rv0410c;Name=pknG;gbkey=Gene;gene=pknG;gene_biotype=protein_coding;locus_tag=Rv0410c
AL123456.3	EMBL	CDS	495062	497314	.	-	0	ID=cds-CCP43141.1;Parent=gene-Rv0410c;Dbxref=EnsemblGenomes-Gn:Rv0410c,EnsemblGenomes-Tr:CCP43141,GOA:P9WI73,InterPro:IPR000719,InterPro:IPR008271,InterPro:IPR011009,PDB:2PZI,NCBI_GP:CCP43141.1;Name=CCP43141.1;Note=Rv0410c%2C (MTCY22G10.06c)%2C len: 750 aa. PknG%2Cserine/threonine-protein kinase (see citations below)%2Cequivalent to PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 probable serine/threonine-protein kinase from Mycobacterium leprae (767 aa). Also similar to others e.g. AB76890.1|AL159139 putative serine/threonine protein kinase from Streptomyces coelicolor (774 aa)%3B etc. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases. Structure of PknG with inhibitor AX20017 reveals that the inhibitor-binding pocket is shaped by a unique set of amino acid side chains not found in any human kinase (See Scherr et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknG;inference=protein motif:PROSITE:PS00108;locus_tag=Rv0410c;product=Serine/threonine-protein kinase PknG (protein kinase G) (STPK G);protein_id=CCP43141.1;transl_table=11
AL123456.3	EMBL	gene	497314	498300	.	-	.	ID=gene-Rv0411c;Name=glnH;gbkey=Gene;gene=glnH;gene_biotype=protein_coding;locus_tag=Rv0411c
AL123456.3	EMBL	CDS	497314	498300	.	-	0	ID=cds-CCP43142.1;Parent=gene-Rv0411c;Dbxref=EnsemblGenomes-Gn:Rv0411c,EnsemblGenomes-Tr:CCP43142,GOA:P96257,InterPro:IPR001638,UniProtKB/TrEMBL:P96257,NCBI_GP:CCP43142.1;Name=CCP43142.1;Note=Rv0411c%2C (MTCY22G10.07c)%2C len: 328 aa. Probable glnH%2C glutamine-binding protein%2C membrane-bound lipoprotein (see citation below)%2C equivalent to AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 glutamine-binding protein homolog from Mycobacterium leprae (325 aa)%2C FASTA scores: opt: 1747%2C E(): 0%2C (79.3%25 identity in 328 aa overlap). Also similar to others e.g. GLNH_BACST|P27676 glutamine-binding protein precursor from Bacillus stearothermophilus (262 aa)%2C FASTA scores: opt: 493%2C E(): 7.5e-22%2C (37.8%25 identity in 193 aa overlap)%3B etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C PS01039 Bacterial extracellular solute-binding proteins%2C family 3 signature. Belongs to the bacterial extracellular solute-binding protein family 3. Presumed attached to the membrane by a lipid anchor.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnH;inference=protein motif:PROSITE:PS01039;locus_tag=Rv0411c;product=Probable glutamine-binding lipoprotein GlnH (GLNBP);protein_id=CCP43142.1;transl_table=11
AL123456.3	EMBL	gene	498300	499619	.	-	.	ID=gene-Rv0412c;Name=Rv0412c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0412c
AL123456.3	EMBL	CDS	498300	499619	.	-	0	ID=cds-CCP43143.1;Parent=gene-Rv0412c;Dbxref=EnsemblGenomes-Gn:Rv0412c,EnsemblGenomes-Tr:CCP43143,GOA:P96258,UniProtKB/TrEMBL:P96258,NCBI_GP:CCP43143.1;Name=CCP43143.1;Note=Rv0412c%2C (MTCY22G10.08c)%2C len: 439 aa. Possible conserved membrane protein%2C equivalent to AL035159|MLCB1450_16|T44737 probable membrane protein from Mycobacterium leprae (403 aa)%2C FASTA scores: opt: 2027%2CE(): 0%2C (80.4%25 identity in 403 aa overlap). Also some similarity with CAB71201.1|AL138538 putative secreted protein from Streptomyces coelicolor (429 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0412c;product=Possible conserved membrane protein;protein_id=CCP43143.1;transl_table=11
AL123456.3	EMBL	gene	499713	500366	.	+	.	ID=gene-Rv0413;Name=mutT3;gbkey=Gene;gene=mutT3;gene_biotype=protein_coding;locus_tag=Rv0413
AL123456.3	EMBL	CDS	499713	500366	.	+	0	ID=cds-CCP43144.1;Parent=gene-Rv0413;Dbxref=EnsemblGenomes-Gn:Rv0413,EnsemblGenomes-Tr:CCP43144,GOA:P9WIX9,InterPro:IPR000086,InterPro:IPR015797,InterPro:IPR020084,InterPro:IPR020476,NCBI_GP:CCP43144.1;Name=CCP43144.1;Note=Rv0413%2C (MTCY22G10.10)%2C len: 217 aa. Possible mutT3%2Cmutator protein (see citation below)%2C showing some similarity with e.g. MUTT_PROVU|P32090 mutator mutt protein from Proteus vulgaris (112 aa)%2C FASTA scores: opt: 151%2CE(): 0.0008%2C (40.7%25 identity in 59 aa overlap). Seems to belong to the NUDIX hydrolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mutT3;locus_tag=Rv0413;product=Possible mutator protein MutT3 (7%2C8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase);protein_id=CCP43144.1;transl_table=11
AL123456.3	EMBL	gene	500350	501018	.	-	.	ID=gene-Rv0414c;Name=thiE;gbkey=Gene;gene=thiE;gene_biotype=protein_coding;locus_tag=Rv0414c
AL123456.3	EMBL	CDS	500350	501018	.	-	0	ID=cds-CCP43145.1;Parent=gene-Rv0414c;Dbxref=EnsemblGenomes-Gn:Rv0414c,EnsemblGenomes-Tr:CCP43145,GOA:P9WG75,InterPro:IPR003733,InterPro:IPR013785,InterPro:IPR022998,PDB:3O63,NCBI_GP:CCP43145.1;Name=CCP43145.1;Note=Rv0414c%2C (MTCY22G10.11c)%2C len: 222 aa. thiE%2C thiamin phosphate pyrophosphorylase%2C equivalent to Q9ZBL5|AL035159|MLCB1450_17 probable thiamine-phosphate pyrophosphorylase from Mycobacterium leprae (235 aa)%2C FASTA scores: opt: 1095%2C E(): 0%2C (78.0%25 identity in 223 aa overlap). Also similar to others e.g. T34974|5689976|CAB52013.1|AL109663 probable thiamin phosphate pyrophosphorylase from Streptomyces coelicolor (223 aa)%3B THIE_ECOLI|P30137 thie protein from Escherichia coli strain K12 (211 aa)%2C FASTA scores: opt: 275%2C E(): 7.8e-12%2C (37.8%25 identity in 196 aa overlap)%3B etc. Belongs to the TMP-PPASE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thiE;locus_tag=Rv0414c;product=Thiamine-phosphate pyrophosphorylase ThiE (TMP pyrophosphorylase) (TMP-PPASE) (thiamine-phosphate synthase);protein_id=CCP43145.1;transl_table=11
AL123456.3	EMBL	gene	501148	502170	.	+	.	ID=gene-Rv0415;Name=thiO;gbkey=Gene;gene=thiO;gene_biotype=protein_coding;locus_tag=Rv0415
AL123456.3	EMBL	CDS	501148	502170	.	+	0	ID=cds-CCP43146.1;Parent=gene-Rv0415;Dbxref=EnsemblGenomes-Gn:Rv0415,EnsemblGenomes-Tr:CCP43146,GOA:P96261,InterPro:IPR006076,InterPro:IPR012727,UniProtKB/TrEMBL:P96261,NCBI_GP:CCP43146.1;Name=CCP43146.1;Note=Rv0415%2C (MTCY22G10.12)%2C len: 340 aa. Possible thiO%2Cthiamine biosynthesis oxidoreductase%2C equivalent to T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical protein from Mycobacterium leprae (340 aa)%2C FASTA scores: opt: 1867%2C E(): 0%2C (82.0%25 identity in 338 aa overlap). Shows some similarity to other thiO proteins e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis oxidoreductase from Rhizobium etli plasmid pb (327 aa) (see citation below)%3B AAG31046.1|AF264948_8|THIO putative amino acid oxidase flavoprotein ThiO from Erwinia amylovora (349 aa)%3B NP_106392.1|14025578|BAB52178.1|AP003007|THIO thiamine biosynthesis oxidoreductase THIO from Mesorhizobium loti (333 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thiO;locus_tag=Rv0415;product=Possible thiamine biosynthesis oxidoreductase ThiO;protein_id=CCP43146.1;transl_table=11
AL123456.3	EMBL	gene	502167	502373	.	+	.	ID=gene-Rv0416;Name=thiS;gbkey=Gene;gene=thiS;gene_biotype=protein_coding;locus_tag=Rv0416
AL123456.3	EMBL	CDS	502167	502373	.	+	0	ID=cds-CCP43147.1;Parent=gene-Rv0416;Dbxref=EnsemblGenomes-Gn:Rv0416,EnsemblGenomes-Tr:CCP43147,GOA:P96262,InterPro:IPR003749,InterPro:IPR010035,InterPro:IPR012675,InterPro:IPR016155,UniProtKB/TrEMBL:P96262,NCBI_GP:CCP43147.1;Name=CCP43147.1;Note=Rv0416%2C (MTCY22G10.13)%2C len: 68 aa. Possible thiS protein%2C equivalent to T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 hypothetical protein from Mycobacterium leprae (74 aa)%2C FASTA scores: opt: 303%2C E(): 2e-18%2C (71.6%25 identity in 74 aa overlap). Shows weak similarity with O32583|THIS_ECOLI|THIG1|B3991.1 this protein from Escherichia coli strain K12 (66 aa)%2CFASTA scores: opt: 103%2C E(): 0.052%2C (30.9%25 identity in 68 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=thiS;locus_tag=Rv0416;product=Possible protein ThiS;protein_id=CCP43147.1;transl_table=11
AL123456.3	EMBL	gene	502366	503124	.	+	.	ID=gene-Rv0417;Name=thiG;gbkey=Gene;gene=thiG;gene_biotype=protein_coding;locus_tag=Rv0417
AL123456.3	EMBL	CDS	502366	503124	.	+	0	ID=cds-CCP43148.1;Parent=gene-Rv0417;Dbxref=EnsemblGenomes-Gn:Rv0417,EnsemblGenomes-Tr:CCP43148,GOA:P9WG73,InterPro:IPR008867,InterPro:IPR013785,NCBI_GP:CCP43148.1;Name=CCP43148.1;Note=Rv0417%2C (MTCY22G10.14)%2C len: 252 aa. Probable thiG%2Cthiamin biosynthesis protein%2C equivalent to AL035159|MLCB1450_20|T44741|THIG probable thiamin biosynthesis protein from Mycobacterium leprae (261 aa)%2CFASTA scores: opt: 1380%2C E(): 0%2C (86.8%25 identity in 250 aa overlap). Also highly similar to others e.g. SCOEDB|SC6E10.03|T35490|THIG probable thiazole biosynthesis protein from Streptomyces coelicolor (264 aa)%3B F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG thiamin biosynthesis protein thiG from Xylella fastidiosa (275 aa)%3B P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089.1|U00006 THIG protein thiamin biosynthesis protein from Escherichia coli strain K-12 (281 aa)%3B etc. Belongs to the THIG family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thiG;locus_tag=Rv0417;product=Probable thiamin biosynthesis protein ThiG (thiazole biosynthesis protein);protein_id=CCP43148.1;transl_table=11
AL123456.3	EMBL	gene	503496	504998	.	+	.	ID=gene-Rv0418;Name=lpqL;gbkey=Gene;gene=lpqL;gene_biotype=protein_coding;locus_tag=Rv0418
AL123456.3	EMBL	CDS	503496	504998	.	+	0	ID=cds-CCP43149.1;Parent=gene-Rv0418;Dbxref=EnsemblGenomes-Gn:Rv0418,EnsemblGenomes-Tr:CCP43149,GOA:P96264,InterPro:IPR003137,InterPro:IPR007484,UniProtKB/TrEMBL:P96264,NCBI_GP:CCP43149.1;Name=CCP43149.1;Note=Rv0418%2C (MTCCY22G10.15)%2C len: 500 aa. Probable lpqL%2Clipoprotein aminopeptidase%2C similar to others e.g. B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939 probable aminopeptidase from Pseudomonas aeruginosa (536 aa)%3B P80561|APX_STRGR|SGAP|S66427 aminopeptidase from Streptomyces griseus (284 aa) (homology only with C-terminus of Rv0418)%3B P37302|APE3_YEAST|1077010|A54134 aminopeptidase Y from Saccharomyces cerevisiae (537 aa)%3B etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqL;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0418;product=Probable lipoprotein aminopeptidase LpqL;protein_id=CCP43149.1;transl_table=11
AL123456.3	EMBL	gene	505086	506582	.	+	.	ID=gene-Rv0419;Name=lpqM;gbkey=Gene;gene=lpqM;gene_biotype=protein_coding;locus_tag=Rv0419
AL123456.3	EMBL	CDS	505086	506582	.	+	0	ID=cds-CCP43150.1;Parent=gene-Rv0419;Dbxref=EnsemblGenomes-Gn:Rv0419,EnsemblGenomes-Tr:CCP43150,UniProtKB/TrEMBL:P96265,NCBI_GP:CCP43150.1;Name=CCP43150.1;Note=Rv0419%2C (MTCY22G10.16)%2C len: 498 aa. Possible lpqM%2Clipoprotein peptidase %3B has potential N-terminal signal peptide and contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqM;inference=protein motif:PROSITE:PS00142;locus_tag=Rv0419;product=Possible lipoprotein peptidase LpqM;protein_id=CCP43150.1;transl_table=11
AL123456.3	EMBL	gene	506561	506971	.	-	.	ID=gene-Rv0420c;Name=Rv0420c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0420c
AL123456.3	EMBL	CDS	506561	506971	.	-	0	ID=cds-CCP43151.1;Parent=gene-Rv0420c;Dbxref=EnsemblGenomes-Gn:Rv0420c,EnsemblGenomes-Tr:CCP43151,GOA:P96266,UniProtKB/TrEMBL:P96266,NCBI_GP:CCP43151.1;Name=CCP43151.1;Note=Rv0420c%2C (MTCY22G10.17c)%2C len: 136 aa. Possible transmembrane protein%3B has potential transmembrane domains aa 53-99 and aa 100-122.;gbkey=CDS;locus_tag=Rv0420c;product=Possible transmembrane protein;protein_id=CCP43151.1;transl_table=11
AL123456.3	EMBL	gene	507132	507761	.	-	.	ID=gene-Rv0421c;Name=Rv0421c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0421c
AL123456.3	EMBL	CDS	507132	507761	.	-	0	ID=cds-CCP43152.1;Parent=gene-Rv0421c;Dbxref=EnsemblGenomes-Gn:Rv0421c,EnsemblGenomes-Tr:CCP43152,GOA:P96267,InterPro:IPR026555,InterPro:IPR029058,InterPro:IPR029059,UniProtKB/TrEMBL:P96267,NCBI_GP:CCP43152.1;Name=CCP43152.1;Note=Rv0421c%2C (MTCY22G10.18c)%2C len: 209 aa. Conserved hypothetical protein%2C showing similarity with NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical protein from Mesorhizobium loti (214 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0421c;product=Conserved hypothetical protein;protein_id=CCP43152.1;transl_table=11
AL123456.3	EMBL	gene	507758	508555	.	-	.	ID=gene-Rv0422c;Name=thiD;gbkey=Gene;gene=thiD;gene_biotype=protein_coding;locus_tag=Rv0422c
AL123456.3	EMBL	CDS	507758	508555	.	-	0	ID=cds-CCP43153.1;Parent=gene-Rv0422c;Dbxref=EnsemblGenomes-Gn:Rv0422c,EnsemblGenomes-Tr:CCP43153,GOA:P9WG77,InterPro:IPR004399,InterPro:IPR013749,InterPro:IPR029056,NCBI_GP:CCP43153.1;Name=CCP43153.1;Note=Rv0422c%2C (MTCY22G10.19c)%2C len: 265 aa. Probable thiD%2C phosphomethylpyrimidine kinase%2C equivalent to AL035159|MLCB1450_21 phosphomethylpyrimidine kinase from Mycobacterium leprae (279 aa)%2C FASTA scores: opt: 1386%2CE(): 0%2C (77.8%25 identity in 266 aa overlap). Also highly similar to others e.g. HIU32725_3|P44697|THID_HAEIN phosphomethylpyrimidine kinase from Haemophilus influenzae (269 aa)%2C FASTA scores: opt: 605%2C E(): 0%2C (42.1%25 identity in 259 aa overlap). Belongs to the ThiD family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thiD;locus_tag=Rv0422c;product=Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase);protein_id=CCP43153.1;transl_table=11
AL123456.3	EMBL	gene	508582	510225	.	-	.	ID=gene-Rv0423c;Name=thiC;gbkey=Gene;gene=thiC;gene_biotype=protein_coding;locus_tag=Rv0423c
AL123456.3	EMBL	CDS	508582	510225	.	-	0	ID=cds-CCP43154.1;Parent=gene-Rv0423c;Dbxref=EnsemblGenomes-Gn:Rv0423c,EnsemblGenomes-Tr:CCP43154,GOA:P9WG79,InterPro:IPR002817,InterPro:IPR025747,NCBI_GP:CCP43154.1;Name=CCP43154.1;Note=Rv0423c%2C (MTCY22G10.20c)%2C len: 547 aa. Probable thiC%2C thiamin biosynthesis protein%2C equivalent to Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 thiamine biosynthesis protein from Mycobacterium leprae (547 aa)%2C FASTA scores: opt: 3283%2C E(): 0%2C (90.1%25 identity in 547 aa overlap). Also highly similar to others e.g. P45740|THIC_BACSU thiamin biosynthesis protein from Bacillus subtilis (590 aa)%2C FASTA scores: opt: 2295%2C E(): 0%2C (65.2%25 identity in 580 aa overlap)%3B P30136|THIC_ECOLI THIC protein from Escherichia coli strain K12 (631 aa)%2CFASTA scores: opt: 2141%2C E(): 0%2C (62.1%25 identity in 568 aa overlap)%3B etc. Belongs to the ThiC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thiC;locus_tag=Rv0423c;product=Probable thiamine biosynthesis protein ThiC;protein_id=CCP43154.1;transl_table=11
AL123456.3	EMBL	gene	510377	510652	.	-	.	ID=gene-Rv0424c;Name=Rv0424c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0424c
AL123456.3	EMBL	CDS	510377	510652	.	-	0	ID=cds-CCP43155.1;Parent=gene-Rv0424c;Dbxref=EnsemblGenomes-Gn:Rv0424c,EnsemblGenomes-Tr:CCP43155,UniProtKB/TrEMBL:P96270,NCBI_GP:CCP43155.1;Name=CCP43155.1;Note=Rv0424c%2C (MTCY22G10.21c)%2C len: 91 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0424c;product=Hypothetical protein;protein_id=CCP43155.1;transl_table=11
AL123456.3	EMBL	gene	510702	515321	.	-	.	ID=gene-Rv0425c;Name=ctpH;gbkey=Gene;gene=ctpH;gene_biotype=protein_coding;locus_tag=Rv0425c
AL123456.3	EMBL	CDS	510702	515321	.	-	0	ID=cds-CCP43156.1;Parent=gene-Rv0425c;Dbxref=EnsemblGenomes-Gn:Rv0425c,EnsemblGenomes-Tr:CCP43156,GOA:P96271,InterPro:IPR001757,InterPro:IPR006068,InterPro:IPR008250,InterPro:IPR023214,InterPro:IPR023298,InterPro:IPR023299,UniProtKB/TrEMBL:P96271,NCBI_GP:CCP43156.1;Name=CCP43156.1;Note=Rv0425c%2C (MTCY22G10.22c)%2C len: 1539 aa. Possible ctpH%2C metal cation-transporting P-type ATPase (transmembrane protein)%2C showing some similarity with CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative cation-transporting ATPase from Mycobacterium leprae (1609 aa). Also similar to others ATPases e.g. AE000873_1 cation-transporting P-ATPase from Methanobacterium thermoautotrop (844 aa)%2C FASTA score: (30.5%25 identity in 827 aa overlap)%3B AB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa)%3B etc. C-terminal region similar to other ATPases from Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative cation-transporting ATPase C (855 aa)%2C FASTA scores: opt: 770%2C E(): 5.3e-32%2C (44.9%25 identity in 820 aa overlap). Nucleotide position 511518 in the genome sequence has been corrected%2C T:G resulting in I1268I.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpH;locus_tag=Rv0425c;product=Possible metal cation transporting P-type ATPase CtpH;protein_id=CCP43156.1;transl_table=11
AL123456.3	EMBL	gene	515373	515816	.	-	.	ID=gene-Rv0426c;Name=Rv0426c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0426c
AL123456.3	EMBL	CDS	515373	515816	.	-	0	ID=cds-CCP43157.1;Parent=gene-Rv0426c;Dbxref=EnsemblGenomes-Gn:Rv0426c,EnsemblGenomes-Tr:CCP43157,GOA:P96272,UniProtKB/TrEMBL:P96272,NCBI_GP:CCP43157.1;Name=CCP43157.1;Note=Rv0426c%2C (MTCY22G10.23c)%2C len: 147 aa. Possible transmembrane protein%3B has potential transmembrane domains aa 19-41%2C and aa 61-83.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0426c;product=Possible transmembrane protein;protein_id=CCP43157.1;transl_table=11
AL123456.3	EMBL	gene	516017	516892	.	-	.	ID=gene-Rv0427c;Name=xthA;gbkey=Gene;gene=xthA;gene_biotype=protein_coding;gene_synonym=xth;locus_tag=Rv0427c
AL123456.3	EMBL	CDS	516017	516892	.	-	0	ID=cds-CCP43158.1;Parent=gene-Rv0427c;Dbxref=EnsemblGenomes-Gn:Rv0427c,EnsemblGenomes-Tr:CCP43158,GOA:P96273,InterPro:IPR004808,InterPro:IPR005135,UniProtKB/TrEMBL:P96273,NCBI_GP:CCP43158.1;Name=CCP43158.1;Note=Rv0427c%2C (MTCY22G10.24c)%2C len: 291 aa. Probable xthA (alternate gene name: xth)%2C exodeoxyribonuclease III protein (see citation below)%2C similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa)%2C FASTA scores: opt: 360%2C E(): 1.2e-17%2C (29.3%25 identity in 270 aa overlap)%3B etc. Belongs to the AP/EXOA family of DNA repair enzymes.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=xthA;locus_tag=Rv0427c;product=Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI);protein_id=CCP43158.1;transl_table=11
AL123456.3	EMBL	gene	516895	517803	.	-	.	ID=gene-Rv0428c;Name=Rv0428c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0428c
AL123456.3	EMBL	CDS	516895	517803	.	-	0	ID=cds-CCP43159.1;Parent=gene-Rv0428c;Dbxref=EnsemblGenomes-Gn:Rv0428c,EnsemblGenomes-Tr:CCP43159,GOA:P96274,UniProtKB/TrEMBL:P96274,NCBI_GP:CCP43159.1;Name=CCP43159.1;Note=Rv0428c%2C (MTCY22G10.25c)%2C len: 302 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0428c;product=GCN5-related N-acetyltransferase;protein_id=CCP43159.1;transl_table=11
AL123456.3	EMBL	gene	517803	518396	.	-	.	ID=gene-Rv0429c;Name=def;gbkey=Gene;gene=def;gene_biotype=protein_coding;locus_tag=Rv0429c
AL123456.3	EMBL	CDS	517803	518396	.	-	0	ID=cds-CCP43160.1;Parent=gene-Rv0429c;Dbxref=EnsemblGenomes-Gn:Rv0429c,EnsemblGenomes-Tr:CCP43160,GOA:P9WIJ3,InterPro:IPR000181,InterPro:IPR023635,PDB:3E3U,NCBI_GP:CCP43160.1;Name=CCP43160.1;Note=Rv0429c%2C (MTCY22G10.26c)%2C len: 197 aa. Probable def%2Cpolypeptide deformylase%2C equivalent to CAC30884.1|AL583923 polypeptide deformylase from Mycobacterium leprae (197 aa). Also similar to others e.g. DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from Escherichia coli (169 aa)%2CFASTA scores: opt: 179%2C E(): 1.8e-05%2C (34.6%25 identity in 162 aa overlap)%3B etc. Belongs to the polypeptide deformylase family. Cofactor: binds 1 zinc ion.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=def;locus_tag=Rv0429c;product=Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase);protein_id=CCP43160.1;transl_table=11
AL123456.3	EMBL	gene	518733	519041	.	+	.	ID=gene-Rv0430;Name=Rv0430;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0430
AL123456.3	EMBL	CDS	518733	519041	.	+	0	ID=cds-CCP43161.1;Parent=gene-Rv0430;Dbxref=EnsemblGenomes-Gn:Rv0430,EnsemblGenomes-Tr:CCP43161,GOA:P96276,InterPro:IPR021678,UniProtKB/TrEMBL:P96276,NCBI_GP:CCP43161.1;Name=CCP43161.1;Note=Rv0430%2C (MTCY22G10.27)%2C len: 102 aa. Conserved hypothetical protein%2C equivalent to AC30882.1|AL583923 conserved hypothetical protein from Mycobacterium leprae (102 aa). Also highly similar to CAB93047.1|SCD95A.20|AL357432 hypothetical protein from Streptomyces coelicolor (84 aa).;gbkey=CDS;locus_tag=Rv0430;product=Conserved hypothetical protein;protein_id=CCP43161.1;transl_table=11
AL123456.3	EMBL	gene	519073	519567	.	+	.	ID=gene-Rv0431;Name=Rv0431;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0431
AL123456.3	EMBL	CDS	519073	519567	.	+	0	ID=cds-CCP43162.1;Parent=gene-Rv0431;Dbxref=EnsemblGenomes-Gn:Rv0431,EnsemblGenomes-Tr:CCP43162,GOA:P96277,InterPro:IPR027381,UniProtKB/TrEMBL:P96277,NCBI_GP:CCP43162.1;Name=CCP43162.1;Note=Rv0431%2C (MTCY22G10.28)%2C len: 164 aa. Putative tuberculin related peptide%3B almost identical to D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis (172 aa)%2C FASTA score: (99.4%25 identity in 163 aa overlap). Highly similar to to CAC30881.1|AL583923 tuberculin related peptide (AT103) from Mycobacterium leprae (167 aa). Some similarity to G550415|HRPC (282 aa)%2C FASTA scores: opt: 120%2C E(): 0.36%2C (33.3%25 identity in 111 aa overlap). Potential transmembrane domain at aa 19-37.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0431;product=Putative tuberculin related peptide;protein_id=CCP43162.1;transl_table=11
AL123456.3	EMBL	gene	519600	520322	.	+	.	ID=gene-Rv0432;Name=sodC;gbkey=Gene;gene=sodC;gene_biotype=protein_coding;locus_tag=Rv0432
AL123456.3	EMBL	CDS	519600	520322	.	+	0	ID=cds-CCP43163.1;Parent=gene-Rv0432;Dbxref=EnsemblGenomes-Gn:Rv0432,EnsemblGenomes-Tr:CCP43163,GOA:P9WGE9,InterPro:IPR001424,InterPro:IPR018152,PDB:1PZS,NCBI_GP:CCP43163.1;Name=CCP43163.1;Note=Rv0432%2C (MTCY22G10.29)%2C len: 240 aa. sodC%2Cperiplasmic superoxide dismutase [Cu-Zn]%2C equivalent to CAC30880.1|AL583923 superoxide dismutase precursor (Cu-Zn) from Mycobacterium leprae (240 aa)%3B and AAK20038.1|AF326234_1 copper zinc superoxide dismutase from Mycobacterium avium subsp. paratuberculosis (226 aa). Also similar to others e.g. SODC_PHOLE|P00446 superoxide dismutase precursor (Cu-Zn) from Photobacterium leiognathi (173 aa)%2C FASTA scores: opt: 214%2C E(): 5.2 e-06%2C (36.5%25 identity in 181 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Belongs to the Cu-Zn superoxide dismutase family. Possibly localized in periplasm%2C membrane-bound.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sodC;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0432;product=Periplasmic superoxide dismutase [Cu-Zn] SodC;protein_id=CCP43163.1;transl_table=11
AL123456.3	EMBL	gene	520324	521454	.	+	.	ID=gene-Rv0433;Name=Rv0433;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0433
AL123456.3	EMBL	CDS	520324	521454	.	+	0	ID=cds-CCP43164.1;Parent=gene-Rv0433;Dbxref=EnsemblGenomes-Gn:Rv0433,EnsemblGenomes-Tr:CCP43164,GOA:P9WPK9,InterPro:IPR006336,InterPro:IPR011793,NCBI_GP:CCP43164.1;Name=CCP43164.1;Note=Rv0433%2C (MTCY22G10.30)%2C len: 376 aa. Conserved hypothetical protein%2C similar to other hypothetical proteins e.g. P77213|YBDK_ECOLI hypothetical 41.7 KD protein from Escherichia coli strain K12 (372 aa)%2C FASTA scores: opt: 555%2C E(): 2e-30%2C (28.2%25 identity in 365 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0433;product=Conserved hypothetical protein;protein_id=CCP43164.1;transl_table=11
AL123456.3	EMBL	gene	521514	522167	.	+	.	ID=gene-Rv0434;Name=Rv0434;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0434
AL123456.3	EMBL	CDS	521514	522167	.	+	0	ID=cds-CCP43165.1;Parent=gene-Rv0434;Dbxref=EnsemblGenomes-Gn:Rv0434,EnsemblGenomes-Tr:CCP43165,GOA:P96280,InterPro:IPR003111,InterPro:IPR015947,InterPro:IPR027065,UniProtKB/TrEMBL:P96280,NCBI_GP:CCP43165.1;Name=CCP43165.1;Note=Rv0434%2C (MTCY22G10.31)%2C len: 217 aa. Conserved hypothetical protein%2C similar to AE002052_2 from Deinococcus radiodurans (213 aa)%2C FASTA scores: opt: 258%2CE(): 4e-10%2C (31.9%25 identity in 213 aa overlap)%3B SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from Synechocystis (214 aa)%2C FASTA scores: opt: 156%2C E(): 0.00041%2C (28.4%25 identity in 204 aa overlap)%3B MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2 from Myxococcus xanthus (826 aa)%2C FASTA scores: opt: 160%2CE(): 0.00068%2C (28.4%25 identity in 197 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0434;product=Conserved hypothetical protein;protein_id=CCP43165.1;transl_table=11
AL123456.3	EMBL	gene	522347	524533	.	-	.	ID=gene-Rv0435c;Name=Rv0435c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0435c
AL123456.3	EMBL	CDS	522347	524533	.	-	0	ID=cds-CCP43166.1;Parent=gene-Rv0435c;Dbxref=EnsemblGenomes-Gn:Rv0435c,EnsemblGenomes-Tr:CCP43166,GOA:P96281,InterPro:IPR003338,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR003960,InterPro:IPR009010,InterPro:IPR027417,UniProtKB/TrEMBL:P96281,NCBI_GP:CCP43166.1;Name=CCP43166.1;Note=Rv0435c%2C (MTCY22G10.32c)%2C len: 728 aa. Putative conserved ATPase%2C similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocaldarius (780 aa)%2C FASTA scores: opt: 897%2C E(): 0%2C(34.5%25 identity in 693 aa overlap)%3B NP_148637.1|7435761|B72479 transitional endoplasmic reticulum ATPase from Aeropyrum pernix (699 aa)%3B etc. Also similar to Rv3610c and Rv2115c from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00674 AAA-protein family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00674;locus_tag=Rv0435c;product=Putative conserved ATPase;protein_id=CCP43166.1;transl_table=11
AL123456.3	EMBL	gene	524530	525390	.	-	.	ID=gene-Rv0436c;Name=pssA;gbkey=Gene;gene=pssA;gene_biotype=protein_coding;locus_tag=Rv0436c
AL123456.3	EMBL	CDS	524530	525390	.	-	0	ID=cds-CCP43167.1;Parent=gene-Rv0436c;Dbxref=EnsemblGenomes-Gn:Rv0436c,EnsemblGenomes-Tr:CCP43167,GOA:P9WPG1,InterPro:IPR000462,InterPro:IPR004533,NCBI_GP:CCP43167.1;Name=CCP43167.1;Note=Rv0436c%2C (MTCY22G10.33c)%2C len: 286 aa. Probable pssA%2C PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (see citation below)%2C integral membrane protein%2C equivalent to AL035159|MLCB1450_9|T44730 from Mycobacterium leprae (300 aa)%2C FASTA scores: opt: 1506%2C E(): 0%2C (77.9%25 identity in 285 aa overlap). Also highly similar to others e.g. NP_108059.1|14027250|BAB54204.1|AP003012 phosphatidylserine synthase from Mesorhizobium loti (248 aa)%3B PSS_BACSU|P39823 cdp-diacylglycerol--serine o-phosphatidyltransferase from Bacillus subtilis (177 aa)%2C FASTA scores: opt: 277%2C E(): 9.9e-12%2C (33.3%25 identity in 183 aa overlap)%3B etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pssA;inference=protein motif:PROSITE:PS00379;locus_tag=Rv0436c;product=Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase);protein_id=CCP43167.1;transl_table=11
AL123456.3	EMBL	gene	525387	526082	.	-	.	ID=gene-Rv0437c;Name=psd;gbkey=Gene;gene=psd;gene_biotype=protein_coding;locus_tag=Rv0437c
AL123456.3	EMBL	CDS	525387	526082	.	-	0	ID=cds-CCP43168.1;Parent=gene-Rv0437c;Dbxref=EnsemblGenomes-Gn:Rv0437c,EnsemblGenomes-Tr:CCP43168,GOA:P9WHQ5,InterPro:IPR003817,NCBI_GP:CCP43168.1;Name=CCP43168.1;Note=Rv0437c%2C (MTV037.01c)%2C len: 231 aa (start uncertain). Possible psd%2C phosphatidylserine decarboxylase %2C equivalent to CAC29819.1|AL583918 conserved hypothetical protein from Mycobacterium leprae (243 aa)%3B and highly similar to MLCB1450.11|T44729|4154044|CAA22695.1|AL035159 hypothetical protein from Mycobacterium leprae (202 aa)%2CFASTA score: (74.6%25 identity in 197 aa overlap). Also similar to other phosphatidylserine decarboxylases e.g. NP_108058.1|14027249|BAB54203.1|AP003012 phosphatidylserine decarboxylase from Mesorhizobium loti (232 aa)%3B AAK86872|g15156090|AGR_C_1963 phosphatidylserine decarboxylase from Agrobacterium tumefaciens (244 aa)%3B AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase from Chlorobium tepidum (216 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=psd;locus_tag=Rv0437c;product=Possible phosphatidylserine decarboxylase Psd (PS decarboxylase);protein_id=CCP43168.1;transl_table=11
AL123456.3	EMBL	gene	526143	527360	.	-	.	ID=gene-Rv0438c;Name=moeA2;gbkey=Gene;gene=moeA2;gene_biotype=protein_coding;gene_synonym=moeA3;locus_tag=Rv0438c
AL123456.3	EMBL	CDS	526143	527360	.	-	0	ID=cds-CCP43169.1;Parent=gene-Rv0438c;Dbxref=EnsemblGenomes-Gn:Rv0438c,EnsemblGenomes-Tr:CCP43169,GOA:P9WJQ5,InterPro:IPR001453,InterPro:IPR005110,InterPro:IPR005111,InterPro:IPR020817,NCBI_GP:CCP43169.1;Name=CCP43169.1;Note=Rv0438c%2C (MTV037.02c)%2C len: 405 aa. Probable moeA2%2Cmolybdenum cofactor biosynthesis protein%2C highly similar to many e.g. Y10817|ANY10817_2 from A. nicotinovorans (429 aa)%2C FASTA scores: opt: 786%2C E(): 0%2C (39.2%25 identity in 398 aa overlap)%3B etc. Also similar to MOEA1|Rv0994|MTCI237.08|O05577 probable molybdopterin biosynthesis protein from Mycobacterium tuberculosis (426 aa)%2C FASTA scores: opt: 667%2C E(): 2e-32%2C (36.5%25 identity in 425 aa overlap). Note that previously known as moeA3.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moeA2;locus_tag=Rv0438c;product=Probable molybdopterin biosynthesis protein MoeA2;protein_id=CCP43169.1;transl_table=11
AL123456.3	EMBL	gene	527379	528314	.	-	.	ID=gene-Rv0439c;Name=Rv0439c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0439c
AL123456.3	EMBL	CDS	527379	528314	.	-	0	ID=cds-CCP43170.1;Parent=gene-Rv0439c;Dbxref=EnsemblGenomes-Gn:Rv0439c,EnsemblGenomes-Tr:CCP43170,GOA:O53726,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O53726,NCBI_GP:CCP43170.1;Name=CCP43170.1;Note=Rv0439c%2C (MTV037.03c)%2C len: 311 aa. Probable dehydrogenase/reductase%2C equivalent to AL035159|MLCB1450_6|T44727 probable oxidoreductase from Mycobacterium leprae (304 aa)%2C FASTA scores: opt: 1360%2CE(): 0%2C (69.2%25 identity in 302 aa overlap). Also highly similar to various oxidoreductases%2C generally dehydrogenases/reductases e.g. PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 probable short chain dehydrogenase from Pseudomonas aeruginosa (309 aa)%3B Q03326|OXIR_STRAT probable oxidoreductase from Streptomyces antibioticus (298 aa)%2CFASTA scores: opt: 400%2C E(): 1.2e-18%2C (34.6%25 identity in 298 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0439c;product=Probable dehydrogenase/reductase;protein_id=CCP43170.1;transl_table=11
AL123456.3	EMBL	gene	528608	530230	.	+	.	ID=gene-Rv0440;Name=groEL2;gbkey=Gene;gene=groEL2;gene_biotype=protein_coding;gene_synonym=groEL-2,groL2,hsp60,hsp65;locus_tag=Rv0440
AL123456.3	EMBL	CDS	528608	530230	.	+	0	ID=cds-CCP43171.1;Parent=gene-Rv0440;Dbxref=EnsemblGenomes-Gn:Rv0440,EnsemblGenomes-Tr:CCP43171,GOA:P9WPE7,InterPro:IPR001844,InterPro:IPR002423,InterPro:IPR018370,InterPro:IPR027409,InterPro:IPR027413,PDB:1SJP,PDB:3RTK,NCBI_GP:CCP43171.1;Name=CCP43171.1;Note=Rv0440%2C (MTV037.04)%2C len: 540 aa. GroEL2 (alternate gene names: groL2%2C groEL-2%2C hsp65%2C hsp60)%2C 60 kDa chaperonin 2 (see Shinnick 1987). Purified 65 kDa antigen can elicit a strong delayed-type hypersensitivity reaction in experimental animals infected with M. tuberculosis. This protein is one of the major immunoreactive proteins of the mycobacteria. This antigen contains epitopes that are common to various species of mycobacteria. Contains PS00296 Chaperonins cpn60 signature. Belongs to the chaperonin (HSP60) family. Phosphorylated in vitro by PknJ|Rv2088 (See Arora et al.%2C 2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=groEL2;inference=protein motif:PROSITE:PS00296;locus_tag=Rv0440;product=60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (antigen A);protein_id=CCP43171.1;transl_table=11
AL123456.3	EMBL	gene	530296	530724	.	-	.	ID=gene-Rv0441c;Name=Rv0441c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0441c
AL123456.3	EMBL	CDS	530296	530724	.	-	0	ID=cds-CCP43172.1;Parent=gene-Rv0441c;Dbxref=EnsemblGenomes-Gn:Rv0441c,EnsemblGenomes-Tr:CCP43172,GOA:P9WKW3,InterPro:IPR012349,InterPro:IPR020145,NCBI_GP:CCP43172.1;Name=CCP43172.1;Note=Rv0441c%2C (MTV037.05c)%2C len: 142 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0441c;product=Hypothetical protein;protein_id=CCP43172.1;transl_table=11
AL123456.3	EMBL	gene	530751	532214	.	-	.	ID=gene-Rv0442c;Name=PPE10;gbkey=Gene;gene=PPE10;gene_biotype=protein_coding;locus_tag=Rv0442c
AL123456.3	EMBL	CDS	530751	532214	.	-	0	ID=cds-CCP43173.1;Parent=gene-Rv0442c;Dbxref=EnsemblGenomes-Gn:Rv0442c,EnsemblGenomes-Tr:CCP43173,GOA:P9WI41,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP43173.1;Name=CCP43173.1;Note=Rv0442c%2C (MTV037.06c)%2C len: 487 aa. PPE10%2C Member of the Mycobacterium tuberculosis PPE family%2C nearly identical to hypothetical protein from Mycobacterium tuberculosis (strain Erdman) and to AN5S46909_1 protein fragment from Mycobacterium bovis (302 aa)%3B P42611|YHS6_MYCTU hypothetical 50.6 kDa protein (517 aa)%2C FASTA scores: opt: 3144%2C E(): 0%2C (98.4 identity in 492 aa overlap)%3B and S46909|S46909_1 (302 aa)%2C FASTA scores: opt: 1897%2C E(): 0%2C(98.0%25 identity in 302 aa overlap). Nucleotide position 532097 in the genome sequence has been corrected%2C T:C resulting in K40E.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE10;locus_tag=Rv0442c;product=PPE family protein PPE10;protein_id=CCP43173.1;transl_table=11
AL123456.3	EMBL	gene	532396	532911	.	+	.	ID=gene-Rv0443;Name=Rv0443;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0443
AL123456.3	EMBL	CDS	532396	532911	.	+	0	ID=cds-CCP43174.1;Parent=gene-Rv0443;Dbxref=EnsemblGenomes-Gn:Rv0443,EnsemblGenomes-Tr:CCP43174,InterPro:IPR007061,InterPro:IPR027369,UniProtKB/TrEMBL:O53728,NCBI_GP:CCP43174.1;Name=CCP43174.1;Note=Rv0443%2C (MTV037.07)%2C len: 171 aa. Conserved protein%2Chighly similar to AL049863|SC5H1_23|T35339 hypothetical protein from Streptomyces coelicolor (171 aa)%2C FASTA scores: opt: 561%2C E(): 2.3e-32%2C (49.7%25 identity in 165 aa overlap)%3B and CAC42482.1|AJ318385 hypothetical protein from Amycolatopsis mediterranei (163 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0443;product=Conserved protein;protein_id=CCP43174.1;transl_table=11
AL123456.3	EMBL	gene	533091	533789	.	-	.	ID=gene-Rv0444c;Name=rskA;gbkey=Gene;gene=rskA;gene_biotype=protein_coding;locus_tag=Rv0444c
AL123456.3	EMBL	CDS	533091	533789	.	-	0	ID=cds-CCP43175.1;Parent=gene-Rv0444c;Dbxref=EnsemblGenomes-Gn:Rv0444c,EnsemblGenomes-Tr:CCP43175,GOA:P9WGX5,InterPro:IPR018764,PDB:4NQW,NCBI_GP:CCP43175.1;Name=CCP43175.1;Note=Rv0444c%2C (MTV037.08c)%2C len: 232 aa. RskA%2C regulator of SigK (See Said-Salim et al.%2C 2006)%3B C-terminus similar to P12752|Y24K_STRGR hypothetical 24.7 kDa protein from Streptomyces griseus (238 aa)%2C FASTA scores: opt: 207%2C E(): 2.2e-05%2C (32.9%25 identity in 158 aa overlap). Cleaved by Rip|Rv2869c%2C in M. tuberculosis Erdman (See Sklar et al.%2C2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rskA;locus_tag=Rv0444c;product=Anti-sigma factor RskA (regulator of sigma K);protein_id=CCP43175.1;transl_table=11
AL123456.3	EMBL	gene	533833	534396	.	-	.	ID=gene-Rv0445c;Name=sigK;gbkey=Gene;gene=sigK;gene_biotype=protein_coding;locus_tag=Rv0445c
AL123456.3	EMBL	CDS	533833	534396	.	-	0	ID=cds-CCP43176.1;Parent=gene-Rv0445c;Dbxref=EnsemblGenomes-Gn:Rv0445c,EnsemblGenomes-Tr:CCP43176,GOA:P9WGH7,InterPro:IPR007627,InterPro:IPR007630,InterPro:IPR011991,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,PDB:4NQW,NCBI_GP:CCP43176.1;Name=CCP43176.1;Note=Rv0445c%2C (MTV037.09c)%2C len: 187 aa. sigK%2Calternative RNA polymerase sigma factor (see citations below)%2C highly similar to others e.g. 5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase sigma factor from Streptomyces coelicolor (185 aa)%3B NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase sigma factor from Mesorhizobium loti (179 aa)%3B 1654108|AAB17906.1|U11283|A58883 probable transcription initiation factor sigma E from Rhodobacter phaeroides (168 aa)%2C FASTA scores: opt: 299%2C E(): 2e-14%2C (32.7%25 identity in 168 aa overlap)%3B Q45585|SIGW_BACSU RNA polymerase sigma factor SIGW from Bacillus subtilis (187 aa)%2C FASTA scores: opt: 213%2C E(): 2.9e-08%2C (26.8%25 identity in 179 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigK;locus_tag=Rv0445c;product=Alternative RNA polymerase sigma factor SigK;protein_id=CCP43176.1;transl_table=11
AL123456.3	EMBL	gene	534445	535215	.	-	.	ID=gene-Rv0446c;Name=Rv0446c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0446c
AL123456.3	EMBL	CDS	534445	535215	.	-	0	ID=cds-CCP43177.1;Parent=gene-Rv0446c;Dbxref=EnsemblGenomes-Gn:Rv0446c,EnsemblGenomes-Tr:CCP43177,GOA:O53731,InterPro:IPR001104,InterPro:IPR010721,UniProtKB/TrEMBL:O53731,NCBI_GP:CCP43177.1;Name=CCP43177.1;Note=Rv0446c%2C (MTV037.10c)%2C len: 256 aa. Possible conserved transmembrane protein%2C similar at N-terminus to U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 aa)%2C FASTA scores: opt: 175%2C E(): 2.5e-05%2C (62.5%25 identity in 40 aa overlap)%3B and at C-terminus to AL021529|SC10A5_3 from Streptomyces coelicolor (226 aa)%2C FASTA scores: opt: 207%2C E(): 9.8e-07%2C (34.2%25 identity in 114 aa overlap). Also similar to others hypothetical proteins e.g. AAK04680.1|AE006291_14|AE006291 hypothetical protein from Lactococcus lactis subsp. lactis (257 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0446c;product=Possible conserved transmembrane protein;protein_id=CCP43177.1;transl_table=11
AL123456.3	EMBL	gene	535224	536507	.	-	.	ID=gene-Rv0447c;Name=ufaA1;gbkey=Gene;gene=ufaA1;gene_biotype=protein_coding;locus_tag=Rv0447c
AL123456.3	EMBL	CDS	535224	536507	.	-	0	ID=cds-CCP43178.1;Parent=gene-Rv0447c;Dbxref=EnsemblGenomes-Gn:Rv0447c,EnsemblGenomes-Tr:CCP43178,GOA:O53732,InterPro:IPR003333,InterPro:IPR029063,UniProtKB/TrEMBL:O53732,NCBI_GP:CCP43178.1;Name=CCP43178.1;Note=Rv0447c%2C (MTV037.11c)%2C len: 427 aa (start uncertain). Probable ufaA1%2Ccyclopropane-fatty-acyl-phospholipid synthase%2C similar to others e.g. NP_102178.1|14021351|BAB47964.1|AP002994 cyclopropane-fatty-acyl-phospholipid synthase from Mesorhizobium loti (378 aa)%3B B82240|9655593|AAF94281.1|AE004192 cyclopropane-fatty-acyl-phospholipid synthase from Vibrio cholerae (432 aa)%3B P30010|CFA_ECOLI cyclopropane-fatty-acyl-phospholipid synthase from Escherichia coli strain K-12 (382 aa)%3B X55704|PPLPD_3 LPD-3 from P.putida (394 aa)%2C FASTA scores: opt: 556%2C E(): 2.8e-30%2C (33.3%25 identity in 387 aa overlap)%3B AE0005|HPAE000557_9 from Helicobacter pylori (389 aa)%2CFASTA scores: opt: 539%2C E(): 3.9e-29%2C (34.3%25 identity in 382 aa overlap).;gbkey=CDS;gene=ufaA1;locus_tag=Rv0447c;product=Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase);protein_id=CCP43178.1;transl_table=11
AL123456.3	EMBL	gene	536504	537169	.	-	.	ID=gene-Rv0448c;Name=Rv0448c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0448c
AL123456.3	EMBL	CDS	536504	537169	.	-	0	ID=cds-CCP43179.1;Parent=gene-Rv0448c;Dbxref=EnsemblGenomes-Gn:Rv0448c,EnsemblGenomes-Tr:CCP43179,InterPro:IPR010775,UniProtKB/TrEMBL:O53733,NCBI_GP:CCP43179.1;Name=CCP43179.1;Note=Rv0448c%2C (MTV037.12c)%2C len: 221 aa. Conserved hypothetical protein%2C similar to other hypothetical proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa)%2CFASTA scores: opt: 257%2C E(): 1.4e-10%2C (32.0%25 identity in 197 aa overlap)%3B etc. Some similarity to U15183|MLU15183_38 from Mycobacterium leprae (82 aa)%2C FASTA scores: opt: 134%2CE(): 0.014%2C (71.0%25 identity in 31 aa overlap).;gbkey=CDS;locus_tag=Rv0448c;product=Conserved hypothetical protein;protein_id=CCP43179.1;transl_table=11
AL123456.3	EMBL	gene	537229	538548	.	-	.	ID=gene-Rv0449c;Name=Rv0449c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0449c
AL123456.3	EMBL	CDS	537229	538548	.	-	0	ID=cds-CCP43180.1;Parent=gene-Rv0449c;Dbxref=EnsemblGenomes-Gn:Rv0449c,EnsemblGenomes-Tr:CCP43180,GOA:O53734,InterPro:IPR002937,UniProtKB/TrEMBL:O53734,NCBI_GP:CCP43180.1;Name=CCP43180.1;Note=Rv0449c%2C (MTV037.13c)%2C len: 439 aa. Conserved hypothetical protein%2C some similarity with several hypothetical proteins and various enzymes e.g. AAK24569.1|AE005927 amine oxidase%2C flavin-containing from Caulobacter crescentus (454 aa)%3B BAB02771.1|AB023036 mycolic acid methyl transferase-like protein from Arabidopsis thaliana (842 aa)%3B BAB01742.1|AP000374 protein which contains similarity to cyclopropane fatty acid synthase from Arabidopsis thaliana (793 aa)%3B etc. Has hydrophobic stretch at N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0449c;product=Conserved hypothetical protein;protein_id=CCP43180.1;transl_table=11
AL123456.3	EMBL	gene	538588	541491	.	-	.	ID=gene-Rv0450c;Name=mmpL4;gbkey=Gene;gene=mmpL4;gene_biotype=protein_coding;locus_tag=Rv0450c
AL123456.3	EMBL	CDS	538588	541491	.	-	0	ID=cds-CCP43181.1;Parent=gene-Rv0450c;Dbxref=EnsemblGenomes-Gn:Rv0450c,EnsemblGenomes-Tr:CCP43181,GOA:P9WJV3,InterPro:IPR004707,InterPro:IPR004869,NCBI_GP:CCP43181.1;Name=CCP43181.1;Note=Rv0450c%2C (MTV037.14c)%2C len: 967 aa. Probable mmpL4%2Cconserved transmembrane transport protein (see citations below)%2C member of RND superfamily%2C equivalent to U1740V|P54881|YV34_MYCLE hypothetical 105.2 kDa protein from Mycobacterium leprae (959 aa)%2C FASTA scores: opt: 5051%2C E(): 0%2C (78.4%25 identity in 962 aa overlap). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. Z83860|MTCY98.08 (962 aa)%2C FASTA scores: opt: 3917%2C E(): 0%2C (61.3%25 identity in 950 aa overlap)%2CMTCY20G9.34%2C etc. Contains PS00211 ABC transporters family signature. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL4;inference=protein motif:PROSITE:PS00211;locus_tag=Rv0450c;product=Probable conserved transmembrane transport protein MmpL4;protein_id=CCP43181.1;transl_table=11
AL123456.3	EMBL	gene	541488	541910	.	-	.	ID=gene-Rv0451c;Name=mmpS4;gbkey=Gene;gene=mmpS4;gene_biotype=protein_coding;locus_tag=Rv0451c
AL123456.3	EMBL	CDS	541488	541910	.	-	0	ID=cds-CCP43182.1;Parent=gene-Rv0451c;Dbxref=EnsemblGenomes-Gn:Rv0451c,EnsemblGenomes-Tr:CCP43182,GOA:P9WJS9,InterPro:IPR008693,PDB:2LW3,NCBI_GP:CCP43182.1;Name=CCP43182.1;Note=Rv0451c%2C (MTV037.15c)%2C len: 140 aa. Probable mmpS4%2Cconserved membrane protein (see citations below)%2Cequivalent to U1740W|P54880|YV33_MYCLE hypothetical 16.9 kDa protein from Mycobacterium leprae (154 aa)%2C FASTA scores: opt: 727%2C E(): 0%2C (75.9%25 identity in 137 aa overlap). Also similar to other Mycobacterial proteins e.g. Z84725|MTCY04D9.16c from Mycobacterium tuberculosis (142 aa)%2C FASTA scores: opt: 451%2C E(): 3.2e-24%2C (50.0%25 identity in 138 aa overlap)%3B etc. Belongs to the MmpS family. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpS4;locus_tag=Rv0451c;product=Probable conserved membrane protein MmpS4;protein_id=CCP43182.1;transl_table=11
AL123456.3	EMBL	gene	542142	542852	.	+	.	ID=gene-Rv0452;Name=Rv0452;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0452
AL123456.3	EMBL	CDS	542142	542852	.	+	0	ID=cds-CCP43183.1;Parent=gene-Rv0452;Dbxref=EnsemblGenomes-Gn:Rv0452,EnsemblGenomes-Tr:CCP43183,GOA:O53737,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:O53737,NCBI_GP:CCP43183.1;Name=CCP43183.1;Note=Rv0452%2C (MTV037.16)%2C len: 236 aa. Possible transcriptional regulator%2C similar to several putative TetR-family transcriptional regulators from Streptomyces coelicolor. Also similar in N-terminus to U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67 aa)%2C FASTA score: (76.1%25 identity in 67 aa overlap). Contains probable helix-turn-helix motif at aa 44-65 (Score 1727%2C +5.07 SD).;gbkey=CDS;locus_tag=Rv0452;product=Possible transcriptional regulatory protein;protein_id=CCP43183.1;transl_table=11
AL123456.3	EMBL	gene	543174	544730	.	+	.	ID=gene-Rv0453;Name=PPE11;gbkey=Gene;gene=PPE11;gene_biotype=protein_coding;locus_tag=Rv0453
AL123456.3	EMBL	CDS	543174	544730	.	+	0	ID=cds-CCP43184.1;Parent=gene-Rv0453;Dbxref=EnsemblGenomes-Gn:Rv0453,EnsemblGenomes-Tr:CCP43184,GOA:P9WI39,InterPro:IPR000030,NCBI_GP:CCP43184.1;Name=CCP43184.1;Note=Rv0453%2C (MTV037.17)%2C len: 518 aa. PPE11%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to many e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434 aa)%2C FASTA scores: opt: 882%2C E(): 7e-31%2C (41.8%25 identity in 514 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE11;locus_tag=Rv0453;product=PPE family protein PPE11;protein_id=CCP43184.1;transl_table=11
AL123456.3	EMBL	gene	544835	545185	.	+	.	ID=gene-Rv0454;Name=Rv0454;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0454
AL123456.3	EMBL	CDS	544835	545185	.	+	0	ID=cds-CCP43185.1;Parent=gene-Rv0454;Dbxref=EnsemblGenomes-Gn:Rv0454,EnsemblGenomes-Tr:CCP43185,UniProtKB/TrEMBL:O86364,NCBI_GP:CCP43185.1;Name=CCP43185.1;Note=Rv0454%2C (MTV037.18)%2C len: 116 aa (start uncertain). Conserved hypothetical protein%2C showing similarity with AAA63007.1|U15183 hypothetical protein from Mycobacterium leprae (115 aa)%2C FASTA scores: opt: 151%2C E(): 0.0019%2C(31.5%25 identity in 89 aa overlap).;gbkey=CDS;locus_tag=Rv0454;product=Conserved hypothetical protein;protein_id=CCP43185.1;transl_table=11
AL123456.3	EMBL	gene	545375	545821	.	-	.	ID=gene-Rv0455c;Name=Rv0455c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0455c
AL123456.3	EMBL	CDS	545375	545821	.	-	0	ID=cds-CCP43186.1;Parent=gene-Rv0455c;Dbxref=EnsemblGenomes-Gn:Rv0455c,EnsemblGenomes-Tr:CCP43186,GOA:O53740,InterPro:IPR021357,UniProtKB/TrEMBL:O53740,NCBI_GP:CCP43186.1;Name=CCP43186.1;Note=Rv0455c%2C (MTV037.19c)%2C len: 148 aa. Conserved protein%2C equivalent to CAC31896.1|AL583925 possible secreted protein from Mycobacterium leprae (153 aa). Has hydrophobic stretch at N-terminus. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0455c;product=Conserved protein;protein_id=CCP43186.1;transl_table=11
AL123456.3	EMBL	gene	545889	546803	.	-	.	ID=gene-Rv0456c;Name=echA2;gbkey=Gene;gene=echA2;gene_biotype=protein_coding;locus_tag=Rv0456c
AL123456.3	EMBL	CDS	545889	546803	.	-	0	ID=cds-CCP43187.1;Parent=gene-Rv0456c;Dbxref=EnsemblGenomes-Gn:Rv0456c,EnsemblGenomes-Tr:CCP43187,GOA:O07179,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,UniProtKB/TrEMBL:O07179,NCBI_GP:CCP43187.1;Name=CCP43187.1;Note=Rv0456c%2C (MTCI429A.02%2C MTV037.20c)%2C len: 304 aa. Probable echA2%2C enoyl-CoA hydratase%2C similar to other enoyl-CoA hydratases e.g. Q13011 peroxisomal enoyl-CoA hydratase-like protein (328 aa)%2C FASTA scores: opt: 209%2CE(): 5.3e-07%2C (31.7%25 identity in 142 aa overlap). Also similar to several other proteins from Mycobacterium tuberculosis e.g. MTCY09F9.29 FASTA score: (32.9%25 identity in 146 aa overlap)%3B and MTI376.01c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA2;locus_tag=Rv0456c;product=enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43187.1;transl_table=11
AL123456.3	EMBL	gene	547076	547357	.	-	.	ID=gene-Rv0456A;Name=mazF1;gbkey=Gene;gene=mazF1;gene_biotype=protein_coding;gene_synonym=mt2;locus_tag=Rv0456A
AL123456.3	EMBL	CDS	547076	547357	.	-	0	ID=cds-CCP43188.1;Parent=gene-Rv0456A;Dbxref=EnsemblGenomes-Gn:Rv0456A,EnsemblGenomes-Tr:CCP43188,GOA:Q6MX40,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP43188.1;Name=CCP43188.1;Note=Rv0456A%2C len: 93 aa. Possible mazF1%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv0456B (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%3B N-terminus highly similar to N-terminal part of P71650|Rv2801c|MT2869|MTCY16B7.42 conserved hypothetical protein from Mycobacterium tuberculosis (118 aa)%2C FASTA scores: opt: 303%2C E(): 1e-14%2C(60.44%25 identity in 91 aa overlap). Also some similarity in part with other hypothetical proteins e.g. Q9PHH8|XFA0027 Plasmid maintenance protein from Xylella fastidiosa (108 aa)%2C FASTA scores: opt: 169%2C E(): 3.9e-05%2C (50.820%25 identity in 61 aa overlap).;gbkey=CDS;gene=mazF1;locus_tag=Rv0456A;product=Possible toxin MazF1;protein_id=CCP43188.1;transl_table=11
AL123456.3	EMBL	gene	547344	547517	.	-	.	ID=gene-Rv0456B;Name=mazE1;gbkey=Gene;gene=mazE1;gene_biotype=protein_coding;locus_tag=Rv0456B
AL123456.3	EMBL	CDS	547344	547517	.	-	0	ID=cds-CCP43189.1;Parent=gene-Rv0456B;Dbxref=EnsemblGenomes-Gn:Rv0456B,EnsemblGenomes-Tr:CCP43189,NCBI_GP:CCP43189.1;Name=CCP43189.1;Note=Rv0456B%2C len: 57 aa. Possible mazE1%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv0456A (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006).;gbkey=CDS;gene=mazE1;locus_tag=Rv0456B;product=Possible antitoxin MazE1;protein_id=CCP43189.1;transl_table=11
AL123456.3	EMBL	repeat_region	547488	547517	.	-	.	ID=id-Rv0456B;Note=3 copies of a 10 bp near-perfect direct repeat%2CATTACTACCTATTACTACGTATTACTATCT;gbkey=repeat_region;gene=mazE1;locus_tag=Rv0456B
AL123456.3	EMBL	gene	547586	549607	.	-	.	ID=gene-Rv0457c;Name=Rv0457c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0457c
AL123456.3	EMBL	CDS	547586	549607	.	-	0	ID=cds-CCP43190.1;Parent=gene-Rv0457c;Dbxref=EnsemblGenomes-Gn:Rv0457c,EnsemblGenomes-Tr:CCP43190,GOA:O07178,InterPro:IPR001375,InterPro:IPR002470,InterPro:IPR023302,InterPro:IPR029058,UniProtKB/TrEMBL:O07178,NCBI_GP:CCP43190.1;Name=CCP43190.1;Note=Rv0457c%2C (MTCI429A.01%2C MTV038.01c)%2C len: 673 aa. Probable peptidase%2C similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 aa)%3B Y4NA_RHISN|P55577 probable peptidase (726 aa)%2C FASTA scores: opt: 1126%2C E(): 0%2C (40.9%25 identity in 491 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY369.26 FASTA score: (33.8%25 identity in 299 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0457c;product=Probable peptidase;protein_id=CCP43190.1;transl_table=11
AL123456.3	EMBL	gene	549675	551198	.	+	.	ID=gene-Rv0458;Name=Rv0458;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0458
AL123456.3	EMBL	CDS	549675	551198	.	+	0	ID=cds-CCP43191.1;Parent=gene-Rv0458;Dbxref=EnsemblGenomes-Gn:Rv0458,EnsemblGenomes-Tr:CCP43191,GOA:P9WNY1,InterPro:IPR015590,InterPro:IPR016160,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR029510,NCBI_GP:CCP43191.1;Name=CCP43191.1;Note=Rv0458%2C (MTV038.02)%2C len: 507 aa. Probable aldehyde dehydrogenase%2C highly similar to many%2C closest to P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase from Rhodococcus erythropolis (506 aa)%2C FASTA scores: opt: 2767%2C E(): 0%2C (79.7%25 identity in 507 aa overlap)%3B AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa)%2C FASTA scores: opt: 2563%2C E(): 0%2C (75.4%25 identity in 492 aa overlap)%3B Q9RJZ6|DHAL_STRCO probable aldehyde dehydrogenase from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in Mycobacterium tuberculosis e.g. Rv0768%2C Rv2858c. Belongs to the aldehyde dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0458;product=Probable aldehyde dehydrogenase;protein_id=CCP43191.1;transl_table=11
AL123456.3	EMBL	gene	551198	551689	.	+	.	ID=gene-Rv0459;Name=Rv0459;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0459
AL123456.3	EMBL	CDS	551198	551689	.	+	0	ID=cds-CCP43192.1;Parent=gene-Rv0459;Dbxref=EnsemblGenomes-Gn:Rv0459,EnsemblGenomes-Tr:CCP43192,InterPro:IPR008497,UniProtKB/TrEMBL:O53744,NCBI_GP:CCP43192.1;Name=CCP43192.1;Note=Rv0459%2C (MTV038.03)%2C len: 163 aa. Conserved hypothetical protein%2C highly similar to other hypothetical proteins. Note that highly similar to products of unidentified ORFs in Xanthobacter autotrophicus%2C AF029733_2 (139 aa)%2C and Rhodococcus erythropolis%2C REREUTP BC_1 (186 aa). Like MTV038.03%2C these ORF's are linked to aldehyde dehydrogenase genes. FASTA scores: AF0297|AF029733_2 (139 aa)%2C opt: 439%2C E(): 6.2e-24%2C (50.0%25 identity in 126 aa overlap)%3B and L24492|REREUTPBC_1 (186 aa)%2C opt: 347%2C E(): 2.1e-17%2C (52.7%25 identity in 169 aa overlap). N-terminus also highly similar to AAA63041.1|U15183 ethanolamine permease (eutP) match from Mycobacterium leprae (53 aa).;gbkey=CDS;locus_tag=Rv0459;product=Conserved hypothetical protein;protein_id=CCP43192.1;transl_table=11
AL123456.3	EMBL	gene	551749	551988	.	+	.	ID=gene-Rv0460;Name=Rv0460;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0460
AL123456.3	EMBL	CDS	551749	551988	.	+	0	ID=cds-CCP43193.1;Parent=gene-Rv0460;Dbxref=EnsemblGenomes-Gn:Rv0460,EnsemblGenomes-Tr:CCP43193,UniProtKB/TrEMBL:O53745,NCBI_GP:CCP43193.1;Name=CCP43193.1;Note=Rv0460%2C (MTV038.04)%2C len: 79 aa. Conserved hydrophobic protein%2C highly similar AAA63024.1|U15183 hypothetical protein from Mycobacterium leprae (56 aa)%2CFASTA scores: opt: 197%2C E(): 3.7e-09%2C (63.8%25 identity in 47 aa overlap).;gbkey=CDS;locus_tag=Rv0460;product=Conserved hydrophobic protein;protein_id=CCP43193.1;transl_table=11
AL123456.3	EMBL	gene	552026	552550	.	+	.	ID=gene-Rv0461;Name=Rv0461;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0461
AL123456.3	EMBL	CDS	552026	552550	.	+	0	ID=cds-CCP43194.1;Parent=gene-Rv0461;Dbxref=EnsemblGenomes-Gn:Rv0461,EnsemblGenomes-Tr:CCP43194,GOA:I6X961,UniProtKB/TrEMBL:I6X961,NCBI_GP:CCP43194.1;Name=CCP43194.1;Note=Rv0461%2C (MTV038.05)%2C len: 174 aa (start uncertain). Probable transmembrane protein. Nucleotide position 552085 in the genome sequence has been corrected%2C A:G resulting in Q20Q.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0461;product=Probable transmembrane protein;protein_id=CCP43194.1;transl_table=11
AL123456.3	EMBL	gene	552614	554008	.	+	.	ID=gene-Rv0462;Name=lpdC;gbkey=Gene;gene=lpdC;gene_biotype=protein_coding;gene_synonym=CIP50,TB49.2;locus_tag=Rv0462
AL123456.3	EMBL	CDS	552614	554008	.	+	0	ID=cds-CCP43195.1;Parent=gene-Rv0462;Dbxref=EnsemblGenomes-Gn:Rv0462,EnsemblGenomes-Tr:CCP43195,GOA:P9WHH9,InterPro:IPR001327,InterPro:IPR004099,InterPro:IPR006258,InterPro:IPR012999,InterPro:IPR013027,InterPro:IPR016156,InterPro:IPR023753,PDB:2A8X,PDB:3II4,PDB:4M52,NCBI_GP:CCP43195.1;Name=CCP43195.1;Note=Rv0462%2C (MTV038.06)%2C len: 464 aa. LpdC (alternate gene name: TB49.2%2C CIP50)%2C dihydrolipoamide dehydrogenase (see Argyrou %26 Blanchard 2001)%2C equivalent to AAA63016.1|U15183 lipoamide dehydrogenase from Mycobacterium leprae (467 aa)%2C FASTA scores: opt: 2583%2CE(): 0%2C (83.1%25 identity in 467 aa overlap). Also similar to to many e.g. P50970|DLDH_ZYMMO|X82291|ZMLPD_1 dihydrolipoamide dehydrogenase from Z.mobilis (466 aa)%2CFASTA scores: opt: 1198%2C E(): 0%2C (42.4 %25 identity in 465 aa overlap)%3B etc. Belongs to the pyridine nucleotide-disulfide oxidoreductases class-I. Binds to coronin-1 in BCG and M. tuberculosis - coronin-1 is retained on phagosomes and phagosome maturation is arrested (See Deghmane et al.%2C2007). LpdC|Rv0462 co-immunoprecipitates with DlaT|Rv2215 (in lpdC|Rv0462 mutant) and with BkdC|Rv2495c (in dlaT|Rv2215 mutant) (See Venugopal et al.%2C 2011).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpdC;locus_tag=Rv0462;product=Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase);protein_id=CCP43195.1;transl_table=11
AL123456.3	EMBL	gene	554016	554309	.	+	.	ID=gene-Rv0463;Name=Rv0463;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0463
AL123456.3	EMBL	CDS	554016	554309	.	+	0	ID=cds-CCP43196.1;Parent=gene-Rv0463;Dbxref=EnsemblGenomes-Gn:Rv0463,EnsemblGenomes-Tr:CCP43196,UniProtKB/TrEMBL:O53748,NCBI_GP:CCP43196.1;Name=CCP43196.1;Note=Rv0463%2C (MTV038.07)%2C len: 97 aa. Probable conserved transmembrane protein%2C highly similar to AAA63017.1|U15183 hypothetical protein from Mycobacterium leprae (101 aa)%2CFASTA scores: opt: 364%2C E(): 4e-21%2C (57.9%25 identity in 95 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv0463;product=Probable conserved membrane protein;protein_id=CCP43196.1;transl_table=11
AL123456.3	EMBL	gene	554313	554885	.	-	.	ID=gene-Rv0464c;Name=Rv0464c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0464c
AL123456.3	EMBL	CDS	554313	554885	.	-	0	ID=cds-CCP43197.1;Parent=gene-Rv0464c;Dbxref=EnsemblGenomes-Gn:Rv0464c,EnsemblGenomes-Tr:CCP43197,GOA:O53749,InterPro:IPR003779,InterPro:IPR029032,UniProtKB/TrEMBL:O53749,NCBI_GP:CCP43197.1;Name=CCP43197.1;Note=Rv0464c%2C (MTV038.08c)%2C len: 190 aa. Conserved protein%2C highly similar to CAC31982.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (188 aa). Also some similarity with Rv1531|AL022000|MTV045_5|D70820 hypothetical protein from Mycobacterium tuberculosis (188 aa)%2C FASTA scores: E(): 9.6e-10%2C (30.9%25 identity in 175 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0464c;product=Conserved protein;protein_id=CCP43197.1;transl_table=11
AL123456.3	EMBL	gene	554882	556306	.	-	.	ID=gene-Rv0465c;Name=Rv0465c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0465c
AL123456.3	EMBL	CDS	554882	556306	.	-	0	ID=cds-CCP43198.1;Parent=gene-Rv0465c;Dbxref=EnsemblGenomes-Gn:Rv0465c,EnsemblGenomes-Tr:CCP43198,GOA:P9WMI1,InterPro:IPR001387,InterPro:IPR010359,InterPro:IPR010982,InterPro:IPR018653,InterPro:IPR026281,NCBI_GP:CCP43198.1;Name=CCP43198.1;Note=Rv0465c%2C (MTV038.09c)%2C len: 474 aa. Probable transcriptional regulator%2C highly similar to AC44331.1|AL596102 putative DNA-binding protein from Streptomyces coelicolor (489 aa)%3B and similar to several hypothetical proteins and others transcriptional regulators. Some similarity in N-terminal region (1-100 aa) with repressors e.g. P06153|RPC_BPPH1 immunity repressor protein (144 aa)%2C FASTA scores: opt: 130%2C E(): 0.084%2C(27.0%25 identity in 100 aa overlap). Very similar to Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium tuberculosis (486 aa)%2C FASTA scores: opt: 1475%2C E(): 0%2C (47.4%25 identity in 468 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (1827%2C +5.41 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0465c;product=Probable transcriptional regulatory protein;protein_id=CCP43198.1;transl_table=11
AL123456.3	EMBL	gene	556458	557252	.	+	.	ID=gene-Rv0466;Name=Rv0466;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0466
AL123456.3	EMBL	CDS	556458	557252	.	+	0	ID=cds-CCP43199.1;Parent=gene-Rv0466;Dbxref=EnsemblGenomes-Gn:Rv0466,EnsemblGenomes-Tr:CCP43199,GOA:O53751,InterPro:IPR002864,InterPro:IPR029069,UniProtKB/TrEMBL:O53751,NCBI_GP:CCP43199.1;Name=CCP43199.1;Note=Rv0466%2C (MTV038.10)%2C len: 264 aa. Conserved protein%2Cequivalent to CAC31980.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (264 aa). Similar to Rv2001|Z74025|MTCY39.17c hypothetical 28.7 KDA protein from Mycobacterium tuberculosis (250 aa)%2C FASTA scores: opt: 592%2C E(): 0%2C (38.0%25 identity in 263 aa overlap). Some similarity to several thioesterases e.g. Q42561|ATACPTE17_1 acyl-(acyl carrier protein) thioester from A. thaliana (362 aa)%2C FASTA scores: E(): 0.0092%2C (24.4%25 identity in 197 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0466;product=Conserved protein;protein_id=CCP43199.1;transl_table=11
AL123456.3	EMBL	gene	557527	558813	.	+	.	ID=gene-Rv0467;Name=icl1;gbkey=Gene;gene=icl1;gene_biotype=protein_coding;gene_synonym=aceA,icl;locus_tag=Rv0467
AL123456.3	EMBL	CDS	557527	558813	.	+	0	ID=cds-CCP43200.1;Parent=gene-Rv0467;Dbxref=EnsemblGenomes-Gn:Rv0467,EnsemblGenomes-Tr:CCP43200,GOA:P9WKK7,InterPro:IPR006254,InterPro:IPR015813,InterPro:IPR018523,PDB:1F61,PDB:1F8I,PDB:1F8M,NCBI_GP:CCP43200.1;Name=CCP43200.1;Note=Rv0467%2C (MTV038.11)%2C len: 428 aa. Icl1%2C isocitrate lyase (see citations below)%2C highly similar to many%2Cclosest to Z29367|RFISCILY_1 from R. fascians (429 aa)%2CFASTA scores: opt: 2359%2C E(): 0%2C (80.7%25 identity in 429 aa overlap). Belongs to the isocitrate lyase family. Has 2-methyl-isocitrate lyase (MCL) activity in M. tuberculosis Erdman (See Munoz-Elias et al.%2C 2006%3B Gould et al.%2C 2006). Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=icl1;locus_tag=Rv0467;product=Isocitrate lyase Icl (isocitrase) (isocitratase);protein_id=CCP43200.1;transl_table=11
AL123456.3	EMBL	gene	558895	559755	.	+	.	ID=gene-Rv0468;Name=fadB2;gbkey=Gene;gene=fadB2;gene_biotype=protein_coding;locus_tag=Rv0468
AL123456.3	EMBL	CDS	558895	559755	.	+	0	ID=cds-CCP43201.1;Parent=gene-Rv0468;Dbxref=EnsemblGenomes-Gn:Rv0468,EnsemblGenomes-Tr:CCP43201,GOA:P9WNP7,InterPro:IPR006108,InterPro:IPR006176,InterPro:IPR008927,InterPro:IPR013328,InterPro:IPR016040,InterPro:IPR022694,NCBI_GP:CCP43201.1;Name=CCP43201.1;Note=Rv0468%2C (MTV038.12)%2C len: 286 aa. fadB2%2C3-hydroxybutyryl-CoA dehydrogenase%2C equivalent to CAC31978.1|AL583925 3-hydroxyacyl-CoA dehydrogenase from Mycobacterium leprae (287 aa). Also similar to many 3-hydroxybutyryl-CoA dehydrogenases e.g. U32229|BJU32229_1 beta-hydroxybutyryl coenzyme A dehydrogenase from Bradyrhizobium japonicum (293 aa)%2C FASTA scores: opt: 771%2CE(): 0%2C (45.7%25 identity in 282 aa overlap). Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadB2;locus_tag=Rv0468;product=3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD);protein_id=CCP43201.1;transl_table=11
AL123456.3	EMBL	gene	559888	560748	.	+	.	ID=gene-Rv0469;Name=umaA;gbkey=Gene;gene=umaA;gene_biotype=protein_coding;gene_synonym=umaA1;locus_tag=Rv0469
AL123456.3	EMBL	CDS	559888	560748	.	+	0	ID=cds-CCP43202.1;Parent=gene-Rv0469;Dbxref=EnsemblGenomes-Gn:Rv0469,EnsemblGenomes-Tr:CCP43202,GOA:Q6MX39,InterPro:IPR003333,InterPro:IPR029063,UniProtKB/TrEMBL:Q6MX39,NCBI_GP:CCP43202.1;Name=CCP43202.1;Note=Rv0469%2C (MTV038.13)%2C len: 286 aa. Possible umaA%2Cmycolic acid synthase (see citations below)%2C highly similar to CAC30854.1|AL583923 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa)%3B and CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa)%2CFASTA scores: opt: 1402%2C E(): 0%2C (69.6%25 identity in 286 aa overlap). Also very similar to mycobacterial methyltransferases e.g. U77466|CmaD|MBU77466_1 (286 aa)%3B MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa)%3B highly similar to CFA1_MYCTU|Q11195|U66108|MTU66108_1 cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa)%2CFASTA scores: opt: 1360%2C E(): 0%2C (67.8%25 identity in 286 aa overlap) (see citation below)%3B and very similar also to methoxy mycolic acid synthase 1 from Mycobacterium tuberculosis e.g. MTU66108_1 (286 aa). Note that previously known as umaA1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=umaA;locus_tag=Rv0469;product=Possible mycolic acid synthase UmaA;protein_id=CCP43202.1;transl_table=11
AL123456.3	EMBL	gene	560848	561711	.	-	.	ID=gene-Rv0470c;Name=pcaA;gbkey=Gene;gene=pcaA;gene_biotype=protein_coding;gene_synonym=umaA2;locus_tag=Rv0470c
AL123456.3	EMBL	CDS	560848	561711	.	-	0	ID=cds-CCP43203.1;Parent=gene-Rv0470c;Dbxref=EnsemblGenomes-Gn:Rv0470c,EnsemblGenomes-Tr:CCP43203,GOA:P9WPB3,InterPro:IPR003333,InterPro:IPR029063,PDB:1L1E,NCBI_GP:CCP43203.1;Name=CCP43203.1;Note=Rv0470c%2C (MTV038.14)%2C len: 287 aa. PcaA (previously known as umaA2)%2C mycolic acid synthase (cyclopropane synthase) (see citations below)%2C equivalent to CAC31976.1|AL583925 Mycolic acid synthase from Mycobacterium leprae (295 aa)%3B and highly similar to S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical protein from Mycobacterium leprae (308 aa)%3B Q11195|CFA1_MYCTU cyclopropane-fatty-acyl-phospholipid synthase 1 (cyclopropane mycolic acid synthase 1) (287 aa) (see Glickman et al.%2C 2000)%3B U27357|MTU27357_1 cyclopropane mycolic acid synthase from Mycobacterium tuberculosis (287 aa)%2C FASTA scores: opt: 1415%2C E(): 0%2C (72.8%25 identity in 287 aa overlap)%3B and related enzymes e.g. MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa)%2C FASTA scores: opt: 1387%2C E(): 0%2C (72.5%25 identity in 287 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pcaA;locus_tag=Rv0470c;product=Mycolic acid synthase PcaA (cyclopropane synthase);protein_id=CCP43203.1;transl_table=11
AL123456.3	EMBL	gene	561854	562294	.	-	.	ID=gene-Rv0470A;Name=Rv0470A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0470A
AL123456.3	EMBL	CDS	561854	562294	.	-	0	ID=cds-CCP43204.1;Parent=gene-Rv0470A;Dbxref=EnsemblGenomes-Gn:Rv0470A,EnsemblGenomes-Tr:CCP43204,GOA:L7N651,InterPro:IPR000537,UniProtKB/TrEMBL:L7N651,NCBI_GP:CCP43204.1;Name=CCP43204.1;Note=Rv0470A%2C len: 146 aa. Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein%2C could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in Mycobacterium bovis and Mycobacterium tuberculosis strain CDC1551. Weak hits to Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for NOTCH4 from Homo sapiens (1095 aa)%2C FASTA scores: opt: 132%2CE(): 1.1%2C (39.35%25 identity in 61 aa overlap).;gbkey=CDS;locus_tag=Rv0470A;product=Hypothetical protein;protein_id=CCP43204.1;transl_table=11
AL123456.3	EMBL	gene	562225	562713	.	-	.	ID=gene-Rv0471c;Name=Rv0471c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0471c
AL123456.3	EMBL	CDS	562225	562713	.	-	0	ID=cds-CCP43205.1;Parent=gene-Rv0471c;Dbxref=EnsemblGenomes-Gn:Rv0471c,EnsemblGenomes-Tr:CCP43205,UniProtKB/TrEMBL:O53756,NCBI_GP:CCP43205.1;Name=CCP43205.1;Note=Rv0471c%2C (MTV038.15c)%2C len: 162 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0471c;product=Hypothetical protein;protein_id=CCP43205.1;transl_table=11
AL123456.3	EMBL	gene	562723	563427	.	-	.	ID=gene-Rv0472c;Name=Rv0472c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0472c
AL123456.3	EMBL	CDS	562723	563427	.	-	0	ID=cds-CCP43206.1;Parent=gene-Rv0472c;Dbxref=EnsemblGenomes-Gn:Rv0472c,EnsemblGenomes-Tr:CCP43206,GOA:P9WMD9,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,NCBI_GP:CCP43206.1;Name=CCP43206.1;Note=Rv0472c%2C (MTV038.16c)%2C len: 234 aa. Probable regulatory protein%2C possibly TetR family%2C equivalent to CAC31974.1|AL583925 possible TetR-family transcriptional regulator from Mycobacterium leprae (233 aa). Also similar to CAC01492.1|AL391017 putative transcriptional regulatory protein from Streptomyces coelicolor (218 aa)%3B and CAC01371.1|AL390975 putative TetR-family transcriptional regulator from Streptomyces coelicolor (228 aa). Also similar to AL0212|MTV012_65 from Mycobacterium tuberculosis (246 aa)%2C FASTA scores: opt: 327%2C E(): 1.8e-15%2C (31.0%25 identity in 232 aa overlap)%3B and Z95120|MTCY07D11.18c (228 aa)%2C FASTA scores: opt: 190%2C E(): 4.4e-06%2C (23.1%25 identity in 186 aa overlap). Contains probable helix-turn-helix doimain at aa 45-66 (Score 1429%2C +4.05 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0472c;product=Probable transcriptional regulatory protein (possibly TetR-family);protein_id=CCP43206.1;transl_table=11
AL123456.3	EMBL	gene	563564	564934	.	+	.	ID=gene-Rv0473;Name=Rv0473;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0473
AL123456.3	EMBL	CDS	563564	564934	.	+	0	ID=cds-CCP43207.1;Parent=gene-Rv0473;Dbxref=EnsemblGenomes-Gn:Rv0473,EnsemblGenomes-Tr:CCP43207,GOA:I6Y3V3,InterPro:IPR007383,UniProtKB/TrEMBL:I6Y3V3,NCBI_GP:CCP43207.1;Name=CCP43207.1;Note=Rv0473%2C (MTV038.17)%2C len: 456 aa. Possible conserved transmembrane protein%2C showing some similarity to hypothetical proteins e.g. NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical protein from Mesorhizobium loti (431 aa)%3B P39385|YJIN_ECOLI|YJIN|B4336 hypothetical 48.2 kDa protein (potential integral membrane protein) from Escherichia coli strain K12 (426 aa)%2C FASTA scores: opt: 396%2C E(): 9.8e-19%2C(31.8 %25 identity in 424 aa overlap)%3B etc. Nucleotide position 563577 in the genome sequence has been corrected%2CA:G resulting in K5R.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0473;product=Possible conserved transmembrane protein;protein_id=CCP43207.1;transl_table=11
AL123456.3	EMBL	gene	565021	565443	.	+	.	ID=gene-Rv0474;Name=Rv0474;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0474
AL123456.3	EMBL	CDS	565021	565443	.	+	0	ID=cds-CCP43208.1;Parent=gene-Rv0474;Dbxref=EnsemblGenomes-Gn:Rv0474,EnsemblGenomes-Tr:CCP43208,GOA:P9WMH9,InterPro:IPR001387,InterPro:IPR010982,NCBI_GP:CCP43208.1;Name=CCP43208.1;Note=Rv0474%2C (MTV038.18)%2C len: 140 aa. Probable transcriptional regulator%2C highly similar to others e.g. CAC04034.1|AL391406 putative DNA-binding protein from Streptomyces coelicolor (141 aa)%3B N-terminus of NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional regulator from Mesorhizobium loti (219 aa)%3B N-terminus of A83618|PA0225 probable transcription regulator from Pseudomonas aeruginosa (179 aa)%3B SINR_BACSU|P06533 sinr protein from Bacillus subtilis (111 aa)%2C FASTA scores: opt: 147%2C E(): 8.9e-06%2C (30.6%25 identity in 111 aa overlap). Also similar to other hypothetical proteins e.g. X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa)%2C FASTA scores: opt: 280%2C E(): 4.8e-12%2C (43.6%25 identity in 117 aa overlap). Also similar to Rv2745c from Mycobacterium tuberculosis. Contains probable helix-turn-helix domain at aa 35-56 (Score 1709%2C +5.01 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0474;product=Probable transcriptional regulatory protein;protein_id=CCP43208.1;transl_table=11
AL123456.3	EMBL	gene	565797	566396	.	+	.	ID=gene-Rv0475;Name=hbhA;gbkey=Gene;gene=hbhA;gene_biotype=protein_coding;locus_tag=Rv0475
AL123456.3	EMBL	CDS	565797	566396	.	+	0	ID=cds-CCP43209.1;Parent=gene-Rv0475;Dbxref=EnsemblGenomes-Gn:Rv0475,EnsemblGenomes-Tr:CCP43209,GOA:P9WIP9,InterPro:IPR020340,NCBI_GP:CCP43209.1;Name=CCP43209.1;Note=Rv0475%2C hbhA (MTCY20G9.01)%2C len: 199 aa. HbhA%2Ciron-regulated heparin-binding hemagglutinin (see citations below)%2C equivalent to CAC31971.1|AL583925 possible hemagglutinin from Mycobacterium leprae (188 aa). Contains possible N-terminal signal sequence and K-a-rich region at C-terminus: subcellular location: surface associated. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hbhA;locus_tag=Rv0475;product=Iron-regulated heparin binding hemagglutinin HbhA (adhesin);protein_id=CCP43209.1;transl_table=11
AL123456.3	EMBL	gene	566508	566771	.	+	.	ID=gene-Rv0476;Name=Rv0476;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0476
AL123456.3	EMBL	CDS	566508	566771	.	+	0	ID=cds-CCP43210.1;Parent=gene-Rv0476;Dbxref=EnsemblGenomes-Gn:Rv0476,EnsemblGenomes-Tr:CCP43210,GOA:P9WKW1,InterPro:IPR019662,NCBI_GP:CCP43210.1;Name=CCP43210.1;Note=Rv0476%2C (MTCY20G9.02)%2C len: 87 aa. Possible conserved transmembrane protein%2C equivalent to CAC31970.1|AL583925 conserved membrane protein from Mycobacterium leprae (95 aa). Also highly similar to CAC04036.1|AL391406 putative membrane protein from Streptomyces coelicolor (113 aa). Contains PS00606 Beta-ketoacyl synthases active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00606;locus_tag=Rv0476;product=Possible conserved transmembrane protein;protein_id=CCP43210.1;transl_table=11
AL123456.3	EMBL	gene	566776	567222	.	+	.	ID=gene-Rv0477;Name=Rv0477;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0477
AL123456.3	EMBL	CDS	566776	567222	.	+	0	ID=cds-CCP43211.1;Parent=gene-Rv0477;Dbxref=EnsemblGenomes-Gn:Rv0477,EnsemblGenomes-Tr:CCP43211,GOA:P9WKV9,InterPro:IPR019719,NCBI_GP:CCP43211.1;Name=CCP43211.1;Note=Rv0477%2C (MTCY20G9.03)%2C len: 148 aa. Possible conserved secreted protein%2C equivalent to CAC31969.1|AL583925 hypothetical protein from Mycobacterium leprae (123 aa). Also similar to G83406|PA1914 conserved hypothetical protein from Pseudomonas aeruginosa (408 aa). Contains possible N-terminal signal sequence. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0477;product=Possible conserved secreted protein;protein_id=CCP43211.1;transl_table=11
AL123456.3	EMBL	gene	567222	567896	.	+	.	ID=gene-Rv0478;Name=deoC;gbkey=Gene;gene=deoC;gene_biotype=protein_coding;locus_tag=Rv0478
AL123456.3	EMBL	CDS	567222	567896	.	+	0	ID=cds-CCP43212.1;Parent=gene-Rv0478;Dbxref=EnsemblGenomes-Gn:Rv0478,EnsemblGenomes-Tr:CCP43212,GOA:P9WP03,InterPro:IPR002915,InterPro:IPR011343,InterPro:IPR013785,InterPro:IPR028581,NCBI_GP:CCP43212.1;Name=CCP43212.1;Note=Rv0478%2C (MTCY20G9.04)%2C len: 224 aa. Probable deoC%2Cdeoxyribose-phosphate aldolase%2C equivalent to Q9CB45|DEOC_MYCLE deoxyribose-phosphate aldolase from Mycobacterium leprae (226 aa). Also highly similar to others e.g. DEOC_BACSU|P39121 from Bacillus subtilis (214 aa)%2C FASTA scores: opt: 543%2C E(): 1.4e-26%2C (45.9%25 identity in 209 aa overlap)%3B etc. Belongs to the DEOC/FBAB family of aldolases%2C DEOC subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=deoC;locus_tag=Rv0478;product=Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase);protein_id=CCP43212.1;transl_table=11
AL123456.3	EMBL	gene	567921	568967	.	-	.	ID=gene-Rv0479c;Name=Rv0479c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0479c
AL123456.3	EMBL	CDS	567921	568967	.	-	0	ID=cds-CCP43213.1;Parent=gene-Rv0479c;Dbxref=EnsemblGenomes-Gn:Rv0479c,EnsemblGenomes-Tr:CCP43213,GOA:P9WKV7,InterPro:IPR021373,NCBI_GP:CCP43213.1;Name=CCP43213.1;Note=Rv0479c%2C (MTCY20G9.04c)%2C len: 348 aa. Probable conserved membrane protein%2C equivalent to CAC31967.1|AL583925 possible secreted protein from Mycobacterium leprae (254 aa)%3B and C-terminus highly similar to AAF74996.1|AF143402_1|AF143402 putative multicopper oxidase from Mycobacterium avium (149 aa). Contains hydrophobic domain in centre of protein. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0479c;product=Probable conserved membrane protein;protein_id=CCP43213.1;transl_table=11
AL123456.3	EMBL	gene	568964	569806	.	-	.	ID=gene-Rv0480c;Name=Rv0480c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0480c
AL123456.3	EMBL	CDS	568964	569806	.	-	0	ID=cds-CCP43214.1;Parent=gene-Rv0480c;Dbxref=EnsemblGenomes-Gn:Rv0480c,EnsemblGenomes-Tr:CCP43214,GOA:P9WJ01,InterPro:IPR001110,InterPro:IPR003010,NCBI_GP:CCP43214.1;Name=CCP43214.1;Note=Rv0480c%2C (MTCY20G9.06c)%2C len: 280 aa. Possible amidohydrolase%2C highly similar to NP_302587.1|NC_002677|CAC31966.1|AL583925 putative hydrolase from Mycobacterium leprae (271 aa). Also similar to other hydrolases and hypothetical proteins e.g. NP_601985.1|NC_003450 Predicted amidohydrolase from Corynebacterium glutamicum (266 aa)%3B NP_459623.1|NC_003197 putative hydrolase from Salmonella typhimurium LT2 (262 aa)%3B AL096822|SCGD3_8|NP_627996.1|NC_003888 probable hydrolase from Streptomyces coelicolor (264 aa)%2C FASTA scores: opt: 368%2C E(): 6.1e-15%2C (34.2%25 identity in 272 aa overlap)%3B YAUB_SCHPO|Q10166 hypothetical 35.7 kDa protein c26a3.11 from S. pombe (322 aa)%2C FASTA scores: opt: 338%2CE():1.4e-13%2C (30.3%25 identity in 277 aa overlap)%3B etc. Start changed since first submission (-60 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0480c;product=Possible amidohydrolase;protein_id=CCP43214.1;transl_table=11
AL123456.3	EMBL	gene	569988	570512	.	-	.	ID=gene-Rv0481c;Name=Rv0481c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0481c
AL123456.3	EMBL	CDS	569988	570512	.	-	0	ID=cds-CCP43215.1;Parent=gene-Rv0481c;Dbxref=EnsemblGenomes-Gn:Rv0481c,EnsemblGenomes-Tr:CCP43215,GOA:P9WKV5,InterPro:IPR019639,NCBI_GP:CCP43215.1;Name=CCP43215.1;Note=Rv0481c%2C (MTCY20G9.07c)%2C len: 174 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0481c;product=Hypothetical protein;protein_id=CCP43215.1;transl_table=11
AL123456.3	EMBL	gene	570539	571648	.	+	.	ID=gene-Rv0482;Name=murB;gbkey=Gene;gene=murB;gene_biotype=protein_coding;locus_tag=Rv0482
AL123456.3	EMBL	CDS	570539	571648	.	+	0	ID=cds-CCP43216.1;Parent=gene-Rv0482;Dbxref=EnsemblGenomes-Gn:Rv0482,EnsemblGenomes-Tr:CCP43216,GOA:P9WJL9,InterPro:IPR003170,InterPro:IPR006094,InterPro:IPR011601,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,NCBI_GP:CCP43216.1;Name=CCP43216.1;Note=Rv0482%2C (MTCY20G9.08)%2C len: 369 aa. Probable murB%2CUDP-N-acetylenolpyruvoylglucosamine reductase (see citation below)%2C equivalent to CAC31964.1|AL583925 UDP-N-acetylenolpyruvoylglucosamine reductase from Mycobacterium leprae (367 aa). Also highly similar to others e.g. MURB_ECOLI|P08373 UDP-N-acetylenolpyruvoylglucosamine reductase from Escherichia coli (342 aa)%2C FASTA scores: opt: 292%2C E(): 6.3e-12%2C (33.5%25 identity in 355 aa overlap)%3B etc. Belongs to the MurB family. Cofactor: FAD.;gbkey=CDS;gene=murB;locus_tag=Rv0482;product=Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase);protein_id=CCP43216.1;transl_table=11
AL123456.3	EMBL	gene	571710	573065	.	+	.	ID=gene-Rv0483;Name=lprQ;gbkey=Gene;gene=lprQ;gene_biotype=protein_coding;locus_tag=Rv0483
AL123456.3	EMBL	CDS	571710	573065	.	+	0	ID=cds-CCP43217.1;Parent=gene-Rv0483;Dbxref=EnsemblGenomes-Gn:Rv0483,EnsemblGenomes-Tr:CCP43217,GOA:P9WKV3,InterPro:IPR005490,NCBI_GP:CCP43217.1;Name=CCP43217.1;Note=Rv0483%2C (MTCY20G9.09)%2C len: 451 aa. Probable lprQ%2Cconserved lipoprotein%2C equivalent to CAC31963.1|AL583925|ML2446 possible lipoprotein from Mycobacterium leprae (441 aa)%3B appears longer than ML2446%2Cso start may be further downstream. Shows also similarity with MLCL383_24|O07707 hypothetical 43.6 kDa protein from Mycobacterium leprae%3B and to Q49706|B1496_F2_81 (271 aa). Similar to others lipoproteins from other organisms. Also similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0116c%2C Rv0192%2C Rv1433%2C Rv2518c. Contains potential N-terminal signal sequence and appropriately positioned PS00013 prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprQ;locus_tag=Rv0483;product=Probable conserved lipoprotein LprQ;protein_id=CCP43217.1;transl_table=11
AL123456.3	EMBL	gene	573046	573801	.	-	.	ID=gene-Rv0484c;Name=Rv0484c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0484c
AL123456.3	EMBL	CDS	573046	573801	.	-	0	ID=cds-CCP43218.1;Parent=gene-Rv0484c;Dbxref=EnsemblGenomes-Gn:Rv0484c,EnsemblGenomes-Tr:CCP43218,GOA:P9WGR5,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,NCBI_GP:CCP43218.1;Name=CCP43218.1;Note=Rv0484c%2C (MTCY20G9.10c)%2C len: 251 aa. Probable short-chain oxidoreductase%2C highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (260 aa)%3B YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR family) from Haemophilus influenzae (252 aa)%2C FASTA scores: opt: 496%2C E(): 7.9e-25%2C (35.0 %25 identity in 243 aa overlap)%3B etc. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Strong similarity%2Cto bacterial YDFG homologs.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0484c;product=Probable short-chain type oxidoreductase;protein_id=CCP43218.1;transl_table=11
AL123456.3	EMBL	gene	573984	575300	.	+	.	ID=gene-Rv0485;Name=Rv0485;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0485
AL123456.3	EMBL	CDS	573984	575300	.	+	0	ID=cds-CCP43219.1;Parent=gene-Rv0485;Dbxref=EnsemblGenomes-Gn:Rv0485,EnsemblGenomes-Tr:CCP43219,GOA:P9WKV1,InterPro:IPR000600,InterPro:IPR011991,NCBI_GP:CCP43219.1;Name=CCP43219.1;Note=Rv0485%2C (MTCY20G9.11)%2C len: 438 aa. Possible transcriptional repressor%2C member of the NAGC/XYLR repressor family%3B similar to several e.g. D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor from Vibrio cholerae (404 aa)%2C FASTA scores: opt: 378%2C E(): 1.2e-17%2C (26.9%25 identity in 350 aa overlap)%3B NAGC_ECOLI|P15301 N-acetylglucosamine repressor from Escherichia coli (406 aa)%2C FASTA scores: opt: 305%2C E(): 1.8e-12%2C (21.8%25 identity in 357 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0485;product=Possible transcriptional regulatory protein;protein_id=CCP43219.1;transl_table=11
AL123456.3	EMBL	gene	575033	575069	.	+	.	ID=gene-mcr19;Name=mcr19;gbkey=Gene;gene=mcr19;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	575033	575069	.	+	.	ID=rna-mcr19;Parent=gene-mcr19;Note=mcr19%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C cloned from M. bovis BCG Pasteur%3B ends not mapped%2C 66-82 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mcr19;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	575033	575069	.	+	.	ID=exon-mcr19-1;Parent=rna-mcr19;Note=mcr19%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C cloned from M. bovis BCG Pasteur%3B ends not mapped%2C 66-82 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mcr19;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	575348	576790	.	+	.	ID=gene-Rv0486;Name=mshA;gbkey=Gene;gene=mshA;gene_biotype=protein_coding;locus_tag=Rv0486
AL123456.3	EMBL	CDS	575348	576790	.	+	0	ID=cds-CCP43220.1;Parent=gene-Rv0486;Dbxref=EnsemblGenomes-Gn:Rv0486,EnsemblGenomes-Tr:CCP43220,GOA:P9WMY7,InterPro:IPR001296,InterPro:IPR017814,InterPro:IPR028098,NCBI_GP:CCP43220.1;Name=CCP43220.1;Note=Rv0486%2C (MTCY20G9.12)%2C len: 480 aa. MshA%2Cglycosyltransferase (see citations below)%2C highly similar to P54138|Y486_MYCLE|ML2443 possible glycosyl transferase from Mycobacterium leprae (428 aa)%3B and S72892|B2168_C2_201 probable hexosyltransferase from Mycobacterium leprae (409 aa)%2C FASTA scores: opt: 2375%2C E(): 0%2C (86.4%25 identity in 413 aa overlap). Also highly similar to CAC04040.1|AL391406 putative transferase from Streptomyces coelicolor (496 aa)%3B and similar to various transferases e.g. NP_437172.1|NC_003078 putative membrane-anchored glycosyltransferase protein from Sinorhizobium meliloti (416 aa)%3B O26550|U67601_1 LPS biosynthesis related protein from Methanococcus jannaschii (411 aa)%2C FASTA score: (25.3%25 identity in 387 aa overlap)%3B etc. Also similar to CAC87824.1|AJ316594 putative sucrose-phosphate synthase from Nostoc punctiforme (422 aa). Contains a match to Pfam entry PF00534 glycosyl_transf_1 - Glycosyl transferases group 1.;gbkey=CDS;gene=mshA;inference=protein motif:PROSITE:PS00039;locus_tag=Rv0486;product=Glycosyltransferase MshA;protein_id=CCP43220.1;transl_table=11
AL123456.3	EMBL	gene	576787	577338	.	+	.	ID=gene-Rv0487;Name=Rv0487;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0487
AL123456.3	EMBL	CDS	576787	577338	.	+	0	ID=cds-CCP43221.1;Parent=gene-Rv0487;Dbxref=EnsemblGenomes-Gn:Rv0487,EnsemblGenomes-Tr:CCP43221,InterPro:IPR019660,NCBI_GP:CCP43221.1;Name=CCP43221.1;Note=Rv0487%2C (MTCY20G9.13)%2C len: 183 aa. Conserved hypothetical protein%2C highly similar to P54139|Y487_MYCLE|U00018_38|ML2442 hypothetical 20.8 KDA protein from Mycobacterium leprae (184 aa)%2C FASTA scores: opt: 760%2C E(): 2.4 e-34%2C (73.0%25 identity in 159 aa overlap). Also highly similar to CAC04041.1|AL391406 conserved hypothetical protein from Streptomyces coelicolor (168 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0487;product=Conserved hypothetical protein;protein_id=CCP43221.1;transl_table=11
AL123456.3	EMBL	gene	577664	578269	.	+	.	ID=gene-Rv0488;Name=Rv0488;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0488
AL123456.3	EMBL	CDS	577664	578269	.	+	0	ID=cds-CCP43222.1;Parent=gene-Rv0488;Dbxref=EnsemblGenomes-Gn:Rv0488,EnsemblGenomes-Tr:CCP43222,GOA:P9WK33,InterPro:IPR001123,InterPro:IPR004777,NCBI_GP:CCP43222.1;Name=CCP43222.1;Note=Rv0488%2C (MTCY20G9.14)%2C len: 201 aa. Probable conserved integral membrane protein%2C LysE family possibly involved in transport of Lysine%2C similar to others and conserved hypothetical proteins e.g. AB93746.1|AL357613 putative membrane transport protein from Streptomyces coelicolor (204 aa)%3B D83100|PA4365 probable transporter from Pseudomonas aeruginosa (200 aa)%3B YGGA_ECOLI|P11667 hypothetical 21.7 kDa protein from Escherichia coli (197 aa)%2C FASTA scores: opt: 382%2C E(): 1.1e-19%2C (39.1%25 identity in 179 aa overlap)%3B CGLYSEG_2 C|P94633 lysine exporter protein (236 aa)%2C FASTA scores: E(): 2.3e-07%2C (33.3%25 identity in 219 aa overlap). Also similar to Rv1986 from Mycobacterium tuberculosis.;gbkey=CDS;locus_tag=Rv0488;product=Probable conserved integral membrane protein;protein_id=CCP43222.1;transl_table=11
AL123456.3	EMBL	gene	578426	579175	.	+	.	ID=gene-Rv0489;Name=gpm1;gbkey=Gene;gene=gpm1;gene_biotype=protein_coding;gene_synonym=gpm;locus_tag=Rv0489
AL123456.3	EMBL	CDS	578426	579175	.	+	0	ID=cds-CCP43223.1;Parent=gene-Rv0489;Dbxref=EnsemblGenomes-Gn:Rv0489,EnsemblGenomes-Tr:CCP43223,GOA:P9WIC9,InterPro:IPR001345,InterPro:IPR005952,InterPro:IPR013078,InterPro:IPR029033,PDB:1RII,NCBI_GP:CCP43223.1;Name=CCP43223.1;Note=Rv0489%2C (MTCY20G9.15)%2C len: 249 aa. Probable gpm1%2Cphosphoglycerate mutase 1%2C equivalent to P53531|PMGY_MYCLE phosphoglycerate mutase from Mycobacterium leprae (247 aa). Also highly similar to others e.g. PMG1_ECOLI|P31217 (249 aa)%2C FASTA scores: opt: 805%2C E(): 0%2C (51.4%25 identity in 245 aa overlap)%3B etc. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature%2C and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the phosphoglycerate mutase family. Note that previously known as gpm.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gpm1;inference=protein motif:PROSITE:PS00175;locus_tag=Rv0489;product=Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM);protein_id=CCP43223.1;transl_table=11
AL123456.3	EMBL	gene	579349	580581	.	+	.	ID=gene-Rv0490;Name=senX3;gbkey=Gene;gene=senX3;gene_biotype=protein_coding;locus_tag=Rv0490
AL123456.3	EMBL	CDS	579349	580581	.	+	0	ID=cds-CCP43224.1;Parent=gene-Rv0490;Dbxref=EnsemblGenomes-Gn:Rv0490,EnsemblGenomes-Tr:CCP43224,GOA:P9WGK5,InterPro:IPR003594,InterPro:IPR003661,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR009082,NCBI_GP:CCP43224.1;Name=CCP43224.1;Note=Rv0490%2C (MTCY20G9.16)%2C len: 410 aa. Putative senX3%2Ctwo-component sensor histidine kinase%2C transmembrane protein (see citations below)%2C equivalent to O07129|SEX3_MYCBO sensor-like histidine kinase SENX3 from Mycobacterium bovis BCG (410 aa)%2C FASTA scores: E(): 0%2C(99.5%25 identity in 410 aa overlap)%3B and highly similar to P54883|SEX3_MYCLE|SENX3 sensor-like histidine kinase from Mycobacterium leprae (443 aa)%2C FASTA score: (83.8%25 identity in 408 aa overlap). Also highly similar%2C except in N-terminus%2C to CAC31957.1|AL583925 probable two-component system sensor histidine kinase from Mycobacterium leprae (441 aa). Also highly similar to sensor kinase proteins from other organisms e.g. CAB77323.1|AL160331 putative sensor kinase protein from Streptomyces coelicolor (426 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=senX3;locus_tag=Rv0490;product=Putative two component sensor histidine kinase SenX3;protein_id=CCP43224.1;transl_table=11
AL123456.3	EMBL	repeat_region	580578	580654	.	+	.	ID=id-AL123456.3:580578..580654;Note=77 bp Mycobacterial Interspersed Repetitive Unit%2CClass I (see Supply et al.%2C 1997);gbkey=repeat_region
AL123456.3	EMBL	repeat_region	580655	580731	.	+	.	ID=id-AL123456.3:580655..580731;Note=77 bp Mycobacterial Interspersed Repetitive Unit%2CClass I (see Supply et al.%2C 1997);gbkey=repeat_region
AL123456.3	EMBL	repeat_region	580732	580808	.	+	.	ID=id-AL123456.3:580732..580808;Note=77 bp Mycobacterial Interspersed Repetitive Unit%2CClass I (see Supply et al.%2C 1997);gbkey=repeat_region
AL123456.3	EMBL	gene	580809	581492	.	+	.	ID=gene-Rv0491;Name=regX3;gbkey=Gene;gene=regX3;gene_biotype=protein_coding;locus_tag=Rv0491
AL123456.3	EMBL	CDS	580809	581492	.	+	0	ID=cds-CCP43225.1;Parent=gene-Rv0491;Dbxref=EnsemblGenomes-Gn:Rv0491,EnsemblGenomes-Tr:CCP43225,GOA:P9WGL9,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,InterPro:IPR016032,PDB:2OQR,NCBI_GP:CCP43225.1;Name=CCP43225.1;Note=Rv0491%2C (MTCY20G9.17)%2C len: 227 aa. RegX3%2C response regulator protein (sensory transduction protein) (see citations below)%2C equivalent to O07130|RGX3_MYCBO|REGX3 sensory transduction protein from Mycobacterium bovis BCG (227 aa)%3B AAG09797.1|AF258346_2|AF258346|REGX3 response regulator from Mycobacterium smegmatis (228 aa)%3B equivalent to P54884|RGX3_MYCLE|REGX3 sensory transduction protein from Mycobacterium leprae (198 aa)%2C FASTA scores : E(): 0%2C(95.4%25 identity in 197 aa overlap). Also highly similar to other response regulators e.g. AAG43239.1|AF123314_2 |AF123314 putative response regulator from Corynebacterium glutamicum (232 aa).;gbkey=CDS;gene=regX3;locus_tag=Rv0491;product=Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family);protein_id=CCP43225.1;transl_table=11
AL123456.3	EMBL	gene	581489	583378	.	-	.	ID=gene-Rv0492c;Name=Rv0492c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0492c
AL123456.3	EMBL	CDS	581489	583378	.	-	0	ID=cds-CCP43226.1;Parent=gene-Rv0492c;Dbxref=EnsemblGenomes-Gn:Rv0492c,EnsemblGenomes-Tr:CCP43226,GOA:P9WMV7,InterPro:IPR000172,InterPro:IPR007867,NCBI_GP:CCP43226.1;Name=CCP43226.1;Note=Rv0492c%2C (MT0511/MT0512%2C MTCY20G9.18c)%2C len: 629 aa. Probable oxidoreductase GMC type%2C similar to others except in N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN hypothetical GMC-type oxidoreductase from Rhizobium sp. (505 aa)%2C FASTA scores: opt: 873%2C E():0%2C (34.3%25 identity in 502 aa overlap)%3B YTH2_RHOER|P46371 hypothetical 53.0 kDa GMC-type oxidoreductase from Rhodococcus erythropolis (493 aa)%2C FASTA score: (25.7%25 identity in 521 aa overlap)%3B YTH2_RHOSO|P46371 hypothetical 53.0 kDa gmc-type oxidoreductase from Rhodococcus erythropolis (493 aa)%2CFASTA score: (25.7%25 identity in 521 aa overlap)%3B NP_085596.1|NC_002679 probable oxidoreductase from Mesorhizobium loti (507 aa)%3B NP_285451.1|NC_001264 GMC oxidoreductase from Deinococcus radiodurans (722 aa)%3B NP_249055.1|NC_002516 probable oxidoreductase from Pseudomonas aeruginosa (531 aa)%3B etc. Contains PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature%2Cand PS00624 GMC oxidoreductases signature 2. Belongs to the GMC oxidoreductases family. Cofactor: FAD (by similarity). Note that start changed since first submission (previously 684 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00624;locus_tag=Rv0492c;product=Probable oxidoreductase GMC-type;protein_id=CCP43226.1;transl_table=11
AL123456.3	EMBL	gene	583375	583704	.	-	.	ID=gene-Rv0492A;Name=Rv0492A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0492A
AL123456.3	EMBL	CDS	583375	583704	.	-	0	ID=cds-CCP43227.1;Parent=gene-Rv0492A;Dbxref=EnsemblGenomes-Gn:Rv0492A,EnsemblGenomes-Tr:CCP43227,UniProtKB/TrEMBL:Q6MX36,NCBI_GP:CCP43227.1;Name=CCP43227.1;Note=Rv0492A%2C len: 109 aa. Hypothetical unknown protein. GC plot suggests CDS.;gbkey=CDS;locus_tag=Rv0492A;product=Hypothetical protein;protein_id=CCP43227.1;transl_table=11
AL123456.3	EMBL	gene	583701	584690	.	-	.	ID=gene-Rv0493c;Name=Rv0493c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0493c
AL123456.3	EMBL	CDS	583701	584690	.	-	0	ID=cds-CCP43228.1;Parent=gene-Rv0493c;Dbxref=EnsemblGenomes-Gn:Rv0493c,EnsemblGenomes-Tr:CCP43228,NCBI_GP:CCP43228.1;Name=CCP43228.1;Note=Rv0493c%2C (MTCY20G9.19)%2C len: 329 aa. Conserved protein%2C showing some similarity to U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa)%2C FASTA scores: opt: 166%2CE(): 0.00077%2C (35.9%25 identity in 131 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0493c;product=Conserved protein;protein_id=CCP43228.1;transl_table=11
AL123456.3	EMBL	gene	584695	585423	.	+	.	ID=gene-Rv0494;Name=Rv0494;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0494
AL123456.3	EMBL	CDS	584695	585423	.	+	0	ID=cds-CCP43229.1;Parent=gene-Rv0494;Dbxref=EnsemblGenomes-Gn:Rv0494,EnsemblGenomes-Tr:CCP43229,GOA:P9WMG7,InterPro:IPR000524,InterPro:IPR008920,InterPro:IPR011711,InterPro:IPR011991,NCBI_GP:CCP43229.1;Name=CCP43229.1;Note=Rv0494%2C (MTCY20G9.20)%2C len: 242 aa. Probable transcriptional regulator%2C GntR family%2C with C-terminal part highly similar to S72893|B2168_C2_205 hypothetical protein from Mycobacterium leprae (105 aa). Also similar to other transcription regulators e.g. PDHR_ECOLI|P06957 pyruvate dehydrogenase complex repressor PDHR or GENA from Escherichia coli (254 aa)%2C FASTA scores: opt: 284%2C E(): 1.2e-11%2C (32.6%25 identity in 224 aa overlap)%3B etc. Contains PS00043 Bacterial regulatory proteins%2C gntR family signature%2C and probable helix-turn helix motif from aa 50-71 (Score 1229%2C +3.37 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00043;locus_tag=Rv0494;product=Probable transcriptional regulatory protein (probably GntR-family);protein_id=CCP43229.1;transl_table=11
AL123456.3	EMBL	gene	585424	586314	.	-	.	ID=gene-Rv0495c;Name=Rv0495c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0495c
AL123456.3	EMBL	CDS	585424	586314	.	-	0	ID=cds-CCP43230.1;Parent=gene-Rv0495c;Dbxref=EnsemblGenomes-Gn:Rv0495c,EnsemblGenomes-Tr:CCP43230,NCBI_GP:CCP43230.1;Name=CCP43230.1;Note=Rv0495c%2C (MTCY20G9.21c)%2C len: 296 aa. Conserved hypothetical protein%2C highly similar to S72915|B2168_F1_37 hypothetical protein from Mycobacterium leprae (323 aa)%2CFASTA scores: opt: 1615%2C E(): 0%2C (82.7%25 identity in 271 aa overlap)%3B and P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16 hypothetical protein from Streptomyces coelicolor (271 aa).;gbkey=CDS;locus_tag=Rv0495c;product=Conserved hypothetical protein;protein_id=CCP43230.1;transl_table=11
AL123456.3	EMBL	gene	586394	587380	.	+	.	ID=gene-Rv0496;Name=Rv0496;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0496
AL123456.3	EMBL	CDS	586394	587380	.	+	0	ID=cds-CCP43231.1;Parent=gene-Rv0496;Dbxref=EnsemblGenomes-Gn:Rv0496,EnsemblGenomes-Tr:CCP43231,GOA:P9WHV5,InterPro:IPR003695,NCBI_GP:CCP43231.1;Name=CCP43231.1;Note=Rv0496%2C (MTCY20G9.22)%2C len: 328 aa. Conserved hypothetical protein%2C highly similar to S72894|467046|AAA17230.1|U00018 exopolyphosphatase ppx from Mycobacterium leprae (406 aa)%2C FASTA scores: opt: 1902%2CE(): 0%2C (86.6%25 identity in 343 aa overlap)%3B and P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925 hypothetical 36.2 KDA protein from Mycobacterium leprae (339 aa). Also highly similar to hypothetical proteins and exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c hypothetical protein from Streptomyces coelicolor (309 aa). C-terminal region similar to CGU31224_1|Q46054 protein similar to ppx gene product of Mycobacterium leprae from Cornybacterium glutamicum (140 aa)%2C FASTA scores: opt: 615%2CE(): 2.7e-33%2C (70.9%25 identity in 134 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0496;product=Conserved hypothetical protein;protein_id=CCP43231.1;transl_table=11
AL123456.3	EMBL	gene	587377	588309	.	+	.	ID=gene-Rv0497;Name=Rv0497;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0497
AL123456.3	EMBL	CDS	587377	588309	.	+	0	ID=cds-CCP43232.1;Parent=gene-Rv0497;Dbxref=EnsemblGenomes-Gn:Rv0497,EnsemblGenomes-Tr:CCP43232,GOA:P9WKU3,NCBI_GP:CCP43232.1;Name=CCP43232.1;Note=Rv0497%2C (MTCY20G9.23)%2C len: 310 aa. Probable conserved transmembrane protein%2C equivalent (but shorter in C-terminus) to P54580|Y497_MYCLE|ML2433 hypothetical 37.9 KDA protein from Mycobacterium leprae (355 aa). N-terminus highly similar to S72922|B2168_C1_166|467074 hypothetical protein from Mycobacterium leprae (118 aa)%2C FASTA scores: opt: 350%2C E(): 1.4e-12%2C (57.9%25 identity in 114 aa overlap)%3B and hydrophobic C-terminus%2C highly similar to S72895|B2168_C2_209|467047 hypothetical protein from Mycobacterium leprae (241 aa)%2C FASTA scores: opt: 473%2C E(): 8e-19%2C (53.9%25 identity in 241 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0497;product=Probable conserved transmembrane protein;protein_id=CCP43232.1;transl_table=11
AL123456.3	EMBL	gene	588325	589167	.	+	.	ID=gene-Rv0498;Name=Rv0498;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0498
AL123456.3	EMBL	CDS	588325	589167	.	+	0	ID=cds-CCP43233.1;Parent=gene-Rv0498;Dbxref=EnsemblGenomes-Gn:Rv0498,EnsemblGenomes-Tr:CCP43233,InterPro:IPR013022,NCBI_GP:CCP43233.1;Name=CCP43233.1;Note=Rv0498%2C (MTCY20G9.24)%2C len: 280 aa. Conserved hypothetical protein%2C highly similar to P54581|Y498_MYCLE|ML2432 hypothetical 30.5 KDA protein from Mycobacterium leprae (280 aa)%3B and S72896|B2168_C2_210 hypothetical protein from Mycobacterium leprae (244 aa)%2CFASTA scores: opt: 1486%2C E():0%2C (89.3%25 identity in 244 aa overlap). Also similar to Q9X8H0|Y714_STRCO|SCE7.14c hypothetical protein from Streptomyces coelicolor.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0498;product=Conserved hypothetical protein;protein_id=CCP43233.1;transl_table=11
AL123456.3	EMBL	gene	589183	590058	.	+	.	ID=gene-Rv0499;Name=Rv0499;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0499
AL123456.3	EMBL	CDS	589183	590058	.	+	0	ID=cds-CCP43234.1;Parent=gene-Rv0499;Dbxref=EnsemblGenomes-Gn:Rv0499,EnsemblGenomes-Tr:CCP43234,GOA:P9WKT9,InterPro:IPR001206,InterPro:IPR029069,NCBI_GP:CCP43234.1;Name=CCP43234.1;Note=Rv0499%2C (MTCY20G9.25)%2C len: 291 aa. Conserved hypothetical protein%2C showing some similarity to AL031184|SC2A11_16|T34762 hypothetical protein from Streptomyces coelicolor (340 aa)%2C FASTA scores: opt: 240%2CE(): 1.8e-07%2C (28.9%25 identity in 270 aa overlap).;gbkey=CDS;locus_tag=Rv0499;product=Conserved hypothetical protein;protein_id=CCP43234.1;transl_table=11
AL123456.3	EMBL	gene	590083	590970	.	+	.	ID=gene-Rv0500;Name=proC;gbkey=Gene;gene=proC;gene_biotype=protein_coding;locus_tag=Rv0500
AL123456.3	EMBL	CDS	590083	590970	.	+	0	ID=cds-CCP43235.1;Parent=gene-Rv0500;Dbxref=EnsemblGenomes-Gn:Rv0500,EnsemblGenomes-Tr:CCP43235,GOA:P9WHU7,InterPro:IPR000304,InterPro:IPR008927,InterPro:IPR016040,InterPro:IPR028939,InterPro:IPR029036,NCBI_GP:CCP43235.1;Name=CCP43235.1;Note=Rv0500%2C (MTCY20G9.26)%2C len: 295 aa. Probable proC%2CPyrroline-5-carboxylate reductase (see citation below)%2Cequivalent to P46725|PROC_MYCLE pyrroline-5-carboxylate reductase from Mycobacterium leprae (294 aa)%2C FASTA scores: opt: 1473%2C E(): 0%2C (82.4%25 identity in 295 aa overlap). Also similar to others e.g. P46540|PROC_CORGL pyrroline-5-carboxylate reductase from Corynebacterium glutamicum (270 aa)%3B T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate reductase from Streptomyces coelicolor (284 aa)%3B etc. Belongs to the pyrroline-5-carboxylate reductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=proC;locus_tag=Rv0500;product=Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase);protein_id=CCP43235.1;transl_table=11
AL123456.3	EMBL	gene	591111	591347	.	+	.	ID=gene-Rv0500A;Name=Rv0500A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0500A
AL123456.3	EMBL	CDS	591111	591347	.	+	0	ID=cds-CCP43236.1;Parent=gene-Rv0500A;Dbxref=EnsemblGenomes-Gn:Rv0500A,EnsemblGenomes-Tr:CCP43236,GOA:P9WKT7,InterPro:IPR009061,InterPro:IPR010093,NCBI_GP:CCP43236.1;Name=CCP43236.1;Note=Rv0500A%2C len: 78 aa. Conserved protein%2C similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid B2168 (86 aa)%2C FASTA scores: opt: 428%2C E(): 1.3e-27%2C (82.6%25 identity in 86 aa overlap)%3B AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 (70 aa)%2C FASTA scores: opt: 252%2C E(): 1.2 e-13%2C (72.2 identity in 54 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0500A;product=Conserved protein;protein_id=CCP43236.1;transl_table=11
AL123456.3	EMBL	gene	591475	591576	.	+	.	ID=gene-Rv0500B;Name=Rv0500B;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0500B
AL123456.3	EMBL	CDS	591475	591576	.	+	0	ID=cds-CCP43237.1;Parent=gene-Rv0500B;Dbxref=EnsemblGenomes-Gn:Rv0500B,EnsemblGenomes-Tr:CCP43237,InterPro:IPR013177,NCBI_GP:CCP43237.1;Name=CCP43237.1;Note=Rv0500B%2C len: 33 aa. Conserved hypothetical protein. Basic protein 18 of the 33 aa are Arg or Lys%2C with strong similarity to AL079345|SCE68_25 protein from Streptomyces coelicolor cosmid E6 (32 aa)%2C FASTA scores: opt: 176%2C E(): 1e-06%2C (93.1%25 identity in 29 aa overlap). Same gene arrangement in both actinomycetes.;gbkey=CDS;locus_tag=Rv0500B;product=Conserved hypothetical protein;protein_id=CCP43237.1;transl_table=11
AL123456.3	EMBL	gene	591654	592784	.	+	.	ID=gene-Rv0501;Name=galE2;gbkey=Gene;gene=galE2;gene_biotype=protein_coding;gene_synonym=galE1;locus_tag=Rv0501
AL123456.3	EMBL	CDS	591654	592784	.	+	0	ID=cds-CCP43238.1;Parent=gene-Rv0501;Dbxref=EnsemblGenomes-Gn:Rv0501,EnsemblGenomes-Tr:CCP43238,GOA:P9WKT3,InterPro:IPR001509,InterPro:IPR016040,NCBI_GP:CCP43238.1;Name=CCP43238.1;Note=Rv0501%2C (MTCY20G9.28)%2C len: 376 aa. Possible galE2%2CUDP-glucose 4-epimerase%2C highly similar (except in N-terminus) to CAC31944.1|AL583925 possible glucose epimerase/dehydratase from Mycobacterium leprae (364 aa). N-terminus highly similar to S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical protein from Mycobacterium leprae (180 aa)%2C FASTA scores: opt: 934%2C E(): 0%2C (89.6%25 identity in 164 aa overlap)%3B and C-terminus highly similar to S72898|467050|AAA17234.1|U00018 hypothetical protein from Mycobacterium leprae (168 aa)%2C FASTA scores: opt: 928%2C E(): 0%2C (82.7%25 identity in 168 aa overlap). Also highly similar to T36274|5123671|CAB45360.1|AL079345 probable epimerase from Streptomyces coelicolor (353 aa)%3B and similar in part to other epimerases e.g. GALE_ECOLI|P09147 UDP-glucose 4-epimerase from Escherichia coli (338 aa)%2C FASTA scores: opt: 241%2C E(): 6.7e-09%2C (28.2%25 identity in 294 aa overlap)%3B etc. Belongs to the sugar epimerase family. Cofactor: NAD. Note that previously known as galE1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=galE2;locus_tag=Rv0501;product=Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase);protein_id=CCP43238.1;transl_table=11
AL123456.3	EMBL	gene	592791	593867	.	+	.	ID=gene-Rv0502;Name=Rv0502;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0502
AL123456.3	EMBL	CDS	592791	593867	.	+	0	ID=cds-CCP43239.1;Parent=gene-Rv0502;Dbxref=EnsemblGenomes-Gn:Rv0502,EnsemblGenomes-Tr:CCP43239,GOA:P9WKT1,InterPro:IPR002123,InterPro:IPR016676,NCBI_GP:CCP43239.1;Name=CCP43239.1;Note=Rv0502%2C (MTCY20G9.29)%2C len: 358 aa. Conserved protein%2C equivalent to P54878|Y502_MYCLE|ML2427 hypothetical 40.5 KDA protein from Mycobacterium leprae (367 aa)%2C FASTA scores: opt: 2042%2C E(): 0%2C (84.1%25 identity in 365 aa overlap). Also similar to T36273|SCE68.23c hypothetical protein from Streptomyces coelicolor (355 aa). C-terminal similar to AL021529|SC10A5_4|T34572 hypothetical protein from Streptomyces coelicolor (295 aa)%2C FASTA score: (57.8%25 identity in 263 aa overlap)%3B and to hypothetical proteins from Mycobacterium tuberculosis Rv1920|G70808 (287 aa)%3B and Rv1428c|G70914 (275 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0502;product=Conserved protein;protein_id=CCP43239.1;transl_table=11
AL123456.3	EMBL	gene	593871	594779	.	-	.	ID=gene-Rv0503c;Name=cmaA2;gbkey=Gene;gene=cmaA2;gene_biotype=protein_coding;gene_synonym=cma2;locus_tag=Rv0503c
AL123456.3	EMBL	CDS	593871	594779	.	-	0	ID=cds-CCP43240.1;Parent=gene-Rv0503c;Dbxref=EnsemblGenomes-Gn:Rv0503c,EnsemblGenomes-Tr:CCP43240,GOA:P9WPB5,InterPro:IPR003333,InterPro:IPR029063,PDB:1KPI,PDB:3HEM,NCBI_GP:CCP43240.1;Name=CCP43240.1;Note=Rv0503c%2C (MTCY20G9.30c)%2C len: 302 aa. CmaA2 (alternate gene name: cma2)%2Ccyclopropane-fatty-acyl-phospholipid synthase 2 (mycolic acid trans-cyclopropane synthetase) (see citations below). Note that this protein has 302 aa and not 322 aa: we have chosen a different initiation codon on the basis of homology. Equivalent to S72886|B2168_F3_130 hypothetical protein from Mycobacterium leprae (308 aa)%2C FASTA score: (78.9%25 identity in 303 aa overlap)%3B and highly similar to other proteins from Mycobacterium leprae. Also similar to other proteins from Mycobacterium tuberculosis and Mycobacterium bovis BCG e.g. MTV038_14|UMAA2|Rv0470c|MTV038.14 putative mycolic acid synthesis/modification protein (287 aa) (57.2%25 identity in 297 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cmaA2;locus_tag=Rv0503c;product=Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase);protein_id=CCP43240.1;transl_table=11
AL123456.3	EMBL	gene	594802	595302	.	-	.	ID=gene-Rv0504c;Name=Rv0504c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0504c
AL123456.3	EMBL	CDS	594802	595302	.	-	0	ID=cds-CCP43241.1;Parent=gene-Rv0504c;Dbxref=EnsemblGenomes-Gn:Rv0504c,EnsemblGenomes-Tr:CCP43241,GOA:P9WFK3,InterPro:IPR016709,InterPro:IPR029069,NCBI_GP:CCP43241.1;Name=CCP43241.1;Note=Rv0504c%2C (MTCY20G9.31c)%2C len: 166 aa. Conserved protein%2C equivalent to P54879|Y504_MYCLE|ML2425 hypothetical 18.7 KDA protein from Mycobacterium leprae (166 aa)%2C FASTA scores: opt: 884%2C E(): 0%2C (83.1%25 identity in 166 aa overlap)%3B and highly similar to other proteins from Mycobacterium leprae. Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). Also similar to M. tuberculosis hypothetical proteins Rv0635|H70612 (158 aa)%3B and Rv0637|B70613 (166 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0504c;product=Conserved protein;protein_id=CCP43241.1;transl_table=11
AL123456.3	EMBL	gene	595464	596585	.	-	.	ID=gene-Rv0505c;Name=serB1;gbkey=Gene;gene=serB1;gene_biotype=protein_coding;gene_synonym=serB;locus_tag=Rv0505c
AL123456.3	EMBL	CDS	595464	596585	.	-	0	ID=cds-CCP43242.1;Parent=gene-Rv0505c;Dbxref=EnsemblGenomes-Gn:Rv0505c,EnsemblGenomes-Tr:CCP43242,GOA:P9WGJ3,InterPro:IPR006383,InterPro:IPR006385,InterPro:IPR023214,NCBI_GP:CCP43242.1;Name=CCP43242.1;Note=Rv0505c%2C (MTCY20G9.32c)%2C len: 373 aa. Possible serB1%2C phosphoserine phosphatase%2C equivalent (but longer ~~70 aa in N-terminus) to S72914|serB phosphoserine phosphatase from Mycobacterium leprae (300 aa)%2C FASTA scores: opt: 1570%2C E(): 0%2C (83.0%25 identity in 306 aa overlap). C-terminus highly similar to CAB55344.1|AJ010584 phosphoserine phosphatase from Streptomyces coelicolor (266 aa). Low similarity to SERB_ECOLI|P06862 phosphoserine phosphatase from Escherichia coli strains K12 and O157:H7 (322 aa)%2C FASTA scores: opt: 148%2C E(): 0.043%2C (24.0%25 identity in 150 aa overlap). C-terminus is also similar to O33611|AB004855_1|IMD_STRCN protein involved in inhibition of morphological differentiation from Streptomyces cyaneus (277 aa)%2C FASTA score: (37.7%25 identity in 252 aa overlap). Seems to belong to the SERB family. Note that previously known as serB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=serB1;locus_tag=Rv0505c;product=Possible phosphoserine phosphatase SerB1 (PSP) (O-phosphoserine phosphohydrolase) (pspase);protein_id=CCP43242.1;transl_table=11
AL123456.3	EMBL	gene	596759	597202	.	+	.	ID=gene-Rv0506;Name=mmpS2;gbkey=Gene;gene=mmpS2;gene_biotype=protein_coding;locus_tag=Rv0506
AL123456.3	EMBL	CDS	596759	597202	.	+	0	ID=cds-CCP43243.1;Parent=gene-Rv0506;Dbxref=EnsemblGenomes-Gn:Rv0506,EnsemblGenomes-Tr:CCP43243,GOA:P9WJT3,InterPro:IPR008693,NCBI_GP:CCP43243.1;Name=CCP43243.1;Note=Rv0506%2C (MTCY20G9.33)%2C len: 147 aa. Probable mmpS2%2Cconserved membrane protein (see citation below)%2C highly similar to other Mycobacterial proteins e.g. C-terminus of AAD44232.1|AF143772_38|AF143772|TmtpA from Mycobacterium avium (221 aa)%3B P54880|MMS4_MYCLE|MMPS4 putative membrane protein from Mycobacterium leprae (154 aa)%2C FASTA scores: opt: 392%2C E(): 1.3e-20%2C (43.7%25 identity in 151 aa overlap)%3B and the putative membrane proteins from Mycobacterium tuberculosis MTV040_5%2C MTCY4D9_16%2C MTV037_15. Belongs to the MmpS family. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpS2;locus_tag=Rv0506;product=Probable conserved membrane protein MmpS2;protein_id=CCP43243.1;transl_table=11
AL123456.3	EMBL	gene	597199	600105	.	+	.	ID=gene-Rv0507;Name=mmpL2;gbkey=Gene;gene=mmpL2;gene_biotype=protein_coding;locus_tag=Rv0507
AL123456.3	EMBL	CDS	597199	600105	.	+	0	ID=cds-CCP43244.1;Parent=gene-Rv0507;Dbxref=EnsemblGenomes-Gn:Rv0507,EnsemblGenomes-Tr:CCP43244,GOA:P9WJV7,InterPro:IPR004707,InterPro:IPR004869,NCBI_GP:CCP43244.1;Name=CCP43244.1;Note=Rv0507%2C (MTCY20G9.34)%2C len: 968 aa. Probable mmpL2%2Cconserved transmembrane transport protein (see citations below)%2C member of RND superfamily%2C highly similar to other Mycobacterial proteins e.g. YV34_MYCLE from Mycobacterium leprae (959 aa)%2C FASTA scores: opt: 3699%2C E(): 0%2C (58.3%25 identity in 940 aa overlap)%3B and the Mycobacterium tuberculosis proteins MTV037_14%2C MTV040_4%2C MTCY98_8%2CMTCY4D9_15%2C MTCY48_8%2C MTCY19G5_6%2C MTV005_19%2C etc. Also similar to STMACTII_3|SC10A5_9 from Streptomyces coelicolor%3B and BSUB0|004_12 from Bacillus subtilis. C-terminal half similar to Q50086|U1740AB from Mycobacterium leprae (386 aa)%2C FASTA scores: opt: 1526%2CE(): 0%2C (61.5%25 identity in 371 aa overlap). Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL2;locus_tag=Rv0507;product=Probable conserved transmembrane transport protein MmpL2;protein_id=CCP43244.1;transl_table=11
AL123456.3	EMBL	gene	600098	600391	.	+	.	ID=gene-Rv0508;Name=Rv0508;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0508
AL123456.3	EMBL	CDS	600098	600391	.	+	0	ID=cds-CCP43245.1;Parent=gene-Rv0508;Dbxref=EnsemblGenomes-Gn:Rv0508,EnsemblGenomes-Tr:CCP43245,GOA:P9WKS9,InterPro:IPR008554,InterPro:IPR012336,NCBI_GP:CCP43245.1;Name=CCP43245.1;Note=Rv0508%2C (MTCY20G9.35)%2C len: 97 aa. Conserved hypothetical protein%2C showing similarity with T36269|5123666|CAB45355.1|AL079345 probable redoxin from Streptomyces coelicolor (101 aa)%2C FASTA scores: opt: 160%2CE(): 3.4e-05%2C (33.3%25 identity in 75 aa overlap)%3B and E81943|NMA0966 probable thioredoxin from Neisseria meningitidis group a strain Z2491 (77 aa).;gbkey=CDS;locus_tag=Rv0508;product=Conserved hypothetical protein;protein_id=CCP43245.1;transl_table=11
AL123456.3	EMBL	gene	600441	601847	.	+	.	ID=gene-Rv0509;Name=hemA;gbkey=Gene;gene=hemA;gene_biotype=protein_coding;locus_tag=Rv0509
AL123456.3	EMBL	CDS	600441	601847	.	+	0	ID=cds-CCP43246.1;Parent=gene-Rv0509;Dbxref=EnsemblGenomes-Gn:Rv0509,EnsemblGenomes-Tr:CCP43246,GOA:P9WMP7,InterPro:IPR000343,InterPro:IPR006151,InterPro:IPR015895,InterPro:IPR015896,InterPro:IPR016040,InterPro:IPR018214,NCBI_GP:CCP43246.1;Name=CCP43246.1;Note=Rv0509%2C (MTCY20G9.36)%2C len: 468 aa. Probable hemA%2Cglutamyl-tRNA reductase%2C equivalent to HEM1_MYCLE|P46724 glutamyl-tRNA reductase from Mycobacterium leprae (467 aa)%2CFASTA scores: opt: 2377%2C E(): 0%2C (82.3%25 identity in 463 aa overlap). Also highly similar (sometimes in part) to others e.g. Q9WX15|HEM1_STRCO glutamyl-tRNA reductase from Streptomyces coelicolor (581 aa)%3B P16618|HEM1_BACSU|HEMA glutamyl-tRNA reductase from Bacillus subtilis (455 aa)%3B etc. Contains PS00747 Glutamyl-tRNA reductase signature. Belongs to the glutamyl-tRNA reductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemA;inference=protein motif:PROSITE:PS00747;locus_tag=Rv0509;product=Probable glutamyl-tRNA reductase HemA (GLUTR);protein_id=CCP43246.1;transl_table=11
AL123456.3	EMBL	gene	601857	602786	.	+	.	ID=gene-Rv0510;Name=hemC;gbkey=Gene;gene=hemC;gene_biotype=protein_coding;locus_tag=Rv0510
AL123456.3	EMBL	CDS	601857	602786	.	+	0	ID=cds-CCP43247.1;Parent=gene-Rv0510;Dbxref=EnsemblGenomes-Gn:Rv0510,EnsemblGenomes-Tr:CCP43247,GOA:P9WMP3,InterPro:IPR000860,InterPro:IPR022417,InterPro:IPR022418,InterPro:IPR022419,NCBI_GP:CCP43247.1;Name=CCP43247.1;Note=Rv0510%2C (MTCY21C8.01-MTCY20G9.37)%2C len: 309 aa. Probable hemC%2C hydroxymethylbilane synthase (porphobilinogen deaminase)%2C equivalent to HEM3B|Q49808|HEM3_MYCLE porphobilinogen deaminase from Mycobacterium leprae (315 aa)%2C FASTA scores: opt: 889%2C E(): 0%2C (88.1%25 identity in 159 aa overlap). Also highly similar to others e.g. Q9WX16|HE31_STRCO probable porphobilinogen deaminase from Streptomyces coelicolor (319 aa)%3B Q9L6Q2|HEM3_SALTY porphobilinogen deaminase from Salmonella typhimurium (313 aa)%3B etc. Belongs to the HMBS family. Cofactor: covalently binds a dipyrromethane cofactor to which the porphobilinogen subunits are ADDED.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemC;locus_tag=Rv0510;product=Probable porphobilinogen deaminase HemC (PBG) (hydroxymethylbilane synthase) (HMBS) (pre-uroporphyrinogen synthase);protein_id=CCP43247.1;transl_table=11
AL123456.3	EMBL	gene	602819	604516	.	+	.	ID=gene-Rv0511;Name=hemD;gbkey=Gene;gene=hemD;gene_biotype=protein_coding;gene_synonym=cysG;locus_tag=Rv0511
AL123456.3	EMBL	CDS	602819	604516	.	+	0	ID=cds-CCP43248.1;Parent=gene-Rv0511;Dbxref=EnsemblGenomes-Gn:Rv0511,EnsemblGenomes-Tr:CCP43248,GOA:Q6MX34,InterPro:IPR000878,InterPro:IPR003754,InterPro:IPR014776,InterPro:IPR014777,UniProtKB/TrEMBL:Q6MX34,NCBI_GP:CCP43248.1;Name=CCP43248.1;Note=Rv0511%2C (MTCY21C8.02)%2C len: 565 aa. Probable hemD (alternate gene name: cysG)%2C uroporphyrin-III C-methyltransferase%2C highly similar to others e.g. CAC31936.1|AL583925 possible uroporphyrin-III C-methyltransferase from Mycobacterium leprae (563 aa)%3B and S72909|CYSG from Mycobacterium leprae (472 aa)%2C FASTA scores: opt: 1946%2C E(): 0%2C (83.3%25 identity in 472 aa overlap)%3B T36265|5123662|CAB45351.1|AL079345 probable uroporphyrin-III C-methyltransferase from Streptomyces coelicolor (565 aa)%3B and similar to others e.g. AAK00606.1|AF221100_3|AF221100 from Selenomonas ruminantium subsp. ruminantium (505 aa)%3B etc. Also similar to Rv2071c and Rv2847c from Mycobacterium tuberculosis. Note that previously known as cysG.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemD;locus_tag=Rv0511;product=Probable uroporphyrin-III C-methyltransferase HemD (uroporphyrinogen III methylase) (urogen III methylase) (SUMT) (urogen III methylase) (UROM);protein_id=CCP43248.1;transl_table=11
AL123456.3	EMBL	gene	604602	605591	.	+	.	ID=gene-Rv0512;Name=hemB;gbkey=Gene;gene=hemB;gene_biotype=protein_coding;locus_tag=Rv0512
AL123456.3	EMBL	CDS	604602	605591	.	+	0	ID=cds-CCP43249.1;Parent=gene-Rv0512;Dbxref=EnsemblGenomes-Gn:Rv0512,EnsemblGenomes-Tr:CCP43249,GOA:P9WMP5,InterPro:IPR001731,InterPro:IPR013785,NCBI_GP:CCP43249.1;Name=CCP43249.1;Note=Rv0512%2C (MTCY20G10.02)%2C len: 329 aa. Probable hemB%2Cdelta-aminolevulinic acid dehydratase%2C equivalent to 46723|HEM2_MYCLE delta-aminolevulinic acid dehydratase from Mycobacterium leprae (329 aa). Also highly similar to many e.g. P54919|HEM2_STRCO from Streptomyces coelicolor (330 aa)%3B HEM2_ECOLI|P15002 from Escherichia coli (323 aa)%2CFASTA scores: opt: 942%2C E(): 0%2C (47.6%25 identity in 317 aa overlap)%3B etc. Contains PS00169 Delta-aminolevulinic acid dehydratase active site. Belongs to the ALADH family. Cofactor: zinc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemB;inference=protein motif:PROSITE:PS00169;locus_tag=Rv0512;product=Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH);protein_id=CCP43249.1;transl_table=11
AL123456.3	EMBL	gene	605604	606152	.	+	.	ID=gene-Rv0513;Name=Rv0513;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0513
AL123456.3	EMBL	CDS	605604	606152	.	+	0	ID=cds-CCP43250.1;Parent=gene-Rv0513;Dbxref=EnsemblGenomes-Gn:Rv0513,EnsemblGenomes-Tr:CCP43250,GOA:O33358,InterPro:IPR016844,UniProtKB/TrEMBL:O33358,NCBI_GP:CCP43250.1;Name=CCP43250.1;Note=Rv0513%2C (MTCY20G10.03)%2C len: 182 aa. Possible conserved transmembrane protein%2C with its N-terminus highly similar to S72925|B2168_C1_182 hypothetical protein from Mycobacterium leprae (103 aa)%2C FASTA scores: opt: 217%2C E(): 8.2e-14%2C (45.3 %25 identity in 106 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0513;product=Possible conserved transmembrane protein;protein_id=CCP43250.1;transl_table=11
AL123456.3	EMBL	gene	606149	606448	.	+	.	ID=gene-Rv0514;Name=Rv0514;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0514
AL123456.3	EMBL	CDS	606149	606448	.	+	0	ID=cds-CCP43251.1;Parent=gene-Rv0514;Dbxref=EnsemblGenomes-Gn:Rv0514,EnsemblGenomes-Tr:CCP43251,GOA:O33359,UniProtKB/TrEMBL:O33359,NCBI_GP:CCP43251.1;Name=CCP43251.1;Note=Rv0514%2C (MTCY20G10.04)%2C len: 99 aa. Possible transmembrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0514;product=Possible transmembrane protein;protein_id=CCP43251.1;transl_table=11
AL123456.3	EMBL	gene	606551	608062	.	+	.	ID=gene-Rv0515;Name=Rv0515;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0515
AL123456.3	EMBL	CDS	606551	608062	.	+	0	ID=cds-CCP43252.1;Parent=gene-Rv0515;Dbxref=EnsemblGenomes-Gn:Rv0515,EnsemblGenomes-Tr:CCP43252,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:O33360,NCBI_GP:CCP43252.1;Name=CCP43252.1;Note=Rv0515%2C (MTCY20G10.05)%2C len: 503 aa. Part of M. tuberculosis 13E12 repeat family. Almost identical to Rv0336 (99.8%25 identity in 503 aa overlap)%2C possibly due to a recent gene duplication. Also similar to other M. tuberculosis hypothetical 13E12 repeat proteins e.g. Rv1148c%2C Rv1945%2C etc.;gbkey=CDS;locus_tag=Rv0515;product=Conserved 13E12 repeat family protein;protein_id=CCP43252.1;transl_table=11
AL123456.3	EMBL	gene	608059	608535	.	-	.	ID=gene-Rv0516c;Name=Rv0516c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0516c
AL123456.3	EMBL	CDS	608059	608535	.	-	0	ID=cds-CCP43253.1;Parent=gene-Rv0516c;Dbxref=EnsemblGenomes-Gn:Rv0516c,EnsemblGenomes-Tr:CCP43253,GOA:O33361,InterPro:IPR002645,UniProtKB/TrEMBL:O33361,NCBI_GP:CCP43253.1;Name=CCP43253.1;Note=Rv0516c%2C (MTCY20G10.06c)%2C len: 158 aa. Possible anti-anti-sigma factor%2C showing some similarity to Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 aa)%2C FASTA scores: E(): 0.0012%2C (27.4%25 identity in 124 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0516c;product=Possible anti-anti-sigma factor;protein_id=CCP43253.1;transl_table=11
AL123456.3	EMBL	gene	608746	610056	.	+	.	ID=gene-Rv0517;Name=Rv0517;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0517
AL123456.3	EMBL	CDS	608746	610056	.	+	0	ID=cds-CCP43254.1;Parent=gene-Rv0517;Dbxref=EnsemblGenomes-Gn:Rv0517,EnsemblGenomes-Tr:CCP43254,GOA:O33362,InterPro:IPR002656,UniProtKB/TrEMBL:O33362,NCBI_GP:CCP43254.1;Name=CCP43254.1;Note=Rv0517%2C (MTCY20G10.07)%2C len: 436 aa. Possible acyltransferase%2C integral membrane protein%2C equivalent (but longer 26 aa in N-terminus) to AAK44761.1|AE006954 putative acyltransferase from Mycobacterium tuberculosis strain CDC1551 (410 aa). Also similar to many acyltransferases e.g. MDMB_STRMY|Q00718 from Streptomyces mycarofaciens (387 aa)%2C FASTA scores: opt: 200%2C E(): 1.1e-08%2C (28.2%25 identity in 394 aa overlap). And similar to Rv0111%2C Rv0228%2C Rv1254%2CRv1565c from Mycobacterium tuberculosis.;gbkey=CDS;locus_tag=Rv0517;product=Possible membrane acyltransferase;protein_id=CCP43254.1;transl_table=11
AL123456.3	EMBL	gene	610188	610883	.	+	.	ID=gene-Rv0518;Name=Rv0518;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0518
AL123456.3	EMBL	CDS	610188	610883	.	+	0	ID=cds-CCP43255.1;Parent=gene-Rv0518;Dbxref=EnsemblGenomes-Gn:Rv0518,EnsemblGenomes-Tr:CCP43255,GOA:O33363,InterPro:IPR013831,UniProtKB/TrEMBL:O33363,NCBI_GP:CCP43255.1;Name=CCP43255.1;Note=Rv0518%2C (MTCY20G10.08)%2C len: 231 aa. Possible exported protein%3B has hydrophobic N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0518;product=Possible exported protein;protein_id=CCP43255.1;transl_table=11
AL123456.3	EMBL	gene	611172	612074	.	-	.	ID=gene-Rv0519c;Name=Rv0519c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0519c
AL123456.3	EMBL	CDS	611172	612074	.	-	0	ID=cds-CCP43256.1;Parent=gene-Rv0519c;Dbxref=EnsemblGenomes-Gn:Rv0519c,EnsemblGenomes-Tr:CCP43256,GOA:O33364,InterPro:IPR000801,InterPro:IPR006311,InterPro:IPR029058,UniProtKB/TrEMBL:O33364,NCBI_GP:CCP43256.1;Name=CCP43256.1;Note=Rv0519c%2C (MTCY20G10.09c)%2C len: 300 aa. Possible conserved membrane protein%2C with hydrophobic region near N-terminus. Could be a lipase. Similar to Rv0774c|MTCY369.19c|A70708 from Mycobacterium tuberculosis (312 aa)%2C FASTA scores: opt: 1092%2C E(): 0%2C (57.9%25 identity in 299 aa overlap). Contains PS00120 Lipases%2C serine active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv0519c;product=Possible conserved membrane protein;protein_id=CCP43256.1;transl_table=11
AL123456.3	EMBL	gene	612255	612605	.	+	.	ID=gene-Rv0520;Name=Rv0520;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0520
AL123456.3	EMBL	CDS	612255	612605	.	+	0	ID=cds-CCP43257.1;Parent=gene-Rv0520;Dbxref=EnsemblGenomes-Gn:Rv0520,EnsemblGenomes-Tr:CCP43257,GOA:O33365,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:O33365,NCBI_GP:CCP43257.1;Name=CCP43257.1;Note=Rv0520%2C (MTCY20G10.10)%2C len: 116 aa. Possible fragment of methyltransferase (possibly first part)%2C highly similar to part of several methyltransferases e.g. Q43445|U43683 S-adenosyl-L-methionine:DELTA24-sterol-C-methyltransferase from Glycine max (Soybean)(367 aa)%2C FASTA scores: opt: 190%2CE(): 2.3e-12%2C (39.2%25 identity in 74 aa overlap). Also some similarity to MTCY19G5_5 from Mycobacterium tuberculosis. Possibly continues as Rv0521 but we can find no frameshift to account for this.;gbkey=CDS;locus_tag=Rv0520;product=Possible methyltransferase/methylase (fragment);protein_id=CCP43257.1;transl_table=11
AL123456.3	EMBL	gene	612598	612903	.	+	.	ID=gene-Rv0521;Name=Rv0521;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0521
AL123456.3	EMBL	CDS	612598	612903	.	+	0	ID=cds-CCP43258.1;Parent=gene-Rv0521;Dbxref=EnsemblGenomes-Gn:Rv0521,EnsemblGenomes-Tr:CCP43258,GOA:L7N6C0,InterPro:IPR023143,InterPro:IPR029063,UniProtKB/TrEMBL:L7N6C0,NCBI_GP:CCP43258.1;Name=CCP43258.1;Note=Rv0521%2C (replaces MTCY20G10.11)%2C len: 101 aa. Possible fragment of methyltransferase (possibly second part)%2C highly similar to C-terminus of several methyltransferases e.g. AAF87203.1|AF216282 sarcosine-dimethylglycine methyltransferase from Halorhodospira halochloris (279 aa). Possibly continuation of Rv0520 but we can find no frameshift to account for this.;gbkey=CDS;locus_tag=Rv0521;product=Possible methyltransferase/methylase (fragment);protein_id=CCP43258.1;transl_table=11
AL123456.3	EMBL	gene	613038	614342	.	+	.	ID=gene-Rv0522;Name=gabP;gbkey=Gene;gene=gabP;gene_biotype=protein_coding;locus_tag=Rv0522
AL123456.3	EMBL	CDS	613038	614342	.	+	0	ID=cds-CCP43259.1;Parent=gene-Rv0522;Dbxref=EnsemblGenomes-Gn:Rv0522,EnsemblGenomes-Tr:CCP43259,GOA:L7N6B9,InterPro:IPR002293,InterPro:IPR004840,InterPro:IPR004841,UniProtKB/TrEMBL:L7N6B9,NCBI_GP:CCP43259.1;Name=CCP43259.1;Note=Rv0522%2C (MTCY20G10.12)%2C len: 434 aa. Probable gabP%2CGABA permease (gamma-aminobutyrate permease)%2C integral membrane protein%2C highly similar to others e.g. GABP_ECOLI|P25527 gaba permease from Escherichia coli (466 aa)%2C FASTA scores: opt: 1218%2C E(): 0%2C (44.3%25 identity in 424 aa overlap)%3B etc. Also similar to other M. tuberculosis permeases e.g. MTCY13E10.06c FASTA score: (34.4%25 identity in 407 aa overlap). Contains PS00218 Amino acid permeases signature. Overlaps and extends Rv0523c|MTCY25D10.01 from overlapping cosmid. Belongs to the amino acid permease family (APC family).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gabP;inference=protein motif:PROSITE:PS00218;locus_tag=Rv0522;product=Probable GABA permease GabP (4-amino butyrate transport carrier) (GAMA-aminobutyrate permease);protein_id=CCP43259.1;transl_table=11
AL123456.3	EMBL	gene	614326	614721	.	-	.	ID=gene-Rv0523c;Name=Rv0523c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0523c
AL123456.3	EMBL	CDS	614326	614721	.	-	0	ID=cds-CCP43260.1;Parent=gene-Rv0523c;Dbxref=EnsemblGenomes-Gn:Rv0523c,EnsemblGenomes-Tr:CCP43260,GOA:O06389,InterPro:IPR004378,UniProtKB/TrEMBL:O06389,NCBI_GP:CCP43260.1;Name=CCP43260.1;Note=Rv0523c%2C (MTCY25D10.02)%2C len: 131 aa. Conserved protein%2C showing some similarity to M. tuberculosis proteins Rv1598c|MTCY336.06%3B and Rv1871c|MTCY336_06|O06592 (136 aa)%2C FASTA scores: opt: 197%2C E(): 5e-08%2C (38.4%25 identity in 99 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0523c;product=Conserved protein;protein_id=CCP43260.1;transl_table=11
AL123456.3	EMBL	gene	614835	616223	.	+	.	ID=gene-Rv0524;Name=hemL;gbkey=Gene;gene=hemL;gene_biotype=protein_coding;locus_tag=Rv0524
AL123456.3	EMBL	CDS	614835	616223	.	+	0	ID=cds-CCP43261.1;Parent=gene-Rv0524;Dbxref=EnsemblGenomes-Gn:Rv0524,EnsemblGenomes-Tr:CCP43261,GOA:P9WMN9,InterPro:IPR004639,InterPro:IPR005814,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP43261.1;Name=CCP43261.1;Note=Rv0524%2C (MTCY25D10.03)%2C len: 462 aa. Probable hemL%2Cglutamate-1-semialdehyde 2%2C1-aminomutase%2C equivalent to P46716|GSA_MYCLE glutamate-1-semialdehyde 2%2C1-aminomutase from Mycobacterium leprae (446 aa)%2C FASTA scores: opt: 1532%2C E(): 0%2C (82.6%25 identity in 460 aa overlap). Also highly similar to others e.g. Q9F2S0|GSA_STRCO from Streptomyces coelicolor (438 aa)%3B Q06774|GSA_PROFR from Propionibacterium freudenreichii (441 aa)%3B etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemL;inference=protein motif:PROSITE:PS00600;locus_tag=Rv0524;product=Probable glutamate-1-semialdehyde 2%2C1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at);protein_id=CCP43261.1;transl_table=11
AL123456.3	EMBL	gene	616223	616831	.	+	.	ID=gene-Rv0525;Name=Rv0525;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0525
AL123456.3	EMBL	CDS	616223	616831	.	+	0	ID=cds-CCP43262.1;Parent=gene-Rv0525;Dbxref=EnsemblGenomes-Gn:Rv0525,EnsemblGenomes-Tr:CCP43262,GOA:O06391,InterPro:IPR013078,InterPro:IPR029033,NCBI_GP:CCP43262.1;Name=CCP43262.1;Note=Rv0525%2C (MTCY25D10.04)%2C len: 202 aa. Conserved protein%2C equivalent to Q49821|B2168_C3_276|S72912 hypothetical protein from Mycobacterium leprae (202 aa)%2CFASTA scores: opt: 1151%2C E(): 0%2C (82.5%25 identity in 200 aa overlap). Also highly similar to CAC08377.1|AL392176 putative phosphoglycerate mutase from Streptomyces coelicolor (233 aa)%3B and similar to SLL0395|Q55734 hypothetical 23.8 kDa protein from synechocystis SP. (212 aa)%2C FASTA scores: opt: 207%2C E(): 5.1e-07%2C (28.2%25 identity in 195 aa overlap). Also some similarity to Rv2228c|Y019_MYCTU|Q10512|cy427.09 hypothetical 39.2 kDa protein from Mycobacterium tuberculosis (364 aa)%2C FASTA scores: opt: 236%2C E(): 1.1e-08%2C (34.3%25 identity in 198 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0525;product=Conserved protein;protein_id=CCP43262.1;transl_table=11
AL123456.3	EMBL	repeat_region	616828	616878	.	+	.	ID=id-AL123456.3:616828..616878;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	616846	617496	.	+	.	ID=gene-Rv0526;Name=Rv0526;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0526
AL123456.3	EMBL	CDS	616846	617496	.	+	0	ID=cds-CCP43263.1;Parent=gene-Rv0526;Dbxref=EnsemblGenomes-Gn:Rv0526,EnsemblGenomes-Tr:CCP43263,GOA:O06392,InterPro:IPR000866,InterPro:IPR012336,InterPro:IPR017937,UniProtKB/TrEMBL:O06392,NCBI_GP:CCP43263.1;Name=CCP43263.1;Note=Rv0526%2C (MTCY25D10.05)%2C len: 216 aa. Possible thioredoxin protein (thiol-disulfide interchange protein) %2Cequivalent to Q49816|U2168C|S72901 hypothetical protein from Mycobacterium leprae (216 aa)%2C FASTA scores: opt: 1144%2C E(): 0%2C (78.5%25 identity in 214 aa overlap). C-terminus shows some similarity to C-terminus of thioredoxins e.g. RESA_BACSU|P35160 resa protein from Bacillus subtilis (181 aa)%2C FASTA scores: opt: 200%2C E(): 7.4e-06%2C (24.2%25 identity in 132 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis thioredoxin-like proteins Rv1470%2C Rv1471%2C Rv1677%2C etc. Contains PS00194 Thioredoxin family active site. Seems to belong to the thioredoxin family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00194;locus_tag=Rv0526;product=Possible thioredoxin protein (thiol-disulfide interchange protein);protein_id=CCP43263.1;transl_table=11
AL123456.3	EMBL	gene	617493	618272	.	+	.	ID=gene-Rv0527;Name=ccdA;gbkey=Gene;gene=ccdA;gene_biotype=protein_coding;gene_synonym=ccsA;locus_tag=Rv0527
AL123456.3	EMBL	CDS	617493	618272	.	+	0	ID=cds-CCP43264.1;Parent=gene-Rv0527;Dbxref=EnsemblGenomes-Gn:Rv0527,EnsemblGenomes-Tr:CCP43264,GOA:L7N671,InterPro:IPR003834,UniProtKB/TrEMBL:L7N671,NCBI_GP:CCP43264.1;Name=CCP43264.1;Note=Rv0527%2C (MTCY25D10.06)%2C len: 259 aa. Possible ccdA%2Ccytochrome C-type biogenesis protein%2C integral membrane protein%2C equivalent to Q49810|B2168_C1_192|S72890 hypothetical protein from Mycobacterium leprae (262 aa)%2CFASTA scores: opt: 1341%2C E(): 0%2C (79.0%25 identity in 262 aa overlap). Also highly similar to others e.g. CAC08380.1 (253 aa)%3B CCDA_BACSU|P45706 cytochrome C-type biogenesis protein from Bacillus subtilis (235 aa)%2C FASTA scores: opt: 307%2C E(): 7.4e-13%2C (30.4%25 identity in 237 aa overlap)%3B etc. Seems to belong to the DSBD subfamily. Note that previously known as ccsA.;gbkey=CDS;gene=ccdA;locus_tag=Rv0527;product=Possible cytochrome C-type biogenesis protein CcdA;protein_id=CCP43264.1;transl_table=11
AL123456.3	EMBL	gene	618305	619894	.	+	.	ID=gene-Rv0528;Name=Rv0528;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0528
AL123456.3	EMBL	CDS	618305	619894	.	+	0	ID=cds-CCP43265.1;Parent=gene-Rv0528;Dbxref=EnsemblGenomes-Gn:Rv0528,EnsemblGenomes-Tr:CCP43265,GOA:O06394,InterPro:IPR007816,UniProtKB/TrEMBL:O06394,NCBI_GP:CCP43265.1;Name=CCP43265.1;Note=Rv0528%2C (MTCY25D10.07)%2C len: 529 aa. Probable conserved transmembrane protein%2C equivalent (shorter 14 aa in N-terminus) to CAC31926.1|AL583925 conserved membrane protein from Mycobacterium leprae (542 aa). Also highly similar to Q49817|B2168_C2_237|S72902 hypothetical protein from Mycobacterium leprae (364 aa)%2C FASTA scores: opt: 1846%2C E(): 0%2C (81.1%25 identity in 338 aa overlap)%3B and Q49811|B2168_C1_194|S72891 hypothetical protein from Mycobacterium leprae (106 aa)%2C FASTA scores: opt: 506%2C E(): 3.8e-26%2C (73.6%25 identity in 106 aa overlap). Also highly similar to CAC08381.1|AL392176 putative integral membrane protein from Streptomyces coelicolor (574 aa).;gbkey=CDS;locus_tag=Rv0528;product=Probable conserved transmembrane protein;protein_id=CCP43265.1;transl_table=11
AL123456.3	EMBL	gene	619891	620865	.	+	.	ID=gene-Rv0529;Name=ccsA;gbkey=Gene;gene=ccsA;gene_biotype=protein_coding;gene_synonym=ccsB;locus_tag=Rv0529
AL123456.3	EMBL	CDS	619891	620865	.	+	0	ID=cds-CCP43266.1;Parent=gene-Rv0529;Dbxref=EnsemblGenomes-Gn:Rv0529,EnsemblGenomes-Tr:CCP43266,GOA:O06393,InterPro:IPR002541,InterPro:IPR017562,UniProtKB/TrEMBL:O06393,NCBI_GP:CCP43266.1;Name=CCP43266.1;Note=Rv0529%2C (MTCY25D10.08)%2C len: 324 aa. Possible ccsA%2Ccytochrome C-type biogenesis protein%2C integral membrane protein%2C equivalent to NP_302558.1|NC_002677|B2168_C3_281 possible cytochrome C biogenesis protein from Mycobacterium leprae (327 aa)%2C FASTA scores: opt: 1779%2C E(): 0%2C (82.9%25 identity in 327 aa overlap). Also highly similar to others e.g. CAC08382.1|AL392176 putative cytochrome biogenesis related protein from Streptomyces coelicolor (380 aa)%3B CCSA_CHLRE|P48269 probable cytochrome c biogenesis protein from Chlamydomonas reinhardtii (353 aa)%2C FASTA scores: opt: 449%2C E(): 1.3e-23%2C (34.4%25 identity in 247 aa overlap)%3B etc. Belongs to the CCMF/CYCK/CCL1/NRFE/CCSA family. Note that previously known as ccsB.;gbkey=CDS;gene=ccsA;locus_tag=Rv0529;product=Possible cytochrome C-type biogenesis protein CcsA;protein_id=CCP43266.1;transl_table=11
AL123456.3	EMBL	gene	620907	622124	.	+	.	ID=gene-Rv0530;Name=Rv0530;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0530
AL123456.3	EMBL	CDS	620907	622124	.	+	0	ID=cds-CCP43267.1;Parent=gene-Rv0530;Dbxref=EnsemblGenomes-Gn:Rv0530,EnsemblGenomes-Tr:CCP43267,InterPro:IPR025669,InterPro:IPR027417,UniProtKB/TrEMBL:O06396,NCBI_GP:CCP43267.1;Name=CCP43267.1;Note=Rv0530%2C (MTCY25D10.09)%2C len: 405 aa. Conserved protein%2C similar in part to other hypothetical proteins e.g. AL031231|SC3C3_3|CAA20252.1 from Streptomyces coelicolor (1083 aa)%2C FASTA scores: opt: 870%2C E(): 0%2C(39.5%25 identity in 443 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3868%2C Rv0282%2CRv1798%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0530;product=Conserved protein;protein_id=CCP43267.1;transl_table=11
AL123456.3	EMBL	gene	622121	622282	.	-	.	ID=gene-Rv0530A;Name=Rv0530A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0530A
AL123456.3	EMBL	CDS	622121	622282	.	-	0	ID=cds-CCP43268.1;Parent=gene-Rv0530A;Dbxref=EnsemblGenomes-Gn:Rv0530A,EnsemblGenomes-Tr:CCP43268,UniProtKB/TrEMBL:V5QPR5,NCBI_GP:CCP43268.1;Name=CCP43268.1;Note=Rv0530A%2C len: 53 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0530A;product=Conserved protein;protein_id=CCP43268.1;transl_table=11
AL123456.3	EMBL	gene	622329	622646	.	+	.	ID=gene-Rv0531;Name=Rv0531;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0531
AL123456.3	EMBL	CDS	622329	622646	.	+	0	ID=cds-CCP43269.1;Parent=gene-Rv0531;Dbxref=EnsemblGenomes-Gn:Rv0531,EnsemblGenomes-Tr:CCP43269,InterPro:IPR025323,UniProtKB/TrEMBL:O06397,NCBI_GP:CCP43269.1;Name=CCP43269.1;Note=Rv0531%2C (MTCY25D10.10)%2C len: 105 aa. Possible conserved membrane protein%2C highly similar to Y13803|MLB1306_1|CAA74131.1 hypothetical protein from Mycobacterium leprae (86 aa)%2C FASTA scores: E(): 2.1e-24%2C(74.4%25 identity in 86 aa overlap)%3B and NP_302557.1|NC_002677 putative membrane protein from Mycobacterium leprae (111 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0531;product=Possible conserved membrane protein;protein_id=CCP43269.1;transl_table=11
AL123456.3	EMBL	gene	622793	624577	.	+	.	ID=gene-Rv0532;Name=PE_PGRS6;gbkey=Gene;gene=PE_PGRS6;gene_biotype=protein_coding;locus_tag=Rv0532
AL123456.3	EMBL	CDS	622793	624577	.	+	0	ID=cds-CCP43270.1;Parent=gene-Rv0532;Dbxref=EnsemblGenomes-Gn:Rv0532,EnsemblGenomes-Tr:CCP43270,InterPro:IPR000084,UniProtKB/TrEMBL:L0T3X8,NCBI_GP:CCP43270.1;Name=CCP43270.1;Note=Rv0532%2C (MTCY25D10.11)%2C len: 594 aa. PE_PGRS6%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2Csimilar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa)%2C FASTA scores: opt: 1703%2C E(): 0%2C(58.2%25 identity in 536 aa overlap).;gbkey=CDS;gene=PE_PGRS6;locus_tag=Rv0532;product=PE-PGRS family protein PE_PGRS6;protein_id=CCP43270.1;transl_table=11
AL123456.3	EMBL	gene	624473	625480	.	-	.	ID=gene-Rv0533c;Name=fabH;gbkey=Gene;gene=fabH;gene_biotype=protein_coding;gene_synonym=mtFabH;locus_tag=Rv0533c
AL123456.3	EMBL	CDS	624473	625480	.	-	0	ID=cds-CCP43271.1;Parent=gene-Rv0533c;Dbxref=EnsemblGenomes-Gn:Rv0533c,EnsemblGenomes-Tr:CCP43271,GOA:P9WNG3,InterPro:IPR004655,InterPro:IPR013747,InterPro:IPR013751,InterPro:IPR016038,InterPro:IPR016039,PDB:1HZP,PDB:1M1M,PDB:1U6E,PDB:1U6S,PDB:2AHB,PDB:2AJ9,PDB:2QNX,PDB:2QNY,PDB:2QNZ,PDB:2QO0,PDB:2QO1,PDB:2QX1,NCBI_GP:CCP43271.1;Name=CCP43271.1;Note=Rv0533c%2C (MTCY25D10.12c)%2C len: 335 aa. FabH (alternate gene name: mtFabH)%2C 3-oxoacyl-[acyl-carrier protein] synthase III (see citations below)%2C highly similar to others e.g. Q54206|FABH from streptomyces glaucescens (333 aa)%2C FASTA scores: opt: 1109%2C E(): 0%2C (51.4%25 identity in 333 aa overlap)%3B FABH_ECOLI|P24249 3-oxoacyl-[acyl-carrier-protein] synthase III (317 aa)%2CFASTA scores: opt: 666%2C E(): 0%2C (37.1%25 identity in 318 aa overlap)%3B etc. Belongs to the FabH family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fabH;locus_tag=Rv0533c;product=3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III);protein_id=CCP43271.1;transl_table=11
AL123456.3	EMBL	gene	625562	626440	.	-	.	ID=gene-Rv0534c;Name=menA;gbkey=Gene;gene=menA;gene_biotype=protein_coding;locus_tag=Rv0534c
AL123456.3	EMBL	CDS	625562	626440	.	-	0	ID=cds-CCP43272.1;Parent=gene-Rv0534c;Dbxref=EnsemblGenomes-Gn:Rv0534c,EnsemblGenomes-Tr:CCP43272,GOA:P9WIP3,InterPro:IPR000537,InterPro:IPR004657,InterPro:IPR026046,NCBI_GP:CCP43272.1;Name=CCP43272.1;Note=Rv0534c%2C (MTCY25D10.13c)%2C len: 292 aa. Probable menA%2C 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase%2Cintegral membrane protein%2C equivalent to Y13803|MLB1306_2|NP_302556.1 probable 4-dihydroxy-2-naphthoate octaprenyltransferase from Mycobacterium leprae (294 aa)%2C FASTA scores: opt: 1509%2CE(): 0%2C (80.2%25 identity in 288 aa overlap). Also highly similar to others e.g. MENA_ECOLI|P32166|B3930 from Escherichia coli (308 aa)%2C FASTA scores: opt: 495%2C E(): 2.9e-25%2C (36.3 identity in 289 aa overlap)%3B etc. Belongs to the MenA family.;gbkey=CDS;gene=menA;locus_tag=Rv0534c;product=1%2C4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase);protein_id=CCP43272.1;transl_table=11
AL123456.3	EMBL	gene	626457	627251	.	+	.	ID=gene-Rv0535;Name=pnp;gbkey=Gene;gene=pnp;gene_biotype=protein_coding;locus_tag=Rv0535
AL123456.3	EMBL	CDS	626457	627251	.	+	0	ID=cds-CCP43273.1;Parent=gene-Rv0535;Dbxref=EnsemblGenomes-Gn:Rv0535,EnsemblGenomes-Tr:CCP43273,GOA:O06401,InterPro:IPR000845,InterPro:IPR001369,InterPro:IPR010044,NCBI_GP:CCP43273.1;Name=CCP43273.1;Note=Rv0535%2C (MTCY25D10.14c)%2C len: 264 aa. Probable pnp%2C5'-methylthioadenosine phosphorylase%2C highly similar to others e.g. CAB90972.1|AL355832 putative methylthioadenosine phosphorylase from Streptomyces coelicolor (280 aa)%3B etc. Also similar to Rv3307|deoD probable purine nucleoside phosphorylase from Mycobacterium tuberculosis (268 aa). Belongs to the PNP/MTAP family 2 of phosphorylases. Gene name could be inappropriate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pnp;locus_tag=Rv0535;product=Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase);protein_id=CCP43273.1;transl_table=11
AL123456.3	EMBL	gene	627248	628288	.	+	.	ID=gene-Rv0536;Name=galE3;gbkey=Gene;gene=galE3;gene_biotype=protein_coding;gene_synonym=galE2;locus_tag=Rv0536
AL123456.3	EMBL	CDS	627248	628288	.	+	0	ID=cds-CCP43274.1;Parent=gene-Rv0536;Dbxref=EnsemblGenomes-Gn:Rv0536,EnsemblGenomes-Tr:CCP43274,GOA:L7N670,InterPro:IPR001509,InterPro:IPR008089,InterPro:IPR016040,UniProtKB/TrEMBL:L7N670,NCBI_GP:CCP43274.1;Name=CCP43274.1;Note=Rv0536%2C (MTCY25D10.15)%2C len: 346 aa. Possible galE3%2CUDP-glucose 4-epimerase%2C highly similar to CAB76986.1|AL159178 putative epimerase from Streptomyces coelicolor (334 aa)%3B and similar to other epimerases e.g. NP_436775.1|NC_003078 putative NDP-glucose dehydrataseepimerase protein from Sinorhizobium meliloti (368 aa)%3B AF143772|AF143772_7 GepiA from Mycobacterium avium strain 2151 (353 aa)%2C FASTA scores: opt: 577%2C E(): 3.9e-29%2C (36.6%25 identity in 352 aa overlap)%3B GALE_METJA|Q57664 putative UDP-glucose 4-epimerase (305 aa)%2C FASTA scores: opt: 300%2C E(): 1.6e-12%2C (30.9%25 identity in 343 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis proteins e.g. Rv3634c%2C Rv3784%2C etc. Seems to belong to the sugar epimerase family. Note that previously known as galE2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=galE3;locus_tag=Rv0536;product=Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase);protein_id=CCP43274.1;transl_table=11
AL123456.3	EMBL	gene	628298	629731	.	-	.	ID=gene-Rv0537c;Name=Rv0537c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0537c
AL123456.3	EMBL	CDS	628298	629731	.	-	0	ID=cds-CCP43275.1;Parent=gene-Rv0537c;Dbxref=EnsemblGenomes-Gn:Rv0537c,EnsemblGenomes-Tr:CCP43275,UniProtKB/TrEMBL:O06403,NCBI_GP:CCP43275.1;Name=CCP43275.1;Note=Rv0537c%2C (MTCY25D10.16c)%2C len: 477 aa. Probable integral membrane protein%2C showing weak similarity to YDNK_STRCO|P40180 hypothetical 41.2 kDa protein from Streptomyces coelicolor (411 aa)%2C FASTA scores: opt: 122%2CE(): 0.85%2C (28.2%25 identity in 373 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0537c;product=Probable integral membrane protein;protein_id=CCP43275.1;transl_table=11
AL123456.3	EMBL	gene	630040	631686	.	+	.	ID=gene-Rv0538;Name=Rv0538;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0538
AL123456.3	EMBL	CDS	630040	631686	.	+	0	ID=cds-CCP43276.1;Parent=gene-Rv0538;Dbxref=EnsemblGenomes-Gn:Rv0538,EnsemblGenomes-Tr:CCP43276,UniProtKB/TrEMBL:O06404,NCBI_GP:CCP43276.1;Name=CCP43276.1;Note=Rv0538%2C (MTCY25D10.17)%2C len: 548 aa. Possible conserved membrane protein. Middle region highly similar to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein from Mycobacterium bovis (295 aa) possible transmembrane protein with a repetitive proline%2C threonine-rich region at C-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0538;product=Possible conserved membrane protein;protein_id=CCP43276.1;transl_table=11
AL123456.3	EMBL	gene	631743	632375	.	+	.	ID=gene-Rv0539;Name=Rv0539;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0539
AL123456.3	EMBL	CDS	631743	632375	.	+	0	ID=cds-CCP43277.1;Parent=gene-Rv0539;Dbxref=EnsemblGenomes-Gn:Rv0539,EnsemblGenomes-Tr:CCP43277,GOA:P9WMY1,InterPro:IPR001173,InterPro:IPR029044,NCBI_GP:CCP43277.1;Name=CCP43277.1;Note=Rv0539%2C (MTCY25D10.18)%2C len: 210 aa. Probable dolichol-P-sugar synthase%2C highly similar to CAB76989.1|AL159178 putative glycosyltransferase from Streptomyces coelicolor (242 aa)%2C and similar to various dolichol-P-sugar synthetases and sugar transferases e.g. NP_126257.1|NC_000868 dolichyl-phosphate mannose synthase related protein from Pyrococcus abyssi (211 aa)%3B N-terminus of NP_127133.1|NC_000868 dolichol-P-glucose synthetase from Pyrococcus abyssi (378 aa)%3B N-terminus of NP_068880.1|NC_000917 putative dolichol-P-glucose synthetase from Archaeoglobus fulgidus (369 aa)%2C FASTA scores: E(): 2.4e-13%2C (32. 1%25 identity in 193 aa overlap)%3B Q26732 dolichyl-phosphate-mannose synthase precursor from trypanosoma brucei (267 aa)%2C FASTA scores: opt: 179%2C E(): 0.0011%2C (30.7%25 identity in 205 aa overlap)%3B etc. Also similar to Rv2051c|MTY25D10_18 from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0539;product=Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase);protein_id=CCP43277.1;transl_table=11
AL123456.3	EMBL	gene	632372	633034	.	+	.	ID=gene-Rv0540;Name=Rv0540;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0540
AL123456.3	EMBL	CDS	632372	633034	.	+	0	ID=cds-CCP43278.1;Parent=gene-Rv0540;Dbxref=EnsemblGenomes-Gn:Rv0540,EnsemblGenomes-Tr:CCP43278,GOA:O06406,InterPro:IPR018641,InterPro:IPR029044,UniProtKB/TrEMBL:O06406,NCBI_GP:CCP43278.1;Name=CCP43278.1;Note=Rv0540%2C (MTCY25D10.19)%2C len: 220 aa. Conserved hypothetical protein%2C similar to hypothetical proteins from Streptomyces coelicolor: CAB76990.1|AL159178 (213 aa)%3B N-terminus of BAA84086.1|AB032065 (446 aa)%3B and CAB61872.1|AL133252|SCE46_21 (210 aa)%2C FASTA scores: opt: 267%2C E(): 5.3e-10%2C (32.7%25 identity in 202 aa overlap). Also some similarity with D90913_63|PCC6803 from Synecho cystis sp (211 aa)%2C FASTA scores: opt: 189%2C E(): 4.7e-06%2C (25.3 identity in 194 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0540;product=Conserved hypothetical protein;protein_id=CCP43278.1;transl_table=11
AL123456.3	EMBL	gene	633055	634404	.	-	.	ID=gene-Rv0541c;Name=Rv0541c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0541c
AL123456.3	EMBL	CDS	633055	634404	.	-	0	ID=cds-CCP43279.1;Parent=gene-Rv0541c;Dbxref=EnsemblGenomes-Gn:Rv0541c,EnsemblGenomes-Tr:CCP43279,GOA:O06407,UniProtKB/TrEMBL:O06407,NCBI_GP:CCP43279.1;Name=CCP43279.1;Note=Rv0541c%2C (MTCY25D10.20c)%2C len: 449 aa. Probable conserved integral membrane protein%2C highly similar (except first 40 residues) to CAB76994.1|AL159178 putative integral membrane protein from Streptomyces coelicolor (456 aa). Also some similarity to Q13724|GCS1_HUMAN mannosyl-oligosaccharide glucosidase (834 aa)%2C FASTA scores: opt: 150%2C E(): 0.013%2C (27.1%25 identity in 339 aa overlap). Contains PS00041 Bacterial regulatory proteins%2CaraC family signature.;gbkey=CDS;inference=protein motif:PROSITE:PS00041;locus_tag=Rv0541c;product=Probable conserved integral membrane protein;protein_id=CCP43279.1;transl_table=11
AL123456.3	EMBL	gene	634416	635504	.	-	.	ID=gene-Rv0542c;Name=menE;gbkey=Gene;gene=menE;gene_biotype=protein_coding;locus_tag=Rv0542c
AL123456.3	EMBL	CDS	634416	635504	.	-	0	ID=cds-CCP43280.1;Parent=gene-Rv0542c;Dbxref=EnsemblGenomes-Gn:Rv0542c,EnsemblGenomes-Tr:CCP43280,GOA:P9WQ39,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,NCBI_GP:CCP43280.1;Name=CCP43280.1;Note=Rv0542c%2C (MTCY25D10.21c)%2C len: 362 aa. Possible menE%2C O-succinylbenzoic acid-CoA ligase%2C highly similar to Q50170|AAA63145.1|U15187|XCLB 4-Coumarate--CoA ligase from Mycobacterium leprae (352 aa)%2C FASTA scores: opt: 1815%2CE(): 0%2C (78.9%25 identity in 351 aa overlap). Also similar to N-terminus of acid-CoA ligases e.g. NP_471116.1|NC_003212 O-succinylbenzoic acid-CoA ligase from Listeria innocua (469 aa)%3B NP_390957.1|NC_000964 O-succinylbenzoic acid-CoA ligase from Bacillus subtilis (486 aa)%3B MENE_HAEIN|P44565 O-succinylbenzoic acid-CoA ligase from Haemophilus influenzae (452 aa)%2C FASTA scores: opt: 307%2C E(): 4.6e-12%2C(25.4%25 identity in 339 aa overlap)%3B etc. Also some similarity with fadD proteins from Mycobacterium tuberculosis. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;gbkey=CDS;gene=menE;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0542c;product=Possible O-succinylbenzoic acid--CoA ligase MenE (OSB-CoA synthetase) (O-succinylbenzoate-CoA synthase);protein_id=CCP43280.1;transl_table=11
AL123456.3	EMBL	gene	635573	635875	.	-	.	ID=gene-Rv0543c;Name=Rv0543c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0543c
AL123456.3	EMBL	CDS	635573	635875	.	-	0	ID=cds-CCP43281.1;Parent=gene-Rv0543c;Dbxref=EnsemblGenomes-Gn:Rv0543c,EnsemblGenomes-Tr:CCP43281,InterPro:IPR021784,UniProtKB/TrEMBL:O06409,NCBI_GP:CCP43281.1;Name=CCP43281.1;Note=Rv0543c%2C (MTCY25D10.22c)%2C len: 100 aa. Conserved protein%2C equivalent to Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (100 aa)%2CFASTA scores: opt: 493%2C E(): 6.1e-30%2C (73.5%25 identity in 98 aa overlap). Some similarity to Rv3046c|NP_217562.1 from Mycobacterium tuberculosis. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004). Alternative nucleotide at position 635633 (C->T%3B A81A) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0543c;product=Conserved protein;protein_id=CCP43281.1;transl_table=11
AL123456.3	EMBL	gene	635935	636213	.	-	.	ID=gene-Rv0544c;Name=Rv0544c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0544c
AL123456.3	EMBL	CDS	635935	636213	.	-	0	ID=cds-CCP43282.1;Parent=gene-Rv0544c;Dbxref=EnsemblGenomes-Gn:Rv0544c,EnsemblGenomes-Tr:CCP43282,GOA:O06410,UniProtKB/TrEMBL:O06410,NCBI_GP:CCP43282.1;Name=CCP43282.1;Note=Rv0544c%2C (MTCY25D10.23c)%2C len: 92 aa. Possible conserved transmembrane protein%2C equivalent to NP_302470.1|NC_002677 possible membrane protein from Mycobacterium leprae (96 aa)%3B and shows some similarity to MLU15187_33|Q50172|U296V from Mycobacterium leprae (36 aa)%2CFASTA scores: opt: 151%2C E(): 2.1e-05%2C (71.4%25 identity in 35 aa overlap). Also some similarity with VATL_NEPNO|Q26250 vacuolar ATP synthase 16 kDa proteolipid from Nephrops norvegicus (159 aa)%2C FASTA scores: opt: 80%2C E(): 11%2C (26.1%25 identity in 88 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0544c;product=Possible conserved transmembrane protein;protein_id=CCP43282.1;transl_table=11
AL123456.3	EMBL	gene	636210	637463	.	-	.	ID=gene-Rv0545c;Name=pitA;gbkey=Gene;gene=pitA;gene_biotype=protein_coding;locus_tag=Rv0545c
AL123456.3	EMBL	CDS	636210	637463	.	-	0	ID=cds-CCP43283.1;Parent=gene-Rv0545c;Dbxref=EnsemblGenomes-Gn:Rv0545c,EnsemblGenomes-Tr:CCP43283,GOA:P9WIA7,InterPro:IPR001204,NCBI_GP:CCP43283.1;Name=CCP43283.1;Note=Rv0545c%2C (MTCY25D10.24c)%2C len: 417 aa. Probable pitA%2C low-affinity inorganic phosphate transporter%2Cintegral membrane protein%2C equivalent to Q50173|NP_302471.1 pitA from Mycobacterium leprae (414 aa)%2C FASTA scores: opt: 2035%2C E(): 0%2C (76.3%25 identity in 418 aa overlap). Also highly similar to others e.g. CAB59461.1|AL132644 putative low-affinity phosphate transport protein from Streptomyces coelicolor (423 aa)%3B PITA_ECOLI|P37308 low-affinity inorganic phosphate transporter from Escherichia coli (499 aa)%2C FASTA scores: opt: 304%2C E(): 6.9e-10%2C (32.5 %25 identity in 234 aa overlap)%3B etc. Belongs to the PHO-4 family of transporters%2C pit subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pitA;locus_tag=Rv0545c;product=Probable low-affinity inorganic phosphate transporter integral membrane protein PitA;protein_id=CCP43283.1;transl_table=11
AL123456.3	EMBL	gene	637583	637969	.	-	.	ID=gene-Rv0546c;Name=Rv0546c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0546c
AL123456.3	EMBL	CDS	637583	637969	.	-	0	ID=cds-CCP43284.1;Parent=gene-Rv0546c;Dbxref=EnsemblGenomes-Gn:Rv0546c,EnsemblGenomes-Tr:CCP43284,GOA:O06412,InterPro:IPR004360,InterPro:IPR029068,UniProtKB/TrEMBL:O06412,NCBI_GP:CCP43284.1;Name=CCP43284.1;Note=Rv0546c%2C (MTCY25D10.25c)%2C len: 128 aa. Conserved protein%2C equivalent to AAA63111.1|U15187|Q50174|U296X hypothetical protein from Mycobacterium leprae (144 aa)%2CFASTA scores: opt: 748%2C E(): 0%2C (84.2%25 identity in 133 aa overlap). Also highly similar to CAB95979.1|AL360034 conserved hypothetical protein from Streptomyces coelicolor (130 aa)%3B and similar to AE000854_8|O26852 S-D-lactoylglutathione methylglyoxal lyase from Methanobacterium thermoautotropto (116 aa)%2C FASTA scores: opt: 155%2C E(): 0.00019%2C (30.6%25 identity in 108 aa overlap)%3B YAER_ECOLI hypothetical 14.7 kDa protein from Escherichia coli (129 aa)%2C FASTA scores: opt: 104%2C E(): 0.42%2C (28.7%25 identity in 115 aa overlap). Also similar to Rv2068c from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0546c;product=Conserved protein;protein_id=CCP43284.1;transl_table=11
AL123456.3	EMBL	gene	638032	638916	.	-	.	ID=gene-Rv0547c;Name=Rv0547c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0547c
AL123456.3	EMBL	CDS	638032	638916	.	-	0	ID=cds-CCP43285.1;Parent=gene-Rv0547c;Dbxref=EnsemblGenomes-Gn:Rv0547c,EnsemblGenomes-Tr:CCP43285,GOA:O06413,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O06413,NCBI_GP:CCP43285.1;Name=CCP43285.1;Note=Rv0547c%2C (MTCY25D10.26c)%2C len: 294 aa. Possible oxidoreductase%2C similar to various oxidoreductases e.g. fatty acyl-CoA reductase from Acinetobacter calcoaceticus (295 aa)%3B NP_280196.1|NC_002607 3-oxoacyl-[acyl-carrier-protein] reductase from Halobacterium sp. NRC-1 (255 aa)%3B NP_349214.1|NC_003030 Short-chain alcohol dehydrogenase family protein from Clostridium acetobutylicum (255 aa)%3B etc. Also similar to several proteins from Mycobacterium tuberculosis e.g. Y04M_MYCTU|Q10783 putative oxidoreductase (341 aa)%2C FASTA scores: opt: 644%2C E(): 0%2C (46.1%25 identity in 258 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0547c;product=Possible oxidoreductase;protein_id=CCP43285.1;transl_table=11
AL123456.3	EMBL	gene	639012	639956	.	-	.	ID=gene-Rv0548c;Name=menB;gbkey=Gene;gene=menB;gene_biotype=protein_coding;locus_tag=Rv0548c
AL123456.3	EMBL	CDS	639012	639956	.	-	0	ID=cds-CCP43286.1;Parent=gene-Rv0548c;Dbxref=EnsemblGenomes-Gn:Rv0548c,EnsemblGenomes-Tr:CCP43286,GOA:P9WNP5,InterPro:IPR001753,InterPro:IPR010198,InterPro:IPR014748,InterPro:IPR029045,PDB:1Q51,PDB:1Q52,PDB:1RJM,PDB:1RJN,PDB:3T8A,PDB:3T8B,NCBI_GP:CCP43286.1;Name=CCP43286.1;Note=Rv0548c%2C (MTCY25D10.27c)%2C len: 314 aa. menB%2Cnaphthoate synthase (dihydroxynaphthonic acid synthase)%2Cequivalent to NP_302473.1|NC_002677 naphthoate synthase from Mycobacterium leprae (300 aa). Also similar to others e.g. MENB_ECOLI|P27290 naphthoate synthase from Escherichia coli (285 aa)%2C FASTA scores: opt: 599%2C E(): 9.3e-33%2C (48.1 identity in 285 aa overlap)%3B etc. Belongs to the enoyl-CoA hydratase/isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=menB;locus_tag=Rv0548c;product=Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase);protein_id=CCP43286.1;transl_table=11
AL123456.3	EMBL	gene	640228	640641	.	-	.	ID=gene-Rv0549c;Name=vapC3;gbkey=Gene;gene=vapC3;gene_biotype=protein_coding;locus_tag=Rv0549c
AL123456.3	EMBL	CDS	640228	640641	.	-	0	ID=cds-CCP43287.1;Parent=gene-Rv0549c;Dbxref=EnsemblGenomes-Gn:Rv0549c,EnsemblGenomes-Tr:CCP43287,GOA:P9WFB7,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43287.1;Name=CCP43287.1;Note=Rv0549c%2C (MTCY25D10.28c)%2C len: 137 aa. Possible vapC3%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv0550c%2C contains PIN domain (see Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others e.g. Rv0960%2CRv0065%2C and Rv1720c from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC3;locus_tag=Rv0549c;product=Possible toxin VapC3;protein_id=CCP43287.1;transl_table=11
AL123456.3	EMBL	gene	640638	640904	.	-	.	ID=gene-Rv0550c;Name=vapB3;gbkey=Gene;gene=vapB3;gene_biotype=protein_coding;locus_tag=Rv0550c
AL123456.3	EMBL	CDS	640638	640904	.	-	0	ID=cds-CCP43288.1;Parent=gene-Rv0550c;Dbxref=EnsemblGenomes-Gn:Rv0550c,EnsemblGenomes-Tr:CCP43288,GOA:P9WJ59,InterPro:IPR009956,NCBI_GP:CCP43288.1;Name=CCP43288.1;Note=Rv0550c%2C (MTCY25D10.29c)%2C len: 88 aa. Possible vapB3%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv0549c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005).;gbkey=CDS;gene=vapB3;locus_tag=Rv0550c;product=Possible antitoxin VapB3;protein_id=CCP43288.1;transl_table=11
AL123456.3	EMBL	gene	641096	642811	.	-	.	ID=gene-Rv0551c;Name=fadD8;gbkey=Gene;gene=fadD8;gene_biotype=protein_coding;locus_tag=Rv0551c
AL123456.3	EMBL	CDS	641096	642811	.	-	0	ID=cds-CCP43289.1;Parent=gene-Rv0551c;Dbxref=EnsemblGenomes-Gn:Rv0551c,EnsemblGenomes-Tr:CCP43289,GOA:O06417,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O06417,NCBI_GP:CCP43289.1;Name=CCP43289.1;Note=Rv0551c%2C (MTCY25D10.30c)%2C len: 571 aa. Probable fadD8%2C fatty-acid-CoA synthetase%2C similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa)%2C FASTA scores: opt: 585%2C E(): 9.5e-30%2C (28.7%25 identity in 536 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Note other possible start sites exist downstream of this start.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD8;inference=protein motif:PROSITE:PS00455;locus_tag=Rv0551c;product=Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP43289.1;transl_table=11
AL123456.3	EMBL	repeat_region	642754	642811	.	-	.	ID=id-Rv0551c;Note=58 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region;gene=fadD8;locus_tag=Rv0551c
AL123456.3	EMBL	gene	642889	644493	.	+	.	ID=gene-Rv0552;Name=Rv0552;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0552
AL123456.3	EMBL	CDS	642889	644493	.	+	0	ID=cds-CCP43290.1;Parent=gene-Rv0552;Dbxref=EnsemblGenomes-Gn:Rv0552,EnsemblGenomes-Tr:CCP43290,GOA:O06418,InterPro:IPR011059,InterPro:IPR013108,UniProtKB/TrEMBL:O06418,NCBI_GP:CCP43290.1;Name=CCP43290.1;Note=Rv0552%2C (MTCY25D10.31)%2C len: 534 aa. Conserved protein%2C similar to others from several organisms. Also shows some similarity with regulatory proteins e.g. AEPA_ERWCA|Q06555 exoenzymes regulatory protein aepA [Precursor] from Erwinia carotovora (465 aa)%2C FASTA scores: opt: 278%2C E(): 7.6e-11%2C (23.0%25 identity in 408 aa overlap). Also similar to Z99119|BSUB0016_28 from Bacillus subtilis (529 aa)%2C FASTA scores: opt: 436%2C E(): 8.3e-20%2C (23.8%25 identity in 547 aa overlap). C-terminus is similar to MLRRNOPR_1 hypothetical 17.7 kDa protein from Mycobacterium leprae (154 aa)%2C FASTA score: (43.1%25 identity in 160 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0552;product=Conserved protein;protein_id=CCP43290.1;transl_table=11
AL123456.3	EMBL	gene	644490	645470	.	+	.	ID=gene-Rv0553;Name=menC;gbkey=Gene;gene=menC;gene_biotype=protein_coding;locus_tag=Rv0553
AL123456.3	EMBL	CDS	644490	645470	.	+	0	ID=cds-CCP43291.1;Parent=gene-Rv0553;Dbxref=EnsemblGenomes-Gn:Rv0553,EnsemblGenomes-Tr:CCP43291,GOA:P9WJP3,InterPro:IPR001354,InterPro:IPR010196,InterPro:IPR013342,InterPro:IPR029017,InterPro:IPR029065,NCBI_GP:CCP43291.1;Name=CCP43291.1;Note=Rv0553%2C (MTCY25D10.32)%2C len: 326 aa. Probable menC%2Cmuconate cycloisomerase%2C equivalent to NP_302476.1|NC_002677 putative isomerase/racemase from Mycobacterium leprae (334 aa). Also similar to other muconate cycloisomerases e.g. TCBD_PSESP|P27099 chloromuconate cycloisomerase (370 aa)%2C FASTA scores: opt: 249%2C E(): 7.8e-09%2C (32.7%25 identity in 199 aa overlap). Also similar to O-succinylbenzoate-CoA synthases. Belongs to the mandelate racemase / muconate lactonizing enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=menC;locus_tag=Rv0553;product=Probable muconate cycloisomerase MenC (cis%2Ccis-muconate lactonizing enzyme) (MLE);protein_id=CCP43291.1;transl_table=11
AL123456.3	EMBL	gene	645467	646255	.	+	.	ID=gene-Rv0554;Name=bpoC;gbkey=Gene;gene=bpoC;gene_biotype=protein_coding;locus_tag=Rv0554
AL123456.3	EMBL	CDS	645467	646255	.	+	0	ID=cds-CCP43292.1;Parent=gene-Rv0554;Dbxref=EnsemblGenomes-Gn:Rv0554,EnsemblGenomes-Tr:CCP43292,GOA:P9WNH1,InterPro:IPR000073,InterPro:IPR000639,InterPro:IPR029058,PDB:3E3A,PDB:3HSS,PDB:3HYS,PDB:3HZO,NCBI_GP:CCP43292.1;Name=CCP43292.1;Note=Rv0554%2C (MTCY25D10.33)%2C len: 262 aa. Possible bpoC%2Cperoxidase (non-haem peroxidase)%2C equivalent to NP_302477.1|NC_002677 putative hydrolase from Mycobacterium leprae (265 aa). Also highly similar or similar to various hydrolases and peroxidases e.g. CAB38877.1|AL035707|T36181 probable hydrolase from Streptomyces coelicolor (272 aa)%3B CAC48368.1|Y16952 putative hydrolase from Amycolatopsis mediterranei (284 aa)%3B P29715|BPA2_STRAU non-haem bromoperoxidase bpo-a2 (bromide peroxidase) from Streptomyces aureofaciens (277 aa)%2C FASTA scores: opt: 325%2CE(): 2.3e-15%2C (29.5%25 identity in 268 aa overlap)%3B O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase (chloride peroxidase) from Streptomyces aureofaciens (278 aa)%3B etc. Also similar to M. tuberculosis non-heme haloperoxidases and epoxide hydrolases e.g. Rv1938%2C Rv3617%2Cetc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bpoC;locus_tag=Rv0554;product=Possible peroxidase BpoC (non-haem peroxidase);protein_id=CCP43292.1;transl_table=11
AL123456.3	EMBL	gene	646298	647962	.	+	.	ID=gene-Rv0555;Name=menD;gbkey=Gene;gene=menD;gene_biotype=protein_coding;locus_tag=Rv0555
AL123456.3	EMBL	CDS	646298	647962	.	+	0	ID=cds-CCP43293.1;Parent=gene-Rv0555;Dbxref=EnsemblGenomes-Gn:Rv0555,EnsemblGenomes-Tr:CCP43293,GOA:P9WK11,InterPro:IPR004433,InterPro:IPR012001,InterPro:IPR029061,NCBI_GP:CCP43293.1;Name=CCP43293.1;Note=Rv0555%2C (MTCY25D10.34)%2C len: 554 aa. Probable menD%2Cmenaquinone biosynthesis protein%2C including 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase and 2-oxoglutarate decarboxylase activities. Equivalent to NP_302478.1|NC_002677 putative 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase from Mycobacterium leprae (556 aa). Also similar to others e.g. MEND_BACSU|P23970 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase from Bacillus subtilis (548 aa)%2C FASTA scores: opt: 488%2C E(): 2.3e-21%2C (34.3%25 identity in 545 aa overlap)%3B etc. Cofactor: thiamine pyrophosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=menD;locus_tag=Rv0555;product=Probable bifunctional menaquinone biosynthesis protein MenD : 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) + 2-oxoglutarate decarboxylase (alpha-ketoglutarate decarboxylase) (KDC);protein_id=CCP43293.1;transl_table=11
AL123456.3	EMBL	gene	647959	648474	.	+	.	ID=gene-Rv0556;Name=Rv0556;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0556
AL123456.3	EMBL	CDS	647959	648474	.	+	0	ID=cds-CCP43294.1;Parent=gene-Rv0556;Dbxref=EnsemblGenomes-Gn:Rv0556,EnsemblGenomes-Tr:CCP43294,GOA:O06422,UniProtKB/TrEMBL:O06422,NCBI_GP:CCP43294.1;Name=CCP43294.1;Note=Rv0556%2C (MTCY25D10.35)%2C len: 171 aa. Probable conserved transmembrane protein%2C equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0556;product=Probable conserved transmembrane protein;protein_id=CCP43294.1;transl_table=11
AL123456.3	EMBL	gene	648536	649672	.	+	.	ID=gene-Rv0557;Name=mgtA;gbkey=Gene;gene=mgtA;gene_biotype=protein_coding;gene_synonym=mtfB;locus_tag=Rv0557
AL123456.3	EMBL	CDS	648536	649672	.	+	0	ID=cds-CCP43295.1;Parent=gene-Rv0557;Dbxref=EnsemblGenomes-Gn:Rv0557,EnsemblGenomes-Tr:CCP43295,GOA:P9WMY5,InterPro:IPR001296,InterPro:IPR028098,NCBI_GP:CCP43295.1;Name=CCP43295.1;Note=Rv0557%2C (MTCY25D10.36)%2C len: 378 aa. MgtA (previously known as pimB)%2C mannosyltransferase (see citation below)%2C similar to other various transferases e.g. NP_243554.1|NC_002570 alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans (381 aa)%3B NP_249533.1|NC_002516 probable glycosyl transferase from Pseudomonas aeruginosa (406 aa)%3B NP_419573.1|NC_002696 glycosyl transferase%2C group 1 family protein%2C from Caulobacter crescentus (455 aa)%3B etc. Also similar to Q55598 hypothetical 44.9 kDa protein from synechocystis SP (409 aa)%2C FASTA scores: opt: 703%2C E(): 0%2C (33.9%25 identity in 378 aa overlap)%3B GPI3_YEAST|P32363 n-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (452 aa)%2C FASTA scores: opt: 230%2C E(): 1.1e-07%2C(23.5%25 identity in 328 aa overlap).;gbkey=CDS;gene=mgtA;locus_tag=Rv0557;product=Mannosyltransferase MgtA;protein_id=CCP43295.1;transl_table=11
AL123456.3	EMBL	gene	649689	650393	.	+	.	ID=gene-Rv0558;Name=menH;gbkey=Gene;gene=menH;gene_biotype=protein_coding;gene_synonym=menG,ubiE;locus_tag=Rv0558
AL123456.3	EMBL	CDS	649689	650393	.	+	0	ID=cds-CCP43296.1;Parent=gene-Rv0558;Dbxref=EnsemblGenomes-Gn:Rv0558,EnsemblGenomes-Tr:CCP43296,GOA:P9WFR3,InterPro:IPR004033,InterPro:IPR023576,InterPro:IPR029063,NCBI_GP:CCP43296.1;Name=CCP43296.1;Note=Rv0558%2C (MTCY25D10.37)%2C len: 234 aa. Probable menH (alternate gene name: menG)%2C ubiquinone/menaquinone biosynthesis methlytransferase (2-heptaprenyl-1%2C4-naphthoquinone methyltransferase)%2Cequivalent to NP_302480.1|NC_002677 putative ubiquinone/menaquinone biosynthesis methyltransferase from Mycobacterium leprae (238 aa). Also highly similar to others e.g. CAB44537.1|AL078618|T34630 from Streptomyces coelicolor (231 aa)%3B UBIE_ECOLI|P27851 from Escherichia coli strain K12 (251 aa)%2C FASTA scores: opt: 421%2C E(): 1.2e-21%2C (43.2%25 identity in 227 aa overlap)%3B GRC2_BACSU|P31113 from Bacillus subtilis (233 aa)%2C FASTA scores: opt: 345%2C E(): 1.4e-16%2C (34.6%25 identity in 231 aa overlap)%3B etc. Belongs to the UbiE family. Note that previously known as ubiE.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=menH;locus_tag=Rv0558;product=Probable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1%2C4-naphthoquinone methyltransferase);protein_id=CCP43296.1;transl_table=11
AL123456.3	EMBL	gene	650407	650745	.	-	.	ID=gene-Rv0559c;Name=Rv0559c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0559c
AL123456.3	EMBL	CDS	650407	650745	.	-	0	ID=cds-CCP43297.1;Parent=gene-Rv0559c;Dbxref=EnsemblGenomes-Gn:Rv0559c,EnsemblGenomes-Tr:CCP43297,GOA:P9WKL3,InterPro:IPR007969,NCBI_GP:CCP43297.1;Name=CCP43297.1;Note=Rv0559c%2C (MTCY25D10.38c)%2C len: 112 aa. Possible conserved secreted protein%2C similar to NP_302481.1|NC_002677 putative secreted protein from Mycobacterium leprae (112 aa). Also similar to Y08B_MYCTU|Q11048 hypothetical 11.6 kDa protein FASTA scores: opt: 111%2C E(): 011%2C (25.4%25 identity in 114 aa overlap). Contains possible N-terminal signal sequence. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0559c;product=Possible conserved secreted protein;protein_id=CCP43297.1;transl_table=11
AL123456.3	EMBL	gene	650779	651504	.	-	.	ID=gene-Rv0560c;Name=Rv0560c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0560c
AL123456.3	EMBL	CDS	650779	651504	.	-	0	ID=cds-CCP43298.1;Parent=gene-Rv0560c;Dbxref=EnsemblGenomes-Gn:Rv0560c,EnsemblGenomes-Tr:CCP43298,GOA:P9WKL5,InterPro:IPR025714,InterPro:IPR029063,NCBI_GP:CCP43298.1;Name=CCP43298.1;Note=Rv0560c%2C (MTCY25D10.39c)%2C len: 241 aa. Possible benzoquinone methyltransferase (see citation below)%2Csimilar to other hypothetical proteins and methyltransferases e.g. Q54300 methyltransferase (211 aa)%2CFASTA scores: opt: 203%2C E(): 4.8e-07%2C (30.9%25 identity in 136 aa overlap). Similar to Rv3699%2C Rv1377c%2C Rv2675c%2C etc from Mycobacterium tuberculosis. Rv0560c can be induced by salicylate and para-amino-salicylate (pas).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0560c;product=Possible benzoquinone methyltransferase (methylase);protein_id=CCP43298.1;transl_table=11
AL123456.3	EMBL	gene	651529	652755	.	-	.	ID=gene-Rv0561c;Name=Rv0561c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0561c
AL123456.3	EMBL	CDS	651529	652755	.	-	0	ID=cds-CCP43299.1;Parent=gene-Rv0561c;Dbxref=EnsemblGenomes-Gn:Rv0561c,EnsemblGenomes-Tr:CCP43299,GOA:P9WNY9,InterPro:IPR002938,InterPro:IPR003042,InterPro:IPR011777,NCBI_GP:CCP43299.1;Name=CCP43299.1;Note=Rv0561c%2C (MTCY25D10.40c)%2C len: 408 aa. Possible oxidoreductase%2C highly similar (except in first 30 aa) to NP_302482.1|NC_002677 putative FAD-linked oxidoreductase from Mycobacterium leprae (408 aa). Also similar to T34627 probable electron transfer oxidoreductase from Streptomyces coelicolor (430 aa)%3B and some bacteriochlorophyll synthases e.g. NP_069300.1|NC_000917 bacteriochlorophyll synthase from Archaeoglobus fulgidus (410 aa)%3B Q55087 geranylgeranyl hydrogenase (407 aa)%2C FASTA scores: opt: 208%2C E(): 1.7e-06%2C(26.9%25 identity in 327 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0561c;product=Possible oxidoreductase;protein_id=CCP43299.1;transl_table=11
AL123456.3	EMBL	gene	652771	653778	.	+	.	ID=gene-Rv0562;Name=grcC1;gbkey=Gene;gene=grcC1;gene_biotype=protein_coding;locus_tag=Rv0562
AL123456.3	EMBL	CDS	652771	653778	.	+	0	ID=cds-CCP43300.1;Parent=gene-Rv0562;Dbxref=EnsemblGenomes-Gn:Rv0562,EnsemblGenomes-Tr:CCP43300,GOA:O06428,InterPro:IPR000092,InterPro:IPR008949,InterPro:IPR017446,UniProtKB/TrEMBL:O06428,NCBI_GP:CCP43300.1;Name=CCP43300.1;Note=Rv0562%2C (MTCY25D10.41)%2C len: 335 aa. Probable grcC1%2Cpolyprenyl diphosphate synthetase%2C equivalent to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl) e.g. GRC3_BACSU|P31114 probable heptaprenyl diphosphate syntetase (348 aa)%2C FASTA scores: opt: 599%2C E(): 4e-31%2C(33.2%25 identity in 307 aa overlap)%3B etc. Also highly similar to Mycobacterium tuberculosis proteins Rv0989c|grcC2|NP_215504.1|MTCI237.03c probable polyprenyl-diphosphate synthase (325 aa)%3B Rv3383c%2C Rv3398c%2Cetc. Contains PS00444 Polyprenyl synthetases signature 2. Belongs to the FPP/GGPP synthetases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=grcC1;inference=protein motif:PROSITE:PS00444;locus_tag=Rv0562;product=Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase);protein_id=CCP43300.1;transl_table=11
AL123456.3	EMBL	gene	653879	654739	.	+	.	ID=gene-Rv0563;Name=htpX;gbkey=Gene;gene=htpX;gene_biotype=protein_coding;locus_tag=Rv0563
AL123456.3	EMBL	CDS	653879	654739	.	+	0	ID=cds-CCP43301.1;Parent=gene-Rv0563;Dbxref=EnsemblGenomes-Gn:Rv0563,EnsemblGenomes-Tr:CCP43301,GOA:P9WHS5,InterPro:IPR001915,InterPro:IPR022919,NCBI_GP:CCP43301.1;Name=CCP43301.1;Note=Rv0563%2C (MTV039.01%2C MTCY25D10.42)%2C len: 286 aa. (alternative start at position 654006). Probable htpX%2Cprotease heat shock protein X (transmembrane protein)%2Cequivalent to NP_302484.1|NC_002677 putative peptidase from Mycobacterium leprae (287 aa). Also highly similar to others e.g. CAC08262.1|AL392146 putative peptidase from Streptomyces coelicolor (287 aa)%3B NP_387431.1|NC_003047 putative protease transmembrane protein from Sinorhizobium meliloti (319 aa)%3B NP_105051.1|NC_002678 heat shock protein (htpX) from Mesorhizobium loti (336 aa)%3B NP_248692.1|NC_000909|U67608|MJU67608_8 heat shock protein HtpX%2C possibly protease (htpX) from Methanococcus jannaschii (284 aa)%2C FASTA scores: opt: 660%2C E(): 0%2C (46.5 identity in 245 aa overlap). Continuation of MTCY25D10.42. Belongs to peptidase family M48 (zinc metalloprotease). Cofactor: Zinc. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=htpX;inference=protein motif:PROSITE:PS00142;locus_tag=Rv0563;product=Probable protease transmembrane protein heat shock protein HtpX;protein_id=CCP43301.1;transl_table=11
AL123456.3	EMBL	gene	654924	655949	.	-	.	ID=gene-Rv0564c;Name=gpdA1;gbkey=Gene;gene=gpdA1;gene_biotype=protein_coding;gene_synonym=glyC,gpsA;locus_tag=Rv0564c
AL123456.3	EMBL	CDS	654924	655949	.	-	0	ID=cds-CCP43302.1;Parent=gene-Rv0564c;Dbxref=EnsemblGenomes-Gn:Rv0564c,EnsemblGenomes-Tr:CCP43302,GOA:P9WN75,InterPro:IPR006109,InterPro:IPR006168,InterPro:IPR008927,InterPro:IPR011128,InterPro:IPR013328,InterPro:IPR016040,NCBI_GP:CCP43302.1;Name=CCP43302.1;Note=Rv0564c%2C (MTV039.02c)%2C len: 341 aa. Possible gpdA1(alternate gene names: gpsA%2C glyC)%2Cglycerol-3-phosphate dehydrogenase [NAD(P)+] dependent%2Csimilar to many other glycerol-3-phosphate dehydrogenases e.g. P46919|GPDA_BACSU from Bacillus subtilis (345 aa)%2CFASTA scores: opt: 731%2C E(): 0%2C (37.3%25 identity in 332 aa overlap)%3B etc. Also similar to Rv2982c|gpdA2|MTCY349.05|Z83018|MTCY349_5 from Mycobacterium tuberculosis (334 aa)%2C FASTA scores: opt: 740%2C E(): 0%2C (40.4%25 identity in 322 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gpdA1;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0564c;product=Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase);protein_id=CCP43302.1;transl_table=11
AL123456.3	EMBL	gene	656010	657470	.	-	.	ID=gene-Rv0565c;Name=Rv0565c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0565c
AL123456.3	EMBL	CDS	656010	657470	.	-	0	ID=cds-CCP43303.1;Parent=gene-Rv0565c;Dbxref=EnsemblGenomes-Gn:Rv0565c,EnsemblGenomes-Tr:CCP43303,GOA:O53762,UniProtKB/TrEMBL:O53762,NCBI_GP:CCP43303.1;Name=CCP43303.1;Note=Rv0565c%2C (MTV039.03c)%2C len: 486 aa. Probable monoxygenase%2C highly similar to NP_301173.1|NC_002677 putative monooxygenase from Mycobacterium leprae (494 aa). Also highly similar to others e.g. NP_421371.1|NC_002696 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa)%3B C-terminus of NP_051574.1|NC_000958 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa)%3B P12015|CYMO_ACISP cyclohexanone monooxygenase from Acinetobacter sp. (542 aa)%2C FASTA scores: opt: 354%2C E(): 2.1e-16%2C (23.7%25 identity in 435 aa overlap)%3B etc. Also similar to other putative monoxygenases from Mycobacterium tuberculosis e.g. Rv3854c (489 aa)%2C MTCY01A6.14 (489 aa)%2CMTV013_4 (495 aa)%2C MTCY31.20 (495 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0565c;product=Probable monooxygenase;protein_id=CCP43303.1;transl_table=11
AL123456.3	EMBL	gene	657548	658039	.	-	.	ID=gene-Rv0566c;Name=Rv0566c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0566c
AL123456.3	EMBL	CDS	657548	658039	.	-	0	ID=cds-CCP43304.1;Parent=gene-Rv0566c;Dbxref=EnsemblGenomes-Gn:Rv0566c,EnsemblGenomes-Tr:CCP43304,GOA:P9WFK9,InterPro:IPR007551,NCBI_GP:CCP43304.1;Name=CCP43304.1;Note=Rv0566c%2C (MTV039.04c)%2C len: 163 aa. Conserved protein%2C similar to others e.g. P77482|YAJQ_ECOLI hypothetical 19.0 KDa protein from Escherichia coli (169 aa)%2C FASTA scores: opt: 422%2C E(): 5.4e-20%2C (44.1 identity in 161 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0566c;product=Conserved protein;protein_id=CCP43304.1;transl_table=11
AL123456.3	EMBL	gene	658109	658189	.	+	.	ID=gene-tyrT;Name=tyrT;gbkey=Gene;gene=tyrT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	658109	658189	.	+	.	ID=rna-tyrT;Parent=gene-tyrT;Note=codon recognized: UAC%3B tyrT%2C tRNA-Tyr%2C anticodon gta%2C length %3D 81;anticodon=(pos:658143..658145);gbkey=tRNA;gene=tyrT;product=tRNA-Tyr
AL123456.3	EMBL	exon	658109	658189	.	+	.	ID=exon-tyrT-1;Parent=rna-tyrT;Note=codon recognized: UAC%3B tyrT%2C tRNA-Tyr%2C anticodon gta%2C length %3D 81;anticodon=(pos:658143..658145);gbkey=tRNA;gene=tyrT;product=tRNA-Tyr
AL123456.3	EMBL	gene	658321	659340	.	+	.	ID=gene-Rv0567;Name=Rv0567;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0567
AL123456.3	EMBL	CDS	658321	659340	.	+	0	ID=cds-CCP43305.1;Parent=gene-Rv0567;Dbxref=EnsemblGenomes-Gn:Rv0567,EnsemblGenomes-Tr:CCP43305,GOA:O53764,InterPro:IPR001077,InterPro:IPR011991,InterPro:IPR016461,InterPro:IPR029063,UniProtKB/TrEMBL:O53764,NCBI_GP:CCP43305.1;Name=CCP43305.1;Note=Rv0567%2C (MTV039.05)%2C len: 339 aa. Probable methyltransferase%2C similar to several e.g. P39896|TCMO_STRGA tetracenomycin polyketide synthesis 8-O-methyltransferase from Streptomyces glaucescens (339 aa)%2C FASTA scores: opt: 685%2C E(): 0%2C (35.8%25 identity in 335 aa overlap)%3B P10950|HIOM_BOVIN hydroxyindole O-methyltransferase from Bos taurus (345 aa)%2C FASTA scores: opt: 509%2C E(): 3.4e-27%2C (30.7%25 identity in 332 aa overlap) etc.;gbkey=CDS;locus_tag=Rv0567;product=Probable methyltransferase/methylase;protein_id=CCP43305.1;transl_table=11
AL123456.3	EMBL	gene	659450	660868	.	+	.	ID=gene-Rv0568;Name=cyp135B1;gbkey=Gene;gene=cyp135B1;gene_biotype=protein_coding;locus_tag=Rv0568
AL123456.3	EMBL	CDS	659450	660868	.	+	0	ID=cds-CCP43306.1;Parent=gene-Rv0568;Dbxref=EnsemblGenomes-Gn:Rv0568,EnsemblGenomes-Tr:CCP43306,GOA:P9WPM9,InterPro:IPR001128,InterPro:IPR002401,InterPro:IPR017972,NCBI_GP:CCP43306.1;Name=CCP43306.1;Note=Rv0568%2C (MT0594%2C MTV039.06)%2C len: 472 aa. Possible cyp135B1%2C cytochrome P450%2C similar to putative cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. P29980|CPXN_ANASP probable cytochrome P450 from Anabaena sp. strain PCC 7120 (459 aa)%2C FASTA scores: opt: 525%2C E(): 7.2e-27%2C (31.9%25 identity in 417 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0327c|NP_214841.1|NC_000962|CYP135A1|MT0342|MTCY63.32c putative cytochrome P450 (449 aa)%2C FASTA scores: opt: 1080%2CE(): 0%2C (40.5%25 identity in 444 aa overlap)%3B Rv3685c|NP_218202.1|NC_000962 putative cytochrome P450 (476 aa)%3B Rv0136|NP_214650.1|NC_000962 putative cytochrome P450 (441 aa)%3B etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp135B1;inference=protein motif:PROSITE:PS00086;locus_tag=Rv0568;product=Possible cytochrome P450 135B1 Cyp135B1;protein_id=CCP43306.1;transl_table=11
AL123456.3	EMBL	gene	661003	661269	.	+	.	ID=gene-Rv0569;Name=Rv0569;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0569
AL123456.3	EMBL	CDS	661003	661269	.	+	0	ID=cds-CCP43307.1;Parent=gene-Rv0569;Dbxref=EnsemblGenomes-Gn:Rv0569,EnsemblGenomes-Tr:CCP43307,GOA:P9WM83,InterPro:IPR011067,InterPro:IPR015035,NCBI_GP:CCP43307.1;Name=CCP43307.1;Note=Rv0569%2C (MTV039.07)%2C len: 88 aa. Conserved protein. C-terminus highly similar to AAA63065.1|U15184|MLU15184_10 hypothetical protein from Mycobacterium leprae (53 aa)%2CFASTA scores: opt: 140%2C E(): 0.0046%2C (64.7%25 identity in 34 aa overlap). Also similar to T36824|SCI35.11 hypothetical protein from Streptomyces coelicolor (64 aa)%3B and N-terminus of T36956 probable DNA-binding protein from Streptomyces coelicolor (323 aa). Also highly similar to Rv2302|MTCY339.07c|NP_216818.1|NC_000962 conserved hypothetical protein from Mycobacterium tuberculosis (80 aa)%2C FASTA scores: opt: 300%2C E(): 1.4e-13%2C (61.8%25 identity in 76 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0569;product=Conserved protein;protein_id=CCP43307.1;transl_table=11
AL123456.3	EMBL	gene	661295	663373	.	+	.	ID=gene-Rv0570;Name=nrdZ;gbkey=Gene;gene=nrdZ;gene_biotype=protein_coding;locus_tag=Rv0570
AL123456.3	EMBL	CDS	661295	663373	.	+	0	ID=cds-CCP43308.1;Parent=gene-Rv0570;Dbxref=EnsemblGenomes-Gn:Rv0570,EnsemblGenomes-Tr:CCP43308,GOA:P9WH77,InterPro:IPR000788,InterPro:IPR005144,InterPro:IPR008926,InterPro:IPR013344,InterPro:IPR013509,NCBI_GP:CCP43308.1;Name=CCP43308.1;Note=Rv0570%2C (MTV039.08)%2C len: 692 aa. Probable nrdZ%2Cribonucleoside-diphosphate reductase%2C large subunit%2C highly similar to others e.g. NP_070492.1|NC_000917|NRD|AE000988_11 ribonucleotide reductase from Archaeoglobus fulgidus (752 aa)%2C FASTA scores: opt: 2001%2C E(): 0%2C (52.5%25 identity in 562 aa overlap) (N-terminus shorter)%3B U73619|TAU73619_1|T37459 ribonucleotide reductase from Thermoplasma acidophilum (857 aa)%2C FASTA scores: opt: 1678%2C E(): 0%2C (43.7%25 identity in 723 aa overlap)%3B etc. Belongs to the ribonucleoside diphosphate reductase large chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrdZ;locus_tag=Rv0570;product=Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase);protein_id=CCP43308.1;transl_table=11
AL123456.3	EMBL	gene	663487	664818	.	-	.	ID=gene-Rv0571c;Name=Rv0571c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0571c
AL123456.3	EMBL	CDS	663487	664818	.	-	0	ID=cds-CCP43309.1;Parent=gene-Rv0571c;Dbxref=EnsemblGenomes-Gn:Rv0571c,EnsemblGenomes-Tr:CCP43309,GOA:P9WHK1,InterPro:IPR000836,InterPro:IPR029057,InterPro:IPR029058,InterPro:IPR029059,NCBI_GP:CCP43309.1;Name=CCP43309.1;Note=Rv0571c%2C (MTV039.09c)%2C len: 443 aa. Conserved protein%2C highly similar to the products of two adjacent orfs in Mycobacterium leprae: AAA63059.1|U15184|U650S|Q50111 hypothetical protein (258 aa)%2C FASTA scores: opt: 1071%2C E(): 0%2C (72.5%25 identity in 233 aa overlap)%3B and AAA63058.1|U15184|U650T hypothetical protein (86 aa)%2C FASTA scores: opt: 192%2C E(): 6.4e-06%2C(70.8%25 identity in 48 aa overlap). Also similar to others e.g. NP_107072.1|NC_002678 hypothetical protein from Mesorhizobium loti (235 aa)%3B NP_213031.1|NC_000918 hypothetical protein from Aquifex aeolicus (175 aa)%3B etc. And similar to part of hypothetical proteins from Mycobacterium tuberculosis e.g. C-terminus of Rv2143|MTCY270.25c|Z95388|NP_216659.1|NC_000962 (352 aa)%2CFASTA scores: opt: 592%2C E(): 7e-32%2C (49.3%25 identity in 205 aa overlap)%3B N-terminus of Rv2030c|NP_216546.1|NC_000962 (681 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0571c;product=Conserved protein;protein_id=CCP43309.1;transl_table=11
AL123456.3	EMBL	gene	665042	665383	.	-	.	ID=gene-Rv0572c;Name=Rv0572c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0572c
AL123456.3	EMBL	CDS	665042	665383	.	-	0	ID=cds-CCP43310.1;Parent=gene-Rv0572c;Dbxref=EnsemblGenomes-Gn:Rv0572c,EnsemblGenomes-Tr:CCP43310,NCBI_GP:CCP43310.1;Name=CCP43310.1;Note=Rv0572c%2C (MTV039.10c)%2C len: 113 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0572c;product=Hypothetical protein;protein_id=CCP43310.1;transl_table=11
AL123456.3	EMBL	gene	665851	667242	.	-	.	ID=gene-Rv0573c;Name=pncB2;gbkey=Gene;gene=pncB2;gene_biotype=protein_coding;locus_tag=Rv0573c
AL123456.3	EMBL	CDS	665851	667242	.	-	0	ID=cds-CCP43311.1;Parent=gene-Rv0573c;Dbxref=EnsemblGenomes-Gn:Rv0573c,EnsemblGenomes-Tr:CCP43311,GOA:P9WJI7,InterPro:IPR002638,InterPro:IPR006405,InterPro:IPR007229,NCBI_GP:CCP43311.1;Name=CCP43311.1;Note=Rv0573c%2C (MTV039.11c)%2C len: 463 aa. PncB2%2C nicotinic acid phosphoribosyltransferase (See Boshoff et al.%2C 2008). Similar to e.g. NP_213718.1|NC_000918 hypothetical protein from Aquifex aeolicus (426 aa)%3B AL109962|T36953|SCJ1.20 conserved hypothetical protein from Streptomyces coelicolor (438 aa)%2C FASTA scores: opt: 1089%2C E(): 0%2C (49.4%25 identity in 385 aa overlap)%3B P_391053.1|Z99120|BSUB0017_57|NC_000964 protein similar to nicotinate phosphoribosyltransferase from Bacillus subtilis (490 aa)%2C FASTA scores: opt: 955%2CE():0%2C (43.5%25 identity in 356 aa overlap)%3B etc. Also similar to Q10641|Y03F_MYCTU|MTCY130.15c|Rv1330c conserved hypothetical protein from Mycobacterium tuberculosis (509 aa)%2C FASTA scores: opt: 761%2C E(): 0%2C (38.4%25 identity in 437 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pncB2;locus_tag=Rv0573c;product=Nicotinic acid phosphoribosyltransferase PncB2;protein_id=CCP43311.1;transl_table=11
AL123456.3	EMBL	gene	667252	668394	.	-	.	ID=gene-Rv0574c;Name=Rv0574c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0574c
AL123456.3	EMBL	CDS	667252	668394	.	-	0	ID=cds-CCP43312.1;Parent=gene-Rv0574c;Dbxref=EnsemblGenomes-Gn:Rv0574c,EnsemblGenomes-Tr:CCP43312,InterPro:IPR019079,InterPro:IPR029052,NCBI_GP:CCP43312.1;Name=CCP43312.1;Note=Rv0574c%2C (MTV039.12c)%2C len: 380 aa. Conserved hypothetical protein%2C showing similarity with other hypothetical proteins and polyglutamate synthases (encapsulation proteins) e.g. AAK64444.1|AF377339_5|AF377339 polyglutamate synthase CapA from Myxococcus xanthus (405 aa)%3B M24150|BACCAPABC_3|CapA polyglutamate synthase (encapsulation protein) from B.anthracis (411 aa)%2C FASTA scores: opt: 261%2C E(): 4.3e-10%2C(25.8%25 identity in 287 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0574c;product=Conserved hypothetical protein;protein_id=CCP43312.1;transl_table=11
AL123456.3	EMBL	gene	668579	669745	.	-	.	ID=gene-Rv0575c;Name=Rv0575c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0575c
AL123456.3	EMBL	CDS	668579	669745	.	-	0	ID=cds-CCP43313.1;Parent=gene-Rv0575c;Dbxref=EnsemblGenomes-Gn:Rv0575c,EnsemblGenomes-Tr:CCP43313,GOA:O53772,InterPro:IPR002938,InterPro:IPR003042,UniProtKB/TrEMBL:O53772,NCBI_GP:CCP43313.1;Name=CCP43313.1;Note=Rv0575c%2C (MTV039.13c)%2C len: 388 aa. Possible oxidoreductase%2C similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coelicolor (407 aa)%2C FASTA scores: opt: 786%2C E(): 0%2C (38.7%25 identity in 398 aa overlap)%3B P96555|AB000564 salicylate hydroxylase from sphingomonas (395 aa)%2C FASTA scores: opt: 267%2C E():5e-11%2C(26.4%25 identity in 390 aa overlap). Also similar to Rv1260|Z77137|MTCY50.22C from Mycobacterium tuberculosis (372 aa)%2C FASTA scores: opt: 762%2C E(): 0%2C (40.9%25 identity in 345 aa overlap). The transcription of this CDS seems to be activated in macrophages (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0575c;product=Possible oxidoreductase;protein_id=CCP43313.1;transl_table=11
AL123456.3	EMBL	gene	669848	671152	.	+	.	ID=gene-Rv0576;Name=Rv0576;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0576
AL123456.3	EMBL	CDS	669848	671152	.	+	0	ID=cds-CCP43314.1;Parent=gene-Rv0576;Dbxref=EnsemblGenomes-Gn:Rv0576,EnsemblGenomes-Tr:CCP43314,GOA:O53773,InterPro:IPR001845,InterPro:IPR011991,InterPro:IPR013538,InterPro:IPR017517,InterPro:IPR017520,InterPro:IPR023393,UniProtKB/TrEMBL:O53773,NCBI_GP:CCP43314.1;Name=CCP43314.1;Note=Rv0576%2C (MTV039.14)%2C len: 434 aa. Probable transcriptional regulator%2C ArsR family. N-terminus highly similar to others e.g. NP_102487.1|NC_002678 transcriptional regulator from Mesorhizobium loti (104 aa)%3B NP_242952.1|NC_002570 transcriptional regulator (ArsR family) from Bacillus halodurans (109 aa)%3B etc. C-terminal region (~~240-434) shows similarity with D67028_1 from Rhodococcus rhodochrous (112 aa)%3B and Rv0738 from Mycobacterium tuberculosis (182 aa). N-terminus also highly similar to Rv2034 from Mycobacterium tuberculosis (107 aa). Contains helix-turn-helix motif at aa 23-43 (Score 1628%2C+4.73 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0576;product=Probable transcriptional regulatory protein (possibly ArsR-family);protein_id=CCP43314.1;transl_table=11
AL123456.3	EMBL	gene	671166	671951	.	+	.	ID=gene-Rv0577;Name=TB27.3;gbkey=Gene;gene=TB27.3;gene_biotype=protein_coding;gene_synonym=cfp32;locus_tag=Rv0577
AL123456.3	EMBL	CDS	671166	671951	.	+	0	ID=cds-CCP43315.1;Parent=gene-Rv0577;Dbxref=EnsemblGenomes-Gn:Rv0577,EnsemblGenomes-Tr:CCP43315,GOA:P9WIR3,InterPro:IPR004360,InterPro:IPR025870,InterPro:IPR029068,PDB:3OXH,NCBI_GP:CCP43315.1;Name=CCP43315.1;Note=Rv0577%2C (MTV039.15)%2C len: 261 aa. TB27.3%2C conserved protein. Corresponds to O53774|CF30_MYCTU 27 kDa antigen CFP30B from Mycobacterium tuberculosis culture filtrate (260 aa)%2C FASTA scores: opt: 1781%2C E(): 0%2C (100.0%25 identity in 260 aa overlap). Also similar to several hypothetical proteins and hydroxylases from Steptomyces sp. e.g. T35032 probable hydroxylase from Streptomyces coelicolor (263 aa)%3B Q55078 orfA gene product from Streptomyces sp. (275 aa)%2CFASTA scores: E(): 1.5e-1 9%2C (38.6%25 identity in 264 aa overlap)%3B D89734_1|P95754 DNA for SgaA SGAA protein from Streptomyces griseus%3B and SC9B10_20 from Streptomyces coelicolor (267 aa)%2C FASTA score: (38.9 identity in 252 aa overlap). Also similar to Rv0911|MTCY21C12.05 from Mycobacterium tuberculosis (257 aa)%2C FASTA scores: E(): 1.1e-20%2C (32.0%25 identity in 259 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB27.3;locus_tag=Rv0577;product=Conserved protein TB27.3;protein_id=CCP43315.1;transl_table=11
AL123456.3	EMBL	gene	671996	675916	.	-	.	ID=gene-Rv0578c;Name=PE_PGRS7;gbkey=Gene;gene=PE_PGRS7;gene_biotype=protein_coding;locus_tag=Rv0578c
AL123456.3	EMBL	CDS	671996	675916	.	-	0	ID=cds-CCP43316.1;Parent=gene-Rv0578c;Dbxref=EnsemblGenomes-Gn:Rv0578c,EnsemblGenomes-Tr:CCP43316,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MX28,NCBI_GP:CCP43316.1;Name=CCP43316.1;Note=Rv0578c%2C (MTV039.16c)%2C len: 1306 aa. PE_PGRS7%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to many other PGRS proteins e.g. MTCY493.04|Z95844 from Mycobacterium tuberculosis (1329 aa)%2C FASTA scores: opt: 3994%2C E(): 0%2C (54.6%25 identity in 1375 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures possibly fortuitously.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS7;inference=protein motif:PROSITE:PS00583;locus_tag=Rv0578c;product=PE-PGRS family protein PE_PGRS7;protein_id=CCP43316.1;transl_table=11
AL123456.3	EMBL	gene	676238	676996	.	+	.	ID=gene-Rv0579;Name=Rv0579;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0579
AL123456.3	EMBL	CDS	676238	676996	.	+	0	ID=cds-CCP43317.1;Parent=gene-Rv0579;Dbxref=EnsemblGenomes-Gn:Rv0579,EnsemblGenomes-Tr:CCP43317,InterPro:IPR002782,InterPro:IPR012675,InterPro:IPR027798,UniProtKB/TrEMBL:O53776,NCBI_GP:CCP43317.1;Name=CCP43317.1;Note=Rv0579%2C (MTV039.17)%2C len: 252 aa. Conserved hypothetical protein%2C showing some similarity to others e.g. AE001747_4 hypothetical protein from Thermotoga maritima (247 aa)%2C FASTA scores: opt: 612%2C E(): 0%2C (39.6%25 identity in 235 aa overlap)%3B AE001004_2 hypothetical protein from Archaeoglobus fulgidus (159 aa)%2C FASTA scores: opt: 196%2C E(): 1e-06%2C (28.3%25 identity in 159 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0579;product=Conserved hypothetical protein;protein_id=CCP43317.1;transl_table=11
AL123456.3	EMBL	gene	677125	677616	.	-	.	ID=gene-Rv0580c;Name=Rv0580c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0580c
AL123456.3	EMBL	CDS	677125	677616	.	-	0	ID=cds-CCP43318.1;Parent=gene-Rv0580c;Dbxref=EnsemblGenomes-Gn:Rv0580c,EnsemblGenomes-Tr:CCP43318,GOA:O53777,InterPro:IPR016791,UniProtKB/TrEMBL:O53777,NCBI_GP:CCP43318.1;Name=CCP43318.1;Note=Rv0580c%2C (MTV039.18c)%2C len: 163 aa. Conserved protein%2C equivalent to AAA90989.1|U20446|MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0580c;product=Conserved protein;protein_id=CCP43318.1;transl_table=11
AL123456.3	EMBL	gene	677710	677925	.	+	.	ID=gene-Rv0581;Name=vapB26;gbkey=Gene;gene=vapB26;gene_biotype=protein_coding;locus_tag=Rv0581
AL123456.3	EMBL	CDS	677710	677925	.	+	0	ID=cds-CCP43319.1;Parent=gene-Rv0581;Dbxref=EnsemblGenomes-Gn:Rv0581,EnsemblGenomes-Tr:CCP43319,GOA:O53778,InterPro:IPR002145,InterPro:IPR010985,InterPro:IPR013321,NCBI_GP:CCP43319.1;Name=CCP43319.1;Note=Rv0581%2C (MTV039.19)%2C len: 71 aa. Possible vapB26%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0582%2Csee Arcus et al. 2005. Showing weak similarity to other Mycobacterium tuberculosis proteins including P95003|Z83863|Rv2550c|MTCY159_6 conserved hypothetical protein (81 aa)%2C FASTA scores: opt: 93%2C E(): 3.2%2C (25.7%25 identity in 70 aa overlap)%3B Rv2871%3B Rv1241%3B etc. Also shows weak similarity to X05648|SGSPH_1 from Streptomyces glaucescens (77 aa)%2C FASTA scores: opt: 92%2C E(): 3.6%2C(35.4%25 identity in 65 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB26;locus_tag=Rv0581;product=Possible antitoxin VapB26;protein_id=CCP43319.1;transl_table=11
AL123456.3	EMBL	gene	677922	678329	.	+	.	ID=gene-Rv0582;Name=vapC26;gbkey=Gene;gene=vapC26;gene_biotype=protein_coding;locus_tag=Rv0582
AL123456.3	EMBL	CDS	677922	678329	.	+	0	ID=cds-CCP43320.1;Parent=gene-Rv0582;Dbxref=EnsemblGenomes-Gn:Rv0582,EnsemblGenomes-Tr:CCP43320,GOA:O53779,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43320.1;Name=CCP43320.1;Note=Rv0582%2C (MTV039.20)%2C len: 135 aa. Possible vapC26%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0581%2Ccontains PIN domain%2C see Arcus et al. 2005.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC26;locus_tag=Rv0582;product=Possible toxin VapC26. Contains PIN domain.;protein_id=CCP43320.1;transl_table=11
AL123456.3	EMBL	gene	678389	679075	.	-	.	ID=gene-Rv0583c;Name=lpqN;gbkey=Gene;gene=lpqN;gene_biotype=protein_coding;locus_tag=Rv0583c
AL123456.3	EMBL	CDS	678389	679075	.	-	0	ID=cds-CCP43321.1;Parent=gene-Rv0583c;Dbxref=EnsemblGenomes-Gn:Rv0583c,EnsemblGenomes-Tr:CCP43321,GOA:O53780,InterPro:IPR019674,UniProtKB/TrEMBL:O53780,NCBI_GP:CCP43321.1;Name=CCP43321.1;Note=Rv0583c%2C (MTV039.21c)%2C len: 228 aa. Probable lpqN%2Cconserved lipoprotein%2C equivalent to AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein precursor from Mycobacterium kansasii (225 aa)%2C FASTA scores: opt: 945%2C E(): 0%2C (62.7%25 identity in 228 aa overlap)%3B and similar to others from Mycobacteria e.g. Rv0040c and Rv1016c from Mycobacterium tuberculosis. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqN;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0583c;product=Probable conserved lipoprotein LpqN;protein_id=CCP43321.1;transl_table=11
AL123456.3	EMBL	gene	679229	681862	.	+	.	ID=gene-Rv0584;Name=Rv0584;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0584
AL123456.3	EMBL	CDS	679229	681862	.	+	0	ID=cds-CCP43322.1;Parent=gene-Rv0584;Dbxref=EnsemblGenomes-Gn:Rv0584,EnsemblGenomes-Tr:CCP43322,GOA:O86365,InterPro:IPR005887,InterPro:IPR008928,InterPro:IPR012939,InterPro:IPR014718,NCBI_GP:CCP43322.1;Name=CCP43322.1;Note=Rv0584%2C (MTV039.22)%2C len: 877 aa. Possible conserved exported protein%2C similar to other hypothetical proteins which are not necessarily secreted e.g. CAB61925.1|AL133278 putative secreted protein from Streptomyces coelicolor (772 aa)%3B AAD51075.1|AF175722_1|AF175722 immunoreactive 89kD antigen PG87 from Porphyromonas gingivalis (781 aa)%2C FASTA scores: opt: 637%2C E(): 2.1e-30%2C (29.1%25 identity in 794 aa overlap)%3B etc. Contains PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. Has potential N-terminal signal peptide. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;inference=protein motif:PROSITE:PS00699;locus_tag=Rv0584;product=Possible conserved exported protein;protein_id=CCP43322.1;transl_table=11
AL123456.3	EMBL	gene	681885	684272	.	-	.	ID=gene-Rv0585c;Name=Rv0585c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0585c
AL123456.3	EMBL	CDS	681885	684272	.	-	0	ID=cds-CCP43323.1;Parent=gene-Rv0585c;Dbxref=EnsemblGenomes-Gn:Rv0585c,EnsemblGenomes-Tr:CCP43323,GOA:O53781,InterPro:IPR011009,InterPro:IPR022791,UniProtKB/TrEMBL:O53781,NCBI_GP:CCP43323.1;Name=CCP43323.1;Note=Rv0585c%2C (MTV039.23c%2C MTCY19H5.37)%2C len: 795 aa. Probable conserved integral membrane protein. C-terminus similar to CAB88984.1|AL353864 putative integral membrane protein from Streptomyces coelicolor (299 aa)%3B and C-terminal region of CAC01311.1|AL390968 putative integral membrane protein from Streptomyces coelicolor (925 aa). Also some similarity with Rv0204 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0585c;product=Probable conserved integral membrane protein;protein_id=CCP43323.1;transl_table=11
AL123456.3	EMBL	gene	684410	685132	.	+	.	ID=gene-Rv0586;Name=mce2R;gbkey=Gene;gene=mce2R;gene_biotype=protein_coding;locus_tag=Rv0586
AL123456.3	EMBL	CDS	684410	685132	.	+	0	ID=cds-CCP43324.1;Parent=gene-Rv0586;Dbxref=EnsemblGenomes-Gn:Rv0586,EnsemblGenomes-Tr:CCP43324,GOA:P9WMG5,InterPro:IPR000524,InterPro:IPR008920,InterPro:IPR011711,InterPro:IPR011991,NCBI_GP:CCP43324.1;Name=CCP43324.1;Note=Rv0586%2C (MTCY19H5.36c)%2C len: 240 aa. Probable mce2R%2Ctranscriptional regulator%2C GntR family%2C part of mce2 operon%2C similar to many e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase operon regulatory protein from Escherichia coli (258 aa)%2C FASTA scores: opt: 225%2C E(): 9.3e-08%2C (26.7%25 identity in 232 aa overlap)%3B etc. Also similar to other M. tuberculosis transcriptional regulators GntR proteins e.g. Rv3060c%2C Rv0792c%2C etc. Contains PS00043 Bacterial regulatory proteins%2C gntR family signature and probable helix-turn helix motif from aa 35-56 (Score 1531%2C+4.40 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce2R;inference=protein motif:PROSITE:PS00043;locus_tag=Rv0586;product=Probable transcriptional regulatory protein Mce2R (GntR-family);protein_id=CCP43324.1;transl_table=11
AL123456.3	EMBL	gene	685129	685926	.	+	.	ID=gene-Rv0587;Name=yrbE2A;gbkey=Gene;gene=yrbE2A;gene_biotype=protein_coding;locus_tag=Rv0587
AL123456.3	EMBL	CDS	685129	685926	.	+	0	ID=cds-CCP43325.1;Parent=gene-Rv0587;Dbxref=EnsemblGenomes-Gn:Rv0587,EnsemblGenomes-Tr:CCP43325,InterPro:IPR003453,UniProtKB/TrEMBL:I6Y870,NCBI_GP:CCP43325.1;Name=CCP43325.1;Note=Rv0587%2C (MTCY19H5.35c)%2C len: 265 aa. YrbE2A%2Chypothetical unknown integral membrane protein%2C part of mce2 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa)%3B O53965|Rv1964|MTV051.02|yrbE3A (265 aa)%3B etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEA type%2C e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa)%2C FASTA scores: opt: 287%2C E(): 6.1e-12%2C (21.5%25 identity in 256 aa overlap)%3B P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa)%2C FASTA scores: opt: 311%2C E(): 1.8e-83%2C (24.2%25 identity in 265 aa overlap)%3B NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa)%3B etc.;gbkey=CDS;gene=yrbE2A;locus_tag=Rv0587;product=Conserved hypothetical integral membrane protein YrbE2A;protein_id=CCP43325.1;transl_table=11
AL123456.3	EMBL	gene	685928	686815	.	+	.	ID=gene-Rv0588;Name=yrbE2B;gbkey=Gene;gene=yrbE2B;gene_biotype=protein_coding;locus_tag=Rv0588
AL123456.3	EMBL	CDS	685928	686815	.	+	0	ID=cds-CCP43326.1;Parent=gene-Rv0588;Dbxref=EnsemblGenomes-Gn:Rv0588,EnsemblGenomes-Tr:CCP43326,GOA:O07790,InterPro:IPR003453,UniProtKB/TrEMBL:O07790,NCBI_GP:CCP43326.1;Name=CCP43326.1;Note=Rv0588%2C (MTCY19H5.34c)%2C len: 295 aa. YrbE2B%2Chypothetical unknown integral membrane protein%2C part of mce2 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa)%3B O53966|Rv1965|MTV051.03|yrbE3B (271 aa)%3B etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type%2C e.g. P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa)%2C FASTA scores: opt: 232%2C E(): 8.4e-08%2C (22.1 %25 identity in 267 aa overlap)%3B P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa)%2C FASTA scores: opt: 234%2C E(): 6.3e-08%2C (24.2%25 identity in 215 aa overlap)%3B NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yrbE2B;locus_tag=Rv0588;product=Conserved hypothetical integral membrane protein YrbE2B;protein_id=CCP43326.1;transl_table=11
AL123456.3	EMBL	gene	686821	688035	.	+	.	ID=gene-Rv0589;Name=mce2A;gbkey=Gene;gene=mce2A;gene_biotype=protein_coding;gene_synonym=mce2;locus_tag=Rv0589
AL123456.3	EMBL	CDS	686821	688035	.	+	0	ID=cds-CCP43327.1;Parent=gene-Rv0589;Dbxref=EnsemblGenomes-Gn:Rv0589,EnsemblGenomes-Tr:CCP43327,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR024516,UniProtKB/TrEMBL:Q79FY7,NCBI_GP:CCP43327.1;Name=CCP43327.1;Note=Rv0589%2C (MTCY19H5.33c)%2C len: 404 aa. Mce2A%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa)%3B O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa)%3B etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa)%3B NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa)%3B CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa)%3B etc. Also highly similar%2C but longer 21 aa%2C to P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from Mycobacterium tuberculosis (432 aa)%2C FASTA scores: opt: 1324%2C E(): 0%2C (62.6%25 identity in 436 aa overlap). Contains a possible N-terminal signal or anchor sequence. Predicted to be an outer membrane protein (See Song et al.%2C 2008). Note that previously known as mce2.;gbkey=CDS;gene=mce2A;locus_tag=Rv0589;product=Mce-family protein Mce2A;protein_id=CCP43327.1;transl_table=11
AL123456.3	EMBL	gene	688032	688859	.	+	.	ID=gene-Rv0590;Name=mce2B;gbkey=Gene;gene=mce2B;gene_biotype=protein_coding;locus_tag=Rv0590
AL123456.3	EMBL	CDS	688032	688859	.	+	0	ID=cds-CCP43328.1;Parent=gene-Rv0590;Dbxref=EnsemblGenomes-Gn:Rv0590,EnsemblGenomes-Tr:CCP43328,GOA:O07788,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O07788,NCBI_GP:CCP43328.1;Name=CCP43328.1;Note=Rv0590%2C (MTCY19H5.32c)%2C len: 275 aa. Mce2B%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa)%3B O53968|Rv1967|MTV051.05|mce3B (342 aa)%3B etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa)%3B P45391|YRBD_ECOLI hypothetical 19.6 kDa protein from Escherichia coli (183 aa)%2C FASTA scores: opt: 160%2C E(): 0.00099%2C (28.3%25 identity in 166 aa overlap)%3B P45029|YRBD_HAEIN|HI1085 hypothetical protein from Haemophilus influenzae (167 aa)%2C FASTA scores: opt: 135%2CE():0.035%2C (25.9%25 identity in 143 aa overlap)%3B etc. Contains possible N-terminal signal or anchor sequence. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce2B;locus_tag=Rv0590;product=Mce-family protein Mce2B;protein_id=CCP43328.1;transl_table=11
AL123456.3	EMBL	gene	688808	689062	.	+	.	ID=gene-Rv0590A;Name=Rv0590A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0590A
AL123456.3	EMBL	CDS	688808	689062	.	+	0	ID=cds-CCP43329.1;Parent=gene-Rv0590A;Dbxref=EnsemblGenomes-Gn:Rv0590A,EnsemblGenomes-Tr:CCP43329,UniProtKB/TrEMBL:I6X9D2,NCBI_GP:CCP43329.1;Name=CCP43329.1;Note=Rv0590A%2C len: 84 aa. Probable continuation of mce2B|Rv0590. Can find no frameshift to account for this. Possible nucleotide G missing at 688793 as there are 5 in Mycobacterium bovis but only 4 in CDC1551. Strong similarity to C-terminus of other Mce proteins e.g. AL583926|AL583926_38 from Mycobacterium leprae strain tn (346 aa)%2C FASTA scores: E(): 1.2e-20%2C (67.85%25 identity in 84 aa overlap).;gbkey=CDS;locus_tag=Rv0590A;product=Mce-family related protein;protein_id=CCP43329.1;transl_table=11
AL123456.3	EMBL	gene	689059	690504	.	+	.	ID=gene-Rv0591;Name=mce2C;gbkey=Gene;gene=mce2C;gene_biotype=protein_coding;locus_tag=Rv0591
AL123456.3	EMBL	CDS	689059	690504	.	+	0	ID=cds-CCP43330.1;Parent=gene-Rv0591;Dbxref=EnsemblGenomes-Gn:Rv0591,EnsemblGenomes-Tr:CCP43330,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR008360,UniProtKB/TrEMBL:O07787,NCBI_GP:CCP43330.1;Name=CCP43330.1;Note=Rv0591%2C (MTCY19H5.31c)%2C len: 481 aa. Mce2C%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa)%3B O53969|Rv1968|MTV051.06|mce3C (410 aa)%3B etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa)%3B CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and may contain N-terminal signal or anchor sequence. Has highly Pro-rich C-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce2C;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0591;product=Mce-family protein Mce2C;protein_id=CCP43330.1;transl_table=11
AL123456.3	EMBL	gene	690501	692027	.	+	.	ID=gene-Rv0592;Name=mce2D;gbkey=Gene;gene=mce2D;gene_biotype=protein_coding;locus_tag=Rv0592
AL123456.3	EMBL	CDS	690501	692027	.	+	0	ID=cds-CCP43331.1;Parent=gene-Rv0592;Dbxref=EnsemblGenomes-Gn:Rv0592,EnsemblGenomes-Tr:CCP43331,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:I6WYT7,NCBI_GP:CCP43331.1;Name=CCP43331.1;Note=Rv0592%2C (MTCY19H5.30c)%2C len: 508 aa. Mce2D%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa)%3B O53970|Rv1969|MTV051.07|mce3D (423 aa)%3B etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa)%3B CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa)%3B etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce2D;locus_tag=Rv0592;product=Mce-family protein Mce2D;protein_id=CCP43331.1;transl_table=11
AL123456.3	EMBL	gene	692024	693232	.	+	.	ID=gene-Rv0593;Name=lprL;gbkey=Gene;gene=lprL;gene_biotype=protein_coding;gene_synonym=mce2E;locus_tag=Rv0593
AL123456.3	EMBL	CDS	692024	693232	.	+	0	ID=cds-CCP43332.1;Parent=gene-Rv0593;Dbxref=EnsemblGenomes-Gn:Rv0593,EnsemblGenomes-Tr:CCP43332,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:I6Y461,NCBI_GP:CCP43332.1;Name=CCP43332.1;Note=Rv0593%2C (MTCY19H5.29c)%2C len: 402 aa. Possible lprL (alternate gene name: mce2E)%2C lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa)%3B O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa)%3B etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa)%3B CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa)%3B etc. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lprL;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0593;product=Possible Mce-family lipoprotein LprL (Mce-family lipoprotein Mce2E);protein_id=CCP43332.1;transl_table=11
AL123456.3	EMBL	gene	693237	694787	.	+	.	ID=gene-Rv0594;Name=mce2F;gbkey=Gene;gene=mce2F;gene_biotype=protein_coding;locus_tag=Rv0594
AL123456.3	EMBL	CDS	693237	694787	.	+	0	ID=cds-CCP43333.1;Parent=gene-Rv0594;Dbxref=EnsemblGenomes-Gn:Rv0594,EnsemblGenomes-Tr:CCP43333,GOA:O07784,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O07784,NCBI_GP:CCP43333.1;Name=CCP43333.1;Note=Rv0594%2C (MTCY19H5.28c)%2C len: 516 aa. Mce2F%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa)%3B O53972|Rv1971|MTV051.09|mce3F (437 aa)%3B etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa)%3B AAF74993.1|AF143400_1|AF143400|996A027a protein from Mycobacterium avium (80 aa) (similarity on C-terminus)%3B CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa)%3B etc. Contains possible N-terminal signal or anchor sequence. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=mce2F;locus_tag=Rv0594;product=Mce-family protein Mce2F;protein_id=CCP43333.1;transl_table=11
AL123456.3	EMBL	gene	694839	695231	.	-	.	ID=gene-Rv0595c;Name=vapC4;gbkey=Gene;gene=vapC4;gene_biotype=protein_coding;locus_tag=Rv0595c
AL123456.3	EMBL	CDS	694839	695231	.	-	0	ID=cds-CCP43334.1;Parent=gene-Rv0595c;Dbxref=EnsemblGenomes-Gn:Rv0595c,EnsemblGenomes-Tr:CCP43334,GOA:O07783,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43334.1;Name=CCP43334.1;Note=Rv0595c%2C (MTCY19H5.27)%2C len: 130 aa. Possible vapC4%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0596c%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to other conserved hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112 aa) from Mycobacterium tuberculosis%3B and STBB_PSESM|Q52562 plasmid stability protein from Pseudomonas syringae (139 aa)%2C FASTA scores: opt: 131%2C E(): 0.0035%2C (35.2%25 identity in 88 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC4;locus_tag=Rv0595c;product=Possible toxin VapC4;protein_id=CCP43334.1;transl_table=11
AL123456.3	EMBL	gene	695228	695485	.	-	.	ID=gene-Rv0596c;Name=vapB4;gbkey=Gene;gene=vapB4;gene_biotype=protein_coding;locus_tag=Rv0596c
AL123456.3	EMBL	CDS	695228	695485	.	-	0	ID=cds-CCP43335.1;Parent=gene-Rv0596c;Dbxref=EnsemblGenomes-Gn:Rv0596c,EnsemblGenomes-Tr:CCP43335,GOA:P9WF21,InterPro:IPR006442,NCBI_GP:CCP43335.1;Name=CCP43335.1;Note=Rv0596c%2C (MTCY19H5.26)%2C len: 85 aa. Possible vapB4%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0595c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Highly similar in part to other M. tuberculosis hypothetical proteins e.g. Rv0626%2C Rv3181c%2C Rv3385c%2C Rv3407%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=vapB4;locus_tag=Rv0596c;product=Possible antitoxin VapB4;protein_id=CCP43335.1;transl_table=11
AL123456.3	EMBL	gene	695668	696903	.	-	.	ID=gene-Rv0597c;Name=Rv0597c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0597c
AL123456.3	EMBL	CDS	695668	696903	.	-	0	ID=cds-CCP43336.1;Parent=gene-Rv0597c;Dbxref=EnsemblGenomes-Gn:Rv0597c,EnsemblGenomes-Tr:CCP43336,InterPro:IPR025420,InterPro:IPR027417,UniProtKB/TrEMBL:I6WYU2,NCBI_GP:CCP43336.1;Name=CCP43336.1;Note=Rv0597c%2C (MTCY19H5.25)%2C len: 411 aa. Conserved hypothetical protein%2C highly similar to Rv3179 conserved hypothetical protein from Mycobacterium tuberculosis (429 aa). Also similar to AAF76191.1|AF271296_1|AF271296 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa)%3B Rv2008c|YW09_MYCTU|Q10849 conserved hypothetical protein from Mycobacterium tuberculosis (441 aa)%2C FASTA scores: opt: 270%2C E(): 3.6e-11%2C (30.5%25 identity in 416 aa overlap) (N-terminus longer). Also similar to other hypothetical proteins e.g. NP_085874.1|NC_002679 hypothetical protein from Mesorhizobium loti (435 aa) (N-terminus longer). Contains PS00017 ATP/GTP-binding site motif A (P-loop). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0597c;product=Conserved hypothetical protein;protein_id=CCP43336.1;transl_table=11
AL123456.3	EMBL	gene	697154	697567	.	-	.	ID=gene-Rv0598c;Name=vapC27;gbkey=Gene;gene=vapC27;gene_biotype=protein_coding;locus_tag=Rv0598c
AL123456.3	EMBL	CDS	697154	697567	.	-	0	ID=cds-CCP43337.1;Parent=gene-Rv0598c;Dbxref=EnsemblGenomes-Gn:Rv0598c,EnsemblGenomes-Tr:CCP43337,GOA:P9WF83,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43337.1;Name=CCP43337.1;Note=Rv0598c%2C (MTCY19H5.24)%2C len: 137 aa. Possible vapC27%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv00599c%2C contains PIN domain%2C see Arcus et al. 2005. Similar to others e.g. Rv2596|Y0B5_MYCTU|Q50625 conserved hypothetical protein from Mycobacterium tuberculosis (134 aa)%2C FASTA scores: opt: 254%2C E(): 8.2e-12%2C (41.5%25 identity in 130 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC27;locus_tag=Rv0598c;product=Possible toxin VapC27. Contains PIN domain.;protein_id=CCP43337.1;transl_table=11
AL123456.3	EMBL	gene	697564	697800	.	-	.	ID=gene-Rv0599c;Name=vapB27;gbkey=Gene;gene=vapB27;gene_biotype=protein_coding;locus_tag=Rv0599c
AL123456.3	EMBL	CDS	697564	697800	.	-	0	ID=cds-CCP43338.1;Parent=gene-Rv0599c;Dbxref=EnsemblGenomes-Gn:Rv0599c,EnsemblGenomes-Tr:CCP43338,GOA:O07779,InterPro:IPR007159,NCBI_GP:CCP43338.1;Name=CCP43338.1;Note=Rv0599c%2C (MTCY19H5.23)%2C len: 78 aa. Possible vapB27%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0598c%2C see Arcus et al. 2005. Similar to others e.g. Rv2595|Y0B6_MYCTU|Q50626 conserved hypothetical protein from Mycobacterium tuberculosis (81 aa)%2C FASTA scores: opt: 160%2C E(): 6.2e-07%2C (35.8%25 identity in 81 aa overlap). N-terminus shows stong similarity with N-terminus of NP_104908.1|NC_002678 hypothetical protein from Mesorhizobium loti (89 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB27;locus_tag=Rv0599c;product=Possible antitoxin VapB27;protein_id=CCP43338.1;transl_table=11
AL123456.3	EMBL	gene	697904	698410	.	-	.	ID=gene-Rv0600c;Name=Rv0600c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0600c
AL123456.3	EMBL	CDS	697904	698410	.	-	0	ID=cds-CCP43339.1;Parent=gene-Rv0600c;Dbxref=EnsemblGenomes-Gn:Rv0600c,EnsemblGenomes-Tr:CCP43339,GOA:O07778,InterPro:IPR003594,InterPro:IPR004358,InterPro:IPR005467,NCBI_GP:CCP43339.1;Name=CCP43339.1;Note=Rv0600c%2C (MTCY19H5.22)%2C len: 168 aa (probable partial CDS). Two-component sensor kinase (second part)%2Csimilar to part (C-termini) of many others e.g. Q04943|AFQ2_STRCO sensor protein afsq2 from Streptomyces coelicolor (535 aa)%2C FASTA scores: opt: 347%2C E(): 1.9e-12%2C(33.0%25 identity in 206 aa overlap)%3B etc. Note that sequence was checked and no errors were detected%2C which would allow this and the upstream ORF to be joined. Start changed since first submission (- 39 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0600c;product=Two component sensor kinase [second part];protein_id=CCP43339.1;transl_table=11
AL123456.3	EMBL	gene	698524	698994	.	-	.	ID=gene-Rv0601c;Name=Rv0601c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0601c
AL123456.3	EMBL	CDS	698524	698994	.	-	0	ID=cds-CCP43340.1;Parent=gene-Rv0601c;Dbxref=EnsemblGenomes-Gn:Rv0601c,EnsemblGenomes-Tr:CCP43340,GOA:O07777,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR009082,NCBI_GP:CCP43340.1;Name=CCP43340.1;Note=Rv0601c%2C (MTCY19H5.21)%2C len: 156 aa (probable partial CDS). Two-component sensor kinase (first part)%2Csimilar to part (N-termini) of others e.g. Q0375|CUTS_STRLI cuts protein from streptomyces lividans (414 aa)%2C FASTA scores: opt: 230%2C E(): 3.1e-08%2C (39.1%25 identity in 115 aa overlap). Note that the sequence was checked and no errors were detected that would allow this and the downstream ORF to be joined. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0601c;product=Two component sensor kinase [first part];protein_id=CCP43340.1;transl_table=11
AL123456.3	EMBL	gene	699038	699799	.	-	.	ID=gene-Rv0602c;Name=tcrA;gbkey=Gene;gene=tcrA;gene_biotype=protein_coding;locus_tag=Rv0602c
AL123456.3	EMBL	CDS	699038	699799	.	-	0	ID=cds-CCP43341.1;Parent=gene-Rv0602c;Dbxref=EnsemblGenomes-Gn:Rv0602c,EnsemblGenomes-Tr:CCP43341,GOA:O07776,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,NCBI_GP:CCP43341.1;Name=CCP43341.1;Note=Rv0602c%2C (MTCY19H5.20)%2C len: 253 aa. tcrA%2Ctwo-component DNA-binding response regulator%2C highly similar to others e.g. NP_107959.1|NC_002678 two-component response regulator from Mesorhizobium loti (239 aa)%3B etc. Also similar to many other Mycobacterium tuberculosis two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c response regulator homolog TRCR (TCRV) (257 aa)%2C FASTA score: (47.4 identity in 232 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tcrA;locus_tag=Rv0602c;product=Two component DNA binding transcriptional regulatory protein TcrA;protein_id=CCP43341.1;transl_table=11
AL123456.3	EMBL	gene	699856	700167	.	+	.	ID=gene-Rv0603;Name=Rv0603;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0603
AL123456.3	EMBL	CDS	699856	700167	.	+	0	ID=cds-CCP43342.1;Parent=gene-Rv0603;Dbxref=EnsemblGenomes-Gn:Rv0603,EnsemblGenomes-Tr:CCP43342,InterPro:IPR025711,PDB:2KGY,PDB:2LRA,UniProtKB/TrEMBL:O07775,NCBI_GP:CCP43342.1;Name=CCP43342.1;Note=Rv0603%2C (MTCY19H5.19c)%2C len: 103 aa. Possible exported protein with hydrophobic stretch at aa 7-29. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0603;product=Possible exported protein;protein_id=CCP43342.1;transl_table=11
AL123456.3	EMBL	gene	700239	701189	.	+	.	ID=gene-Rv0604;Name=lpqO;gbkey=Gene;gene=lpqO;gene_biotype=protein_coding;locus_tag=Rv0604
AL123456.3	EMBL	CDS	700239	701189	.	+	0	ID=cds-CCP43343.1;Parent=gene-Rv0604;Dbxref=EnsemblGenomes-Gn:Rv0604,EnsemblGenomes-Tr:CCP43343,InterPro:IPR011094,UniProtKB/TrEMBL:I6X9E2,NCBI_GP:CCP43343.1;Name=CCP43343.1;Note=Rv0604%2C (MTCY19H5.18c)%2C len: 316 aa. Probable lpqO%2Cconserved lipoprotein%2C highly similar to Rv2999|lppY putative lipoprotein from Mycobacterium tuberculosis (321 aa)%2C FASTA scores: opt: 1153%2C E(): 0%2C (53.2%25 identity in 312 aa overlap). Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqO;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0604;product=Probable conserved lipoprotein LpqO;protein_id=CCP43343.1;transl_table=11
AL123456.3	EMBL	repeat_region	701247	701369	.	-	.	ID=id-AL123456.3:701247..701369;Note=123 bp imperfect direct repeat 2%2C 92/103 bp identical to first copy at 709425..709548%2C AGCCCCGGCTCGACGCGGCATAGGGTGGCCACCGTGGCCGAAGCGTTCCATGCGACCG TGCCGTGGCGAGGATCCCGGCCGAACATGGCCCATTGAACGAGGACGTCATCGCACGA CGCCTGC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	701384	702767	.	+	.	ID=id-AL123456.3:701384..702767;Note=IS1536%2C len: 1384 nt. Partial copy of insertion sequence IS_1536. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1536
AL123456.3	EMBL	gene	701406	702014	.	+	.	ID=gene-Rv0605;Name=Rv0605;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0605
AL123456.3	EMBL	CDS	701406	702014	.	+	0	ID=cds-CCP43344.1;Parent=gene-Rv0605;Dbxref=EnsemblGenomes-Gn:Rv0605,EnsemblGenomes-Tr:CCP43344,GOA:I6Y890,InterPro:IPR006118,InterPro:IPR006119,UniProtKB/TrEMBL:I6Y890,NCBI_GP:CCP43344.1;Name=CCP43344.1;Note=Rv0605%2C (MTCY19H5.17c)%2C len: 202 aa. Possible resolvase for IS_Y349 element%2C similar to several Mycobacterial hypothetical proteins and weakly similar to Q52563 resolvase from Pseudomonas syringae (210 aa)%2C FASTA scores: opt: 99%2C E(): 3.1%2C (35.7%25 identity in 98 aa overlap). Contains PS00397 Site-specific recombinases active site and probable helix-turn helix motif from aa 9-30 (Score 1815%2C +5.37 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00397;locus_tag=Rv0605;product=Possible resolvase;protein_id=CCP43344.1;transl_table=11
AL123456.3	EMBL	gene	702016	702759	.	+	.	ID=gene-Rv0606;Name=Rv0606;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0606
AL123456.3	EMBL	CDS	702016	702759	.	+	0	ID=cds-CCP43345.1;Parent=gene-Rv0606;Dbxref=EnsemblGenomes-Gn:Rv0606,EnsemblGenomes-Tr:CCP43345,InterPro:IPR001959,InterPro:IPR021027,UniProtKB/TrEMBL:O07772,NCBI_GP:CCP43345.1;Name=CCP43345.1;Note=Rv0606%2C (MTCY19H5.16c)%2C len: 247 aa. Possible truncated transposase for IS_1536 element%2C highly similar to N-terminus of other transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c putative transposase from Mycobacterium tuberculosis (460 aa)%2C FASTA scores: opt: 1368%2C E(): 0%2C (83.5%25 identity in 237 aa overlap)%3B Rv2978c%2C Rv0922%2C Rv3827c%2C etc. Also similar to N-terminus of MTV002_57|Rv2792 resolvase from M. tuberculosis (193 aa)%2C FASTA score: (87.4%25 identity in 238 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0606;product=Possible transposase (fragment);protein_id=CCP43345.1;transl_table=11
AL123456.3	EMBL	gene	702813	703199	.	+	.	ID=gene-Rv0607;Name=Rv0607;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0607
AL123456.3	EMBL	CDS	702813	703199	.	+	0	ID=cds-CCP43346.1;Parent=gene-Rv0607;Dbxref=EnsemblGenomes-Gn:Rv0607,EnsemblGenomes-Tr:CCP43346,GOA:O07771,UniProtKB/TrEMBL:O07771,NCBI_GP:CCP43346.1;Name=CCP43346.1;Note=Rv0607%2C (MTCY19H5.15c)%2C len: 128 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0607;product=Hypothetical protein;protein_id=CCP43346.1;transl_table=11
AL123456.3	EMBL	gene	703244	703489	.	+	.	ID=gene-Rv0608;Name=vapB28;gbkey=Gene;gene=vapB28;gene_biotype=protein_coding;locus_tag=Rv0608
AL123456.3	EMBL	CDS	703244	703489	.	+	0	ID=cds-CCP43347.1;Parent=gene-Rv0608;Dbxref=EnsemblGenomes-Gn:Rv0608,EnsemblGenomes-Tr:CCP43347,GOA:P9WJ39,InterPro:IPR011660,NCBI_GP:CCP43347.1;Name=CCP43347.1;Note=Rv0608%2C (MTCY19H5.14c)%2C len: 81 aa. Possible vapB28%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0609%2Csee Arcus et al. 2005. Similar to several others e.g. Rv0623|P96913|MTCY20H10.04 (84 aa)%2C FASTA scores: opt: 159%2CE(): 1.2e-09%2C (43.0%25 identity in 86 aa overlap)%3B Rv2760c (89 aa)%3B Rv1740 (70 aa)%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=vapB28;locus_tag=Rv0608;product=Possible antitoxin VapB28;protein_id=CCP43347.1;transl_table=11
AL123456.3	EMBL	gene	703486	703887	.	+	.	ID=gene-Rv0609;Name=vapC28;gbkey=Gene;gene=vapC28;gene_biotype=protein_coding;locus_tag=Rv0609
AL123456.3	EMBL	CDS	703486	703887	.	+	0	ID=cds-CCP43348.1;Parent=gene-Rv0609;Dbxref=EnsemblGenomes-Gn:Rv0609,EnsemblGenomes-Tr:CCP43348,GOA:P9WF81,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43348.1;Name=CCP43348.1;Note=Rv0609%2C (MTCY19H5.13c)%2C len: 133 aa. Possible vapC28%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv0608%2C contains PIN domain%2C see Arcus et al. 2005. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37 conserved hypothetical protein (139 aa)%2C FASTA scores: opt: 262%2C E(): 8.1e-12%2C (39.1%25 identity in 128 aa overlap)%3B MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05 conserved hypothetical protein (131 aa)%2C FASTA score: (42.9%25 identity in 126 aa overlap)%2C Rv0565c%2C Rv3854c%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC28;locus_tag=Rv0609;product=Possible toxin VapC28. Contains PIN domain.;protein_id=CCP43348.1;transl_table=11
AL123456.3	EMBL	gene	703830	704057	.	+	.	ID=gene-Rv0609A;Name=Rv0609A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0609A
AL123456.3	EMBL	CDS	703830	704057	.	+	0	ID=cds-CCP43349.1;Parent=gene-Rv0609A;Dbxref=EnsemblGenomes-Gn:Rv0609A,EnsemblGenomes-Tr:CCP43349,UniProtKB/TrEMBL:Q79FY5,NCBI_GP:CCP43349.1;Name=CCP43349.1;Note=Rv0609A%2C len: 75 aa. Conserved hypothetical protein%2Chighly similar to part of upstream ORF Rv0612|MTCY19H5.09c conserved hypothetical protein from Mycobacterium tuberculosis (201 aa)%2C FASTA scores: opt: 154%2C E(): 1.8e-05%2C (74.3%25 identity in 35 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0609A;product=Conserved hypothetical protein;protein_id=CCP43349.1;transl_table=11
AL123456.3	EMBL	repeat_region	703912	703985	.	-	.	ID=id-AL123456.3:703912..703985;Note=74 bp imperfect direct repeat 2%2C 64/73 bp identical to first copy at 706790..706863%2C CACAGCGGACACCACAAAGCCCGCCGCTGCCACCGGATCGTCGGAACGAAAATAGTCG TACCCGTGAGCCTCGC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	704187	704247	.	+	.	ID=gene-B55;Name=B55;gbkey=Gene;gene=B55;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	704187	704247	.	+	.	ID=rna-B55;Parent=gene-B55;Note=B55%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=ncRNA;gene=B55;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	704187	704247	.	+	.	ID=exon-B55-1;Parent=rna-B55;Note=B55%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=ncRNA;gene=B55;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	704752	705909	.	-	.	ID=gene-Rv0610c;Name=Rv0610c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0610c
AL123456.3	EMBL	CDS	704752	705909	.	-	0	ID=cds-CCP43350.1;Parent=gene-Rv0610c;Dbxref=EnsemblGenomes-Gn:Rv0610c,EnsemblGenomes-Tr:CCP43350,UniProtKB/TrEMBL:I6Y481,NCBI_GP:CCP43350.1;Name=CCP43350.1;Note=Rv0610c%2C (MTCY19H5.11)%2C len: 385 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0610c;product=Hypothetical protein;protein_id=CCP43350.1;transl_table=11
AL123456.3	EMBL	gene	705961	706344	.	-	.	ID=gene-Rv0611c;Name=Rv0611c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0611c
AL123456.3	EMBL	CDS	705961	706344	.	-	0	ID=cds-CCP43351.1;Parent=gene-Rv0611c;Dbxref=EnsemblGenomes-Gn:Rv0611c,EnsemblGenomes-Tr:CCP43351,UniProtKB/TrEMBL:I6XVR9,NCBI_GP:CCP43351.1;Name=CCP43351.1;Note=Rv0611c%2C (MTCY19H5.10)%2C len: 127 aa. Hypothetical unknown protein. Note that first start has been taken although this overlaps slightly with the upstream ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0611c;product=Hypothetical protein;protein_id=CCP43351.1;transl_table=11
AL123456.3	EMBL	gene	706324	706929	.	+	.	ID=gene-Rv0612;Name=Rv0612;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0612
AL123456.3	EMBL	CDS	706324	706929	.	+	0	ID=cds-CCP43352.1;Parent=gene-Rv0612;Dbxref=EnsemblGenomes-Gn:Rv0612,EnsemblGenomes-Tr:CCP43352,UniProtKB/TrEMBL:I6X9E8,NCBI_GP:CCP43352.1;Name=CCP43352.1;Note=Rv0612%2C (MTCY19H5.09c)%2C len: 201 aa. Conserved hypothetical protein%2C highly similar%2C but in part%2C to downstream ORF Rv0609A conserved hypothetical protein from Mycobacterium tuberculosis (75 aa)%3B and showing weak similarity with other hypothetical proteins from Mycobacterium tuberculosis. Note that first start has been taken although this overlaps slightly with the upstream ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0612;product=Conserved hypothetical protein;protein_id=CCP43352.1;transl_table=11
AL123456.3	EMBL	repeat_region	706790	706863	.	-	.	ID=id-AL123456.3:706790..706863;Note=74 bp imperfect direct repeat 1%2C 64/73 bp identical to second copy at 703912..703985%2C CACATCGGACACGACGAAACCCGCCGCTGCCACCGGATCGTCGGAGCGGAAGTAGTCG TACCCGTCGGCCTCGC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	706948	709515	.	-	.	ID=gene-Rv0613c;Name=Rv0613c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0613c
AL123456.3	EMBL	CDS	706948	709515	.	-	0	ID=cds-CCP43353.1;Parent=gene-Rv0613c;Dbxref=EnsemblGenomes-Gn:Rv0613c,EnsemblGenomes-Tr:CCP43353,InterPro:IPR004027,UniProtKB/TrEMBL:I6Y897,NCBI_GP:CCP43353.1;Name=CCP43353.1;Note=Rv0613c%2C (MTCY19H5.08)%2C len: 855 aa. Unknown protein. Contains a very short region with strong similarity to several preprotein translocases e.g. P47847|SECA_LISMO preprotein translocase seca subunit (836 aa)%2C FASTA scores: opt: 138%2C E(): 0.18%2C (38.6%25 identity in 70 aa overlap%2C and 72.7%25 identity in 22 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0613c;product=Unknown protein;protein_id=CCP43353.1;transl_table=11
AL123456.3	EMBL	gene	709356	710348	.	+	.	ID=gene-Rv0614;Name=Rv0614;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0614
AL123456.3	EMBL	CDS	709356	710348	.	+	0	ID=cds-CCP43354.1;Parent=gene-Rv0614;Dbxref=EnsemblGenomes-Gn:Rv0614,EnsemblGenomes-Tr:CCP43354,GOA:O07763,UniProtKB/TrEMBL:O07763,NCBI_GP:CCP43354.1;Name=CCP43354.1;Note=Rv0614%2C (MTCY19H5.07c)%2C len: 330 aa. Conserved hypothetical protein%2C similar in part to Mycobacterium tuberculosis hypothetical proteins e.g. YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c conserved hypothetical protein (323 aa)%2C FASTA scores: opt: 200%2C E(): 0.00016%2C (28.3%25 identity in 269 aa overlap)%3B MTCY9F9_15 FASTA score: (40.3%25 identity in 144 aa overlap)%2C Rv1949c%2CRv2542%2C etc. Several start sites are possible%3B first start has been chosen. Note that this ORF overlaps with the upstream ORF. Predicted to be an outer membrane protein (See Song et al.%2C 2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0614;product=Conserved hypothetical protein;protein_id=CCP43354.1;transl_table=11
AL123456.3	EMBL	repeat_region	709585	709663	.	+	.	ID=id-Rv0614;Note=79 bp imperfect direct repeat 1%2C 73/78 bp identical to second copy at 711624..711702%2C TAGGGTTCGGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGACGGACGTGAGCT GCTGTTCTTTTCGCTGCCCGG. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region;locus_tag=Rv0614
AL123456.3	EMBL	repeat_region	709425	709548	.	-	.	ID=id-AL123456.3:709425..709548;Note=123 bp imperfect direct repeat 1%2C 92/103 bp identical to second copy at 701247..701369%2C AGCCTCGGCTGGCCGCGGCATAAGGTGGCCACCGTGGCCGAAGCGTTCGATGCGACCC AAGCCGTGGCGAGAATCCTGGCCGAACATGGCCCATTGAGCGAGGACGACATCGCACG ACGCCTGC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	710345	710587	.	+	.	ID=gene-Rv0615;Name=Rv0615;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0615
AL123456.3	EMBL	CDS	710345	710587	.	+	0	ID=cds-CCP43355.1;Parent=gene-Rv0615;Dbxref=EnsemblGenomes-Gn:Rv0615,EnsemblGenomes-Tr:CCP43355,UniProtKB/TrEMBL:O07762,NCBI_GP:CCP43355.1;Name=CCP43355.1;Note=Rv0615%2C (MTCY19H5.06c)%2C len: 80 aa. Probable integral membrane protein.;gbkey=CDS;locus_tag=Rv0615;product=Probable integral membrane protein;protein_id=CCP43355.1;transl_table=11
AL123456.3	EMBL	gene	710584	710850	.	-	.	ID=gene-Rv0616c;Name=Rv0616c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0616c
AL123456.3	EMBL	CDS	710584	710850	.	-	0	ID=cds-CCP43356.1;Parent=gene-Rv0616c;Dbxref=EnsemblGenomes-Gn:Rv0616c,EnsemblGenomes-Tr:CCP43356,UniProtKB/TrEMBL:O07761,NCBI_GP:CCP43356.1;Name=CCP43356.1;Note=Rv0616c%2C (MTCY19H5.05)%2C len: 88 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0616c;product=Hypothetical protein;protein_id=CCP43356.1;transl_table=11
AL123456.3	EMBL	gene	710782	711009	.	+	.	ID=gene-Rv0616A;Name=vapB29;gbkey=Gene;gene=vapB29;gene_biotype=protein_coding;locus_tag=Rv0616A
AL123456.3	EMBL	CDS	710782	711009	.	+	0	ID=cds-CCP43357.1;Parent=gene-Rv0616A;Dbxref=EnsemblGenomes-Gn:Rv0616A,EnsemblGenomes-Tr:CCP43357,NCBI_GP:CCP43357.1;Name=CCP43357.1;Note=Rv0616A%2C len: 75 aa. Possible vapB29%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv0617%2C see Arcus et al. 2005. Similar to many others in M. tuberculosis e.g. Rv2530A (74 aa) 35.9%25 identity in 78 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB29;locus_tag=Rv0616A;product=Possible antitoxin VapB29;protein_id=CCP43357.1;transl_table=11
AL123456.3	EMBL	gene	711006	711407	.	+	.	ID=gene-Rv0617;Name=vapC29;gbkey=Gene;gene=vapC29;gene_biotype=protein_coding;locus_tag=Rv0617
AL123456.3	EMBL	CDS	711006	711407	.	+	0	ID=cds-CCP43358.1;Parent=gene-Rv0617;Dbxref=EnsemblGenomes-Gn:Rv0617,EnsemblGenomes-Tr:CCP43358,GOA:P9WF79,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43358.1;Name=CCP43358.1;Note=Rv0617%2C (MTCY19H5.04c)%2C len: 133 aa. Possible vapC29%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv0616A%2C contains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv2494%2C Rv3320c%2C Rv0749%2C Rv0277c%2C Rv2530c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC29;locus_tag=Rv0617;product=Possible toxin VapC29. Contains PIN domain.;protein_id=CCP43358.1;transl_table=11
AL123456.3	EMBL	gene	711536	712231	.	+	.	ID=gene-Rv0618;Name=galTa;gbkey=Gene;gene=galTa;gene_biotype=protein_coding;gene_synonym=galT';locus_tag=Rv0618
AL123456.3	EMBL	CDS	711536	712231	.	+	0	ID=cds-CCP43359.1;Parent=gene-Rv0618;Dbxref=EnsemblGenomes-Gn:Rv0618,EnsemblGenomes-Tr:CCP43359,GOA:Q79FY4,InterPro:IPR001937,InterPro:IPR005849,InterPro:IPR011146,UniProtKB/TrEMBL:Q79FY4,NCBI_GP:CCP43359.1;Name=CCP43359.1;Note=Rv0618%2C (MTCY19H5.03c)%2C len: 231 aa (probable partial CDS). Probable galTa%2C first part of galactose-1-phosphate uridylyltransferase%2C highly similar to N-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa)%2C FASTA scores: opt: 296%2C E(): 1.4e-11%2C (50.8%25 identity in 177 aa overlap)%3B etc. Also highly similar to N-terminal half of some UDP glucose--hexose-1-phosphate uridylyltransferases. N-terminal 28 aa similar to MTCY20H11.08|Rv0627|MTCY20H11.08 conserved hypothetical protein from Mycobacterium tuberculosis (135 aa)%2C FASTA score: (71.4%25 identity in 28 overlap). Cosmid sequence is correct but there may be a frameshift mutation in this region which would allow the two ORFs to be joined. Belongs to the galactose-1-phosphate uridylyltransferase family 1. Note that previously known as galT'.;gbkey=CDS;gene=galTa;locus_tag=Rv0618;product=Probable galactose-1-phosphate uridylyltransferase GalTa [first part];protein_id=CCP43359.1;transl_table=11
AL123456.3	EMBL	repeat_region	711624	711702	.	+	.	ID=id-Rv0618;Note=79 bp imperfect direct repeat 2%2C 73/78 bp identical to first copy at 709585..709663%2C TAGGGTTCTGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGATGGCCGTGACCT GCTGTTCTTTTCGCTGCCCGG;gbkey=repeat_region;gene=galTa;locus_tag=Rv0618
AL123456.3	EMBL	gene	712174	712719	.	+	.	ID=gene-Rv0619;Name=galTb;gbkey=Gene;gene=galTb;gene_biotype=protein_coding;gene_synonym='galT;locus_tag=Rv0619;partial=true;start_range=.,712174
AL123456.3	EMBL	CDS	712174	712719	.	+	0	ID=cds-CCP43360.1;Parent=gene-Rv0619;Dbxref=EnsemblGenomes-Gn:Rv0619,EnsemblGenomes-Tr:CCP43360,GOA:Q79FY3,InterPro:IPR001937,InterPro:IPR005850,InterPro:IPR011146,UniProtKB/TrEMBL:Q79FY3,NCBI_GP:CCP43360.1;Name=CCP43360.1;Note=Rv0619%2C (MTCY19H5.02c)%2C len: 181 aa (probable partial CDS). Probable galTb%2C second part of galactose-1-phosphate uridylyltransferase%2C highly similar to C-terminal half of other galT proteins e.g. P13212|GAL7_STRLI galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa)%2C FASTA scores: opt: 416%2C E(): 5.2e-22%2C (43.0%25 identity in 186 aa overlap)%2C etc. Cosmid sequence is correct but there may be a frameshift mutation in this region which would allow the two ORFS to be joined. Belongs to the galactose-1-phosphate uridylyltransferase family 1. Note that previously known as 'galT.;gbkey=CDS;gene=galTb;locus_tag=Rv0619;partial=true;product=Probable galactose-1-phosphate uridylyltransferase GalTb [second part];protein_id=CCP43360.1;start_range=.,712174;transl_table=11
AL123456.3	EMBL	gene	712716	713807	.	+	.	ID=gene-Rv0620;Name=galK;gbkey=Gene;gene=galK;gene_biotype=protein_coding;locus_tag=Rv0620
AL123456.3	EMBL	CDS	712716	713807	.	+	0	ID=cds-CCP43361.1;Parent=gene-Rv0620;Dbxref=EnsemblGenomes-Gn:Rv0620,EnsemblGenomes-Tr:CCP43361,GOA:P9WN63,InterPro:IPR000705,InterPro:IPR006204,InterPro:IPR006206,InterPro:IPR013750,InterPro:IPR014721,InterPro:IPR019539,InterPro:IPR019741,InterPro:IPR020568,InterPro:IPR022963,NCBI_GP:CCP43361.1;Name=CCP43361.1;Note=Rv0620%2C (MTCY19H5.01c%2C MTCY20H10.01)%2C len: 363 aa. Probable galK%2C galactokinase%2C similar to others e.g. P13227|GAL1_STRLI galactokinase from Streptomyces lividans (397 aa)%3B P06976|GAL1_ECOLI galactokinase from Escherichia coli (381 aa)%2C FASTA scores: opt: 669%2C E(): 0%2C (35.9%25 identity in 365 aa overlap)%3B etc. Contains PS00106 Galactokinase signature and PS00560 Serine carboxypeptidases%2C histidine active site. Belongs to the GHMP kinase family. GALK subfamily.;gbkey=CDS;gene=galK;inference=protein motif:PROSITE:PS00560;locus_tag=Rv0620;product=Probable galactokinase GalK (galactose kinase);protein_id=CCP43361.1;transl_table=11
AL123456.3	EMBL	gene	714202	715266	.	+	.	ID=gene-Rv0621;Name=Rv0621;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0621
AL123456.3	EMBL	CDS	714202	715266	.	+	0	ID=cds-CCP43362.1;Parent=gene-Rv0621;Dbxref=EnsemblGenomes-Gn:Rv0621,EnsemblGenomes-Tr:CCP43362,UniProtKB/TrEMBL:I6X9F4,NCBI_GP:CCP43362.1;Name=CCP43362.1;Note=Rv0621%2C (MTCY20H10.02)%2C len: 354 aa. Possible membrane protein%3B contains potential membrane spanning regions. Also contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0621;product=Possible membrane protein;protein_id=CCP43362.1;transl_table=11
AL123456.3	EMBL	gene	715370	716317	.	+	.	ID=gene-Rv0622;Name=Rv0622;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0622
AL123456.3	EMBL	CDS	715370	716317	.	+	0	ID=cds-CCP43363.1;Parent=gene-Rv0622;Dbxref=EnsemblGenomes-Gn:Rv0622,EnsemblGenomes-Tr:CCP43363,GOA:P96912,InterPro:IPR007969,UniProtKB/TrEMBL:P96912,NCBI_GP:CCP43363.1;Name=CCP43363.1;Note=Rv0622%2C (MTCY20H10.03)%2C len: 315 aa. Possible membrane protein%3B contains potential membrane spanning region. Shows weak similarity with Mycobacterium tuberculosis hypothetical proteins Rv1804c%2C Rv1810%2C etc. Start changed since first submission (-26 aa).;gbkey=CDS;locus_tag=Rv0622;product=Possible membrane protein;protein_id=CCP43363.1;transl_table=11
AL123456.3	EMBL	gene	716410	716664	.	+	.	ID=gene-Rv0623;Name=vapB30;gbkey=Gene;gene=vapB30;gene_biotype=protein_coding;locus_tag=Rv0623
AL123456.3	EMBL	CDS	716410	716664	.	+	0	ID=cds-CCP43364.1;Parent=gene-Rv0623;Dbxref=EnsemblGenomes-Gn:Rv0623,EnsemblGenomes-Tr:CCP43364,GOA:P9WJ35,InterPro:IPR011660,NCBI_GP:CCP43364.1;Name=CCP43364.1;Note=Rv0623%2C (MTCY20H10.04)%2C len: 84 aa. Possible vapB30%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0624%2Csee Arcus et al. 2005. Also similar to others in Mycobacterium tuberculosis e.g MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 conserved hypothetical protein (70 aa)%2C FASTA score: (73.5%25 identity in 68 aa overlap)%3B MTCY4C12_25|Rv0608|MTCY19H5.14c conserved hypothetical protein (81 aa)%2C FASTA score: (73.5 identity in 68 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB30;locus_tag=Rv0623;product=Possible antitoxin VapB30;protein_id=CCP43364.1;transl_table=11
AL123456.3	EMBL	gene	716664	717059	.	+	.	ID=gene-Rv0624;Name=vapC30;gbkey=Gene;gene=vapC30;gene_biotype=protein_coding;locus_tag=Rv0624
AL123456.3	EMBL	CDS	716664	717059	.	+	0	ID=cds-CCP43365.1;Parent=gene-Rv0624;Dbxref=EnsemblGenomes-Gn:Rv0624,EnsemblGenomes-Tr:CCP43365,GOA:P9WF77,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43365.1;Name=CCP43365.1;Note=Rv0624%2C (MTCY20H10.05)%2C len: 131 aa. Possible vapC30%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv0623%2C contains PIN domain%2C see Arcus et al. 2005. Highly similar to others in Mycobacterium tuberculosis e.g. Rv1741%2C Rv0609%2C Rv2759c%2CRv0565c%2C Rv3854c%2C Rv3083%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC30;locus_tag=Rv0624;product=Possible toxin VapC30. Contains PIN domain.;protein_id=CCP43365.1;transl_table=11
AL123456.3	EMBL	gene	717153	717893	.	-	.	ID=gene-Rv0625c;Name=Rv0625c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0625c
AL123456.3	EMBL	CDS	717153	717893	.	-	0	ID=cds-CCP43366.1;Parent=gene-Rv0625c;Dbxref=EnsemblGenomes-Gn:Rv0625c,EnsemblGenomes-Tr:CCP43366,GOA:P9WFS5,InterPro:IPR015414,NCBI_GP:CCP43366.1;Name=CCP43366.1;Note=Rv0625c%2C (MTCY20H10.06c)%2C len: 246 aa. Probable conserved transmembrane protein%2C showing similarity with others e.g. CAB61866.1|AL133252 putative integral membrane protein from Streptomyces coelicolor (249 aa). Also similar to Rv1491c|MTCY277_13 from Mycobacterium tuberculosis. Contains potential membrane spanning regions.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0625c;product=Probable conserved transmembrane protein;protein_id=CCP43366.1;transl_table=11
AL123456.3	EMBL	gene	718025	718285	.	+	.	ID=gene-Rv0626;Name=vapB5;gbkey=Gene;gene=vapB5;gene_biotype=protein_coding;locus_tag=Rv0626
AL123456.3	EMBL	CDS	718025	718285	.	+	0	ID=cds-CCP43367.1;Parent=gene-Rv0626;Dbxref=EnsemblGenomes-Gn:Rv0626,EnsemblGenomes-Tr:CCP43367,GOA:P9WF19,InterPro:IPR006442,PDB:3DBO,NCBI_GP:CCP43367.1;Name=CCP43367.1;Note=Rv0626%2C (MTCY20H10.07)%2C len: 86 aa. Possible vapB5%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0627 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005).%2C similar to others in Mycobacterium tuberculosis hypothetical proteins e.g. Rv0596c%2C Rv3385c%2C Rv3407%2CRv3181c%2C etc. Cofactor: Mg2+;gbkey=CDS;gene=vapB5;locus_tag=Rv0626;product=Possible antitoxin VapB5;protein_id=CCP43367.1;transl_table=11
AL123456.3	EMBL	gene	718282	718689	.	+	.	ID=gene-Rv0627;Name=vapC5;gbkey=Gene;gene=vapC5;gene_biotype=protein_coding;locus_tag=Rv0627
AL123456.3	EMBL	CDS	718282	718689	.	+	0	ID=cds-CCP43368.1;Parent=gene-Rv0627;Dbxref=EnsemblGenomes-Gn:Rv0627,EnsemblGenomes-Tr:CCP43368,GOA:P96917,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,PDB:3DBO,NCBI_GP:CCP43368.1;Name=CCP43368.1;Note=Rv0627%2C (MTCY20H11.08)%2C len: 135 aa. Possible vapC5%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0626%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Rv0595c and Rv0665.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC5;locus_tag=Rv0627;product=Possible toxin VapC5;protein_id=CCP43368.1;transl_table=11
AL123456.3	EMBL	gene	718761	719912	.	-	.	ID=gene-Rv0628c;Name=Rv0628c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0628c
AL123456.3	EMBL	CDS	718761	719912	.	-	0	ID=cds-CCP43369.1;Parent=gene-Rv0628c;Dbxref=EnsemblGenomes-Gn:Rv0628c,EnsemblGenomes-Tr:CCP43369,GOA:P9WKS7,InterPro:IPR013702,InterPro:IPR016741,InterPro:IPR019494,NCBI_GP:CCP43369.1;Name=CCP43369.1;Note=Rv0628c%2C (MTCY20H10.09c)%2C len: 383 aa. Conserved hypothetical protein%2C highly similar to Rv0874c|YZ02_MYCTU|Q10536 conserved hypothetical protein from Mycobacterium tuberculosis (386 aa)%2C FASTA scores: opt: 2082%2C E(): 0%2C (81.5%25 identity in 383 aa overlap). Also some similarity to P72543|SPU62616_1 hypothetical protein from Synechococcus%2C FASTA scores: E(): 2.8e-28%2C (36.6 identity in 265 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0628c;product=Conserved hypothetical protein;protein_id=CCP43369.1;transl_table=11
AL123456.3	EMBL	gene	720005	721732	.	-	.	ID=gene-Rv0629c;Name=recD;gbkey=Gene;gene=recD;gene_biotype=protein_coding;locus_tag=Rv0629c
AL123456.3	EMBL	CDS	720005	721732	.	-	0	ID=cds-CCP43370.1;Parent=gene-Rv0629c;Dbxref=EnsemblGenomes-Gn:Rv0629c,EnsemblGenomes-Tr:CCP43370,GOA:P9WHJ1,InterPro:IPR006344,InterPro:IPR027417,InterPro:IPR027785,NCBI_GP:CCP43370.1;Name=CCP43370.1;Note=Rv0629c%2C (MTCY20H10.10c)%2C len: 575 aa. Probable recD%2C exonuclease V%2C alpha chain (exodeoxyribonuclease V%2Calpha chain) (see citation below)%2C highly similar to other exonucleases e.g. AF157643_3|AAD46809.1|recD Escherichia coli RecD protein homolog from Mycobacterium smegmatis (554 aa)%3B P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease V 67kd polypeptide (exonuclease V alpha chain) from Escherichia coli strain K12 (608 aa)%2C FASTA scores: opt: 512%2C E(): 1.9e-24%2C (36.9%25 identity in 582 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Consists of three subunits%3B RECB|Rv0630c%2C RECC|Rv0631c and RECD.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recD;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0629c;product=Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide);protein_id=CCP43370.1;transl_table=11
AL123456.3	EMBL	gene	721729	725013	.	-	.	ID=gene-Rv0630c;Name=recB;gbkey=Gene;gene=recB;gene_biotype=protein_coding;locus_tag=Rv0630c
AL123456.3	EMBL	CDS	721729	725013	.	-	0	ID=cds-CCP43371.1;Parent=gene-Rv0630c;Dbxref=EnsemblGenomes-Gn:Rv0630c,EnsemblGenomes-Tr:CCP43371,GOA:P9WMQ3,InterPro:IPR000212,InterPro:IPR004586,InterPro:IPR011335,InterPro:IPR011604,InterPro:IPR014016,InterPro:IPR014017,InterPro:IPR027417,NCBI_GP:CCP43371.1;Name=CCP43371.1;Note=Rv0630c%2C (MTCY20H10.11c)%2C len: 1094 aa. Probable recB%2C exonuclease V%2C beta chain (exodeoxyribonuclease V%2Cbeta chain) (see citation below)%2C highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa)%3B P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease V 135 kDa polypeptide (exonuclease V beta chain) from Escherichia coli strain K12 (1180 aa)%2CFASTA scores: opt: 289%2C E(): 4.3e-11%2C (29.5 identity in 1059 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the helicase family%2C UVRD subfamily. Consists of three subunits%3B RECB%2C RECC|Rv0631c and recd|Rv0629c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recB;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0630c;product=Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease);protein_id=CCP43371.1;transl_table=11
AL123456.3	EMBL	gene	725013	728306	.	-	.	ID=gene-Rv0631c;Name=recC;gbkey=Gene;gene=recC;gene_biotype=protein_coding;locus_tag=Rv0631c
AL123456.3	EMBL	CDS	725013	728306	.	-	0	ID=cds-CCP43372.1;Parent=gene-Rv0631c;Dbxref=EnsemblGenomes-Gn:Rv0631c,EnsemblGenomes-Tr:CCP43372,GOA:P9WIQ5,InterPro:IPR006697,InterPro:IPR011335,InterPro:IPR013986,InterPro:IPR027417,NCBI_GP:CCP43372.1;Name=CCP43372.1;Note=Rv0631c%2C (MTCY20H10.12c)%2C len: 1097 aa. Probable recC%2C exonuclease V%2C gamma chain (exodeoxyribonuclease V%2Cgamma chain) (see Mizrahi %26 Andersen 1998)%2C highly similar to other exonucleases e.g. AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein homolog from Mycobacterium smegmatis (1085 aa)%3B P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease V 125 kDa polypeptide (exonuclease V gamma chain) from Escherichia coli strain K12 (1122 aa)%2CFASTA scores: opt: 954%2C E(): 0%2C (29.2%25 identity in 1109 aa overlap)%3B etc. Consists of three subunits%3B RECB|Rv0630c%2CRECC and recd|Rv0629c. The transcription of this CDS seems to be activated specifically in host granulomas (see Ramakrishnan et al.%2C 2000).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recC;locus_tag=Rv0631c;product=Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide);protein_id=CCP43372.1;transl_table=11
AL123456.3	EMBL	gene	728583	729278	.	-	.	ID=gene-Rv0632c;Name=echA3;gbkey=Gene;gene=echA3;gene_biotype=protein_coding;locus_tag=Rv0632c
AL123456.3	EMBL	CDS	728583	729278	.	-	0	ID=cds-CCP43373.1;Parent=gene-Rv0632c;Dbxref=EnsemblGenomes-Gn:Rv0632c,EnsemblGenomes-Tr:CCP43373,GOA:I6Y8B5,InterPro:IPR001753,InterPro:IPR029045,UniProtKB/TrEMBL:I6Y8B5,NCBI_GP:CCP43373.1;Name=CCP43373.1;Note=Rv0632c%2C (MTCY20H10.13c)%2C len: 231 aa. Probable echA3%2C enoyl-CoA hydratase%2C almost identical to the MTU88877_1 enoyl-CoA hydratase of Mycobacterium tuberculosis field isolate NTI64719%2C FASTA score: (92.4%25 identity in 184 aa overlap). Also similar to others e.g. P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa)%2C FASTA scores: opt: 206%2C E(): 6.3e-07%2C (31.5%25 identity in 232 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA3;locus_tag=Rv0632c;product=Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43373.1;transl_table=11
AL123456.3	EMBL	gene	729327	730166	.	-	.	ID=gene-Rv0633c;Name=Rv0633c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0633c
AL123456.3	EMBL	CDS	729327	730166	.	-	0	ID=cds-CCP43374.1;Parent=gene-Rv0633c;Dbxref=EnsemblGenomes-Gn:Rv0633c,EnsemblGenomes-Tr:CCP43374,UniProtKB/TrEMBL:P96923,NCBI_GP:CCP43374.1;Name=CCP43374.1;Note=Rv0633c%2C (MTCY20H11.14c)%2C len: 279 aa. Possible exported protein%3B has hydrophobic stretch at aa 23-41.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0633c;product=Possible exported protein;protein_id=CCP43374.1;transl_table=11
AL123456.3	EMBL	gene	730320	731033	.	-	.	ID=gene-Rv0634c;Name=Rv0634c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0634c
AL123456.3	EMBL	CDS	730320	731033	.	-	0	ID=cds-CCP43375.1;Parent=gene-Rv0634c;Dbxref=EnsemblGenomes-Gn:Rv0634c,EnsemblGenomes-Tr:CCP43375,GOA:I6Y4A5,InterPro:IPR001279,UniProtKB/TrEMBL:I6Y4A5,NCBI_GP:CCP43375.1;Name=CCP43375.1;Note=Rv0634c%2C (MTCY20H10.15c)%2C len: 237 aa. Possible glyoxalase II%2C equivalent to NP_302290.1|NC_002677 putative glyoxylase II from Mycobacterium leprae (238 aa)%3B and similar to U00011_3|Y0BK_MYCLE|Q49649 hypothetical 23.9 kDa protein from Mycobacterium leprae (218 aa)%2C FASTA scores: opt: 281%2C E(): 3.9e-12%2C (31.8%25 identity in 201 aa overlap). Also similar to other glyoxalases and metallo-beta-lactamase family proteins e.g. NP_386770.1|NC_003047 putative hydroxyacylglutathione hydrolase from Sinorhizobium meliloti (256 aa)%3B etc. Also similar to other putative glyoxylases from Mycobacterium tuberculosis e.g. Rv1637c. Belongs to the glyoxalase II family. Cofactor: binds two zinc ions.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0634c;product=Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II);protein_id=CCP43375.1;transl_table=11
AL123456.3	EMBL	gene	731113	731364	.	+	.	ID=gene-Rv0634A;Name=Rv0634A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0634A
AL123456.3	EMBL	CDS	731113	731364	.	+	0	ID=cds-CCP43376.1;Parent=gene-Rv0634A;Dbxref=EnsemblGenomes-Gn:Rv0634A,EnsemblGenomes-Tr:CCP43376,InterPro:IPR019239,NCBI_GP:CCP43376.1;Name=CCP43376.1;Note=Rv0634A%2C len: 83 aa. Unknown protein. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0634A;product=Unknown protein;protein_id=CCP43376.1;transl_table=11
AL123456.3	EMBL	gene	731494	731566	.	+	.	ID=gene-thrT;Name=thrT;gbkey=Gene;gene=thrT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	731494	731566	.	+	.	ID=rna-thrT;Parent=gene-thrT;Note=codon recognized: ACC%3B thrT%2C tRNA-Thr%2C anticodon ggt%2C length %3D 73;anticodon=(pos:731527..731529);gbkey=tRNA;gene=thrT;product=tRNA-Thr
AL123456.3	EMBL	exon	731494	731566	.	+	.	ID=exon-thrT-1;Parent=rna-thrT;Note=codon recognized: ACC%3B thrT%2C tRNA-Thr%2C anticodon ggt%2C length %3D 73;anticodon=(pos:731527..731529);gbkey=tRNA;gene=thrT;product=tRNA-Thr
AL123456.3	EMBL	gene	731603	731676	.	+	.	ID=gene-metT;Name=metT;gbkey=Gene;gene=metT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	731603	731676	.	+	.	ID=rna-metT;Parent=gene-metT;Note=codon recognized: AUG%3B metT%2C tRNA-Met%2C anticodon cat%2C length %3D 74;anticodon=(pos:731637..731639);gbkey=tRNA;gene=metT;product=tRNA-Met
AL123456.3	EMBL	exon	731603	731676	.	+	.	ID=exon-metT-1;Parent=rna-metT;Note=codon recognized: AUG%3B metT%2C tRNA-Met%2C anticodon cat%2C length %3D 74;anticodon=(pos:731637..731639);gbkey=tRNA;gene=metT;product=tRNA-Met
AL123456.3	EMBL	gene	731712	731879	.	+	.	ID=gene-Rv0634B;Name=rpmG2;gbkey=Gene;gene=rpmG2;gene_biotype=protein_coding;locus_tag=Rv0634B
AL123456.3	EMBL	CDS	731712	731879	.	+	0	ID=cds-CCP43377.1;Parent=gene-Rv0634B;Dbxref=EnsemblGenomes-Gn:Rv0634B,EnsemblGenomes-Tr:CCP43377,GOA:P9WH95,InterPro:IPR001705,InterPro:IPR011332,InterPro:IPR018264,NCBI_GP:CCP43377.1;Name=CCP43377.1;Note=Rv0634B%2C len: 55 aa. rpmG2%2C 50S ribosomal protein L33. Note that Mycobacterium tuberculosis has a second rpmG gene: P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1 putative 50S ribosomal protein L33 (55 aa)%2C FASTA scores: opt: 391%2CE(): 2.9e-25%2C (100.0%25 identity in 55 aa overlap). Belongs to the L33P family of ribosomal proteins.;gbkey=CDS;gene=rpmG2;locus_tag=Rv0634B;product=50S ribosomal protein L33 RpmG2;protein_id=CCP43377.1;transl_table=11
AL123456.3	EMBL	gene	731930	732406	.	+	.	ID=gene-Rv0635;Name=hadA;gbkey=Gene;gene=hadA;gene_biotype=protein_coding;locus_tag=Rv0635
AL123456.3	EMBL	CDS	731930	732406	.	+	0	ID=cds-CCP43378.1;Parent=gene-Rv0635;Dbxref=EnsemblGenomes-Gn:Rv0635,EnsemblGenomes-Tr:CCP43378,GOA:P9WFK1,InterPro:IPR016709,InterPro:IPR029069,NCBI_GP:CCP43378.1;Name=CCP43378.1;Note=Rv0635%2C (MTCY20H10.16)%2C len: 158 aa. HadA%2C(3R)-hydroxyacyl-ACP dehydratase subunit%2C equivalent to NP_302287.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (159 aa)%3B and highly similar to YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa)%2C FASTA scores: opt: 387%2C E(): 5.9e-21%2C (43.4%25 identity in 145 aa overlap). Also similar CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa). And highly similar to two hypothetical proteins from Mycobacterium tuberculosis: Rv0504c|YV31_MYCTU|Q11168 (166 aa)%2C FASTA scores: opt: 405%2CE(): 3.2e-22%2C (45.0%25 identity in 140 aa overlap)%3B and Rv0637|MTY20H10_19 (2 ORFs downstream) (166 aa)%2C FASTA score: (48.7%25 identity in 150 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hadA;locus_tag=Rv0635;product=(3R)-hydroxyacyl-ACP dehydratase subunit HadA;protein_id=CCP43378.1;transl_table=11
AL123456.3	EMBL	gene	732393	732821	.	+	.	ID=gene-Rv0636;Name=hadB;gbkey=Gene;gene=hadB;gene_biotype=protein_coding;locus_tag=Rv0636
AL123456.3	EMBL	CDS	732393	732821	.	+	0	ID=cds-CCP43379.1;Parent=gene-Rv0636;Dbxref=EnsemblGenomes-Gn:Rv0636,EnsemblGenomes-Tr:CCP43379,InterPro:IPR002539,InterPro:IPR029069,UniProtKB/TrEMBL:I6WYY7,NCBI_GP:CCP43379.1;Name=CCP43379.1;Note=Rv0636%2C (MTCY20H10.17)%2C len: 142 aa. HadB%2C(3R)-hydroxyacyl-ACP dehydratase subunit%2C equivalent to NP_302286.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (142 aa). Shows structural similarity to six others in Mycobacterium tuberculosis (see Castell et al (2005) below). Also highly similar to CAB77411.1|AL160431|SCD82.08 hypothetical protein from Streptomyces coelicolor (142 aa)%3B and similar to others e.g. U28943|CELE04F6_3 from Caenorhabditis elegans (cosmid E04) (298 aa)%2C FASTA scores: opt: 167%2C E(): 0.00064%2C (31.6 identity in 117 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hadB;locus_tag=Rv0636;product=(3R)-hydroxyacyl-ACP dehydratase subunit HadB;protein_id=CCP43379.1;transl_table=11
AL123456.3	EMBL	gene	732825	733325	.	+	.	ID=gene-Rv0637;Name=hadC;gbkey=Gene;gene=hadC;gene_biotype=protein_coding;locus_tag=Rv0637
AL123456.3	EMBL	CDS	732825	733325	.	+	0	ID=cds-CCP43380.1;Parent=gene-Rv0637;Dbxref=EnsemblGenomes-Gn:Rv0637,EnsemblGenomes-Tr:CCP43380,GOA:P9WFJ9,InterPro:IPR016709,InterPro:IPR029069,NCBI_GP:CCP43380.1;Name=CCP43380.1;Note=Rv0637%2C (MTCY20H10.18)%2C len: 166 aa. HadC%2C(3R)-hydroxyacyl-ACP dehydratase subunit%2C equivalent to NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae (166 aa)%2CFASTA scores: opt: 352%2C E(): 4e-19%2C (39.2%25 identity in 148 aa overlap)%3B and highly similar to others from Mycobacterium leprae e.g. NP_302287.1|NC_002677 conserved hypothetical protein (159 aa). Also highly similar to CAB77410.1|AL160431|SCD82.07 hypothetical protein from Streptomyces coelicolor (150 aa)%3B Rv0635|NP_215149.1|NC_000962|MTY20H10_17 conserved hypothetical protein (two ORFs upstream) from Mycobacterium tuberculosis (158 aa)%2C FASTA score: (49.3%25 identity in 150 aa overlap)%3B and Rv0504c|NP_215018.1|NC_000962|YV31_MYCTU|Q11168 hypothetical protein from Mycobacterium tuberculosis (166 aa)%2C FASTA scores: opt: 380%2C E(): 3.8e-21%2C (43.1%25 identity in 137 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hadC;locus_tag=Rv0637;product=(3R)-hydroxyacyl-ACP dehydratase subunit HadC;protein_id=CCP43380.1;transl_table=11
AL123456.3	EMBL	gene	733524	733596	.	+	.	ID=gene-trpT;Name=trpT;gbkey=Gene;gene=trpT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	733524	733596	.	+	.	ID=rna-trpT;Parent=gene-trpT;Note=codon recognized: UGG%3B trpT%2C tRNA-Trp%2C anticodon cca%2C length %3D 73;anticodon=(pos:733557..733559);gbkey=tRNA;gene=trpT;product=tRNA-Trp
AL123456.3	EMBL	exon	733524	733596	.	+	.	ID=exon-trpT-1;Parent=rna-trpT;Note=codon recognized: UGG%3B trpT%2C tRNA-Trp%2C anticodon cca%2C length %3D 73;anticodon=(pos:733557..733559);gbkey=tRNA;gene=trpT;product=tRNA-Trp
AL123456.3	EMBL	gene	733737	734222	.	+	.	ID=gene-Rv0638;Name=secE1;gbkey=Gene;gene=secE1;gene_biotype=protein_coding;gene_synonym=secE;locus_tag=Rv0638
AL123456.3	EMBL	CDS	733737	734222	.	+	0	ID=cds-CCP43381.1;Parent=gene-Rv0638;Dbxref=EnsemblGenomes-Gn:Rv0638,EnsemblGenomes-Tr:CCP43381,GOA:P9WGN7,InterPro:IPR001901,InterPro:IPR005807,InterPro:IPR022943,NCBI_GP:CCP43381.1;Name=CCP43381.1;Note=Rv0638%2C (MTCY20H10.19)%2C len: 161 aa. Probable secE1%2Cpreprotein translocase (tail-anchored membrane protein) (see citation below)%2C highly similar at C-terminal half to others e.g. P36690|SECE_STRGR preprotein translocase SECE subunit from Streptomyces griseus (86 aa)%2C FASTA scores: opt: 220%2C E(): 4.6e-06%2C (35.4%25 identity in 96 aa overlap)%3B P16920|SECE_ECOLI preprotein translocase sece subunit from Escherichia coli strains K12 and O157:H7 (127 aa)%2C FASTA scores: opt: 122%2C E(): 0.34%2C (37.0%25 identity in 54 aa overlap)%3B etc. Contains PS01067 Protein secE/sec61-gamma signature. Belongs to the SECE/SEC61-gamma family. Part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c%2C SECD|Rv2587c%2C SECE%2C SECF|Rv2586c%2CSECG|Rv1440 and SECY|Rv0732. Note that previously known as secE.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=secE1;inference=protein motif:PROSITE:PS01067;locus_tag=Rv0638;product=Probable preprotein translocase SecE1;protein_id=CCP43381.1;transl_table=11
AL123456.3	EMBL	gene	734254	734970	.	+	.	ID=gene-Rv0639;Name=nusG;gbkey=Gene;gene=nusG;gene_biotype=protein_coding;locus_tag=Rv0639
AL123456.3	EMBL	CDS	734254	734970	.	+	0	ID=cds-CCP43382.1;Parent=gene-Rv0639;Dbxref=EnsemblGenomes-Gn:Rv0639,EnsemblGenomes-Tr:CCP43382,GOA:P9WIU9,InterPro:IPR001062,InterPro:IPR005824,InterPro:IPR006645,InterPro:IPR008991,InterPro:IPR014722,InterPro:IPR015869,PDB:2MI6,NCBI_GP:CCP43382.1;Name=CCP43382.1;Note=Rv0639%2C (MTCY20H10.20)%2C len: 238 aa. Probable nusG%2Ctranscription antitermination protein%2C equivalent to NP_302283.1|NC_002677 transcription antitermination protein nusG from Mycobacterium leprae (228 aa). Also highly similar to others e.g. P36260|NUSG_STRGR from Streptomyces griseus (294 aa)%2C FASTA scores: opt: 845%2C E(): 0%2C (55.4%25 identity in 233 aa overlap)%3B etc. Note that shorter at the N-terminus than other nusG. Contains PS01014 Transcription termination factor nusG signature. Belongs to the NusG family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nusG;inference=protein motif:PROSITE:PS01014;locus_tag=Rv0639;product=Probable transcription antitermination protein NusG;protein_id=CCP43382.1;transl_table=11
AL123456.3	EMBL	gene	735022	735450	.	+	.	ID=gene-Rv0640;Name=rplK;gbkey=Gene;gene=rplK;gene_biotype=protein_coding;locus_tag=Rv0640
AL123456.3	EMBL	CDS	735022	735450	.	+	0	ID=cds-CCP43383.1;Parent=gene-Rv0640;Dbxref=EnsemblGenomes-Gn:Rv0640,EnsemblGenomes-Tr:CCP43383,GOA:P9WHE5,InterPro:IPR000911,InterPro:IPR006519,InterPro:IPR020783,InterPro:IPR020784,InterPro:IPR020785,NCBI_GP:CCP43383.1;Name=CCP43383.1;Note=Rv0640%2C (MTCY20H11.21)%2C len: 142 aa. rplK%2C 50S ribosomal protein L11%2C equivalent to NP_302282.1|NC_002677 50S ribosomal protein L11 from Mycobacterium leprae (142 aa). Also highly similar to others e.g. P48954|RL11_STRCO|SCD82.19 50s ribosomal protein L11 from Streptomyces coelicolor (144 aa)%2C FASTA scores: opt: 763%2CE(): 0%2C (84.6%25 identity in 143 aa overlap)%3B etc. Contains PS00359 Ribosomal protein L11 signature. Belongs to the L11P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplK;inference=protein motif:PROSITE:PS00359;locus_tag=Rv0640;product=50S ribosomal protein L11 RplK;protein_id=CCP43383.1;transl_table=11
AL123456.3	EMBL	gene	735517	736224	.	+	.	ID=gene-Rv0641;Name=rplA;gbkey=Gene;gene=rplA;gene_biotype=protein_coding;locus_tag=Rv0641
AL123456.3	EMBL	CDS	735517	736224	.	+	0	ID=cds-CCP43384.1;Parent=gene-Rv0641;Dbxref=EnsemblGenomes-Gn:Rv0641,EnsemblGenomes-Tr:CCP43384,GOA:P9WHC7,InterPro:IPR002143,InterPro:IPR005878,InterPro:IPR016094,InterPro:IPR016095,InterPro:IPR023673,InterPro:IPR023674,InterPro:IPR028364,NCBI_GP:CCP43384.1;Name=CCP43384.1;Note=Rv0641%2C (MTCY20H10.22)%2C len: 235 aa. rplA%2C 50S ribosomal protein L1%2C equivalent to NP_302281.1|NC_002677 50S ribosomal protein L1 from Mycobacterium leprae (235 aa). Also highly similar to others e.g. P3625|RL1_STRGR 50s ribosomal protein L1 from Streptomyces griseus (240 aa)%2CFASTA scores: opt: 1081%2C E(): 0%2C (72.2%25 identity in 230 aa overlap)%3B etc. Belongs to the L1P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplA;locus_tag=Rv0641;product=50S ribosomal protein L1 RplA;protein_id=CCP43384.1;transl_table=11
AL123456.3	EMBL	gene	736298	737203	.	-	.	ID=gene-Rv0642c;Name=mmaA4;gbkey=Gene;gene=mmaA4;gene_biotype=protein_coding;locus_tag=Rv0642c
AL123456.3	EMBL	CDS	736298	737203	.	-	0	ID=cds-CCP43385.1;Parent=gene-Rv0642c;Dbxref=EnsemblGenomes-Gn:Rv0642c,EnsemblGenomes-Tr:CCP43385,GOA:Q79FX8,InterPro:IPR003333,InterPro:IPR029063,PDB:2FK7,PDB:2FK8,PDB:3HA3,PDB:3HA5,PDB:3HA7,NCBI_GP:CCP43385.1;Name=CCP43385.1;Note=Rv0642c%2C (MTCY20H10.23c)%2C len: 301 aa. MmaA4%2Cmethoxy mycolic acid synthase 4 (methyltransferase) (see citations below). Equivalent to AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (298 aa)%3B NP_302280.1|NC_002677 methyl mycolic acid synthase 4 from Mycobacterium leprae (298 aa)%3B and highly similar to others from Mycobacteria e.g. downstream ORF P72027|mmaA3|Rv0643c|MTCY20H10.24c putative methoxy mycolic acid synthase 3 from Mycobacterium tuberculosis (293 aa). Phosphorylated in vitro by PknJ|Rv2088 (See Jang et al.%2C2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmaA4;locus_tag=Rv0642c;product=Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase);protein_id=CCP43385.1;transl_table=11
AL123456.3	EMBL	gene	737268	738149	.	-	.	ID=gene-Rv0643c;Name=mmaA3;gbkey=Gene;gene=mmaA3;gene_biotype=protein_coding;locus_tag=Rv0643c
AL123456.3	EMBL	CDS	737268	738149	.	-	0	ID=cds-CCP43386.1;Parent=gene-Rv0643c;Dbxref=EnsemblGenomes-Gn:Rv0643c,EnsemblGenomes-Tr:CCP43386,GOA:P0CH91,InterPro:IPR003333,InterPro:IPR029063,NCBI_GP:CCP43386.1;Name=CCP43386.1;Note=Rv0643c%2C (MTCY20H10.24c)%2C len: 293 aa. MmaA3%2Cmethoxy mycolic acid synthase 3 (methyltransferase) (see citations below). Equivalent to AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (289 aa)%3B and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy mycolic acid synthase 4 from Mycobacterium tuberculosis (301 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmaA3;locus_tag=Rv0643c;product=Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase);protein_id=CCP43386.1;transl_table=11
AL123456.3	EMBL	gene	738297	739160	.	-	.	ID=gene-Rv0644c;Name=mmaA2;gbkey=Gene;gene=mmaA2;gene_biotype=protein_coding;locus_tag=Rv0644c
AL123456.3	EMBL	CDS	738297	739160	.	-	0	ID=cds-CCP43387.1;Parent=gene-Rv0644c;Dbxref=EnsemblGenomes-Gn:Rv0644c,EnsemblGenomes-Tr:CCP43387,GOA:Q79FX6,InterPro:IPR003333,InterPro:IPR029063,PDB:1TPY,NCBI_GP:CCP43387.1;Name=CCP43387.1;Note=Rv0644c%2C (MTCY20H10.25c)%2C len: 287 aa. MmaA2%2Cmethoxy mycolic acid synthase 2 (methyltransferase) (see citations below). Equivalent to AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid modification protein) from Mycobacterium bovis BCG strain Pasteur (287 aa)%3B and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy mycolic acid synthase 4 from Mycobacterium tuberculosis (301 aa). Note that alternative start is at position 739247.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmaA2;locus_tag=Rv0644c;product=Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase);protein_id=CCP43387.1;transl_table=11
AL123456.3	EMBL	gene	739327	740187	.	-	.	ID=gene-Rv0645c;Name=mmaA1;gbkey=Gene;gene=mmaA1;gene_biotype=protein_coding;locus_tag=Rv0645c
AL123456.3	EMBL	CDS	739327	740187	.	-	0	ID=cds-CCP43388.1;Parent=gene-Rv0645c;Dbxref=EnsemblGenomes-Gn:Rv0645c,EnsemblGenomes-Tr:CCP43388,GOA:P9WPB1,InterPro:IPR003333,InterPro:IPR029063,NCBI_GP:CCP43388.1;Name=CCP43388.1;Note=Rv0645c%2C (MTCY20H10.26c)%2C len: 286 aa. MmaA1%2Cmethoxy mycolic acid synthase 1 (methyltransferase) (see citations below). Equivalent to NP_302279.1|NC_002677 methyl mycolic acid synthase 1 from Mycobacterium leprae (286 aa)%3B and highly similar to others from Mycobacteria e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy mycolic acid synthase 4 from Mycobacterium tuberculosis (301 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmaA1;locus_tag=Rv0645c;product=Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase);protein_id=CCP43388.1;transl_table=11
AL123456.3	EMBL	gene	740234	741139	.	-	.	ID=gene-Rv0646c;Name=lipG;gbkey=Gene;gene=lipG;gene_biotype=protein_coding;locus_tag=Rv0646c
AL123456.3	EMBL	CDS	740234	741139	.	-	0	ID=cds-CCP43389.1;Parent=gene-Rv0646c;Dbxref=EnsemblGenomes-Gn:Rv0646c,EnsemblGenomes-Tr:CCP43389,GOA:P96935,InterPro:IPR029058,UniProtKB/TrEMBL:P96935,NCBI_GP:CCP43389.1;Name=CCP43389.1;Note=Rv0646c%2C (MTCY20H10.27c)%2C len: 301 aa. Probable lipG%2C lipase/esterase%2C equivalent to NP_302278.1|NC_002677 probable hydrolase from Mycobacterium leprae (304 aa). Also highly similar to various hydrolases%2C especially lipases e.g. AA61351.1|X88895 carboxyl esterase from Acinetobacter calcoaceticus (312 aa)%2C FASTA scores: opt: 867%2C E(): 0%2C(50.2%25 identity in 279 aa overlap)%3B etc. Also similar to transferases e.g. P77026 macrolide 2'-phosphotransferase II from Escherichia coli (279 aa)%2C FASTA scores: E(): 1.3e-14%2C(32.5%25 identity in 286 aa overlap). Similar to M. tuberculosis non-heme bromoperoxidases and epoxide hydrolases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipG;locus_tag=Rv0646c;product=Probable lipase/esterase LipG;protein_id=CCP43389.1;transl_table=11
AL123456.3	EMBL	gene	741151	742617	.	-	.	ID=gene-Rv0647c;Name=Rv0647c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0647c
AL123456.3	EMBL	CDS	741151	742617	.	-	0	ID=cds-CCP43390.1;Parent=gene-Rv0647c;Dbxref=EnsemblGenomes-Gn:Rv0647c,EnsemblGenomes-Tr:CCP43390,GOA:P9WQI1,InterPro:IPR000719,InterPro:IPR004147,InterPro:IPR011009,NCBI_GP:CCP43390.1;Name=CCP43390.1;Note=Rv0647c%2C (MTCY20H10.28c)%2C len: 488 aa. Conserved protein%2C equivalent to NP_302277.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (448 aa). Also showing similarity to a variety of hypothetical ABC1-like proteins or conserved hypothetical proteins e.g. D90908_28|P73627 ABC1-like protein from Synechocystis (585 aa)%2C FASTA scores: E(): 1.8e-31%2C (29.1%25 identity in 474 aa overlap)%3B Q55884 HYPOTHETICAL6 5.0 KD protein (567 aa)%2CFASTA scores: opt: 583%2C E(): 5.7e-30%2C (28.1%25 identity in 416 aa overlap)%3B etc. Also similar to Rv3197 conserved hypothetical protein from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0647c;product=Conserved protein;protein_id=CCP43390.1;transl_table=11
AL123456.3	EMBL	gene	742719	746366	.	+	.	ID=gene-Rv0648;Name=Rv0648;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0648
AL123456.3	EMBL	CDS	742719	746366	.	+	0	ID=cds-CCP43391.1;Parent=gene-Rv0648;Dbxref=EnsemblGenomes-Gn:Rv0648,EnsemblGenomes-Tr:CCP43391,GOA:P96937,InterPro:IPR000602,InterPro:IPR011013,InterPro:IPR011330,InterPro:IPR011682,InterPro:IPR013780,InterPro:IPR013783,InterPro:IPR015341,InterPro:IPR018905,InterPro:IPR027291,InterPro:IPR028995,UniProtKB/TrEMBL:P96937,NCBI_GP:CCP43391.1;Name=CCP43391.1;Note=Rv0648%2C (MTCY20H10.29)%2C len: 1215 aa. Alpha-mannosidase (see citation below)%2C showing some similarity to hypothetical proteins and various sugar hydrolases e.g. SYCSLRA_6|Q55528 hypothetical 1 20.4 kDa protein from Synechocystis (1042 aa)%2C FASTA scores: opt: 260%2C E(): 3.6e-08%2C (23.4%25 identity in 602 aa overlap)%3B etc. Contains PS00659 Glycosyl hydrolases family 5 signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00659;locus_tag=Rv0648;product=Alpha-mannosidase;protein_id=CCP43391.1;transl_table=11
AL123456.3	EMBL	gene	746363	747037	.	+	.	ID=gene-Rv0649;Name=fabD2;gbkey=Gene;gene=fabD2;gene_biotype=protein_coding;locus_tag=Rv0649
AL123456.3	EMBL	CDS	746363	747037	.	+	0	ID=cds-CCP43392.1;Parent=gene-Rv0649;Dbxref=EnsemblGenomes-Gn:Rv0649,EnsemblGenomes-Tr:CCP43392,GOA:Q79FX5,InterPro:IPR027304,UniProtKB/TrEMBL:Q79FX5,NCBI_GP:CCP43392.1;Name=CCP43392.1;Note=Rv0649%2C (MTCY20H10.30)%2C len: 224 aa. Possible fabD2%2Cmalonyl CoA-acyl carrier protein transacylase%2C similar to mtfabd|FABD_MYCTU|Q10501|Rv2243 malonyl CoA-acyl carrier protein transacylase from Mycobacterium tuberculosis (302 aa)%2C FASTA scores: opt: 133%2C E(): 0.074%2C (31.3%25 identity in 147 aa overlap).;gbkey=CDS;gene=fabD2;locus_tag=Rv0649;product=Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT);protein_id=CCP43392.1;transl_table=11
AL123456.3	EMBL	gene	747037	747945	.	+	.	ID=gene-Rv0650;Name=Rv0650;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0650
AL123456.3	EMBL	CDS	747037	747945	.	+	0	ID=cds-CCP43393.1;Parent=gene-Rv0650;Dbxref=EnsemblGenomes-Gn:Rv0650,EnsemblGenomes-Tr:CCP43393,GOA:I6Y8D3,InterPro:IPR000600,UniProtKB/TrEMBL:I6Y8D3,NCBI_GP:CCP43393.1;Name=CCP43393.1;Note=Rv0650%2C (MTCY20H10.31)%2C len: 302 aa. Possible sugar kinase%2C highly similar to others e.g. CAB95296.1|AL359779 putative sugar kinase from Streptomyces coelicolor (317 aa)%3B NP_406512.1|NC_003143 putative sugar kinase from Yersinia pestis (290 aa)%3B NP_229269.1|NC_000853 glucokinase from Thermotoga maritima (317 aa)%3B etc.Contains PS01125 ROK family signature. Belongs to the ROK (NAGC/XYLR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01125;locus_tag=Rv0650;product=Possible sugar kinase;protein_id=CCP43393.1;transl_table=11
AL123456.3	EMBL	gene	748276	748812	.	+	.	ID=gene-Rv0651;Name=rplJ;gbkey=Gene;gene=rplJ;gene_biotype=protein_coding;locus_tag=Rv0651
AL123456.3	EMBL	CDS	748276	748812	.	+	0	ID=cds-CCP43394.1;Parent=gene-Rv0651;Dbxref=EnsemblGenomes-Gn:Rv0651,EnsemblGenomes-Tr:CCP43394,GOA:P9WHE7,InterPro:IPR001790,InterPro:IPR002363,InterPro:IPR022973,NCBI_GP:CCP43394.1;Name=CCP43394.1;Note=Rv0651%2C (MTCY20H10.32)%2C len: 178 aa. rplJ%2C 50S ribosomal protein L10%2C equivalent to NP_302276.1|NC_002677 50S ribosomal protein L10 from Mycobacterium leprae (177 aa). Also highly similar to others e.g. P36257|RL10_STRGR 50s ribosomal protein L10 from Streptomyces griseus (185 aa)%2C FASTA scores: opt: 633%2C E(): 0%2C (59.0 %25 identity in 173 aa overlap)%3B etc. Belongs to the L10P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplJ;locus_tag=Rv0651;product=50S ribosomal protein L10 RplJ;protein_id=CCP43394.1;transl_table=11
AL123456.3	EMBL	gene	748849	749241	.	+	.	ID=gene-Rv0652;Name=rplL;gbkey=Gene;gene=rplL;gene_biotype=protein_coding;gene_synonym=L7|L12;locus_tag=Rv0652
AL123456.3	EMBL	CDS	748849	749241	.	+	0	ID=cds-CCP43395.1;Parent=gene-Rv0652;Dbxref=EnsemblGenomes-Gn:Rv0652,EnsemblGenomes-Tr:CCP43395,GOA:P9WHE3,InterPro:IPR000206,InterPro:IPR008932,InterPro:IPR013823,InterPro:IPR014719,NCBI_GP:CCP43395.1;Name=CCP43395.1;Note=Rv0652%2C (MTCY20H10.33)%2C len: 130 aa. rplL (alternate gene name: L7|L12)%2C 50S ribosomal protein L7/L12%2Cequivalent to NP_302275.1|NC_002677 50S ribosomal protein L7/L12 from Mycobacterium leprae (130 aa)%3B and P37381|RL7_MYCBO 50s ribosomal protein L7/L12 from Mycobacterium bovis (130 aa). Also highly similar to others e.g. P02396|RL7_STRGR 50S ribosomal protein L7/L12 from Streptomyces griseus (127 aa)%3B etc. Belongs to the L12P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplL;locus_tag=Rv0652;product=50S ribosomal protein L7/L12 RplL (SA1);protein_id=CCP43395.1;transl_table=11
AL123456.3	EMBL	gene	749234	749929	.	-	.	ID=gene-Rv0653c;Name=Rv0653c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0653c
AL123456.3	EMBL	CDS	749234	749929	.	-	0	ID=cds-CCP43396.1;Parent=gene-Rv0653c;Dbxref=EnsemblGenomes-Gn:Rv0653c,EnsemblGenomes-Tr:CCP43396,GOA:P96941,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR025996,UniProtKB/TrEMBL:P96941,NCBI_GP:CCP43396.1;Name=CCP43396.1;Note=Rv0653c%2C (MTCI376.23%2C MTCY20H10.34c)%2C len: 231 aa. Possible transcriptional regulator%2C TetR family%2C similar in N-terminus to others e.g. CAC03642.1|AL391338 putative TetR-family transcriptional regulator from Streptomyces coelicolor (190 aa)%3B Q51597 cam repressor from Pseudomonas putida (186 aa)%2C FASTA scores: opt: 150%2C E(): 0.00085%2C(27.8%25 identity in 97 aa overlap)%3B etc. Also some similarity to Mycobacterium tuberculosis hypothetical transcriptional regulators Rv0681 and Rv1816. Contains probable helix-turn helix motif from aa 27-48 (Score 1156%2C+3.12 SD).;gbkey=CDS;locus_tag=Rv0653c;product=Possible transcriptional regulatory protein (probably TetR-family);protein_id=CCP43396.1;transl_table=11
AL123456.3	EMBL	gene	750000	751505	.	+	.	ID=gene-Rv0654;Name=Rv0654;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0654
AL123456.3	EMBL	CDS	750000	751505	.	+	0	ID=cds-CCP43397.1;Parent=gene-Rv0654;Dbxref=EnsemblGenomes-Gn:Rv0654,EnsemblGenomes-Tr:CCP43397,GOA:P9WPR5,InterPro:IPR004294,NCBI_GP:CCP43397.1;Name=CCP43397.1;Note=Rv0654%2C (MTCI376.22)%2C len: 501 aa. Probable dioxygenase%2C highly similar to others eg AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase (involved in tetraene formation) from Streptomyces antibioticus (456 aa)%3B CAB56138.1| AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa)%3B T51734 neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid dioxygenase) from Arabidopsis thaliana (538 aa)%3B Q53353 lignostilbene-alpha%2Cbeta-dioxygenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis)%2C FASTA scores: opt: 280%2C E(): 2.3e-11%2C (28.5%25 identity in 523 aa overlap)%3B etc. Also some similarity with Rv0913c|MTCY21C12.07c possible dioxygenase from Mycobacterium tuberculosis (501 aa)%2C FASTA score: (29.5%25 identity in 522 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0654;product=Probable dioxygenase;protein_id=CCP43397.1;transl_table=11
AL123456.3	EMBL	gene	751517	752596	.	+	.	ID=gene-Rv0655;Name=mkl;gbkey=Gene;gene=mkl;gene_biotype=protein_coding;locus_tag=Rv0655
AL123456.3	EMBL	CDS	751517	752596	.	+	0	ID=cds-CCP43398.1;Parent=gene-Rv0655;Dbxref=EnsemblGenomes-Gn:Rv0655,EnsemblGenomes-Tr:CCP43398,GOA:P9WQL5,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP43398.1;Name=CCP43398.1;Note=Rv0655%2C (MTCI376.21)%2C len: 359 aa. Possible mkl%2Cribonucleotide-transport ATP-binding protein ABC transporter (see Braibant et al.%2C 2000)%2C equivalent to P30769|MKL_MYCLE|ML1892 possible ribonucleotide transport ATP-binding protein from Mycobacterium leprae (347 aa)%2CFASTA scores: opt: 2021%2C E(): 0%2C (92.2%25 identity in 335 aa overlap). Also highly similar to many e.g. AB92896.1|AL356992 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (343 aa)%3B NP_253146.1|NC_002516 probable ATP-binding component of ABC transporter from Pseudomonas aeruginosa (269 aa)%3B P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding protein from Escherichia coli (269 aa)%2C FASTA scores: opt: 644%2C E(): 3.4e-33%2C (38.5%25 identity in 244 aa overlap)%3B etc. Also similar to many other Mycobacterium tuberculosis ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351 aa)%2CFASTA score: (33.6%25 identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mkl;inference=protein motif:PROSITE:PS00211;locus_tag=Rv0655;product=Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl;protein_id=CCP43398.1;transl_table=11
AL123456.3	EMBL	gene	752984	753367	.	-	.	ID=gene-Rv0656c;Name=vapC6;gbkey=Gene;gene=vapC6;gene_biotype=protein_coding;locus_tag=Rv0656c
AL123456.3	EMBL	CDS	752984	753367	.	-	0	ID=cds-CCP43399.1;Parent=gene-Rv0656c;Dbxref=EnsemblGenomes-Gn:Rv0656c,EnsemblGenomes-Tr:CCP43399,GOA:P9WFB5,InterPro:IPR002716,InterPro:IPR022907,NCBI_GP:CCP43399.1;Name=CCP43399.1;Note=Rv0656c%2C (MTCI376.20)%2C len: 127 aa. Possible vapC6%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0657c%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to other proteins from Mycobacterium tuberculosis e.g. Rv2757c%2C Rv2546%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=vapC6;locus_tag=Rv0656c;product=Possible toxin VapC6;protein_id=CCP43399.1;transl_table=11
AL123456.3	EMBL	gene	753462	753617	.	-	.	ID=gene-Rv0657c;Name=vapB6;gbkey=Gene;gene=vapB6;gene_biotype=protein_coding;locus_tag=Rv0657c
AL123456.3	EMBL	CDS	753462	753617	.	-	0	ID=cds-CCP43400.1;Parent=gene-Rv0657c;Dbxref=EnsemblGenomes-Gn:Rv0657c,EnsemblGenomes-Tr:CCP43400,InterPro:IPR019239,NCBI_GP:CCP43400.1;Name=CCP43400.1;Note=Rv0657c%2C (MTCI376.19)%2C len: 51 aa. Possible vapB6%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0656c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similarity with others from Mycobacterium tuberculosis e.g. Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa)%2C FASTA scores: opt: 107%2C E(): 0.0038%2C (45.8%25 identity in 48 aa overlap)%2C Rv2871%2C Rv1560%2C etc. Also some similarity with AL020958|SC4H8_7 from Streptomyces coelicolor (66 aa)%2CFASTA score: (41.0%25 identity in 39 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=vapB6;locus_tag=Rv0657c;product=Possible antitoxin VapB6;protein_id=CCP43400.1;transl_table=11
AL123456.3	EMBL	gene	753693	754409	.	-	.	ID=gene-Rv0658c;Name=Rv0658c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0658c
AL123456.3	EMBL	CDS	753693	754409	.	-	0	ID=cds-CCP43401.1;Parent=gene-Rv0658c;Dbxref=EnsemblGenomes-Gn:Rv0658c,EnsemblGenomes-Tr:CCP43401,GOA:O06781,InterPro:IPR003675,UniProtKB/TrEMBL:O06781,NCBI_GP:CCP43401.1;Name=CCP43401.1;Note=Rv0658c%2C (MTCI376.18)%2C len: 238 aa. Probable conserved integral membrane protein%2C equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below)%2C and showing some similarity with P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from Escherichia coli (217 aa)%2C FASTA scores: opt: 174%2C E(): 5.3e-05%2C (25.6%25 identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0658c;product=Probable conserved integral membrane protein;protein_id=CCP43401.1;transl_table=11
AL123456.3	EMBL	gene	754685	754993	.	-	.	ID=gene-Rv0659c;Name=mazF2;gbkey=Gene;gene=mazF2;gene_biotype=protein_coding;gene_synonym=mt4;locus_tag=Rv0659c
AL123456.3	EMBL	CDS	754685	754993	.	-	0	ID=cds-CCP43402.1;Parent=gene-Rv0659c;Dbxref=EnsemblGenomes-Gn:Rv0659c,EnsemblGenomes-Tr:CCP43402,GOA:P9WII1,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP43402.1;Name=CCP43402.1;Note=Rv0659c%2C (MTCI376.17)%2C len: 102 aa. MazF2%2C toxin%2Cpart of toxin-antitoxin (TA) operon with Rv0660c (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%2C weakly similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv1942c%2C Rv1495%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=mazF2;locus_tag=Rv0659c;product=Toxin MazF2;protein_id=CCP43402.1;transl_table=11
AL123456.3	EMBL	gene	754980	755225	.	-	.	ID=gene-Rv0660c;Name=mazE2;gbkey=Gene;gene=mazE2;gene_biotype=protein_coding;locus_tag=Rv0660c
AL123456.3	EMBL	CDS	754980	755225	.	-	0	ID=cds-CCP43403.1;Parent=gene-Rv0660c;Dbxref=EnsemblGenomes-Gn:Rv0660c,EnsemblGenomes-Tr:CCP43403,NCBI_GP:CCP43403.1;Name=CCP43403.1;Note=Rv0660c%2C (MTCI376.16)%2C len: 81 aa. Possible mazE2%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0659c (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%2C showing some similarity to AF016485_130 from Halobacterium sp (100 aa)%2C FASTA scores: (32.4%25 identity in 74 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=mazE2;locus_tag=Rv0660c;product=Possible antitoxin MazE2;protein_id=CCP43403.1;transl_table=11
AL123456.3	EMBL	gene	755335	755772	.	-	.	ID=gene-Rv0661c;Name=vapC7;gbkey=Gene;gene=vapC7;gene_biotype=protein_coding;locus_tag=Rv0661c
AL123456.3	EMBL	CDS	755335	755772	.	-	0	ID=cds-CCP43404.1;Parent=gene-Rv0661c;Dbxref=EnsemblGenomes-Gn:Rv0661c,EnsemblGenomes-Tr:CCP43404,GOA:P9WFB3,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43404.1;Name=CCP43404.1;Note=Rv0661c%2C (MTCI376.15)%2C len: 145 aa. Possible vapC7%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0662c%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Rv2863|MTV003.09|MTV003_7 (126 aa)%2C FASTA scores: E(): 0.00087%2C (30.4%25 identity in 125 aa overlap)%2CRv0749|MTV041.23 (163 aa)%3B Rv0277c%2C Rv2530c%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=vapC7;locus_tag=Rv0661c;product=Possible toxin VapC7;protein_id=CCP43404.1;transl_table=11
AL123456.3	EMBL	gene	755769	756023	.	-	.	ID=gene-Rv0662c;Name=vapB7;gbkey=Gene;gene=vapB7;gene_biotype=protein_coding;locus_tag=Rv0662c
AL123456.3	EMBL	CDS	755769	756023	.	-	0	ID=cds-CCP43405.1;Parent=gene-Rv0662c;Dbxref=EnsemblGenomes-Gn:Rv0662c,EnsemblGenomes-Tr:CCP43405,GOA:O06777,NCBI_GP:CCP43405.1;Name=CCP43405.1;Note=Rv0662c%2C (MTCI376.14)%2C len: 84 aa. Possible vapB7%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0661c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similarity with others from Mycobacterium tuberculosis e.g. Rv2871%2C Rv1241%2C Rv2550c%2C etc. Start changed since first submission%2C now 38 aa shorter. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB7;locus_tag=Rv0662c;product=Possible antitoxin VapB7;protein_id=CCP43405.1;transl_table=11
AL123456.3	EMBL	gene	756137	758500	.	+	.	ID=gene-Rv0663;Name=atsD;gbkey=Gene;gene=atsD;gene_biotype=protein_coding;locus_tag=Rv0663
AL123456.3	EMBL	CDS	756137	758500	.	+	0	ID=cds-CCP43406.1;Parent=gene-Rv0663;Dbxref=EnsemblGenomes-Gn:Rv0663,EnsemblGenomes-Tr:CCP43406,GOA:I6XVW9,InterPro:IPR000917,InterPro:IPR013320,InterPro:IPR017849,InterPro:IPR017850,InterPro:IPR024607,UniProtKB/TrEMBL:I6XVW9,NCBI_GP:CCP43406.1;Name=CCP43406.1;Note=Rv0663%2C (MTCI376.13c)%2C len: 787 aa. Possible atsD%2Carylsulfatase%2C similar to others e.g. P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa)%2C FASTA scores: opt: 653%2C E(): 0%2C (33.1%25 identity in 544 aa overlap)%3B etc. Also similar to P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from Mycobacterium tuberculosis (787 aa)%2C FASTA score: (38.9%25 identity in 769 aa overlap)%3B and other arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa)%2C Rv0711%2C etc. Contains PS00523 Sulfatases signature 1. Belongs to the sulfatase family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atsD;inference=protein motif:PROSITE:PS00523;locus_tag=Rv0663;product=Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase);protein_id=CCP43406.1;transl_table=11
AL123456.3	EMBL	gene	758532	758804	.	+	.	ID=gene-Rv0664;Name=vapB8;gbkey=Gene;gene=vapB8;gene_biotype=protein_coding;locus_tag=Rv0664
AL123456.3	EMBL	CDS	758532	758804	.	+	0	ID=cds-CCP43407.1;Parent=gene-Rv0664;Dbxref=EnsemblGenomes-Gn:Rv0664,EnsemblGenomes-Tr:CCP43407,NCBI_GP:CCP43407.1;Name=CCP43407.1;Note=Rv0664%2C (MTCI376.12c)%2C len: 90 aa. Possible vapB8%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0665 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=vapB8;locus_tag=Rv0664;product=Possible antitoxin VapB8;protein_id=CCP43407.1;transl_table=11
AL123456.3	EMBL	gene	758801	759139	.	+	.	ID=gene-Rv0665;Name=vapC8;gbkey=Gene;gene=vapC8;gene_biotype=protein_coding;locus_tag=Rv0665
AL123456.3	EMBL	CDS	758801	759139	.	+	0	ID=cds-CCP43408.1;Parent=gene-Rv0665;Dbxref=EnsemblGenomes-Gn:Rv0665,EnsemblGenomes-Tr:CCP43408,GOA:P9WFB1,InterPro:IPR002716,InterPro:IPR029060,NCBI_GP:CCP43408.1;Name=CCP43408.1;Note=Rv0665%2C (MTCI376.11c)%2C len: 112 aa. Possible vapC8%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0664%2Ccontains PIN domain (See Arcus et al. 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Rv0627 (135 aa)%2C and Rv0595c. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=vapC8;locus_tag=Rv0665;product=Possible toxin VapC8;protein_id=CCP43408.1;transl_table=11
AL123456.3	EMBL	gene	759136	759309	.	+	.	ID=gene-Rv0666;Name=Rv0666;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0666
AL123456.3	EMBL	CDS	759136	759309	.	+	0	ID=cds-CCP43409.1;Parent=gene-Rv0666;Dbxref=EnsemblGenomes-Gn:Rv0666,EnsemblGenomes-Tr:CCP43409,GOA:O06773,UniProtKB/TrEMBL:O06773,NCBI_GP:CCP43409.1;Name=CCP43409.1;Note=Rv0666%2C (MTCI376.10c)%2C len: 57 aa. Possible membrane protein%3B has hydrophobic stretch at aa 29-47. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0666;product=Possible membrane protein;protein_id=CCP43409.1;transl_table=11
AL123456.3	EMBL	gene	759807	763325	.	+	.	ID=gene-Rv0667;Name=rpoB;gbkey=Gene;gene=rpoB;gene_biotype=protein_coding;locus_tag=Rv0667
AL123456.3	EMBL	CDS	759807	763325	.	+	0	ID=cds-CCP43410.1;Parent=gene-Rv0667;Dbxref=EnsemblGenomes-Gn:Rv0667,EnsemblGenomes-Tr:CCP43410,GOA:P9WGY9,InterPro:IPR007120,InterPro:IPR007121,InterPro:IPR007641,InterPro:IPR007642,InterPro:IPR007644,InterPro:IPR007645,InterPro:IPR010243,InterPro:IPR014724,InterPro:IPR015712,InterPro:IPR019462,PDB:4KBJ,PDB:4KBM,NCBI_GP:CCP43410.1;Name=CCP43410.1;Note=Rv0667%2C (MTCI376.08c)%2C len: 1172 aa. RpoB%2CDNA-directed RNA polymerase%2C beta chain (see Miller et al.%2C1994%3B Ahmad et al.%2C 2000)%2C equivalent to P30760|RPOB_MYCLE|ML1891 DNA-directed RNA polymerase beta chain from Mycobacterium leprae (1178 aa). Also highly similar to others e.g. AAF60349.1|AF242549_1|AF242549 DNA-dependent RNA polymerase beta subunit from Amycolatopsis mediterranei (1167 aa)%3B CAB77428.1|AL160431 DNA-directed RNA polymerase beta chain from Streptomyces coelicolor (1161 aa)%3B etc. Start site chosen on basis of RBS but alternative start exists at position 14359. Belongs to the RNA polymerase beta chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpoB;locus_tag=Rv0667;product=DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit);protein_id=CCP43410.1;transl_table=11
AL123456.3	EMBL	gene	763370	767320	.	+	.	ID=gene-Rv0668;Name=rpoC;gbkey=Gene;gene=rpoC;gene_biotype=protein_coding;locus_tag=Rv0668
AL123456.3	EMBL	CDS	763370	767320	.	+	0	ID=cds-CCP43411.1;Parent=gene-Rv0668;Dbxref=EnsemblGenomes-Gn:Rv0668,EnsemblGenomes-Tr:CCP43411,GOA:P9WGY7,InterPro:IPR000722,InterPro:IPR006592,InterPro:IPR007066,InterPro:IPR007080,InterPro:IPR007081,InterPro:IPR007083,InterPro:IPR012754,NCBI_GP:CCP43411.1;Name=CCP43411.1;Note=Rv0668%2C (MTCI376.07c)%2C len: 1316 aa. RpoC%2CDNA-directed RNA polymerase%2C beta' chain (see Miller et al.%2C 1994)%2C equivalent to P30761|RPOC_MYCLE|ML1890|S31146 DNA-directed RNA polymerase beta' chain from Mycobacterium leprae (1316 aa)%2C FASTA scores: opt: 8295%2C E(): 0%2C (95.6%25 identity in 1316 aa overlap). Also highly similar to others e.g. CAB77429.1|AL160431 DNA-directed RNA polymerase beta' chain (fragment) from Streptomyces coelicolor (1059 aa)%3B P37871|RPOC_BACSU from Bacillus subtilis (1199 aa)%2C FASTA scores: opt: 2367%2C E(): 0%2C (52.9 identity in 1317 aa overlap)%3B etc. Belongs to the RNA polymerase beta' chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpoC;locus_tag=Rv0668;product=DNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit).;protein_id=CCP43411.1;transl_table=11
AL123456.3	EMBL	gene	767684	769597	.	-	.	ID=gene-Rv0669c;Name=Rv0669c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0669c
AL123456.3	EMBL	CDS	767684	769597	.	-	0	ID=cds-CCP43412.1;Parent=gene-Rv0669c;Dbxref=EnsemblGenomes-Gn:Rv0669c,EnsemblGenomes-Tr:CCP43412,GOA:O06769,InterPro:IPR006823,NCBI_GP:CCP43412.1;Name=CCP43412.1;Note=Rv0669c%2C (MTCI376.05)%2C len: 637 aa. Possible hydrolase%2C highly similar to various hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 alkaline ceramidase from Pseudomonas aeruginosa (670 aa%2C) FASTA scores: opt: 1490%2CE(): 0%2C (41.2%25 identity in 651 aa overlap)%3B NP_063946.1|NM_019893 mitochondrial ceramidase from Homo sapiens (761 aa)%3B P_446098.1|NM_053646 N-acylsphingosine amidohydrolase 2 from Rattus norvegicus (761 aa)%3B BAB09641.1|AB016885 neutral ceramidase from Arabidopsis thaliana (705 aa)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0669c;product=Possible hydrolase;protein_id=CCP43412.1;transl_table=11
AL123456.3	EMBL	gene	769792	770550	.	+	.	ID=gene-Rv0670;Name=end;gbkey=Gene;gene=end;gene_biotype=protein_coding;gene_synonym=nfo;locus_tag=Rv0670
AL123456.3	EMBL	CDS	769792	770550	.	+	0	ID=cds-CCP43413.1;Parent=gene-Rv0670;Dbxref=EnsemblGenomes-Gn:Rv0670,EnsemblGenomes-Tr:CCP43413,GOA:P9WQ13,InterPro:IPR001719,InterPro:IPR013022,InterPro:IPR018246,NCBI_GP:CCP43413.1;Name=CCP43413.1;Note=Rv0670%2C (MTCI376.04c)%2C len: 252 aa. Probable end (alternate gene name: nfo)%2C endonuclease IV (apurinase) (see citation below)%2C equivalent to END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV (apurinase) from Mycobacterium leprae (252 aa)%2C FASTA scores: opt: 1463%2C E(): 0%2C (85.6%25 identity in 250 aa overlap). Also similar to others e.g. Q9S2N2|END4_STRCO|NFO|SC6E10.05 probable endonuclease IV from Streptomyces coelicolor (294 aa)%3B etc. Contains PS00729 AP endonucleases family 2 signatures 1 and 2 (PS00729%2C and PS00730). Belongs to the AP endonucleases family 2. Cofactor: binds 3 zinc ions. The transcription of this CDS seems negatively regulated by the product of mce2R|Rv0586 (See Santangelo et al.%2C 2009).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=end;inference=protein motif:PROSITE:PS00730;locus_tag=Rv0670;product=Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase);protein_id=CCP43413.1;transl_table=11
AL123456.3	EMBL	gene	770582	771424	.	+	.	ID=gene-Rv0671;Name=lpqP;gbkey=Gene;gene=lpqP;gene_biotype=protein_coding;locus_tag=Rv0671
AL123456.3	EMBL	CDS	770582	771424	.	+	0	ID=cds-CCP43414.1;Parent=gene-Rv0671;Dbxref=EnsemblGenomes-Gn:Rv0671,EnsemblGenomes-Tr:CCP43414,InterPro:IPR029058,UniProtKB/TrEMBL:I6XVY0,NCBI_GP:CCP43414.1;Name=CCP43414.1;Note=Rv0671%2C (MTCI376.03c)%2C len: 280 aa. Possible lpqP%2Cconserved lipoprotein%2C similar to U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302 aa)%2C FASTA scores: opt: 449%2CE(): 2.4e-22%2C (37.6%25 identity in 242 aa overlap). Also highly similar to lpqC|Rv3298c|MTCY71.38c putative lipoprotein from Mycobacterium tuberculosis (304 aa). Also similar to a large variety of proteins including various esterases and poly(3-hydroxyalkanoate) depolymerases%2C e.g. NP_249234.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (322 aa)%3B C-terminus of AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase EstA from Piromyces equi (536 aa)%3B part of P52090|PHA1_PSELE poly(3-hydroxyalkanoate) depolymerase C precursor from Pseudomonas lemoignei (414 aa)%3B CAC10310.1|AL442629 putative secreted protein from Streptomyces coelicolor (348 aa)%3B etc. Has a 17 aa signal sequence and contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lpqP;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0671;product=Possible conserved lipoprotein LpqP;protein_id=CCP43414.1;transl_table=11
AL123456.3	EMBL	gene	771484	773112	.	+	.	ID=gene-Rv0672;Name=fadE8;gbkey=Gene;gene=fadE8;gene_biotype=protein_coding;locus_tag=Rv0672
AL123456.3	EMBL	CDS	771484	773112	.	+	0	ID=cds-CCP43415.1;Parent=gene-Rv0672;Dbxref=EnsemblGenomes-Gn:Rv0672,EnsemblGenomes-Tr:CCP43415,GOA:I6X9J0,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,UniProtKB/TrEMBL:I6X9J0,NCBI_GP:CCP43415.1;Name=CCP43415.1;Note=Rv0672%2C (MTCI376.02c)%2C len: 542 aa. Probable fadE8%2Cacyl-CoA dehydrogenase%2C highly similar to many e.g. CAC33951.1|AL589708 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (557 aa)%3B P33224|AIDB_ECOLI|B4187 aidb protein (acyl-CoA dehydrogenases family) from Escherichia coli strain K12 (546 aa)%2C FASTA scores: opt: 1369%2C E(): 0%2C (44.1%25 identity in 524 aa overlap)%3B etc. Also similar to several other M. tuberculosis proteins e.g. Rv0154c|MTCI5.28c FASTA score: (26.3%25 identity in 342 aa overlap)%3B etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073). Belongs to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE8;inference=protein motif:PROSITE:PS00073;locus_tag=Rv0672;product=Probable acyl-CoA dehydrogenase FadE8;protein_id=CCP43415.1;transl_table=11
AL123456.3	EMBL	gene	773123	774061	.	+	.	ID=gene-Rv0673;Name=echA4;gbkey=Gene;gene=echA4;gene_biotype=protein_coding;locus_tag=Rv0673
AL123456.3	EMBL	CDS	773123	774061	.	+	0	ID=cds-CCP43416.1;Parent=gene-Rv0673;Dbxref=EnsemblGenomes-Gn:Rv0673,EnsemblGenomes-Tr:CCP43416,GOA:I6Y8F2,InterPro:IPR001753,InterPro:IPR029045,UniProtKB/TrEMBL:I6Y8F2,NCBI_GP:CCP43416.1;Name=CCP43416.1;Note=Rv0673%2C (MTCI376.01c%2C MTV040.01)%2C len: 312 aa. Possible echA4%2C enoyl-CoA hydratase%2C showing similarity with others e.g. NP_419216.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (256 aa)%3B Q52995|ECHH_RHIME probable enoyl-CoA hydratase from Sinorhizobium meliloti (257 aa)%2C FASTA scores: opt: 210%2C E(): 1.2e-06%2C (27.9%25 identity in 280 aa overlap)%3B etc. Also similar to other enoyl-CoA hydratases from Mycobacterium tuberculosis e.g. P95279|MTCY09F9.29|ECHA13|Rv1935c|MTCY09F9.29 enoyl-CoA hydratase (318 aa)%2C FASTA score: (27.1%25 identity in 280 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA4;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0673;product=Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43416.1;transl_table=11
AL123456.3	EMBL	gene	774064	774786	.	+	.	ID=gene-Rv0674;Name=Rv0674;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0674
AL123456.3	EMBL	CDS	774064	774786	.	+	0	ID=cds-CCP43417.1;Parent=gene-Rv0674;Dbxref=EnsemblGenomes-Gn:Rv0674,EnsemblGenomes-Tr:CCP43417,InterPro:IPR012906,InterPro:IPR013225,UniProtKB/TrEMBL:I6WZ26,NCBI_GP:CCP43417.1;Name=CCP43417.1;Note=Rv0674%2C (MTV040.02)%2C len: 240 aa. Conserved hypothetical protein%2C highly similar to AC13063.1|AL445503 conserved hypothetical protein from Streptomyces coelicolor (268 aa)%3B and similar to NP_438100.1|NC_003078 putative regulator of phenylacetic acid degradation ArsR family protein from Sinorhizobium meliloti (306 aa) and other proteins e.g. AB011837|AB011837_13 hypothetical protein from Bacillus halodurans (298 aa)%2C FASTA scores: opt: 148%2CE(): 0.0081%2C (25.1%25 identity in 235 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0674;product=Conserved hypothetical protein;protein_id=CCP43417.1;transl_table=11
AL123456.3	EMBL	gene	774783	775574	.	+	.	ID=gene-Rv0675;Name=echA5;gbkey=Gene;gene=echA5;gene_biotype=protein_coding;locus_tag=Rv0675
AL123456.3	EMBL	CDS	774783	775574	.	+	0	ID=cds-CCP43418.1;Parent=gene-Rv0675;Dbxref=EnsemblGenomes-Gn:Rv0675,EnsemblGenomes-Tr:CCP43418,GOA:I6Y4E8,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,UniProtKB/TrEMBL:I6Y4E8,NCBI_GP:CCP43418.1;Name=CCP43418.1;Note=Rv0675%2C (MTV040.03)%2C len: 263 aa. Probable echA5%2Cenoyl-CoA hydratase%2C similar to several e.g. NP_252116.1|NC_002516 probable enoyl CoA-hydratase/isomerase from Pseudomonas aeruginosa (256 aa)%3B Q20376 protein similar to enoyl-CoA hydratase from Caenorhabditis elegans (258 aa)%2C FASTA scores: opt: 697%2CE(): 0%2C (47.3%25 identity in 245 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Z92669|MTCY8D5_17 (262 aa)%2C FASTA scores: opt: 493%2C E(): 3.6e-25%2C (39.1%25 identity in 243 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA5;inference=protein motif:PROSITE:PS00166;locus_tag=Rv0675;product=Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43418.1;transl_table=11
AL123456.3	EMBL	gene	775586	778480	.	-	.	ID=gene-Rv0676c;Name=mmpL5;gbkey=Gene;gene=mmpL5;gene_biotype=protein_coding;locus_tag=Rv0676c
AL123456.3	EMBL	CDS	775586	778480	.	-	0	ID=cds-CCP43419.1;Parent=gene-Rv0676c;Dbxref=EnsemblGenomes-Gn:Rv0676c,EnsemblGenomes-Tr:CCP43419,GOA:P9WJV1,InterPro:IPR004707,InterPro:IPR004869,NCBI_GP:CCP43419.1;Name=CCP43419.1;Note=Rv0676c%2C (MTV040.04c)%2C len: 964 aa. Probable mmpL5%2Cconserved transmembrane transport protein (see Tekaia et al.%2C 1999)%2C member of RND superfamily%2C highly similar to other Mycobacterial proteins e.g. MTV037_14%2C MTCY98_8%2CMTCY20G9_34%2C MTCY4D9_15%2C MTCY48_8%2C MTCY19G5_6%2C MTV005_19%2Cetc. Also similar to other Mycobacterial mmpl proteins e.g. P54881|MML4_MYCLE putative membrane protein MMPL4 from Mycobacterium leprae (959 aa)%2C FASTA scores: opt: 3991%2CE(): 0%2C (62.8%25 identity in 933 aa overlap)%3B etc. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL5;locus_tag=Rv0676c;product=Probable conserved transmembrane transport protein MmpL5;protein_id=CCP43419.1;transl_table=11
AL123456.3	EMBL	gene	778477	778905	.	-	.	ID=gene-Rv0677c;Name=mmpS5;gbkey=Gene;gene=mmpS5;gene_biotype=protein_coding;locus_tag=Rv0677c
AL123456.3	EMBL	CDS	778477	778905	.	-	0	ID=cds-CCP43420.1;Parent=gene-Rv0677c;Dbxref=EnsemblGenomes-Gn:Rv0677c,EnsemblGenomes-Tr:CCP43420,GOA:P9WJS7,InterPro:IPR008693,NCBI_GP:CCP43420.1;Name=CCP43420.1;Note=Rv0677c%2C (MTV040.05c)%2C len: 142 aa. Possible mmpS5%2Cconserved membrane protein (see Tekaia et al.%2C 1999)%2Chighly similar to other Mycobacterial proteins e.g. P54880|MMS4_MYCLE putative membrane protein from Mycobacterium leprae (154 aa)%2C FASTA scores: opt: 443%2C E(): 1.4e-23%2C (47.1%25 identity in 155 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis. Belongs to the MmpS family. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpS5;locus_tag=Rv0677c;product=Possible conserved membrane protein MmpS5;protein_id=CCP43420.1;transl_table=11
AL123456.3	EMBL	gene	778990	779487	.	+	.	ID=gene-Rv0678;Name=Rv0678;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0678
AL123456.3	EMBL	CDS	778990	779487	.	+	0	ID=cds-CCP43421.1;Parent=gene-Rv0678;Dbxref=EnsemblGenomes-Gn:Rv0678,EnsemblGenomes-Tr:CCP43421,InterPro:IPR011991,PDB:4NB5,UniProtKB/TrEMBL:I6Y8F7,NCBI_GP:CCP43421.1;Name=CCP43421.1;Note=Rv0678%2C (MTV040.06)%2C len: 165 aa. Conserved protein%2Cshowing weak similarity with AL049754|SCH10_10 hypothetical protein from Streptomyces coelicolor (152 aa)%2C FASTA scores: opt: 149%2C E(): 0.0018%2C (22.9%25 identity in 140 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0678;product=Conserved protein;protein_id=CCP43421.1;transl_table=11
AL123456.3	EMBL	gene	779543	780040	.	-	.	ID=gene-Rv0679c;Name=Rv0679c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0679c
AL123456.3	EMBL	CDS	779543	780040	.	-	0	ID=cds-CCP43422.1;Parent=gene-Rv0679c;Dbxref=EnsemblGenomes-Gn:Rv0679c,EnsemblGenomes-Tr:CCP43422,InterPro:IPR021417,UniProtKB/TrEMBL:I6WZ30,NCBI_GP:CCP43422.1;Name=CCP43422.1;Note=Rv0679c%2C (MTV040.07c)%2C len: 165 aa. Conserved Thr-rich protein%2C similar in part to neighboring ORF Rv0680c (124 aa)%2C FASTA score: (35.1%25 identity in 131 aa overlap)%3B and Rv0314c (220 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0679c;product=Conserved threonine rich protein;protein_id=CCP43422.1;transl_table=11
AL123456.3	EMBL	gene	780042	780416	.	-	.	ID=gene-Rv0680c;Name=Rv0680c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0680c
AL123456.3	EMBL	CDS	780042	780416	.	-	0	ID=cds-CCP43423.1;Parent=gene-Rv0680c;Dbxref=EnsemblGenomes-Gn:Rv0680c,EnsemblGenomes-Tr:CCP43423,GOA:I6Y4F1,InterPro:IPR021417,UniProtKB/TrEMBL:I6Y4F1,NCBI_GP:CCP43423.1;Name=CCP43423.1;Note=Rv0680c%2C (MTV040.08c)%2C len: 124 aa. Possible conserved transmembrane protein%2C showing similarity with C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved hypothetical protein from Mycobacterium tuberculosis (220 aa)%2C FASTA scores: opt: 175%2C E(): 2.2e-05%2C (31.4%25 identity in 102 aa overlap). Also some similarity to upstream ORF Rv0679c|MTV040.07c conserved hypothetical threonine rich protein (124 aa)%2C FASTA score: (35.1%25 identity in 131 aa overlap). Contains possible membrane spanning regions.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0680c;product=Probable conserved transmembrane protein;protein_id=CCP43423.1;transl_table=11
AL123456.3	EMBL	gene	780721	781311	.	+	.	ID=gene-Rv0681;Name=Rv0681;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0681
AL123456.3	EMBL	CDS	780721	781311	.	+	0	ID=cds-CCP43424.1;Parent=gene-Rv0681;Dbxref=EnsemblGenomes-Gn:Rv0681,EnsemblGenomes-Tr:CCP43424,GOA:O53789,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR025996,UniProtKB/TrEMBL:O53789,NCBI_GP:CCP43424.1;Name=CCP43424.1;Note=Rv0681%2C (MTV040.09)%2C len: 196 aa. Probable transcription regulator%2C TetR family%2C similar to others and especially many tetracycline repressors e.g. T34657 probable transcription regulator from Streptomyces coelicolor (189 aa)%3B AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator from Bacillus subtilis (191 aa)%2C FASTA scores: opt: 213%2CE(): 1.6e-07%2C (28.8%25 identity in 153 aa overlap)%3B P09164|TER4_ECOLI tetracycline repressor protein from Escherichia coli (217 aa)%2C FASTA scores: opt: 145%2C E(): 0.0068%2C (39.0%25 identity in 59 aa overlap)%3B etc. Contains helix-turn-helix motif at aa 28-49 (Score 1020%2C +2.66 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0681;product=Probable transcriptional regulatory protein (possibly TetR-family);protein_id=CCP43424.1;transl_table=11
AL123456.3	EMBL	gene	781560	781934	.	+	.	ID=gene-Rv0682;Name=rpsL;gbkey=Gene;gene=rpsL;gene_biotype=protein_coding;locus_tag=Rv0682
AL123456.3	EMBL	CDS	781560	781934	.	+	0	ID=cds-CCP43425.1;Parent=gene-Rv0682;Dbxref=EnsemblGenomes-Gn:Rv0682,EnsemblGenomes-Tr:CCP43425,GOA:P9WH63,InterPro:IPR005679,InterPro:IPR006032,InterPro:IPR012340,NCBI_GP:CCP43425.1;Name=CCP43425.1;Note=Rv0682%2C (MTV040.10)%2C len: 124 aa. rpsL%2C 30S ribosomal protein S12 (see citations below)%2C equivalent to others from Mycobacteria e.g. P41195|RS12_MYCSM 30S ribosomal protein S12 from Mycobacterium smegmatis (124 aa)%3B P51999|RS12_MYCAV 30S ribosomal protein S12 from Mycobacterium avium (124 aa)%3B etc. Also highly similar to others from other organisms e.g. P97222|RS12_STRCO 30S ribosomal protein S12 from Streptomyces roseosporus%2Clividans and coelicolor (123 aa)%3B etc. Contains PS00055 Ribosomal protein S12 signature. Belongs to the S12P family of ribosomal proteins. Nucleotide position 781922 in the genome sequence has been corrected%2C A:G resulting in K121K.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsL;inference=protein motif:PROSITE:PS00055;locus_tag=Rv0682;product=30S ribosomal protein S12 RpsL;protein_id=CCP43425.1;transl_table=11
AL123456.3	EMBL	gene	781934	782404	.	+	.	ID=gene-Rv0683;Name=rpsG;gbkey=Gene;gene=rpsG;gene_biotype=protein_coding;locus_tag=Rv0683
AL123456.3	EMBL	CDS	781934	782404	.	+	0	ID=cds-CCP43426.1;Parent=gene-Rv0683;Dbxref=EnsemblGenomes-Gn:Rv0683,EnsemblGenomes-Tr:CCP43426,GOA:P9WH29,InterPro:IPR000235,InterPro:IPR005717,InterPro:IPR020606,InterPro:IPR023798,NCBI_GP:CCP43426.1;Name=CCP43426.1;Note=Rv0683%2C (MTV040.11)%2C len: 156 aa. rpsG%2C 30S ribosomal protein S7 (see citation below)%2C equivalent to others from Mycobacteria e.g. P41193|RS7_MYCSM 30S ribosomal protein S7 from Mycobacterium smegmatis (156 aa)%2CFASTA scores: opt: 986%2C E(): 0%2C (96.2%25 identity in 156 aa overlap)%3B Q53539|RS7_MYCBO 30S ribosomal protein S7 from Mycobacterium bovis (156 aa)%3B etc. Also highly similar to others e.g. Q9L0K4|RS7_STRCO 30S ribosomal protein S7 from Streptomyces coelicolor (156 aa)%3B etc. Contains PS00052 Ribosomal protein S7 signature. Belongs to the S7P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsG;inference=protein motif:PROSITE:PS00052;locus_tag=Rv0683;product=30S ribosomal protein S7 RpsG;protein_id=CCP43426.1;transl_table=11
AL123456.3	EMBL	gene	782485	784590	.	+	.	ID=gene-Rv0684;Name=fusA1;gbkey=Gene;gene=fusA1;gene_biotype=protein_coding;gene_synonym=fusA;locus_tag=Rv0684
AL123456.3	EMBL	CDS	782485	784590	.	+	0	ID=cds-CCP43427.1;Parent=gene-Rv0684;Dbxref=EnsemblGenomes-Gn:Rv0684,EnsemblGenomes-Tr:CCP43427,GOA:P9WNM7,InterPro:IPR000640,InterPro:IPR000795,InterPro:IPR004161,InterPro:IPR004540,InterPro:IPR005225,InterPro:IPR005517,InterPro:IPR009000,InterPro:IPR009022,InterPro:IPR014721,InterPro:IPR020568,InterPro:IPR027417,NCBI_GP:CCP43427.1;Name=CCP43427.1;Note=Rv0684%2C (MTV040.12%2C MTCY210.01)%2C len: 701 aa. Probable fusA1%2C elongation factor G%2C equivalent to P30767|EFG_MYCLE|S31150 translation elongation factor EF-G from Mycobacterium leprae (701 aa)%2C FASTA scores: opt: 2521%2C E(): 0%2C (88.2%25 identity in 432 aa overlap). Also highly similar to others e.g. CAB81852.1|AL161691 elongation factor G from Streptomyces coelicolor (708 aa)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature. Belongs to the GTP-binding elongation factor family%2CEF-G/EF-2 subfamily. Note that previously known as fusA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fusA1;inference=protein motif:PROSITE:PS00301;locus_tag=Rv0684;product=Probable elongation factor G FusA1 (EF-G);protein_id=CCP43427.1;transl_table=11
AL123456.3	EMBL	gene	784821	786011	.	+	.	ID=gene-Rv0685;Name=tuf;gbkey=Gene;gene=tuf;gene_biotype=protein_coding;locus_tag=Rv0685
AL123456.3	EMBL	CDS	784821	786011	.	+	0	ID=cds-CCP43428.1;Parent=gene-Rv0685;Dbxref=EnsemblGenomes-Gn:Rv0685,EnsemblGenomes-Tr:CCP43428,GOA:P9WNN1,InterPro:IPR000795,InterPro:IPR004160,InterPro:IPR004161,InterPro:IPR004541,InterPro:IPR005225,InterPro:IPR009000,InterPro:IPR009001,InterPro:IPR027417,NCBI_GP:CCP43428.1;Name=CCP43428.1;Note=Rv0685%2C (MTCY210.02)%2C len: 396 aa. Probable tuf%2Ciron-regulated elongation factor EF-Tu%2C equivalent to JC2262 translation elongation factor Tu from Mycobacterium leprae (396 aa). Also highly similar to others e.g. P42439|EFTU_CORGL elongation factor TU (EF-TU) from Corynebacterium glutamicum (396 aa)%3B etc. Contains PS00017 ATP/GTP-binding site motif A%2C and PS00301 GTP-binding elongation factors signature. Belongs to the GTP-binding elongation factor family%2C EF-TU/EF-1A subfamily. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tuf;inference=protein motif:PROSITE:PS00301;locus_tag=Rv0685;product=Probable iron-regulated elongation factor TU Tuf (EF-TU);protein_id=CCP43428.1;transl_table=11
AL123456.3	EMBL	gene	786149	786946	.	+	.	ID=gene-Rv0686;Name=Rv0686;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0686
AL123456.3	EMBL	CDS	786149	786946	.	+	0	ID=cds-CCP43429.1;Parent=gene-Rv0686;Dbxref=EnsemblGenomes-Gn:Rv0686,EnsemblGenomes-Tr:CCP43429,UniProtKB/TrEMBL:I6XVZ6,NCBI_GP:CCP43429.1;Name=CCP43429.1;Note=Rv0686%2C (MTCY210.03)%2C len: 265 aa. Probable membrane protein%2C with hydrophobic N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0686;product=Probable membrane protein;protein_id=CCP43429.1;transl_table=11
AL123456.3	EMBL	gene	787099	787926	.	+	.	ID=gene-Rv0687;Name=Rv0687;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0687
AL123456.3	EMBL	CDS	787099	787926	.	+	0	ID=cds-CCP43430.1;Parent=gene-Rv0687;Dbxref=EnsemblGenomes-Gn:Rv0687,EnsemblGenomes-Tr:CCP43430,GOA:P9WGS7,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,InterPro:IPR023985,NCBI_GP:CCP43430.1;Name=CCP43430.1;Note=Rv0687%2C (MTCY210.04)%2C len: 275 aa. Probable short-chain dehydrogenase/reductase%2C highly similar to various dehydrogenases (generally SDR family) e.g. U17129|RSU17129_7 short-chain dehydrogenase from Rhodococcus erythropolis (275 aa)%2C FASTA scores: opt: 1112%2CE(): 0%2C (61.2%25 identity in 268 aa overlap)%3B MMU34072_2 steroid dehydrogenase from Musmus culus (260 aa)%2C FASTA scores: opt: 390%2C E(): 2.2e-17%2C (34.1%25 identity in 267 aa overlap)%3B etc. Also similar to MTV002_16|O33292|Rv2750 dehydrogenase from Mycobacterium tuberculosis (272 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0687;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP43430.1;transl_table=11
AL123456.3	EMBL	gene	787940	789160	.	+	.	ID=gene-Rv0688;Name=Rv0688;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0688
AL123456.3	EMBL	CDS	787940	789160	.	+	0	ID=cds-CCP43431.1;Parent=gene-Rv0688;Dbxref=EnsemblGenomes-Gn:Rv0688,EnsemblGenomes-Tr:CCP43431,GOA:P95034,InterPro:IPR001327,InterPro:IPR004099,InterPro:IPR013027,InterPro:IPR016156,InterPro:IPR023753,InterPro:IPR028202,UniProtKB/TrEMBL:P95034,NCBI_GP:CCP43431.1;Name=CCP43431.1;Note=Rv0688%2C (MTCY210.05)%2C len: 406 aa. Putative ferredoxin reductase%2C highly similar to others e.g. BAB55881.1|AB054975 ferredoxin reductase from Terrabacter sp. DBF63 (410 aa)%3B CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa)%3B PPU24215_8|Q51973 P-cumate dioxygenase ferredoxin reductase subunit from Pseudomonas putida (402 aa)%2C FASTA scores: opt: 738%2C E(): 0%2C (38.8%25 identity in 330 aa overlap)%3B etc. Also similar to Rv0253 and Rv1869c from Mycobacterium tuberculosis. Could belong to the bacterial type ferredoxin family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0688;product=Putative ferredoxin reductase;protein_id=CCP43431.1;transl_table=11
AL123456.3	EMBL	gene	789157	789411	.	-	.	ID=gene-Rv0689c;Name=Rv0689c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0689c
AL123456.3	EMBL	CDS	789157	789411	.	-	0	ID=cds-CCP43432.1;Parent=gene-Rv0689c;Dbxref=EnsemblGenomes-Gn:Rv0689c,EnsemblGenomes-Tr:CCP43432,UniProtKB/TrEMBL:I6WZ39,NCBI_GP:CCP43432.1;Name=CCP43432.1;Note=Rv0689c%2C (MTCY210.06c)%2C len: 84 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0689c;product=Hypothetical protein;protein_id=CCP43432.1;transl_table=11
AL123456.3	EMBL	gene	790024	791073	.	-	.	ID=gene-Rv0690c;Name=Rv0690c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0690c
AL123456.3	EMBL	CDS	790024	791073	.	-	0	ID=cds-CCP43433.1;Parent=gene-Rv0690c;Dbxref=EnsemblGenomes-Gn:Rv0690c,EnsemblGenomes-Tr:CCP43433,InterPro:IPR011200,UniProtKB/TrEMBL:I6Y4G1,NCBI_GP:CCP43433.1;Name=CCP43433.1;Note=Rv0690c%2C (MTCY210.07c)%2C len: 349 aa. Conserved hypothetical protein%2C showing similarity with NP_386956.1|NC_003047 conserved hypothetical protein from Sinorhizobium meliloti (358 aa)%3B NP_356573.1|NC_003063 AGR_L_1570p from Agrobacterium tumefaciens (346 aa)%3B NP_421938.1|NC_002696 conserved hypothetical protein from Caulobacter crescentus (370 aa).;gbkey=CDS;locus_tag=Rv0690c;product=Conserved hypothetical protein;protein_id=CCP43433.1;transl_table=11
AL123456.3	EMBL	gene	791070	791666	.	-	.	ID=gene-Rv0691c;Name=Rv0691c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0691c
AL123456.3	EMBL	CDS	791070	791666	.	-	0	ID=cds-CCP43434.1;Parent=gene-Rv0691c;Dbxref=EnsemblGenomes-Gn:Rv0691c,EnsemblGenomes-Tr:CCP43434,GOA:P9WMB7,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,InterPro:IPR023851,NCBI_GP:CCP43434.1;Name=CCP43434.1;Note=Rv0691c%2C (MTCY210.08c)%2C len: 198 aa. Probable transcriptional regulator%2C highly similar to AAC77476.1|U17129 unknown protein from Rhodococcus erythropolis (185 aa)%3B and showing similarity with putative regulatory proteins eg STMTCREP_1|TCMR_STRGA|P39885 tetracenomycin c transcriptional repressor from Streptomyces glaucescens (226 aa)%2C FASTA scores: opt: 178%2CE(): 8.5e-06%2C (27.9%25 identity in 201 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and probable helix-turn helix motifs from aa 34-55 (Score 1100%2C+2.93 SD) and 151-172 (Score 1124%2C +3.02 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0691c;product=Probable transcriptional regulatory protein;protein_id=CCP43434.1;transl_table=11
AL123456.3	EMBL	gene	791658	791846	.	+	.	ID=gene-Rv0691A;Name=Rv0691A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0691A
AL123456.3	EMBL	CDS	791658	791846	.	+	0	ID=cds-CCP43435.1;Parent=gene-Rv0691A;Dbxref=EnsemblGenomes-Gn:Rv0691A,EnsemblGenomes-Tr:CCP43435,InterPro:IPR023988,NCBI_GP:CCP43435.1;Name=CCP43435.1;Note=Rv0691A%2C len: 62 aa. Mycofactocin precursor protein.;gbkey=CDS;locus_tag=Rv0691A;product=Mycofactocin precursor protein;protein_id=CCP43435.1;transl_table=11
AL123456.3	EMBL	gene	791831	792160	.	+	.	ID=gene-Rv0692;Name=Rv0692;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0692
AL123456.3	EMBL	CDS	791831	792160	.	+	0	ID=cds-CCP43436.1;Parent=gene-Rv0692;Dbxref=EnsemblGenomes-Gn:Rv0692,EnsemblGenomes-Tr:CCP43436,InterPro:IPR023850,NCBI_GP:CCP43436.1;Name=CCP43436.1;Note=Rv0692%2C (MTCY210.09)%2C len: 109 aa. Conserved hypothetical protein%2C highly similar to U17129|RSU17129_3|AAC77477.1 unknown protein from Rhodococcus erythropolis (95 aa)%2C FASTA scores: opt: 393%2CE(): 8.8e-22%2C (68.2%25 identity in 88 aa overlap).;gbkey=CDS;locus_tag=Rv0692;product=Conserved hypothetical protein;protein_id=CCP43436.1;transl_table=11
AL123456.3	EMBL	gene	792157	793332	.	+	.	ID=gene-Rv0693;Name=pqqE;gbkey=Gene;gene=pqqE;gene_biotype=protein_coding;gene_synonym=pqqIII;locus_tag=Rv0693
AL123456.3	EMBL	CDS	792157	793332	.	+	0	ID=cds-CCP43437.1;Parent=gene-Rv0693;Dbxref=EnsemblGenomes-Gn:Rv0693,EnsemblGenomes-Tr:CCP43437,GOA:P9WJ79,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR013785,InterPro:IPR017200,InterPro:IPR023885,InterPro:IPR023913,NCBI_GP:CCP43437.1;Name=CCP43437.1;Note=Rv0693%2C (MTCY210.10)%2C len: 391 aa. Probable pqqE (alternate gene name: pqqIII)%2C coenzyme PQQ synthesis protein E%2C similar to others AE001109_9|O30258|PQQE coenzyme PQQ synthesis protein from Archaeoglobus fulgidus (375 aa)%2C FASTA scores: E(): 1.6e-16%2C (28.1%25 identity in 377 aa overlap)%3B PQQE_ACICA|P07782 coenzyme pqq synthesis protein e from Acinetobacter calcoaceticus (384 aa)%2C FASTA scores: opt: 302%2C E(): 1.8e-12%2C (23.9%25 identity in 377 aa overlap)%3B etc. Also similar to C-terminus of heme biosynthesis proteins e.g. O28270|AF2009 heme biosynthesis protein (NIRJ-2) from Archaeoglobus fulgidus (468 aa). Note that also highly similar to U17129|RSU17129_4|AAC77478.1 unknown protein from Rhodococcus erythropolis (405 aa)%2CFASTA scores: opt: 1997%2C E(): 0%2C (73.3%25 identity in 390 aa overlap). Could belong to the MoaA / NifB / PqqE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pqqE;locus_tag=Rv0693;product=Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III);protein_id=CCP43437.1;transl_table=11
AL123456.3	EMBL	gene	793335	794525	.	+	.	ID=gene-Rv0694;Name=lldD1;gbkey=Gene;gene=lldD1;gene_biotype=protein_coding;locus_tag=Rv0694
AL123456.3	EMBL	CDS	793335	794525	.	+	0	ID=cds-CCP43438.1;Parent=gene-Rv0694;Dbxref=EnsemblGenomes-Gn:Rv0694,EnsemblGenomes-Tr:CCP43438,GOA:P9WND7,InterPro:IPR000262,InterPro:IPR012133,InterPro:IPR013785,InterPro:IPR023989,NCBI_GP:CCP43438.1;Name=CCP43438.1;Note=Rv0694%2C (MTCY210.11)%2C len: 396 aa. Possible lldD1%2CL-lactate dehydrogenase (cytochrome)%2C similar to NP_302368.1|NC_002677 L-lactate dehydrogenase from Mycobacterium leprae (414 aa). Also similar to others e.g. NP_384560.1|NC_003047 putative L-lactate dehydrogenase (cytochrome) protein from Sinorhizobium meliloti (403 aa)%3B NP_251072.1|NC_002516 L-lactate dehydrogenase from Pseudomonas aeruginosa (383 aa)%3B P33232|LLDD_ECOLI L-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa)%2C FASTA scores: opt: 697%2C E(): 0%2C (34.5 identity in 380 aa overlap)%3B etc%3B and also similar to other oxidoreductases. Note that also highly similar to RSU17129_5|AAC77479.1|U17129 unknown protein from Rhodococcus erythropolis (392 aa)%2C FASTA scores: opt: 2006%2CE(): 0%2C (74.1%25 identity in 386 aa overlap). Also similar to lldD2|Rv1872c|MTCY180.46|MTCY359.01 possible L-lactate dehydrogenase (cytochrome) from Mycobacterium tuberculosis (414 aa). Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lldD1;locus_tag=Rv0694;product=Possible L-lactate dehydrogenase (cytochrome) LldD1;protein_id=CCP43438.1;transl_table=11
AL123456.3	EMBL	gene	794715	795470	.	+	.	ID=gene-Rv0695;Name=Rv0695;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0695
AL123456.3	EMBL	CDS	794715	795470	.	+	0	ID=cds-CCP43439.1;Parent=gene-Rv0695;Dbxref=EnsemblGenomes-Gn:Rv0695,EnsemblGenomes-Tr:CCP43439,GOA:P9WP59,InterPro:IPR003785,InterPro:IPR023871,InterPro:IPR024087,NCBI_GP:CCP43439.1;Name=CCP43439.1;Note=Rv0695%2C (MTCY210.12)%2C len: 251 aa. Conserved hypothetical protein%2C similar to many creatinine amidohydrolases or hypothetical proteins e.g. NP_443048.1|NC_000911 creatinine amidohydrolase from Synechococcus sp. PCC 6803 (273 aa)%3B NP_466169.1|NC_003210 protein similar to creatinine amidohydrolase from Listeria monocytogenes (249 aa)%3B T35153|SC5A7.04c hypothetical protein from Streptomyces coelicolor (273 aa)%3B etc. Note that highly similar to RSU17129_10|AAC77474.1|U17129 unknown protein from Rhodococcus erythropolis (230 aa)%2CFASTA scores: opt: 693%2C E(): 0%2C (55.7%25 identity in 237 aa overlap).;gbkey=CDS;locus_tag=Rv0695;product=Conserved hypothetical protein;protein_id=CCP43439.1;transl_table=11
AL123456.3	EMBL	repeat_region	795467	795518	.	+	.	ID=id-AL123456.3:795467..795518;Note=52 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	795519	796931	.	+	.	ID=gene-Rv0696;Name=Rv0696;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0696
AL123456.3	EMBL	CDS	795519	796931	.	+	0	ID=cds-CCP43440.1;Parent=gene-Rv0696;Dbxref=EnsemblGenomes-Gn:Rv0696,EnsemblGenomes-Tr:CCP43440,GOA:P9WMX1,InterPro:IPR001173,InterPro:IPR023981,InterPro:IPR029044,NCBI_GP:CCP43440.1;Name=CCP43440.1;Note=Rv0696%2C (MTCY210.13)%2C len: 470 aa. Probable membrane sugar transferase%2C similar (except in N-terminus) to NP_069157.1|NC_000917 glycosyl transferase from Archaeoglobus fulgidus (324 aa)%3B NP_279985.1|NC_002607 rhamnosyl transferase from Halobacterium sp. NRC-1 (299 aa)%3B NP_059113.1|NM_017417 polypeptide N-acetylgalactosaminyltransferase 8 from (637 aa). Note that also highly similar to P46370|YTH1_RHOER hypothetical 55.3 KDA protein from Rhodococcus erythropolis (513 aa)%2CFASTA scores: opt: 1514%2C E(): 0%2C (51.8%25 identity in 469 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0696;product=Probable membrane sugar transferase;protein_id=CCP43440.1;transl_table=11
AL123456.3	EMBL	gene	796933	798372	.	+	.	ID=gene-Rv0697;Name=Rv0697;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0697
AL123456.3	EMBL	CDS	796933	798372	.	+	0	ID=cds-CCP43441.1;Parent=gene-Rv0697;Dbxref=EnsemblGenomes-Gn:Rv0697,EnsemblGenomes-Tr:CCP43441,GOA:I6Y8H4,InterPro:IPR000172,InterPro:IPR007867,InterPro:IPR012132,InterPro:IPR023978,UniProtKB/TrEMBL:I6Y8H4,NCBI_GP:CCP43441.1;Name=CCP43441.1;Note=Rv0697%2C (MTCY210.14%2C unknown)%2C len: 479 aa. Probable dehydrogenase%2C highly similar to P30772|YTUR_MYCLE hypothetical 24 kDa protein from Mycobacterium leprae (220 aa)%2C FASTA scores: opt: 557%2C E(): 1.7e-28%2C (46.2%25 identity in 223 aa overlap). Also highly similar to P46371|YTH2_RHOER hypothetical 53.0 KDA GMC-type oxidoreductase from Rhodococcus erythropolis (493 aa)%3B and similar to many dehydrogenases e.g. NP_250814.1|NC_002516 probable dehydrogenase from Pseudomonas aeruginosa (545 aa)%3B BAA13145.1|D86622 FAD dependent L-sorbose dehydrogenase from Gluconobacter oxydans (531 aa)%3B etc. Also similar to Rv1279 conserved hypothetical protein from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0697;product=Probable dehydrogenase;protein_id=CCP43441.1;transl_table=11
AL123456.3	EMBL	gene	798833	799444	.	+	.	ID=gene-Rv0698;Name=Rv0698;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0698
AL123456.3	EMBL	CDS	798833	799444	.	+	0	ID=cds-CCP43442.1;Parent=gene-Rv0698;Dbxref=EnsemblGenomes-Gn:Rv0698,EnsemblGenomes-Tr:CCP43442,UniProtKB/TrEMBL:P95044,NCBI_GP:CCP43442.1;Name=CCP43442.1;Note=Rv0698%2C (MTCY210.15)%2C len: 203 aa. Conserved hypothetical protein%2C highly similar to C-terminus of Rv3639c|MTY15C10.12 conserved hypothetical protein from Mycobacterium tuberculosis (188 aa)%2C FASTA scores: E(): 2.1e-07%2C (54.8%25 identity in 73 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0698;product=Conserved hypothetical protein;protein_id=CCP43442.1;transl_table=11
AL123456.3	EMBL	gene	799629	799850	.	+	.	ID=gene-Rv0699;Name=Rv0699;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0699
AL123456.3	EMBL	CDS	799629	799850	.	+	0	ID=cds-CCP43443.1;Parent=gene-Rv0699;Dbxref=EnsemblGenomes-Gn:Rv0699,EnsemblGenomes-Tr:CCP43443,GOA:P95046,UniProtKB/TrEMBL:P95046,NCBI_GP:CCP43443.1;Name=CCP43443.1;Note=Rv0699%2C (MTCY210.17)%2C len: 73 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0699;product=Hypothetical protein;protein_id=CCP43443.1;transl_table=11
AL123456.3	EMBL	gene	800487	800792	.	+	.	ID=gene-Rv0700;Name=rpsJ;gbkey=Gene;gene=rpsJ;gene_biotype=protein_coding;gene_synonym=nusE;locus_tag=Rv0700
AL123456.3	EMBL	CDS	800487	800792	.	+	0	ID=cds-CCP43444.1;Parent=gene-Rv0700;Dbxref=EnsemblGenomes-Gn:Rv0700,EnsemblGenomes-Tr:CCP43444,GOA:P9WH67,InterPro:IPR001848,InterPro:IPR018268,InterPro:IPR027486,NCBI_GP:CCP43444.1;Name=CCP43444.1;Note=Rv0700%2C (MTCY210.19)%2C len: 101 aa. rpsJ (alternate gene name: nusE)%2C 30S ribosomal protein S10 (see Gopal et al.%2C 2001)%2C equivalent to RS10_MYCLE P307653 30S ribosomal protein S10 from Mycobacterium leprae (101 aa)%2C FASTA scores: opt: 645%2C E(): 0%2C (97.0%25 identity in 101 aa overlap). Also highly similar to others e.g. CAB82069.1|AL161803 30S ribosomal protein S10 from Streptomyces coelicolor (102 aa)%3B etc. Contains PS00361 Ribosomal protein S10 signature. Belongs to the S10P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsJ;inference=protein motif:PROSITE:PS00361;locus_tag=Rv0700;product=30S ribosomal protein S10 RpsJ (transcription antitermination factor NusE);protein_id=CCP43444.1;transl_table=11
AL123456.3	EMBL	gene	800809	801462	.	+	.	ID=gene-Rv0701;Name=rplC;gbkey=Gene;gene=rplC;gene_biotype=protein_coding;locus_tag=Rv0701
AL123456.3	EMBL	CDS	800809	801462	.	+	0	ID=cds-CCP43445.1;Parent=gene-Rv0701;Dbxref=EnsemblGenomes-Gn:Rv0701,EnsemblGenomes-Tr:CCP43445,GOA:P9WH87,InterPro:IPR000597,InterPro:IPR009000,InterPro:IPR019926,InterPro:IPR019927,NCBI_GP:CCP43445.1;Name=CCP43445.1;Note=Rv0701%2C (MTCY210.20)%2C len: 217 aa. rplC%2C 50S ribosomal protein L3%2C equivalent to O06044|RL3_MYCBO 50S ribosomal protein L3 from Mycobacterium bovis BCG (217 aa)%3B and P30762|RL3_MYCLE 50S ribosomal protein L3 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. CAB82070.1|AL161803 50S ribosomal protein L3 from Streptomyces coelicolor (214 aa)%3B P52860|RL3_THETH ribosomal protein l3 from Thermus aquaticus (206 aa)%2C FASTA scores: opt: 717%2C E(): 0%2C (55.2%25 identity in 210 aa overlap)%3B etc. Contains PS00474 Ribosomal protein L3 signature. Belongs to the L3P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplC;inference=protein motif:PROSITE:PS00474;locus_tag=Rv0701;product=50S ribosomal protein L3 RplC;protein_id=CCP43445.1;transl_table=11
AL123456.3	EMBL	gene	801462	802133	.	+	.	ID=gene-Rv0702;Name=rplD;gbkey=Gene;gene=rplD;gene_biotype=protein_coding;locus_tag=Rv0702
AL123456.3	EMBL	CDS	801462	802133	.	+	0	ID=cds-CCP43446.1;Parent=gene-Rv0702;Dbxref=EnsemblGenomes-Gn:Rv0702,EnsemblGenomes-Tr:CCP43446,GOA:P9WH85,InterPro:IPR002136,InterPro:IPR013005,InterPro:IPR023574,NCBI_GP:CCP43446.1;Name=CCP43446.1;Note=Rv0702%2C (MTCY210.21)%2C len: 223 aa. rplD%2C 50S ribosomal protein L4%2C equivalent to O06045|RL4_MYCBO 50S ribosomal protein L4 from Mycobacterium bovis BCG (223 aa)%3B O06114|RL4_MYCSM 50S ribosomal protein L4 from Mycobacterium smegmatis (215 aa)%3B and MLCB2492_3 50S ribosomal protein L4 from Mycobacterium leprae (230 aa). Also highly similar to others e.g. CAB82071.1|AL161803 50S ribosomal protein L4 from Streptomyces coelicolor (219 aa)%3B P28601|RL4_BACST 50s ribosomal protein L4 from Bacillus stearothermophilus (207 aa)%2C FASTA scores: opt: 522%2C E(): 3.5e-26%2C (42.4%25 identity in 198 aa overlap)%3B etc. Belongs to the L4P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplD;locus_tag=Rv0702;product=50S ribosomal protein L4 RplD;protein_id=CCP43446.1;transl_table=11
AL123456.3	EMBL	gene	802133	802435	.	+	.	ID=gene-Rv0703;Name=rplW;gbkey=Gene;gene=rplW;gene_biotype=protein_coding;locus_tag=Rv0703
AL123456.3	EMBL	CDS	802133	802435	.	+	0	ID=cds-CCP43447.1;Parent=gene-Rv0703;Dbxref=EnsemblGenomes-Gn:Rv0703,EnsemblGenomes-Tr:CCP43447,GOA:P9WHB9,InterPro:IPR001014,InterPro:IPR012677,InterPro:IPR012678,InterPro:IPR013025,NCBI_GP:CCP43447.1;Name=CCP43447.1;Note=Rv0703%2C (MTCY21.22)%2C len: 100 aa. rplW%2C 50S ribosomal protein L23%2C equivalent to O06046|RL23_MYCBO 50S ribosomal protein L23 from Mycobacterium bovis BCG (100 aa)%3B and MLCB2492_4 50S ribosomal protein L23 from Mycobacterium leprae (100 aa). Also highly similar to others e.g. CAB82072.1|AL161803 50S ribosomal protein L23 from Streptomyces coelicolor (139 aa) (N-terminus longer)%3B P04454|RL23_BACST 50s ribosomal protein L23 from Bacillus stearothermophilus (95 aa)%2C FASTA scores: opt: 275%2C E(): 1.4e-13%2C (50.5%25 identity in 95 aa overlap)%3B etc. Contains PS00050 Ribosomal protein L23 signature. Belongs to the L23P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplW;inference=protein motif:PROSITE:PS00050;locus_tag=Rv0703;product=50S ribosomal protein L23 RplW;protein_id=CCP43447.1;transl_table=11
AL123456.3	EMBL	repeat_region	802429	802477	.	+	.	ID=id-AL123456.3:802429..802477;Note=49 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	802528	803370	.	+	.	ID=gene-Rv0704;Name=rplB;gbkey=Gene;gene=rplB;gene_biotype=protein_coding;locus_tag=Rv0704
AL123456.3	EMBL	CDS	802528	803370	.	+	0	ID=cds-CCP43448.1;Parent=gene-Rv0704;Dbxref=EnsemblGenomes-Gn:Rv0704,EnsemblGenomes-Tr:CCP43448,GOA:P9WHA5,InterPro:IPR002171,InterPro:IPR005880,InterPro:IPR008991,InterPro:IPR012340,InterPro:IPR014722,InterPro:IPR014726,InterPro:IPR022666,InterPro:IPR022669,InterPro:IPR022671,NCBI_GP:CCP43448.1;Name=CCP43448.1;Note=Rv0704%2C (MTCY210.23)%2C len: 280 aa. rplB%2C 50S ribosomal protein L2%2C equivalent to O06047|RL2_MYCBO 50S ribosomal protein L2 from Mycobacterium bovis BCG (280 aa)%3B and MLCB2492_5M 50S ribosomal protein L2 from Mycobacterium leprae (280 aa). Also highly similar to others e.g. CAB82073.1|AL161803 50S ribosomal protein L2 from Streptomyces coelicolor (278 aa)%3B P42919|RL2_BACSU 50s ribosomal protein l2 (bl2) from Bacillus subtilis (276 aa)%2CFASTA scores: opt: 1179%2C E(): 0%2C (61.1%25 identity in 275 aa overlap)%3B etc. Contains PS00467 Ribosomal protein L2 signature. Belongs to the L2P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplB;inference=protein motif:PROSITE:PS00467;locus_tag=Rv0704;product=50S ribosomal protein L2 RplB;protein_id=CCP43448.1;transl_table=11
AL123456.3	EMBL	gene	803411	803692	.	+	.	ID=gene-Rv0705;Name=rpsS;gbkey=Gene;gene=rpsS;gene_biotype=protein_coding;locus_tag=Rv0705
AL123456.3	EMBL	CDS	803411	803692	.	+	0	ID=cds-CCP43449.1;Parent=gene-Rv0705;Dbxref=EnsemblGenomes-Gn:Rv0705,EnsemblGenomes-Tr:CCP43449,GOA:P9WH45,InterPro:IPR002222,InterPro:IPR005732,InterPro:IPR020934,InterPro:IPR023575,NCBI_GP:CCP43449.1;Name=CCP43449.1;Note=Rv0705%2C (MTCY210.24)%2C len: 93 aa. rpsS%2C 30S ribosomal protein S19%2C equivalent to S36895 ribosomal protein S19 from Mycobacterium bovis (93 aa)%2C FASTA scores: opt: 623%2C E(): 0%2C (98.9%25 identity in 93 aa overlap)%3B and NP_302261.1|NC_002677 30S ribosomal protein S19 from Mycobacterium leprae (93 aa). Also highly similar to others e.g. CAB82074.1|AL161803 30S ribosomal protein S19 from Streptomyces coelicolor (93 aa)%3B etc. Contains PS00323 Ribosomal protein S19 signature. Belongs to the S19P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsS;inference=protein motif:PROSITE:PS00323;locus_tag=Rv0705;product=30S ribosomal protein S19 RpsS;protein_id=CCP43449.1;transl_table=11
AL123456.3	EMBL	gene	803689	804282	.	+	.	ID=gene-Rv0706;Name=rplV;gbkey=Gene;gene=rplV;gene_biotype=protein_coding;locus_tag=Rv0706
AL123456.3	EMBL	CDS	803689	804282	.	+	0	ID=cds-CCP43450.1;Parent=gene-Rv0706;Dbxref=EnsemblGenomes-Gn:Rv0706,EnsemblGenomes-Tr:CCP43450,GOA:P9WHC1,InterPro:IPR001063,InterPro:IPR005727,InterPro:IPR018260,NCBI_GP:CCP43450.1;Name=CCP43450.1;Note=Rv0706%2C (MTCY210.25)%2C len: 197 aa. rplV%2C 50S ribosomal protein L22%2C equivalent to O06115|RL22_MYCSM 50S ribosomal protein L22 from Mycobacterium smegmatis (153 aa)%3B MBS10OPER_7 50S ribosomal protein L22 from Mycobacterium bovis BCG%3B and MLCB2492_7 50S ribosomal protein L22 from Mycobacterium leprae (175 aa). Also highly similar to others e.g. CAB82075.1|AL161803 50S ribosomal protein L22 from Streptomyces coelicolor (125 aa)%3B P42060|RL22_BACSU 50s ribosomal protein L22 from Bacillus subtilis (113 aa)%2C FASTA scores: opt: 368%2C E(): 2.4e-13%2C(52.8%25 identity in 108 aa overlap)%3B etc. Contains PS00464 Ribosomal protein L22 signature%2C and contains repetitive sequence at C-terminus. Belongs to the L22P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplV;inference=protein motif:PROSITE:PS00464;locus_tag=Rv0706;product=50S ribosomal protein L22 RplV;protein_id=CCP43450.1;transl_table=11
AL123456.3	EMBL	gene	804282	805106	.	+	.	ID=gene-Rv0707;Name=rpsC;gbkey=Gene;gene=rpsC;gene_biotype=protein_coding;locus_tag=Rv0707
AL123456.3	EMBL	CDS	804282	805106	.	+	0	ID=cds-CCP43451.1;Parent=gene-Rv0707;Dbxref=EnsemblGenomes-Gn:Rv0707,EnsemblGenomes-Tr:CCP43451,GOA:P9WH37,InterPro:IPR001351,InterPro:IPR004044,InterPro:IPR004087,InterPro:IPR005704,InterPro:IPR009019,InterPro:IPR015946,InterPro:IPR018280,NCBI_GP:CCP43451.1;Name=CCP43451.1;Note=Rv0707%2C (MTCY210.26)%2C len: 274 aa. rpsC%2C 30S ribosomal protein S3%2C equivalent to O06048|RS3_MYCBO|MBS10OPER_8 30S ribosomal protein S3 from Mycobacterium bovis BCG (274 aa)%3B and MLCB2492_8 30S ribosomal protein S3 from Mycobacterium leprae (281 aa). Also highly similar to others e.g. CAB82076.1|AL161803 30S ribosomal protein S3 from Streptomyces coelicolor (277 aa)%3B P21465|RS3_BACSU 30s ribosomal protein s3 (bs3) (bs2) from Bacillus subtilis (217 aa)%2C FASTA scores: opt: 794%2C E(): 0%2C(52.8%25 identity in 212 aa overlap)%3B etc. Belongs to the S3P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsC;locus_tag=Rv0707;product=30S ribosomal protein S3 RpsC;protein_id=CCP43451.1;transl_table=11
AL123456.3	EMBL	gene	805110	805526	.	+	.	ID=gene-Rv0708;Name=rplP;gbkey=Gene;gene=rplP;gene_biotype=protein_coding;locus_tag=Rv0708
AL123456.3	EMBL	CDS	805110	805526	.	+	0	ID=cds-CCP43452.1;Parent=gene-Rv0708;Dbxref=EnsemblGenomes-Gn:Rv0708,EnsemblGenomes-Tr:CCP43452,GOA:P9WHD5,InterPro:IPR000114,InterPro:IPR016180,InterPro:IPR020798,NCBI_GP:CCP43452.1;Name=CCP43452.1;Note=Rv0708%2C (MTCY210.27)%2C len: 138 aa. rplP%2C 50S ribosomal protein L16%2C equivalent to O06049|RL16_MYCBO|MBS10OPER_9 50S ribosomal protein L16 from Mycobacterium bovis BCG (138 aa)%3B and MLCB2492_9 50S ribosomal protein L16 from Mycobacterium leprae (138 aa). Also highly similar to others e.g. CAB82077.1|AL161803 50S ribosomal protein L16 from Streptomyces coelicolor (139 aa)%3B P14577|RL16_BACSU 50s ribosomal protein l16 from Bacillus subtilis (144 aa)%2C FASTA scores: opt: 600%2C E(): 0%2C(63.2%25 identity in 136 aa overlap)%3B etc. Contains PS00701 Ribosomal protein L16 signature 2. Belongs to the L16P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplP;inference=protein motif:PROSITE:PS00701;locus_tag=Rv0708;product=50S ribosomal protein L16 RplP;protein_id=CCP43452.1;transl_table=11
AL123456.3	EMBL	gene	805526	805759	.	+	.	ID=gene-Rv0709;Name=rpmC;gbkey=Gene;gene=rpmC;gene_biotype=protein_coding;locus_tag=Rv0709
AL123456.3	EMBL	CDS	805526	805759	.	+	0	ID=cds-CCP43453.1;Parent=gene-Rv0709;Dbxref=EnsemblGenomes-Gn:Rv0709,EnsemblGenomes-Tr:CCP43453,GOA:P9WHA7,InterPro:IPR001854,InterPro:IPR018254,NCBI_GP:CCP43453.1;Name=CCP43453.1;Note=Rv0709%2C (MTCY210.28)%2C len: 77 aa. rpmC%2C 50S ribosomal protein L29%2C equivalent to O06050|RL29_MYCBO|MBS10OPER_10 50S ribosomal protein L29 from Mycobacterium bovis BCG (75 aa)%3B and O32989|RL29_MYCLE|MLCB2492_10 50S ribosomal protein L29 from Mycobacterium leprae (80 aa). Also highly similar to others e.g. Q9L0D2|RL29_STRCO 50S ribosomal protein L29 from Streptomyces coelicolor (74 aa)%3B P12873|RL29_BACSU 50s ribosomal protein l29 from Bacillus subtilis (66 aa)%2C FASTA scores: opt: 225%2C E(): 8.3e-11%2C (58.6%25 identity in 58 aa overlap)%3B etc. Belongs to the L29P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpmC;locus_tag=Rv0709;product=50S ribosomal protein L29 RpmC;protein_id=CCP43453.1;transl_table=11
AL123456.3	EMBL	gene	805756	806166	.	+	.	ID=gene-Rv0710;Name=rpsQ;gbkey=Gene;gene=rpsQ;gene_biotype=protein_coding;locus_tag=Rv0710
AL123456.3	EMBL	CDS	805756	806166	.	+	0	ID=cds-CCP43454.1;Parent=gene-Rv0710;Dbxref=EnsemblGenomes-Gn:Rv0710,EnsemblGenomes-Tr:CCP43454,GOA:P9WH51,InterPro:IPR000266,InterPro:IPR012340,InterPro:IPR019979,InterPro:IPR019984,NCBI_GP:CCP43454.1;Name=CCP43454.1;Note=Rv0710%2C (MTCY210.29)%2C len: 136 aa. rpsQ%2C 30S ribosomal protein S17%2C equivalent to O06051|RS17_MYCBO 30S|MBS10OPER_11 30S ribosomal protein S17 from Mycobacterium bovis BCG (136 aa)%3B and MLCB2492_11 30S ribosomal protein S17 from Mycobacterium leprae (126 aa). Also highly similar to others e.g. CAB82079.1|AL161803 30S ribosomal protein S17 from Streptomyces coelicolor (95 aa)%3B P12874|RS17_BACSU 30s ribosomal protein s17 (bs 16) from Bacillus subtilis (86 aa)%2C FASTA scores: opt: 305%2C E(): 1.6e-11%2C (60.5%25 identity in 81 aa overlap)%3B etc. Contains PS00056 Ribosomal protein S17 signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsQ;inference=protein motif:PROSITE:PS00056;locus_tag=Rv0710;product=30S ribosomal protein S17 RpsQ;protein_id=CCP43454.1;transl_table=11
AL123456.3	EMBL	gene	806335	808698	.	+	.	ID=gene-Rv0711;Name=atsA;gbkey=Gene;gene=atsA;gene_biotype=protein_coding;locus_tag=Rv0711
AL123456.3	EMBL	CDS	806335	808698	.	+	0	ID=cds-CCP43455.1;Parent=gene-Rv0711;Dbxref=EnsemblGenomes-Gn:Rv0711,EnsemblGenomes-Tr:CCP43455,GOA:P95059,InterPro:IPR000917,InterPro:IPR017849,InterPro:IPR017850,InterPro:IPR024607,UniProtKB/TrEMBL:P95059,NCBI_GP:CCP43455.1;Name=CCP43455.1;Note=Rv0711%2C (MTCY210.30)%2C len: 787 aa. Possible atsA%2Carylsulfatase%2C similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa)%2C FASTA scores: opt: 439%2C E(): 2.9e-21%2C (30.8%25 identity in 552 aa overlap)%3B etc. Also similar to other hypothetical arylsulfatases from Mycobacterium tuberculosis e.g. Rv3299c%2C Rv0663%2C etc. Contains PS00523 Sulfatases signature 1%2C and PS00149 Sulfatases signature 2. Belongs to the sulfatase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atsA;inference=protein motif:PROSITE:PS00678;locus_tag=Rv0711;product=Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase);protein_id=CCP43455.1;transl_table=11
AL123456.3	EMBL	gene	808746	809645	.	+	.	ID=gene-Rv0712;Name=Rv0712;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0712
AL123456.3	EMBL	CDS	808746	809645	.	+	0	ID=cds-CCP43456.1;Parent=gene-Rv0712;Dbxref=EnsemblGenomes-Gn:Rv0712,EnsemblGenomes-Tr:CCP43456,InterPro:IPR005532,InterPro:IPR016187,UniProtKB/TrEMBL:I6Y8I5,NCBI_GP:CCP43456.1;Name=CCP43456.1;Note=Rv0712%2C (MTCY210.31)%2C len: 299 aa. Conserved protein%2C similar to others e.g. NP_106128.1|NC_002678 hypothetical protein from Mesorhizobium loti (372 aa)%3B D90901_33|P72841 hypothetical 48.1 kDa protein from Synechocystis sp (410 aa)%2C FASTA scores: E(): 1.1e-07%2C(28.8%25 identity in 299 aa overlap)%3B etc. Slight similarity to carboxykinases. Similar to C-terminal part of Rv3703c conserved hypothetical protein from Mycobacterium tuberculosis (425 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0712;product=Conserved protein;protein_id=CCP43456.1;transl_table=11
AL123456.3	EMBL	gene	809946	810887	.	+	.	ID=gene-Rv0713;Name=Rv0713;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0713
AL123456.3	EMBL	CDS	809946	810887	.	+	0	ID=cds-CCP43457.1;Parent=gene-Rv0713;Dbxref=EnsemblGenomes-Gn:Rv0713,EnsemblGenomes-Tr:CCP43457,GOA:I6WZ58,InterPro:IPR027948,UniProtKB/TrEMBL:I6WZ58,NCBI_GP:CCP43457.1;Name=CCP43457.1;Note=Rv0713%2C (MTCY210.32)%2C len: 313 aa. Probable conserved transmembrane protein%2C similar to Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis (284 aa)%2C FASTA scores: opt: 557%2C E(): 2.1e-29%2C (35.8%25 identity in 282 aa overlap)%3B MLCB2492_12|O32991 hypothetical 10.7 kDa protein from Mycobacterium leprae (95 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0713;product=Probable conserved transmembrane protein;protein_id=CCP43457.1;transl_table=11
AL123456.3	EMBL	gene	811373	811741	.	+	.	ID=gene-Rv0714;Name=rplN;gbkey=Gene;gene=rplN;gene_biotype=protein_coding;locus_tag=Rv0714
AL123456.3	EMBL	CDS	811373	811741	.	+	0	ID=cds-CCP43458.1;Parent=gene-Rv0714;Dbxref=EnsemblGenomes-Gn:Rv0714,EnsemblGenomes-Tr:CCP43458,GOA:P9WHD9,InterPro:IPR000218,InterPro:IPR005745,InterPro:IPR019972,InterPro:IPR023571,NCBI_GP:CCP43458.1;Name=CCP43458.1;Note=Rv0714%2C (MTCY210.33)%2C len: 122 aa. rplN%2C 50S ribosomal protein L14%2C equivalent to O32993|MLCB2492_14|ML1849|RL14_MYCLE 50S ribosomal protein L14 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82080.1|AL161803 50S ribosomal protein L14 from Streptomyces coelicolor (122 aa)%3B P33100|RL14_MICLU 50s ribosomal protein L14 from Micrococcus luteus (122 aa)%2C FASTA scores: opt: 674%2C E(): 0%2C (85.2%25 identity in 122 aa overlap)%3B etc. Contains PS00049 Ribosomal protein L14 signature. Belongs to the L14P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplN;inference=protein motif:PROSITE:PS00049;locus_tag=Rv0714;product=50S ribosomal protein L14 RplN;protein_id=CCP43458.1;transl_table=11
AL123456.3	EMBL	gene	811742	812059	.	+	.	ID=gene-Rv0715;Name=rplX;gbkey=Gene;gene=rplX;gene_biotype=protein_coding;locus_tag=Rv0715
AL123456.3	EMBL	CDS	811742	812059	.	+	0	ID=cds-CCP43459.1;Parent=gene-Rv0715;Dbxref=EnsemblGenomes-Gn:Rv0715,EnsemblGenomes-Tr:CCP43459,GOA:P9WHB7,InterPro:IPR003256,InterPro:IPR005824,InterPro:IPR005825,InterPro:IPR008991,InterPro:IPR014722,NCBI_GP:CCP43459.1;Name=CCP43459.1;Note=Rv0715%2C (MTCY210.34)%2C len: 105 aa. rplX%2C 50S ribosomal protein L24%2C equivalent to O32994|MLCB2492_15 50S ribosomal protein L24 from Mycobacterium leprae (105 aa). Also highly similar to others e.g. CAB82081.1|AL161803 50S ribosomal protein L24 from Streptomyces coelicolor (107 aa)%3B P12876|RL24_BACSU 50s ribosomal protein L24 (bl23) from Bacillus subtilis (103 aa)%2C FASTA scores: opt: 363%2CE(): 1.8e-18%2C (56.7%25 identity in 104 aa overlap)%3B etc. Contains PS01108 Ribosomal protein L24 signature. Belongs to the L24P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplX;inference=protein motif:PROSITE:PS01108;locus_tag=Rv0715;product=50S ribosomal protein L24 RplX;protein_id=CCP43459.1;transl_table=11
AL123456.3	EMBL	gene	812059	812622	.	+	.	ID=gene-Rv0716;Name=rplE;gbkey=Gene;gene=rplE;gene_biotype=protein_coding;locus_tag=Rv0716
AL123456.3	EMBL	CDS	812059	812622	.	+	0	ID=cds-CCP43460.1;Parent=gene-Rv0716;Dbxref=EnsemblGenomes-Gn:Rv0716,EnsemblGenomes-Tr:CCP43460,GOA:P9WH83,InterPro:IPR002132,InterPro:IPR020930,InterPro:IPR022803,NCBI_GP:CCP43460.1;Name=CCP43460.1;Note=Rv0716%2C (MTCY210.35)%2C len: 187 aa. rplE%2C 50S ribosomal protein L5%2C equivalent to MLCB2492_16 50S ribosomal protein L5 from Mycobacterium leprae (187 aa). Also highly similar to others e.g. CAB82082.1|AL161803 50S ribosomal protein L5 from Streptomyces coelicolor (185 aa)%3B P33098|RL5_MICLU 50S ribosomal protein L5 from Micrococcus luteus (191 aa)%2C FASTA scores: opt: 930%2C E(): 0%2C (73.8%25 identity in 183 aa overlap)%3B etc. Belongs to the L5P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplE;locus_tag=Rv0716;product=50S ribosomal protein L5 RplE;protein_id=CCP43460.1;transl_table=11
AL123456.3	EMBL	gene	812627	812812	.	+	.	ID=gene-Rv0717;Name=rpsN1;gbkey=Gene;gene=rpsN1;gene_biotype=protein_coding;gene_synonym=rpsN;locus_tag=Rv0717
AL123456.3	EMBL	CDS	812627	812812	.	+	0	ID=cds-CCP43461.1;Parent=gene-Rv0717;Dbxref=EnsemblGenomes-Gn:Rv0717,EnsemblGenomes-Tr:CCP43461,GOA:P9WH57,InterPro:IPR001209,InterPro:IPR018271,InterPro:IPR023053,NCBI_GP:CCP43461.1;Name=CCP43461.1;Note=Rv0717%2C (MTCY210.36)%2C len: 61 aa. rpsN1%2C 30S ribosomal protein S14%2C equivalent to MLCB2492_17|O32996 ribosomal protein S14 from Mycobacterium leprae (61 aa). Also highly similar to others e.g. CAB82083.1|AL161803 30S ribosomal protein S14 from Streptomyces coelicolor (61 aa)%3B P24320|RS14_THETH 30s ribosomal protein S14 from Thermus aquaticus (subsp. thermophilus) (60 aa)%2C FASTA scores: opt: 316%2C E(): 2e-19%2C(70.0%25 identity in 60 aa overlap)%3B etc. Contains PS00527 Ribosomal protein S14 signature. Belongs to the S14P family of ribosomal proteins. Note that previously known as rpsN.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsN1;inference=protein motif:PROSITE:PS00527;locus_tag=Rv0717;product=30S ribosomal protein S14 RpsN1;protein_id=CCP43461.1;transl_table=11
AL123456.3	EMBL	repeat_region	812835	812921	.	+	.	ID=id-AL123456.3:812835..812921;Note=87 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	812922	812975	.	+	.	ID=id-AL123456.3:812922..812975;Note=54 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	812976	813374	.	+	.	ID=gene-Rv0718;Name=rpsH;gbkey=Gene;gene=rpsH;gene_biotype=protein_coding;locus_tag=Rv0718
AL123456.3	EMBL	CDS	812976	813374	.	+	0	ID=cds-CCP43462.1;Parent=gene-Rv0718;Dbxref=EnsemblGenomes-Gn:Rv0718,EnsemblGenomes-Tr:CCP43462,GOA:P9WH27,InterPro:IPR000630,NCBI_GP:CCP43462.1;Name=CCP43462.1;Note=Rv0718%2C (MTCY210.37)%2C len: 132 aa. rpsH%2C 30S ribosomal protein S8%2C equivalent to O32997|MLCB2492_18 30S ribosomal protein S8 from Mycobacterium leprae (132 aa). Also highly similar to others e.g. CAB82084.1|AL161803 30S ribosomal protein S8 from Streptomyces coelicolor (132 aa)%3B P33106|RS8_MICLU 30s ribosomal protein S8 from Micrococcus luteus (132 aa)%2C FASTA scores: opt: 669%2C E(): 0%2C (77.3%25 identity in 132 aa overlap)%3B etc. Contains PS00053 Ribosomal protein S8 signature. Belongs to the S8P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsH;inference=protein motif:PROSITE:PS00053;locus_tag=Rv0718;product=30S ribosomal protein S8 RpsH;protein_id=CCP43462.1;transl_table=11
AL123456.3	EMBL	gene	813398	813937	.	+	.	ID=gene-Rv0719;Name=rplF;gbkey=Gene;gene=rplF;gene_biotype=protein_coding;locus_tag=Rv0719
AL123456.3	EMBL	CDS	813398	813937	.	+	0	ID=cds-CCP43463.1;Parent=gene-Rv0719;Dbxref=EnsemblGenomes-Gn:Rv0719,EnsemblGenomes-Tr:CCP43463,GOA:P9WH81,InterPro:IPR000702,InterPro:IPR002358,InterPro:IPR019906,InterPro:IPR020040,NCBI_GP:CCP43463.1;Name=CCP43463.1;Note=Rv0719%2C (MTCY210.38)%2C len: 179 aa. rplF%2C 50S ribosomal protein L6%2C equivalent to O32998|MLCB2492_19 50S ribosomal protein L6 from Mycobacterium leprae (179 aa). Also highly similar to others e.g. P46786|RL6_STRCO|CAB82085.1|AL161803|SCD31.42 50S ribosomal protein L6 from Streptomyces coelicolor (179 aa)%2C FASTA scores: opt: 872%2C E(): 0%2C (70.4%25 identity in 179 aa overlap)%3B etc. Contains PS00525 Ribosomal protein L6 signature 1. Belongs to the L6P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplF;inference=protein motif:PROSITE:PS00525;locus_tag=Rv0719;product=50S ribosomal protein L6 RplF;protein_id=CCP43463.1;transl_table=11
AL123456.3	EMBL	gene	813940	814308	.	+	.	ID=gene-Rv0720;Name=rplR;gbkey=Gene;gene=rplR;gene_biotype=protein_coding;locus_tag=Rv0720
AL123456.3	EMBL	CDS	813940	814308	.	+	0	ID=cds-CCP43464.1;Parent=gene-Rv0720;Dbxref=EnsemblGenomes-Gn:Rv0720,EnsemblGenomes-Tr:CCP43464,GOA:P9WHD1,InterPro:IPR004389,InterPro:IPR005484,NCBI_GP:CCP43464.1;Name=CCP43464.1;Note=Rv0720%2C (MTCY210.39)%2C len: 122 aa. rplR%2C 50S ribosomal protein L18%2C equivalent to O32999|MLCB2492_20|RL18_MYCLE 50S ribosomal protein L18 from Mycobacterium leprae (122 aa). Also highly similar to others e.g. CAB82086.1|AL161803 50S ribosomal protein L18 from Streptomyces coelicolor (127 aa)%3B P33102|RL18_MICLU 50s ribosomal protein L18 from Micrococcus luteus (119 aa)%2CFASTA scores: opt: 447%2C E(): 8.7e-24%2C (60.4%25 identity in 111 aa overlap)%3B etc. Belongs to the L18P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplR;locus_tag=Rv0720;product=50S ribosomal protein L18 RplR;protein_id=CCP43464.1;transl_table=11
AL123456.3	EMBL	gene	814328	814990	.	+	.	ID=gene-Rv0721;Name=rpsE;gbkey=Gene;gene=rpsE;gene_biotype=protein_coding;locus_tag=Rv0721
AL123456.3	EMBL	CDS	814328	814990	.	+	0	ID=cds-CCP43465.1;Parent=gene-Rv0721;Dbxref=EnsemblGenomes-Gn:Rv0721,EnsemblGenomes-Tr:CCP43465,GOA:P9WH33,InterPro:IPR000851,InterPro:IPR005324,InterPro:IPR005712,InterPro:IPR013810,InterPro:IPR014720,InterPro:IPR014721,InterPro:IPR018192,InterPro:IPR020568,NCBI_GP:CCP43465.1;Name=CCP43465.1;Note=Rv0721%2C (MTCY210.40)%2C len: 220 aa. rpsE%2C 30S ribosomal protein S5%2C equivalent to MLCB2492_21 ribosomal protein S5 from Mycobacterium leprae (217 aa). Also highly similar to others e.g. P46790|RS5_STRCO 30s ribosomal protein S5 from Streptomyces coelicolor (167 aa)%2C FASTA scores: opt: 889%2C E(): 0%2C (82.1%25 identity in 162 aa overlap)%3B etc. Note N-terminus is extented compared to other rpsE genes. Contains PS00585 Ribosomal protein S5 signature%2C PTS HPr component phosphorylation sites signature. Belongs to the S5P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsE;inference=protein motif:PROSITE:PS00589;locus_tag=Rv0721;product=30S ribosomal protein S5 RpsE;protein_id=CCP43465.1;transl_table=11
AL123456.3	EMBL	gene	814993	815190	.	+	.	ID=gene-Rv0722;Name=rpmD;gbkey=Gene;gene=rpmD;gene_biotype=protein_coding;locus_tag=Rv0722
AL123456.3	EMBL	CDS	814993	815190	.	+	0	ID=cds-CCP43466.1;Parent=gene-Rv0722;Dbxref=EnsemblGenomes-Gn:Rv0722,EnsemblGenomes-Tr:CCP43466,GOA:P9WHA3,InterPro:IPR005996,InterPro:IPR016082,InterPro:IPR018038,NCBI_GP:CCP43466.1;Name=CCP43466.1;Note=Rv0722%2C (MTCY210.41)%2C len: 65 aa. rpmD%2C 50S ribosomal protein L30%2C equivalent to O33001 ribosomal protein L30 from Mycobacterium leprae (71 aa). Also highly similar to others e.g. P46789|RL30_STRCO 50S ribosomal protein L30 from Streptomyces coelicolor (60 aa)%3B P02430|RL30_ECOLI 50S ribosomal protein L30 from Escherichia coli (58 aa)%2C FASTA scores: opt: 168%2C E(): 1.5e-13%2C (53.7%25 identity in 54 aa overlap)%3B etc. Belongs to the L30P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpmD;locus_tag=Rv0722;product=50S ribosomal protein L30 RpmD;protein_id=CCP43466.1;transl_table=11
AL123456.3	EMBL	gene	815190	815630	.	+	.	ID=gene-Rv0723;Name=rplO;gbkey=Gene;gene=rplO;gene_biotype=protein_coding;locus_tag=Rv0723
AL123456.3	EMBL	CDS	815190	815630	.	+	0	ID=cds-CCP43467.1;Parent=gene-Rv0723;Dbxref=EnsemblGenomes-Gn:Rv0723,EnsemblGenomes-Tr:CCP43467,GOA:P9WHD7,InterPro:IPR001196,InterPro:IPR005749,InterPro:IPR021131,NCBI_GP:CCP43467.1;Name=CCP43467.1;Note=Rv0723%2C (MTCY210.42)%2C len: 146 aa. rplO%2C 50S ribosomal protein L15%2C equivalent to MLCB2492_23|O33002 50S ribosomal protein L15 from Mycobacterium leprae (146 aa). Also highly similar to others e.g. P46787|RL15_STRCO|SCD31.46 50S ribosomal protein L15 from Streptomyces coelicolor (151 aa)%3B P19946|RL15_BACSU 50s ribosomal protein L15 from Bacillus subtilis (146 aa)%2CFASTA scores: opt: 419%2C E(): 6.5e-20%2C (51.0%25 identity in 145 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00475 Ribosomal protein L15 signature. Belongs to the L15P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplO;inference=protein motif:PROSITE:PS00475;locus_tag=Rv0723;product=50S ribosomal protein L15 RplO;protein_id=CCP43467.1;transl_table=11
AL123456.3	EMBL	gene	815663	817534	.	+	.	ID=gene-Rv0724;Name=sppA;gbkey=Gene;gene=sppA;gene_biotype=protein_coding;locus_tag=Rv0724
AL123456.3	EMBL	CDS	815663	817534	.	+	0	ID=cds-CCP43468.1;Parent=gene-Rv0724;Dbxref=EnsemblGenomes-Gn:Rv0724,EnsemblGenomes-Tr:CCP43468,GOA:P95072,InterPro:IPR002142,InterPro:IPR004634,InterPro:IPR004635,InterPro:IPR029045,UniProtKB/TrEMBL:P95072,NCBI_GP:CCP43468.1;Name=CCP43468.1;Note=Rv0724%2C (MTCY210.43)%2C len: 623 aa. Possible sppA%2Cprotease IV (endopeptidase IV)%2C equivalent (but longer 23 aa) to MLCB2492_24|O33003 endopeptidase IV from Mycobacterium leprae (602 aa). Also similar to others e.g. NP_419743.1|NC_002696 signal peptide peptidase SppA from Caulobacter crescentus (594 aa)%3B P08395|SPPA_ECOLI|B1766 protease IV (endopeptidase) from Escherichia coli strain K-12 (618 aa)%2C FASTA scores: opt: 582%2C E(): 8.9e-27%2C (34.1%25 identity in 525 aa overlap)%3B etc. Belongs to peptidase family S49. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sppA;locus_tag=Rv0724;product=Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase);protein_id=CCP43468.1;transl_table=11
AL123456.3	EMBL	gene	817531	817866	.	-	.	ID=gene-Rv0724A;Name=Rv0724A;end_range=817866,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0724A;partial=true
AL123456.3	EMBL	CDS	817531	817866	.	-	0	ID=cds-CCP43469.1;Parent=gene-Rv0724A;Dbxref=EnsemblGenomes-Gn:Rv0724A,EnsemblGenomes-Tr:CCP43469,GOA:Q79FX1,InterPro:IPR007213,InterPro:IPR029063,UniProtKB/TrEMBL:Q79FX1,NCBI_GP:CCP43469.1;Name=CCP43469.1;Note=Rv0724A%2C len: 111 aa. Similarity suggests that this CDS should be continuation of Rv0725c but we can find no frame-shift to account for this. Possible extended protein is very similar to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv1729c|Z81360_12 (312 aa)%2CFASTA scores: opt: 399%2C E(): 2e-19%2C (58.7%25 identity in 109 aa overlap)%3B Rv0731c%2C Rv0726c%2C etc. Frame-shift could occur at nt 817866. Same sequence for strain CDC1551 and Mycobacterium bovis.;end_range=817866,.;gbkey=CDS;locus_tag=Rv0724A;partial=true;product=Conserved hypothetical protein;protein_id=CCP43469.1;transl_table=11
AL123456.3	EMBL	gene	817539	818444	.	-	.	ID=gene-Rv0725c;Name=Rv0725c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0725c
AL123456.3	EMBL	CDS	817539	818444	.	-	0	ID=cds-CCP43470.1;Parent=gene-Rv0725c;Dbxref=EnsemblGenomes-Gn:Rv0725c,EnsemblGenomes-Tr:CCP43470,GOA:P95073,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,UniProtKB/TrEMBL:P95073,NCBI_GP:CCP43470.1;Name=CCP43470.1;Note=Rv0725c%2C (MTCY210.44c)%2C len: 301 aa. Conserved hypothetical protein%2C similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0726c%2C Rv0731c%2C Rv3399%2Cetc%2C e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical 36.1 kDa protein cy31.21c (325 aa)%2C FASTA scores: opt: 600%2C E(): 3.9e-32%2C (43.8%25 identity in 219 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0725c;product=Conserved hypothetical protein;protein_id=CCP43470.1;transl_table=11
AL123456.3	EMBL	gene	818537	819640	.	-	.	ID=gene-Rv0726c;Name=Rv0726c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0726c
AL123456.3	EMBL	CDS	818537	819640	.	-	0	ID=cds-CCP43471.1;Parent=gene-Rv0726c;Dbxref=EnsemblGenomes-Gn:Rv0726c,EnsemblGenomes-Tr:CCP43471,GOA:P9WFI7,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP43471.1;Name=CCP43471.1;Note=Rv0726c%2C (MTCY210.45c)%2C len: 367 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C highly similar to other proteins from Mycobacterium tuberculosis e.g. Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa)%2C FASTA scores: opt: 646%2C E(): 0%2C (38.3%25 identity in 329 aa overlap)%3B Rv0731c|MTV041.05c (318 aa)%2C Rv3399%2C etc. Also similar to proteins from Mycobacterium leprae and other organisms e.g. T35930 hypothetical protein SC9B5.10 from Streptomyces coelicolor (303 aa).;gbkey=CDS;locus_tag=Rv0726c;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP43471.1;transl_table=11
AL123456.3	EMBL	gene	819843	820499	.	-	.	ID=gene-Rv0727c;Name=fucA;gbkey=Gene;gene=fucA;gene_biotype=protein_coding;locus_tag=Rv0727c
AL123456.3	EMBL	CDS	819843	820499	.	-	0	ID=cds-CCP43472.1;Parent=gene-Rv0727c;Dbxref=EnsemblGenomes-Gn:Rv0727c,EnsemblGenomes-Tr:CCP43472,InterPro:IPR001303,UniProtKB/TrEMBL:P95075,NCBI_GP:CCP43472.1;Name=CCP43472.1;Note=Rv0727c%2C (MTV41.01c%2C MTCY210.46c)%2C len: 218 aa. Possible fucA%2C L-fuculose-1-phosphate aldolase%2C similar to many e.g. NP_386339.1|NC_003047 putative L-fuculose phosphate aldolase protein from Sinorhizobium meliloti (222 aa)%3B P11550|FUCA_ECOLI L-fuculose phosphate aldolase from Escherichia strain K12 (215 aa)%2C FASTA scores: opt: 372%2CE(): 4.1e-19%2C (34.6%25 identity in 185 aa overlap)%3B etc. Belongs to the aldolase class II family%2C ARAD/FUCA subfamily. Cofactor: binds one zinc ion per molecule.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fucA;locus_tag=Rv0727c;product=Possible L-fuculose phosphate aldolase FucA (L-fuculose-1-phosphate aldolase);protein_id=CCP43472.1;transl_table=11
AL123456.3	EMBL	gene	820496	821476	.	-	.	ID=gene-Rv0728c;Name=serA2;gbkey=Gene;gene=serA2;gene_biotype=protein_coding;locus_tag=Rv0728c
AL123456.3	EMBL	CDS	820496	821476	.	-	0	ID=cds-CCP43473.1;Parent=gene-Rv0728c;Dbxref=EnsemblGenomes-Gn:Rv0728c,EnsemblGenomes-Tr:CCP43473,GOA:I6WZ71,InterPro:IPR006139,InterPro:IPR006140,InterPro:IPR016040,UniProtKB/TrEMBL:I6WZ71,NCBI_GP:CCP43473.1;Name=CCP43473.1;Note=Rv0728c%2C (MTV041.02c)%2C len: 326 aa. Possible serA2%2CD-3-phosphoglycerate dehydrogenase%2C similar to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (344 aa)%2C FASTA scores: opt: 594%2CE(): 3.1e-31%2C (35.9%25 identity in 309 aa overlap)%3B etc. Also similar to Rv2996c|MTV012.10|SERA1 D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis (528 aa).;gbkey=CDS;gene=serA2;locus_tag=Rv0728c;product=Possible D-3-phosphoglycerate dehydrogenase SerA2 (phosphoglycerate dehydrogenase) (PGDH);protein_id=CCP43473.1;transl_table=11
AL123456.3	EMBL	gene	821507	822853	.	+	.	ID=gene-Rv0729;Name=xylB;gbkey=Gene;gene=xylB;gene_biotype=protein_coding;locus_tag=Rv0729
AL123456.3	EMBL	CDS	821507	822853	.	+	0	ID=cds-CCP43474.1;Parent=gene-Rv0729;Dbxref=EnsemblGenomes-Gn:Rv0729,EnsemblGenomes-Tr:CCP43474,GOA:I6Y4K0,InterPro:IPR018484,InterPro:IPR018485,UniProtKB/TrEMBL:I6Y4K0,NCBI_GP:CCP43474.1;Name=CCP43474.1;Note=Rv0729%2C (MTV041.03)%2C len: 448 aa. Possible xylB%2CD-xylulose-kinase (xylulokinase). C-terminus highly similar to AAD09880.1|U77912 unknown protein from Mycobacterium bovis (102 aa)%3B and N-terminus highly similar to T45387|Z98756|MLCB2492_25 hypothetical protein from Mycobacterium leprae (110 aa)%2C FASTA scores: opt: 427%2C E(): 1.1e-19%2C (60.9%25 identity in 110 aa overlap). Also similar to xylA/xylB genes from various bacterial species e.g. AAC26499.1|AF045245 D-xylulose-kinase from Klebsiella pneumoniae (487 aa)%3B NP_418021.1|NC_000913 xylulokinase from Escherichia coli strain K12 (484 aa)%2C FASTA scores: opt: 260%2C E(): 7.5e-09%2C (25.9%25 identity in 478 aa overlap)%3B etc. Also similar to Rv3696c|glpK probable glycerol kinase from Mycobacterium tuberculosis (517 aa). Belongs to the fucokinase / gluconokinase / glycerokinase / xylulokinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=xylB;locus_tag=Rv0729;product=Possible D-xylulose kinase XylB (xylulokinase) (xylulose kinase);protein_id=CCP43474.1;transl_table=11
AL123456.3	EMBL	gene	822866	823594	.	+	.	ID=gene-Rv0730;Name=Rv0730;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0730
AL123456.3	EMBL	CDS	822866	823594	.	+	0	ID=cds-CCP43475.1;Parent=gene-Rv0730;Dbxref=EnsemblGenomes-Gn:Rv0730,EnsemblGenomes-Tr:CCP43475,GOA:I6XW38,InterPro:IPR000182,InterPro:IPR013760,InterPro:IPR016181,UniProtKB/TrEMBL:I6XW38,NCBI_GP:CCP43475.1;Name=CCP43475.1;Note=Rv0730%2C (MTV041.04)%2C len: 242 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005. Equivalent to Z98756|MLCB2492_26 hypothetical protein from Mycobacterium leprae (227 aa)%2C FASTA scores: opt: 1180%2C E(): 0%2C (83.5%25 identity in 218 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0730;product=GCN5-related N-acetyltransferase;protein_id=CCP43475.1;transl_table=11
AL123456.3	EMBL	gene	823683	824639	.	-	.	ID=gene-Rv0731c;Name=Rv0731c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0731c
AL123456.3	EMBL	CDS	823683	824639	.	-	0	ID=cds-CCP43476.1;Parent=gene-Rv0731c;Dbxref=EnsemblGenomes-Gn:Rv0731c,EnsemblGenomes-Tr:CCP43476,GOA:P9WFI5,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP43476.1;Name=CCP43476.1;Note=Rv0731c%2C (MTV041.05c)%2C len: 318 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C highly similar to other proteins from Mycobacterium tuberculosis e.g. Rv0726c|MTCY210.45c (367 aa)%2C FASTA score: (60.9%25 identity in 317 aa overlap)%3B Rv3399%2C Rv1729c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0731c;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP43476.1;transl_table=11
AL123456.3	EMBL	gene	824800	826125	.	+	.	ID=gene-Rv0732;Name=secY;gbkey=Gene;gene=secY;gene_biotype=protein_coding;locus_tag=Rv0732
AL123456.3	EMBL	CDS	824800	826125	.	+	0	ID=cds-CCP43477.1;Parent=gene-Rv0732;Dbxref=EnsemblGenomes-Gn:Rv0732,EnsemblGenomes-Tr:CCP43477,GOA:P9WGN3,InterPro:IPR002208,InterPro:IPR023201,InterPro:IPR026593,NCBI_GP:CCP43477.1;Name=CCP43477.1;Note=Rv0732%2C (MTV041.06)%2C len: 441 aa. Probable SecY%2Cpreprotein translocase (integral membrane protein) (see citation below)%2C equivalent to NP_302243.1|NC_002677 SecY subunit of preprotein translocase from Mycobacterium leprae (438 aa)%3B AAC04389.1|AF047021 preprotein translocase subunit from Mycobacterium smegmatis (438 aa)%3B and U77912|MBU77912_1 preprotein translocase subunit from Mycobacterium bovis (441 aa)%2C FASTA scores: opt: 2802%2C E(): 0%2C (99.8%25 identity in 441 aa overlap). Also highly similar to others e.g. P46785|SECY_STRCO preprotein translocase SECY subunit from Streptomyces coelicolor (437 aa)%3B etc. Contains PS00755 and PS00756 protein secY signatures 1 and 2. Belongs to the SECE/SEC61-alpha family. Part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c%2C SECD|Rv2587c%2C SECE|Rv0638%2C SECF|Rv2586c%2CSECG|Rv1440 and SECY.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=secY;inference=protein motif:PROSITE:PS00756;locus_tag=Rv0732;product=Probable preprotein translocase SecY;protein_id=CCP43477.1;transl_table=11
AL123456.3	EMBL	gene	826122	826667	.	+	.	ID=gene-Rv0733;Name=adk;gbkey=Gene;gene=adk;gene_biotype=protein_coding;locus_tag=Rv0733
AL123456.3	EMBL	CDS	826122	826667	.	+	0	ID=cds-CCP43478.1;Parent=gene-Rv0733;Dbxref=EnsemblGenomes-Gn:Rv0733,EnsemblGenomes-Tr:CCP43478,GOA:P9WKF5,InterPro:IPR000850,InterPro:IPR027417,PDB:1P4S,PDB:2CDN,NCBI_GP:CCP43478.1;Name=CCP43478.1;Note=Rv0733%2C (MTV041.07)%2C len: 181 aa. adk%2C adenylate kinase (ATP-AMP transphosphorylase)%2C equivalent to Z98756|MLCB24 92_28 probable adenylate kinase from Mycobacterium leprae (181 aa)%2C FASTA scores: opt: 978%2C E(): 0%2C (83.6%25 identity in 177 aa overlap)%3B and AAF86323.1|AF271342 putative adenylate kinase from Mycobacterium marinum (124 aa) (N-terminus shorter). Also highly similar to others e.g. P43414|KAD_STRCO adenylate kinase from Streptomyces coelicolor (217 aa)%2C FASTA score: (43.0%25 identity in 186 aa overlap)%3B etc. Contains PS00113 Adenylate kinase signature. Belongs to the adenylate kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adk;inference=protein motif:PROSITE:PS00113;locus_tag=Rv0733;product=Adenylate kinase Adk (ATP-AMP transphosphorylase);protein_id=CCP43478.1;transl_table=11
AL123456.3	EMBL	gene	826670	827470	.	+	.	ID=gene-Rv0734;Name=mapA;gbkey=Gene;gene=mapA;gene_biotype=protein_coding;gene_synonym=map;locus_tag=Rv0734
AL123456.3	EMBL	CDS	826670	827470	.	+	0	ID=cds-CCP43479.1;Parent=gene-Rv0734;Dbxref=EnsemblGenomes-Gn:Rv0734,EnsemblGenomes-Tr:CCP43479,GOA:P9WK21,InterPro:IPR000994,InterPro:IPR001714,InterPro:IPR002467,NCBI_GP:CCP43479.1;Name=CCP43479.1;Note=Rv0734%2C (MTV041.08)%2C len: 266 aa. mapA%2C methionine aminopeptidase (map)%2C equivalent to Z98756|MLCB2492_29 probable methionine aminopeptidase from Mycobacterium leprae (266 aa)%2C FASTA scores: opt: 1717%2C E(): 0%2C (83.4%25 identity in 265 aa overlap). Also highly similar to many e.g. T35553 methionine aminopeptidase from Streptomyces coelicolor (278 aa)%3B etc. Also similar to Rv2861c|MAPB probable methionine aminopeptidase from Mycobacterium tuberculosis (285 aa). Belongs to peptidase family M24A%3B also known as the map family 1. Cofactor: cobalt%3B binds 2 ions per subunit. Conserved in M. tuberculosis%2C M. leprae%2CM. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mapA;locus_tag=Rv0734;product=Methionine aminopeptidase MapA (map) (peptidase M) (MetAP);protein_id=CCP43479.1;transl_table=11
AL123456.3	EMBL	gene	827543	828076	.	+	.	ID=gene-Rv0735;Name=sigL;gbkey=Gene;gene=sigL;gene_biotype=protein_coding;locus_tag=Rv0735
AL123456.3	EMBL	CDS	827543	828076	.	+	0	ID=cds-CCP43480.1;Parent=gene-Rv0735;Dbxref=EnsemblGenomes-Gn:Rv0735,EnsemblGenomes-Tr:CCP43480,GOA:P9WGH5,InterPro:IPR000838,InterPro:IPR007627,InterPro:IPR007630,InterPro:IPR011991,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,PDB:3HUG,NCBI_GP:CCP43480.1;Name=CCP43480.1;Note=Rv0735%2C (MTV041.09)%2C len: 177 aa. Probable sigL%2Calternative RNA polymerase sigma factor (rpoE) (see citations below)%2C highly similar to many proteins of the extracytoplasmatic function (ECF) subfamily e.g. CAB72200.1|AL138851 putative RNA polymerase sigma factor from Streptomyces coelicolor (194 aa)%3B Q06909|CARQ_MYXXA RNA polymerase sigma factor CARQ from Myxococcus xanthus (174 aa)%2C FASTA scores: opt: 251%2C E(): 9.6e-11%2C (32.9%25 identity in 161 aa overlap)%3B etc. Also similar to MTCI61_4%2CMTU87242_1%2C and MLU15180_30 from Mycobacterium tuberculosis. Contains PS01063 Sigma-70 factors ECF subfamily signature and probable helix-turn helix motif from aa 139-160 (Score 1134%2C +3.05 SD). Belongs to the sigma-70 factor family%2C ECF subfamily.;gbkey=CDS;gene=sigL;inference=protein motif:PROSITE:PS01063;locus_tag=Rv0735;product=Probable alternative RNA polymerase sigma factor SigL;protein_id=CCP43480.1;transl_table=11
AL123456.3	EMBL	gene	828140	828892	.	+	.	ID=gene-Rv0736;Name=rslA;gbkey=Gene;gene=rslA;gene_biotype=protein_coding;locus_tag=Rv0736
AL123456.3	EMBL	CDS	828140	828892	.	+	0	ID=cds-CCP43481.1;Parent=gene-Rv0736;Dbxref=EnsemblGenomes-Gn:Rv0736,EnsemblGenomes-Tr:CCP43481,GOA:P9WJ67,InterPro:IPR027383,PDB:3HUG,NCBI_GP:CCP43481.1;Name=CCP43481.1;Note=Rv0736%2C (MTV041.10)%2C len: 250 aa. RslA%2C anti-sigma factor (See Dainese et al.%2C 2006). Probable membrane protein%2C showing weak similarity with AL133469|SCM10_32 putative membrane protein from Streptomyces coelicolor (216 aa)%2C FASTA scores: opt: 180%2C E(): 0.00018%2C (34.3%25 identity in 216 aa overlap). Cleaved by Rip|Rv2869c%2C in M. tuberculosis Erdman (See Sklar et al.%2C 2010).;gbkey=CDS;gene=rslA;locus_tag=Rv0736;product=Anti-sigma factor RslA;protein_id=CCP43481.1;transl_table=11
AL123456.3	EMBL	gene	829207	829704	.	+	.	ID=gene-Rv0737;Name=Rv0737;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0737
AL123456.3	EMBL	CDS	829207	829704	.	+	0	ID=cds-CCP43482.1;Parent=gene-Rv0737;Dbxref=EnsemblGenomes-Gn:Rv0737,EnsemblGenomes-Tr:CCP43482,GOA:I6Y8K3,InterPro:IPR000835,InterPro:IPR011991,UniProtKB/TrEMBL:I6Y8K3,NCBI_GP:CCP43482.1;Name=CCP43482.1;Note=Rv0737%2C (MTV041.11)%2C len: 165 aa. Possible transcriptional regulator%2C similar to others e.g. BAB69161.1|AB070937 regulator protein from Streptomyces avermitilis (169 aa)%3B NP_419731.1|NC_002696 transcriptional regulator MarR family from Caulobacter crescentus (148 aa) (homology only at C-terminus)%3B etc. Also shows weak similarity to AB0014|AB001488_14 hypothetical protein from Bacillus subtilis (164 aa)%2C FASTA scores: opt: 163%2C E(): 9.3e-05%2C (32.8%25 identity in 116 aa overlap)%2C which is similar to slyY gene of S. typhimurium required for survival in macrophage. Contains possible helix-turn helix motif from aa 73-94 (Score 1138%2C +3.06 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0737;product=Possible transcriptional regulatory protein;protein_id=CCP43482.1;transl_table=11
AL123456.3	EMBL	gene	830062	830610	.	+	.	ID=gene-Rv0738;Name=Rv0738;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0738
AL123456.3	EMBL	CDS	830062	830610	.	+	0	ID=cds-CCP43483.1;Parent=gene-Rv0738;Dbxref=EnsemblGenomes-Gn:Rv0738,EnsemblGenomes-Tr:CCP43483,GOA:P9WKS3,InterPro:IPR017517,InterPro:IPR017520,InterPro:IPR024344,NCBI_GP:CCP43483.1;Name=CCP43483.1;Note=Rv0738%2C (MTV041.12)%2C len: 182 aa. Conserved protein%2Cshowing weak similarity with hypothetical proteins from Mycobacterium tuberculosis: Rv1727|MTCY04C12.12 (189 aa)%3B MTY13D12_7|Z80343 hypothetical protein from Mycobacterium tuberculosis (194 aa)%2C FASTA scores: opt: 172%2C E(): 0.0004%2C(24.2%25 identity in 178 aa overlap)%3B and C-terminus of Rv0576.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0738;product=Conserved protein;protein_id=CCP43483.1;transl_table=11
AL123456.3	EMBL	gene	830855	831661	.	+	.	ID=gene-Rv0739;Name=Rv0739;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0739
AL123456.3	EMBL	CDS	830855	831661	.	+	0	ID=cds-CCP43484.1;Parent=gene-Rv0739;Dbxref=EnsemblGenomes-Gn:Rv0739,EnsemblGenomes-Tr:CCP43484,GOA:P9WKS1,InterPro:IPR019710,NCBI_GP:CCP43484.1;Name=CCP43484.1;Note=Rv0739%2C (MTV041.13)%2C len: 268 aa. Conserved hypothetical protein%2C showing some similarity to Mycobacterium tuberculosis proteins Rv0026 (448 aa)%2C FASTA score: (37.6%25 identity in 101 aa overlap)and Rv0025 (120 aa)%2C FASTA score: (32.4%25 identity in 142 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0739;product=Conserved hypothetical protein;protein_id=CCP43484.1;transl_table=11
AL123456.3	EMBL	gene	831776	832303	.	+	.	ID=gene-Rv0740;Name=Rv0740;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0740
AL123456.3	EMBL	CDS	831776	832303	.	+	0	ID=cds-CCP43485.1;Parent=gene-Rv0740;Dbxref=EnsemblGenomes-Gn:Rv0740,EnsemblGenomes-Tr:CCP43485,UniProtKB/TrEMBL:O53803,NCBI_GP:CCP43485.1;Name=CCP43485.1;Note=Rv0740%2C (MTV041.14)%2C len: 175 aa. Conserved hypothetical protein%3B C-terminus (possibly part of truncated IS1557) shows nearly perfect identity to Rv0750|MTV041_24 (81 aa)%2C FASTA score: (92.6%25 identity in 81 aa overlap). Also shows weak similarity to MTV007_5 hypothetical protein from Mycobacterium tuberculosis (313 aa)%2C FASTA score: (34.5%25 identity in 110 aa overlap)%3B and MLCL536_27 hypothetical protein from Mycobacterium leprae (315 aa)%2C FASTA score: (34.5%25 identity in 84 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0740;product=Conserved hypothetical protein;protein_id=CCP43485.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	832352	832868	.	+	.	ID=id-AL123456.3:832352..832868;Note=IS1557'-1%2C len: 517 nt. Region similar to Insertion sequence IS1557 on MTCY373- (IS1557- 1st copy). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1557'-1
AL123456.3	EMBL	gene	832534	832848	.	+	.	ID=gene-Rv0741;Name=Rv0741;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0741
AL123456.3	EMBL	CDS	832534	832848	.	+	0	ID=cds-CCP43486.1;Parent=gene-Rv0741;Dbxref=EnsemblGenomes-Gn:Rv0741,EnsemblGenomes-Tr:CCP43486,GOA:I6X9N4,InterPro:IPR002560,UniProtKB/TrEMBL:I6X9N4,NCBI_GP:CCP43486.1;Name=CCP43486.1;Note=Rv0741%2C (MTV041.15)%2C len: 104 aa. Probable truncated transposase for IS1557%2C showing similarity to transposases and is elements e.g. U63997|EFU63997_1 insertion sequence from Enterococcus faecium (424 aa)%2C FASTA score: (31.0%25 identity in 87 aa overlap). Very high similarity with the C-terminal part of Z73419|MTCY373_3 2 IS1557 from Mycobacterium tuberculosis (444 aa)%2C FASTA score: (86.5%25 identity in 104 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0741;product=Probable transposase (fragment);protein_id=CCP43486.1;transl_table=11
AL123456.3	EMBL	gene	832981	833508	.	+	.	ID=gene-Rv0742;Name=PE_PGRS8;gbkey=Gene;gene=PE_PGRS8;gene_biotype=protein_coding;locus_tag=Rv0742
AL123456.3	EMBL	CDS	832981	833508	.	+	0	ID=cds-CCP43487.1;Parent=gene-Rv0742;Dbxref=EnsemblGenomes-Gn:Rv0742,EnsemblGenomes-Tr:CCP43487,InterPro:IPR000084,UniProtKB/TrEMBL:I6Y8K5,NCBI_GP:CCP43487.1;Name=CCP43487.1;Note=Rv0742%2C (MTV041.16)%2C len: 175 aa. PE_PGRS8%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C similar to many Mycobacterium tuberculosis PGRS-type proteins e.g. Z78020|MTCY1A11_25 (498 aa)%2C FASTA scores: opt: 766%2C E(): 6.1e-25%2C (73.6%25 identity in 178 aa overlap). Similarity suggests ORF starts with ATA start codon. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=PE_PGRS8;locus_tag=Rv0742;product=PE-PGRS family protein PE_PGRS8;protein_id=CCP43487.1;transl_table=11
AL123456.3	EMBL	gene	833886	834443	.	-	.	ID=gene-Rv0743c;Name=Rv0743c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0743c
AL123456.3	EMBL	CDS	833886	834443	.	-	0	ID=cds-CCP43488.1;Parent=gene-Rv0743c;Dbxref=EnsemblGenomes-Gn:Rv0743c,EnsemblGenomes-Tr:CCP43488,UniProtKB/TrEMBL:I6WZ83,NCBI_GP:CCP43488.1;Name=CCP43488.1;Note=Rv0743c%2C (MTV041.17c)%2C len: 185 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0743c;product=Hypothetical protein;protein_id=CCP43488.1;transl_table=11
AL123456.3	EMBL	gene	834440	834946	.	-	.	ID=gene-Rv0744c;Name=Rv0744c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0744c
AL123456.3	EMBL	CDS	834440	834946	.	-	0	ID=cds-CCP43489.1;Parent=gene-Rv0744c;Dbxref=EnsemblGenomes-Gn:Rv0744c,EnsemblGenomes-Tr:CCP43489,GOA:O53807,InterPro:IPR009061,InterPro:IPR010093,UniProtKB/TrEMBL:O53807,NCBI_GP:CCP43489.1;Name=CCP43489.1;Note=Rv0744c%2C (MTV041.18c)%2C len: 168 aa. Possible transcriptional regulator%2C showing weak similarity with O86661|SC4A2.05 putative two-component sensor from Streptomyces coelicolor (436 aa)%2C FASTA scores: opt: 117%2CE(): 0.88%2C (37.25%25 identity in 94 aa overlap)%3B and some putative excisionases or transposases. Also weakly similar to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c conserved hypothetical protein from Mycobacterium tuberculosis (114 aa)%3B and Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 conserved hypothetical protein from Mycobacterium tuberculosis (148 aa). Equivalent to AAK45006 from Mycobacterium tuberculosis strain CDC1551 (179 aa) but shorter 11 aa. Contains probable helix-turn helix motif from aa 5-26 (Score 1350%2C +3.78 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0744c;product=Possible transcriptional regulatory protein;protein_id=CCP43489.1;transl_table=11
AL123456.3	EMBL	gene	835154	835681	.	+	.	ID=gene-Rv0745;Name=Rv0745;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0745
AL123456.3	EMBL	CDS	835154	835681	.	+	0	ID=cds-CCP43490.1;Parent=gene-Rv0745;Dbxref=EnsemblGenomes-Gn:Rv0745,EnsemblGenomes-Tr:CCP43490,UniProtKB/TrEMBL:I6X9N8,NCBI_GP:CCP43490.1;Name=CCP43490.1;Note=Rv0745%2C (MTV041.19)%2C len: 175 aa. Conserved hypothetical protein%3B shows high similarity to a 50 aa region of Rv3649|Z95436|MTY15C10_3 conserved hypothetical protein%2C similar to ATP-dependent helicases%2C from Mycobacterium tuberculosis (771 aa)%2C FASTA scores: opt: 225%2C E(): 7e-06%2C (70.0%25 identity in 50 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0745;product=Conserved hypothetical protein;protein_id=CCP43490.1;transl_table=11
AL123456.3	EMBL	gene	835701	838052	.	+	.	ID=gene-Rv0746;Name=PE_PGRS9;gbkey=Gene;gene=PE_PGRS9;gene_biotype=protein_coding;locus_tag=Rv0746
AL123456.3	EMBL	CDS	835701	838052	.	+	0	ID=cds-CCP43491.1;Parent=gene-Rv0746;Dbxref=EnsemblGenomes-Gn:Rv0746,EnsemblGenomes-Tr:CCP43491,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FW8,NCBI_GP:CCP43491.1;Name=CCP43491.1;Note=Rv0746%2C (MTV041.20)%2C len: 783 aa. PE_PGRS9%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa)%2C FASTA scores: opt: 2429%2C E(): 0%2C(56.9%25 identity in 873 aa overlap). Also similar to other PE-PGRS family proteins e.g. AL0212|MTV008_46 FASTA score: (48.8%25 identity in 887 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS9;locus_tag=Rv0746;product=PE-PGRS family protein PE_PGRS9;protein_id=CCP43491.1;transl_table=11
AL123456.3	EMBL	gene	838451	840856	.	+	.	ID=gene-Rv0747;Name=PE_PGRS10;gbkey=Gene;gene=PE_PGRS10;gene_biotype=protein_coding;locus_tag=Rv0747
AL123456.3	EMBL	CDS	838451	840856	.	+	0	ID=cds-CCP43492.1;Parent=gene-Rv0747;Dbxref=EnsemblGenomes-Gn:Rv0747,EnsemblGenomes-Tr:CCP43492,InterPro:IPR000084,NCBI_GP:CCP43492.1;Name=CCP43492.1;Note=Rv0747%2C (MTV041.21)%2C len: 801 aa. PE_PGRS10%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to part of MTCY28.25c|Rv1759c|Z95890 antigen wag22 from M. tuberculosis (914 aa)%2C FASTA scores: opt: 2772%2C E(): 0%2C(60.9%25 identity in 941 aa overlap). Also similar to other PE-PGRS family proteins e.g. Z95844|MTCY493_2 FASTA score: (50.2%25 identity in 815 aa overlap). Contains PS00012 Phosphopantetheine attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS10;inference=protein motif:PROSITE:PS00012;locus_tag=Rv0747;product=PE-PGRS family protein PE_PGRS10;protein_id=CCP43492.1;transl_table=11
AL123456.3	EMBL	gene	840947	841204	.	+	.	ID=gene-Rv0748;Name=vapB31;gbkey=Gene;gene=vapB31;gene_biotype=protein_coding;locus_tag=Rv0748
AL123456.3	EMBL	CDS	840947	841204	.	+	0	ID=cds-CCP43493.1;Parent=gene-Rv0748;Dbxref=EnsemblGenomes-Gn:Rv0748,EnsemblGenomes-Tr:CCP43493,GOA:O53811,InterPro:IPR002145,NCBI_GP:CCP43493.1;Name=CCP43493.1;Note=Rv0748%2C (MTV041.22)%2C len: 85 aa. Possible vapB31%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0749%2Csee Arcus et al. 2005. Also similar to others in Mycobacterium tuberculosis proteins e.g. Rv2871 (75 aa)%3B Rv1241%2C Rv2132%2C Rv3321c%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=vapB31;locus_tag=Rv0748;product=Possible antitoxin VapB31;protein_id=CCP43493.1;transl_table=11
AL123456.3	EMBL	gene	841228	841656	.	+	.	ID=gene-Rv0749;Name=vapC31;gbkey=Gene;gene=vapC31;gene_biotype=protein_coding;locus_tag=Rv0749
AL123456.3	EMBL	CDS	841228	841656	.	+	0	ID=cds-CCP43494.1;Parent=gene-Rv0749;Dbxref=EnsemblGenomes-Gn:Rv0749,EnsemblGenomes-Tr:CCP43494,GOA:P9WF75,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43494.1;Name=CCP43494.1;Note=Rv0749%2C (MTV041.23)%2C len: 142 aa. Possible vapC31%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0748%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv0277c%2C Rv2530c%2Cetc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=vapC31;locus_tag=Rv0749;product=Possible toxin VapC31. Contains PIN domain.;protein_id=CCP43494.1;transl_table=11
AL123456.3	EMBL	gene	841737	841874	.	-	.	ID=gene-Rv0749A;Name=Rv0749A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0749A
AL123456.3	EMBL	CDS	841737	841874	.	-	0	ID=cds-CCP43495.1;Parent=gene-Rv0749A;Dbxref=EnsemblGenomes-Gn:Rv0749A,EnsemblGenomes-Tr:CCP43495,UniProtKB/TrEMBL:I6X9Q1,NCBI_GP:CCP43495.1;Name=CCP43495.1;Note=Rv0749A%2C len: 45 aa. Conserved hypothetical protein (probably gene fragment)%2C similar to part (aa 250-292) of Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa)%2CFASTA scores: opt: 238%2C E(): 1.9e-13%2C (79.07%25 identity in 43 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0749A;product=Hypothetical protein (fragment);protein_id=CCP43495.1;transl_table=11
AL123456.3	EMBL	gene	842033	842278	.	+	.	ID=gene-Rv0750;Name=Rv0750;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0750
AL123456.3	EMBL	CDS	842033	842278	.	+	0	ID=cds-CCP43496.1;Parent=gene-Rv0750;Dbxref=EnsemblGenomes-Gn:Rv0750,EnsemblGenomes-Tr:CCP43496,UniProtKB/TrEMBL:O53813,NCBI_GP:CCP43496.1;Name=CCP43496.1;Note=Rv0750%2C (MTV041.24)%2C len: 81 aa. Conserved hypothetical protein%2C showing almost perfect overlap with C-terminus of Rv0740|MTV041_14 conserved hypothetical protein from Mycobacterium tuberculosis (175 aa)%2C FASTA scores: (93.8%25 identity in 81 aa overlap). Possible duplication. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0750;product=Conserved hypothetical protein;protein_id=CCP43496.1;transl_table=11
AL123456.3	EMBL	gene	842347	843231	.	-	.	ID=gene-Rv0751c;Name=mmsB;gbkey=Gene;gene=mmsB;gene_biotype=protein_coding;locus_tag=Rv0751c
AL123456.3	EMBL	CDS	842347	843231	.	-	0	ID=cds-CCP43497.1;Parent=gene-Rv0751c;Dbxref=EnsemblGenomes-Gn:Rv0751c,EnsemblGenomes-Tr:CCP43497,GOA:P9WNY5,InterPro:IPR002204,InterPro:IPR006115,InterPro:IPR008927,InterPro:IPR011548,InterPro:IPR013328,InterPro:IPR015815,InterPro:IPR016040,InterPro:IPR029154,NCBI_GP:CCP43497.1;Name=CCP43497.1;Note=Rv0751c%2C (MTV041.25c)%2C len: 294 aa. Probable mmsB%2C3-hydroxyisobutyrate dehydrogenase%2C highly similar to others e.g. NP_102847.1|NC_002678 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium loti (294 aa)%3B NP_420167.1|NC_002696 3-hydroxyisobutyrate dehydrogenase from Caulobacter crescentus (298 aa)%3B A32867 3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus (346 aa)%3B etc. Also similar to methylmalonate semialdehyde dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate semialdehyde dehydrogenase from Pseudomonas aeruginosa (298 aa)%2C FASTA scores: opt: 786%2C E(): 0%2C (45.8%25 identity in 297 aa overlap). Also similar to 6-phosphogluconate dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. Contains PS00895 3-hydroxyisobutyrate dehydrogenase signature. Belongs to the 3-hydroxyisobutyrate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmsB;inference=protein motif:PROSITE:PS00895;locus_tag=Rv0751c;product=Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh);protein_id=CCP43497.1;transl_table=11
AL123456.3	EMBL	gene	843242	844414	.	-	.	ID=gene-Rv0752c;Name=fadE9;gbkey=Gene;gene=fadE9;gene_biotype=protein_coding;locus_tag=Rv0752c
AL123456.3	EMBL	CDS	843242	844414	.	-	0	ID=cds-CCP43498.1;Parent=gene-Rv0752c;Dbxref=EnsemblGenomes-Gn:Rv0752c,EnsemblGenomes-Tr:CCP43498,GOA:I6Y4R2,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6Y4R2,NCBI_GP:CCP43498.1;Name=CCP43498.1;Note=Rv0752c%2C (MTV041.26c)%2C len: 390 aa. Probable fadE9%2Cacyl-CoA dehydrogenase%2C highly similar to many e.g. NP_437985.1|NC_003078 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (380 aa)%3B Z99123|BSUB0020_14 from Bacillus subtilis (379 aa)%2C FASTA scores: opt: 853%2C E(): 0%2C (39.8%25 identity in 384 aa overlap)%3B etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1%2C and PS00073 Acyl-Co Adehydrogenases signature 2. Belongs to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE9;inference=protein motif:PROSITE:PS00073;locus_tag=Rv0752c;product=Probable acyl-CoA dehydrogenase FadE9;protein_id=CCP43498.1;transl_table=11
AL123456.3	EMBL	gene	844421	845953	.	-	.	ID=gene-Rv0753c;Name=mmsA;gbkey=Gene;gene=mmsA;gene_biotype=protein_coding;locus_tag=Rv0753c
AL123456.3	EMBL	CDS	844421	845953	.	-	0	ID=cds-CCP43499.1;Parent=gene-Rv0753c;Dbxref=EnsemblGenomes-Gn:Rv0753c,EnsemblGenomes-Tr:CCP43499,GOA:O53816,InterPro:IPR010061,InterPro:IPR015590,InterPro:IPR016160,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,UniProtKB/TrEMBL:O53816,NCBI_GP:CCP43499.1;Name=CCP43499.1;Note=Rv0753c%2C (MTV041.27c)%2C len: 510 aa. Probable mmsA%2Cmethylmalonic acid semialdehyde dehydrogenase%2C highly similar to others e.g. NP_420115.1|NC_002696 putative methylmalonate-semialdehyde dehydrogenase from Caulobacter crescentus (499 aa)%3B L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor (500 aa)%2C FASTA score: (51.6%25 identity in 498 aa overlap)%3B M84911|PSEMMSRAB_2|NP_252260.1|NC_002516 methylmalonate-semialdehyde dehydrogenase from Pseudomonas aeruginosa (497 aa)%2C FASTA scores: opt: 1127%2C E(): 0%2C(47.9%25 identity in 507 aa overlap)%3B etc. Note that also highly similar to malonic semialdehyde oxidative decarboxylases e.g. NP_104968.1|NC_002678 malonic semialdehyde oxidative decarboxylase from Mesorhizobium loti (498 aa)%3B NP_384832.1|NC_003047 putative malonic semialdehyde oxidative decarboxylase protein from Sinorhizobium meliloti (498 aa)%3B etc. Contains PS00070 Aldehyde dehydrogenases cysteine active site. Belongs to the aldehyde dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmsA;inference=protein motif:PROSITE:PS00070;locus_tag=Rv0753c;product=Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH);protein_id=CCP43499.1;transl_table=11
AL123456.3	EMBL	gene	846159	847913	.	+	.	ID=gene-Rv0754;Name=PE_PGRS11;gbkey=Gene;gene=PE_PGRS11;gene_biotype=protein_coding;locus_tag=Rv0754
AL123456.3	EMBL	CDS	846159	847913	.	+	0	ID=cds-CCP43500.1;Parent=gene-Rv0754;Dbxref=EnsemblGenomes-Gn:Rv0754,EnsemblGenomes-Tr:CCP43500,GOA:Q79FW5,InterPro:IPR000084,InterPro:IPR013078,InterPro:IPR029033,UniProtKB/TrEMBL:Q79FW5,NCBI_GP:CCP43500.1;Name=CCP43500.1;Note=Rv0754%2C (MTV041.28)%2C len: 584 aa. PE_PGRS11%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C similar to others e.g. AL0212|MTV008_46 from Mycobacterium tuberculosis (1660 aa)%2C FASTA score: (48.7%25 identity in 345 aa overlap)%3B Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa)%2C FASTA score: (41.6%25 identity in 442 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS11;locus_tag=Rv0754;product=PE-PGRS family protein PE_PGRS11;protein_id=CCP43500.1;transl_table=11
AL123456.3	EMBL	gene	848103	850040	.	-	.	ID=gene-Rv0755c;Name=PPE12;gbkey=Gene;gene=PPE12;gene_biotype=protein_coding;locus_tag=Rv0755c
AL123456.3	EMBL	CDS	848103	850040	.	-	0	ID=cds-CCP43501.1;Parent=gene-Rv0755c;Dbxref=EnsemblGenomes-Gn:Rv0755c,EnsemblGenomes-Tr:CCP43501,GOA:P9WI37,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP43501.1;Name=CCP43501.1;Note=Rv0755c%2C (MTV041.29)%2C len: 645 aa. PPE12%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to others e.g. Z82098|MTCY3C7_23 from Mycobacterium tuberculosis (582 aa)%2C FASTA scores: (56.1%25 identity in 636 aa overlap)%3B Z92774|MTCY6G11_5 from Mycobacterium tuberculosis (552 aa)%2C FASTA scores: (55.8%25 identity in 590 aa overlap)%3B etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE12;locus_tag=Rv0755c;product=PPE family protein PPE12;protein_id=CCP43501.1;transl_table=11
AL123456.3	EMBL	gene	850342	850527	.	-	.	ID=gene-Rv0755A;Name=Rv0755A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0755A
AL123456.3	EMBL	CDS	850342	850527	.	-	0	ID=cds-CCP43502.1;Parent=gene-Rv0755A;Dbxref=EnsemblGenomes-Gn:Rv0755A,EnsemblGenomes-Tr:CCP43502,GOA:Q79FW3,InterPro:IPR009057,InterPro:IPR010921,UniProtKB/TrEMBL:Q79FW3,NCBI_GP:CCP43502.1;Name=CCP43502.1;Note=Rv0755A%2C len: 61 aa. Putative transposase (possibly gene fragment)%2C similar to C-terminal part of Q9EZM2|ISMav2|AF286339_1 putative transposase from Mycobacterium paratuberculosis (395 aa)%2C FASTA scores: opt: 284%2C E(): 5e-13%2C (83.02%25 identity in 53 aa overlap)%3B and to SCJ11.25c|Q9RI80 possible noncomposite transposon transposase from Streptomyces coelicolor (283 aa).;gbkey=CDS;locus_tag=Rv0755A;product=Putative transposase (fragment);protein_id=CCP43502.1;transl_table=11
AL123456.3	EMBL	gene	850642	850713	.	-	.	ID=gene-thrV;Name=thrV;gbkey=Gene;gene=thrV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	850642	850713	.	-	.	ID=rna-thrV;Parent=gene-thrV;Note=codon recognized: ACA%3B thrV%2C tRNA-Thr%2C anticodon tgt%2C length %3D 72;anticodon=(pos:complement(850679..850681));gbkey=tRNA;gene=thrV;product=tRNA-Thr
AL123456.3	EMBL	exon	850642	850713	.	-	.	ID=exon-thrV-1;Parent=rna-thrV;Note=codon recognized: ACA%3B thrV%2C tRNA-Thr%2C anticodon tgt%2C length %3D 72;anticodon=(pos:complement(850679..850681));gbkey=tRNA;gene=thrV;product=tRNA-Thr
AL123456.3	EMBL	gene	850741	851466	.	-	.	ID=gene-Rv0756c;Name=Rv0756c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0756c
AL123456.3	EMBL	CDS	850741	851466	.	-	0	ID=cds-CCP43503.1;Parent=gene-Rv0756c;Dbxref=EnsemblGenomes-Gn:Rv0756c,EnsemblGenomes-Tr:CCP43503,UniProtKB/TrEMBL:P71813,NCBI_GP:CCP43503.1;Name=CCP43503.1;Note=Rv0756c%2C (MTCY369.01c)%2C len: 241 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0756c;product=Unknown protein;protein_id=CCP43503.1;transl_table=11
AL123456.3	EMBL	gene	851608	852351	.	+	.	ID=gene-Rv0757;Name=phoP;gbkey=Gene;gene=phoP;gene_biotype=protein_coding;locus_tag=Rv0757
AL123456.3	EMBL	CDS	851608	852351	.	+	0	ID=cds-CCP43504.1;Parent=gene-Rv0757;Dbxref=EnsemblGenomes-Gn:Rv0757,EnsemblGenomes-Tr:CCP43504,GOA:P71814,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,InterPro:IPR016032,PDB:3R0J,UniProtKB/TrEMBL:P71814,NCBI_GP:CCP43504.1;Name=CCP43504.1;Note=Rv0757%2C (MTCY369.02)%2C len: 247 aa. Possible phoP%2Ctwo component system response phosphate regulon transcriptional regulator (see citations below)%2C highly similar to various transcriptional regulators e.g. CAC32360.1|AL583945 putative two component system response regulator from Streptomyces coelicolor (271 aa)%3B T45446 probable two-component response regulator from Mycobacterium leprae (253 aa)%3B and similar to phoP proteins e.g. P13792|PHOP_BACSU alkaline phosphatase synthesis transcription regulatory protein from Bacillus subtilis (240 aa)%2C FASTA scores: opt: 594%2C E(): 2.3e-33%2C (41.0%25 identity in 234 aa overlap)%3B etc. Also highly similar to Rv3765c from Mycobacterium tuberculosis (234 aa)%2C Rv1033c (257 aa)%2C RV0903c|MTCY31.31c|Q10531 (236 aa)%2C FASTA score: (45.4%25 identity in 229 aa overlap)%3B MTCY10G2_16 and MTU88959_1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=phoP;locus_tag=Rv0757;product=Possible two component system response transcriptional positive regulator PhoP;protein_id=CCP43504.1;transl_table=11
AL123456.3	EMBL	gene	852396	853853	.	+	.	ID=gene-Rv0758;Name=phoR;gbkey=Gene;gene=phoR;gene_biotype=protein_coding;locus_tag=Rv0758
AL123456.3	EMBL	CDS	852396	853853	.	+	0	ID=cds-CCP43505.1;Parent=gene-Rv0758;Dbxref=EnsemblGenomes-Gn:Rv0758,EnsemblGenomes-Tr:CCP43505,GOA:P71815,InterPro:IPR003594,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR009082,UniProtKB/TrEMBL:P71815,NCBI_GP:CCP43505.1;Name=CCP43505.1;Note=Rv0758%2C (MTCY369.03)%2C len: 485 aa. Possible phoR%2Ctwo component system response phosphate sensor kinase membrane-associated%2C highly similar to various sensor kinases e.g. CAC32361.1|AL583945 putative two component system histidine kinase from Streptomyces coelicolor (524 aa)%3B NP_349365.1|NC_003030 Membrane-associated sensory histidine kinase with HAMP domain from Clostridium acetobutylicum (482 aa)%3B and similar to phoP proteins e.g. NP_372216.1|NC_002758 alkaline phosphatase synthesis sensor protein from Staphylococcus aureus (554 aa)%3B P23545|PHOR_BACSU alkaline phosphatase synthesis sensor from Bacillus subtilis (579 aa)%2C FASTA scores: opt: 515%2CE(): 1.9e-25%2C (40.0%25 identity in 230 aa overlap)%3B etc. Also similar to proteins from Mycobacterium tuberculosis e.g. MTCY20G9.16 FASTA scores: (34.5%25 identity in 264 aa overlap)%2C MTU88959_2 (509 aa)%2C MTCY10G2_17%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=phoR;locus_tag=Rv0758;product=Possible two component system response sensor kinase membrane associated PhoR;protein_id=CCP43505.1;transl_table=11
AL123456.3	EMBL	gene	853825	854157	.	-	.	ID=gene-Rv0759c;Name=Rv0759c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0759c
AL123456.3	EMBL	CDS	853825	854157	.	-	0	ID=cds-CCP43506.1;Parent=gene-Rv0759c;Dbxref=EnsemblGenomes-Gn:Rv0759c,EnsemblGenomes-Tr:CCP43506,GOA:P9WML3,InterPro:IPR001310,InterPro:IPR011146,InterPro:IPR019808,NCBI_GP:CCP43506.1;Name=CCP43506.1;Note=Rv0759c%2C (MTCY369.04c)%2C len: 110 aa. Conserved hypothetical protein%2C highly similar (but shorter 45 aa in N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A hypothetical hit-like protein from Mycobacterium leprae (155 aa)%2C FASTA scores: opt: 766%2C E(): 0%2C (78.7%25 identity in 150 aa overlap). Also highly similar (but N-terminus always shorter) to hit-like proteins and protein kinase inhibitors e.g. AAF72728.1|AF265258_1|AF265258 hit-like protein from Rhodococcus sp. (141 aa)%3B NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI) from Borrelia burgdorferi (149 aa) %3B P94252|YHIT_BORBU|BB0379 hypothetical hit-like protein from Borrelia burgdorferi (139 aa)%3B NP_110768.1|NC_002689 hit (histidine triad) family protein from Thermoplasma volcanium (158 aa)%3B P16436|IPK1_BOVIN protein kinase C inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa)%2CFASTA scores: opt: 195%2C E(): 5.2e-08%2C (33.3%25 identity in 111 aa overlap)%3B etc. Also shows similarity with Rv2613c|MTCY01A10.20A conserved hypothetical protein from Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20 hypothetical hit-like protein (144 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0759c;product=Conserved hypothetical protein;protein_id=CCP43506.1;transl_table=11
AL123456.3	EMBL	gene	854267	854686	.	-	.	ID=gene-Rv0760c;Name=Rv0760c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0760c
AL123456.3	EMBL	CDS	854267	854686	.	-	0	ID=cds-CCP43507.1;Parent=gene-Rv0760c;Dbxref=EnsemblGenomes-Gn:Rv0760c,EnsemblGenomes-Tr:CCP43507,GOA:I6WZD7,InterPro:IPR002075,UniProtKB/TrEMBL:I6WZD7,NCBI_GP:CCP43507.1;Name=CCP43507.1;Note=Rv0760c%2C (MTCY369.05)%2C len: 139 aa. Conserved protein%2C similar to N-terminal part of Rv2042c conserved hypothetical protein from Mycobacterium tuberculosis (265 aa)%2C FASTA scores: opt: 150%2C E(): 4.1e-05%2C (28.7%25 identity in 136 aa overlap). Belongs to the NTF2-like (nuclear transport factor 2) protein superfamiily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0760c;product=Conserved protein;protein_id=CCP43507.1;transl_table=11
AL123456.3	EMBL	gene	854699	855826	.	-	.	ID=gene-Rv0761c;Name=adhB;gbkey=Gene;gene=adhB;gene_biotype=protein_coding;locus_tag=Rv0761c
AL123456.3	EMBL	CDS	854699	855826	.	-	0	ID=cds-CCP43508.1;Parent=gene-Rv0761c;Dbxref=EnsemblGenomes-Gn:Rv0761c,EnsemblGenomes-Tr:CCP43508,GOA:P9WQC7,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,InterPro:IPR023921,NCBI_GP:CCP43508.1;Name=CCP43508.1;Note=Rv0761c%2C (MTCY369.06c)%2C len: 375 aa. Possible adhB%2Czinc-containing alcohol dehydrogenase NAD-dependent%2Csimilar to others e.g. AAC15839.1|AF060871_4 hypothetical alcohol dehydrogenase from Rhodococcus rhodochrous (370 aa)%2C FASTA scores: opt: 1234%2C E(): 0%2C (46.8%25 identity in 370 aa overlap)%3B P80468|ADH2_STRCA alcohol dehydrogenase II from Struthio camelus (Ostrich) (379 aa)%3B Q03505|ADH1_RABIT alcohol dehydrogenase alpha chain from Oryctolagus cuniculus (Rabbit) (374 aa)%2C FASTA scores: opt: 872%2C E(): 0%2C (39.1%25 identity in 379 aa overlap)%3B etc. Also similar to adhD alcohol dehydrogenase from Mycobacterium tuberculosis (368 aa). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Belongs to the zinc-containing alcohol dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adhB;inference=protein motif:PROSITE:PS00059;locus_tag=Rv0761c;product=Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB;protein_id=CCP43508.1;transl_table=11
AL123456.3	EMBL	gene	855925	856470	.	-	.	ID=gene-Rv0762c;Name=Rv0762c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0762c
AL123456.3	EMBL	CDS	855925	856470	.	-	0	ID=cds-CCP43509.1;Parent=gene-Rv0762c;Dbxref=EnsemblGenomes-Gn:Rv0762c,EnsemblGenomes-Tr:CCP43509,UniProtKB/TrEMBL:I6XW93,NCBI_GP:CCP43509.1;Name=CCP43509.1;Note=Rv0762c%2C (MTCY369.07c)%2C len: 181 aa. Conserved hypothetical protein%2C showing weak similarity to D90907_77|P73575 hypothetical 31.3KD protein from Synechocystis sp%2C FASTA scores: E(): 0.0012%2C (30.4%25 identity in 92 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0762c;product=Conserved hypothetical protein;protein_id=CCP43509.1;transl_table=11
AL123456.3	EMBL	gene	856473	856679	.	-	.	ID=gene-Rv0763c;Name=Rv0763c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0763c
AL123456.3	EMBL	CDS	856473	856679	.	-	0	ID=cds-CCP43510.1;Parent=gene-Rv0763c;Dbxref=EnsemblGenomes-Gn:Rv0763c,EnsemblGenomes-Tr:CCP43510,UniProtKB/TrEMBL:P71820,NCBI_GP:CCP43510.1;Name=CCP43510.1;Note=Rv0763c%2C (MTCY369.08c)%2C len: 68 aa. Possible ferredoxin%2C similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa)%3B AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa)%3B AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa)%3B etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c probable cytochrome P450 51 from Mycobacterium tuberculosis (451 aa)%2C FASTA scores: opt: 137%2C E(): 0.00013%2C (36.4%25 identity in 66 aa overlap). Also similar to putative ferredoxins Rv3503c and Rv1786 from Mycobacterium tuberculosis. Could belong to the bacterial type ferredoxin family.;gbkey=CDS;locus_tag=Rv0763c;product=Possible ferredoxin;protein_id=CCP43510.1;transl_table=11
AL123456.3	EMBL	gene	856682	858037	.	-	.	ID=gene-Rv0764c;Name=cyp51;gbkey=Gene;gene=cyp51;gene_biotype=protein_coding;locus_tag=Rv0764c
AL123456.3	EMBL	CDS	856682	858037	.	-	0	ID=cds-CCP43511.1;Parent=gene-Rv0764c;Dbxref=EnsemblGenomes-Gn:Rv0764c,EnsemblGenomes-Tr:CCP43511,GOA:P9WPP9,InterPro:IPR001128,InterPro:IPR002403,InterPro:IPR017972,PDB:1E9X,PDB:1EA1,PDB:1H5Z,PDB:1U13,PDB:1X8V,PDB:2BZ9,PDB:2CI0,PDB:2CIB,PDB:2VKU,PDB:2W09,PDB:2W0A,PDB:2W0B,NCBI_GP:CCP43511.1;Name=CCP43511.1;Note=Rv0764c%2C (MT0788%2C MTCY369.09c)%2C len: 451 aa. Cyp51%2Ccytochrome P450 51 (sterol 14-alpha demethylase)%2C similar to others e.g. Q16850|CP51_HUMAN cytochrome P450 51 (CYPL1) (P450L1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) from Homo sapiens (509 aa)%2C FASTA scores: opt: 848%2C E(): 0%2C (33.9%25 identity in 439 aa overlap)%3B NP_172633.1|NC_003070 putative obtusifoliol 14-alpha demethylase from Arabidopsis thaliana (488 aa)%3B P93596|CP51_WHEAT cytochrome P450 51 (CYPL1) (P450-L1A1) (obtusifoliol 14-alpha demethylase) from Triticum aestivum (453 aa)%3B etc. Also similar to many other Mycobacterium tuberculosis cytochromes P450 e.g. Rv1394c%2C FASTA score: (22.5%25 identity in 444 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp51;inference=protein motif:PROSITE:PS00086;locus_tag=Rv0764c;product=Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM);protein_id=CCP43511.1;transl_table=11
AL123456.3	EMBL	gene	858037	858864	.	-	.	ID=gene-Rv0765c;Name=Rv0765c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0765c
AL123456.3	EMBL	CDS	858037	858864	.	-	0	ID=cds-CCP43512.1;Parent=gene-Rv0765c;Dbxref=EnsemblGenomes-Gn:Rv0765c,EnsemblGenomes-Tr:CCP43512,GOA:I6WZD9,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:I6WZD9,NCBI_GP:CCP43512.1;Name=CCP43512.1;Note=Rv0765c%2C (MTCY369.10c)%2C len: 275 aa. Probable oxidoreductase%2C similar others e.g. P39071|DHBA_BACSU 2%2C3-dihydro-2%2C3-dihydroxybenzoate dehydrogenase from Bacillus subtilis (261 aa)%2C FASTA scores: opt: 385%2C E(): 1.8e-17%2C (30.6%25 identity in 252 aa overlap)%3B AAF81239.1|AF263012 putative beta-ketoacyl reductase from Streptomyces griseus (274 aa)%3B NP_436514.1|NC_003037 putative oxidoreductase from Sinorhizobium meliloti (240 aa)%3B etc. Also similar to several other oxidoreductases from Mycobacterium tuberculosis e.g. Rv1544|MTCY48.21%2CFASTA score: (32.6%25 identity in 267 aa overlap)%3B etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature.;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0765c;product=Probable oxidoreductase;protein_id=CCP43512.1;transl_table=11
AL123456.3	EMBL	gene	858864	860072	.	-	.	ID=gene-Rv0766c;Name=cyp123;gbkey=Gene;gene=cyp123;gene_biotype=protein_coding;locus_tag=Rv0766c
AL123456.3	EMBL	CDS	858864	860072	.	-	0	ID=cds-CCP43513.1;Parent=gene-Rv0766c;Dbxref=EnsemblGenomes-Gn:Rv0766c,EnsemblGenomes-Tr:CCP43513,GOA:P9WPP5,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,NCBI_GP:CCP43513.1;Name=CCP43513.1;Note=Rv0766c%2C (MT0790%2C MTCY369.11c)%2C len: 402 aa. Probable cyp123%2C cytochrome P-450%2C similar to others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 from Saccharopolyspora erythraea (405 aa)%2C FASTA scores: opt: 770%2C E(): 0%2C (36.9%25 identity in 406 aa overlap)%3B T36526 probable cytochrome P450 hydroxylase from Streptomyces coelicolor (411 aa)%3B P27632|CPXM_BACSU cytochrome P450 109 from Bacillus subtilis (405 aa)%3B etc. Also similar to several other cytochromes P-450 from Mycobacterium tuberculosis e.g. Rv1256c|MTCY50.26 (405 aa)%2C FASTA score: (35.2%25 identity in 389 aa overlap)%3B etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp123;inference=protein motif:PROSITE:PS00086;locus_tag=Rv0766c;product=Probable cytochrome P450 123 Cyp123;protein_id=CCP43513.1;transl_table=11
AL123456.3	EMBL	gene	860069	860710	.	-	.	ID=gene-Rv0767c;Name=Rv0767c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0767c
AL123456.3	EMBL	CDS	860069	860710	.	-	0	ID=cds-CCP43514.1;Parent=gene-Rv0767c;Dbxref=EnsemblGenomes-Gn:Rv0767c,EnsemblGenomes-Tr:CCP43514,GOA:P9WMD7,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,InterPro:IPR023772,NCBI_GP:CCP43514.1;Name=CCP43514.1;Note=Rv0767c%2C (MTCY369.12c)%2C len: 213 aa. Conserved hypothetical protein%2C showing weak similarity with AL133220|SCC75A_26 hypothetical protein from Streptomyces coelicolor (215 aa)%2C FASTA scores: opt: 152%2C E(): 0.0048%2C(28.4%25 identity in 204 aa overlap).;gbkey=CDS;locus_tag=Rv0767c;product=Conserved hypothetical protein;protein_id=CCP43514.1;transl_table=11
AL123456.3	EMBL	gene	860912	862381	.	+	.	ID=gene-Rv0768;Name=aldA;gbkey=Gene;gene=aldA;gene_biotype=protein_coding;locus_tag=Rv0768
AL123456.3	EMBL	CDS	860912	862381	.	+	0	ID=cds-CCP43515.1;Parent=gene-Rv0768;Dbxref=EnsemblGenomes-Gn:Rv0768,EnsemblGenomes-Tr:CCP43515,GOA:I6X9R9,InterPro:IPR015590,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR026460,InterPro:IPR029510,UniProtKB/TrEMBL:I6X9R9,NCBI_GP:CCP43515.1;Name=CCP43515.1;Note=Rv0768%2C (MTCY369.13)%2C len: 489 aa. Probable aldA%2CNAD-dependent aldehyde dehydrogenase%2C highly similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid dehydrogenase from Rhodococcus ruber (474 aa)%3B NP_285450.1|NC_001264 aldehyde dehydrogenase from Deinococcus radiodurans (495 aa)%3B NP_241405.1|NC_002570 NADP-dependent aldehyde dehydrogenase from Bacillus halodurans (498 aa)%3B P42757|DHAB_ATRHO betaine-aldehyde dehydrogenase precursor from Atriplex hortensis (Mountain spinach) (502 aa)%2C FASTA scores: opt: 1001%2C E(): 0%2C (35.6%25 identity in 486 aa overlap)%3B etc. Also highly similar to Rv0223c aldehyde dehydrogenase from Mycobacterium tuberculosis (487 aa). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Belongs to the aldehyde dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aldA;inference=protein motif:PROSITE:PS00687;locus_tag=Rv0768;product=Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]);protein_id=CCP43515.1;transl_table=11
AL123456.3	EMBL	gene	862412	863158	.	+	.	ID=gene-Rv0769;Name=Rv0769;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0769
AL123456.3	EMBL	CDS	862412	863158	.	+	0	ID=cds-CCP43516.1;Parent=gene-Rv0769;Dbxref=EnsemblGenomes-Gn:Rv0769,EnsemblGenomes-Tr:CCP43516,GOA:P9WGQ9,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,NCBI_GP:CCP43516.1;Name=CCP43516.1;Note=Rv0769%2C (MTCY369.14)%2C len: 248 aa. Probable dehydrogenase/reductase%2C similar to others%2C especially short-chain type dehydrogenases/reductases and 3-oxoacyl-(acyl-carrier protein) reductases e.g. NP_106890.1|NC_002678 probable short-chain type dehydrogenase/reductase from Mesorhizobium loti (374 aa)%3B NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein) reductase from Bacillus halodurans (246 aa)%3B P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier protein] reductase from Cuphea lanceolata (320 aa)%3B P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa)%2C FASTA scores: opt: 536%2C E(): 6.5e-27%2C (37.7%25 identity in 247 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. MTCY02B10.14%2C FASTA score: (33.7%25 identity in 249 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0769;product=Probable dehydrogenase/reductase;protein_id=CCP43516.1;transl_table=11
AL123456.3	EMBL	repeat_region	863155	863255	.	+	.	ID=id-AL123456.3:863155..863255;Note=101 bp Mycobacterial Interspersed Repetitive Unit%2CClass I;gbkey=repeat_region
AL123456.3	EMBL	gene	863256	864143	.	+	.	ID=gene-Rv0770;Name=Rv0770;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0770
AL123456.3	EMBL	CDS	863256	864143	.	+	0	ID=cds-CCP43517.1;Parent=gene-Rv0770;Dbxref=EnsemblGenomes-Gn:Rv0770,EnsemblGenomes-Tr:CCP43517,GOA:P9WNY3,InterPro:IPR002204,InterPro:IPR006115,InterPro:IPR008927,InterPro:IPR013328,InterPro:IPR015815,InterPro:IPR016040,InterPro:IPR029154,NCBI_GP:CCP43517.1;Name=CCP43517.1;Note=Rv0770%2C (MTCY369.15)%2C len: 295 aa. Probable dehydrogenase/reductase%2C 3-hydroxyisobutyrate dehydrogenase family%2C possibly 3-hydroxyisobutyrate dehydrogenase or 2-hydroxy-3-oxopropionate reductase%2C similar to others e.g. P23523|GARR_ECOLI 2-hydroxy-3-oxopropionate reductase (tartronate semialdehyde reductase) (TSAR) from Escherichia coli strain K12 (294 aa)%2C FASTA scores: opt: 469%2C E(): 6.7e-22%2C (34.4%25 identity in 282 aa overlap)%3B P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase (hibadh) from Pseudomonas aeruginosa (298 aa)%2C FASTA scores: opt: 439%2C E(): 4.3e-20%2C (34.9%25 identity in 269 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1122 and Rv1844c. Seems to belong to the 3-hydroxyisobutyrate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0770;product=Probable dehydrogenase/reductase;protein_id=CCP43517.1;transl_table=11
AL123456.3	EMBL	gene	864140	864574	.	+	.	ID=gene-Rv0771;Name=Rv0771;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0771
AL123456.3	EMBL	CDS	864140	864574	.	+	0	ID=cds-CCP43518.1;Parent=gene-Rv0771;Dbxref=EnsemblGenomes-Gn:Rv0771,EnsemblGenomes-Tr:CCP43518,GOA:I6Y4S7,InterPro:IPR003779,InterPro:IPR029032,UniProtKB/TrEMBL:I6Y4S7,NCBI_GP:CCP43518.1;Name=CCP43518.1;Note=Rv0771%2C (MTCY369.16)%2C len: 144 aa. Possible 4-carboxymuconolactone decarboxylase%2C showing similarity with other carboxymuconolactone decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein from Pseudomonas putida (130 aa)%3B P20370|DC4C_ACICA 4-carboxymuconolactone decarboxylase (CMD) from Acinetobacter sp. ADP1 (134 aa)%2CFASTA scores: opt: 174%2C E(): 0.00075%2C (31.4%25 identity in 121 aa overlap)%3B C-terminus of NP_421214.1|NC_002696 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Caulobacter crescentus (393 aa)%3B C-terminus of T47115 probable 4-carboxymuconolactone decarboxylase / 3-oxoadipate enol-lactone hydrolase from Streptomyces sp (373 aa)%3B NP_407104.1|NC_003143 putative gamma carboxymuconolactone decarboxylase from Yersinia pestis (131 aa)%3B etc.;gbkey=CDS;locus_tag=Rv0771;product=Possible 4-carboxymuconolactone decarboxylase (CMD);protein_id=CCP43518.1;transl_table=11
AL123456.3	EMBL	gene	864586	865854	.	+	.	ID=gene-Rv0772;Name=purD;gbkey=Gene;gene=purD;gene_biotype=protein_coding;locus_tag=Rv0772
AL123456.3	EMBL	CDS	864586	865854	.	+	0	ID=cds-CCP43519.1;Parent=gene-Rv0772;Dbxref=EnsemblGenomes-Gn:Rv0772,EnsemblGenomes-Tr:CCP43519,GOA:P9WHM9,InterPro:IPR000115,InterPro:IPR011054,InterPro:IPR011761,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,InterPro:IPR020559,InterPro:IPR020560,InterPro:IPR020561,InterPro:IPR020562,NCBI_GP:CCP43519.1;Name=CCP43519.1;Note=Rv0772%2C (MTCY369.17)%2C len: 422 aa. Probable purD%2Cphosphoribosylamine--glycine ligase%2C equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08 phosphoribosylamine--glycine ligase from Mycobacterium leprae (422 aa)%2C FASTA scores: opt: 2272%2C E(): 0%2C (81.8%25 identity in 422 aa overlap). Also highly similar to others e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine ligase from Streptomyces coelicolor (416 aa)%3B P1564|PUR2_ECOLI phosphoribosylamine--glycine ligase from Escherichia coli (429 aa)%2C FASTA scores: opt: 1039%2C E(): 0%2C (42.7%25 identity in 431 aa overlap)%3B etc. Belongs to the GarS family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purD;locus_tag=Rv0772;product=Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) (5'-phosphoribosylglycinamide synthetase);protein_id=CCP43519.1;transl_table=11
AL123456.3	EMBL	gene	865851	867389	.	-	.	ID=gene-Rv0773c;Name=ggtA;gbkey=Gene;gene=ggtA;gene_biotype=protein_coding;locus_tag=Rv0773c
AL123456.3	EMBL	CDS	865851	867389	.	-	0	ID=cds-CCP43520.1;Parent=gene-Rv0773c;Dbxref=EnsemblGenomes-Gn:Rv0773c,EnsemblGenomes-Tr:CCP43520,GOA:I6X9S5,InterPro:IPR000101,InterPro:IPR029055,UniProtKB/TrEMBL:I6X9S5,NCBI_GP:CCP43520.1;Name=CCP43520.1;Note=Rv0773c%2C (MTCY369.18)%2C len: 512 aa. Probable ggtA%2Cbifunctional acylase including cephalosporin acylase%2C and gamma-glutamyl transpeptidase%3B highly similar to others e.g. NP_295247.1|NC_001263 cephalosporin acylase from Deinococcus radiodurans (535 aa)%3B NP_248854.1|NC_002516 probable gamma-glutamyltranspeptidase from Pseudomonas aeruginosa (538 aa)%3B P15557|PAC1_PSES3 acylase ACY 1 [includes: cephalosporin acylase (GL-7ACA acylase)%3B gamma-glutamyltranspeptidase (GGT)] from Pseudomonas sp. strain SE83 (558 aa)%2C FASTA scores: opt: 784%2C E(): 0%2C(34.2%25 identity in 526 aa overlap)%3B NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein similar to gamma-glutamyltransferase from Bacillus subtilis (525 aa)%2C FASTA scores: opt: 1169%2C E(): 0%2C (40.1%25 identity in 516 aa overlap)%3B etc. Also similar to Rv2394|ggtB from Mycobacterium tuberculosis. Member of GL-7ACA acylases and to GGT group.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ggtA;locus_tag=Rv0773c;product=Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT);protein_id=CCP43520.1;transl_table=11
AL123456.3	EMBL	gene	867440	868351	.	-	.	ID=gene-Rv0774c;Name=Rv0774c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0774c
AL123456.3	EMBL	CDS	867440	868351	.	-	0	ID=cds-CCP43521.1;Parent=gene-Rv0774c;Dbxref=EnsemblGenomes-Gn:Rv0774c,EnsemblGenomes-Tr:CCP43521,InterPro:IPR000801,InterPro:IPR006311,InterPro:IPR029058,UniProtKB/TrEMBL:I6Y8R4,NCBI_GP:CCP43521.1;Name=CCP43521.1;Note=Rv0774c%2C (MTCY369.19c)%2C len: 303 aa. Possible conserved exported protein with hydrophobic region near N-terminus%2C highly similar%2C except in N-terminus%2C to Rv0519c|Z97831|MTY20G10.09c|O33364 hypothetical protein from Mycobacterium tuberculosis (300 aa)%2C FASTA scores: opt: 1092%2C E(): 0%2C (57.9%25 identity in 299 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature%2C and PS00120 Lipases%2C serine active site. So could be a lipase. Start changed since first submission (-9 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv0774c;product=Probable conserved exported protein;protein_id=CCP43521.1;transl_table=11
AL123456.3	EMBL	gene	868407	869030	.	+	.	ID=gene-Rv0775;Name=Rv0775;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0775
AL123456.3	EMBL	CDS	868407	869030	.	+	0	ID=cds-CCP43522.1;Parent=gene-Rv0775;Dbxref=EnsemblGenomes-Gn:Rv0775,EnsemblGenomes-Tr:CCP43522,GOA:P71830,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:P71830,NCBI_GP:CCP43522.1;Name=CCP43522.1;Note=Rv0775%2C (MTCY369.20)%2C len: 207 aa. Conserved hypothetical protein%2C showing some similarity to other proteins e.g. ECAE000186_11|MG1655 hypothetical protein from Escherichia coli strain K-12 (178 aa)%2C FASTA scores: E(): 6.4e-05%2C (27.2%25 identity in 147 aa overlap)%3B P41037|BIH_ECOLI hypothetical transcriptional regulator from Escherichia coli (103 aa)%2C FASTA scores: opt: 138%2CE(): 0.003%2C (30.9%25 identity in 97 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0775;product=Conserved hypothetical protein;protein_id=CCP43522.1;transl_table=11
AL123456.3	EMBL	gene	868984	869763	.	-	.	ID=gene-Rv0776c;Name=Rv0776c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0776c
AL123456.3	EMBL	CDS	868984	869763	.	-	0	ID=cds-CCP43523.1;Parent=gene-Rv0776c;Dbxref=EnsemblGenomes-Gn:Rv0776c,EnsemblGenomes-Tr:CCP43523,InterPro:IPR007362,InterPro:IPR008306,UniProtKB/TrEMBL:I6Y4S9,NCBI_GP:CCP43523.1;Name=CCP43523.1;Note=Rv0776c%2C (MTCY369.21a)%2C len: 259 aa. Conserved hypothetical protein%2C similar (except first 50 aa) to P72737|D90900_57 hypothetical protein from Synechocystis sp. strain PCC 6803 (261 aa)%2C FASTA scores: opt: 337%2C E(): 1.7e-15%2C (30.5%25 identity in 266 aa overlap).;gbkey=CDS;locus_tag=Rv0776c;product=Conserved hypothetical protein;protein_id=CCP43523.1;transl_table=11
AL123456.3	EMBL	gene	870008	871426	.	+	.	ID=gene-Rv0777;Name=purB;gbkey=Gene;gene=purB;gene_biotype=protein_coding;locus_tag=Rv0777
AL123456.3	EMBL	CDS	870008	871426	.	+	0	ID=cds-CCP43524.1;Parent=gene-Rv0777;Dbxref=EnsemblGenomes-Gn:Rv0777,EnsemblGenomes-Tr:CCP43524,GOA:I6XWA1,InterPro:IPR000362,InterPro:IPR004769,InterPro:IPR008948,InterPro:IPR019468,InterPro:IPR020557,InterPro:IPR022761,InterPro:IPR024083,UniProtKB/TrEMBL:I6XWA1,NCBI_GP:CCP43524.1;Name=CCP43524.1;Note=Rv0777%2C (MTCY369.21b)%2C len: 472 aa. Probable purB%2Cadenylosuccinate lyase%2C equivalent (but shorter 15 aa) to MLCB5.13|Z95151|g2076607|PURB adenylosuccinate lyase from Mycobacterium leprae (487 aa)%2C FASTA scores: opt: 2640%2CE(): 0%2C (86.7%25 identity in 472 aa overlap). More similar to eukaryotic adenylosuccinate lyases than to prokaryotic adenylosuccinate lyases e.g. P54822|PUR8_MOUSE adenylosuccinate lyase from Mus musculus (484 aa)%2C FASTA scores: opt: 762%2C E(): 0%2C (32.4%25 identity in 445 aa overlap)%3B CAB99134.1|AL390188 putative adenylosuccino lyase (fragment) from Streptomyces coelicolor (362 aa)%3B etc. Contains PS00163 Fumarate lyases signature. Belongs to the lyase 1 family%2C adenylossucinate lyase subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purB;inference=protein motif:PROSITE:PS00163;locus_tag=Rv0777;product=Probable adenylosuccinate lyase PurB (adenylosuccinase) (ASL) (ASASE);protein_id=CCP43524.1;transl_table=11
AL123456.3	EMBL	gene	871431	872675	.	+	.	ID=gene-Rv0778;Name=cyp126;gbkey=Gene;gene=cyp126;gene_biotype=protein_coding;locus_tag=Rv0778
AL123456.3	EMBL	CDS	871431	872675	.	+	0	ID=cds-CCP43525.1;Parent=gene-Rv0778;Dbxref=EnsemblGenomes-Gn:Rv0778,EnsemblGenomes-Tr:CCP43525,GOA:P9WPN9,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,NCBI_GP:CCP43525.1;Name=CCP43525.1;Note=Rv0778%2C (MT0802%2C MTCY369.22)%2C len: 414 aa. Possible cyp126%2C cytochrome P-450%2C similar to other cytochromes and related proteins e.g. AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from Streptomyces rishiriensis (407 aa)%3B Q59723|PSECYTOCHR_1 cytochrome p-450 linalool 8-monooxygenase (lin C) from Pseudomonas incognita (406 aa)%2C FASTA scores: opt: 769%2C E(): 0%2C (37.0%25 identity in 411 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c%2C Rv2266%2C Rv3545c%2C etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp126;inference=protein motif:PROSITE:PS00086;locus_tag=Rv0778;product=Possible cytochrome P450 126 Cyp126;protein_id=CCP43525.1;transl_table=11
AL123456.3	EMBL	gene	872672	873292	.	-	.	ID=gene-Rv0779c;Name=Rv0779c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0779c
AL123456.3	EMBL	CDS	872672	873292	.	-	0	ID=cds-CCP43526.1;Parent=gene-Rv0779c;Dbxref=EnsemblGenomes-Gn:Rv0779c,EnsemblGenomes-Tr:CCP43526,GOA:P71833,UniProtKB/TrEMBL:P71833,NCBI_GP:CCP43526.1;Name=CCP43526.1;Note=Rv0779c%2C (MTCY369.23c)%2C len: 206 aa. Possible conserved transmembrane protein%2C equivalent to Z95151|MLCB5_14 O05747 conserved hypothetical protein from Mycobacterium leprae (206 aa)%2C FASTA scores: opt: 902%2C E(): 0%2C (67.2%25 identity in 204 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv0779c;product=Possible conserved transmembrane protein;protein_id=CCP43526.1;transl_table=11
AL123456.3	EMBL	gene	873343	874236	.	+	.	ID=gene-Rv0780;Name=purC;gbkey=Gene;gene=purC;gene_biotype=protein_coding;locus_tag=Rv0780
AL123456.3	EMBL	CDS	873343	874236	.	+	0	ID=cds-CCP43527.1;Parent=gene-Rv0780;Dbxref=EnsemblGenomes-Gn:Rv0780,EnsemblGenomes-Tr:CCP43527,GOA:P9WHN1,InterPro:IPR001636,InterPro:IPR013816,InterPro:IPR018236,InterPro:IPR028923,NCBI_GP:CCP43527.1;Name=CCP43527.1;Note=Rv0780%2C (MTCY369.24)%2C len: 297 aa. PurC%2Cphosphoribosylaminoimidazole- succinocarboxamide synthase (see citations below)%2C equivalent to MTU34957_1|PURC phosphoribosylaminoimidazole-succinocarboxamide synthase from Mycobacterium leprae (297 aa)%2C FASTA scores: opt: 1986%2C E(): 0%2C (99.3%25 identity in 297 aa overlap). Also similar to others e.g. CAB56351.1|AL118514 phosphoribosylaminoimidazole-succinocarboxamide synthase from Streptomyces coelicolor (299 aa)%3B etc. Contains PS01058 SAICAR synthetase signature 2. Belongs to the SAICAR synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purC;inference=protein motif:PROSITE:PS01058;locus_tag=Rv0780;product=Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC (SAICAR synthetase);protein_id=CCP43527.1;transl_table=11
AL123456.3	EMBL	gene	874233	874943	.	+	.	ID=gene-Rv0781;Name=ptrBa;gbkey=Gene;gene=ptrBa;gene_biotype=protein_coding;gene_synonym=ptrBb;locus_tag=Rv0781
AL123456.3	EMBL	CDS	874233	874943	.	+	0	ID=cds-CCP43528.1;Parent=gene-Rv0781;Dbxref=EnsemblGenomes-Gn:Rv0781,EnsemblGenomes-Tr:CCP43528,GOA:P71835,InterPro:IPR002470,InterPro:IPR023302,UniProtKB/TrEMBL:P71835,NCBI_GP:CCP43528.1;Name=CCP43528.1;Note=Rv0781%2C (MTCY369.25)%2C len: 236 aa. Probable ptrBa%2Cfirst part of protease II%2C equivalent to N-terminus of NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa)%2C FASTA scores: opt: 204%2C E(): 7.4e-07%2C (29.6%25 identity in 230 aa overlap)%3B etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II%2C but we can find no error in the cosmid sequence to account for this. Belongs to peptidase family S9A%3B also known as the prolyl oligopeptidase family. Note that previously known as ptrBb. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;gbkey=CDS;gene=ptrBa;locus_tag=Rv0781;product=Probable protease II PtrBa [first part] (oligopeptidase B);protein_id=CCP43528.1;transl_table=11
AL123456.3	EMBL	gene	874732	876390	.	+	.	ID=gene-Rv0782;Name=ptrBb;gbkey=Gene;gene=ptrBb;gene_biotype=protein_coding;gene_synonym=ptrBa;locus_tag=Rv0782
AL123456.3	EMBL	CDS	874732	876390	.	+	0	ID=cds-CCP43529.1;Parent=gene-Rv0782;Dbxref=EnsemblGenomes-Gn:Rv0782,EnsemblGenomes-Tr:CCP43529,GOA:P71834,InterPro:IPR001375,InterPro:IPR002470,InterPro:IPR023302,InterPro:IPR029058,UniProtKB/TrEMBL:P71834,NCBI_GP:CCP43529.1;Name=CCP43529.1;Note=Rv0782%2C (MTCY369.26)%2C len: 552 aa. Probable ptrBb%2Csecond part of protease II%2C equivalent to C-terminus of NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa)%2C FASTA scores: opt: 1251%2C E(): 0%2C (42.7%25 identity in 489 aa overlap)%3B etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II%2C but we can find no error in the cosmid sequence to account for this. Belongs to peptidase family S9A%3B also known as the prolyl oligopeptidase family. Note that previously known as ptrBa. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;gbkey=CDS;gene=ptrBb;locus_tag=Rv0782;product=Probable protease II PtrBb [second part] (oligopeptidase B);protein_id=CCP43529.1;transl_table=11
AL123456.3	EMBL	gene	876818	878440	.	-	.	ID=gene-Rv0783c;Name=emrB;gbkey=Gene;gene=emrB;gene_biotype=protein_coding;locus_tag=Rv0783c
AL123456.3	EMBL	CDS	876818	878440	.	-	0	ID=cds-CCP43530.1;Parent=gene-Rv0783c;Dbxref=EnsemblGenomes-Gn:Rv0783c,EnsemblGenomes-Tr:CCP43530,GOA:P9WG89,InterPro:IPR004638,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP43530.1;Name=CCP43530.1;Note=Rv0783c%2C (MTCY369.27c)%2C len: 540 aa. Possible emrB%2Cintegral membrane drug efflux protein%2C member of major facilitator superfamily (MFS)%2C equivalent to AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from Mycobacterium avium (538 aa). Also similar to other membrane proteins e.g. CAB61606.1|AL133210 putative export protein from Streptomyces coelicolor (496 aa)%3B NP_108371.1|NC_002678 efflux pump protein FarB from Mesorhizobium loti (511 aa)%3B P44927|EMRB_HAEINHI0897| multidrug resistance protein b homologue from Haemophilus influenzae (510 aa)%2C FASTA scores: opt: 706%2C E(): 1.3e-36%2C(30.4%25 identity in 408 aa overlap)%3B etc. Also similar to Rv2333c|MTCY3G12.01 from Mycobacterium tuberculosis (537 aa)%2C FASTA score: (28.2%25 identity in 408 aa overlap)%3B and Rv1410c|MTCY21B4.27c from Mycobacterium tuberculosis (518 aa)%2C FASTA score: (26.8%25 identity in 496 aa overlap). Belongs to the major facilitator family%3B also known as the drug resistance translocase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=emrB;locus_tag=Rv0783c;product=Possible multidrug resistance integral membrane efflux protein EmrB;protein_id=CCP43530.1;transl_table=11
AL123456.3	EMBL	gene	878638	879324	.	+	.	ID=gene-Rv0784;Name=Rv0784;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0784
AL123456.3	EMBL	CDS	878638	879324	.	+	0	ID=cds-CCP43531.1;Parent=gene-Rv0784;Dbxref=EnsemblGenomes-Gn:Rv0784,EnsemblGenomes-Tr:CCP43531,GOA:P71837,InterPro:IPR011330,UniProtKB/TrEMBL:P71837,NCBI_GP:CCP43531.1;Name=CCP43531.1;Note=Rv0784%2C (MTC369.28)%2C len: 228 aa. Conserved hypothetical protein%2C with some similarity to MLCB5_20|O05752 hypothetical protein from Mycobacterium leprae (193 aa)%2C FASTA scores: opt: 141%2C E(): 0.0022%2C(36.0%25 identity in 114 aa overlap). Also similar to N-terminus of NP_253002.1|NC_002516 conserved hypothetical protein from Pseudomonas aeruginosa (253 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0784;product=Conserved hypothetical protein;protein_id=CCP43531.1;transl_table=11
AL123456.3	EMBL	gene	879340	881040	.	+	.	ID=gene-Rv0785;Name=Rv0785;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0785
AL123456.3	EMBL	CDS	879340	881040	.	+	0	ID=cds-CCP43532.1;Parent=gene-Rv0785;Dbxref=EnsemblGenomes-Gn:Rv0785,EnsemblGenomes-Tr:CCP43532,GOA:P71838,InterPro:IPR003953,InterPro:IPR014614,NCBI_GP:CCP43532.1;Name=CCP43532.1;Note=Rv0785%2C (MTCY369.29)%2C len: 566 aa. Conserved protein%2C highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa)%3B SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa)%3B AE001863|AE001863_31 from Deinococcus radiodurans (554 aa)%2C FASTA scores: opt: 2243%2C E(): 0%2C (61.1%25 identity in 550 aa overlap)%3B YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa)%2CFASTA scores: opt: 169%2C E(): 0.0014%2C (23.8%25 identity in 542 aa overlap)%3B etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa)%2C FASTA score: (26.7%25 identity in 587 aa overlap). And shows similarity with other dehydrogenases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0785;product=Conserved protein;protein_id=CCP43532.1;transl_table=11
AL123456.3	EMBL	gene	881075	881464	.	-	.	ID=gene-Rv0786c;Name=Rv0786c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0786c
AL123456.3	EMBL	CDS	881075	881464	.	-	0	ID=cds-CCP43533.1;Parent=gene-Rv0786c;Dbxref=EnsemblGenomes-Gn:Rv0786c,EnsemblGenomes-Tr:CCP43533,InterPro:IPR001279,UniProtKB/TrEMBL:P71839,NCBI_GP:CCP43533.1;Name=CCP43533.1;Note=Rv0786c%2C (MTCY369.30c)%2C len: 129 aa. Conserved protein%2C similar to three other hypothetical proteins from Streptomyces coelicolor e.g. SC7H1.08c|T35703 hypothetical protein (202 aa)%2C FASTA scores: opt: 241%2C E(): 5.1e-10%2C(41.0%25 identity in 105 aa overlap)%3B SC3A7.08|T29426 (211 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0786c;product=Conserved protein;protein_id=CCP43533.1;transl_table=11
AL123456.3	EMBL	gene	881459	882418	.	+	.	ID=gene-Rv0787;Name=Rv0787;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0787
AL123456.3	EMBL	CDS	881459	882418	.	+	0	ID=cds-CCP43534.1;Parent=gene-Rv0787;Dbxref=EnsemblGenomes-Gn:Rv0787,EnsemblGenomes-Tr:CCP43534,GOA:P71840,UniProtKB/TrEMBL:P71840,NCBI_GP:CCP43534.1;Name=CCP43534.1;Note=Rv0787%2C (MTCY369.31)%2C len: 319 aa. Unknown protein%2Cequivalent to AAK45053.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 77 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0787;product=Unknown protein;protein_id=CCP43534.1;transl_table=11
AL123456.3	EMBL	gene	882524	882763	.	+	.	ID=gene-Rv0787A;Name=Rv0787A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0787A
AL123456.3	EMBL	CDS	882524	882763	.	+	0	ID=cds-CCP43535.1;Parent=gene-Rv0787A;Dbxref=EnsemblGenomes-Gn:Rv0787A,EnsemblGenomes-Tr:CCP43535,InterPro:IPR003850,UniProtKB/TrEMBL:I6Y8S6,NCBI_GP:CCP43535.1;Name=CCP43535.1;Note=Rv0787A%2C len: 79 aa. Conserved protein%2C equivalent to MLCB5.24 hypothetical protein from Mycobacterium leprae (79 aa)%2C FASTA scores: opt: 434%2C (84.8%25 identity in 79 aa overlap). Also similar to P12049|YEXA_BACSU hypothetical 9.7 kDa protein from Bacillus subtilis (84 aa)%2C FASTA scores: opt: 172%2C E(): 4e-06%2C (44.4%25 identity in 72 aa overlap). Belongs to the UPF0062 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0787A;product=Conserved protein;protein_id=CCP43535.1;transl_table=11
AL123456.3	EMBL	gene	882760	883434	.	+	.	ID=gene-Rv0788;Name=purQ;gbkey=Gene;gene=purQ;gene_biotype=protein_coding;locus_tag=Rv0788
AL123456.3	EMBL	CDS	882760	883434	.	+	0	ID=cds-CCP43536.1;Parent=gene-Rv0788;Dbxref=EnsemblGenomes-Gn:Rv0788,EnsemblGenomes-Tr:CCP43536,GOA:P9WHL5,InterPro:IPR010075,InterPro:IPR017926,InterPro:IPR029062,NCBI_GP:CCP43536.1;Name=CCP43536.1;Note=Rv0788%2C (MTCY369.32)%2C len: 224 aa. Probable purQ%2Cphosphoribosylformylglycinamidine synthase I%2C equivalent to MLCB5_24|Z95151|O05756|PURQ phosphoribosylformylglycinamidine synthase I from Mycobacterium leprae (224 aa)%2C FASTA scores: opt: 1341%2CE(): 0%2C (88.7%25 identity in 222 aa overlap). Also highly similar to others e.g. P12041|PURQ_BACSU phosphoribosylformylglycinamidine synthase I from Bacillus subtilis (227 aa)%2C FASTA scores: opt: 691%2C E(): 8.6e-39%2C(47.7%25 identity in 214 aa overlap)%3B etc. Contains PS00442 Glutamine amidotransferases class-I active site. Belongs to type-1 glutamine amidotransferases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purQ;inference=protein motif:PROSITE:PS00442;locus_tag=Rv0788;product=Probable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I);protein_id=CCP43536.1;transl_table=11
AL123456.3	EMBL	gene	883451	884050	.	-	.	ID=gene-Rv0789c;Name=Rv0789c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0789c
AL123456.3	EMBL	CDS	883451	884050	.	-	0	ID=cds-CCP43537.1;Parent=gene-Rv0789c;Dbxref=EnsemblGenomes-Gn:Rv0789c,EnsemblGenomes-Tr:CCP43537,UniProtKB/TrEMBL:I6Y4U0,NCBI_GP:CCP43537.1;Name=CCP43537.1;Note=Rv0789c%2C (MTCY369.33c)%2C len: 199 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0789c;product=Hypothetical protein;protein_id=CCP43537.1;transl_table=11
AL123456.3	EMBL	gene	884072	884800	.	-	.	ID=gene-Rv0790c;Name=Rv0790c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0790c
AL123456.3	EMBL	CDS	884072	884800	.	-	0	ID=cds-CCP43538.1;Parent=gene-Rv0790c;Dbxref=EnsemblGenomes-Gn:Rv0790c,EnsemblGenomes-Tr:CCP43538,InterPro:IPR002931,UniProtKB/TrEMBL:I6XWA9,NCBI_GP:CCP43538.1;Name=CCP43538.1;Note=Rv0790c%2C (MTCY369.34c)%2C len: 242 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0790c;product=Hypothetical protein;protein_id=CCP43538.1;transl_table=11
AL123456.3	EMBL	gene	884797	885840	.	-	.	ID=gene-Rv0791c;Name=Rv0791c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0791c
AL123456.3	EMBL	CDS	884797	885840	.	-	0	ID=cds-CCP43539.1;Parent=gene-Rv0791c;Dbxref=EnsemblGenomes-Gn:Rv0791c,EnsemblGenomes-Tr:CCP43539,GOA:I6X9T8,InterPro:IPR011251,InterPro:IPR019921,UniProtKB/TrEMBL:I6X9T8,NCBI_GP:CCP43539.1;Name=CCP43539.1;Note=Rv0791c%2C (MTV042.01c%2C MTCY369.35c)%2C len: 347 aa. Conserved protein%2C similar (except in N-terminus) to others e.g. CAC44585.1|AL596162 conserved hypothetical protein from Streptomyces coelicolor (307 aa)%3B NP_252643.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (364 aa)%3B etc. Also some similarity with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa)%3B etc. And also similar in part to other proteins from Mycobacterium tuberculosis e.g. Rv1855c|MTCY359.18|Z83859 (307 aa)%2C FASTA scores: opt: 366%2CE(): 4e-16%2C (35.0%25 identity in 226 aa overlap)%3B Rv3079c|MTCY22D7.02|Z83866 conserved hypothetical protein (275 aa)%2C FASTA scores: opt: 342%2C E(): 1.2e-14%2C (31.6%25 identity in 234 aa overlap)%3B Rv0044c possible oxidoreductase (264 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0791c;product=Conserved protein;protein_id=CCP43539.1;transl_table=11
AL123456.3	EMBL	gene	885837	886646	.	-	.	ID=gene-Rv0792c;Name=Rv0792c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0792c
AL123456.3	EMBL	CDS	885837	886646	.	-	0	ID=cds-CCP43540.1;Parent=gene-Rv0792c;Dbxref=EnsemblGenomes-Gn:Rv0792c,EnsemblGenomes-Tr:CCP43540,GOA:O86331,InterPro:IPR000524,InterPro:IPR011663,InterPro:IPR011991,InterPro:IPR028978,UniProtKB/TrEMBL:O86331,NCBI_GP:CCP43540.1;Name=CCP43540.1;Note=Rv0792c%2C (MTV042.02c)%2C len: 269 aa. Probable transcriptional regulator%2C GntR-family%2C similar to many others of GntR family e.g. BSUB0018_189|Z99121 from Bacillus subtilis (243 aa)%2C FASTA scores: opt: 367%2C E(): 1.5e-17%2C (32.1%25 identity in 246 aa overlap)%3B P31453|YIDP_ECOLI from Escherichia coli (238 aa)%2C FASTA scores: opt: 236%2C E(): 8.8e-09%2C (26.4%25 identity in 235 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0792c;product=Probable transcriptional regulatory protein (probably GntR-family);protein_id=CCP43540.1;transl_table=11
AL123456.3	EMBL	gene	886719	887024	.	+	.	ID=gene-Rv0793;Name=Rv0793;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0793
AL123456.3	EMBL	CDS	886719	887024	.	+	0	ID=cds-CCP43541.1;Parent=gene-Rv0793;Dbxref=EnsemblGenomes-Gn:Rv0793,EnsemblGenomes-Tr:CCP43541,GOA:O86332,InterPro:IPR007138,InterPro:IPR011008,PDB:1Y0H,NCBI_GP:CCP43541.1;Name=CCP43541.1;Note=Rv0793%2C (MTV042.03)%2C len: 101 aa. Possible monooxygenase (See Lemieux et al.%2C 2005). Similar to e.g. NP_250888.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (114 aa)%3B AE 001908|AE001908_7 hypothetical protein from Deinococcus radiodurans (101 aa)%2C FASTA scores: opt: 215%2C E(): 3.1e-09%2C (40.4%25 identity in 99 aa overlap)%3B NP_440966.1|NC_000911|D90908|PCC6803|D90908_2 unknown protein from Synechocystis sp. strain PCC 6803 (147 aa)%2C FASTA scores: opt: 194%2C E(): 4.5e-08%2C (31.1%25 identity in 90 aa overlap)%3B etc. Also similar to Rv2749|MTV002.14|AL0089|MTV002_15 conserved hypothetical protein from Mycobacterium tuberculosis (104 aa)%2C FASTA scores: opt: 143%2C E(): 0.00026%2C (26.9%25 identity in 93 aa overlap).;gbkey=CDS;locus_tag=Rv0793;product=Possible monooxygenase;protein_id=CCP43541.1;transl_table=11
AL123456.3	EMBL	gene	887137	888636	.	-	.	ID=gene-Rv0794c;Name=Rv0794c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0794c
AL123456.3	EMBL	CDS	887137	888636	.	-	0	ID=cds-CCP43542.1;Parent=gene-Rv0794c;Dbxref=EnsemblGenomes-Gn:Rv0794c,EnsemblGenomes-Tr:CCP43542,GOA:I6Y4U4,InterPro:IPR001327,InterPro:IPR004099,InterPro:IPR013027,InterPro:IPR016156,InterPro:IPR023753,UniProtKB/TrEMBL:I6Y4U4,NCBI_GP:CCP43542.1;Name=CCP43542.1;Note=Rv0794c%2C (MTV042.04c)%2C len: 499 aa. Probable oxidoreductase%2C possibly dihydrolipoamide dehydrogenase or mercuric reductase. Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Streptomyces coelicolor (477 aa)%3B and similar to various oxidoreductases e.g. P08663|MERA_STAAU mercuric reductase (HG(II) reductase) from Staphylococcus aureus (547 aa)%3B AAK70920.1|AC087551_19|AC087551 putative lipoamide dehydrogenase from Oryza sativa (563 aa)%3B NP_437349.1|NC_003078 putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase%2C similar to mercuric reductases protein from Sinorhizobium meliloti (473 aa)%3B Q04829|DLDH_HALVO dihydrolipoamide dehydrogenase from Haloferax volcanii (475 aa)%3B P08332|MERA_SHIFL mercuric reductase (564 aa)%2C FASTA scores: opt: 522%2C E(): 3.7e-26%2C(31.7%25 identity in 467 aa overlap)%3B P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096 dihydrolipoamide dehydrogenase from Synechocystis sp. strain PCC 6803 (474 aa)%2C FASTA scores: opt: 602%2C E(): 2.3e-31%2C (31.0%25 identity in 493 aa overlap)%3B etc. Note that previously known as lpdB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0794c;product=Probable oxidoreductase;protein_id=CCP43542.1;transl_table=11
AL123456.3	EMBL	repeat_region	889017	889020	.	+	.	ID=id-AL123456.3:889017..889020;Note=4 bp direct repeat: GAGG%2C at the right end of IS6110;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	889021	890375	.	+	.	ID=id-AL123456.3:889021..890375;Note=IS6110-1%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-1
AL123456.3	EMBL	repeat_region	889021	889048	.	+	.	ID=id-AL123456.3:889021..889048;Note=28 bp inverted repeat at the left end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	889072	889398	.	+	.	ID=gene-Rv0795;Name=Rv0795;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0795
AL123456.3	EMBL	CDS	889072	889398	.	+	0	ID=cds-CCP43543.1;Parent=gene-Rv0795;Dbxref=EnsemblGenomes-Gn:Rv0795,EnsemblGenomes-Tr:CCP43543,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP43543.1;Name=CCP43543.1;Note=Rv0795%2C (MTV042.05)%2C len: 108 aa. Putative transposase for IS6110 (fragment)%2C identical to Q50686 insertion element IS6110 (108 aa)%2C FASTA score: (100.0 %25 identity in 108 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv0795 and Rv0796%2C the sequence UUUUAAAG (directly upstream of Rv0796) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0795;product=Putative transposase for insertion sequence element IS6110 (fragment);protein_id=CCP43543.1;transl_table=11
AL123456.3	EMBL	gene	889347	890333	.	+	.	ID=gene-Rv0796;Name=Rv0796;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0796;partial=true;start_range=.,889347
AL123456.3	EMBL	CDS	889347	890333	.	+	0	ID=cds-CCP43544.1;Parent=gene-Rv0796;Dbxref=EnsemblGenomes-Gn:Rv0796,EnsemblGenomes-Tr:CCP43544,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP43544.1;Name=CCP43544.1;Note=Rv0796%2C (MTV042.06)%2C len: 328 aa. Putative transposase for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv0795 and Rv0796%2C the sequence UUUUAAAG (directly upstream of Rv0796) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 50 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0796;partial=true;product=Putative transposase for insertion sequence element IS6110;protein_id=CCP43544.1;start_range=.,889347;transl_table=11
AL123456.3	EMBL	repeat_region	890348	890375	.	-	.	ID=id-AL123456.3:890348..890375;Note=28 bp inverted repeat at the right end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	890376	890379	.	+	.	ID=id-AL123456.3:890376..890379;Note=4 bp direct repeat: GAGG%2C at the left end of IS6110;gbkey=repeat_region
AL123456.3	EMBL	gene	890388	891482	.	+	.	ID=gene-Rv0797;Name=Rv0797;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0797
AL123456.3	EMBL	CDS	890388	891482	.	+	0	ID=cds-CCP43545.1;Parent=gene-Rv0797;Dbxref=EnsemblGenomes-Gn:Rv0797,EnsemblGenomes-Tr:CCP43545,GOA:O07182,InterPro:IPR002525,InterPro:IPR003346,UniProtKB/TrEMBL:O07182,NCBI_GP:CCP43545.1;Name=CCP43545.1;Note=Rv0797%2C (MTCI249B.03c%2C MTV042.07)%2C len: 364 aa. Putative transposase for IS1547%3B almost identical to (but 20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium tuberculosis (383 aa). Also similar to other transposases e.g. MAIS1110A _1|Q48909 transposase from Mycobacterium avium (464 aa)%2C FASTA scores: opt: 226%2C E(): 2.4e-08%2C(30.7%25 identity in 199 aa overlap). Also slight similarity to Rv2014|MTCY39.03c from Mycobacterium tuberculosis (222 aa)%2C FASTA score: (24.8%25 identity in 141 aa overlap).;gbkey=CDS;locus_tag=Rv0797;product=Putative transposase for insertion sequence element IS1547;protein_id=CCP43545.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	890388	891479	.	+	.	ID=id-Rv0797;Note=IS1547-1%2C len: 1092 nt. Insertion sequence IS1547.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1547-1
AL123456.3	EMBL	gene	891472	892269	.	-	.	ID=gene-Rv0798c;Name=cfp29;gbkey=Gene;gene=cfp29;gene_biotype=protein_coding;locus_tag=Rv0798c
AL123456.3	EMBL	CDS	891472	892269	.	-	0	ID=cds-CCP43546.1;Parent=gene-Rv0798c;Dbxref=EnsemblGenomes-Gn:Rv0798c,EnsemblGenomes-Tr:CCP43546,GOA:I6WZG6,InterPro:IPR007544,UniProtKB/TrEMBL:I6WZG6,NCBI_GP:CCP43546.1;Name=CCP43546.1;Note=Rv0798c%2C (MTCI429B.02)%2C len: 265 aa. Cfp29%2C 29 kDa antigen (see citations below). Highly similar to Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from Brevibacterium linens (266 aa)%2C FASTA scores: (58.5%25 identity in 265 aa overlap). Also shows similarity with NP_228594.1|NC_000853 bacteriocin from Thermotoga maritima (262 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cfp29;locus_tag=Rv0798c;product=29 KDa antigen CFP29;protein_id=CCP43546.1;transl_table=11
AL123456.3	EMBL	gene	892266	893273	.	-	.	ID=gene-Rv0799c;Name=Rv0799c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0799c
AL123456.3	EMBL	CDS	892266	893273	.	-	0	ID=cds-CCP43547.1;Parent=gene-Rv0799c;Dbxref=EnsemblGenomes-Gn:Rv0799c,EnsemblGenomes-Tr:CCP43547,GOA:I6Y4U9,InterPro:IPR006314,InterPro:IPR011008,UniProtKB/TrEMBL:I6Y4U9,NCBI_GP:CCP43547.1;Name=CCP43547.1;Note=Rv0799c%2C (MTCY07H7A.10%2C MTCI429B.01)%2C len: 335 aa. Conserved protein%2C similar to Q50021|U2266C from Mycobacterium leprae (146 aa)%2C FASTA scores: opt: 147%2C E(): 0.0016%2C (33.3%25 identity in 117 aa overlap)%3B Q50020|U2266B from Mycobacterium leprae (27 aa)%2C FASTA scores: opt: 94%2CE(): 1.3%2C (56.5%25 identity in 23 aa overlap). Also highly similar to others e.g. CAC01593.1|AL391041 conserved hypothetical protein from Streptomyces coelicolor (316 aa)%3B AF088897|AF088897_9 hypothetical protein from Zymomonas mobilis (322 aa)%2C FASTA scores: opt: 1132%2C E(): 0%2C (56.1%25 identity in 303 aa overlap)%3B P76536|ECAE000330_8 hypothetical protein from Escherichia coli strain K-12 (308 aa)%2C FASTA scores: E(): 2.2e-30%2C (37.4%25 identity in 297 aa overlap)%3B etc. Also similar to some tyrA proteins. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0799c;product=Conserved protein;protein_id=CCP43547.1;transl_table=11
AL123456.3	EMBL	gene	893318	894619	.	+	.	ID=gene-Rv0800;Name=pepC;gbkey=Gene;gene=pepC;gene_biotype=protein_coding;locus_tag=Rv0800
AL123456.3	EMBL	CDS	893318	894619	.	+	0	ID=cds-CCP43548.1;Parent=gene-Rv0800;Dbxref=EnsemblGenomes-Gn:Rv0800,EnsemblGenomes-Tr:CCP43548,GOA:P9WHT1,InterPro:IPR001948,InterPro:IPR022984,InterPro:IPR023358,NCBI_GP:CCP43548.1;Name=CCP43548.1;Note=Rv0800%2C (MTCY07H7A.09c)%2C len: 433 aa. Probable pepC%2Caminopeptidase I%2C highly similar (but shorter 17 aa) to Q50022|PEPX aminopeptidase from Mycobacterium leprae (443 aa)%2C FASTA scores: opt: 2237%2C E(): 0%2C (78.3%25 identity in 433 aa overlap). Also highly similar to others from Eukaryotes and bacteria%2C e.g. T36482 probable aminopeptidase from Streptomyces coelicolor (432 aa)%2CP14904|AMPL_YEAST vacuolar aminopeptidase I precursor from Saccharomyces cerevisiae (514 aa)%2C FASTA scores: opt: 425%2CE(): 4.8e-21%2C (31.0%25 identity in 445 aa overlap)%3B etc. Also similar to hypothetical proteins e.g. P38821|YHR3_YEAST hypothetical 54.2 kDa protein from Saccharomyces cerevisiae (490 aa)%2C FASTA scores: opt: 429%2C E(): 2.5e-21%2C (34.8%25 identity in 443 aa overlap)%3B etc. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepC;locus_tag=Rv0800;product=Probable aminopeptidase PepC;protein_id=CCP43548.1;transl_table=11
AL123456.3	EMBL	gene	894631	894978	.	+	.	ID=gene-Rv0801;Name=Rv0801;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0801
AL123456.3	EMBL	CDS	894631	894978	.	+	0	ID=cds-CCP43549.1;Parent=gene-Rv0801;Dbxref=EnsemblGenomes-Gn:Rv0801,EnsemblGenomes-Tr:CCP43549,InterPro:IPR025870,InterPro:IPR029068,UniProtKB/TrEMBL:O06633,NCBI_GP:CCP43549.1;Name=CCP43549.1;Note=Rv0801%2C (MTCY07H7A.08c)%2C len: 115 aa. Conserved protein%2C similar to many hypothetical proteins from Streptomyces sp. e.g. SCD840A.20|AB81865.1|AL161691 hypothetical protein from Streptomyces coelicolor (145 aa)%3B AF072709|AF072709_8 from Streptomyces lividans (131 aa)%2CFASTA scores: opt: 120%2C E(): 0.2%2C (26.3%25 identity in 118 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0801;product=Conserved protein;protein_id=CCP43549.1;transl_table=11
AL123456.3	EMBL	gene	894972	895628	.	-	.	ID=gene-Rv0802c;Name=Rv0802c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0802c
AL123456.3	EMBL	CDS	894972	895628	.	-	0	ID=cds-CCP43550.1;Parent=gene-Rv0802c;Dbxref=EnsemblGenomes-Gn:Rv0802c,EnsemblGenomes-Tr:CCP43550,GOA:P9WQG7,InterPro:IPR000182,InterPro:IPR016181,PDB:2VZY,PDB:2VZZ,NCBI_GP:CCP43550.1;Name=CCP43550.1;Note=Rv0802c%2C (MTCY07H7A.07c)%2C len: 218 aa. Possible succinyltransferase in the GNAT (Gcn5-related N-acetyltransferase) family (See Vetting et al.%2C 2008). Shows partial similarity with many acetyltransferases and hypothetical proteins e.g. P96579|BSUB0003_68 probable acetyltransferase from Bacillus subtilis (183 aa)%2C FASTA scores: E(): 0.0044%2C (26.4%25 identity in 110 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0802c;product=Possible succinyltransferase in the GCN5-related N-acetyltransferase family;protein_id=CCP43550.1;transl_table=11
AL123456.3	EMBL	gene	895820	898084	.	+	.	ID=gene-Rv0803;Name=purL;gbkey=Gene;gene=purL;gene_biotype=protein_coding;locus_tag=Rv0803
AL123456.3	EMBL	CDS	895820	898084	.	+	0	ID=cds-CCP43551.1;Parent=gene-Rv0803;Dbxref=EnsemblGenomes-Gn:Rv0803,EnsemblGenomes-Tr:CCP43551,GOA:P9WHL7,InterPro:IPR000728,InterPro:IPR010074,InterPro:IPR010918,InterPro:IPR016188,NCBI_GP:CCP43551.1;Name=CCP43551.1;Note=Rv0803%2C (MTCY07H7A.06c)%2C len: 754 aa. PurL%2Cphosphoribosylformylglycinamidine synthase II (see citations below)%2C equivalent to NP_302451.1|NC_002677 phosphoribosylformylglycinamidine synthase II from Mycobacterium leprae (754 aa). Also highly similar to others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor (752 aa)%3B P12042|PURL_BACSU from Bacillus subtilis (742 aa)%2C FASTA score: (44.7%25 identity in 716 aa)%3B etc. Start was chosen by similarity. Belongs to the FGAMS family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purL;locus_tag=Rv0803;product=Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II);protein_id=CCP43551.1;transl_table=11
AL123456.3	EMBL	gene	898081	898710	.	+	.	ID=gene-Rv0804;Name=Rv0804;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0804
AL123456.3	EMBL	CDS	898081	898710	.	+	0	ID=cds-CCP43552.1;Parent=gene-Rv0804;Dbxref=EnsemblGenomes-Gn:Rv0804,EnsemblGenomes-Tr:CCP43552,GOA:I6Y4V2,InterPro:IPR003675,InterPro:IPR015837,UniProtKB/TrEMBL:I6Y4V2,NCBI_GP:CCP43552.1;Name=CCP43552.1;Note=Rv0804%2C (MTCY07H7A.05c)%2C len: 209 aa. Conserved hypothetical protein%2C showing similarity with C-terminus of Rv1863c|MTCY359.10 conserved hypothetical protein from Mycobacterium tuberculosis (256 aa)%2C FASTA scores: opt: 199%2C E(): 1.2e-05%2C (33.2%25 identity in 220 aa overlap)%3B and Rv0658c. Contains PS01151 Fimbrial biogenesis outer membrane usher protein signature.;gbkey=CDS;inference=protein motif:PROSITE:PS01151;locus_tag=Rv0804;product=Conserved hypothetical protein;protein_id=CCP43552.1;transl_table=11
AL123456.3	EMBL	gene	898831	899787	.	+	.	ID=gene-Rv0805;Name=Rv0805;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0805
AL123456.3	EMBL	CDS	898831	899787	.	+	0	ID=cds-CCP43553.1;Parent=gene-Rv0805;Dbxref=EnsemblGenomes-Gn:Rv0805,EnsemblGenomes-Tr:CCP43553,GOA:P9WP65,InterPro:IPR004843,InterPro:IPR026575,InterPro:IPR029052,PDB:2HY1,PDB:2HYO,PDB:2HYP,PDB:3IB7,PDB:3IB8,NCBI_GP:CCP43553.1;Name=CCP43553.1;Note=Rv0805%2C (MTCY07H7A.04c)%2C len: 318 aa. Cyclic nucleotide phosphodiesterase (cNMP PDE) (See Shenoy et al.%2C2005)%2C member of binuclear metallophosphoesterase superfamily%2C equivalent to Q50024 from Mycobacterium leprae (317 aa)%2C FASTA scores: opt: 1713%2C E(): 0%2C (82.5%25 identity in 315 aa overlap). Also shows similarity with hypothetical proteins and icc proteins e.g. SC9B1.22c|T35867 hypothetical protein from Streptomyces coelicolor (305 aa)%3B P36650|ICC_ECOLI icc protein from Escherichia coli (275 aa)%2C FASTA scores: opt: 310%2C E(): 8.9e-14%2C (31.3%25 identity in 214 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0805;product=Class III cyclic nucleotide phosphodiesterase (cNMP PDE);protein_id=CCP43553.1;transl_table=11
AL123456.3	EMBL	gene	899732	901330	.	-	.	ID=gene-Rv0806c;Name=cpsY;gbkey=Gene;gene=cpsY;gene_biotype=protein_coding;locus_tag=Rv0806c
AL123456.3	EMBL	CDS	899732	901330	.	-	0	ID=cds-CCP43554.1;Parent=gene-Rv0806c;Dbxref=EnsemblGenomes-Gn:Rv0806c,EnsemblGenomes-Tr:CCP43554,GOA:P9WGD1,NCBI_GP:CCP43554.1;Name=CCP43554.1;Note=Rv0806c%2C (MTCY07H7A.03)%2C len: 532 aa. Possible cpsY%2CUDP-glucose-4-epimerase%2C equivalent to Q50025|CPSY probable UDP-glucose-4-epimerase from Mycobacterium leprae (542 aa)%2CFASTA scores: opt: 2964%2C E(): 0%2C (82.3%25 identity in 530 aa overlap). Also similar to AAC38286.1|AF019760|SACB CpsY homolog (involved in meningococcal capsule biosynthesis) from Neisseria meningitidis serogroup a (545 aa)%3B Q51151 capsule gene complex UPD-glucose-4-epimerase (gale) from Neisseria meningitidis (373 aa)%2C FASTA scores: opt: 496%2CE(): 9.5e-27%2C (29.3%25 identity in 358 aa overlap)%3B C-terminus of CAB75373.1|AL139298 putative transferase from Streptomyces coelicolor (942 aa)%3B and many hypothetical proteins from Streptomyces coelicolor. Seems to belong to the sugar epimerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cpsY;locus_tag=Rv0806c;product=Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase);protein_id=CCP43554.1;transl_table=11
AL123456.3	EMBL	gene	901635	902024	.	+	.	ID=gene-Rv0807;Name=Rv0807;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0807
AL123456.3	EMBL	CDS	901635	902024	.	+	0	ID=cds-CCP43555.1;Parent=gene-Rv0807;Dbxref=EnsemblGenomes-Gn:Rv0807,EnsemblGenomes-Tr:CCP43555,UniProtKB/TrEMBL:I6Y8U3,NCBI_GP:CCP43555.1;Name=CCP43555.1;Note=Rv0807%2C (MTCY07H7A.02c)%2C len: 129 aa. Conserved hypothetical protein%2C equivalent to O05761|MLCB5_31 hypothetical 14.0 kDa protein from Mycobacterium leprae (131 aa)%2C FASTA scores: E(): 0%2C (73.4%25 identity in 128 aa overlap). Also highly similar to BAA89438.1|AB003158|ORF3 hypothetical protein from Corynebacterium ammoniagenes (132 aa)%3B and C-terminus of SCD25.20|CAB56364.1|AL118514 hypothetical protein from Streptomyces coelicolor (202 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0807;product=Conserved hypothetical protein;protein_id=CCP43555.1;transl_table=11
AL123456.3	EMBL	gene	902111	903694	.	+	.	ID=gene-Rv0808;Name=purF;gbkey=Gene;gene=purF;gene_biotype=protein_coding;locus_tag=Rv0808
AL123456.3	EMBL	CDS	902111	903694	.	+	0	ID=cds-CCP43556.1;Parent=gene-Rv0808;Dbxref=EnsemblGenomes-Gn:Rv0808,EnsemblGenomes-Tr:CCP43556,GOA:P9WHQ7,InterPro:IPR000836,InterPro:IPR005854,InterPro:IPR017932,InterPro:IPR029055,InterPro:IPR029057,NCBI_GP:CCP43556.1;Name=CCP43556.1;Note=Rv0808%2C (MTCY07H7A.01c)%2C len: 527 aa. PurF%2Camidophosphoribosyltransferase%2C equivalent to MLCB5_32|Q50028|PURF from Mycobacterium leprae (556 aa)%2CFASTA scores: (91.3%25 identity in 518 aa overlap)%3B and CAB96578.1|AJ278609 phosphoribosyl pyrophosphate amidotransferase from Mycobacterium smegmatis (511 aa)(see citation below). Also highly similar to others e.g. BAA89439.1|AB003158 amidophosphoribosyl transferase from Corynebacterium ammoniagenes (490 aa)%3B P00497|PUR1_BACSU amidophosphoribosyltransferase precursor from Bacillus subtilis (476 aa)%2C FASTA scores: opt: 1412%2C E(): 0%2C (46.2%25 identity in 470 aa overlap)%3B etc. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Belongs to the purine/pyrimidine phosphoribosyltransferase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purF;inference=protein motif:PROSITE:PS00103;locus_tag=Rv0808;product=Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase);protein_id=CCP43556.1;transl_table=11
AL123456.3	EMBL	gene	903725	904819	.	+	.	ID=gene-Rv0809;Name=purM;gbkey=Gene;gene=purM;gene_biotype=protein_coding;locus_tag=Rv0809
AL123456.3	EMBL	CDS	903725	904819	.	+	0	ID=cds-CCP43557.1;Parent=gene-Rv0809;Dbxref=EnsemblGenomes-Gn:Rv0809,EnsemblGenomes-Tr:CCP43557,GOA:I6Y4V6,InterPro:IPR000728,InterPro:IPR004733,InterPro:IPR010918,InterPro:IPR016188,UniProtKB/TrEMBL:I6Y4V6,NCBI_GP:CCP43557.1;Name=CCP43557.1;Note=Rv0809%2C (MTV043.01)%2C len: 364 aa. Probable purM%2C5'-phosphoribosyl-5-aminoimidazole synthetase%2C equivalent to NP_302446.1|NC_002677 5'-phosphoribosyl-5-aminoimidazole synthase from Mycobacterium leprae (364 aa). Also highly similar to many e.g. P12043|PUR5_BACSU phosphoribosylformylglycinamidine CYCLO-ligase from Bacillus subtilis (346 aa)%2C FASTA scores: opt: 1023%2C E(): 0%2C (46.5%25 identity in 331 aa overlap)%3B U68765|STU68765_2 from Salmonella typhimurium (345 aa)%2C FASTA scores: opt: 1014%2C E():0%2C (47.6%25 identity in 330 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purM;locus_tag=Rv0809;product=Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase);protein_id=CCP43557.1;transl_table=11
AL123456.3	EMBL	gene	904905	905087	.	-	.	ID=gene-Rv0810c;Name=Rv0810c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0810c
AL123456.3	EMBL	CDS	904905	905087	.	-	0	ID=cds-CCP43558.1;Parent=gene-Rv0810c;Dbxref=EnsemblGenomes-Gn:Rv0810c,EnsemblGenomes-Tr:CCP43558,InterPro:IPR021426,UniProtKB/TrEMBL:I6XWB9,NCBI_GP:CCP43558.1;Name=CCP43558.1;Note=Rv0810c%2C (MTV043.02c)%2C len: 60 aa. Conserved hypothetical protein%2C with its N-terminus highly similar to NP_302445.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (62 aa)%3B and AL118514|SCD25_24 hypothetical protein from Streptomyces coelicolor (84 aa)%2CFASTA scores: opt: 180%2C E(): 5.7e-07%2C (51.8%25 identity in 56 aa overlap).;gbkey=CDS;locus_tag=Rv0810c;product=Conserved hypothetical protein;protein_id=CCP43558.1;transl_table=11
AL123456.3	EMBL	gene	905234	906340	.	-	.	ID=gene-Rv0811c;Name=Rv0811c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0811c
AL123456.3	EMBL	CDS	905234	906340	.	-	0	ID=cds-CCP43559.1;Parent=gene-Rv0811c;Dbxref=EnsemblGenomes-Gn:Rv0811c,EnsemblGenomes-Tr:CCP43559,GOA:I6X9V3,InterPro:IPR006222,InterPro:IPR013977,InterPro:IPR017703,UniProtKB/TrEMBL:I6X9V3,NCBI_GP:CCP43559.1;Name=CCP43559.1;Note=Rv0811c%2C (MTV043.03c)%2C len: 368 aa. Conserved protein%2C equivalent to U2266F|U15182|MLU15182_13 hypothetical protein from Mycobacterium leprae (366 aa)%2CFASTA scores: opt: 1870%2C E(): 0%2C (77.4%25 identity in 367 aa overlap). Also highly similar to BAA89441.1|AB003158|ORF4 hypothetical protein from Corynebacterium ammoniagenes (359 aa)%3B and CAB94085.1|AL358692 conserved hypothetical protein from Streptomyces coelicolor (321 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0811c;product=Conserved protein;protein_id=CCP43559.1;transl_table=11
AL123456.3	EMBL	gene	906423	907292	.	+	.	ID=gene-Rv0812;Name=Rv0812;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0812
AL123456.3	EMBL	CDS	906423	907292	.	+	0	ID=cds-CCP43560.1;Parent=gene-Rv0812;Dbxref=EnsemblGenomes-Gn:Rv0812,EnsemblGenomes-Tr:CCP43560,GOA:Q79FW0,InterPro:IPR001544,UniProtKB/TrEMBL:Q79FW0,NCBI_GP:CCP43560.1;Name=CCP43560.1;Note=Rv0812%2C (MTV043.04)%2C len: 289 aa. Probable amino acid aminotransferase%2C similar to other amino acid aminotransferases%2C generelly class-IV of pyridoxal-phosphate-dependent aminotransferases%2C and especially ILVE proteins and PABC proteins e.g. B76065.1|AL157953 putative aminotransferase from Streptomyces coelicolor (273 aa)%3B NP_069766.1|NC_000917 branched-chain amino acid aminotransferase (ilvE) from Archaeoglobus fulgidus (290 aa)%3B P54692|DAAA_BACLI D-alanine aminotransferase from Bacillus licheniformis (283 aa)%3B P28305|PABC_ECOLI|B1096 4-amino-4-deoxychorismate lyase (ADC lyase) From Escherichia coli strain K12 (269 aa)%2C FASTA scores: opt: 165%2C E(): 0.00064%2C (26.8%25 identity in 198 aa overlap)%3B etc. Note that previously known as pabC.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0812;product=Probable amino acid aminotransferase;protein_id=CCP43560.1;transl_table=11
AL123456.3	EMBL	gene	907338	908018	.	-	.	ID=gene-Rv0813c;Name=Rv0813c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0813c
AL123456.3	EMBL	CDS	907338	908018	.	-	0	ID=cds-CCP43561.1;Parent=gene-Rv0813c;Dbxref=EnsemblGenomes-Gn:Rv0813c,EnsemblGenomes-Tr:CCP43561,GOA:P9WFG9,InterPro:IPR011038,InterPro:IPR014878,InterPro:IPR022939,PDB:2FWV,NCBI_GP:CCP43561.1;Name=CCP43561.1;Note=Rv0813c%2C (MTV043.05c)%2C len: 226 aa. Conserved protein%2C highly similar to U15182|MLU15182_16 hypothetical protein from Mycobacterium leprae (242 aa)%2C FASTA scores: opt: 1191%2C E(): 0%2C (78.3%25 identity in 226 aa overlap)%3B and NP_302442.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (228 aa). Also similar to AB94083.1|AL358692|SCD66.16 hypothetical protein from Streptomyces coelicolor (191 aa)%3B and Rv2717c|MTCY05A6_37 hypothetical protein from Mycobacterium tuberculosis (164 aa)%2C FASTA score: (30.4%25 identity in 171 aa overlap). Possibly a new bacterial family of fatty acid-binding protein-like proteins (See Shepard et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0813c;product=Conserved protein;protein_id=CCP43561.1;transl_table=11
AL123456.3	EMBL	gene	908181	908483	.	-	.	ID=gene-Rv0814c;Name=sseC2;gbkey=Gene;gene=sseC2;gene_biotype=protein_coding;locus_tag=Rv0814c
AL123456.3	EMBL	CDS	908181	908483	.	-	0	ID=cds-CCP43562.1;Parent=gene-Rv0814c;Dbxref=EnsemblGenomes-Gn:Rv0814c,EnsemblGenomes-Tr:CCP43562,GOA:P0CG95,InterPro:IPR008969,InterPro:IPR010814,InterPro:IPR014766,NCBI_GP:CCP43562.1;Name=CCP43562.1;Note=Rv0814c%2C (MTV043.06c%2C O05794)%2C len: 100 aa. SseC2%2Cconserved protein%2C highly similar to AAA62972.1|U15182|MLU15182_17 hypothetical protein from Mycobacterium leprae (143 aa)%2C FASTA scores: opt: 545%2C E(): 0%2C (84.0%25 identity in 100 aa overlap)%3B and NP_302441.1|NC_002677|Z95150|MTCY164_29 conserved hypothetical protein from Mycobacterium leprae (100 aa)%2CFASTA scores: opt: 647%2C E(): 0%2C (100.0%25 identity in 100 aa overlap). Also highly similar to M29612|SERCYSA_5 rhodanese-like protein from Saccharopolyspora erythraea (101 aa)%2C FASTA scores: opt: 345%2C E(): 1.2e-18%2C (57.1%25 identity in 98 aa overlap)%3B and similar at the C-terminus to the C-terminus of CAB94069.1|AL358692 conserved hypothetical protein from Streptomyces coelicolor (95 aa). Identical second copy present as Rv3118|MTCY164.28|SSEC1 from Mycobacterium tuberculosis (100 aa) (100.0%25 identity in 100 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sseC2;locus_tag=Rv0814c;product=Conserved protein SseC2;protein_id=CCP43562.1;transl_table=11
AL123456.3	EMBL	gene	908485	909318	.	-	.	ID=gene-Rv0815c;Name=cysA2;gbkey=Gene;gene=cysA2;gene_biotype=protein_coding;gene_synonym=sseC4;locus_tag=Rv0815c
AL123456.3	EMBL	CDS	908485	909318	.	-	0	ID=cds-CCP43563.1;Parent=gene-Rv0815c;Dbxref=EnsemblGenomes-Gn:Rv0815c,EnsemblGenomes-Tr:CCP43563,GOA:P9WHF9,InterPro:IPR001307,InterPro:IPR001763,PDB:3AAX,PDB:3AAY,PDB:3HWI,NCBI_GP:CCP43563.1;Name=CCP43563.1;Note=Rv0815c%2C (MTV043.07c%2C MT0837%2C O05793)%2C len: 277 aa. Probable cysA2 (alternate gene name: sseC4)%2C thiosulfate sulfurtransferase (see Wooff et al.%2C 2002)%2C equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE putative sulfurtransferase thiosulfate from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER putative thiosulfate sulfurtransferase from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa)%3B NP_293941.1|NC_001263 thiosulfate sulfurtransferase from Deinococcus radiodurans (286 aa)%3B etc. Identical second copy present as Rv3117|MTCY164.27|MT3199|O05793|cysA3 (277 aa) (100.0%25 identity in 277 aa overlap). Contains PS00683 Rhodanese C-terminal signature at C-terminus. Belongs to the rhodanese family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysA2;inference=protein motif:PROSITE:PS00683;locus_tag=Rv0815c;product=Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase);protein_id=CCP43563.1;transl_table=11
AL123456.3	EMBL	gene	909611	910033	.	-	.	ID=gene-Rv0816c;Name=thiX;gbkey=Gene;gene=thiX;gene_biotype=protein_coding;locus_tag=Rv0816c
AL123456.3	EMBL	CDS	909611	910033	.	-	0	ID=cds-CCP43564.1;Parent=gene-Rv0816c;Dbxref=EnsemblGenomes-Gn:Rv0816c,EnsemblGenomes-Tr:CCP43564,GOA:I6Y8V2,InterPro:IPR005746,InterPro:IPR012336,InterPro:IPR013766,UniProtKB/TrEMBL:I6Y8V2,NCBI_GP:CCP43564.1;Name=CCP43564.1;Note=Rv0816c%2C (MTV043.08c)%2C len: 140 aa. Probable thiX%2Cthioredoxin%2C equivalent to ThiX|U15182|MLU15182_21 thioredoxin from Mycobacterium leprae (172 aa)%2C FASTA scores: opt: 556%2C E(): 8.8e-31%2C (63.8%25 identity in 141 aa overlap)%3B and similar to AAL08576.1|AF418548_2|AF418548 thioredoxin from Mycobacterium avium subsp. paratuberculosis (117 aa). Also similar to other bacterial thioredoxins e.g. CAB95303.1|AL359779 putative thioredoxin from Streptomyces coelicolor (126 aa)%3B P33791|THIO_STRAU|TRX|TRXA thioredoxin from Streptomyces aureofaciens (106 aa)%3B etc. And similar to Rv3914|MT4033|MTV028.05|NP_218431.1|NC_000962|trxC thioredoxin (TRX) (MPT46) from Mycobacterium tuberculosis (116 aa). Has hydrophobic stretch at N-terminus. Seems to belong to the thioredoxin family.;gbkey=CDS;gene=thiX;locus_tag=Rv0816c;product=Probable thioredoxin ThiX;protein_id=CCP43564.1;transl_table=11
AL123456.3	EMBL	gene	910030	910842	.	-	.	ID=gene-Rv0817c;Name=Rv0817c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0817c
AL123456.3	EMBL	CDS	910030	910842	.	-	0	ID=cds-CCP43565.1;Parent=gene-Rv0817c;Dbxref=EnsemblGenomes-Gn:Rv0817c,EnsemblGenomes-Tr:CCP43565,InterPro:IPR021373,UniProtKB/TrEMBL:I6WZH9,NCBI_GP:CCP43565.1;Name=CCP43565.1;Note=Rv0817c%2C (MTV043.09c)%2C len: 270 aa. Probable conserved exported protein%2C with N-terminal signal sequence%2C equivalent (but shorter 13 aa) to U15182|MLU15182_22|U2266M probable exported protein from Mycobacterium leprae (283 aa)%2C FASTA scores: opt: 1287%2CE(): 0%2C (73.0%25 identity in 270 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0817c;product=Probable conserved exported protein;protein_id=CCP43565.1;transl_table=11
AL123456.3	EMBL	gene	910972	911739	.	+	.	ID=gene-Rv0818;Name=Rv0818;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0818
AL123456.3	EMBL	CDS	910972	911739	.	+	0	ID=cds-CCP43566.1;Parent=gene-Rv0818;Dbxref=EnsemblGenomes-Gn:Rv0818,EnsemblGenomes-Tr:CCP43566,GOA:O53830,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,InterPro:IPR016032,PDB:4O1I,UniProtKB/TrEMBL:O53830,NCBI_GP:CCP43566.1;Name=CCP43566.1;Note=Rv0818%2C (MTV043.10)%2C len: 255 aa. Probable transcriptional regulatory protein%2C highly similar to Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c transcriptional regulatory protein from Streptomyces coelicolor (267 aa)%2C FASTA scores: opt: 945%2C E(): 0%2C (61.5 identity in 239 aa overlap)%3B and similar to others from other organisms. Also similar to Rv2884|MTCY274.15|Z74024 from Mycobacterium tuberculosis (252 aa)%2C FASTA scores: opt: 662%2C E(): 0%2C (47.8%25 identity in 226 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0818;product=Transcriptional regulatory protein;protein_id=CCP43566.1;transl_table=11
AL123456.3	EMBL	gene	911736	912683	.	+	.	ID=gene-Rv0819;Name=mshD;gbkey=Gene;gene=mshD;gene_biotype=protein_coding;locus_tag=Rv0819
AL123456.3	EMBL	CDS	911736	912683	.	+	0	ID=cds-CCP43567.1;Parent=gene-Rv0819;Dbxref=EnsemblGenomes-Gn:Rv0819,EnsemblGenomes-Tr:CCP43567,GOA:P9WJM7,InterPro:IPR000182,InterPro:IPR016181,InterPro:IPR017813,PDB:1OZP,PDB:1P0H,PDB:2C27,NCBI_GP:CCP43567.1;Name=CCP43567.1;Note=Rv0819%2C (MTV043.11)%2C len: 315 aa. MshD%2Cacetyltransferase involved in mycothiol synthesis (see Koledin et al.%2C 2002). Contains two GNAT (Gcn5-related N-acetyltransferase) domains. See Vetting et al. 2003%2C2005%2C 2006. Equivalent to U2266N|U15182|MLU15182_24 hypothetical protein from Mycobacterium leprae (312 aa)%2CFASTA scores: opt: 1540%2C E(): 0%2C (75.2%25 identity in 314 aa overlap). Also highly similar to CAB88484.1|AL353816 putative acetyltransferase from Streptomyces coelicolor (309 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mshD;locus_tag=Rv0819;product=GCN5-related N-acetyltransferase%2C MshD;protein_id=CCP43567.1;transl_table=11
AL123456.3	EMBL	gene	912726	913502	.	+	.	ID=gene-Rv0820;Name=phoT;gbkey=Gene;gene=phoT;gene_biotype=protein_coding;locus_tag=Rv0820
AL123456.3	EMBL	CDS	912726	913502	.	+	0	ID=cds-CCP43568.1;Parent=gene-Rv0820;Dbxref=EnsemblGenomes-Gn:Rv0820,EnsemblGenomes-Tr:CCP43568,GOA:P9WQL1,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR005670,InterPro:IPR015850,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP43568.1;Name=CCP43568.1;Note=Rv0820%2C (MTV043.12)%2C len: 258 aa. Probable phoT%2Cphosphate-transport ATP-binding protein ABC transporter (see citation below)%2C equivalent to PhoT|MLU15182_28|U15182 phosphate transport system ABC transporter from Mycobacterium leprae (258 aa)%2C FASTA scores: opt: 1556%2CE(): 0%2C (91.5%25 identity in 258 aa overlap). Also highly similar to others e.g. CAB88472.1|AL353816 phosphate ABC transport system ATP-binding protein from Streptomyces coelicolor (258 aa)%3B etc. Note that also highly similar to many PstB proteins e.g. AAC15686.1|AF045938|PstB putative ABC transporter nucleotide binding subunit from Mycobacterium smegmatis (258 aa). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;gbkey=CDS;gene=phoT;inference=protein motif:PROSITE:PS00211;locus_tag=Rv0820;product=Probable phosphate-transport ATP-binding protein ABC transporter PhoT;protein_id=CCP43568.1;transl_table=11
AL123456.3	EMBL	gene	913558	914199	.	-	.	ID=gene-Rv0821c;Name=phoY2;gbkey=Gene;gene=phoY2;gene_biotype=protein_coding;locus_tag=Rv0821c
AL123456.3	EMBL	CDS	913558	914199	.	-	0	ID=cds-CCP43569.1;Parent=gene-Rv0821c;Dbxref=EnsemblGenomes-Gn:Rv0821c,EnsemblGenomes-Tr:CCP43569,GOA:P9WI95,InterPro:IPR026022,InterPro:IPR028366,NCBI_GP:CCP43569.1;Name=CCP43569.1;Note=Rv0821c%2C (MTV043.13c)%2C len: 213 aa. Probable phoY2%2Cphosphate-transport system regulatory protein%2C highly similar to PhoY|MLU15182_29|U15182 phosphate transport system regulator from Mycobacterium leprae (222 aa)%2C FASTA scores: opt: 1268%2C E(): 0%2C (93.0%25 identity in 213 aa overlap). Also similar to others e.g. NP_384620.1|NC_003047 probable phosphate transport system transcriptional regulator protein from Sinorhizobium meliloti (237 aa)%3B etc. Also highly similar to MTCI418A.03c|Z96070|PhoY1 probable phosphate transport system transcriptional regulator protein from Mycobacterium tuberculosis (221 aa)%2CFASTA scores: opt: 937%2C E(): 0%2C (63.4%25 identity in 213 aa overlap). Belongs to the PhoU family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=phoY2;locus_tag=Rv0821c;product=Probable phosphate-transport system transcriptional regulatory protein PhoY2;protein_id=CCP43569.1;transl_table=11
AL123456.3	EMBL	gene	914257	916311	.	-	.	ID=gene-Rv0822c;Name=Rv0822c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0822c
AL123456.3	EMBL	CDS	914257	916311	.	-	0	ID=cds-CCP43570.1;Parent=gene-Rv0822c;Dbxref=EnsemblGenomes-Gn:Rv0822c,EnsemblGenomes-Tr:CCP43570,InterPro:IPR004474,InterPro:IPR027381,UniProtKB/TrEMBL:I6WZI4,NCBI_GP:CCP43570.1;Name=CCP43570.1;Note=Rv0822c%2C (MTV043.14c)%2C len: 684 aa. Conserved protein%2C highly similar in the region between aa 370 - 580 to U2266O|U15182|MLU15182_30 hypothetical protein from Mycobacterium leprae (222 aa)%2C FASTA scores: opt: 819%2C E(): 0%2C (60.6%25 identity in 221 aa overlap). More extended similarity to Rv3267|Z92771|MTCY71_7 from Mycobacterium tuberculosis (498 aa)%2C FASTA scores: opt: 434%2C E(): 2.2e-17%2C (26.6%25 identity in 541 aa overlap)%2C and Rv3484. Also similar to various proteins%2C preferiously putative membrane proteins and membrane-bound regulatory proteins e.g. CAC44512.1|AL596138 putative membrane protein from Streptomyces coelicolor (524 aa)%3B U56901|BSU56901_1 regulatory protein from Bacillus subtilis (391 aa)%2C FASTA scores: opt: 225%2C E(): 1.3e-05%2C (24.7%25 identity in 340 aa overlap). Contains hydrophobic stretch (aa ~~ 160-195) and PS00041 Bacterial regulatory proteins%2C araC family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00041;locus_tag=Rv0822c;product=Conserved protein;protein_id=CCP43570.1;transl_table=11
AL123456.3	EMBL	gene	916477	917646	.	-	.	ID=gene-Rv0823c;Name=Rv0823c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0823c
AL123456.3	EMBL	CDS	916477	917646	.	-	0	ID=cds-CCP43571.1;Parent=gene-Rv0823c;Dbxref=EnsemblGenomes-Gn:Rv0823c,EnsemblGenomes-Tr:CCP43571,GOA:P9WNS7,InterPro:IPR001269,InterPro:IPR004652,InterPro:IPR013785,InterPro:IPR018517,InterPro:IPR024036,NCBI_GP:CCP43571.1;Name=CCP43571.1;Note=Rv0823c%2C (MTV043.15c)%2C len: 389 aa. Possible transcriptional regulator (resembles nitrogen regulation protein)%2C equivalent (but longer 24 aa in N-terminus) to MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium leprae (384 aa)%2C FASTA scores: opt: 2070%2C E(): 0%2C (82.3%25 identity in 384 aa overlap) (see citation below). Also highly similar to CAB63312.1|AL133471|SCC82.03c hypothetical protein from Streptomyces coelicolor (406 aa)%3B and to many transcriptional regulators members of UPF0034 family (NIFR3/SMM1) e.g. D26185|BAC180K_143 protein similar to transcriptional regulator (nitrogen regulation protein) from Bacillus subtilis (333 aa)%2C FASTA scores: opt: 609%2CE(): 1.4e-32%2C (38.3%25 identity in 326 aa overlap)%3B NP_349795.1|NC_003030 NifR3 family enzyme from Clostridium acetobutylicum (321 aa)%3B etc. Contains PS01136 Uncharacterized protein family UPF0034 signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01136;locus_tag=Rv0823c;product=Possible transcriptional regulatory protein;protein_id=CCP43571.1;transl_table=11
AL123456.3	EMBL	gene	917734	918750	.	-	.	ID=gene-Rv0824c;Name=desA1;gbkey=Gene;gene=desA1;gene_biotype=protein_coding;gene_synonym=des;locus_tag=Rv0824c
AL123456.3	EMBL	CDS	917734	918750	.	-	0	ID=cds-CCP43572.1;Parent=gene-Rv0824c;Dbxref=EnsemblGenomes-Gn:Rv0824c,EnsemblGenomes-Tr:CCP43572,GOA:P9WNZ7,InterPro:IPR005067,InterPro:IPR009078,InterPro:IPR012348,NCBI_GP:CCP43572.1;Name=CCP43572.1;Note=Rv0824c%2C (MTV043.16c)%2C len: 338 aa. Probable desA1 (alternate gene name: des)%2C acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (see Jackson et al.%2C1997)%2C equivalent to U15182|MLU15182_32 acyl-[ACP] desaturase from Mycobacterium leprae (338 aa)%2C FASTA scores: opt: 1880%2C E(): 0%2C (79.9%25 identity in 338 aa overlap)%3B and highly similar in part to fragment CAB96061.1|AJ250019 Steroyl-ACP-desaturase from Mycobacterium avium subsp. paratuberculosis (93 aa). Also similar to other fatty acid desaturases e.g. T35035 probable acyl-[acyl-carrier protein] desaturase from Streptomyces coelicolor (328 aa)%3B Q40731|STAD_ORYSA acyl-[acyl-carrier protein] desaturase precursor from Oryza sativa (Rice) (390 aa)%3B etc. Also highly similar to desA2|Rv1094 from Mycobacterium tuberculosis (275 aa). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. Belongs to the fatty acid desaturase family. Cofactor: ferredoxin%2C ferredoxin NADPH reductase%2Cand NADPH. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=desA1;inference=protein motif:PROSITE:PS00225;locus_tag=Rv0824c;product=Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des);protein_id=CCP43572.1;transl_table=11
AL123456.3	EMBL	gene	918264	918458	.	+	.	ID=gene-ASdes;Name=ASdes;gbkey=Gene;gene=ASdes;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	918264	918458	.	+	.	ID=rna-ASdes;Parent=gene-ASdes;Note=ASdes%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 918350 and 918365. Alternate 3'-ends at positions 918432 and 918412.;gbkey=ncRNA;gene=ASdes;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	918264	918458	.	+	.	ID=exon-ASdes-1;Parent=rna-ASdes;Note=ASdes%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 918350 and 918365. Alternate 3'-ends at positions 918432 and 918412.;gbkey=ncRNA;gene=ASdes;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	918912	919553	.	-	.	ID=gene-Rv0825c;Name=Rv0825c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0825c
AL123456.3	EMBL	CDS	918912	919553	.	-	0	ID=cds-CCP43573.1;Parent=gene-Rv0825c;Dbxref=EnsemblGenomes-Gn:Rv0825c,EnsemblGenomes-Tr:CCP43573,GOA:O53836,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:O53836,NCBI_GP:CCP43573.1;Name=CCP43573.1;Note=Rv0825c%2C (MTV043.17c)%2C len: 213 aa. Conserved protein%2C highly similar%2C but in part (between aa ~~43-96) to fadD27|Rv0275c|MTV035.03 putative fatty-acid-CoA ligase from Mycobacterium tuberculosis (241 aa)%2C FASTA scores: E(): 7.3e-09%2C (32.6%25 identity in 190 aa overlap). Also shows similarity with other proteins from Mycobacterium tuberculosis e.g. Rv0078|AL0214|MTV030_22 (201 aa)%2C FASTA scores: opt:118%2C E(): 0.32%2C (34.5%25 identity in 113 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0825c;product=Conserved protein;protein_id=CCP43573.1;transl_table=11
AL123456.3	EMBL	gene	919634	920689	.	+	.	ID=gene-Rv0826;Name=Rv0826;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0826
AL123456.3	EMBL	CDS	919634	920689	.	+	0	ID=cds-CCP43574.1;Parent=gene-Rv0826;Dbxref=EnsemblGenomes-Gn:Rv0826,EnsemblGenomes-Tr:CCP43574,GOA:O53837,InterPro:IPR018713,UniProtKB/TrEMBL:O53837,NCBI_GP:CCP43574.1;Name=CCP43574.1;Note=Rv0826%2C (MTV043.18)%2C len: 351 aa. Conserved hypothetical protein%2C similar to CAB94053.1|AL358672|SC7A12.06 hypothetical protein from Streptomyces coelicolor (300 aa)%3B and NP_421372.1|NC_002696 hypothetical protein from Caulobacter crescentus (299 aa). Also similar to other proteins from Mycobacterium tuberculosis e.g. Rv1645c|Z85982|MTCY06H11.09 (351 aa)%2CFASTA scores: opt: 1199%2C E(): 0%2C (57.5%25 identity in 299 aa overlap)%3B Rv2237%3B Rv0276%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0826;product=Conserved hypothetical protein;protein_id=CCP43574.1;transl_table=11
AL123456.3	EMBL	gene	920741	921133	.	-	.	ID=gene-Rv0827c;Name=kmtR;gbkey=Gene;gene=kmtR;gene_biotype=protein_coding;locus_tag=Rv0827c
AL123456.3	EMBL	CDS	920741	921133	.	-	0	ID=cds-CCP43575.1;Parent=gene-Rv0827c;Dbxref=EnsemblGenomes-Gn:Rv0827c,EnsemblGenomes-Tr:CCP43575,GOA:O53838,InterPro:IPR001845,InterPro:IPR011991,NCBI_GP:CCP43575.1;Name=CCP43575.1;Note=Rv0827c%2C (MTV043.19c)%2C len: 130 aa. KmtR%2Ctranscriptional regulator (See Campbell et al.%2C 2007)%2Csimilar to many e.g. CAC42856.1|AL592292 putative regulatory protein from Streptomyces coelicolor (115 aa)%3B NP_301626.1|NC_002677 putative ArsR-family transcriptional regulator from Mycobacterium leprae (140 aa)%3B BSUB0011_75|O31844|Z99114 YOZA protein from Bacillus subtilis (107 aa)%2C FASTA scores: opt: 208%2C E(): 3.2e-08%2C(35.5%25 identity in 93 aa overlap)%3B etc. Also similar to MTCY27.22c|Z95208 from Mycobacterium tuberculosis (135 aa)%2CFASTA scores: opt: 201%2C E(): 1.2e-07%2C (35.7%25 identity in 98 aa overlap). Contains probable helix-turn helix motif from aa 42-63 (Score 1300%2C +3.61 SD). Belongs to the ArsR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kmtR;locus_tag=Rv0827c;product=Metal sensor transcriptional regulator KmtR (ArsR-SmtB family);protein_id=CCP43575.1;transl_table=11
AL123456.3	EMBL	gene	921191	921613	.	-	.	ID=gene-Rv0828c;Name=Rv0828c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0828c
AL123456.3	EMBL	CDS	921191	921613	.	-	0	ID=cds-CCP43576.1;Parent=gene-Rv0828c;Dbxref=EnsemblGenomes-Gn:Rv0828c,EnsemblGenomes-Tr:CCP43576,GOA:O53839,InterPro:IPR002125,InterPro:IPR016192,InterPro:IPR016193,UniProtKB/TrEMBL:O53839,NCBI_GP:CCP43576.1;Name=CCP43576.1;Note=Rv0828c%2C (MTV043.20c)%2C len: 140 aa. Possible deaminase%2C with its N-terminus highly similar to middle part of NP_302602.1|NC_002677 possible cytidine/deoxycytidylate deaminase from Mycobacterium leprae (171 aa). Also similar to other deaminases e.g. CAC18715.2|AL451182 putative deaminase from Streptomyces coelicolor (167 aa)%3B NP_251189.1|NC_002516 probable deaminase from Pseudomonas aeruginosa (151 aa)%3B NP_108387.1|NC_002678 nitrogen fixation protein gene from Mesorhizobium loti (149 aa)%3B etc. Also similar to many conserved hypothetical proteins e.g. NP_389200.1|NC_000964 hypothetical protein from Bacillus subtilis (156 aa)%2C FASTA scores: E(): 1.3e-07%2C (38.9%25 identity in 95 aa overlap)%3B etc. And similar to Rv3752c possible deaminase from Mycobacterium tuberculosis. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. Belongs to the cytidine and deoxycytidylate deaminases family.;gbkey=CDS;inference=protein motif:PROSITE:PS00903;locus_tag=Rv0828c;product=Possible deaminase;protein_id=CCP43576.1;transl_table=11
AL123456.3	EMBL	gene	921575	921865	.	+	.	ID=gene-Rv0829;Name=Rv0829;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0829
AL123456.3	EMBL	CDS	921575	921865	.	+	0	ID=cds-CCP43577.1;Parent=gene-Rv0829;Dbxref=EnsemblGenomes-Gn:Rv0829,EnsemblGenomes-Tr:CCP43577,InterPro:IPR010095,UniProtKB/TrEMBL:O53840,NCBI_GP:CCP43577.1;Name=CCP43577.1;Note=Rv0829%2C (MTV043.21)%2C len: 96 aa. Possible transposase for IS1605' (fragment)%2C similar to C-terminal end of many mycobacterial transposases and hypothetical proteins e.g. Z74024|MTCY274_16 from Mycobacterium tuberculosis (460 aa)%2C FASTA scores: opt: 668%2C E(): 6.2e-32%2C (98.9%25 identity in 93 aa overlap)%3B MTV002_57|O33333 transposase from Mycobacterium tuberculosis %3B L07627|SERRY1_1 insertion element IS1136 from Saccharopolyspora erythraea (90 aa)%2C FASTA score: (34.9%25 identity in 83 aa overlap).;gbkey=CDS;locus_tag=Rv0829;product=Possible transposase (fragment);protein_id=CCP43577.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	921575	921862	.	+	.	ID=id-Rv0829;Note=IS1605'%2C len: 288 nt. Insertion sequence IS1605'.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1605'
AL123456.3	EMBL	gene	921970	922875	.	+	.	ID=gene-Rv0830;Name=Rv0830;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0830
AL123456.3	EMBL	CDS	921970	922875	.	+	0	ID=cds-CCP43578.1;Parent=gene-Rv0830;Dbxref=EnsemblGenomes-Gn:Rv0830,EnsemblGenomes-Tr:CCP43578,GOA:P9WFI3,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP43578.1;Name=CCP43578.1;Note=Rv0830%2C (MTV043.22)%2C len: 301 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C member of Mycobacterium tuberculosis protein family consisting of the proteins Rv0726c%2C Rv0731c%2C Rv3399%2CRv1729c|Z81360|MTCY4C12_14c (312 aa)%2C FASTA scores: opt: 1014%2C E(): 0%2C (54.1%25 identity in 292 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0830;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP43578.1;transl_table=11
AL123456.3	EMBL	gene	922894	923709	.	-	.	ID=gene-Rv0831c;Name=Rv0831c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0831c
AL123456.3	EMBL	CDS	922894	923709	.	-	0	ID=cds-CCP43579.1;Parent=gene-Rv0831c;Dbxref=EnsemblGenomes-Gn:Rv0831c,EnsemblGenomes-Tr:CCP43579,GOA:O53842,InterPro:IPR026349,UniProtKB/TrEMBL:O53842,NCBI_GP:CCP43579.1;Name=CCP43579.1;Note=Rv0831c%2C (MTV043.23c)%2C len: 271 aa. Conserved protein%2C similar to Rv0347|MTY13E10_7|Z95324 conserved hypothetical protein from Mycobacterium tuberculosis (328 aa)%2C FASTA scores: opt: 426%2C E(): 2.6e-21%2C (33.6%25 identity in 262 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0831c;product=Conserved protein;protein_id=CCP43579.1;transl_table=11
AL123456.3	EMBL	gene	923803	923875	.	-	.	ID=gene-lysT;Name=lysT;gbkey=Gene;gene=lysT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	923803	923875	.	-	.	ID=rna-lysT;Parent=gene-lysT;Note=codon recognized: AAA%3B lysT%2C tRNA-Lys%2C anticodon ttt%2C length %3D 73;anticodon=(pos:complement(923840..923842));gbkey=tRNA;gene=lysT;product=tRNA-Lys
AL123456.3	EMBL	exon	923803	923875	.	-	.	ID=exon-lysT-1;Parent=rna-lysT;Note=codon recognized: AAA%3B lysT%2C tRNA-Lys%2C anticodon ttt%2C length %3D 73;anticodon=(pos:complement(923840..923842));gbkey=tRNA;gene=lysT;product=tRNA-Lys
AL123456.3	EMBL	gene	923999	924072	.	+	.	ID=gene-gluT;Name=gluT;gbkey=Gene;gene=gluT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	923999	924072	.	+	.	ID=rna-gluT;Parent=gene-gluT;Note=codon recognized: GAA%3B gluT%2C tRNA-Glu%2C anticodon ttc%2C length %3D 74;anticodon=(pos:924034..924036);gbkey=tRNA;gene=gluT;product=tRNA-Glu
AL123456.3	EMBL	exon	923999	924072	.	+	.	ID=exon-gluT-1;Parent=rna-gluT;Note=codon recognized: GAA%3B gluT%2C tRNA-Glu%2C anticodon ttc%2C length %3D 74;anticodon=(pos:924034..924036);gbkey=tRNA;gene=gluT;product=tRNA-Glu
AL123456.3	EMBL	gene	924110	924183	.	+	.	ID=gene-aspT;Name=aspT;gbkey=Gene;gene=aspT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	924110	924183	.	+	.	ID=rna-aspT;Parent=gene-aspT;Note=codon recognized: GAC%3B aspT%2C tRNA-Asp%2C anticodon gtc%2C length %3D 74;anticodon=(pos:924144..924146);gbkey=tRNA;gene=aspT;product=tRNA-Asp
AL123456.3	EMBL	exon	924110	924183	.	+	.	ID=exon-aspT-1;Parent=rna-aspT;Note=codon recognized: GAC%3B aspT%2C tRNA-Asp%2C anticodon gtc%2C length %3D 74;anticodon=(pos:924144..924146);gbkey=tRNA;gene=aspT;product=tRNA-Asp
AL123456.3	EMBL	gene	924213	924286	.	+	.	ID=gene-pheU;Name=pheU;gbkey=Gene;gene=pheU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	924213	924286	.	+	.	ID=rna-pheU;Parent=gene-pheU;Note=codon recognized: UUC%3B pheU%2C tRNA-Phe%2C anticodon gaa%2C length %3D 74;anticodon=(pos:924247..924249);gbkey=tRNA;gene=pheU;product=tRNA-Phe
AL123456.3	EMBL	exon	924213	924286	.	+	.	ID=exon-pheU-1;Parent=rna-pheU;Note=codon recognized: UUC%3B pheU%2C tRNA-Phe%2C anticodon gaa%2C length %3D 74;anticodon=(pos:924247..924249);gbkey=tRNA;gene=pheU;product=tRNA-Phe
AL123456.3	EMBL	gene	924951	925364	.	+	.	ID=gene-Rv0832;Name=PE_PGRS12;gbkey=Gene;gene=PE_PGRS12;gene_biotype=protein_coding;locus_tag=Rv0832
AL123456.3	EMBL	CDS	924951	925364	.	+	0	ID=cds-CCP43580.1;Parent=gene-Rv0832;Dbxref=EnsemblGenomes-Gn:Rv0832,EnsemblGenomes-Tr:CCP43580,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FV8,NCBI_GP:CCP43580.1;Name=CCP43580.1;Note=Rv0832%2C (MTV043.24)%2C len: 137 aa. PE_PGRS12%2C Member of the Mycobacterium tuberculosis PE family%2C possibly PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to many others e.g. MTCY1A11.25c|Z78020 (498 aa)%2CFASTA scores: opt: 529%2C E(): 5.2e-22%2C (61.8%25 identity in 136 aa overlap)%3B etc. Appears to have incurred frameshift as next ORF should be continuation%3B sequence has been checked but no error found.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS12;locus_tag=Rv0832;product=PE-PGRS family protein PE_PGRS12;protein_id=CCP43580.1;transl_table=11
AL123456.3	EMBL	gene	925361	927610	.	+	.	ID=gene-Rv0833;Name=PE_PGRS13;gbkey=Gene;gene=PE_PGRS13;gene_biotype=protein_coding;locus_tag=Rv0833
AL123456.3	EMBL	CDS	925361	927610	.	+	0	ID=cds-CCP43581.1;Parent=gene-Rv0833;Dbxref=EnsemblGenomes-Gn:Rv0833,EnsemblGenomes-Tr:CCP43581,UniProtKB/TrEMBL:Q79FV7,NCBI_GP:CCP43581.1;Name=CCP43581.1;Note=Rv0833%2C (MTV043.25)%2C len: 749 aa. PE_PGRS13%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C 2002)%2C but lacking N-terminal domain (present in preceding ORF)%2Cpossibly due to frameshift. Similar in part to many others e.g. MTCY28_25|Z95890 (914 aa)%2C FASTA scores: opt: 2726%2CE(): 0%2C (60.1%25 identity in 776 aa overlap)%3B etc.;gbkey=CDS;gene=PE_PGRS13;locus_tag=Rv0833;product=PE-PGRS family protein PE_PGRS13;protein_id=CCP43581.1;transl_table=11
AL123456.3	EMBL	gene	927837	930485	.	-	.	ID=gene-Rv0834c;Name=PE_PGRS14;gbkey=Gene;gene=PE_PGRS14;gene_biotype=protein_coding;locus_tag=Rv0834c
AL123456.3	EMBL	CDS	927837	930485	.	-	0	ID=cds-CCP43582.1;Parent=gene-Rv0834c;Dbxref=EnsemblGenomes-Gn:Rv0834c,EnsemblGenomes-Tr:CCP43582,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FV6,NCBI_GP:CCP43582.1;Name=CCP43582.1;Note=Rv0834c%2C (MTV043.26c)%2C len: 882 aa. PE_PGRS14%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002)%2Chighly similar to many others e.g. MTCY493_4|Z95844 (1329 aa)%2C FASTA scores: opt: 2577%2C E(): 0%2C (52.0%25 identity in 950 aa overlap)%3B etc. Thought to be differentially expressed within host cells (see Triccas et al.%2C 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS14;locus_tag=Rv0834c;product=PE-PGRS family protein PE_PGRS14;protein_id=CCP43582.1;transl_table=11
AL123456.3	EMBL	gene	930953	931597	.	+	.	ID=gene-Rv0835;Name=lpqQ;gbkey=Gene;gene=lpqQ;gene_biotype=protein_coding;locus_tag=Rv0835
AL123456.3	EMBL	CDS	930953	931597	.	+	0	ID=cds-CCP43583.1;Parent=gene-Rv0835;Dbxref=EnsemblGenomes-Gn:Rv0835,EnsemblGenomes-Tr:CCP43583,GOA:O53846,InterPro:IPR026954,UniProtKB/TrEMBL:O53846,NCBI_GP:CCP43583.1;Name=CCP43583.1;Note=Rv0835%2C (MTV043.27)%2C len: 214 aa. Possible lpqQ%2Clipoprotein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqQ;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0835;product=Possible lipoprotein LpqQ;protein_id=CCP43583.1;transl_table=11
AL123456.3	EMBL	gene	932279	932932	.	-	.	ID=gene-Rv0836c;Name=Rv0836c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0836c
AL123456.3	EMBL	CDS	932279	932932	.	-	0	ID=cds-CCP43584.1;Parent=gene-Rv0836c;Dbxref=EnsemblGenomes-Gn:Rv0836c,EnsemblGenomes-Tr:CCP43584,InterPro:IPR014513,UniProtKB/TrEMBL:O53848,NCBI_GP:CCP43584.1;Name=CCP43584.1;Note=Rv0836c%2C (MTV043.29c)%2C len: 217 aa (start uncertain). Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0836c;product=Hypothetical protein;protein_id=CCP43584.1;transl_table=11
AL123456.3	EMBL	gene	933003	934031	.	-	.	ID=gene-Rv0837c;Name=Rv0837c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0837c
AL123456.3	EMBL	CDS	933003	934031	.	-	0	ID=cds-CCP43585.1;Parent=gene-Rv0837c;Dbxref=EnsemblGenomes-Gn:Rv0837c,EnsemblGenomes-Tr:CCP43585,InterPro:IPR016600,InterPro:IPR019238,UniProtKB/TrEMBL:I6Y4Y1,NCBI_GP:CCP43585.1;Name=CCP43585.1;Note=Rv0837c%2C (MTV043.30c)%2C len: 342 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv0837c;product=Hypothetical protein;protein_id=CCP43585.1;transl_table=11
AL123456.3	EMBL	gene	934720	935490	.	+	.	ID=gene-Rv0838;Name=lpqR;gbkey=Gene;gene=lpqR;gene_biotype=protein_coding;locus_tag=Rv0838
AL123456.3	EMBL	CDS	934720	935490	.	+	0	ID=cds-CCP43586.1;Parent=gene-Rv0838;Dbxref=EnsemblGenomes-Gn:Rv0838,EnsemblGenomes-Tr:CCP43586,GOA:O53850,InterPro:IPR000755,InterPro:IPR009045,UniProtKB/TrEMBL:O53850,NCBI_GP:CCP43586.1;Name=CCP43586.1;Note=Rv0838%2C (MTV043.31)%2C len: 256 aa. Probable lpqR%2Cconserved lipoprotein. Similar (except in N-terminus) to hypothetical proteins and D-alanyl-D-alanine dipeptidases e.g. NP_416005.1|NC_000913 hypothetical protein from Escherichia coli strain K12 (193 aa)%3B NP_421076.1|NC_002696 D-alanyl-D-alanine dipeptidase from Caulobacter crescentus (212 aa)%3B Q06241|VANX_ENTFC D-alanyl-D-alanine dipeptidase from Enterococcus faecium (202 aa)%2C FASTA scores: opt: 198%2CE(): 1.9e-05%2C (28.1%25 identity in 199 aa overlap)%3B etc. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqR;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0838;product=Probable conserved lipoprotein LpqR;protein_id=CCP43586.1;transl_table=11
AL123456.3	EMBL	gene	935577	936389	.	+	.	ID=gene-Rv0839;Name=Rv0839;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0839
AL123456.3	EMBL	CDS	935577	936389	.	+	0	ID=cds-CCP43587.1;Parent=gene-Rv0839;Dbxref=EnsemblGenomes-Gn:Rv0839,EnsemblGenomes-Tr:CCP43587,InterPro:IPR025714,InterPro:IPR029063,UniProtKB/TrEMBL:I6X9X6,NCBI_GP:CCP43587.1;Name=CCP43587.1;Note=Rv0839%2C (MTV043.32)%2C len: 270 aa. Conserved hypothetical protein%2C similar to various hypothetical proteins or methyltransferases from yeast and bacteria e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hypothetical protein from Streptomyces coelicolor (273 aa)%2C FASTA scores: opt: 1102%2C E(): 0%2C (58.6%25 identity in 263 aa overlap)%3B T38024|Z98598|SPAC1B3.06c hypothetical protein from Schizosaccharomyces pombe (278 aa)%2C FASTA scores: opt: 562%2CE(): 1.9e-3%2C (36.4%25 identity in 269 aa overlap)%3B JC6531 avermectin B 5-O-methyltransferase from Streptomyces avermitilis (283 aa)%3B etc. Also similar to other Mycobacterium tuberculosis hypothetical proteins that may be methyltransferases e.g. Rv1523%2C Rv2952%2C Rv1405c%2C etc.;gbkey=CDS;locus_tag=Rv0839;product=Conserved hypothetical protein;protein_id=CCP43587.1;transl_table=11
AL123456.3	EMBL	gene	936457	937317	.	-	.	ID=gene-Rv0840c;Name=pip;gbkey=Gene;gene=pip;gene_biotype=protein_coding;locus_tag=Rv0840c
AL123456.3	EMBL	CDS	936457	937317	.	-	0	ID=cds-CCP43588.1;Parent=gene-Rv0840c;Dbxref=EnsemblGenomes-Gn:Rv0840c,EnsemblGenomes-Tr:CCP43588,GOA:I6Y8X0,InterPro:IPR002410,InterPro:IPR005945,InterPro:IPR029058,UniProtKB/TrEMBL:I6Y8X0,NCBI_GP:CCP43588.1;Name=CCP43588.1;Note=Rv0840c%2C (MTV043.33c)%2C len: 286 aa. Possible pip%2Cproline iminopeptidase%2C similar to many e.g. P46541|PIP_BACCO proline iminopeptidase from bacillus coagulans (288 aa)%2C FASTA scores: opt: 657%2C E(): 0%2C (37.6%25 identity in 282 aa overlap)%3B NP_386922.1|NC_003047 putative proline iminopeptidase protein from Sinorhizobium meliloti (296 aa)%3B etc. Belongs to peptidase family S33.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pip;locus_tag=Rv0840c;product=Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap);protein_id=CCP43588.1;transl_table=11
AL123456.3	EMBL	gene	937593	937835	.	+	.	ID=gene-Rv0841;Name=Rv0841;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0841
AL123456.3	EMBL	CDS	937593	937835	.	+	0	ID=cds-CCP43589.1;Parent=gene-Rv0841;Dbxref=EnsemblGenomes-Gn:Rv0841,EnsemblGenomes-Tr:CCP43589,GOA:I6WZK3,UniProtKB/TrEMBL:I6WZK3,NCBI_GP:CCP43589.1;Name=CCP43589.1;Note=Rv0841%2C len: 80 aa. Conserved transmembrane protein%2Chighly similar to C-terminus of next ORF Rv0842|O53854 putative membrane protein from Mycobacterium tuberculosis (442 aa)%2C FASTA scores: opt: 246%2C E(): 3.3e-10%2C (59.7%25 identity in 72 aa overlap). Replace previous Rv0841c.;gbkey=CDS;locus_tag=Rv0841;product=Probable conserved transmembrane protein;protein_id=CCP43589.1;transl_table=11
AL123456.3	EMBL	gene	938112	939404	.	+	.	ID=gene-Rv0842;Name=Rv0842;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0842
AL123456.3	EMBL	CDS	938112	939404	.	+	0	ID=cds-CCP43590.1;Parent=gene-Rv0842;Dbxref=EnsemblGenomes-Gn:Rv0842,EnsemblGenomes-Tr:CCP43590,GOA:O53854,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,UniProtKB/TrEMBL:O53854,NCBI_GP:CCP43590.1;Name=CCP43590.1;Note=Rv0842%2C (MT0864%2C MTV043.35)%2C len: 430 aa. Probable conserved integral membrane protein%2C showing similarity with other integral membrane proteins e.g. P28246|BCR_ECOLI bicyclomycin resistance protein from EScherichia coli (396 aa)%2C FASTA scores: opt: 216%2C E(): 5.4e-07%2C (23.7%25 identity in 376 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0842;product=Probable conserved integral membrane protein;protein_id=CCP43590.1;transl_table=11
AL123456.3	EMBL	gene	939388	940392	.	+	.	ID=gene-Rv0843;Name=Rv0843;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0843
AL123456.3	EMBL	CDS	939388	940392	.	+	0	ID=cds-CCP43591.1;Parent=gene-Rv0843;Dbxref=EnsemblGenomes-Gn:Rv0843,EnsemblGenomes-Tr:CCP43591,GOA:I6XWE5,InterPro:IPR001017,InterPro:IPR029061,UniProtKB/TrEMBL:I6XWE5,NCBI_GP:CCP43591.1;Name=CCP43591.1;Note=Rv0843%2C (MTV043.36)%2C len: 334 aa. Probable dehydrogenase%2C similar to various dehydrogenases e.g. Q46142|Q46142 TPP-dependent acetoin dehydrogenase (326 aa)%2CFASTA scores: opt: 500%2C E(): 2.4e-26%2C (32.3%25 identity in 300 aa overlap)%3B P51267|ODPA_PORPU pyruvate dehydrogenase E1 component from Porphyra purpurea (344 aa)%2C FASTA scores: opt: 451%2C E(): 4.7e-23%2C (29.6%25 identity in 311 aa overlap)%3B etc. Also similar to Rv2497c|pdhA pyruvate dehydrogenase E1 component from Mycobacterium tuberculosis (367 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0843;product=Probable dehydrogenase;protein_id=CCP43591.1;transl_table=11
AL123456.3	EMBL	gene	940456	941106	.	-	.	ID=gene-Rv0844c;Name=narL;gbkey=Gene;gene=narL;gene_biotype=protein_coding;locus_tag=Rv0844c
AL123456.3	EMBL	CDS	940456	941106	.	-	0	ID=cds-CCP43592.1;Parent=gene-Rv0844c;Dbxref=EnsemblGenomes-Gn:Rv0844c,EnsemblGenomes-Tr:CCP43592,GOA:P9WGM5,InterPro:IPR000792,InterPro:IPR001789,InterPro:IPR011006,InterPro:IPR011991,InterPro:IPR016032,PDB:3EUL,NCBI_GP:CCP43592.1;Name=CCP43592.1;Note=Rv0844c%2C (MTV043.37c)%2C len: 216 aa. Possible narL%2Cnitrate/nitrite response regulator protein%2C similar to many e.g. CAB44989.1|AJ131854 NarL protein from Pseudomonas stutzeri (218 aa)%3B CAA75536.1|Y15252 nitrate/nitrite regulatory protein from Pseudomonas aeruginosa (216 aa)%3B PCC6803|D64005|SYCSLRG_24 NarL protein from Synechocystis sp. (209 aa)%2C FASTA scores: opt: 438%2C E(): 1.5e-23%2C (34.6%25 identity in 208 aa overlap)%3B etc. Also similar to unidentified regulator e.g. CAB76009.1|AL157916 putative two-component system response regulator from Streptomyces coelicolor (224 aa)%3B etc. Contains probable helix-turn helix motif from aa 170-191 (Score 1124%2C +3.02 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narL;locus_tag=Rv0844c;product=Possible nitrate/nitrite response transcriptional regulatory protein NarL;protein_id=CCP43592.1;transl_table=11
AL123456.3	EMBL	gene	941190	942467	.	+	.	ID=gene-Rv0845;Name=Rv0845;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0845
AL123456.3	EMBL	CDS	941190	942467	.	+	0	ID=cds-CCP43593.1;Parent=gene-Rv0845;Dbxref=EnsemblGenomes-Gn:Rv0845,EnsemblGenomes-Tr:CCP43593,GOA:O53857,InterPro:IPR003594,InterPro:IPR005467,NCBI_GP:CCP43593.1;Name=CCP43593.1;Note=Rv0845%2C (MTV043.38)%2C len: 425 aa. Possible two-component sensor kinase%2C with its C-terminus similar to C-terminal part of others e.g. NP_294951.1|NC_001263 two-component sensor histidine kinase from Deinococcus radiodurans (469 aa)%3B CAC32293.1|AL583943 putative two component system histidine kinase from Streptomyces coelicolor (404 aa)%3B NP_464546.1|NC_003210 protein similar to two-component sensor histidine kinase from Listeria monocytogenes (352 aa)%3B BSUB0017_193|Z9912 two-component sensor kinase from Bacillus subtilis (360 aa)%2C FASTA scores: opt: 275%2C E(): 1.6e-11%2C (30.3%25 identity in 234 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0845;product=Possible two component sensor kinase;protein_id=CCP43593.1;transl_table=11
AL123456.3	EMBL	gene	942680	944194	.	-	.	ID=gene-Rv0846c;Name=Rv0846c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0846c
AL123456.3	EMBL	CDS	942680	944194	.	-	0	ID=cds-CCP43594.1;Parent=gene-Rv0846c;Dbxref=EnsemblGenomes-Gn:Rv0846c,EnsemblGenomes-Tr:CCP43594,GOA:I6WZK7,InterPro:IPR001117,InterPro:IPR002355,InterPro:IPR006311,InterPro:IPR008972,InterPro:IPR011706,InterPro:IPR011707,UniProtKB/TrEMBL:I6WZK7,NCBI_GP:CCP43594.1;Name=CCP43594.1;Note=Rv0846c%2C (MTV043.39c)%2C len: 504 aa. Probable oxidase%2C showing similarity with several oxidases%2C mainly L-ascorbate oxidases and copper resistance proteins a (precursors) e.g. P24792|ASO_CUCMA L-ascorbate oxidase precursor (ascorbase) from Cucurbita maxima (Pumpkin) (Winter squash) (579 aa)%2C FASTA scores: opt: 423%2C E(): 5.8e-18%2C (28.4%25 identity in 493 aa overlap)%3B AF010496|AF010496_32 potential multicopper oxidase from Rhodobacter capsulatus (491 aa)%2C FASTA scores: opt: 490%2CE(): 2.7e-22%2C (28.8%25 identity in 510 aa overlap)%3B 47452|PCOA_ECOLI copper resistance protein A precursor (belongs to the family of multicopper oxidases) from Escherichia coli strain K12 (605 aa)%3B etc. Contains PS00080 Multicopper oxidases signature 2 at C-terminus. Seems to belong to the family of multicopper oxidases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00080;locus_tag=Rv0846c;product=Probable oxidase;protein_id=CCP43594.1;transl_table=11
AL123456.3	EMBL	gene	944343	944735	.	+	.	ID=gene-Rv0847;Name=lpqS;gbkey=Gene;gene=lpqS;gene_biotype=protein_coding;locus_tag=Rv0847
AL123456.3	EMBL	CDS	944343	944735	.	+	0	ID=cds-CCP43595.1;Parent=gene-Rv0847;Dbxref=EnsemblGenomes-Gn:Rv0847,EnsemblGenomes-Tr:CCP43595,GOA:O53859,UniProtKB/TrEMBL:O53859,NCBI_GP:CCP43595.1;Name=CCP43595.1;Note=Rv0847%2C (MTV043.40)%2C len: 130 aa. Probable lpqS%2Clipoprotein. Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lpqS;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0847;product=Probable lipoprotein LpqS;protein_id=CCP43595.1;transl_table=11
AL123456.3	EMBL	gene	944938	946056	.	+	.	ID=gene-Rv0848;Name=cysK2;gbkey=Gene;gene=cysK2;gene_biotype=protein_coding;gene_synonym=cysM3;locus_tag=Rv0848
AL123456.3	EMBL	CDS	944938	946056	.	+	0	ID=cds-CCP43596.1;Parent=gene-Rv0848;Dbxref=EnsemblGenomes-Gn:Rv0848,EnsemblGenomes-Tr:CCP43596,GOA:Q79FV4,InterPro:IPR001926,NCBI_GP:CCP43596.1;Name=CCP43596.1;Note=Rv0848%2C (MTV043.41)%2C len: 372 aa. Possible cysK2%2Ccysteine synthase A%2C but could be also a cysteine synthase B cysM2-product%2C similar to many e.g. NP_109408.1|NC_002682 cysteine synthase from Mesorhizobium loti (357 aa)%3B Q44004|CYSM_ALCEU cysteine synthase from Alcaligenes eutrophus strain CH34 (Ralstonia eutropha) (339 aa)%2C FASTA scores: opt: 511%2C E(): 1.7e-25%2C (35.0%25 identity in 314 aa overlap)%3B etc. Belongs to the cysteine synthase/cystathionine beta-synthase family. Cofactor: pyridoxal phosphate. Note that previously known as cysM3.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysK2;locus_tag=Rv0848;product=Possible cysteine synthase a CysK2 (O-acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSASE);protein_id=CCP43596.1;transl_table=11
AL123456.3	EMBL	gene	946056	947315	.	+	.	ID=gene-Rv0849;Name=Rv0849;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0849
AL123456.3	EMBL	CDS	946056	947315	.	+	0	ID=cds-CCP43597.1;Parent=gene-Rv0849;Dbxref=EnsemblGenomes-Gn:Rv0849,EnsemblGenomes-Tr:CCP43597,GOA:P9WJX5,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP43597.1;Name=CCP43597.1;Note=Rv0849%2C (MTV043.42)%2C len: 419 aa. Probable conserved integral membrane transport protein%2C possibly member of major facilitator superfamily (MFS) involved in transport of drug%2C showing similarity with others e.g. T35055 probable transport system permease protein from Streptomyces coelicolor (436 aa)%3B NP_295031.1|NC_001263 major facilitator family protein from Deinococcus radiodurans (458 aa)%3B NP_455659.1|NC_003198 putative membrane transporter from Salmonella enterica subsp. enterica serovar Typhi (402 aa)%3B etc.;gbkey=CDS;locus_tag=Rv0849;product=Probable conserved integral membrane transport protein;protein_id=CCP43597.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	947311	947641	.	+	.	ID=id-AL123456.3:947311..947641;Note=IS1606'%2C len: 331 nt. Insertion sequence IS1606';gbkey=mobile_element;mobile_element_type=insertion sequence:IS1606'
AL123456.3	EMBL	gene	947312	947644	.	+	.	ID=gene-Rv0850;Name=Rv0850;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0850
AL123456.3	EMBL	CDS	947312	947644	.	+	0	ID=cds-CCP43598.1;Parent=gene-Rv0850;Dbxref=EnsemblGenomes-Gn:Rv0850,EnsemblGenomes-Tr:CCP43598,UniProtKB/TrEMBL:I6Y8X8,NCBI_GP:CCP43598.1;Name=CCP43598.1;Note=Rv0850%2C (MTV043.43)%2C len: 110 aa. Putative transposase (fragment)%2C similar in part to others e.g. Q45144|Q4514 transposable element IS31831 (436 aa)%2C FASTA scores: opt: 175%2C E(): 4.3e-05%2C (38.6%25 identity in 57 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv0850;product=Putative transposase (fragment);protein_id=CCP43598.1;transl_table=11
AL123456.3	EMBL	gene	947641	948468	.	-	.	ID=gene-Rv0851c;Name=Rv0851c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0851c
AL123456.3	EMBL	CDS	947641	948468	.	-	0	ID=cds-CCP43599.1;Parent=gene-Rv0851c;Dbxref=EnsemblGenomes-Gn:Rv0851c,EnsemblGenomes-Tr:CCP43599,GOA:O53863,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:O53863,NCBI_GP:CCP43599.1;Name=CCP43599.1;Note=Rv0851c%2C (MTV043.44c)%2C len: 275 aa. Probable short-chain dehydrogenase/reductase%2C similar to many e.g. Q01198|LIGD_PSEPA C alpha-dehydrogenase (SDR family) from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (305 aa)%3B D11473|PSELIG_1 C alpha-dehydrogenase from P. paucimobilis (305 aa)%2C FASTA scores: opt: 468%2C E(): 4.9e-23%2C (30.8%25 identity in 279 aa overlap)%3B NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa)%3B etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0851c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP43599.1;transl_table=11
AL123456.3	EMBL	gene	948559	949395	.	+	.	ID=gene-Rv0852;Name=fadD16;gbkey=Gene;gene=fadD16;gene_biotype=protein_coding;locus_tag=Rv0852
AL123456.3	EMBL	CDS	948559	949395	.	+	0	ID=cds-CCP43600.1;Parent=gene-Rv0852;Dbxref=EnsemblGenomes-Gn:Rv0852,EnsemblGenomes-Tr:CCP43600,GOA:I6Y4Z4,UniProtKB/TrEMBL:I6Y4Z4,NCBI_GP:CCP43600.1;Name=CCP43600.1;Note=Rv0852%2C (MTV043.45)%2C len: 278 aa. Possible fadD16%2Cfatty-acid-CoA synthetase%2C similar in part to various CoA ligases e.g. P18163|LCFB_RAT long-chain-fatty-acid--CoA ligase from Rattus norvegicus (Rat) (699 aa)%3B D49366|LEP4CCOALA_1 4-coumarate:CoA ligase from Lithospermum erythrorhizon (636 aa)%2C FASTA scores: opt: 134%2C E(): 0.15%2C (26.8%25 identity in 213 aa overlap)%3B orgp|L09229|HUMFACAL_1 long-chain acyl-coenzyme A from homo sapiens (human) (699 aa)%2C FASTA score: (50.0%25 identity in 40 aa overlap)%3B etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD16;inference=protein motif:PROSITE:PS00626;locus_tag=Rv0852;product=Possible fatty-acid-CoA ligase FadD16 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP43600.1;transl_table=11
AL123456.3	EMBL	gene	949436	951118	.	-	.	ID=gene-Rv0853c;Name=pdc;gbkey=Gene;gene=pdc;gene_biotype=protein_coding;locus_tag=Rv0853c
AL123456.3	EMBL	CDS	949436	951118	.	-	0	ID=cds-CCP43601.1;Parent=gene-Rv0853c;Dbxref=EnsemblGenomes-Gn:Rv0853c,EnsemblGenomes-Tr:CCP43601,GOA:P9WG37,InterPro:IPR000399,InterPro:IPR011766,InterPro:IPR012000,InterPro:IPR012001,InterPro:IPR012110,InterPro:IPR029035,InterPro:IPR029061,NCBI_GP:CCP43601.1;Name=CCP43601.1;Note=Rv0853c%2C (MTV043.46c)%2C len: 560 aa. Probable pdc%2Cpyruvate or indole-pyruvate decarboxylase%2C equivalent to NP_302424.1|NC_002677 pyruvate (or indolepyruvate) decarboxylase from Mycobacterium leprae (569 aa). Also highly similar to others e.g. AAB06571.1|L80006 indolepyruvate decarboxylase from Pantoea agglomerans (550 aa)%3B Q12629|DCPY_KLULA pyruvate decarboxylase from Kluyveromyces marxianus var. lactis (563 aa)%3B P71323 indolepyruvate decarboxylase from Enterobacter herbicola (550 aa)%2C FASTA scores: opt: 1642%2C E(): 0%2C (48.1%25 identity in 547 aa overlap)%3B P23234|DCIP_ENTCL indole-3-pyruvate decarboxylase (indolepyruvate decarboxylase) from Enterobacter cloacae (552 aa)%2C FASTA scores: opt: 1596%2CE(): 0%2C (46.8%25 identity in 551 aa overlap)%3B etc. Contains PS00187 Thiamine pyrophosphate enzymes signature and PS00017 ATP/GTP-binding site motif A (P-loop). Cofactor: thiamine pyrophosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pdc;inference=protein motif:PROSITE:PS00187;locus_tag=Rv0853c;product=Probable pyruvate or indole-3-pyruvate decarboxylase Pdc;protein_id=CCP43601.1;transl_table=11
AL123456.3	EMBL	gene	951183	951626	.	+	.	ID=gene-Rv0854;Name=Rv0854;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0854
AL123456.3	EMBL	CDS	951183	951626	.	+	0	ID=cds-CCP43602.1;Parent=gene-Rv0854;Dbxref=EnsemblGenomes-Gn:Rv0854,EnsemblGenomes-Tr:CCP43602,InterPro:IPR005031,InterPro:IPR023393,UniProtKB/TrEMBL:I6X9Y7,NCBI_GP:CCP43602.1;Name=CCP43602.1;Note=Rv0854%2C (MTV043.47)%2C len: 147 aa. Conserved protein%2Csimilar to several hypothetical protein from Mycobacterium leprae e.g. NP_301674.1|NC_002677 (144 aa)%3B NP_302683.1|NC_002677|Z95398|MLCL622.27c (156 aa)%2C FASTA scores: opt: 193%2C E(): 1.6e-06%2C (24.6%25 identity in 134 aa overlap)%3B NP_301218.1|NC_002677 (146 aa)%3B MTCI28.04|Z97050 (184 aa)%2C FASTA scores: opt: 171%2C E(): 5.8e-05%2C (21.5%25 identity in 135 aa overlap). Also similar to SC6G10.02c|T35511|AL049497|SC6G10_2 hypothetical protein from Streptomyces coelicolor (144 aa)%2C FASTA scores: opt: 344%2C E(): 6.1e- 17%2C (37.6%25 identity in 141 aa overlap). And similar to many proteins from Mycobacterium tuberculosis e.g. downstreams ORFs Rv0856 and Rv0857%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0854;product=Conserved protein;protein_id=CCP43602.1;transl_table=11
AL123456.3	EMBL	gene	951632	952711	.	+	.	ID=gene-Rv0855;Name=far;gbkey=Gene;gene=far;gene_biotype=protein_coding;locus_tag=Rv0855
AL123456.3	EMBL	CDS	951632	952711	.	+	0	ID=cds-CCP43603.1;Parent=gene-Rv0855;Dbxref=EnsemblGenomes-Gn:Rv0855,EnsemblGenomes-Tr:CCP43603,GOA:I6Y8Y0,InterPro:IPR003673,InterPro:IPR023606,UniProtKB/TrEMBL:I6Y8Y0,NCBI_GP:CCP43603.1;Name=CCP43603.1;Note=Rv0855%2C (MTV043.48)%2C len: 359 aa. Probable far%2Cfatty acid-CoA racemase%2C highly similar to CAB08122.1|Z94723 unknown protein from Mycobacterium leprae (253 aa) (C-terminus shorter). Also similar to many eukaryotic and bacteria racemases e.g. T35425 probable fatty acid CoA racemase from Streptomyces coelicolor (387 aa)%3B P70473|AMAC_RAT alpha-methylacyl-CoA racemase (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase) from Rattus norvegicus (Rat) (382 aa)%3B NP_103687.1|NC_002678 probable fatty acid Co-a racemase from Mesorhizobium loti (389 aa)%3B etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv1143|MTCI65.10|MCR from Mycobacterium tuberculosis (360 aa)%2C FASTA scores: opt: 1373%2C E(): 0%2C (56.8%25 identity in 359 aa overlap)%2C Rv1866|MTCY359.07 (C-terminal half) (778 aa)%2C Rv3272 (360 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=far;locus_tag=Rv0855;product=Probable fatty-acid-CoA racemase Far;protein_id=CCP43603.1;transl_table=11
AL123456.3	EMBL	gene	952825	953229	.	+	.	ID=gene-Rv0856;Name=Rv0856;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0856
AL123456.3	EMBL	CDS	952825	953229	.	+	0	ID=cds-CCP43604.1;Parent=gene-Rv0856;Dbxref=EnsemblGenomes-Gn:Rv0856,EnsemblGenomes-Tr:CCP43604,InterPro:IPR005031,UniProtKB/TrEMBL:O53868,NCBI_GP:CCP43604.1;Name=CCP43604.1;Note=Rv0856%2C (MTV043.49)%2C len: 134 aa. Conserved hypothetical protein%2C showing weak similarity with NP_301674.1| (NC_002677) conserved hypothetical protein from Mycobacterium leprae (144 aa)%3B and SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. neighbouring ORF downstream Rv0857 conserved hypothetical protein (126 aa)%2C FASTA scores: E(): 7.4e-27%2C (62.0%25 identity in 100 aa overlap)%3B neighbouring ORF Rv0854|MTV043_47 conserved hypothetical protein (147 aa)%2C FASTA scores: E(): 1.6e-15%2C (36.6%25 identity in 123 aa overlap)%2C MTCI28.04|Z97050|MTCI28_4 (184 aa)%2C FASTA scores: opt: 127%2C E(): 0.036%2C (26.0%25 identity in 127 aa overlap)%3B and MLCL622.27c|Z95398 (156 aa)%2C FASTA scores: opt: 123%2CE(): 0.06%2C (26.4%25 identity in 125 aa overlap).;gbkey=CDS;locus_tag=Rv0856;product=Conserved hypothetical protein;protein_id=CCP43604.1;transl_table=11
AL123456.3	EMBL	gene	953257	953730	.	+	.	ID=gene-Rv0857;Name=Rv0857;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0857
AL123456.3	EMBL	CDS	953257	953730	.	+	0	ID=cds-CCP43605.1;Parent=gene-Rv0857;Dbxref=EnsemblGenomes-Gn:Rv0857,EnsemblGenomes-Tr:CCP43605,InterPro:IPR019587,InterPro:IPR023393,UniProtKB/TrEMBL:I6Y4Z9,NCBI_GP:CCP43605.1;Name=CCP43605.1;Note=Rv0857%2C (MTV043.50)%2C len: 157 aa. Conserved hypothetical protein%2C showing weak similarity with Q9X7Y8|SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa)%2C FASTA scores: opt: 215%2CE(): 7.6e-08%2C (30.282%25 identity in 142 aa overlap). Also highly similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF Rv0856 (134 aa)%2C FASTA scores: opt: 566%2C E(): 2e-32%2C (58.15%25 identity in 129 aa overlap)%3B upstream ORF Rv0854 (147 aa)%2C FASTA scores: opt: 401%2C E(): 7.2e-21%2C (41.8%25 identity in 146 aa overlap)%3B MTCI28.04|Z97050 (184 aa)%2C FASTA scores: opt: 122%2C E(): 0.031%2C (29.4%25 identity in 85 aa overlap)%3B and MLCL622.27c|Z95398 (156 aa)%2C FASTA scores: opt: 114%2C E(): 0.1%2C (30.9%25 identity in 55 aa overlap). Length extended since first submission (+33 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0857;product=Conserved hypothetical protein;protein_id=CCP43605.1;transl_table=11
AL123456.3	EMBL	gene	953727	954920	.	-	.	ID=gene-Rv0858c;Name=dapC;gbkey=Gene;gene=dapC;gene_biotype=protein_coding;locus_tag=Rv0858c
AL123456.3	EMBL	CDS	953727	954920	.	-	0	ID=cds-CCP43606.1;Parent=gene-Rv0858c;Dbxref=EnsemblGenomes-Gn:Rv0858c,EnsemblGenomes-Tr:CCP43606,GOA:P9WPZ5,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,PDB:2O0R,NCBI_GP:CCP43606.1;Name=CCP43606.1;Note=Rv0858c%2C (MTV043.51c)%2C len: 397 aa. Probable dapC%2CN-succinyldiaminopimelate aminotransferase%2C highly similar to others from Eukaryota and bacteria%2C especially aspartate aminotransferases (transaminases)%2C e.g. NP_177890.1|NC_003070 putative aminotransferase from Arabidopsis thaliana (440 aa)%3B NP_419555.1|NC_002696 aminotransferase class I from Caulobacter crescentus (385 aa)%3B NP_415133.1|NC_000913|AE0001|ECAE000165_8 putative aminotransferase from Escherichia coli strain K12 (386 aa)%2CFASTA scores: opt: 830%2C E(): 0%2C (38.0%25 identity in 389 aa overlap)%3B X99521|TAX99521_1 aspartate aminotransferase from Thermus aquaticus (383 aa)%2C FASTA scores: opt: 702%2C E(): 0%2C(34.9%25 identity in 393 aa overlap)%3B etc. Also similar to other putative aminotransferases from Mycobacterium tuberculosis e.g. Rv2294%2C Rv3565%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dapC;locus_tag=Rv0858c;product=Probable N-succinyldiaminopimelate aminotransferase DapC (DAP-at);protein_id=CCP43606.1;transl_table=11
AL123456.3	EMBL	gene	955077	956288	.	+	.	ID=gene-Rv0859;Name=fadA;gbkey=Gene;gene=fadA;gene_biotype=protein_coding;locus_tag=Rv0859
AL123456.3	EMBL	CDS	955077	956288	.	+	0	ID=cds-CCP43607.1;Parent=gene-Rv0859;Dbxref=EnsemblGenomes-Gn:Rv0859,EnsemblGenomes-Tr:CCP43607,GOA:O53871,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020610,InterPro:IPR020613,InterPro:IPR020615,InterPro:IPR020616,InterPro:IPR020617,PDB:4B3H,PDB:4B3I,PDB:4B3J,NCBI_GP:CCP43607.1;Name=CCP43607.1;Note=Rv0859%2C (MTV043.52)%2C len: 403 aa. Possible fadA%2Cacyl-CoA thiolase%2C equivalent to NP_302423.1|NC_002677 putative beta-ketoadipyl CoA thiolase from Mycobacterium leprae (403 aa). Also highly similar to acyl/acetyl-CoA thiolases and beta-ketoadipyl CoA thiolases%2C e.g. T35428 probable acetyl CoA acetyltransferase (thiolase) from Streptomyces coelicolor (404 aa)%3B NP_250427.1|NC_002516 probable acyl-CoA thiolase from Pseudomonas aeruginosa (401 aa)%3B NP_106253.1|NC_002678 probable acyl-CoA thiolase from Mesorhizobium loti (402 aa)%3B NP_248919.1|NC_002516|PcaF beta-ketoadipyl CoA thiolase PcaF from Pseudomonas aeruginosa (401 aa)%3B etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature%2C PS00737 Thiolases signature 2 and PS00099 Thiolases active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadA;inference=protein motif:PROSITE:PS00737;locus_tag=Rv0859;product=Possible acyl-CoA thiolase FadA;protein_id=CCP43607.1;transl_table=11
AL123456.3	EMBL	gene	956293	958455	.	+	.	ID=gene-Rv0860;Name=fadB;gbkey=Gene;gene=fadB;gene_biotype=protein_coding;locus_tag=Rv0860
AL123456.3	EMBL	CDS	956293	958455	.	+	0	ID=cds-CCP43608.1;Parent=gene-Rv0860;Dbxref=EnsemblGenomes-Gn:Rv0860,EnsemblGenomes-Tr:CCP43608,GOA:O53872,InterPro:IPR001753,InterPro:IPR006108,InterPro:IPR006176,InterPro:IPR008927,InterPro:IPR013328,InterPro:IPR016040,InterPro:IPR029045,PDB:4B3H,PDB:4B3I,PDB:4B3J,UniProtKB/TrEMBL:O53872,NCBI_GP:CCP43608.1;Name=CCP43608.1;Note=Rv0860%2C (MTV043.53)%2C len: 720 aa. Probable fadB%2Cfatty oxidation protein%2C equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Also highly similar to others and various proteins involved in fatty acid metabolism%2C e.g. T35429 probable fatty oxidation protein from Streptomyces coelicolor (733 aa)%3B NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (714 aa)%3B NP_418895.1|NC_002696 fatty oxidation complex alpha subunit from Caulobacter crescentus (709 aa)%3B P40939|ECHA_HUMAN trifunctional enzyme alpha subunit [includes: long-chain enoyl-CoA hydratase %3B long chain 3-hydroxyacyl-CoA dehydrogenase ] from Homo sapiens (763 aa)%2C FASTA scores: opt: 1176%2C E(): 0%2C (32.4%25 identity in 722 aa overlap)%3B P21177|FADB_ECOLI fatty oxidation complex alpha subunit [includes: enoyl-CoA hydratase%3B delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase%3B 3-hydroxyacyl-CoA dehydrogenase%3B 3- hydroxybutyryl-CoA epimerase] from Escherichia coli strain K12 (729 aa)%2C FASTA scores: opt: 873%2C E(): 0%2C (33.6%25 identity in 693 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadB;locus_tag=Rv0860;product=Probable fatty oxidation protein FadB;protein_id=CCP43608.1;transl_table=11
AL123456.3	EMBL	gene	958523	960151	.	-	.	ID=gene-Rv0861c;Name=ercc3;gbkey=Gene;gene=ercc3;gene_biotype=protein_coding;locus_tag=Rv0861c
AL123456.3	EMBL	CDS	958523	960151	.	-	0	ID=cds-CCP43609.1;Parent=gene-Rv0861c;Dbxref=EnsemblGenomes-Gn:Rv0861c,EnsemblGenomes-Tr:CCP43609,GOA:O53873,InterPro:IPR001161,InterPro:IPR001650,InterPro:IPR006935,InterPro:IPR014001,InterPro:IPR027417,UniProtKB/TrEMBL:O53873,NCBI_GP:CCP43609.1;Name=CCP43609.1;Note=Rv0861c%2C (MTV043.54c)%2C len: 542 aa. Ercc3%2C DNA helicase (see citation below)%2C equivalent to NP_302420.1|NC_002677 probable DNA helicase from Mycobacterium leprae (549 aa). Also highly similar to others (shorter than several eukaryotic enzymes) e.g. NP_218820.1|NC_000919|AE001217|AE0 01217_6 putative DNA repair helicase from Treponema pallidum (606 aa)%2C FASTA scores: opt: 1275%2C E(): 0%2C (47.5%25 identity in 592 aa overlap)%3B Q00578|RA25_YEAST DNA repair helicase from Saccharomyces cerevisiae (843 aa)%2C FASTA scores: opt: 777%2CE(): 0%2C (30.4%25 identity in 605 aa overlap)%3B P49135|XPB_MOUSE DNA-repair protein complementing XP-B cells from Mus musculus (Mouse) (783 aa)%2C FASTA scores: opt: 761%2C E(): 0%2C (36.3%25 identity in 375 aa overlap)%3B etc. Seems to belong to the helicase family. Alternative nucleotide at position 958922 (C->a%3B A410A) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ercc3;locus_tag=Rv0861c;product=DNA helicase Ercc3;protein_id=CCP43609.1;transl_table=11
AL123456.3	EMBL	repeat_region	960173	960225	.	-	.	ID=id-AL123456.3:960173..960225;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	960226	960278	.	-	.	ID=id-AL123456.3:960226..960278;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	960279	960333	.	-	.	ID=id-AL123456.3:960279..960333;Note=55 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	960342	962612	.	-	.	ID=gene-Rv0862c;Name=Rv0862c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0862c
AL123456.3	EMBL	CDS	960342	962612	.	-	0	ID=cds-CCP43610.1;Parent=gene-Rv0862c;Dbxref=EnsemblGenomes-Gn:Rv0862c,EnsemblGenomes-Tr:CCP43610,GOA:O53874,UniProtKB/TrEMBL:O53874,NCBI_GP:CCP43610.1;Name=CCP43610.1;Note=Rv0862c%2C (MTV043.55c)%2C len: 756 aa. Conserved protein%2C equivalent to NP_302419.1|NC_002677 possible DNA-binding protein from Mycobacterium leprae (753 aa)%3B and highly similar (except in C-terminus) to MLCB57.01|Z99494|T45333 hypothetical protein from Mycobacterium leprae (>577 aa%2C truncated)%2C FASTA scores: opt: 3047%2C E(): 0%2C (78.9%25 identity in 578 aa overlap). Also similar in part to SCD12A.03c|AB93395.1|AL357524 hypothetical protein from Streptomyces coelicolor (867 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0862c;product=Conserved protein;protein_id=CCP43610.1;transl_table=11
AL123456.3	EMBL	gene	962599	962880	.	+	.	ID=gene-Rv0863;Name=Rv0863;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0863
AL123456.3	EMBL	CDS	962599	962880	.	+	0	ID=cds-CCP43611.1;Parent=gene-Rv0863;Dbxref=EnsemblGenomes-Gn:Rv0863,EnsemblGenomes-Tr:CCP43611,UniProtKB/TrEMBL:I6XWF9,NCBI_GP:CCP43611.1;Name=CCP43611.1;Note=Rv0863%2C (MTV043.56)%2C len: 93 aa. Conserved hypothetical protein%2C highly similar to NP_302418.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (74 aa). Also weakly similar in part to U82598|ECU82598_135 hypothetical protein from Escherichia coli%2C FASTA scores: (32.4%25 identity in 71 aa overlap)%3B and M74011|YEPYSCOP_8 hypothetical protein from Yersinia enterocolitica (165 aa)%2C FASTA scores: (38.6 identity in 57 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0863;product=Conserved hypothetical protein;protein_id=CCP43611.1;transl_table=11
AL123456.3	EMBL	gene	962890	963393	.	+	.	ID=gene-Rv0864;Name=moaC2;gbkey=Gene;gene=moaC2;gene_biotype=protein_coding;locus_tag=Rv0864
AL123456.3	EMBL	CDS	962890	963393	.	+	0	ID=cds-CCP43612.1;Parent=gene-Rv0864;Dbxref=EnsemblGenomes-Gn:Rv0864,EnsemblGenomes-Tr:CCP43612,GOA:P9WJR7,InterPro:IPR002820,InterPro:IPR023045,InterPro:IPR023046,PDB:4FDF,NCBI_GP:CCP43612.1;Name=CCP43612.1;Note=Rv0864%2C (MTV043.57)%2C len: 167 aa. Probable moaC2%2Cmolybdopterin cofactor biosynthesis protein%2C highly similar to others e.g. CAB59676.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (170 aa)%3B NP_418834.1|NC_002696 molybdenum cofactor biosynthesis protein C from Caulobacter crescentus (186 aa)%3B Y10817|ANY10817_3|T44852 molybdopterin co-factor synthesis protein moaC from Arthrobacter nicotinovorans plasmid pAO1 (169 aa)%2C FASTA scores: opt: 491%2C E(): 2.4e-29%2C (51.0%25 identity in 151 aa overlap)%3B etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 putative molybdenum cofactor biosynthesis protein C from Mycobacterium tuberculosis (170 aa)%2C FASTA scores: opt: 491%2C E(): 2.4e-29%2C (54.9%25 identity in 153 aa overlap)%3B and O53376|Rv3324c|MOAC3|MTV016.24c putative molybdenum cofactor biosynthesis protein C3 (177 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moaC2;locus_tag=Rv0864;product=Probable molybdenum cofactor biosynthesis protein C 2 MoaC2;protein_id=CCP43612.1;transl_table=11
AL123456.3	EMBL	gene	963390	963872	.	+	.	ID=gene-Rv0865;Name=mog;gbkey=Gene;gene=mog;gene_biotype=protein_coding;locus_tag=Rv0865
AL123456.3	EMBL	CDS	963390	963872	.	+	0	ID=cds-CCP43613.1;Parent=gene-Rv0865;Dbxref=EnsemblGenomes-Gn:Rv0865,EnsemblGenomes-Tr:CCP43613,GOA:I6Y8Y8,InterPro:IPR001453,InterPro:IPR020817,UniProtKB/TrEMBL:I6Y8Y8,NCBI_GP:CCP43613.1;Name=CCP43613.1;Note=Rv0865%2C (MTV043.58)%2C len: 160 aa. Probable mog%2Cmolybdopterin biosynthesis MOG protein%2C highly similar or similar to other molybdenum cofactor biosynthesis proteins e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa)%3B NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa)%3B CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa)%3B P44645|MOG_HAEIN|MOGA|HI0336 molybdopterin biosynthesis MOG protein from Haemophilus influenzae (197 aa)%2C FASTA scores: opt: 306%2C E(): 9e-13%2C(39.6%25 identity in 139 aa overlap)%3B P28694|MOG_ECOLI molybdopterin biosynthesis MOG protein from Escherichia coli (195 aa)%2C FASTA scores: opt: 265%2C E(): 3.6e-10%2C (34.2 identity in 146 aa overlap)%3B etc. Also highly similar to Rv0984|MTV044.12|MOAB2 possible pterin-4-alpha-carbinolamine dehydratase from Mycobacterium tuberculosis (181 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mog;locus_tag=Rv0865;product=Probable molybdopterin biosynthesis Mog protein;protein_id=CCP43613.1;transl_table=11
AL123456.3	EMBL	gene	963869	964294	.	+	.	ID=gene-Rv0866;Name=moaE2;gbkey=Gene;gene=moaE2;gene_biotype=protein_coding;locus_tag=Rv0866
AL123456.3	EMBL	CDS	963869	964294	.	+	0	ID=cds-CCP43614.1;Parent=gene-Rv0866;Dbxref=EnsemblGenomes-Gn:Rv0866,EnsemblGenomes-Tr:CCP43614,GOA:P9WJR1,InterPro:IPR003448,NCBI_GP:CCP43614.1;Name=CCP43614.1;Note=Rv0866%2C (MTV043.59)%2C len: 141 aa. Probable moaE2%2Cmolybdopterin converting factor E (molybdopterin converting factor (subunit 2))%2C similar to others e.g. Y10817|ANY10817_4|T44853 molybdopterin biosynthesis protein E chain from Arthrobacter nicotinovorans plasmid pAO1 (155 aa)%2C FASTA scores: opt: 460%2C E(): 3.5e-27%2C (49.3 identity in 146 aa overlap)%3B CAC01331.1|AL390968 moaE-like protein from Streptomyces coelicolor (152 aa)%3B NP_389313.1|NC_000964 molybdopterin converting factor (subunit 2) from Bacillus subtilis (157 aa)%3B etc. Also highly similar to Rv3119|MOAE1|Z95150|MTCY164_30 putative molybdenum cofactor biosynthesis protein E from Mycobacterium tuberculosis (147 aa)%2C FASTA scores: opt: 321%2C E(): 5.9e-17%2C (40.9%25 identity in 132 aa overlap)%3B and O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE fusion protein from Mycobacterium tuberculosis (221 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moaE2;locus_tag=Rv0866;product=Probable molybdenum cofactor biosynthesis protein E2 MoaE2 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor%2C subunit 2);protein_id=CCP43614.1;transl_table=11
AL123456.3	EMBL	gene	964312	965535	.	-	.	ID=gene-Rv0867c;Name=rpfA;gbkey=Gene;gene=rpfA;gene_biotype=protein_coding;locus_tag=Rv0867c
AL123456.3	EMBL	CDS	964312	965535	.	-	0	ID=cds-CCP43615.1;Parent=gene-Rv0867c;Dbxref=EnsemblGenomes-Gn:Rv0867c,EnsemblGenomes-Tr:CCP43615,GOA:P9WG31,InterPro:IPR010618,InterPro:IPR023346,NCBI_GP:CCP43615.1;Name=CCP43615.1;Note=Rv0867c%2C (MTV043.60c)%2C len: 407 aa. Possible rpfA%2Cresuscitation-promoting factor (see citation below). N-terminus highly similar to N-terminal part (1-125 aa) of Z99494|MLCB57_3|NP_302417.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (174 aa)%2CFASTA scores: opt: 785%2C E(): 1.8e-18%2C (63.0%25 identity in 200 aa overlap)%3B and highly similar to C-terminus of NP_301299.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (375 aa)%3B and middle part of NP_302360.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (157 aa). N-terminus also highly similar in part of three secreted proteins from Streptomyces coelicolor e.g. CAC09538.1|AL442120 putative secreted protein (244 aa). Regions highly similar to CAB76321.1|AL158060 putative membrane protein from Streptomyces coelicolor (121 aa)%3B and middle part of CAB09664.1|Z96935 rpf from Micrococcus luteus (220 aa). Also highly similar in part to four resuscitation-promoting factors from Mycobacterium tuberculosis: Rv2450 (172 aa)%2CRv1009 (362 aa)%2C Rv1884c (176 aa)%2C and Rv2389c (154 aa). Contains a probable secretory signal sequence in N-terminus. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpfA;locus_tag=Rv0867c;product=Possible resuscitation-promoting factor RpfA;protein_id=CCP43615.1;transl_table=11
AL123456.3	EMBL	gene	965983	966261	.	-	.	ID=gene-Rv0868c;Name=moaD2;gbkey=Gene;gene=moaD2;gene_biotype=protein_coding;locus_tag=Rv0868c
AL123456.3	EMBL	CDS	965983	966261	.	-	0	ID=cds-CCP43616.1;Parent=gene-Rv0868c;Dbxref=EnsemblGenomes-Gn:Rv0868c,EnsemblGenomes-Tr:CCP43616,InterPro:IPR003749,InterPro:IPR012675,InterPro:IPR016155,UniProtKB/TrEMBL:I6XWG2,NCBI_GP:CCP43616.1;Name=CCP43616.1;Note=Rv0868c%2C (MTV043.61c)%2C len: 92 aa. Probable moaD2%2Cmolybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1))%2C similar to CAB88494.1|AL353816 putative molybdopterin converting factor from Streptomyces coelicolor (84 aa)%3B and weakly similar to others MoaD proteins e.g. Z99111|BSUB0008_103 from Bacillus subtilis (77 aa)%2C FASTA scores: opt: 86%2C E(): 2.8%2C (22.9%25 identity in 83 aa overlap)%3B etc. Also some similarity with Rv3112|MOAD1|MTCY164.22 putative molybdenum cofactor biosynthesis protein D from Mycobacterium tuberculosis (83 aa)%2C FASTA scores: opt: 113%2C E(): 0.024%2C(31.3%25 identity in 83 aa overlap).;gbkey=CDS;gene=moaD2;locus_tag=Rv0868c;product=Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor%2C subunit 1);protein_id=CCP43616.1;transl_table=11
AL123456.3	EMBL	gene	966265	967347	.	-	.	ID=gene-Rv0869c;Name=moaA2;gbkey=Gene;gene=moaA2;gene_biotype=protein_coding;locus_tag=Rv0869c
AL123456.3	EMBL	CDS	966265	967347	.	-	0	ID=cds-CCP43617.1;Parent=gene-Rv0869c;Dbxref=EnsemblGenomes-Gn:Rv0869c,EnsemblGenomes-Tr:CCP43617,GOA:P9WJS1,InterPro:IPR000385,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR010505,InterPro:IPR013483,InterPro:IPR013785,NCBI_GP:CCP43617.1;Name=CCP43617.1;Note=Rv0869c%2C (MTV043.62c)%2C len: 360 aa. Probable moaA2%2Cmolybdenum cofactor biosynthesis protein%2C highly similar to others e.g. CAB59437.1|AL132644|SCI8_6 molybdenum cofactor biosynthesis protein A from Streptomyces coelicolor (341 aa)%2C FASTA scores: opt: 1336%2C E(): 0%2C (61.7%25 identity in 332 aa overlap)%3B S57490|X78980|ANMOAA_1 molybdopterin cofactor synthesis protein from Arthrobacter nicotinovorans (fragment) (374 aa)%2C FASTA scores: opt: 1059%2C E(): 0%2C(49.9%25 identity in 369 aa overlap)%3B Q44118|MOAA_ARTNI probable molybdopterin cofactor synthesis protein A from Arthrobacter nicotinovorans plasmid pAO1 (355 aa)%3B etc. Also similar to Rv3109|MTCY164.19|Z95150|MOAA1 putative molybdenum cofactor biosynthesis protein A from Mycobacterium tuberculosis (359 aa)%2C FASTA scores: opt: 657%2C E(): 0%2C (36.6%25 identity in 309 aa overlap). Belongs to the MoaA / NifB / PqqE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moaA2;locus_tag=Rv0869c;product=Probable molybdenum cofactor biosynthesis protein A2 MoaA2;protein_id=CCP43617.1;transl_table=11
AL123456.3	EMBL	gene	967344	967733	.	-	.	ID=gene-Rv0870c;Name=Rv0870c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0870c
AL123456.3	EMBL	CDS	967344	967733	.	-	0	ID=cds-CCP43618.1;Parent=gene-Rv0870c;Dbxref=EnsemblGenomes-Gn:Rv0870c,EnsemblGenomes-Tr:CCP43618,InterPro:IPR005185,UniProtKB/TrEMBL:I6Y8Z3,NCBI_GP:CCP43618.1;Name=CCP43618.1;Note=Rv0870c%2C (MTV043.63c)%2C len: 129 aa. Possible conserved integral membrane protein%2C highly similar to other membrane proteins: putative secreted proteins or hypothetical proteins e.g. CAC08263.1| AL392146 putative integral membrane protein from Streptomyces coelicolor (138 aa)%3B NP_233433.1|NC_002506 conserved hypothetical protein from Vibrio cholerae (143 aa)%3B NP_455572.1|NC_003198 putative membrane protein from Salmonella enterica subsp. enterica serovar Typhi (148 aa)%3B P37065|YCCF_ECOLI hypothetical 16.3 kDa protein from Escherichia coli (148 aa)%2C FASTA scores: opt: 183%2C E(): 1.9e-06%2C (36.6%25 identity in 134 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0870c;product=Possible conserved integral membrane protein;protein_id=CCP43618.1;transl_table=11
AL123456.3	EMBL	gene	967898	968305	.	+	.	ID=gene-Rv0871;Name=cspB;gbkey=Gene;gene=cspB;gene_biotype=protein_coding;locus_tag=Rv0871
AL123456.3	EMBL	CDS	967898	968305	.	+	0	ID=cds-CCP43619.1;Parent=gene-Rv0871;Dbxref=EnsemblGenomes-Gn:Rv0871,EnsemblGenomes-Tr:CCP43619,GOA:I6WZM9,InterPro:IPR002059,InterPro:IPR011129,InterPro:IPR012340,UniProtKB/TrEMBL:I6WZM9,NCBI_GP:CCP43619.1;Name=CCP43619.1;Note=Rv0871%2C (MTV043.64)%2C len: 135 aa. Probable cspB%2Ccold shock-like protein B%2C equivalent to Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from Mycobacterium leprae (136 aa)%2C FASTA scores: opt: 787%2C E(): 0%2C (86.0%25 identity in 136 aa overlap). Also highly similar (but often longer than) to others e.g. CAB93399.1|AL357524 cold shock protein B from Streptomyces coelicolor (127 aa)%3B Q45099|CSPD_BACCE cold shock-like protein CSPD from Bacillus cereus (66 aa)%3B Y101 81|LLCSPB_1 cold shock protein from Lactococcus lactis (66 aa)%2C FASTA scores: opt: 220%2C E(): 2.5e-07%2C (48.3%25 identity in 60 aa overlap)%3B etc. Seems to belong to the cold-shock domain (CSD) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cspB;locus_tag=Rv0871;product=Probable cold shock-like protein B CspB;protein_id=CCP43619.1;transl_table=11
AL123456.3	EMBL	gene	968424	970244	.	-	.	ID=gene-Rv0872c;Name=PE_PGRS15;gbkey=Gene;gene=PE_PGRS15;gene_biotype=protein_coding;locus_tag=Rv0872c
AL123456.3	EMBL	CDS	968424	970244	.	-	0	ID=cds-CCP43620.1;Parent=gene-Rv0872c;Dbxref=EnsemblGenomes-Gn:Rv0872c,EnsemblGenomes-Tr:CCP43620,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FV3,NCBI_GP:CCP43620.1;Name=CCP43620.1;Note=Rv0872c%2C (MTV043.65c)%2C len: 606 aa. PE_PGRS15%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002)%2Csimilar to many e.g. MTCY24A1.04c|Z95207 (615 aa)%2C FASTA scores: opt: 2636%2C E(): 0%2C (64.6%25 identity in 619 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS15;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0872c;product=PE-PGRS family protein PE_PGRS15;protein_id=CCP43620.1;transl_table=11
AL123456.3	EMBL	gene	970505	972457	.	+	.	ID=gene-Rv0873;Name=fadE10;gbkey=Gene;gene=fadE10;gene_biotype=protein_coding;locus_tag=Rv0873
AL123456.3	EMBL	CDS	970505	972457	.	+	0	ID=cds-CCP43621.1;Parent=gene-Rv0873;Dbxref=EnsemblGenomes-Gn:Rv0873,EnsemblGenomes-Tr:CCP43621,GOA:P9WQF7,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,NCBI_GP:CCP43621.1;Name=CCP43621.1;Note=Rv0873%2C (MTV043.66-MTCY31.01)%2C len: 650 aa. Probable fadE10%2C acyl-CoA dehydrogenase%2C highly similar to many e.g. CAB91129.1|AL355913 putative acyl CoA dehydrogenase from Streptomyces coelicolor (658 aa)%3B P50544|ACDV_MOUSE acyl-CoA dehydrogenase from Mus musculus (656 aa)%3B D30647|RATVLCAD_1 very-long-chain Acyl-CoA dehydrogenase from Rattus norvegicus (655 aa)%2C FASTA scores: opt: 675%2CE(): 0%2C (33.9%25 identity in 380 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE10;locus_tag=Rv0873;product=Probable acyl-CoA dehydrogenase FadE10;protein_id=CCP43621.1;transl_table=11
AL123456.3	EMBL	gene	972546	973706	.	-	.	ID=gene-Rv0874c;Name=Rv0874c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0874c
AL123456.3	EMBL	CDS	972546	973706	.	-	0	ID=cds-CCP43622.1;Parent=gene-Rv0874c;Dbxref=EnsemblGenomes-Gn:Rv0874c,EnsemblGenomes-Tr:CCP43622,GOA:P9WKR9,InterPro:IPR013702,InterPro:IPR016741,InterPro:IPR019494,NCBI_GP:CCP43622.1;Name=CCP43622.1;Note=Rv0874c%2C (MTCY31.02c)%2C len: 386 aa. Conserved hypothetical protein%2C highly similar in part to SPU62616_1 hypothetical protein from Synechococcus sp. (280 aa)%2C FASTA scores: E(): 6.3e-26%2C (35.2%25 identity in 264 aa overlap)%3B SYCSLLLH_102 from Synechocystis sp. (447 aa)%2C FASTA scores: E(): 1.1e-18%2C (29.5%25 identity in 400 aa overlap). Also highly similar to Rv0628c|MTCY20H10_9 from Mycobacterium tuberculosis (383 aa)%2C FASTA scores: E():0%2C (81.5%25 identity in 383 aa overlap).;gbkey=CDS;locus_tag=Rv0874c;product=Conserved hypothetical protein;protein_id=CCP43622.1;transl_table=11
AL123456.3	EMBL	gene	973806	974294	.	-	.	ID=gene-Rv0875c;Name=Rv0875c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0875c
AL123456.3	EMBL	CDS	973806	974294	.	-	0	ID=cds-CCP43623.1;Parent=gene-Rv0875c;Dbxref=EnsemblGenomes-Gn:Rv0875c,EnsemblGenomes-Tr:CCP43623,GOA:P9WKR7,InterPro:IPR024495,NCBI_GP:CCP43623.1;Name=CCP43623.1;Note=Rv0875c%2C (MTCY31.03c)%2C len: 162 aa. Possible conserved exported protein%2C equivalent to MLCB57_11|O33056 possible exported protein from Mycobacterium leprae (162 aa)%2C FASTA scores: opt: 789%2C E(): 0%2C (71.4%25 identity in 161 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0875c;product=Possible conserved exported protein;protein_id=CCP43623.1;transl_table=11
AL123456.3	EMBL	gene	974291	975937	.	-	.	ID=gene-Rv0876c;Name=Rv0876c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0876c
AL123456.3	EMBL	CDS	974291	975937	.	-	0	ID=cds-CCP43624.1;Parent=gene-Rv0876c;Dbxref=EnsemblGenomes-Gn:Rv0876c,EnsemblGenomes-Tr:CCP43624,GOA:P9WKR5,InterPro:IPR011701,InterPro:IPR016196,NCBI_GP:CCP43624.1;Name=CCP43624.1;Note=Rv0876c%2C (MTCY31.04c)%2C len: 548 aa. Possible conserved transmembrane protein%2C equivalent to MLCB57_12|O33057 possible membrane protein from Mycobacterium leprae (579 aa)%2C FASTA scores: opt: 2850%2CE(): 0%2C (81.0%25 identity in 568 aa overlap). Also highly similar (except in N-terminus) to CAB93403.1|AL357524 putative integral membrane protein from Streptomyces coelicolor (463 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0876c;product=Possible conserved transmembrane protein;protein_id=CCP43624.1;transl_table=11
AL123456.3	EMBL	gene	976075	976863	.	+	.	ID=gene-Rv0877;Name=Rv0877;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0877
AL123456.3	EMBL	CDS	976075	976863	.	+	0	ID=cds-CCP43625.1;Parent=gene-Rv0877;Dbxref=EnsemblGenomes-Gn:Rv0877,EnsemblGenomes-Tr:CCP43625,InterPro:IPR021391,NCBI_GP:CCP43625.1;Name=CCP43625.1;Note=Rv0877%2C (MTCY31.05)%2C len: 262 aa. Conserved hypothetical protein%2C equivalent to MLCB57_13|O33058 conserved hypothetical protein from Mycobacterium leprae (269 aa)%2C FASTA scores: E(): 0%2C (80.5%25 identity in 257 aa overlap). Also highly similar (except in C-terminus) to SCD12A.13|CAB93404.1|AL357524 hypothetical protein from Streptomyces coelicolor (308 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0877;product=Conserved hypothetical protein;protein_id=CCP43625.1;transl_table=11
AL123456.3	EMBL	gene	976872	978203	.	-	.	ID=gene-Rv0878c;Name=PPE13;gbkey=Gene;gene=PPE13;gene_biotype=protein_coding;locus_tag=Rv0878c
AL123456.3	EMBL	CDS	976872	978203	.	-	0	ID=cds-CCP43626.1;Parent=gene-Rv0878c;Dbxref=EnsemblGenomes-Gn:Rv0878c,EnsemblGenomes-Tr:CCP43626,GOA:P9WI35,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP43626.1;Name=CCP43626.1;Note=Rv0878c%2C (MTCY31.06c)%2C len: 443 aa. PPE13%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. P4261|YHS6_MYCTU (517 aa)%2C FASTA scores: opt: 1044%2C E(): 0%2C (47.4%25 identity in 397 aa overlap)%3B MTV014_3%2CMTCI65_2%2C MTCY98_24%2C MTCY3C7_23%2C MTCY48_17%2C MTV004_5%2CMTV004_3%2C etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=PPE13;locus_tag=Rv0878c;product=PPE family protein PPE13;protein_id=CCP43626.1;transl_table=11
AL123456.3	EMBL	gene	978481	978756	.	-	.	ID=gene-Rv0879c;Name=Rv0879c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0879c
AL123456.3	EMBL	CDS	978481	978756	.	-	0	ID=cds-CCP43627.1;Parent=gene-Rv0879c;Dbxref=EnsemblGenomes-Gn:Rv0879c,EnsemblGenomes-Tr:CCP43627,GOA:P9WKR1,InterPro:IPR019681,NCBI_GP:CCP43627.1;Name=CCP43627.1;Note=Rv0879c%2C (MTCY31.07c)%2C len: 91 aa. Possible conserved transmembrane protein%2C C-terminus highly similar to C-terminal part of MLCB57_14|O33059 conserved hypothetical protein from Mycobacterium leprae (91 aa)%2CFASTA scores: E(): 1.2e-25%2C (76.9%25 identity in 91 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0879c;product=Possible conserved transmembrane protein;protein_id=CCP43627.1;transl_table=11
AL123456.3	EMBL	gene	978934	979365	.	+	.	ID=gene-Rv0880;Name=Rv0880;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0880
AL123456.3	EMBL	CDS	978934	979365	.	+	0	ID=cds-CCP43628.1;Parent=gene-Rv0880;Dbxref=EnsemblGenomes-Gn:Rv0880,EnsemblGenomes-Tr:CCP43628,GOA:P9WMF1,InterPro:IPR000835,InterPro:IPR011991,InterPro:IPR023187,NCBI_GP:CCP43628.1;Name=CCP43628.1;Note=Rv0880%2C (MTCY31.08)%2C len: 143 aa. Possible transcriptional regulator%2C MarR family%2C equivalent to MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family protein from Mycobacterium leprae (143 aa)%2C FASTA scores: opt: 818%2C E(): 0%2C (89.5%25 identity in 143 aa overlap). Also similar to many others e.g. CAB93410.1|AL357524 putative marR-family protein from Streptomyces coelicolor (145 aa)%3B NP_251757.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (147 aa)%3B etc. Also similar to Rv2327 from Mycobacterium tuberculosis (163 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0880;product=Possible transcriptional regulatory protein (possibly MarR-family);protein_id=CCP43628.1;transl_table=11
AL123456.3	EMBL	gene	979362	980228	.	+	.	ID=gene-Rv0881;Name=Rv0881;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0881
AL123456.3	EMBL	CDS	979362	980228	.	+	0	ID=cds-CCP43629.1;Parent=gene-Rv0881;Dbxref=EnsemblGenomes-Gn:Rv0881,EnsemblGenomes-Tr:CCP43629,GOA:P9WFY3,InterPro:IPR001537,InterPro:IPR029026,InterPro:IPR029028,InterPro:IPR029064,NCBI_GP:CCP43629.1;Name=CCP43629.1;Note=Rv0881%2C (MTCY31.09)%2C len: 288 aa. Possible rRNA methyltransferase%2C highly similar to others and hypothetical proteins e.g. CAB76071.1|AL157953 putative rRNA methylase from Streptomyces coelicolor (272 aa)%3B NP_421117.1|NC_002696 spoU rRNA methylase family protein from Caulobacter crescentus (268 aa)%3B D90913_93|P74261 rRNA methylase from Synechocystis sp. (274 aa)%2C FASTA scores: E(): 1.1e-13%2C (26.3%25 identity in 278 aa overlap)%3B P18644|TSNR_STRCN rRNA methyltransferase from Streptomyces cyaneus (Streptomyces curacoi) (269 aa)%2C FASTA scores: E(): 3.7e-08%2C (23.9%25 identity in 268 aa overlap)%3B etc. Equivalent to AAK45146.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 46 aa.;gbkey=CDS;locus_tag=Rv0881;product=Possible rRNA methyltransferase (rRNA methylase);protein_id=CCP43629.1;transl_table=11
AL123456.3	EMBL	gene	980225	980509	.	+	.	ID=gene-Rv0882;Name=Rv0882;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0882
AL123456.3	EMBL	CDS	980225	980509	.	+	0	ID=cds-CCP43630.1;Parent=gene-Rv0882;Dbxref=EnsemblGenomes-Gn:Rv0882,EnsemblGenomes-Tr:CCP43630,GOA:P9WKQ9,InterPro:IPR024244,NCBI_GP:CCP43630.1;Name=CCP43630.1;Note=Rv0882%2C (MTCY31.10)%2C len: 94 aa. Probable transmembrane protein.;gbkey=CDS;locus_tag=Rv0882;product=Probable transmembrane protein;protein_id=CCP43630.1;transl_table=11
AL123456.3	EMBL	gene	980506	981267	.	-	.	ID=gene-Rv0883c;Name=Rv0883c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0883c
AL123456.3	EMBL	CDS	980506	981267	.	-	0	ID=cds-CCP43631.1;Parent=gene-Rv0883c;Dbxref=EnsemblGenomes-Gn:Rv0883c,EnsemblGenomes-Tr:CCP43631,GOA:P9WKQ7,InterPro:IPR021421,NCBI_GP:CCP43631.1;Name=CCP43631.1;Note=Rv0883c%2C (MTCY31.11c)%2C len: 253 aa. Conserved hypothetical protein%2C equivalent to O3306|MLCB57_16 conserved hypothetical protein from Mycobacterium leprae (251 aa)%2C FASTA scores: E(): 0%2C (79.4%25 identity in 253 aa overlap). Also highly similar to N_terminus of AL009204|SC9B10_22 hypothetical protein from Streptomyces coelicolor (352 aa)%2C FASTA scores: E(): 6.1e-20%2C (35.0%25 identity in 246 aa overlap).;gbkey=CDS;locus_tag=Rv0883c;product=Conserved hypothetical protein;protein_id=CCP43631.1;transl_table=11
AL123456.3	EMBL	gene	981424	982554	.	-	.	ID=gene-Rv0884c;Name=serC;gbkey=Gene;gene=serC;gene_biotype=protein_coding;locus_tag=Rv0884c
AL123456.3	EMBL	CDS	981424	982554	.	-	0	ID=cds-CCP43632.1;Parent=gene-Rv0884c;Dbxref=EnsemblGenomes-Gn:Rv0884c,EnsemblGenomes-Tr:CCP43632,GOA:P9WQ73,InterPro:IPR000192,InterPro:IPR006272,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR022278,PDB:2FYF,PDB:3VOM,NCBI_GP:CCP43632.1;Name=CCP43632.1;Note=Rv0884c%2C (MTCY31.12c)%2C len: 376 aa. Possible serC%2Cphosphoserine aminotransferase%2C equivalent to MLCB57_17 putative phosphoserine aminotransferase from Mycobacterium leprae (376 aa)%2C FASTA scores: E(): 0%2C (87.5 identity in 376 aa overlap). Also highly similar to CAC08322.1|AL392149 putative aminotransferase from Streptomyces coelicolor (363 aa)%3B and similar to other phosphoserine aminotransferases e.g. NP_386837.1|NC_003047 putative phosphoserine aminotransferase protein from Sinorhizobium meliloti (392 aa)%3B P52878|SERC_METBA phosphoserine aminotransferase from Methanosarcina barkeri (370 aa)%3B P10658|SERC_RABIT|RABEPIP_1 phosphoserine aminotransferase from Rabbit (370 aa)%2C FASTA scores: opt: 271%2C E(): 3.5e-11%2C(24.5%25 identity in 368 aa overlap)%3B etc. Belongs to class-V of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=serC;locus_tag=Rv0884c;product=Possible phosphoserine aminotransferase SerC (PSAT);protein_id=CCP43632.1;transl_table=11
AL123456.3	EMBL	gene	982762	983784	.	+	.	ID=gene-Rv0885;Name=Rv0885;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0885
AL123456.3	EMBL	CDS	982762	983784	.	+	0	ID=cds-CCP43633.1;Parent=gene-Rv0885;Dbxref=EnsemblGenomes-Gn:Rv0885,EnsemblGenomes-Tr:CCP43633,GOA:P9WKQ5,InterPro:IPR009078,InterPro:IPR025859,NCBI_GP:CCP43633.1;Name=CCP43633.1;Note=Rv0885%2C (MTCY31.13)%2C len: 340 aa. Conserved hypothetical protein%2C equivalent to O33063|MLCB57_18 possible transmembrane protein from Mycobacterium leprae (341 aa)%2C FASTA score: (83.9%25 identity in 341 aa overlap). Also similar except in C-terminus to T35630 probable membrane protein from Streptomyces coelicolor (312 aa).;gbkey=CDS;locus_tag=Rv0885;product=Conserved hypothetical protein;protein_id=CCP43633.1;transl_table=11
AL123456.3	EMBL	gene	983803	985530	.	+	.	ID=gene-Rv0886;Name=fprB;gbkey=Gene;gene=fprB;gene_biotype=protein_coding;locus_tag=Rv0886
AL123456.3	EMBL	CDS	983803	985530	.	+	0	ID=cds-CCP43634.1;Parent=gene-Rv0886;Dbxref=EnsemblGenomes-Gn:Rv0886,EnsemblGenomes-Tr:CCP43634,GOA:P9WJI1,InterPro:IPR001450,InterPro:IPR016040,InterPro:IPR017896,InterPro:IPR017900,InterPro:IPR021163,NCBI_GP:CCP43634.1;Name=CCP43634.1;Note=Rv0886%2C (MTCY31.14)%2C len: 575 aa. Probable fprB%2Cferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin oxidoreductase)%2C equivalent to O3306|MLCB57_19 ferredoxin/ferredoxin--NADP reductase from Mycobacterium leprae (555 aa)%2C FASTA scores: E(): 0%2C (76.6 identity in 560 aa overlap). Also highly similar or similar to others e.g. NP_294219.1|NC_001263 putative ferredoxin/ferredoxin--NADP reductase from Deinococcus radiodurans (479 aa) (N-terminus shorter)%3B P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from homo sapiens (497 aa)%2C FASTA scores: opt: 624%2C E(): 3e-30%2C(39.7%25 identity in 484 aa overlap)%3B P08165|ADRO_BOVIN NADPH:adrenodoxin oxidoreductase from Bos taurus (492 aa)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv3106%2C Rv3858c%2C etc. Contains PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fprB;inference=protein motif:PROSITE:PS00198;locus_tag=Rv0886;product=Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase);protein_id=CCP43634.1;transl_table=11
AL123456.3	EMBL	gene	985513	985971	.	-	.	ID=gene-Rv0887c;Name=Rv0887c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0887c
AL123456.3	EMBL	CDS	985513	985971	.	-	0	ID=cds-CCP43635.1;Parent=gene-Rv0887c;Dbxref=EnsemblGenomes-Gn:Rv0887c,EnsemblGenomes-Tr:CCP43635,InterPro:IPR025870,InterPro:IPR029068,NCBI_GP:CCP43635.1;Name=CCP43635.1;Note=Rv0887c%2C (MTCY31.15c)%2C len: 152 aa. Conserved hypothetical protein%2C highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa)%3B AL132644|SCI8_26 hypothetical protein from Streptomyces coelicolor (194 aa)%2CFASTA scores: opt: 220%2C E(): 1.5e-07%2C (33.6%25 identity in 131 aa overlap)%3B etc. Also shows weak similarity with transposases and related proteins.;gbkey=CDS;locus_tag=Rv0887c;product=Conserved hypothetical protein;protein_id=CCP43635.1;transl_table=11
AL123456.3	EMBL	gene	987233	988705	.	+	.	ID=gene-Rv0888;Name=Rv0888;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0888
AL123456.3	EMBL	CDS	987233	988705	.	+	0	ID=cds-CCP43636.1;Parent=gene-Rv0888;Dbxref=EnsemblGenomes-Gn:Rv0888,EnsemblGenomes-Tr:CCP43636,GOA:P9WKQ1,InterPro:IPR005135,NCBI_GP:CCP43636.1;Name=CCP43636.1;Note=Rv0888%2C (MTCY31.16)%2C len: 490 aa. Probable exported protein. Equivalent to AAK45157.1 from Mycobacterium tuberculosis strain CDC1551 (507 aa) but shorter 17 aa. Contains possible N-terminal signal sequence. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0888;product=Probable exported protein;protein_id=CCP43636.1;transl_table=11
AL123456.3	EMBL	gene	988740	989861	.	-	.	ID=gene-Rv0889c;Name=citA;gbkey=Gene;gene=citA;gene_biotype=protein_coding;gene_synonym=gltA;locus_tag=Rv0889c
AL123456.3	EMBL	CDS	988740	989861	.	-	0	ID=cds-CCP43637.1;Parent=gene-Rv0889c;Dbxref=EnsemblGenomes-Gn:Rv0889c,EnsemblGenomes-Tr:CCP43637,GOA:P9WPD3,InterPro:IPR002020,InterPro:IPR016141,InterPro:IPR016142,InterPro:IPR016143,InterPro:IPR019810,NCBI_GP:CCP43637.1;Name=CCP43637.1;Note=Rv0889c%2C (MTCY31.17c)%2C len: 373 aa. Probable citA (alternate gene name: gltA)%2C citrate synthase 2%2C highly similar to others e.g. CAB95899.1|AL359988 putative citrate synthase from Streptomyces coelicolor (387 aa)%3B P39119|CISY_BACSU citrate synthase II from Bacillus subtilis (366 aa)%2C FASTA scores: opt: 586%2C E(): 5.8e-30%2C(33.8%25 identity in 367 aa overlap)%3B etc. Also similar to Rv0896|MTCY31.24 from Mycobacterium tuberculosis (29.2%25 identity in 274 aa overlap) and Rv1131. Contains PS00480 Citrate synthase signature. Belongs to the citrate synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=citA;inference=protein motif:PROSITE:PS00480;locus_tag=Rv0889c;product=Probable citrate synthase II CitA;protein_id=CCP43637.1;transl_table=11
AL123456.3	EMBL	gene	989948	992596	.	-	.	ID=gene-Rv0890c;Name=Rv0890c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0890c
AL123456.3	EMBL	CDS	989948	992596	.	-	0	ID=cds-CCP43638.1;Parent=gene-Rv0890c;Dbxref=EnsemblGenomes-Gn:Rv0890c,EnsemblGenomes-Tr:CCP43638,GOA:P9WMG1,InterPro:IPR000792,InterPro:IPR011990,InterPro:IPR011991,InterPro:IPR016032,InterPro:IPR027417,NCBI_GP:CCP43638.1;Name=CCP43638.1;Note=Rv0890c%2C (MTCY31.18c)%2C len: 882 aa. Probable transcriptional regulatory protein%2C LuxR family%2C highly similar (but shorter 238 aa in N-terminus) to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar (generally in part) to others e.g. T50568 probable multi-domain regulatory protein from Streptomyces coelicolor (1334 aa)%3B P10957|NARL_ECOLI nitrate/nitrite response regulator protein from Escherichia coli (216 aa)%2CFASTA scores: opt: 193%2C E(): 6e-06%2C (37.4%25 identity in 99 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. MTCY02B10_22%2C MTV008_44%2CMTV036_21%2C and MTCY31_24. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00622 Bacterial regulatory proteins%2C luxR family signature%2C and probable helix-turn helix motif from aa 836 to 857 (Score 1559%2C +4.50 SD). Belongs to the LuxR/UhpA family of transcriptional regulators. Alternative nucleotide at position 990001 (G->C%3B P866A) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00622;locus_tag=Rv0890c;product=Probable transcriptional regulatory protein (probably LuxR-family);protein_id=CCP43638.1;transl_table=11
AL123456.3	EMBL	gene	992598	993455	.	-	.	ID=gene-Rv0891c;Name=Rv0891c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0891c
AL123456.3	EMBL	CDS	992598	993455	.	-	0	ID=cds-CCP43639.1;Parent=gene-Rv0891c;Dbxref=EnsemblGenomes-Gn:Rv0891c,EnsemblGenomes-Tr:CCP43639,GOA:P9WMV1,InterPro:IPR001054,InterPro:IPR029787,NCBI_GP:CCP43639.1;Name=CCP43639.1;Note=Rv0891c%2C (MTCY31.19c)%2C len: 285 aa. Possible transcriptional regulator%2C highly similar in N-terminus to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also highly similar to several Mycobacterium tuberculosis putative transcriptional regulators e.g. Q1102|MTCY02B10_22 probable transcriptional regulatory protein (1159 aa)%2C FASTA scores: opt: 702%2C E(): 8.3e-40%2C (50.6%25 identity in 247 aa overlap)%3B MTV036_21%3B MTV008_44%3B MTCY02B10_23. Also shows similarity with several adenylate cyclases and hydrolases from other organisms.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0891c;product=Possible transcriptional regulatory protein;protein_id=CCP43639.1;transl_table=11
AL123456.3	EMBL	gene	993853	995340	.	+	.	ID=gene-Rv0892;Name=Rv0892;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0892
AL123456.3	EMBL	CDS	993853	995340	.	+	0	ID=cds-CCP43640.1;Parent=gene-Rv0892;Dbxref=EnsemblGenomes-Gn:Rv0892,EnsemblGenomes-Tr:CCP43640,GOA:P9WNG1,NCBI_GP:CCP43640.1;Name=CCP43640.1;Note=Rv0892%2C (MTCY31.20)%2C len: 495 aa. Probable monooxygenase%2C highly similar to others e.g. NP_250787.1|NC_002516 probable flavin-binding monooxygenase from Pseudomonas aeruginosa (491 aa)%3B CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa)%3B P12015|CYMO_ACIS cyclohexanone monooxygenase from Acinetobacter sp. (542 aa)%2C FASTA scores: opt: 489%2C E(): 6.8e-26%2C (30.3%25 identity in 492 aa overlap)%3B etc. Also highly similar to Rv0565c%2C Rv3854c%2C Rv3083%2C etc from Mycobacterium tuberculosis. Has hydrophobic stretch at N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0892;product=Probable monooxygenase;protein_id=CCP43640.1;transl_table=11
AL123456.3	EMBL	gene	995318	996295	.	-	.	ID=gene-Rv0893c;Name=Rv0893c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0893c
AL123456.3	EMBL	CDS	995318	996295	.	-	0	ID=cds-CCP43641.1;Parent=gene-Rv0893c;Dbxref=EnsemblGenomes-Gn:Rv0893c,EnsemblGenomes-Tr:CCP43641,GOA:P9WFI1,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP43641.1;Name=CCP43641.1;Note=Rv0893c%2C (MTCY31.21c)%2C len: 325 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C belongs in family with P96823|Rv0146|MTCI5.20 from Mycobacterium tuberculosis (310 aa)%2C FASTA scores: opt: 784%2C E(): 0%2C (43.2%25 identity in 308 aa overlap)%3B Rv0726c%2C Rv0731c%2C Rv3399%2C etc. Also shows some similarity with others e.g. SC9B5.10|T35930 hypothetical protein from Streptomyces coelicolor (303 aa)%3B BSUB0008_141|Q45500 hypothetical 34.8 kDa protein from Bacillus subtilis (304 aa)%2C FASTA scores: E(): 0.00033%2C(26.8%25 identity in 168 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv0893c;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP43641.1;transl_table=11
AL123456.3	EMBL	gene	996524	997705	.	+	.	ID=gene-Rv0894;Name=Rv0894;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0894
AL123456.3	EMBL	CDS	996524	997705	.	+	0	ID=cds-CCP43642.1;Parent=gene-Rv0894;Dbxref=EnsemblGenomes-Gn:Rv0894,EnsemblGenomes-Tr:CCP43642,GOA:P9WKP9,InterPro:IPR027417,NCBI_GP:CCP43642.1;Name=CCP43642.1;Note=Rv0894%2C (MTCY31.22)%2C len: 393 aa. Possible regulatory protein%2C LuxR family%2C highly similar in part to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Also similar to others e.g. CAB95788.1|AL359949 putative multi-domain regulatory protein from Streptomyces coelicolor (780 aa)%3B NP_107293.1|NC_002678 transcriptional regulator from Mesorhizobium loti (903 aa)%3B etc. Also similar to other regulatory proteins from Mycobacterium tuberculosis e.g. Rv2488c|MTV008_44 (1137 aa)%2C FASTA score: (53.2%25 identity in 363 aa overlap)%3B Rv1358|MTCY02B10_22 (1159 aa)%2C FASTA score: (52.3%25 identity in 365 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0894;product=Possible transcriptional regulatory protein (possibly LuxR-family);protein_id=CCP43642.1;transl_table=11
AL123456.3	EMBL	gene	997782	999299	.	+	.	ID=gene-Rv0895;Name=Rv0895;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0895
AL123456.3	EMBL	CDS	997782	999299	.	+	0	ID=cds-CCP43643.1;Parent=gene-Rv0895;Dbxref=EnsemblGenomes-Gn:Rv0895,EnsemblGenomes-Tr:CCP43643,GOA:P9WKA3,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP43643.1;Name=CCP43643.1;Note=Rv0895%2C (MTCY31.23)%2C len: 505 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%3B member of family with: Rv3740c%2C Rv3734c%2C Rv1425%2C Rv1760%2C etc. Shows some similarity with NP_301898.1|NC_002677 conserved membrane protein from Mycobacterium leprae (491 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0895;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP43643.1;transl_table=11
AL123456.3	EMBL	gene	999472	1000767	.	+	.	ID=gene-Rv0896;Name=gltA2;gbkey=Gene;gene=gltA2;gene_biotype=protein_coding;locus_tag=Rv0896
AL123456.3	EMBL	CDS	999472	1000767	.	+	0	ID=cds-CCP43644.1;Parent=gene-Rv0896;Dbxref=EnsemblGenomes-Gn:Rv0896,EnsemblGenomes-Tr:CCP43644,GOA:P9WPD5,InterPro:IPR002020,InterPro:IPR010953,InterPro:IPR016141,InterPro:IPR016142,InterPro:IPR016143,InterPro:IPR019810,InterPro:IPR024176,NCBI_GP:CCP43644.1;Name=CCP43644.1;Note=Rv0896%2C (MTCY31.24)%2C len: 431 aa. Probable gltA2%2Ccitrate synthase 1%2C highly similar to O33066|NP_302405.1|NC_002677 citrate synthase 1 from Mycobacterium leprae (431 aa)%2C FASTA scores: E(): 0%2C (91.0 identity in 431 aa overlap)%3B and AAF04133.1|AF191033_1|AF191033 citrate synthase from Mycobacterium smegmatis (441 aa). Also highly similar to others e.g. AAF14286.1|AF181118_1|AF181118 citrate synthase from Streptomyces coelicolor (429 aa)%3B P42457|CISY_CORGL citrate synthase from Corynebacterium glutamicum (437 aa)%2CFASTA scores: opt: 1847%2C E(): 0%2C (63.0%25 identity in 433 aa overlap)%3B etc. Also similar to two other Mycobacterium tuberculosis citrate synthases%2C Rv0889|MTCY31.17c|citA (373 aa)%2C FASTA score: (29.2%25 identity in 274 aa overlap) and Rv1131|MTCY22G8.20|gltA1 (393 aa). Contains PS00480 Citrate synthase signature. Belongs to the citrate synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gltA2;inference=protein motif:PROSITE:PS00480;locus_tag=Rv0896;product=Probable citrate synthase I GltA2;protein_id=CCP43644.1;transl_table=11
AL123456.3	EMBL	gene	1000808	1002415	.	-	.	ID=gene-Rv0897c;Name=Rv0897c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0897c
AL123456.3	EMBL	CDS	1000808	1002415	.	-	0	ID=cds-CCP43645.1;Parent=gene-Rv0897c;Dbxref=EnsemblGenomes-Gn:Rv0897c,EnsemblGenomes-Tr:CCP43645,GOA:P9WKP7,NCBI_GP:CCP43645.1;Name=CCP43645.1;Note=Rv0897c%2C (MTCY31.25c)%2C len: 535 aa. Possible oxidoreductase%2C similar to various oxidoreductases from diverse organisms e.g. CAB94055.1|AL358672 putative oxidoreductase from Streptomyces coelicolor (540 aa)%3B NP_147877.1|NC_000854 phytoene dehydrogenase from Aeropyrum pernix (549 aa)%3B Q01671|CRTD_RHOSH methoxyneurosporene dehydrogenase from Rhodobacter sphaeroides (495 aa)%2C FASTA scores: opt: 139%2C E(): 2.6e-06%2C (23.8%25 identity in 538 aa overlap)%3B etc. Also similar to Rv1432%2C Rv2997%2C and Rv3829c from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0897c;product=Probable oxidoreductase;protein_id=CCP43645.1;transl_table=11
AL123456.3	EMBL	gene	1002441	1002704	.	-	.	ID=gene-Rv0898c;Name=Rv0898c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0898c
AL123456.3	EMBL	CDS	1002441	1002704	.	-	0	ID=cds-CCP43646.1;Parent=gene-Rv0898c;Dbxref=EnsemblGenomes-Gn:Rv0898c,EnsemblGenomes-Tr:CCP43646,InterPro:IPR020311,NCBI_GP:CCP43646.1;Name=CCP43646.1;Note=Rv0898c%2C (MTCY31.26c)%2C len: 87 aa. Conserved hypothetical protein%2C highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa)%2C FASTA score: (28.8%25 identity in 73 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0898c;product=Conserved hypothetical protein;protein_id=CCP43646.1;transl_table=11
AL123456.3	EMBL	gene	1002812	1003792	.	+	.	ID=gene-Rv0899;Name=ompA;gbkey=Gene;gene=ompA;gene_biotype=protein_coding;gene_synonym=ompATb;locus_tag=Rv0899
AL123456.3	EMBL	CDS	1002812	1003792	.	+	0	ID=cds-CCP43647.1;Parent=gene-Rv0899;Dbxref=EnsemblGenomes-Gn:Rv0899,EnsemblGenomes-Tr:CCP43647,GOA:P9WIU5,InterPro:IPR006664,InterPro:IPR006665,InterPro:IPR006690,InterPro:IPR007055,PDB:2KGS,PDB:2KGW,PDB:2KSM,PDB:2L26,PDB:2LBT,PDB:2LCA,NCBI_GP:CCP43647.1;Name=CCP43647.1;Note=Rv0899%2C (MTCY31.27)%2C len: 326 aa. OmpA%2C outer membrane protein A (See Senaratne et al.%2C 1998). C-terminal region similar to C-terminus of many members of the OmpA family of outer membrane proteins%2C e.g. NP_458280.1|NC_003198 putative outer membrane protein from Salmonella enterica subsp. enterica serovar Typhi (220)%3B NP_418008.1|NC_000913 putative outer membrane protein from Escherichia coli strain K12 (219 aa)%2C FASTA scores: opt: 296%2C E(): 2.2e-11%2C (45.3%25 identity in 117 aa overlap)%3B NP_231844.1|NC_002505 outer membrane protein OmpA from Vibrio cholerae (321 aa)%3B Q05146|OMPA_BORAV outer membrane protein A precursor from Bordetella avium (194 aa)%3B etc. A signal peptide sequence probably exists at the N-terminus. N-terminal domain is necessary and sufficient for membrane translocation (See Alahari et al.%2C 2007). Contains PS00044 Bacterial regulatory proteins%2C lysR family signature. Belongs to the OmpA family. Pore-forming activity is pH-dependent.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ompA;inference=protein motif:PROSITE:PS00044;locus_tag=Rv0899;product=Outer membrane protein A OmpA;protein_id=CCP43647.1;transl_table=11
AL123456.3	EMBL	gene	1003805	1003957	.	+	.	ID=gene-Rv0900;Name=Rv0900;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0900
AL123456.3	EMBL	CDS	1003805	1003957	.	+	0	ID=cds-CCP43648.1;Parent=gene-Rv0900;Dbxref=EnsemblGenomes-Gn:Rv0900,EnsemblGenomes-Tr:CCP43648,GOA:P9WJG7,NCBI_GP:CCP43648.1;Name=CCP43648.1;Note=Rv0900%2C (MTCY31.28)%2C len: 50 aa. Possible membrane protein%2C with hydrophobic domain from aa 4-26.;gbkey=CDS;locus_tag=Rv0900;product=Possible membrane protein;protein_id=CCP43648.1;transl_table=11
AL123456.3	EMBL	gene	1003957	1004484	.	+	.	ID=gene-Rv0901;Name=Rv0901;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0901
AL123456.3	EMBL	CDS	1003957	1004484	.	+	0	ID=cds-CCP43649.1;Parent=gene-Rv0901;Dbxref=EnsemblGenomes-Gn:Rv0901,EnsemblGenomes-Tr:CCP43649,GOA:P9WJG5,NCBI_GP:CCP43649.1;Name=CCP43649.1;Note=Rv0901%2C (MTCY31.29)%2C len: 175 aa. Possible conserved exported or membrane protein%2C with hydrophobic N-terminus at aa 7-25. Shows some similarity in C-terminus to O33070|Z99494|MLCB57.59 hypothetical protein from Mycobacterium leprae (113 aa)%2C FASTA scores: opt: 204%2C E(): 3.2e-12%2C (44.9%25 identity in 78 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0901;product=Possible conserved exported or membrane protein;protein_id=CCP43649.1;transl_table=11
AL123456.3	EMBL	gene	1004501	1005841	.	-	.	ID=gene-Rv0902c;Name=prrB;gbkey=Gene;gene=prrB;gene_biotype=protein_coding;locus_tag=Rv0902c
AL123456.3	EMBL	CDS	1004501	1005841	.	-	0	ID=cds-CCP43650.1;Parent=gene-Rv0902c;Dbxref=EnsemblGenomes-Gn:Rv0902c,EnsemblGenomes-Tr:CCP43650,GOA:P9WGK7,InterPro:IPR003594,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR009082,PDB:1YS3,PDB:1YSR,NCBI_GP:CCP43650.1;Name=CCP43650.1;Note=Rv0902c%2C (MTCY31.30c)%2C len: 446 aa. PrrB%2Ctwo-component sensor histidine kinase (see citations below)%2C transmembrane protein%2C equivalent to MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase from Mycobacterium leprae (446 aa)%3B and similar at C-termini to NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa). C-terminus also similar to the C-termini of many sensor-like histidine kinase proteins e.g. P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor protein from Escherichia coli strain K12 (457 aa)%2C FASTA scores: opt: 364%2C E(): 1.7e-15%2C (27.1%25 identity in 398 aa overlap)%3B CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (483 aa)%3B CAB82845.1|AJ277081 putative histidine kinase from Amycolatopsis mediterranei (472 aa)%3B etc. Also similar in part to Mycobacterium tuberculosis proteins Rv3764c (475 aa)%3B and Rv0982 (504 aa). Thought to be induced at phagocytosis (see Graham %26 Clark-Curtiss 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prrB;locus_tag=Rv0902c;product=Two component sensor histidine kinase PrrB;protein_id=CCP43650.1;transl_table=11
AL123456.3	EMBL	gene	1005852	1006562	.	-	.	ID=gene-Rv0903c;Name=prrA;gbkey=Gene;gene=prrA;gene_biotype=protein_coding;locus_tag=Rv0903c
AL123456.3	EMBL	CDS	1005852	1006562	.	-	0	ID=cds-CCP43651.1;Parent=gene-Rv0903c;Dbxref=EnsemblGenomes-Gn:Rv0903c,EnsemblGenomes-Tr:CCP43651,GOA:P9WGM1,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,PDB:1YS6,PDB:1YS7,NCBI_GP:CCP43651.1;Name=CCP43651.1;Note=Rv0903c%2C (MTCY31.31c)%2C len: 236 aa. PrrA%2Ctwo-component response regulator (see citations below)%2Cequivalent to Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component response regulator from Mycobacterium leprae (233 aa)%2C FASTA scores: opt: 1414%2C E(): 0%2C (95.7%25 identity in 233 aa overlap)%3B and similar to T45446 probable two-component response regulator from Mycobacterium leprae (253 aa). Also similar to many sensor-like histidine kinase proteins e.g. CAB88489.1|AL353816 putative two-component systen response regulator from Streptomyces coelicolor (248 aa)%3B AAG36759.1|AF119221_1 |AF119221 response regulator from Corynebacterium glutamicum (232 aa)%3B Q02540|COPR_PSESM transcriptional activator protein COPR from Pseudomonas syringae (pv. tomato) (227 aa)%2C FASTA scores: opt: 600%2CE(): 0%2C (44.4%25 identity in 225 aa overlap)%3B etc. Also similar to Rv0981 from Mycobacterium tuberculosis (230 aa)%2CRv3765c (234 aa)%2C phoP (247 aa)%2C etc. Thought to be induced at phagocytosis (see Graham %26 Clark-Curtiss 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prrA;locus_tag=Rv0903c;product=Two component response transcriptional regulatory protein PrrA;protein_id=CCP43651.1;transl_table=11
AL123456.3	EMBL	gene	1006693	1008180	.	-	.	ID=gene-Rv0904c;Name=accD3;gbkey=Gene;gene=accD3;gene_biotype=protein_coding;locus_tag=Rv0904c
AL123456.3	EMBL	CDS	1006693	1008180	.	-	0	ID=cds-CCP43652.1;Parent=gene-Rv0904c;Dbxref=EnsemblGenomes-Gn:Rv0904c,EnsemblGenomes-Tr:CCP43652,GOA:P9WQH9,InterPro:IPR000022,InterPro:IPR000438,InterPro:IPR011762,InterPro:IPR011763,InterPro:IPR029045,NCBI_GP:CCP43652.1;Name=CCP43652.1;Note=Rv0904c%2C (MTCY31.32c%2C MT0927)%2C len: 495 aa. Putative accD3%2C acetyl-CoA carboxylase carboxyl transferase%2C beta subunit (carboxyltransferase subunit of acetyl-CoA carboxylase)%2C highly similar in part to AAA63045.1|U15184 zinc finger protein from Mycobacterium leprae (201 aa). Also highly similar to others e.g. CAC42827.1|Y17592 putative carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum (491 aa)%3B CAB86110.1|AL163003 putative acetyl CoA carboxylase (alpha and beta subunits) from Streptomyces coelicolor (458 aa)%3B Q54776|ACCD_SYNP7 acetyl-coenzyme A carboxylase carboxyl transferase subunit beta from Synechococcus sp. (305 aa)%3B P12217|ACCD_MARPO acetyl-coenzyme A carboxylase carboxyl transferase subunit beta from Marchantia polymorpha (316 aa)%2C FASTA scores: opt: 519%2C E():1.6e-24%2C (40.2%25 identity in 219 aa overlap)%3B etc. Also similar to Rv3280%2C Rv2502c%2Cetc from Mycobacterium tuberculosis. Belongs to the ACCD/PCCB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accD3;locus_tag=Rv0904c;product=Putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) AccD3 (accase beta chain);protein_id=CCP43652.1;transl_table=11
AL123456.3	EMBL	gene	1008207	1008938	.	+	.	ID=gene-Rv0905;Name=echA6;gbkey=Gene;gene=echA6;gene_biotype=protein_coding;locus_tag=Rv0905
AL123456.3	EMBL	CDS	1008207	1008938	.	+	0	ID=cds-CCP43653.1;Parent=gene-Rv0905;Dbxref=EnsemblGenomes-Gn:Rv0905,EnsemblGenomes-Tr:CCP43653,GOA:P9WNP1,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,PDB:3HE2,NCBI_GP:CCP43653.1;Name=CCP43653.1;Note=Rv0905%2C (MTCY31.33)%2C len: 243 aa. Possible echA6%2Cenoyl-CoA hydratase%2C highly similar to ML15184|U15184 enoyl-CoA hydratase from Mycobacterium leprae (247 aa)%2CFASTA score: (85.8%25 identity in 247 aa overlap). Also similar to many e.g. NP_250320.1|NC_002516 probable enoyl-CoA hydratase/isomerase from Pseudomonas aeruginosa (261 aa)%3B NP_415911.1|NC_000913 putative enzyme from Escherichia coli strain K12 (255 aa)%3B P24162|ECHH_RHOCA|FADB1 enoyl-CoA hydratase homolog from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa)%2C FASTA scores: opt: 404%2C E():7.8e-21%2C (37.3%25 identity in 249 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA6;locus_tag=Rv0905;product=Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43653.1;transl_table=11
AL123456.3	EMBL	gene	1008944	1010062	.	+	.	ID=gene-Rv0906;Name=Rv0906;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0906
AL123456.3	EMBL	CDS	1008944	1010062	.	+	0	ID=cds-CCP43654.1;Parent=gene-Rv0906;Dbxref=EnsemblGenomes-Gn:Rv0906,EnsemblGenomes-Tr:CCP43654,GOA:P9WKP3,InterPro:IPR001279,InterPro:IPR024884,NCBI_GP:CCP43654.1;Name=CCP43654.1;Note=Rv0906%2C (MTCY31.34)%2C len: 372 aa. Conserved protein%2Chighly similar to others e.g. SC6A5.25|AL049485|T35416 hypothetical protein from Streptomyces coelicolor (370 aa)%2CFASTA scores: opt: 1125%2C E(): 0%2C (51.3%25 identity in 335 aa overlap)%3B NP_242955.1|NC_002570|BH2089 conserved protein from Bacillus halodurans (370 aa)%3B etc. Also shows some similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer membrane protein roma (fragment) from Klebsiella pneumoniae (132 aa)%2C FASTA scores: opt: 319%2C E(): 8.5e-14%2C (46.2%25 identity in 104 aa overlap)%3B NP_105215.1|NC_002678 hypothetical protein which contains similarity to outer membrane protein romA from Enterobacter cloacae (350 aa)%3B etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0906;product=Conserved protein;protein_id=CCP43654.1;transl_table=11
AL123456.3	EMBL	gene	1010136	1011734	.	+	.	ID=gene-Rv0907;Name=Rv0907;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0907
AL123456.3	EMBL	CDS	1010136	1011734	.	+	0	ID=cds-CCP43655.1;Parent=gene-Rv0907;Dbxref=EnsemblGenomes-Gn:Rv0907,EnsemblGenomes-Tr:CCP43655,GOA:O05900,InterPro:IPR001466,InterPro:IPR012338,InterPro:IPR021860,UniProtKB/TrEMBL:O05900,NCBI_GP:CCP43655.1;Name=CCP43655.1;Note=Rv0907%2C (MTCY21C12.01)%2C len: 532 aa. Conserved protein%2C possibly involved in cell wall biosynthesis: similar to many beta-lactamases%2C penicillin-binding proteins and hypothetical proteins e.g. NP_298910.1|NC_002488 beta-lactamase from Xylella fastidiosa (455 aa)%3B Q06317|PBP4_NOCLA penicillin-binding protein 4 (PBP-4) (381 aa)%2C FASTA scores: opt: 299%2C E(): 8.8e-05%2C (28.7%25 identity in 401 aa overlap)%3B etc. N-terminus highly similar to AAA63047.1|U15184 hypothetical protein from Mycobacterium leprae (58 aa). Related to other putative esterases and penicillin binding proteins in Mycobacterium tuberculosis e.g. Rv1730c|MTCY04C12.15c (517 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0907;product=Conserved protein;protein_id=CCP43655.1;transl_table=11
AL123456.3	EMBL	gene	1011731	1014124	.	+	.	ID=gene-Rv0908;Name=ctpE;gbkey=Gene;gene=ctpE;gene_biotype=protein_coding;locus_tag=Rv0908
AL123456.3	EMBL	CDS	1011731	1014124	.	+	0	ID=cds-CCP43656.1;Parent=gene-Rv0908;Dbxref=EnsemblGenomes-Gn:Rv0908,EnsemblGenomes-Tr:CCP43656,GOA:P9WPT1,InterPro:IPR001757,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023298,NCBI_GP:CCP43656.1;Name=CCP43656.1;Note=Rv0908%2C (MTCY21C12.02)%2C len: 797 aa. Probable ctpE%2Cmetal cation-transporting ATPase P-type%2C transmembrane protein%2C E1-E2 family%2C highly similar to many e.g. AB93406.1|AL357524 putative integral membrane ATPase from Streptomyces coelicolor (802 aa)%3B NP_346063.1|NC_003028 cation-transporting ATPase (E1-E2 family) from Streptococcus pneumoniae (778 aa)%3B P37278|ATCL_SYNP7|PACL cation-transporting atpase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (926 aa)%2C FASTA scores: opt: 257%2C E(): 4.8e-33%2C (27.7%25 identity in 905 aa overlap)%3B etc. Contains E1-E2 ATPases phosphorylation site (PS00154). Belongs to the cation transport ATPases family (E1-E2 ATPases).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpE;inference=protein motif:PROSITE:PS00154;locus_tag=Rv0908;product=Probable metal cation transporter ATPase P-type CtpE;protein_id=CCP43656.1;transl_table=11
AL123456.3	EMBL	gene	1014681	1014860	.	+	.	ID=gene-Rv0909;Name=Rv0909;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0909
AL123456.3	EMBL	CDS	1014681	1014860	.	+	0	ID=cds-CCP43657.1;Parent=gene-Rv0909;Dbxref=EnsemblGenomes-Gn:Rv0909,EnsemblGenomes-Tr:CCP43657,GOA:P9WJ07,InterPro:IPR028037,NCBI_GP:CCP43657.1;Name=CCP43657.1;Note=Rv0909%2C (MTCY21C12.03)%2C len: 59 aa. Conserved hypothetical protein%2C equivalent to NP_302399.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (56 aa). Also some similarity with AL022268|SC4H2_10c hypothetical protein from Streptomyces coelicolor (97 aa)%2CFASTA scores: opt: 106%2C E(): 0.13%2C (43.2%25 identity in 37 aa overlap).;gbkey=CDS;locus_tag=Rv0909;product=Conserved hypothetical protein;protein_id=CCP43657.1;transl_table=11
AL123456.3	EMBL	gene	1014866	1015300	.	+	.	ID=gene-Rv0910;Name=Rv0910;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0910
AL123456.3	EMBL	CDS	1014866	1015300	.	+	0	ID=cds-CCP43658.1;Parent=gene-Rv0910;Dbxref=EnsemblGenomes-Gn:Rv0910,EnsemblGenomes-Tr:CCP43658,GOA:P9WJ05,InterPro:IPR019587,InterPro:IPR023393,NCBI_GP:CCP43658.1;Name=CCP43658.1;Note=Rv0910%2C (MTCY21C12.04)%2C len: 144 aa. Conserved hypothetical protein%2C equivalent to NP_302398.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (181 aa)%2C FASTA scores: opt: 820%2C E(): 0%2C (83.9%25 identity in 143 aa overlap). Also similar to Rv1546|MTCY48.19c hypothetical protein from Mycobacterium tuberculosis (143 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv0910;product=Conserved hypothetical protein;protein_id=CCP43658.1;transl_table=11
AL123456.3	EMBL	gene	1015398	1016171	.	+	.	ID=gene-Rv0911;Name=Rv0911;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0911
AL123456.3	EMBL	CDS	1015398	1016171	.	+	0	ID=cds-CCP43659.1;Parent=gene-Rv0911;Dbxref=EnsemblGenomes-Gn:Rv0911,EnsemblGenomes-Tr:CCP43659,InterPro:IPR025870,InterPro:IPR029068,UniProtKB/TrEMBL:I6XA34,NCBI_GP:CCP43659.1;Name=CCP43659.1;Note=Rv0911%2C (MTCY21C12.05)%2C len: 257 aa. Conserved protein%2C showing similarity with hydroxylases and hypothetical proteins e.g. T35325 probable hydroxylase from Streptomyces coelicolor (265 aa)%3B Q54242 hypothetical protein from Streptomyces%2C FASTA scores: opt: 372%2C E(): 8.8e-18%2C (32.0%25 identity in 256 aa overlap)%3B AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV from Streptomyces peucetius (275 aa)%3B AAA63051.1|U15184 hypothetical protein from Mycobacterium leprae (94 aa)%3B etc. Also similar to Rv0577 hypothetical protein from Mycobacterium tuberculosis (261 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0911;product=Conserved protein;protein_id=CCP43659.1;transl_table=11
AL123456.3	EMBL	gene	1016236	1016685	.	+	.	ID=gene-Rv0912;Name=Rv0912;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0912
AL123456.3	EMBL	CDS	1016236	1016685	.	+	0	ID=cds-CCP43660.1;Parent=gene-Rv0912;Dbxref=EnsemblGenomes-Gn:Rv0912,EnsemblGenomes-Tr:CCP43660,GOA:O05904,UniProtKB/TrEMBL:O05904,NCBI_GP:CCP43660.1;Name=CCP43660.1;Note=Rv0912%2C (MTCY21C12.06)%2C len: 149 aa. Probable conserved transmembrane protein%2C equivalent to Q50121|NP_302397.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (144 aa)%2C FASTA scores: opt: 677%2CE(): 6.9e-38%2C (69.5%25 identity in 141 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv0912;product=Probable conserved transmembrane protein;protein_id=CCP43660.1;transl_table=11
AL123456.3	EMBL	gene	1017217	1018725	.	-	.	ID=gene-Rv0913c;Name=Rv0913c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0913c
AL123456.3	EMBL	CDS	1017217	1018725	.	-	0	ID=cds-CCP43661.1;Parent=gene-Rv0913c;Dbxref=EnsemblGenomes-Gn:Rv0913c,EnsemblGenomes-Tr:CCP43661,GOA:I6Y551,InterPro:IPR004294,UniProtKB/TrEMBL:I6Y551,NCBI_GP:CCP43661.1;Name=CCP43661.1;Note=Rv0913c%2C (MTCY21C12.07c)%2C len: 502 aa. Possible dioxygenase%2C showing similarity with others e.g. AAK38744.1|AY029525 carotenoid 9%2C10-9'%2C10' cleavage dioxygenase from Phaseolus vulgaris (543 aa)%3B CAB56138.1|AL117669 putative dioxygenase from Streptomyces coelicolor (503 aa)%3B AAK06796.1|AF324838_15|AF324838 putative dioxygenase SimC5 from Streptomyces antibioticus (456 aa)%3B Q53353|S65040 lignostilbene-alpha%2Cbeta-dioxygenase from Pseudomonas paucimobilis (485 aa)%2C FASTA scores: opt: 310%2C E(): 3.4e-20%2C (28.9%25 identity in 495 aa overlap)%3B etc. Also some similarity with Rv0654|MTCI376.22 probable dioxygenase from Mycobacterium tuberculosis (501 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0913c;product=Possible dioxygenase;protein_id=CCP43661.1;transl_table=11
AL123456.3	EMBL	gene	1018727	1019965	.	-	.	ID=gene-Rv0914c;Name=Rv0914c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0914c
AL123456.3	EMBL	CDS	1018727	1019965	.	-	0	ID=cds-CCP43662.1;Parent=gene-Rv0914c;Dbxref=EnsemblGenomes-Gn:Rv0914c,EnsemblGenomes-Tr:CCP43662,GOA:I6XWJ8,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020616,InterPro:IPR020617,UniProtKB/TrEMBL:I6XWJ8,NCBI_GP:CCP43662.1;Name=CCP43662.1;Note=Rv0914c%2C (MTCY21C12.08c)%2C len: 412 aa. Possible lipid carrier protein or keto acyl-CoA thiolase%2C highly similar to NP_421905.1|NC_002696 thiolase family protein from Caulobacter crescentus (407 aa)%3B and similar to others e.g. NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase from Mesorhizobium loti (392 aa)%3B NP_385796.1|NC_003047 putative 3-ketoacyl-CoA thiolase protein from Sinorhizobium meliloti (389 aa)%3B NP_275932.1|NC_000916 lipid-transfer protein (sterol or nonspecific) from Methanothermobacter thermautotrophicus (383 aa)%3B AB55378.1|AL117263 possible 3-ketoacyl-CoA thiolase from Leishmania major (441 aa)%2CFASTA scores: opt: 547%2C E(): 3.1e-26%2C (31.0%25 identity in 435 aa overlap)%3B etc. Also similar to Rv2790c%2C Rv1627c%2CRv0244%2C etc from Mycobacterium tuberculosis. Could belong to the thiolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0914c;product=Possible lipid carrier protein or keto acyl-CoA thiolase;protein_id=CCP43662.1;transl_table=11
AL123456.3	EMBL	gene	1020058	1021329	.	-	.	ID=gene-Rv0915c;Name=PPE14;gbkey=Gene;gene=PPE14;gene_biotype=protein_coding;gene_synonym=MTB41;locus_tag=Rv0915c
AL123456.3	EMBL	CDS	1020058	1021329	.	-	0	ID=cds-CCP43663.1;Parent=gene-Rv0915c;Dbxref=EnsemblGenomes-Gn:Rv0915c,EnsemblGenomes-Tr:CCP43663,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP43663.1;Name=CCP43663.1;Note=Rv0915c%2C (MTCY21C12.09c)%2C len: 423 aa. PPE14 (alternate gene name: MTB41). Member of the Mycobacterium tuberculosis PPE family (see citation below)%2C highly similar to many e.g. Rv1807 from Mycobacterium tuberculosis (403 aa)%2C FASTA scores: opt: 966%2C E(): 4.4e-30%2C (45.7%25 identity in 392 aa overlap)%3B etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.;gbkey=CDS;gene=PPE14;inference=protein motif:PROSITE:PS00626;locus_tag=Rv0915c;product=PPE family protein PPE14;protein_id=CCP43663.1;transl_table=11
AL123456.3	EMBL	gene	1021344	1021643	.	-	.	ID=gene-Rv0916c;Name=PE7;gbkey=Gene;gene=PE7;gene_biotype=protein_coding;gene_synonym=MTB10;locus_tag=Rv0916c
AL123456.3	EMBL	CDS	1021344	1021643	.	-	0	ID=cds-CCP43664.1;Parent=gene-Rv0916c;Dbxref=EnsemblGenomes-Gn:Rv0916c,EnsemblGenomes-Tr:CCP43664,InterPro:IPR000084,UniProtKB/TrEMBL:I6Y936,NCBI_GP:CCP43664.1;Name=CCP43664.1;Note=Rv0916c%2C (MTCY21C12.10c)%2C len: 99 aa. PE7 (alternate gene name: MTB10). Member of the Mycobacterium tuberculosis PE family (see citations below)%2C similar to many e.g. Rv1788 from Mycobacterium tuberculosis (99 aa)%2C FASTA scores: opt: 321%2C E(): 1.3e-11%2C (53.5%25 identity in 99 aa overlap)%3B etc.;gbkey=CDS;gene=PE7;locus_tag=Rv0916c;product=PE family protein PE7;protein_id=CCP43664.1;transl_table=11
AL123456.3	EMBL	gene	1022087	1023868	.	+	.	ID=gene-Rv0917;Name=betP;gbkey=Gene;gene=betP;gene_biotype=protein_coding;locus_tag=Rv0917
AL123456.3	EMBL	CDS	1022087	1023868	.	+	0	ID=cds-CCP43665.1;Parent=gene-Rv0917;Dbxref=EnsemblGenomes-Gn:Rv0917,EnsemblGenomes-Tr:CCP43665,GOA:P9WPR7,InterPro:IPR000060,InterPro:IPR018093,NCBI_GP:CCP43665.1;Name=CCP43665.1;Note=Rv0917%2C (MTCY21C12.11)%2C len: 593 aa. Possible betP%2Cglycine betaine transporter%2C integral membrane protein%2Chighly similar to many transporters%2C mainly glycine betaine transporters%2C e.g. P54582|BETP_CORGL glycine betaine transporter from Corynebacterium glutamicum (Brevibacterium flavum) (595 aa)%2C FASTA scores: opt: 1367%2C E(): 0%2C (42.7%25 identity in 504 aa overlap)%3B T35264 probable BccT family transporter from Streptomyces coelicolor (578 aa)%3B NP_243511.1|NC_002570 glycine betaine transporter from Bacillus halodurans (504 aa)%3B NP_439848.1|NC_000907 high-affinity choline transport protein (betT) from Haemophilus influenzae (669 aa)%3B etc. Seems to belong to the BCCT (TC 2.33) family of transporters.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=betP;locus_tag=Rv0917;product=Possible glycine betaine transport integral membrane protein BetP;protein_id=CCP43665.1;transl_table=11
AL123456.3	EMBL	gene	1024211	1024687	.	+	.	ID=gene-Rv0918;Name=Rv0918;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0918
AL123456.3	EMBL	CDS	1024211	1024687	.	+	0	ID=cds-CCP43666.1;Parent=gene-Rv0918;Dbxref=EnsemblGenomes-Gn:Rv0918,EnsemblGenomes-Tr:CCP43666,GOA:O05910,InterPro:IPR010985,InterPro:IPR014795,InterPro:IPR016547,UniProtKB/TrEMBL:O05910,NCBI_GP:CCP43666.1;Name=CCP43666.1;Note=Rv0918%2C (MTCY21C12.12)%2C len: 158 aa. Conserved protein%2C similar in part to Q50116 hypothetical protein from Mycobacterium leprae (44 aa)%2C FASTA scores: opt: 132%2CE(): 0.0055%2C (65.6%25 identity in 32 aa overlap). Also some similarity in C-terminus with other hypothetical proteins e.g. NP_289961.1|NC_002655 hypothetical protein from Escherichia coli strain O157:H7 (94 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0918;product=Conserved protein;protein_id=CCP43666.1;transl_table=11
AL123456.3	EMBL	gene	1024684	1025184	.	+	.	ID=gene-Rv0919;Name=Rv0919;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0919
AL123456.3	EMBL	CDS	1024684	1025184	.	+	0	ID=cds-CCP43667.1;Parent=gene-Rv0919;Dbxref=EnsemblGenomes-Gn:Rv0919,EnsemblGenomes-Tr:CCP43667,GOA:I6XA42,InterPro:IPR000182,InterPro:IPR016181,UniProtKB/TrEMBL:I6XA42,NCBI_GP:CCP43667.1;Name=CCP43667.1;Note=Rv0919%2C (MTCY21C12.13)%2C len: 166 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Some similarity to Q50115 hypothetical protein from Mycobacterium leprae (90 aa)%2C FASTA scores: opt: 243%2C E(): 5.3e-11%2C (56.5%25 identity in 85 aa overlap). Alternative nucleotide at position 1025106 (T->C%3B F141F) has been observed.;gbkey=CDS;locus_tag=Rv0919;product=GCN5-related N-acetyltransferase;protein_id=CCP43667.1;transl_table=11
AL123456.3	EMBL	gene	1025321	1025393	.	-	.	ID=gene-argT;Name=argT;gbkey=Gene;gene=argT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1025321	1025393	.	-	.	ID=rna-argT;Parent=gene-argT;Note=codon recognized: AGG%3B argT%2C tRNA-Arg%2C anticodon cct%2C length %3D 73;anticodon=(pos:complement(1025358..1025360));gbkey=tRNA;gene=argT;product=tRNA-Arg
AL123456.3	EMBL	exon	1025321	1025393	.	-	.	ID=exon-argT-1;Parent=rna-argT;Note=codon recognized: AGG%3B argT%2C tRNA-Arg%2C anticodon cct%2C length %3D 73;anticodon=(pos:complement(1025358..1025360));gbkey=tRNA;gene=argT;product=tRNA-Arg
AL123456.3	EMBL	mobile_genetic_element	1025458	1026893	.	-	.	ID=id-AL123456.3:1025458..1026893;Note=IS1554%2C len: 1436 nt. Putative Insertion sequence element bounded by 15 bp inverted repeats.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1554
AL123456.3	EMBL	repeat_region	1025458	1025472	.	+	.	ID=id-AL123456.3:1025458..1025472;Note=15 bp inverted repeat%2C ATTCGGTGTAAGTGG%2C at the left end of IS1554 element;gbkey=repeat_region
AL123456.3	EMBL	gene	1025497	1026816	.	-	.	ID=gene-Rv0920c;Name=Rv0920c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0920c
AL123456.3	EMBL	CDS	1025497	1026816	.	-	0	ID=cds-CCP43668.1;Parent=gene-Rv0920c;Dbxref=EnsemblGenomes-Gn:Rv0920c,EnsemblGenomes-Tr:CCP43668,GOA:I6Y941,InterPro:IPR001207,UniProtKB/TrEMBL:I6Y941,NCBI_GP:CCP43668.1;Name=CCP43668.1;Note=Rv0920c%2C (MTCY21C12.14c)%2C len: 439 aa. Probable transposase for IS1554%2C highly similar to others e.g. MTCY441.35|Q45111 transposase from Mycobacterium tuberculosis (419 aa)%2C FASTA scores: opt: 1113%2C E(): 0%2C(43.9%25 identity in 378 aa overlap)%3B etc. Contains transposases mutator family signature (PS01007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01007;locus_tag=Rv0920c;product=Probable transposase;protein_id=CCP43668.1;transl_table=11
AL123456.3	EMBL	repeat_region	1026879	1026893	.	-	.	ID=id-AL123456.3:1026879..1026893;Note=15 bp inverted repeat%2C ATTCGGTGTAAGTGG%2C at the right end of IS1554 element;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	1027061	1029360	.	+	.	ID=id-AL123456.3:1027061..1029360;Note=IS1535%2C len: 2300 nt. Putative Insertion sequence element bounded by 16 bp inverted repeats.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1535
AL123456.3	EMBL	repeat_region	1027061	1027076	.	+	.	ID=id-AL123456.3:1027061..1027076;Note=16 bp inverted repeat%2C TTGAGTGTGTTTTAGT%2C at the left end of IS element IS1535;gbkey=repeat_region
AL123456.3	EMBL	gene	1027104	1027685	.	+	.	ID=gene-Rv0921;Name=Rv0921;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0921
AL123456.3	EMBL	CDS	1027104	1027685	.	+	0	ID=cds-CCP43669.1;Parent=gene-Rv0921;Dbxref=EnsemblGenomes-Gn:Rv0921,EnsemblGenomes-Tr:CCP43669,GOA:I6WZS4,InterPro:IPR006119,UniProtKB/TrEMBL:I6WZS4,NCBI_GP:CCP43669.1;Name=CCP43669.1;Note=Rv0921%2C (MTCY21C12.15)%2C len: 193 aa. Possible resolvase for IS1535%2C highly similar to many bacterial resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from Mycobacterium tuberculosis (295 aa)%2C FASTA scores: opt: 537%2C E(): 5.7e-29%2C (51.8%25 identity in 166 aa overlap). Presents an helix turn helix motif.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0921;product=Possible resolvase;protein_id=CCP43669.1;transl_table=11
AL123456.3	EMBL	gene	1027685	1029337	.	+	.	ID=gene-Rv0922;Name=Rv0922;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0922
AL123456.3	EMBL	CDS	1027685	1029337	.	+	0	ID=cds-CCP43670.1;Parent=gene-Rv0922;Dbxref=EnsemblGenomes-Gn:Rv0922,EnsemblGenomes-Tr:CCP43670,InterPro:IPR001959,UniProtKB/TrEMBL:I6Y560,NCBI_GP:CCP43670.1;Name=CCP43670.1;Note=Rv0922%2C (MTCY21C12.16)%2C len: 550 aa. Possible transposase for IS1535%2C similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa)%2C FASTA scores: opt 939%2C E(): 0%2C(40.6%25 identity in 465 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0922;product=Possible transposase;protein_id=CCP43670.1;transl_table=11
AL123456.3	EMBL	repeat_region	1029345	1029360	.	-	.	ID=id-AL123456.3:1029345..1029360;Note=16 bp inverted repeat%2C TTGAGTGTGTTTTAGT%2C at the right end of IS element IS1535;gbkey=repeat_region
AL123456.3	EMBL	gene	1029513	1030577	.	-	.	ID=gene-Rv0923c;Name=Rv0923c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0923c
AL123456.3	EMBL	CDS	1029513	1030577	.	-	0	ID=cds-CCP43671.1;Parent=gene-Rv0923c;Dbxref=EnsemblGenomes-Gn:Rv0923c,EnsemblGenomes-Tr:CCP43671,GOA:I6XWK6,InterPro:IPR008585,InterPro:IPR013024,InterPro:IPR017939,UniProtKB/TrEMBL:I6XWK6,NCBI_GP:CCP43671.1;Name=CCP43671.1;Note=Rv0923c%2C (MTCY21C12.17c)%2C len: 354 aa. Conserved hypothetical protein%2C showing similarity with C-terminal part of AF034138|AF034138_7|yjoB hypothetical protein from Bacillus subtilis (200 aa)%2C FASTA scores: opt: 193%2C E(): 4.2e-05%2C (32.3%25 identity in 167 aa overlap).;gbkey=CDS;locus_tag=Rv0923c;product=Conserved hypothetical protein;protein_id=CCP43671.1;transl_table=11
AL123456.3	EMBL	gene	1030578	1031864	.	-	.	ID=gene-Rv0924c;Name=mntH;gbkey=Gene;gene=mntH;gene_biotype=protein_coding;gene_synonym=Mramp,Nramp;locus_tag=Rv0924c
AL123456.3	EMBL	CDS	1030578	1031864	.	-	0	ID=cds-CCP43672.1;Parent=gene-Rv0924c;Dbxref=EnsemblGenomes-Gn:Rv0924c,EnsemblGenomes-Tr:CCP43672,GOA:P9WIZ5,InterPro:IPR001046,NCBI_GP:CCP43672.1;Name=CCP43672.1;Note=Rv0924c%2C (MTCY21C12.18c)%2C len: 428 aa. MntH (alternative gene name: Nramp%2C Mramp)%2C H+-dependent divalent cation-transport integral membrane protein (see citations below)%2C equivalent to O69443|MNTH_MYCBO probable manganese transport protein MNTH (BRAMP) from Mycobacterium bovis (415 aa)%3B and NP_302396.1|NC_002677 probable manganese transport protein from Mycobacterium leprae (426 aa). Also similar (but longer 51 aa in N-terminus) to AAA63075.1|U15184 SMF2 protein from Mycobacterium leprae (377 aa)%2C FASTA scores: opt: 1780%2C E(): 0%2C (74.5%25 identity in 376 aa overlap). Also similar to many orthologues of the eukaryotic Nramp (natural resistance-associated macrophage protein)%2C also known as mntH%2C e.g. NP_456951.1|NC_003198 manganese transport protein MntH from Salmonella enterica subsp. enterica serovar Typhi (413 aa)%3B etc. Belongs to the NRAMP family.;gbkey=CDS;gene=mntH;locus_tag=Rv0924c;product=Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP);protein_id=CCP43672.1;transl_table=11
AL123456.3	EMBL	gene	1031896	1032633	.	-	.	ID=gene-Rv0925c;Name=Rv0925c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0925c
AL123456.3	EMBL	CDS	1031896	1032633	.	-	0	ID=cds-CCP43673.1;Parent=gene-Rv0925c;Dbxref=EnsemblGenomes-Gn:Rv0925c,EnsemblGenomes-Tr:CCP43673,GOA:I6Y946,InterPro:IPR005025,InterPro:IPR029039,UniProtKB/TrEMBL:I6Y946,NCBI_GP:CCP43673.1;Name=CCP43673.1;Note=Rv0925c%2C (MTCY21C12.19c)%2C len: 245 aa. Conserved protein%2C similar to AL132991|SCF55_19 hypothetical protein from Streptomyces coelicolor (197 aa)%2C FASTA scores: opt: 459%2C E(): 1.2e-23%2C (39.3%25 identity in 201 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0925c;product=Conserved protein;protein_id=CCP43673.1;transl_table=11
AL123456.3	EMBL	gene	1032710	1033786	.	-	.	ID=gene-Rv0926c;Name=Rv0926c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0926c
AL123456.3	EMBL	CDS	1032710	1033786	.	-	0	ID=cds-CCP43674.1;Parent=gene-Rv0926c;Dbxref=EnsemblGenomes-Gn:Rv0926c,EnsemblGenomes-Tr:CCP43674,GOA:I6WZS8,InterPro:IPR000846,InterPro:IPR016040,UniProtKB/TrEMBL:I6WZS8,NCBI_GP:CCP43674.1;Name=CCP43674.1;Note=Rv0926c%2C (MTCY21C12.20c)%2C len: 358 aa. Conserved hypothetical protein%2C similar to Rv1059 conserved hypothetical protein from Mycobacterium tuberculosis (354 aa). Also shows some similarity to AF170923|AF170923_3 dihydrodipicolinate reductase from Mastigocladus laminosus (278 aa)%2C FASTA scores: opt: 170%2C E(): 0.00088%2C (25.7%25 identity in 276 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0926c;product=Conserved hypothetical protein;protein_id=CCP43674.1;transl_table=11
AL123456.3	EMBL	gene	1033840	1034631	.	-	.	ID=gene-Rv0927c;Name=Rv0927c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0927c
AL123456.3	EMBL	CDS	1033840	1034631	.	-	0	ID=cds-CCP43675.1;Parent=gene-Rv0927c;Dbxref=EnsemblGenomes-Gn:Rv0927c,EnsemblGenomes-Tr:CCP43675,GOA:P9WGQ5,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP43675.1;Name=CCP43675.1;Note=Rv0927c%2C (MTCY21C12.21c)%2C len: 263 aa. Probable short-chain dehydrogenase/reductase%2C similar to various dehydrogenases/reductases%2C notably 7-alpha-hydroxysteroid dehydrogenases and glucose 1-dehydrogenases e.g. P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa)%2C FASTA scores: opt: 551%2C E(): 1e-26%2C (39.5%25 identity in 248 aa overlap)%3B NP_252778.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa)%3B AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa)%3B etc. Also similar to other dehydrogenases from Mycobacterium tuberculosis e.g. MTCY09F9.36%2C E():1.4e-18%3B MTCY369.14%2C E():8e-17%3B MTCY02B10.14%2C E():2.5e-14%3B MTCY09F9.23c%2C E():1.5e-13%3B MTCY03C7.07%2C E():1.9e-13. Contains PS00061 Short-chain dehydrogenases/reductases family signature%2C and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0927c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP43675.1;transl_table=11
AL123456.3	EMBL	gene	1034903	1036015	.	+	.	ID=gene-Rv0928;Name=pstS3;gbkey=Gene;gene=pstS3;gene_biotype=protein_coding;gene_synonym=phoS2;locus_tag=Rv0928
AL123456.3	EMBL	CDS	1034903	1036015	.	+	0	ID=cds-CCP43676.1;Parent=gene-Rv0928;Dbxref=EnsemblGenomes-Gn:Rv0928,EnsemblGenomes-Tr:CCP43676,GOA:P9WGT7,InterPro:IPR005673,InterPro:IPR024370,NCBI_GP:CCP43676.1;Name=CCP43676.1;Note=Rv0928%2C (MTCY21C12.22)%2C len: 370 aa. PstS3 (previously known as phoS2)%2C phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below)%2C highly similar to others from Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1 phosphate-binding protein 3 precursor (328 aa)%2C FASTA scores: opt: 1772%2C E(): 0%2C (79.6%25 identity in 328 aa overlap)%3B and highly similar to others e.g. AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa). Also highly similar to Rv0932c|MTCY08D9.07|pstS2 phosphate-binding periplasmic lipoprotein (370 aa)%3B and Rv0934|pstS1 phosphate-binding periplasmic lipoprotein (374 aa) from Mycobacterium tuberculosis (Mycobacterium tuberculosis seems to have three PstS-like proteins%2C others being Rv0932c and Rv0934c). Contains lipoprotein signature (PS00013) at N-terminus. Belongs to family of phosphate receptors for bacterial ABC-type lipoprotein transporters.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pstS3;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0928;product=Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1);protein_id=CCP43676.1;transl_table=11
AL123456.3	EMBL	gene	1036028	1037002	.	+	.	ID=gene-Rv0929;Name=pstC2;gbkey=Gene;gene=pstC2;gene_biotype=protein_coding;locus_tag=Rv0929
AL123456.3	EMBL	CDS	1036028	1037002	.	+	0	ID=cds-CCP43677.1;Parent=gene-Rv0929;Dbxref=EnsemblGenomes-Gn:Rv0929,EnsemblGenomes-Tr:CCP43677,GOA:P9WG05,InterPro:IPR000515,InterPro:IPR011864,NCBI_GP:CCP43677.1;Name=CCP43677.1;Note=Rv0929%2C (MTCY21C12.23)%2C len: 324 aa. PstC2%2Cphosphate-transport integral membrane ABC transporter (see citations below)%2C highly similar to others e.g. NP_302394.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (319 aa)%3B CAB88474.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (336 aa)%3B NP_290359.1| NC_002655 high-affinity phosphate-specific transport system (cytoplasmic membrane component) from Escherichia coli strain O157:H7 (319 aa)%3B etc. Also similar to Rv935|MTCY08D9.04c|PSTC1 probable transmembrane ABC transporter component of phosphate uptake system from Mycobacterium tuberculosis (338 aa). Contains binding-protein-dependent transport systems inner membrane component signature (PS00402).;gbkey=CDS;gene=pstC2;inference=protein motif:PROSITE:PS00402;locus_tag=Rv0929;product=Phosphate-transport integral membrane ABC transporter PstC2;protein_id=CCP43677.1;transl_table=11
AL123456.3	EMBL	gene	1036999	1037925	.	+	.	ID=gene-Rv0930;Name=pstA1;gbkey=Gene;gene=pstA1;gene_biotype=protein_coding;locus_tag=Rv0930
AL123456.3	EMBL	CDS	1036999	1037925	.	+	0	ID=cds-CCP43678.1;Parent=gene-Rv0930;Dbxref=EnsemblGenomes-Gn:Rv0930,EnsemblGenomes-Tr:CCP43678,GOA:P9WG11,InterPro:IPR000515,InterPro:IPR005672,NCBI_GP:CCP43678.1;Name=CCP43678.1;Note=Rv0930%2C (MTCY21C12.24)%2C len: 308 aa. Probable pstA1%2Cphosphate-transport integral membrane ABC transporter (see citation below)%2C highly similar to others e.g. NP_302393.1|NC_002677 membrane-bound component of phosphate transport from Mycobacterium leprae (304 aa)%3B CAB88473.1|AL353816 phosphate ABC transport system permease protein from Streptomyces coelicolor (354 aa) (N-terminus longer)%3B NP_312689.1|NC_002695 phosphate transport system permease protein PstA from Escherichia coli strain O157:H7 (296 aa)%3B etc. Also similar to Rv0936|MTCY08D9.03c|PSTA2 probable transmembrane ABC transporter component of phosphate uptake system from Mycobacterium tuberculosis (301 aa).;gbkey=CDS;gene=pstA1;locus_tag=Rv0930;product=Probable phosphate-transport integral membrane ABC transporter PstA1;protein_id=CCP43678.1;transl_table=11
AL123456.3	EMBL	gene	1037920	1039914	.	-	.	ID=gene-Rv0931c;Name=pknD;gbkey=Gene;gene=pknD;gene_biotype=protein_coding;gene_synonym=mbk;locus_tag=Rv0931c
AL123456.3	EMBL	CDS	1037920	1039914	.	-	0	ID=cds-CCP43679.1;Parent=gene-Rv0931c;Dbxref=EnsemblGenomes-Gn:Rv0931c,EnsemblGenomes-Tr:CCP43679,GOA:P9WI79,InterPro:IPR000719,InterPro:IPR001258,InterPro:IPR008271,InterPro:IPR011009,InterPro:IPR011042,InterPro:IPR013017,InterPro:IPR017441,PDB:1RWI,PDB:1RWL,NCBI_GP:CCP43679.1;Name=CCP43679.1;Note=Rv0931c%2C (MTCY08D9.08)%2C len: 664 aa. PknD (alternate gene name: mbk)%2C transmembrane serine/threonine protein kinase (see citations below)%2C equivalent to CAB62227.1|AJ250200 putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa)%3B and highly similar in N-terminus to P54744|PKNB_MYCLE probable serine/threonine-specific protein kinase from Mycobacterium leprae (622 aa). Also highly similar to others%2Cparticularly in N-terminal half e.g. NP_243370.1|NC_002570 serine/threonine protein kinase from Bacillus halodurans (664 aa)%3B NP_268044.1|NC_002662 serine/threonine protein kinase from Lactococcus lactis (627 aa)%3B etc. Also highly similar to other serine/threonine protein kinases from Mycobacterium tuberculosis e.g. pknH (626 aa)%2C FASTA scores: opt: 1398%2C E: 0%2C (49.3%25 identity in 540 aa overlap)%3B pknE (566 aa)%3B pknB (626 aa)%3B Rv3524 (343 aa)%3B etc. Contains Hank's kinase subdomain. Contains two transmembrane segments%2C which flank a highly repetitive region%2C suggesting a receptor-like anchoring. Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation on a serine residue. Appears to be co-transcribed with Rv0932c|pstS2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknD;inference=protein motif:PROSITE:PS00108;locus_tag=Rv0931c;product=Transmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D);protein_id=CCP43679.1;transl_table=11
AL123456.3	EMBL	gene	1039936	1041048	.	-	.	ID=gene-Rv0932c;Name=pstS2;gbkey=Gene;gene=pstS2;gene_biotype=protein_coding;locus_tag=Rv0932c
AL123456.3	EMBL	CDS	1039936	1041048	.	-	0	ID=cds-CCP43680.1;Parent=gene-Rv0932c;Dbxref=EnsemblGenomes-Gn:Rv0932c,EnsemblGenomes-Tr:CCP43680,GOA:P9WGT9,InterPro:IPR005673,InterPro:IPR006059,NCBI_GP:CCP43680.1;Name=CCP43680.1;Note=Rv0932c%2C (MTCY08D9.07)%2C len: 370 aa. PstS2%2Cphosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below)%2C highly similar to AAF74819.1|AF137360_1|AF137360 periplasmic phosphate permease from Mycobacterium avium (369 aa)%3B Rv0928|MTCY21C12.22|pstS3 phosphate-binding periplasmic lipoprotein from Mycobacterium tuberculosis (370 aa)%2C FASTA scores: opt: 1601%2C E(): 0%2C (64.5%25 identity in 372 aa overlap)%3B and Rv0934|MTCY08D9.05c|pstS1 phosphate-binding periplasmic lipoprotein from Mycobacterium tuberculosis (374 aa) (Mycobacterium tuberculosis seems to have three PstS-like proteins%2C others being Rv0928 and Rv0934c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU protein antigen B precursor from Mycobacterium tuberculosis (374 aa)%2C FASTA scores: opt: 460%2C E(): 2.7e-20%2C (31.2%25 identity in 375 aa overlap). Contains prokaryotic membrane lipoprotein lipid attachment site (PS00013) at N-terminus so the leader peptide of 22 aa is probably removed. Belongs to family of phosphate receptors for bacterial ABC-type lipoprotein transporters. Appears to be co-transcribed with Rv0931c|pknD|mbk.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pstS2;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0932c;product=Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2);protein_id=CCP43680.1;transl_table=11
AL123456.3	EMBL	gene	1041264	1042094	.	+	.	ID=gene-Rv0933;Name=pstB;gbkey=Gene;gene=pstB;gene_biotype=protein_coding;locus_tag=Rv0933
AL123456.3	EMBL	CDS	1041264	1042094	.	+	0	ID=cds-CCP43681.1;Parent=gene-Rv0933;Dbxref=EnsemblGenomes-Gn:Rv0933,EnsemblGenomes-Tr:CCP43681,GOA:P9WQK9,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR005670,InterPro:IPR015850,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP43681.1;Name=CCP43681.1;Note=Rv0933%2C (MTCY08D9.06c)%2C len: 276 aa. PstB%2Cphosphate-transport ATP-binding protein ABC transporter (see citations below)%2C thermostable ATPase%2C highly similar to others e.g. NP_348334.1|NC_003030 ATPase component of ABC-type phosphate transport system from Clostridium acetobutylicum (249 aa)%3B NP_212352.1|NC_001318 phosphate ABC transporter ATP-binding protein (pstB) from Borrelia burgdorferi (260 aa)%3B NP_390375.1|NC_000964 phosphate ABC transporter (ATP-binding protein) from Bacillus subtilis (269 aa)%2C FASTA scores: opt: 762%2C E(): 0%2C (47.7%25 identity in 243 aa overlap)%3B etc. Also similar to other M. tuberculosis ABC transporters e.g. MTCY253.24%2C E(): 2.5e-15 and MTCY359.14c%2C E(): 3.4e-15. Contains PS00211 ABC transporters family signature%2C and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters). Magnesium or calcium seem to have no influence on the functionality of this enzyme.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pstB;inference=protein motif:PROSITE:PS00211;locus_tag=Rv0933;product=Phosphate-transport ATP-binding protein ABC transporter PstB;protein_id=CCP43681.1;transl_table=11
AL123456.3	EMBL	gene	1042115	1043239	.	+	.	ID=gene-Rv0934;Name=pstS1;gbkey=Gene;gene=pstS1;gene_biotype=protein_coding;gene_synonym=phoS,phoS1;locus_tag=Rv0934
AL123456.3	EMBL	CDS	1042115	1043239	.	+	0	ID=cds-CCP43682.1;Parent=gene-Rv0934;Dbxref=EnsemblGenomes-Gn:Rv0934,EnsemblGenomes-Tr:CCP43682,GOA:P9WGU1,InterPro:IPR005673,InterPro:IPR006059,PDB:1PC3,NCBI_GP:CCP43682.1;Name=CCP43682.1;Note=Rv0934%2C (MTCY08D9.05c)%2C len: 374 aa. PstS1 (previously known as phoS1 or phoS)%2C phosphate-binding lipoprotein component of inorganic phosphate transport system (see citations below)%2C highly similar to Rv0932c|MTCY08D9.07|pstS2 phosphate-binding periplasmic lipoprotein from Mycobacterium tuberculosis (370 aa)%2C FASTA scores: opt: 460%2C E(): 5.9e-19%2C (31.2%25 identity in 375 aa overlap)%3B and Rv0928|MTCY21C12.22|pstS3 phosphate-binding periplasmic lipoprotein from Mycobacterium tuberculosis (374 aa)%2C FASTA scores: opt: 435%2C E():1.1e-17%2C (30.0%25 identity in 380 aa overlap) (Mycobacterium tuberculosis seems to have three PstS-like proteins%2C others being Rv0932c and Rv0928c). Also highly similar to MTCY08D9.05c|P15712|PAB_MYCTU protein antigen B precursor from Mycobacterium tuberculosis (374 aa)%2C FASTA scores: opt: 2459%2C E(): 0%2C (100%25 identity in 374 aa overlap). Contains a prokaryotic membrane lipoprotein lipid attachment site (PS00013) at the N-terminus so the 23 aa leader peptide sequence is probably removed. Belongs to family of phosphate receptors for bacterial ABC-type lipoprotein transporters.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pstS1;inference=protein motif:PROSITE:PS00013;locus_tag=Rv0934;product=Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1);protein_id=CCP43682.1;transl_table=11
AL123456.3	EMBL	gene	1043299	1044315	.	+	.	ID=gene-Rv0935;Name=pstC1;gbkey=Gene;gene=pstC1;gene_biotype=protein_coding;locus_tag=Rv0935
AL123456.3	EMBL	CDS	1043299	1044315	.	+	0	ID=cds-CCP43683.1;Parent=gene-Rv0935;Dbxref=EnsemblGenomes-Gn:Rv0935,EnsemblGenomes-Tr:CCP43683,GOA:P9WG07,InterPro:IPR000515,InterPro:IPR011864,NCBI_GP:CCP43683.1;Name=CCP43683.1;Note=Rv0935%2C (MTCY08D9.04c)%2C len: 338 aa. PstC1%2Cphosphate-transport integral membrane ABC transporter (see citations below)%2C highly similar to others e.g. NP_104768.1|NC_002678|pstC phosphate ABC transporter permease protein from Mesorhizobium loti (327 aa)%3B NP_245372.1|NC_002663|PstC PstC protein from Pasteurella multocida (320 aa)%3B P45191|PSTC_HAEIN phosphate transport system permease from Haemophilus influenza (315 aa)%2C FASTA scores: opt: 667%2C E(): 0%2C (36.2%25 identity in 309 aa overlap)%3B etc. Also similar to Rv0929|MTCY21C12.23|PSTC2 probable transmembrane ABC transporter component of phosphate uptake system from Mycobacterium tuberculosis (324 aa)%2C FASTA scores: opt: 487%2C E(): 4.1e-21%2C (32.3%25 identity in 303 aa overlap)%3B and shows slight similarity to MTCY08D9.03c|PSTA2|Rv0936 probable transmembrane ABC transporter component of phosphate uptake system from Mycobacterium tuberculosis (301 aa). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pstC1;inference=protein motif:PROSITE:PS00402;locus_tag=Rv0935;product=Phosphate-transport integral membrane ABC transporter PstC1;protein_id=CCP43683.1;transl_table=11
AL123456.3	EMBL	gene	1044317	1045222	.	+	.	ID=gene-Rv0936;Name=pstA2;gbkey=Gene;gene=pstA2;gene_biotype=protein_coding;locus_tag=Rv0936
AL123456.3	EMBL	CDS	1044317	1045222	.	+	0	ID=cds-CCP43684.1;Parent=gene-Rv0936;Dbxref=EnsemblGenomes-Gn:Rv0936,EnsemblGenomes-Tr:CCP43684,GOA:P9WG09,InterPro:IPR000515,InterPro:IPR005672,NCBI_GP:CCP43684.1;Name=CCP43684.1;Note=Rv0936%2C (MTCY08D9.03c)%2C len: 301 aa. PstA2%2Cphosphate-transport integral membrane ABC transporter (see citations below)%2C highly similar to others e.g. NP_442269.1|NC_000911|PstA phosphate transport system permease protein from Synechocystis sp. strain PCC 6803 (287 aa)%3B NP_232473.1|NC_002506 phosphate ABC transporter permease protein from Vibrio cholerae (289 aa)%3B P07654|PSTA_ECOLI phosphate transport system permease from Escherichia coli (296 aa)%2C FASTA scores: opt: 464%2C E(): 6.7e-24%2C (30.5%25 identity in 282 aa overlap)%3B etc. Also similar to O86345|MTCY21C12.24|PSTA1|Rv0930 probable transmembrane ABC transporter component of phosphate uptake system from Mycobacterium tuberculosis (304 aa)%2C FASTA scores: opt: 369%2C E(): 6.1e-15%2C (32.7%25 identity in 248 aa overlap). Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pstA2;inference=protein motif:PROSITE:PS00402;locus_tag=Rv0936;product=Phosphate-transport integral membrane ABC transporter PstA2;protein_id=CCP43684.1;transl_table=11
AL123456.3	EMBL	gene	1045199	1046020	.	-	.	ID=gene-Rv0937c;Name=mku;gbkey=Gene;gene=mku;gene_biotype=protein_coding;locus_tag=Rv0937c
AL123456.3	EMBL	CDS	1045199	1046020	.	-	0	ID=cds-CCP43685.1;Parent=gene-Rv0937c;Dbxref=EnsemblGenomes-Gn:Rv0937c,EnsemblGenomes-Tr:CCP43685,GOA:P9WKD9,InterPro:IPR006164,InterPro:IPR009187,InterPro:IPR016194,NCBI_GP:CCP43685.1;Name=CCP43685.1;Note=Rv0937c%2C (MTCY08D9.02)%2C len: 273 aa. Mku%2C DNA end-binding protein%2C highly similar to others e.g. SC6G9.24c|T35620|AL079356 hypothetical protein from Streptomyces coelicolor (365 aa)%2C FASTA scores: opt: 648%2CE(): 0%2C (36.5%25 identity in 274 aa overlap)%3B Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical proteins from Bacillus subtilis (311 aa)%2C FASTA scores: opt: 623%2C E(): 1.1e-31%2C (33.9%25 identity in 274 aa overlap)%3B O28548|AE000984|AF1726|NP_070554.1|NC_000917 conserved hypothetical protein from Archaeoglobus fulgidus (286 aa)%2CFASTA scores: opt: 583%2C E(): 0%2C (36.6%25 identity in 262 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mku;locus_tag=Rv0937c;product=DNA end-binding protein%2C Mku;protein_id=CCP43685.1;transl_table=11
AL123456.3	EMBL	gene	1046136	1048415	.	+	.	ID=gene-Rv0938;Name=ligD;gbkey=Gene;gene=ligD;gene_biotype=protein_coding;locus_tag=Rv0938
AL123456.3	EMBL	CDS	1046136	1048415	.	+	0	ID=cds-CCP43686.1;Parent=gene-Rv0938;Dbxref=EnsemblGenomes-Gn:Rv0938,EnsemblGenomes-Tr:CCP43686,GOA:P9WNV3,InterPro:IPR002755,InterPro:IPR012309,InterPro:IPR012310,InterPro:IPR012340,InterPro:IPR014144,InterPro:IPR014145,InterPro:IPR014146,PDB:1VS0,PDB:2IRU,PDB:2IRX,PDB:2IRY,PDB:2R9L,PDB:3PKY,PDB:4MKY,NCBI_GP:CCP43686.1;Name=CCP43686.1;Note=Rv0938%2C (MTCY08D9.01c%2C MTCY10D7.36c)%2C len: 759 aa. ligD%2C ATP-dependent DNA ligase%2C with its C-terminus similar to N-terminal parts of many ATP-dependent DNA ligases e.g. NP_250828.1|NC_002516 probable ATP-dependent DNA ligase from Pseudomonas aeruginosa (840 aa)%3B NP_105436.1|NC_002678 ATP-dependent DNA ligase from Mesorhizobium loti (829 aa)%3B CAB92891.1|AL356932 probable ATP-dependent DNA ligase from Streptomyces coelicolor (326 aa)%3B etc. The N-terminal half shows similarity with hypothetical proteins from Mycobacterium tuberculosis Rv0269c and Rv3730c%3B and the C-terminal half with the DNA ligases Rv3731 and Rv3062.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ligD;locus_tag=Rv0938;product=ATP dependent DNA ligase LigD (ATP dependent polydeoxyribonucleotide synthase) (thermostable DNA ligase) (ATP dependent polynucleotide ligase) (sealase) (DNA repair enzyme) (DNA joinase);protein_id=CCP43686.1;transl_table=11
AL123456.3	EMBL	gene	1048412	1050346	.	+	.	ID=gene-Rv0939;Name=Rv0939;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0939
AL123456.3	EMBL	CDS	1048412	1050346	.	+	0	ID=cds-CCP43687.1;Parent=gene-Rv0939;Dbxref=EnsemblGenomes-Gn:Rv0939,EnsemblGenomes-Tr:CCP43687,GOA:O86346,InterPro:IPR001279,InterPro:IPR002529,InterPro:IPR011234,UniProtKB/TrEMBL:O86346,NCBI_GP:CCP43687.1;Name=CCP43687.1;Note=Rv0939%2C (MTCY10D7.35c)%2C len: 644 aa. Possible bifunctional enzyme%2C including 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase activity%2C and cyclase/dehydrase activity. N-terminal part similar to many isomerases e.g. NP_343861.1|NC_002754 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase (hpcE-1) from Sulfolobus solfataricus (318 aa)%3B NP_068932.1|NC_000917 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase (hpcE-1) from Archaeoglobus fulgidus (324 aa)%2C FASTA scores: opt: 400%2CE(): 5.8e-15%2C (33.9%25 identity in 289 aa overlap)%3B etc. And C-terminal part highly similar to many cyclases/dehydrases e.g. AAK61721.1|AY033994 cyclase-like protein from Streptomyces aureofaciens (305 aa)%3B CAC44204.1|AL593842 cyclase from Streptomyces coelicolor (297 aa)%2C FASTA scores: opt: 375%2C E(): 2.7e-26%2C (35.6%25 identity in 284 aa overlap)%3B NP_343860.1|NC_002754 putative Cyclase/dehydrase from Sulfolobus solfataricus (308 aa)%3B etc. Also similar to Rv2993c hypothetical protein from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0939;product=Possible bifunctional enzyme: 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase;protein_id=CCP43687.1;transl_table=11
AL123456.3	EMBL	gene	1050593	1051459	.	-	.	ID=gene-Rv0940c;Name=Rv0940c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0940c
AL123456.3	EMBL	CDS	1050593	1051459	.	-	0	ID=cds-CCP43688.1;Parent=gene-Rv0940c;Dbxref=EnsemblGenomes-Gn:Rv0940c,EnsemblGenomes-Tr:CCP43688,GOA:P9WKP1,InterPro:IPR011251,InterPro:IPR019921,NCBI_GP:CCP43688.1;Name=CCP43688.1;Note=Rv0940c%2C (MTCY10D7.34)%2C len: 288 aa. Possible oxidoreductase%2C similar to hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa)%3B AAG52987.1|AF040570|Rif17 putative alkanal monooxygenase from Amycolatopsis mediterranei (356 aa)%3B etc. Also similar to putative oxidoreductases from Mycobacterium tuberculosis such as Rv0953c|P71557|YT21_MYCTU (282 aa)%2C FASTA scores: opt: 311%2CE(): 3.7e-08%2C (31.0%25 identity in 248 aa overlap)%2C Rv3079c (275 aa)%2C Rv0791c (347 aa)%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0940c;product=Possible oxidoreductase;protein_id=CCP43688.1;transl_table=11
AL123456.3	EMBL	gene	1051544	1052317	.	-	.	ID=gene-Rv0941c;Name=Rv0941c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0941c
AL123456.3	EMBL	CDS	1051544	1052317	.	-	0	ID=cds-CCP43689.1;Parent=gene-Rv0941c;Dbxref=EnsemblGenomes-Gn:Rv0941c,EnsemblGenomes-Tr:CCP43689,InterPro:IPR002645,UniProtKB/TrEMBL:P71568,NCBI_GP:CCP43689.1;Name=CCP43689.1;Note=Rv0941c%2C (MTCY10D7.33)%2C len: 257 aa. Conserved hypothetical protein%2C showing some similarity with parts of several hypothetical proteins from Streptomyces coelicolor e.g. AL035161|SC9C7_20 (860 aa)%2C FASTA scores: opt: 197%2CE(): 2.6e-05%2C (34.2%25 identity in 114 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0941c;product=Conserved hypothetical protein;protein_id=CCP43689.1;transl_table=11
AL123456.3	EMBL	gene	1052360	1052638	.	+	.	ID=gene-Rv0942;Name=Rv0942;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0942
AL123456.3	EMBL	CDS	1052360	1052638	.	+	0	ID=cds-CCP43690.1;Parent=gene-Rv0942;Dbxref=EnsemblGenomes-Gn:Rv0942,EnsemblGenomes-Tr:CCP43690,NCBI_GP:CCP43690.1;Name=CCP43690.1;Note=Rv0942%2C (MTCY10D7.32c)%2C len: 92 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0942;product=Hypothetical protein;protein_id=CCP43690.1;transl_table=11
AL123456.3	EMBL	gene	1052696	1053736	.	-	.	ID=gene-Rv0943c;Name=Rv0943c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0943c
AL123456.3	EMBL	CDS	1052696	1053736	.	-	0	ID=cds-CCP43691.1;Parent=gene-Rv0943c;Dbxref=EnsemblGenomes-Gn:Rv0943c,EnsemblGenomes-Tr:CCP43691,GOA:P9WKN7,NCBI_GP:CCP43691.1;Name=CCP43691.1;Note=Rv0943c%2C (MTCY10D7.31)%2C len: 346 aa. Possible monooxygenase%2C similar in part to others e.g. NP_250229.1|NC_002516 probable flavin-containing monooxygenase from Pseudomonas aeruginosa (527 aa)%3B AAC36351.1|AF090329 cyclohexanone monooxygenase homolog from Pseudomonas fluorescens (437 aa)%3B CAB59668.1|AL132674 monooxygenase from Streptomyces coelicolor (519 aa)%3B etc. Also similar to putative monooxygenases from Mycobacterium tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa). FASTA scores: opt: 129%2C E(): 8.5e-21%2C (27.5%25 identity in 236 aa overlap)%3B Rv0892 (495 aa)%3B Rv3049c (524 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0943c;product=Probable monooxygenase;protein_id=CCP43691.1;transl_table=11
AL123456.3	EMBL	gene	1053765	1054241	.	+	.	ID=gene-Rv0944;Name=Rv0944;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0944
AL123456.3	EMBL	CDS	1053765	1054241	.	+	0	ID=cds-CCP43692.1;Parent=gene-Rv0944;Dbxref=EnsemblGenomes-Gn:Rv0944,EnsemblGenomes-Tr:CCP43692,GOA:L0T864,InterPro:IPR000214,InterPro:IPR010663,InterPro:IPR010979,InterPro:IPR015886,NCBI_GP:CCP43692.1;Name=CCP43692.1;Note=Rv0944%2C (MTCY10D7.30c)%2C len: 158 aa. Possible formamidopyrimidine-DNA glycosylase%2C similar to C-terminus of formamidopyrimidine-DNA glycosylases e.g. CAB63194.1|AL133469 putative formamidopyrimidine-DNA glycosylase from Streptomyces coelicolor (287 aa)%3B FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA glycosylase from Lactococcus lactis subsp. lactis (273 aa)%2CFASTA scores: opt: 246%2C E(): 2.4e-09%2C (28.9%25 identity in 142 aa overlap)%3B O50606|FPG_THETH|MUTM|FPG formamidopyrimidine-DNA glycosylase from Thermus thermophilus (267 aa)%3B etc. Also similar to C-termini of endonucleases or DNA glycosylases of Mycobacterium tuberculosis e.g. Rv3297%2C Rv2464c%2C Rv2924c. May belong to the FPG family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0944;product=Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase);protein_id=CCP43692.1;transl_table=11
AL123456.3	EMBL	gene	1054247	1055008	.	+	.	ID=gene-Rv0945;Name=Rv0945;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0945
AL123456.3	EMBL	CDS	1054247	1055008	.	+	0	ID=cds-CCP43693.1;Parent=gene-Rv0945;Dbxref=EnsemblGenomes-Gn:Rv0945,EnsemblGenomes-Tr:CCP43693,GOA:P9WGR7,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP43693.1;Name=CCP43693.1;Note=Rv0945%2C (MTCY10D7.29c)%2C len: 253 aa. Probable short-chain dehydrogenase/reductase%2C similar to various dehydrogenases/reductases e.g. NP_346338.1|NC_003028 oxidoreductase (short chain dehydrogenase/reductase family) from Streptococcus pneumoniae (253 aa)%3B AAB70845.1|AF019986|PksB from Dictyostelium discoideum (260 aa)%3B AAF86624.1|U87786 clavaldehyde dehydrogenase from Streptomyces clavuligerus (247 aa)%3B P37440|UCPA_ECOLI oxidoreductase from Escherichia coli (285 aa)%2C FASTA scores: opt: 275%2C E(): 1.1e-12%2C (33.8%25 identity in 201 aa overlap)%3B etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv0945;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP43693.1;transl_table=11
AL123456.3	EMBL	gene	1055024	1056685	.	-	.	ID=gene-Rv0946c;Name=pgi;gbkey=Gene;gene=pgi;gene_biotype=protein_coding;locus_tag=Rv0946c
AL123456.3	EMBL	CDS	1055024	1056685	.	-	0	ID=cds-CCP43694.1;Parent=gene-Rv0946c;Dbxref=EnsemblGenomes-Gn:Rv0946c,EnsemblGenomes-Tr:CCP43694,GOA:P9WN69,InterPro:IPR001672,InterPro:IPR018189,InterPro:IPR023096,PDB:2WU8,NCBI_GP:CCP43694.1;Name=CCP43694.1;Note=Rv0946c%2C (MTCY10D7.28)%2C len: 553 aa. Probable pgi%2Cglucose-6-phosphate isomerase%2C equivalent to NP_301236.1|NC_002677 glucose-6-phosphate isomerase from Mycobacterium leprae (554 aa)%3B and P96803|G6PI_MYCSM glucose-6-phosphate isomerase from Mycobacterium smegmatis (442 aa). Also highly similar to others e.g. T36015 glucose-6-phosphate isomerase from Streptomyces coelicolor (551 aa)%3B P11537|G6PI_ECOLI|GPI glucose-6-phosphate isomerase from Escherichia coli strains K12 and O157:H7 (549 aa)%2C FASTA scores: opt: 1779%2C E(): 0%2C (51.4%25 identity in 554 aa overlap)%3B etc. Contains PS00765 Phosphoglucose isomerase signature 1%2C and PS00174 Phosphoglucose isomerase signature 2. Belongs to the GPI family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pgi;inference=protein motif:PROSITE:PS00765;locus_tag=Rv0946c;product=Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi);protein_id=CCP43694.1;transl_table=11
AL123456.3	EMBL	pseudogene	1057300	1057530	.	-	.	ID=gene-Rv0947c;Name=Rv0947c;gbkey=Gene;gene_biotype=pseudogene;locus_tag=Rv0947c;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	1057300	1057530	.	-	0	ID=cds-Rv0947c;Parent=gene-Rv0947c;Dbxref=PSEUDO:CCP43695.1;Note=Rv0947c%2C (MTCY10D7.27)%2C len: 76 aa. Probable mycolyl transferase pseudogene%2C similar to part of P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c) (fibronectin-binding protein C) from Mycobacterium tuberculosis (340 aa)%2C FASTA scores: opt: 213%2C E(): 2e-08%2C(69.6%25 identity in 46 aa overlap).;gbkey=CDS;locus_tag=Rv0947c;product=Probable mycolyl transferase%2C pseudogene;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	1057646	1057963	.	-	.	ID=gene-Rv0948c;Name=Rv0948c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0948c
AL123456.3	EMBL	CDS	1057646	1057963	.	-	0	ID=cds-CCP43696.1;Parent=gene-Rv0948c;Dbxref=EnsemblGenomes-Gn:Rv0948c,EnsemblGenomes-Tr:CCP43696,GOA:P9WIC1,InterPro:IPR002701,InterPro:IPR010958,InterPro:IPR020822,PDB:2QBV,PDB:2VKL,PDB:2W19,PDB:2W1A,NCBI_GP:CCP43696.1;Name=CCP43696.1;Note=Rv0948c%2C (MTCY10D7.26)%2C len: 105 aa. Chorismate mutase%2C AroQ class (See Prakash et al.%2C 2005%3B Schneider et al.%2C 2008)%2C equivalent to NP_301237.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (105 aa). Also similar (except in N-terminus) to SCD63.16c|CAB82023.1|AL161755 hypothetical protein from Streptomyces coelicolor (110 aa)%3B and to N-terminus of two chorismate mutase/prephenate dehydratase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0948c;product=Chorismate mutase;protein_id=CCP43696.1;transl_table=11
AL123456.3	EMBL	gene	1058260	1060575	.	+	.	ID=gene-Rv0949;Name=uvrD1;gbkey=Gene;gene=uvrD1;gene_biotype=protein_coding;gene_synonym=uvrD;locus_tag=Rv0949
AL123456.3	EMBL	CDS	1058260	1060575	.	+	0	ID=cds-CCP43697.1;Parent=gene-Rv0949;Dbxref=EnsemblGenomes-Gn:Rv0949,EnsemblGenomes-Tr:CCP43697,GOA:P9WMQ1,InterPro:IPR000212,InterPro:IPR005751,InterPro:IPR013986,InterPro:IPR014016,InterPro:IPR014017,InterPro:IPR027417,NCBI_GP:CCP43697.1;Name=CCP43697.1;Note=Rv0949%2C (MTCY10D7.25c)%2C len: 771 aa. Probable uvrD1%2CATP dependent DNA helicase II (see citation below)%2Cequivalent to P_301239.1|NC_002677 putative ATP-dependent DNA helicase from Mycobacterium leprae (778 aa). Also highly similar to others e.g. CAB92660.1|AL356832 from Streptomyces coelicolor (831 aa) (N-terminus longer)%3B P56255|PCRA_BACST from Bacillus stearothermophilus (724 aa)%3B Q10213|YAY5_SCHPO from Schizosaccharomyces pombe (Fission yeast) (887 aa)%2C FASTA scores: opt: 927%2C E(): 0%2C(33.5%25 identity in 659 aa overlap)%3B etc. Also similar to several other UvrD-like proteins in Mycobacterium tuberculosis e.g. Rv3201c%2C Rv3198c%2C Rv3202c. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the UVRD subfamily of helicases. Note that previously known as uvrD.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=uvrD1;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0949;product=Probable ATP-dependent DNA helicase II UvrD1;protein_id=CCP43697.1;transl_table=11
AL123456.3	EMBL	gene	1060656	1061654	.	-	.	ID=gene-Rv0950c;Name=Rv0950c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0950c
AL123456.3	EMBL	CDS	1060656	1061654	.	-	0	ID=cds-CCP43698.1;Parent=gene-Rv0950c;Dbxref=EnsemblGenomes-Gn:Rv0950c,EnsemblGenomes-Tr:CCP43698,InterPro:IPR011055,InterPro:IPR016047,UniProtKB/TrEMBL:P71560,NCBI_GP:CCP43698.1;Name=CCP43698.1;Note=Rv0950c%2C (MTCY10D7.24)%2C len: 332 aa. Conserved hypothetical protein%2C highly similar to AL035500|MLCL373.02c|T45433 hypothetical protein from Mycobacterium leprae (343 aa)%2C FASTA scores: opt: 1500%2CE(): 0%2C (71.0%25 identity in 331 aa overlap). C-terminus highly similar to part of various proteins e.g. C-terminal part of NP_441943.1|NC_000911|NlpD lipoprotein from Synechocystis sp (715 aa)%3B N-terminal part of NP_066789.1|NC_002576 putative peptidase from Rhodococcus equi (546 aa)%3B C-terminal part of NP_212396.1|NC_001318 conserved hypothetical protein from Borrelia burgdorferi (417 aa)%3B C-terminal part of P33648|NLPD_ECOLI|nlpd lipoprotein from Escherichia coli (379 aa)%2C FASTA scores: opt: 276%2C E(): 2e-10%2C (29.9%25 identity in 234 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0950c;product=Conserved hypothetical protein;protein_id=CCP43698.1;transl_table=11
AL123456.3	EMBL	gene	1061964	1063127	.	+	.	ID=gene-Rv0951;Name=sucC;gbkey=Gene;gene=sucC;gene_biotype=protein_coding;locus_tag=Rv0951
AL123456.3	EMBL	CDS	1061964	1063127	.	+	0	ID=cds-CCP43699.1;Parent=gene-Rv0951;Dbxref=EnsemblGenomes-Gn:Rv0951,EnsemblGenomes-Tr:CCP43699,GOA:P9WGC5,InterPro:IPR005809,InterPro:IPR005811,InterPro:IPR011761,InterPro:IPR013650,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016102,InterPro:IPR017866,NCBI_GP:CCP43699.1;Name=CCP43699.1;Note=Rv0951%2C (MTCY10D7.23c)%2C len: 387 aa. Probable sucC%2Csuccinyl-CoA synthetase%2C beta chain%2C equivalent to AL035500|MLCL373_3|NP_301241.1|NC_002677 succinyl-CoA synthase [beta] chain from Mycobacterium leprae (393 aa)%2CFASTA score: (86.7%25 identity in 391 aa overlap). Also highly similar to others e.g. AB92671.1|AL356832 succinyl-CoA synthetase beta chain from Streptomyces coelicolor (394 aa)%3B P25126|SUCC_THEFL succinyl-CoA synthetase beta chain from Thermus aquaticus (378 aa)%3B P07460|SUCC_ECOLI succinyl-CoA synthetase beta chain from Escherichia coli (388 aa)%2C FASTA scores: opt: 933%2C E(): 0%2C(41.0%25 identity in 390 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sucC;locus_tag=Rv0951;product=Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta);protein_id=CCP43699.1;transl_table=11
AL123456.3	EMBL	gene	1063140	1064051	.	+	.	ID=gene-Rv0952;Name=sucD;gbkey=Gene;gene=sucD;gene_biotype=protein_coding;locus_tag=Rv0952
AL123456.3	EMBL	CDS	1063140	1064051	.	+	0	ID=cds-CCP43700.1;Parent=gene-Rv0952;Dbxref=EnsemblGenomes-Gn:Rv0952,EnsemblGenomes-Tr:CCP43700,GOA:P9WGC7,InterPro:IPR003781,InterPro:IPR005810,InterPro:IPR005811,InterPro:IPR016040,InterPro:IPR016102,InterPro:IPR017440,NCBI_GP:CCP43700.1;Name=CCP43700.1;Note=Rv0952%2C (MTCY10D7.22c)%2C len: 303 aa. Probable sucD%2Csuccinyl-CoA synthetase%2C alpha chain%2C equivalent to AL035500|MLCL373_4|NP_301242.1|NC_002677 succinyl-CoA synthase [alpha] chain from Mycobacterium leprae (300 aa)%2CFASTA score: (86.3%25 identity in 300 aa overlap). Also highly similar to others e.g. CAB92672.1|AL356832 from Streptomyces coelicolor (294 aa)%3B P53591|SUCD_COXBU from Escherichia coli (288 aa)%2C FASTA scores: opt: 855%2C E(): 0%2C(53.8%25 identity in 286 aa overlap)%3B etc. Contains PS00399 ATP-citrate lyase and succinyl-CoA ligases active site%2C and PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sucD;inference=protein motif:PROSITE:PS00399;locus_tag=Rv0952;product=Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha);protein_id=CCP43700.1;transl_table=11
AL123456.3	EMBL	gene	1064114	1064962	.	-	.	ID=gene-Rv0953c;Name=Rv0953c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0953c
AL123456.3	EMBL	CDS	1064114	1064962	.	-	0	ID=cds-CCP43701.1;Parent=gene-Rv0953c;Dbxref=EnsemblGenomes-Gn:Rv0953c,EnsemblGenomes-Tr:CCP43701,GOA:P9WKN5,InterPro:IPR011251,InterPro:IPR019921,NCBI_GP:CCP43701.1;Name=CCP43701.1;Note=Rv0953c%2C (MTCY10D7.21)%2C len: 282 aa. Possible oxidoreductase%2C equivalent to CAA48222.1|X68102 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (166 aa). Similar to several hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa)%3B NP_070025.1|NC_000917 N5%2CN10-methylenetetrahydromethanopterin reductase (mer-2) from Archaeoglobus fulgidus (348 aa)%3B etc. Also similar to several hypothetical proteins and oxidoreductases from Mycobacterium tuberculosis e.g. Rv2161c|O06216|Z95388|MTCY270.07 (288 aa)%2C FASTA scores: opt: 633%2C E(): 0%2C (40.4%25 identity in 277 aa overlap)%2CRv3079c (275 aa)%2C Rv0791c (347 aa)%2C etc. Contains PS00201 Flavodoxin signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00201;locus_tag=Rv0953c;product=Possible oxidoreductase;protein_id=CCP43701.1;transl_table=11
AL123456.3	EMBL	gene	1065127	1066038	.	+	.	ID=gene-Rv0954;Name=Rv0954;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0954
AL123456.3	EMBL	CDS	1065127	1066038	.	+	0	ID=cds-CCP43702.1;Parent=gene-Rv0954;Dbxref=EnsemblGenomes-Gn:Rv0954,EnsemblGenomes-Tr:CCP43702,GOA:P9WIR9,NCBI_GP:CCP43702.1;Name=CCP43702.1;Note=Rv0954%2C (MTCY10D7.20c)%2C len: 303 aa. Probable conserved transmembrane protein%2C highly similar to 34KD_MYCPA|Q04959 34 kDa antigenic protein from Mycobacterium paratuberculosis (298 aa)%2C FASTA scores: opt: 1023%2C E(): 7.2e-36%2C (59.3%25 identity in 305 aa overlap)%3B AAC69251.1|U82111 34 kDa antigen precursor from Mycobacterium leprae (336 aa)%3B and AL035500|MLCL373.06 hypothetical membrane protein from Mycobacterium leprae (297 aa)%2C FASTA score: (55.6%25 identity in 315 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0954;product=Probable conserved transmembrane protein;protein_id=CCP43702.1;transl_table=11
AL123456.3	EMBL	gene	1066078	1067445	.	+	.	ID=gene-Rv0955;Name=Rv0955;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0955
AL123456.3	EMBL	CDS	1066078	1067445	.	+	0	ID=cds-CCP43703.1;Parent=gene-Rv0955;Dbxref=EnsemblGenomes-Gn:Rv0955,EnsemblGenomes-Tr:CCP43703,GOA:P9WKN3,NCBI_GP:CCP43703.1;Name=CCP43703.1;Note=Rv0955%2C (MTCY10D7.19c)%2C len: 455 aa. Probable conserved integral membrane protein%2C highly similar to AL035500|MLCL373_6 putative membrane protein from Mycobacterium leprae (430 aa)%2C FASTA score: (75.9%25 identity in 419 aa overlap)%3B and AAL05878.1|AF411607_2|AF411607 unknown protein from Mycobacterium avium subsp. paratuberculosis (409 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0955;product=Probable conserved integral membrane protein;protein_id=CCP43703.1;transl_table=11
AL123456.3	EMBL	gene	1067561	1068208	.	+	.	ID=gene-Rv0956;Name=purN;gbkey=Gene;gene=purN;gene_biotype=protein_coding;locus_tag=Rv0956
AL123456.3	EMBL	CDS	1067561	1068208	.	+	0	ID=cds-CCP43704.1;Parent=gene-Rv0956;Dbxref=EnsemblGenomes-Gn:Rv0956,EnsemblGenomes-Tr:CCP43704,GOA:P9WHM5,InterPro:IPR002376,InterPro:IPR004607,PDB:3DA8,PDB:3DCJ,NCBI_GP:CCP43704.1;Name=CCP43704.1;Note=Rv0956%2C (MTCY10D7.18c)%2C len: 215 aa. Probable purN%2C5'-phosphoribosylglycinamide formyltransferase%2C equivalent to AAF05726.1|AF191543_1|AF191543|PurN phosphoribosylglycinamide formyltransferase from Mycobacterium avium subsp. paratuberculosis (209 aa)%3B and AL035500|MLCL373_7 from Mycobacterium leprae (215 aa)%2CFASTA score: (79.4%25 identity in 214 aa overlap). Also highly similar to others e.g. BAA89443.1|AB003159 from Corynebacterium ammoniagenes (199 aa)%3B NP_241498.1|NC_002570 from Bacillus halodurans (188 aa)%3B P08179|PUR3_ECOLI|B2500 from Escherichia coli strain K12 (212 aa)%2C FASTA scores: opt: 380%2C E(): 2.4e-18%2C (36.6%25 identity in 183 aa overlap)%3B C-terminus of P16340|PUR2_DROPS trifunctional purine biosynthetic protein adenosine-3 from Drosophila pseudoobscura (Fruit fly) (1364 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purN;locus_tag=Rv0956;product=Probable 5'-phosphoribosylglycinamide formyltransferase PurN (GART) (gar transformylase) (5'-phosphoribosylglycinamide transformylase);protein_id=CCP43704.1;transl_table=11
AL123456.3	EMBL	gene	1068205	1069776	.	+	.	ID=gene-Rv0957;Name=purH;gbkey=Gene;gene=purH;gene_biotype=protein_coding;locus_tag=Rv0957
AL123456.3	EMBL	CDS	1068205	1069776	.	+	0	ID=cds-CCP43705.1;Parent=gene-Rv0957;Dbxref=EnsemblGenomes-Gn:Rv0957,EnsemblGenomes-Tr:CCP43705,GOA:P9WHM7,InterPro:IPR002695,InterPro:IPR011607,InterPro:IPR016193,InterPro:IPR024051,PDB:3ZZM,PDB:4A1O,NCBI_GP:CCP43705.1;Name=CCP43705.1;Note=Rv0957%2C (MTCY10D7.17c)%2C len: 523 aa. Probable purH%2Cbifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase and inosine-monophosphate (imp) cyclohydrolase%2C equivalent to AL035500|MLCL373_8 putative phosphoribosylaminoimidazolecarboxamide formyltransferase from Mycobacterium leprae (527 aa)%2C FASTA score: (88.1%25 identity in 520 aa overlap)%3B and AF05727.1|AF191543_2|AF191543|PurH from Mycobacterium avium subsp. paratuberculosis (527 aa). Also highly similar to others e.g. CAB92677.1|AL356832 bifunctional purine biosynthesis protein from Streptomyces coelicolor (523 aa)%3B NP_388534.1|NC_000964 phosphoribosylaminoimidazole carboxy formyl formyltransferase + inosine-monophosphate cyclohydrolase from Bacillus subtilis (512 aa)%3B P15639|PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase from Escherichia coli (529 aa)%2C FASTA scores: opt: 1147%2C E(): 0%2C (44.8%25 identity in 533 aa overlap)%3B etc. Belongs to the PurH family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purH;locus_tag=Rv0957;product=Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC);protein_id=CCP43705.1;transl_table=11
AL123456.3	EMBL	gene	1069883	1071262	.	+	.	ID=gene-Rv0958;Name=Rv0958;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0958
AL123456.3	EMBL	CDS	1069883	1071262	.	+	0	ID=cds-CCP43706.1;Parent=gene-Rv0958;Dbxref=EnsemblGenomes-Gn:Rv0958,EnsemblGenomes-Tr:CCP43706,GOA:P71552,InterPro:IPR002078,InterPro:IPR027417,UniProtKB/TrEMBL:P71552,NCBI_GP:CCP43706.1;Name=CCP43706.1;Note=Rv0958%2C (MTCY10D7.16c)%2C len: 459 aa. Possible magnesium chelatase%2C similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chelatase from Deinococcus radiodurans (487 aa)%2C FASTA scores: opt: 1148%2CE(): 0%2C (42.4%25 identity in 450 aa overlap)%3B Q44498|CHLI_ANAVA magnesium-chelatase subunit CHLI from Anabaena variabilis (338 aa)%3B T31460 probable magnesium chelatase chain I bchI from Heliobacillus mobilis (363 aa)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0958;product=Possible magnesium chelatase;protein_id=CCP43706.1;transl_table=11
AL123456.3	EMBL	gene	1071255	1073273	.	+	.	ID=gene-Rv0959;Name=Rv0959;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0959
AL123456.3	EMBL	CDS	1071255	1073273	.	+	0	ID=cds-CCP43707.1;Parent=gene-Rv0959;Dbxref=EnsemblGenomes-Gn:Rv0959,EnsemblGenomes-Tr:CCP43707,GOA:P9WKN1,InterPro:IPR002035,NCBI_GP:CCP43707.1;Name=CCP43707.1;Note=Rv0959%2C (MTCY10D7.15c)%2C len: 672 aa. Conserved hypothetical protein%2C similar to AE002069|AE002069_12 hypothetical protein from Deinococcus radiodurans (403 aa)%2CFASTA scores: opt: 395%2C E(): 1.3e-15%2C (26.8%25 identity in 426 aa overlap). Contains a single copy at the N-terminus of a short repeat found three times in the M. tuberculosis ORF O33341|MTV003.05c|AL008883.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0959;product=Conserved hypothetical protein;protein_id=CCP43707.1;transl_table=11
AL123456.3	EMBL	gene	1073327	1073548	.	+	.	ID=gene-Rv0959A;Name=vapB9;gbkey=Gene;gene=vapB9;gene_biotype=protein_coding;locus_tag=Rv0959A
AL123456.3	EMBL	CDS	1073327	1073548	.	+	0	ID=cds-CCP43708.1;Parent=gene-Rv0959A;Dbxref=EnsemblGenomes-Gn:Rv0959A,EnsemblGenomes-Tr:CCP43708,GOA:P9WJ55,InterPro:IPR010985,NCBI_GP:CCP43708.1;Name=CCP43708.1;Note=Rv0959A%2C len: 73 aa. Possible vapB9%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv0960 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Weakly similar to others in Mycobacterium tuberculosis e.g. Rv1721c;gbkey=CDS;gene=vapB9;locus_tag=Rv0959A;product=Possible antitoxin VapB9;protein_id=CCP43708.1;transl_table=11
AL123456.3	EMBL	gene	1073545	1073928	.	+	.	ID=gene-Rv0960;Name=vapC9;gbkey=Gene;gene=vapC9;gene_biotype=protein_coding;locus_tag=Rv0960
AL123456.3	EMBL	CDS	1073545	1073928	.	+	0	ID=cds-CCP43709.1;Parent=gene-Rv0960;Dbxref=EnsemblGenomes-Gn:Rv0960,EnsemblGenomes-Tr:CCP43709,GOA:P9WFA9,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43709.1;Name=CCP43709.1;Note=Rv0960%2C (MTCY10D7.14c)%2C len: 127 aa. Possible vapC9%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0959A%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Rv0065|MTV030.08 (133 aa)%2C FASTA scores: E(): 1.5e-14%2C (38.3%25 identity in 128 aa overlap)%2C Rv1720c (129 aa)%2C and Rv0549c (137 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC9;locus_tag=Rv0960;product=Possible toxin VapC9;protein_id=CCP43709.1;transl_table=11
AL123456.3	EMBL	gene	1074074	1074421	.	+	.	ID=gene-Rv0961;Name=Rv0961;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0961
AL123456.3	EMBL	CDS	1074074	1074421	.	+	0	ID=cds-CCP43710.1;Parent=gene-Rv0961;Dbxref=EnsemblGenomes-Gn:Rv0961,EnsemblGenomes-Tr:CCP43710,GOA:P9WKM9,NCBI_GP:CCP43710.1;Name=CCP43710.1;Note=Rv0961%2C (MTCY10D7.13c)%2C len: 115 aa. Probable integral membrane protein.;gbkey=CDS;locus_tag=Rv0961;product=Probable integral membrane protein;protein_id=CCP43710.1;transl_table=11
AL123456.3	EMBL	gene	1074440	1075114	.	-	.	ID=gene-Rv0962c;Name=lprP;gbkey=Gene;gene=lprP;gene_biotype=protein_coding;locus_tag=Rv0962c
AL123456.3	EMBL	CDS	1074440	1075114	.	-	0	ID=cds-CCP43711.1;Parent=gene-Rv0962c;Dbxref=EnsemblGenomes-Gn:Rv0962c,EnsemblGenomes-Tr:CCP43711,GOA:P9WK39,NCBI_GP:CCP43711.1;Name=CCP43711.1;Note=Rv0962c%2C (MTCY10D7.12)%2C len: 224 aa. Possible lprP%2Clipoprotein. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lprP;locus_tag=Rv0962c;product=Possible lipoprotein LprP;protein_id=CCP43711.1;transl_table=11
AL123456.3	EMBL	gene	1075297	1076097	.	-	.	ID=gene-Rv0963c;Name=Rv0963c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0963c
AL123456.3	EMBL	CDS	1075297	1076097	.	-	0	ID=cds-CCP43712.1;Parent=gene-Rv0963c;Dbxref=EnsemblGenomes-Gn:Rv0963c,EnsemblGenomes-Tr:CCP43712,InterPro:IPR010427,InterPro:IPR029058,NCBI_GP:CCP43712.1;Name=CCP43712.1;Note=Rv0963c%2C (MTCCY10D7.11)%2C len: 266 aa. Conserved hypothetical protein%2C similar in part to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2797c|MTCY16B7.46 (562 aa)%2C FASTA scores: E(): 1.2e-23%2C(39.0%25 identity in 254 aa overlap)%3B Rv2542 (403 aa)%3B Rv2079 (656 aa). Also similar in part to AL133423|SC4A7_3 hypothetical secreted protein from Streptomyces coelicolor (406 aa)%2C FASTA scores: opt: 231%2C E(): 6.8e-07%2C (31.4%25 identity in 204 aa overlap)%3B and SCH10.21c|T36533 hypothetical protein from Streptomyces coelicolor (329 aa).;gbkey=CDS;locus_tag=Rv0963c;product=Conserved hypothetical protein;protein_id=CCP43712.1;transl_table=11
AL123456.3	EMBL	gene	1076196	1076678	.	-	.	ID=gene-Rv0964c;Name=Rv0964c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0964c
AL123456.3	EMBL	CDS	1076196	1076678	.	-	0	ID=cds-CCP43713.1;Parent=gene-Rv0964c;Dbxref=EnsemblGenomes-Gn:Rv0964c,EnsemblGenomes-Tr:CCP43713,NCBI_GP:CCP43713.1;Name=CCP43713.1;Note=Rv0964c%2C (MTCY10D7.10)%2C len: 160 aa. Hypothetical unknown protein. Equivalent to AAK45241.1 from Mycobacterium tuberculosis strain CDC1551 (138 aa) but longer 22 aa.;gbkey=CDS;locus_tag=Rv0964c;product=Hypothetical protein;protein_id=CCP43713.1;transl_table=11
AL123456.3	EMBL	gene	1076778	1077197	.	-	.	ID=gene-Rv0965c;Name=Rv0965c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0965c
AL123456.3	EMBL	CDS	1076778	1077197	.	-	0	ID=cds-CCP43714.1;Parent=gene-Rv0965c;Dbxref=EnsemblGenomes-Gn:Rv0965c,EnsemblGenomes-Tr:CCP43714,NCBI_GP:CCP43714.1;Name=CCP43714.1;Note=Rv0965c%2C (MTCY10D7.09)%2C len: 139 aa. Conserved hypothetical protein%2C showing weak similarity with Rv2798c|MTCY16B7.45 conserved hypothetical protein from Mycobacterium tuberculosis (108 aa)%2C FASTA scores: E(): 5.6e-12%2C (38.9%25 identity in 90 aa overlap). Equivalent to AAK45242.1 from Mycobacterium tuberculosis strain CDC1551 (146 aa) but shorter 7 aa.;gbkey=CDS;locus_tag=Rv0965c;product=Conserved hypothetical protein;protein_id=CCP43714.1;transl_table=11
AL123456.3	EMBL	gene	1077233	1077835	.	-	.	ID=gene-Rv0966c;Name=Rv0966c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0966c
AL123456.3	EMBL	CDS	1077233	1077835	.	-	0	ID=cds-CCP43715.1;Parent=gene-Rv0966c;Dbxref=EnsemblGenomes-Gn:Rv0966c,EnsemblGenomes-Tr:CCP43715,GOA:P9WKM1,InterPro:IPR012551,NCBI_GP:CCP43715.1;Name=CCP43715.1;Note=Rv0966c%2C (MTCY10D7.08)%2C len: 200 aa. Conserved protein%2C equivalent to AL035500|MLCL373_12 conserved hypothetical protein from Mycobacterium leprae (200 aa)%2CFASTA scores: opt: 1080%2C E(): 0%2C (79.5%25 identity in 200 aa overlap). Also highly similar to SCE6.30c|CAB88834.1|AL353832 hypothetical protein from Streptomyces coelicolor (277 aa). Some similarity to Rv2862c|MTV007.08 conserved hypothetical protein from Mycobacterium tuberculosis (194 aa)%2C FASTA scores: E(): 3.1e-06%2C (31.5%25 identity in 184 aa overlap). Equivalent to AAK45243.1 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 30 aa. Note that Rv0966c has been shortened since first entry.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0966c;product=Conserved protein;protein_id=CCP43715.1;transl_table=11
AL123456.3	EMBL	gene	1077975	1078334	.	+	.	ID=gene-Rv0967;Name=csoR;gbkey=Gene;gene=csoR;gene_biotype=protein_coding;locus_tag=Rv0967
AL123456.3	EMBL	CDS	1077975	1078334	.	+	0	ID=cds-CCP43716.1;Parent=gene-Rv0967;Dbxref=EnsemblGenomes-Gn:Rv0967,EnsemblGenomes-Tr:CCP43716,GOA:P9WP49,InterPro:IPR003735,PDB:2HH7,NCBI_GP:CCP43716.1;Name=CCP43716.1;Note=Rv0967%2C (MTCY10D7.07c)%2C len: 119 aa. CsoR%2Ccopper-sensitive operon repressor%2C part of cso operon (See Liu et al.%2C 2007)%2C similar to hypothetical proteins from several organisms e.g. AE002074|AE002074_11 from Deinococcus radiodurans (102 aa)%2C FASTA scores: opt: 233%2CE(): 8.6e-10%2C (47.0%25 identity in 83 aa overlap)%3B O32222|Z99121|YVGZ from Bacillus subtilis (101 aa)%2C FASTA scores: opt:228%2C E(): 3.2e-15%2C (38.0%25 identity in 92 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0190%2C and Rv1766.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=csoR;locus_tag=Rv0967;product=Copper-sensitive operon repressor CsoR;protein_id=CCP43716.1;transl_table=11
AL123456.3	EMBL	gene	1078391	1078687	.	+	.	ID=gene-Rv0968;Name=Rv0968;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0968
AL123456.3	EMBL	CDS	1078391	1078687	.	+	0	ID=cds-CCP43717.1;Parent=gene-Rv0968;Dbxref=EnsemblGenomes-Gn:Rv0968,EnsemblGenomes-Tr:CCP43717,GOA:P9WKL9,InterPro:IPR009963,NCBI_GP:CCP43717.1;Name=CCP43717.1;Note=Rv0968%2C (MTCY10D7.06c)%2C len: 98 aa. Conserved protein%2C part of cso operon%2C similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Also highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv3269 (93 aa)%2C FASTA score: (51.1%25 identity in 94 aa overlap)%3B and Rv1993c (90 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0968;product=Conserved protein;protein_id=CCP43717.1;transl_table=11
AL123456.3	EMBL	gene	1078743	1081055	.	+	.	ID=gene-Rv0969;Name=ctpV;gbkey=Gene;gene=ctpV;gene_biotype=protein_coding;locus_tag=Rv0969
AL123456.3	EMBL	CDS	1078743	1081055	.	+	0	ID=cds-CCP43718.1;Parent=gene-Rv0969;Dbxref=EnsemblGenomes-Gn:Rv0969,EnsemblGenomes-Tr:CCP43718,GOA:P9WPS3,InterPro:IPR001757,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,InterPro:IPR027256,NCBI_GP:CCP43718.1;Name=CCP43718.1;Note=Rv0969%2C (MTCY10D7.05c)%2C len: 770 aa. Probable ctpV%2Cmetal cation transporter P-type ATPase (transmembrane protein) (see citation below)%2C part of cso operon%2C highly similar (except in N-terminus) to others e.g. NP_391230.1|NC_000964 similar to heavy metal-transporting ATPase from Bacillus subtilis (803 aa)%3B P37279|ATCS_SYNP7|PACS cation-transporting ATPase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (747 aa)%2C FASTA scores: opt: 1851%2C E(): 0%2C (52.1%25 identity in 664 aa overlap)%3B etc. Equivalent to AAK45246.1 from Mycobacterium tuberculosis strain CDC1551 (792 aa) but shorter 22 aa. Contains PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpV;inference=protein motif:PROSITE:PS00154;locus_tag=Rv0969;product=Probable metal cation transporter P-type ATPase CtpV;protein_id=CCP43718.1;transl_table=11
AL123456.3	EMBL	gene	1081052	1081684	.	+	.	ID=gene-Rv0970;Name=Rv0970;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0970
AL123456.3	EMBL	CDS	1081052	1081684	.	+	0	ID=cds-CCP43719.1;Parent=gene-Rv0970;Dbxref=EnsemblGenomes-Gn:Rv0970,EnsemblGenomes-Tr:CCP43719,GOA:P9WKL7,NCBI_GP:CCP43719.1;Name=CCP43719.1;Note=Rv0970%2C (MTCY10D7.04c)%2C len: 210 aa. Probable conserved integral membrane protein%2C part of cso operon%2Cequivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium leprae (210 aa).;gbkey=CDS;locus_tag=Rv0970;product=Probable conserved integral membrane protein;protein_id=CCP43719.1;transl_table=11
AL123456.3	EMBL	gene	1081775	1082584	.	-	.	ID=gene-Rv0971c;Name=echA7;gbkey=Gene;gene=echA7;gene_biotype=protein_coding;locus_tag=Rv0971c
AL123456.3	EMBL	CDS	1081775	1082584	.	-	0	ID=cds-CCP43720.1;Parent=gene-Rv0971c;Dbxref=EnsemblGenomes-Gn:Rv0971c,EnsemblGenomes-Tr:CCP43720,GOA:P71540,InterPro:IPR001753,InterPro:IPR014748,InterPro:IPR029045,UniProtKB/TrEMBL:P71540,NCBI_GP:CCP43720.1;Name=CCP43720.1;Note=Rv0971c%2C (MTCY10D7.03)%2C len: 269 aa. Probable echA7%2Cenoyl-CoA hydratase%2C similar to many e.g. CAB95895.1|AL359988 putative enoyl CoA hydratase from Streptomyces coelicolor (247 aa)%3B P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (257 aa)%2CFASTA scores: opt: 369%2C E(): 2.6e-15%2C (33.7%25 identity in 246 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA7;locus_tag=Rv0971c;product=Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43720.1;transl_table=11
AL123456.3	EMBL	gene	1082584	1083750	.	-	.	ID=gene-Rv0972c;Name=fadE12;gbkey=Gene;gene=fadE12;gene_biotype=protein_coding;locus_tag=Rv0972c
AL123456.3	EMBL	CDS	1082584	1083750	.	-	0	ID=cds-CCP43721.1;Parent=gene-Rv0972c;Dbxref=EnsemblGenomes-Gn:Rv0972c,EnsemblGenomes-Tr:CCP43721,GOA:P9WQG3,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,NCBI_GP:CCP43721.1;Name=CCP43721.1;Note=Rv0972c%2C (MTCY10D7.02)%2C len: 388 aa. fadE12%2Cacyl-CoA dehydrogenase%2C highly similar to many e.g. CAB95893.1|AL359988 putative acyl CoA dehydrogenase from Streptomyces coelicolor (382 aa)%3B P45857|ACDB_BACSU from Bacillus subtilis (379 aa)%2C FASTA scores: opt: 576%2C E(): 2.3e-26%2C (29.7%25 identity in 381 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE12;locus_tag=Rv0972c;product=Acyl-CoA dehydrogenase FadE12;protein_id=CCP43721.1;transl_table=11
AL123456.3	EMBL	gene	1083747	1085750	.	-	.	ID=gene-Rv0973c;Name=accA2;gbkey=Gene;gene=accA2;gene_biotype=protein_coding;gene_synonym=bccA;locus_tag=Rv0973c
AL123456.3	EMBL	CDS	1083747	1085750	.	-	0	ID=cds-CCP43722.1;Parent=gene-Rv0973c;Dbxref=EnsemblGenomes-Gn:Rv0973c,EnsemblGenomes-Tr:CCP43722,GOA:P71538,InterPro:IPR000089,InterPro:IPR001882,InterPro:IPR005479,InterPro:IPR005481,InterPro:IPR005482,InterPro:IPR011053,InterPro:IPR011054,InterPro:IPR011761,InterPro:IPR011764,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,UniProtKB/TrEMBL:P71538,NCBI_GP:CCP43722.1;Name=CCP43722.1;Note=Rv0973c%2C (MTV044.01c%2C MTCY10D7.01)%2C len: 667 aa. Probable accA2 (alternate gene name: bccA)%2Cacetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [includes: biotin carboxylase %3B biotin carboxyl carrier protein (BCCP)]%2C highly similar to others e.g. CAB95892.1|AL359988 putative acetyl/propionyl CoA carboxylase alpha subunit from Streptomyces coelicolor (614 aa)%3B NP_250702.1|NC_002516 probable acyl-CoA carboxylase alpha chain from Pseudomonas aeruginosa (655 aa)%3B NP_420971.1|NC_002696 acetyl/propionyl-CoA carboxylase alpha subunit from Caulobacter crescentus ( 654 aa)%3B NP_251581.1|NC_002516 probable biotin carboxylase/biotin carboxyl carrier protein from Pseudomonas aeruginosa (661 aa)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) (654 aa)%2C FASTA scores%2C opt: 250%2C E(): 4e-09%2C(28.6%25 identity in 182 aa overlap)%3B and Rv3285|MTCY71.25|ACCA3 (600 aa)%3B Z83018|MTCY349_20 (1127 aa)%2C FASTA scores: opt: 838%2C E(): 0%2C (40.2%25 identity in 500 aa overlap). Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accA2;inference=protein motif:PROSITE:PS00867;locus_tag=Rv0973c;product=Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP);protein_id=CCP43722.1;transl_table=11
AL123456.3	EMBL	gene	1085756	1087345	.	-	.	ID=gene-Rv0974c;Name=accD2;gbkey=Gene;gene=accD2;gene_biotype=protein_coding;locus_tag=Rv0974c
AL123456.3	EMBL	CDS	1085756	1087345	.	-	0	ID=cds-CCP43723.1;Parent=gene-Rv0974c;Dbxref=EnsemblGenomes-Gn:Rv0974c,EnsemblGenomes-Tr:CCP43723,GOA:O86318,InterPro:IPR000022,InterPro:IPR011762,InterPro:IPR011763,InterPro:IPR029045,UniProtKB/TrEMBL:O86318,NCBI_GP:CCP43723.1;Name=CCP43723.1;Note=Rv0974c%2C (MTV044.02c)%2C len: 529 aa. Probable accD2%2Cacetyl-/propionyl-CoA carboxylase (beta subunit)%2C highly similar to many e.g. CAB95891.1|AL35998 putative acetyl/propionyl CoA carboxylase beta subunit from Streptomyces coelicolor (532 aa)%3B NP_250704.1|NC_002516 probable acyl-CoA carboxyltransferase beta chain from Pseudomonas aeruginosa (535 aa)%3B BAB16296.1|AB039884 acetyl-CoA carboxylase carboxyltransferase from Myxococcus xanthus (538 aa)%3B NP_420973.1|NC_002696 putative propionyl-CoA carboxylase beta subunit from Caulobacter crescentus (530 aa)%3B etc. Also similar to other from Mycobacterium tuberculosis: Rv2502c|ACCD1%2C Rv3799c|ACCD4%2Cetc. Could belong to the ACCD/PCCB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accD2;locus_tag=Rv0974c;product=Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2;protein_id=CCP43723.1;transl_table=11
AL123456.3	EMBL	gene	1087348	1088496	.	-	.	ID=gene-Rv0975c;Name=fadE13;gbkey=Gene;gene=fadE13;gene_biotype=protein_coding;locus_tag=Rv0975c
AL123456.3	EMBL	CDS	1087348	1088496	.	-	0	ID=cds-CCP43724.1;Parent=gene-Rv0975c;Dbxref=EnsemblGenomes-Gn:Rv0975c,EnsemblGenomes-Tr:CCP43724,GOA:O86319,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:O86319,NCBI_GP:CCP43724.1;Name=CCP43724.1;Note=Rv0975c%2C (MTV044.03c)%2C len: 382 aa. Probable fadE13%2Cacyl-CoA dehydrogenase%2C highly similar to many e.g. T35427 probable acyl-CoA dehydrogenase from Streptomyces coelicolor (382 aa)%3B M74096|HUMACADL_1 Human long chain acyl-CoA dehydrogenase from Homo sapiens (430 aa)%2C FASTA scores: opt: 819%2C E(): 0%2C (37.0%25 identity in 376 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa)%2C FASTA scores: (40.3%25 identity in 375 aa overlap). Contains PS00073 Acyl-CoA dehydrogenases signature 2. Belongs to the acyl-CoA dehydrogenases family.;gbkey=CDS;gene=fadE13;inference=protein motif:PROSITE:PS00073;locus_tag=Rv0975c;product=Probable acyl-CoA dehydrogenase FadE13;protein_id=CCP43724.1;transl_table=11
AL123456.3	EMBL	gene	1088493	1090175	.	-	.	ID=gene-Rv0976c;Name=Rv0976c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0976c
AL123456.3	EMBL	CDS	1088493	1090175	.	-	0	ID=cds-CCP43725.1;Parent=gene-Rv0976c;Dbxref=EnsemblGenomes-Gn:Rv0976c,EnsemblGenomes-Tr:CCP43725,InterPro:IPR010839,UniProtKB/TrEMBL:O86320,NCBI_GP:CCP43725.1;Name=CCP43725.1;Note=Rv0976c%2C (MTV044.04c)%2C len: 560 aa. Conserved hypothetical protein%2C highly similar to others e.g. CAB95890.1|AL359988 conserved hypothetical protein from Streptomyces coelicolor (558 aa)%3B P_251576.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (600 aa)%3B etc. N-terminal part highly similar to AL035500|MLCL373_14 probable pseudogene from Mycobacterium leprae (163 aa)%2CFASTA score: (50.0%25 identity in 122 aa overlap).;gbkey=CDS;locus_tag=Rv0976c;product=Conserved hypothetical protein;protein_id=CCP43725.1;transl_table=11
AL123456.3	EMBL	gene	1090373	1093144	.	+	.	ID=gene-Rv0977;Name=PE_PGRS16;gbkey=Gene;gene=PE_PGRS16;gene_biotype=protein_coding;locus_tag=Rv0977
AL123456.3	EMBL	CDS	1090373	1093144	.	+	0	ID=cds-CCP43726.1;Parent=gene-Rv0977;Dbxref=EnsemblGenomes-Gn:Rv0977,EnsemblGenomes-Tr:CCP43726,GOA:Q79FU3,InterPro:IPR000084,PDB:4EHC,UniProtKB/TrEMBL:Q79FU3,NCBI_GP:CCP43726.1;Name=CCP43726.1;Note=Rv0977%2C (MTV044.05)%2C len: 923 aa. PE_PGRS16%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to other PGRS-type sequences e.g. AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa)%2C FASTA score: (45.4%25 identity in 959 aa overlap)%3B Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa)%2C FASTA score: (51.5%25 identity in 750 aa overlap)%3B etc.;gbkey=CDS;gene=PE_PGRS16;locus_tag=Rv0977;product=PE-PGRS family protein PE_PGRS16;protein_id=CCP43726.1;transl_table=11
AL123456.3	EMBL	gene	1093361	1094356	.	-	.	ID=gene-Rv0978c;Name=PE_PGRS17;gbkey=Gene;gene=PE_PGRS17;gene_biotype=protein_coding;locus_tag=Rv0978c
AL123456.3	EMBL	CDS	1093361	1094356	.	-	0	ID=cds-CCP43727.1;Parent=gene-Rv0978c;Dbxref=EnsemblGenomes-Gn:Rv0978c,EnsemblGenomes-Tr:CCP43727,InterPro:IPR000084,InterPro:IPR001258,InterPro:IPR011964,InterPro:IPR013017,InterPro:IPR015943,UniProtKB/TrEMBL:Q79FU2,NCBI_GP:CCP43727.1;Name=CCP43727.1;Note=Rv0978c%2C (MTV044.06c)%2C len: 331 aa. PE_PGRS17%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa)%2C FASTA score: (73.6%25 identity in 277 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS17;locus_tag=Rv0978c;product=PE-PGRS family protein PE_PGRS17;protein_id=CCP43727.1;transl_table=11
AL123456.3	EMBL	gene	1094670	1094864	.	-	.	ID=gene-Rv0979c;Name=Rv0979c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0979c
AL123456.3	EMBL	CDS	1094670	1094864	.	-	0	ID=cds-CCP43728.1;Parent=gene-Rv0979c;Dbxref=EnsemblGenomes-Gn:Rv0979c,EnsemblGenomes-Tr:CCP43728,UniProtKB/TrEMBL:O53892,NCBI_GP:CCP43728.1;Name=CCP43728.1;Note=Rv0979c%2C (MTV044.07c)%2C len: 64 aa (unlikely ORF). Hypothetical unknown protein. Start codon changed since first submission (-44 aa).;gbkey=CDS;locus_tag=Rv0979c;product=Hypothetical protein;protein_id=CCP43728.1;transl_table=11
AL123456.3	EMBL	gene	1094886	1095059	.	+	.	ID=gene-Rv0979A;Name=rpmF;gbkey=Gene;gene=rpmF;gene_biotype=protein_coding;locus_tag=Rv0979A
AL123456.3	EMBL	CDS	1094886	1095059	.	+	0	ID=cds-CCP43729.1;Parent=gene-Rv0979A;Dbxref=EnsemblGenomes-Gn:Rv0979A,EnsemblGenomes-Tr:CCP43729,GOA:P9WH99,InterPro:IPR002677,InterPro:IPR011332,NCBI_GP:CCP43729.1;Name=CCP43729.1;Note=Rv0979A%2C len: 57 aa. rpmF%2C 50S ribosomal protein L32%2C similar to others e.g. rpmF|Q9RL50 probable 50S ribosomal protein from Streptomyces coelicolor (56 aa)%2CFASTA scores: E(): 5.1e-09%2C (63.45%25 identity in 52 aa overlap)%3B etc. Belongs to the L32P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpmF;locus_tag=Rv0979A;product=50S ribosomal protein L32 RpmF;protein_id=CCP43729.1;transl_table=11
AL123456.3	EMBL	gene	1095078	1096451	.	-	.	ID=gene-Rv0980c;Name=PE_PGRS18;gbkey=Gene;gene=PE_PGRS18;gene_biotype=protein_coding;locus_tag=Rv0980c
AL123456.3	EMBL	CDS	1095078	1096451	.	-	0	ID=cds-CCP43730.1;Parent=gene-Rv0980c;Dbxref=EnsemblGenomes-Gn:Rv0980c,EnsemblGenomes-Tr:CCP43730,InterPro:IPR000084,InterPro:IPR001258,InterPro:IPR011045,InterPro:IPR011964,InterPro:IPR013017,InterPro:IPR015943,UniProtKB/TrEMBL:Q79FU0,NCBI_GP:CCP43730.1;Name=CCP43730.1;Note=Rv0980c%2C (MTV044.08c)%2C len: 457 aa. PE_PGRS18%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002)%2Chighly similar to others e.g. Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461 aa)%2C FASTA score: (66.7%25 identity in 405 aa overlap)%3B Z95844|MTCY493_2 from Mycobacterium tuberculosis (741 aa)%2C FASTA score: (53.0%25 identity in 394 aa overlap)%3B etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=PE_PGRS18;locus_tag=Rv0980c;product=PE-PGRS family protein PE_PGRS18;protein_id=CCP43730.1;transl_table=11
AL123456.3	EMBL	gene	1096822	1097508	.	+	.	ID=gene-Rv0981;Name=mprA;gbkey=Gene;gene=mprA;gene_biotype=protein_coding;locus_tag=Rv0981
AL123456.3	EMBL	CDS	1096822	1097508	.	+	0	ID=cds-CCP43731.1;Parent=gene-Rv0981;Dbxref=EnsemblGenomes-Gn:Rv0981,EnsemblGenomes-Tr:CCP43731,GOA:P9WGM9,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,NCBI_GP:CCP43731.1;Name=CCP43731.1;Note=Rv0981%2C (MTV044.09)%2C len: 228 aa. MprA%2Cmycobacterial persistence regulator%2C a two-component response regulator whose expression is required for entrance into and maintenance of persistent infection (see citation below)%2C equivalent to NP_301250.1|NC_002677 putative two-component response regulator from Mycobacterium leprae (228 aa)%3B and highly similar to others from Mycobacterium leprae. Also highly similar to others e.g. AAG36759.1|AF119221_1|AF119221 response regulator from Corynebacterium glutamicum (232 aa)%3B CAB88489.1|AL353816 putative two-component system response regulator from Streptomyces coelicolor (248 aa)%3B BJY09666_1 two-component response regulator (ragA%2C ragB and rpoH3) from B.japonicum (226 aa)%2C FASTA score: (43.8%25 identity in 224 aa overlap)%3B BSAJ2571_44 two-component response regulator from Bacillus subtilis (228 aa)%2C FASTA score: (46.4%25 identity in 224 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv1033c (257 aa)%3B Rv0903c (236 aa)%2C FASTA score: (50.7 identity in 225 aa overlap)%3B etc. Contains PS00217 Sugar transport proteins signature 2. Start changed since first submission (-2 aa). MprAB is involved in the regulation of genes in response to environmental stress (See He et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mprA;inference=protein motif:PROSITE:PS00217;locus_tag=Rv0981;product=Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein);protein_id=CCP43731.1;transl_table=11
AL123456.3	EMBL	gene	1097508	1099022	.	+	.	ID=gene-Rv0982;Name=mprB;gbkey=Gene;gene=mprB;gene_biotype=protein_coding;locus_tag=Rv0982
AL123456.3	EMBL	CDS	1097508	1099022	.	+	0	ID=cds-CCP43732.1;Parent=gene-Rv0982;Dbxref=EnsemblGenomes-Gn:Rv0982,EnsemblGenomes-Tr:CCP43732,GOA:P9WGL1,InterPro:IPR003594,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR009082,NCBI_GP:CCP43732.1;Name=CCP43732.1;Note=Rv0982%2C (MTV044.10)%2C len: 504 aa. MprB%2C two component sensor kinase%2C probable transmembrane protein (see citation below)%2C equivalent to AL035500|MLCL373_16|NP_301251.1|NC_002677 putative two-component system sensor kinase from Mycobacterium leprae (519 aa)%2C FASTA score: (81.0%25 identity in 521 aa overlap). Also highly similar to others (especially in C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221 sensor kinase from Corynebacterium glutamicum (455 aa)%3B CAB89748.1|AL354616 putative two-component histidine kinase from Streptomyces coelicolor (481 aa)%3B X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa)%2C FASTA scores: opt: 451%2C E(): 4.2e-21%2C (36.0%25 identity in 303 aa overlap)%3B P30847|BAES_ECOLI sensor protein from Escherichia coli (467 aa)%2C FASTA scores: opt: 412%2C E(): 1.3e-18%2C (30.4%25 identity in 336 aa overlap)%3B etc. Also similar in C-terminal region to C-terminus of Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis (446 aa)%2C FASTA scores: opt: 423%2C E(): 2.6e-19%2C (28.4 identity in 462 aa overlap). MprAB is involved in the regulation of genes in response to environmental stress (See He et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mprB;locus_tag=Rv0982;product=Two component sensor kinase MprB;protein_id=CCP43732.1;transl_table=11
AL123456.3	EMBL	gene	1099066	1100460	.	+	.	ID=gene-Rv0983;Name=pepD;gbkey=Gene;gene=pepD;gene_biotype=protein_coding;gene_synonym=mtb32b;locus_tag=Rv0983
AL123456.3	EMBL	CDS	1099066	1100460	.	+	0	ID=cds-CCP43733.1;Parent=gene-Rv0983;Dbxref=EnsemblGenomes-Gn:Rv0983,EnsemblGenomes-Tr:CCP43733,GOA:O53896,InterPro:IPR001478,InterPro:IPR001940,InterPro:IPR009003,PDB:1Y8T,PDB:2Z9I,UniProtKB/TrEMBL:O53896,NCBI_GP:CCP43733.1;Name=CCP43733.1;Note=Rv0983%2C (MTV044.11)%2C len: 464 aa. Probable pepD (alternate gene name: mtb32b)%2C secreted or membrane serine protease (see citation below)%2C equivalent (but longer 18 aa in N-terminus) to AL035500|MLCL373_17|T45448 probable serine proteinase from Mycobacterium leprae (452 aa)%2C FASTA score: (74.2%25 identity in 466 aa overlap)%3B and highly similar to others from Mycobacterium leprae. Also highly similar (except in N-terminus) to other proteases e.g. CAC01350.1|AL390975 putative protease from Streptomyces coelicolor (542 aa)%3B NP_440705.1|NC_000911|HtrA serine protease from Synechocystis sp. (452 aa)%3B NP_346646.1|NC_003028 serine protease from Streptococcus pneumoniae (393 aa)%3B etc. Also similar in part to members of the htrA-antigen family e.g. U87242|MTU87242_3|HtrA serine protease from M. tuberculosis (542 aa)%2C FASTA scores: opt: 846%2C E(): 2e-28%2C (40.6%25 identity in 392 aa overlap)%3B and similar to other hypothetical serine proteases e.g. Rv0983%2C Rv0125%2C etc. Belongs to the serine protease family. Conserved in M. tuberculosis%2C M. leprae%2CM. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepD;locus_tag=Rv0983;product=Probable serine protease PepD (serine proteinase) (MTB32B);protein_id=CCP43733.1;transl_table=11
AL123456.3	EMBL	gene	1100460	1101005	.	+	.	ID=gene-Rv0984;Name=moaB2;gbkey=Gene;gene=moaB2;gene_biotype=protein_coding;locus_tag=Rv0984
AL123456.3	EMBL	CDS	1100460	1101005	.	+	0	ID=cds-CCP43734.1;Parent=gene-Rv0984;Dbxref=EnsemblGenomes-Gn:Rv0984,EnsemblGenomes-Tr:CCP43734,GOA:O53897,InterPro:IPR001453,InterPro:IPR020817,UniProtKB/TrEMBL:O53897,NCBI_GP:CCP43734.1;Name=CCP43734.1;Note=Rv0984%2C (MTV044.12)%2C len: 181 aa. Possible moaB2%2Cpterin-4-alpha-carbinolamine dehydratase%2C highly similar to NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa)%2CFASTA score: (92.3%25 identity in 181 aa overlap). Also similar to others e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa)%3B Q56208|MOCB_SYNP7 molybdenum cofactor biosynthesis protein CB from Synechococcus sp. (319 aa)%2CFASTA score: (37.3%25 identity in 142 aa overlap)%3B C-terminus of NP_197599.1|NC_003076 molybdopterin biosynthesis CNX1 protein from Arabidopsis thaliana (670 aa)%3B etc. Also similar to Rv0865|MOG from Mycobacterium tuberculosis (160 aa)%3B and other mog proteins e.g. CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa). Could belong to the pterin-4-alpha-carbinolamine dehydratase family. Alternative start codon has been suggested in position 1100508.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moaB2;locus_tag=Rv0984;product=Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD);protein_id=CCP43734.1;transl_table=11
AL123456.3	EMBL	gene	1101025	1101480	.	-	.	ID=gene-Rv0985c;Name=mscL;gbkey=Gene;gene=mscL;gene_biotype=protein_coding;locus_tag=Rv0985c
AL123456.3	EMBL	CDS	1101025	1101480	.	-	0	ID=cds-CCP43735.1;Parent=gene-Rv0985c;Dbxref=EnsemblGenomes-Gn:Rv0985c,EnsemblGenomes-Tr:CCP43735,GOA:P9WJN5,InterPro:IPR001185,InterPro:IPR019823,InterPro:IPR029027,NCBI_GP:CCP43735.1;Name=CCP43735.1;Note=Rv0985c%2C (MTV044.13c)%2C len: 151 aa. Possible mscL%2Clarge conductance mechanosensitive ion channel (integral membrane protein) (see citations below%2C equivalent to AL035500|MLCL373_19|NP_301254.1|NC_002677 putative mechanosensitive channel protein from Mycobacterium leprae (154 aa)%2C FASTA score: (71.0%25 identity in 155 aa overlap). Also highly similar to others e.g. NP_268999.1|NC_002737 putative large conductance mechanosensitive channel from Streptococcus pyogenes (120 aa)%3B CAB90974.1|AL355832 putative mechanosensitive channel from Streptomyces coelicolor (156 aa)%3B Q9X722|MSCL_CLOHI large-conductance mechanosensitive channel from Clostridium histolyticum (133 aa)%3B Z83337|BSZ83337_6 large conductance mechanosensitive channel from Bacillus subtilis (130 aa)%2C FASTA scores: opt: 248%2C E(): 8.4e-10%2C (39.0%25 identity in 136 aa overlap)%3B U08371|ECU08371_1 large conductance mechanosensitive channel from Escherichia coli strain K-12 (136 aa)%2C FASTA score: (36.6%25 identity in 134 aa overlap)%3B etc. Belongs to the MscL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mscL;locus_tag=Rv0985c;product=Possible large-conductance ion mechanosensitive channel MscL;protein_id=CCP43735.1;transl_table=11
AL123456.3	EMBL	gene	1101803	1102549	.	+	.	ID=gene-Rv0986;Name=Rv0986;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0986
AL123456.3	EMBL	CDS	1101803	1102549	.	+	0	ID=cds-CCP43736.1;Parent=gene-Rv0986;Dbxref=EnsemblGenomes-Gn:Rv0986,EnsemblGenomes-Tr:CCP43736,GOA:P9WQK1,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP43736.1;Name=CCP43736.1;Note=Rv0986%2C (MTV044.14)%2C len: 248 aa. Probable ATP-binding protein ABC transporter supposedly involved in transport of adhesion component (see citation below)%2Chighly similar to many ATP-binding proteins e.g. AE0010|AE001033_8 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (228 aa)%2C FASTA scores: opt: 669%2CE(): 0%2C (45.7%25 identity in 219 aa overlap)%3B CAB81857.1|AL161691 putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa)%3B X84019|ZMDNAGRP_4 glutamate uptake regulatory protein (grp) from Z.mobilis (232 aa)%2C FASTA score: (44.4%25 identity in 225 aa overlap)%3B Z99111|BSUB0008_108 from Bacillus subtilis (230 aa)%2C FASTA score: (38.7%25 identity in 222 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters). Believed to have been acquired by horizontal gene transfer (See Rosas-Magallanes et el.%2C 2006%3B Becq et al.%2C 2007).;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv0986;product=Probable adhesion component transport ATP-binding protein ABC transporter;protein_id=CCP43736.1;transl_table=11
AL123456.3	EMBL	gene	1102542	1105109	.	+	.	ID=gene-Rv0987;Name=Rv0987;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0987
AL123456.3	EMBL	CDS	1102542	1105109	.	+	0	ID=cds-CCP43737.1;Parent=gene-Rv0987;Dbxref=EnsemblGenomes-Gn:Rv0987,EnsemblGenomes-Tr:CCP43737,GOA:O53900,InterPro:IPR003838,InterPro:IPR025857,UniProtKB/TrEMBL:O53900,NCBI_GP:CCP43737.1;Name=CCP43737.1;Note=Rv0987%2C (MTV044.15%2C MTCI237.01)%2C len: 855 aa. Probable transmembrane protein ABC transporter supposedly involved in transport of adhesion component (see citation below)%2C whose N-terminus shows similarity with hypothetical proteins%2C generally transmembrane proteins%2C e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa)%3B P44252|YCFU_HAEIN|HI1555 hypothetical protein from Haemophilus influenzae (393 aa)%2C FASTA scores: opt: 265%2CE(): 1.7e-09%2C (23.6%25 identity in 402 aa overlap)%3B etc. N-and C-termini respectively show similarity to O32735 ATTF protein (420 aa)%2C FASTA scores: E(): 1e-09%2C (26.7%25 identity in 430 aa overlap)%2C and G2340078 ATTG protein (359 aa)%2CFASTA scores: E(): 2.7e-08%2C (27.8%25 identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Believed to have been acquired by horizontal gene transfer (See Rosas-Magallanes et el.%2C 2006%3B Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv0987;product=Probable adhesion component transport transmembrane protein ABC transporter;protein_id=CCP43737.1;transl_table=11
AL123456.3	EMBL	gene	1105116	1106276	.	+	.	ID=gene-Rv0988;Name=Rv0988;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0988
AL123456.3	EMBL	CDS	1105116	1106276	.	+	0	ID=cds-CCP43738.1;Parent=gene-Rv0988;Dbxref=EnsemblGenomes-Gn:Rv0988,EnsemblGenomes-Tr:CCP43738,GOA:O86370,InterPro:IPR010791,InterPro:IPR023374,UniProtKB/TrEMBL:O86370,NCBI_GP:CCP43738.1;Name=CCP43738.1;Note=Rv0988%2C (MTCI237.02)%2C len: 386 aa. Possible conserved exported protein%2C with potential N-terminal signal sequence%2C similar (except in N-terminus) to O32737|L63540 ATTH protein from Agrobacterium tumefaciens (355 aa)%2C FASTA scores: opt: 651%2C E(): 5.7e-33%2C (33.4%25 identity in 344 aa overlap)%3B and NP_231265.1|NC_002505 conserved hypothetical protein from Vibrio cholerae (372 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008). Believed to have been acquired by horizontal gene transfer (See Rosas-Magallanes et el.%2C 2006%3B Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0988;product=Possible conserved exported protein;protein_id=CCP43738.1;transl_table=11
AL123456.3	EMBL	gene	1106405	1107382	.	-	.	ID=gene-Rv0989c;Name=grcC2;gbkey=Gene;gene=grcC2;gene_biotype=protein_coding;locus_tag=Rv0989c
AL123456.3	EMBL	CDS	1106405	1107382	.	-	0	ID=cds-CCP43739.1;Parent=gene-Rv0989c;Dbxref=EnsemblGenomes-Gn:Rv0989c,EnsemblGenomes-Tr:CCP43739,GOA:O05572,InterPro:IPR000092,InterPro:IPR008949,InterPro:IPR017446,UniProtKB/TrEMBL:O05572,NCBI_GP:CCP43739.1;Name=CCP43739.1;Note=Rv0989c%2C (MTCI237.03c)%2C len: 325 aa. Probable grcC2%2Cpolyprenyl diphosphate synthetase%2C highly similar to NP_302483.1|NC_002677 polyprenyl diphosphate synthase component from Mycobacterium leprae (330 aa). Also similar to others (generally hepta or hexaprenyl e.g. NP_471378.1|NC_003212 protein similar to heptaprenyl diphosphate synthase component II (menaquinone biosynthesis) from Listeria innocua (321 aa)%3B NP_371994.1|NC_002758 heptaprenyl diphosphate syntase component II from Staphylococcus aureus subsp. aureus Mu50 (319 aa)%3B P55785|HEP2_BACST heptaprenyl diphosphate synthase component from Bacillus subtilis (323 aa)%2C FASTA scores: opt: 496%2C E(): 1.4e-24%2C (31.4%25 identity in 306 aa overlap)%3B etc. Also highly similar to Mycobacterium tuberculosis proteins e.g. Rv0562|grcC1|NP_215076.1|MTCY25D10.41 probable polyprenyl-diphosphate synthase (335 aa)%3B Rv3383%2C Rv3398c%2CRv2173%2C etc. Seems to belong to the FPP/GGPP synthetases family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=grcC2;locus_tag=Rv0989c;product=Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase);protein_id=CCP43739.1;transl_table=11
AL123456.3	EMBL	gene	1107443	1108099	.	-	.	ID=gene-Rv0990c;Name=Rv0990c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0990c
AL123456.3	EMBL	CDS	1107443	1108099	.	-	0	ID=cds-CCP43740.1;Parent=gene-Rv0990c;Dbxref=EnsemblGenomes-Gn:Rv0990c,EnsemblGenomes-Tr:CCP43740,InterPro:IPR013974,UniProtKB/TrEMBL:O05573,NCBI_GP:CCP43740.1;Name=CCP43740.1;Note=Rv0990c%2C (MTCI237.04c)%2C len: 218 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv0990c;product=Hypothetical protein;protein_id=CCP43740.1;transl_table=11
AL123456.3	EMBL	gene	1108172	1108504	.	-	.	ID=gene-Rv0991c;Name=Rv0991c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0991c
AL123456.3	EMBL	CDS	1108172	1108504	.	-	0	ID=cds-CCP43741.1;Parent=gene-Rv0991c;Dbxref=EnsemblGenomes-Gn:Rv0991c,EnsemblGenomes-Tr:CCP43741,InterPro:IPR013429,UniProtKB/TrEMBL:O05574,NCBI_GP:CCP43741.1;Name=CCP43741.1;Note=Rv0991c%2C (MTCI237.05c)%2C len: 110 aa. Conserved ser-rich protein (especially in C-terminus)%2C highly similar to N-terminus of NP_301255.1|NC_002677 conserved hypothetical protein (Ser-rich C-terminus) from Mycobacterium leprae (99 aa). Also highly similar to SCE22.04|AB90971.1|AL355832 hypothetical protein from Streptomyces coelicolor (110 aa)%3B and similar to others.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0991c;product=Conserved serine rich protein;protein_id=CCP43741.1;transl_table=11
AL123456.3	EMBL	gene	1108578	1109171	.	-	.	ID=gene-Rv0992c;Name=Rv0992c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0992c
AL123456.3	EMBL	CDS	1108578	1109171	.	-	0	ID=cds-CCP43742.1;Parent=gene-Rv0992c;Dbxref=EnsemblGenomes-Gn:Rv0992c,EnsemblGenomes-Tr:CCP43742,GOA:O05575,InterPro:IPR002698,InterPro:IPR024185,UniProtKB/TrEMBL:O05575,NCBI_GP:CCP43742.1;Name=CCP43742.1;Note=Rv0992c%2C (MTCI237.06c)%2C len: 197 aa. Conserved hypothetical protein%2C equivalent to NP_301256.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (197 aa). Also similar%2C except in N-terminus%2C to other hypothetical proteins and ligases e.g. SCE87.34|CAB59679.1|AL132674 hypothetical protein from Streptomyces coelicolor (204 aa)%3B NP_461977.1|NC_003197 putative ligase from Salmonella typhimurium (182 aa)%3B P09160|YGFA_ECOLI hypothetical 21.1 kDa protein from Escherichia coli (182 aa)%2C FASTA scores: opt: 191%2C E(): 1.1e-09%2C (29.5%25 identity in 146 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0992c;product=Conserved hypothetical protein;protein_id=CCP43742.1;transl_table=11
AL123456.3	EMBL	gene	1109272	1110192	.	+	.	ID=gene-Rv0993;Name=galU;gbkey=Gene;gene=galU;gene_biotype=protein_coding;locus_tag=Rv0993
AL123456.3	EMBL	CDS	1109272	1110192	.	+	0	ID=cds-CCP43743.1;Parent=gene-Rv0993;Dbxref=EnsemblGenomes-Gn:Rv0993,EnsemblGenomes-Tr:CCP43743,GOA:O05576,InterPro:IPR005835,InterPro:IPR029044,UniProtKB/TrEMBL:O05576,NCBI_GP:CCP43743.1;Name=CCP43743.1;Note=Rv0993%2C (MTCI237.07)%2C len: 306 aa. GalU%2CUTP--glucose-1-phosphate uridylyltransferase%2C equivalent to AL035500|MLCL373_22 putative UTP-glucose-1-phosphate uridylyltransferase from Mycobacterium leprae (306 aa)%2CFASTA score: (89.7%25 identity in 302 aa overlap). Also highly similar to others e.g. AB59678.1|AL132674 UTP-glucose-1-phosphate uridylyltransferase from Streptomyces coelicolor (303 aa)%3B NP_244519.1|NC_002570 UTP-glucose-1-phosphate uridylyltransferase from Bacillus halodurans (297 aa)%3B P25520|GALU_ECOLI|B1236|Z2012|ECS17 UTP--glucose-1-phosphate uridylyltransferase from Escherichia coli strains K12 and O157:H7 (301 aa)%2C FASTA scores: opt: 624%2C E(): 2.4e-33%2C (38.8%25 identity in 299 aa overlap)%3B etc. Belongs to the prokaryotic UDPGP family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=galU;locus_tag=Rv0993;product=UTP--glucose-1-phosphate uridylyltransferase GalU (UDP-glucose pyrophosphorylase) (UDPGP) (alpha-D-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase);protein_id=CCP43743.1;transl_table=11
AL123456.3	EMBL	gene	1110269	1111549	.	+	.	ID=gene-Rv0994;Name=moeA1;gbkey=Gene;gene=moeA1;gene_biotype=protein_coding;gene_synonym=moeA;locus_tag=Rv0994
AL123456.3	EMBL	CDS	1110269	1111549	.	+	0	ID=cds-CCP43744.1;Parent=gene-Rv0994;Dbxref=EnsemblGenomes-Gn:Rv0994,EnsemblGenomes-Tr:CCP43744,GOA:P9WJQ7,InterPro:IPR001453,InterPro:IPR005110,InterPro:IPR005111,InterPro:IPR020817,NCBI_GP:CCP43744.1;Name=CCP43744.1;Note=Rv0994%2C (MTCI237.08)%2C len: 426 aa. Probable moeA1%2Cmolybdenum cofactor biosynthesis protein%2C equivalent to AL035500|MLCL373_23 putative molybdopterin biosynthesis protein from Mycobacterium leprae (424 aa)%2C FASTA score: (88.3%25 identity in 426 aa overlap). Also highly similar to many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis protein from Streptomyces coelicolor (424 aa)%3B NP_385769.1|NC_003047 probable molybdopterin biosynthesis protein from Sinorhizobium meliloti (406 aa)%3B P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein from Escherichia coli (411 aa)%2C FASTA scores: opt: 519%2CE(): 1.3e-24%2C (32.3%25 identity in 402 aa overlap)%3B etc. Also similar to MOEA2|Rv0438c|MTV037.02c probable molybdopterin biosynthesis protein from Mycobacterium tuberculosis (405 aa). Note that previously known as moeA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moeA1;locus_tag=Rv0994;product=Probable molybdopterin biosynthesis protein MoeA1;protein_id=CCP43744.1;transl_table=11
AL123456.3	EMBL	gene	1111612	1112223	.	+	.	ID=gene-Rv0995;Name=rimJ;gbkey=Gene;gene=rimJ;gene_biotype=protein_coding;locus_tag=Rv0995
AL123456.3	EMBL	CDS	1111612	1112223	.	+	0	ID=cds-CCP43745.1;Parent=gene-Rv0995;Dbxref=EnsemblGenomes-Gn:Rv0995,EnsemblGenomes-Tr:CCP43745,GOA:O05578,InterPro:IPR000182,InterPro:IPR016181,UniProtKB/TrEMBL:O05578,NCBI_GP:CCP43745.1;Name=CCP43745.1;Note=Rv0995%2C (MTCI237.09)%2C len: 203 aa. RimJ%2Cribosomal-protein-alanine acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Equivalent to AL035500|MLCL373_24 probable acyltransferase from Mycobacterium leprae (218 aa)%2C FASTA scores: (86.0%25 identity in 200 aa overlap). Also similar to others and many acyltransferases e.g. BAB69252.1|AB070946 possible acyltransferase from Streptomyces avermitilis (156 aa)%3B NP_385025.1|NC_003047 probable ribosomal-protein-alanine acetyltransferase from Sinorhizobium meliloti (203 aa)%3B P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444 ribosomal-protein-alanine acetyltransferase from Escherichia coli strains K12 and O157:H7 (194 aa)%2C FASTA scores: opt: 247%2C E(): 1.5e-10%2C (26.9%25 identity in 186 aa overlap). Belongs to the acetyltransferase family%2C RIMJ subfamily.;gbkey=CDS;gene=rimJ;locus_tag=Rv0995;product=Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5);protein_id=CCP43745.1;transl_table=11
AL123456.3	EMBL	gene	1112384	1113460	.	+	.	ID=gene-Rv0996;Name=Rv0996;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0996
AL123456.3	EMBL	CDS	1112384	1113460	.	+	0	ID=cds-CCP43746.1;Parent=gene-Rv0996;Dbxref=EnsemblGenomes-Gn:Rv0996,EnsemblGenomes-Tr:CCP43746,GOA:O05579,UniProtKB/TrEMBL:O05579,NCBI_GP:CCP43746.1;Name=CCP43746.1;Note=Rv0996%2C (MTCI237.10)%2C len: 358 aa. Probable conserved transmembrane protein%2C equivalent to AL035500|MLCL373_25 putative membrane protein from Mycobacterium leprae (342 aa)%2C FASTA scores: (66.4%25 identity in 360 aa overlap). Contains possible signal sequence and other hydrophobic domains. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0996;product=Probable conserved transmembrane protein;protein_id=CCP43746.1;transl_table=11
AL123456.3	EMBL	gene	1113511	1113583	.	+	.	ID=gene-alaV;Name=alaV;gbkey=Gene;gene=alaV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1113511	1113583	.	+	.	ID=rna-alaV;Parent=gene-alaV;Note=codon recognized: GCG%3B alaV%2C tRNA-Ala%2C anticodon cgc%2C length %3D 73;anticodon=(pos:1113544..1113546);gbkey=tRNA;gene=alaV;product=tRNA-Ala
AL123456.3	EMBL	exon	1113511	1113583	.	+	.	ID=exon-alaV-1;Parent=rna-alaV;Note=codon recognized: GCG%3B alaV%2C tRNA-Ala%2C anticodon cgc%2C length %3D 73;anticodon=(pos:1113544..1113546);gbkey=tRNA;gene=alaV;product=tRNA-Ala
AL123456.3	EMBL	gene	1114293	1114724	.	+	.	ID=gene-Rv0997;Name=Rv0997;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0997
AL123456.3	EMBL	CDS	1114293	1114724	.	+	0	ID=cds-CCP43747.1;Parent=gene-Rv0997;Dbxref=EnsemblGenomes-Gn:Rv0997,EnsemblGenomes-Tr:CCP43747,UniProtKB/TrEMBL:O05580,NCBI_GP:CCP43747.1;Name=CCP43747.1;Note=Rv0997%2C (MTCI237.11)%2C len: 143 aa. Hypothetical unknown protein%2C equivalent to AAK45276.1 from Mycobacterium tuberculosis strain CDC1551 (87 aa) but longer 56 aa.;gbkey=CDS;locus_tag=Rv0997;product=Hypothetical protein;protein_id=CCP43747.1;transl_table=11
AL123456.3	EMBL	gene	1114748	1115749	.	+	.	ID=gene-Rv0998;Name=Rv0998;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0998
AL123456.3	EMBL	CDS	1114748	1115749	.	+	0	ID=cds-CCP43748.1;Parent=gene-Rv0998;Dbxref=EnsemblGenomes-Gn:Rv0998,EnsemblGenomes-Tr:CCP43748,GOA:O05581,InterPro:IPR000182,InterPro:IPR000595,InterPro:IPR014710,InterPro:IPR016181,InterPro:IPR018488,InterPro:IPR018490,PDB:4AVA,PDB:4AVB,PDB:4AVC,NCBI_GP:CCP43748.1;Name=CCP43748.1;Note=Rv0998%2C (MTCI237.12)%2C len: 333 aa. Conserved hypothetical protein%2C with cyclic nucleotide-binding domain in N-terminal part and GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005. Possibly cyclic nucleotide-dependent protein kinase%2C highly similar to NP_301261.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (353 aa)%3B and AL035500|MLCL373.38|T45457 hypothetical protein from Mycobacterium leprae (143 aa)%2C FASTA score: (61.5%25 identity in 143 aa overlap). Also similar to many hypothetical proteins and cyclic-NMP-dependent protein kinases (generally at C-terminus) e.g. N-terminus of SC9B10.09|T35878 hypothetical protein from Streptomyces coelicolor (1039 aa)%3B P05987|KAPR_DICDI camp-dependent protein kinase regulatory chain from Dictyostelium discoideum (327 aa)%2C FASTA scores: opt: 177%2C E(): 0.00036%2C(32.0%25 identity in 122 aa overlap)%3B NP_104403.1|NC_002678 hypothetical protein (contains similarity to cAMP-dependent protein kinase regulatory subunit) from Mesorhizobium loti (151 aa)%3B etc. Contains PS00889 Cyclic nucleotide-binding domain signature 2. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;inference=protein motif:PROSITE:PS00889;locus_tag=Rv0998;product=Conserved hypothetical protein;protein_id=CCP43748.1;transl_table=11
AL123456.3	EMBL	gene	1115767	1116525	.	+	.	ID=gene-Rv0999;Name=Rv0999;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv0999
AL123456.3	EMBL	CDS	1115767	1116525	.	+	0	ID=cds-CCP43749.1;Parent=gene-Rv0999;Dbxref=EnsemblGenomes-Gn:Rv0999,EnsemblGenomes-Tr:CCP43749,GOA:O05582,UniProtKB/TrEMBL:O05582,NCBI_GP:CCP43749.1;Name=CCP43749.1;Note=Rv0999%2C (MTCI237.13)%2C len: 252 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv0999;product=Unknown protein;protein_id=CCP43749.1;transl_table=11
AL123456.3	EMBL	gene	1116531	1117148	.	-	.	ID=gene-Rv1000c;Name=Rv1000c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1000c
AL123456.3	EMBL	CDS	1116531	1117148	.	-	0	ID=cds-CCP43750.1;Parent=gene-Rv1000c;Dbxref=EnsemblGenomes-Gn:Rv1000c,EnsemblGenomes-Tr:CCP43750,GOA:L7N6A4,InterPro:IPR005123,InterPro:IPR027450,UniProtKB/TrEMBL:L7N6A4,NCBI_GP:CCP43750.1;Name=CCP43750.1;Note=Rv1000c%2C len: 205 aa. Conserved hypothetical protein%2C equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from Streptomyces coelicolor (210 aa)%2C FASTA scores: E(): 2.1e-45%2C (56.8%25 identity)%3B 9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488 protein described as DNA repair system specific for alkylated DNA from Xylella fastidiosa (200 aa)%2C FASTA scores: E(): 3.4e-14%2C (38.55%25 identity)%3B and similar in C-terminus to other hypothetical proteins. Note that replaces original Rv1000 predicted on other strand.;gbkey=CDS;locus_tag=Rv1000c;product=Conserved hypothetical protein;protein_id=CCP43750.1;transl_table=11
AL123456.3	EMBL	gene	1117185	1118393	.	+	.	ID=gene-Rv1001;Name=arcA;gbkey=Gene;gene=arcA;gene_biotype=protein_coding;locus_tag=Rv1001
AL123456.3	EMBL	CDS	1117185	1118393	.	+	0	ID=cds-CCP43751.1;Parent=gene-Rv1001;Dbxref=EnsemblGenomes-Gn:Rv1001,EnsemblGenomes-Tr:CCP43751,GOA:P9WQ05,InterPro:IPR003198,InterPro:IPR003876,NCBI_GP:CCP43751.1;Name=CCP43751.1;Note=Rv1001%2C (MTCI237.16)%2C len: 402 aa. Probable arcA%2Carginine deiminase%2C similar to e.g. ARCA_PSEAE|P13981 arginine deiminase (417 aa)%2C fasta scores: opt: 581%2C E(): 1.4e-31%2C (39.4%25 identity in 411 aa overlap)%3B also similar to SAGP_STRPY|P16962 streptococcal acid glycoprotein (410 aa)%2C FASTA scores%2C opt: 823%2C E():0%2C (38.3%25 identity in 402 aa overlap). Belongs to the arginine deiminase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=arcA;locus_tag=Rv1001;product=Probable arginine deiminase ArcA (adi) (ad) (arginine dihydrolase);protein_id=CCP43751.1;transl_table=11
AL123456.3	EMBL	gene	1118428	1119939	.	-	.	ID=gene-Rv1002c;Name=Rv1002c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1002c
AL123456.3	EMBL	CDS	1118428	1119939	.	-	0	ID=cds-CCP43752.1;Parent=gene-Rv1002c;Dbxref=EnsemblGenomes-Gn:Rv1002c,EnsemblGenomes-Tr:CCP43752,GOA:P9WN05,InterPro:IPR003342,InterPro:IPR027005,NCBI_GP:CCP43752.1;Name=CCP43752.1;Note=Rv1002c%2C (MTCI237.17c)%2C len: 503 aa. Conserved membrane protein. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Similar to AL132674|SCE87.05 hypothetical protein from Streptomyces coelicolor (591 aa)%2C FASTA scores: opt: 666%2CE(): 0%2C (39.0%25 identity in 546 aa overlap)%3B weakly similar and to TSCC_PSEAM|P55019 thiazide-sensitive sodium-chloride cotransporter from Pseudopleuronectes americanus (1023 aa)%2CFASTA scores: opt: 44%2C E(): 4.2e-06%2C (22.4%25 identity in 326 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1002c;product=Conserved membrane protein;protein_id=CCP43752.1;transl_table=11
AL123456.3	EMBL	gene	1120022	1120879	.	+	.	ID=gene-Rv1003;Name=Rv1003;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1003
AL123456.3	EMBL	CDS	1120022	1120879	.	+	0	ID=cds-CCP43753.1;Parent=gene-Rv1003;Dbxref=EnsemblGenomes-Gn:Rv1003,EnsemblGenomes-Tr:CCP43753,GOA:P9WGW7,InterPro:IPR000878,InterPro:IPR008189,InterPro:IPR014776,InterPro:IPR014777,InterPro:IPR018063,NCBI_GP:CCP43753.1;Name=CCP43753.1;Note=Rv1003%2C (MTCI237.19)%2C len: 285 aa. Conserved protein%2C similar to others e.g. AL132674|SCE87.04 Streptomyces coelicolor (286 aa)%2C FASTA scores: opt: 877%2CE(): 0%2C (53.2%25 identity in 280 aa overlap)%3B and YRAL_ECOLI|P45528 hypothetical 31.3 kd protein (286 aa)%2CFASTA scores: opt: 561%2C E(): 4.4e-27%2C (36.9%25 identity in 279 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1003;product=Conserved protein;protein_id=CCP43753.1;transl_table=11
AL123456.3	EMBL	gene	1120889	1122148	.	-	.	ID=gene-Rv1004c;Name=Rv1004c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1004c
AL123456.3	EMBL	CDS	1120889	1122148	.	-	0	ID=cds-CCP43754.1;Parent=gene-Rv1004c;Dbxref=EnsemblGenomes-Gn:Rv1004c,EnsemblGenomes-Tr:CCP43754,GOA:O05589,UniProtKB/TrEMBL:O05589,NCBI_GP:CCP43754.1;Name=CCP43754.1;Note=Rv1004c%2C (MTCI237.20c)%2C len: 419 aa. Probable membrane protein. Contains repetitive sequences%2C which have similarities with elastin%2C and possible N-terminal signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1004c;product=Probable membrane protein;protein_id=CCP43754.1;transl_table=11
AL123456.3	EMBL	gene	1122222	1123598	.	-	.	ID=gene-Rv1005c;Name=pabB;gbkey=Gene;gene=pabB;gene_biotype=protein_coding;locus_tag=Rv1005c
AL123456.3	EMBL	CDS	1122222	1123598	.	-	0	ID=cds-CCP43755.1;Parent=gene-Rv1005c;Dbxref=EnsemblGenomes-Gn:Rv1005c,EnsemblGenomes-Tr:CCP43755,GOA:O05591,InterPro:IPR005801,InterPro:IPR005802,InterPro:IPR015890,InterPro:IPR019999,UniProtKB/TrEMBL:O05591,NCBI_GP:CCP43755.1;Name=CCP43755.1;Note=Rv1005c%2C (MTCI237.22c)%2C len: 458 aa (Start-site not certain). Probable PabD%2C para-aminobenzoate synthase component I. Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase component I from Escherichia coli (453 aa)%2C FASTA scores: opt: 589%2C E(): 1.8e-27%2C (40.7%25 identity in 268 aa overlap). Similar to M. tuberculosis Rv1609%2C Rv3215%2C Rv2386c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pabB;locus_tag=Rv1005c;product=Probable para-aminobenzoate synthase component I PABD;protein_id=CCP43755.1;transl_table=11
AL123456.3	EMBL	gene	1123714	1125417	.	+	.	ID=gene-Rv1006;Name=Rv1006;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1006
AL123456.3	EMBL	CDS	1123714	1125417	.	+	0	ID=cds-CCP43756.1;Parent=gene-Rv1006;Dbxref=EnsemblGenomes-Gn:Rv1006,EnsemblGenomes-Tr:CCP43756,GOA:O05592,InterPro:IPR017853,UniProtKB/TrEMBL:O05592,NCBI_GP:CCP43756.1;Name=CCP43756.1;Note=Rv1006%2C (MTCI237.23)%2C len: 567 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1006;product=Unknown protein;protein_id=CCP43756.1;transl_table=11
AL123456.3	EMBL	gene	1125444	1127003	.	-	.	ID=gene-Rv1007c;Name=metS;gbkey=Gene;gene=metS;gene_biotype=protein_coding;locus_tag=Rv1007c
AL123456.3	EMBL	CDS	1125444	1127003	.	-	0	ID=cds-CCP43757.1;Parent=gene-Rv1007c;Dbxref=EnsemblGenomes-Gn:Rv1007c,EnsemblGenomes-Tr:CCP43757,GOA:P9WFU5,InterPro:IPR001412,InterPro:IPR009080,InterPro:IPR014729,InterPro:IPR014758,InterPro:IPR015413,InterPro:IPR023457,NCBI_GP:CCP43757.1;Name=CCP43757.1;Note=Rv1007c%2C (MTCI237.24)%2C len: 519 aa. metS (MetG)%2Cmethionyl-tRNA synthetase%2C similar to many e.g. SYM_BACSU|P37465 methionyl-tRNA synthetase from Bacillus subtilus (664 aa)%2C FASTA scores: opt: 1506%2C E(): 0%2C (44.9%25 identity in 492 aa overlap)%3B similar to other Mycobacterium tuberculosis tRNA synthases e.g. Rv2448c%2C Rv1536%2C Rv0041. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family. Strong%2C to cysteinyl-tRNA synthetase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metS;inference=protein motif:PROSITE:PS00178;locus_tag=Rv1007c;product=Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase);protein_id=CCP43757.1;transl_table=11
AL123456.3	EMBL	gene	1127089	1127883	.	+	.	ID=gene-Rv1008;Name=tatD;gbkey=Gene;gene=tatD;gene_biotype=protein_coding;gene_synonym=yjjV;locus_tag=Rv1008
AL123456.3	EMBL	CDS	1127089	1127883	.	+	0	ID=cds-CCP43758.1;Parent=gene-Rv1008;Dbxref=EnsemblGenomes-Gn:Rv1008,EnsemblGenomes-Tr:CCP43758,GOA:O08343,InterPro:IPR001130,InterPro:IPR015991,InterPro:IPR018228,UniProtKB/TrEMBL:O08343,NCBI_GP:CCP43758.1;Name=CCP43758.1;Note=Rv1008%2C (MTCI237.25)%2C len: 264 aa. Probable tatD (alternate gene name: yjjV)%2C deoxyribonuclease%2C component of twin arginine translocation protein export system (see citations below). Similar to many members of the YBL055C/YJJV family e.g. YCFH_ECOLI|P37346 Putative deoxyribonuclease ycfH (265 aa)%2C fasta scores: opt: 487%2CE(): 1.4e-24%2C (36.7%25 identity in 270 aa overlap). Also similar to P37545|YABD_BACSU Putative deoxyribonuclease yabD (255 aa)%2C FASTA scores: opt: 599%2C E(): 7.7e-33%2C (40.1%25 identity in 262 aa overlap). Contains PS01137 Hypothetical YBL055c/yjjV family signature 1%2C and PS01091 Hypothetical YBL055c/yjjV family signature 3.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tatD;inference=protein motif:PROSITE:PS01137;locus_tag=Rv1008;product=Probable deoxyribonuclease TatD (YJJV protein);protein_id=CCP43758.1;transl_table=11
AL123456.3	EMBL	gene	1128091	1129179	.	+	.	ID=gene-Rv1009;Name=rpfB;gbkey=Gene;gene=rpfB;gene_biotype=protein_coding;locus_tag=Rv1009
AL123456.3	EMBL	CDS	1128091	1129179	.	+	0	ID=cds-CCP43759.1;Parent=gene-Rv1009;Dbxref=EnsemblGenomes-Gn:Rv1009,EnsemblGenomes-Tr:CCP43759,GOA:P9WG29,InterPro:IPR007137,InterPro:IPR010618,InterPro:IPR011098,InterPro:IPR023346,PDB:1XSF,PDB:3EO5,PDB:4EMN,PDB:4KL7,PDB:4KPM,NCBI_GP:CCP43759.1;Name=CCP43759.1;Note=Rv1009%2C (MTCI237.26)%2C len: 362 aa. Probable rpfB%2Cresuscitation-promoting factor (see citation below)%2Csimilar to others from Mycobacterium tuberculosis: Rv2450c|MTV008.06c|RPFE probable resuscitation-promoting factor (172 aa)%2C FASTA scores: E(): 1.9e-19%2C (42.9%25 identity in 147 aa overlap)%3B Rv0867c|RPFA%2C Rv1884c|RPFC%2Cand Rv2389c|RPFD. Possible lipoprotein%3B contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Interacts with RipA (see Hett et al.%2C 2007). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpfB;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1009;product=Probable resuscitation-promoting factor RpfB;protein_id=CCP43759.1;transl_table=11
AL123456.3	EMBL	gene	1129152	1130105	.	+	.	ID=gene-Rv1010;Name=ksgA;gbkey=Gene;gene=ksgA;gene_biotype=protein_coding;locus_tag=Rv1010
AL123456.3	EMBL	CDS	1129152	1130105	.	+	0	ID=cds-CCP43760.1;Parent=gene-Rv1010;Dbxref=EnsemblGenomes-Gn:Rv1010,EnsemblGenomes-Tr:CCP43760,GOA:P9WH07,InterPro:IPR001737,InterPro:IPR011530,InterPro:IPR020596,InterPro:IPR020598,InterPro:IPR023165,InterPro:IPR029063,NCBI_GP:CCP43760.1;Name=CCP43760.1;Note=Rv1010%2C (MTCI237.27)%2C len: 317 aa. Probable ksgA%2Cdimethyladenosine transferase%2C similar to many e.g. KSGA_BACSU|P37468 dimethyladenosine transferase from Bacillus subtilus (292 aa)%2C FASTA scores: opt: 524%2C E(): 1.5e-28%2C (37.2%25 identity in 274 aa overlap)%3B similar to Mycobacterium tuberculosis hypothetical protein Rv1988. Contains PS01131 Ribosomal RNA adenine dimethylases signature.;gbkey=CDS;gene=ksgA;inference=protein motif:PROSITE:PS01131;locus_tag=Rv1010;product=Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N'%2C N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase);protein_id=CCP43760.1;transl_table=11
AL123456.3	EMBL	gene	1130191	1131111	.	+	.	ID=gene-Rv1011;Name=ispE;gbkey=Gene;gene=ispE;gene_biotype=protein_coding;locus_tag=Rv1011
AL123456.3	EMBL	CDS	1130191	1131111	.	+	0	ID=cds-CCP43761.1;Parent=gene-Rv1011;Dbxref=EnsemblGenomes-Gn:Rv1011,EnsemblGenomes-Tr:CCP43761,GOA:P9WKG7,InterPro:IPR004424,InterPro:IPR006204,InterPro:IPR013750,InterPro:IPR014721,InterPro:IPR020568,PDB:3PYD,PDB:3PYE,PDB:3PYF,PDB:3PYG,NCBI_GP:CCP43761.1;Name=CCP43761.1;Note=Rv1011%2C (MTCI237.28%2C MT1040)%2C len: 306 aa. Probable ispE%2C 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase %2Csimilar to others e.g. Q9K3R6|ISPE_STRCO Streptomyces coelicolor (299 aa)%2C FASTA scores: opt: 925%2C E(): 2.7e-49%2C(54.5%25 identity in 297 overlap)%3B etc. Belongs to the ISPE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ispE;locus_tag=Rv1011;product=Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase);protein_id=CCP43761.1;transl_table=11
AL123456.3	EMBL	gene	1131128	1131421	.	+	.	ID=gene-Rv1012;Name=Rv1012;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1012
AL123456.3	EMBL	CDS	1131128	1131421	.	+	0	ID=cds-CCP43762.1;Parent=gene-Rv1012;Dbxref=EnsemblGenomes-Gn:Rv1012,EnsemblGenomes-Tr:CCP43762,UniProtKB/TrEMBL:O05597,NCBI_GP:CCP43762.1;Name=CCP43762.1;Note=Rv1012%2C (MTCI237.29)%2C len: 97 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1012;product=Hypothetical protein;protein_id=CCP43762.1;transl_table=11
AL123456.3	EMBL	gene	1131625	1133259	.	+	.	ID=gene-Rv1013;Name=pks16;gbkey=Gene;gene=pks16;gene_biotype=protein_coding;locus_tag=Rv1013
AL123456.3	EMBL	CDS	1131625	1133259	.	+	0	ID=cds-CCP43763.1;Parent=gene-Rv1013;Dbxref=EnsemblGenomes-Gn:Rv1013,EnsemblGenomes-Tr:CCP43763,GOA:O05598,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR028154,NCBI_GP:CCP43763.1;Name=CCP43763.1;Note=Rv1013%2C (MTCI237.30-MTCY10G2.36c)%2C len: 544 aa. Putative pks16%2C polyketide synthase%2C similar to many e.g. N-terminus of Q50857|U24657 saframycin MX1 synthetase B (1770 aa)%2C FASTA scores: opt: 526%2C E(): 1.4e-25%2C (29.3%25 identity in 542 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks16;inference=protein motif:PROSITE:PS00455;locus_tag=Rv1013;product=Putative polyketide synthase Pks16;protein_id=CCP43763.1;transl_table=11
AL123456.3	EMBL	gene	1133333	1133908	.	-	.	ID=gene-Rv1014c;Name=pth;gbkey=Gene;gene=pth;gene_biotype=protein_coding;locus_tag=Rv1014c
AL123456.3	EMBL	CDS	1133333	1133908	.	-	0	ID=cds-CCP43764.1;Parent=gene-Rv1014c;Dbxref=EnsemblGenomes-Gn:Rv1014c,EnsemblGenomes-Tr:CCP43764,GOA:P9WHN7,InterPro:IPR001328,InterPro:IPR018171,PDB:2JRC,PDB:2Z2I,PDB:2Z2J,PDB:2Z2K,PDB:3TCK,PDB:3TCN,PDB:3TD2,PDB:3TD6,NCBI_GP:CCP43764.1;Name=CCP43764.1;Note=Rv1014c%2C (MTCY10G2.35)%2C len: 191 aa. Probable pth%2Cpeptidyl-tRNA hydrolase%2C similar to PTH_ECOLI|P23932 peptidy l-trna hydrolase from Escherichia coli (194 aa)%2CFASTA scores: opt: 472%2C E(): 2.3e-25%2C (39.6%25 identity in 187 aa overlap). Belongs to the PTH family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pth;locus_tag=Rv1014c;product=Probable peptidyl-tRNA hydrolase Pth;protein_id=CCP43764.1;transl_table=11
AL123456.3	EMBL	gene	1133921	1134568	.	-	.	ID=gene-Rv1015c;Name=rplY;gbkey=Gene;gene=rplY;gene_biotype=protein_coding;locus_tag=Rv1015c
AL123456.3	EMBL	CDS	1133921	1134568	.	-	0	ID=cds-CCP43765.1;Parent=gene-Rv1015c;Dbxref=EnsemblGenomes-Gn:Rv1015c,EnsemblGenomes-Tr:CCP43765,GOA:P9WHB5,InterPro:IPR001021,InterPro:IPR011035,InterPro:IPR020056,InterPro:IPR020057,InterPro:IPR029751,NCBI_GP:CCP43765.1;Name=CCP43765.1;Note=Rv1015c%2C (MTCY10G2.34)%2C len: 215 aa. rplY%2C 50s ribosomal protein L25%2C similar to RL25_ECOLI|P02426 50s ribosomal protein L25 from Escherichia coli (94 aa)%2C FASTA scores: opt: 182%2C E(): 2.5e-05%2C (38.4%25 identity in 86 aa overlap) and to CTC_BACSU|P14194 general stress protein from Bacillus subtilis (203 aa)%2C FASTA scores: opt: 260%2CE(): 1.4e-09%2C (28.4%25 identity in 201 aa overlap). Belongs to the L25P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplY;locus_tag=Rv1015c;product=50S ribosomal protein L25 RplY;protein_id=CCP43765.1;transl_table=11
AL123456.3	EMBL	gene	1134785	1135465	.	-	.	ID=gene-Rv1016c;Name=lpqT;gbkey=Gene;gene=lpqT;gene_biotype=protein_coding;locus_tag=Rv1016c
AL123456.3	EMBL	CDS	1134785	1135465	.	-	0	ID=cds-CCP43766.1;Parent=gene-Rv1016c;Dbxref=EnsemblGenomes-Gn:Rv1016c,EnsemblGenomes-Tr:CCP43766,GOA:P9WK59,InterPro:IPR019674,NCBI_GP:CCP43766.1;Name=CCP43766.1;Note=Rv1016c%2C (MTCY10G2.33)%2C len: 226 aa. Probable lpqT%2Cconserved lipoprotein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310 aa)%2C FASTA scores: opt: 329%2C E(): 2e-17%2C (32.3%25 identity in 229 aa overlap)%3B Rv0583c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqT;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1016c;product=Probable conserved lipoprotein LpqT;protein_id=CCP43766.1;transl_table=11
AL123456.3	EMBL	gene	1135501	1136481	.	-	.	ID=gene-Rv1017c;Name=prsA;gbkey=Gene;gene=prsA;gene_biotype=protein_coding;locus_tag=Rv1017c
AL123456.3	EMBL	CDS	1135501	1136481	.	-	0	ID=cds-CCP43767.1;Parent=gene-Rv1017c;Dbxref=EnsemblGenomes-Gn:Rv1017c,EnsemblGenomes-Tr:CCP43767,GOA:P9WKE3,InterPro:IPR000842,InterPro:IPR005946,InterPro:IPR029057,InterPro:IPR029099,NCBI_GP:CCP43767.1;Name=CCP43767.1;Note=Rv1017c%2C (MTCY10G2.32)%2C len: 326 aa. Probable prsA%2Cribose-phosphate pyrophosphokinase%2C highly similar to others e.g. KPRS_ECOLI|P08330 ribose-phosphate pyrophosphokinase from Escherichia coli (314 aa)%2C FASTA scores: opt: 826%2C E(): 0%2C (43.8%25 identity in 317 aa overlap). Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature%3B contains PS00144 Asparaginase / glutaminase active site signature 1. Belongs to the ribose-phosphate pyrophosphokinase family. Cofactor: both inorganic phosphate and magnesium ion are required for enzyme stability and activity (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prsA;inference=protein motif:PROSITE:PS00144;locus_tag=Rv1017c;product=Probable ribose-phosphate pyrophosphokinase PrsA (phosphoribosyl pyrophosphate synthetase) (PRPP synthetase);protein_id=CCP43767.1;transl_table=11
AL123456.3	EMBL	gene	1136573	1138060	.	-	.	ID=gene-Rv1018c;Name=glmU;gbkey=Gene;gene=glmU;gene_biotype=protein_coding;locus_tag=Rv1018c
AL123456.3	EMBL	CDS	1136573	1138060	.	-	0	ID=cds-CCP43768.1;Parent=gene-Rv1018c;Dbxref=EnsemblGenomes-Gn:Rv1018c,EnsemblGenomes-Tr:CCP43768,GOA:P9WMN3,InterPro:IPR001451,InterPro:IPR005882,InterPro:IPR011004,InterPro:IPR025877,InterPro:IPR029044,PDB:2QKX,PDB:3D8V,PDB:3D98,PDB:3DJ4,PDB:3FOQ,PDB:3SPT,PDB:3ST8,PDB:4G3Q,PDB:4G3S,PDB:4G87,PDB:4HCQ,NCBI_GP:CCP43768.1;Name=CCP43768.1;Note=Rv1018c%2C (MTCY10G2.31)%2C len: 495 aa. Probable glmU%2CUDP-n-acetylglucosamine pyrophosphorylase%2C similar to GCAD_BACSU|P14192 UDP-n-acetylglucosamine pyrophosphorylase (456 aa)%2C FASTA scores: opt: 1150%2C E(): 0%2C (40.0%25 identity in 453 aa overlap). Similar to various Mycobacterium tuberculosis sugar-phosphate transferases e.g. Rv0334%2CRv1213%2C Rv3264c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glmU;locus_tag=Rv1018c;product=Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU;protein_id=CCP43768.1;transl_table=11
AL123456.3	EMBL	gene	1138076	1138147	.	-	.	ID=gene-glnT;Name=glnT;gbkey=Gene;gene=glnT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1138076	1138147	.	-	.	ID=rna-glnT;Parent=gene-glnT;Note=codon recognized: CAA%3B glnT%2C tRNA-Gln%2C anticodon ttg%2C length %3D 72;anticodon=(pos:complement(1138112..1138114));gbkey=tRNA;gene=glnT;product=tRNA-Gln
AL123456.3	EMBL	exon	1138076	1138147	.	-	.	ID=exon-glnT-1;Parent=rna-glnT;Note=codon recognized: CAA%3B glnT%2C tRNA-Gln%2C anticodon ttg%2C length %3D 72;anticodon=(pos:complement(1138112..1138114));gbkey=tRNA;gene=glnT;product=tRNA-Gln
AL123456.3	EMBL	gene	1138315	1138908	.	+	.	ID=gene-Rv1019;Name=Rv1019;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1019
AL123456.3	EMBL	CDS	1138315	1138908	.	+	0	ID=cds-CCP43769.1;Parent=gene-Rv1019;Dbxref=EnsemblGenomes-Gn:Rv1019,EnsemblGenomes-Tr:CCP43769,GOA:P96381,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR023772,UniProtKB/TrEMBL:P96381,NCBI_GP:CCP43769.1;Name=CCP43769.1;Note=Rv1019%2C (MTCY10G2.30c)%2C len: 197 aa. Probable transcriptional regulator%2C similar to many memebers of the TetR family e.g. MTCY7D11.18c (34.4%25 identity in 189 aa overlap). Helix turn helix motif from aa 27-48 (+5.42 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1019;product=Probable transcriptional regulatory protein (probably TetR-family);protein_id=CCP43769.1;transl_table=11
AL123456.3	EMBL	gene	1138967	1142671	.	+	.	ID=gene-Rv1020;Name=mfd;gbkey=Gene;gene=mfd;gene_biotype=protein_coding;gene_synonym=trcF;locus_tag=Rv1020
AL123456.3	EMBL	CDS	1138967	1142671	.	+	0	ID=cds-CCP43770.1;Parent=gene-Rv1020;Dbxref=EnsemblGenomes-Gn:Rv1020,EnsemblGenomes-Tr:CCP43770,GOA:P9WMQ5,InterPro:IPR001650,InterPro:IPR003711,InterPro:IPR004576,InterPro:IPR005118,InterPro:IPR011545,InterPro:IPR014001,InterPro:IPR027417,NCBI_GP:CCP43770.1;Name=CCP43770.1;Note=Rv1020%2C (MTCY10G2.29c)%2C len: 1234 aa. Probable mfd (alternate gene name: trcF)%2C transcription-repair coupling factor (see citation below)%2C similar to many e.g. MFD_ECOLI|P30958 transcription-repair coupling factor from Escherichia coli (1148 aa)%2C FASTA scores: opt: 1900%2C E(): 0%2C (37.9%25 identity in 1107 aa overlap)%3B similar to M. tuberculosis Rv2973c and Rv1633. Contains PS00017 ATP/GTP-binding site motif A (P-loop). In the N-terminal section%3B belongs to the UVRB family. In the C-terminal section%3B belongs to the helicase family. RECG subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mfd;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1020;product=Probable transcription-repair coupling factor Mfd (TRCF);protein_id=CCP43770.1;transl_table=11
AL123456.3	EMBL	gene	1142671	1143648	.	+	.	ID=gene-Rv1021;Name=Rv1021;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1021
AL123456.3	EMBL	CDS	1142671	1143648	.	+	0	ID=cds-CCP43771.1;Parent=gene-Rv1021;Dbxref=EnsemblGenomes-Gn:Rv1021,EnsemblGenomes-Tr:CCP43771,GOA:P96379,InterPro:IPR004518,NCBI_GP:CCP43771.1;Name=CCP43771.1;Note=Rv1021%2C (MTCY10G2.28c)%2C len: 325 aa. Conserved protein%2C similar to YBL1_STRCI|P33653 hypothetical 26.1 kDa protein from Streptomyces cacaoi (242 aa)%2C FASTA scores: opt: 493%2C E(): 1.1e-23%2C (42.9%25 identity in 238 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1021;product=Conserved protein;protein_id=CCP43771.1;transl_table=11
AL123456.3	EMBL	gene	1143736	1144467	.	+	.	ID=gene-Rv1022;Name=lpqU;gbkey=Gene;gene=lpqU;gene_biotype=protein_coding;locus_tag=Rv1022
AL123456.3	EMBL	CDS	1143736	1144467	.	+	0	ID=cds-CCP43772.1;Parent=gene-Rv1022;Dbxref=EnsemblGenomes-Gn:Rv1022,EnsemblGenomes-Tr:CCP43772,GOA:P96378,InterPro:IPR023346,UniProtKB/TrEMBL:P96378,NCBI_GP:CCP43772.1;Name=CCP43772.1;Note=Rv1022%2C (MTCY10G2.27c)%2C len: 243 aa. Probable lpqU conserved lipoprotein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1230c|MTV006.02C%2C FASTA scores: E(): 2.8e-18%2C (37.9%25 identity in 240 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa)%2C FASTA scores: opt: 474%2CE(): 2.7e-21%2C (42.2%25 identity in 211 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqU;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1022;product=Probable conserved lipoprotein LpqU;protein_id=CCP43772.1;transl_table=11
AL123456.3	EMBL	gene	1144564	1145853	.	+	.	ID=gene-Rv1023;Name=eno;gbkey=Gene;gene=eno;gene_biotype=protein_coding;locus_tag=Rv1023
AL123456.3	EMBL	CDS	1144564	1145853	.	+	0	ID=cds-CCP43773.1;Parent=gene-Rv1023;Dbxref=EnsemblGenomes-Gn:Rv1023,EnsemblGenomes-Tr:CCP43773,GOA:P9WNL1,InterPro:IPR000941,InterPro:IPR020809,InterPro:IPR020810,InterPro:IPR020811,InterPro:IPR029017,InterPro:IPR029065,NCBI_GP:CCP43773.1;Name=CCP43773.1;Note=Rv1023%2C (MTCY10G2.26c)%2C len: 429 aa. Probable eno%2Cenolase%2C highly similar to others e.g. ENO_ECOLI|P08324 enolase from Escherichia coli (431 aa)%2C FASTA scores: opt: 1487%2C E(): 0%2C (55.5%25 identity in 422 aa overlap)%3B etc. Magnesium is required for catalysis and for stabilizing the dimer. Belongs to the enolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eno;locus_tag=Rv1023;product=Probable enolase Eno;protein_id=CCP43773.1;transl_table=11
AL123456.3	EMBL	gene	1145858	1146544	.	+	.	ID=gene-Rv1024;Name=Rv1024;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1024
AL123456.3	EMBL	CDS	1145858	1146544	.	+	0	ID=cds-CCP43774.1;Parent=gene-Rv1024;Dbxref=EnsemblGenomes-Gn:Rv1024,EnsemblGenomes-Tr:CCP43774,GOA:P96376,InterPro:IPR007060,UniProtKB/TrEMBL:P96376,NCBI_GP:CCP43774.1;Name=CCP43774.1;Note=Rv1024%2C (MTCY10G2.25c)%2C len: 228 aa. Possible conserved membrane protein%2C with a hydrophobic region from aa 83-101. Equivalent to ML0256|NP_301311.1|NC_002677 possible conserved membrane protein from Mycobacterium leprae (227 aa)%2C S%26W scores: 178%2C E()%3D 2e-72%2C Identities: 145/203 (71%25). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1024;product=Possible conserved membrane protein;protein_id=CCP43774.1;transl_table=11
AL123456.3	EMBL	gene	1146561	1147028	.	+	.	ID=gene-Rv1025;Name=Rv1025;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1025
AL123456.3	EMBL	CDS	1146561	1147028	.	+	0	ID=cds-CCP43775.1;Parent=gene-Rv1025;Dbxref=EnsemblGenomes-Gn:Rv1025,EnsemblGenomes-Tr:CCP43775,GOA:P96375,InterPro:IPR007511,UniProtKB/TrEMBL:P96375,NCBI_GP:CCP43775.1;Name=CCP43775.1;Note=Rv1025%2C (MTCY10G2.24c)%2C len: 155 aa. Conserved protein%2C similar to hypothetical protein AE001768|AE001768_4 Thermotoga maritima (170 aa) FASTA scores: opt: 254%2C E(): 9.5e-10%2C (35.7%25 identity in 143 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1025;product=Conserved protein;protein_id=CCP43775.1;transl_table=11
AL123456.3	EMBL	gene	1147019	1147978	.	+	.	ID=gene-Rv1026;Name=Rv1026;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1026
AL123456.3	EMBL	CDS	1147019	1147978	.	+	0	ID=cds-CCP43776.1;Parent=gene-Rv1026;Dbxref=EnsemblGenomes-Gn:Rv1026,EnsemblGenomes-Tr:CCP43776,GOA:P96374,InterPro:IPR003695,UniProtKB/TrEMBL:P96374,NCBI_GP:CCP43776.1;Name=CCP43776.1;Note=Rv1026%2C (MTCY10G2.23c)%2C len: 319 aa. Conserved protein. Similar to GPPA_ECOLI|P25552 guanosine-5'-triphosphate%2C3'-diphosphate pyrophoshatase from Escherichia coli (494 aa)%2C FASTA scores: opt: 281%2CE(): 3.2e-11%2C (30.6%25 identity in 291 aa overlap). Equivalent to AL023514|MLCB4.02 hypothetical protein from Mycobacterium leprae (317 aa) (77.9%25 identity in 321 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1026;product=Conserved protein;protein_id=CCP43776.1;transl_table=11
AL123456.3	EMBL	gene	1148427	1149107	.	-	.	ID=gene-Rv1027c;Name=kdpE;gbkey=Gene;gene=kdpE;gene_biotype=protein_coding;locus_tag=Rv1027c
AL123456.3	EMBL	CDS	1148427	1149107	.	-	0	ID=cds-CCP43777.1;Parent=gene-Rv1027c;Dbxref=EnsemblGenomes-Gn:Rv1027c,EnsemblGenomes-Tr:CCP43777,GOA:P9WGN1,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,NCBI_GP:CCP43777.1;Name=CCP43777.1;Note=Rv1027c%2C (MTCY10G2.22)%2C len: 226 aa. Probable KdpE%2Ctranscriptional regulatory protein%2C similar to others e.g. KDPE_ECOLI|P21866 kdp operon transcriptional regulatory protein from Escherichia coli strain K12 (225 aa)%2C FASTA scores: opt: 691%2C E(): 0%2C (47.8%25 identity in 224 aa overlap)%3B AL021530|SC2E9.13 from Streptomyces coelicolor (227 aa)%2C FASTA scores: opt: 981%2C E(): 0%2C (66.4%25 identity in 226 aa overlap)%3B etc.;gbkey=CDS;gene=kdpE;locus_tag=Rv1027c;product=Probable transcriptional regulatory protein KdpE;protein_id=CCP43777.1;transl_table=11
AL123456.3	EMBL	gene	1149104	1151686	.	-	.	ID=gene-Rv1028c;Name=kdpD;gbkey=Gene;gene=kdpD;gene_biotype=protein_coding;locus_tag=Rv1028c
AL123456.3	EMBL	CDS	1149104	1151686	.	-	0	ID=cds-CCP43778.1;Parent=gene-Rv1028c;Dbxref=EnsemblGenomes-Gn:Rv1028c,EnsemblGenomes-Tr:CCP43778,GOA:P9WGL3,InterPro:IPR003594,InterPro:IPR003661,InterPro:IPR003852,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR006016,InterPro:IPR009082,InterPro:IPR014729,InterPro:IPR027417,NCBI_GP:CCP43778.1;Name=CCP43778.1;Note=Rv1028c%2C (MTCY10G2.21)%2C len: 860 aa. Probable kdpD%2Csensor protein%2C similar to others e.g. KDPD_ECOLI|P21865 sensor protein from Escherichia coli strain K12 (894 aa)%2CFASTA scores: opt: 1041%2C E(): 0%2C (32.3%25 identity in 888 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to universal stress protein family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kdpD;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1028c;product=Probable sensor protein KdpD;protein_id=CCP43778.1;transl_table=11
AL123456.3	EMBL	gene	1151920	1152012	.	+	.	ID=gene-Rv1028A;Name=kdpF;gbkey=Gene;gene=kdpF;gene_biotype=protein_coding;locus_tag=Rv1028A
AL123456.3	EMBL	CDS	1151920	1152012	.	+	0	ID=cds-CCP43779.1;Parent=gene-Rv1028A;Dbxref=EnsemblGenomes-Gn:Rv1028A,EnsemblGenomes-Tr:CCP43779,GOA:Q79FT7,InterPro:IPR011726,UniProtKB/TrEMBL:Q79FT7,NCBI_GP:CCP43779.1;Name=CCP43779.1;Note=Rv1028A%2C len: 30 aa. Probable kdpF%2C membrane protein%2C showing similarity with P36937|KDPF_ECOLI|B0698.1 protein KDPF from Escherichia coli strain K12 (see citation below) (27%25 identity)%3B and KdpF protein from Streptomyces coelicolor (51%25 identity).;gbkey=CDS;gene=kdpF;locus_tag=Rv1028A;product=Probable membrane protein KdpF;protein_id=CCP43779.1;transl_table=11
AL123456.3	EMBL	gene	1152012	1153727	.	+	.	ID=gene-Rv1029;Name=kdpA;gbkey=Gene;gene=kdpA;gene_biotype=protein_coding;locus_tag=Rv1029
AL123456.3	EMBL	CDS	1152012	1153727	.	+	0	ID=cds-CCP43780.1;Parent=gene-Rv1029;Dbxref=EnsemblGenomes-Gn:Rv1029,EnsemblGenomes-Tr:CCP43780,GOA:P9WKF3,InterPro:IPR004623,NCBI_GP:CCP43780.1;Name=CCP43780.1;Note=Rv1029%2C (MTCY10G2.20c)%2C len: 571 aa. Probable kdpA%2Cpotassium-transporting ATPase a chain (transmembrane protein)%2C similar to others e.g. ATKA_ECOLI|P03959|KDPA|B0698 potassium-transporting ATPase A chain from Escherichia coli strain K12 (557 aa)%2C FASTA scores: opt: 1763%2C E(): 0%2C (50.4%25 identity in 569 aa overlap)%3B etc. Belongs to the KdpA family.;gbkey=CDS;gene=kdpA;locus_tag=Rv1029;product=Probable potassium-transporting ATPase a chain KdpA (potassium-translocating ATPase a chain) (ATP phosphohydrolase [potassium-transporting] a chain) (potassium binding and translocating subunit A);protein_id=CCP43780.1;transl_table=11
AL123456.3	EMBL	gene	1153724	1155853	.	+	.	ID=gene-Rv1030;Name=kdpB;gbkey=Gene;gene=kdpB;gene_biotype=protein_coding;locus_tag=Rv1030
AL123456.3	EMBL	CDS	1153724	1155853	.	+	0	ID=cds-CCP43781.1;Parent=gene-Rv1030;Dbxref=EnsemblGenomes-Gn:Rv1030,EnsemblGenomes-Tr:CCP43781,GOA:P9WPU3,InterPro:IPR001757,InterPro:IPR006391,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,NCBI_GP:CCP43781.1;Name=CCP43781.1;Note=Rv1030%2C (MTCY10G2.19c)%2C len: 709 aa. Probable kdpB%2Cpotassium-transporting P-type ATPase B chain (transmembrane protein)%2C similar to others e.g. ATKB_ECOLI|P03960 potassium-transporting ATPase B chain from Escherichia coli strain K12 (682 aa)%2C FASTA scores: opt: 1481%2C E(): 0%2C(63.4%25 identity in 686 aa overlap)%3B etc. Very similar to AL078610|SCH35.47 H+/K+-exchanging ATPase chain B from Streptomyces coelicolor (707 aa)%2C FASTA scores: opt: 2731%2CE(): 0%2C (71.6%25 identity in 676 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kdpB;inference=protein motif:PROSITE:PS00154;locus_tag=Rv1030;product=Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B);protein_id=CCP43781.1;transl_table=11
AL123456.3	EMBL	gene	1155853	1156422	.	+	.	ID=gene-Rv1031;Name=kdpC;gbkey=Gene;gene=kdpC;gene_biotype=protein_coding;locus_tag=Rv1031
AL123456.3	EMBL	CDS	1155853	1156422	.	+	0	ID=cds-CCP43782.1;Parent=gene-Rv1031;Dbxref=EnsemblGenomes-Gn:Rv1031,EnsemblGenomes-Tr:CCP43782,GOA:P9WKF1,InterPro:IPR003820,NCBI_GP:CCP43782.1;Name=CCP43782.1;Note=Rv1031%2C (MTCY10G2.18c)%2C len: 189 aa. Probable kdpC%2Cpotassium-transporting ATPase C chain (membrane protein) %2Csimilar to others e.g. ATKC_ECOLI|P03961 potassium-transporting ATPase C chain from Escherichia coli strain K12 (190 aa)%2C FASTA scores: opt: 475%2C E(): 3.1e-24%2C(45.7%25 identity in 186 aa overlap)%3B etc. Belongs to the KdpC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kdpC;locus_tag=Rv1031;product=Probable potassium-transporting ATPase C chain KdpC (potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C);protein_id=CCP43782.1;transl_table=11
AL123456.3	EMBL	gene	1156426	1157955	.	-	.	ID=gene-Rv1032c;Name=trcS;gbkey=Gene;gene=trcS;gene_biotype=protein_coding;locus_tag=Rv1032c
AL123456.3	EMBL	CDS	1156426	1157955	.	-	0	ID=cds-CCP43783.1;Parent=gene-Rv1032c;Dbxref=EnsemblGenomes-Gn:Rv1032c,EnsemblGenomes-Tr:CCP43783,GOA:P96368,InterPro:IPR003594,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR009082,UniProtKB/TrEMBL:P96368,NCBI_GP:CCP43783.1;Name=CCP43783.1;Note=Rv1032c%2C (MTCY10G2.17)%2C len: 509 aa. TrcS%2C two component sensor histidine kinase protein (see citations below)%2C similar to YV16_MYCLE|P54883 probable sensor-like histidine kinase from Mycobacterium leprae (443 aa)%2C FASTA scores: opt: 392%2C E(): 3.8e-18%2C (31.7%25 identity in 334 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+ or Ca2+ as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.;gbkey=CDS;gene=trcS;locus_tag=Rv1032c;product=Two component sensor histidine kinase TrcS;protein_id=CCP43783.1;transl_table=11
AL123456.3	EMBL	gene	1157963	1158736	.	-	.	ID=gene-Rv1033c;Name=trcR;gbkey=Gene;gene=trcR;gene_biotype=protein_coding;locus_tag=Rv1033c
AL123456.3	EMBL	CDS	1157963	1158736	.	-	0	ID=cds-CCP43784.1;Parent=gene-Rv1033c;Dbxref=EnsemblGenomes-Gn:Rv1033c,EnsemblGenomes-Tr:CCP43784,GOA:L7N689,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,InterPro:IPR016032,UniProtKB/TrEMBL:L7N689,NCBI_GP:CCP43784.1;Name=CCP43784.1;Note=Rv1033c%2C (MTCY10G2.16)%2C len: 257 aa. TrcR%2Ctwo-component regulatory protein (see citations below)%2Csimilar to Q50825 two component response regulator from Mycobacterium tuberculosis (234 aa)%2C FASTA scores: opt: 628%2C E(): 0%2C (46.0%25 identity in 226 aa overlap). Note that in vitro autophosphorylation of TrcS requires the presence of Mn2+or Ca2+as a divalent cation cofactor and subsequent transphosphorylation of TrcR is evident in the presence of TrcS-phosphate and Ca2+.;gbkey=CDS;gene=trcR;locus_tag=Rv1033c;product=Two component transcriptional regulator TrcR;protein_id=CCP43784.1;transl_table=11
AL123456.3	EMBL	gene	1158918	1159307	.	-	.	ID=gene-Rv1034c;Name=Rv1034c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1034c
AL123456.3	EMBL	CDS	1158918	1159307	.	-	0	ID=cds-CCP43785.1;Parent=gene-Rv1034c;Dbxref=EnsemblGenomes-Gn:Rv1034c,EnsemblGenomes-Tr:CCP43785,UniProtKB/TrEMBL:I6X043,NCBI_GP:CCP43785.1;Name=CCP43785.1;Note=Rv1034c%2C (MTCY10G2.15)%2C len: 129 aa. Probable IS1560 transposase fragment%2C similar to part of Rv3387|E1202305|MTV004.45 (225 aa) (65.1%25 identity in 129 aa overlap).;gbkey=CDS;locus_tag=Rv1034c;product=Probable transposase (fragment);protein_id=CCP43785.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1158921	1160433	.	-	.	ID=id-AL123456.3:1158921..1160433;Note=IS1560-1%2C len: 1513 nt. Insertion sequence IS1560.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1560-1
AL123456.3	EMBL	gene	1159375	1160061	.	-	.	ID=gene-Rv1035c;Name=Rv1035c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1035c
AL123456.3	EMBL	CDS	1159375	1160061	.	-	0	ID=cds-CCP43786.1;Parent=gene-Rv1035c;Dbxref=EnsemblGenomes-Gn:Rv1035c,EnsemblGenomes-Tr:CCP43786,GOA:P96366,UniProtKB/TrEMBL:P96366,NCBI_GP:CCP43786.1;Name=CCP43786.1;Note=Rv1035c%2C (MTCY10G2.14)%2C len: 228 aa. Probable IS1560 transposase fragment%2C similar to parts of Rv3387|E1202305|MTV004.45 (225 aa) (47.8%25 identity in 67 aa overlap) and Rv3386|E1202304|MTV004.44 (234 aa) (55.1%25 identity in 127 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1035c;product=Probable transposase (fragment);protein_id=CCP43786.1;transl_table=11
AL123456.3	EMBL	gene	1160095	1160433	.	-	.	ID=gene-Rv1036c;Name=Rv1036c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1036c
AL123456.3	EMBL	CDS	1160095	1160433	.	-	0	ID=cds-CCP43787.1;Parent=gene-Rv1036c;Dbxref=EnsemblGenomes-Gn:Rv1036c,EnsemblGenomes-Tr:CCP43787,UniProtKB/TrEMBL:P96365,NCBI_GP:CCP43787.1;Name=CCP43787.1;Note=Rv1036c%2C (MTCY10G2.13)%2C len: 112 aa. Probable IS1560 transposase fragment%2C similar to part of Rv3386|E1202304|MTV004.44 (234 aa) (82.8%25 identity in 87 aa overlap).;gbkey=CDS;locus_tag=Rv1036c;product=Probable IS1560 transposase (fragment);protein_id=CCP43787.1;transl_table=11
AL123456.3	EMBL	gene	1160544	1160828	.	-	.	ID=gene-Rv1037c;Name=esxI;gbkey=Gene;gene=esxI;gene_biotype=protein_coding;gene_synonym=ES6_1,Mtb9.9D;locus_tag=Rv1037c
AL123456.3	EMBL	CDS	1160544	1160828	.	-	0	ID=cds-CCP43788.1;Parent=gene-Rv1037c;Dbxref=EnsemblGenomes-Gn:Rv1037c,EnsemblGenomes-Tr:CCP43788,GOA:P9WNK1,InterPro:IPR009416,InterPro:IPR010310,NCBI_GP:CCP43788.1;Name=CCP43788.1;Note=Rv1037c%2C (MTCY10G2.12)%2C len: 94 aa. EsxI%2C ESAT-6 like protein (see citations below)%2C highly similar to Q49946|ES6X_MYCLE|U1756D putative ESAT-6 like protein X from Mycobacterium leprae (95 aa)%2C FASTA scores: opt: 409%2CE(): 6.3e-23%2C (64.15%25 identity in 92 aa overlap)%3B Rv3619c%2CRv1198%2C Rv2346c%2C etc from Mycobacterium tuberculosis. Strictly identical to P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT3721 putative ESAT-6 like protein 1 (94 aa). Belongs to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxI;locus_tag=Rv1037c;product=Putative ESAT-6 like protein EsxI (ESAT-6 like protein 1);protein_id=CCP43788.1;transl_table=11
AL123456.3	EMBL	gene	1160855	1161151	.	-	.	ID=gene-Rv1038c;Name=esxJ;gbkey=Gene;gene=esxJ;gene_biotype=protein_coding;gene_synonym=ES6_2,QILSS,TB11.0;locus_tag=Rv1038c
AL123456.3	EMBL	CDS	1160855	1161151	.	-	0	ID=cds-CCP43789.1;Parent=gene-Rv1038c;Dbxref=EnsemblGenomes-Gn:Rv1038c,EnsemblGenomes-Tr:CCP43789,GOA:P9WNJ9,InterPro:IPR010310,NCBI_GP:CCP43789.1;Name=CCP43789.1;Note=Rv1038c%2C (MT1067%2C MTCY10G2.11)%2C len: 98 aa. EsxJ%2CESAT-6 like protein (see Gey Van Pittius et al.%2C 2001)%2Csimilar to Q49945|U1756C%2C Mycobacterium leprae (100 aa)%2CFASTA scores: opt: 375%2C E(): 7.7e-21%2C (58.3%25 identity in 96 aa overlap). Member of M. tuberculosis hypothetical QILSS protein family with Rv1197%2C Rv1792%2C Rv2347c and Rv3620c. Belongs to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxJ;locus_tag=Rv1038c;product=ESAT-6 like protein EsxJ (ESAT-6 like protein 2);protein_id=CCP43789.1;transl_table=11
AL123456.3	EMBL	gene	1161297	1162472	.	-	.	ID=gene-Rv1039c;Name=PPE15;gbkey=Gene;gene=PPE15;gene_biotype=protein_coding;locus_tag=Rv1039c
AL123456.3	EMBL	CDS	1161297	1162472	.	-	0	ID=cds-CCP43790.1;Parent=gene-Rv1039c;Dbxref=EnsemblGenomes-Gn:Rv1039c,EnsemblGenomes-Tr:CCP43790,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP43790.1;Name=CCP43790.1;Note=Rv1039c%2C (MTCY10G2.10)%2C len: 391 aa. PPE15%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C most similar to Rv2768c|AL008967|MTV002_33 Mycobacterium tuberculosis H37Rv (394 aa)%2C FASTA scores: opt: 1721%2C E(): 0%2C (70.4%25 identity in 398 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE15;locus_tag=Rv1039c;product=PPE family protein PPE15;protein_id=CCP43790.1;transl_table=11
AL123456.3	EMBL	gene	1162549	1163376	.	-	.	ID=gene-Rv1040c;Name=PE8;gbkey=Gene;gene=PE8;gene_biotype=protein_coding;locus_tag=Rv1040c
AL123456.3	EMBL	CDS	1162549	1163376	.	-	0	ID=cds-CCP43791.1;Parent=gene-Rv1040c;Dbxref=EnsemblGenomes-Gn:Rv1040c,EnsemblGenomes-Tr:CCP43791,InterPro:IPR000084,InterPro:IPR022171,UniProtKB/TrEMBL:L7N667,NCBI_GP:CCP43791.1;Name=CCP43791.1;Note=Rv1040c%2C (MTCY10G2.09)%2C len: 275 aa. PE8%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C most similar to AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 aa)%2C FASTA scores: opt: 1111%2C E(): 0%2C (68.6%25 identity in 283 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=PE8;locus_tag=Rv1040c;product=PE family protein PE8;protein_id=CCP43791.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1164572	1165549	.	-	.	ID=id-AL123456.3:1164572..1165549;Note=IS-LIKE-1%2C len: 978 nt. Insertion sequence%2C ISLIKE%2Cregion identical to cosmid y348%2C blast score%3D 4902 (+1) 9377 10354 EM_NEW:MTAD20 Ad000020 Mycobacterium tuberculosis sequence from clone y348. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS-LIKE-1
AL123456.3	EMBL	gene	1164572	1165435	.	-	.	ID=gene-Rv1041c;Name=Rv1041c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1041c
AL123456.3	EMBL	CDS	1164572	1165435	.	-	0	ID=cds-CCP43792.1;Parent=gene-Rv1041c;Dbxref=EnsemblGenomes-Gn:Rv1041c,EnsemblGenomes-Tr:CCP43792,GOA:P96360,InterPro:IPR002559,UniProtKB/TrEMBL:P96360,NCBI_GP:CCP43792.1;Name=CCP43792.1;Note=Rv1041c%2C (MTCY10G2.08)%2C len: 287 aa. Probable is like-2 transposase%2C overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (186 aa)%2C FASTA scores: opt: 173%2C E(): 0.00016%2C (40.9%25 identity in 176 aa overlap). Similar to Rv1150%2C C-terminal part of transposase of putative Mycobacterium tuberculosis is like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with respect to Mycobacterium tuberculosis Q50761 transposase%2C the 10G2 cosmid sequence appears to be correct. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1041c;product=Probable is like-2 transposase;protein_id=CCP43792.1;transl_table=11
AL123456.3	EMBL	repeat_region	1164572	1164589	.	+	.	ID=id-AL123456.3:1164572..1164589;Note=18 bp inverted repeat at the left end of IS-LIKE element%2C CTAGGGCGTGTCTCCCAA. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	1165092	1165499	.	-	.	ID=gene-Rv1042c;Name=Rv1042c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1042c
AL123456.3	EMBL	CDS	1165092	1165499	.	-	0	ID=cds-CCP43793.1;Parent=gene-Rv1042c;Dbxref=EnsemblGenomes-Gn:Rv1042c,EnsemblGenomes-Tr:CCP43793,InterPro:IPR025161,UniProtKB/TrEMBL:L0T897,NCBI_GP:CCP43793.1;Name=CCP43793.1;Note=Rv1042c%2C (MTCY10G2.07)%2C len: 135 aa. Probable is like-2 transposase%2C similar to Q50761 transposase from Mycobacterium tuberculosis (308 aa)%2C FASTA scores: opt: 823%2C E(): 0%2C (99.1%25 identity in 117 aa overlap). Second copy is Rv1149. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1042c;product=Probable is like-2 transposase;protein_id=CCP43793.1;transl_table=11
AL123456.3	EMBL	repeat_region	1165532	1165549	.	-	.	ID=id-AL123456.3:1165532..1165549;Note=18 bp inverted repeat at the right end of a IS-LIKE element%2C CTAGGGCGTGTCTCCCAA. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	1165781	1166806	.	-	.	ID=gene-Rv1043c;Name=Rv1043c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1043c
AL123456.3	EMBL	CDS	1165781	1166806	.	-	0	ID=cds-CCP43794.1;Parent=gene-Rv1043c;Dbxref=EnsemblGenomes-Gn:Rv1043c,EnsemblGenomes-Tr:CCP43794,GOA:P96358,InterPro:IPR009003,UniProtKB/TrEMBL:P96358,NCBI_GP:CCP43794.1;Name=CCP43794.1;Note=Rv1043c%2C (MTCY10G2.06)%2C len: 341 aa. Conserved hypothetical protein similar to AL096872|SC5F7.08 putative lipoate-protein ligase from Streptomyces coelicolor (362 aa)%2C FASTA scores: opt: 206%2C E(): 1.4e-05%2C (30.3%25 identity in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU hypothetical protease from Bacillus subtitis (400 aa)%2CFASTA scores: opt: 159%2C E(): 0.013%2C (27.1%25 identity in 210 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1043c;product=Conserved hypothetical protein;protein_id=CCP43794.1;transl_table=11
AL123456.3	EMBL	gene	1167053	1167676	.	+	.	ID=gene-Rv1044;Name=Rv1044;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1044
AL123456.3	EMBL	CDS	1167053	1167676	.	+	0	ID=cds-CCP43795.1;Parent=gene-Rv1044;Dbxref=EnsemblGenomes-Gn:Rv1044,EnsemblGenomes-Tr:CCP43795,InterPro:IPR025159,UniProtKB/TrEMBL:P96357,NCBI_GP:CCP43795.1;Name=CCP43795.1;Note=Rv1044%2C (MTCY10G2.05c)%2C len: 207 aa. Conserved hypothetical protein%2C similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa)%2C fasta scores: E(): 8.9e-06%2C (30.7%25 identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa)%2C FASTA scores: opt: 147%2C E (): 0.0087%2C (29.7%25 identity in 91 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1044;product=Conserved hypothetical protein;protein_id=CCP43795.1;transl_table=11
AL123456.3	EMBL	gene	1167673	1168554	.	+	.	ID=gene-Rv1045;Name=Rv1045;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1045
AL123456.3	EMBL	CDS	1167673	1168554	.	+	0	ID=cds-CCP43796.1;Parent=gene-Rv1045;Dbxref=EnsemblGenomes-Gn:Rv1045,EnsemblGenomes-Tr:CCP43796,InterPro:IPR014942,UniProtKB/TrEMBL:P96356,NCBI_GP:CCP43796.1;Name=CCP43796.1;Note=Rv1045%2C (MTCY10G2.04c)%2C len: 293 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1045;product=Hypothetical protein;protein_id=CCP43796.1;transl_table=11
AL123456.3	EMBL	gene	1168704	1169228	.	-	.	ID=gene-Rv1046c;Name=Rv1046c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1046c
AL123456.3	EMBL	CDS	1168704	1169228	.	-	0	ID=cds-CCP43797.1;Parent=gene-Rv1046c;Dbxref=EnsemblGenomes-Gn:Rv1046c,EnsemblGenomes-Tr:CCP43797,UniProtKB/TrEMBL:L0T8G6,NCBI_GP:CCP43797.1;Name=CCP43797.1;Note=Rv1046c%2C (MTCY10G2.03)%2C len: 174 aa. Hypothetical unknown protein. Start changed since first submission (-65 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1046c;product=Hypothetical protein;protein_id=CCP43797.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1169298	1170732	.	+	.	ID=id-AL123456.3:1169298..1170732;Note=IS1081-1%2C len: 1435 nt. Insertion sequence IS1081%2Calmost identical to Mycobacterium bovis IS1081 (7157 (-1) 60 14 94 EM_BA:MBBIS1081 X84741 Mycobacterium bovis BCG IS1081 DNA. 4/96. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1081-1
AL123456.3	EMBL	gene	1169423	1170670	.	+	.	ID=gene-Rv1047;Name=Rv1047;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1047
AL123456.3	EMBL	CDS	1169423	1170670	.	+	0	ID=cds-CCP43798.1;Parent=gene-Rv1047;Dbxref=EnsemblGenomes-Gn:Rv1047,EnsemblGenomes-Tr:CCP43798,GOA:P96354,InterPro:IPR001207,UniProtKB/TrEMBL:P96354,NCBI_GP:CCP43798.1;Name=CCP43798.1;Note=Rv1047%2C (MTCY10G2.02c)%2C len: 415 aa. IS1081 transposase%2C most similar to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa)%2C FASTA scores: opt: 2675%2C E(): 0%2C (99.8%25 identity in 415 aa overlap). Contains PS01007 Transposases%2C Mutator family%2C signature. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;inference=protein motif:PROSITE:PS01007;locus_tag=Rv1047;product=Probable transposase;protein_id=CCP43798.1;transl_table=11
AL123456.3	EMBL	gene	1171038	1172153	.	-	.	ID=gene-Rv1048c;Name=Rv1048c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1048c
AL123456.3	EMBL	CDS	1171038	1172153	.	-	0	ID=cds-CCP43799.1;Parent=gene-Rv1048c;Dbxref=EnsemblGenomes-Gn:Rv1048c,EnsemblGenomes-Tr:CCP43799,UniProtKB/TrEMBL:P96353,NCBI_GP:CCP43799.1;Name=CCP43799.1;Note=Rv1048c%2C (MTV017.01c-MTCY10G2.01)%2C len: 371 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1048c;product=Hypothetical protein;protein_id=CCP43799.1;transl_table=11
AL123456.3	EMBL	gene	1172386	1172832	.	+	.	ID=gene-Rv1049;Name=Rv1049;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1049
AL123456.3	EMBL	CDS	1172386	1172832	.	+	0	ID=cds-CCP43800.1;Parent=gene-Rv1049;Dbxref=EnsemblGenomes-Gn:Rv1049,EnsemblGenomes-Tr:CCP43800,GOA:I6Y5H3,InterPro:IPR000835,InterPro:IPR011991,UniProtKB/TrEMBL:I6Y5H3,NCBI_GP:CCP43800.1;Name=CCP43800.1;Note=Rv1049%2C (MTV017.02)%2C len: 148 aa. Probable transcriptional repressor protein%2C similar to many e.g. P74870 negative regulator of EMR locus EMR from Salmonella typhimurium (149 aa)%2C FASTA scores: opt: 146%2C E(): 0.0011%2C(31.6%25 identity in 95 aa overlap). Contains probable helix-turn-helix motif at aa 58-79 (Score 1495%2C +4.28 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1049;product=Probable transcriptional repressor protein;protein_id=CCP43800.1;transl_table=11
AL123456.3	EMBL	gene	1172881	1173786	.	+	.	ID=gene-Rv1050;Name=Rv1050;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1050
AL123456.3	EMBL	CDS	1172881	1173786	.	+	0	ID=cds-CCP43801.1;Parent=gene-Rv1050;Dbxref=EnsemblGenomes-Gn:Rv1050,EnsemblGenomes-Tr:CCP43801,GOA:O53398,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O53398,NCBI_GP:CCP43801.1;Name=CCP43801.1;Note=Rv1050%2C (MTV017.03)%2C len: 301 aa. Probable oxidoreductase similar to many e.g. Rv1543|MTCY48.22C|Q10783 putative oxidoreductase CY48.22C (341 aa)%2C FASTA scores: opt: 462%2C E(): 3e-22%2C (33.6%25 identity in 265 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1050;product=Probable oxidoreductase;protein_id=CCP43801.1;transl_table=11
AL123456.3	EMBL	gene	1173945	1174700	.	-	.	ID=gene-Rv1051c;Name=Rv1051c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1051c
AL123456.3	EMBL	CDS	1173945	1174700	.	-	0	ID=cds-CCP43802.1;Parent=gene-Rv1051c;Dbxref=EnsemblGenomes-Gn:Rv1051c,EnsemblGenomes-Tr:CCP43802,GOA:O53399,InterPro:IPR009061,InterPro:IPR011991,InterPro:IPR014942,UniProtKB/TrEMBL:O53399,NCBI_GP:CCP43802.1;Name=CCP43802.1;Note=Rv1051c%2C (MTV017.04c)%2C len: 251 aa. Conserved hypothetical protein%2C similar to LLU36837|U36837.1 protein encoded by Lactococcus lactis plasmid pNP40 (298 aa)%2C FASTA scores: opt: 194%2C E(): 3.5e-06%2C (30.3%25 identity in 155 aa overlap). Contains possible helix-turn-helix motif at aa 197-218 (Score 1097%2C +2.92 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1051c;product=Conserved hypothetical protein;protein_id=CCP43802.1;transl_table=11
AL123456.3	EMBL	gene	1175225	1175315	.	+	.	ID=gene-mpr5;Name=mpr5;gbkey=Gene;gene=mpr5;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1175225	1175315	.	+	.	ID=rna-mpr5;Parent=gene-mpr5;Note=mpr5%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~100 nt band detected by Northern blot.;gbkey=ncRNA;gene=mpr5;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	1175225	1175315	.	+	.	ID=exon-mpr5-1;Parent=rna-mpr5;Note=mpr5%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~100 nt band detected by Northern blot.;gbkey=ncRNA;gene=mpr5;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	1175723	1176112	.	+	.	ID=gene-Rv1052;Name=Rv1052;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1052
AL123456.3	EMBL	CDS	1175723	1176112	.	+	0	ID=cds-CCP43803.1;Parent=gene-Rv1052;Dbxref=EnsemblGenomes-Gn:Rv1052,EnsemblGenomes-Tr:CCP43803,UniProtKB/TrEMBL:O53400,NCBI_GP:CCP43803.1;Name=CCP43803.1;Note=Rv1052%2C (MTV017.05)%2C len: 129 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1052;product=Hypothetical protein;protein_id=CCP43803.1;transl_table=11
AL123456.3	EMBL	gene	1176011	1176286	.	-	.	ID=gene-Rv1053c;Name=Rv1053c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1053c
AL123456.3	EMBL	CDS	1176011	1176286	.	-	0	ID=cds-CCP43804.1;Parent=gene-Rv1053c;Dbxref=EnsemblGenomes-Gn:Rv1053c,EnsemblGenomes-Tr:CCP43804,UniProtKB/TrEMBL:O53401,NCBI_GP:CCP43804.1;Name=CCP43804.1;Note=Rv1053c%2C (MTV017.06c)%2C len: 91 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1053c;product=Hypothetical protein;protein_id=CCP43804.1;transl_table=11
AL123456.3	EMBL	gene	1176928	1177242	.	+	.	ID=gene-Rv1054;Name=Rv1054;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1054
AL123456.3	EMBL	CDS	1176928	1177242	.	+	0	ID=cds-CCP43805.1;Parent=gene-Rv1054;Dbxref=EnsemblGenomes-Gn:Rv1054,EnsemblGenomes-Tr:CCP43805,GOA:O53402,InterPro:IPR011010,InterPro:IPR013762,InterPro:IPR014417,UniProtKB/TrEMBL:O53402,NCBI_GP:CCP43805.1;Name=CCP43805.1;Note=Rv1054%2C (MTV017.07)%2C len: 104 aa. Probable integrase (fragment)%2C similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa)%2C FASTA scores: opt: 273%2C E(): 8.8e-13%2C (64.7%25 identity in 68 aa overlap)%3B and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa)%2C FASTA scores: opt: 105%2C E(): 0.9%2C (31.8%25 identity in 85 aaoverlap). This ORF continues in another frame as Rv1055|MTV017.08 but no error can be found to account for frameshift. Length extended since first submission (+36 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1054;product=Probable integrase (fragment);protein_id=CCP43805.1;transl_table=11
AL123456.3	EMBL	gene	1177239	1177373	.	+	.	ID=gene-Rv1055;Name=Rv1055;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1055
AL123456.3	EMBL	CDS	1177239	1177373	.	+	0	ID=cds-CCP43806.1;Parent=gene-Rv1055;Dbxref=EnsemblGenomes-Gn:Rv1055,EnsemblGenomes-Tr:CCP43806,UniProtKB/TrEMBL:O53403,NCBI_GP:CCP43806.1;Name=CCP43806.1;Note=Rv1055%2C (MTV017.08)%2C len: 44 aa. Possible integrase (fragment)%3B first 49 aa similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 aa)%2C FASTA scores: opt: 291%2C E(): 2.2e-16%2C (74.3%25 identity in 70 aa overlap)%3B and to L39071|MSGINT_1 integrase from Mycobacterium paratuberculosis (191 aa)%2CFASTA scores: opt: 146%2C E(): 8.3e-05%2C (52.1%25 identity in 48 aa overlap)%3B and to many other integrases or transposases. Shortened since first submission (-34 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1055;product=Possible integrase (fragment);protein_id=CCP43806.1;transl_table=11
AL123456.3	EMBL	gene	1177396	1177469	.	+	.	ID=gene-leuX;Name=leuX;gbkey=Gene;gene=leuX;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1177396	1177469	.	+	.	ID=rna-leuX;Parent=gene-leuX;Note=codon recognized: UUA%3B leuX%2C tRNA-Leu%2C anticodon taa%2C length %3D 74. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;anticodon=(pos:1177430..1177432);gbkey=tRNA;gene=leuX;product=tRNA-Leu
AL123456.3	EMBL	exon	1177396	1177469	.	+	.	ID=exon-leuX-1;Parent=rna-leuX;Note=codon recognized: UUA%3B leuX%2C tRNA-Leu%2C anticodon taa%2C length %3D 74. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;anticodon=(pos:1177430..1177432);gbkey=tRNA;gene=leuX;product=tRNA-Leu
AL123456.3	EMBL	gene	1177628	1178392	.	+	.	ID=gene-Rv1056;Name=Rv1056;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1056
AL123456.3	EMBL	CDS	1177628	1178392	.	+	0	ID=cds-CCP43807.1;Parent=gene-Rv1056;Dbxref=EnsemblGenomes-Gn:Rv1056,EnsemblGenomes-Tr:CCP43807,GOA:O53404,InterPro:IPR007361,UniProtKB/TrEMBL:O53404,NCBI_GP:CCP43807.1;Name=CCP43807.1;Note=Rv1056%2C (MTV017.09)%2C len: 254 aa. Conserved protein%2Csome similarity in C-terminal region of Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126 aa)%2CFASTA scores: opt: 254%2C E(): 1.2e-10%2C (43.4%25 identity in 106 aa overlap)%3B and to Rv1670. C-terminal region is similar to AL035569|SC8D9.02 hypothetical protein from Streptomyces coelicolor (113 aa)%2C FASTA scores: opt: 282%2CE(): 4.5e-12%2C (48.0%25 identity in 100 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1056;product=Conserved protein;protein_id=CCP43807.1;transl_table=11
AL123456.3	EMBL	repeat_region	1179345	1179395	.	+	.	ID=id-AL123456.3:1179345..1179395;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	1179396	1180577	.	+	.	ID=gene-Rv1057;Name=Rv1057;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1057
AL123456.3	EMBL	CDS	1179396	1180577	.	+	0	ID=cds-CCP43808.1;Parent=gene-Rv1057;Dbxref=EnsemblGenomes-Gn:Rv1057,EnsemblGenomes-Tr:CCP43808,InterPro:IPR011048,InterPro:IPR015943,UniProtKB/TrEMBL:O53405,NCBI_GP:CCP43808.1;Name=CCP43808.1;Note=Rv1057%2C (MTV017.10)%2C len: 393 aa. Conserved hypothetical protein%2C some similarity to X84710|MMSAG_1 surface antigen of Methanosarcina mazeii (491 aa)%2C FASTA scores: opt: 363%2C E():6.2e-15%2C (31.3%25 identity in 294 aa overlap). Regulated by MprA (Rv0981) under physiological conditions and environmental stress (SDS and Triton X-100) (See He et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1057;product=Conserved hypothetical protein;protein_id=CCP43808.1;transl_table=11
AL123456.3	EMBL	gene	1180684	1182315	.	+	.	ID=gene-Rv1058;Name=fadD14;gbkey=Gene;gene=fadD14;gene_biotype=protein_coding;locus_tag=Rv1058
AL123456.3	EMBL	CDS	1180684	1182315	.	+	0	ID=cds-CCP43809.1;Parent=gene-Rv1058;Dbxref=EnsemblGenomes-Gn:Rv1058,EnsemblGenomes-Tr:CCP43809,GOA:O53406,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O53406,NCBI_GP:CCP43809.1;Name=CCP43809.1;Note=Rv1058%2C (MTV017.11)%2C len: 543 aa. Probable fadD14%2Cmedium-chain fatty-acid-CoA synthetase%2C highly similar to many e.g. CAC32346.1|AL583945 putative fatty acid CoA ligase from Streptomyces coelicolor (558 aa)%3B N-terminus of NP_419738.1|NC_002696 medium-chain-fatty-acid--CoA ligase from Caulobacter crescentus (1006 aa)%3B Q00594|ALKK_PSEOL medium-chain-fatty-acid--CoA ligase from Pseudomonas oleovorans (546 aa)%2C FASTA scores: opt: 1468%2C E(): 0%2C(41.1%25 identity in 538 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD14;inference=protein motif:PROSITE:PS00455;locus_tag=Rv1058;product=Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP43809.1;transl_table=11
AL123456.3	EMBL	gene	1182391	1183455	.	+	.	ID=gene-Rv1059;Name=Rv1059;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1059
AL123456.3	EMBL	CDS	1182391	1183455	.	+	0	ID=cds-CCP43810.1;Parent=gene-Rv1059;Dbxref=EnsemblGenomes-Gn:Rv1059,EnsemblGenomes-Tr:CCP43810,GOA:O53407,InterPro:IPR000846,InterPro:IPR016040,UniProtKB/TrEMBL:O53407,NCBI_GP:CCP43810.1;Name=CCP43810.1;Note=Rv1059%2C (MTV017.12)%2C len: 354 aa. Conserved protein%2Csimilar to Rv0926c|MTCY21C12.20c hypothetical protein from Mycobacterium tuberculosis (358 aa)%2C FASTA scores: opt: 338%2C E(): 1.4e-14%2C (33.1%25 identity in 363 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1059;product=Conserved protein;protein_id=CCP43810.1;transl_table=11
AL123456.3	EMBL	gene	1183508	1183981	.	+	.	ID=gene-Rv1060;Name=Rv1060;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1060
AL123456.3	EMBL	CDS	1183508	1183981	.	+	0	ID=cds-CCP43811.1;Parent=gene-Rv1060;Dbxref=EnsemblGenomes-Gn:Rv1060,EnsemblGenomes-Tr:CCP43811,GOA:O53408,InterPro:IPR019587,InterPro:IPR023393,UniProtKB/TrEMBL:O53408,NCBI_GP:CCP43811.1;Name=CCP43811.1;Note=Rv1060%2C (MTV017.13)%2C len: 157 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1060;product=Unknown protein;protein_id=CCP43811.1;transl_table=11
AL123456.3	EMBL	gene	1184015	1184878	.	+	.	ID=gene-Rv1061;Name=Rv1061;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1061
AL123456.3	EMBL	CDS	1184015	1184878	.	+	0	ID=cds-CCP43812.1;Parent=gene-Rv1061;Dbxref=EnsemblGenomes-Gn:Rv1061,EnsemblGenomes-Tr:CCP43812,InterPro:IPR017932,InterPro:IPR026869,InterPro:IPR029055,UniProtKB/TrEMBL:O53409,NCBI_GP:CCP43812.1;Name=CCP43812.1;Note=Rv1061%2C (MTV017.14)%2C len: 287 aa. Conserved protein%2Csimilar to hypothetical proteins from various bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803 (304 aa)%2CFASTA scores: opt: 245%2C E():1.2e-09%2C (27.1%25 identity in 258 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1061;product=Conserved protein;protein_id=CCP43812.1;transl_table=11
AL123456.3	EMBL	gene	1184883	1185740	.	+	.	ID=gene-Rv1062;Name=Rv1062;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1062
AL123456.3	EMBL	CDS	1184883	1185740	.	+	0	ID=cds-CCP43813.1;Parent=gene-Rv1062;Dbxref=EnsemblGenomes-Gn:Rv1062,EnsemblGenomes-Tr:CCP43813,GOA:O53410,InterPro:IPR002641,InterPro:IPR016035,UniProtKB/TrEMBL:O53410,NCBI_GP:CCP43813.1;Name=CCP43813.1;Note=Rv1062%2C (MTV017.15)%2C len: 285 aa. Conserved hypothetical protein%2C some similarity to AL079356|SC6G9_10 hypothetical protein in Streptomyces coelicolor (289 aa)%2CFASTA scores: opt: 556%2C E(): 1.2e-27%2C (39.0%25 identity in 287 aa overlap)%2C and Z99111|BSUB0008_176 Bacillus subtilis (260aa)%2C FASTA scores: opt: 163%2C E(): 0.0013%2C (27.4%25 identity in 179aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1062;product=Conserved hypothetical protein;protein_id=CCP43813.1;transl_table=11
AL123456.3	EMBL	gene	1185741	1186823	.	-	.	ID=gene-Rv1063c;Name=Rv1063c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1063c
AL123456.3	EMBL	CDS	1185741	1186823	.	-	0	ID=cds-CCP43814.1;Parent=gene-Rv1063c;Dbxref=EnsemblGenomes-Gn:Rv1063c,EnsemblGenomes-Tr:CCP43814,GOA:P9WIY9,InterPro:IPR001423,InterPro:IPR002641,InterPro:IPR016035,NCBI_GP:CCP43814.1;Name=CCP43814.1;Note=Rv1063c%2C (MTV017.16c)%2C len: 360 aa. Conserved hypothetical protein%2C similar to P37053|YCHK_ECOLI hypothetical protein from Escherichia coli (314 aa)%2C FASTA scores: opt: 487%2C E(): 7.2e-23%2C (32.7%25 identity in 321 aa overlap). Also partially similar to Rv3239c|MTCY20B11.14c. Belongs to the UPF0028 (SWS) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1063c;product=Conserved hypothetical protein;protein_id=CCP43814.1;transl_table=11
AL123456.3	EMBL	gene	1186904	1187323	.	-	.	ID=gene-Rv1064c;Name=lpqV;gbkey=Gene;gene=lpqV;gene_biotype=protein_coding;locus_tag=Rv1064c
AL123456.3	EMBL	CDS	1186904	1187323	.	-	0	ID=cds-CCP43815.1;Parent=gene-Rv1064c;Dbxref=EnsemblGenomes-Gn:Rv1064c,EnsemblGenomes-Tr:CCP43815,GOA:P9WK57,InterPro:IPR020377,NCBI_GP:CCP43815.1;Name=CCP43815.1;Note=Rv1064c%2C (MTV017.17c)%2C len: 139 aa. Possible lipoprotein LpqV. Has N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lpqV;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1064c;product=Possible lipoprotein LpqV;protein_id=CCP43815.1;transl_table=11
AL123456.3	EMBL	gene	1187435	1188001	.	+	.	ID=gene-Rv1065;Name=Rv1065;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1065
AL123456.3	EMBL	CDS	1187435	1188001	.	+	0	ID=cds-CCP43816.1;Parent=gene-Rv1065;Dbxref=EnsemblGenomes-Gn:Rv1065,EnsemblGenomes-Tr:CCP43816,GOA:O53413,InterPro:IPR010300,InterPro:IPR011051,InterPro:IPR014710,UniProtKB/TrEMBL:O53413,NCBI_GP:CCP43816.1;Name=CCP43816.1;Note=Rv1065%2C (MTV017.18)%2C len: 188 aa. Conserved hypothetical protein%2C some similarity to AL0209|SC4H8_11 hypothetical protein from Streptomyces coelicolor (182 aa)%2CFASTA scores: opt: 156%2C E(): 0.0011%2C (31.3%25 identity in 195 aa overlap).;gbkey=CDS;locus_tag=Rv1065;product=Conserved hypothetical protein;protein_id=CCP43816.1;transl_table=11
AL123456.3	EMBL	gene	1187998	1188393	.	+	.	ID=gene-Rv1066;Name=Rv1066;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1066
AL123456.3	EMBL	CDS	1187998	1188393	.	+	0	ID=cds-CCP43817.1;Parent=gene-Rv1066;Dbxref=EnsemblGenomes-Gn:Rv1066,EnsemblGenomes-Tr:CCP43817,InterPro:IPR001763,UniProtKB/TrEMBL:O53414,NCBI_GP:CCP43817.1;Name=CCP43817.1;Note=Rv1066%2C (MTV017.19)%2C len: 131 aa. Conserved hypothetical protein%2C strong similarity to AL0209|SC4H8.10 hypothetical protein from Streptomyces coelicolor (132 aa)%2CFASTA scores: opt: 429%2C E(): 5.2e-23%2C (57.1%25 identity in 119 aa overlap).;gbkey=CDS;locus_tag=Rv1066;product=Conserved hypothetical protein;protein_id=CCP43817.1;transl_table=11
AL123456.3	EMBL	gene	1188421	1190424	.	-	.	ID=gene-Rv1067c;Name=PE_PGRS19;gbkey=Gene;gene=PE_PGRS19;gene_biotype=protein_coding;locus_tag=Rv1067c
AL123456.3	EMBL	CDS	1188421	1190424	.	-	0	ID=cds-CCP43818.1;Parent=gene-Rv1067c;Dbxref=EnsemblGenomes-Gn:Rv1067c,EnsemblGenomes-Tr:CCP43818,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FT3,NCBI_GP:CCP43818.1;Name=CCP43818.1;Note=Rv1067c%2C (MTV017.20c)%2C len: 667 aa. PE_PGRS19%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002). Similar to Rv3388|MTV004.46 M. tuberculosis (731 aa)%2C FASTA scores: opt: 2227%2C E(): 0%2C (55.6%25 identity in 710 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1%2C probably fortuitous. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS19;inference=protein motif:PROSITE:PS00583;locus_tag=Rv1067c;product=PE-PGRS family protein PE_PGRS19;protein_id=CCP43818.1;transl_table=11
AL123456.3	EMBL	gene	1190757	1192148	.	-	.	ID=gene-Rv1068c;Name=PE_PGRS20;gbkey=Gene;gene=PE_PGRS20;gene_biotype=protein_coding;locus_tag=Rv1068c
AL123456.3	EMBL	CDS	1190757	1192148	.	-	0	ID=cds-CCP43819.1;Parent=gene-Rv1068c;Dbxref=EnsemblGenomes-Gn:Rv1068c,EnsemblGenomes-Tr:CCP43819,InterPro:IPR000084,NCBI_GP:CCP43819.1;Name=CCP43819.1;Note=Rv1068c%2C (MTV017.21c)%2C len: 463 aa. PE_PGRS20%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002). Similar to AL021897|MTV017_19 Mycobacterium tuberculosis H37Rv (667 aa)%2C FASTA scores: opt: 1875%2C E(): 0%2C (55.0%25 identity in 667 aa overlap).;gbkey=CDS;gene=PE_PGRS20;locus_tag=Rv1068c;product=PE-PGRS family protein PE_PGRS20;protein_id=CCP43819.1;transl_table=11
AL123456.3	EMBL	gene	1192510	1194273	.	-	.	ID=gene-Rv1069c;Name=Rv1069c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1069c
AL123456.3	EMBL	CDS	1192510	1194273	.	-	0	ID=cds-CCP43820.1;Parent=gene-Rv1069c;Dbxref=EnsemblGenomes-Gn:Rv1069c,EnsemblGenomes-Tr:CCP43820,GOA:O53417,InterPro:IPR012037,InterPro:IPR027787,InterPro:IPR027788,UniProtKB/TrEMBL:O53417,NCBI_GP:CCP43820.1;Name=CCP43820.1;Note=Rv1069c%2C (MTV017.22c)%2C len: 587 aa. Conserved protein%2C hydrophobic regions in N-terminal domain. Similar in part to O07136|B1306.04C B1306.04c protein from Mycobacterium leprae (89 aa)%2C FASTA scores: opt: 229%2C E(): 1.3e-07%2C (54.2%25 identity in 72 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1069c;product=Conserved protein;protein_id=CCP43820.1;transl_table=11
AL123456.3	EMBL	gene	1194270	1195043	.	-	.	ID=gene-Rv1070c;Name=echA8;gbkey=Gene;gene=echA8;gene_biotype=protein_coding;locus_tag=Rv1070c
AL123456.3	EMBL	CDS	1194270	1195043	.	-	0	ID=cds-CCP43821.1;Parent=gene-Rv1070c;Dbxref=EnsemblGenomes-Gn:Rv1070c,EnsemblGenomes-Tr:CCP43821,GOA:P9WNN9,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,PDB:3H81,PDB:3PZK,PDB:3Q0G,PDB:3Q0J,PDB:4FJW,NCBI_GP:CCP43821.1;Name=CCP43821.1;Note=Rv1070c%2C (MTV017.23c)%2C len: 257 aa. Probable echA8%2Cenoyl-CoA hydratase%2C equivalent to O07137|B1306.05c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (257 aa)%2C FASTA scores: opt: 1417%2C E(): 0%2C (86.4%25 identity in 257 aa overlap). Also highly similar to others e.g. NP_106219.1|NC_002678 enoyl CoA hydratase from Mesorhizobium loti (257 aa)%3B L39265|RHMRPST_2 enoyl-CoA hydratase from Rhizobium melilotii (257 aa)%2C FASTA scores: opt: 1100%2C E(): 0%2C (66.9%25 identity in 257 aa overlap)%3B AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa)%3B etc. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. Belongs to the enoyl-CoA hydratase/isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA8;inference=protein motif:PROSITE:PS00166;locus_tag=Rv1070c;product=Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43821.1;transl_table=11
AL123456.3	EMBL	gene	1195055	1196092	.	-	.	ID=gene-Rv1071c;Name=echA9;gbkey=Gene;gene=echA9;gene_biotype=protein_coding;locus_tag=Rv1071c
AL123456.3	EMBL	CDS	1195055	1196092	.	-	0	ID=cds-CCP43822.1;Parent=gene-Rv1071c;Dbxref=EnsemblGenomes-Gn:Rv1071c,EnsemblGenomes-Tr:CCP43822,GOA:O53419,InterPro:IPR001753,InterPro:IPR014748,InterPro:IPR029045,UniProtKB/TrEMBL:O53419,NCBI_GP:CCP43822.1;Name=CCP43822.1;Note=Rv1071c%2C (MTV017.24c)%2C len: 345 aa. Possible echA9%2Cenoyl-CoA hydratase%2C equivalent to Y13803|B1306.06c putative enoyl-CoA hydratase/isomerase from Mycobacterium leprae (345 aa)%2C FASTA scores: opt: 1799%2C E(): 0%2C (77.7%25 identity in 345 aa overlap). Also similar to many eukaryotic and prokaryotic enoyl-CoA hydratases e.g. NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (356 aa)%3B NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (350 aa)%3B Q19278 protein similar to enoyl-CoA hydratases from Caenorhabditis elegans (386)%2CFASTA scores: opt: 787%2C E(): 0%2C (38.5%25 identity in 348 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA9;locus_tag=Rv1071c;product=Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43822.1;transl_table=11
AL123456.3	EMBL	gene	1196279	1197115	.	+	.	ID=gene-Rv1072;Name=Rv1072;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1072
AL123456.3	EMBL	CDS	1196279	1197115	.	+	0	ID=cds-CCP43823.1;Parent=gene-Rv1072;Dbxref=EnsemblGenomes-Gn:Rv1072,EnsemblGenomes-Tr:CCP43823,GOA:O53420,InterPro:IPR010539,UniProtKB/TrEMBL:O53420,NCBI_GP:CCP43823.1;Name=CCP43823.1;Note=Rv1072%2C (MTV017.25)%2C len: 278 aa. Probable conserved transmembrane protein%2C equivalent to O07139|B1306.07|Y13803 Protein B1306.07 from Mycobacterium leprae (220 aa)%2C FASTA scores: opt:1032%2C E(): 0%2C (75.0%25 identity in 220 aa overlap)%3B and at the C-terminal end to Q50056|U1740D Mycobacterium leprae (96 aa)%2C FASTA scores: opt: 381%2C E(): 1.2e-18%2C (71.6%25 identity in 81 aa overlap). Similar to Q54192|M80628|STMBLDA_1 transfer RNA-LEU (BLDA) gene and ORF from Streptomyces griseus (293 aa)%2C FASTA scores: opt:558%2C E(): 4.7e-30%2C (41.5%25 identity in 299 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1072;product=Probable conserved transmembrane protein;protein_id=CCP43823.1;transl_table=11
AL123456.3	EMBL	gene	1197231	1198082	.	+	.	ID=gene-Rv1073;Name=Rv1073;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1073
AL123456.3	EMBL	CDS	1197231	1198082	.	+	0	ID=cds-CCP43824.1;Parent=gene-Rv1073;Dbxref=EnsemblGenomes-Gn:Rv1073,EnsemblGenomes-Tr:CCP43824,GOA:O53421,UniProtKB/TrEMBL:O53421,NCBI_GP:CCP43824.1;Name=CCP43824.1;Note=Rv1073%2C (MTV017.26)%2C len: 283 aa. Conserved hypothetical protein%2C similar to several hypothetical mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03 Mycobacterium tuberculosis (339 aa)%2C FASTA scores: opt: 810%2C E(): 0%2C (47.4%25 identity in 272 aa overlap)%3B Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289 aa)%2C FASTA scores: opt: 704%2C E(): 0%2C (44.4%25 identity in 259 aa overlap)%3B and Rv3517%2C etc.%2C and GIR10|AF002133_10 Mycobacterium avium strain GIR10 (346 aa)%2C FASTA scores: opt: 802%2C E(): 0%2C (48.1%25 identity in 270 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1073;product=Conserved hypothetical protein;protein_id=CCP43824.1;transl_table=11
AL123456.3	EMBL	gene	1198156	1199373	.	-	.	ID=gene-Rv1074c;Name=fadA3;gbkey=Gene;gene=fadA3;gene_biotype=protein_coding;locus_tag=Rv1074c
AL123456.3	EMBL	CDS	1198156	1199373	.	-	0	ID=cds-CCP43825.1;Parent=gene-Rv1074c;Dbxref=EnsemblGenomes-Gn:Rv1074c,EnsemblGenomes-Tr:CCP43825,GOA:O53422,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020613,InterPro:IPR020616,InterPro:IPR020617,UniProtKB/TrEMBL:O53422,NCBI_GP:CCP43825.1;Name=CCP43825.1;Note=Rv1074c%2C (MTV017.27c)%2C len: 405 aa. Probable fadA3%2Cbeta-ketoacyl CoA thiolase%2C highly similar to many involved in beta-oxidation e.g. CAB89028.1|AL353870 beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor (395 aa)%3B P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA thiolase from Escherichia coli (401 aa)%2C FASTA scores: opt: 1034%2C E(): 5.4e-56%2C (43.5%25 identity in 416 aa overlap) and X97452 acetyl-CoA acetyltransferase (thiolase) from Escherichia coli (401 aa)%2C FASTA scores: opt: 1043%2C E(): 0%2C(43.4%25 identity in 415 aa overlap)%3B Q43935|CATF_ACICA beta-ketoadipyl CoA thiolase from Acinetobacter calcoaceticus (401 aa)%2C FASTA scores: opt: 992%2C E(): 0%2C(41.5%25 identity in 415 aa overlap)%3B etc. Contains PS00737 Thiolases signature 2%2C and PS00445 FGGY family of carbohydrate kinases signature 2%2C although this is probably fortuitous. Belongs to the thiolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadA3;inference=protein motif:PROSITE:PS00737;locus_tag=Rv1074c;product=Probable beta-ketoacyl CoA thiolase FadA3;protein_id=CCP43825.1;transl_table=11
AL123456.3	EMBL	gene	1199426	1200370	.	-	.	ID=gene-Rv1075c;Name=Rv1075c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1075c
AL123456.3	EMBL	CDS	1199426	1200370	.	-	0	ID=cds-CCP43826.1;Parent=gene-Rv1075c;Dbxref=EnsemblGenomes-Gn:Rv1075c,EnsemblGenomes-Tr:CCP43826,GOA:O53423,InterPro:IPR013831,UniProtKB/TrEMBL:O53423,NCBI_GP:CCP43826.1;Name=CCP43826.1;Note=Rv1075c%2C (MTV017.28c)%2C len: 314 aa. Possibly exported protein%2C as it contains a N-terminal signal sequence%2C hydrophobic domain from aa 7-25. Similar to U15183|MLU15183_2 Mycobacterium leprae cosmid B1740 (106 aa)%2C FASTA scores: opt: 207%2C E(): 1.6e-06%2C (42.6%25 identity in 101 aa overlap). Also weak similarity to many glyceraldehyde-3-phosphate dehydrogenases e.g. Q41595|G3PC_TAXBA Taxus baccata (340 aa)%2C FASTA scores: opt: 147%2C E(): 0.027%2C (27.5%25 identity in 189 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1075c;product=Conserved exported protein;protein_id=CCP43826.1;transl_table=11
AL123456.3	EMBL	gene	1200767	1201660	.	+	.	ID=gene-Rv1076;Name=lipU;gbkey=Gene;gene=lipU;gene_biotype=protein_coding;locus_tag=Rv1076
AL123456.3	EMBL	CDS	1200767	1201660	.	+	0	ID=cds-CCP43827.1;Parent=gene-Rv1076;Dbxref=EnsemblGenomes-Gn:Rv1076,EnsemblGenomes-Tr:CCP43827,GOA:O53424,InterPro:IPR002168,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:O53424,NCBI_GP:CCP43827.1;Name=CCP43827.1;Note=Rv1076%2C (MTV017.29)%2C len: 297 aa. Possible lipU%2Clipase%2C very similar to several Mycobacterium tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c (277 aa)%2C FASTA scores: opt: 1225%2C E(): 0%2C (76.0%25 identity in 246 aa overlap)%3B Rv1426c%2C etc. Also similar to esterases and lipases of around 300 aa e.g. Q44087 esterase precursor from Acinetobacter lwoffii esterase (303)%2C FASTA scores: opt: 427%2C E(): 1.9e-21%2C (32.5%25 identity in 280 aa overlap). Equivalent to AL035159|MLCB1450 _7 Mycobacterium leprae (335 aa)%2C FASTA scores: opt: 1588%2C E(): 0%2C (79.7%25 identity in 296 aa overlap).;gbkey=CDS;gene=lipU;locus_tag=Rv1076;product=Possible lipase LipU;protein_id=CCP43827.1;transl_table=11
AL123456.3	EMBL	gene	1201717	1203111	.	+	.	ID=gene-Rv1077;Name=cbs;gbkey=Gene;gene=cbs;gene_biotype=protein_coding;gene_synonym=cysM2;locus_tag=Rv1077
AL123456.3	EMBL	CDS	1201717	1203111	.	+	0	ID=cds-CCP43828.1;Parent=gene-Rv1077;Dbxref=EnsemblGenomes-Gn:Rv1077,EnsemblGenomes-Tr:CCP43828,GOA:P9WP51,InterPro:IPR000644,InterPro:IPR001926,InterPro:IPR005857,NCBI_GP:CCP43828.1;Name=CCP43828.1;Note=Rv1077%2C (MTV017.30)%2C len: 464 aa. Probable cbs (previously cysM2)%2C cystathionine beta-synthase%2C similar throughout its length to many eukaryotic cystathionine beta-synthases e.g. P32232|CBS_RAT cystathionine beta-synthase (560 aa)%2C FASTA scores: opt: 951%2C E(): 0%2C(40.2%25 identity in 450 aa overlap)%3B also similar in N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK Mycobacterium tuberculosis (310 aa)%2C FASTA scores: opt: 855%2C E(): 0%2C (46.8%25 identity in 314 overlap)%3B and other cysteine synthase proteins e.g. Rv1336%2C Rv0848%2C etc. Contains PS00217 Sugar transport proteins signature 2 probably spurious. Belongs to the cysteine synthase/cystathionine beta-synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cbs;inference=protein motif:PROSITE:PS00217;locus_tag=Rv1077;product=Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450);protein_id=CCP43828.1;transl_table=11
AL123456.3	EMBL	gene	1203313	1204035	.	+	.	ID=gene-Rv1078;Name=pra;gbkey=Gene;gene=pra;gene_biotype=protein_coding;locus_tag=Rv1078
AL123456.3	EMBL	CDS	1203313	1204035	.	+	0	ID=cds-CCP43829.1;Parent=gene-Rv1078;Dbxref=EnsemblGenomes-Gn:Rv1078,EnsemblGenomes-Tr:CCP43829,GOA:P9WIM7,InterPro:IPR010432,NCBI_GP:CCP43829.1;Name=CCP43829.1;Note=Rv1078%2C (MTV017.31)%2C len: 240 aa. Probable pra%2CProline-rich antigen homolog%2C equivalent to X65546|MLPRAG_1 proline rich antigen from Mycobacterium leprae (249 aa)%2CFASTA scores: opt: 1162%2C E(): 3.3e-30%2C (64.8%25 identity in 253 aa overlap). Has potential hydrophobic domains.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pra;locus_tag=Rv1078;product=Probable proline-rich antigen homolog Pra;protein_id=CCP43829.1;transl_table=11
AL123456.3	EMBL	gene	1204067	1205233	.	+	.	ID=gene-Rv1079;Name=metB;gbkey=Gene;gene=metB;gene_biotype=protein_coding;locus_tag=Rv1079
AL123456.3	EMBL	CDS	1204067	1205233	.	+	0	ID=cds-CCP43830.1;Parent=gene-Rv1079;Dbxref=EnsemblGenomes-Gn:Rv1079,EnsemblGenomes-Tr:CCP43830,GOA:P9WGB7,InterPro:IPR000277,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP43830.1;Name=CCP43830.1;Note=Rv1079%2C (MTV017.32)%2C len: 388 aa. metB%2Ccystathionine gamma-synthase (see citation below). P46807|METB_MYCLE cystathionine gamma-synthase from Mycobacterium leprae (388 aa)%2C FASTA scores: opt: 2220%2CE(): 0%2C (87.3%25 identity in 387 aa overlap). Also similar to other Mycobacterium tuberculosis enzymes involved in methionine synthesis e.g. Rv0391 and Rv3340. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. Belongs to the trans-sulfuration enzymes family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metB;inference=protein motif:PROSITE:PS00868;locus_tag=Rv1079;product=Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase);protein_id=CCP43830.1;transl_table=11
AL123456.3	EMBL	gene	1205304	1205798	.	-	.	ID=gene-Rv1080c;Name=greA;gbkey=Gene;gene=greA;gene_biotype=protein_coding;locus_tag=Rv1080c
AL123456.3	EMBL	CDS	1205304	1205798	.	-	0	ID=cds-CCP43831.1;Parent=gene-Rv1080c;Dbxref=EnsemblGenomes-Gn:Rv1080c,EnsemblGenomes-Tr:CCP43831,GOA:P9WMT9,InterPro:IPR001437,InterPro:IPR006359,InterPro:IPR018151,InterPro:IPR022691,InterPro:IPR023459,InterPro:IPR028624,NCBI_GP:CCP43831.1;Name=CCP43831.1;Note=Rv1080c%2C (MTV017.33c)%2C len: 164 aa. Probable greA%2Ctranscription elongation factor G%2C closest to P46808|GREA_MYCLE transcription elongation factor G from Mycobacterium leprae (202 aa)%2C FASTA scores: opt: 1005%2CE(): 0%2C (94.5%25 identity in 164 aa overlap)%3B and similar to many e.g. P21346|GREA_ECOLI from Escherichia coli (158 aa)%2CFASTA scores: opt: 257%2C E(): 5.7e-10%2C (37.2%25 identity in 148 aa overlap)%3B etc. Contains two PS00829 and one PS00830 Prokaryotic transcription elongation factors signatures 1 and 2%2C respectively. Belongs to the GREA/GREB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=greA;inference=protein motif:PROSITE:PS00830;locus_tag=Rv1080c;product=Probable transcription elongation factor GreA (transcript cleavage factor GreA);protein_id=CCP43831.1;transl_table=11
AL123456.3	EMBL	gene	1205984	1206418	.	-	.	ID=gene-Rv1081c;Name=Rv1081c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1081c
AL123456.3	EMBL	CDS	1205984	1206418	.	-	0	ID=cds-CCP43832.1;Parent=gene-Rv1081c;Dbxref=EnsemblGenomes-Gn:Rv1081c,EnsemblGenomes-Tr:CCP43832,InterPro:IPR025443,UniProtKB/TrEMBL:O53429,NCBI_GP:CCP43832.1;Name=CCP43832.1;Note=Rv1081c%2C (MTV017.34c)%2C len: 144 aa. Probable conserved membrane protein%2C with hydrophobic stretch from aa 26 - 48%2C highly similar to NP_302548.1|NC_002677 conserved membrane protein from Mycobacterium leprae. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1081c;product=Probable conserved membrane protein;protein_id=CCP43832.1;transl_table=11
AL123456.3	EMBL	gene	1206520	1207386	.	+	.	ID=gene-Rv1082;Name=mca;gbkey=Gene;gene=mca;gene_biotype=protein_coding;locus_tag=Rv1082
AL123456.3	EMBL	CDS	1206520	1207386	.	+	0	ID=cds-CCP43833.1;Parent=gene-Rv1082;Dbxref=EnsemblGenomes-Gn:Rv1082,EnsemblGenomes-Tr:CCP43833,GOA:P9WJN1,InterPro:IPR003737,InterPro:IPR017811,InterPro:IPR024078,NCBI_GP:CCP43833.1;Name=CCP43833.1;Note=Rv1082%2C (MTV017.35)%2C len: 288 aa. Mca%2C mycothiol conjugate amidase (see citation below)%2C equivalent to NP_302547.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (290 aa)%2C FASTA scores: opt: 1737%2CE(): 0%2C (86.4%25 identity in 287 aa overlap)%3B and similar to Q54358|X79146 lmbE protein from Streptomyces lincolnensis (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins deacetylase from Mycobacterium tuberculosis (303 aa)%2C FASTA scores: opt: 411%2C E(): 9.4e-20%2C (35.8%25 identity in 299 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mca;locus_tag=Rv1082;product=Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase);protein_id=CCP43833.1;transl_table=11
AL123456.3	EMBL	gene	1207383	1207649	.	+	.	ID=gene-Rv1083;Name=Rv1083;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1083
AL123456.3	EMBL	CDS	1207383	1207649	.	+	0	ID=cds-CCP43834.1;Parent=gene-Rv1083;Dbxref=EnsemblGenomes-Gn:Rv1083,EnsemblGenomes-Tr:CCP43834,UniProtKB/TrEMBL:O53431,NCBI_GP:CCP43834.1;Name=CCP43834.1;Note=Rv1083%2C (MTV017.36)%2C len: 88 aa. Conserved hypothetical protein%2C similar to U15183|MLU15183_9 hypothetical protein from Mycobacterium leprae (167 aa)%2CFASTA scores: opt: 332%2C E(): 1.2e-13%2C (58.4%25 identity in 101 aa overlap). Hydrophobic domain aa 25-43. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1083;product=Conserved hypothetical protein;protein_id=CCP43834.1;transl_table=11
AL123456.3	EMBL	gene	1207636	1209657	.	+	.	ID=gene-Rv1084;Name=Rv1084;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1084
AL123456.3	EMBL	CDS	1207636	1209657	.	+	0	ID=cds-CCP43835.1;Parent=gene-Rv1084;Dbxref=EnsemblGenomes-Gn:Rv1084,EnsemblGenomes-Tr:CCP43835,GOA:O53432,InterPro:IPR004879,InterPro:IPR008928,InterPro:IPR012336,InterPro:IPR012341,InterPro:IPR024705,UniProtKB/TrEMBL:O53432,NCBI_GP:CCP43835.1;Name=CCP43835.1;Note=Rv1084%2C (MTV017.37)%2C len: 673 aa. Conserved protein%2Csimilar to P37512|YYAL_BACSU hypothetical protein from Bacillus subtilis (689 aa)%2C FASTA scores: opt: 1063%2C E() : 0%2C (36.5%25 identity in 696 aa overlap)%3B AE0009|AE000983_10 Archaeoglobus fulgidus section 1 (642 aa)%2C FASTA scores: opt: 1018%2C E(): 0%2C (37.2%25 identity in 600 aa overlap). Also similar to AE001938|AE001938_9 Deinococcus radiodurans (690 aa)%2C FASTA scores: opt: 1097%2C E(): 0%2C (41.6%25 identity in 694 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1084;product=Conserved protein;protein_id=CCP43835.1;transl_table=11
AL123456.3	EMBL	gene	1209756	1210484	.	-	.	ID=gene-Rv1085c;Name=Rv1085c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1085c
AL123456.3	EMBL	CDS	1209756	1210484	.	-	0	ID=cds-CCP43836.1;Parent=gene-Rv1085c;Dbxref=EnsemblGenomes-Gn:Rv1085c,EnsemblGenomes-Tr:CCP43836,GOA:P9WFN7,InterPro:IPR004254,InterPro:IPR005744,NCBI_GP:CCP43836.1;Name=CCP43836.1;Note=Rv1085c%2C (MTV017.38c)%2C len: 242 aa. Possible hemolysin-like protein%2C integral membrane protein%2C similar to many hemolysins%2C and hypothetical proteins e.g. U28375|ECU28375_49 Hypothetical protein from Escherichia coli (219 aa)%2C FASTA scores: opt: 308%2C E(): 7.5e-15%2C (30.6%25 identity in 180 aa overlap)%3B AE0011|HIAE001124_2 Hypothetical protein from Borrelia burgdorferi (233 aa)%2CFASTA scores: opt: 305%2C E(): 1.3e-14%2C (25.6%25 identity in 203 aa overlap). Also weakly similar to HLY3_BACCE|P54176 haemolysin from Bacillus cereus (219 aa)%2C FASTA scores: opt: 247%2C E(): 8.7e-12%2C (27.5%25 identity in 171 aa overlap). Also similar to AE002027|AE002027_8 probable hemolysin from Deinococcus radiodurans (219 aa)%2C FASTA scores: opt: 354%2CE(): 1.8e-16%2C (31.1%25 identity in 219 aa overlap).;gbkey=CDS;locus_tag=Rv1085c;product=Possible hemolysin-like protein;protein_id=CCP43836.1;transl_table=11
AL123456.3	EMBL	gene	1210595	1211383	.	+	.	ID=gene-Rv1086;Name=Rv1086;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1086
AL123456.3	EMBL	CDS	1210595	1211383	.	+	0	ID=cds-CCP43837.1;Parent=gene-Rv1086;Dbxref=EnsemblGenomes-Gn:Rv1086,EnsemblGenomes-Tr:CCP43837,GOA:P9WFF5,InterPro:IPR001441,InterPro:IPR018520,PDB:2VFW,PDB:2VG0,PDB:2VG1,NCBI_GP:CCP43837.1;Name=CCP43837.1;Note=Rv1086%2C (MTV017.39)%2C len: 262 aa. Short (C15) chain Z-isoprenyl diphosphate synthase (see citations below)%2Cequivalent to NP_302598.1|NC_002677 possible undecaprenyl pyrophosphate synthetase from Mycobacterium leprae (262 aa)%2C similar to many hypothetical proteins and several potential members of the upp synthase family e.g. NP_296167.1|NC_001263 undecaprenyl diphosphate synthase from Deinococcus radiodurans (339 aa)%3B P20182|YT14_STRFR Hypothetical protein from Streptomyces fradiae (259 aa)%2CFASTA scores: opt: 840%2C E(): 0%2C (51.0%25 identity in 259 aa overlap)%3B and P38118|YARF_CORGL Hypothetical protein from Corynebacterium glutamicicum (234 aa)%2C FASTA scores: opt: 729%2C E(): 0%2C (56.0%25 identity in 209 aa overlap)%3B etc. Also similar to Rv2361c|MTCY27.19 (296 aa) (35.6%25 identity in 233 aa overlap). Contains PS01066 Uncharacterized protein family UPF0015 signature. Seems to belong to the UPP synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01066;locus_tag=Rv1086;product=Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase);protein_id=CCP43837.1;transl_table=11
AL123456.3	EMBL	gene	1211560	1213863	.	+	.	ID=gene-Rv1087;Name=PE_PGRS21;gbkey=Gene;gene=PE_PGRS21;gene_biotype=protein_coding;locus_tag=Rv1087
AL123456.3	EMBL	CDS	1211560	1213863	.	+	0	ID=cds-CCP43838.1;Parent=gene-Rv1087;Dbxref=EnsemblGenomes-Gn:Rv1087,EnsemblGenomes-Tr:CCP43838,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FT0,NCBI_GP:CCP43838.1;Name=CCP43838.1;Note=Rv1087%2C (MTV017.40)%2C len: 767 aa. PE_PGRS21%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below). Similar to Rv1090|AL021897|MTV017_43 Mycobacterium tuberculosis H37Rv (853 aa)%2C FASTA scores: opt: 2819%2C E(): 0%2C (59.8%25 identity in 860 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1 near C -terminus. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS21;inference=protein motif:PROSITE:PS00583;locus_tag=Rv1087;product=PE-PGRS family protein PE_PGRS21;protein_id=CCP43838.1;transl_table=11
AL123456.3	EMBL	gene	1214040	1214360	.	+	.	ID=gene-Rv1087A;Name=Rv1087A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1087A
AL123456.3	EMBL	CDS	1214040	1214360	.	+	0	ID=cds-CCP43839.1;Parent=gene-Rv1087A;Dbxref=EnsemblGenomes-Gn:Rv1087A,EnsemblGenomes-Tr:CCP43839,GOA:L7N654,InterPro:IPR001441,UniProtKB/TrEMBL:L7N654,NCBI_GP:CCP43839.1;Name=CCP43839.1;Note=Rv1087A%2C len: 106 aa (fragment). Conserved hypothetical protein%2C highly similar to C-terminus of near ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 short (C15) chain Z-isoprenyl diphosphate synthase from Mycobacterium tuberculosis (262 aa)%2C FASTA scores: opt: 200%2C E(): 1.1e-06%2C (57.9%25 identity in 76 aa overlap).;gbkey=CDS;locus_tag=Rv1087A;product=Conserved hypothetical protein;protein_id=CCP43839.1;transl_table=11
AL123456.3	EMBL	gene	1214513	1214947	.	+	.	ID=gene-Rv1088;Name=PE9;gbkey=Gene;gene=PE9;gene_biotype=protein_coding;locus_tag=Rv1088
AL123456.3	EMBL	CDS	1214513	1214947	.	+	0	ID=cds-CCP43840.1;Parent=gene-Rv1088;Dbxref=EnsemblGenomes-Gn:Rv1088,EnsemblGenomes-Tr:CCP43840,GOA:Q79FS8,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FS8,NCBI_GP:CCP43840.1;Name=CCP43840.1;Note=Rv1088%2C (MTV017.41)%2C len: 144 aa. PE9%2C Member of Mycobacterium tuberculosis PE family (see citation below)%2Csimilar to many others e.g. Z96071|MTCI418B_6 Mycobacterium tuberculosis cosmid (487 aa)%2C FASTA scores: opt: 318%2C E(): 7.3e-14%2C (60.9%25 identity in 87 aa overlap) - except it appears to be frameshifted around codon 84. No error to account for frameshift could be found.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE9;locus_tag=Rv1088;product=PE family protein PE9;protein_id=CCP43840.1;transl_table=11
AL123456.3	EMBL	gene	1214769	1215131	.	+	.	ID=gene-Rv1089;Name=PE10;gbkey=Gene;gene=PE10;gene_biotype=protein_coding;locus_tag=Rv1089;partial=true;start_range=.,1214769
AL123456.3	EMBL	CDS	1214769	1215131	.	+	0	ID=cds-CCP43841.1;Parent=gene-Rv1089;Dbxref=EnsemblGenomes-Gn:Rv1089,EnsemblGenomes-Tr:CCP43841,UniProtKB/TrEMBL:L0T5T4,NCBI_GP:CCP43841.1;Name=CCP43841.1;Note=Rv1089%2C (MTV017.42)%2C len: 120 aa. PE10%2C Member of the Mycobacterium tuberculosis PE family of glycine-rich proteins (see citation below). Partial ORF that appears to be frameshifted continuation of Rv1088|MTV017.41. Sequence has been checked and appears correct. Similar to Z95555|MTCY06F7_4 Mycobacterium tuberculosis cosmid (401 aa)%2C FASTA scores: opt:126%2C E(): 2%2C (29.6%25 identity in 125 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=PE10;locus_tag=Rv1089;partial=true;product=PE family protein PE10;protein_id=CCP43841.1;start_range=.,1214769;transl_table=11
AL123456.3	EMBL	gene	1215517	1215621	.	+	.	ID=gene-Rv1089A;Name=celA2a;gbkey=Gene;gene=celA2a;gene_biotype=protein_coding;locus_tag=Rv1089A
AL123456.3	EMBL	CDS	1215517	1215621	.	+	0	ID=cds-CCP43842.1;Parent=gene-Rv1089A;Dbxref=EnsemblGenomes-Gn:Rv1089A,EnsemblGenomes-Tr:CCP43842,UniProtKB/TrEMBL:Q79FS6,NCBI_GP:CCP43842.1;Name=CCP43842.1;Note=Rv1089A%2C len: 34 aa. Probable celA2a%2C first part of cellulase (endoglucanase)%2C similar to N-terminus of others. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=celA2a;locus_tag=Rv1089A;product=Probable cellulase CelA2a (endo-1%2C4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase);protein_id=CCP43842.1;transl_table=11
AL123456.3	EMBL	gene	1215599	1216054	.	+	.	ID=gene-Rv1090;Name=celA2b;gbkey=Gene;gene=celA2b;gene_biotype=protein_coding;locus_tag=Rv1090
AL123456.3	EMBL	CDS	1215599	1216054	.	+	0	ID=cds-CCP43843.1;Parent=gene-Rv1090;Dbxref=EnsemblGenomes-Gn:Rv1090,EnsemblGenomes-Tr:CCP43843,GOA:O53438,InterPro:IPR002594,InterPro:IPR013319,InterPro:IPR013320,UniProtKB/TrEMBL:O53438,NCBI_GP:CCP43843.1;Name=CCP43843.1;Note=Rv1090%2C (MTV017.43)%2C len: 151 aa. Probable celA2b%2Csecond part of cellulase (endoglucanase)%2C similar to C-terminus of others e.g. O08468 cellulase CEL2 from Streptomyces halstedi (377 aa)%2C FASTA scores: opt: 554%2CE(): 1.2e-30%2C (52.0%25 identity in 152 aa overlap)%3B etc. Gene appears to have been inactivated by frameshift mutations but no errors could be found that would account for this. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=celA2b;locus_tag=Rv1090;product=Probable cellulase CelA2b (endo-1%2C4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase);protein_id=CCP43843.1;transl_table=11
AL123456.3	EMBL	gene	1216469	1219030	.	+	.	ID=gene-Rv1091;Name=PE_PGRS22;gbkey=Gene;gene=PE_PGRS22;gene_biotype=protein_coding;locus_tag=Rv1091
AL123456.3	EMBL	CDS	1216469	1219030	.	+	0	ID=cds-CCP43844.1;Parent=gene-Rv1091;Dbxref=EnsemblGenomes-Gn:Rv1091,EnsemblGenomes-Tr:CCP43844,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FS5,NCBI_GP:CCP43844.1;Name=CCP43844.1;Note=Rv1091%2C (MTV017.44)%2C len: 853 aa. PE_PGRS22%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below). Similar to Rv1087|AL021897|MTV017_39 Mycobacterium tuberculosis H37Rv (767 aa)%2C FASTA scores: opt: 2819%2C E(): 0%2C (60.0%25 identity in 860 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS22;locus_tag=Rv1091;product=PE-PGRS family protein PE_PGRS22;protein_id=CCP43844.1;transl_table=11
AL123456.3	EMBL	gene	1219248	1220186	.	-	.	ID=gene-Rv1092c;Name=coaA;gbkey=Gene;gene=coaA;gene_biotype=protein_coding;locus_tag=Rv1092c
AL123456.3	EMBL	CDS	1219248	1220186	.	-	0	ID=cds-CCP43845.1;Parent=gene-Rv1092c;Dbxref=EnsemblGenomes-Gn:Rv1092c,EnsemblGenomes-Tr:CCP43845,GOA:P9WPA7,InterPro:IPR004566,InterPro:IPR006083,InterPro:IPR027417,PDB:2GES,PDB:2GET,PDB:2GEU,PDB:2GEV,PDB:2ZS7,PDB:2ZS8,PDB:2ZS9,PDB:2ZSA,PDB:2ZSB,PDB:2ZSD,PDB:2ZSE,PDB:2ZSF,PDB:3AEZ,PDB:3AF0,PDB:3AF1,PDB:3AF2,PDB:3AF3,PDB:3AF4,PDB:3AVO,PDB:3AVP,PDB:3AVQ,PDB:4BFS,PDB:4BFT,PDB:4BFU,PDB:4BFV,PDB:4BFW,PDB:4BFX,PDB:4BFY,PDB:4BFZ,NCBI_GP:CCP43845.1;Name=CCP43845.1;Note=Rv1092c%2C (MTV017.45c)%2C len: 312 aa. Probable coaA%2Cpantothenate kinase%2C similar to many e.g. P15044|COAA_ECOLI Escherichia coli (316 aa)%2C FASTA scores :opt: 1079%2C E(): 0%2C(52.7%25 identity in 311 aa overlap). Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae (312 aa) (93.6%25 identity in 312 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the pantothenate kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=coaA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1092c;product=Probable pantothenate kinase CoaA (pantothenic acid kinase);protein_id=CCP43845.1;transl_table=11
AL123456.3	EMBL	gene	1220388	1220487	.	-	.	ID=gene-MTS0858;Name=MTS0858;gbkey=Gene;gene=MTS0858;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1220388	1220487	.	-	.	ID=rna-MTS0858;Parent=gene-MTS0858;Note=MTS0858%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C ends not mapped%2C ~~100 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS0858;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1220388	1220487	.	-	.	ID=exon-MTS0858-1;Parent=rna-MTS0858;Note=MTS0858%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C ends not mapped%2C ~~100 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS0858;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1220574	1221854	.	+	.	ID=gene-Rv1093;Name=glyA1;gbkey=Gene;gene=glyA1;gene_biotype=protein_coding;gene_synonym=glyA;locus_tag=Rv1093
AL123456.3	EMBL	CDS	1220574	1221854	.	+	0	ID=cds-CCP43846.1;Parent=gene-Rv1093;Dbxref=EnsemblGenomes-Gn:Rv1093,EnsemblGenomes-Tr:CCP43846,GOA:P9WGI9,InterPro:IPR001085,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR019798,PDB:1LXB,PDB:3H7F,NCBI_GP:CCP43846.1;Name=CCP43846.1;Note=Rv1093%2C (MTV017.46)%2C len: 426 aa. glyA1%2C serine hydroxymethyltransferase 1%2C equivalent to AL049491|MLCB1222_16 from Mycobacterium leprae (426 aa)%2CFASTA score: (89.9 %25 identity in 426 aa overlap). Also similar to many e.g. P34895|GLYA_HYPME hyphomicrobium methylovorum (434 aa)%2C FASTA scores: opt: 1492%2C E(): 0%2C(56.8%25 identity in 419 aa overlap)%3B etc. Belongs to the ShmT family. Note that previously known as glyA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glyA1;locus_tag=Rv1093;product=Serine hydroxymethyltransferase 1 GlyA1;protein_id=CCP43846.1;transl_table=11
AL123456.3	EMBL	gene	1221959	1222786	.	+	.	ID=gene-Rv1094;Name=desA2;gbkey=Gene;gene=desA2;gene_biotype=protein_coding;locus_tag=Rv1094
AL123456.3	EMBL	CDS	1221959	1222786	.	+	0	ID=cds-CCP43847.1;Parent=gene-Rv1094;Dbxref=EnsemblGenomes-Gn:Rv1094,EnsemblGenomes-Tr:CCP43847,GOA:P9WNZ5,InterPro:IPR005067,InterPro:IPR009078,InterPro:IPR012348,PDB:1ZA0,NCBI_GP:CCP43847.1;Name=CCP43847.1;Note=Rv1094%2C (MTV017.47)%2C len: 275 aa. Possible desA2%2Cacyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase)%2C equivalent to AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa)%2C FASTA score: (78.1%25 identity in 274 aa overlap). Also weakly similar to plant stearoyl-acyl carrier protein desaturases%2C and very similar to U49839|MTV043.16C|Rv0824c enzyme desA1 from Mycobacterium tuberculosis (338 aa)%2C FASTA scores: opt: 525%2C E(): 8.5e-30%2C (32.2%25 identity in 270 aa overlap)%3B and to U15182|MLU15182_32 acyl-carrier protein desaturase precursor from Mycobacterium leprae (338 aa)%2C FASTA scores: opt: 506%2C E(): 1.9e-28%2C (34.1%25 identity in 261 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=desA2;locus_tag=Rv1094;product=Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase);protein_id=CCP43847.1;transl_table=11
AL123456.3	EMBL	gene	1222997	1224298	.	+	.	ID=gene-Rv1095;Name=phoH2;gbkey=Gene;gene=phoH2;gene_biotype=protein_coding;locus_tag=Rv1095
AL123456.3	EMBL	CDS	1222997	1224298	.	+	0	ID=cds-CCP43848.1;Parent=gene-Rv1095;Dbxref=EnsemblGenomes-Gn:Rv1095,EnsemblGenomes-Tr:CCP43848,GOA:O53443,InterPro:IPR002716,InterPro:IPR003714,InterPro:IPR027417,InterPro:IPR029060,UniProtKB/TrEMBL:O53443,NCBI_GP:CCP43848.1;Name=CCP43848.1;Note=Rv1095%2C (MTV017.48)%2C len: 433 aa. Probable phoH2%2CphoH-like protein (phosphate starvation-induced protein)%2Cprobably ATP-binding protein. Equivalent to AL049491 MLCB1222_14 Mycobacterium leprae (433 aa) (92.8%25 identity in 432 aa overlap). Similar to many proteins described as PhoH-like e.g. Z97025|BSZ97025_12 Bacillus subtilis (442 aa)%2C FASTA scores: opt: 605%2C E(): 0%2C (40.1%25 identity in 444 aa overlap)%3B or Mycobacterium tuberculosis Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352 aa)%2C FASTA scores: opt: 390%2C E(): 4e-19%2C (31.5%25 identity in 241 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the PhoH family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=phoH2;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1095;product=Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH);protein_id=CCP43848.1;transl_table=11
AL123456.3	EMBL	gene	1224385	1225260	.	+	.	ID=gene-Rv1096;Name=Rv1096;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1096
AL123456.3	EMBL	CDS	1224385	1225260	.	+	0	ID=cds-CCP43849.1;Parent=gene-Rv1096;Dbxref=EnsemblGenomes-Gn:Rv1096,EnsemblGenomes-Tr:CCP43849,GOA:O53444,InterPro:IPR002509,InterPro:IPR011330,UniProtKB/TrEMBL:O53444,NCBI_GP:CCP43849.1;Name=CCP43849.1;Note=Rv1096%2C (MTV017.49)%2C len: 291 aa. Possible glycosyl hydrolase%2C possibly deacetylase or esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3%25 identity in 289 aa overlap). Similar at the C-terminus to enzymes involved in carbohydrate degradation including Z99110|BSUB0007_92 endo-1%2C4-beta-xylanase homolog yjeA from Bacillus subtilis (467 aa)%2C FASTA scores: opt: 418%2C E(): 2.6e-17%2C (38.6%25 identity in 184 aa overlap)%3B M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces lividans (335 aa)%2C FASTA scores: opt: 371%2C E(): 1.1e-14%2C(31.6%25 identity in 237 aa overlap)%3B NP_345933.1|NC_003028 peptidoglycan N-acetylglucosamine deacetylase a from Streptococcus pneumoniae (463 aa)%3B etc. Has possible N-terminal signal sequence with TMhelix at aa 13-31.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1096;product=Possible glycosyl hydrolase;protein_id=CCP43849.1;transl_table=11
AL123456.3	EMBL	gene	1225263	1226144	.	-	.	ID=gene-Rv1097c;Name=Rv1097c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1097c
AL123456.3	EMBL	CDS	1225263	1226144	.	-	0	ID=cds-CCP43850.1;Parent=gene-Rv1097c;Dbxref=EnsemblGenomes-Gn:Rv1097c,EnsemblGenomes-Tr:CCP43850,GOA:O53445,UniProtKB/TrEMBL:O53445,NCBI_GP:CCP43850.1;Name=CCP43850.1;Note=Rv1097c%2C (MTV017.50c)%2C len: 293 aa. Probable membrane Gly-%2C Pro-rich protein%2C similar to Mycobacterium tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa)%2C FASTA scores: opt: 219%2C E(): 0.023%2C (30.5%25 identity in 266 aa overlap)%3B and Rv2507. Contains potential membrane spanning region (aa ~~68-92).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1097c;product=Probable membrane glycine and proline rich protein;protein_id=CCP43850.1;transl_table=11
AL123456.3	EMBL	gene	1226141	1227565	.	-	.	ID=gene-Rv1098c;Name=fum;gbkey=Gene;gene=fum;gene_biotype=protein_coding;locus_tag=Rv1098c
AL123456.3	EMBL	CDS	1226141	1227565	.	-	0	ID=cds-CCP43851.1;Parent=gene-Rv1098c;Dbxref=EnsemblGenomes-Gn:Rv1098c,EnsemblGenomes-Tr:CCP43851,GOA:P9WN93,InterPro:IPR000362,InterPro:IPR005677,InterPro:IPR008948,InterPro:IPR018951,InterPro:IPR020557,InterPro:IPR022761,InterPro:IPR024083,PDB:3NO9,PDB:4ADL,PDB:4ADM,PDB:4APA,PDB:4APB,NCBI_GP:CCP43851.1;Name=CCP43851.1;Note=Rv1098c%2C (MTV017.51c)%2C len: 474 aa. Probable fum%2Cfumarase. Equivalent to AL049491|MLCB1222_11 Mycobacterium leprae (474 aa) (89.5 %25 identity in 467 aa overlap). Similar to many e.g. P14408|FUMH_RAT fumarate hydratase%2Cmitochondrial precursor from Rattus norvegicus (507 aa)%2CFASTA scores: opt: 1427%2C E(): 0%2C (52.3%25 identity in 461 aa overlap)%3B and P05042|FUMC_ECOLI Fumarate hydratase class II from Escherichia coli (467 aa)%2C FASTA scores: opt: 1355%2CE(): 0%2C (50.2%25 identity in 444 aa overlap). Contains PS00163 Fumarate lyases signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fum;inference=protein motif:PROSITE:PS00163;locus_tag=Rv1098c;product=Probable fumarase Fum (fumarate hydratase);protein_id=CCP43851.1;transl_table=11
AL123456.3	EMBL	gene	1227596	1228684	.	-	.	ID=gene-Rv1099c;Name=glpX;gbkey=Gene;gene=glpX;gene_biotype=protein_coding;locus_tag=Rv1099c
AL123456.3	EMBL	CDS	1227596	1228684	.	-	0	ID=cds-CCP43852.1;Parent=gene-Rv1099c;Dbxref=EnsemblGenomes-Gn:Rv1099c,EnsemblGenomes-Tr:CCP43852,GOA:P9WN21,InterPro:IPR004464,NCBI_GP:CCP43852.1;Name=CCP43852.1;Note=Rv1099c%2C (MTV017.52c)%2C len: 362 aa. glpX%2C class II fructose 1%2C6-bisphosphatase (See Movahedzadeh et al.%2C2004)%2C highly similar to P44811|GLPX_HAEIN GLPX protein homolog (believed to be involved in glycerol metabolism) (333 aa)%2C FASTA scores: opt: 763%2C E():0%2C (46.2%25 identity in 327 aa overlap)%3B and Q03224|YWJI_BACSU hypothetical protein from Bacillus subtilis (321aa)%2C FASTA scores: opt: 1092%2CE(): 0%2C (52.1%25 identity in 313 aa overlap). Equivalent to AL049491|MLCB1222_10 Mycobacterium leprae (355 aa)%2C (93.0%25 identity in 328 aa overlap). N-terminus extended since first submission (previously 328 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glpX;locus_tag=Rv1099c;product=Fructose 1%2C6-bisphosphatase GlpX;protein_id=CCP43852.1;transl_table=11
AL123456.3	EMBL	gene	1228683	1229384	.	+	.	ID=gene-Rv1100;Name=Rv1100;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1100
AL123456.3	EMBL	CDS	1228683	1229384	.	+	0	ID=cds-CCP43853.1;Parent=gene-Rv1100;Dbxref=EnsemblGenomes-Gn:Rv1100,EnsemblGenomes-Tr:CCP43853,GOA:O53448,InterPro:IPR025339,UniProtKB/TrEMBL:O53448,NCBI_GP:CCP43853.1;Name=CCP43853.1;Note=Rv1100%2C (MTV017.53)%2C len: 233 aa. Conserved protein%2Cslightly similar to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa)%2C FASTA scores: opt: 122%2C E(): 6.9%2C (27.4%25 identity in 135 aa overlap). Equivalent to AL049491|MLCB1222_9 Mycobacterium leprae (257 aa) (63.8%25 identity in 257 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1100;product=Conserved protein;protein_id=CCP43853.1;transl_table=11
AL123456.3	EMBL	gene	1229391	1230548	.	-	.	ID=gene-Rv1101c;Name=Rv1101c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1101c
AL123456.3	EMBL	CDS	1229391	1230548	.	-	0	ID=cds-CCP43854.1;Parent=gene-Rv1101c;Dbxref=EnsemblGenomes-Gn:Rv1101c,EnsemblGenomes-Tr:CCP43854,GOA:P9WFM3,InterPro:IPR002549,NCBI_GP:CCP43854.1;Name=CCP43854.1;Note=Rv1101c%2C (MTV017.54c)%2C len: 385 aa. Conserved membrane protein%2C shows some similarity to other bacterial proteins e.g. P77406|PERM_ECOLI putative permease perm from Escherichia coli (353 aa)%2C FASTA scores: opt: 287%2C E(): 8.8e-12%2C (24.9%25 identity in 349 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1101c;product=Conserved membrane protein;protein_id=CCP43854.1;transl_table=11
AL123456.3	EMBL	gene	1230660	1230971	.	-	.	ID=gene-Rv1102c;Name=mazF3;gbkey=Gene;gene=mazF3;gene_biotype=protein_coding;gene_synonym=mt6;locus_tag=Rv1102c
AL123456.3	EMBL	CDS	1230660	1230971	.	-	0	ID=cds-CCP43855.1;Parent=gene-Rv1102c;Dbxref=EnsemblGenomes-Gn:Rv1102c,EnsemblGenomes-Tr:CCP43855,GOA:P9WIH9,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP43855.1;Name=CCP43855.1;Note=Rv1102c%2C (MTV017.55c)%2C len: 103 aa. MazF3%2C toxin%2Cpart of toxin-antitoxin (TA) operon with Rv1103c (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%2C similar to Mycobacterium tuberculosis hypothetical protens e.g. Rv1942c|MTCY9F9_22 (109 aa)%2C FASTA scores: opt: 158%2C E(): 3.6e-05%2C (33.3%25 identity in 93 aa overlap)%3B Rv0659c|MTCI376_17 (102aa)%2C opt: 140%2C E(): 0.00072%2C (40.6%25 identity in 69aa overlap)%3B and Rv1495.;gbkey=CDS;gene=mazF3;locus_tag=Rv1102c;product=Toxin MazF3;protein_id=CCP43855.1;transl_table=11
AL123456.3	EMBL	gene	1230971	1231291	.	-	.	ID=gene-Rv1103c;Name=mazE3;gbkey=Gene;gene=mazE3;gene_biotype=protein_coding;locus_tag=Rv1103c
AL123456.3	EMBL	CDS	1230971	1231291	.	-	0	ID=cds-CCP43856.1;Parent=gene-Rv1103c;Dbxref=EnsemblGenomes-Gn:Rv1103c,EnsemblGenomes-Tr:CCP43856,GOA:O53451,NCBI_GP:CCP43856.1;Name=CCP43856.1;Note=Rv1103c%2C (MTV017.56c)%2C len: 106 aa. Possible mazE3%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1102c (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006). Note that Zhu et al.%2C 2006 identifies a different amino acid sequence as the possible antitoxin to Rv1102c. Similar to part of Mycobacterium tuberculosis hypothetical protein Rv2472|AL021246|MTV008_27 Mycobacterium tuberculosis (97 aa)%2C FASTA score: opt: 135%2C E(): 0.0091%2C (45.8%25 identity in 72 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mazE3;locus_tag=Rv1103c;product=Possible antitoxin MazE3;protein_id=CCP43856.1;transl_table=11
AL123456.3	EMBL	gene	1231301	1231990	.	+	.	ID=gene-Rv1104;Name=Rv1104;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1104
AL123456.3	EMBL	CDS	1231301	1231990	.	+	0	ID=cds-CCP43857.1;Parent=gene-Rv1104;Dbxref=EnsemblGenomes-Gn:Rv1104,EnsemblGenomes-Tr:CCP43857,InterPro:IPR002018,InterPro:IPR029058,UniProtKB/TrEMBL:O53452,NCBI_GP:CCP43857.1;Name=CCP43857.1;Note=Rv1104%2C (MTV017.57)%2C len: 229 aa. Possible para-nitrobenzyl esterase (fragment%3B possibly first part) . Similar to the N-terminal domain of many e.g. P37967|PNBA_BACSU Bacillus subtilis (489 aa)%2C FASTA scores: opt: 715%2C E(): 0%2C (53.4%25 identity in 191 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing in MTV017.58|Rv1105.;gbkey=CDS;locus_tag=Rv1104;product=Possible para-nitrobenzyl esterase (fragment);protein_id=CCP43857.1;transl_table=11
AL123456.3	EMBL	gene	1232311	1232826	.	+	.	ID=gene-Rv1105;Name=Rv1105;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1105
AL123456.3	EMBL	CDS	1232311	1232826	.	+	0	ID=cds-CCP43858.1;Parent=gene-Rv1105;Dbxref=EnsemblGenomes-Gn:Rv1105,EnsemblGenomes-Tr:CCP43858,InterPro:IPR002018,InterPro:IPR029058,UniProtKB/TrEMBL:O53453,NCBI_GP:CCP43858.1;Name=CCP43858.1;Note=Rv1105%2C (MTV017.58)%2C len: 171 aa. Possible para-nitrobenzyl esterase (fragment%3B possibly second part) . Similar to C-terminal domain of many e.g. P71048 para-nitrobenzyl esterase from Bacillus subtilis (489 aa)%2CFASTA scores: opt: 248%2C E(): 2.7e-10%2C (32.3%25 identity in 167 aa overlap). Gene may be inactivated as a frameshift is required to obtain a product continuing from MTV017.57|Rv1104. Start changed since first submission.;gbkey=CDS;locus_tag=Rv1105;product=Possible para-nitrobenzyl esterase (fragment);protein_id=CCP43858.1;transl_table=11
AL123456.3	EMBL	gene	1232844	1233956	.	-	.	ID=gene-Rv1106c;Name=Rv1106c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1106c
AL123456.3	EMBL	CDS	1232844	1233956	.	-	0	ID=cds-CCP43859.1;Parent=gene-Rv1106c;Dbxref=EnsemblGenomes-Gn:Rv1106c,EnsemblGenomes-Tr:CCP43859,GOA:P9WQP7,InterPro:IPR002225,InterPro:IPR016040,NCBI_GP:CCP43859.1;Name=CCP43859.1;Note=Rv1106c%2C (MTV017.59c)%2C len: 370 aa. 3-beta-hydroxysteroid dehydrogenase (see Yang et al.%2C2007). Equivalent to AL049491|MLCB1222_7 Mycobacterium leprae (376 aa) (75.5%25 identity in 375 aa overlap). Highly similar to Q03704 NAD(P)-dependent cholesterol dehydrogenase from Nocardia sp. (364 aa)%2C FASTA scores: opt: 1789%2C E(): 0%2C (74.5%25 identity in 361 aa overlap). Also similar to U32426|MCU32426_1 3-beta-hydroxy-Delta5-steroid dehydrogenase from Molluscum contagiosum virus (354 aa)%2CFASTA scores: opt: 432%2C E(): 1.7e-22%2C (34.6%25 identity in 347 aa overlap). Also similar to series of Mycobacterium tuberculosis hypothetical proteins described as sugar epimerases or dehydratases e.g. Rv3634c%2C Rv3784%2C Rv3464%2Cetc. The transcription of this CDS seems to be activated specifically in host granulomas (see Ramakrishnan et al.%2C2000).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1106c;product=3-beta-hydroxysteroid dehydrogenase;protein_id=CCP43859.1;transl_table=11
AL123456.3	EMBL	gene	1233966	1234223	.	-	.	ID=gene-Rv1107c;Name=xseB;gbkey=Gene;gene=xseB;gene_biotype=protein_coding;locus_tag=Rv1107c
AL123456.3	EMBL	CDS	1233966	1234223	.	-	0	ID=cds-CCP43860.1;Parent=gene-Rv1107c;Dbxref=EnsemblGenomes-Gn:Rv1107c,EnsemblGenomes-Tr:CCP43860,GOA:P9WF29,InterPro:IPR003761,NCBI_GP:CCP43860.1;Name=CCP43860.1;Note=Rv1107c%2C (MTV017.60c)%2C len: 85 aa. Probable xseB%2Cexonuclease VII small subunit (see citation below). Equivalent to AL049491|MLCB1222_6 Mycobacterium leprae (87 aa) (77.9%25 identity in 68 aa overlap). Similar to P43914|EX7S_HAEIN exodeoxyribonuclease small subunit from H. influenzae (84 aa)%2C FASTA scores: opt: 126%2C E(): 0.006%2C(37.3%25 identity in 67 aa overlap)%3B and P22938|EX7S_ECOLI exodeoxyribonuclease small subunit from Escherichia coli (79 aa)%2C FASTA scores: opt: 125%2C E(): 0.0067%2C (39.7%25 identity in 58 aa overlap). Belongs to the XseB family.;gbkey=CDS;gene=xseB;locus_tag=Rv1107c;product=Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit);protein_id=CCP43860.1;transl_table=11
AL123456.3	EMBL	gene	1234213	1235460	.	-	.	ID=gene-Rv1108c;Name=xseA;gbkey=Gene;gene=xseA;gene_biotype=protein_coding;locus_tag=Rv1108c
AL123456.3	EMBL	CDS	1234213	1235460	.	-	0	ID=cds-CCP43861.1;Parent=gene-Rv1108c;Dbxref=EnsemblGenomes-Gn:Rv1108c,EnsemblGenomes-Tr:CCP43861,GOA:P9WF31,InterPro:IPR003753,InterPro:IPR020579,InterPro:IPR025824,NCBI_GP:CCP43861.1;Name=CCP43861.1;Note=Rv1108c%2C (MTV017.61c)%2C len: 415 aa. Probable xseA%2Cexodeoxyribonuclease VII large subunit (see Mizrahi %26 Andersen 1998). Equivalent to AL049491|MLCB1222_5 Mycobacterium leprae (428 aa) (81.5%25 identity in 411 aa overlap). Similar to many e.g. P04994|EX7L_ECOLI exodeoxyribonuclease large subunit from Escherichia coli (456 aa)%2C FASTA scores: opt: 581%2C E(): 1.6 e-30%2C (30.8%25 identity in 425 aa overlap)%3B also similar to the exodeoxyribonuclease in Bacillus subtilis%2C H. influenzae and H. pylori. Belongs to the XseA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=xseA;locus_tag=Rv1108c;product=Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit);protein_id=CCP43861.1;transl_table=11
AL123456.3	EMBL	gene	1235457	1236095	.	-	.	ID=gene-Rv1109c;Name=Rv1109c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1109c
AL123456.3	EMBL	CDS	1235457	1236095	.	-	0	ID=cds-CCP43862.1;Parent=gene-Rv1109c;Dbxref=EnsemblGenomes-Gn:Rv1109c,EnsemblGenomes-Tr:CCP43862,GOA:P9WM59,NCBI_GP:CCP43862.1;Name=CCP43862.1;Note=Rv1109c%2C (MTV017.62c)%2C len: 212 aa. Conserved protein. Equivalent to AL049491|MLCB1222_4 hypothetical protein from Mycobacterium leprae (205 aa) (68.1%25 identity in 213 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1109c;product=Conserved protein;protein_id=CCP43862.1;transl_table=11
AL123456.3	EMBL	gene	1236185	1237192	.	+	.	ID=gene-Rv1110;Name=lytB2;gbkey=Gene;gene=lytB2;gene_biotype=protein_coding;locus_tag=Rv1110
AL123456.3	EMBL	CDS	1236185	1237192	.	+	0	ID=cds-CCP43863.1;Parent=gene-Rv1110;Dbxref=EnsemblGenomes-Gn:Rv1110,EnsemblGenomes-Tr:CCP43863,GOA:P9WKG1,InterPro:IPR003451,NCBI_GP:CCP43863.1;Name=CCP43863.1;Note=Rv1110%2C (MTV017.63)%2C len: 335 aa. Probable lytB2%2CLytB-related protein%2C equivalent to AL049491|MLCB1222_3 from Mycobacterium leprae (335 aa)%2C FASTA score: (82.9%25 identity in 333 aa overlap). Also similar to LytB proteins from many bacteria (appears to have N-terminal extension) e.g. P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB protein from Escherichia coli strains K12 and O157:H7 (316 aa)%2CFASTA scores: opt: 1041%2C E():0%2C (52.4%25 identity in 309 aa overlap)%3B etc. Also very similar to another LytB-related protein from Mycobacterium tuberculosis: LytB1|Rv3382c|MTV004.40c (329 aa)%2C FASTA scores: opt: 975%2CE(): 0%2C (51.3%25 identity in 312 aa overlap). Belongs to the LytB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lytB2;locus_tag=Rv1110;product=Probable LYTB-related protein LytB2;protein_id=CCP43863.1;transl_table=11
AL123456.3	EMBL	gene	1237209	1238192	.	-	.	ID=gene-Rv1111c;Name=Rv1111c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1111c
AL123456.3	EMBL	CDS	1237209	1238192	.	-	0	ID=cds-CCP43864.1;Parent=gene-Rv1111c;Dbxref=EnsemblGenomes-Gn:Rv1111c,EnsemblGenomes-Tr:CCP43864,UniProtKB/TrEMBL:O86351,NCBI_GP:CCP43864.1;Name=CCP43864.1;Note=Rv1111c%2C (MTV017.64c)%2C len: 327 aa. Conserved hypothetical protein%2C N-terminal domain is hydrophobic%2CC-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0%25 identity in 374 aa overlap). Start changed since first submission. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;gbkey=CDS;locus_tag=Rv1111c;product=Conserved hypothetical protein;protein_id=CCP43864.1;transl_table=11
AL123456.3	EMBL	gene	1238255	1239328	.	+	.	ID=gene-Rv1112;Name=Rv1112;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1112
AL123456.3	EMBL	CDS	1238255	1239328	.	+	0	ID=cds-CCP43865.1;Parent=gene-Rv1112;Dbxref=EnsemblGenomes-Gn:Rv1112,EnsemblGenomes-Tr:CCP43865,GOA:O53459,InterPro:IPR004396,InterPro:IPR006073,InterPro:IPR012675,InterPro:IPR012676,InterPro:IPR013029,InterPro:IPR023192,InterPro:IPR027417,UniProtKB/TrEMBL:O53459,NCBI_GP:CCP43865.1;Name=CCP43865.1;Note=Rv1112%2C (MTCY22G8.01-MTV017.65)%2C len: 357 aa. Probable GTP binding protein%2C similar to YCHF_HAEIN|P44681 probable gtp-binding protein (362 aa)%2C FASTA scores: opt: 1189%2C E(): 0%2C (52.7%25 identity in 357 aa overlap). Equivalent to AL049491|MLCB1222_1 hypothetical protein from Mycobacterium leprae (356 aa) (85.9%25 identity in 354 aa overlap0. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1112;product=Probable GTP binding protein;protein_id=CCP43865.1;transl_table=11
AL123456.3	EMBL	gene	1239416	1239613	.	+	.	ID=gene-Rv1113;Name=vapB32;gbkey=Gene;gene=vapB32;gene_biotype=protein_coding;locus_tag=Rv1113
AL123456.3	EMBL	CDS	1239416	1239613	.	+	0	ID=cds-CCP43866.1;Parent=gene-Rv1113;Dbxref=EnsemblGenomes-Gn:Rv1113,EnsemblGenomes-Tr:CCP43866,GOA:P9WJ33,InterPro:IPR019239,NCBI_GP:CCP43866.1;Name=CCP43866.1;Note=Rv1113%2C (MTCY22G8.02)%2C len: 65 aa. Possible vapB32%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1114%2Csee Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv2758c|AL00896 7|MTV002.23 (88 aa) FASTA scores: opt: 97%2C E(): 0.86%2C (33.3%25 identity in 69 aa overlap). Part of family including Rv2871%2C Rv1241%2C Rv2132%2CRv3321c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB32;locus_tag=Rv1113;product=Possible antitoxin VapB32;protein_id=CCP43866.1;transl_table=11
AL123456.3	EMBL	gene	1239610	1239984	.	+	.	ID=gene-Rv1114;Name=vapC32;gbkey=Gene;gene=vapC32;gene_biotype=protein_coding;locus_tag=Rv1114
AL123456.3	EMBL	CDS	1239610	1239984	.	+	0	ID=cds-CCP43867.1;Parent=gene-Rv1114;Dbxref=EnsemblGenomes-Gn:Rv1114,EnsemblGenomes-Tr:CCP43867,GOA:P9WF73,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43867.1;Name=CCP43867.1;Note=Rv1114%2C (MTCY22G8.03)%2C len: 124 aa. Possible vapC32%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1113%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv1561 and Rv2010.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC32;locus_tag=Rv1114;product=Possible toxin VapC32. Contains PIN domain.;protein_id=CCP43867.1;transl_table=11
AL123456.3	EMBL	gene	1240187	1240885	.	+	.	ID=gene-Rv1115;Name=Rv1115;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1115
AL123456.3	EMBL	CDS	1240187	1240885	.	+	0	ID=cds-CCP43868.1;Parent=gene-Rv1115;Dbxref=EnsemblGenomes-Gn:Rv1115,EnsemblGenomes-Tr:CCP43868,InterPro:IPR000064,UniProtKB/TrEMBL:O06567,NCBI_GP:CCP43868.1;Name=CCP43868.1;Note=Rv1115%2C (MTCY22G8.04)%2C len: 232 aa. Possible exported protein%2C contains possible N-terminal signal sequence.;gbkey=CDS;locus_tag=Rv1115;product=Possible exported protein;protein_id=CCP43868.1;transl_table=11
AL123456.3	EMBL	gene	1241003	1241188	.	+	.	ID=gene-Rv1116;Name=Rv1116;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1116
AL123456.3	EMBL	CDS	1241003	1241188	.	+	0	ID=cds-CCP43869.1;Parent=gene-Rv1116;Dbxref=EnsemblGenomes-Gn:Rv1116,EnsemblGenomes-Tr:CCP43869,UniProtKB/TrEMBL:O06568,NCBI_GP:CCP43869.1;Name=CCP43869.1;Note=Rv1116%2C (MTCY22G8.05)%2C len: 61 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1116;product=Hypothetical protein;protein_id=CCP43869.1;transl_table=11
AL123456.3	EMBL	gene	1241115	1241390	.	-	.	ID=gene-Rv1116A;Name=Rv1116A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1116A
AL123456.3	EMBL	CDS	1241115	1241390	.	-	0	ID=cds-CCP43870.1;Parent=gene-Rv1116A;Dbxref=EnsemblGenomes-Gn:Rv1116A,EnsemblGenomes-Tr:CCP43870,UniProtKB/TrEMBL:L7N6A9,NCBI_GP:CCP43870.1;Name=CCP43870.1;Note=Rv1116A%2C len: 91 aa. Conserved hypothetical protein (possibly gene fragment)%2C similar to C-terminal part of Rv1646|Z85982_9 from Mycobacterium tuberculosis (310 aa)%2CFASTA scores: opt: 301%2C E(): 9.3e-13%2C (68.05%25 identity in 72 aa overlap). Also overlaps gene on other strand%2C Rv1116%2Cat 3'-end.;gbkey=CDS;locus_tag=Rv1116A;product=Conserved hypothetical protein (fragment);protein_id=CCP43870.1;transl_table=11
AL123456.3	EMBL	gene	1241633	1241956	.	+	.	ID=gene-Rv1117;Name=Rv1117;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1117
AL123456.3	EMBL	CDS	1241633	1241956	.	+	0	ID=cds-CCP43871.1;Parent=gene-Rv1117;Dbxref=EnsemblGenomes-Gn:Rv1117,EnsemblGenomes-Tr:CCP43871,InterPro:IPR007138,InterPro:IPR011008,UniProtKB/TrEMBL:O06569,NCBI_GP:CCP43871.1;Name=CCP43871.1;Note=Rv1117%2C (MTCY22G8.06)%2C len: 107 aa. Conserved protein%2C some similarity to P94425|D50453 hypothetical protein from Bacillus subtilis (95 aa)%2C fasta scores: opt: 128%2C E(): 5.1e-06%2C (28.3%25 identity in 92 aa overlap)%3B and AL117322|SCF1.02 Streptomyces coelicolor (109 aa)%2C FASTA scores: opt: 437%2C E(): 1.6e-25%2C (57.5%25 identity in 106 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1117;product=Conserved protein;protein_id=CCP43871.1;transl_table=11
AL123456.3	EMBL	gene	1241971	1242831	.	-	.	ID=gene-Rv1118c;Name=Rv1118c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1118c
AL123456.3	EMBL	CDS	1241971	1242831	.	-	0	ID=cds-CCP43872.1;Parent=gene-Rv1118c;Dbxref=EnsemblGenomes-Gn:Rv1118c,EnsemblGenomes-Tr:CCP43872,GOA:O06570,UniProtKB/TrEMBL:O06570,NCBI_GP:CCP43872.1;Name=CCP43872.1;Note=Rv1118c%2C (MTCY22G8.07c)%2C len: 286 aa. Conserved protein%2C similar to pseudogene ML0942 in Mycobacterium leprae.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1118c;product=Conserved protein;protein_id=CCP43872.1;transl_table=11
AL123456.3	EMBL	gene	1242864	1243013	.	-	.	ID=gene-Rv1119c;Name=Rv1119c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1119c
AL123456.3	EMBL	CDS	1242864	1243013	.	-	0	ID=cds-CCP43873.1;Parent=gene-Rv1119c;Dbxref=EnsemblGenomes-Gn:Rv1119c,EnsemblGenomes-Tr:CCP43873,UniProtKB/TrEMBL:O06571,NCBI_GP:CCP43873.1;Name=CCP43873.1;Note=Rv1119c%2C (MTCY22G8.08c)%2C len: 49 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1119c;product=Hypothetical protein;protein_id=CCP43873.1;transl_table=11
AL123456.3	EMBL	gene	1243010	1243504	.	-	.	ID=gene-Rv1120c;Name=Rv1120c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1120c
AL123456.3	EMBL	CDS	1243010	1243504	.	-	0	ID=cds-CCP43874.1;Parent=gene-Rv1120c;Dbxref=EnsemblGenomes-Gn:Rv1120c,EnsemblGenomes-Tr:CCP43874,GOA:O06572,InterPro:IPR001054,InterPro:IPR029787,UniProtKB/TrEMBL:O06572,NCBI_GP:CCP43874.1;Name=CCP43874.1;Note=Rv1120c%2C (MTCY22G8.09c)%2C len: 164 aa. Conserved hypothetical protein%2C some similarity at C-terminus to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1890c|MTCY180.28 (462 aa)%2C FASTA scores: opt: 187%2C E(): 2.2e-05%2C (36.6%25 identity in 93 aa overlap) and Rv2488c|YZ19_MYCTU|Q10551 (285 aa)%2C FASTA scores: opt: 156%2CE(): 0.00074%2C (32.7%25 identity in 107 aa overlap).;gbkey=CDS;locus_tag=Rv1120c;product=Conserved hypothetical protein;protein_id=CCP43874.1;transl_table=11
AL123456.3	EMBL	gene	1243707	1245107	.	+	.	ID=gene-Rv1121;Name=zwf1;gbkey=Gene;gene=zwf1;gene_biotype=protein_coding;gene_synonym=zwf;locus_tag=Rv1121
AL123456.3	EMBL	CDS	1243707	1245107	.	+	0	ID=cds-CCP43875.1;Parent=gene-Rv1121;Dbxref=EnsemblGenomes-Gn:Rv1121,EnsemblGenomes-Tr:CCP43875,GOA:P9WN71,InterPro:IPR001282,InterPro:IPR016040,InterPro:IPR019796,InterPro:IPR022674,InterPro:IPR022675,NCBI_GP:CCP43875.1;Name=CCP43875.1;Note=Rv1121%2C (MTCY22G8.10)%2C len: 466 aa. Probable zwf1%2Cglucose-6-phosphate 1-dehydrogenase%2C highly similar to many e.g. G6PD_E COLI|P22992 Escherichia coli (491 aa)%2C FASTA scores: opt: 642%2C E(): 0%2C (35.8%25 identity in 478 aa overlap). Mycobacterium tuberculosis has two genes for ZWF%2Cthis one is highly divergent. Belongs to the glucose-6-phosphate dehydrogenase family. Note that previously known as zwf. Nucleotide position 1244700 in the genome sequence has been corrected%2C T:C resulting in L332L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=zwf1;locus_tag=Rv1121;product=Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD);protein_id=CCP43875.1;transl_table=11
AL123456.3	EMBL	gene	1245129	1246151	.	+	.	ID=gene-Rv1122;Name=gnd2;gbkey=Gene;gene=gnd2;gene_biotype=protein_coding;locus_tag=Rv1122
AL123456.3	EMBL	CDS	1245129	1246151	.	+	0	ID=cds-CCP43876.1;Parent=gene-Rv1122;Dbxref=EnsemblGenomes-Gn:Rv1122,EnsemblGenomes-Tr:CCP43876,GOA:O06574,InterPro:IPR004849,InterPro:IPR006114,InterPro:IPR006115,InterPro:IPR008927,InterPro:IPR013328,InterPro:IPR016040,UniProtKB/TrEMBL:O06574,NCBI_GP:CCP43876.1;Name=CCP43876.1;Note=Rv1122%2C (MTCY22G8.11)%2C len: 340 aa. Probable gnd2%2C6-phosphogluconate dehydrogenase%2C decarboxylating%2C highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa)%2C fasta scores: opt: 431%2CE(): 2.2e-20%2C (44.5%25 identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa)%2C FASTA score: (33.0%25 identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms%2C while gnd2 is most similar to gnd's from Gram positive organisms. Belongs to the 6-phosphogluconate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gnd2;locus_tag=Rv1122;product=Probable 6-phosphogluconate dehydrogenase%2Cdecarboxylating Gnd2;protein_id=CCP43876.1;transl_table=11
AL123456.3	EMBL	gene	1246144	1247052	.	-	.	ID=gene-Rv1123c;Name=bpoB;gbkey=Gene;gene=bpoB;gene_biotype=protein_coding;locus_tag=Rv1123c
AL123456.3	EMBL	CDS	1246144	1247052	.	-	0	ID=cds-CCP43877.1;Parent=gene-Rv1123c;Dbxref=EnsemblGenomes-Gn:Rv1123c,EnsemblGenomes-Tr:CCP43877,GOA:O06575,InterPro:IPR029058,UniProtKB/TrEMBL:O06575,NCBI_GP:CCP43877.1;Name=CCP43877.1;Note=Rv1123c%2C (MTCY22G8.12c)%2C len: 302 aa. Possible bpoB%2Cperoxidase (non-haem peroxidase)%2C with some similarity to a range of enzymes from several organisms including: DEH1_MORSP|Q01398 haloacetate dehalogenase from Moraxella sp. (294 aa)%2C FASTA scores: opt: 201%2C E(): 2.1e-06%2C (35.8%25 identity in 134 aa overlap)%3B and BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from Streptomyces aureofaciens (274 aa)%2C FASTA scores: opt: 187%2C E(): 1.6e-05%2C (23.1%25 identity in 281 aa overlap). Similar to several other Mycobacterium tuberculosis proteins%2C probable epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938%2C Rv3617%2C Rv3473c%2CRv3171c%2C etc. Contains PS00216 Sugar transport proteins signature 1.;gbkey=CDS;gene=bpoB;inference=protein motif:PROSITE:PS00216;locus_tag=Rv1123c;product=Possible peroxidase BpoB (non-haem peroxidase);protein_id=CCP43877.1;transl_table=11
AL123456.3	EMBL	gene	1247127	1248077	.	+	.	ID=gene-Rv1124;Name=ephC;gbkey=Gene;gene=ephC;gene_biotype=protein_coding;locus_tag=Rv1124
AL123456.3	EMBL	CDS	1247127	1248077	.	+	0	ID=cds-CCP43878.1;Parent=gene-Rv1124;Dbxref=EnsemblGenomes-Gn:Rv1124,EnsemblGenomes-Tr:CCP43878,GOA:O06576,InterPro:IPR000639,InterPro:IPR029058,UniProtKB/TrEMBL:O06576,NCBI_GP:CCP43878.1;Name=CCP43878.1;Note=Rv1124%2C (MTCY22G8.13)%2C len: 316 aa. Probable ephC%2Cepoxide hydrolase (see citation below)%2C similar to Q42566 epoxide hydrolase from Arabidopsis thaliana (321 aa)%2C FASTA scores: opt: 298%2C E(): 8.2e-13%2C (27.6%25 identity in 333 aa overlap). Similar to other M. tuberculosis epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938%2CRv3617%2C Rv3670%2C Rv3473c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ephC;locus_tag=Rv1124;product=Probable epoxide hydrolase EphC (epoxide hydratase);protein_id=CCP43878.1;transl_table=11
AL123456.3	EMBL	gene	1248082	1249326	.	+	.	ID=gene-Rv1125;Name=Rv1125;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1125
AL123456.3	EMBL	CDS	1248082	1249326	.	+	0	ID=cds-CCP43879.1;Parent=gene-Rv1125;Dbxref=EnsemblGenomes-Gn:Rv1125,EnsemblGenomes-Tr:CCP43879,GOA:O06577,UniProtKB/TrEMBL:O06577,NCBI_GP:CCP43879.1;Name=CCP43879.1;Note=Rv1125%2C (MTCY22G8.14)%2C len: 414 aa. Conserved hypothetical protein. Similar to AL133278|SCM11.13 hypothetical protein from Streptomyces coelicolor (446 aa)%2CFASTA scores: opt: 182%2C E(): 0.0005%2C (28.1%25 identity in 437 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1125;product=Conserved hypothetical protein;protein_id=CCP43879.1;transl_table=11
AL123456.3	EMBL	gene	1249330	1249935	.	-	.	ID=gene-Rv1126c;Name=Rv1126c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1126c
AL123456.3	EMBL	CDS	1249330	1249935	.	-	0	ID=cds-CCP43880.1;Parent=gene-Rv1126c;Dbxref=EnsemblGenomes-Gn:Rv1126c,EnsemblGenomes-Tr:CCP43880,GOA:O06578,UniProtKB/TrEMBL:O06578,NCBI_GP:CCP43880.1;Name=CCP43880.1;Note=Rv1126c%2C (MTCY22G8.15c)%2C len: 201 aa. Conserved protein%2C similar in N-terminus to O05567|MLCB33.17 hypothetical protein from Mycobacterium leprae (141 aa)%2CFASTA scores: opt: 332%2C E(): 1.4e-23%2C (58.4%25 identity in 101 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1126c;product=Conserved protein;protein_id=CCP43880.1;transl_table=11
AL123456.3	EMBL	gene	1249932	1251404	.	-	.	ID=gene-Rv1127c;Name=ppdK;gbkey=Gene;gene=ppdK;gene_biotype=protein_coding;locus_tag=Rv1127c
AL123456.3	EMBL	CDS	1249932	1251404	.	-	0	ID=cds-CCP43881.1;Parent=gene-Rv1127c;Dbxref=EnsemblGenomes-Gn:Rv1127c,EnsemblGenomes-Tr:CCP43881,GOA:O06579,InterPro:IPR002192,InterPro:IPR008279,InterPro:IPR010121,InterPro:IPR013815,InterPro:IPR013816,UniProtKB/TrEMBL:O06579,NCBI_GP:CCP43881.1;Name=CCP43881.1;Note=Rv1127c%2C (MTCY22G8.16c)%2C len: 490 aa. Probable ppdK%2CPyruvate%2C phosphate dikinase. Equivalent (but shorter) to Z94723|MLCB33_16 ppdK from Mycobacterium leprae (601 aa) (71.8%25 identity in 478 aa overlap). Highly similar to N-terminus of PODK_CLOSY|P22983 pyruvate%2C phosphate dikinase from Clostridium symbiosum (873 aa)%2C FASTA scores: opt: 786%2C E(): 0%2C (37.4%25 identity in 514 aa overlap).;gbkey=CDS;gene=ppdK;locus_tag=Rv1127c;product=Probable pyruvate%2C phosphate dikinase PpdK;protein_id=CCP43881.1;transl_table=11
AL123456.3	EMBL	gene	1251617	1252972	.	-	.	ID=gene-Rv1128c;Name=Rv1128c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1128c
AL123456.3	EMBL	CDS	1251617	1252972	.	-	0	ID=cds-CCP43882.1;Parent=gene-Rv1128c;Dbxref=EnsemblGenomes-Gn:Rv1128c,EnsemblGenomes-Tr:CCP43882,GOA:P9WM57,InterPro:IPR003615,InterPro:IPR003870,NCBI_GP:CCP43882.1;Name=CCP43882.1;Note=Rv1128c%2C (MTCY22G8.17c)%2C len: 451 aa. Conserved hypothetical protein%2C in REP13E12 degenerate repeat%2C highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c%2C Rv1945%2C Rv3467%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1128c;product=Conserved hypothetical protein;protein_id=CCP43882.1;transl_table=11
AL123456.3	EMBL	repeat_region	1251621	1252945	.	+	.	ID=id-AL123456.3:1251621..1252945;Note=REP-3%2C len: 1325 nt. REP22G8%2C member of REP13E12 family.;gbkey=repeat_region
AL123456.3	EMBL	gene	1253074	1254534	.	-	.	ID=gene-Rv1129c;Name=Rv1129c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1129c
AL123456.3	EMBL	CDS	1253074	1254534	.	-	0	ID=cds-CCP43883.1;Parent=gene-Rv1129c;Dbxref=EnsemblGenomes-Gn:Rv1129c,EnsemblGenomes-Tr:CCP43883,GOA:O06581,InterPro:IPR001387,InterPro:IPR010359,InterPro:IPR010982,InterPro:IPR018653,InterPro:IPR026281,UniProtKB/TrEMBL:O06581,NCBI_GP:CCP43883.1;Name=CCP43883.1;Note=Rv1129c%2C (MTCY22G8.18c)%2C len: 486 aa. Possible transcriptional regulator protein%2C similar to Rv0465c|MTV038.09c Mycobacterium tuberculosis (474 aa)%2CFASTA scores: E(): 0%2C (47.4%25 identity in 468 aa overlap). Helix turn helix motif present from aa 32-53.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1129c;product=Probable transcriptional regulator protein;protein_id=CCP43883.1;transl_table=11
AL123456.3	EMBL	gene	1254555	1256135	.	+	.	ID=gene-Rv1130;Name=prpD;gbkey=Gene;gene=prpD;gene_biotype=protein_coding;locus_tag=Rv1130
AL123456.3	EMBL	CDS	1254555	1256135	.	+	0	ID=cds-CCP43884.1;Parent=gene-Rv1130;Dbxref=EnsemblGenomes-Gn:Rv1130,EnsemblGenomes-Tr:CCP43884,GOA:O06582,InterPro:IPR005656,UniProtKB/TrEMBL:O06582,NCBI_GP:CCP43884.1;Name=CCP43884.1;Note=Rv1130%2C (MTCY22G8.19)%2C len: 526 aa. Possible prpD%2Cmethylcitrate dehydratase (MCD)%2C some similarity to AP000063|AP000063_192 hypothetical protein from Aeropyrum pernix (479 aa)%2C FASTA scores: opt: 717%2C E(): 0%2C (34.3%25 identity in 443 a a overlap)%2C and to PRPD_ECOLI|P77243 prpd protein from Escherichia coli (483aa)%2C FASTA scores: opt: 234%2C E(): 3.3e-08%2C (27.0%25 identity in 429 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prpD;locus_tag=Rv1130;product=Possible methylcitrate dehydratase PrpD;protein_id=CCP43884.1;transl_table=11
AL123456.3	EMBL	gene	1256132	1257313	.	+	.	ID=gene-Rv1131;Name=prpC;gbkey=Gene;gene=prpC;gene_biotype=protein_coding;gene_synonym=gltA1;locus_tag=Rv1131
AL123456.3	EMBL	CDS	1256132	1257313	.	+	0	ID=cds-CCP43885.1;Parent=gene-Rv1131;Dbxref=EnsemblGenomes-Gn:Rv1131,EnsemblGenomes-Tr:CCP43885,GOA:I6Y9Q3,InterPro:IPR002020,InterPro:IPR011278,InterPro:IPR016141,InterPro:IPR016142,InterPro:IPR016143,InterPro:IPR019810,InterPro:IPR024176,UniProtKB/TrEMBL:I6Y9Q3,NCBI_GP:CCP43885.1;Name=CCP43885.1;Note=Rv1131%2C (MTCY22G8.20)%2C len: 393 aa. Probable prpC%2Cmethylcitrate synthase (MCS) (previously known as gltA1) %2Chighly similar to CISY_MYCSM|P26491 citrate synthase from Mycobacterium smegmatis (375 aa)%2C FASTA scores: opt:1942%2CE(): 0%2C (80.0%25 identity in 375 aa overlap). Also similar to two other M. tuberculosis citrate synthases%2CRv0896c|MTCY31.24|gltA2 (431 aa)%2C FASTA score: (33.1%25 identity in 381 aa overlap) and Rv0889|MTCY31.17c|citA (373 aa)%2C FASTA score: (31.8%25 identity in 371 aa overlap). Contains PS00480 Citrate synthase signature. Belongs to the citrate synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prpC;inference=protein motif:PROSITE:PS00480;locus_tag=Rv1131;product=Probable methylcitrate synthase PrpC;protein_id=CCP43885.1;transl_table=11
AL123456.3	EMBL	gene	1257325	1259055	.	+	.	ID=gene-Rv1132;Name=Rv1132;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1132
AL123456.3	EMBL	CDS	1257325	1259055	.	+	0	ID=cds-CCP43886.1;Parent=gene-Rv1132;Dbxref=EnsemblGenomes-Gn:Rv1132,EnsemblGenomes-Tr:CCP43886,GOA:O06583,InterPro:IPR021941,UniProtKB/TrEMBL:O06583,NCBI_GP:CCP43886.1;Name=CCP43886.1;Note=Rv1132%2C (MTCY22G8.21)%2C len: 576 aa. Conserved membrane protein%2C similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa)%2Cfasta scores: opt: 1811%2C E(): 0%2C (48.2%25 identity in 585 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1132;product=Conserved membrane protein;protein_id=CCP43886.1;transl_table=11
AL123456.3	EMBL	gene	1259067	1261346	.	-	.	ID=gene-Rv1133c;Name=metE;gbkey=Gene;gene=metE;gene_biotype=protein_coding;locus_tag=Rv1133c
AL123456.3	EMBL	CDS	1259067	1261346	.	-	0	ID=cds-CCP43887.1;Parent=gene-Rv1133c;Dbxref=EnsemblGenomes-Gn:Rv1133c,EnsemblGenomes-Tr:CCP43887,GOA:P9WK07,InterPro:IPR002629,InterPro:IPR006276,InterPro:IPR013215,NCBI_GP:CCP43887.1;Name=CCP43887.1;Note=Rv1133c%2C (MTC22G8.22)%2C len: 759 aa (start site chosen by homology). Probable metE%2C5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase%2C highly similar to others e.g. METE_ECOLI|P25665 Escherichia coli (752 aa)%2C FASTA scores: opt: 2251%2C E(): 0%2C (48.1%25 identity in 756 aa overlap). Equivalent to Z94723|MLCB33_14 metE from M. leprae (760 aa) (85.3%25 identity in 755 aa overlap). Belongs to the vitamin-B12 independent methionine synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metE;locus_tag=Rv1133c;product=Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase%2C vitamin-B12 independent isozyme);protein_id=CCP43887.1;transl_table=11
AL123456.3	EMBL	gene	1261922	1262158	.	+	.	ID=gene-Rv1134;Name=Rv1134;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1134
AL123456.3	EMBL	CDS	1261922	1262158	.	+	0	ID=cds-CCP43888.1;Parent=gene-Rv1134;Dbxref=EnsemblGenomes-Gn:Rv1134,EnsemblGenomes-Tr:CCP43888,UniProtKB/TrEMBL:O06534,NCBI_GP:CCP43888.1;Name=CCP43888.1;Note=Rv1134%2C (MTCI65.01)%2C len: 78 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1134;product=Hypothetical protein;protein_id=CCP43888.1;transl_table=11
AL123456.3	EMBL	gene	1262272	1264128	.	-	.	ID=gene-Rv1135c;Name=PPE16;gbkey=Gene;gene=PPE16;gene_biotype=protein_coding;locus_tag=Rv1135c
AL123456.3	EMBL	CDS	1262272	1264128	.	-	0	ID=cds-CCP43889.1;Parent=gene-Rv1135c;Dbxref=EnsemblGenomes-Gn:Rv1135c,EnsemblGenomes-Tr:CCP43889,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP43889.1;Name=CCP43889.1;Note=Rv1135c%2C (MTCI65.02c)%2C len: 618 aa. PPE16%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to Rv2356c (59.6%25 identity in 627 aa overlap)%3B etc.. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=PPE16;locus_tag=Rv1135c;product=PPE family protein PPE16;protein_id=CCP43889.1;transl_table=11
AL123456.3	EMBL	gene	1264314	1264556	.	+	.	ID=gene-Rv1135A;Name=Rv1135A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1135A
AL123456.3	EMBL	CDS	1264314	1264556	.	+	0	ID=cds-CCP43890.1;Parent=gene-Rv1135A;Dbxref=EnsemblGenomes-Gn:Rv1135A,EnsemblGenomes-Tr:CCP43890,GOA:L7N682,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020617,UniProtKB/TrEMBL:L7N682,NCBI_GP:CCP43890.1;Name=CCP43890.1;Note=Rv1135A%2C len: 80 aa. Possible acetyl-CoA acetyltransferase (possible gene fragment)%2C highly similar to other acetyl-CoA acetyltransferases e.g. C-terminal part of Rv3556c|Z92774|MTCY6G11_2|MTCY06G11.03|fadA6 acetyl-CoA acetyltransferase from Mycobacterium tuberculosis (386 aa)%2CFASTA scores: opt: 219%2C E(): 5.7e-09%2C (63.6%25 identity in 55 aa overlap).;gbkey=CDS;locus_tag=Rv1135A;product=Possible acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase);protein_id=CCP43890.1;transl_table=11
AL123456.3	EMBL	gene	1264606	1264947	.	+	.	ID=gene-Rv1136;Name=Rv1136;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1136
AL123456.3	EMBL	CDS	1264606	1264947	.	+	0	ID=cds-CCP43891.1;Parent=gene-Rv1136;Dbxref=EnsemblGenomes-Gn:Rv1136,EnsemblGenomes-Tr:CCP43891,GOA:O06536,InterPro:IPR001753,InterPro:IPR029045,UniProtKB/TrEMBL:O06536,NCBI_GP:CCP43891.1;Name=CCP43891.1;Note=Rv1136%2C (MTCI65.03)%2C len: 113 aa. Probable enoyl-CoA hydratase (possible gene fragment). Some similarity to N-terminus of carnitine racemases and enoyl-CoA hydratases (but much shorter) e.g. I41014 carnitine racemase from Escherichia coli (297 aa)%2C FASTA scores: opt: 258%2C E(): 2.5e-11%2C (44.5%25 identity in 110 aa overlap)%3B and Rv0222 putative enoyl-CoA hydratase from M. tuberculosis (262 aa).;gbkey=CDS;locus_tag=Rv1136;product=Possible enoyl-CoA hydratase;protein_id=CCP43891.1;transl_table=11
AL123456.3	EMBL	gene	1265087	1265455	.	-	.	ID=gene-Rv1137c;Name=Rv1137c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1137c
AL123456.3	EMBL	CDS	1265087	1265455	.	-	0	ID=cds-CCP43892.1;Parent=gene-Rv1137c;Dbxref=EnsemblGenomes-Gn:Rv1137c,EnsemblGenomes-Tr:CCP43892,UniProtKB/TrEMBL:O06537,NCBI_GP:CCP43892.1;Name=CCP43892.1;Note=Rv1137c%2C (MTCI65.04c)%2C len: 122 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1137c;product=Hypothetical protein;protein_id=CCP43892.1;transl_table=11
AL123456.3	EMBL	gene	1265472	1266488	.	-	.	ID=gene-Rv1138c;Name=Rv1138c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1138c
AL123456.3	EMBL	CDS	1265472	1266488	.	-	0	ID=cds-CCP43893.1;Parent=gene-Rv1138c;Dbxref=EnsemblGenomes-Gn:Rv1138c,EnsemblGenomes-Tr:CCP43893,GOA:O06538,InterPro:IPR002938,InterPro:IPR003042,UniProtKB/TrEMBL:O06538,NCBI_GP:CCP43893.1;Name=CCP43893.1;Note=Rv1138c%2C (MTCI65.05c)%2C len: 338 aa. Possible oxidoreductase%2C similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypothetical proteins e.g. Rv1751|P72008|MTCY04C12.35 (412 aa)%2C fasta scores: opt: 89%2CE(): 4.5e-09%2C (24.6%25 identity in 358 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1138c;product=Possible oxidoreductase;protein_id=CCP43893.1;transl_table=11
AL123456.3	EMBL	gene	1266485	1266985	.	-	.	ID=gene-Rv1139c;Name=Rv1139c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1139c
AL123456.3	EMBL	CDS	1266485	1266985	.	-	0	ID=cds-CCP43894.1;Parent=gene-Rv1139c;Dbxref=EnsemblGenomes-Gn:Rv1139c,EnsemblGenomes-Tr:CCP43894,GOA:O06539,InterPro:IPR007269,UniProtKB/TrEMBL:O06539,NCBI_GP:CCP43894.1;Name=CCP43894.1;Note=Rv1139c%2C (MTCI65.06c)%2C len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein%2CYBPQ (168 aa)%2C FASTA scores: opt: 446%2C E(): 2.2e-26%2C (38.4%25 identity in 164 aa overlap). Some similarity to Mycobacterium tuberculosis hypothetical proteins%2C Rv0740%2CRv0750.;gbkey=CDS;locus_tag=Rv1139c;product=Conserved hypothetical membrane protein;protein_id=CCP43894.1;transl_table=11
AL123456.3	EMBL	gene	1267347	1268195	.	+	.	ID=gene-Rv1140;Name=Rv1140;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1140
AL123456.3	EMBL	CDS	1267347	1268195	.	+	0	ID=cds-CCP43895.1;Parent=gene-Rv1140;Dbxref=EnsemblGenomes-Gn:Rv1140,EnsemblGenomes-Tr:CCP43895,GOA:O06540,InterPro:IPR003675,UniProtKB/TrEMBL:O06540,NCBI_GP:CCP43895.1;Name=CCP43895.1;Note=Rv1140%2C (MTCI65.07)%2C len: 282 aa. Probable integral membrane protein. Weak similarity in C-terminus to hypothetical Escherichia coli proteins YPRA and YPRB%2Cpossibly membrane-bound e.g. YPRA_ECOLI hypothetical 24.3 kDa protein (URF 1) (217 aa)%2C FASTA scores: opt: 166%2C E(): 0.00062%2C (31.0%25 identity in 158 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1140;product=Probable integral membrane protein;protein_id=CCP43895.1;transl_table=11
AL123456.3	EMBL	gene	1268203	1269009	.	-	.	ID=gene-Rv1141c;Name=echA11;gbkey=Gene;gene=echA11;gene_biotype=protein_coding;locus_tag=Rv1141c
AL123456.3	EMBL	CDS	1268203	1269009	.	-	0	ID=cds-CCP43896.1;Parent=gene-Rv1141c;Dbxref=EnsemblGenomes-Gn:Rv1141c,EnsemblGenomes-Tr:CCP43896,GOA:O06541,InterPro:IPR001753,InterPro:IPR014748,InterPro:IPR029045,UniProtKB/TrEMBL:O06541,NCBI_GP:CCP43896.1;Name=CCP43896.1;Note=Rv1141c%2C (MTCI65.08c)%2C len: 268 aa. Probable echA11%2Cenoyl-CoA hydratase%2C similar to others e.g. P24162|ECHH_RHOCA probable enoyl-CoA hydratase from Rhodobacter capsulatus(257 aa)%3B CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa)%2C FASTA scores: opt: 513%2C E():1e-25%2C (36.1%25 identity in 249 aa overlap)%3B etc. Also similarity with naphthoate synthases. Also highly similar to downstream ORF Rv1142c|MTCI65.09|echA10 probable enoyl-CoA hydratase from Mycobacterium tuberculosis (268 aa)%2C FASTA scores: opt: 1225%2C E(): 0%2C (72.3%25 identity in 267 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA11;locus_tag=Rv1141c;product=Probable enoyl-CoA hydratase EchA11 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43896.1;transl_table=11
AL123456.3	EMBL	gene	1269152	1269958	.	-	.	ID=gene-Rv1142c;Name=echA10;gbkey=Gene;gene=echA10;gene_biotype=protein_coding;locus_tag=Rv1142c
AL123456.3	EMBL	CDS	1269152	1269958	.	-	0	ID=cds-CCP43897.1;Parent=gene-Rv1142c;Dbxref=EnsemblGenomes-Gn:Rv1142c,EnsemblGenomes-Tr:CCP43897,GOA:O06542,InterPro:IPR001753,InterPro:IPR014748,InterPro:IPR029045,UniProtKB/TrEMBL:O06542,NCBI_GP:CCP43897.1;Name=CCP43897.1;Note=Rv1142c%2C (MTCI65.09c)%2C len: 268 aa. Probable echA10%2Cenoyl-CoA hydratase%2C similar to others e.g. CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli (262 aa)%2C FASTA scores: opt: 525%2C E(): 1.3e-26%2C (35.1%25 identity in 251 aa overlap)%3B NP_420658.1|NC_002696 enoyl-CoA hydratase/isomerase family protein from Caulobacter crescentus (267 aa)%3B NP_438092.1|NC_003078 putative enoyl-CoA hydratase protein from Sinorhizobium meliloti (263 aa)%3B etc. Also similarity with naphthoate synthases. Also highly similar to upstream ORF Rv1141c|MTCI65.08c|echA11 probable enoyl-CoA hydratase from Mycobacterium tuberculosis (268 aa)%2C FASTA score: opt: 1225%2C E(): 0%2C (72.3%25 identity in 267 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA10;locus_tag=Rv1142c;product=Probable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP43897.1;transl_table=11
AL123456.3	EMBL	gene	1270062	1271144	.	+	.	ID=gene-Rv1143;Name=mcr;gbkey=Gene;gene=mcr;gene_biotype=protein_coding;locus_tag=Rv1143
AL123456.3	EMBL	CDS	1270062	1271144	.	+	0	ID=cds-CCP43898.1;Parent=gene-Rv1143;Dbxref=EnsemblGenomes-Gn:Rv1143,EnsemblGenomes-Tr:CCP43898,GOA:O06543,InterPro:IPR003673,InterPro:IPR023606,PDB:1X74,PDB:2GCE,PDB:2GCI,PDB:2GD0,PDB:2GD2,PDB:2GD6,PDB:2YIM,UniProtKB/TrEMBL:O06543,NCBI_GP:CCP43898.1;Name=CCP43898.1;Note=Rv1143%2C (MTCI65.10)%2C len: 360 aa. Probable mcr%2Calpha-methylacyl-CoA racemase. Strong similarity to other alpha-methylacyl-CoA racemases and also some similarity to L-carnitine dehydratase e.g. U89905|g1552373 methylacyl-CoA racemase alpha from Norway rat (361 aa)%2C FASTA scores: opt: 1035%2C E():0%2C (47.2%25 identity in 339 aa overlap). Equivalent to (but longer than) Z94723|MLCB33_13 Mycobacterium leprae (253 aa) (85.3%25 identity in 245 aa overlap). Also similar to Mycobacterium tuberculosis putative racemases Rv0855%2CRv1866%2C Rv3272.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mcr;locus_tag=Rv1143;product=Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase);protein_id=CCP43898.1;transl_table=11
AL123456.3	EMBL	gene	1271156	1271908	.	+	.	ID=gene-Rv1144;Name=Rv1144;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1144
AL123456.3	EMBL	CDS	1271156	1271908	.	+	0	ID=cds-CCP43899.1;Parent=gene-Rv1144;Dbxref=EnsemblGenomes-Gn:Rv1144,EnsemblGenomes-Tr:CCP43899,GOA:P9WGQ7,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP43899.1;Name=CCP43899.1;Note=Rv1144%2C (MTCI65.11)%2C len: 250 aa. Probable short-chain dehydrogenase/reductase%2C highly similar to various dehydrogenases e.g. NP_104056.1|NC_002678 3-hydroxyacyl-CoA dehydrogenase type II from Mesorhizobium loti (253 aa)%3B NP_251244.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (255 aa)%3B AAK15008.1|AF233685_1|AF233685 short chain L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus (261 aa)%3B HSU73514|g1778354|XH98G2 human short-chain alcohol dehydrogenase from Homo sapiens (261 aa)%2C FASTA scores: opt: 875%2C E(): 0%2C (60.1%25 identity in 253 aa overlap)%3B etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1144;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP43899.1;transl_table=11
AL123456.3	EMBL	gene	1272423	1273334	.	+	.	ID=gene-Rv1145;Name=mmpL13a;gbkey=Gene;gene=mmpL13a;gene_biotype=protein_coding;locus_tag=Rv1145
AL123456.3	EMBL	CDS	1272423	1273334	.	+	0	ID=cds-CCP43900.1;Parent=gene-Rv1145;Dbxref=EnsemblGenomes-Gn:Rv1145,EnsemblGenomes-Tr:CCP43900,GOA:O06545,InterPro:IPR004869,UniProtKB/TrEMBL:O06545,NCBI_GP:CCP43900.1;Name=CCP43900.1;Note=Rv1145%2C (MTCI65.12)%2C len: 303 aa. Probable mmpL13a%2Cconserved transmembrane transport protein (see citation below)%2C member of RND superfamily%2C showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. MTCY987|g1781238 from Mycobacterium tuberculosis (962 aa)%2C FASTA scores: opt: 213%2C E(): 1.9e-06%2C (28.0%25 identity in 296 aa overlap)%3B etc. Strong similarity to U92075|MMU92075_5 hypothetical protein from Mycobacterium marinum (256 aa)%2C FASTA scores: opt: 957%2CE(): 0%2C (57.6%25 identity in 257 aa overlap). Should continue as mmpL13B|Rv1146%2C but frameshift required. Sequence has been checked and is identical in M. tuberculosis strain CDC1551%2C and Mycobacterium bovis strain AF2122/97. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL13a;locus_tag=Rv1145;product=Probable conserved transmembrane transport protein MmpL13a;protein_id=CCP43900.1;transl_table=11
AL123456.3	EMBL	gene	1273355	1274767	.	+	.	ID=gene-Rv1146;Name=mmpL13b;gbkey=Gene;gene=mmpL13b;gene_biotype=protein_coding;locus_tag=Rv1146
AL123456.3	EMBL	CDS	1273355	1274767	.	+	0	ID=cds-CCP43901.1;Parent=gene-Rv1146;Dbxref=EnsemblGenomes-Gn:Rv1146,EnsemblGenomes-Tr:CCP43901,GOA:O06546,InterPro:IPR004869,UniProtKB/TrEMBL:O06546,NCBI_GP:CCP43901.1;Name=CCP43901.1;Note=Rv1146%2C (MTCI65.13)%2C len: 470 aa. Probable mmpL13b%2Cconserved transmembrane transport protein (see citation below)%2C member of RND superfamily%2C showing some similarity to putative Mycobacterial and Streptomyces membrane proteins e.g. Q53902|C40046 antibiotic transport-associated protein from Streptomyces coelicolor (711 aa)%2C FASTA scores: opt: 193%2C E(): 2.1e-05%2C (28.9%25 identity in 394 aa overlap)%3B etc. Could be in frame with previous ORF mmpL13A|Rv1145%2C but no sequence error apparent to account for this%3B sequence is identical in M. tuberculosis strain CDC1551%2C and Mycobacterium bovis strain AF2122/97. Belongs to the MmpL family.;gbkey=CDS;gene=mmpL13b;locus_tag=Rv1146;product=Probable conserved transmembrane transport protein MmpL13b;protein_id=CCP43901.1;transl_table=11
AL123456.3	EMBL	gene	1274900	1275550	.	+	.	ID=gene-Rv1147;Name=Rv1147;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1147
AL123456.3	EMBL	CDS	1274900	1275550	.	+	0	ID=cds-CCP43902.1;Parent=gene-Rv1147;Dbxref=EnsemblGenomes-Gn:Rv1147,EnsemblGenomes-Tr:CCP43902,InterPro:IPR029063,UniProtKB/TrEMBL:O06547,NCBI_GP:CCP43902.1;Name=CCP43902.1;Note=Rv1147%2C (MTCI65.14)%2C len: 216 aa. Conserved protein%2Csimilar to many conserved hypothetical proteins%2C and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase from R. sphaeroides (203 aa)%2C FASTA scores: opt: 156%2C E(): 0.00073%2C (27.6%25 identity in 156 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1147;product=Conserved protein;protein_id=CCP43902.1;transl_table=11
AL123456.3	EMBL	repeat_region	1276296	1277643	.	+	.	ID=id-AL123456.3:1276296..1277643;Note=REP-4%2C len: 1348 nt. REP165%2C member of REP13E12 family.;gbkey=repeat_region
AL123456.3	EMBL	gene	1276300	1277748	.	-	.	ID=gene-Rv1148c;Name=Rv1148c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1148c
AL123456.3	EMBL	CDS	1276300	1277748	.	-	0	ID=cds-CCP43903.1;Parent=gene-Rv1148c;Dbxref=EnsemblGenomes-Gn:Rv1148c,EnsemblGenomes-Tr:CCP43903,GOA:P9WM55,InterPro:IPR002711,InterPro:IPR003615,InterPro:IPR003870,NCBI_GP:CCP43903.1;Name=CCP43903.1;Note=Rv1148c%2C (MTCI65.15c)%2C len: 482 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat%2C nearly identical to other hypothetical Mycobacterium tuberculosis proteins in REP13E12 repeats%2C although similarity extends upstream past proposed f-Met start. Very similar to other REP13E12 proteins e.g. Rv1945%2C Rv3467%2C Rv0094c%2C Rv1128c etc.;gbkey=CDS;locus_tag=Rv1148c;product=Conserved hypothetical protein;protein_id=CCP43903.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1277843	1278826	.	+	.	ID=id-AL123456.3:1277843..1278826;Note=IS-LIKE-2%2C len: 984 nt. Insertion sequence element IS-LIKE.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS-LIKE-2
AL123456.3	EMBL	repeat_region	1277843	1277846	.	+	.	ID=id-AL123456.3:1277843..1277846;Note=4 bp direct repeat%2C CTAG%2C generated by IS element on insertion. Proposed by Mariani et al. 1993. J. Gen. Microbiol.%2C 139: 1767-1772. Note that as motif palindromic could be part of inverted repeat itself.;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	1277847	1277863	.	+	.	ID=id-AL123456.3:1277847..1277863;Note=17 bp Inverted repeat at the left end of putative IS-LIKE-2 element : GGCGTGTCTCCCAAATT. Proposed by Mariani et al. 1993. J. Gen. Microbiol. 139: 1767-1772.;gbkey=repeat_region
AL123456.3	EMBL	gene	1277893	1278300	.	+	.	ID=gene-Rv1149;Name=Rv1149;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1149
AL123456.3	EMBL	CDS	1277893	1278300	.	+	0	ID=cds-CCP43904.1;Parent=gene-Rv1149;Dbxref=EnsemblGenomes-Gn:Rv1149,EnsemblGenomes-Tr:CCP43904,InterPro:IPR025161,UniProtKB/TrEMBL:L0T897,NCBI_GP:CCP43904.1;Name=CCP43904.1;Note=Rv1149%2C (MTCI65.16)%2C len: 135 aa. Possible transposase. Identical to 117 aa N-terminal region of S21394|X65618 transposase of Mycobacterium tuberculosis (308 aa)%2C FASTA scores: opt: 823%2C E(): 0%2C (99.1%25 identity in 117 aa overlap). Second copy is Rv1042c|MTCY10G2.07.;gbkey=CDS;locus_tag=Rv1149;product=Possible transposase;protein_id=CCP43904.1;transl_table=11
AL123456.3	EMBL	pseudogene	1278269	1278820	.	+	.	ID=gene-Rv1150;Name=Rv1150;gbkey=Gene;gene_biotype=pseudogene;locus_tag=Rv1150;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	1278269	1278820	.	+	0	ID=cds-Rv1150;Parent=gene-Rv1150;Note=Rv1150%2C (MTCI65.17)%2C len: 183 aa. Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of putative Mycobacterium tuberculosis is element (308 aa)%2C FASTA scores: opt: 959%2CE(): 0%2C (99.3%25 identity in 145 aa overlap). The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08.;gbkey=CDS;locus_tag=Rv1150;product=Possible transposase (fragment);pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	repeat_region	1278817	1278820	.	+	.	ID=id-Rv1150;Note=4 bp direct repeat%2C CTAG generated by IS element on insertion. Proposed by Mariani et al. 1993. J. Gen. Microbiol. 139: 1767-1772. Note that as motif palindromic could be part of inverted repeat itself.;gbkey=repeat_region;locus_tag=Rv1150;pseudo=true
AL123456.3	EMBL	repeat_region	1278800	1278816	.	-	.	ID=id-AL123456.3:1278800..1278816;Note=17 bp Inverted repeat at the right end of putative IS-LIKE-2 element :GGCGTGTCTCCCAATTT. Proposed by Mariani et al. 1993. J. Gen. Microbiol. 139: 1767-1772;gbkey=repeat_region
AL123456.3	EMBL	gene	1278904	1279617	.	-	.	ID=gene-Rv1151c;Name=Rv1151c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1151c
AL123456.3	EMBL	CDS	1278904	1279617	.	-	0	ID=cds-CCP43906.1;Parent=gene-Rv1151c;Dbxref=EnsemblGenomes-Gn:Rv1151c,EnsemblGenomes-Tr:CCP43906,GOA:P9WGG3,InterPro:IPR003000,InterPro:IPR026590,InterPro:IPR026591,InterPro:IPR027546,InterPro:IPR029035,NCBI_GP:CCP43906.1;Name=CCP43906.1;Note=Rv1151c%2C (MTCI65.18c)%2C len: 237 aa. Transcriptional regulatory protein%2C similar to others AE000776|AE000776_10 Aquifex aeolicus (239 aa)%2C FASTA scores: opt: 725%2C E(): 0%2C(46.4%25 identity in 237 aa overlap)%3B ECAE0002125|g1787358 Escherichia coli (279 aa)%2C FASTA scores: opt: 464%2C E(): 1.3e-23%2C (36.7%25 identity in 240 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1151c;product=Transcriptional regulatory protein;protein_id=CCP43906.1;transl_table=11
AL123456.3	EMBL	gene	1279655	1280020	.	+	.	ID=gene-Rv1152;Name=Rv1152;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1152
AL123456.3	EMBL	CDS	1279655	1280020	.	+	0	ID=cds-CCP43907.1;Parent=gene-Rv1152;Dbxref=EnsemblGenomes-Gn:Rv1152,EnsemblGenomes-Tr:CCP43907,GOA:O06550,InterPro:IPR000524,InterPro:IPR011991,UniProtKB/TrEMBL:O06550,NCBI_GP:CCP43907.1;Name=CCP43907.1;Note=Rv1152%2C (MTCI65.19)%2C len: 121 aa (Start uncertain). Probable transcriptional regulatory protein%2C some similarity to others e.g. YHCF_BACSU hypothetical transcriptional regulator (121 aa)%2C FASTA scores: opt: 187%2CE(): 1.9e-06%2C (34.9%25 identity in 106 aa overlap). Helix turn helix motif from aa 42-63 (+3.10 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1152;product=Probable transcriptional regulatory protein;protein_id=CCP43907.1;transl_table=11
AL123456.3	EMBL	gene	1279998	1280846	.	-	.	ID=gene-Rv1153c;Name=omt;gbkey=Gene;gene=omt;gene_biotype=protein_coding;locus_tag=Rv1153c
AL123456.3	EMBL	CDS	1279998	1280846	.	-	0	ID=cds-CCP43908.1;Parent=gene-Rv1153c;Dbxref=EnsemblGenomes-Gn:Rv1153c,EnsemblGenomes-Tr:CCP43908,GOA:O06551,InterPro:IPR007213,InterPro:IPR016874,InterPro:IPR029063,UniProtKB/TrEMBL:O06551,NCBI_GP:CCP43908.1;Name=CCP43908.1;Note=Rv1153c%2C (MTCI65.20c)%2C len: 282 aa. Probable omt%2CO-methyltransferase%2C similar to TCMP_STRGA|P39887 Tetracenomycin polyketide synthesis O-methyltransferase tcmP from Streptomyces glaucescens (270 aa)%2C FASTA scores: opt: 368%2C E(): 1.7e-17%2C (31.3%25 identity in 233 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=omt;locus_tag=Rv1153c;product=Probable O-methyltransferase Omt;protein_id=CCP43908.1;transl_table=11
AL123456.3	EMBL	gene	1280843	1281484	.	-	.	ID=gene-Rv1154c;Name=Rv1154c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1154c
AL123456.3	EMBL	CDS	1280843	1281484	.	-	0	ID=cds-CCP43909.1;Parent=gene-Rv1154c;Dbxref=EnsemblGenomes-Gn:Rv1154c,EnsemblGenomes-Tr:CCP43909,InterPro:IPR012545,UniProtKB/TrEMBL:O06552,NCBI_GP:CCP43909.1;Name=CCP43909.1;Note=Rv1154c%2C (MTCI65.21c)%2C len: 213 aa. Hypothetical unknown protein%2C start uncertain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1154c;product=Hypothetical protein;protein_id=CCP43909.1;transl_table=11
AL123456.3	EMBL	gene	1281429	1281872	.	+	.	ID=gene-Rv1155;Name=Rv1155;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1155
AL123456.3	EMBL	CDS	1281429	1281872	.	+	0	ID=cds-CCP43910.1;Parent=gene-Rv1155;Dbxref=EnsemblGenomes-Gn:Rv1155,EnsemblGenomes-Tr:CCP43910,GOA:O06553,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019920,PDB:1W9A,PDB:1XXO,PDB:1Y30,PDB:2AQ6,NCBI_GP:CCP43910.1;Name=CCP43910.1;Note=Rv1155%2C (MTCI65.22)%2C len: 147 aa. Possible pyridoxine 5'-phosphate oxidase (PNPOx) (See Biswal et al.%2C2005%3B Canaan et al.%2C 2005). Similar to hypothetical proteins e.g. AL079356|SC6G9.20 Streptomyces coelicolor (144 aa)%2C FASTA scores: opt: 478%2C E(): 2.8e-26%2C (55.7%25 identity in 140 aa overlap)%3B and Mycobacterium tuberculosis proteins Rv1875%2C Rv0121c%2C Rv2074.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1155;product=Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase);protein_id=CCP43910.1;transl_table=11
AL123456.3	EMBL	gene	1282306	1282893	.	+	.	ID=gene-Rv1156;Name=Rv1156;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1156
AL123456.3	EMBL	CDS	1282306	1282893	.	+	0	ID=cds-CCP43911.1;Parent=gene-Rv1156;Dbxref=EnsemblGenomes-Gn:Rv1156,EnsemblGenomes-Tr:CCP43911,GOA:O06554,InterPro:IPR003265,InterPro:IPR011257,InterPro:IPR017658,UniProtKB/TrEMBL:O06554,NCBI_GP:CCP43911.1;Name=CCP43911.1;Note=Rv1156%2C (MTCI65.23)%2C len: 195 aa. Conserved protein%2Chighly similar to CAC32318.1|AL583944 conserved hypothetical protein from Streptomyces coelicolor (197 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1156;product=Conserved protein;protein_id=CCP43911.1;transl_table=11
AL123456.3	EMBL	gene	1283056	1284171	.	-	.	ID=gene-Rv1157c;Name=Rv1157c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1157c
AL123456.3	EMBL	CDS	1283056	1284171	.	-	0	ID=cds-CCP43912.1;Parent=gene-Rv1157c;Dbxref=EnsemblGenomes-Gn:Rv1157c,EnsemblGenomes-Tr:CCP43912,GOA:O06555,InterPro:IPR003882,UniProtKB/TrEMBL:O06555,NCBI_GP:CCP43912.1;Name=CCP43912.1;Note=Rv1157c%2C (MTCI65.24c)%2C len: 371 aa. Conserved Ala-%2CPro-rich protein%2C similar to other proline rich proteins and extensins e.g. GBU04267|g451543 sea-island cotton proline-rich protein of cotton fiber (214 aa)%2C FASTA scores: opt: 305%2C E(): 3.9e-05%2C (35.7%25 identity in 182 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. First start taken. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1157c;product=Conserved ala-%2C pro-rich protein;protein_id=CCP43912.1;transl_table=11
AL123456.3	EMBL	gene	1283693	1283815	.	+	.	ID=gene-mcr10;Name=mcr10;gbkey=Gene;gene=mcr10;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1283693	1283815	.	+	.	ID=rna-mcr10;Parent=gene-mcr10;Note=mcr10%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped%2C ~~118 nt band detected by Northern blot.;gbkey=ncRNA;gene=mcr10;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1283693	1283815	.	+	.	ID=exon-mcr10-1;Parent=rna-mcr10;Note=mcr10%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped%2C ~~118 nt band detected by Northern blot.;gbkey=ncRNA;gene=mcr10;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1284179	1284862	.	-	.	ID=gene-Rv1158c;Name=Rv1158c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1158c
AL123456.3	EMBL	CDS	1284179	1284862	.	-	0	ID=cds-CCP43913.1;Parent=gene-Rv1158c;Dbxref=EnsemblGenomes-Gn:Rv1158c,EnsemblGenomes-Tr:CCP43913,GOA:O06556,UniProtKB/TrEMBL:O06556,NCBI_GP:CCP43913.1;Name=CCP43913.1;Note=Rv1158c%2C (MTCI65.25c)%2C len: 227 aa. Conserved hypothetical Ala-%2C Pro-rich protein%2C similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa)%2C FASTA scores: opt: 367%2C E(): 1.2e-08%2C(36.3%25 identity in 212 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1158c;product=Conserved hypothetical ala-%2C pro-rich protein;protein_id=CCP43913.1;transl_table=11
AL123456.3	EMBL	gene	1284992	1286287	.	+	.	ID=gene-Rv1159;Name=pimE;gbkey=Gene;gene=pimE;gene_biotype=protein_coding;locus_tag=Rv1159
AL123456.3	EMBL	CDS	1284992	1286287	.	+	0	ID=cds-CCP43914.1;Parent=gene-Rv1159;Dbxref=EnsemblGenomes-Gn:Rv1159,EnsemblGenomes-Tr:CCP43914,GOA:P9WN01,InterPro:IPR018584,NCBI_GP:CCP43914.1;Name=CCP43914.1;Note=Rv1159%2C (MTCI65.26)%2C len: 431 aa. PimE%2Cmannosyltransferase (see Morita et al.%2C 2006) Conserved transmembrane protein%2C similar to others in Mycobacterium tuberculosis e.g. Rv2181|MTCY21D4.13 (560 aa)%2C FASTA scores: opt: 172%3B E(): 0.00035%2C (25.0%25 identity in 332 aa overlap). Belongs to the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pimE;locus_tag=Rv1159;product=Mannosyltransferase PimE;protein_id=CCP43914.1;transl_table=11
AL123456.3	EMBL	gene	1286284	1286568	.	-	.	ID=gene-Rv1159A;Name=Rv1159A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1159A
AL123456.3	EMBL	CDS	1286284	1286568	.	-	0	ID=cds-CCP43915.1;Parent=gene-Rv1159A;Dbxref=EnsemblGenomes-Gn:Rv1159A,EnsemblGenomes-Tr:CCP43915,GOA:P9WI93,InterPro:IPR001533,NCBI_GP:CCP43915.1;Name=CCP43915.1;Note=Rv1159A%2C len: 94 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1159A;product=Unknown protein;protein_id=CCP43915.1;transl_table=11
AL123456.3	EMBL	gene	1286595	1287020	.	+	.	ID=gene-Rv1160;Name=mutT2;gbkey=Gene;gene=mutT2;gene_biotype=protein_coding;locus_tag=Rv1160
AL123456.3	EMBL	CDS	1286595	1287020	.	+	0	ID=cds-CCP43916.1;Parent=gene-Rv1160;Dbxref=EnsemblGenomes-Gn:Rv1160,EnsemblGenomes-Tr:CCP43916,GOA:P9WIY1,InterPro:IPR000086,InterPro:IPR015797,InterPro:IPR020084,InterPro:IPR020476,NCBI_GP:CCP43916.1;Name=CCP43916.1;Note=Rv1160%2C (MTCI65.27)%2C len: 141 aa. Probable mutT2%2Cmutator protein or homolog (see citation below). More similar to D908197|g1742860 MutT homolog from Escherichia coli (135 aa)%2C FASTA scores: opt: 226%2C E():1.1e-08%2C (39.7%25 identity in 116 aa overlap)%3B than to MUTT_ECOLI|P08337 mutator mutt protein from Escherichia coli (129 aa)%2C FASTA scores: opt: 180%2C E(): 1.2e-05%2C (27.1%25 identity in 129 aa overlap). Contains PS00893 mutT domain signature.;gbkey=CDS;gene=mutT2;inference=protein motif:PROSITE:PS00893;locus_tag=Rv1160;product=Probable mutator protein MutT2 (7%2C8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase);protein_id=CCP43916.1;transl_table=11
AL123456.3	EMBL	gene	1287328	1291026	.	+	.	ID=gene-Rv1161;Name=narG;gbkey=Gene;gene=narG;gene_biotype=protein_coding;locus_tag=Rv1161
AL123456.3	EMBL	CDS	1287328	1291026	.	+	0	ID=cds-CCP43917.1;Parent=gene-Rv1161;Dbxref=EnsemblGenomes-Gn:Rv1161,EnsemblGenomes-Tr:CCP43917,GOA:P9WJQ3,InterPro:IPR006468,InterPro:IPR006655,InterPro:IPR006656,InterPro:IPR006657,InterPro:IPR006963,InterPro:IPR009010,InterPro:IPR027467,NCBI_GP:CCP43917.1;Name=CCP43917.1;Note=Rv1161%2C (MTCI65.28)%2C len: 1232 aa. narG%2C respiratory nitrate reductase alpha chain. Similar to others e.g. NARG_BACSU nitratereductase alpha chain from Bacillus subtilis (1228 aa)%2C FASTA scores: opt: 4218%2C E(): 0%2C (50.3%25 identity in 1229 aa overlap)%3B etc. Also highly similar to N-terminal part of Rv1736c|MTCY04C12.21c|NARX probable nitrate reductase from Mycobacterium tuberculosis (85.1%25 identity in 281 aa overlap). Contains prokaryotic molybdopterin oxidoreductase signatures 1 and 2 (PS00551%2CPS00490). Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narG;inference=protein motif:PROSITE:PS00551;locus_tag=Rv1161;product=Respiratory nitrate reductase (alpha chain) NarG;protein_id=CCP43917.1;transl_table=11
AL123456.3	EMBL	gene	1291065	1292741	.	+	.	ID=gene-Rv1162;Name=narH;gbkey=Gene;gene=narH;gene_biotype=protein_coding;locus_tag=Rv1162
AL123456.3	EMBL	CDS	1291065	1292741	.	+	0	ID=cds-CCP43918.1;Parent=gene-Rv1162;Dbxref=EnsemblGenomes-Gn:Rv1162,EnsemblGenomes-Tr:CCP43918,GOA:O06560,InterPro:IPR006547,InterPro:IPR017896,InterPro:IPR029263,UniProtKB/TrEMBL:O06560,NCBI_GP:CCP43918.1;Name=CCP43918.1;Note=Rv1162%2C (MTCI65.29)%2C len: 558 aa. Probable narH%2Crespiratory nitrate reductase beta chain. Similar to others e.g. NARH_BACSU|P42176 nitrate reductase beta chain from Bacillus subtilis (487 aa)%2C FASTA scores: opt: 2049%2C E(): 0%2C (56.8%25 identity in 488 aa overlap)%3B etc. Contains PS00190 cytochrome c family heme-binding site signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narH;inference=protein motif:PROSITE:PS00190;locus_tag=Rv1162;product=Probable respiratory nitrate reductase (beta chain) NarH;protein_id=CCP43918.1;transl_table=11
AL123456.3	EMBL	gene	1292798	1293403	.	+	.	ID=gene-Rv1163;Name=narJ;gbkey=Gene;gene=narJ;gene_biotype=protein_coding;locus_tag=Rv1163
AL123456.3	EMBL	CDS	1292798	1293403	.	+	0	ID=cds-CCP43919.1;Parent=gene-Rv1163;Dbxref=EnsemblGenomes-Gn:Rv1163,EnsemblGenomes-Tr:CCP43919,GOA:O06561,InterPro:IPR003765,InterPro:IPR020945,UniProtKB/TrEMBL:O06561,NCBI_GP:CCP43919.1;Name=CCP43919.1;Note=Rv1163%2C (MTCI65.30)%2C len: 201 aa. Probable narJ%2Crespiratory nitrate reductase delta chain. Similar to others e.g. P42178|NARJ_BACSU nitrate reductase delta chain from Bacillus subtilis (184 aa)%2C FASTA scores: opt: 254%2CE(): 1.9e-10%2C (31.8%25 identity in 179 aa overlap)%3B etc. Strong similarity to region from aa 260 - 410 of Rv1736c|MTCY04C12.21c|NARX probable nitrate reductase from Mycobacterium tuberculosis (64.8%25 identity in 159 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narJ;locus_tag=Rv1163;product=Probable respiratory nitrate reductase (delta chain) NarJ;protein_id=CCP43919.1;transl_table=11
AL123456.3	EMBL	gene	1293406	1294146	.	+	.	ID=gene-Rv1164;Name=narI;gbkey=Gene;gene=narI;gene_biotype=protein_coding;locus_tag=Rv1164
AL123456.3	EMBL	CDS	1293406	1294146	.	+	0	ID=cds-CCP43920.1;Parent=gene-Rv1164;Dbxref=EnsemblGenomes-Gn:Rv1164,EnsemblGenomes-Tr:CCP43920,GOA:O06562,InterPro:IPR003816,InterPro:IPR023234,UniProtKB/TrEMBL:O06562,NCBI_GP:CCP43920.1;Name=CCP43920.1;Note=Rv1164%2C (MTCI65.31)%2C len: 246 aa. Probable narI%2Crespiratory nitrate reductase gamma chain. Similar to others e.g. NARI_BACSU|P42177 nitrate reductase gamma chain from Bacillus subtilis (223 aa)%2C FASTA scores: opt: 652%2CE(): 0%3B (41.6%25 identity in 221 aa overlap)%3B etc. Highly similar to C-terminal part of Rv1736c|MTCY04C12.21c|NARX probable nitrate reductase (gamma chain) from Mycobacterium tuberculosis (68.6%25 identity in 239 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narI;locus_tag=Rv1164;product=Probable respiratory nitrate reductase (gamma chain) NarI;protein_id=CCP43920.1;transl_table=11
AL123456.3	EMBL	gene	1294168	1296054	.	+	.	ID=gene-Rv1165;Name=typA;gbkey=Gene;gene=typA;gene_biotype=protein_coding;gene_synonym=bipA;locus_tag=Rv1165
AL123456.3	EMBL	CDS	1294168	1296054	.	+	0	ID=cds-CCP43921.1;Parent=gene-Rv1165;Dbxref=EnsemblGenomes-Gn:Rv1165,EnsemblGenomes-Tr:CCP43921,GOA:O06563,InterPro:IPR000640,InterPro:IPR000795,InterPro:IPR004161,InterPro:IPR005225,InterPro:IPR006298,InterPro:IPR009000,InterPro:IPR009022,InterPro:IPR027417,UniProtKB/TrEMBL:O06563,NCBI_GP:CCP43921.1;Name=CCP43921.1;Note=Rv1165%2C (MTV005.01-MTCI65.32)%2C len: 628 aa. Possible typA (alternate gene name: bipA)%2C GTP-binding translation elongation factor%2C similar to several e.g. P32132|TYPA_ECOLI|BIPA|B387 Escherichia coli (591 aa)%3B YIHK_SYNY3|P72749 gtp-binding protein TYPA/BIPA homolog from synechocystis sp. (597 aa)%2C FASTA scores: E(): 0%2C(46.9%25 identity in 610 aa overlap)%3B and to elongation factor EF-G from many organims e.g. EFG_MICLU|P09952 micrococcus luteus (701 aa)%2C FASTA scores: E(): 3e-24%2C(29.8%25 identity in 500 aa overlap). Belongs to the GTP-binding elongation factor family%2C TYPA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=typA;locus_tag=Rv1165;product=Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein);protein_id=CCP43921.1;transl_table=11
AL123456.3	EMBL	gene	1296152	1298059	.	+	.	ID=gene-Rv1166;Name=lpqW;gbkey=Gene;gene=lpqW;gene_biotype=protein_coding;locus_tag=Rv1166
AL123456.3	EMBL	CDS	1296152	1298059	.	+	0	ID=cds-CCP43922.1;Parent=gene-Rv1166;Dbxref=EnsemblGenomes-Gn:Rv1166,EnsemblGenomes-Tr:CCP43922,GOA:P9WGU7,InterPro:IPR000914,NCBI_GP:CCP43922.1;Name=CCP43922.1;Note=Rv1166%2C (MTV005.02)%2C len: 635 aa. Probable lpqW%2Cconserved lipoprotein%2C almost identical in part to G2384665|AF009358 Mycobacterium tuberculosis gene fragment ORFA2-898 (fragment) (59 aa) (93.9%25 identity in 49 aa overlap) (see * below). Also similar to Rv1280c and Rv2585c. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. [* Note: Unpublished. Identification of Mycobacterium tuberculosis peptides that stimulate immune human peripheral blood monocytes. Nano F.E.%2C Doran J.L.%2C Treit J.D.%2C Moran A.J.];experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqW;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1166;product=Probable conserved lipoprotein LpqW;protein_id=CCP43922.1;transl_table=11
AL123456.3	EMBL	gene	1298087	1298692	.	-	.	ID=gene-Rv1167c;Name=Rv1167c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1167c
AL123456.3	EMBL	CDS	1298087	1298692	.	-	0	ID=cds-CCP43923.1;Parent=gene-Rv1167c;Dbxref=EnsemblGenomes-Gn:Rv1167c,EnsemblGenomes-Tr:CCP43923,GOA:O50423,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O50423,NCBI_GP:CCP43923.1;Name=CCP43923.1;Note=Rv1167c%2C (MTV005.03c)%2C len: 201 aa. Probable transcriptional regulator%2C similar to several e.g. D1022772|D85417 hemR from Propionibacterium freudenreichii (243 aa)%2C FASTA scores: opt: 268%2C E(): 5.4e-16%2C (35.9%25 identity in 198 aa overlap) and AL022268|SC4H2.32 Streptomyces coelicolor (111 aa)%2C FASTA scores: opt: 274%2CE(): 5e-11%2C (55.1%25 identity in 89 aa overlap).;gbkey=CDS;locus_tag=Rv1167c;product=Probable transcriptional regulatory protein;protein_id=CCP43923.1;transl_table=11
AL123456.3	EMBL	gene	1298764	1299804	.	-	.	ID=gene-Rv1168c;Name=PPE17;gbkey=Gene;gene=PPE17;gene_biotype=protein_coding;locus_tag=Rv1168c
AL123456.3	EMBL	CDS	1298764	1299804	.	-	0	ID=cds-CCP43924.1;Parent=gene-Rv1168c;Dbxref=EnsemblGenomes-Gn:Rv1168c,EnsemblGenomes-Tr:CCP43924,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP43924.1;Name=CCP43924.1;Note=Rv1168c%2C (MTV005.04c)%2C len: 346 aa. PPE17%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa)%2C FASTA scores: opt: 504%2C E(): 0%2C (36.6%25 identity in 388 aa overlap).;gbkey=CDS;gene=PPE17;locus_tag=Rv1168c;product=PPE family protein PPE17;protein_id=CCP43924.1;transl_table=11
AL123456.3	EMBL	gene	1299822	1300124	.	-	.	ID=gene-Rv1169c;Name=lipX;gbkey=Gene;gene=lipX;gene_biotype=protein_coding;gene_synonym=PE11;locus_tag=Rv1169c
AL123456.3	EMBL	CDS	1299822	1300124	.	-	0	ID=cds-CCP43925.1;Parent=gene-Rv1169c;Dbxref=EnsemblGenomes-Gn:Rv1169c,EnsemblGenomes-Tr:CCP43925,GOA:Q79FR5,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FR5,NCBI_GP:CCP43925.1;Name=CCP43925.1;Note=Rv1169c%2C (MTV005.05c)%2C len: 100 aa. Possible lipX%2Clipase. Member of the Mycobacterium tuberculosis PE family of proteins (see Brennan %26 Delogu 2002)%2C e.g. O05297|Z93777|MTCI364.07 (99 aa)%2C FASTA scores: opt: 209%2CE(): 1.6e-15%2C (37.4%25 identity in 99 aa overlap). Also simlar to the N-terminus of P77909|U76006 esterase/lipase from Mycobacterium tuberculosis (437 aa)%2C FASTA scores: opt: 193%2C E(): 4.4e-14%2C (37.2%25 identity in 94 aa overlap). Contains a helix-turn-helix motif from aa 88-109 (+2.76 SD). Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipX;locus_tag=Rv1169c;product=PE family protein. Possible lipase LipX.;protein_id=CCP43925.1;transl_table=11
AL123456.3	EMBL	gene	1300304	1301215	.	+	.	ID=gene-Rv1170;Name=mshB;gbkey=Gene;gene=mshB;gene_biotype=protein_coding;locus_tag=Rv1170
AL123456.3	EMBL	CDS	1300304	1301215	.	+	0	ID=cds-CCP43926.1;Parent=gene-Rv1170;Dbxref=EnsemblGenomes-Gn:Rv1170,EnsemblGenomes-Tr:CCP43926,GOA:P9WJN3,InterPro:IPR003737,InterPro:IPR017810,InterPro:IPR024078,PDB:1Q74,PDB:1Q7T,PDB:4EWL,NCBI_GP:CCP43926.1;Name=CCP43926.1;Note=Rv1170%2C (MTV005.06)%2C len: 303 aa. MshB%2C N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase (GlcNAc-Ins deacetylase) (see citation below)%2Csimilar to Q54358|X79146 lmbE gene from Streptomyces lincolnensis (270 aa)%2C FASTA scores: opt: 308%2C E(): 1.2e-15%2C (32.0%25 identity in 278 aa overlap). Also similar to Rv1082|MCA Mycothiol conjugate amidase from Mycobacterium tuberculosis (288 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mshB;locus_tag=Rv1170;product=N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase);protein_id=CCP43926.1;transl_table=11
AL123456.3	EMBL	gene	1301307	1301747	.	+	.	ID=gene-Rv1171;Name=Rv1171;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1171
AL123456.3	EMBL	CDS	1301307	1301747	.	+	0	ID=cds-CCP43927.1;Parent=gene-Rv1171;Dbxref=EnsemblGenomes-Gn:Rv1171,EnsemblGenomes-Tr:CCP43927,UniProtKB/TrEMBL:O50427,NCBI_GP:CCP43927.1;Name=CCP43927.1;Note=Rv1171%2C (MTV005.07)%2C len: 146 aa. Conserved hypothetical protein%2C possibly transmembrane protein. Start has been changed since first submission.;gbkey=CDS;locus_tag=Rv1171;product=Conserved hypothetical protein;protein_id=CCP43927.1;transl_table=11
AL123456.3	EMBL	gene	1301755	1302681	.	-	.	ID=gene-Rv1172c;Name=PE12;gbkey=Gene;gene=PE12;gene_biotype=protein_coding;locus_tag=Rv1172c
AL123456.3	EMBL	CDS	1301755	1302681	.	-	0	ID=cds-CCP43928.1;Parent=gene-Rv1172c;Dbxref=EnsemblGenomes-Gn:Rv1172c,EnsemblGenomes-Tr:CCP43928,InterPro:IPR000084,UniProtKB/TrEMBL:L7N693,NCBI_GP:CCP43928.1;Name=CCP43928.1;Note=Rv1172c%2C (MTV005.08c)%2C len: 308 aa. PE12%2C Member of the Mycobacterium tuberculosis PE family of proteins (see Brennan %26 Delogu 2002)%2C e.g. P71748|Z81368|MTCY253.25C (361 aa)%2C FASTA scores: opt: 483%2C E(): 7.8e-22%2C (46.4%25 identity in 192 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE12;locus_tag=Rv1172c;product=PE family protein PE12;protein_id=CCP43928.1;transl_table=11
AL123456.3	EMBL	gene	1302931	1305501	.	+	.	ID=gene-Rv1173;Name=fbiC;gbkey=Gene;gene=fbiC;gene_biotype=protein_coding;locus_tag=Rv1173
AL123456.3	EMBL	CDS	1302931	1305501	.	+	0	ID=cds-CCP43929.1;Parent=gene-Rv1173;Dbxref=EnsemblGenomes-Gn:Rv1173,EnsemblGenomes-Tr:CCP43929,GOA:P9WP77,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR013785,InterPro:IPR019939,InterPro:IPR019940,InterPro:IPR020050,NCBI_GP:CCP43929.1;Name=CCP43929.1;Note=Rv1173%2C (MTV005.09)%2C len: 856 aa. Probable fbiC%2CF420 biosynthesis protein%2C equivalent to AAL91922|FBIC F420 biosynthesis protein fbiC from Mycobacterium bovis BCG (856 aa) (see citation below). The N-terminus (aa 80-420) is similar to Y446_METJA|Q57888 hypothetical protein mj0446 from methanococcus jannaschii (361 aa)%2C FASTA scores: opt: 801%2C E(): 0%2C (41.2%25 identity in 337 aa overlap)%3B and the C-terminus region (aa 530-856) is similar to e.g. YE31_METJA|Q58826 hypothetical protein mj1431 from methanococcus jannaschii (359 aa)%2C FASTA scores: opt: 1089%2CE(): 0%2C (48.7%25 identity in 337 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fbiC;locus_tag=Rv1173;product=Probable F420 biosynthesis protein FbiC;protein_id=CCP43929.1;transl_table=11
AL123456.3	EMBL	repeat_region	1305495	1305556	.	+	.	ID=id-AL123456.3:1305495..1305556;Note=62 bp direct repeat copy 1%2C GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCA ATCT;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	1305557	1305618	.	+	.	ID=id-AL123456.3:1305557..1305618;Note=62 bp direct repeat copy 2%2C GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCA ATCT;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	1305619	1305661	.	+	.	ID=id-AL123456.3:1305619..1305661;Note=62 bp direct repeat partial copy 3 (43/62 bp)%2CGGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGGGGCCCG;gbkey=repeat_region
AL123456.3	EMBL	gene	1305669	1306001	.	-	.	ID=gene-Rv1174c;Name=TB8.4;gbkey=Gene;gene=TB8.4;gene_biotype=protein_coding;locus_tag=Rv1174c
AL123456.3	EMBL	CDS	1305669	1306001	.	-	0	ID=cds-CCP43930.1;Parent=gene-Rv1174c;Dbxref=EnsemblGenomes-Gn:Rv1174c,EnsemblGenomes-Tr:CCP43930,GOA:O50430,InterPro:IPR016572,UniProtKB/TrEMBL:O50430,NCBI_GP:CCP43930.1;Name=CCP43930.1;Note=Rv1174c%2C (MTV005.10c)%2C len: 110 aa. TB8.4%2C low molecular weight T-cell antigen (see citations below)%2Chypothetical unknown secreted protein. Predicted to be an outer membrane protein (See Song et al.%2C 2008). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB8.4;locus_tag=Rv1174c;product=Low molecular weight T-cell antigen TB8.4;protein_id=CCP43930.1;transl_table=11
AL123456.3	EMBL	gene	1306202	1308226	.	-	.	ID=gene-Rv1175c;Name=fadH;gbkey=Gene;gene=fadH;gene_biotype=protein_coding;locus_tag=Rv1175c
AL123456.3	EMBL	CDS	1306202	1308226	.	-	0	ID=cds-CCP43931.1;Parent=gene-Rv1175c;Dbxref=EnsemblGenomes-Gn:Rv1175c,EnsemblGenomes-Tr:CCP43931,GOA:O50431,InterPro:IPR001155,InterPro:IPR001327,InterPro:IPR013027,InterPro:IPR013785,InterPro:IPR023753,UniProtKB/TrEMBL:O50431,NCBI_GP:CCP43931.1;Name=CCP43931.1;Note=Rv1175c%2C (MTV005.11c)%2C len: 674 aa. Probable fadH%2CNADPH-dependent 2%2C4-dienoyl-CoA reductase%2C highly similar to others e.g. NP_251782.1|NC_002516 2%2C4-dienoyl-CoA reductase FadH1 from Pseudomonas aeruginosa (679 aa)%3B CAC01564.1|AL391039 2%2C4-dienoyl-CoA reductase [NADPH] from Streptomyces coelicolor (671 aa)%3B P42593|FADH_ECOLI 2%2C4-dienoyl-CoA reductase from Escherichia coli (671 aa)%2CFASTA scores: opt: 2344%2C E(): 0%2C (53.1%25 identity in 671 aa overlap)%3B etc. Also similar to Rv3359|MTV004.16 putative oxidoreductase from Mycobacterium tuberculosis (396 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadH;locus_tag=Rv1175c;product=Probable NADPH dependent 2%2C4-dienoyl-CoA reductase FadH (2%2C4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase);protein_id=CCP43931.1;transl_table=11
AL123456.3	EMBL	gene	1308223	1308792	.	-	.	ID=gene-Rv1176c;Name=Rv1176c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1176c
AL123456.3	EMBL	CDS	1308223	1308792	.	-	0	ID=cds-CCP43932.1;Parent=gene-Rv1176c;Dbxref=EnsemblGenomes-Gn:Rv1176c,EnsemblGenomes-Tr:CCP43932,GOA:O50432,InterPro:IPR005149,InterPro:IPR011991,InterPro:IPR018309,UniProtKB/TrEMBL:O50432,NCBI_GP:CCP43932.1;Name=CCP43932.1;Note=Rv1176c%2C (MTV005.12c)%2C len: 189 aa. Conserved hypothetical protein%2C some similarity to P94443|D78508 hypothetical protein from Bacillus subtilis (182 aa)%2C FASTA scores: opt: 219%2C E(): 1.7e-15%2C (25.1%25 identity in 183 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv0047c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1176c;product=Conserved hypothetical protein;protein_id=CCP43932.1;transl_table=11
AL123456.3	EMBL	gene	1309005	1309331	.	+	.	ID=gene-Rv1177;Name=fdxC;gbkey=Gene;gene=fdxC;gene_biotype=protein_coding;locus_tag=Rv1177
AL123456.3	EMBL	CDS	1309005	1309331	.	+	0	ID=cds-CCP43933.1;Parent=gene-Rv1177;Dbxref=EnsemblGenomes-Gn:Rv1177,EnsemblGenomes-Tr:CCP43933,GOA:O50433,InterPro:IPR000813,InterPro:IPR001450,InterPro:IPR017896,InterPro:IPR017900,UniProtKB/TrEMBL:O50433,NCBI_GP:CCP43933.1;Name=CCP43933.1;Note=Rv1177%2C (MTV005.13)%2C len: 108 aa. Probable fdxC%2Cferredoxin%2C equivalent to NP_302047.1|NC_002677 ferredoxin from Mycobacterium leprae (108 aa)%3B P00215|FER_MYCSM ferredoxin from Mycobacterium smegmatis (106 aa)%2C FASTA scores: opt: 705%2C E(): 0%2C (87.7%25 identity in 106 aa overlap). Also highly similar to many e.g. JH0239 ferredoxin precursor from Saccharopolyspora erythraea (105 aa)%3B P24496|FER_SACER ferredoxin from Saccharopolyspora erythraea (106 aa)%3B etc. Contains PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature. Belongs to the bacterial type ferredoxin family. Cofactor: binds 1 4FE-4S cluster and a 3FE-4S cluster (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fdxC;inference=protein motif:PROSITE:PS00198;locus_tag=Rv1177;product=Probable ferredoxin FdxC;protein_id=CCP43933.1;transl_table=11
AL123456.3	EMBL	gene	1309364	1310452	.	+	.	ID=gene-Rv1178;Name=Rv1178;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1178
AL123456.3	EMBL	CDS	1309364	1310452	.	+	0	ID=cds-CCP43934.1;Parent=gene-Rv1178;Dbxref=EnsemblGenomes-Gn:Rv1178,EnsemblGenomes-Tr:CCP43934,GOA:O50434,InterPro:IPR004838,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR019880,UniProtKB/TrEMBL:O50434,NCBI_GP:CCP43934.1;Name=CCP43934.1;Note=Rv1178%2C (MTV005.14)%2C len: 362 aa. Probable aminotransferase%2C weak similarity to many aspartate aminotransferases e.g. Q55679|D64000 SLL0006 aspartate aminotransferase from Synechocystis sp. (394 aa)%2C FASTA scores: opt: 218%2C E(): 1.3e-25%2C (32.5%25 identity in 379 aa overlap). Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. Also similar to Mycobacterium tuberculosis aminotransferases Rv2294%2CRv0075%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00105;locus_tag=Rv1178;product=Probable aminotransferase;protein_id=CCP43934.1;transl_table=11
AL123456.3	EMBL	gene	1310480	1313299	.	-	.	ID=gene-Rv1179c;Name=Rv1179c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1179c
AL123456.3	EMBL	CDS	1310480	1313299	.	-	0	ID=cds-CCP43935.1;Parent=gene-Rv1179c;Dbxref=EnsemblGenomes-Gn:Rv1179c,EnsemblGenomes-Tr:CCP43935,GOA:O50435,InterPro:IPR001650,InterPro:IPR006935,InterPro:IPR014001,InterPro:IPR027417,UniProtKB/TrEMBL:O50435,NCBI_GP:CCP43935.1;Name=CCP43935.1;Note=Rv1179c%2C MTV005.15c%2C len: 939 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1179c;product=Unknown protein;protein_id=CCP43935.1;transl_table=11
AL123456.3	EMBL	gene	1313725	1315191	.	+	.	ID=gene-Rv1180;Name=pks3;gbkey=Gene;gene=pks3;gene_biotype=protein_coding;locus_tag=Rv1180
AL123456.3	EMBL	CDS	1313725	1315191	.	+	0	ID=cds-CCP43936.1;Parent=gene-Rv1180;Dbxref=EnsemblGenomes-Gn:Rv1180,EnsemblGenomes-Tr:CCP43936,GOA:L0T5X5,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR018201,InterPro:IPR020841,UniProtKB/TrEMBL:L0T5X5,NCBI_GP:CCP43936.1;Name=CCP43936.1;Note=Rv1180%2C (MTV005.16)%2C len: 488 aa. Probable polyketide beta-ketoacyl synthase%2C equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below)%2C and similar to the N-terminus of many polyketide synthases e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from Mycobacterium bovis (2110 aa)%2C FASTA scores: opt: 2115%2C E(): 0%2C (66.5%25 identity in 472 aa overlap). Also similar to%2C and same length as P96284|Z83858|MTCY24G1.02 M. tuberculosis (496 aa)%2C FASTA scores: opt: 1424%2C E(): 0%2C (50.9%25 identity in 444 aa overlap). Contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2Calso PS00606 Beta-ketoacyl synthases active site. Belongs to the beta-ketoacyl-ACP synthases family. Alternative nucleotide at position 1315191 (a->C%3B Stop489Y) has been observed. Rv1180/Rv1181 fusion has been called msl3.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks3;inference=protein motif:PROSITE:PS00606;locus_tag=Rv1180;product=Probable polyketide beta-ketoacyl synthase Pks3;protein_id=CCP43936.1;transl_table=11
AL123456.3	EMBL	gene	1315234	1319982	.	+	.	ID=gene-Rv1181;Name=pks4;gbkey=Gene;gene=pks4;gene_biotype=protein_coding;locus_tag=Rv1181
AL123456.3	EMBL	CDS	1315234	1319982	.	+	0	ID=cds-CCP43937.1;Parent=gene-Rv1181;Dbxref=EnsemblGenomes-Gn:Rv1181,EnsemblGenomes-Tr:CCP43937,GOA:L0T647,InterPro:IPR001227,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR013968,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016040,InterPro:IPR020801,InterPro:IPR020807,InterPro:IPR020842,InterPro:IPR020843,UniProtKB/TrEMBL:L0T647,NCBI_GP:CCP43937.1;Name=CCP43937.1;Note=Rv1181%2C (MTV005.17)%2C len: 1582 aa. Probable pks4%2Cpolyketide synthase%2C similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from Mycobacterium bovis (2110 aa)%2C FASTA scores: opt: 3518%2C E(): 0%2C (59.7%25 identity in 1614 aa overlap). Note that this similarity extends upstream of the first initiation codon into the upstream MTV005.16%3B the stop codon at the end of MTV005.16 is present in at least 4 independent clones (BAC%2C cosmid and pUC) from the genome (however an alternative nucleotide at position 1315191 (a->C%3B Stop489Y) has also been observed). The two CDS's may represent separate modules of the polyketide synthase. Rv1180/Rv1181 fusion has been called msl3.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks4;locus_tag=Rv1181;product=Probable polyketide beta-ketoacyl synthase Pks4;protein_id=CCP43937.1;transl_table=11
AL123456.3	EMBL	gene	1320035	1321453	.	+	.	ID=gene-Rv1182;Name=papA3;gbkey=Gene;gene=papA3;gene_biotype=protein_coding;locus_tag=Rv1182
AL123456.3	EMBL	CDS	1320035	1321453	.	+	0	ID=cds-CCP43938.1;Parent=gene-Rv1182;Dbxref=EnsemblGenomes-Gn:Rv1182,EnsemblGenomes-Tr:CCP43938,GOA:P9WIK5,InterPro:IPR001242,NCBI_GP:CCP43938.1;Name=CCP43938.1;Note=Rv1182%2C (MTV005.18)%2C len: 472 aa. Probable papA3%2Cconserved polyketide synthase (PKS) associated protein%2Csimilar to other Mycobacterial hypothetical proteins e.g. Q49618|U00010 B1170_C1_180 from Mycobacterium leprae (471 aa)%2C FASTA scores: opt: 2526%2C E(): 0%2C (75.6%25 identity in 471 aa overlap). Similar to other Mycobacterium tuberculosis hypothetical papA proteins%3B Rv3824c%2C Rv3820c%2CRv1528c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=papA3;locus_tag=Rv1182;product=Probable conserved polyketide synthase associated protein PapA3;protein_id=CCP43938.1;transl_table=11
AL123456.3	EMBL	gene	1321520	1324528	.	+	.	ID=gene-Rv1183;Name=mmpL10;gbkey=Gene;gene=mmpL10;gene_biotype=protein_coding;locus_tag=Rv1183
AL123456.3	EMBL	CDS	1321520	1324528	.	+	0	ID=cds-CCP43939.1;Parent=gene-Rv1183;Dbxref=EnsemblGenomes-Gn:Rv1183,EnsemblGenomes-Tr:CCP43939,GOA:P9WJU1,InterPro:IPR004707,InterPro:IPR004869,NCBI_GP:CCP43939.1;Name=CCP43939.1;Note=Rv1183%2C (MTV005.19)%2C len: 1002 aa. Probable mmpL10%2Cconserved transmembrane transport protein (see Tekaia et al.%2C 1999)%2C member of RND superfamily%2C similar to many Mycobacterial hypothetical membrane proteins e.g. Q49619|U00010 from Mycobacterium leprae (1008 aa)%2C FASTA scores: opt: 4545%2C E(): 0%2C (70.6%25 identity in 978 aa overlap)%3B etc. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL10;locus_tag=Rv1183;product=Probable conserved transmembrane transport protein MmpL10;protein_id=CCP43939.1;transl_table=11
AL123456.3	EMBL	gene	1324532	1325611	.	-	.	ID=gene-Rv1184c;Name=Rv1184c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1184c
AL123456.3	EMBL	CDS	1324532	1325611	.	-	0	ID=cds-CCP43940.1;Parent=gene-Rv1184c;Dbxref=EnsemblGenomes-Gn:Rv1184c,EnsemblGenomes-Tr:CCP43940,GOA:O50440,InterPro:IPR013228,UniProtKB/TrEMBL:O50440,NCBI_GP:CCP43940.1;Name=CCP43940.1;Note=Rv1184c%2C (MTV005.20c)%2C len: 359 aa. Possible exported protein with potential N-terminal signal sequence. Similar to several Mycobacterial hypothetical proteins e.g. Q49633|U00010 Protein B1170_F3_112 from M. leprae (391 aa)%2CFASTA scores: opt: 1422%2C E(): 0%2C (62.7%25 identity in 338 aa overlap). Also similar to Rv3822%2C Rv3539%2C Rv1430%2C Rv0151c%2Cetc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1184c;product=Possible exported protein;protein_id=CCP43940.1;transl_table=11
AL123456.3	EMBL	gene	1325776	1327512	.	-	.	ID=gene-Rv1185c;Name=fadD21;gbkey=Gene;gene=fadD21;gene_biotype=protein_coding;locus_tag=Rv1185c
AL123456.3	EMBL	CDS	1325776	1327512	.	-	0	ID=cds-CCP43941.1;Parent=gene-Rv1185c;Dbxref=EnsemblGenomes-Gn:Rv1185c,EnsemblGenomes-Tr:CCP43941,GOA:P9WQ49,InterPro:IPR000873,NCBI_GP:CCP43941.1;Name=CCP43941.1;Note=Rv1185c%2C (MTV005.21c)%2C len: 578 aa. Probable fadD21%2Cfatty-acid-AMP synthetase%2C highly similar to several from Mycobacteria e.g. NP_301895.1|NC_002677 possible acyl-CoA synthase from Mycobacterium leprae (579 aa)%3B P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa)%2C FASTA scores: opt: 2388%2C E(): 0%2C (61.8%25 identity in 579 aa overlap)%3B etc. Seems to belong to the ATP-dependent AMP-binding enzyme family. Nucleotide position 1327402 in the genome sequence has been corrected%2C T:C resulting in E37E.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD21;locus_tag=Rv1185c;product=Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP43941.1;transl_table=11
AL123456.3	EMBL	gene	1327689	1329305	.	-	.	ID=gene-Rv1186c;Name=Rv1186c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1186c
AL123456.3	EMBL	CDS	1327689	1329305	.	-	0	ID=cds-CCP43942.1;Parent=gene-Rv1186c;Dbxref=EnsemblGenomes-Gn:Rv1186c,EnsemblGenomes-Tr:CCP43942,GOA:O50442,InterPro:IPR025736,UniProtKB/TrEMBL:O50442,NCBI_GP:CCP43942.1;Name=CCP43942.1;Note=Rv1186c%2C (MTV005.22c)%2C len: 538 aa. Conserved protein%2C similar to AL117385|SC5G9.24 hypothetical protein from Streptomyces coelicolor (555 aa)%2C FASTA scores: opt: 485%2C E(): 2.3e-23%2C (32.6%25 identity in 568 aa overlap). Contains helix turn helix motif from aa 488-509 (+2.81 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1186c;product=Conserved protein;protein_id=CCP43942.1;transl_table=11
AL123456.3	EMBL	gene	1329390	1331021	.	+	.	ID=gene-Rv1187;Name=rocA;gbkey=Gene;gene=rocA;gene_biotype=protein_coding;locus_tag=Rv1187
AL123456.3	EMBL	CDS	1329390	1331021	.	+	0	ID=cds-CCP43943.1;Parent=gene-Rv1187;Dbxref=EnsemblGenomes-Gn:Rv1187,EnsemblGenomes-Tr:CCP43943,GOA:O50443,InterPro:IPR005931,InterPro:IPR015590,InterPro:IPR016160,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,PDB:4IDM,PDB:4IDS,PDB:4IHI,PDB:4JDC,PDB:4LEM,UniProtKB/TrEMBL:O50443,NCBI_GP:CCP43943.1;Name=CCP43943.1;Note=Rv1187%2C (MTV005.23)%2C len: 543 aa. Probable rocA%2Cpyrroline-5-carboxylate dehydrogenase%2C similar to many e.g. PUT2_HUMAN|P30038 human delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa)%2C FASTA scores: opt: 1596%2C E():0%2C(46.0%25 identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv0768%2C Rv2858c%2C etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rocA;locus_tag=Rv1187;product=Probable pyrroline-5-carboxylate dehydrogenase RocA;protein_id=CCP43943.1;transl_table=11
AL123456.3	EMBL	gene	1331021	1332010	.	+	.	ID=gene-Rv1188;Name=Rv1188;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1188
AL123456.3	EMBL	CDS	1331021	1332010	.	+	0	ID=cds-CCP43944.1;Parent=gene-Rv1188;Dbxref=EnsemblGenomes-Gn:Rv1188,EnsemblGenomes-Tr:CCP43944,GOA:O50444,InterPro:IPR002872,InterPro:IPR008219,InterPro:IPR029041,UniProtKB/TrEMBL:O50444,NCBI_GP:CCP43944.1;Name=CCP43944.1;Note=Rv1188%2C (MTV005.24)%2C len: 329 aa. Possible putA%2Cproline dehydrogenase%2C similar to part of Q52711|X78346 proline dehydrogenase from Rhodobacter capsulatus (1127 aa)%2C FASTA scores: opt: 194%2C E(): 1.5e-07%2C (31.2%25 identity in 349 aa overlap). Also similar to two Bacillus subtilis proline dehydrohenases E1184363|Z99120 (302 aa)%2C FASTA scores: opt: 509%2C E(): 0%2C (37.1%25 identity in 313 aa overlap)%3B and E1182272|Z99105 (303 aa)%2C FASTA scores: opt: 513%2C E(): 0%2C (32.5%25 identity in 311 aa overlap). Highly similar to AL035569|SC8D9.31 Streptomyces coelicolor (308 aa)%2C FASTA scores: opt: 984%2C E(): 0%2C (50.0%25 identity in 312 aa overlap). Nucleotide position 1331696 in the genome sequence has been corrected%2C A:C resulting in R226R.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1188;product=Probable proline dehydrogenase;protein_id=CCP43944.1;transl_table=11
AL123456.3	EMBL	gene	1332092	1332964	.	+	.	ID=gene-Rv1189;Name=sigI;gbkey=Gene;gene=sigI;gene_biotype=protein_coding;locus_tag=Rv1189
AL123456.3	EMBL	CDS	1332092	1332964	.	+	0	ID=cds-CCP43945.1;Parent=gene-Rv1189;Dbxref=EnsemblGenomes-Gn:Rv1189,EnsemblGenomes-Tr:CCP43945,GOA:P9WGH3,InterPro:IPR007627,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,NCBI_GP:CCP43945.1;Name=CCP43945.1;Note=Rv1189%2C (MTV005.25-MTCI364.01)%2C len: 290 aa. Possible sigI%2C alternative RNA polymerase sigma factor (see Gomez et al.%2C 1997%3B Chen et al.%2C 2000)%2C similar to several e.g. O05767|U87307 extracytoplasmic function alternative sigma factor (sigE) from Mycobacterium smegmatis (204 aa)%2CFASTA scores: opt: 239%2C E(): 1.3e-09%2C (32.9%25 identity in 167 aa overlap).;gbkey=CDS;gene=sigI;locus_tag=Rv1189;product=Possible alternative RNA polymerase sigma factor SigI;protein_id=CCP43945.1;transl_table=11
AL123456.3	EMBL	gene	1332980	1333858	.	+	.	ID=gene-Rv1190;Name=Rv1190;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1190
AL123456.3	EMBL	CDS	1332980	1333858	.	+	0	ID=cds-CCP43946.1;Parent=gene-Rv1190;Dbxref=EnsemblGenomes-Gn:Rv1190,EnsemblGenomes-Tr:CCP43946,InterPro:IPR029058,UniProtKB/TrEMBL:O86348,NCBI_GP:CCP43946.1;Name=CCP43946.1;Note=Rv1190%2C (MTCI364.02)%2C len: 292 aa. Conserved hypothetical protein%2C similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa)%2C fasta scores: opt: 331%2C E(): 1.4e-15%2C (29.0%25 identity in 272 aa overlap)%2C also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa)%2C FASTA scores: opt: 239%2C E(): 2.2e-09%2C (29.9%25 identity in 298 aa overlap).;gbkey=CDS;locus_tag=Rv1190;product=Conserved hypothetical protein;protein_id=CCP43946.1;transl_table=11
AL123456.3	EMBL	gene	1333931	1334845	.	+	.	ID=gene-Rv1191;Name=Rv1191;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1191
AL123456.3	EMBL	CDS	1333931	1334845	.	+	0	ID=cds-CCP43947.1;Parent=gene-Rv1191;Dbxref=EnsemblGenomes-Gn:Rv1191,EnsemblGenomes-Tr:CCP43947,InterPro:IPR029058,UniProtKB/TrEMBL:O05293,NCBI_GP:CCP43947.1;Name=CCP43947.1;Note=Rv1191%2C (MTCI364.03)%2C len: 304 aa. Conserved protein%2C similar to Q54528 RDMC from Streptomyces purpurascens (298 aa)%2C FASTA scores: opt: 196%2C E(): 1.5e-05%2C (27.5%25 identity in 269 aa overlap)%3B Rv0134|MTCI5.08 (300 aa)%2C FASTA scores: opt: 197%2C E(): 6.6e-06%2C (26.4%25 identity in 299 aa overlap)%2C some similarity to PIP_NEIGO|P42786 proline iminopeptidase (310 aa)%2C FASTA scores: opt: 196%2C E(): 1.3e-05%2C (32.2%25 identity in 152 aa overlap). Contains PS00044 Bacterial regulatory proteins%2C lysR family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv1191;product=Conserved protein;protein_id=CCP43947.1;transl_table=11
AL123456.3	EMBL	gene	1334927	1335754	.	+	.	ID=gene-Rv1192;Name=Rv1192;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1192
AL123456.3	EMBL	CDS	1334927	1335754	.	+	0	ID=cds-CCP43948.1;Parent=gene-Rv1192;Dbxref=EnsemblGenomes-Gn:Rv1192,EnsemblGenomes-Tr:CCP43948,GOA:O05294,InterPro:IPR029058,UniProtKB/TrEMBL:O05294,NCBI_GP:CCP43948.1;Name=CCP43948.1;Note=Rv1192%2C (MTCI364.04)%2C len: 275 aa. Unknown protein%2Ccontains PS00120 lipases%2C serine active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv1192;product=Unknown protein;protein_id=CCP43948.1;transl_table=11
AL123456.3	EMBL	gene	1335794	1337215	.	+	.	ID=gene-Rv1193;Name=fadD36;gbkey=Gene;gene=fadD36;gene_biotype=protein_coding;locus_tag=Rv1193
AL123456.3	EMBL	CDS	1335794	1337215	.	+	0	ID=cds-CCP43949.1;Parent=gene-Rv1193;Dbxref=EnsemblGenomes-Gn:Rv1193,EnsemblGenomes-Tr:CCP43949,GOA:O05295,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O05295,NCBI_GP:CCP43949.1;Name=CCP43949.1;Note=Rv1193%2C (MTCI364.05)%2C len: 473 aa. Probable fadD36%2Cfatty-acid-CoA synthetase%2C highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa)%2CFASTA scores: opt: 2594%2C E(): 0%2C (81.3%25 identity in 476 aa overlap). Also highly similar to others e.g. CAB86109.1|AL163003 putative fatty acid synthase from Streptomyces coelicolor (485 aa)%3B LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa)%2C FASTA scores: opt: 605%2C E(): 8.4e-30%2C (33.0%25 identity in 364 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD36;inference=protein motif:PROSITE:PS00455;locus_tag=Rv1193;product=Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP43949.1;transl_table=11
AL123456.3	EMBL	gene	1337248	1338513	.	-	.	ID=gene-Rv1194c;Name=Rv1194c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1194c
AL123456.3	EMBL	CDS	1337248	1338513	.	-	0	ID=cds-CCP43950.1;Parent=gene-Rv1194c;Dbxref=EnsemblGenomes-Gn:Rv1194c,EnsemblGenomes-Tr:CCP43950,GOA:O05296,InterPro:IPR025736,UniProtKB/TrEMBL:O05296,NCBI_GP:CCP43950.1;Name=CCP43950.1;Note=Rv1194c%2C (MTCI364.06c)%2C len: 421 aa. Conserved protein%2C highly similar to Q50018 possible transcriptional activator from Mycobacterium leprae (517 aa)%2C FASTA scores: opt: 1960%2C E(): 0%2C (69.8%25 identity in 421 aa overlap). Also similar to Mycobacterium tuberculosis Rv2370c|MTCY27.10%2C(62.0%25 identity in 421 aa overlap) and Rv1453|MTCY493.01c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1194c;product=Conserved protein;protein_id=CCP43950.1;transl_table=11
AL123456.3	EMBL	gene	1339003	1339302	.	+	.	ID=gene-Rv1195;Name=PE13;gbkey=Gene;gene=PE13;gene_biotype=protein_coding;locus_tag=Rv1195
AL123456.3	EMBL	CDS	1339003	1339302	.	+	0	ID=cds-CCP43951.1;Parent=gene-Rv1195;Dbxref=EnsemblGenomes-Gn:Rv1195,EnsemblGenomes-Tr:CCP43951,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FR3,NCBI_GP:CCP43951.1;Name=CCP43951.1;Note=Rv1195%2C (MTCI364.07)%2C len: 99 aa. PE13%2C Member of Mycobacterium tuberculosis PE family (see Brennan %26 Delogu 2002)%2C e.g. Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kd protein (498 aa)%2C FASTA scores: opt: 307%2C E(): 1.4e-12%2C (56.3%25 identity in 96 aa overlap)%2C similar to MTCY21C12.10c (99 aa)%2C FASTA scores: opt:295%2C E(): 1.9e-11%2C(51.5%25 identity in 97 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE13;locus_tag=Rv1195;product=PE family protein PE13;protein_id=CCP43951.1;transl_table=11
AL123456.3	EMBL	gene	1339349	1340524	.	+	.	ID=gene-Rv1196;Name=PPE18;gbkey=Gene;gene=PPE18;gene_biotype=protein_coding;gene_synonym=mtb39a;locus_tag=Rv1196
AL123456.3	EMBL	CDS	1339349	1340524	.	+	0	ID=cds-CCP43952.1;Parent=gene-Rv1196;Dbxref=EnsemblGenomes-Gn:Rv1196,EnsemblGenomes-Tr:CCP43952,InterPro:IPR000030,InterPro:IPR022171,UniProtKB/TrEMBL:L7N675,NCBI_GP:CCP43952.1;Name=CCP43952.1;Note=Rv1196%2C (MTCI364.08)%2C len: 391 aa. PPE18 (alternate gene name: mtb39a). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C highly similar to others e.g. Y07P_MYCTU|Q11031 hypothetical 40.0 kDa protein cy02b10.25c (396 aa)%2C FASTA scores: opt: 2124%2CE(): 0%2C (85.1%25 identity in 397 aa overlap). Note that expression of Rv1196 was demonstrated in lysates by immunodetection (see Dillon et al.%2C 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE18;locus_tag=Rv1196;product=PPE family protein PPE18;protein_id=CCP43952.1;transl_table=11
AL123456.3	EMBL	gene	1340578	1340625	.	+	.	ID=gene-ncrMT1234;Name=ncrMT1234;gbkey=Gene;gene=ncrMT1234;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1340578	1340625	.	+	.	ID=rna-ncrMT1234;Parent=gene-ncrMT1234;Note=ncrMT1234%2C fragment of putative small regulatory RNA (See Pelly et al.%2C 2012)%2C cloned from M. tuberculosis CDC1551%3B supported by RNA-seq in H37Rv (unpublished data).;gbkey=ncRNA;gene=ncrMT1234;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	1340578	1340625	.	+	.	ID=exon-ncrMT1234-1;Parent=rna-ncrMT1234;Note=ncrMT1234%2C fragment of putative small regulatory RNA (See Pelly et al.%2C 2012)%2C cloned from M. tuberculosis CDC1551%3B supported by RNA-seq in H37Rv (unpublished data).;gbkey=ncRNA;gene=ncrMT1234;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	1340659	1340955	.	+	.	ID=gene-Rv1197;Name=esxK;gbkey=Gene;gene=esxK;gene_biotype=protein_coding;gene_synonym=ES6_3,QILSS,TB11.0;locus_tag=Rv1197
AL123456.3	EMBL	CDS	1340659	1340955	.	+	0	ID=cds-CCP43953.1;Parent=gene-Rv1197;Dbxref=EnsemblGenomes-Gn:Rv1197,EnsemblGenomes-Tr:CCP43953,GOA:P9WNJ7,InterPro:IPR010310,NCBI_GP:CCP43953.1;Name=CCP43953.1;Note=Rv1197%2C (MT1235%2C MTCI364.09)%2C len: 98 aa. EsxK%2CESAT-6 like protein (see citation below). Member of M. tuberculosis hypothetical QILSS protein family with Rv1038c%2C etc. Almost identical to MTCY98.023c (98 aa) (99.0%25 identity in 98 aa overlap) and MTCY10G2.11 (98 aa)%2CFASTA scores: opt: 643%2C E(): 0%2C (99.0%25 identity in 98 aa overlap)%3B highly similar to Q49945|U1756C from Mycobacterium leprae (100 aa)%2C FASTA scores: opt: 377%2C E(): 8e-21%2C (58.3%25 identity in 96 aa overlap). Belongs to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxK;locus_tag=Rv1197;product=ESAT-6 like protein EsxK (ESAT-6 like protein 3);protein_id=CCP43953.1;transl_table=11
AL123456.3	EMBL	gene	1341006	1341290	.	+	.	ID=gene-Rv1198;Name=esxL;gbkey=Gene;gene=esxL;gene_biotype=protein_coding;gene_synonym=ES6_4,Mtb9.9C;locus_tag=Rv1198
AL123456.3	EMBL	CDS	1341006	1341290	.	+	0	ID=cds-CCP43954.1;Parent=gene-Rv1198;Dbxref=EnsemblGenomes-Gn:Rv1198,EnsemblGenomes-Tr:CCP43954,GOA:P9WNJ5,InterPro:IPR009416,InterPro:IPR010310,NCBI_GP:CCP43954.1;Name=CCP43954.1;Note=Rv1198%2C (MT1236%2C MTCI364.10)%2C len: 94 aa. EsxL%2CESAT-6 like protein (see citation below). Member of the ESAT-6 family with Rv3619c%2C Rv1037c%2C etc. Almost identical to MTCY10G2.12 (94 aa) (97.9%25 identity in 94 aa overlap) and MTCY98.022c (94 aa) (94.7%25 identity in 94 aa overlap). Highly similar to Q49946|U1756D Mycobacterium leprae (95 aa)%2C FASTA scores: opt: 403%2C E(): 1.1e-22%2C (64.1%25 identity in 92 aa overlap). seems to belong to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxL;locus_tag=Rv1198;product=Putative ESAT-6 like protein EsxL (ESAT-6 like protein 4);protein_id=CCP43954.1;transl_table=11
AL123456.3	EMBL	gene	1341358	1342605	.	-	.	ID=gene-Rv1199c;Name=Rv1199c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1199c
AL123456.3	EMBL	CDS	1341358	1342605	.	-	0	ID=cds-CCP43955.1;Parent=gene-Rv1199c;Dbxref=EnsemblGenomes-Gn:Rv1199c,EnsemblGenomes-Tr:CCP43955,GOA:P60230,InterPro:IPR001207,NCBI_GP:CCP43955.1;Name=CCP43955.1;Note=Rv1199c%2C (MTCI364.11c)%2C len: 415 aa. Possible transposase for IS1081%2C identical to TRA1_MYCBO|P35882 transposase for insertion sequence element (415 aa)%3B region identical to MTCY441.35 (100.0%25 identity in 261 aa overlap)%3B and almost identical to MTCY10G2.02c (415 aa) (99.8%25 identity in 415 aa overlap). Contains PS01007 Transposases%2C Mutator family%2C signature%2C PS00435 Peroxidases proximal heme-ligand signature.;gbkey=CDS;inference=protein motif:PROSITE:PS01007;locus_tag=Rv1199c;product=Possible transposase;protein_id=CCP43955.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1341361	1342789	.	-	.	ID=id-AL123456.3:1341361..1342789;Note=IS1081-2%2C len: 1429 nt. Insertion sequence IS1081.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1081-2
AL123456.3	EMBL	gene	1342942	1344219	.	+	.	ID=gene-Rv1200;Name=Rv1200;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1200
AL123456.3	EMBL	CDS	1342942	1344219	.	+	0	ID=cds-CCP43956.1;Parent=gene-Rv1200;Dbxref=EnsemblGenomes-Gn:Rv1200,EnsemblGenomes-Tr:CCP43956,GOA:O05301,InterPro:IPR004736,InterPro:IPR005828,InterPro:IPR005829,InterPro:IPR016196,InterPro:IPR020846,UniProtKB/TrEMBL:O05301,NCBI_GP:CCP43956.1;Name=CCP43956.1;Note=Rv1200%2C (MTCI364.12)%2C len: 425 aa. Probable conserved integral membrane transport protein%2C possibly member of major facilitator superfamily (MFS)%2C similar to others e.g. YHJE_ECOLI|P37643 hypothetical metabolite transport protein from Escherichia coli (440 aa)%2C FASTA scores: opt: 1047%2C E(): 0%2C (39.1%25 identity in 427 aa overlap)%3B etc. Contains PS00217 Sugar transport proteins signature 2. The transcription of this CDS seems to be activated in macrophages (see citation below).;gbkey=CDS;inference=protein motif:PROSITE:PS00217;locus_tag=Rv1200;product=Probable conserved integral membrane transport protein;protein_id=CCP43956.1;transl_table=11
AL123456.3	EMBL	gene	1344216	1345169	.	-	.	ID=gene-Rv1201c;Name=dapD;gbkey=Gene;gene=dapD;gene_biotype=protein_coding;locus_tag=Rv1201c
AL123456.3	EMBL	CDS	1344216	1345169	.	-	0	ID=cds-CCP43957.1;Parent=gene-Rv1201c;Dbxref=EnsemblGenomes-Gn:Rv1201c,EnsemblGenomes-Tr:CCP43957,GOA:P9WP21,InterPro:IPR011004,InterPro:IPR019875,InterPro:IPR026586,PDB:3FSX,PDB:3FSY,NCBI_GP:CCP43957.1;Name=CCP43957.1;Note=Rv1201c%2C (MTCI364.13c)%2C len: 317 aa. dapD%2Ctetrahydrodipicolinate N-succinyltransferase. Highly similar to Q49948|U1756F Mycobacterium leprae (317 aa)%2CFASTA scores: opt: 1776%2C E(): 0%2C (84.9%25 identity in 317 aa overlap)%2C also Q46064 ORF3 protein from corynebacterium glutamicum (316 aa)%2C FASTA scores: opt: 864%2C E(): 0%2C (44.1%25 identity in 311 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dapD;locus_tag=Rv1201c;product=Tetrahydrodipicolinate N-succinyltransferase DapD;protein_id=CCP43957.1;transl_table=11
AL123456.3	EMBL	gene	1345260	1346324	.	+	.	ID=gene-Rv1202;Name=dapE;gbkey=Gene;gene=dapE;gene_biotype=protein_coding;locus_tag=Rv1202
AL123456.3	EMBL	CDS	1345260	1346324	.	+	0	ID=cds-CCP43958.1;Parent=gene-Rv1202;Dbxref=EnsemblGenomes-Gn:Rv1202,EnsemblGenomes-Tr:CCP43958,GOA:P9WHS9,InterPro:IPR001261,InterPro:IPR002933,InterPro:IPR010174,InterPro:IPR011650,NCBI_GP:CCP43958.1;Name=CCP43958.1;Note=Rv1202%2C (MTCI364.14)%2C len: 354 aa. Probable dapE%2Csuccinyl-diaminopimelate desuccinylase%2C similar to DAPE_CORGL|Q59284 succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum (369 aa)%2C FASTA scores: opt: 1301%2C E(): 0%2C (55.7%25 identity in 359 aa overlap)%2Chighly similar to Q49949|U1756G (400 aa)%2C FASTA scores: opt: 2045%2C E(): 0%2C (87.0%25 identity in 354 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dapE;locus_tag=Rv1202;product=Probable succinyl-diaminopimelate desuccinylase DapE;protein_id=CCP43958.1;transl_table=11
AL123456.3	EMBL	gene	1346321	1346905	.	-	.	ID=gene-Rv1203c;Name=Rv1203c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1203c
AL123456.3	EMBL	CDS	1346321	1346905	.	-	0	ID=cds-CCP43959.1;Parent=gene-Rv1203c;Dbxref=EnsemblGenomes-Gn:Rv1203c,EnsemblGenomes-Tr:CCP43959,InterPro:IPR011990,UniProtKB/TrEMBL:O05304,NCBI_GP:CCP43959.1;Name=CCP43959.1;Note=Rv1203c%2C (MTCI364.15c)%2C len: 194 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1203c;product=Hypothetical protein;protein_id=CCP43959.1;transl_table=11
AL123456.3	EMBL	gene	1346936	1348624	.	-	.	ID=gene-Rv1204c;Name=Rv1204c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1204c
AL123456.3	EMBL	CDS	1346936	1348624	.	-	0	ID=cds-CCP43960.1;Parent=gene-Rv1204c;Dbxref=EnsemblGenomes-Gn:Rv1204c,EnsemblGenomes-Tr:CCP43960,InterPro:IPR003593,InterPro:IPR027417,UniProtKB/TrEMBL:O05305,NCBI_GP:CCP43960.1;Name=CCP43960.1;Note=Rv1204c%2C (MTCI364.16c)%2C len: 562 aa. Conserved hypothetical protein%2C some similarity to Q55103 CHO-ORF2 from streptomyces SP. (642 aa)%2C FASTA scores: opt: 215%2CE(): 3.6e-06%2C (26.4%25 identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1204c;product=Conserved hypothetical protein;protein_id=CCP43960.1;transl_table=11
AL123456.3	EMBL	gene	1348719	1349282	.	+	.	ID=gene-Rv1205;Name=Rv1205;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1205
AL123456.3	EMBL	CDS	1348719	1349282	.	+	0	ID=cds-CCP43961.1;Parent=gene-Rv1205;Dbxref=EnsemblGenomes-Gn:Rv1205,EnsemblGenomes-Tr:CCP43961,InterPro:IPR005269,UniProtKB/TrEMBL:O05306,NCBI_GP:CCP43961.1;Name=CCP43961.1;Note=Rv1205%2C (MTCI364.17)%2C len: 187 aa. Conserved hypothetical protein%2C similar to Q49952 cosmid B1756 from Mycobacterium leprae (187 aa)%2C FASTA scores: opt: 865%2C E(): 0%2C (72.4%25 identity in 174 aa overlap)%2C also similar to FAS6_RHOFA|P46378 hypothetical 21.1 kDa protein in fasciation locus (ORF6) (198 aa)%2C FASTA scores: opt: 368%2CE(): 1.3e-17%2C (37.4%25 identity in 174 aa overlap). Some similarity to YJL055W Hypothetical protein in BTN1-PEP8 intergenic region from Saccharomyces cerevisiae and P48636 hypothetical protein in AZU 5'region from Pseudomonas aeruginosa. The transcription of this CDS seems to be activated specifically in host granulomas (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1205;product=Conserved hypothetical protein;protein_id=CCP43961.1;transl_table=11
AL123456.3	EMBL	gene	1349332	1351125	.	+	.	ID=gene-Rv1206;Name=fadD6;gbkey=Gene;gene=fadD6;gene_biotype=protein_coding;locus_tag=Rv1206
AL123456.3	EMBL	CDS	1349332	1351125	.	+	0	ID=cds-CCP43962.1;Parent=gene-Rv1206;Dbxref=EnsemblGenomes-Gn:Rv1206,EnsemblGenomes-Tr:CCP43962,GOA:O05307,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O05307,NCBI_GP:CCP43962.1;Name=CCP43962.1;Note=Rv1206%2C (MTCI364.18)%2C len: 597 aa. Probable fadD6%2Cfatty-acid-CoA synthetase%2C highly similar to several e.g. NP_251583.1|NC_002516 probable very-long-chain acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa)%3B Q60714 mouse fatty acid transport protein fatp (646 aa)%2C FASTA scores: opt:712%2C E(): 0%2C (36.8%25 identity in 600 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD6;inference=protein motif:PROSITE:PS00455;locus_tag=Rv1206;product=Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP43962.1;transl_table=11
AL123456.3	EMBL	gene	1351191	1352147	.	+	.	ID=gene-Rv1207;Name=folP2;gbkey=Gene;gene=folP2;gene_biotype=protein_coding;locus_tag=Rv1207
AL123456.3	EMBL	CDS	1351191	1352147	.	+	0	ID=cds-CCP43963.1;Parent=gene-Rv1207;Dbxref=EnsemblGenomes-Gn:Rv1207,EnsemblGenomes-Tr:CCP43963,GOA:P9WNC9,InterPro:IPR000489,InterPro:IPR006390,InterPro:IPR011005,PDB:2VP8,NCBI_GP:CCP43963.1;Name=CCP43963.1;Note=Rv1207%2C (MTCI364.19)%2C len: 318 aa. folP2%2CDihydropteroate synthase 2%2C similar to many e.g. DHPS_ECOLI|P26282 Escherichia coli (282 aa)%2C FASTA scores: opt: 480%2C E(): 1.9e-22%2C (34.4%25 identity in 270 aa overlap). Contains PS00792 dihydropteroate synthase signature 1%2CPS00793 dihydropteroate synthase signature 2.;gbkey=CDS;gene=folP2;inference=protein motif:PROSITE:PS00793;locus_tag=Rv1207;product=Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2);protein_id=CCP43963.1;transl_table=11
AL123456.3	EMBL	gene	1352144	1353118	.	+	.	ID=gene-Rv1208;Name=gpgS;gbkey=Gene;gene=gpgS;gene_biotype=protein_coding;locus_tag=Rv1208
AL123456.3	EMBL	CDS	1352144	1353118	.	+	0	ID=cds-CCP43964.1;Parent=gene-Rv1208;Dbxref=EnsemblGenomes-Gn:Rv1208,EnsemblGenomes-Tr:CCP43964,GOA:P9WMW9,InterPro:IPR001173,InterPro:IPR029044,PDB:3E25,PDB:3E26,PDB:4DDZ,PDB:4DE7,PDB:4DEC,NCBI_GP:CCP43964.1;Name=CCP43964.1;Note=Rv1208%2C (MTCI364.20)%2C len: 324 aa. Probable gpgS%2Cglucosyl-3-phosphoglycerate synthase (See Empadinhas et al.%2C 2008)%2C similar to Q49955|U1756L Mycobacterium leprae (318 aa)%2C FASTA scores%2C opt: 1621%2C E(): 0%2C (80.5%25 identity in 318 aa overlap). Belongs to retaining glycosyltransferase family 81.;gbkey=CDS;gene=gpgS;locus_tag=Rv1208;product=Probable glucosyl-3-phosphoglycerate synthase GpgS;protein_id=CCP43964.1;transl_table=11
AL123456.3	EMBL	gene	1353157	1353525	.	+	.	ID=gene-Rv1209;Name=Rv1209;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1209
AL123456.3	EMBL	CDS	1353157	1353525	.	+	0	ID=cds-CCP43965.1;Parent=gene-Rv1209;Dbxref=EnsemblGenomes-Gn:Rv1209,EnsemblGenomes-Tr:CCP43965,GOA:O05310,InterPro:IPR019933,UniProtKB/TrEMBL:O05310,NCBI_GP:CCP43965.1;Name=CCP43965.1;Note=Rv1209%2C (MTCI364.21)%2C len: 122 aa. Conserved protein%2C containing a hydrophobic N-terminus. Similar to Q49956|U1756M hypothetical protein from Mycobacterium leprae (114 aa)%2C FASTA scores: opt: 524%2C E(): 8.9e-29%2C(78.6%25 identity in 112 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1209;product=Conserved protein;protein_id=CCP43965.1;transl_table=11
AL123456.3	EMBL	gene	1353522	1354136	.	+	.	ID=gene-Rv1210;Name=tagA;gbkey=Gene;gene=tagA;gene_biotype=protein_coding;locus_tag=Rv1210
AL123456.3	EMBL	CDS	1353522	1354136	.	+	0	ID=cds-CCP43966.1;Parent=gene-Rv1210;Dbxref=EnsemblGenomes-Gn:Rv1210,EnsemblGenomes-Tr:CCP43966,GOA:O05311,InterPro:IPR004597,InterPro:IPR005019,InterPro:IPR011257,UniProtKB/TrEMBL:O05311,NCBI_GP:CCP43966.1;Name=CCP43966.1;Note=Rv1210%2C (MTCI364.22)%2C len: 204 aa. Probable tagA%2CDNA-3-methyladenine glycosidase I (see citation below)%2Csimilar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichia coli (187 aa)%2C FASTA scores: opt: 530%2C E(): 1.3e-27%2C (44.2%25 identity in 190 aa overlap)%3B similar to Q49957 Mycobacterium leprae cosmid B1756 (192 aa)%2C FASTA scores: opt: 1042%2C E(): 0%2C (80.2%25 identity in 192 aa overlap).;gbkey=CDS;gene=tagA;locus_tag=Rv1210;product=Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I%2C constitutive) (DNA-3-methyladenine glycosidase I);protein_id=CCP43966.1;transl_table=11
AL123456.3	EMBL	gene	1354243	1354470	.	+	.	ID=gene-Rv1211;Name=Rv1211;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1211
AL123456.3	EMBL	CDS	1354243	1354470	.	+	0	ID=cds-CCP43967.1;Parent=gene-Rv1211;Dbxref=EnsemblGenomes-Gn:Rv1211,EnsemblGenomes-Tr:CCP43967,GOA:O05312,InterPro:IPR021465,UniProtKB/TrEMBL:O05312,NCBI_GP:CCP43967.1;Name=CCP43967.1;Note=Rv1211%2C (MTCI364.23)%2C len: 75 aa. Conserved protein%2Csimilar to Q49958|U1756N Mycobacterium leprae (75 aa)%2CFASTA scores: opt: 460%2C E(): 0%2C (90.7%25 identity in 75 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1211;product=Conserved protein;protein_id=CCP43967.1;transl_table=11
AL123456.3	EMBL	gene	1354498	1355661	.	-	.	ID=gene-Rv1212c;Name=glgA;gbkey=Gene;gene=glgA;gene_biotype=protein_coding;locus_tag=Rv1212c
AL123456.3	EMBL	CDS	1354498	1355661	.	-	0	ID=cds-CCP43968.1;Parent=gene-Rv1212c;Dbxref=EnsemblGenomes-Gn:Rv1212c,EnsemblGenomes-Tr:CCP43968,GOA:P9WMZ1,InterPro:IPR001296,InterPro:IPR011875,InterPro:IPR028098,NCBI_GP:CCP43968.1;Name=CCP43968.1;Note=Rv1212c%2C (MTCI364.24c)%2C len: 387 aa. Putative glgA%2Cglycosyl transferase%2C highly similar to AJ243803|SCO243803_2 Putative glycosyl transferase from Streptomyces coelicolor (387 aa)%2C FASTA scores: opt: 1344%2CE(): 0%2C (54.9%25 identity in 388 aa overlap). Also similar to MJ1607 probable hexosyltransferase from Methanococcus jannaschii (390 aa)%2C FASTA scores: opt: 445%2C E(): 7.8e-23%2C(27.9%25 identity in 401 aa overlap). The region from aa 267-355 highly similar to Q49959 cosmid B1756 from Mycobacterium leprae (91 aa)%2C FASTA scores%2C opt: 471%2C E(): 4.8e-25%2C (80.9%25 identity in 89 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein%2C Rv3032.;gbkey=CDS;gene=glgA;locus_tag=Rv1212c;product=Putative glycosyl transferase GlgA;protein_id=CCP43968.1;transl_table=11
AL123456.3	EMBL	gene	1355836	1357050	.	+	.	ID=gene-Rv1213;Name=glgC;gbkey=Gene;gene=glgC;gene_biotype=protein_coding;locus_tag=Rv1213
AL123456.3	EMBL	CDS	1355836	1357050	.	+	0	ID=cds-CCP43969.1;Parent=gene-Rv1213;Dbxref=EnsemblGenomes-Gn:Rv1213,EnsemblGenomes-Tr:CCP43969,GOA:P9WN43,InterPro:IPR005835,InterPro:IPR005836,InterPro:IPR011004,InterPro:IPR011831,InterPro:IPR023049,InterPro:IPR029044,NCBI_GP:CCP43969.1;Name=CCP43969.1;Note=Rv1213%2C (MTCI364.25)%2C len: 404 aa. glgC%2Cglucose-1-phosphate adenylyltransferase%2C similar to many e.g. GLGC_ECOLI|P00584 Escherichia coli (430 aa)%2C FASTA scores: opt: 1075%2C E(): 0%2C (40.3%25 identity in 407 aa overlap)%3B highly similar to Q49961 GLGC from Mycobacterium leprae (419 aa)%2C FASTA scores: opt: 2532%2C E(): 0%2C (92.6%25 identity in 404 aa overlap). Belongs to the bacterial and plants glucose-1-phosphate adenylyltransferase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glgC;locus_tag=Rv1213;product=Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase);protein_id=CCP43969.1;transl_table=11
AL123456.3	EMBL	gene	1357293	1357625	.	-	.	ID=gene-Rv1214c;Name=PE14;gbkey=Gene;gene=PE14;gene_biotype=protein_coding;locus_tag=Rv1214c
AL123456.3	EMBL	CDS	1357293	1357625	.	-	0	ID=cds-CCP43970.1;Parent=gene-Rv1214c;Dbxref=EnsemblGenomes-Gn:Rv1214c,EnsemblGenomes-Tr:CCP43970,InterPro:IPR000084,UniProtKB/TrEMBL:L7N6A7,NCBI_GP:CCP43970.1;Name=CCP43970.1;Note=Rv1214c%2C (MTCI364.26c)%2C len: 110 aa. PE14%2C Member of Mycobacterium tuberculosis PE family (see citation below)%2Cappears to be frameshifted but sequence appears to be correct. The 5'-end is atypical as first 9 aa appear to be missing.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE14;locus_tag=Rv1214c;product=PE family protein PE14;protein_id=CCP43970.1;transl_table=11
AL123456.3	EMBL	gene	1357759	1359444	.	-	.	ID=gene-Rv1215c;Name=Rv1215c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1215c
AL123456.3	EMBL	CDS	1357759	1359444	.	-	0	ID=cds-CCP43971.1;Parent=gene-Rv1215c;Dbxref=EnsemblGenomes-Gn:Rv1215c,EnsemblGenomes-Tr:CCP43971,GOA:O05316,InterPro:IPR000383,InterPro:IPR005674,InterPro:IPR008979,InterPro:IPR013736,InterPro:IPR029058,UniProtKB/TrEMBL:O05316,NCBI_GP:CCP43971.1;Name=CCP43971.1;Note=Rv1215c%2C (MTCI364.27c)%2C len: 561 aa. Conserved protein%2C low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa)%2C FASTA scores: opt: 257%2C E(): 1.3e-09%2C (34.1%25 identity in 185 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1215c;product=Conserved protein;protein_id=CCP43971.1;transl_table=11
AL123456.3	EMBL	gene	1359472	1360146	.	-	.	ID=gene-Rv1216c;Name=Rv1216c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1216c
AL123456.3	EMBL	CDS	1359472	1360146	.	-	0	ID=cds-CCP43972.1;Parent=gene-Rv1216c;Dbxref=EnsemblGenomes-Gn:Rv1216c,EnsemblGenomes-Tr:CCP43972,InterPro:IPR007318,UniProtKB/TrEMBL:O05317,NCBI_GP:CCP43972.1;Name=CCP43972.1;Note=Rv1216c%2C (MTCI364.28c)%2C len: 224 aa. Probable conserved integral membrane protein%2C C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa)%2C FASTA scores: opt: 311%2C E(): 3.3e-15%2C (52.2%25 identity in 113 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1216c;product=Probable conserved integral membrane protein;protein_id=CCP43972.1;transl_table=11
AL123456.3	EMBL	gene	1360155	1361801	.	-	.	ID=gene-Rv1217c;Name=Rv1217c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1217c
AL123456.3	EMBL	CDS	1360155	1361801	.	-	0	ID=cds-CCP43973.1;Parent=gene-Rv1217c;Dbxref=EnsemblGenomes-Gn:Rv1217c,EnsemblGenomes-Tr:CCP43973,UniProtKB/TrEMBL:O05318,NCBI_GP:CCP43973.1;Name=CCP43973.1;Note=Rv1217c%2C (MTCI364.29c)%2C len: 548 aa. Probable tetronasin-transport integral membrane ABC transporter (see citation below)%2C similar to many e.g. AL049754|SCH10_12 probable ABC-type transport system membrane-spanning protein from Streptomyces coelicolor (539 aa)%2C FASTA scores: opt: 1309%2C E(): 0%2C (40.9%25 identity in 550 aa overlap)%3B Q54407|X73633 TnrB3 protein from Streptomyces longisporoflavus (337 aa)%2C FASTA scores: opt: 692%2C E(): 0%2C(39.5%25 identity in 324 aa overlap)%3B etc. Also has regions similar to Mycobacterium leprae proteins Q49964|U1756Q (109 aa)%2C FASTA scores: opt: 431%2C E(): 3.1e-20%2C (64.8%25 identity in 105 aa overlap) and Q49965|U1756R (82 aa)%2C FASTA scores: opt:154%2C E(): 0.0028%2C (61.0%25 identity in 41 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1217c;product=Probable tetronasin-transport integral membrane protein ABC transporter;protein_id=CCP43973.1;transl_table=11
AL123456.3	EMBL	gene	1361798	1362733	.	-	.	ID=gene-Rv1218c;Name=Rv1218c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1218c
AL123456.3	EMBL	CDS	1361798	1362733	.	-	0	ID=cds-CCP43974.1;Parent=gene-Rv1218c;Dbxref=EnsemblGenomes-Gn:Rv1218c,EnsemblGenomes-Tr:CCP43974,GOA:O86311,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O86311,NCBI_GP:CCP43974.1;Name=CCP43974.1;Note=Rv1218c%2C (MTCI61.01c)%2C len: 311 aa. Probable tetronasin-transport ATP-binding protein ABC transporter (see citation below)%2C similar to many e.g. Q54406|X73633|TNRB2 TNRB2 protein from Streptomyces longisporoflavus (300 aa)%2C FASTA scores: opt: 1133%2C E(): 0%2C(60.8%25 identity in 291 aa overlap)%3B etc. Also similar to others in Mycobacterium tuberculosis e.g. MTCY19H9.04 (30.0%25 identity in 297 aa overlap)%3B etc. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1218c;product=Probable tetronasin-transport ATP-binding protein ABC transporter;protein_id=CCP43974.1;transl_table=11
AL123456.3	EMBL	gene	1362723	1363361	.	-	.	ID=gene-Rv1219c;Name=Rv1219c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1219c
AL123456.3	EMBL	CDS	1362723	1363361	.	-	0	ID=cds-CCP43975.1;Parent=gene-Rv1219c;Dbxref=EnsemblGenomes-Gn:Rv1219c,EnsemblGenomes-Tr:CCP43975,GOA:O86312,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,PDB:4NN1,UniProtKB/TrEMBL:O86312,NCBI_GP:CCP43975.1;Name=CCP43975.1;Note=Rv1219c%2C (MTCI61.02c)%2C len: 212 aa. Probable transcriptional regulatory protein%2C some similarity in N-terminus to YBIH_ECOLI|P41037 hypothetical transcriptional regulator from Escherichia coli (103 aa)%2CFASTA scores: opt: 143%2C E(): 8.9e-06%2C (39.7%25 identity in 63 aa overlap)%3B Helix turn helix motif from aa 28-49.;gbkey=CDS;locus_tag=Rv1219c;product=Probable transcriptional regulatory protein;protein_id=CCP43975.1;transl_table=11
AL123456.3	EMBL	gene	1363503	1364150	.	-	.	ID=gene-Rv1220c;Name=Rv1220c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1220c
AL123456.3	EMBL	CDS	1363503	1364150	.	-	0	ID=cds-CCP43976.1;Parent=gene-Rv1220c;Dbxref=EnsemblGenomes-Gn:Rv1220c,EnsemblGenomes-Tr:CCP43976,GOA:P9WJZ7,InterPro:IPR002935,InterPro:IPR029063,NCBI_GP:CCP43976.1;Name=CCP43976.1;Note=Rv1220c%2C (MTCI61.03c)%2C len: 215 aa. Possible methyltransferase%2C some similarity to MDMC_STRMY|Q00719 o-methyltransferase from Streptomyces mycarofaciens (221 aa)%2C FASTA scores%3B opt: 289%2C E(): 1.3e-07%2C (30.0%25 identity in 203 aa overlap). Also similar to Mycobacterium tuberculosis methyltransferases Rv0187|MTCI28.26 (32.9%25 identity in 222 aa overlap) and Rv1703c. Start site chosen by homology%3B other possible start sites exist upstream.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1220c;product=Probable methyltransferase;protein_id=CCP43976.1;transl_table=11
AL123456.3	EMBL	gene	1364413	1365186	.	+	.	ID=gene-Rv1221;Name=sigE;gbkey=Gene;gene=sigE;gene_biotype=protein_coding;locus_tag=Rv1221
AL123456.3	EMBL	CDS	1364413	1365186	.	+	0	ID=cds-CCP43977.1;Parent=gene-Rv1221;Dbxref=EnsemblGenomes-Gn:Rv1221,EnsemblGenomes-Tr:CCP43977,GOA:P9WGG7,InterPro:IPR007627,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,NCBI_GP:CCP43977.1;Name=CCP43977.1;Note=Rv1221%2C (MTCI61.04)%2C len: 257 aa. SigE%2C alternative sigma factor of extracytoplasmic function (ECF) family (see citations below). Similar to many e.g. RPOE_HAEIN|P44790 RNA polymerase sigma-e factor from Haemophilus influenzae (189 aa)%2C FASTA scores: opt: 247%2C E(): 3.4e-06%2C (28.5%25 identity in 186 aa overlap)%3B etc. Also similar to MTCY07D11.03 rpoE from Mycobacterium tuberculosis (35.2%25 identity in 159 aa overlap). Belongs to the sigma-70 factor family%2C ECF subfamily. Three promoters and three translational start codons have been detected (See Dona et al.%2C 2008). Fourth transcriptional start point has been identified (See Pang et al.%2C 2007). Note that in Mycobacterium bovis BCG%2C the sigE gene is transcribed from two promoters%2C P1 and P2%2C and that these promoters were expressed at temperatures from 30-50 degrees Celsius.;gbkey=CDS;gene=sigE;locus_tag=Rv1221;product=Alternative RNA polymerase sigma factor SigE;protein_id=CCP43977.1;transl_table=11
AL123456.3	EMBL	gene	1365274	1365365	.	+	.	ID=gene-mpr6;Name=mpr6;gbkey=Gene;gene=mpr6;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1365274	1365365	.	+	.	ID=rna-mpr6;Parent=gene-mpr6;Note=mpr6%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~118 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr6;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	1365274	1365365	.	+	.	ID=exon-mpr6-1;Parent=rna-mpr6;Note=mpr6%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~118 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr6;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	1365344	1365808	.	+	.	ID=gene-Rv1222;Name=rseA;gbkey=Gene;gene=rseA;gene_biotype=protein_coding;locus_tag=Rv1222
AL123456.3	EMBL	CDS	1365344	1365808	.	+	0	ID=cds-CCP43978.1;Parent=gene-Rv1222;Dbxref=EnsemblGenomes-Gn:Rv1222,EnsemblGenomes-Tr:CCP43978,GOA:L0T905,NCBI_GP:CCP43978.1;Name=CCP43978.1;Note=Rv1222%2C (MTCI61.05)%2C len: 154 aa. RseA%2C anti-sigma factor (See Dona et al.%2C 2008). Identical to O06290|MTU87242 (but shorter due to different start site chosen by proximity of RBS). Equivalent to O05736|U87308|MAU87308_2 hypothetical protein from Mycobacterium avium (133 aa)%2C FASTA scores: opt: 644%2C E(): 7e-32%2C (86.2%25 identity in 109 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rseA;locus_tag=Rv1222;product=Anti-sigma factor RseA;protein_id=CCP43978.1;transl_table=11
AL123456.3	EMBL	gene	1365875	1367461	.	+	.	ID=gene-Rv1223;Name=htrA;gbkey=Gene;gene=htrA;gene_biotype=protein_coding;gene_synonym=degP;locus_tag=Rv1223
AL123456.3	EMBL	CDS	1365875	1367461	.	+	0	ID=cds-CCP43979.1;Parent=gene-Rv1223;Dbxref=EnsemblGenomes-Gn:Rv1223,EnsemblGenomes-Tr:CCP43979,GOA:O06291,InterPro:IPR001478,InterPro:IPR001940,InterPro:IPR009003,UniProtKB/TrEMBL:O06291,NCBI_GP:CCP43979.1;Name=CCP43979.1;Note=Rv1223%2C (MTCI61.06)%2C len: 528 aa. Probable htrA (alternate gene name: degP)%2C serine protease precursor (see citations below)%2C equivalent to U15180|MLU15180_31|Q49972|ML1078|HTRA possible serine protease from Mycobacterium leprae (533 aa)%2C FASTA scores: opt: 2777%2C E(): 4.1e-141%2C (81.6%25 identity in 533 aa overlap). Also similar to many others e.g. HTRA_ECOLI|P09376 protease do precursor from Escherichia coli (474 aa)%2C FASTA scores: opt: 581%2C E(): 9.1e-27%2C (36.3%25 identity in 278 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Start changed since first submission (-21 aa). Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=htrA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1223;product=Probable serine protease HtrA (DEGP protein);protein_id=CCP43979.1;transl_table=11
AL123456.3	EMBL	gene	1367463	1367858	.	+	.	ID=gene-Rv1224;Name=tatB;gbkey=Gene;gene=tatB;gene_biotype=protein_coding;locus_tag=Rv1224
AL123456.3	EMBL	CDS	1367463	1367858	.	+	0	ID=cds-CCP43980.1;Parent=gene-Rv1224;Dbxref=EnsemblGenomes-Gn:Rv1224,EnsemblGenomes-Tr:CCP43980,GOA:P9WG99,InterPro:IPR003369,InterPro:IPR003998,InterPro:IPR018448,NCBI_GP:CCP43980.1;Name=CCP43980.1;Note=Rv1224%2C (MTCI61.07)%2C len: 131 aa. Probable tatB%2Ccomponent of twin-arginine translocation protein export system (see citation below). Possible exported protein with hydrophobic stretch at N-terminus. Highly similar to Q49973|U15180 hypothetical protein U1756Y from Mycobacterium leprae (120 aa)%2C FASTA scores: opt: 601%2C E(): 0%2C (73.3%25 identity in 131 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=tatB;locus_tag=Rv1224;product=Probable protein TatB;protein_id=CCP43980.1;transl_table=11
AL123456.3	EMBL	gene	1367891	1368721	.	-	.	ID=gene-Rv1225c;Name=Rv1225c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1225c
AL123456.3	EMBL	CDS	1367891	1368721	.	-	0	ID=cds-CCP43981.1;Parent=gene-Rv1225c;Dbxref=EnsemblGenomes-Gn:Rv1225c,EnsemblGenomes-Tr:CCP43981,GOA:O33221,InterPro:IPR006357,InterPro:IPR023214,InterPro:IPR023215,UniProtKB/TrEMBL:O33221,NCBI_GP:CCP43981.1;Name=CCP43981.1;Note=Rv1225c%2C (MTCI61.08c)%2C len: 276 aa. Conserved hypothetical protein%2C some similarity to other hypothetical proteins e.g. AE001078|AE001078_2 Archaeoglobus fulgidus (265 aa)%2C FASTA scores: opt: 339%2C E(): 5.1e-15%2C (27.1%25 identity in 262 aa overlap)%2C and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa)%2C FASTA scores: opt: 167%2C E(): 6.4e-12%2C (24.8%25 identity in 258 aa overlap). Also weakly similar to Mycobacterium tuberculosis hypothetical protein Rv3400|MTCY78.28c (29.1%25 identity in 251 aa overlap).;gbkey=CDS;locus_tag=Rv1225c;product=Conserved hypothetical protein;protein_id=CCP43981.1;transl_table=11
AL123456.3	EMBL	gene	1368832	1370295	.	-	.	ID=gene-Rv1226c;Name=Rv1226c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1226c
AL123456.3	EMBL	CDS	1368832	1370295	.	-	0	ID=cds-CCP43982.1;Parent=gene-Rv1226c;Dbxref=EnsemblGenomes-Gn:Rv1226c,EnsemblGenomes-Tr:CCP43982,GOA:O33222,InterPro:IPR005182,InterPro:IPR014529,UniProtKB/TrEMBL:O33222,NCBI_GP:CCP43982.1;Name=CCP43982.1;Note=Rv1226c%2C (MTCI61.09c)%2C len: 487 aa. Probable transmembrane protein. Some similarity to AL049841|SCE9.01 Streptomyces coelicolor (436 aa)%2C FASTA scores: opt: 203%2CE(): 1.2e-05%2C (29.8%25 identity in 346 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1226c;product=Probable transmembrane protein;protein_id=CCP43982.1;transl_table=11
AL123456.3	EMBL	gene	1370292	1370825	.	-	.	ID=gene-Rv1227c;Name=Rv1227c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1227c
AL123456.3	EMBL	CDS	1370292	1370825	.	-	0	ID=cds-CCP43983.1;Parent=gene-Rv1227c;Dbxref=EnsemblGenomes-Gn:Rv1227c,EnsemblGenomes-Tr:CCP43983,GOA:O33223,InterPro:IPR005182,UniProtKB/TrEMBL:O33223,NCBI_GP:CCP43983.1;Name=CCP43983.1;Note=Rv1227c%2C (MTCI61.10c)%2C len: 177 aa. Possible transmembrane protein%2C similar to P96615 hypothetical protein ydbS from Bacillus subtilis (159 aa)%2C fasta scores: E(): 3.6e-07%2C (30.1%25 identity in 163 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1227c;product=Probable transmembrane protein;protein_id=CCP43983.1;transl_table=11
AL123456.3	EMBL	gene	1370920	1371477	.	+	.	ID=gene-Rv1228;Name=lpqX;gbkey=Gene;gene=lpqX;gene_biotype=protein_coding;locus_tag=Rv1228
AL123456.3	EMBL	CDS	1370920	1371477	.	+	0	ID=cds-CCP43984.1;Parent=gene-Rv1228;Dbxref=EnsemblGenomes-Gn:Rv1228,EnsemblGenomes-Tr:CCP43984,UniProtKB/TrEMBL:O33224,NCBI_GP:CCP43984.1;Name=CCP43984.1;Note=Rv1228%2C (MTCI61.11)%2C len: 185 aa. Probable lipoprotein LpqX. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqX;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1228;product=Probable lipoprotein LpqX;protein_id=CCP43984.1;transl_table=11
AL123456.3	EMBL	gene	1371777	1372949	.	-	.	ID=gene-Rv1229c;Name=mrp;gbkey=Gene;gene=mrp;gene_biotype=protein_coding;locus_tag=Rv1229c
AL123456.3	EMBL	CDS	1371777	1372949	.	-	0	ID=cds-CCP43985.1;Parent=gene-Rv1229c;Dbxref=EnsemblGenomes-Gn:Rv1229c,EnsemblGenomes-Tr:CCP43985,GOA:P9WJN7,InterPro:IPR000808,InterPro:IPR002744,InterPro:IPR019591,InterPro:IPR027417,NCBI_GP:CCP43985.1;Name=CCP43985.1;Note=Rv1229c%2C (MT1267%2C MTCI61.12c%2C MTV006.01c)%2C len: 390 aa. Probable Mrp protein%2C similar to others e.g. MRP_ECOLI|P21590 mrp protein from Escherichia coli (379 aa)%2C FASTA scores: E(): 0%2C (34.1%25 identity in 355 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%3B and PS01215 MRP Prosite domain. Belongs to the MRP/NBP35 family of ATP-binding proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mrp;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1229c;product=Probable Mrp-related protein Mrp;protein_id=CCP43985.1;transl_table=11
AL123456.3	EMBL	gene	1372962	1374197	.	-	.	ID=gene-Rv1230c;Name=Rv1230c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1230c
AL123456.3	EMBL	CDS	1372962	1374197	.	-	0	ID=cds-CCP43986.1;Parent=gene-Rv1230c;Dbxref=EnsemblGenomes-Gn:Rv1230c,EnsemblGenomes-Tr:CCP43986,GOA:O86313,InterPro:IPR001827,InterPro:IPR023346,UniProtKB/TrEMBL:O86313,NCBI_GP:CCP43986.1;Name=CCP43986.1;Note=Rv1230c%2C (MTV006.02c)%2C len: 411 aa. Possible membrane protein with two hydrophobic stretches near N-terminus. Some similarity to Rv1022|MTCY10G2.27c|Z92539 probable lpqU protein Mycobacterium tuberculosis (243 aa)%2CFASTA score: opt: 408%2C E(): 1e-11%2C (43.6%25 identity in 172 aa overlap). Similar to AL133423|SC4A7.37 hypothetical protein from Streptomyces coelicolor (421 aa)%2C FASTA score: opt: 679%2C E(): 5.1e-23%2C (36.4%25 identity in 398 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1230c;product=Possible membrane protein;protein_id=CCP43986.1;transl_table=11
AL123456.3	EMBL	gene	1374322	1374864	.	-	.	ID=gene-Rv1231c;Name=Rv1231c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1231c
AL123456.3	EMBL	CDS	1374322	1374864	.	-	0	ID=cds-CCP43987.1;Parent=gene-Rv1231c;Dbxref=EnsemblGenomes-Gn:Rv1231c,EnsemblGenomes-Tr:CCP43987,GOA:O86314,InterPro:IPR010406,UniProtKB/TrEMBL:O86314,NCBI_GP:CCP43987.1;Name=CCP43987.1;Note=Rv1231c%2C (MTV006.03c)%2C len: 180 aa. Probable membrane protein%2C similar to others e.g. AL390975 Streptomyces coelicolor (198 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1231c;product=Probable membrane protein;protein_id=CCP43987.1;transl_table=11
AL123456.3	EMBL	gene	1374861	1376168	.	-	.	ID=gene-Rv1232c;Name=Rv1232c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1232c
AL123456.3	EMBL	CDS	1374861	1376168	.	-	0	ID=cds-CCP43988.1;Parent=gene-Rv1232c;Dbxref=EnsemblGenomes-Gn:Rv1232c,EnsemblGenomes-Tr:CCP43988,GOA:O86315,InterPro:IPR000644,InterPro:IPR006668,InterPro:IPR011033,UniProtKB/TrEMBL:O86315,NCBI_GP:CCP43988.1;Name=CCP43988.1;Note=Rv1232c%2C (MTV006.04c)%2C len: 435 aa. Conserved protein%2C similar to other hypothetical proteins e.g. AB013374|AB013374_2 Bacillus halodurans C-125 mamX (449 aa)%2C FASTA scores: opt: 381%2C E(): 1e-16%2C (29.9%25 identity in 251 aa overlap). Some similarity in N-terminus to U15180|MLU1518033 hypothetical Mycobacterium leprae protein u1756u (329 aa)%2C FASTA scores: opt: 300%2C E(): 4.1e-12%2C(69.3%25 identity in 75 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1232c;product=Conserved protein;protein_id=CCP43988.1;transl_table=11
AL123456.3	EMBL	gene	1376230	1376826	.	-	.	ID=gene-Rv1233c;Name=Rv1233c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1233c
AL123456.3	EMBL	CDS	1376230	1376826	.	-	0	ID=cds-CCP43989.1;Parent=gene-Rv1233c;Dbxref=EnsemblGenomes-Gn:Rv1233c,EnsemblGenomes-Tr:CCP43989,InterPro:IPR025241,UniProtKB/TrEMBL:O86316,NCBI_GP:CCP43989.1;Name=CCP43989.1;Note=Rv1233c%2C (MTV006.05c)%2C len: 198 aa. Conserved hypothetical membrane protein%2C N-terminus is highly proline rich%2C C-terminus has two hydrophobic stretches. Proline-rich N-terminus has some similarity to CBPA_DICDI calcium binding protein from Dictyostelium discoideum (467 aa)%2C FASTA scores: E(): 4.8e-06%2C (35.5%25 identity in 183 aa overlap). Both sequences share multiple copies of a Tyr-Pro-Pro motif.;gbkey=CDS;locus_tag=Rv1233c;product=Conserved hypothetical membrane protein;protein_id=CCP43989.1;transl_table=11
AL123456.3	EMBL	gene	1376976	1377503	.	+	.	ID=gene-Rv1234;Name=Rv1234;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1234
AL123456.3	EMBL	CDS	1376976	1377503	.	+	0	ID=cds-CCP43990.1;Parent=gene-Rv1234;Dbxref=EnsemblGenomes-Gn:Rv1234,EnsemblGenomes-Tr:CCP43990,GOA:O50451,UniProtKB/TrEMBL:O50451,NCBI_GP:CCP43990.1;Name=CCP43990.1;Note=Rv1234%2C (MTV006.06)%2C len: 175 aa. Possible transmembrane protein with two TM helices.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1234;product=Probable transmembrane protein;protein_id=CCP43990.1;transl_table=11
AL123456.3	EMBL	gene	1377524	1378930	.	+	.	ID=gene-Rv1235;Name=lpqY;gbkey=Gene;gene=lpqY;gene_biotype=protein_coding;locus_tag=Rv1235
AL123456.3	EMBL	CDS	1377524	1378930	.	+	0	ID=cds-CCP43991.1;Parent=gene-Rv1235;Dbxref=EnsemblGenomes-Gn:Rv1235,EnsemblGenomes-Tr:CCP43991,GOA:P9WGU9,InterPro:IPR006059,NCBI_GP:CCP43991.1;Name=CCP43991.1;Note=Rv1235%2C (MTV006.07)%2C len: 468 aa. Probable lpqY%2Csugar-binding lipoprotein component of sugar transport system (see citation below)%2C equivalent to MLU1518034 protein u1756v from Mycobacterium leprae (469 aa)%2C FASTA scores: opt: 2442%2C E(): 0%2C (77.4%25 identity in 470 aa overlap). Also similar to P18815|MALE_ENTAE maltose-binding periplasmic protein from Enterobacter aerogenes (396 aa)%2CFASTA scores: opt: 193%2C E(): 2.3e-05%2C (24.2%25 identity in 297 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqY;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1235;product=Probable sugar-binding lipoprotein LpqY;protein_id=CCP43991.1;transl_table=11
AL123456.3	EMBL	gene	1378927	1379850	.	+	.	ID=gene-Rv1236;Name=sugA;gbkey=Gene;gene=sugA;gene_biotype=protein_coding;locus_tag=Rv1236
AL123456.3	EMBL	CDS	1378927	1379850	.	+	0	ID=cds-CCP43992.1;Parent=gene-Rv1236;Dbxref=EnsemblGenomes-Gn:Rv1236,EnsemblGenomes-Tr:CCP43992,GOA:P9WG03,InterPro:IPR000515,NCBI_GP:CCP43992.1;Name=CCP43992.1;Note=Rv1236%2C (MTV006.08)%2C len: 307 aa. Probable sugA%2Csugar-transport integral membrane protein ABC transporter (see citation below)%2C equivalent to U15180|MLU1518035 protein malFM from Mycobacterium leprae (310 aa)%2C FASTA scores: opt: 1566%2C E(): 0%2C (81.8%25 identity in 292 aa overlap). Also similar to numerous bacterial sugar transport system components. Also similar to Rv2316|MTCY3G12.18c from Mycobacterium tuberculosis (290 aa)%2C FASTA scores: opt: 514%2C E(): 7.3e-27%2C (33.2%25 identity in 283 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sugA;inference=protein motif:PROSITE:PS00402;locus_tag=Rv1236;product=Probable sugar-transport integral membrane protein ABC transporter SugA;protein_id=CCP43992.1;transl_table=11
AL123456.3	EMBL	gene	1379855	1380679	.	+	.	ID=gene-Rv1237;Name=sugB;gbkey=Gene;gene=sugB;gene_biotype=protein_coding;locus_tag=Rv1237
AL123456.3	EMBL	CDS	1379855	1380679	.	+	0	ID=cds-CCP43993.1;Parent=gene-Rv1237;Dbxref=EnsemblGenomes-Gn:Rv1237,EnsemblGenomes-Tr:CCP43993,GOA:P9WG01,InterPro:IPR000515,NCBI_GP:CCP43993.1;Name=CCP43993.1;Note=Rv1237%2C (MTV006.09)%2C len: 274 aa. Probable sugB%2Csugar-transport integral membrane protein ABC transporter (see citation below)%2C equivalent to U15180|MLU1518036 protein MalGM from Mycobacterium leprae (296 aa)%2C FASTA scores: opt: 1571%2C E(): 0%2C (89.8%25 identity in 274 aa overlap). Also similar to numerous bacterial sugar transport protein. Related to Rv2834c|MTCY16B7.08 from Mycobacterium tuberculosis (275 aa)%2C FASTA scores: opt: 370%2C E(): 2.4e-17%2C (26.8%25 identity in 269 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sugB;locus_tag=Rv1237;product=Probable sugar-transport integral membrane protein ABC transporter SugB;protein_id=CCP43993.1;transl_table=11
AL123456.3	EMBL	gene	1380684	1381865	.	+	.	ID=gene-Rv1238;Name=sugC;gbkey=Gene;gene=sugC;gene_biotype=protein_coding;locus_tag=Rv1238
AL123456.3	EMBL	CDS	1380684	1381865	.	+	0	ID=cds-CCP43994.1;Parent=gene-Rv1238;Dbxref=EnsemblGenomes-Gn:Rv1238,EnsemblGenomes-Tr:CCP43994,GOA:P9WQI3,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR008995,InterPro:IPR012340,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP43994.1;Name=CCP43994.1;Note=Rv1238%2C (MTV006.10)%2C len: 393 aa. Probable sugC%2Csugar-transport ATP-binding protein ABC transporter (see citation below). Highly similar to U15180 protein ugpC from Mycobacterium leprae (392 aa)%2C FASTA score: opt: 2007%2C E(): 0%2C (79.9%25 identity in 389 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sugC;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1238;product=Probable sugar-transport ATP-binding protein ABC transporter SugC;protein_id=CCP43994.1;transl_table=11
AL123456.3	EMBL	gene	1381942	1383042	.	-	.	ID=gene-Rv1239c;Name=corA;gbkey=Gene;gene=corA;gene_biotype=protein_coding;locus_tag=Rv1239c
AL123456.3	EMBL	CDS	1381942	1383042	.	-	0	ID=cds-CCP43995.1;Parent=gene-Rv1239c;Dbxref=EnsemblGenomes-Gn:Rv1239c,EnsemblGenomes-Tr:CCP43995,GOA:O50455,InterPro:IPR002523,InterPro:IPR004488,UniProtKB/TrEMBL:O50455,NCBI_GP:CCP43995.1;Name=CCP43995.1;Note=Rv1239c%2C (MTV006.11c)%2C len: 366 aa. Possible corA%2Cmagnesium and cobalt transport transmembrane protein%2Chighly similar to U15180 corA protein from Mycobacterium leprae (373 aa)%2C FASTA scores: opt: 1985%2C E(): 0%2C (79.1%25 identity in 369 aa overlap). Also similar to various CorA proteins of Gram negative bacteria e.g. P27841|CORA_ECOLI|B3816|Z5333|ECS4746 Magnesium and cobalt transport protein from Escherichia coli strains K12 and O157:H7 (316 aa)%2C FASTA scores: opt: 236%2C E(): 8e-08%2C(24.5%25 identity in 306 aa overlap)%3B etc. Seems to belong to the MIT family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=corA;locus_tag=Rv1239c;product=Possible magnesium and cobalt transport transmembrane protein CorA;protein_id=CCP43995.1;transl_table=11
AL123456.3	EMBL	gene	1383213	1384202	.	+	.	ID=gene-Rv1240;Name=mdh;gbkey=Gene;gene=mdh;gene_biotype=protein_coding;locus_tag=Rv1240
AL123456.3	EMBL	CDS	1383213	1384202	.	+	0	ID=cds-CCP43996.1;Parent=gene-Rv1240;Dbxref=EnsemblGenomes-Gn:Rv1240,EnsemblGenomes-Tr:CCP43996,GOA:P9WK13,InterPro:IPR001236,InterPro:IPR001252,InterPro:IPR001557,InterPro:IPR010945,InterPro:IPR015955,InterPro:IPR016040,InterPro:IPR022383,NCBI_GP:CCP43996.1;Name=CCP43996.1;Note=Rv1240%2C (MTV006.12)%2C len: 329 aa. Probable mdh%2CMalate dehydrogenase. Most similar to P50917|MDH_MYCLE malate dehydrogenase from Mycobacterium leprae (329 aa)%2CFASTA scores: opt: 1887%2C E(): 0%2C (89.1%25 identity in 329 aa overlap). Contains PS00068 Malate dehydrogenase active site signature. Belongs to the LDH family. MDH subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mdh;inference=protein motif:PROSITE:PS00068;locus_tag=Rv1240;product=Probable malate dehydrogenase Mdh;protein_id=CCP43996.1;transl_table=11
AL123456.3	EMBL	gene	1384278	1384538	.	+	.	ID=gene-Rv1241;Name=vapB33;gbkey=Gene;gene=vapB33;gene_biotype=protein_coding;locus_tag=Rv1241
AL123456.3	EMBL	CDS	1384278	1384538	.	+	0	ID=cds-CCP43997.1;Parent=gene-Rv1241;Dbxref=EnsemblGenomes-Gn:Rv1241,EnsemblGenomes-Tr:CCP43997,GOA:O50456,NCBI_GP:CCP43997.1;Name=CCP43997.1;Note=Rv1241%2C (MTV006.13)%2C len: 86 aa. Possible vapB33%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1242%2Csee Arcus et al. 2005. Member of family of 16 hypothetical Mycobacterium tuberculosis proteins including: Rv2871|Q10799|YS71_MYCTU hypothetical 13.2 kDa protein CY2 (124 aa)%2C FASTA scores: opt: 172%2C E(): 9.5e-06%2C (37.2%25 identity in 86 aa overlap)%3B Rv2132%2C Rv3321c%2C etc.;gbkey=CDS;gene=vapB33;locus_tag=Rv1241;product=Possible antitoxin VapB33;protein_id=CCP43997.1;transl_table=11
AL123456.3	EMBL	gene	1384535	1384966	.	+	.	ID=gene-Rv1242;Name=vapC33;gbkey=Gene;gene=vapC33;gene_biotype=protein_coding;locus_tag=Rv1242
AL123456.3	EMBL	CDS	1384535	1384966	.	+	0	ID=cds-CCP43998.1;Parent=gene-Rv1242;Dbxref=EnsemblGenomes-Gn:Rv1242,EnsemblGenomes-Tr:CCP43998,GOA:P9WF69,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP43998.1;Name=CCP43998.1;Note=Rv1242%2C (MTV006.14)%2C len: 143 aa. Possible vapC33%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1241%2Ccontains PIN domain%2C see Arcus et al. 2005. Member of family of 14 hypothetical Mycobacterium tuberculosis proteins including: Rv2872|Q10800|YS72_MYCTU (147 aa)%2CFASTA scores: opt: 226%2C E(): 2.7e-09%2C (32.1%25 identity in 137 aa overlap)%3B Rv0749%2C Rv0277c%2C Rv2530c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC33;locus_tag=Rv1242;product=Possible toxin VapC33. Contains PIN domain.;protein_id=CCP43998.1;transl_table=11
AL123456.3	EMBL	gene	1384989	1386677	.	-	.	ID=gene-Rv1243c;Name=PE_PGRS23;gbkey=Gene;gene=PE_PGRS23;gene_biotype=protein_coding;locus_tag=Rv1243c
AL123456.3	EMBL	CDS	1384989	1386677	.	-	0	ID=cds-CCP43999.1;Parent=gene-Rv1243c;Dbxref=EnsemblGenomes-Gn:Rv1243c,EnsemblGenomes-Tr:CCP43999,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FQ7,NCBI_GP:CCP43999.1;Name=CCP43999.1;Note=Rv1243c%2C (MTV006.15c)%2C len: 562 aa. PE_PGRS23%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS23;locus_tag=Rv1243c;product=PE-PGRS family protein PE_PGRS23;protein_id=CCP43999.1;transl_table=11
AL123456.3	EMBL	gene	1386857	1387717	.	+	.	ID=gene-Rv1244;Name=lpqZ;gbkey=Gene;gene=lpqZ;gene_biotype=protein_coding;locus_tag=Rv1244
AL123456.3	EMBL	CDS	1386857	1387717	.	+	0	ID=cds-CCP44000.1;Parent=gene-Rv1244;Dbxref=EnsemblGenomes-Gn:Rv1244,EnsemblGenomes-Tr:CCP44000,GOA:O50459,InterPro:IPR007210,UniProtKB/TrEMBL:O50459,NCBI_GP:CCP44000.1;Name=CCP44000.1;Note=Rv1244%2C (MTV006.16)%2C len: 286 aa. Probable lipoprotein lpqZ%2C equivalent toU15180|MLU1518042 protein u1756x from Mycobacterium leprae (228 aa)%2C FASTA scores: opt: 1039%2C E(): 0%2C (72.5%25 identity in 229 aa overlap). Similar to Mycobacterium tuberculosis hypothetical protein Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqZ;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1244;product=Probable lipoprotein LpqZ;protein_id=CCP44000.1;transl_table=11
AL123456.3	EMBL	gene	1387798	1388628	.	-	.	ID=gene-Rv1245c;Name=Rv1245c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1245c
AL123456.3	EMBL	CDS	1387798	1388628	.	-	0	ID=cds-CCP44001.1;Parent=gene-Rv1245c;Dbxref=EnsemblGenomes-Gn:Rv1245c,EnsemblGenomes-Tr:CCP44001,GOA:O50460,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:O50460,NCBI_GP:CCP44001.1;Name=CCP44001.1;Note=Rv1245c%2C (MTV006.17c)%2C len: 276 aa. Probable short-chain dehydrogenase/reductase%2C equivalent to NP_301801.1|NC_002677 short chain alcohol dehydrogenase from Mycobacterium leprae (277 aa). Also highly similar to various dehydrogenases and oxidoreductases e.g. NP_250228.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (295 aa)%3B NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3085|MTV013.06 probable short-chain type dehydrogenase/reductase (276 aa)%2CFASTA scores: opt: 368%2C E(): 1.2e-16%2C (35.3%25 identity in 224 aa overlap)%3B Rv3057c|MTCY22D7.24 putative short chain alcohol dehydrogenase/reductase (287 aa)%2C FASTA scores: opt: 471%2C E(): 1.3e-21%2C (32.4%25 identity in 281 aa overlap)%3B etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1245c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP44001.1;transl_table=11
AL123456.3	EMBL	gene	1388685	1388978	.	-	.	ID=gene-Rv1246c;Name=relE;gbkey=Gene;gene=relE;gene_biotype=protein_coding;gene_synonym=relE1;locus_tag=Rv1246c
AL123456.3	EMBL	CDS	1388685	1388978	.	-	0	ID=cds-CCP44002.1;Parent=gene-Rv1246c;Dbxref=EnsemblGenomes-Gn:Rv1246c,EnsemblGenomes-Tr:CCP44002,GOA:O50461,InterPro:IPR007712,NCBI_GP:CCP44002.1;Name=CCP44002.1;Note=Rv1246c%2C (MTV006.18c)%2C len: 97 aa. RelE%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv1247c (See Pandey and Gerdes%2C 2005)%2C highly similar to Rv2866|MTV003.12 hypothetical Mycobacterium tuberculosis protein (87 aa)%2CFASTA scores: opt: 290%2C E(): 3.9e-24%2C (54.1%25 identity in 85 aa overlap).;gbkey=CDS;gene=relE;locus_tag=Rv1246c;product=Toxin RelE;protein_id=CCP44002.1;transl_table=11
AL123456.3	EMBL	gene	1388975	1389244	.	-	.	ID=gene-Rv1247c;Name=relB;gbkey=Gene;gene=relB;gene_biotype=protein_coding;gene_synonym=relB1;locus_tag=Rv1247c
AL123456.3	EMBL	CDS	1388975	1389244	.	-	0	ID=cds-CCP44003.1;Parent=gene-Rv1247c;Dbxref=EnsemblGenomes-Gn:Rv1247c,EnsemblGenomes-Tr:CCP44003,GOA:O50462,InterPro:IPR006442,NCBI_GP:CCP44003.1;Name=CCP44003.1;Note=Rv1247c%2C (MTV006.19c)%2C len: 89 aa. RelB%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv1246c (See Pandey and Gerdes%2C 2005)%2C some similarity to hypothetical proteins including Mycobacterium tuberculosis proteins Rv2865|MTV003.11 (93 aa)%2C FASTA scores: opt: 249%2C E(): 5.4e-13%2C (44.2%25 identity in 86 aa overlap)%3B Rv0268|Z86089|P95225 (169 aa) opt: 125%2C E(): 0.0089%2C (41.8%25 identity in 55 aa overlap)%3B etc. and Escherichia coli AE000293|ECAE0002933 (92 aa)%2C FASTA scores: opt: 127%2C E(): 0.0038%2C (29.3%25 identity in 82 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=relB;locus_tag=Rv1247c;product=Antitoxin RelB;protein_id=CCP44003.1;transl_table=11
AL123456.3	EMBL	gene	1389357	1393052	.	-	.	ID=gene-Rv1248c;Name=Rv1248c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1248c
AL123456.3	EMBL	CDS	1389357	1393052	.	-	0	ID=cds-CCP44004.1;Parent=gene-Rv1248c;Dbxref=EnsemblGenomes-Gn:Rv1248c,EnsemblGenomes-Tr:CCP44004,GOA:P9WIS5,InterPro:IPR001017,InterPro:IPR001078,InterPro:IPR005475,InterPro:IPR011603,InterPro:IPR023213,InterPro:IPR029061,NCBI_GP:CCP44004.1;Name=CCP44004.1;Note=Rv1248c%2C (MTV006.20c)%2C len: 1231 aa. Multifunctional alpha-ketoglutarate metabolic enzyme%2C highly similar to D84102 Corynebacterium glutamicum (1257 aa)%2C FASTA scores: opt: 4418%2C E(): 0%2C (59.4%25 identity in 1223 aa overlap). Cofactor: thiamine diphosphate. Start changed since first submission (+17 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1248c;product=Multifunctional alpha-ketoglutarate metabolic enzyme;protein_id=CCP44004.1;transl_table=11
AL123456.3	EMBL	gene	1393194	1393982	.	-	.	ID=gene-Rv1249c;Name=Rv1249c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1249c
AL123456.3	EMBL	CDS	1393194	1393982	.	-	0	ID=cds-CCP44005.1;Parent=gene-Rv1249c;Dbxref=EnsemblGenomes-Gn:Rv1249c,EnsemblGenomes-Tr:CCP44005,GOA:O50464,UniProtKB/TrEMBL:O50464,NCBI_GP:CCP44005.1;Name=CCP44005.1;Note=Rv1249c%2C (MTV006.21c)%2C len: 262 aa. Possible membrane protein. Start uncertain. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1249c;product=Possible membrane protein;protein_id=CCP44005.1;transl_table=11
AL123456.3	EMBL	gene	1394179	1395918	.	+	.	ID=gene-Rv1250;Name=Rv1250;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1250
AL123456.3	EMBL	CDS	1394179	1395918	.	+	0	ID=cds-CCP44006.1;Parent=gene-Rv1250;Dbxref=EnsemblGenomes-Gn:Rv1250,EnsemblGenomes-Tr:CCP44006,GOA:P9WG87,InterPro:IPR004638,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP44006.1;Name=CCP44006.1;Note=Rv1250%2C (MTV006.22)%2C len: 579 aa. Probable drug-transport integral membrane protein%2C member of major facilitator superfamily (MFS)%2C highly similar to several including P39886|TCMA_STRGA tetracenomycin C resistance protein from Streptomyces glaucescens (538 aa)%2C FASTA scores: opt: 847%2C E(): 0%2C (32.9%25 identity in 517 aa overlap)%3B etc. Also similar to MTCY20B11.14c|Rv3239C from Mycobacterium tuberculosis (1048 aa)%2C FASTA scores: opt: 629%2C E(): 6.7e-13%2C (31.9%25 identity in 423 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1250;product=Probable drug-transport integral membrane protein;protein_id=CCP44006.1;transl_table=11
AL123456.3	EMBL	gene	1395821	1399240	.	-	.	ID=gene-Rv1251c;Name=Rv1251c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1251c
AL123456.3	EMBL	CDS	1395821	1399240	.	-	0	ID=cds-CCP44007.1;Parent=gene-Rv1251c;Dbxref=EnsemblGenomes-Gn:Rv1251c,EnsemblGenomes-Tr:CCP44007,InterPro:IPR003593,InterPro:IPR019993,InterPro:IPR027417,UniProtKB/TrEMBL:O50466,NCBI_GP:CCP44007.1;Name=CCP44007.1;Note=Rv1251c%2C (MTV006.23c)%2C len: 1139 aa. Conserved hypothetical protein%2C showing some similarity in C-terminal region with other proteins from eukaryotes and bacteria e.g. NP_142121.1 hypothetical protein from Pyrococcus horikoshii (1188 aa)%3B and some similarity to GTP-binding proteins e.g. P23249|MV10_MOUSE putative GTP-binding protein (1004 aa)%2C FASTA scores: opt: 228%2C E(): 1.7e-06%2C(27.7%25 identity in 560 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1251c;product=Conserved hypothetical protein;protein_id=CCP44007.1;transl_table=11
AL123456.3	EMBL	gene	1399296	1399904	.	-	.	ID=gene-Rv1252c;Name=lprE;gbkey=Gene;gene=lprE;gene_biotype=protein_coding;locus_tag=Rv1252c
AL123456.3	EMBL	CDS	1399296	1399904	.	-	0	ID=cds-CCP44008.1;Parent=gene-Rv1252c;Dbxref=EnsemblGenomes-Gn:Rv1252c,EnsemblGenomes-Tr:CCP44008,GOA:P9WK49,InterPro:IPR025971,NCBI_GP:CCP44008.1;Name=CCP44008.1;Note=Rv1252c%2C (MTCY50.30)%2C len: 202 aa. Probable lipoprotein lprE%2C some similarity to Mycobacterium tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa)%2C FASTA scores: E(): 7e-05%2C (29.5%25 identity in 200 aa overlap). Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprE;locus_tag=Rv1252c;product=Probable lipoprotein LprE;protein_id=CCP44008.1;transl_table=11
AL123456.3	EMBL	gene	1399970	1401661	.	+	.	ID=gene-Rv1253;Name=deaD;gbkey=Gene;gene=deaD;gene_biotype=protein_coding;locus_tag=Rv1253
AL123456.3	EMBL	CDS	1399970	1401661	.	+	0	ID=cds-CCP44009.1;Parent=gene-Rv1253;Dbxref=EnsemblGenomes-Gn:Rv1253,EnsemblGenomes-Tr:CCP44009,GOA:P9WH05,InterPro:IPR000629,InterPro:IPR001650,InterPro:IPR005580,InterPro:IPR011545,InterPro:IPR014001,InterPro:IPR014014,InterPro:IPR027417,InterPro:IPR028618,NCBI_GP:CCP44009.1;Name=CCP44009.1;Note=Rv1253%2C (MTCY50.29c)%2C len: 563 aa. Probable deaD%2CCold-shock dead-box protein A homolog%2C similar to many e.g. DEAD_ECOLI|P23304 Escherichia coli (646 aa)%2C FASTA scores: opt: 1490%2C E(): 0%2C (46.7%25 identity in 578 aa overlap)%3B similar to Mycobacterium tuberculosis Rv3211. Contains PS00017 ATP/GTP-binding site motif A%2C PS00039 dead-box subfamily ATP-dependent helicases signature. Belongs to the dead box family helicase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=deaD;inference=protein motif:PROSITE:PS00039;locus_tag=Rv1253;product=Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog);protein_id=CCP44009.1;transl_table=11
AL123456.3	EMBL	gene	1401658	1402809	.	+	.	ID=gene-Rv1254;Name=Rv1254;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1254
AL123456.3	EMBL	CDS	1401658	1402809	.	+	0	ID=cds-CCP44010.1;Parent=gene-Rv1254;Dbxref=EnsemblGenomes-Gn:Rv1254,EnsemblGenomes-Tr:CCP44010,GOA:Q11064,InterPro:IPR002656,UniProtKB/TrEMBL:Q11064,NCBI_GP:CCP44010.1;Name=CCP44010.1;Note=Rv1254%2C (MTCY50.28c)%2C len: 383 aa. Probable Acyltransferase%2C similar to G927228 midecamycin 4-0-propionyl transferase (fragment) (388 aa)%2C FASTA scores%2C opt: 305%2C E(): 5.6e-14%2C (28.4%25 identity in 377 aa overlap). Also similar to other Mycobacterium tuberculosis acyltransferases e.g. Rv0111%2C Rv0228%2C etc. Contains PS00881 Protein splicing signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00881;locus_tag=Rv1254;product=Probable acyltransferase;protein_id=CCP44010.1;transl_table=11
AL123456.3	EMBL	gene	1402778	1403386	.	-	.	ID=gene-Rv1255c;Name=Rv1255c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1255c
AL123456.3	EMBL	CDS	1402778	1403386	.	-	0	ID=cds-CCP44011.1;Parent=gene-Rv1255c;Dbxref=EnsemblGenomes-Gn:Rv1255c,EnsemblGenomes-Tr:CCP44011,GOA:P9WMD5,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,NCBI_GP:CCP44011.1;Name=CCP44011.1;Note=Rv1255c%2C (MTCY50.27)%2C len: 202 aa. Possible regulatory protein%2C similar to others e.g. ACRR_ECOLI|P34000 potential acrab operon repressor from E. coli (215 aa)%2C FASTA scores: opt: 128%2C E(): 0.25%2C (42.1%25 identity in 57 aa overlap). Helix turn helix motif present at aa 36-57 (+5.48 SD).;gbkey=CDS;locus_tag=Rv1255c;product=Probable transcriptional regulatory protein;protein_id=CCP44011.1;transl_table=11
AL123456.3	EMBL	gene	1403386	1404603	.	-	.	ID=gene-Rv1256c;Name=cyp130;gbkey=Gene;gene=cyp130;gene_biotype=protein_coding;locus_tag=Rv1256c
AL123456.3	EMBL	CDS	1403386	1404603	.	-	0	ID=cds-CCP44012.1;Parent=gene-Rv1256c;Dbxref=EnsemblGenomes-Gn:Rv1256c,EnsemblGenomes-Tr:CCP44012,GOA:P9WPN5,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,PDB:2UUQ,PDB:2UVN,PDB:2WGY,PDB:2WH8,PDB:2WHF,NCBI_GP:CCP44012.1;Name=CCP44012.1;Note=Rv1256c%2C (MT1295%2C MTCY50.26)%2C len: 405 aa. Probable cyp130%2C cytochrome P450%2C similar to other cytochromes P-450 e.g. S51594 cytochrome P450 mycG from Micromonospora griseorubida (397 aa)%3B T36526 probable cytochrome P450 hydroxylase from Streptomyces coelicolor (411 aa)%3B CPXK_SACER|P33271|107B1 cytochrome P450 from Saccharopolyspora erythraea (405 aa)%2C FASTA scores: opt: 639%2C E(): 2.7e-33%2C (33.2%25 identity in 391 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c|MTCY369.11c cytochrome P450 (402 aa)%3B etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;gbkey=CDS;gene=cyp130;inference=protein motif:PROSITE:PS00086;locus_tag=Rv1256c;product=Probable cytochrome P450 130 Cyp130;protein_id=CCP44012.1;transl_table=11
AL123456.3	EMBL	gene	1404717	1406084	.	-	.	ID=gene-Rv1257c;Name=Rv1257c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1257c
AL123456.3	EMBL	CDS	1404717	1406084	.	-	0	ID=cds-CCP44013.1;Parent=gene-Rv1257c;Dbxref=EnsemblGenomes-Gn:Rv1257c,EnsemblGenomes-Tr:CCP44013,GOA:Q11061,InterPro:IPR004113,InterPro:IPR006094,InterPro:IPR016164,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,InterPro:IPR016171,UniProtKB/TrEMBL:Q11061,NCBI_GP:CCP44013.1;Name=CCP44013.1;Note=Rv1257c%2C (MTCY50.25)%2C len: 455 aa. Probable oxidoreductase%2C similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa)%2C FASTA scores: E(): 0%2C (38.9%25 identity in 458 aa overlap). Similar to Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1257c;product=Probable oxidoreductase;protein_id=CCP44013.1;transl_table=11
AL123456.3	EMBL	gene	1406081	1407340	.	-	.	ID=gene-Rv1258c;Name=Rv1258c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1258c
AL123456.3	EMBL	CDS	1406081	1407340	.	-	0	ID=cds-CCP44014.1;Parent=gene-Rv1258c;Dbxref=EnsemblGenomes-Gn:Rv1258c,EnsemblGenomes-Tr:CCP44014,GOA:P9WJX9,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP44014.1;Name=CCP44014.1;Note=Rv1258c%2C MTCY50.24%2C len: 419 aa. Probable conserved integral membrane transport (efflux) protein%2C possibly member of major facilitator superfamily (MFS)%2C highly similar to O32859|tap protein multidrug-resistance efflux pump from Mycobacterium fortuitum (409 aa)%2C FASTA scores: E(): 0%2C (68.4%25 identity in 408 aa overlap). Contains PS00216 Sugar transport proteins signature 1.;gbkey=CDS;inference=protein motif:PROSITE:PS00216;locus_tag=Rv1258c;product=Probable conserved integral membrane transport protein;protein_id=CCP44014.1;transl_table=11
AL123456.3	EMBL	gene	1407339	1408238	.	+	.	ID=gene-Rv1259;Name=udgB;gbkey=Gene;gene=udgB;gene_biotype=protein_coding;locus_tag=Rv1259
AL123456.3	EMBL	CDS	1407339	1408238	.	+	0	ID=cds-CCP44015.1;Parent=gene-Rv1259;Dbxref=EnsemblGenomes-Gn:Rv1259,EnsemblGenomes-Tr:CCP44015,GOA:P9WM53,InterPro:IPR005122,NCBI_GP:CCP44015.1;Name=CCP44015.1;Note=Rv1259%2C (MTCY50.23c)%2C len: 299 aa. Probable udgB%2Curacil DNA glycosylase. Similar to AL109732|SC7H2.04 hypothetical protein from Streptomyces coelicolor (237 aa)%2CFASTA scores: opt: 870%2C E(): 0%2C (57.1%25 identity in 231 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=udgB;locus_tag=Rv1259;product=Probable uracil DNA glycosylase%2C UdgB;protein_id=CCP44015.1;transl_table=11
AL123456.3	EMBL	gene	1408240	1409358	.	+	.	ID=gene-Rv1260;Name=Rv1260;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1260
AL123456.3	EMBL	CDS	1408240	1409358	.	+	0	ID=cds-CCP44016.1;Parent=gene-Rv1260;Dbxref=EnsemblGenomes-Gn:Rv1260,EnsemblGenomes-Tr:CCP44016,GOA:P9WM51,InterPro:IPR002938,InterPro:IPR003042,NCBI_GP:CCP44016.1;Name=CCP44016.1;Note=Rv1260%2C (MTCY50.22c)%2C len: 372 aa. Probable oxidoreductase%2C highly similar to E1245747|AL021411 putative oxidoreductase SC7H1.18 from Streptomyces coelicolor (397 aa)%2C FASTA scores: E(): 1.4e-29%2C (45.9%25 identity in 355 aa overlap)%3B also some similarity to G912582 FAD binding protein homologue from Pseudomonas aeruginosa (286 aa)%2C FASTA scores: opt: 245%2C E(): 2e-09%2C(27.5%25 identity in 251 aa overlap)%3B PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537 aa)%2C FASTA scores: opt: 219%2C E(): 1.7e-07%2C (23.3%25 identity in 360 aa overlap)%3B TETX_BACFR|Q01911 tetracycline resistance protein (388 aa)%2CFASTA scores: opt: 183%2C E(): 3e-05%2C (22.8%25 identity in 373 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0575c and Rv1751.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1260;product=Probable oxidoreductase;protein_id=CCP44016.1;transl_table=11
AL123456.3	EMBL	gene	1409484	1409933	.	-	.	ID=gene-Rv1261c;Name=Rv1261c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1261c
AL123456.3	EMBL	CDS	1409484	1409933	.	-	0	ID=cds-CCP44017.1;Parent=gene-Rv1261c;Dbxref=EnsemblGenomes-Gn:Rv1261c,EnsemblGenomes-Tr:CCP44017,GOA:P9WP13,InterPro:IPR004378,NCBI_GP:CCP44017.1;Name=CCP44017.1;Note=Rv1261c%2C (MTCY50.21)%2C len: 149 aa. Conserved protein%2C similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1558|MTCY48.07c (39.2%25 identity in 125 aa overlap)%3B Rv3547 and Rv3178.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1261c;product=Conserved protein;protein_id=CCP44017.1;transl_table=11
AL123456.3	EMBL	gene	1409938	1410372	.	-	.	ID=gene-Rv1262c;Name=Rv1262c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1262c
AL123456.3	EMBL	CDS	1409938	1410372	.	-	0	ID=cds-CCP44018.1;Parent=gene-Rv1262c;Dbxref=EnsemblGenomes-Gn:Rv1262c,EnsemblGenomes-Tr:CCP44018,GOA:P9WML1,InterPro:IPR001310,InterPro:IPR011146,InterPro:IPR019808,NCBI_GP:CCP44018.1;Name=CCP44018.1;Note=Rv1262c%2C (MTCY50.20)%2C len: 144 aa. Hypothetical hit-like protein%2C similar to Q04344|HIT_YEAST hit1 protein (orf u) (144 aa)%2C FASTA scores: opt: 306%2C E(): 3e-14%2C (35.9 %25 identity in 142 aa overlap)%3B also similar to YHIT_MYCGE|P47378 hypothetical 15.6 kDa protein (141 aa)%2CFASTA scores: opt: 250%2C E(): 1.6e-10%2C (35.5%25 identity in 107 aa overlap)%3B and YHIT_MYCLE|P49774 hypothetical 17.0 kDa protein hit-like (155 aa)%2C FASTA scores: opt: 196%2C E(): 7e-07%2C (30.6%25 identity in 144 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. Rv2613c%2CRv0759c. Contains PS00892 hit family signature. Belongs to the hit family.;gbkey=CDS;inference=protein motif:PROSITE:PS00892;locus_tag=Rv1262c;product=Hypothetical hit-like protein;protein_id=CCP44018.1;transl_table=11
AL123456.3	EMBL	gene	1410431	1411819	.	+	.	ID=gene-Rv1263;Name=amiB2;gbkey=Gene;gene=amiB2;gene_biotype=protein_coding;locus_tag=Rv1263
AL123456.3	EMBL	CDS	1410431	1411819	.	+	0	ID=cds-CCP44019.1;Parent=gene-Rv1263;Dbxref=EnsemblGenomes-Gn:Rv1263,EnsemblGenomes-Tr:CCP44019,GOA:P9WQ97,InterPro:IPR000120,InterPro:IPR020556,InterPro:IPR023631,NCBI_GP:CCP44019.1;Name=CCP44019.1;Note=Rv1263%2C (MTCY50.19c)%2C len: 462 aa. Probable amiB2%2Camidase. Similar to G1001278 hypothetical 54.3 kDa protein (506 aa)%2C FASTA scores: opt: 767%2C E(): 7.6e-40%2C (32.8%25 identity in 461 aa overlap)%2C also similar to G580673 rhodococcus enantiose lective amidase gene (462 aa)%2C FASTA scores%2C opt: 668%2C E(): 7.4e-34%2C (33.5%25 identity in 484 aa overlap) also to NYLA_PSES8|P13398 6-aminohexanoate-cyclic-dimer hydrolase (492 aa)%2C FASTA scores opt: 543%2C E(): 3.1e-26%2C (33.5%25 identity in 493 aa overlap). Also similar to MTCY274.19c (33.5%25 identity in 427 aa overlap). Similar to other putative amidases in M. tuberculosis%3B Rv2363%2C Rv2888c%2C etc. Contains PS00017 ATP/GTP-binding site motif A. Belongs to the amidase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=amiB2;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1263;product=Probable amidase AmiB2 (aminohydrolase);protein_id=CCP44019.1;transl_table=11
AL123456.3	EMBL	gene	1411894	1413087	.	+	.	ID=gene-Rv1264;Name=Rv1264;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1264
AL123456.3	EMBL	CDS	1411894	1413087	.	+	0	ID=cds-CCP44020.1;Parent=gene-Rv1264;Dbxref=EnsemblGenomes-Gn:Rv1264,EnsemblGenomes-Tr:CCP44020,GOA:P9WMU9,InterPro:IPR001054,InterPro:IPR029787,PDB:1Y10,PDB:1Y11,PDB:2EV1,PDB:2EV2,PDB:2EV3,PDB:2EV4,NCBI_GP:CCP44020.1;Name=CCP44020.1;Note=Rv1264%2C (MTCY50.18c)%2C len: 397 aa. Adenylate cyclase (function proven experimentally: see Linder et al.%2C 2002)%2Cshowing some similarity to other adenylate cyclases e.g. CYAA_BRELI|P27580 (403 aa)%2C FASTA scores%2C opt: 270%2C E(): 1.3e-10%2C (29.3%25 identity in 317 aa overlap)%3B etc. Similar to other putative cyclases in M. tuberculosis e.g. Rv2212%2CRv1647. The C terminus seems to code for a catalytic domain belonging to a subfamily of adenylyl cyclase isozymes (mostly found in Gram-positive bacteria). The N terminus seems to be a potential novel regulator of adenylyl cyclase activity (autoinhibitory domain). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1264;product=Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase);protein_id=CCP44020.1;transl_table=11
AL123456.3	EMBL	gene	1413094	1413224	.	-	.	ID=gene-mcr11;Name=mcr11;gbkey=Gene;gene=mcr11;gene_biotype=ncRNA;gene_synonym=MTS0997
AL123456.3	EMBL	ncRNA	1413094	1413224	.	-	.	ID=rna-mcr11;Parent=gene-mcr11;Note=mcr11%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by RLM-RACE in M. tuberculosis H37Rv%2C 3'-end not mapped (See Arnvig et al.%2C 2011).;gbkey=ncRNA;gene=mcr11;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1413094	1413224	.	-	.	ID=exon-mcr11-1;Parent=rna-mcr11;Note=mcr11%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by RLM-RACE in M. tuberculosis H37Rv%2C 3'-end not mapped (See Arnvig et al.%2C 2011).;gbkey=ncRNA;gene=mcr11;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1413260	1413940	.	+	.	ID=gene-Rv1265;Name=Rv1265;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1265
AL123456.3	EMBL	CDS	1413260	1413940	.	+	0	ID=cds-CCP44021.1;Parent=gene-Rv1265;Dbxref=EnsemblGenomes-Gn:Rv1265,EnsemblGenomes-Tr:CCP44021,GOA:P9WM49,NCBI_GP:CCP44021.1;Name=CCP44021.1;Note=Rv1265%2C (MTCY50.17c)%2C len: 226 aa. Unknown protein (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1265;product=Unknown protein;protein_id=CCP44021.1;transl_table=11
AL123456.3	EMBL	gene	1413960	1415840	.	-	.	ID=gene-Rv1266c;Name=pknH;gbkey=Gene;gene=pknH;gene_biotype=protein_coding;locus_tag=Rv1266c
AL123456.3	EMBL	CDS	1413960	1415840	.	-	0	ID=cds-CCP44022.1;Parent=gene-Rv1266c;Dbxref=EnsemblGenomes-Gn:Rv1266c,EnsemblGenomes-Tr:CCP44022,GOA:P9WI71,InterPro:IPR000719,InterPro:IPR008271,InterPro:IPR011009,InterPro:IPR017441,InterPro:IPR026954,PDB:4ESQ,NCBI_GP:CCP44022.1;Name=CCP44022.1;Note=Rv1266c%2C (MTCY50.16)%2C len: 626 aa. Probable pknH%2Ctransmembrane serine/threonine-protein kinase (see citation below)%2C similar to many e.g. PKN1_MYXXA|P33973 pkn1 (693 aa)%2C FASTA scores: opt: 611%2C E(): 1.4e- 14%2C (29.7%25 identity in 492 aa overlap)%3B etc. Contains PS00107 Protein kinases ATP-binding region signature%3B PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknH;inference=protein motif:PROSITE:PS00108;locus_tag=Rv1266c;product=Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H);protein_id=CCP44022.1;transl_table=11
AL123456.3	EMBL	gene	1416181	1417347	.	-	.	ID=gene-Rv1267c;Name=embR;gbkey=Gene;gene=embR;gene_biotype=protein_coding;locus_tag=Rv1267c
AL123456.3	EMBL	CDS	1416181	1417347	.	-	0	ID=cds-CCP44023.1;Parent=gene-Rv1267c;Dbxref=EnsemblGenomes-Gn:Rv1267c,EnsemblGenomes-Tr:CCP44023,GOA:P9WGJ9,InterPro:IPR000253,InterPro:IPR001867,InterPro:IPR005158,InterPro:IPR008984,InterPro:IPR011991,InterPro:IPR016032,PDB:2FEZ,PDB:2FF4,NCBI_GP:CCP44023.1;Name=CCP44023.1;Note=Rv1267c%2C (MT1305%2C MTCY50.15)%2C len: 388 aa. Probable embR%2C regulatory protein (see citation below)%2C similar to many e.g. AFSR_STRCO|P25941 regulatory protein AfsR from Streptomyces coelicolor (993 aa)%2C FASTA scores: opt: 489%2CE(): 1e-25%2C (33.5%25 identity in 361 aa overlap)%3B etc. Belongs to the AFSR/DNRI/REDD family of regulators. Phosphorylated in vitro by PknJ|Rv2088 (See Jang et al.%2C2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=embR;locus_tag=Rv1267c;product=Probable transcriptional regulatory protein EmbR;protein_id=CCP44023.1;transl_table=11
AL123456.3	EMBL	gene	1417658	1418356	.	-	.	ID=gene-Rv1268c;Name=Rv1268c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1268c
AL123456.3	EMBL	CDS	1417658	1418356	.	-	0	ID=cds-CCP44024.1;Parent=gene-Rv1268c;Dbxref=EnsemblGenomes-Gn:Rv1268c,EnsemblGenomes-Tr:CCP44024,InterPro:IPR025660,NCBI_GP:CCP44024.1;Name=CCP44024.1;Note=Rv1268c%2C (MTCY50.14)%2C len: 232 aa. Hypothetical unknown protein%2C probably secreted protein : contains possible signal peptide sequence (score 7.9 at residue 28). Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;locus_tag=Rv1268c;product=Hypothetical protein;protein_id=CCP44024.1;transl_table=11
AL123456.3	EMBL	gene	1418579	1418953	.	-	.	ID=gene-Rv1269c;Name=Rv1269c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1269c
AL123456.3	EMBL	CDS	1418579	1418953	.	-	0	ID=cds-CCP44025.1;Parent=gene-Rv1269c;Dbxref=EnsemblGenomes-Gn:Rv1269c,EnsemblGenomes-Tr:CCP44025,GOA:P9WM45,InterPro:IPR006311,InterPro:IPR025240,NCBI_GP:CCP44025.1;Name=CCP44025.1;Note=Rv1269c%2C (MTCY50.13)%2C len: 124 aa. Conserved probable exported protein with putative N-terminal signal sequence. Similar to Mycobacterium tuberculosis protein Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30 (137 aa)%2C FASTA scores: E(): 9e-21%2C (41.6%25 identity in 137 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1269c;product=Conserved probable secreted protein;protein_id=CCP44025.1;transl_table=11
AL123456.3	EMBL	gene	1419014	1419748	.	-	.	ID=gene-Rv1270c;Name=lprA;gbkey=Gene;gene=lprA;gene_biotype=protein_coding;locus_tag=Rv1270c
AL123456.3	EMBL	CDS	1419014	1419748	.	-	0	ID=cds-CCP44026.1;Parent=gene-Rv1270c;Dbxref=EnsemblGenomes-Gn:Rv1270c,EnsemblGenomes-Tr:CCP44026,GOA:P9WK55,InterPro:IPR009830,InterPro:IPR029046,NCBI_GP:CCP44026.1;Name=CCP44026.1;Note=Rv1270c%2C (MTCY50.12)%2C len: 244 aa. Possible lprA%2Clipoprotein. Similar to O32852|AJ000500 lipoprotein from Mycobacterium bovis (236 aa)%2C fasta scores: E(): 5.2e-23%2C(35.1%25 identity in 245 aa overlap). Similar to M. tuberculosis lipoproteins: Rv1368%2C Rv1411c%2C Rv2945c. Contains probable N-terminal signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprA;locus_tag=Rv1270c;product=Possible lipoprotein LprA;protein_id=CCP44026.1;transl_table=11
AL123456.3	EMBL	gene	1419961	1420302	.	-	.	ID=gene-Rv1271c;Name=Rv1271c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1271c
AL123456.3	EMBL	CDS	1419961	1420302	.	-	0	ID=cds-CCP44027.1;Parent=gene-Rv1271c;Dbxref=EnsemblGenomes-Gn:Rv1271c,EnsemblGenomes-Tr:CCP44027,InterPro:IPR007969,NCBI_GP:CCP44027.1;Name=CCP44027.1;Note=Rv1271c%2C (MTCY50.11)%2C len: 113 aa. Conserved hypothetical exported protein with potential N-terminal signal sequence. Similar to Mycobacterium tuberculosis hypothetical proteins Rv1804c%2C Rv1810%2C Rv0622%2C etc.;gbkey=CDS;locus_tag=Rv1271c;product=Conserved hypothetical secreted protein;protein_id=CCP44027.1;transl_table=11
AL123456.3	EMBL	gene	1420410	1422305	.	-	.	ID=gene-Rv1272c;Name=Rv1272c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1272c
AL123456.3	EMBL	CDS	1420410	1422305	.	-	0	ID=cds-CCP44028.1;Parent=gene-Rv1272c;Dbxref=EnsemblGenomes-Gn:Rv1272c,EnsemblGenomes-Tr:CCP44028,GOA:P9WQJ3,InterPro:IPR001140,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR011527,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP44028.1;Name=CCP44028.1;Note=Rv1272c%2C (MTCY50.10)%2C len: 631 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below)%2C similar to e.g. Y015_MYCGE|P47261 hypothetical ABC transporter mg015m from Mycoplasma genitalium (589 aa)%2C FASTA scores: opt: 1054%2CE(): 0%2C (34.3%25 identity in 522 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%3B and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters)%2CMSBA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1272c;product=Probable drugs-transport transmembrane ATP-binding protein ABC transporter;protein_id=CCP44028.1;transl_table=11
AL123456.3	EMBL	gene	1422302	1424050	.	-	.	ID=gene-Rv1273c;Name=Rv1273c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1273c
AL123456.3	EMBL	CDS	1422302	1424050	.	-	0	ID=cds-CCP44029.1;Parent=gene-Rv1273c;Dbxref=EnsemblGenomes-Gn:Rv1273c,EnsemblGenomes-Tr:CCP44029,GOA:P9WQJ1,InterPro:IPR001140,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR011527,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP44029.1;Name=CCP44029.1;Note=Rv1273c%2C (MTCY50.09)%2C len: 582 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below)%2C similar to e.g. YWJA_BACSU|P45861 hypothetical abc transporter from B. subtilis (575 aa)%2C FASTA scores: opt: 810%2C E(): 0%2C (27.0%25 identity in 578 aa overlap)%3B etc. Contains PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site%3B 2 x PS00211 ABC transporters family signature%3B and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters)%2CMSBA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1273c;product=Probable drugs-transport transmembrane ATP-binding protein ABC transporter;protein_id=CCP44029.1;transl_table=11
AL123456.3	EMBL	gene	1424197	1424754	.	+	.	ID=gene-Rv1274;Name=lprB;gbkey=Gene;gene=lprB;gene_biotype=protein_coding;locus_tag=Rv1274
AL123456.3	EMBL	CDS	1424197	1424754	.	+	0	ID=cds-CCP44030.1;Parent=gene-Rv1274;Dbxref=EnsemblGenomes-Gn:Rv1274,EnsemblGenomes-Tr:CCP44030,GOA:P9WK53,InterPro:IPR024520,NCBI_GP:CCP44030.1;Name=CCP44030.1;Note=Rv1274%2C (MTCY50.08c)%2C len: 185 aa. Possible lprB%2Clipoprotein%3B contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Some similarity to Rv1275. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprB;locus_tag=Rv1274;product=Possible lipoprotein LprB;protein_id=CCP44030.1;transl_table=11
AL123456.3	EMBL	gene	1424751	1425293	.	+	.	ID=gene-Rv1275;Name=lprC;gbkey=Gene;gene=lprC;gene_biotype=protein_coding;locus_tag=Rv1275
AL123456.3	EMBL	CDS	1424751	1425293	.	+	0	ID=cds-CCP44031.1;Parent=gene-Rv1275;Dbxref=EnsemblGenomes-Gn:Rv1275,EnsemblGenomes-Tr:CCP44031,GOA:O86337,InterPro:IPR024520,UniProtKB/TrEMBL:O86337,NCBI_GP:CCP44031.1;Name=CCP44031.1;Note=Rv1275%2C (MTCY50.07c)%2C len: 180 aa. Possible lprC%2Clipoprotein%3B contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Some similarity to Rv1274. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprC;locus_tag=Rv1275;product=Possible lipoprotein LprC;protein_id=CCP44031.1;transl_table=11
AL123456.3	EMBL	gene	1425438	1425914	.	-	.	ID=gene-Rv1276c;Name=Rv1276c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1276c
AL123456.3	EMBL	CDS	1425438	1425914	.	-	0	ID=cds-CCP44032.1;Parent=gene-Rv1276c;Dbxref=EnsemblGenomes-Gn:Rv1276c,EnsemblGenomes-Tr:CCP44032,GOA:P9WGF9,InterPro:IPR013078,InterPro:IPR029033,NCBI_GP:CCP44032.1;Name=CCP44032.1;Note=Rv1276c%2C (MTCY50.06)%2C len: 158 aa. Conserved hypothetical protein%2C similar to AL096844|SCI28.03 hypothetical protein from Streptomyces coelicolor (172 aa)%2CFASTA scores: opt: 385%2C E(): 3.3e-19%2C (43.5%25 identity in 161 aa overlap). Some similarity to P76502|SIXA_ECOLI phosphohistidine phosphatase SIXA (161 aa)%2C FASTA scores: opt: 146%2C E(): 0.0047%2C (31.9%25 identity in 116 aa overlap). Belongs to the SixA family of phosphatases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1276c;product=Conserved hypothetical protein;protein_id=CCP44032.1;transl_table=11
AL123456.3	EMBL	gene	1426164	1427417	.	+	.	ID=gene-Rv1277;Name=Rv1277;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1277
AL123456.3	EMBL	CDS	1426164	1427417	.	+	0	ID=cds-CCP44033.1;Parent=gene-Rv1277;Dbxref=EnsemblGenomes-Gn:Rv1277,EnsemblGenomes-Tr:CCP44033,GOA:Q50699,InterPro:IPR004843,InterPro:IPR014577,InterPro:IPR029052,UniProtKB/TrEMBL:Q50699,NCBI_GP:CCP44033.1;Name=CCP44033.1;Note=Rv1277%2C (MTCY50.05c)%2C len: 417 aa. Conserved hypothetical protein%2C some similarity to 3914967|O68033|SBCD_RHOCA exonuclease SBCD homolog from Rhodobacter capsulatus (405 aa). May be sbcD protein (see Mizrahi %26 Andersen 1998);gbkey=CDS;locus_tag=Rv1277;product=Conserved hypothetical protein;protein_id=CCP44033.1;transl_table=11
AL123456.3	EMBL	gene	1427414	1430041	.	+	.	ID=gene-Rv1278;Name=Rv1278;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1278
AL123456.3	EMBL	CDS	1427414	1430041	.	+	0	ID=cds-CCP44034.1;Parent=gene-Rv1278;Dbxref=EnsemblGenomes-Gn:Rv1278,EnsemblGenomes-Tr:CCP44034,GOA:P9WM41,InterPro:IPR027417,NCBI_GP:CCP44034.1;Name=CCP44034.1;Note=Rv1278%2C (MTCY50.04c)%2C len: 875 aa. Hypothetical unknown protein%2C possible coiled-coil regions%2C contains PS00017 ATP/GTP-binding site motif A. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1278;product=Hypothetical protein;protein_id=CCP44034.1;transl_table=11
AL123456.3	EMBL	gene	1430062	1431648	.	+	.	ID=gene-Rv1279;Name=Rv1279;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1279
AL123456.3	EMBL	CDS	1430062	1431648	.	+	0	ID=cds-CCP44035.1;Parent=gene-Rv1279;Dbxref=EnsemblGenomes-Gn:Rv1279,EnsemblGenomes-Tr:CCP44035,GOA:P9WMV5,InterPro:IPR000172,InterPro:IPR007867,InterPro:IPR012132,NCBI_GP:CCP44035.1;Name=CCP44035.1;Note=Rv1279%2C (MTCY50.03c)%2C len: 528 aa. Probable dehydrogenase%2C FAD flavoprotein GMC oxidoreductase%2C similar to several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from Escherichia coli (556 aa)%2C FASTA scores%2C opt: 1047%2CE(): 0%2C (37.7%25 identity in 541 aa overlap). Similar to Rv0697 putative Mycobacterium tuberculosis GMC oxidoreductase. Contains PS00623 GMC oxidoreductases signature 1%2C and PS00624 GMC oxidoreductases signature 2. Belongs to the GMC oxidoreductases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00624;locus_tag=Rv1279;product=Probable dehydrogenase FAD flavoprotein GMC oxidoreductase;protein_id=CCP44035.1;transl_table=11
AL123456.3	EMBL	gene	1431665	1433440	.	-	.	ID=gene-Rv1280c;Name=oppA;gbkey=Gene;gene=oppA;gene_biotype=protein_coding;locus_tag=Rv1280c
AL123456.3	EMBL	CDS	1431665	1433440	.	-	0	ID=cds-CCP44036.1;Parent=gene-Rv1280c;Dbxref=EnsemblGenomes-Gn:Rv1280c,EnsemblGenomes-Tr:CCP44036,GOA:P9WGU5,InterPro:IPR000914,NCBI_GP:CCP44036.1;Name=CCP44036.1;Note=Rv1280c%2C (MTCY50.02)%2C len: 591 aa. Probable oppA%2Coligopeptide-binding lipoprotein component of peptide transport system (see citation below)%2C sharing some similarity to other periplasmic solute binding proteins e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding protein from Salmonella typhimurium (542 aa)%2C FASTA scores: E(): 5.1e-05%2C (22.1%25 identity in 458 aa overlap)%3B etc. Also similar to Rv1166 and Rv2585c from Mycobacterium tuberculosis. Has possible N-terminal signal sequence and prokaryotic lipoprotein lipid attachment site (PS00013). Belongs to the bacterial extracellular solute-binding protein family 5.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=oppA;locus_tag=Rv1280c;product=Probable periplasmic oligopeptide-binding lipoprotein OppA;protein_id=CCP44036.1;transl_table=11
AL123456.3	EMBL	gene	1433433	1435271	.	-	.	ID=gene-Rv1281c;Name=oppD;gbkey=Gene;gene=oppD;gene_biotype=protein_coding;locus_tag=Rv1281c
AL123456.3	EMBL	CDS	1433433	1435271	.	-	0	ID=cds-CCP44037.1;Parent=gene-Rv1281c;Dbxref=EnsemblGenomes-Gn:Rv1281c,EnsemblGenomes-Tr:CCP44037,GOA:P9WQJ5,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR010066,InterPro:IPR013563,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP44037.1;Name=CCP44037.1;Note=Rv1281c%2C (MTCY50.01)%2C len: 612 aa. Probable oppD%2Coligopeptide-transport ATP-binding protein ABC transporter (see citation below)%2C similar to others e.g. DPPD_BACSU|P26905 dipeptide transport ATP-binding protein from Bacillus subtilis (335 aa)%2C FASTA scores: opt: 983%2CE(): 0%2C (48.6%25 identity in 319 aa overlap)%3B etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop)%3B 2 x PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=oppD;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1281c;product=Probable oligopeptide-transport ATP-binding protein ABC transporter OppD;protein_id=CCP44037.1;transl_table=11
AL123456.3	EMBL	gene	1435268	1436143	.	-	.	ID=gene-Rv1282c;Name=oppC;gbkey=Gene;gene=oppC;gene_biotype=protein_coding;locus_tag=Rv1282c
AL123456.3	EMBL	CDS	1435268	1436143	.	-	0	ID=cds-CCP44038.1;Parent=gene-Rv1282c;Dbxref=EnsemblGenomes-Gn:Rv1282c,EnsemblGenomes-Tr:CCP44038,GOA:P9WFZ9,InterPro:IPR000515,InterPro:IPR025966,NCBI_GP:CCP44038.1;Name=CCP44038.1;Note=Rv1282c%2C (MTCY373.01c-MTCY3H3.01)%2C len: 291 aa. Probable oppC%2C oligopeptide-transport integral membrane protein ABC transporter (see Braibant et al.%2C 2000)%2Csimilar to other integral membrane proteins e.g. OPPC_ECOLI|P77664 oligopeptide transport system permease from Escherichia coli (302 aa)%2C FASTA scores: E(): 4.6e-33%2C(40.7%25 identity in 275 aa overlap)%3B etc. Also similar to Rv3664c|DPPC probable peptide-transport integral membrane protein from Mycobacterium tuberculosis.;gbkey=CDS;gene=oppC;locus_tag=Rv1282c;product=Probable oligopeptide-transport integral membrane protein ABC transporter OppC;protein_id=CCP44038.1;transl_table=11
AL123456.3	EMBL	gene	1436140	1437117	.	-	.	ID=gene-Rv1283c;Name=oppB;gbkey=Gene;gene=oppB;gene_biotype=protein_coding;locus_tag=Rv1283c
AL123456.3	EMBL	CDS	1436140	1437117	.	-	0	ID=cds-CCP44039.1;Parent=gene-Rv1283c;Dbxref=EnsemblGenomes-Gn:Rv1283c,EnsemblGenomes-Tr:CCP44039,GOA:P9WFZ7,InterPro:IPR000515,NCBI_GP:CCP44039.1;Name=CCP44039.1;Note=Rv1283c%2C (MTCY373.02c)%2C len: 325 aa. Probable oppB%2Coligopeptide-transport integral membrane protein ABC transporter (see citation below)%2C similar to other integral membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide transport system permease protein from Escherichia coli (339 aa)%2C FASTA scores: opt: 402%2C E(): 3.4e-20%2C (31.0%25 identity in 345 aa overlap)%3B etc. Also similar to Rv3665c|DppB probable peptide-transport integral membrane protein from Mycobacterium tuberculosis. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.;gbkey=CDS;gene=oppB;inference=protein motif:PROSITE:PS00402;locus_tag=Rv1283c;product=Probable oligopeptide-transport integral membrane protein ABC transporter OppB;protein_id=CCP44039.1;transl_table=11
AL123456.3	EMBL	gene	1437324	1437815	.	+	.	ID=gene-Rv1284;Name=canA;gbkey=Gene;gene=canA;gene_biotype=protein_coding;locus_tag=Rv1284
AL123456.3	EMBL	CDS	1437324	1437815	.	+	0	ID=cds-CCP44040.1;Parent=gene-Rv1284;Dbxref=EnsemblGenomes-Gn:Rv1284,EnsemblGenomes-Tr:CCP44040,GOA:P9WPJ7,InterPro:IPR001765,PDB:1YLK,NCBI_GP:CCP44040.1;Name=CCP44040.1;Note=Rv1284%2C (MTCY373.03)%2C len: 163 aa. CanA%2CBeta-carbonic anhydrase%2C proven biochemically (See Suarez Covarrubias et al. 2005) similar to others e.g. AL109663|SC4A10.26 hypothetical protein from Streptomyces coelicolor (167 aa)%2C FASTA scores: opt: 567%2C E(): 1.5e-32%2C(53.4%25 identity in 163 aa overla)%3B shows some similarity to hypothetical protein from Methanobacterium thermoautotrophicum. Weak similarity to carbonic anhydrases e.g. U51624|MTU516242|P17582 Methanothermobacter thermautotrophicus (171 aa)%2C FASTA score: opt: 305%2C E(): 1.2e-14%2C (35.2%25 identity in 165 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=canA;locus_tag=Rv1284;product=Beta-carbonic anhydrase;protein_id=CCP44040.1;transl_table=11
AL123456.3	EMBL	gene	1437909	1438907	.	+	.	ID=gene-Rv1285;Name=cysD;gbkey=Gene;gene=cysD;gene_biotype=protein_coding;locus_tag=Rv1285
AL123456.3	EMBL	CDS	1437909	1438907	.	+	0	ID=cds-CCP44041.1;Parent=gene-Rv1285;Dbxref=EnsemblGenomes-Gn:Rv1285,EnsemblGenomes-Tr:CCP44041,GOA:P9WIK1,InterPro:IPR002500,InterPro:IPR011784,InterPro:IPR014729,NCBI_GP:CCP44041.1;Name=CCP44041.1;Note=Rv1285%2C (MTCY373.04)%2C len: 332 aa. Probable cysD%2Csulfate adenylyltransferase subunit 2 (see Wooff et al.%2C2002)%2C homology suggests start site at aa 24 or 28%2C similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate transferase subunit 2 from Escherichia coli (302 aa)%2C FASTA score: opt: 973%2C E():0%2C (52.5%25 identity in 303 aa overlap). Also similar to Mycobacterium tuberculosis Rv2392%2C3'-phosphoadenylylsulfate reductase. Belongs to the PAPS reductase family. CYSD subfamily. Thought to be differentially expressed within host cells (see Triccas et al.%2C 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysD;locus_tag=Rv1285;product=Probable sulfate adenylyltransferase subunit 2 CysD;protein_id=CCP44041.1;transl_table=11
AL123456.3	EMBL	gene	1438907	1440751	.	+	.	ID=gene-Rv1286;Name=cysN;gbkey=Gene;gene=cysN;gene_biotype=protein_coding;locus_tag=Rv1286
AL123456.3	EMBL	CDS	1438907	1440751	.	+	0	ID=cds-CCP44042.1;Parent=gene-Rv1286;Dbxref=EnsemblGenomes-Gn:Rv1286,EnsemblGenomes-Tr:CCP44042,GOA:P9WNM5,InterPro:IPR000795,InterPro:IPR002891,InterPro:IPR004161,InterPro:IPR009000,InterPro:IPR009001,InterPro:IPR011779,InterPro:IPR027417,PDB:4BZQ,PDB:4BZX,NCBI_GP:CCP44042.1;Name=CCP44042.1;Note=Rv1286%2C (MTCY373.05)%2C len: 614 aa. Probable cysN/cysC bifunctional enzyme%2C sulfate adenylyltransferase subunit 1 and Adenylylsulfate kinase (see Wooff et al.%2C2002)%2C similar to CYSN_ECOLI|P23845 sulfate adenylate transferase subunit 1 from Escherichia coli (475 aa)%2C FASTA scores: opt: 1291%2C E():0%2C (50.2%25 identity in 428 aa overlap). Contains 2 x PS00017 ATP/GTP-binding site motif A%2C PS00301 GTP-binding elongation factors signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysN;inference=protein motif:PROSITE:PS00301;locus_tag=Rv1286;product=Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase;protein_id=CCP44042.1;transl_table=11
AL123456.3	EMBL	gene	1440805	1441290	.	+	.	ID=gene-Rv1287;Name=Rv1287;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1287
AL123456.3	EMBL	CDS	1440805	1441290	.	+	0	ID=cds-CCP44043.1;Parent=gene-Rv1287;Dbxref=EnsemblGenomes-Gn:Rv1287,EnsemblGenomes-Tr:CCP44043,GOA:P9WME3,InterPro:IPR000944,InterPro:IPR011991,NCBI_GP:CCP44043.1;Name=CCP44043.1;Note=Rv1287%2C (MTCY373.06)%2C len: 161 aa. Conserved hypothetical protein%2C similar to VjeB family of proteins e.g. FASTA score: P44675|Y379_HAEIN hypothetical protein HI0379 (150 aa)%2C FASTA scores: opt: 213%2C E(): 2.5e-08%2C(30.0%25 identity in 130 aa overlap) and YJEB_ECOLI|P21498 hypothetical 15.6 kDa protein in pura-vacb (141 aa)%2C opt: 167%2C E(): 9.5e-06%2C (25.0%25 identity in 136 aa overlap). Belongs to the UPF0074 (RFF2) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1287;product=Conserved hypothetical protein;protein_id=CCP44043.1;transl_table=11
AL123456.3	EMBL	gene	1441348	1442718	.	+	.	ID=gene-Rv1288;Name=Rv1288;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1288
AL123456.3	EMBL	CDS	1441348	1442718	.	+	0	ID=cds-CCP44044.1;Parent=gene-Rv1288;Dbxref=EnsemblGenomes-Gn:Rv1288,EnsemblGenomes-Tr:CCP44044,InterPro:IPR000801,InterPro:IPR008861,InterPro:IPR018392,InterPro:IPR029058,NCBI_GP:CCP44044.1;Name=CCP44044.1;Note=Rv1288%2C (MTCY373.07)%2C len: 456 aa. Conserved protein%2C some similarity to A85B_MYCTU|P31952 antigen 85-b precursor (85b) (325 aa)%2C FASTA scores: opt: 199%2C E(): 2.7e-06%2C (24.7%25 identity in 279 aa overlap). Also similar to Q01377|CSP1_CORGL PS1 protein precursor (related to antigen 85 complex) from Corynebacterium glutamicum (657 aa)%2C FASTA scores: opt: 280%2C E(): 1.9e-10%2C (26.4%25 identity in 352 aa overlap). Seems to contain 3 LYSM repeats;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1288;product=Conserved protein;protein_id=CCP44044.1;transl_table=11
AL123456.3	EMBL	gene	1442767	1443399	.	+	.	ID=gene-Rv1289;Name=Rv1289;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1289
AL123456.3	EMBL	CDS	1442767	1443399	.	+	0	ID=cds-CCP44045.1;Parent=gene-Rv1289;Dbxref=EnsemblGenomes-Gn:Rv1289,EnsemblGenomes-Tr:CCP44045,GOA:P9WM37,NCBI_GP:CCP44045.1;Name=CCP44045.1;Note=Rv1289%2C (MTCY373.08)%2C len: 210 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1289;product=Unknown protein;protein_id=CCP44045.1;transl_table=11
AL123456.3	EMBL	gene	1443482	1445047	.	-	.	ID=gene-Rv1290c;Name=Rv1290c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1290c
AL123456.3	EMBL	CDS	1443482	1445047	.	-	0	ID=cds-CCP44046.1;Parent=gene-Rv1290c;Dbxref=EnsemblGenomes-Gn:Rv1290c,EnsemblGenomes-Tr:CCP44046,GOA:P9WM35,InterPro:IPR018723,NCBI_GP:CCP44046.1;Name=CCP44046.1;Note=Rv1290c%2C (MTCY373.09c)%2C len: 521 aa. Conserved protein (see citation below)%2C similar to AL031013|SC8A6.09 hypothetical protein from Streptomyces coelicolor (443 aa)%2CFASTA scores: opt: 371%2C E(): 9.5e-17%2C (28.3%25 identity in 446 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1290c;product=Conserved protein;protein_id=CCP44046.1;transl_table=11
AL123456.3	EMBL	gene	1445058	1445372	.	+	.	ID=gene-Rv1290A;Name=Rv1290A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1290A
AL123456.3	EMBL	CDS	1445058	1445372	.	+	0	ID=cds-CCP44047.1;Parent=gene-Rv1290A;Dbxref=EnsemblGenomes-Gn:Rv1290A,EnsemblGenomes-Tr:CCP44047,UniProtKB/TrEMBL:Q79FQ6,NCBI_GP:CCP44047.1;Name=CCP44047.1;Note=Rv1290A%2C len: 104 aa. Hypothetical unknown protein%2Cequivalent to AAK45590 from Mycobacterium tuberculosis strain CDC1551 (122 aa) but shorter 18 aa.;gbkey=CDS;locus_tag=Rv1290A;product=Hypothetical protein;protein_id=CCP44047.1;transl_table=11
AL123456.3	EMBL	gene	1445499	1445834	.	-	.	ID=gene-Rv1291c;Name=Rv1291c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1291c
AL123456.3	EMBL	CDS	1445499	1445834	.	-	0	ID=cds-CCP44048.1;Parent=gene-Rv1291c;Dbxref=EnsemblGenomes-Gn:Rv1291c,EnsemblGenomes-Tr:CCP44048,InterPro:IPR007969,NCBI_GP:CCP44048.1;Name=CCP44048.1;Note=Rv1291c%2C (MTCY373.10c)%2C len: 111 aa. Conserved hypothetical secreted protein%2C similar to others in Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU hypothetical 11.6 kDa protein (113 aa)%2C FASTA score: opt: 246%2C E(): 1.7e-09%2C (40.0%25 identity in 110 aa overlap)%3B Rv1804c%2C Rv1810%2C Rv0622%2C etc.;gbkey=CDS;locus_tag=Rv1291c;product=Conserved hypothetical secreted protein;protein_id=CCP44048.1;transl_table=11
AL123456.3	EMBL	gene	1446193	1446265	.	-	.	ID=gene-argV;Name=argV;gbkey=Gene;gene=argV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1446193	1446265	.	-	.	ID=rna-argV;Parent=gene-argV;Note=codon recognized: CGG%3B argV%2C tRNA-Arg%2C anticodon ccg%2C length %3D 73;anticodon=(pos:complement(1446230..1446232));gbkey=tRNA;gene=argV;product=tRNA-Arg
AL123456.3	EMBL	exon	1446193	1446265	.	-	.	ID=exon-argV-1;Parent=rna-argV;Note=codon recognized: CGG%3B argV%2C tRNA-Arg%2C anticodon ccg%2C length %3D 73;anticodon=(pos:complement(1446230..1446232));gbkey=tRNA;gene=argV;product=tRNA-Arg
AL123456.3	EMBL	gene	1446379	1448031	.	+	.	ID=gene-Rv1292;Name=argS;gbkey=Gene;gene=argS;gene_biotype=protein_coding;locus_tag=Rv1292
AL123456.3	EMBL	CDS	1446379	1448031	.	+	0	ID=cds-CCP44049.1;Parent=gene-Rv1292;Dbxref=EnsemblGenomes-Gn:Rv1292,EnsemblGenomes-Tr:CCP44049,GOA:P9WFW5,InterPro:IPR001278,InterPro:IPR001412,InterPro:IPR005148,InterPro:IPR008909,InterPro:IPR009080,InterPro:IPR014729,NCBI_GP:CCP44049.1;Name=CCP44049.1;Note=Rv1292%2C (MTCY373.12)%2C len: 550 aa. Probable argS%2CArginyl-tRNA synthetase%2C highly similar to SYR_MYCLE|P45840 Mycobacterium leprae (550 aa)%2C FASTA scores: opt: 3115%2CE(): 0%2C (84.9%25 identity in 550 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argS;inference=protein motif:PROSITE:PS00178;locus_tag=Rv1292;product=Probable arginyl-tRNA synthetase ArgS (ARGRS) (arginine--tRNA ligase);protein_id=CCP44049.1;transl_table=11
AL123456.3	EMBL	gene	1448028	1449371	.	+	.	ID=gene-Rv1293;Name=lysA;gbkey=Gene;gene=lysA;gene_biotype=protein_coding;locus_tag=Rv1293
AL123456.3	EMBL	CDS	1448028	1449371	.	+	0	ID=cds-CCP44050.1;Parent=gene-Rv1293;Dbxref=EnsemblGenomes-Gn:Rv1293,EnsemblGenomes-Tr:CCP44050,GOA:P9WIU7,InterPro:IPR000183,InterPro:IPR002986,InterPro:IPR009006,InterPro:IPR022643,InterPro:IPR022644,InterPro:IPR022653,InterPro:IPR022657,InterPro:IPR029066,PDB:1HKV,PDB:1HKW,PDB:2O0T,NCBI_GP:CCP44050.1;Name=CCP44050.1;Note=Rv1293%2C (MTCY373.13)%2C len: 447 aa. lysA%2Cdiaminopimelate decarboxylase (see citation below)%2C almost identical to DCDA_MYCTU|P31848. Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site%2C PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. Belongs to family 2 of ornithine%2C DAP%2C and arginine decarboxylases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lysA;inference=protein motif:PROSITE:PS00879;locus_tag=Rv1293;product=Diaminopimelate decarboxylase LysA (DAP decarboxylase);protein_id=CCP44050.1;transl_table=11
AL123456.3	EMBL	gene	1449375	1450700	.	+	.	ID=gene-Rv1294;Name=thrA;gbkey=Gene;gene=thrA;gene_biotype=protein_coding;locus_tag=Rv1294
AL123456.3	EMBL	CDS	1449375	1450700	.	+	0	ID=cds-CCP44051.1;Parent=gene-Rv1294;Dbxref=EnsemblGenomes-Gn:Rv1294,EnsemblGenomes-Tr:CCP44051,GOA:P9WPX1,InterPro:IPR001342,InterPro:IPR002912,InterPro:IPR005106,InterPro:IPR016040,InterPro:IPR016204,InterPro:IPR019811,NCBI_GP:CCP44051.1;Name=CCP44051.1;Note=Rv1294%2C (MTCY373.14)%2C len: 441 aa. Probable thrA (hom)%2C homoserine dehydrogenase%2C highly similar to DHOM_MYCLE|P46806 from Mycobacterium leprae (441 aa)%2C FASTA scores: opt: 2437%2C E():0%2C (89.5%25 identity in 438 aa overlap). Contains PS00017 ATP/GTP-binding site motif A%3B PS01042 Homoserine dehydrogenase signature. Belongs to the homoserine dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thrA;inference=protein motif:PROSITE:PS01042;locus_tag=Rv1294;product=Probable homoserine dehydrogenase ThrA;protein_id=CCP44051.1;transl_table=11
AL123456.3	EMBL	gene	1450697	1451779	.	+	.	ID=gene-Rv1295;Name=thrC;gbkey=Gene;gene=thrC;gene_biotype=protein_coding;locus_tag=Rv1295
AL123456.3	EMBL	CDS	1450697	1451779	.	+	0	ID=cds-CCP44052.1;Parent=gene-Rv1295;Dbxref=EnsemblGenomes-Gn:Rv1295,EnsemblGenomes-Tr:CCP44052,GOA:P9WG59,InterPro:IPR000634,InterPro:IPR001926,InterPro:IPR004450,InterPro:IPR026260,PDB:2D1F,NCBI_GP:CCP44052.1;Name=CCP44052.1;Note=Rv1295%2C (MTCY373.15)%2C len: 360 aa. thrC%2C threonine synthase (see Parish et al.%2C 1999)%2C highly similar to THRC_MYCLE|P45837 Mycobacterium leprae (360 aa)%2C FASTA scores: opt: 2202%2C E(): 0%2C (93.9%25 identity in 359 aa overlap). Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thrC;inference=protein motif:PROSITE:PS00165;locus_tag=Rv1295;product=Threonine synthase ThrC (ts);protein_id=CCP44052.1;transl_table=11
AL123456.3	EMBL	gene	1451997	1452947	.	+	.	ID=gene-Rv1296;Name=thrB;gbkey=Gene;gene=thrB;gene_biotype=protein_coding;locus_tag=Rv1296
AL123456.3	EMBL	CDS	1451997	1452947	.	+	0	ID=cds-CCP44053.1;Parent=gene-Rv1296;Dbxref=EnsemblGenomes-Gn:Rv1296,EnsemblGenomes-Tr:CCP44053,GOA:P9WKE7,InterPro:IPR000870,InterPro:IPR006203,InterPro:IPR006204,InterPro:IPR013750,InterPro:IPR014721,InterPro:IPR020568,NCBI_GP:CCP44053.1;Name=CCP44053.1;Note=Rv1296%2C (MTCY373.16)%2C len: 316 aa. Probable thrB%2Chomoserine kinase (see citation below)%2C highly similar to KHSE_MYCLE|P45836 from Mycobacterium leprae (314 aa)%2C FASTA scores%2C opt: 1657%2C E(): 0%2C (82.0%25 identity in 311 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site%2C and PS00627 GHMP kinases putative ATP-binding domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thrB;inference=protein motif:PROSITE:PS00639;locus_tag=Rv1296;product=Probable homoserine kinase ThrB;protein_id=CCP44053.1;transl_table=11
AL123456.3	EMBL	gene	1453204	1455012	.	+	.	ID=gene-Rv1297;Name=rho;gbkey=Gene;gene=rho;gene_biotype=protein_coding;locus_tag=Rv1297
AL123456.3	EMBL	CDS	1453204	1455012	.	+	0	ID=cds-CCP44054.1;Parent=gene-Rv1297;Dbxref=EnsemblGenomes-Gn:Rv1297,EnsemblGenomes-Tr:CCP44054,GOA:P9WHF3,InterPro:IPR000194,InterPro:IPR003593,InterPro:IPR004665,InterPro:IPR011112,InterPro:IPR011113,InterPro:IPR011129,InterPro:IPR012340,InterPro:IPR027417,NCBI_GP:CCP44054.1;Name=CCP44054.1;Note=Rv1297%2C (MTCY373.17)%2C len: 602 aa. Probable rho%2Ctranscription termination factor homolog%2C highly similar to many e.g. RHO_MYCLE|P45835 Mycobacterium leprae (610 aa)%2CFASTA scores: (81.5%25 identity in 612 aa overlap). Contains 1 RNA recognition motif (RRM). Nucleotide position 1453608 in the genome sequence has been corrected%2C T:C resulting in G135G.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rho;locus_tag=Rv1297;product=Probable transcription termination factor Rho homolog;protein_id=CCP44054.1;transl_table=11
AL123456.3	EMBL	gene	1455163	1455405	.	+	.	ID=gene-Rv1298;Name=rpmE;gbkey=Gene;gene=rpmE;gene_biotype=protein_coding;locus_tag=Rv1298
AL123456.3	EMBL	CDS	1455163	1455405	.	+	0	ID=cds-CCP44055.1;Parent=gene-Rv1298;Dbxref=EnsemblGenomes-Gn:Rv1298,EnsemblGenomes-Tr:CCP44055,GOA:P9WHA1,InterPro:IPR002150,InterPro:IPR027491,NCBI_GP:CCP44055.1;Name=CCP44055.1;Note=Rv1298%2C (MTCY373.18)%2C len: 80 aa. rpmE%2C 50s ribosomal protein L31%2C highly similar to many e.g. RL31_MYCLE|P45834 50s ribosomal protein L31 from Mycobacterium leprae (84 aa)%2C FASTA scores: opt: 490%2C E(): 5.5e-28%2C (89.6%25 identity in 77 aa overlap). Contains PS01143 Ribosomal protein L31 signature. Belongs to the L31P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpmE;inference=protein motif:PROSITE:PS01143;locus_tag=Rv1298;product=50S ribosomal protein L31 RpmE;protein_id=CCP44055.1;transl_table=11
AL123456.3	EMBL	gene	1455495	1456568	.	+	.	ID=gene-Rv1299;Name=prfA;gbkey=Gene;gene=prfA;gene_biotype=protein_coding;locus_tag=Rv1299
AL123456.3	EMBL	CDS	1455495	1456568	.	+	0	ID=cds-CCP44056.1;Parent=gene-Rv1299;Dbxref=EnsemblGenomes-Gn:Rv1299,EnsemblGenomes-Tr:CCP44056,GOA:P9WHG3,InterPro:IPR000352,InterPro:IPR004373,InterPro:IPR005139,InterPro:IPR014720,NCBI_GP:CCP44056.1;Name=CCP44056.1;Note=Rv1299%2C (MTCY373.19)%2C len: 357 aa. Probable prfA%2Cpeptide chain release factor 1 (rf-1)%2C highly similar to many e.g. RF1_MYCLE|P45833 peptide chain release factor 1 (rf-1) from Mycobacterium leprae (357 aa)%2C FASTA scores: opt: 2047%2C E(): 0%2C (89.3%25 identity in 356 aa overlap)%3B also similar to Mycobacterium tuberculosis Rv3105c%2C prfB peptide chain release factor 2. Contains PS00745 Prokaryotic-type class I peptide chain release factors signature. Belongs to the prokaryotic and mitochondrial release factors family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prfA;inference=protein motif:PROSITE:PS00745;locus_tag=Rv1299;product=Probable peptide chain release factor 1 PrfA (RF-1);protein_id=CCP44056.1;transl_table=11
AL123456.3	EMBL	gene	1456565	1457542	.	+	.	ID=gene-Rv1300;Name=hemK;gbkey=Gene;gene=hemK;gene_biotype=protein_coding;locus_tag=Rv1300
AL123456.3	EMBL	CDS	1456565	1457542	.	+	0	ID=cds-CCP44057.1;Parent=gene-Rv1300;Dbxref=EnsemblGenomes-Gn:Rv1300,EnsemblGenomes-Tr:CCP44057,GOA:P9WHV3,InterPro:IPR002052,InterPro:IPR004556,InterPro:IPR019874,InterPro:IPR029063,NCBI_GP:CCP44057.1;Name=CCP44057.1;Note=Rv1300%2C (MTCY373.20)%2C len: 325 aa. Probable hemK protein homolog%2C homology suggests translation may start at aa 22%2C highly similar to many e.g. HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa)%2C FASTA scores: opt: 936%2C E(): 0%2C (76.7%25 identity in 189 aa overlap). Belongs to the HemK family of modification methylases.;gbkey=CDS;gene=hemK;locus_tag=Rv1300;product=Probable HemK protein homolog HemK;protein_id=CCP44057.1;transl_table=11
AL123456.3	EMBL	repeat_region	1456585	1456627	.	+	.	ID=id-Rv1300;Note=43 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region;gene=hemK;locus_tag=Rv1300
AL123456.3	EMBL	repeat_region	1457453	1457504	.	+	.	ID=id-Rv1300-2;Note=52 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region;gene=hemK;locus_tag=Rv1300
AL123456.3	EMBL	repeat_region	1457505	1457557	.	+	.	ID=id-AL123456.3:1457505..1457557;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	1457558	1458211	.	+	.	ID=gene-Rv1301;Name=Rv1301;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1301
AL123456.3	EMBL	CDS	1457558	1458211	.	+	0	ID=cds-CCP44058.1;Parent=gene-Rv1301;Dbxref=EnsemblGenomes-Gn:Rv1301,EnsemblGenomes-Tr:CCP44058,GOA:P9WGC9,InterPro:IPR006070,InterPro:IPR017945,NCBI_GP:CCP44058.1;Name=CCP44058.1;Note=Rv1301%2C (MTCY373.21)%2C len: 217 aa. Conserved protein%2C highly similar to YRFE_MYCLE|P45831 hypothetical 22.7 kDa protein in rfe-hemk intergenic region%2C (220 aa)%2CFASTA scores: opt: 1168%2C E(): 0%2C (82.8%25 identity in 215 aa overlap). Contains PS01147 Hypothetical SUA5/yciO/yrdC family signature. Belongs to the SUA5/YRDC/YCIO/YWLC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01147;locus_tag=Rv1301;product=Conserved protein;protein_id=CCP44058.1;transl_table=11
AL123456.3	EMBL	gene	1458295	1459509	.	+	.	ID=gene-Rv1302;Name=rfe;gbkey=Gene;gene=rfe;gene_biotype=protein_coding;gene_synonym=wecA;locus_tag=Rv1302
AL123456.3	EMBL	CDS	1458295	1459509	.	+	0	ID=cds-CCP44059.1;Parent=gene-Rv1302;Dbxref=EnsemblGenomes-Gn:Rv1302,EnsemblGenomes-Tr:CCP44059,GOA:P9WMW5,InterPro:IPR000715,NCBI_GP:CCP44059.1;Name=CCP44059.1;Note=Rv1302%2C (MTCY373.22)%2C len: 404 aa. Probable rfe (alternate gene name: wecA)%2C undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase (see citation below)%2Cequivalent to RFE_MYCLE|P45830 Mycobacterium leprae (398 aa)%2C FASTA scores%2C opt: 2285%2C E(): 0%2C (89.2%25 identity in 398 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rfe;locus_tag=Rv1302;product=Probable undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe (UDP-GlcNAc transferase);protein_id=CCP44059.1;transl_table=11
AL123456.3	EMBL	gene	1459766	1460251	.	+	.	ID=gene-Rv1303;Name=Rv1303;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1303
AL123456.3	EMBL	CDS	1459766	1460251	.	+	0	ID=cds-CCP44060.1;Parent=gene-Rv1303;Dbxref=EnsemblGenomes-Gn:Rv1303,EnsemblGenomes-Tr:CCP44060,GOA:P9WM31,InterPro:IPR005598,NCBI_GP:CCP44060.1;Name=CCP44060.1;Note=Rv1303%2C (MTCY373.23)%2C len: 161 aa. Conserved hypothetical transmembrane protein%2C highly similar to P53431|Y02N_MYCLE hypothetical Mycobacterium leprae protein (153 aa)%2C FASTA score: opt: 636%2C E():0%2C (69.8%25 identity in 149 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1303;product=Conserved hypothetical transmembrane protein;protein_id=CCP44060.1;transl_table=11
AL123456.3	EMBL	gene	1460244	1460996	.	+	.	ID=gene-Rv1304;Name=atpB;gbkey=Gene;gene=atpB;gene_biotype=protein_coding;locus_tag=Rv1304
AL123456.3	EMBL	CDS	1460244	1460996	.	+	0	ID=cds-CCP44061.1;Parent=gene-Rv1304;Dbxref=EnsemblGenomes-Gn:Rv1304,EnsemblGenomes-Tr:CCP44061,GOA:P9WPV7,InterPro:IPR000568,InterPro:IPR023011,NCBI_GP:CCP44061.1;Name=CCP44061.1;Note=Rv1304%2C (MTCY373.24)%2C len: 250 aa. Probable atpB%2CATP synthase a chain%2C highly similar to ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa)%2C FASTA scores: opt: 1382%2CE(): 0%2C (84.0%25 identity in 250 aa overlap). Contains PS00449 ATP synthase a subunit signature. subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2C beta(3)%2C gamma(1)%2C delta(1)%2Cepsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase a chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atpB;inference=protein motif:PROSITE:PS00449;locus_tag=Rv1304;product=Probable ATP synthase a chain AtpB (protein 6);protein_id=CCP44061.1;transl_table=11
AL123456.3	EMBL	gene	1461045	1461290	.	+	.	ID=gene-Rv1305;Name=atpE;gbkey=Gene;gene=atpE;gene_biotype=protein_coding;locus_tag=Rv1305
AL123456.3	EMBL	CDS	1461045	1461290	.	+	0	ID=cds-CCP44062.1;Parent=gene-Rv1305;Dbxref=EnsemblGenomes-Gn:Rv1305,EnsemblGenomes-Tr:CCP44062,GOA:P9WPS1,InterPro:IPR000454,InterPro:IPR002379,InterPro:IPR005953,InterPro:IPR020537,NCBI_GP:CCP44062.1;Name=CCP44062.1;Note=Rv1305%2C (MTCY373.25)%2C len: 81 aa. Probable atpE%2C ATP synthase C chain%2C highly similar to P45828|ATPL_MYCLE Mycobacterium leprae (92.6%25 identity in 81 aa overlap). Contains PS00605 ATP synthase C subunit signature. subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2C beta(3)%2C gamma(1)%2C delta(1)%2Cepsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase C chain family.;gbkey=CDS;gene=atpE;inference=protein motif:PROSITE:PS00605;locus_tag=Rv1305;product=Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein);protein_id=CCP44062.1;transl_table=11
AL123456.3	EMBL	gene	1461321	1461836	.	+	.	ID=gene-Rv1306;Name=atpF;gbkey=Gene;gene=atpF;gene_biotype=protein_coding;locus_tag=Rv1306
AL123456.3	EMBL	CDS	1461321	1461836	.	+	0	ID=cds-CCP44063.1;Parent=gene-Rv1306;Dbxref=EnsemblGenomes-Gn:Rv1306,EnsemblGenomes-Tr:CCP44063,GOA:P9WPV5,InterPro:IPR002146,InterPro:IPR028987,NCBI_GP:CCP44063.1;Name=CCP44063.1;Note=Rv1306%2C (MTCY373.26)%2C len: 171 aa. Probable atpF%2CATP synthase B chain%2C highly similar to ATPF_MYCLE P45827 (170 aa)%2C FASTA scores%2C opt: 802%2C E(): 0%2C (79.5%25 identity in 171 aa overlap). subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2Cbeta(3)%2C gamma(1)%2C delta(1)%2C epsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase B chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atpF;locus_tag=Rv1306;product=Probable ATP synthase B chain AtpF;protein_id=CCP44063.1;transl_table=11
AL123456.3	EMBL	gene	1461843	1463183	.	+	.	ID=gene-Rv1307;Name=atpH;gbkey=Gene;gene=atpH;gene_biotype=protein_coding;locus_tag=Rv1307
AL123456.3	EMBL	CDS	1461843	1463183	.	+	0	ID=cds-CCP44064.1;Parent=gene-Rv1307;Dbxref=EnsemblGenomes-Gn:Rv1307,EnsemblGenomes-Tr:CCP44064,GOA:P9WPV3,InterPro:IPR000711,InterPro:IPR002146,InterPro:IPR005864,InterPro:IPR026015,InterPro:IPR028987,NCBI_GP:CCP44064.1;Name=CCP44064.1;Note=Rv1307%2C (MTCY373.27)%2C len: 446 aa. Probable atpH%2CATP synthase delta chain. This protein is much longer than that of other bacterial delta chains%2C the C-terminal region is homologous to delta chains while the N-terminal region is similar to B/B' subunits e.g. ATPD_STRLI|P50008 ATP synthase delta chain from Streptomyces lividans (273 aa)%2CFASTA scores: opt: 505%2C E(): 5.4e-23%2C (35.0%25 identity in 277 aa overlap)%3B and ATPF_HAEIN|P43720 ATP synthase B chain from Haemophilus influenzae (156 aa)%2C FASTA scores: opt: 216%2C E(): 1.2e-06%2C (26.1%25 identity in 153 aa overlap). subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2C beta(3)%2C gamma(1)%2Cdelta(1)%2C epsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase delta chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atpH;locus_tag=Rv1307;product=Probable ATP synthase delta chain AtpH;protein_id=CCP44064.1;transl_table=11
AL123456.3	EMBL	gene	1463228	1464877	.	+	.	ID=gene-Rv1308;Name=atpA;gbkey=Gene;gene=atpA;gene_biotype=protein_coding;locus_tag=Rv1308
AL123456.3	EMBL	CDS	1463228	1464877	.	+	0	ID=cds-CCP44065.1;Parent=gene-Rv1308;Dbxref=EnsemblGenomes-Gn:Rv1308,EnsemblGenomes-Tr:CCP44065,GOA:P9WPU7,InterPro:IPR000194,InterPro:IPR000793,InterPro:IPR004100,InterPro:IPR005294,InterPro:IPR020003,InterPro:IPR023366,InterPro:IPR027417,NCBI_GP:CCP44065.1;Name=CCP44065.1;Note=Rv1308%2C (MTCY373.28)%2C len: 549 aa. Probable atpA%2CATP synthase alpha chain%2C highly similar to ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa)%2C FASTA scores: opt: 3233%2C E(): 0%2C (90.3%25 identity in 547 aa overlap). Contains PS00017 ATP/GTP-binding site motif A%2CPS00152 ATP synthase alpha and beta subunits signature. subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2C beta(3)%2C gamma(1)%2Cdelta(1)%2C epsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase alpha/beta chains family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atpA;inference=protein motif:PROSITE:PS00152;locus_tag=Rv1308;product=Probable ATP synthase alpha chain AtpA;protein_id=CCP44065.1;transl_table=11
AL123456.3	EMBL	gene	1464884	1465801	.	+	.	ID=gene-Rv1309;Name=atpG;gbkey=Gene;gene=atpG;gene_biotype=protein_coding;locus_tag=Rv1309
AL123456.3	EMBL	CDS	1464884	1465801	.	+	0	ID=cds-CCP44066.1;Parent=gene-Rv1309;Dbxref=EnsemblGenomes-Gn:Rv1309,EnsemblGenomes-Tr:CCP44066,GOA:P9WPU9,InterPro:IPR000131,InterPro:IPR023632,InterPro:IPR023633,NCBI_GP:CCP44066.1;Name=CCP44066.1;Note=Rv1309%2C (MTCY373.29)%2C len: 305 aa. Probable atpG%2CATP synthase gamma chain%2C highly similar to ATPG_MYCLE|P45824 ATP synthase gamma chain from Mycobacterium leprae (298 aa)%2C FASTA scores: opt: 1579%2CE():0%2C (83.9%25 identity in 305 aa overlap). Contains PS00153 ATP synthase gamma subunit signature. subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2C beta(3)%2C gamma(1)%2C delta(1)%2Cepsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase gamma chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atpG;inference=protein motif:PROSITE:PS00153;locus_tag=Rv1309;product=Probable ATP synthase gamma chain AtpG;protein_id=CCP44066.1;transl_table=11
AL123456.3	EMBL	gene	1465841	1467301	.	+	.	ID=gene-Rv1310;Name=atpD;gbkey=Gene;gene=atpD;gene_biotype=protein_coding;locus_tag=Rv1310
AL123456.3	EMBL	CDS	1465841	1467301	.	+	0	ID=cds-CCP44067.1;Parent=gene-Rv1310;Dbxref=EnsemblGenomes-Gn:Rv1310,EnsemblGenomes-Tr:CCP44067,GOA:P9WPU5,InterPro:IPR000194,InterPro:IPR000793,InterPro:IPR003593,InterPro:IPR004100,InterPro:IPR005722,InterPro:IPR020003,InterPro:IPR024034,InterPro:IPR027417,NCBI_GP:CCP44067.1;Name=CCP44067.1;Note=Rv1310%2C (MTCY373.30)%2C len: 486 aa. Probable atpD%2CATP synthase beta chain%2C highly similar to ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa)%2C FASTA score: opt: 2916%2C E(): 0%2C (92.6%25 identity in 484 aa overlap). Contains PS00017 ATP/GTP-binding site motif A%2CPS00152 ATP synthase alpha and beta subunits signature. subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2C beta(3)%2C gamma(1)%2Cdelta(1)%2C epsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase alpha/beta chains family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atpD;inference=protein motif:PROSITE:PS00152;locus_tag=Rv1310;product=Probable ATP synthase beta chain AtpD;protein_id=CCP44067.1;transl_table=11
AL123456.3	EMBL	gene	1467315	1467680	.	+	.	ID=gene-Rv1311;Name=atpC;gbkey=Gene;gene=atpC;gene_biotype=protein_coding;locus_tag=Rv1311
AL123456.3	EMBL	CDS	1467315	1467680	.	+	0	ID=cds-CCP44068.1;Parent=gene-Rv1311;Dbxref=EnsemblGenomes-Gn:Rv1311,EnsemblGenomes-Tr:CCP44068,GOA:P9WPV1,InterPro:IPR001469,InterPro:IPR020546,PDB:2LX5,NCBI_GP:CCP44068.1;Name=CCP44068.1;Note=Rv1311%2C (MTCY373.31)%2C len: 121 aa. Probable atpC%2CATP synthase epsilon chain%2C highly similar to ATPE_MYCLE|P45822 Mycobacterium leprae (124 aa)%2C FASTA scores: opt: 682%2C E(): 5.4e-40%2C (87.6%25 identity in 121 aa overlap). subunit: F-type ATPases have 2 components%2C cf(1) - the catalytic core - and cf(0) - the membrane proton channel. cf(1) has five subunits: alpha(3)%2C beta(3)%2Cgamma(1)%2C delta(1)%2C epsilon(1). cf(0) has three main subunits: A%2C B and C. Belongs to the ATPase epsilon chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atpC;locus_tag=Rv1311;product=Probable ATP synthase epsilon chain AtpC;protein_id=CCP44068.1;transl_table=11
AL123456.3	EMBL	gene	1467688	1468131	.	+	.	ID=gene-Rv1312;Name=Rv1312;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1312
AL123456.3	EMBL	CDS	1467688	1468131	.	+	0	ID=cds-CCP44069.1;Parent=gene-Rv1312;Dbxref=EnsemblGenomes-Gn:Rv1312,EnsemblGenomes-Tr:CCP44069,GOA:P9WM29,InterPro:IPR019675,NCBI_GP:CCP44069.1;Name=CCP44069.1;Note=Rv1312%2C (MTCY373.32)%2C len: 147 aa. Conserved hypothetical secreted protein with potential N-terminal signal sequence. Highly similar to P53432|Y02W_MYCLE hypothetical Mycobacterium leprae protein (147 aa)%2C FASTA score: opt: 884%2C E(): 0%2C (88.4%25 identity in 147 aa overlap). N-terminus hydrophobic.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1312;product=Conserved hypothetical secreted protein;protein_id=CCP44069.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1468143	1469651	.	-	.	ID=id-AL123456.3:1468143..1469651;Note=IS1557-2%2C len: 1509 nt. Insertion sequence IS1557.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1557-2
AL123456.3	EMBL	repeat_region	1468143	1468161	.	+	.	ID=id-AL123456.3:1468143..1468161;Note=19 bp inverted repeat%2C GCAGACGCAAAAGCCCCCA%2C at the left end of IS1557;gbkey=repeat_region
AL123456.3	EMBL	gene	1468171	1469505	.	-	.	ID=gene-Rv1313c;Name=Rv1313c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1313c
AL123456.3	EMBL	CDS	1468171	1469505	.	-	0	ID=cds-CCP44070.1;Parent=gene-Rv1313c;Dbxref=EnsemblGenomes-Gn:Rv1313c,EnsemblGenomes-Tr:CCP44070,GOA:P9WKH7,InterPro:IPR002560,InterPro:IPR029261,NCBI_GP:CCP44070.1;Name=CCP44070.1;Note=Rv1313c%2C (MTCY373.33c)%2C len: 444 aa. Possible IS1557 transposase%2C similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 aa)%2C FASTA scores: opt: 767%2C E(): 0%2C (67.3%25 identity in 168 aa overlap)%3B TNPA_BORPA|Q06126 transposase for insertion sequence element IS1001 from Bordetella parapertussis (406 aa)%2C FASTA scores: opt: 254%2C E(): 3.3e-10%2C (24.9%25 identity in 402 aa overlap). Also similar to putative Mycobacterium tuberculosis transposases%2C Rv3798 and Rv0741.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1313c;product=Possible transposase;protein_id=CCP44070.1;transl_table=11
AL123456.3	EMBL	repeat_region	1469633	1469651	.	-	.	ID=id-AL123456.3:1469633..1469651;Note=19 bp inverted repeat%2C GCAGACGCGAAAGCCCCCA%2C at the right end of IS1557. Single base difference at 3-end.;gbkey=repeat_region
AL123456.3	EMBL	gene	1469671	1470252	.	-	.	ID=gene-Rv1314c;Name=Rv1314c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1314c
AL123456.3	EMBL	CDS	1469671	1470252	.	-	0	ID=cds-CCP44071.1;Parent=gene-Rv1314c;Dbxref=EnsemblGenomes-Gn:Rv1314c,EnsemblGenomes-Tr:CCP44071,GOA:P9WP99,InterPro:IPR016030,InterPro:IPR029499,PDB:2G2D,NCBI_GP:CCP44071.1;Name=CCP44071.1;Note=Rv1314c%2C (MTCY373.34c)%2C len: 193 aa. Conserved protein%2C highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa)%2C FASTA score: opt:1019%2C E(): 0%2C (81.2%25 identity in 191 aa overlap). Some similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa protein in dhar-dhat intergenic region (176 aa)%2C FASTA scores: opt: 297%2C E(): 1.6e-13%2C (37.6%25 identity in 178 aa overlap). Also similar to hypothetical protein AE002007|AE002007_3 Deinococcus radiodurans (185 aa)%2C FASTA score: opt: 386%2C E(): 7.7e-19%2C (42.4%25 identity in 172 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1314c;product=Conserved protein;protein_id=CCP44071.1;transl_table=11
AL123456.3	EMBL	gene	1470321	1471577	.	+	.	ID=gene-Rv1315;Name=murA;gbkey=Gene;gene=murA;gene_biotype=protein_coding;locus_tag=Rv1315
AL123456.3	EMBL	CDS	1470321	1471577	.	+	0	ID=cds-CCP44072.1;Parent=gene-Rv1315;Dbxref=EnsemblGenomes-Gn:Rv1315,EnsemblGenomes-Tr:CCP44072,GOA:P9WJM1,InterPro:IPR001986,InterPro:IPR005750,InterPro:IPR013792,NCBI_GP:CCP44072.1;Name=CCP44072.1;Note=Rv1315%2C (MTCY373.35-MTCY149.01)%2C len: 418 aa. Probable murA%2C UDP-N-acetylglucosamine 1-carboxyvinyltransferase (see Belanger %26 Inamine 2000)%2Chighly similar to many e.g. MURA_MYCLE|P45821 (418 aa)%2CFASTA scores: opt: 2495%2C E(): 0%2C (96.2%25 identity in 396 aa overlap). Belongs to the EPSP synthase family. MURA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=murA;locus_tag=Rv1315;product=Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA;protein_id=CCP44072.1;transl_table=11
AL123456.3	EMBL	gene	1471619	1471742	.	+	.	ID=gene-mcr3;Name=mcr3;gbkey=Gene;gene=mcr3;gene_biotype=ncRNA;gene_synonym=mpr7
AL123456.3	EMBL	ncRNA	1471619	1471742	.	+	.	ID=rna-mcr3;Parent=gene-mcr3;Note=mcr3%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped.;gbkey=ncRNA;gene=mcr3;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1471619	1471742	.	+	.	ID=exon-mcr3-1;Parent=rna-mcr3;Note=mcr3%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped.;gbkey=ncRNA;gene=mcr3;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1471846	1473382	.	+	.	ID=gene-rrs;Name=rrs;gbkey=Gene;gene=rrs;gene_biotype=rRNA
AL123456.3	EMBL	rRNA	1471846	1473382	.	+	.	ID=rna-rrs;Parent=gene-rrs;Note=rrs%2C 16s rRNA gene (alternate gene name: rrnS).;gbkey=rRNA;gene=rrs;product=Ribosomal RNA 16S
AL123456.3	EMBL	exon	1471846	1473382	.	+	.	ID=exon-rrs-1;Parent=rna-rrs;Note=rrs%2C 16s rRNA gene (alternate gene name: rrnS).;gbkey=rRNA;gene=rrs;product=Ribosomal RNA 16S
AL123456.3	EMBL	gene	1473658	1476795	.	+	.	ID=gene-rrl;Name=rrl;gbkey=Gene;gene=rrl;gene_biotype=rRNA
AL123456.3	EMBL	rRNA	1473658	1476795	.	+	.	ID=rna-rrl;Parent=gene-rrl;Note=rrl%2C 23S rRNA gene (approximate coordinates).;gbkey=rRNA;gene=rrl;product=Ribosomal RNA 23S
AL123456.3	EMBL	exon	1473658	1476795	.	+	.	ID=exon-rrl-1;Parent=rna-rrl;Note=rrl%2C 23S rRNA gene (approximate coordinates).;gbkey=rRNA;gene=rrl;product=Ribosomal RNA 23S
AL123456.3	EMBL	gene	1476899	1477013	.	+	.	ID=gene-rrf;Name=rrf;gbkey=Gene;gene=rrf;gene_biotype=rRNA
AL123456.3	EMBL	rRNA	1476899	1477013	.	+	.	ID=rna-rrf;Parent=gene-rrf;Note=rrf%2C 5S rRNA gene. Identical to Em_ba:MT5SRR%2C D10035 M.tuberculosis 5S rRNA%2C len: 116.;gbkey=rRNA;gene=rrf;product=Ribosomal RNA 5S
AL123456.3	EMBL	exon	1476899	1477013	.	+	.	ID=exon-rrf-1;Parent=rna-rrf;Note=rrf%2C 5S rRNA gene. Identical to Em_ba:MT5SRR%2C D10035 M.tuberculosis 5S rRNA%2C len: 116.;gbkey=rRNA;gene=rrf;product=Ribosomal RNA 5S
AL123456.3	EMBL	gene	1477134	1477631	.	-	.	ID=gene-Rv1316c;Name=ogt;gbkey=Gene;gene=ogt;gene_biotype=protein_coding;gene_synonym=adaB;locus_tag=Rv1316c
AL123456.3	EMBL	CDS	1477134	1477631	.	-	0	ID=cds-CCP44073.1;Parent=gene-Rv1316c;Dbxref=EnsemblGenomes-Gn:Rv1316c,EnsemblGenomes-Tr:CCP44073,GOA:P9WJW5,InterPro:IPR001497,InterPro:IPR008332,InterPro:IPR011991,InterPro:IPR014048,InterPro:IPR023546,PDB:4BHB,PDB:4BHC,NCBI_GP:CCP44073.1;Name=CCP44073.1;Note=Rv1316c%2C (MTCY130.01c)%2C len: 165 aa. Ogt%2Cmethylated-dna--protein-cysteine methytransferase (see citation below)%2C similar to many e.g. OGT_HAEIN|P44687 Haemophilus influenzae (190 aa)%2C FASTA scores: opt: 405%2CE(): 6.5e-20%2C (41.9%25 identity in 155 aa overlap). Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ogt;inference=protein motif:PROSITE:PS00374;locus_tag=Rv1316c;product=Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase);protein_id=CCP44073.1;transl_table=11
AL123456.3	EMBL	gene	1477628	1479118	.	-	.	ID=gene-Rv1317c;Name=alkA;gbkey=Gene;gene=alkA;gene_biotype=protein_coding;gene_synonym=ada;locus_tag=Rv1317c
AL123456.3	EMBL	CDS	1477628	1479118	.	-	0	ID=cds-CCP44074.1;Parent=gene-Rv1317c;Dbxref=EnsemblGenomes-Gn:Rv1317c,EnsemblGenomes-Tr:CCP44074,GOA:P9WJW3,InterPro:IPR003265,InterPro:IPR003583,InterPro:IPR004026,InterPro:IPR009057,InterPro:IPR010316,InterPro:IPR011257,InterPro:IPR018060,InterPro:IPR018062,InterPro:IPR023170,NCBI_GP:CCP44074.1;Name=CCP44074.1;Note=Rv1317c%2C (MTCY130.02c)%2C len: 496 aa. Probable alkA (alternate gene name: ada)%2C bifunctional regulatory protein (see citation below) and DNA repair enzyme%2C similar to 3MG2_ECOLI|P04395 dna-3-methyladenine glycosidase II from Escherichia coli (282 aa)%2C FASTA scores%2C opt: 437%2C E(): 8.6e-22%2C (32.8%25 identity in 293 aa overlap)%2C also similar to other ada proteins e.g. ADA_SALTY|P26189 Salmonella typhimurium (352 aa)%2C FASTA scores: E(): 5.3e-08%2C (35.9%25 identity in 156 aa overlap). Contains PS00041 Bacterial regulatory proteins%2C araC family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=alkA;inference=protein motif:PROSITE:PS00041;locus_tag=Rv1317c;product=Probable bifunctional regulatory protein and DNA repair enzyme AlkA (regulatory protein of adaptative response) (methylphosphotriester-DNA--protein-cysteine S-methyltransferase);protein_id=CCP44074.1;transl_table=11
AL123456.3	EMBL	gene	1479199	1480824	.	-	.	ID=gene-Rv1318c;Name=Rv1318c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1318c
AL123456.3	EMBL	CDS	1479199	1480824	.	-	0	ID=cds-CCP44075.1;Parent=gene-Rv1318c;Dbxref=EnsemblGenomes-Gn:Rv1318c,EnsemblGenomes-Tr:CCP44075,GOA:P9WQ33,InterPro:IPR001054,InterPro:IPR003660,InterPro:IPR029787,NCBI_GP:CCP44075.1;Name=CCP44075.1;Note=Rv1318c%2C (MTCY130.03c)%2C len: 541 aa. Possible adenylate cyclase. Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa)%2C FASTA scores%2C opt: 270%2C E(): 2.5e-11%2C (28.8%25 identity in 184 aa overlap)%3B similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa)%2C FASTA scores: opt: 2505%2C E(): 0%2C (71.0%25 identity in 534 aa overlap)%2C also similar to Rv1320c|MTCY130.05c (567 aa)%2C FASTA scores%2C opt: 2423%2C E(): 0%2C (68.7%25 identity in 534 aa overlap). N-terminus is hydrophobic. Belongs to adenylyl cyclase class-3 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1318c;product=Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);protein_id=CCP44075.1;transl_table=11
AL123456.3	EMBL	gene	1480894	1482501	.	-	.	ID=gene-Rv1319c;Name=Rv1319c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1319c
AL123456.3	EMBL	CDS	1480894	1482501	.	-	0	ID=cds-CCP44076.1;Parent=gene-Rv1319c;Dbxref=EnsemblGenomes-Gn:Rv1319c,EnsemblGenomes-Tr:CCP44076,GOA:P9WQ31,InterPro:IPR001054,InterPro:IPR003660,InterPro:IPR029787,NCBI_GP:CCP44076.1;Name=CCP44076.1;Note=Rv1319c%2C (MTCY130.04c)%2C len: 535 aa. Possible adenylate cyclase. Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa)%2C FASTA scores: opt: 254%2C E(): 2.4e-10%2C (33.3%25 identity in 144 aa overlap)%3B similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa)%2C FASTA scores: opt: 2505%2C E(): 0%2C (71.0%25 identity in 534 aa overlap)%3B Rv1320c|MTCY130.05c (567 aa)%2C FASTA scores: opt: 2354%2C E(): 0%2C (66.3%25 identity in 534 aa overlap). N-terminus is hydrophobic. Belongs to adenylyl cyclase class-3 family.;gbkey=CDS;locus_tag=Rv1319c;product=Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);protein_id=CCP44076.1;transl_table=11
AL123456.3	EMBL	gene	1482514	1484217	.	-	.	ID=gene-Rv1320c;Name=Rv1320c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1320c
AL123456.3	EMBL	CDS	1482514	1484217	.	-	0	ID=cds-CCP44077.1;Parent=gene-Rv1320c;Dbxref=EnsemblGenomes-Gn:Rv1320c,EnsemblGenomes-Tr:CCP44077,GOA:P9WQ29,InterPro:IPR001054,InterPro:IPR003660,InterPro:IPR029787,NCBI_GP:CCP44077.1;Name=CCP44077.1;Note=Rv1320c%2C (MTCY130.05c)%2C len: 567 aa. Possible adenylate cyclase (see Rindi et al.%2C 1999). Some similarity at the C-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa)%2C FASTA scores: opt: 277%2CE(): 2e-12%2C (34.0%25 identity in 156 aa overlap)%3B similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541 aa)%2C FASTA scores: opt: 2423%2CE(): 0%2C (68.7%25 identity in 534 aa overlap)%3B Rv1319c|MTCY130.04c (535 aa)%2C FASTA scores: opt: 2354%2C E(): 0%2C (66.3%25 identity in 534 aa overlap). N-terminus is hydrophobic. Belongs to adenylyl cyclase class-3 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1320c;product=Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);protein_id=CCP44077.1;transl_table=11
AL123456.3	EMBL	gene	1484279	1484959	.	+	.	ID=gene-Rv1321;Name=Rv1321;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1321
AL123456.3	EMBL	CDS	1484279	1484959	.	+	0	ID=cds-CCP44078.1;Parent=gene-Rv1321;Dbxref=EnsemblGenomes-Gn:Rv1321,EnsemblGenomes-Tr:CCP44078,GOA:P9WIY5,InterPro:IPR002793,NCBI_GP:CCP44078.1;Name=CCP44078.1;Note=Rv1321%2C (MTCY130.06)%2C len: 226 aa. Conserved hypothetical protein. Equivalent to P53524|YD21_MYCLE hypothetical protein from Mycobacterium leprae (201 aa)%2CFASTA scores: opt: 1144%2C E(): 0%2C (87.6%25 identity in 193 aa overlap). Some similarity to hypothetical proteins from other organisms e.g. Y225_METJA|Q57678 Methanococcus jannaschii (263 aa)%2C FASTA scores: E(): 6.5e-05%2C (25.0%25 identity in 212 aa overlap).;gbkey=CDS;locus_tag=Rv1321;product=Conserved hypothetical protein;protein_id=CCP44078.1;transl_table=11
AL123456.3	EMBL	gene	1484982	1485278	.	+	.	ID=gene-Rv1322;Name=Rv1322;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1322
AL123456.3	EMBL	CDS	1484982	1485278	.	+	0	ID=cds-CCP44079.1;Parent=gene-Rv1322;Dbxref=EnsemblGenomes-Gn:Rv1322,EnsemblGenomes-Tr:CCP44079,NCBI_GP:CCP44079.1;Name=CCP44079.1;Note=Rv1322%2C (MTCY130.07)%2C len: 98 aa. Conserved hypothetical protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1322;product=Conserved hypothetical protein;protein_id=CCP44079.1;transl_table=11
AL123456.3	EMBL	gene	1485313	1485771	.	-	.	ID=gene-Rv1322A;Name=Rv1322A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1322A
AL123456.3	EMBL	CDS	1485313	1485771	.	-	0	ID=cds-CCP44080.1;Parent=gene-Rv1322A;Dbxref=EnsemblGenomes-Gn:Rv1322A,EnsemblGenomes-Tr:CCP44080,InterPro:IPR017515,InterPro:IPR029068,UniProtKB/TrEMBL:L7N6B1,NCBI_GP:CCP44080.1;Name=CCP44080.1;Note=Rv1322A%2C len: 152 aa. Conserved protein%2C similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. AL583921_2|ML1157 from M. leprae strain tn (155 aa)%2C FASTA scores: opt: 771%2C E(): 5.1e-43%2C (75.3%25 identity in 154 aa overlap)%3B and AL137242_2 from Streptomyces coelicolor (146 aa)%2C FASTA scores: opt: 404%2CE(): 2e-19%2C (43.165%25 identity in 139 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1322A;product=Conserved protein;protein_id=CCP44080.1;transl_table=11
AL123456.3	EMBL	gene	1485862	1487031	.	+	.	ID=gene-Rv1323;Name=fadA4;gbkey=Gene;gene=fadA4;gene_biotype=protein_coding;locus_tag=Rv1323
AL123456.3	EMBL	CDS	1485862	1487031	.	+	0	ID=cds-CCP44081.1;Parent=gene-Rv1323;Dbxref=EnsemblGenomes-Gn:Rv1323,EnsemblGenomes-Tr:CCP44081,GOA:P9WG69,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020610,InterPro:IPR020613,InterPro:IPR020615,InterPro:IPR020616,InterPro:IPR020617,NCBI_GP:CCP44081.1;Name=CCP44081.1;Note=Rv1323%2C (MTCY130.08)%2C len: 389 aa. Probable fadA4%2Cacetyl-CoA acetyltransferase%2C equivalent to THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase from Mycobacterium leprae (393 aa)%2C FASTA scores: opt: 2218%2C E(): 0%2C (87.0%25 identity in 392 aa overlap). Also highly similar to others e.g. CAB70629.1|AL137242 probable acetoacetyl-CoA thiolase from Streptomyces coelicolor (401 aa)%3B T51772 acetyl-CoA C-acetyltransferase [validated] from Alcaligenes latus (392 aa)%3B etc. Some homologies indicate ATA start codon. Contains PS00098 Thiolases acyl-enzyme intermediate signature%2C PS00737 Thiolases signature 2%2C and PS00099 Thiolases active site. Belongs to the thiolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadA4;inference=protein motif:PROSITE:PS00737;locus_tag=Rv1323;product=Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase);protein_id=CCP44081.1;transl_table=11
AL123456.3	EMBL	gene	1487161	1488075	.	+	.	ID=gene-Rv1324;Name=Rv1324;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1324
AL123456.3	EMBL	CDS	1487161	1488075	.	+	0	ID=cds-CCP44082.1;Parent=gene-Rv1324;Dbxref=EnsemblGenomes-Gn:Rv1324,EnsemblGenomes-Tr:CCP44082,GOA:P9WG61,InterPro:IPR005746,InterPro:IPR011990,InterPro:IPR012336,InterPro:IPR013766,NCBI_GP:CCP44082.1;Name=CCP44082.1;Note=Rv1324%2C (MTCY130.09)%2C len: 304 aa. Possible thioredoxin%2C similar to several e.g. U00014|Q49716 TRXA from Mycobacterium leprae (255 aa)%2C FASTA scores: opt: 1014%2C E(): 0%2C (69.7%25 identity in 228 aa overlap)%3B THIO_RHOSH|P08058 TrxA from Rhodobacter sphaeroides (105 aa)%2C FASTA scores: opt 196%2C E(): 1.9e-06%2C (33.0%25 identity in 103 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00339;locus_tag=Rv1324;product=Possible thioredoxin;protein_id=CCP44082.1;transl_table=11
AL123456.3	EMBL	gene	1488154	1489965	.	-	.	ID=gene-Rv1325c;Name=PE_PGRS24;gbkey=Gene;gene=PE_PGRS24;gene_biotype=protein_coding;locus_tag=Rv1325c
AL123456.3	EMBL	CDS	1488154	1489965	.	-	0	ID=cds-CCP44083.1;Parent=gene-Rv1325c;Dbxref=EnsemblGenomes-Gn:Rv1325c,EnsemblGenomes-Tr:CCP44083,InterPro:IPR000084,NCBI_GP:CCP44083.1;Name=CCP44083.1;Note=Rv1325c%2C (MTCY130.10c)%2C len: 603 aa. PE_PGRS24%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of ala-%2C gly-rich proteins (see Brennan %26 Delogu 2002)%2C similar to many e.g. YQ04_MYCTU|P71933 hypothetical 63.1 kDa glycine-rich protein (778 aa)%2C FASTA scores: E(): 0%2C (52.3%25 identity in 724 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS24;locus_tag=Rv1325c;product=PE-PGRS family protein PE_PGRS24;protein_id=CCP44083.1;transl_table=11
AL123456.3	EMBL	gene	1490117	1492312	.	-	.	ID=gene-Rv1326c;Name=glgB;gbkey=Gene;gene=glgB;gene_biotype=protein_coding;locus_tag=Rv1326c
AL123456.3	EMBL	CDS	1490117	1492312	.	-	0	ID=cds-CCP44084.1;Parent=gene-Rv1326c;Dbxref=EnsemblGenomes-Gn:Rv1326c,EnsemblGenomes-Tr:CCP44084,GOA:P9WN45,InterPro:IPR004193,InterPro:IPR006047,InterPro:IPR006048,InterPro:IPR006407,InterPro:IPR013780,InterPro:IPR013781,InterPro:IPR013783,InterPro:IPR014756,InterPro:IPR015902,InterPro:IPR017853,PDB:3K1D,NCBI_GP:CCP44084.1;Name=CCP44084.1;Note=Rv1326c%2C (MTCY130.11c)%2C len: 731 aa. glgB%2C1%2C4-alpha-glucan branching enzyme%2C similar to others e.g. GLGB_ECOLI|P07762 Escherichia coli (728 aa)%2C FASTA scores: opt: 2330%2C E(): 0%2C (48.7%25 identity in 719 aa overlap). Similar to other Mycobacterium tuberculosis putative alpha-glucan branching enzymes Rv1562c%2C Rv1563c. Belongs to family 13 of glycosyl hydrolases%2C also known as the alpha-amylase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glgB;locus_tag=Rv1326c;product=1%2C4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme);protein_id=CCP44084.1;transl_table=11
AL123456.3	EMBL	gene	1492320	1494425	.	-	.	ID=gene-Rv1327c;Name=glgE;gbkey=Gene;gene=glgE;gene_biotype=protein_coding;locus_tag=Rv1327c
AL123456.3	EMBL	CDS	1492320	1494425	.	-	0	ID=cds-CCP44085.1;Parent=gene-Rv1327c;Dbxref=EnsemblGenomes-Gn:Rv1327c,EnsemblGenomes-Tr:CCP44085,GOA:P9WQ17,InterPro:IPR006047,InterPro:IPR013781,InterPro:IPR015902,InterPro:IPR017853,InterPro:IPR021828,InterPro:IPR026585,NCBI_GP:CCP44085.1;Name=CCP44085.1;Note=Rv1327c%2C (MTCY130.12c)%2C len: 701 aa. Probable glgE%2Cglucanase%2C similar to AF172946|AF172946_2 putative glucanase GlgE from Mycobacterium smegmatis (697 aa)%2C FASTA scores: opt: 3816%2C E(): 0%2C (78.5%25 identity in 692 aa overlap). Similar to putative alpha-amylases e.g. Q9L1K2 Streptomyces coelicolor (675 aa)%2C FASTA scores: opt: 2243%2CE(): 7.4e-132%2C (54.2%25 identity in 684 aa overlap). Start changed since original submission (-36) based on similarity to GlgE of Mycobacterium smegmatis%3B previous start at position 1494531.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glgE;locus_tag=Rv1327c;product=Probable glucanase GlgE;protein_id=CCP44085.1;transl_table=11
AL123456.3	EMBL	gene	1494564	1497155	.	+	.	ID=gene-Rv1328;Name=glgP;gbkey=Gene;gene=glgP;gene_biotype=protein_coding;locus_tag=Rv1328
AL123456.3	EMBL	CDS	1494564	1497155	.	+	0	ID=cds-CCP44086.1;Parent=gene-Rv1328;Dbxref=EnsemblGenomes-Gn:Rv1328,EnsemblGenomes-Tr:CCP44086,GOA:P9WMW1,InterPro:IPR000811,InterPro:IPR011834,InterPro:IPR024517,NCBI_GP:CCP44086.1;Name=CCP44086.1;Note=Rv1328%2C (MTCY130.13)%2C len: 863 aa. Probable glgP%2Cglycogen phosphorylase%2C similar to many e.g. PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus influenzae (821 aa)%2C FASTA scores: E(): 6.9e-08%2C (25.6%25 identity in 675 aa overlap). Belongs to the glycogen phosphorylase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glgP;locus_tag=Rv1328;product=Probable glycogen phosphorylase GlgP;protein_id=CCP44086.1;transl_table=11
AL123456.3	EMBL	gene	1497195	1499189	.	-	.	ID=gene-Rv1329c;Name=dinG;gbkey=Gene;gene=dinG;gene_biotype=protein_coding;locus_tag=Rv1329c
AL123456.3	EMBL	CDS	1497195	1499189	.	-	0	ID=cds-CCP44087.1;Parent=gene-Rv1329c;Dbxref=EnsemblGenomes-Gn:Rv1329c,EnsemblGenomes-Tr:CCP44087,GOA:P9WMR5,InterPro:IPR006555,InterPro:IPR011545,InterPro:IPR014001,InterPro:IPR014013,InterPro:IPR027417,NCBI_GP:CCP44087.1;Name=CCP44087.1;Note=Rv1329c%2C (MTCY130.14c)%2C len: 664 aa. Probable dinG%2CATP-dependent helicase (see citation below)%2C similar to several e.g. DING_HAEIN|P44680 probable ATP-dependent helicase ding from Haemophilus influenzae (640 aa)%2C FASTA scores: opt: 685%2C E(): 2.3e-38%2C (32.8%25 identity in 644 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dinG;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1329c;product=Probable ATP-dependent helicase DinG;protein_id=CCP44087.1;transl_table=11
AL123456.3	EMBL	gene	1499213	1500559	.	-	.	ID=gene-Rv1330c;Name=pncB1;gbkey=Gene;gene=pncB1;gene_biotype=protein_coding;locus_tag=Rv1330c
AL123456.3	EMBL	CDS	1499213	1500559	.	-	0	ID=cds-CCP44088.1;Parent=gene-Rv1330c;Dbxref=EnsemblGenomes-Gn:Rv1330c,EnsemblGenomes-Tr:CCP44088,GOA:P9WJI9,InterPro:IPR002638,InterPro:IPR006405,InterPro:IPR007229,NCBI_GP:CCP44088.1;Name=CCP44088.1;Note=Rv1330c%2C (MTCY130.15c)%2C len: 448 aa. PncB1%2Cnicotinic acid phosphoribosyltransferase (See Boshoff et al.%2C 2008). Similar to e.g. O32090 YUEK protein from Bacillus subtilis (490 aa)%2C FASTA scores: E(): 8.6e-22%2C(37.9%25 identity in 369 aa overlap). Also similar to Mycobacterium tuberculosis Rv0573c|MTV039.11c (38.0%25 identity in 437 aa overlap). Start changed since original submission based on similarity%3B previous start at position 1500740 (-61 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pncB1;locus_tag=Rv1330c;product=Nicotinic acid phosphoribosyltransferase PncB1;protein_id=CCP44088.1;transl_table=11
AL123456.3	EMBL	gene	1500661	1500966	.	+	.	ID=gene-Rv1331;Name=Rv1331;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1331
AL123456.3	EMBL	CDS	1500661	1500966	.	+	0	ID=cds-CCP44089.1;Parent=gene-Rv1331;Dbxref=EnsemblGenomes-Gn:Rv1331,EnsemblGenomes-Tr:CCP44089,GOA:P9WPC1,InterPro:IPR003769,InterPro:IPR014719,InterPro:IPR022935,NCBI_GP:CCP44089.1;Name=CCP44089.1;Note=Rv1331%2C (MTCY130.16)%2C len: 101 aa. Conserved hypothetical protein%2C highly similar to U00014|ML014 B1549_C2_207 from Mycobacterium leprae (94 aa)%2C FASTA scores: opt: 573%2C E(): 2.9e-40%2C (90.3%25 identity in 93 aa overlap). Similar to AL096852|SCE19A_16 hypothetical protein from Streptomyces coelicolor (105 aa)%2C FASTA scores: opt: 377%2C E(): 2.9e-22%2C (60.0%25 identity in 105 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1331;product=Conserved hypothetical protein;protein_id=CCP44089.1;transl_table=11
AL123456.3	EMBL	gene	1500926	1501582	.	+	.	ID=gene-Rv1332;Name=Rv1332;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1332
AL123456.3	EMBL	CDS	1500926	1501582	.	+	0	ID=cds-CCP44090.1;Parent=gene-Rv1332;Dbxref=EnsemblGenomes-Gn:Rv1332,EnsemblGenomes-Tr:CCP44090,InterPro:IPR018561,NCBI_GP:CCP44090.1;Name=CCP44090.1;Note=Rv1332%2C (MTCY130.17)%2C len: 218 aa. Possible regulatory protein%2C high similarity to ML014|U00014 M. leprae B1549_C3_236 (222 aa)%2C FASTA scores: opt: 1158%2C E(): 0%2C (75.6%25 identity in 221 aa overlap). Helix turn helix motif fram aa 8-29 (+3.03 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1332;product=Probable transcriptional regulatory protein;protein_id=CCP44090.1;transl_table=11
AL123456.3	EMBL	gene	1501599	1502633	.	+	.	ID=gene-Rv1333;Name=Rv1333;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1333
AL123456.3	EMBL	CDS	1501599	1502633	.	+	0	ID=cds-CCP44091.1;Parent=gene-Rv1333;Dbxref=EnsemblGenomes-Gn:Rv1333,EnsemblGenomes-Tr:CCP44091,GOA:P9WM23,InterPro:IPR005321,InterPro:IPR016117,NCBI_GP:CCP44091.1;Name=CCP44091.1;Note=Rv1333%2C (MTCY130.18)%2C len: 344 aa. Possible hydrolase%2C similar to Q57326|D26094 endo-type 6-aminohexanoate oligomer hydrolase (355 aa)%2C fasta scores: E(): 1.4e-10%2C (31.9%25 identity in 339 aa overlap). Equivalent to P53425|YD33_MYCLE hypothetical 36.1 KD protein B154 Mycobacterium leprae (362 aa)%2C FASTA scores: opt: 1735%2C E(): 0%2C (76.7%25 identity in 352 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1333;product=Probable hydrolase;protein_id=CCP44091.1;transl_table=11
AL123456.3	EMBL	gene	1502641	1503081	.	+	.	ID=gene-Rv1334;Name=mec;gbkey=Gene;gene=mec;gene_biotype=protein_coding;locus_tag=Rv1334
AL123456.3	EMBL	CDS	1502641	1503081	.	+	0	ID=cds-CCP44092.1;Parent=gene-Rv1334;Dbxref=EnsemblGenomes-Gn:Rv1334,EnsemblGenomes-Tr:CCP44092,GOA:P9WHS1,InterPro:IPR000555,NCBI_GP:CCP44092.1;Name=CCP44092.1;Note=Rv1334%2C (MTCY130.19)%2C len: 146 aa. Possible mec%2Chydrolase (See Burns et al.%2C 2005)%2C similar to AL096852|SCE19A_13 hypothetical protein from Streptomyces coelicolor (140 aa)%2C Fasta scores: opt: 579%2C E(): 0%2C (65.0%25 identity in 140 aa overlap)%3B and Q54330|M29166 MEC+ from Streptomyces kasugaensis (115 aa)%2C FASTA scores%3B E(): 7.6e-33%2C (56.9%25 identity in 109 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mec;locus_tag=Rv1334;product=Possible hydrolase;protein_id=CCP44092.1;transl_table=11
AL123456.3	EMBL	gene	1503103	1503384	.	+	.	ID=gene-Rv1335;Name=cysO;gbkey=Gene;gene=cysO;gene_biotype=protein_coding;gene_synonym=cfp10A;locus_tag=Rv1335
AL123456.3	EMBL	CDS	1503103	1503384	.	+	0	ID=cds-CCP44093.1;Parent=gene-Rv1335;Dbxref=EnsemblGenomes-Gn:Rv1335,EnsemblGenomes-Tr:CCP44093,GOA:P9WP33,InterPro:IPR003749,InterPro:IPR012675,InterPro:IPR016155,PDB:3DWG,PDB:3DWM,NCBI_GP:CCP44093.1;Name=CCP44093.1;Note=Rv1335%2C (MT1376.1%2C MTCY130.20)%2C len: 93 aa. CysO%2Csulfur carrier protein (See Burns et al.%2C 2005). Note that previously known as cfp10A. Similar to hypothetical proteins from other organisms e.g. P74060|D90911 Synechocystis (109 aa)%2C FASTA scores: E(): 2.3e-20%2C (49.5%25 identity in 93 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysO;locus_tag=Rv1335;product=Sulfur carrier protein CysO;protein_id=CCP44093.1;transl_table=11
AL123456.3	EMBL	gene	1503394	1504365	.	+	.	ID=gene-Rv1336;Name=cysM;gbkey=Gene;gene=cysM;gene_biotype=protein_coding;locus_tag=Rv1336
AL123456.3	EMBL	CDS	1503394	1504365	.	+	0	ID=cds-CCP44094.1;Parent=gene-Rv1336;Dbxref=EnsemblGenomes-Gn:Rv1336,EnsemblGenomes-Tr:CCP44094,GOA:P9WP53,InterPro:IPR001216,InterPro:IPR001926,InterPro:IPR005856,PDB:3DKI,PDB:3DWG,PDB:3DWI,PDB:3FGP,NCBI_GP:CCP44094.1;Name=CCP44094.1;Note=Rv1336%2C (MTCY130.21)%2C len: 323 aa. cysM%2C cysteine synthase B%2C similar to many e.g. CYSM_ECOLI|P16703 Escherichia coli (303 aa)%2C FASTA scores: opt: 720%2C E(): 4.6e-40%2C (41.1%25 identity in 302 aa overlap). Also similar to other Mycobacterium tuberculosis cysteine synthase subunits e.g. Rv1077%2C Rv2334%2C Rv0848%2C etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. Belongs to the cysteine synthase/cystathionine beta-synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysM;inference=protein motif:PROSITE:PS00901;locus_tag=Rv1336;product=Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B);protein_id=CCP44094.1;transl_table=11
AL123456.3	EMBL	gene	1504356	1505078	.	+	.	ID=gene-Rv1337;Name=Rv1337;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1337
AL123456.3	EMBL	CDS	1504356	1505078	.	+	0	ID=cds-CCP44095.1;Parent=gene-Rv1337;Dbxref=EnsemblGenomes-Gn:Rv1337,EnsemblGenomes-Tr:CCP44095,GOA:P9WM21,InterPro:IPR002610,InterPro:IPR022764,NCBI_GP:CCP44095.1;Name=CCP44095.1;Note=Rv1337%2C (MTCY130.22)%2C len: 240 aa. Probable integral membrane protein. Highly similar to P53426 hypothetical protein B1549_C3_240 from M.leprae (251)%3B and P74553|D90916 hypothetical protein from Synechocystis sp. (198 aa)%2C FASTA scores: E(): 2.3e-25%2C (43.6%25 identity in 181 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1337;product=Probable integral membrane protein;protein_id=CCP44095.1;transl_table=11
AL123456.3	EMBL	gene	1505075	1505890	.	+	.	ID=gene-Rv1338;Name=murI;gbkey=Gene;gene=murI;gene_biotype=protein_coding;locus_tag=Rv1338
AL123456.3	EMBL	CDS	1505075	1505890	.	+	0	ID=cds-CCP44096.1;Parent=gene-Rv1338;Dbxref=EnsemblGenomes-Gn:Rv1338,EnsemblGenomes-Tr:CCP44096,GOA:P9WPW9,InterPro:IPR001920,InterPro:IPR004391,InterPro:IPR015942,InterPro:IPR018187,NCBI_GP:CCP44096.1;Name=CCP44096.1;Note=Rv1338%2C (MTCY130.23)%2C len: 271 aa. Probable murI%2Cglutamate racemase%2C highly similar to many e.g. MURI_MYCLE|P46705 (272 aa)%2C FASTA scores: opt: 1559%2C E(): 0%2C (88.9%25 identity in 271 aa overlap). Contains PS00924 Aspartate and glutamate racemases signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=murI;inference=protein motif:PROSITE:PS00924;locus_tag=Rv1338;product=Probable glutamate racemase MurI;protein_id=CCP44096.1;transl_table=11
AL123456.3	EMBL	gene	1505917	1506738	.	+	.	ID=gene-Rv1339;Name=Rv1339;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1339
AL123456.3	EMBL	CDS	1505917	1506738	.	+	0	ID=cds-CCP44097.1;Parent=gene-Rv1339;Dbxref=EnsemblGenomes-Gn:Rv1339,EnsemblGenomes-Tr:CCP44097,GOA:P9WGC1,InterPro:IPR001279,NCBI_GP:CCP44097.1;Name=CCP44097.1;Note=Rv1339%2C (MTCY130.24)%2C len: 273 aa. Conserved protein%2C highly similar to Y211_MYCLE|P50474 hypothetical protein b1549_c2_211 from Mycobacterium leprae (284 aa)%2CFASTA scores: opt: 1672%2C E(): 0%2C (86.2%25 identity in 276 aa overlap). Also similar to AL096852|SCE19A.08 hypothetical protein from Streptomyces coelicolor (250 aa)%2C FASTA scores: opt: 630%2C E(): 0%2C (42.2%25 identity in 256 aa overlap). Similar to M. tuberculosis hypothetical proteins Rv3796%2C Rv2407. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1339;product=Conserved protein;protein_id=CCP44097.1;transl_table=11
AL123456.3	EMBL	gene	1506755	1507534	.	+	.	ID=gene-Rv1340;Name=rphA;gbkey=Gene;gene=rphA;gene_biotype=protein_coding;locus_tag=Rv1340
AL123456.3	EMBL	CDS	1506755	1507534	.	+	0	ID=cds-CCP44098.1;Parent=gene-Rv1340;Dbxref=EnsemblGenomes-Gn:Rv1340,EnsemblGenomes-Tr:CCP44098,GOA:P9WGZ7,InterPro:IPR001247,InterPro:IPR002381,InterPro:IPR015847,InterPro:IPR018336,InterPro:IPR020568,InterPro:IPR027408,PDB:3B4T,NCBI_GP:CCP44098.1;Name=CCP44098.1;Note=Rv1340%2C (MTCY130.25)%2C len: 259 aa. Probable rphA%2CRibonuclease ph%2C highly similar to others e.g. RNPH_MYCLE|P37939 Mycobacterium leprae (259 aa)%2C FASTA scores: opt: 1524%2C E(): 0%2C (88.8%25 identity in 259 aa overlap). Belongs to the RNASE PH family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rphA;locus_tag=Rv1340;product=Probable ribonuclease RphA (RNase PH) (tRNA nucleotidyltransferase);protein_id=CCP44098.1;transl_table=11
AL123456.3	EMBL	repeat_region	1507531	1507581	.	+	.	ID=id-AL123456.3:1507531..1507581;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	1507573	1508187	.	+	.	ID=gene-Rv1341;Name=Rv1341;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1341
AL123456.3	EMBL	CDS	1507573	1508187	.	+	0	ID=cds-CCP44099.1;Parent=gene-Rv1341;Dbxref=EnsemblGenomes-Gn:Rv1341,EnsemblGenomes-Tr:CCP44099,GOA:P9WMR7,InterPro:IPR002637,InterPro:IPR020922,InterPro:IPR029001,NCBI_GP:CCP44099.1;Name=CCP44099.1;Note=Rv1341%2C (MTCY130.26)%2C len: 204 aa. Conserved protein%2C some similarity to P52061|YGGV_ECOLI hypothetical protein yggV (197 aa)%2C FASTA scores: opt: 521%2C E(): 7.9e-27%2C (46.0%25 identity in 200 aa overlap). Equivalent to ML014|U00014 hypothetical protein B1549_C2_213 from Mycobacterium leprae (285 aa)%2C FASTA scores: opt: 1073%2CE(): 0%2C (83.0%25 identity in 206 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1341;product=Conserved protein;protein_id=CCP44099.1;transl_table=11
AL123456.3	EMBL	gene	1508184	1508546	.	-	.	ID=gene-Rv1342c;Name=Rv1342c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1342c
AL123456.3	EMBL	CDS	1508184	1508546	.	-	0	ID=cds-CCP44100.1;Parent=gene-Rv1342c;Dbxref=EnsemblGenomes-Gn:Rv1342c,EnsemblGenomes-Tr:CCP44100,GOA:P9WM19,InterPro:IPR023845,NCBI_GP:CCP44100.1;Name=CCP44100.1;Note=Rv1342c%2C (MTCY02B10.06c)%2C len: 120 aa. Conserved membrane protein. Highly similar to G466926|P54133 hypothetical protein B1549_F2_59 from Mycobacterium leprae (119 aa)%2C FASTA scores%2C opt: 544%2C E(): 1.9e-29%2C (68.3 %25 identity in 120 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1342c;product=Conserved membrane protein;protein_id=CCP44100.1;transl_table=11
AL123456.3	EMBL	gene	1508543	1508923	.	-	.	ID=gene-Rv1343c;Name=lprD;gbkey=Gene;gene=lprD;gene_biotype=protein_coding;locus_tag=Rv1343c
AL123456.3	EMBL	CDS	1508543	1508923	.	-	0	ID=cds-CCP44101.1;Parent=gene-Rv1343c;Dbxref=EnsemblGenomes-Gn:Rv1343c,EnsemblGenomes-Tr:CCP44101,GOA:P9WK51,NCBI_GP:CCP44101.1;Name=CCP44101.1;Note=Rv1343c%2C (MTCY02B10.07c)%2C len: 126 aa. Probable lprD%2C conserved lipoprotein%2C highly similar to G466928 Mycobacterium leprae protein B1549_F3_106 (126 aa)%2C FASTA scores%2C opt: 704%2C E(): 7.5e-36%2C (78.4 %25 identity in 125 aa overlap). Has N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprD;locus_tag=Rv1343c;product=Probable conserved lipoprotein LprD;protein_id=CCP44101.1;transl_table=11
AL123456.3	EMBL	gene	1508968	1509288	.	+	.	ID=gene-Rv1344;Name=mbtL;gbkey=Gene;gene=mbtL;gene_biotype=protein_coding;locus_tag=Rv1344
AL123456.3	EMBL	CDS	1508968	1509288	.	+	0	ID=cds-CCP44102.1;Parent=gene-Rv1344;Dbxref=EnsemblGenomes-Gn:Rv1344,EnsemblGenomes-Tr:CCP44102,GOA:P9WQF1,InterPro:IPR009081,NCBI_GP:CCP44102.1;Name=CCP44102.1;Note=Rv1344%2C (MTCY02B10.08)%2C len: 106 aa. mbtL%2C acyl carrier protein%2C similar to others e.g. ACP_RHIME|P19372 Rhizobium meliloti (77 aa)%2C FASTA scores: opt: 117%2C E(): 0.03%2C (29.9%25 identity in 67 aa overlap) and ACP_SYNY3|P20804 acyl carrier protein (acp) from Synechocystis sp (77 aa)%2C FASTA scores: E(): 7.1e-05%2C(34.8%25 identity in 66 aa overlap). Also similar to Rv2244 and Rv0033 from Mycobacterium tuberculosis. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=mbtL;locus_tag=Rv1344;product=Acyl carrier protein (ACP) MbtL;protein_id=CCP44102.1;transl_table=11
AL123456.3	EMBL	gene	1509281	1510846	.	+	.	ID=gene-Rv1345;Name=mbtM;gbkey=Gene;gene=mbtM;gene_biotype=protein_coding;gene_synonym=fadD33;locus_tag=Rv1345
AL123456.3	EMBL	CDS	1509281	1510846	.	+	0	ID=cds-CCP44103.1;Parent=gene-Rv1345;Dbxref=EnsemblGenomes-Gn:Rv1345,EnsemblGenomes-Tr:CCP44103,GOA:P9WQ41,InterPro:IPR000873,InterPro:IPR020845,NCBI_GP:CCP44103.1;Name=CCP44103.1;Note=Rv1345%2C (MTCY02B10.09)%2C len: 521 aa. Probable mbtM%2Cfatty acyl-AMP ligase. Similar to N-terminus of T34918 polyketide synthase from Streptomyces coelicolor (2297 aa)%3B and PKSJ_BACSU|P40806 putative polyketide biosynthesis protein from Bacillus subtilis (557 aa)%2C FASTA scores: opt: 537%2C E(): 8.2e-27%2C (27.1%25 identity in 468 aa overlap). Also similar to other proteins from Mycobacterium tuberculosis eg Rv1013|MTCI237.30|MTCY10G2.36c|pks16 putative polyketide synthase (544 aa)%3B etc. Note that previously known as fadD33.;gbkey=CDS;gene=mbtM;locus_tag=Rv1345;product=Probable fatty acyl-AMP ligase MbtM;protein_id=CCP44103.1;transl_table=11
AL123456.3	EMBL	gene	1510846	1512006	.	+	.	ID=gene-Rv1346;Name=mbtN;gbkey=Gene;gene=mbtN;gene_biotype=protein_coding;gene_synonym=fadE14;locus_tag=Rv1346
AL123456.3	EMBL	CDS	1510846	1512006	.	+	0	ID=cds-CCP44104.1;Parent=gene-Rv1346;Dbxref=EnsemblGenomes-Gn:Rv1346,EnsemblGenomes-Tr:CCP44104,GOA:P9WQF9,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,NCBI_GP:CCP44104.1;Name=CCP44104.1;Note=Rv1346%2C (MTCY02B10.10)%2C len: 386 aa. mbtN%2C acyl-CoA dehydrogenase%2C similar to many e.g. NP_251579.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (386 aa)%3B NP_036951.1|NM_012819|ACDL_RAT|P15650 acyl Coenzyme A dehydrogenase (long chain) from Rattus norvegicus (430 aa)%2C FASTA scores: opt: 414%2C E(): 1.2e-18%2C(26.1%25 identity in 376 aa overlap)%3B etc. Note that previously known as fadE14.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtN;locus_tag=Rv1346;product=Acyl-CoA dehydrogenase MbtN;protein_id=CCP44104.1;transl_table=11
AL123456.3	EMBL	gene	1511973	1512605	.	-	.	ID=gene-Rv1347c;Name=mbtK;gbkey=Gene;gene=mbtK;gene_biotype=protein_coding;locus_tag=Rv1347c
AL123456.3	EMBL	CDS	1511973	1512605	.	-	0	ID=cds-CCP44105.1;Parent=gene-Rv1347c;Dbxref=EnsemblGenomes-Gn:Rv1347c,EnsemblGenomes-Tr:CCP44105,GOA:P9WK15,InterPro:IPR016181,InterPro:IPR019432,PDB:1YK3,NCBI_GP:CCP44105.1;Name=CCP44105.1;Note=Rv1347c%2C (MTCY02B10.11c)%2C len: 210 aa. MbtK%2C lysine N-acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Some similarity to the C-terminus of malonyl-coenzyme A carboxylases e.g. G545170 malonyl-coenzyme A carboxylase (417 aa)%2C FASTA scores: opt: 392%2C E(): 4.9 e-20%2C (35.6%25 identity in 174 aa overlap).;gbkey=CDS;gene=mbtK;locus_tag=Rv1347c;product=Lysine N-acetyltransferase MbtK;protein_id=CCP44105.1;transl_table=11
AL123456.3	EMBL	gene	1512728	1512811	.	+	.	ID=gene-leuW;Name=leuW;gbkey=Gene;gene=leuW;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1512728	1512811	.	+	.	ID=rna-leuW;Parent=gene-leuW;Note=codon recognized: CUA%3B leuW%2C tRNA-Leu%2C anticodon tag%2C length %3D 84;anticodon=(pos:1512762..1512764);gbkey=tRNA;gene=leuW;product=tRNA-Leu
AL123456.3	EMBL	exon	1512728	1512811	.	+	.	ID=exon-leuW-1;Parent=rna-leuW;Note=codon recognized: CUA%3B leuW%2C tRNA-Leu%2C anticodon tag%2C length %3D 84;anticodon=(pos:1512762..1512764);gbkey=tRNA;gene=leuW;product=tRNA-Leu
AL123456.3	EMBL	gene	1513047	1515626	.	+	.	ID=gene-Rv1348;Name=irtA;gbkey=Gene;gene=irtA;gene_biotype=protein_coding;locus_tag=Rv1348
AL123456.3	EMBL	CDS	1513047	1515626	.	+	0	ID=cds-CCP44106.1;Parent=gene-Rv1348;Dbxref=EnsemblGenomes-Gn:Rv1348,EnsemblGenomes-Tr:CCP44106,GOA:P9WQJ9,InterPro:IPR001140,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR007037,InterPro:IPR011527,InterPro:IPR013113,InterPro:IPR017871,InterPro:IPR017927,InterPro:IPR017938,InterPro:IPR027417,NCBI_GP:CCP44106.1;Name=CCP44106.1;Note=Rv1348%2C (MTCY02B10.12)%2C len: 859 aa. IrtA%2Ciron-regulated transporter. Probable transmembrane protein%2Csimilar to HMT1_SCHPO|Q02592 heavy metal tolerance protein precursor from Schizosaccharomyces pombe (830 aa)%2C FASTA scores: opt: 806%2C E(): 5.1e-39%2C (32.9%25 identity in 504 aa overlap)%3B etc. Also similar to MTCY02B10.13 from Mycobacterium tuberculosis%2C FASTA score: (31.9%25 identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters). Cofactor: FAD;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=irtA;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1348;product=Iron-regulated transporter IrtA;protein_id=CCP44106.1;transl_table=11
AL123456.3	EMBL	gene	1515623	1517362	.	+	.	ID=gene-Rv1349;Name=irtB;gbkey=Gene;gene=irtB;gene_biotype=protein_coding;locus_tag=Rv1349
AL123456.3	EMBL	CDS	1515623	1517362	.	+	0	ID=cds-CCP44107.1;Parent=gene-Rv1349;Dbxref=EnsemblGenomes-Gn:Rv1349,EnsemblGenomes-Tr:CCP44107,GOA:P9WQJ7,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR011527,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP44107.1;Name=CCP44107.1;Note=Rv1349%2C (MTCY02B10.13)%2C len: 579 aa. IrtB%2Ciron-regulated transporter. Probable transmembrane protein%2Cmost similar to YWJA_BACSU|P45861 hypothetical ABC transporter from Bacillus subtilis (575 aa)%2C FASTA scores: opt: 721%2C E(): 1.8e-35%2C (28.9%25 identity in 567 aa overlap)%3B etc. Also similar to MTCY02B10.12 from Mycobacterium tuberculosis%2C FASTA score: (31.9%25 identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=irtB;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1349;product=Iron-regulated transporter IrtB;protein_id=CCP44107.1;transl_table=11
AL123456.3	EMBL	gene	1517491	1518234	.	+	.	ID=gene-Rv1350;Name=fabG2;gbkey=Gene;gene=fabG2;gene_biotype=protein_coding;locus_tag=Rv1350
AL123456.3	EMBL	CDS	1517491	1518234	.	+	0	ID=cds-CCP44108.1;Parent=gene-Rv1350;Dbxref=EnsemblGenomes-Gn:Rv1350,EnsemblGenomes-Tr:CCP44108,GOA:P9WGR9,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP44108.1;Name=CCP44108.1;Note=Rv1350%2C (MTCY02B10.14)%2C len: 247 aa. Probable fabG2%2C3-oxoacyl-[acyl-carrier protein] reductase%2C highly similar to many e.g. NP_350157.1|NC_003030 3-ketoacyl-acyl carrier protein reductase from Clostridium acetobutylicum (249 aa)%3B NP_229523.1|NC_000853 3-oxoacyl-(acyl carrier protein) reductase from Thermotoga maritima (246 aa)%3B AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa)%3B etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fabG2;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1350;product=Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase);protein_id=CCP44108.1;transl_table=11
AL123456.3	EMBL	gene	1518231	1518560	.	+	.	ID=gene-Rv1351;Name=Rv1351;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1351
AL123456.3	EMBL	CDS	1518231	1518560	.	+	0	ID=cds-CCP44109.1;Parent=gene-Rv1351;Dbxref=EnsemblGenomes-Gn:Rv1351,EnsemblGenomes-Tr:CCP44109,NCBI_GP:CCP44109.1;Name=CCP44109.1;Note=Rv1351%2C (MTCY02B10.15)%2C len: 109 aa. Hypothetical unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C 2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1351;product=Hypothetical protein;protein_id=CCP44109.1;transl_table=11
AL123456.3	EMBL	gene	1518763	1519134	.	+	.	ID=gene-Rv1352;Name=Rv1352;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1352
AL123456.3	EMBL	CDS	1518763	1519134	.	+	0	ID=cds-CCP44110.1;Parent=gene-Rv1352;Dbxref=EnsemblGenomes-Gn:Rv1352,EnsemblGenomes-Tr:CCP44110,GOA:P9WM15,NCBI_GP:CCP44110.1;Name=CCP44110.1;Note=Rv1352%2C (MTCY02B10.16)%2C len: 123 aa. Conserved protein%2C some similarity to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa)%2C FASTA scores: E(): 4e-05%2C (36.2%25 identity in 116 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1352;product=Conserved protein;protein_id=CCP44110.1;transl_table=11
AL123456.3	EMBL	gene	1519200	1519985	.	-	.	ID=gene-Rv1353c;Name=Rv1353c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1353c
AL123456.3	EMBL	CDS	1519200	1519985	.	-	0	ID=cds-CCP44111.1;Parent=gene-Rv1353c;Dbxref=EnsemblGenomes-Gn:Rv1353c,EnsemblGenomes-Tr:CCP44111,GOA:P9WMD3,InterPro:IPR001647,InterPro:IPR004111,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR023772,NCBI_GP:CCP44111.1;Name=CCP44111.1;Note=Rv1353c%2C (MTCY02B10.17c)%2C len: 261 aa. Probable transcriptional regulatory protein%2C similar to TER1_ECOLI|P03038 tetracycline repressor protein class a from Escherichia coli (216 aa)%2C FASTA scores%2C opt: 231%2CE(): 1.6e-08%2C (31.3%25 identity in 211 aa overlap). Helix turn helix motif present at aa 3859 (+3.59 SD). Belongs to the TetR/AcrR family of transcriptional regulators.;gbkey=CDS;locus_tag=Rv1353c;product=Probable transcriptional regulatory protein;protein_id=CCP44111.1;transl_table=11
AL123456.3	EMBL	gene	1520005	1521876	.	-	.	ID=gene-Rv1354c;Name=Rv1354c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1354c
AL123456.3	EMBL	CDS	1520005	1521876	.	-	0	ID=cds-CCP44112.1;Parent=gene-Rv1354c;Dbxref=EnsemblGenomes-Gn:Rv1354c,EnsemblGenomes-Tr:CCP44112,GOA:P9WM13,InterPro:IPR000160,InterPro:IPR001633,InterPro:IPR003018,InterPro:IPR029016,InterPro:IPR029787,NCBI_GP:CCP44112.1;Name=CCP44112.1;Note=Rv1354c%2C (MTCY02B10.18c)%2C len: 623 aa. Conserved hypothetical protein%2C similar to many hypothetical proteins e.g. the C-terminus of G1001455 Synechocystis sp. (1244 aa)%2C FASTA scores: opt: 933%2C E(): 0%2C (36.8%25 identity in 462 aa overlap)%3B also similar to Rv1357c|MTCY02B10.21c (34.0%25 identity in 253 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1354c;product=Conserved hypothetical protein;protein_id=CCP44112.1;transl_table=11
AL123456.3	EMBL	gene	1521885	1524032	.	-	.	ID=gene-Rv1355c;Name=moeY;gbkey=Gene;gene=moeY;gene_biotype=protein_coding;locus_tag=Rv1355c
AL123456.3	EMBL	CDS	1521885	1524032	.	-	0	ID=cds-CCP44113.1;Parent=gene-Rv1355c;Dbxref=EnsemblGenomes-Gn:Rv1355c,EnsemblGenomes-Tr:CCP44113,GOA:P9WM11,InterPro:IPR000415,InterPro:IPR000594,InterPro:IPR009036,InterPro:IPR016040,NCBI_GP:CCP44113.1;Name=CCP44113.1;Note=Rv1355c%2C (MTCY02B10.19c)%2C len: 715 aa. Possible moeY%2C Molybdopterin biosynthesis protein%2C very weak similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis moeb protein (249 aa)%2C FASTA scores%2C opt: 180%2C E(): 8.5e-05%2C (29.3%25 identity in 174 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moeY;locus_tag=Rv1355c;product=Possible molybdopterin biosynthesis protein MoeY;protein_id=CCP44113.1;transl_table=11
AL123456.3	EMBL	gene	1524029	1524820	.	-	.	ID=gene-Rv1356c;Name=Rv1356c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1356c
AL123456.3	EMBL	CDS	1524029	1524820	.	-	0	ID=cds-CCP44114.1;Parent=gene-Rv1356c;Dbxref=EnsemblGenomes-Gn:Rv1356c,EnsemblGenomes-Tr:CCP44114,NCBI_GP:CCP44114.1;Name=CCP44114.1;Note=Rv1356c%2C (MTCY02B10.20c)%2C len: 263 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1356c;product=Hypothetical protein;protein_id=CCP44114.1;transl_table=11
AL123456.3	EMBL	gene	1525293	1526216	.	-	.	ID=gene-Rv1357c;Name=Rv1357c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1357c
AL123456.3	EMBL	CDS	1525293	1526216	.	-	0	ID=cds-CCP44115.1;Parent=gene-Rv1357c;Dbxref=EnsemblGenomes-Gn:Rv1357c,EnsemblGenomes-Tr:CCP44115,GOA:P9WM07,InterPro:IPR001633,NCBI_GP:CCP44115.1;Name=CCP44115.1;Note=Rv1357c%2C (MTCY02B10.21c)%2C len: 307 aa. Conserved hypothetical protein%2C similar to members of the YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical protein Y4ll from Rhizobium sp. (827 aa)%2C FASTA scores: E(): 0%2C (37.7%25 identity in 257 aa overlap)%2C also similar to Rv1354c|MTCY02B10.18c (34.0%25 identity in 253 aa overlap). Belongs to the YEGE/YHDA/YHJK/YJCC family.;gbkey=CDS;locus_tag=Rv1357c;product=Conserved hypothetical protein;protein_id=CCP44115.1;transl_table=11
AL123456.3	EMBL	gene	1526612	1530091	.	+	.	ID=gene-Rv1358;Name=Rv1358;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1358
AL123456.3	EMBL	CDS	1526612	1530091	.	+	0	ID=cds-CCP44116.1;Parent=gene-Rv1358;Dbxref=EnsemblGenomes-Gn:Rv1358,EnsemblGenomes-Tr:CCP44116,GOA:Q11028,InterPro:IPR000792,InterPro:IPR001054,InterPro:IPR011991,InterPro:IPR016032,InterPro:IPR027417,InterPro:IPR029787,UniProtKB/TrEMBL:Q11028,NCBI_GP:CCP44116.1;Name=CCP44116.1;Note=Rv1358%2C (MTCY02B10.22)%2C len: 1159 aa. Probable transcriptional regulatory protein%2C some similarity to AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa)%2C FASTA scores: opt: 210%2C E(): 5.5e-06%2C(27.5%25 identity in 739 aa overlap). Similar also to Rv0890C|MTCY31.18c (65.5%25 identity in 884 aa overlap) and to Rv1359|MTCY02B10.23 (43.7%25 identity in 197 aa overlap). Contains PS00017 ATP/GTP-binding site motif A%2C PS00622 Bacterial regulatory proteins%2C luxR family signature. Helix turn helix motif present at aa 1116-1137%2C (Score 1291%2C+3.59 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00622;locus_tag=Rv1358;product=Probable transcriptional regulatory protein;protein_id=CCP44116.1;transl_table=11
AL123456.3	EMBL	gene	1530173	1530925	.	+	.	ID=gene-Rv1359;Name=Rv1359;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1359
AL123456.3	EMBL	CDS	1530173	1530925	.	+	0	ID=cds-CCP44117.1;Parent=gene-Rv1359;Dbxref=EnsemblGenomes-Gn:Rv1359,EnsemblGenomes-Tr:CCP44117,GOA:P9WM05,InterPro:IPR001054,InterPro:IPR029787,NCBI_GP:CCP44117.1;Name=CCP44117.1;Note=Rv1359%2C (MTCY02B10.23)%2C len: 250 aa. Probable transcriptional regulatory protein%2C similar to Rv0891c|MTCY31.19c%2C (48.5%25 identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7%25 identity in 197 aa overlap).;gbkey=CDS;locus_tag=Rv1359;product=Probable transcriptional regulatory protein;protein_id=CCP44117.1;transl_table=11
AL123456.3	EMBL	gene	1531348	1532370	.	+	.	ID=gene-Rv1360;Name=Rv1360;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1360
AL123456.3	EMBL	CDS	1531348	1532370	.	+	0	ID=cds-CCP44118.1;Parent=gene-Rv1360;Dbxref=EnsemblGenomes-Gn:Rv1360,EnsemblGenomes-Tr:CCP44118,GOA:P9WM03,InterPro:IPR011251,InterPro:IPR019919,NCBI_GP:CCP44118.1;Name=CCP44118.1;Note=Rv1360%2C (MTCY02B10.24)%2C len: 340 aa. Probable oxidoreductase. Similar to Q49598|G1002714 coenzyme F420-dependent n5%2C n10-methylenetetrahydromethanopterin reductase from Methanopyrus kandleri (349 aa)%2C FASTA scores: opt: 264%2C E(): 4.4e-11%2C (26.3%25 identity in 323 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1360;product=Probable oxidoreductase;protein_id=CCP44118.1;transl_table=11
AL123456.3	EMBL	gene	1532443	1533633	.	-	.	ID=gene-Rv1361c;Name=PPE19;gbkey=Gene;gene=PPE19;gene_biotype=protein_coding;gene_synonym=mtb39b;locus_tag=Rv1361c
AL123456.3	EMBL	CDS	1532443	1533633	.	-	0	ID=cds-CCP44119.1;Parent=gene-Rv1361c;Dbxref=EnsemblGenomes-Gn:Rv1361c,EnsemblGenomes-Tr:CCP44119,GOA:P9WI25,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44119.1;Name=CCP44119.1;Note=Rv1361c%2C (MTCY02B10.25c)%2C len: 396 aa. PPE19 (alternate gene name: mtb39b). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C highly similar to many e.g. Rv1196|MTCI364.08|PPE18%2C FASTA scores: E(): 0%2C (84.9%25 identity in 397 aa overlap)%3B MTCY274.23c (42.3%25 identity in 416 aa overlap)%3B etc. Contains PS00501 Signal peptidases I serine active site. Note that expression of Rv1361c was demonstrated in lysates by immunodetection (see Dillon et al.%2C 1999). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE19;inference=protein motif:PROSITE:PS00501;locus_tag=Rv1361c;product=PPE family protein PPE19;protein_id=CCP44119.1;transl_table=11
AL123456.3	EMBL	gene	1533948	1534610	.	-	.	ID=gene-Rv1362c;Name=Rv1362c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1362c
AL123456.3	EMBL	CDS	1533948	1534610	.	-	0	ID=cds-CCP44120.1;Parent=gene-Rv1362c;Dbxref=EnsemblGenomes-Gn:Rv1362c,EnsemblGenomes-Tr:CCP44120,GOA:P9WM01,NCBI_GP:CCP44120.1;Name=CCP44120.1;Note=Rv1362c%2C (MTCY02B10.26c)%2C len: 220 aa. Possible membrane protein%2C similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9%25 identity in 216 aa overlap)%2C Rv0177%2C Rv1973%2C Rv1972%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1362c;product=Possible membrane protein;protein_id=CCP44120.1;transl_table=11
AL123456.3	EMBL	gene	1534607	1535392	.	-	.	ID=gene-Rv1363c;Name=Rv1363c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1363c
AL123456.3	EMBL	CDS	1534607	1535392	.	-	0	ID=cds-CCP44121.1;Parent=gene-Rv1363c;Dbxref=EnsemblGenomes-Gn:Rv1363c,EnsemblGenomes-Tr:CCP44121,GOA:P9WLZ9,NCBI_GP:CCP44121.1;Name=CCP44121.1;Note=Rv1363c%2C (MTCY02B10.27c)%2C len: 261 aa. Possible membrane protein%2C similar to Mycobacterium tuberculosis hypothetical proteins Rv1362c|MTCY02B10.26c (25.9%25 identity in 216 aa overlap)%3B Rv1972|MTV051.10 and Rv0177 etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1363c;product=Possible membrane protein;protein_id=CCP44121.1;transl_table=11
AL123456.3	EMBL	gene	1535417	1535716	.	-	.	ID=gene-mcr15;Name=mcr15;gbkey=Gene;gene=mcr15;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1535417	1535716	.	-	.	ID=rna-mcr15;Parent=gene-mcr15;Note=mcr15%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped.;gbkey=ncRNA;gene=mcr15;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1535417	1535716	.	-	.	ID=exon-mcr15-1;Parent=rna-mcr15;Note=mcr15%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped.;gbkey=ncRNA;gene=mcr15;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1535683	1537644	.	-	.	ID=gene-Rv1364c;Name=Rv1364c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1364c
AL123456.3	EMBL	CDS	1535683	1537644	.	-	0	ID=cds-CCP44122.1;Parent=gene-Rv1364c;Dbxref=EnsemblGenomes-Gn:Rv1364c,EnsemblGenomes-Tr:CCP44122,GOA:P9WLZ7,InterPro:IPR000014,InterPro:IPR000700,InterPro:IPR001610,InterPro:IPR001932,InterPro:IPR002645,InterPro:IPR003594,InterPro:IPR013656,PDB:3K3C,PDB:3K3D,PDB:3KE6,PDB:3KX0,NCBI_GP:CCP44122.1;Name=CCP44122.1;Note=Rv1364c%2C (MTCY02B10.28c)%2C len: 653 aa. Possible sigma factor regulatory protein%2C some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa)%2C FASTA scores: opt: 224%2C E(): 2e-07%2C (25.8%25 identity in 244 aa overlap). Also known as mursiF.;gbkey=CDS;locus_tag=Rv1364c;product=Possible sigma factor regulatory protein;protein_id=CCP44122.1;transl_table=11
AL123456.3	EMBL	gene	1537783	1538169	.	-	.	ID=gene-Rv1365c;Name=rsfA;gbkey=Gene;gene=rsfA;gene_biotype=protein_coding;locus_tag=Rv1365c
AL123456.3	EMBL	CDS	1537783	1538169	.	-	0	ID=cds-CCP44123.1;Parent=gene-Rv1365c;Dbxref=EnsemblGenomes-Gn:Rv1365c,EnsemblGenomes-Tr:CCP44123,GOA:P9WGE3,InterPro:IPR002645,InterPro:IPR003658,NCBI_GP:CCP44123.1;Name=CCP44123.1;Note=Rv1365c%2C (MTCY02B10.29c)%2C len: 128 aa. RsfA%2Canti-anti-sigma factor (see citation below)%2C similar to other Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08 (148 aa)%2C FASTA scores: E(): 0%2C (53.6%25 identity in 125 aa overlap)%3B Rv1904%2C Rv3687c. Weak similarity to putative anti-anti-sigma factors e.g. AF134889|AF134889_1 Streptomyces coelicolor (113 aa)%2C FASTA scores: opt: 137%2C E(): 0.004%2C (26.0%25 identity in 100 aa overlap).;gbkey=CDS;gene=rsfA;locus_tag=Rv1365c;product=Anti-anti-sigma factor RsfA (anti-sigma factor antagonist) (regulator of sigma F A);protein_id=CCP44123.1;transl_table=11
AL123456.3	EMBL	gene	1538390	1539211	.	+	.	ID=gene-Rv1366;Name=Rv1366;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1366
AL123456.3	EMBL	CDS	1538390	1539211	.	+	0	ID=cds-CCP44124.1;Parent=gene-Rv1366;Dbxref=EnsemblGenomes-Gn:Rv1366,EnsemblGenomes-Tr:CCP44124,GOA:P9WLZ5,InterPro:IPR007685,NCBI_GP:CCP44124.1;Name=CCP44124.1;Note=Rv1366%2C (MTCY02B10.30)%2C len: 273 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1366;product=Hypothetical protein;protein_id=CCP44124.1;transl_table=11
AL123456.3	EMBL	gene	1539180	1539440	.	+	.	ID=gene-Rv1366A;Name=Rv1366A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1366A
AL123456.3	EMBL	CDS	1539180	1539440	.	+	0	ID=cds-CCP44125.1;Parent=gene-Rv1366A;Dbxref=EnsemblGenomes-Gn:Rv1366A,EnsemblGenomes-Tr:CCP44125,UniProtKB/TrEMBL:V5QQR7,NCBI_GP:CCP44125.1;Name=CCP44125.1;Note=Rv1366A%2C len: 86 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1366A;product=Conserved protein;protein_id=CCP44125.1;transl_table=11
AL123456.3	EMBL	gene	1539512	1540645	.	-	.	ID=gene-Rv1367c;Name=Rv1367c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1367c
AL123456.3	EMBL	CDS	1539512	1540645	.	-	0	ID=cds-CCP44126.1;Parent=gene-Rv1367c;Dbxref=EnsemblGenomes-Gn:Rv1367c,EnsemblGenomes-Tr:CCP44126,GOA:P9WLZ3,InterPro:IPR001466,InterPro:IPR012338,NCBI_GP:CCP44126.1;Name=CCP44126.1;Note=Rv1367c%2C (MTCY02B12.01c%2CMTCY02B10.31c)%2C len: 377 aa. Conserved protein. Some similarity to penicillin binding proteins e.g. PBPE_BACSU|P32959 penicillin-binding protein 4* (pbp 4*) from Bacillus subtilis (451 aa)%2C FASTA scores: E(): 6.9e-06%2C (23.6%25 identity in 373 aa overlap). Similar to AL031107|SC5A7.06 hypothetical protein from Streptomyces coelicolor (409 aa)%2C FASTA scores: opt: 675%2C E(): 0%2C (40.4%25 identity in 339 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1367c;product=Conserved protein;protein_id=CCP44126.1;transl_table=11
AL123456.3	EMBL	gene	1541020	1541805	.	+	.	ID=gene-Rv1368;Name=lprF;gbkey=Gene;gene=lprF;gene_biotype=protein_coding;locus_tag=Rv1368
AL123456.3	EMBL	CDS	1541020	1541805	.	+	0	ID=cds-CCP44127.1;Parent=gene-Rv1368;Dbxref=EnsemblGenomes-Gn:Rv1368,EnsemblGenomes-Tr:CCP44127,GOA:P9WK47,InterPro:IPR009830,InterPro:IPR029046,NCBI_GP:CCP44127.1;Name=CCP44127.1;Note=Rv1368%2C (MTCY02B12.02)%2C len: 261 aa. Probable lprF%2Cconserved lipoprotein%3B similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|Y08C_MYCTU|Q11049 hypothetical 26.4 kDa protein cy50.12. (257 aa)%2C FASTA scores: opt: 286%2C E(): 5.3e-11%2C(26.3%25 identity in 270 aa overlap)%2C also Rv1411c|MTCY21B4.28c%2C (32.8%25 identity in 253 aa overlap) and Rv2945c. Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Belongs to the LPPX/lprafg family of lipoproteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprF;locus_tag=Rv1368;product=Probable conserved lipoprotein LprF;protein_id=CCP44127.1;transl_table=11
AL123456.3	EMBL	repeat_region	1541949	1541951	.	+	.	ID=id-AL123456.3:1541949..1541951;Note=3 bp direct repeat%2C CGG%2C at 3' end of IS6110 target sequence;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	1541952	1543306	.	-	.	ID=id-AL123456.3:1541952..1543306;Note=IS6110-2%2C len: 1355 nt. Almost identical to Insertion sequence IS986 element.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-2
AL123456.3	EMBL	gene	1541994	1542980	.	-	.	ID=gene-Rv1369c;Name=Rv1369c;end_range=1542980,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1369c;partial=true
AL123456.3	EMBL	CDS	1541994	1542980	.	-	0	ID=cds-CCP44128.1;Parent=gene-Rv1369c;Dbxref=EnsemblGenomes-Gn:Rv1369c,EnsemblGenomes-Tr:CCP44128,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP44128.1;Name=CCP44128.1;Note=Rv1369c%2C (MTCY02B12.03c)%2C len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv1368c and Rv1369c%2C the sequence UUUUAAAG (directly upstream of Rv1369c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 34 aa).;end_range=1542980,.;gbkey=CDS;locus_tag=Rv1369c;partial=true;product=Probable transposase;protein_id=CCP44128.1;transl_table=11
AL123456.3	EMBL	gene	1542929	1543255	.	-	.	ID=gene-Rv1370c;Name=Rv1370c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1370c
AL123456.3	EMBL	CDS	1542929	1543255	.	-	0	ID=cds-CCP44129.1;Parent=gene-Rv1370c;Dbxref=EnsemblGenomes-Gn:Rv1370c,EnsemblGenomes-Tr:CCP44129,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP44129.1;Name=CCP44129.1;Note=Rv1370c%2C (MTCY02B12.04c)%2C len: 108 aa. Putative transposase for IS6110 (fragment)%2C identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion element IS6110 hypothetical 12.0 kDa protein (108 aa)%2C fasta scores: E(): 1.4e-43%2C(100.00%25 identity in 108 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv1368c and Rv1369c%2C the sequence UUUUAAAG (directly upstream of Rv1369c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv1370c;product=Putative transposase for insertion sequence element IS6110 (fragment);protein_id=CCP44129.1;transl_table=11
AL123456.3	EMBL	repeat_region	1543307	1543309	.	+	.	ID=id-AL123456.3:1543307..1543309;Note=3 bp direct repeat%2C CGG%2C at 5' end of IS6110 target sequence;gbkey=repeat_region
AL123456.3	EMBL	gene	1543359	1544828	.	+	.	ID=gene-Rv1371;Name=Rv1371;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1371
AL123456.3	EMBL	CDS	1543359	1544828	.	+	0	ID=cds-CCP44130.1;Parent=gene-Rv1371;Dbxref=EnsemblGenomes-Gn:Rv1371,EnsemblGenomes-Tr:CCP44130,GOA:P71799,InterPro:IPR001199,InterPro:IPR005804,UniProtKB/TrEMBL:P71799,NCBI_GP:CCP44130.1;Name=CCP44130.1;Note=Rv1371%2C (MTCY02B12.05)%2C len: 489 aa. Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa)%2C FASTA score: opt: 173%2C E(): 0.00052%2C(22.4%25 identity in 438 aa overlap)%3B and Homo sapiens.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1371;product=Probable conserved membrane protein;protein_id=CCP44130.1;transl_table=11
AL123456.3	EMBL	gene	1544825	1546006	.	+	.	ID=gene-Rv1372;Name=Rv1372;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1372
AL123456.3	EMBL	CDS	1544825	1546006	.	+	0	ID=cds-CCP44131.1;Parent=gene-Rv1372;Dbxref=EnsemblGenomes-Gn:Rv1372,EnsemblGenomes-Tr:CCP44131,GOA:P9WPF1,InterPro:IPR001099,InterPro:IPR011141,InterPro:IPR012328,InterPro:IPR016038,InterPro:IPR016039,PDB:1TED,PDB:1TEE,NCBI_GP:CCP44131.1;Name=CCP44131.1;Note=Rv1372%2C (MTCY02B12.06)%2C len: 393 aa. Conserved hypothetical protein%2C similar to several chalcone synthases e.g. CHS2_GERHY|P48391 chalcone synthase 2 from gerbra hybrid (402 aa)%2C FASTA scores: opt: 511%2C E(): 7e-26%2C (28.4%25 identity in 380 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical chalcone synthases%2C Rv1665%2CRv1660.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1372;product=Conserved hypothetical protein;protein_id=CCP44131.1;transl_table=11
AL123456.3	EMBL	gene	1546012	1546992	.	+	.	ID=gene-Rv1373;Name=Rv1373;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1373
AL123456.3	EMBL	CDS	1546012	1546992	.	+	0	ID=cds-CCP44132.1;Parent=gene-Rv1373;Dbxref=EnsemblGenomes-Gn:Rv1373,EnsemblGenomes-Tr:CCP44132,GOA:P9WGB9,InterPro:IPR000863,InterPro:IPR027417,NCBI_GP:CCP44132.1;Name=CCP44132.1;Note=Rv1373%2C (MTCY02B12.07)%2C len: 326 aa. Glycolipid sulfotransferase (see citation below)%3B slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (296 aa)%2C FASTA scores%2C opt: 165%2C E():0.00054%2C (24.5%25 identity in 294 aa overlap).;gbkey=CDS;locus_tag=Rv1373;product=Glycolipid sulfotransferase;protein_id=CCP44132.1;transl_table=11
AL123456.3	EMBL	gene	1547072	1547530	.	-	.	ID=gene-Rv1374c;Name=Rv1374c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1374c
AL123456.3	EMBL	CDS	1547072	1547530	.	-	0	ID=cds-CCP44133.1;Parent=gene-Rv1374c;Dbxref=EnsemblGenomes-Gn:Rv1374c,EnsemblGenomes-Tr:CCP44133,UniProtKB/TrEMBL:P71802,NCBI_GP:CCP44133.1;Name=CCP44133.1;Note=Rv1374c%2C (MTCY02B12.08c)%2C len: 152 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1374c;product=Hypothetical protein;protein_id=CCP44133.1;transl_table=11
AL123456.3	EMBL	gene	1547129	1547268	.	+	.	ID=gene-MTS1082;Name=MTS1082;gbkey=Gene;gene=MTS1082;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1547129	1547268	.	+	.	ID=rna-MTS1082;Parent=gene-MTS1082;Note=MTS1082%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C ends not mapped%2C ~~150 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS1082;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1547129	1547268	.	+	.	ID=exon-MTS1082-1;Parent=rna-MTS1082;Note=MTS1082%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C ends not mapped%2C ~~150 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS1082;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1547832	1549151	.	+	.	ID=gene-Rv1375;Name=Rv1375;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1375
AL123456.3	EMBL	CDS	1547832	1549151	.	+	0	ID=cds-CCP44134.1;Parent=gene-Rv1375;Dbxref=EnsemblGenomes-Gn:Rv1375,EnsemblGenomes-Tr:CCP44134,InterPro:IPR003776,NCBI_GP:CCP44134.1;Name=CCP44134.1;Note=Rv1375%2C (MTCY02B12.09)%2C len: 439 aa. Conserved hypothetical protein%2C similar to hypothetical proteins from several organisms e.g. Q52871|U39409 Rhizobium leguminosarum (420 aa)%2C FASTA scores: E(): 2e-30%2C (34.4%25 identity in 378 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1375;product=Conserved hypothetical protein;protein_id=CCP44134.1;transl_table=11
AL123456.3	EMBL	gene	1549148	1550641	.	+	.	ID=gene-Rv1376;Name=Rv1376;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1376
AL123456.3	EMBL	CDS	1549148	1550641	.	+	0	ID=cds-CCP44135.1;Parent=gene-Rv1376;Dbxref=EnsemblGenomes-Gn:Rv1376,EnsemblGenomes-Tr:CCP44135,InterPro:IPR012924,InterPro:IPR016845,UniProtKB/TrEMBL:P71804,NCBI_GP:CCP44135.1;Name=CCP44135.1;Note=Rv1376%2C (MTCY02B12.10)%2C len: 497 aa. Conserved hypothetical protein%2C some similarity to hypothetical proteins from several organisms e.g. Q52872|U39409 Rhizobium leguminosarum (247 aa)%2C FASTA scores: E(): 2.1e-12%2C (34.7%25 identity in 219 aa overlap).;gbkey=CDS;locus_tag=Rv1376;product=Conserved hypothetical protein;protein_id=CCP44135.1;transl_table=11
AL123456.3	EMBL	gene	1550579	1551217	.	-	.	ID=gene-Rv1377c;Name=Rv1377c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1377c
AL123456.3	EMBL	CDS	1550579	1551217	.	-	0	ID=cds-CCP44136.1;Parent=gene-Rv1377c;Dbxref=EnsemblGenomes-Gn:Rv1377c,EnsemblGenomes-Tr:CCP44136,GOA:P71805,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:P71805,NCBI_GP:CCP44136.1;Name=CCP44136.1;Note=Rv1377c%2C (MTCY02B12.11c)%2C len: 212 aa. Putative transferase%2C similar to YQEM_BACSU|P54458 hypothetical 28.3 kDa protein from Bacillus subtilis (247 aa)%2C FASTA scores: opt: 221%2C E(): 7.6e-08%2C (30.6%25 identity in 144 aa overlap)%3B some similarity to methyltransferases%2C also similar to Mycobacterium tuberculosis hypothetical proteins Rv0560c%2CRv3699%2C and Rv2675c (~~ 39.1%25 identity in 197 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1377c;product=Putative transferase;protein_id=CCP44136.1;transl_table=11
AL123456.3	EMBL	gene	1551228	1552655	.	-	.	ID=gene-Rv1378c;Name=Rv1378c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1378c
AL123456.3	EMBL	CDS	1551228	1552655	.	-	0	ID=cds-CCP44137.1;Parent=gene-Rv1378c;Dbxref=EnsemblGenomes-Gn:Rv1378c,EnsemblGenomes-Tr:CCP44137,GOA:P71806,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:P71806,NCBI_GP:CCP44137.1;Name=CCP44137.1;Note=Rv1378c%2C (MTCY02B12.12c)%2C len: 475 aa. Conserved hypothetical protein%2C similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C (424 aa)%2C FASTA scores: E(): 0%2C (73.0%25 identity in 429 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1378c;product=Conserved hypothetical protein;protein_id=CCP44137.1;transl_table=11
AL123456.3	EMBL	gene	1552654	1553235	.	+	.	ID=gene-Rv1379;Name=pyrR;gbkey=Gene;gene=pyrR;gene_biotype=protein_coding;locus_tag=Rv1379
AL123456.3	EMBL	CDS	1552654	1553235	.	+	0	ID=cds-CCP44138.1;Parent=gene-Rv1379;Dbxref=EnsemblGenomes-Gn:Rv1379,EnsemblGenomes-Tr:CCP44138,GOA:P9WHK3,InterPro:IPR000836,InterPro:IPR023050,InterPro:IPR029057,PDB:1W30,NCBI_GP:CCP44138.1;Name=CCP44138.1;Note=Rv1379%2C (MTCY02B12.13)%2C len: 193 aa. Probable pyrR%2Cpyrimidine operon regulatory protein%2C similar to PYRR_BACCL|P41007 pyrimidine operon regulatory protein from Bacillus caldolyticus (179 aa)%2C FASTA scores: opt: 544%2CE(): 1.1e-30%2C (54.2%25 identity in 179 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrR;locus_tag=Rv1379;product=Probable pyrimidine operon regulatory protein PyrR;protein_id=CCP44138.1;transl_table=11
AL123456.3	EMBL	gene	1553232	1554191	.	+	.	ID=gene-Rv1380;Name=pyrB;gbkey=Gene;gene=pyrB;gene_biotype=protein_coding;locus_tag=Rv1380
AL123456.3	EMBL	CDS	1553232	1554191	.	+	0	ID=cds-CCP44139.1;Parent=gene-Rv1380;Dbxref=EnsemblGenomes-Gn:Rv1380,EnsemblGenomes-Tr:CCP44139,GOA:P9WIT7,InterPro:IPR002082,InterPro:IPR006130,InterPro:IPR006131,InterPro:IPR006132,NCBI_GP:CCP44139.1;Name=CCP44139.1;Note=Rv1380%2C (MTCY02B12.14)%2C len: 319 aa. Probable pyrB%2Caspartate carbamoyltransferase%2C similar to many e.g. PYRB_BACCL|P41008 aspartate carbamoyltransferase from Bacillus caldolyticus (308 aa)%2C FASTA scores%2C opt: 639%2CE(): 7.3e-36%2C (39.5%25 identity in 311 aa overlap). Contains PS00097 Aspartate and ornithine carbamoyltransferases signature. Belongs to the ATCases/OTCases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrB;inference=protein motif:PROSITE:PS00097;locus_tag=Rv1380;product=Probable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylase);protein_id=CCP44139.1;transl_table=11
AL123456.3	EMBL	gene	1554188	1555480	.	+	.	ID=gene-Rv1381;Name=pyrC;gbkey=Gene;gene=pyrC;gene_biotype=protein_coding;locus_tag=Rv1381
AL123456.3	EMBL	CDS	1554188	1555480	.	+	0	ID=cds-CCP44140.1;Parent=gene-Rv1381;Dbxref=EnsemblGenomes-Gn:Rv1381,EnsemblGenomes-Tr:CCP44140,GOA:P9WHL3,InterPro:IPR002195,InterPro:IPR004722,InterPro:IPR011059,NCBI_GP:CCP44140.1;Name=CCP44140.1;Note=Rv1381%2C (MTCY02B12.15)%2C len: 430 aa. Probable pyrC%2Cdihydroorotase%2C similar to many e.g. PYRC_BACCL|P46538 (40.5%25 identity in 395 aa overlap). Contains PS00483 Dihydroorotase signature 2. Belongs to the DHOase family. subfamily 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrC;inference=protein motif:PROSITE:PS00483;locus_tag=Rv1381;product=Probable dihydroorotase PyrC (DHOase);protein_id=CCP44140.1;transl_table=11
AL123456.3	EMBL	gene	1555477	1555974	.	+	.	ID=gene-Rv1382;Name=Rv1382;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1382
AL123456.3	EMBL	CDS	1555477	1555974	.	+	0	ID=cds-CCP44141.1;Parent=gene-Rv1382;Dbxref=EnsemblGenomes-Gn:Rv1382,EnsemblGenomes-Tr:CCP44141,GOA:P71810,UniProtKB/TrEMBL:P71810,NCBI_GP:CCP44141.1;Name=CCP44141.1;Note=Rv1382%2C (MTCY02B12.16)%2C len: 165 aa. Possible exported or membrane protein%2C hydrophobic domain at N-terminus. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1382;product=Probable export or membrane protein;protein_id=CCP44141.1;transl_table=11
AL123456.3	EMBL	gene	1555971	1557101	.	+	.	ID=gene-Rv1383;Name=carA;gbkey=Gene;gene=carA;gene_biotype=protein_coding;locus_tag=Rv1383
AL123456.3	EMBL	CDS	1555971	1557101	.	+	0	ID=cds-CCP44142.1;Parent=gene-Rv1383;Dbxref=EnsemblGenomes-Gn:Rv1383,EnsemblGenomes-Tr:CCP44142,GOA:P9WPK5,InterPro:IPR002474,InterPro:IPR006274,InterPro:IPR017926,InterPro:IPR029062,NCBI_GP:CCP44142.1;Name=CCP44142.1;Note=Rv1383%2C (MTCY02B12.17)%2C len: 376 aa. Probable carA%2CCarbamoyl-phosphate synthase small chain%2C similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate synthase small chain from Escherichia coli (382 aa)%2C FASTA scores: opt: 796%2C E(): 0%2C (45.5%25 identity in 382 aa overlap). Contains PS00442 Glutamine amidotransferases class-I active site. The gatase domain belongs to type-1 glutamine amidotransferases. subunit: composed of two chains%3B the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia%2C which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=carA;inference=protein motif:PROSITE:PS00442;locus_tag=Rv1383;product=Probable carbamoyl-phosphate synthase small chain CarA (carbamoyl-phosphate synthetase glutamine chain);protein_id=CCP44142.1;transl_table=11
AL123456.3	EMBL	gene	1557101	1560448	.	+	.	ID=gene-Rv1384;Name=carB;gbkey=Gene;gene=carB;gene_biotype=protein_coding;locus_tag=Rv1384
AL123456.3	EMBL	CDS	1557101	1560448	.	+	0	ID=cds-CCP44143.1;Parent=gene-Rv1384;Dbxref=EnsemblGenomes-Gn:Rv1384,EnsemblGenomes-Tr:CCP44143,GOA:P9WPK3,InterPro:IPR005479,InterPro:IPR005480,InterPro:IPR005481,InterPro:IPR005483,InterPro:IPR006275,InterPro:IPR011607,InterPro:IPR011761,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,NCBI_GP:CCP44143.1;Name=CCP44143.1;Note=Rv1384%2C (MTCY02B12.18-MTCY21B4.01)%2C len: 1115 aa. Probable carB%2C Carbamoyl-phosphate synthase large chain %2Csimilar to many e.g. CARB_ECOLI|P00968 E. coli (1072 aa)%2CFASTA scores: E(): 0%2C (52.3%25 identity in 1118 aa overlap). Contains two PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00866 Carbamoyl-phosphatesynthase subdomain signature 1. subunit: composed of two chains%3B the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia%2C which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=carB;inference=protein motif:PROSITE:PS00867;locus_tag=Rv1384;product=Probable carbamoyl-phosphate synthase large chain CarB (carbamoyl-phosphate synthetase ammonia chain);protein_id=CCP44143.1;transl_table=11
AL123456.3	EMBL	gene	1560445	1561269	.	+	.	ID=gene-Rv1385;Name=pyrF;gbkey=Gene;gene=pyrF;gene_biotype=protein_coding;locus_tag=Rv1385
AL123456.3	EMBL	CDS	1560445	1561269	.	+	0	ID=cds-CCP44144.1;Parent=gene-Rv1385;Dbxref=EnsemblGenomes-Gn:Rv1385,EnsemblGenomes-Tr:CCP44144,GOA:P9WIU3,InterPro:IPR001754,InterPro:IPR011060,InterPro:IPR011995,InterPro:IPR013785,InterPro:IPR018089,NCBI_GP:CCP44144.1;Name=CCP44144.1;Note=Rv1385%2C (MTCY21B4.02)%2C len: 274 aa. Probable pyrF%2Corotidine 5'-phosphate decarboxylase%2C identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. Belongs to the OMP decarboxylase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrF;inference=protein motif:PROSITE:PS00156;locus_tag=Rv1385;product=Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase);protein_id=CCP44144.1;transl_table=11
AL123456.3	EMBL	gene	1561464	1561772	.	+	.	ID=gene-Rv1386;Name=PE15;gbkey=Gene;gene=PE15;gene_biotype=protein_coding;locus_tag=Rv1386
AL123456.3	EMBL	CDS	1561464	1561772	.	+	0	ID=cds-CCP44145.1;Parent=gene-Rv1386;Dbxref=EnsemblGenomes-Gn:Rv1386,EnsemblGenomes-Tr:CCP44145,GOA:P9WIH1,InterPro:IPR000084,NCBI_GP:CCP44145.1;Name=CCP44145.1;Note=Rv1386%2C (MTCY21B4.03)%2C len: 102 aa. PE15%2C Member of Mycobacterium tuberculosis PE family (see Brennan %26 Delogu 2002)%2C similar to many e.g. G913039 ORF 3' of PGRS tandem repeat (polymorphic GC-rich sequence) (100 aa)%2C FASTA scores: opt: 149%2C E(): 0.0013%2C (31.5%25 identity in 92 aa overlap)%3B also similar to Q49943|U1756A (99 aa) (34.7%25 identity in 95 aa overlap) and G466937|U1620K (100 aa) (36.2%25 identity in 69 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE15;locus_tag=Rv1386;product=PE family protein PE15;protein_id=CCP44145.1;transl_table=11
AL123456.3	EMBL	gene	1561769	1563388	.	+	.	ID=gene-Rv1387;Name=PPE20;gbkey=Gene;gene=PPE20;gene_biotype=protein_coding;locus_tag=Rv1387
AL123456.3	EMBL	CDS	1561769	1563388	.	+	0	ID=cds-CCP44146.1;Parent=gene-Rv1387;Dbxref=EnsemblGenomes-Gn:Rv1387,EnsemblGenomes-Tr:CCP44146,InterPro:IPR000030,NCBI_GP:CCP44146.1;Name=CCP44146.1;Note=Rv1387%2C (MTCY21B4.04)%2C len: 539 aa. PPE20%2C Member of Mycobacterium tuberculosis PPE family of proteins%2C similar to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein cy251.15 (463 aa)%2C FASTA scores: E(): 4.2e-26%2C (37.7%25 identity in 531 aa overlap)%3B similar also to MTCY274.23c (37.5%25 identity in 168 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE20;inference=protein motif:PROSITE:PS00343;locus_tag=Rv1387;product=PPE family protein PPE20;protein_id=CCP44146.1;transl_table=11
AL123456.3	EMBL	gene	1563694	1564266	.	+	.	ID=gene-Rv1388;Name=mihF;gbkey=Gene;gene=mihF;gene_biotype=protein_coding;locus_tag=Rv1388
AL123456.3	EMBL	CDS	1563694	1564266	.	+	0	ID=cds-CCP44147.1;Parent=gene-Rv1388;Dbxref=EnsemblGenomes-Gn:Rv1388,EnsemblGenomes-Tr:CCP44147,GOA:P71658,UniProtKB/TrEMBL:P71658,NCBI_GP:CCP44147.1;Name=CCP44147.1;Note=Rv1388%2C (MTCY21B4.05)%2C len: 190 aa. Putative mihF%2Cintegration host factor. Almost identical to%2C but longer than%2C P96802|U75344 Mycobacterium smegmatis integration host factor (mIHF) for mycobacteriophage L5 (105 aa)%2C FASTA scores: E(): 0%2C (96.1%25 identity in 102 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mihF;locus_tag=Rv1388;product=Putative integration host factor MihF;protein_id=CCP44147.1;transl_table=11
AL123456.3	EMBL	gene	1564401	1565027	.	+	.	ID=gene-Rv1389;Name=gmk;gbkey=Gene;gene=gmk;gene_biotype=protein_coding;locus_tag=Rv1389
AL123456.3	EMBL	CDS	1564401	1565027	.	+	0	ID=cds-CCP44148.1;Parent=gene-Rv1389;Dbxref=EnsemblGenomes-Gn:Rv1389,EnsemblGenomes-Tr:CCP44148,GOA:P9WKE9,InterPro:IPR008144,InterPro:IPR008145,InterPro:IPR017665,InterPro:IPR020590,InterPro:IPR027417,PDB:1S4Q,PDB:1Z8F,PDB:1ZNW,PDB:1ZNX,PDB:1ZNY,PDB:1ZNZ,NCBI_GP:CCP44148.1;Name=CCP44148.1;Note=Rv1389%2C (MTCY21B4.06)%2C len: 208 aa. Probable gmk%2Cguanylate kinase%2C similar to e.g. KGUA_ECOLI|P24234 guanylate kinase from Escherichia coli (207 aa)%2C FASTA scores: opt: 424%2C E(): 6.6e-20%2C (35.9%25 identity in 184 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00856 Guanylate kinase signature. Belongs to the guanylate kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gmk;inference=protein motif:PROSITE:PS00856;locus_tag=Rv1389;product=Probable guanylate kinase Gmk;protein_id=CCP44148.1;transl_table=11
AL123456.3	EMBL	gene	1565093	1565425	.	+	.	ID=gene-Rv1390;Name=rpoZ;gbkey=Gene;gene=rpoZ;gene_biotype=protein_coding;locus_tag=Rv1390
AL123456.3	EMBL	CDS	1565093	1565425	.	+	0	ID=cds-CCP44149.1;Parent=gene-Rv1390;Dbxref=EnsemblGenomes-Gn:Rv1390,EnsemblGenomes-Tr:CCP44149,GOA:P9WGY5,InterPro:IPR003716,InterPro:IPR006110,InterPro:IPR012293,NCBI_GP:CCP44149.1;Name=CCP44149.1;Note=Rv1390%2C (MTCY21B4.07)%2C len: 110 aa. Probable rpoZ%2CDNA-directed RNA polymerase omega chain. Belongs to the RNA polymerase omega chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpoZ;locus_tag=Rv1390;product=Probable DNA-directed RNA polymerase (omega chain) RpoZ (transcriptase omega chain) (RNA polymerase omega subunit);protein_id=CCP44149.1;transl_table=11
AL123456.3	EMBL	gene	1565441	1566697	.	+	.	ID=gene-Rv1391;Name=dfp;gbkey=Gene;gene=dfp;gene_biotype=protein_coding;locus_tag=Rv1391
AL123456.3	EMBL	CDS	1565441	1566697	.	+	0	ID=cds-CCP44150.1;Parent=gene-Rv1391;Dbxref=EnsemblGenomes-Gn:Rv1391,EnsemblGenomes-Tr:CCP44150,GOA:P9WNZ1,InterPro:IPR003382,InterPro:IPR005252,InterPro:IPR007085,NCBI_GP:CCP44150.1;Name=CCP44150.1;Note=Rv1391%2C (MTCY21B4.08)%2C len: 418 aa. Probable dfp%2CDNA/pantothenate metabolism flavoprotein homolog%2C similar to many e.g. DFP_ECOLI|P24285 Escherichia coli (430 aa)%2CFASTA scores: opt: 763%2C E(): 0%2C (40.2%25 identity in 408 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dfp;locus_tag=Rv1391;product=Probable DNA/pantothenate metabolism flavoprotein homolog Dfp;protein_id=CCP44150.1;transl_table=11
AL123456.3	EMBL	gene	1566825	1568036	.	+	.	ID=gene-Rv1392;Name=metK;gbkey=Gene;gene=metK;gene_biotype=protein_coding;locus_tag=Rv1392
AL123456.3	EMBL	CDS	1566825	1568036	.	+	0	ID=cds-CCP44151.1;Parent=gene-Rv1392;Dbxref=EnsemblGenomes-Gn:Rv1392,EnsemblGenomes-Tr:CCP44151,GOA:P9WGV1,InterPro:IPR002133,InterPro:IPR022628,InterPro:IPR022629,InterPro:IPR022630,InterPro:IPR022631,InterPro:IPR022636,PDB:3TDE,NCBI_GP:CCP44151.1;Name=CCP44151.1;Note=Rv1392%2C (MTCY21B4.09)%2C len: 403 aa. Probable metK%2CS-adenosylmethionine synthetase%2C similar to many e.g. METK_STAAU|P50307 Staphylococcus aureus (397 aa)%2C FASTA scores: opt: 1484%2C E(): 0%2C (58.0%25 identity in 400 aa overlap). Contains PS00376 S-adenosylmethionine synthetase signature 1%2C PS00377 S-adenosylmethionine synthetase signature 2. Belongs to the adomet synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metK;inference=protein motif:PROSITE:PS00377;locus_tag=Rv1392;product=Probable S-adenosylmethionine synthetase MetK (mat) (AdoMet synthetase) (methionine adenosyltransferase);protein_id=CCP44151.1;transl_table=11
AL123456.3	EMBL	gene	1568109	1569587	.	-	.	ID=gene-Rv1393c;Name=Rv1393c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1393c
AL123456.3	EMBL	CDS	1568109	1569587	.	-	0	ID=cds-CCP44152.1;Parent=gene-Rv1393c;Dbxref=EnsemblGenomes-Gn:Rv1393c,EnsemblGenomes-Tr:CCP44152,GOA:P71662,UniProtKB/TrEMBL:P71662,NCBI_GP:CCP44152.1;Name=CCP44152.1;Note=Rv1393c%2C (MTCY21B4.10c)%2C len: 492 aa. Probable monooxygenase%2C similar to others e.g. CYMO_ACISP|P12015 cyclohexanone monooxygenase from Acinetobacter sp. (542 aa)%2C FASTA scores: E(): 0%2C (33.0%25 identity in 473 aa overlap)%3B also to Rv3083|MTCY31.20|E241788 hypothetical 55.0 kDa protein from Mycobacterium tuberculosis (495 aa) (36.3%25 identity in 490 aa overlap)%3B and Rv0565c%2C Rv3854c%2CRv3049c%2C Rv0892.;gbkey=CDS;locus_tag=Rv1393c;product=Probable monoxygenase;protein_id=CCP44152.1;transl_table=11
AL123456.3	EMBL	gene	1569584	1570969	.	-	.	ID=gene-Rv1394c;Name=cyp132;gbkey=Gene;gene=cyp132;gene_biotype=protein_coding;locus_tag=Rv1394c
AL123456.3	EMBL	CDS	1569584	1570969	.	-	0	ID=cds-CCP44153.1;Parent=gene-Rv1394c;Dbxref=EnsemblGenomes-Gn:Rv1394c,EnsemblGenomes-Tr:CCP44153,GOA:P9WPN3,InterPro:IPR001128,InterPro:IPR002401,InterPro:IPR017972,NCBI_GP:CCP44153.1;Name=CCP44153.1;Note=Rv1394c%2C (MT1439%2C MTCY21B4.11c)%2C len: 461 aa. Probable cyp132%2C cytochrome P450 132. Some similarity to others e.g. CP4B_HUMAN|P13584 human cytochrome p450 (511 aa)%2C FASTA scores: opt: 486%2C E(): 7.4e-21%2C (28.6%25 identity in 423 aa overlap)%3B etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. May belong to the cytochrome P450 family. Experimentally shown that the expression of cyp132 is induced by the transcriptional regulatory protein Rv1395 (Recchi et al.%2C 2003).;gbkey=CDS;gene=cyp132;inference=protein motif:PROSITE:PS00086;locus_tag=Rv1394c;product=Probable cytochrome P450 132 Cyp132;protein_id=CCP44153.1;transl_table=11
AL123456.3	EMBL	gene	1571047	1572081	.	+	.	ID=gene-Rv1395;Name=Rv1395;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1395
AL123456.3	EMBL	CDS	1571047	1572081	.	+	0	ID=cds-CCP44154.1;Parent=gene-Rv1395;Dbxref=EnsemblGenomes-Gn:Rv1395,EnsemblGenomes-Tr:CCP44154,GOA:P9WMJ1,InterPro:IPR009057,InterPro:IPR018060,InterPro:IPR020449,NCBI_GP:CCP44154.1;Name=CCP44154.1;Note=Rv1395%2C (MTCY21B4.12)%2C len: 344 aa. Transcriptional regulatory protein (see citation below)%2C similar to many e.g. URER_PROMI|Q02458 urease operon transcriptional activator from Proteus mirabilis (293 aa)%2C FASTA scores: E():1.5e-08%2C (41.7%25 identity in 84 aa overlap)%3B YHIX_ECOLI|P37639 hypothetical transcriptional regulatory protein from Escherichia coli (274 aa)%2C FASTA scores: opt: 238%2C E(): 3.5e-09%2C (27.3%25 identity in 249 aa overlap)%3B and G296916|X68281 possible virulence-regulating protein from Mycobacterium tuberculosis (339 aa)%2C FASTA scores: opt: 228%2C E(): 1.9e-08%2C (27.0%25 identity in 278 aa overlap). Helix turn helix motif present%2C aa 261-282 (+4.68 SD). Belongs to the AraC/XylS family of transcriptional regulators. 3' part corrected since first submission (-14 aa). Experimentally shown to induce the expression of the cytochrome P450 gene (Rv1394c) and represses its own transcription.;gbkey=CDS;locus_tag=Rv1395;product=Transcriptional regulatory protein;protein_id=CCP44154.1;transl_table=11
AL123456.3	EMBL	gene	1572127	1573857	.	-	.	ID=gene-Rv1396c;Name=PE_PGRS25;gbkey=Gene;gene=PE_PGRS25;gene_biotype=protein_coding;locus_tag=Rv1396c
AL123456.3	EMBL	CDS	1572127	1573857	.	-	0	ID=cds-CCP44155.1;Parent=gene-Rv1396c;Dbxref=EnsemblGenomes-Gn:Rv1396c,EnsemblGenomes-Tr:CCP44155,InterPro:IPR000084,UniProtKB/TrEMBL:P71664,NCBI_GP:CCP44155.1;Name=CCP44155.1;Note=Rv1396c%2C (MTCY21B4.13c)%2C len: 576 aa. PE_PGRS25%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002)%2Cstrong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa)%2C FASTA scores: opt: 1945%2C E(): 0%2C (57.5%25 identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A%2C similar to other PGRS-type sequences. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=PE_PGRS25;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1396c;product=PE-PGRS family protein PE_PGRS25;protein_id=CCP44155.1;transl_table=11
AL123456.3	EMBL	gene	1574112	1574513	.	-	.	ID=gene-Rv1397c;Name=vapC10;gbkey=Gene;gene=vapC10;gene_biotype=protein_coding;locus_tag=Rv1397c
AL123456.3	EMBL	CDS	1574112	1574513	.	-	0	ID=cds-CCP44156.1;Parent=gene-Rv1397c;Dbxref=EnsemblGenomes-Gn:Rv1397c,EnsemblGenomes-Tr:CCP44156,GOA:P9WFA7,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44156.1;Name=CCP44156.1;Note=Rv1397c%2C (MTCY21B4.14c)%2C len: 133 aa. Possible vapC10%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv1398c%2C contains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Conserved hypothetical protein%2Csimilar to Mycobacterium tuberculosis protein MTCY159.08C|Rv2548 (125 aa)%2C FASTA scores: E(): 2.3e-14%2C(42.4%25 identity in 125 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC10;locus_tag=Rv1397c;product=Possible toxin VapC10;protein_id=CCP44156.1;transl_table=11
AL123456.3	EMBL	gene	1574510	1574767	.	-	.	ID=gene-Rv1398c;Name=vapB10;gbkey=Gene;gene=vapB10;gene_biotype=protein_coding;locus_tag=Rv1398c
AL123456.3	EMBL	CDS	1574510	1574767	.	-	0	ID=cds-CCP44157.1;Parent=gene-Rv1398c;Dbxref=EnsemblGenomes-Gn:Rv1398c,EnsemblGenomes-Tr:CCP44157,GOA:P9WLZ1,InterPro:IPR002145,InterPro:IPR010985,InterPro:IPR013321,NCBI_GP:CCP44157.1;Name=CCP44157.1;Note=Rv1398c%2C (MTCY21B4.15c)%2C len: 85 aa. Possible vapB10%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv1397c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Rv2547|MTCY159.09C (85 aa)%2C FASTA scores: E(): 0.0035%2C(37.1%25 identity in 62 aa overlap)%3B Rv0581%2C Rv2871%2C Rv1241%2Cetc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB10;locus_tag=Rv1398c;product=Possible antitoxin VapB10;protein_id=CCP44157.1;transl_table=11
AL123456.3	EMBL	gene	1574850	1575809	.	-	.	ID=gene-Rv1399c;Name=nlhH;gbkey=Gene;gene=nlhH;gene_biotype=protein_coding;locus_tag=Rv1399c
AL123456.3	EMBL	CDS	1574850	1575809	.	-	0	ID=cds-CCP44158.1;Parent=gene-Rv1399c;Dbxref=EnsemblGenomes-Gn:Rv1399c,EnsemblGenomes-Tr:CCP44158,GOA:P9WK87,InterPro:IPR013094,InterPro:IPR029058,NCBI_GP:CCP44158.1;Name=CCP44158.1;Note=Rv1399c%2C (MTCY21B4.16c)%2C len: 319 aa. Possible nlhH%2Cnon lipolytic carboxylesterase%2C most similar to G695278 lipase like enzyme from Ralstonia eutropha (364 aa)%2C FASTA scores: opt: 648%2C E(): 4.4e-34%2C (37.3%25 identity in 327 aa ov erlap)%2C similar to Mycobacterium tuberculosis hypothetical lipases e.g. Rv2284%2C Rv2485c%2C Rv1426c%2C etc. Previously known as lipH.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nlhH;locus_tag=Rv1399c;product=Probable non lipolytic carboxylesterase NlhH;protein_id=CCP44158.1;transl_table=11
AL123456.3	EMBL	gene	1575834	1576796	.	-	.	ID=gene-Rv1400c;Name=lipI;gbkey=Gene;gene=lipI;gene_biotype=protein_coding;locus_tag=Rv1400c
AL123456.3	EMBL	CDS	1575834	1576796	.	-	0	ID=cds-CCP44159.1;Parent=gene-Rv1400c;Dbxref=EnsemblGenomes-Gn:Rv1400c,EnsemblGenomes-Tr:CCP44159,GOA:P71668,InterPro:IPR002168,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:P71668,NCBI_GP:CCP44159.1;Name=CCP44159.1;Note=Rv1400c%2C (MTCY21B4.17c)%2C len: 320 aa. Possible lipI%2Clipase%2C most similar to G695278 lipase like enzyme (364 aa)%2C FASTA sscores: opt: 611%2C E(): 3.5e-30%2C (36.6%25 identity in 352 aa overlap)%3B similar to M. tuberculosis hypothetical lipases e.g. Rv1399c|MTCY21B4.16c (58.1%25 identical in 315 aa overlap)%3B Rv1426c%2C Rv2284%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipI;locus_tag=Rv1400c;product=Probable lipase LipH;protein_id=CCP44159.1;transl_table=11
AL123456.3	EMBL	gene	1576930	1577532	.	+	.	ID=gene-Rv1401;Name=Rv1401;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1401
AL123456.3	EMBL	CDS	1576930	1577532	.	+	0	ID=cds-CCP44160.1;Parent=gene-Rv1401;Dbxref=EnsemblGenomes-Gn:Rv1401,EnsemblGenomes-Tr:CCP44160,GOA:P9WG51,InterPro:IPR012506,NCBI_GP:CCP44160.1;Name=CCP44160.1;Note=Rv1401%2C (MTCY21B4.18)%2C len: 200 aa. Possible membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1401;product=Possible membrane protein;protein_id=CCP44160.1;transl_table=11
AL123456.3	EMBL	gene	1577613	1579580	.	+	.	ID=gene-Rv1402;Name=priA;gbkey=Gene;gene=priA;gene_biotype=protein_coding;locus_tag=Rv1402
AL123456.3	EMBL	CDS	1577613	1579580	.	+	0	ID=cds-CCP44161.1;Parent=gene-Rv1402;Dbxref=EnsemblGenomes-Gn:Rv1402,EnsemblGenomes-Tr:CCP44161,GOA:P9WMQ9,NCBI_GP:CCP44161.1;Name=CCP44161.1;Note=Rv1402%2C (MTCY21B4.19)%2C len: 655 aa. Putative priA%2Cprimosomal protein N'. Similar to e.g. PRIA_ECOLI|P17888 primosomal protein N' (replication factor Y) (732 aa)%2CFASTA scores%2C opt: 386%2C E(): 1.3e-16%2C (27.6%25 identity in 711 aa overlap). Compared to other bacterial priA%2C it has a very divergent helicase domain. Belongs to the helicase family. PRIA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=priA;locus_tag=Rv1402;product=Putative primosomal protein N' PriA (replication factor Y);protein_id=CCP44161.1;transl_table=11
AL123456.3	EMBL	gene	1579598	1580422	.	-	.	ID=gene-Rv1403c;Name=Rv1403c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1403c
AL123456.3	EMBL	CDS	1579598	1580422	.	-	0	ID=cds-CCP44162.1;Parent=gene-Rv1403c;Dbxref=EnsemblGenomes-Gn:Rv1403c,EnsemblGenomes-Tr:CCP44162,GOA:P9WLY9,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP44162.1;Name=CCP44162.1;Note=Rv1403c%2C (MTCY21B4.20c)%2C len: 274 aa. Putative methyltransferase%2C similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa)%2CFASTA scores: opt: 217%2C E(): 1.1e-07%2C (37.1%25 identity in 105 aa overlap)%3B similar to Rv1405c|MTCY21B4.22c (59.3%25 identity in 273 aa overlap) and to Rv1523%2C Rv2952%2C etc.;gbkey=CDS;locus_tag=Rv1403c;product=Putative methyltransferase;protein_id=CCP44162.1;transl_table=11
AL123456.3	EMBL	gene	1580591	1581073	.	+	.	ID=gene-Rv1404;Name=Rv1404;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1404
AL123456.3	EMBL	CDS	1580591	1581073	.	+	0	ID=cds-CCP44163.1;Parent=gene-Rv1404;Dbxref=EnsemblGenomes-Gn:Rv1404,EnsemblGenomes-Tr:CCP44163,GOA:P71672,InterPro:IPR000835,InterPro:IPR011991,InterPro:IPR023187,PDB:2NYX,UniProtKB/TrEMBL:P71672,NCBI_GP:CCP44163.1;Name=CCP44163.1;Note=Rv1404%2C (MTCY21B4.21)%2C len: 160 aa. Probable transcriptional regulatory protein%2C some similarity to MARR_ECOLI|P27245 multiple antibiotic resistance protein from Escherichia coli (125 aa)%2C FASTA scores: opt: 136%2CE(): 0.004%2C (35.1%25 identity in 74 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1404;product=Probable transcriptional regulatory protein;protein_id=CCP44163.1;transl_table=11
AL123456.3	EMBL	gene	1581145	1581969	.	-	.	ID=gene-Rv1405c;Name=Rv1405c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1405c
AL123456.3	EMBL	CDS	1581145	1581969	.	-	0	ID=cds-CCP44164.1;Parent=gene-Rv1405c;Dbxref=EnsemblGenomes-Gn:Rv1405c,EnsemblGenomes-Tr:CCP44164,GOA:P9WLY7,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP44164.1;Name=CCP44164.1;Note=Rv1405c%2C (MTCY21B4.22c)%2C len: 274 aa. Putative methyltransferase%2C most similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa)%2CFASTA scores: opt: 219%2C E(): 2.6e-07%2C (29.9%25 identity in 144 aa overlap)%3B similar to Rv1403c|MTCY21B4.20c (59.3%25 identity in 273 aa overlap)%2C Rv1523%2C Rv2952%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1405c;product=Putative methyltransferase;protein_id=CCP44164.1;transl_table=11
AL123456.3	EMBL	gene	1582166	1583104	.	+	.	ID=gene-Rv1406;Name=fmt;gbkey=Gene;gene=fmt;gene_biotype=protein_coding;locus_tag=Rv1406
AL123456.3	EMBL	CDS	1582166	1583104	.	+	0	ID=cds-CCP44165.1;Parent=gene-Rv1406;Dbxref=EnsemblGenomes-Gn:Rv1406,EnsemblGenomes-Tr:CCP44165,GOA:P9WND3,InterPro:IPR002376,InterPro:IPR005793,InterPro:IPR005794,InterPro:IPR011034,InterPro:IPR015518,NCBI_GP:CCP44165.1;Name=CCP44165.1;Note=Rv1406%2C (MTCY21B4.23)%2C len: 312 aa. Probable fmt%2Cmethionyl-tRNA formyltransferase%2C similar to many e.g. FMT_ECOLI|P23882 Escherichia coli (314 aa)%2C FASTA scores: opt: 616%2C E(): 6.7e-31%2C (39.3%25 identity in 303 aa overlap). Belongs to the FMT family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fmt;locus_tag=Rv1406;product=Probable methionyl-tRNA formyltransferase Fmt;protein_id=CCP44165.1;transl_table=11
AL123456.3	EMBL	gene	1583101	1584474	.	+	.	ID=gene-Rv1407;Name=fmu;gbkey=Gene;gene=fmu;gene_biotype=protein_coding;locus_tag=Rv1407
AL123456.3	EMBL	CDS	1583101	1584474	.	+	0	ID=cds-CCP44166.1;Parent=gene-Rv1407;Dbxref=EnsemblGenomes-Gn:Rv1407,EnsemblGenomes-Tr:CCP44166,GOA:P9WGX3,InterPro:IPR001678,InterPro:IPR006027,InterPro:IPR018314,InterPro:IPR023267,InterPro:IPR029063,NCBI_GP:CCP44166.1;Name=CCP44166.1;Note=Rv1407%2C (MTCY21B4.24)%2C len: 457 aa. Probable fmu protein%2C similar to SUN_ECOLI|P36929 sun protein (fmu protein) from Escherichia coli (429 aa)%2C FASTA scores: E(): 2.5e-20%2C (30.6%25 identity in 451 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fmu;locus_tag=Rv1407;product=Probable Fmu protein (sun protein);protein_id=CCP44166.1;transl_table=11
AL123456.3	EMBL	gene	1584499	1585197	.	+	.	ID=gene-Rv1408;Name=rpe;gbkey=Gene;gene=rpe;gene_biotype=protein_coding;locus_tag=Rv1408
AL123456.3	EMBL	CDS	1584499	1585197	.	+	0	ID=cds-CCP44167.1;Parent=gene-Rv1408;Dbxref=EnsemblGenomes-Gn:Rv1408,EnsemblGenomes-Tr:CCP44167,GOA:P9WI51,InterPro:IPR000056,InterPro:IPR011060,InterPro:IPR013785,InterPro:IPR026019,NCBI_GP:CCP44167.1;Name=CCP44167.1;Note=Rv1408%2C (MTCY21B4.25)%2C len: 232 aa. Probable rpe%2Cribulose-phosphate 3-epimerase%2C similar to many e.g. CXEC_ALCEU|P40117 (241 aa)%2C FASTA scores: opt: 638%2C E(): 1.5e-34%2C (48.3%25 identity in 234 aa overlap)%3B and RPE_ECOLI|P32661 ribulose-phosphate 3-epimerase (225 aa)%2CFASTA scores: E(): 0%2C (46.2%25 identity in 221 aa overlap). Contains PS01085 Ribulose-phosphate 3-epimerase family signature 1. Belongs to the ribulose-phosphate 3-epimerase family.;gbkey=CDS;gene=rpe;inference=protein motif:PROSITE:PS01086;locus_tag=Rv1408;product=Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase);protein_id=CCP44167.1;transl_table=11
AL123456.3	EMBL	gene	1585194	1586213	.	+	.	ID=gene-Rv1409;Name=ribG;gbkey=Gene;gene=ribG;gene_biotype=protein_coding;gene_synonym=ribD;locus_tag=Rv1409
AL123456.3	EMBL	CDS	1585194	1586213	.	+	0	ID=cds-CCP44168.1;Parent=gene-Rv1409;Dbxref=EnsemblGenomes-Gn:Rv1409,EnsemblGenomes-Tr:CCP44168,GOA:P9WPH1,InterPro:IPR002125,InterPro:IPR002734,InterPro:IPR004794,InterPro:IPR016192,InterPro:IPR016193,InterPro:IPR024072,NCBI_GP:CCP44168.1;Name=CCP44168.1;Note=Rv1409%2C (MTCY21B4.26)%2C len: 339 aa. Probable ribG (alternate gene name: ribD)%2C bifunctional riboflavin biosynthesis protein%2C including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase%2C similar to many e.g. RIBD_ECOLI|P25539 riboflavin-specific deaminase from Escherichia coli (367 aa)%2C FASTA scores: E(): 0%2C (39.8%25 identity in 364 aa overlap)%3B etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. In the N-terminal section%3B belongs to the cytidine and deoxycytidylate deaminases family. In the C-terminal section%3B belongs to the HTP reductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ribG;inference=protein motif:PROSITE:PS00903;locus_tag=Rv1409;product=Probable bifunctional riboflavin biosynthesis protein RibG : diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase);protein_id=CCP44168.1;transl_table=11
AL123456.3	EMBL	gene	1586210	1587766	.	-	.	ID=gene-Rv1410c;Name=Rv1410c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1410c
AL123456.3	EMBL	CDS	1586210	1587766	.	-	0	ID=cds-CCP44169.1;Parent=gene-Rv1410c;Dbxref=EnsemblGenomes-Gn:Rv1410c,EnsemblGenomes-Tr:CCP44169,GOA:P9WJY3,InterPro:IPR005829,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP44169.1;Name=CCP44169.1;Note=Rv1410c%2C (MTCY21B4.27c)%2C len: 518 aa. Aminoglycoside/tetracycline-transport integral membrane protein (see citation below)%2C member of major facilitator superfamily (MFS)%2C similar to others e.g. AC22_STRCO|P46105 probable actinorhodin transporter from Streptomyces coelicolor (578 aa)%2C FASTA scores: opt: 442%2C E(): 4.9e-21%2C(28.5%25 identity in 466 aa overlap)%3B etc. Contains PS00216 Sugar transport proteins signature 1. Could be termed P55. Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al.%2C2000).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00216;locus_tag=Rv1410c;product=Aminoglycosides/tetracycline-transport integral membrane protein;protein_id=CCP44169.1;transl_table=11
AL123456.3	EMBL	gene	1587772	1588482	.	-	.	ID=gene-Rv1411c;Name=lprG;gbkey=Gene;gene=lprG;gene_biotype=protein_coding;gene_synonym=P27;locus_tag=Rv1411c
AL123456.3	EMBL	CDS	1587772	1588482	.	-	0	ID=cds-CCP44170.1;Parent=gene-Rv1411c;Dbxref=EnsemblGenomes-Gn:Rv1411c,EnsemblGenomes-Tr:CCP44170,GOA:P9WK45,InterPro:IPR009830,InterPro:IPR029046,PDB:3MH8,PDB:3MH9,PDB:3MHA,NCBI_GP:CCP44170.1;Name=CCP44170.1;Note=Rv1411c%2C (MTCY21B4.28c)%2C len: 236 aa. lprG (alternate gene name: P27)%2C conserved lipoprotein%2C similar to Mycobacterium tuberculosis hypothetical lipoproteins e.g. Rv1270c|MTCY50.12 (35.1%25 identity in 245 aa overlap)%3B Rv1368%2C Rv2945c. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Note that the Rv1410c-Rv1411c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al.%2C 2000). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprG;locus_tag=Rv1411c;product=Conserved lipoprotein LprG;protein_id=CCP44170.1;transl_table=11
AL123456.3	EMBL	gene	1588567	1589172	.	+	.	ID=gene-Rv1412;Name=ribC;gbkey=Gene;gene=ribC;gene_biotype=protein_coding;locus_tag=Rv1412
AL123456.3	EMBL	CDS	1588567	1589172	.	+	0	ID=cds-CCP44171.1;Parent=gene-Rv1412;Dbxref=EnsemblGenomes-Gn:Rv1412,EnsemblGenomes-Tr:CCP44171,GOA:P9WK35,InterPro:IPR001783,InterPro:IPR017938,InterPro:IPR023366,InterPro:IPR026017,NCBI_GP:CCP44171.1;Name=CCP44171.1;Note=Rv1412%2C (MTCY21B4.29)%2C len: 201 aa. Probable ribC (ribE)%2C Riboflavin synthase alpha chain%2C strong similarity to e.g. RISA_ACTPL|P50854 (215 aa)%2C FASTA scores: opt: 586%2CE(): 1.8e-33%2C (50.8%25 identity in 197 aa overlap). Contains 2 x PS00693 Riboflavin synthase alpha chain family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ribC;inference=protein motif:PROSITE:PS00693;locus_tag=Rv1412;product=Probable riboflavin synthase alpha chain RibC (RibE);protein_id=CCP44171.1;transl_table=11
AL123456.3	EMBL	gene	1589386	1589901	.	+	.	ID=gene-Rv1413;Name=Rv1413;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1413
AL123456.3	EMBL	CDS	1589386	1589901	.	+	0	ID=cds-CCP44172.1;Parent=gene-Rv1413;Dbxref=EnsemblGenomes-Gn:Rv1413,EnsemblGenomes-Tr:CCP44172,InterPro:IPR001608,InterPro:IPR029066,NCBI_GP:CCP44172.1;Name=CCP44172.1;Note=Rv1413%2C (MTCY21B4.30)%2C len: 171 aa. Conserved hypothetical protein%2C similar to part of AB010956|AB010956_1 metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa)%2C FASTA scores: opt: 187%2C E(): 0.00026%2C (29.0%25 identity in 162 aa overlap).;gbkey=CDS;locus_tag=Rv1413;product=Conserved hypothetical protein;protein_id=CCP44172.1;transl_table=11
AL123456.3	EMBL	gene	1589891	1590292	.	+	.	ID=gene-Rv1414;Name=Rv1414;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1414
AL123456.3	EMBL	CDS	1589891	1590292	.	+	0	ID=cds-CCP44173.1;Parent=gene-Rv1414;Dbxref=EnsemblGenomes-Gn:Rv1414,EnsemblGenomes-Tr:CCP44173,InterPro:IPR026956,NCBI_GP:CCP44173.1;Name=CCP44173.1;Note=Rv1414%2C (MTCY21B4.31)%2C len: 133 aa. Conserved hypothetical protein%2C similar to C-terminal part of AB010956|AB010956_1 novel metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa)%2C FASTA scores: opt: 163%2CE(): 0.00063%2C (32.1%25 identity in 112 aa overlap). Rv1413 is similar to N-terminal part of same enzyme suggesting possible frameshift. Sequence has been checked and no errors found%2C it is identical in Mycobacterium bovis strain AF2122/97 and in Mycobacterium tuberculosis CDC1551.;gbkey=CDS;locus_tag=Rv1414;product=Conserved hypothetical protein;protein_id=CCP44173.1;transl_table=11
AL123456.3	EMBL	gene	1590397	1591674	.	+	.	ID=gene-Rv1415;Name=ribA2;gbkey=Gene;gene=ribA2;gene_biotype=protein_coding;locus_tag=Rv1415
AL123456.3	EMBL	CDS	1590397	1591674	.	+	0	ID=cds-CCP44174.1;Parent=gene-Rv1415;Dbxref=EnsemblGenomes-Gn:Rv1415,EnsemblGenomes-Tr:CCP44174,GOA:P9WHF1,InterPro:IPR000422,InterPro:IPR000926,InterPro:IPR016299,InterPro:IPR017945,NCBI_GP:CCP44174.1;Name=CCP44174.1;Note=Rv1415%2C (MTCY21B4.33)%2C len: 425 aa. Probable ribA2%2CRiboflavin biosynthesis protein%2C similar to many e.g. GCH2_BACSU|P17620 Bacillus subtilis (398 aa)%2C FASTA scores: opt: 1388%2C E(): 0%2C (55.4%25 identity in 399 aa overlap). Also similar to second Mycobacterium tuberculosis gtp cyclohydrolase Rv1940|ribA1 (353 aa). In the N-terminal section%3B belongs to the DHBP synthase family. In the C-terminal section%3B belongs to the GTP cyclohydrolase II family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ribA2;locus_tag=Rv1415;product=Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3%2C4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase);protein_id=CCP44174.1;transl_table=11
AL123456.3	EMBL	gene	1591671	1592153	.	+	.	ID=gene-Rv1416;Name=ribH;gbkey=Gene;gene=ribH;gene_biotype=protein_coding;locus_tag=Rv1416
AL123456.3	EMBL	CDS	1591671	1592153	.	+	0	ID=cds-CCP44175.1;Parent=gene-Rv1416;Dbxref=EnsemblGenomes-Gn:Rv1416,EnsemblGenomes-Tr:CCP44175,GOA:P9WHE9,InterPro:IPR002180,PDB:1W19,PDB:1W29,PDB:2C92,PDB:2C94,PDB:2C97,PDB:2C9B,PDB:2C9D,PDB:2VI5,NCBI_GP:CCP44175.1;Name=CCP44175.1;Note=Rv1416%2C (MTCY21B4.34)%2C len: 160 aa. Probable ribH%2Criboflavin synthase beta chain%2C similar to many e.g. RISB_ECOLI|P25540 Escherichia coli (156 aa)%2C FASTA scores: opt: 330%2C E(): 1.8e-15%2C (44.1%25 identity in 145 aa overlap). Note alternative GTG start possible overlapping the stop codon of Rv1415|MTCY21B4.33. Belongs to the DMRL synthase family. N-terminus extended since first submission (previously 154 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ribH;locus_tag=Rv1416;product=Probable riboflavin synthase beta chain RibH (6%2C7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase);protein_id=CCP44175.1;transl_table=11
AL123456.3	EMBL	gene	1592150	1592614	.	+	.	ID=gene-Rv1417;Name=Rv1417;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1417
AL123456.3	EMBL	CDS	1592150	1592614	.	+	0	ID=cds-CCP44176.1;Parent=gene-Rv1417;Dbxref=EnsemblGenomes-Gn:Rv1417,EnsemblGenomes-Tr:CCP44176,GOA:P9WLY1,InterPro:IPR019692,NCBI_GP:CCP44176.1;Name=CCP44176.1;Note=Rv1417%2C (MTCY21B4.35)%2C len: 154 aa. Possible conserved membrane protein%2C similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa)%2C FASTA scores: opt: 212%2C E(): 4.4e-07%2C (32.4%25 identity in 136 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1417;product=Possible conserved membrane protein;protein_id=CCP44176.1;transl_table=11
AL123456.3	EMBL	gene	1592639	1593325	.	+	.	ID=gene-Rv1418;Name=lprH;gbkey=Gene;gene=lprH;gene_biotype=protein_coding;locus_tag=Rv1418
AL123456.3	EMBL	CDS	1592639	1593325	.	+	0	ID=cds-CCP44177.1;Parent=gene-Rv1418;Dbxref=EnsemblGenomes-Gn:Rv1418,EnsemblGenomes-Tr:CCP44177,GOA:P9WK43,InterPro:IPR026954,NCBI_GP:CCP44177.1;Name=CCP44177.1;Note=Rv1418%2C (MTCY21B4.36)%2C len: 228 aa. Probable lprH%2Clipoprotein. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprH;locus_tag=Rv1418;product=Probable lipoprotein LprH;protein_id=CCP44177.1;transl_table=11
AL123456.3	EMBL	gene	1593505	1593978	.	+	.	ID=gene-Rv1419;Name=Rv1419;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1419
AL123456.3	EMBL	CDS	1593505	1593978	.	+	0	ID=cds-CCP44178.1;Parent=gene-Rv1419;Dbxref=EnsemblGenomes-Gn:Rv1419,EnsemblGenomes-Tr:CCP44178,GOA:P9WLX9,InterPro:IPR000772,NCBI_GP:CCP44178.1;Name=CCP44178.1;Note=Rv1419%2C (MTCY21B4.37)%2C len: 157 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1419;product=Unknown protein;protein_id=CCP44178.1;transl_table=11
AL123456.3	EMBL	gene	1594042	1595982	.	+	.	ID=gene-Rv1420;Name=uvrC;gbkey=Gene;gene=uvrC;gene_biotype=protein_coding;locus_tag=Rv1420
AL123456.3	EMBL	CDS	1594042	1595982	.	+	0	ID=cds-CCP44179.1;Parent=gene-Rv1420;Dbxref=EnsemblGenomes-Gn:Rv1420,EnsemblGenomes-Tr:CCP44179,GOA:P9WFC5,InterPro:IPR000305,InterPro:IPR001162,InterPro:IPR001943,InterPro:IPR003583,InterPro:IPR004791,InterPro:IPR010994,InterPro:IPR027299,NCBI_GP:CCP44179.1;Name=CCP44179.1;Note=Rv1420%2C (MTCY21B4.38)%2C len: 646 aa. Probable uvrC%2Cexcinuclease ABC%2C subunit C%3B nuclease (see citations below)%2C similar to many e.g. UVRC_PSEFL|P32966 Pseudomonas fluorescens (607 aa)%2C fasta scores: opt: 738%2C E(): 8.4e-39%2C(36.6%25 identity in 629 aa overlap). Belongs to the UvrC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=uvrC;locus_tag=Rv1420;product=Probable excinuclease ABC (subunit C-nuclease) UvrC;protein_id=CCP44179.1;transl_table=11
AL123456.3	EMBL	gene	1595979	1596884	.	+	.	ID=gene-Rv1421;Name=Rv1421;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1421
AL123456.3	EMBL	CDS	1595979	1596884	.	+	0	ID=cds-CCP44180.1;Parent=gene-Rv1421;Dbxref=EnsemblGenomes-Gn:Rv1421,EnsemblGenomes-Tr:CCP44180,GOA:P9WFQ3,InterPro:IPR005337,InterPro:IPR027417,NCBI_GP:CCP44180.1;Name=CCP44180.1;Note=Rv1421%2C (MTCY21B4.39)%2C len: 301 aa. Conserved protein%2C similar to many hypothetical proteins e.g. YHBJ_ECOLI|P33995 hypothetical 32.5 kd protein from Escherichia coli (284 aa)%2C FASTA scores: opt: 648%2C E(): 6.3e-36%2C (38.7%25 identity in 282aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1421;product=Conserved protein;protein_id=CCP44180.1;transl_table=11
AL123456.3	EMBL	gene	1596881	1597909	.	+	.	ID=gene-Rv1422;Name=Rv1422;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1422
AL123456.3	EMBL	CDS	1596881	1597909	.	+	0	ID=cds-CCP44181.1;Parent=gene-Rv1422;Dbxref=EnsemblGenomes-Gn:Rv1422,EnsemblGenomes-Tr:CCP44181,GOA:P9WMU5,InterPro:IPR002882,InterPro:IPR010119,NCBI_GP:CCP44181.1;Name=CCP44181.1;Note=Rv1422%2C (MTCY21B4.40)%2C len: 342 aa. Conserved hypothetical protein%2C similar to many hypothetical proteins e.g. YAMB_THETU|P38541 Thermoanaerobacterium thermosulfurigenes (323 aa)%2C FASTA scores: opt: 519%2C E(): 1.6e-25%2C (33.1%25 identity in 320 aa overlap)%3B and AF106003|AF106003_3 Streptomyces coelicolor (363 aa)%2C FASTA scores: opt: 1047%2C E(): 0%2C (54.5%25 identity in 308 aa overlap).;gbkey=CDS;locus_tag=Rv1422;product=Conserved hypothetical protein;protein_id=CCP44181.1;transl_table=11
AL123456.3	EMBL	gene	1597906	1598883	.	+	.	ID=gene-Rv1423;Name=whiA;gbkey=Gene;gene=whiA;gene_biotype=protein_coding;locus_tag=Rv1423
AL123456.3	EMBL	CDS	1597906	1598883	.	+	0	ID=cds-CCP44182.1;Parent=gene-Rv1423;Dbxref=EnsemblGenomes-Gn:Rv1423,EnsemblGenomes-Tr:CCP44182,GOA:P9WF45,InterPro:IPR003802,InterPro:IPR018478,InterPro:IPR023054,NCBI_GP:CCP44182.1;Name=CCP44182.1;Note=Rv1423%2C (MTCY21B4.41-MTCY493.31c)%2C len: 325 aa. Putative whiA%2C transcriptional regulator%2C probably equivalent to AL035591|SCC54.10 whiA protein from Streptomyces coelicolor (328 aa)%2C FASTA scores: opt: 1505%2CE(): 0%2C (70.4%25 identity in 324 aa overlap). Also some similarity to O06975|YVCL hypothetical protein from Bacillus subtilis (316 aa)%2C FASTA scores: E(): 1.8e-0 8%2C(25.7%25 identity in 304 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=whiA;locus_tag=Rv1423;product=Probable transcriptional regulatory protein WhiA;protein_id=CCP44182.1;transl_table=11
AL123456.3	EMBL	gene	1598893	1599654	.	-	.	ID=gene-Rv1424c;Name=Rv1424c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1424c
AL123456.3	EMBL	CDS	1598893	1599654	.	-	0	ID=cds-CCP44183.1;Parent=gene-Rv1424c;Dbxref=EnsemblGenomes-Gn:Rv1424c,EnsemblGenomes-Tr:CCP44183,GOA:P9WLX7,NCBI_GP:CCP44183.1;Name=CCP44183.1;Note=Rv1424c%2C (MTCY21B4.42c%2CMTCY493.30)%2C len: 253 aa. Possible membrane protein%2C contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00402;locus_tag=Rv1424c;product=Possible membrane protein;protein_id=CCP44183.1;transl_table=11
AL123456.3	EMBL	gene	1599658	1601037	.	+	.	ID=gene-Rv1425;Name=Rv1425;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1425
AL123456.3	EMBL	CDS	1599658	1601037	.	+	0	ID=cds-CCP44184.1;Parent=gene-Rv1425;Dbxref=EnsemblGenomes-Gn:Rv1425,EnsemblGenomes-Tr:CCP44184,GOA:P9WKC1,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP44184.1;Name=CCP44184.1;Note=Rv1425%2C (MTCY21B4.43%2CMTCY493.29c)%2C len: 459 aa. Possible triacylglycerol synthase (See Daniel et al.%2C2004)%2C similar to many M. tuberculosis proteins e.g. Rv3740c%2C Rv3734c%2C Rv1760%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1425;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP44184.1;transl_table=11
AL123456.3	EMBL	gene	1601059	1602321	.	-	.	ID=gene-Rv1426c;Name=lipO;gbkey=Gene;gene=lipO;gene_biotype=protein_coding;locus_tag=Rv1426c
AL123456.3	EMBL	CDS	1601059	1602321	.	-	0	ID=cds-CCP44185.1;Parent=gene-Rv1426c;Dbxref=EnsemblGenomes-Gn:Rv1426c,EnsemblGenomes-Tr:CCP44185,GOA:O06832,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:O06832,NCBI_GP:CCP44185.1;Name=CCP44185.1;Note=Rv1426c%2C (MTCY493.28)%2C len: 420 aa. Possible lipO%2Cesterase%2C similar to several Mycobacterium tuberculosis hypothetical lipases and esterases e.g. Rv1399c%2C Rv2284%2Cetc. Also similar in central region to AAAD_HUMAN|P22760 human arylacetamide deacetylase (398 aa)%2C FASTA scores: opt:210%2C E(): 7.6e-07%2C (29.3%25 identity in 191 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipO;locus_tag=Rv1426c;product=Probable esterase LipO;protein_id=CCP44185.1;transl_table=11
AL123456.3	EMBL	gene	1602321	1603928	.	-	.	ID=gene-Rv1427c;Name=fadD12;gbkey=Gene;gene=fadD12;gene_biotype=protein_coding;locus_tag=Rv1427c
AL123456.3	EMBL	CDS	1602321	1603928	.	-	0	ID=cds-CCP44186.1;Parent=gene-Rv1427c;Dbxref=EnsemblGenomes-Gn:Rv1427c,EnsemblGenomes-Tr:CCP44186,GOA:O06831,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O06831,NCBI_GP:CCP44186.1;Name=CCP44186.1;Note=Rv1427c%2C (MTCY493.27)%2C len: 535 aa. Possible fadD12%2Clong-chain-fatty-acid-CoA synthetase%2C similar to many e.g. NP_302632.1|NC_002677 acyl-CoA synthase from Mycobacterium leprae (548 aa)%3B AAD01929.2|AF031419 putative long-chain-fatty-acid--CoA ligase from Pseudomonas putida (565 aa)%3B NP_419782.1|NC_002696 putative long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (530 aa)%3B PC60_YEAST|P38137 yeast peroxisomal-coenzyme A synthetase (543 aa)%2C FASTA scores: opt: 507%2C E(): 2.9e-25%2C (30.4%25 identity in 365 aa overlap). Also similar to many M. tuberculosis proteins e.g. MTCY06A4.14 (44.8%25 identity in 525 aa overlap). Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD12;inference=protein motif:PROSITE:PS00455;locus_tag=Rv1427c;product=Possible long-chain-fatty-acid--CoA ligase FadD12 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP44186.1;transl_table=11
AL123456.3	EMBL	gene	1603932	1604759	.	-	.	ID=gene-Rv1428c;Name=Rv1428c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1428c
AL123456.3	EMBL	CDS	1603932	1604759	.	-	0	ID=cds-CCP44187.1;Parent=gene-Rv1428c;Dbxref=EnsemblGenomes-Gn:Rv1428c,EnsemblGenomes-Tr:CCP44187,GOA:O06830,InterPro:IPR002123,InterPro:IPR016676,UniProtKB/TrEMBL:O06830,NCBI_GP:CCP44187.1;Name=CCP44187.1;Note=Rv1428c%2C (MTCY493.26)%2C len: 275 aa. Conserved hypothetical protein%2C some similarity to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0502|YV29_MYCTU|Q11167 (358 aa)%2C FASTA scores: opt: 355%2CE(): 5e-16%2C (32.6%25 identity in 273 aa overlap)%3B and Rv1920.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1428c;product=Conserved hypothetical protein;protein_id=CCP44187.1;transl_table=11
AL123456.3	EMBL	gene	1604878	1606146	.	+	.	ID=gene-Rv1429;Name=Rv1429;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1429
AL123456.3	EMBL	CDS	1604878	1606146	.	+	0	ID=cds-CCP44188.1;Parent=gene-Rv1429;Dbxref=EnsemblGenomes-Gn:Rv1429,EnsemblGenomes-Tr:CCP44188,GOA:O06829,InterPro:IPR025736,UniProtKB/TrEMBL:O06829,NCBI_GP:CCP44188.1;Name=CCP44188.1;Note=Rv1429%2C (MTCY493.25c)%2C len: 422 aa. Conserved protein%2C some similarity to transcriptional regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate diacid regulator from Escherichia coli (391 aa)%2C FASTA scores: opt: 210%2C E(): 3e-06%2C (27.7%25 identity in 296 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2370c%2C Rv1194c%2C Rv1453%2C Rv2242%2C and Rv1186c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1429;product=Conserved protein;protein_id=CCP44188.1;transl_table=11
AL123456.3	EMBL	gene	1606386	1607972	.	+	.	ID=gene-Rv1430;Name=PE16;gbkey=Gene;gene=PE16;gene_biotype=protein_coding;locus_tag=Rv1430
AL123456.3	EMBL	CDS	1606386	1607972	.	+	0	ID=cds-CCP44189.1;Parent=gene-Rv1430;Dbxref=EnsemblGenomes-Gn:Rv1430,EnsemblGenomes-Tr:CCP44189,InterPro:IPR000084,InterPro:IPR013228,InterPro:IPR029058,UniProtKB/TrEMBL:L7N697,NCBI_GP:CCP44189.1;Name=CCP44189.1;Note=Rv1430%2C (MTCY493.24c)%2C len: 528 aa. PE16%2C Member of the Mycobacterium tuberculosis PE family of proteins (see citation below)%2C e.g. Y0D4_MYCTU|Q50594 (55.9%25 identity in 127 aa overlap). The C-terminus shows similarity to Q49633|LEPB1170_F3_112 hypothetical Mycobacterium leprae protein (391 aa)%2C FASTA scores: opt: 342%2C E(): 1.2e-13%2C(29.8%25 identity in 292 aa overlap). Possible TMhelix aa 500-522.;gbkey=CDS;gene=PE16;locus_tag=Rv1430;product=PE family protein PE16;protein_id=CCP44189.1;transl_table=11
AL123456.3	EMBL	gene	1608083	1609852	.	+	.	ID=gene-Rv1431;Name=Rv1431;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1431
AL123456.3	EMBL	CDS	1608083	1609852	.	+	0	ID=cds-CCP44190.1;Parent=gene-Rv1431;Dbxref=EnsemblGenomes-Gn:Rv1431,EnsemblGenomes-Tr:CCP44190,InterPro:IPR021941,UniProtKB/TrEMBL:O06827,NCBI_GP:CCP44190.1;Name=CCP44190.1;Note=Rv1431%2C (MTCY493.23c)%2C len: 589 aa. Conserved membrane protein%2C shows strong similarity to another M. tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2%25 identity in 585 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1431;product=Conserved membrane protein;protein_id=CCP44190.1;transl_table=11
AL123456.3	EMBL	gene	1609849	1611270	.	+	.	ID=gene-Rv1432;Name=Rv1432;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1432
AL123456.3	EMBL	CDS	1609849	1611270	.	+	0	ID=cds-CCP44191.1;Parent=gene-Rv1432;Dbxref=EnsemblGenomes-Gn:Rv1432,EnsemblGenomes-Tr:CCP44191,UniProtKB/TrEMBL:O06826,NCBI_GP:CCP44191.1;Name=CCP44191.1;Note=Rv1432%2C (MTCY493.22c)%2C len: 473 aa. Probable dehydrogenase%2C shows strong similarity to P49_STRLI|P06108 p49 protein from Streptomyces lividans (469 aa)%2C FASTA scores: opt: 1362%2C E(): 0%2C (44.9%25 identity in 474 aa overlap)%3B and weak similarity to other dehydrogenases.;gbkey=CDS;locus_tag=Rv1432;product=Probable dehydrogenase;protein_id=CCP44191.1;transl_table=11
AL123456.3	EMBL	gene	1611434	1612249	.	+	.	ID=gene-Rv1433;Name=Rv1433;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1433
AL123456.3	EMBL	CDS	1611434	1612249	.	+	0	ID=cds-CCP44192.1;Parent=gene-Rv1433;Dbxref=EnsemblGenomes-Gn:Rv1433,EnsemblGenomes-Tr:CCP44192,GOA:O06825,InterPro:IPR005490,PDB:4K73,NCBI_GP:CCP44192.1;Name=CCP44192.1;Note=Rv1433%2C (MTCY493.21c)%2C len: 271 aa. Possible exported protein with N-terminal signal sequence%2C highly similar to Q49706 hypothetical protein from Mycobacterium leprae (271 aa)%2C FASTA scores: opt: 1341%2C E(): 0%2C (68.3%25 identity in 271 aa overlap). Also shows similarity to M. tuberculosis lipoprotein Rv2518c|MTV009.03c lppS (408 aa) (40.0%25 identity in 230 aa overlap)%3B and others e.g. Rv0116c%2C Rv0192%2C Rv2518c%2C Rv0483. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1433;product=Possible conserved exported protein;protein_id=CCP44192.1;transl_table=11
AL123456.3	EMBL	gene	1612256	1612393	.	+	.	ID=gene-Rv1434;Name=Rv1434;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1434
AL123456.3	EMBL	CDS	1612256	1612393	.	+	0	ID=cds-CCP44193.1;Parent=gene-Rv1434;Dbxref=EnsemblGenomes-Gn:Rv1434,EnsemblGenomes-Tr:CCP44193,UniProtKB/TrEMBL:O06824,NCBI_GP:CCP44193.1;Name=CCP44193.1;Note=Rv1434%2C (MTCY493.20c)%2C len: 45 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1434;product=Hypothetical protein;protein_id=CCP44193.1;transl_table=11
AL123456.3	EMBL	gene	1612342	1612950	.	-	.	ID=gene-Rv1435c;Name=Rv1435c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1435c
AL123456.3	EMBL	CDS	1612342	1612950	.	-	0	ID=cds-CCP44194.1;Parent=gene-Rv1435c;Dbxref=EnsemblGenomes-Gn:Rv1435c,EnsemblGenomes-Tr:CCP44194,GOA:O06823,UniProtKB/TrEMBL:O06823,NCBI_GP:CCP44194.1;Name=CCP44194.1;Note=Rv1435c%2C (MTCY493.19)%2C len: 202 aa. Probable conserved Pro-%2C Gly-%2C Val-rich secreted protein (see citation below) with a N-terminal signal sequence. Similar at C-terminus to AF017099|AF017099_1 Mycobacterium tuberculosis pGB1 (87 aa)%2C FASTA scores: opt: 550%2C E(): 2.3e-17%2C (97.7%25 identity in 86 aa overlap). Shows some similarity to N-terminus of CPN_DROME|Q02910 calphotin. Drosophila melanogaster (865 aa)%2C FASTA scores: opt: 266%2CE(): 2.5e-05%2C (37.2%25 identity in 191 aa overlap). Contains at least five 7 aa imperfect repeats. Also shows similarity to other Mycobacterium tuberculosis proteins e.g. MTCI237.20c (34.7%25 identity in 193 aa overlap)%2C MTCI65.25c (36.9%25 identity in 160 aa overlap) and MTCI65.24c (34.2%25 identity in 196 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1435c;product=Probable conserved proline%2C glycine%2C valine-rich secreted protein;protein_id=CCP44194.1;transl_table=11
AL123456.3	EMBL	repeat_region	1612558	1612578	.	-	.	ID=id-Rv1435c;Note=21 bp imperfect direct repeat 5%2CGGCGCACCGGTACCGGTACCC;gbkey=repeat_region;locus_tag=Rv1435c
AL123456.3	EMBL	repeat_region	1612579	1612599	.	-	.	ID=id-Rv1435c-2;Note=21 bp imperfect direct repeat 4%2CGGCGGACCGGTACCGATACCG;gbkey=repeat_region;locus_tag=Rv1435c
AL123456.3	EMBL	repeat_region	1612600	1612620	.	-	.	ID=id-Rv1435c-3;Note=21 bp imperfect direct repeat 3%2CGGCGCACCGGTACCAATCCCC;gbkey=repeat_region;locus_tag=Rv1435c
AL123456.3	EMBL	repeat_region	1612621	1612641	.	-	.	ID=id-Rv1435c-4;Note=21 bp imperfect direct repeat 2%2CGGCGCACCGGTACCGATACCG;gbkey=repeat_region;locus_tag=Rv1435c
AL123456.3	EMBL	repeat_region	1612642	1612662	.	-	.	ID=id-Rv1435c-5;Note=21 bp imperfect direct repeat 1%2CGGCGCACCGGTACCAATCCCT;gbkey=repeat_region;locus_tag=Rv1435c
AL123456.3	EMBL	gene	1613307	1614326	.	+	.	ID=gene-Rv1436;Name=gap;gbkey=Gene;gene=gap;gene_biotype=protein_coding;locus_tag=Rv1436
AL123456.3	EMBL	CDS	1613307	1614326	.	+	0	ID=cds-CCP44195.1;Parent=gene-Rv1436;Dbxref=EnsemblGenomes-Gn:Rv1436,EnsemblGenomes-Tr:CCP44195,GOA:P9WN83,InterPro:IPR006424,InterPro:IPR016040,InterPro:IPR020828,InterPro:IPR020829,InterPro:IPR020830,InterPro:IPR020831,NCBI_GP:CCP44195.1;Name=CCP44195.1;Note=Rv1436%2C (MTCY493.18c)%2C len: 339 aa. Probable gap%2CGlyceraldehyde 3-phosphate dehydrogenase%2C highly similar to many e.g. G3P_MYCLE|P46713 Mycobacterium leprae (339 aa)%2CFASTA scores: opt: 1933%2C E():0%2C (89.1%25 identity in 339 aa overlap). Contains PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. Belongs to the glyceraldehyde 3-phosphate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gap;inference=protein motif:PROSITE:PS00071;locus_tag=Rv1436;product=Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH);protein_id=CCP44195.1;transl_table=11
AL123456.3	EMBL	gene	1614329	1615567	.	+	.	ID=gene-Rv1437;Name=pgk;gbkey=Gene;gene=pgk;gene_biotype=protein_coding;locus_tag=Rv1437
AL123456.3	EMBL	CDS	1614329	1615567	.	+	0	ID=cds-CCP44196.1;Parent=gene-Rv1437;Dbxref=EnsemblGenomes-Gn:Rv1437,EnsemblGenomes-Tr:CCP44196,GOA:P9WID1,InterPro:IPR001576,InterPro:IPR015824,InterPro:IPR015901,InterPro:IPR015911,NCBI_GP:CCP44196.1;Name=CCP44196.1;Note=Rv1437%2C (MTCY493.17c)%2C len: 412 aa. Probable pgk%2CPhosphoglycerate kinase%2C highly similar to many e.g. PGK_MYCLE|P46712 Mycobacterium leprae (416 aa)%2C FASTA scores: opt: 2153%2C E(): 0%2C (80.4%25 identity in 414 aa overlap). Contains PS00111 Phosphoglycerate kinase signature. Belongs to the phosphoglycerate kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pgk;inference=protein motif:PROSITE:PS00111;locus_tag=Rv1437;product=Probable phosphoglycerate kinase Pgk;protein_id=CCP44196.1;transl_table=11
AL123456.3	EMBL	gene	1615564	1616349	.	+	.	ID=gene-Rv1438;Name=tpi;gbkey=Gene;gene=tpi;gene_biotype=protein_coding;locus_tag=Rv1438
AL123456.3	EMBL	CDS	1615564	1616349	.	+	0	ID=cds-CCP44197.1;Parent=gene-Rv1438;Dbxref=EnsemblGenomes-Gn:Rv1438,EnsemblGenomes-Tr:CCP44197,GOA:P9WG43,InterPro:IPR000652,InterPro:IPR013785,InterPro:IPR020861,InterPro:IPR022896,PDB:3GVG,PDB:3TA6,PDB:3TAO,NCBI_GP:CCP44197.1;Name=CCP44197.1;Note=Rv1438%2C (MTCY493.16c)%2C len: 261 aa. Probable tpi (tpiA)%2C Triosephosphate isomerase%2C highly similar to many e.g. TPIS_MYCLE|P46711 Mycobacterium leprae (261 aa)%2C FASTA scores: opt: 1456%2C E(): 0%2C (83.9%25 identity in 261 aa overlap). Contains PS00171 Triosephosphate isomerase active site. Belongs to the triosephosphate isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tpi;inference=protein motif:PROSITE:PS00171;locus_tag=Rv1438;product=Probable triosephosphate isomerase Tpi (TIM);protein_id=CCP44197.1;transl_table=11
AL123456.3	EMBL	gene	1616961	1617386	.	-	.	ID=gene-Rv1439c;Name=Rv1439c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1439c
AL123456.3	EMBL	CDS	1616961	1617386	.	-	0	ID=cds-CCP44198.1;Parent=gene-Rv1439c;Dbxref=EnsemblGenomes-Gn:Rv1439c,EnsemblGenomes-Tr:CCP44198,InterPro:IPR009959,UniProtKB/TrEMBL:O06820,NCBI_GP:CCP44198.1;Name=CCP44198.1;Note=Rv1439c%2C (MTCY493.15)%2C len: 141 aa. Unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1439c;product=Unknown protein;protein_id=CCP44198.1;transl_table=11
AL123456.3	EMBL	gene	1617837	1618070	.	+	.	ID=gene-Rv1440;Name=secG;gbkey=Gene;gene=secG;gene_biotype=protein_coding;locus_tag=Rv1440
AL123456.3	EMBL	CDS	1617837	1618070	.	+	0	ID=cds-CCP44199.1;Parent=gene-Rv1440;Dbxref=EnsemblGenomes-Gn:Rv1440,EnsemblGenomes-Tr:CCP44199,GOA:P9WGN5,InterPro:IPR004692,NCBI_GP:CCP44199.1;Name=CCP44199.1;Note=Rv1440%2C (MTCY493.14c)%2C len: 77 aa. Probable secG%2Cprotein-export membrane protein (translocase subunit) (see citation below)%2C similar to many e.g. P38388|SECG_MYCLE probable protein-export membrane (77 aa)%2C FASTA scores: opt: 450%2C E(): 6.7e-24%2C (96.1%25 identity in 77 aa overlap). Start changed since original submission (-40 aa). Part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c%2C SECD|Rv2587c%2C SECE|Rv0638%2CSECF|Rv2586c%2C SECG and SECY|Rv0732.;gbkey=CDS;gene=secG;locus_tag=Rv1440;product=Probable protein-export membrane protein (translocase subunit) SecG;protein_id=CCP44199.1;transl_table=11
AL123456.3	EMBL	gene	1618209	1619684	.	-	.	ID=gene-Rv1441c;Name=PE_PGRS26;gbkey=Gene;gene=PE_PGRS26;gene_biotype=protein_coding;locus_tag=Rv1441c
AL123456.3	EMBL	CDS	1618209	1619684	.	-	0	ID=cds-CCP44200.1;Parent=gene-Rv1441c;Dbxref=EnsemblGenomes-Gn:Rv1441c,EnsemblGenomes-Tr:CCP44200,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FP3,NCBI_GP:CCP44200.1;Name=CCP44200.1;Note=Rv1441c%2C (MTCY493.13)%2C len: 491 aa. PE_PGRS26%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002)%2Csimilar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa)%2C fasta scores: opt: 1625%2C E(): 0%2C(55.2%25 identity in 518 aa overlap).;gbkey=CDS;gene=PE_PGRS26;locus_tag=Rv1441c;product=PE-PGRS family protein PE_PGRS26;protein_id=CCP44200.1;transl_table=11
AL123456.3	EMBL	gene	1619791	1622091	.	+	.	ID=gene-Rv1442;Name=bisC;gbkey=Gene;gene=bisC;gene_biotype=protein_coding;locus_tag=Rv1442
AL123456.3	EMBL	CDS	1619791	1622091	.	+	0	ID=cds-CCP44201.1;Parent=gene-Rv1442;Dbxref=EnsemblGenomes-Gn:Rv1442,EnsemblGenomes-Tr:CCP44201,GOA:O06817,InterPro:IPR006656,InterPro:IPR006657,InterPro:IPR006658,InterPro:IPR009010,UniProtKB/TrEMBL:O06817,NCBI_GP:CCP44201.1;Name=CCP44201.1;Note=Rv1442%2C (MTCY493.12c)%2C len: 766 aa. Probable bisC%2CBiotin sulfoxide reductase%2C similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa)%2CFASTA scores: opt: 1271%2C E():0%2C (40.2%25 identity in 744 aa overlap).;gbkey=CDS;gene=bisC;locus_tag=Rv1442;product=Probable biotin sulfoxide reductase BisC (BDS reductase) (BSO reductase);protein_id=CCP44201.1;transl_table=11
AL123456.3	EMBL	gene	1622207	1622692	.	-	.	ID=gene-Rv1443c;Name=Rv1443c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1443c
AL123456.3	EMBL	CDS	1622207	1622692	.	-	0	ID=cds-CCP44202.1;Parent=gene-Rv1443c;Dbxref=EnsemblGenomes-Gn:Rv1443c,EnsemblGenomes-Tr:CCP44202,GOA:O06816,InterPro:IPR019587,InterPro:IPR023393,UniProtKB/TrEMBL:O06816,NCBI_GP:CCP44202.1;Name=CCP44202.1;Note=Rv1443c%2C (MTCY493.11)%2C len: 161 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1443c;product=Unknown protein;protein_id=CCP44202.1;transl_table=11
AL123456.3	EMBL	gene	1623287	1623697	.	-	.	ID=gene-Rv1444c;Name=Rv1444c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1444c
AL123456.3	EMBL	CDS	1623287	1623697	.	-	0	ID=cds-CCP44203.1;Parent=gene-Rv1444c;Dbxref=EnsemblGenomes-Gn:Rv1444c,EnsemblGenomes-Tr:CCP44203,InterPro:IPR022788,UniProtKB/TrEMBL:O06815,NCBI_GP:CCP44203.1;Name=CCP44203.1;Note=Rv1444c%2C (MTCY493.10)%2C len: 136 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1444c;product=Unknown protein;protein_id=CCP44203.1;transl_table=11
AL123456.3	EMBL	gene	1623714	1624457	.	-	.	ID=gene-Rv1445c;Name=devB;gbkey=Gene;gene=devB;gene_biotype=protein_coding;locus_tag=Rv1445c
AL123456.3	EMBL	CDS	1623714	1624457	.	-	0	ID=cds-CCP44204.1;Parent=gene-Rv1445c;Dbxref=EnsemblGenomes-Gn:Rv1445c,EnsemblGenomes-Tr:CCP44204,GOA:P9WQP5,InterPro:IPR005900,InterPro:IPR006148,PDB:3ICO,NCBI_GP:CCP44204.1;Name=CCP44204.1;Note=Rv1445c%2C (MTCY493.09)%2C len: 247 aa. Possible devB (PGL)%2C 6-phosphogluconolactonase%2C belongs to a different family to the upstream gene zwf2. Similar to e.g. DEVB_ANASP|P46016 putative glucose-6-phosphate 1-dehydrogenase (239 aa)%2C FASTA scores: opt: 439%2C E(): 2.6e-20%2C (34.0%25 identity in 247 aa overlap). Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=devB;locus_tag=Rv1445c;product=Probable 6-phosphogluconolactonase DevB (6PGL);protein_id=CCP44204.1;transl_table=11
AL123456.3	EMBL	gene	1624454	1625365	.	-	.	ID=gene-Rv1446c;Name=opcA;gbkey=Gene;gene=opcA;gene_biotype=protein_coding;locus_tag=Rv1446c
AL123456.3	EMBL	CDS	1624454	1625365	.	-	0	ID=cds-CCP44205.1;Parent=gene-Rv1446c;Dbxref=EnsemblGenomes-Gn:Rv1446c,EnsemblGenomes-Tr:CCP44205,GOA:O06813,InterPro:IPR004555,UniProtKB/TrEMBL:O06813,NCBI_GP:CCP44205.1;Name=CCP44205.1;Note=Rv1446c%2C (MTCY493.08)%2C len: 303 aa. Putative opcA%2COxPP cycle protein. Highly similar to S72774 B1496_F1_30 protein from Mycobacterium leprae (265 aa)%2C FASTA scores: opt: 1056%2C E(): 0%2C (70.3%25 identity in 239 aa overlap). Also similar to OPCA_NOSS2|P48971 putative oxppcycle protein opca from Nostoc punctiforme (465 aa)%2C fasta scores: opt: 177%2C E(): 7.3e-05%2C (23.4%25 identity in 321 aa overlap). Aids in G6PD activity.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=opcA;locus_tag=Rv1446c;product=Putative OXPP cycle protein OpcA;protein_id=CCP44205.1;transl_table=11
AL123456.3	EMBL	repeat_region	1625366	1625418	.	-	.	ID=id-AL123456.3:1625366..1625418;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	1625418	1626962	.	-	.	ID=gene-Rv1447c;Name=zwf2;gbkey=Gene;gene=zwf2;gene_biotype=protein_coding;locus_tag=Rv1447c
AL123456.3	EMBL	CDS	1625418	1626962	.	-	0	ID=cds-CCP44206.1;Parent=gene-Rv1447c;Dbxref=EnsemblGenomes-Gn:Rv1447c,EnsemblGenomes-Tr:CCP44206,GOA:P9WN73,InterPro:IPR001282,InterPro:IPR016040,InterPro:IPR019796,InterPro:IPR022674,InterPro:IPR022675,NCBI_GP:CCP44206.1;Name=CCP44206.1;Note=Rv1447c%2C (MTCY493.07)%2C len: 514 aa. Probable zwf2 (ZWF)%2C Glucose-6-phosphate 1-dehydrogenase%2C highly similar to many e.g. G6PD_SYNY3|P73411 Synechocystis sp. (509 aa)%2CFASTA scores: opt: 1578%2C E(): 0%2C (46.8%25 identity in 509 aa overlap). Also similar to M. tuberculosis Rv1121%2C zwf glucose-6-phosphate 1-dehydrogenase. Contains PS00069 Glucose-6-phosphate dehydrogenase active site. Mycobacterium tuberculosis has two genes for ZWF. This one looks like a classical ZWF. Belongs to the glucose-6-phosphate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=zwf2;inference=protein motif:PROSITE:PS00069;locus_tag=Rv1447c;product=Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD);protein_id=CCP44206.1;transl_table=11
AL123456.3	EMBL	gene	1626959	1628080	.	-	.	ID=gene-Rv1448c;Name=tal;gbkey=Gene;gene=tal;gene_biotype=protein_coding;locus_tag=Rv1448c
AL123456.3	EMBL	CDS	1626959	1628080	.	-	0	ID=cds-CCP44207.1;Parent=gene-Rv1448c;Dbxref=EnsemblGenomes-Gn:Rv1448c,EnsemblGenomes-Tr:CCP44207,GOA:P9WG33,InterPro:IPR001585,InterPro:IPR004732,InterPro:IPR013785,InterPro:IPR018225,NCBI_GP:CCP44207.1;Name=CCP44207.1;Note=Rv1448c%2C (MTCY493.06)%2C len: 373 aa. Probable tal%2CTransaldolase%2C highly similar to many e.g. TAL_MYCLE|P55193 transaldolase from Mycobacterium leprae (375 aa)%2C FASTA scores: opt: 1891%2C E(): 0%2C (78.6%25 identity in 370 aa overlap). Belongs to the transaldolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tal;locus_tag=Rv1448c;product=Probable transaldolase Tal;protein_id=CCP44207.1;transl_table=11
AL123456.3	EMBL	gene	1628097	1630199	.	-	.	ID=gene-Rv1449c;Name=tkt;gbkey=Gene;gene=tkt;gene_biotype=protein_coding;locus_tag=Rv1449c
AL123456.3	EMBL	CDS	1628097	1630199	.	-	0	ID=cds-CCP44208.1;Parent=gene-Rv1449c;Dbxref=EnsemblGenomes-Gn:Rv1449c,EnsemblGenomes-Tr:CCP44208,GOA:P9WG25,InterPro:IPR005474,InterPro:IPR005475,InterPro:IPR005476,InterPro:IPR005478,InterPro:IPR009014,InterPro:IPR020826,InterPro:IPR029061,PDB:3RIM,NCBI_GP:CCP44208.1;Name=CCP44208.1;Note=Rv1449c%2C (MTCY493.05)%2C len: 700 aa. tkt%2Ctransketolase. Highly similar to several e.g. TKT_MYCLE|P46708 transketolase (tk) from Mycobacterium leprae (699 aa)%2C FASTA scores: opt: 4216%2C E(): 0%2C (89.1%25 identity in 700 aa overlap). Start site chosen by homology. Contains PS00801 Transketolase signature 1. Belongs to the transketolase family. Thought to be differentially expressed within host cells (see Triccas et al.%2C 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tkt;inference=protein motif:PROSITE:PS00801;locus_tag=Rv1449c;product=Transketolase Tkt (TK);protein_id=CCP44208.1;transl_table=11
AL123456.3	EMBL	gene	1630638	1634627	.	-	.	ID=gene-Rv1450c;Name=PE_PGRS27;gbkey=Gene;gene=PE_PGRS27;gene_biotype=protein_coding;locus_tag=Rv1450c
AL123456.3	EMBL	CDS	1630638	1634627	.	-	0	ID=cds-CCP44209.1;Parent=gene-Rv1450c;Dbxref=EnsemblGenomes-Gn:Rv1450c,EnsemblGenomes-Tr:CCP44209,GOA:Q79FP2,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FP2,NCBI_GP:CCP44209.1;Name=CCP44209.1;Note=Rv1450c%2C (MTCY493.04)%2C len: 1329 aa. PE_PGRS27%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C2002)%2C similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa)%2C fasta scores: opt: 2112%2C E(): 0%2C (56.5%25 identity in 630 aa overlap).;gbkey=CDS;gene=PE_PGRS27;locus_tag=Rv1450c;product=PE-PGRS family protein PE_PGRS27;protein_id=CCP44209.1;transl_table=11
AL123456.3	EMBL	repeat_region	1633531	1634790	.	-	.	ID=id-AL123456.3:1633531..1634790;Note=1260 bp imperfect direct repeat 2%2C first copy at 1637133..1638392;gbkey=repeat_region
AL123456.3	EMBL	gene	1635029	1635955	.	+	.	ID=gene-Rv1451;Name=ctaB;gbkey=Gene;gene=ctaB;gene_biotype=protein_coding;locus_tag=Rv1451
AL123456.3	EMBL	CDS	1635029	1635955	.	+	0	ID=cds-CCP44210.1;Parent=gene-Rv1451;Dbxref=EnsemblGenomes-Gn:Rv1451,EnsemblGenomes-Tr:CCP44210,GOA:P9WFR7,InterPro:IPR000537,InterPro:IPR006369,NCBI_GP:CCP44210.1;Name=CCP44210.1;Note=Rv1451%2C (MTCY493.03c)%2C len: 308 aa. Probable ctaB%2Ccytochrome C oxidase assembly factor%2C and integral membrane protein. Highly similar to several Mycobacterium leprae proteins e.g. Q49685 CYOE cytochrome O ubiquinol oxidase assembly factor (300 aa)%2C FASTA scores: opt: 1636%2C E(): 0%2C(82.7%25 identity in 307 aa overlap)%3B NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa)%3B NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa).;gbkey=CDS;gene=ctaB;locus_tag=Rv1451;product=Probable cytochrome C oxidase assembly factor CtaB;protein_id=CCP44210.1;transl_table=11
AL123456.3	EMBL	gene	1636004	1638229	.	-	.	ID=gene-Rv1452c;Name=PE_PGRS28;gbkey=Gene;gene=PE_PGRS28;gene_biotype=protein_coding;locus_tag=Rv1452c
AL123456.3	EMBL	CDS	1636004	1638229	.	-	0	ID=cds-CCP44211.1;Parent=gene-Rv1452c;Dbxref=EnsemblGenomes-Gn:Rv1452c,EnsemblGenomes-Tr:CCP44211,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FP1,NCBI_GP:CCP44211.1;Name=CCP44211.1;Note=Rv1452c%2C (MTCY493.02)%2C len: 741 aa. PE_PGRS28%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C2002)%2C similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa)%2C fasta scores: opt: 2090%2C E(): 0%2C (56.3%25 identity in 641 aa overlap).;gbkey=CDS;gene=PE_PGRS28;locus_tag=Rv1452c;product=PE-PGRS family protein PE_PGRS28;protein_id=CCP44211.1;transl_table=11
AL123456.3	EMBL	repeat_region	1637133	1638392	.	-	.	ID=id-AL123456.3:1637133..1638392;Note=1260 bp imperfect direct repeat 1%2C second copy at 1633531..1634790;gbkey=repeat_region
AL123456.3	EMBL	gene	1638381	1639646	.	+	.	ID=gene-Rv1453;Name=Rv1453;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1453
AL123456.3	EMBL	CDS	1638381	1639646	.	+	0	ID=cds-CCP44212.1;Parent=gene-Rv1453;Dbxref=EnsemblGenomes-Gn:Rv1453,EnsemblGenomes-Tr:CCP44212,GOA:O06807,InterPro:IPR025736,UniProtKB/TrEMBL:O06807,NCBI_GP:CCP44212.1;Name=CCP44212.1;Note=Rv1453%2C (MTCY493.01c)%2C len: 421 aa. Possible transcriptional activator%2C similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa)%2C FASTA scores: opt: 1719%2C E(): 0%2C (54.0%25 identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c%2C Rv1194c%2C Rv2242%2C Rv1186c%2Cand to the further upstream ORF's Rv1429|MTCY493.25c (28.1%25 identity in 335 aa overlap). Start changed since first submission (-11 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1453;product=Possible transcriptional activator protein;protein_id=CCP44212.1;transl_table=11
AL123456.3	EMBL	gene	1639674	1640660	.	-	.	ID=gene-Rv1454c;Name=qor;gbkey=Gene;gene=qor;gene_biotype=protein_coding;locus_tag=Rv1454c
AL123456.3	EMBL	CDS	1639674	1640660	.	-	0	ID=cds-CCP44213.1;Parent=gene-Rv1454c;Dbxref=EnsemblGenomes-Gn:Rv1454c,EnsemblGenomes-Tr:CCP44213,GOA:O53146,InterPro:IPR002085,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,UniProtKB/TrEMBL:O53146,NCBI_GP:CCP44213.1;Name=CCP44213.1;Note=Rv1454c%2C (MTV007.01c)%2C len: 328 aa. Probable qor%2Cquinone oxidoreductase%2C simiar to U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter capsulatus (323 aa)%2C FASTA scores: opt: 849%2C E(): 0%2C (44.7%25 identity in 329 aa overlap). Also similar to MTCY180.06 Hypothetical protein from Mycobacterium tuberculosis (334 aa)%2C FASTA scores: opt: 430%2C E(): 2e-14%2C (32.3%25 identity in 350 aa overlap). Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=qor;inference=protein motif:PROSITE:PS01162;locus_tag=Rv1454c;product=Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein);protein_id=CCP44213.1;transl_table=11
AL123456.3	EMBL	gene	1640680	1641543	.	+	.	ID=gene-Rv1455;Name=Rv1455;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1455
AL123456.3	EMBL	CDS	1640680	1641543	.	+	0	ID=cds-CCP44214.1;Parent=gene-Rv1455;Dbxref=EnsemblGenomes-Gn:Rv1455,EnsemblGenomes-Tr:CCP44214,UniProtKB/TrEMBL:O53147,NCBI_GP:CCP44214.1;Name=CCP44214.1;Note=Rv1455%2C (MTV007.02)%2C len: 287 aa. Conserved protein%2Csome similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa)%2C FASTA scores: opt: 238%2C E(): 1.8e-08%2C (51.3%25 identity in 78 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1455;product=Conserved protein;protein_id=CCP44214.1;transl_table=11
AL123456.3	EMBL	gene	1641493	1642425	.	-	.	ID=gene-Rv1456c;Name=Rv1456c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1456c
AL123456.3	EMBL	CDS	1641493	1642425	.	-	0	ID=cds-CCP44215.1;Parent=gene-Rv1456c;Dbxref=EnsemblGenomes-Gn:Rv1456c,EnsemblGenomes-Tr:CCP44215,GOA:O53148,InterPro:IPR003780,UniProtKB/TrEMBL:O53148,NCBI_GP:CCP44215.1;Name=CCP44215.1;Note=Rv1456c%2C (MTV007.03c)%2C len: 310 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below)%2C equivalent to Z99125|MLCL536.34 from Mycobacterium leprae (311 aa)%2C FASTA scores: opt: 1607%2C E(): 0%2C (83.3%25 identity in 300 aa overlap).;gbkey=CDS;locus_tag=Rv1456c;product=Probable unidentified antibiotic-transport integral membrane ABC transporter;protein_id=CCP44215.1;transl_table=11
AL123456.3	EMBL	gene	1642537	1643322	.	-	.	ID=gene-Rv1457c;Name=Rv1457c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1457c
AL123456.3	EMBL	CDS	1642537	1643322	.	-	0	ID=cds-CCP44216.1;Parent=gene-Rv1457c;Dbxref=EnsemblGenomes-Gn:Rv1457c,EnsemblGenomes-Tr:CCP44216,GOA:O86349,InterPro:IPR000412,InterPro:IPR004377,UniProtKB/TrEMBL:O86349,NCBI_GP:CCP44216.1;Name=CCP44216.1;Note=Rv1457c%2C (MTV007.04c)%2C len: 261 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below)%2C equivalent to Z99125|MLCL536.32 from Mycobacterium leprae (265 aa)%2C FASTA scores: opt: 1415%2C E(): 0%2C (83.1%25 identity in 260 aa overlap).;gbkey=CDS;locus_tag=Rv1457c;product=Probable unidentified antibiotic-transport integral membrane ABC transporter;protein_id=CCP44216.1;transl_table=11
AL123456.3	EMBL	gene	1643319	1644260	.	-	.	ID=gene-Rv1458c;Name=Rv1458c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1458c
AL123456.3	EMBL	CDS	1643319	1644260	.	-	0	ID=cds-CCP44217.1;Parent=gene-Rv1458c;Dbxref=EnsemblGenomes-Gn:Rv1458c,EnsemblGenomes-Tr:CCP44217,GOA:O53149,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O53149,NCBI_GP:CCP44217.1;Name=CCP44217.1;Note=Rv1458c%2C (MTV007.05c)%2C len: 313 aa. Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below)%2C equivalent to Z99125|MLCL536.31 from Mycobacterium leprae (315 aa)%2C FASTA scores: opt: 1812%2C E(): 0%2C (88.0%25 identity in 308 aa overlap). Similar to AF027770|AF027770_7 ABC-type transporter in FxbA region in Mycobacterium smegmatis (284 aa)%2C FASTA scores: opt: 1412%2C E(): 0%2C (85.1%25 identity in 248 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1458c;product=Probable unidentified antibiotic-transport ATP-binding protein ABC transporter;protein_id=CCP44217.1;transl_table=11
AL123456.3	EMBL	repeat_region	1644261	1644313	.	-	.	ID=id-AL123456.3:1644261..1644313;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	1644314	1644364	.	-	.	ID=id-AL123456.3:1644314..1644364;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	1644363	1646138	.	-	.	ID=gene-Rv1459c;Name=Rv1459c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1459c
AL123456.3	EMBL	CDS	1644363	1646138	.	-	0	ID=cds-CCP44218.1;Parent=gene-Rv1459c;Dbxref=EnsemblGenomes-Gn:Rv1459c,EnsemblGenomes-Tr:CCP44218,GOA:O53150,NCBI_GP:CCP44218.1;Name=CCP44218.1;Note=Rv1459c%2C (MTV007.06c)%2C len: 591 aa. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Possible conserved integral membrane protein%2C equivalent to MLCL536.30|Z99125 hypothetical protein from Mycobacterium leprae (593 aa)%2C FASTA scores: opt: 1670%2C E(): 0%2C (78.6%25 identity in 585 aa overlap). Also similar to M. tuberculosis protein Rv2174|MTV021.07 (33.1%25 identity in 523 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1459c;product=Possible conserved integral membrane protein;protein_id=CCP44218.1;transl_table=11
AL123456.3	EMBL	gene	1646186	1646992	.	+	.	ID=gene-Rv1460;Name=Rv1460;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1460
AL123456.3	EMBL	CDS	1646186	1646992	.	+	0	ID=cds-CCP44219.1;Parent=gene-Rv1460;Dbxref=EnsemblGenomes-Gn:Rv1460,EnsemblGenomes-Tr:CCP44219,GOA:O53151,InterPro:IPR011991,UniProtKB/TrEMBL:O53151,NCBI_GP:CCP44219.1;Name=CCP44219.1;Note=Rv1460%2C (MTV007.07)%2C len: 268 aa. Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa)%2C FASTA scores: opt: 1273%2C E(): 0%2C (79.6%25 identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 - 89. Start changed since original submission.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1460;product=Probable transcriptional regulatory protein;protein_id=CCP44219.1;transl_table=11
AL123456.3	EMBL	gene	1646989	1649529	.	+	.	ID=gene-Rv1461;Name=Rv1461;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1461
AL123456.3	EMBL	CDS	1646989	1649529	.	+	0	ID=cds-CCP44220.1;Parent=gene-Rv1461;Dbxref=EnsemblGenomes-Gn:Rv1461,EnsemblGenomes-Tr:CCP44220,GOA:P9WFP7,InterPro:IPR000825,InterPro:IPR003586,InterPro:IPR003587,InterPro:IPR004042,InterPro:IPR006141,InterPro:IPR006142,InterPro:IPR007868,InterPro:IPR010231,InterPro:IPR027434,InterPro:IPR028992,NCBI_GP:CCP44220.1;Name=CCP44220.1;Note=Rv1461%2C (MTV007.08)%2C len: 846 aa. Conserved protein. Equivalent of spliced protein from Mycobacterium leprae MLCL536.28c len: 869. Residues 1-253 represent N-extein%2Cand 613-846 the C-extein. The intein present from residues 254 - 612 is different in sequence and site of the insertion from the one present in MLCL536.28c. FASTA scores: Z99125|MLCL536_23 Mycobacterium leprae cosmid L536 (869 aa)%2C opt: 1498 E(): 0%2C (54.1%25 identity in 917 aa overlap). The mature protein is similar to Z99120|BSUB0017_150 hypothetical Bacillus subtilis protein (465 aa)%2C FASTA scores: opt:1053%2C E(): 0%2C (34.8%25 identity in 821 aa overlap). The intein shows some similarity to inteins from U67548|MJU67548_6 Methanococcus jannaschii (895 aa)%2C FASTA scores: opt: 181%2C E(): 0.00023%2C (25.2%25 identity in 274 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1461;product=Conserved protein;protein_id=CCP44220.1;transl_table=11
AL123456.3	EMBL	gene	1649526	1650719	.	+	.	ID=gene-Rv1462;Name=Rv1462;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1462
AL123456.3	EMBL	CDS	1649526	1650719	.	+	0	ID=cds-CCP44221.1;Parent=gene-Rv1462;Dbxref=EnsemblGenomes-Gn:Rv1462,EnsemblGenomes-Tr:CCP44221,GOA:P9WFP5,InterPro:IPR000825,InterPro:IPR011542,NCBI_GP:CCP44221.1;Name=CCP44221.1;Note=Rv1462%2C (MTV007.09)%2C len: 397 aa. Conserved hypothetical protein. Equivalent to MLCL536.27c|Z99125 hypothetical protein from Mycobacterium leprae (392 aa)%2CFASTA scores: opt: 2059%2C E(): 0%2C (80.4%25 identity in 392 aa overlap). Also similar to nearby Mycobacterium tuberculosis hypothetical protein Rv1461.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1462;product=Conserved hypothetical protein;protein_id=CCP44221.1;transl_table=11
AL123456.3	EMBL	gene	1650716	1651516	.	+	.	ID=gene-Rv1463;Name=Rv1463;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1463
AL123456.3	EMBL	CDS	1650716	1651516	.	+	0	ID=cds-CCP44222.1;Parent=gene-Rv1463;Dbxref=EnsemblGenomes-Gn:Rv1463,EnsemblGenomes-Tr:CCP44222,GOA:O53154,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR010230,InterPro:IPR027417,UniProtKB/TrEMBL:O53154,NCBI_GP:CCP44222.1;Name=CCP44222.1;Note=Rv1463%2C (MTV007.10)%2C len: 266 aa. Probable conserved ATP-binding protein ABC transporter%2C equivalent to Z99125|MLCL536.26c putative ABC transporter ATP-binding protein from Mycobacterium leprae (260 aa)%2C FASTA scores: opt: 1444%2C E(): 0%2C (86.0%25 identity in 267 aa overlap). Very similar to U38804|PPU38804_55 ATP-dependent transporter YCF16 from porphyra purpurea chloroplast (251 aa)%2C FASTA scores: opt: 822%2C E(): 0%2C (52.4%25 identity in 248 aa overlap)%3B and similar to others. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1463;product=Probable conserved ATP-binding protein ABC transporter;protein_id=CCP44222.1;transl_table=11
AL123456.3	EMBL	gene	1651518	1652771	.	+	.	ID=gene-Rv1464;Name=csd;gbkey=Gene;gene=csd;gene_biotype=protein_coding;locus_tag=Rv1464
AL123456.3	EMBL	CDS	1651518	1652771	.	+	0	ID=cds-CCP44223.1;Parent=gene-Rv1464;Dbxref=EnsemblGenomes-Gn:Rv1464,EnsemblGenomes-Tr:CCP44223,GOA:P9WQ69,InterPro:IPR000192,InterPro:IPR010970,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR020578,NCBI_GP:CCP44223.1;Name=CCP44223.1;Note=Rv1464%2C (MTV007.11)%2C len: 417 aa. Probable csd%2Ccysteine desulfurase. Equivalent to Q49690|MLCL536.25C cysteine desulfurase from Mycobacterium leprae (418 aa)%2CFASTA scores: opt: 2333%2C E(): 0%2C (85.4%25 identity in 417 aa overlap)%3B and similar to cysteine desulfurase from other organisms. Also similar to M. tuberculosis proteins Rv3025c|ISCS and Rv3778c. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. Belongs to class-V of pyridoxal-phosphate-dependent aminotransferases. CSD subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=csd;inference=protein motif:PROSITE:PS00595;locus_tag=Rv1464;product=Probable cysteine desulfurase Csd;protein_id=CCP44223.1;transl_table=11
AL123456.3	EMBL	gene	1652768	1653256	.	+	.	ID=gene-Rv1465;Name=Rv1465;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1465
AL123456.3	EMBL	CDS	1652768	1653256	.	+	0	ID=cds-CCP44224.1;Parent=gene-Rv1465;Dbxref=EnsemblGenomes-Gn:Rv1465,EnsemblGenomes-Tr:CCP44224,GOA:O53156,InterPro:IPR002871,UniProtKB/TrEMBL:O53156,NCBI_GP:CCP44224.1;Name=CCP44224.1;Note=Rv1465%2C (MTV007.12)%2C len: 162 aa. Possible nitrogen fixation related protein. Equivalent to Z99125|MLCL536.24c nitrogen fixation protein NIFU from Mycobacterium leprae (165 aa)%2C FASTA scores: opt: 870%2C E(): 0%2C (81.8%25 identity in 165 aa overlap). Also similar to O32163|Z99120|NIFU_BACSU NifU-like protein from Bacillus subtilis (147 aa)%2C FASTA scores: opt: 354%2C E(): 4.1e-17%2C(38.3%25 identity in 141 aa overlap) and to AL096839|SCC22.02 hypothetical protein from Streptomyces coelicolor (156 aa)%2CFASTA scores: opt: 569%2C E(): 1.2e-31%2C (56.3%25 identity in 158 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1465;product=Possible nitrogen fixation related protein;protein_id=CCP44224.1;transl_table=11
AL123456.3	EMBL	gene	1653231	1653578	.	+	.	ID=gene-Rv1466;Name=Rv1466;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1466
AL123456.3	EMBL	CDS	1653231	1653578	.	+	0	ID=cds-CCP44225.1;Parent=gene-Rv1466;Dbxref=EnsemblGenomes-Gn:Rv1466,EnsemblGenomes-Tr:CCP44225,GOA:O53157,InterPro:IPR002744,UniProtKB/TrEMBL:O53157,NCBI_GP:CCP44225.1;Name=CCP44225.1;Note=Rv1466%2C (MTV007.13)%2C len: 115 aa. Conserved protein. Equivalent to Z99125|MLCL536.23c hypothetical protein from Mycobacterium leprae (115 aa)%2C FASTA scores: opt: 648%2C E(): 0%2C (81.7%25 identity in 115 aa overlap). Similar to ORF's downstream of sigma factors in Streptococcus mutans and Streptococcus pneumoniae e.g. O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa). Alternative TTG start possible at 13757 then avoids overlap with MTV007.12.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1466;product=Conserved protein;protein_id=CCP44225.1;transl_table=11
AL123456.3	EMBL	gene	1653673	1655502	.	-	.	ID=gene-Rv1467c;Name=fadE15;gbkey=Gene;gene=fadE15;gene_biotype=protein_coding;locus_tag=Rv1467c
AL123456.3	EMBL	CDS	1653673	1655502	.	-	0	ID=cds-CCP44226.1;Parent=gene-Rv1467c;Dbxref=EnsemblGenomes-Gn:Rv1467c,EnsemblGenomes-Tr:CCP44226,GOA:O53158,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,InterPro:IPR020953,InterPro:IPR025878,UniProtKB/TrEMBL:O53158,NCBI_GP:CCP44226.1;Name=CCP44226.1;Note=Rv1467c%2C (MTV007.14c)%2C len: 609 aa. Probable fadE15%2Cacyl-CoA dehydrogenase%2C highly similar to NP_302639.1|NC_002677 acyl-CoA dehydrogenase from Mycobacterium leprae (611 aa). Also highly similar to many e.g. T36481 probable acyl-CoA dehydrogenase (fragment) from Streptomyces coelicolor (491 aa) (has its N-terminus very shorter)%3B NP_384640.1|NC_003047 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (598 aa)%3B ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain specific) from Megasphaera elsdenii (383 aa)%2C FASTA scores: E(): 2e-12%2C (25.4%25 identity in 410 aa overlap)%3B etc. Also highly similar to fadE5|Rv0244c|MTV034.10c acyl-CoA dehydrogenase from Mycobacterium tuberculosis (611 aa)%3B and similar to other proteins from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE15;locus_tag=Rv1467c;product=Probable acyl-CoA dehydrogenase FadE15;protein_id=CCP44226.1;transl_table=11
AL123456.3	EMBL	gene	1655609	1656721	.	-	.	ID=gene-Rv1468c;Name=PE_PGRS29;gbkey=Gene;gene=PE_PGRS29;gene_biotype=protein_coding;locus_tag=Rv1468c
AL123456.3	EMBL	CDS	1655609	1656721	.	-	0	ID=cds-CCP44227.1;Parent=gene-Rv1468c;Dbxref=EnsemblGenomes-Gn:Rv1468c,EnsemblGenomes-Tr:CCP44227,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FP0,NCBI_GP:CCP44227.1;Name=CCP44227.1;Note=Rv1468c%2C (MTV007.15c)%2C len: 370 aa. PE_PGRS29%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS29;locus_tag=Rv1468c;product=PE-PGRS family protein PE_PGRS29;protein_id=CCP44227.1;transl_table=11
AL123456.3	EMBL	gene	1656963	1658936	.	+	.	ID=gene-Rv1469;Name=ctpD;gbkey=Gene;gene=ctpD;gene_biotype=protein_coding;locus_tag=Rv1469
AL123456.3	EMBL	CDS	1656963	1658936	.	+	0	ID=cds-CCP44228.1;Parent=gene-Rv1469;Dbxref=EnsemblGenomes-Gn:Rv1469,EnsemblGenomes-Tr:CCP44228,GOA:P9WPT3,InterPro:IPR001757,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,InterPro:IPR027256,NCBI_GP:CCP44228.1;Name=CCP44228.1;Note=Rv1469%2C (MTV007.16)%2C len: 657 aa. Probable ctpD%2Ccation-transporting P-type ATPase D (transmembrane protein)%2C highly similar to others e.g. T35947 probable cation-transporting ATPase from Streptomyces coelicolor (638 aa)%3B NP_442633.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (642 aa)%2C FASTA scores: opt: 1438%2C E(): 0%2C (41.9%25 identity in 592 aa overlap)%3B NP_389268.1|NC_000964 protein similar to heavy metal-transporting ATPase from Bacillus subtilis (637 aa)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Rv3743c|MTV025.091c|CTPJ (660 aa). Contains PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases)%2C subfamily IB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpD;inference=protein motif:PROSITE:PS00154;locus_tag=Rv1469;product=Probable cation transporter P-type ATPase D CtpD;protein_id=CCP44228.1;transl_table=11
AL123456.3	EMBL	gene	1658980	1659354	.	+	.	ID=gene-Rv1470;Name=trxA;gbkey=Gene;gene=trxA;gene_biotype=protein_coding;locus_tag=Rv1470
AL123456.3	EMBL	CDS	1658980	1659354	.	+	0	ID=cds-CCP44229.1;Parent=gene-Rv1470;Dbxref=EnsemblGenomes-Gn:Rv1470,EnsemblGenomes-Tr:CCP44229,GOA:O53161,InterPro:IPR005746,InterPro:IPR012336,InterPro:IPR013766,UniProtKB/TrEMBL:O53161,NCBI_GP:CCP44229.1;Name=CCP44229.1;Note=Rv1470%2C (MTV007.17)%2C len: 124 aa. Probable trxA%2Cthioredoxin%2C similar to many e.g. P12243|THI1_SYNP7 thioredoxin 1 from Synechococcus sp. (106 aa)%2C FASTA scores: opt: 201%2C E(): 9.2e-08%2C (35.4%25 identity in 99 aa overlap)%3B etc. Highly similar to downstream ORF Rv1471|trxB1 probable thioredoxin from Mycobacterium tuberculosis (123 aa)%2C FASTA scores: opt: 402%2C E(): 0%2C(54.4%25 identity in 114 aa overlap). Warning: note that Rv3914|MT4033|MTV028.05|trxC can be alternatively named trxA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trxA;locus_tag=Rv1470;product=Probable thioredoxin TrxA;protein_id=CCP44229.1;transl_table=11
AL123456.3	EMBL	gene	1659370	1659741	.	+	.	ID=gene-Rv1471;Name=trxB1;gbkey=Gene;gene=trxB1;gene_biotype=protein_coding;gene_synonym=trxB;locus_tag=Rv1471
AL123456.3	EMBL	CDS	1659370	1659741	.	+	0	ID=cds-CCP44230.1;Parent=gene-Rv1471;Dbxref=EnsemblGenomes-Gn:Rv1471,EnsemblGenomes-Tr:CCP44230,GOA:L7N664,InterPro:IPR005746,InterPro:IPR012336,InterPro:IPR013766,InterPro:IPR017937,UniProtKB/TrEMBL:L7N664,NCBI_GP:CCP44230.1;Name=CCP44230.1;Note=Rv1471%2C (MTV007.18)%2C len: 123 aa. Probable trxB1%2Cthioredoxin%2C similar to many bacterial thioredoxins e.g. P33636|THI2_ECOLI from Escherichia coli (139 aa)%2C FASTA scores: opt: 290%2C E(): 1.8e-13%2C (44.3%25 identity in 97 aa overlap)%3B etc. Highly similar to Rv1470|TrxA probable thioredoxin from Mycobacterium tuberculosis (124 aa)%2C FASTA scores: opt: 402%2C E(): 1.2e-32%2C (54.4%25 identity in 114 aa overlap). Contains PS00194 Thioredoxin family active site. Belongs to the thioredoxin family. Note that previously known as trxB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trxB1;inference=protein motif:PROSITE:PS00194;locus_tag=Rv1471;product=Probable thioredoxin TrxB1;protein_id=CCP44230.1;transl_table=11
AL123456.3	EMBL	gene	1659763	1660620	.	+	.	ID=gene-Rv1472;Name=echA12;gbkey=Gene;gene=echA12;gene_biotype=protein_coding;locus_tag=Rv1472
AL123456.3	EMBL	CDS	1659763	1660620	.	+	0	ID=cds-CCP44231.1;Parent=gene-Rv1472;Dbxref=EnsemblGenomes-Gn:Rv1472,EnsemblGenomes-Tr:CCP44231,GOA:P9WNN7,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,NCBI_GP:CCP44231.1;Name=CCP44231.1;Note=Rv1472%2C (MTV007.19)%2C len: 285 aa. Possible echA12%2Cenoyl-CoA hydratase%2C highly similar to P53526|ECHH_MYCLE|NP_301896.1|NC_002677 possible enoyl-CoA hydratase/isomerase from Mycobacterium leprae (294 aa)%2CFASTA scores: opt: 1265%2C E(): 0%2C (72.0%25 identity in 271 aa overlap). Also similar to others e.g. CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia coli strain K12 (262 aa)%3B CAC44593.1|AL596162 putative enoyl-CoA hydratase from Streptomyces coelicolor (275 aa)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. ECHA16|Rv2831|MTCY16B7.11c (249 aa)%2C FASTA scores: opt: 232%2C E(): 1.3e-15%2C (33.8%25 identity in 204 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA12;inference=protein motif:PROSITE:PS00166;locus_tag=Rv1472;product=Possible enoyl-CoA hydratase EchA12 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP44231.1;transl_table=11
AL123456.3	EMBL	gene	1660656	1662284	.	+	.	ID=gene-Rv1473;Name=Rv1473;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1473
AL123456.3	EMBL	CDS	1660656	1662284	.	+	0	ID=cds-CCP44232.1;Parent=gene-Rv1473;Dbxref=EnsemblGenomes-Gn:Rv1473,EnsemblGenomes-Tr:CCP44232,GOA:O53164,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O53164,NCBI_GP:CCP44232.1;Name=CCP44232.1;Note=Rv1473%2C (MTV007.20)%2C len: 542 aa. Possible macrolide-transport ATP-binding protein ABC transporter (see citation below)%2C possibly in EF-3 subfamily. Similar to many ABC-transporters e.g. D90909_48|YHES_HAEIN from Synechocystis sp. strain PCC6803 (574 aa)%2C FASTA scores: opt: 870%2C E(): 0%2C (33.3%25 identity in 525 aa overlap)%3B P44808|YHES_HAEIN from Haemophilus influenzae (638 aa)%2CFASTA scores: opt: 706%2C E(): 0%2C (33.7%25 identity in 517 aa overlap)%3B etc. Contains two PS00017 ATP/GTP-binding site motif A (P-loop)%2C and two PS00211 ABC transporter family signatures. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1473;product=Probable macrolide-transport ATP-binding protein ABC transporter;protein_id=CCP44232.1;transl_table=11
AL123456.3	EMBL	gene	1662381	1662572	.	+	.	ID=gene-Rv1473A;Name=Rv1473A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1473A
AL123456.3	EMBL	CDS	1662381	1662572	.	+	0	ID=cds-CCP44233.1;Parent=gene-Rv1473A;Dbxref=EnsemblGenomes-Gn:Rv1473A,EnsemblGenomes-Tr:CCP44233,UniProtKB/TrEMBL:L7N691,NCBI_GP:CCP44233.1;Name=CCP44233.1;Note=Rv1473A%2C len: 63 aa. Possible transcriptional regulator%2C CDS predicted by GC plot. Similar to SCI8.24c|AL132644_24 putative transcriptional regulator from Streptomyces coelicolor (73 aa)%2C FASTA scores: opt: 210%2C E(): 1.5e-08%2C (56.15%25 identity in 57 aa overlap).;gbkey=CDS;locus_tag=Rv1473A;product=Possible transcriptional regulatory protein;protein_id=CCP44233.1;transl_table=11
AL123456.3	EMBL	gene	1662641	1663204	.	-	.	ID=gene-Rv1474c;Name=Rv1474c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1474c
AL123456.3	EMBL	CDS	1662641	1663204	.	-	0	ID=cds-CCP44234.1;Parent=gene-Rv1474c;Dbxref=EnsemblGenomes-Gn:Rv1474c,EnsemblGenomes-Tr:CCP44234,GOA:O53165,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O53165,NCBI_GP:CCP44234.1;Name=CCP44234.1;Note=Rv1474c%2C (MTV007.21c)%2C len: 187 aa. Probable transcription regulator%2C equivalent to AF0021|AF002133_1 transcriptional regulator from Mycobacterium avium strain GIR10 (82 aa)%2C FASTA scores: opt: 490%2C E(): 6.7e-26%2C (92.5%25 identity in 80 aa overlap). Also similar to Q59431|UIDR_ECOLI UID operon repressor (GUS operon) from Escherichia coli (196 aa)%2C FASTA scores: opt: 192%2C E(): 5.8e-06%2C (28.5%25 identity in 172 aa overlap). Belongs to the TetR/AcrR family of transcriptional regulators. Helix turn helix motif predicted at aa 33-54 (+3.40 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1474c;product=Probable transcriptional regulatory protein;protein_id=CCP44234.1;transl_table=11
AL123456.3	EMBL	gene	1663215	1666046	.	-	.	ID=gene-Rv1475c;Name=acn;gbkey=Gene;gene=acn;gene_biotype=protein_coding;locus_tag=Rv1475c
AL123456.3	EMBL	CDS	1663215	1666046	.	-	0	ID=cds-CCP44235.1;Parent=gene-Rv1475c;Dbxref=EnsemblGenomes-Gn:Rv1475c,EnsemblGenomes-Tr:CCP44235,GOA:O53166,InterPro:IPR000573,InterPro:IPR001030,InterPro:IPR015928,InterPro:IPR015931,InterPro:IPR015932,InterPro:IPR015934,InterPro:IPR015937,InterPro:IPR018136,UniProtKB/TrEMBL:O53166,NCBI_GP:CCP44235.1;Name=CCP44235.1;Note=Rv1475c%2C (MTV007.22c)%2C len: 943 aa. Probable acn%2Ciron-regulated aconitate hydratase%2C similar to many e.g. P70920|ACON_BRAJA aconitate hydratase from Bradyrhizobium japonicum (906 aa)%2C FASTA scores: opt:1912%2C E(): 0%2C (54.8%25 identity in 958 aa overlap)%3B closest to AF0021|AF002133_2 Mycobacterium avium strain GIR10 (961 aa)%2C FASTA scores: opt: 5072%2C E(): 0%2C (82.8%25 identity in 943 aa overlap). Note aconitase has an active (4FE-4S) and an inactive (3FE-4S) forms. The active (4FE-4S) cluster is part of the catalytic site that interconverts citrate%2C cis-aconitase%2C and isocitrate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=acn;locus_tag=Rv1475c;product=Probable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase);protein_id=CCP44235.1;transl_table=11
AL123456.3	EMBL	gene	1666204	1666764	.	+	.	ID=gene-Rv1476;Name=Rv1476;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1476
AL123456.3	EMBL	CDS	1666204	1666764	.	+	0	ID=cds-CCP44236.1;Parent=gene-Rv1476;Dbxref=EnsemblGenomes-Gn:Rv1476,EnsemblGenomes-Tr:CCP44236,GOA:O53167,UniProtKB/TrEMBL:O53167,NCBI_GP:CCP44236.1;Name=CCP44236.1;Note=Rv1476%2C (MTV007.23)%2C len: 186 aa. Possibly membrane protein%2C TMhelix 138-60. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1476;product=Possible membrane protein;protein_id=CCP44236.1;transl_table=11
AL123456.3	EMBL	gene	1666990	1668408	.	+	.	ID=gene-Rv1477;Name=ripA;gbkey=Gene;gene=ripA;gene_biotype=protein_coding;locus_tag=Rv1477
AL123456.3	EMBL	CDS	1666990	1668408	.	+	0	ID=cds-CCP44237.1;Parent=gene-Rv1477;Dbxref=EnsemblGenomes-Gn:Rv1477,EnsemblGenomes-Tr:CCP44237,GOA:O53168,InterPro:IPR000064,PDB:2XIV,PDB:3NE0,PDB:3PBC,PDB:3S0Q,PDB:4Q4G,PDB:4Q4N,PDB:4Q4T,NCBI_GP:CCP44237.1;Name=CCP44237.1;Note=Rv1477%2C (MTV007.24)%2C len: 472 aa. RipA%2Cpeptidoglycan hydrolase (see Hett et al.%2C 2007). Secreted%2Ccell-associated protein. The last 277 residues are nearly identical to those of AF0060|AF006054_1 hypothetical invasion protein INV1 from Mycobacterium tuberculosis (277 aa)%2C FASTA scores: opt: 1833%2C E(): 0%2C (98.2%25 identity in 277 aa overlap)%3B also very similar to AF0021|AF002133_4 invasin 1 protein from Mycobacterium avium (273 aa)%2C FASTA scores: opt: 1452%2C E(): 0%2C (78.1%25 identity in 279 aa overlap). Similar to Rv1566c|MTCY336.37|Z95586 Mycobacterium tuberculosis cosmid (230 aa)%2C FASTA scores: opt: 528%2C E(): 4.4e-20%2C (52.0%25 identity in 150 aa overlap)%3B and weakly similar to p60 proteins of Listeria spp throughout its length e.g. M80351|LISIAPB_1 Listeria monocytogenes iap-related protein (478 aa)%2C FASTA scores: opt: 251%2C E(): 8e-06%2C (24.4%25 identity in 487 aa overlap). C-terminal domain highly similar to next orf Rv1478|MTV007.25. Interacts with RpfB and RpfE (see Hett et al.%2C 2007). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ripA;locus_tag=Rv1477;product=Peptidoglycan hydrolase;protein_id=CCP44237.1;transl_table=11
AL123456.3	EMBL	gene	1668419	1669144	.	+	.	ID=gene-Rv1478;Name=Rv1478;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1478
AL123456.3	EMBL	CDS	1668419	1669144	.	+	0	ID=cds-CCP44238.1;Parent=gene-Rv1478;Dbxref=EnsemblGenomes-Gn:Rv1478,EnsemblGenomes-Tr:CCP44238,GOA:P9WHU5,InterPro:IPR000064,PDB:3PBI,NCBI_GP:CCP44238.1;Name=CCP44238.1;Note=Rv1478%2C (MTV007.25)%2C len: 241 aa. Possible invasion protein. Possibly exported protein%2C nearly identical to AF0060|AF006054_2 hypothetical invasion protein INV2 of Mycobacterium tuberculosis (240 aa)%2C FASTA scores: opt: 1509%2C E(): 0%2C (95.0%25 identity in 241 aa overlap)%3B very similar to AF0021|AF002133_5 hypothetical invasion protein INV2 from Mycobacterium avium (244 aa)%2C FASTA scores: opt: 1269%2C E():0%2C (78.0%25 identity in 246 aa overlap). Also similar to Mycobacterium tuberculosis protein MTCY336.37 and weakly similar to C-terminal segment of p60 proteins of Listeria spp.e.g. Q01836|P60_LISIN protein P60 precursor (481 aa)%2C FASTA scores: opt: 241%2C E():4e-07%2C (37.7%25 identity in 122 aa overlap). Highly similar to C-terminal domain of preceeding ORF Rv1477|MTV007.24 (472 aa)%2C FASTA scores: opt: 864%2C E(): 0%2C (60.1%25 identity in 213 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1478;product=Possible invasion protein;protein_id=CCP44238.1;transl_table=11
AL123456.3	EMBL	gene	1669283	1670416	.	+	.	ID=gene-Rv1479;Name=moxR1;gbkey=Gene;gene=moxR1;gene_biotype=protein_coding;gene_synonym=moxR;locus_tag=Rv1479
AL123456.3	EMBL	CDS	1669283	1670416	.	+	0	ID=cds-CCP44239.1;Parent=gene-Rv1479;Dbxref=EnsemblGenomes-Gn:Rv1479,EnsemblGenomes-Tr:CCP44239,GOA:Q79FN7,InterPro:IPR003593,InterPro:IPR011703,InterPro:IPR016366,InterPro:IPR027417,UniProtKB/TrEMBL:Q79FN7,NCBI_GP:CCP44239.1;Name=CCP44239.1;Note=Rv1479%2C (MTV007.26)%2C len: 377 aa. Probable moxR1%2Ctranscriptional regulatory protein%2C similar to X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi (329 aa)%2C FASTA scores: opt: 850%2C E():0%2C (43.5%25 identity in 317 aa overlap)%3B and P. denitrificans. Highly similar to MoxR homologs of Mycobacterium tuberculosis and Mycobacterium avium (but these both differ at C-terminus) e.g. Rv3692%2C Rv3164c%2C and AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309 aa)%2C FASTA scores: opt: 1181%2C E(): 0%2C (83.7%25 identity in 227 aa overlap). Also similar to O33173|AF006054 MoxR fragment from Mycobacterium tuberculosis (211 aa)%2C FASTA scores: opt: 1305%2C E(): 0%2C(94.3%25 identity in 212 aa overlap). Note that previously known as moxR.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moxR1;locus_tag=Rv1479;product=Probable transcriptional regulatory protein MoxR1;protein_id=CCP44239.1;transl_table=11
AL123456.3	EMBL	gene	1670413	1671366	.	+	.	ID=gene-Rv1480;Name=Rv1480;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1480
AL123456.3	EMBL	CDS	1670413	1671366	.	+	0	ID=cds-CCP44240.1;Parent=gene-Rv1480;Dbxref=EnsemblGenomes-Gn:Rv1480,EnsemblGenomes-Tr:CCP44240,GOA:P9WLX5,InterPro:IPR002035,InterPro:IPR002881,NCBI_GP:CCP44240.1;Name=CCP44240.1;Note=Rv1480%2C (MTV007.27%2CMTCY227.01)%2C len: 317 aa. Conserved protein%2C last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium protein MAV169 (169 aa)%2C FASTA scores: opt: 642%2C E(): 0%2C (84.2%25 identity in 114 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv3163c and Rv3693.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1480;product=Conserved protein;protein_id=CCP44240.1;transl_table=11
AL123456.3	EMBL	gene	1671377	1672384	.	+	.	ID=gene-Rv1481;Name=Rv1481;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1481
AL123456.3	EMBL	CDS	1671377	1672384	.	+	0	ID=cds-CCP44241.1;Parent=gene-Rv1481;Dbxref=EnsemblGenomes-Gn:Rv1481,EnsemblGenomes-Tr:CCP44241,GOA:P9WFJ7,InterPro:IPR002035,InterPro:IPR022933,InterPro:IPR024163,NCBI_GP:CCP44241.1;Name=CCP44241.1;Note=Rv1481%2C (MTCY277.02)%2C len: 335 aa. Probable membrane protein%2C highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa)%2CFASTA scores: opt: 1904%2C E(): 0%2C (89.0%25 identity in 337 aa overlap). Similar to AF116251|AF116251_1 BatA protein from Bacteroides fragilis (327 aa)%2C FASTA scores: opt: 317%2C E(): 2e-12%2C (26.5%25 identity in 340 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1481;product=Probable membrane protein;protein_id=CCP44241.1;transl_table=11
AL123456.3	EMBL	gene	1672457	1673299	.	-	.	ID=gene-Rv1482c;Name=Rv1482c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1482c
AL123456.3	EMBL	CDS	1672457	1673299	.	-	0	ID=cds-CCP44242.1;Parent=gene-Rv1482c;Dbxref=EnsemblGenomes-Gn:Rv1482c,EnsemblGenomes-Tr:CCP44242,InterPro:IPR025159,UniProtKB/TrEMBL:P71763,NCBI_GP:CCP44242.1;Name=CCP44242.1;Note=Rv1482c%2C (MTCY277.03c)%2C len: 280 aa. Conserved hypothetical protein%2C highly similar to O07396|AF002133 Mycobacterium avium protein MAV346 (346 aa)%2C FASTA scores: E(): 0%2C (65.2%25 identity in 342 aa overlap)%3B slight similarity to GRPE_ECOLI|P09372 heat shock protein from E. coli (197 aa)%2C FASTA scores: opt: 139%2C E(): 0.012%2C (28.3%25 identity in 159 aa overlap). Similar to Mycobacterium tuberculosis hypothetical proteins Rv3517%2C Rv3555c%2CRv3714c%2C Rv1073%2C etc. Start changed since first submission (-59 aa).;gbkey=CDS;locus_tag=Rv1482c;product=Conserved hypothetical protein;protein_id=CCP44242.1;transl_table=11
AL123456.3	EMBL	gene	1673440	1674183	.	+	.	ID=gene-Rv1483;Name=fabG1;gbkey=Gene;gene=fabG1;gene_biotype=protein_coding;gene_synonym=mabA;locus_tag=Rv1483
AL123456.3	EMBL	CDS	1673440	1674183	.	+	0	ID=cds-CCP44243.1;Parent=gene-Rv1483;Dbxref=EnsemblGenomes-Gn:Rv1483,EnsemblGenomes-Tr:CCP44243,GOA:P9WGT3,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,PDB:1UZL,PDB:1UZM,PDB:1UZN,PDB:2NTN,NCBI_GP:CCP44243.1;Name=CCP44243.1;Note=Rv1483%2C (MTCY277.04)%2C len: 247 aa. FabG1 (alternate gene name: mabA)%2C 3-oxoacyl-[acyl-carrier protein] reductase (see citations below)%2C equivalent to O07399|FABG_MYCAV 3-oxoacyl-[acyl-carrier protein] reductase from Mycobacterium avium (255 aa)%3B P71534|FABG_MYCSM 3-oxoacyl-[acyl-carrier protein] reductase from Mycobacterium smegmatis (255 aa)%3B and NP_302228.1|NC_002677 3-oxoacyl-[ACP] reductase (aka MabA) from Mycobacterium leprae (253 aa). Also highly similar to many e.g. T36779 probable 3-oxacyl-(acyl-carrier-protein) reductase from Streptomyces coelicolor (234 aa)%3B FABG_ECOLI|P25716|NP_415611.1|NC_000913 3-oxoacyl-[acyl-carrier-protein] reductase from Escherichia coli strain K12 (244 aa)%2C FASTA scores: opt: 664%2C E(): 6.8e-35%2C (44.4%25 identity in 241 aa overlap)%3B etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fabG1;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1483;product=3-oxoacyl-[acyl-carrier protein] reductase FabG1 (3-ketoacyl-acyl carrier protein reductase) (mycolic acid biosynthesis a protein);protein_id=CCP44243.1;transl_table=11
AL123456.3	EMBL	gene	1674202	1675011	.	+	.	ID=gene-Rv1484;Name=inhA;gbkey=Gene;gene=inhA;gene_biotype=protein_coding;locus_tag=Rv1484
AL123456.3	EMBL	CDS	1674202	1675011	.	+	0	ID=cds-CCP44244.1;Parent=gene-Rv1484;Dbxref=EnsemblGenomes-Gn:Rv1484,EnsemblGenomes-Tr:CCP44244,GOA:P9WGR1,InterPro:IPR014358,InterPro:IPR016040,PDB:1BVR,PDB:1ENY,PDB:1ENZ,PDB:1P44,PDB:1P45,PDB:1ZID,PDB:2AQ8,PDB:2AQH,PDB:2AQI,PDB:2AQK,PDB:2B35,PDB:2B36,PDB:2B37,PDB:2H9I,PDB:2IDZ,PDB:2IE0,PDB:2IEB,PDB:2IED,PDB:2NSD,PDB:2NTJ,PDB:2NV6,PDB:2PR2,PDB:2X22,PDB:2X23,PDB:3FNE,PDB:3FNF,PDB:3FNG,PDB:3FNH,PDB:3OEW,PDB:3OEY,PDB:3OF2,PDB:4BGE,PDB:4BGI,PDB:4BII,PDB:4BQP,PDB:4BQR,PDB:4DQU,PDB:4DRE,PDB:4DTI,PDB:4OHU,PDB:4OXK,PDB:4OXN,PDB:4OXY,PDB:4OYR,PDB:4TRJ,PDB:4TZK,PDB:4TZT,PDB:4U0J,PDB:4U0K,NCBI_GP:CCP44244.1;Name=CCP44244.1;Note=Rv1484%2C (MTCY277.05)%2C len: 269 aa. InhA%2CNADH-dependent enoyl-[acyl-carrier-protein] reductase (see citations below). Identical to INHA_MYCTU|P46533 enoyl-[acyl-carrier-protein] reductase from Mycobacterium tuberculosis and G1155270 Mycobacterium bovis enoyl acp reductase. Some similarity to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=inhA;locus_tag=Rv1484;product=NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase);protein_id=CCP44244.1;transl_table=11
AL123456.3	EMBL	gene	1675017	1676051	.	+	.	ID=gene-Rv1485;Name=hemZ;gbkey=Gene;gene=hemZ;gene_biotype=protein_coding;locus_tag=Rv1485
AL123456.3	EMBL	CDS	1675017	1676051	.	+	0	ID=cds-CCP44245.1;Parent=gene-Rv1485;Dbxref=EnsemblGenomes-Gn:Rv1485,EnsemblGenomes-Tr:CCP44245,GOA:P9WNE3,InterPro:IPR001015,InterPro:IPR019772,NCBI_GP:CCP44245.1;Name=CCP44245.1;Note=Rv1485%2C (MTCY277.06)%2C len: 344 aa. HemZ%2Cferrochelatase (see citation below)%2C similar to many e.g. HEMZ_BACSU|P32396 ferrochelatase from Bacillus subtilus (310 aa)%2C FASTA scores: opt:490%2C E(): 2e-24%2C (30.2%25 identity in 295 aa overlap)%3B etc. Belongs to the ferrochelatase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemZ;locus_tag=Rv1485;product=Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase);protein_id=CCP44245.1;transl_table=11
AL123456.3	EMBL	gene	1676017	1676883	.	-	.	ID=gene-Rv1486c;Name=Rv1486c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1486c
AL123456.3	EMBL	CDS	1676017	1676883	.	-	0	ID=cds-CCP44246.1;Parent=gene-Rv1486c;Dbxref=EnsemblGenomes-Gn:Rv1486c,EnsemblGenomes-Tr:CCP44246,NCBI_GP:CCP44246.1;Name=CCP44246.1;Note=Rv1486c%2C (MTCY277.07c)%2C len: 288 aa. Conserved hypothetical protein%2C highly similar to YS07_MYCAV|O07402 hypothetical 33.5 kDa protein mav321 from Mycobacterium avium (320 aa)%2C FASTA scores: opt: 1217%2C E(): 0%2C (71.1%25 identity in 315 aa overlap). Weak similarity to AL079332|SCI5.07 hypothetical protein from Streptomyces coelicolor (259 aa)%2C FASTA scores: opt: 131%2C E(): 0.29%2C(32.3%25 identity in 279 aa overlap). Start changed since original submission.;gbkey=CDS;locus_tag=Rv1486c;product=Conserved hypothetical protein;protein_id=CCP44246.1;transl_table=11
AL123456.3	EMBL	gene	1676941	1677375	.	+	.	ID=gene-Rv1487;Name=Rv1487;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1487
AL123456.3	EMBL	CDS	1676941	1677375	.	+	0	ID=cds-CCP44247.1;Parent=gene-Rv1487;Dbxref=EnsemblGenomes-Gn:Rv1487,EnsemblGenomes-Tr:CCP44247,InterPro:IPR002810,InterPro:IPR012340,UniProtKB/TrEMBL:P71767,NCBI_GP:CCP44247.1;Name=CCP44247.1;Note=Rv1487%2C (MTCY277.08)%2C len: 144 aa. Conserved membrane protein. Highly similar to O07404|AF002133 MAV145 from Mycobacterium avium (145 aa)%2C FASTA scores: opt: 667%2CE(): 0%2C (72.5%25 identity in 142 aa overlap). Also similar to AL079332|SCI5.05 hypothetical protein from Streptomyces coelicolor (143 aa)%2C FASTA scores: opt: 344%2C E(): 1.3e-15%2C(44.8%25 identity in 134 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1487;product=Conserved membrane protein;protein_id=CCP44247.1;transl_table=11
AL123456.3	EMBL	gene	1677397	1678542	.	+	.	ID=gene-Rv1488;Name=Rv1488;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1488
AL123456.3	EMBL	CDS	1677397	1678542	.	+	0	ID=cds-CCP44248.1;Parent=gene-Rv1488;Dbxref=EnsemblGenomes-Gn:Rv1488,EnsemblGenomes-Tr:CCP44248,GOA:P9WPR9,InterPro:IPR001107,InterPro:IPR001972,InterPro:IPR018080,NCBI_GP:CCP44248.1;Name=CCP44248.1;Note=Rv1488%2C (MTCY277.09)%2C len: 381 aa. Possible exported conserved protein%3B contains possible N-terminal signal sequence. Similar to YBBK_ECOLI|P77367 hypothetical protein ybbK from Escherichia coli (305 aa)%2C FASTA scores: opt: 716%2C E(): 0%2C (37.1%25 identity in 307 aa overlap). Similar to stomatin-like proteins e.g. AF065260|AF065260_1 Clostridium difficile (320 aa)%2C FASTA scores: opt: 767%2C E(): 0%2C (42.3%25 identity in 307 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1488;product=Possible exported conserved protein;protein_id=CCP44248.1;transl_table=11
AL123456.3	EMBL	gene	1678552	1678908	.	+	.	ID=gene-Rv1489;Name=Rv1489;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1489
AL123456.3	EMBL	CDS	1678552	1678908	.	+	0	ID=cds-CCP44249.1;Parent=gene-Rv1489;Dbxref=EnsemblGenomes-Gn:Rv1489,EnsemblGenomes-Tr:CCP44249,UniProtKB/TrEMBL:L7N692,NCBI_GP:CCP44249.1;Name=CCP44249.1;Note=Rv1489%2C len: 118 aa. Conserved protein%2C similar to hypothetical proteins from Mycobacterium avium subsp. paratuberculosis and Streptomyces coelicolor e.g. AJ250017_1 insertion sequence IS900%2C Locus 3%2C putative invasion protein from M. paratuberculosis (138 aa)%2C FASTA scores: opt: 120%2C E(): 0.26%2C (34.375%25 identity in 96 aa overlap)%3B SCD6.11c|AL353815_11 possible integral membrane protein from Streptomyces coelicolor (136 aa)%2C FASTA scores: opt: 106%2C E(): 2.2%2C (35.9%25 identity in 103 aa overlap). ORF predicted by GC plot. Replaces previous Rv1489c on other strand.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1489;product=Conserved protein;protein_id=CCP44249.1;transl_table=11
AL123456.3	EMBL	gene	1678942	1679172	.	+	.	ID=gene-Rv1489A;Name=Rv1489A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1489A
AL123456.3	EMBL	CDS	1678942	1679172	.	+	0	ID=cds-CCP44250.1;Parent=gene-Rv1489A;Dbxref=EnsemblGenomes-Gn:Rv1489A,EnsemblGenomes-Tr:CCP44250,GOA:L7N6A8,InterPro:IPR006099,UniProtKB/TrEMBL:L7N6A8,NCBI_GP:CCP44250.1;Name=CCP44250.1;Note=Rv1489A%2C len: 76 aa. Conserved protein%2C similar to part of alpha subunit of many methylmalonyl-CoA mutases (~~750 aa). Size difference suggests possible gene fragment although Mycobacterium tuberculosis has intact methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU probable methylmalonyl-CoA mutase from Mycobacterium tuberculosis (750 aa)%2C FASTA scores: opt: 258%2C E(): 3.2e-10%2C (73.35%25 identity in 60 aa overlap). ORF predicted by GC plot.;gbkey=CDS;locus_tag=Rv1489A;product=Conserved protein;protein_id=CCP44250.1;transl_table=11
AL123456.3	EMBL	gene	1679322	1680629	.	+	.	ID=gene-Rv1490;Name=Rv1490;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1490
AL123456.3	EMBL	CDS	1679322	1680629	.	+	0	ID=cds-CCP44251.1;Parent=gene-Rv1490;Dbxref=EnsemblGenomes-Gn:Rv1490,EnsemblGenomes-Tr:CCP44251,GOA:P9WLX1,NCBI_GP:CCP44251.1;Name=CCP44251.1;Note=Rv1490%2C (MTCY277.12)%2C len: 435 aa. Probable membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1490;product=Probable membrane protein;protein_id=CCP44251.1;transl_table=11
AL123456.3	EMBL	gene	1681208	1681966	.	-	.	ID=gene-Rv1491c;Name=Rv1491c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1491c
AL123456.3	EMBL	CDS	1681208	1681966	.	-	0	ID=cds-CCP44252.1;Parent=gene-Rv1491c;Dbxref=EnsemblGenomes-Gn:Rv1491c,EnsemblGenomes-Tr:CCP44252,GOA:P9WFS3,InterPro:IPR015414,NCBI_GP:CCP44252.1;Name=CCP44252.1;Note=Rv1491c%2C (MTCY277.13c)%2C len: 252 aa. Conserved membrane protein. Similar to hypothetical proteins from many organisms e.g. YDJZ_ECOLI|P76221 Escherichia coli (235 aa)%2C FASTA scores: opt: 223%2C E():6.7 e-07%2C (31.7%25 identity in 145 aa overlap)%3B AL133252|SCE46.15 Streptomyces coelicolor (249 aa)%2C FASTA scores: opt: 378%2C E(): 1.5e-17%2C(39.1%25 identity in 169 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical protein Rv0625c.;gbkey=CDS;locus_tag=Rv1491c;product=Conserved membrane protein;protein_id=CCP44252.1;transl_table=11
AL123456.3	EMBL	gene	1682157	1684004	.	+	.	ID=gene-Rv1492;Name=mutA;gbkey=Gene;gene=mutA;gene_biotype=protein_coding;locus_tag=Rv1492
AL123456.3	EMBL	CDS	1682157	1684004	.	+	0	ID=cds-CCP44253.1;Parent=gene-Rv1492;Dbxref=EnsemblGenomes-Gn:Rv1492,EnsemblGenomes-Tr:CCP44253,GOA:P9WJK7,InterPro:IPR004608,InterPro:IPR006099,InterPro:IPR006158,InterPro:IPR014348,InterPro:IPR016176,NCBI_GP:CCP44253.1;Name=CCP44253.1;Note=Rv1492%2C (MTCY277.14)%2C len: 615 aa. Probable mutA%2CMethylmalonyl-CoA mutase small-subunit%2C strong similarity to e.g. MUTA_STRCM|Q05064 methylmalonyl-CoA mutase beta-subunit from Streptomyces cinnamonensis (616 aa)%2CFASTA scores: opt: 1512%2C E(): 0%2C (45.9%25 identity in 628 aa overlap). Contains PS00213 Lipocalin signature%2C PS00544 Methylmalonyl-CoA mutase signature. Belongs to the methylmalonyl-CoA mutase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mutA;inference=protein motif:PROSITE:PS00544;locus_tag=Rv1492;product=Probable methylmalonyl-CoA mutase small subunit MutA (MCM);protein_id=CCP44253.1;transl_table=11
AL123456.3	EMBL	gene	1684005	1686257	.	+	.	ID=gene-Rv1493;Name=mutB;gbkey=Gene;gene=mutB;gene_biotype=protein_coding;locus_tag=Rv1493
AL123456.3	EMBL	CDS	1684005	1686257	.	+	0	ID=cds-CCP44254.1;Parent=gene-Rv1493;Dbxref=EnsemblGenomes-Gn:Rv1493,EnsemblGenomes-Tr:CCP44254,GOA:P9WJK5,InterPro:IPR006098,InterPro:IPR006099,InterPro:IPR006158,InterPro:IPR006159,InterPro:IPR014348,InterPro:IPR016176,PDB:1SE5,NCBI_GP:CCP44254.1;Name=CCP44254.1;Note=Rv1493%2C (MTCY277.15)%2C len: 750 aa. Probable mutB%2CMethylmalonyl-CoA mutase large-subunit%2C strong similarity to e.g. MUTB_STRCM|Q05065 methylmalonyl-CoA mutase alpha-subunit from Streptomyces cinnamonensis (733 aa)%2CFASTA scores: opt: 3562%2C E(): 0%2C (75.8%25 identity in 730 aa overlap). Contains PS00544 Methylmalonyl-CoA mutase signature. Belongs to the methylmalonyl-CoA mutase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mutB;inference=protein motif:PROSITE:PS00544;locus_tag=Rv1493;product=Probable methylmalonyl-CoA mutase large subunit MutB (MCM);protein_id=CCP44254.1;transl_table=11
AL123456.3	EMBL	gene	1686271	1686573	.	+	.	ID=gene-Rv1494;Name=mazE4;gbkey=Gene;gene=mazE4;gene_biotype=protein_coding;locus_tag=Rv1494
AL123456.3	EMBL	CDS	1686271	1686573	.	+	0	ID=cds-CCP44255.1;Parent=gene-Rv1494;Dbxref=EnsemblGenomes-Gn:Rv1494,EnsemblGenomes-Tr:CCP44255,NCBI_GP:CCP44255.1;Name=CCP44255.1;Note=Rv1494%2C (MTCY277.16)%2C len: 100 aa. Possible mazE4%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1495 (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006).;gbkey=CDS;gene=mazE4;locus_tag=Rv1494;product=Possible antitoxin MazE4;protein_id=CCP44255.1;transl_table=11
AL123456.3	EMBL	gene	1686570	1686887	.	+	.	ID=gene-Rv1495;Name=mazF4;gbkey=Gene;gene=mazF4;gene_biotype=protein_coding;gene_synonym=mt7;locus_tag=Rv1495
AL123456.3	EMBL	CDS	1686570	1686887	.	+	0	ID=cds-CCP44256.1;Parent=gene-Rv1495;Dbxref=EnsemblGenomes-Gn:Rv1495,EnsemblGenomes-Tr:CCP44256,GOA:P9WII5,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP44256.1;Name=CCP44256.1;Note=Rv1495%2C (MTCY277.17)%2C len: 105 aa. Possible mazF4%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1494 (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%2C some similarity to Rv1942c|MTCY09F9.22 hypothetical protein from Mycobacterium tuberculosis (109 aa) (0.7%25 identity in 101 aa overlap) and Rv0659c%2C Rv1102c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mazF4;locus_tag=Rv1495;product=Possible toxin MazF4;protein_id=CCP44256.1;transl_table=11
AL123456.3	EMBL	gene	1686884	1687888	.	+	.	ID=gene-Rv1496;Name=Rv1496;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1496
AL123456.3	EMBL	CDS	1686884	1687888	.	+	0	ID=cds-CCP44257.1;Parent=gene-Rv1496;Dbxref=EnsemblGenomes-Gn:Rv1496,EnsemblGenomes-Tr:CCP44257,GOA:P9WPZ1,InterPro:IPR005129,InterPro:IPR027417,PDB:3MD0,PDB:3P32,PDB:4GT1,NCBI_GP:CCP44257.1;Name=CCP44257.1;Note=Rv1496%2C (MTCY277.18)%2C len: 334 aa. Possible transport system kinase. Equivalent to NP_302220.1|NC_002677 putative kinase from Mycobacterium leprae (327 aa). Highly similar to several transport system kinases and NTPase transporters e.g. P27254|ARGK_ECOLI|B2918 LAO/AO transport system kinase from Escherichia coli K12 (331 aa) (see citation below)%3B NP_311815.1|NC_002695 ATPase component of two convergent arginine transporter from Escherichia coli O157:H7 (331 aa)%3B etc. Also similar to YPLE_CAUCR|P37895 hypothetical 34.6 kDa protein in Caulobacter crescentus (326 aa)%2C FASTA scores%2C opt: 1125%2C E(): 0%2C (55.7%25 identity in 316 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1496;product=Possible transport system kinase;protein_id=CCP44257.1;transl_table=11
AL123456.3	EMBL	gene	1687941	1689230	.	+	.	ID=gene-Rv1497;Name=lipL;gbkey=Gene;gene=lipL;gene_biotype=protein_coding;locus_tag=Rv1497
AL123456.3	EMBL	CDS	1687941	1689230	.	+	0	ID=cds-CCP44258.1;Parent=gene-Rv1497;Dbxref=EnsemblGenomes-Gn:Rv1497,EnsemblGenomes-Tr:CCP44258,GOA:P71778,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:P71778,NCBI_GP:CCP44258.1;Name=CCP44258.1;Note=Rv1497%2C (MTCY277.19)%2C len: 429 aa. Probable LipL%2Cesterase%2C very similar to Mycobacterium tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923%2C Rv2463%2C Rv3775%2C etc. Also similar to G151214|M68491 esterase estA from Pseudomonas sp (389 aa)%2C FASTA scores: opt: 604%2C E(): 1e-31%2C (34.4%25 identity in 389 aa overlap).;gbkey=CDS;gene=lipL;locus_tag=Rv1497;product=Probable esterase LipL;protein_id=CCP44258.1;transl_table=11
AL123456.3	EMBL	gene	1689303	1689920	.	-	.	ID=gene-Rv1498c;Name=Rv1498c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1498c
AL123456.3	EMBL	CDS	1689303	1689920	.	-	0	ID=cds-CCP44259.1;Parent=gene-Rv1498c;Dbxref=EnsemblGenomes-Gn:Rv1498c,EnsemblGenomes-Tr:CCP44259,GOA:P9WLW9,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP44259.1;Name=CCP44259.1;Note=Rv1498c%2C (MTCY277.20c)%2C len: 205 aa. Probable methyltransferase. Similar to G2792343|AF040571 methyltransferase from amycolatopsis mediterranei (272 aa)%2CFASTA scores: E(): 5.1e-11%2C (32.3%25 identity in 124 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1498c;product=Probable methyltransferase;protein_id=CCP44259.1;transl_table=11
AL123456.3	EMBL	gene	1690134	1690346	.	-	.	ID=gene-Rv1498A;Name=Rv1498A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1498A
AL123456.3	EMBL	CDS	1690134	1690346	.	-	0	ID=cds-CCP44260.1;Parent=gene-Rv1498A;Dbxref=EnsemblGenomes-Gn:Rv1498A,EnsemblGenomes-Tr:CCP44260,InterPro:IPR009923,InterPro:IPR025543,UniProtKB/TrEMBL:I6XY36,NCBI_GP:CCP44260.1;Name=CCP44260.1;Note=Rv1498A%2C len: 70 aa. Conserved protein%2C highly similar to other hypothetical proteins e.g. from Streptomyces coelicolor%2C Sinorhizobium meliloti and Pseudomonas aeruginosa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1498A;product=Conserved protein;protein_id=CCP44260.1;transl_table=11
AL123456.3	EMBL	gene	1690407	1690805	.	+	.	ID=gene-Rv1499;Name=Rv1499;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1499
AL123456.3	EMBL	CDS	1690407	1690805	.	+	0	ID=cds-CCP44261.1;Parent=gene-Rv1499;Dbxref=EnsemblGenomes-Gn:Rv1499,EnsemblGenomes-Tr:CCP44261,UniProtKB/TrEMBL:P71780,NCBI_GP:CCP44261.1;Name=CCP44261.1;Note=Rv1499%2C (MTCY277.21)%2C len: 132 aa. Hypothetical unknown protein%3B was initially longer but has been shortened (-24 aa) owing to overlap with Rv1498A. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1499;product=Hypothetical protein;protein_id=CCP44261.1;transl_table=11
AL123456.3	EMBL	gene	1690850	1691878	.	+	.	ID=gene-Rv1500;Name=Rv1500;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1500
AL123456.3	EMBL	CDS	1690850	1691878	.	+	0	ID=cds-CCP44262.1;Parent=gene-Rv1500;Dbxref=EnsemblGenomes-Gn:Rv1500,EnsemblGenomes-Tr:CCP44262,GOA:P9WMX5,InterPro:IPR001173,InterPro:IPR029044,NCBI_GP:CCP44262.1;Name=CCP44262.1;Note=Rv1500%2C (MTCY277.22)%2C len: 342 aa. Probable glycosyltransferase%2C hydrophobic domain near C-terminus. Some similarity to putative glycosyl-transferases from Bacillus subtilis e.g. O34319|YKCC_BACSU (323 aa)%2C opt: 490%2C E(): 6.1e-25%2C (28.85%25 identity in 312 aa overlap) and to N-acetyl glucosamine transferases. Also similar to G1001347 hypothetical 36.7 kDa protein (318 aa)%2C FASTA scores: opt: 523%2C E(): 7.2e-26%2C (30.6%25 identity in 307 aa overlap).;gbkey=CDS;locus_tag=Rv1500;product=Probable glycosyltransferase;protein_id=CCP44262.1;transl_table=11
AL123456.3	EMBL	gene	1691890	1692711	.	+	.	ID=gene-Rv1501;Name=Rv1501;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1501
AL123456.3	EMBL	CDS	1691890	1692711	.	+	0	ID=cds-CCP44263.1;Parent=gene-Rv1501;Dbxref=EnsemblGenomes-Gn:Rv1501,EnsemblGenomes-Tr:CCP44263,InterPro:IPR008775,NCBI_GP:CCP44263.1;Name=CCP44263.1;Note=Rv1501%2C (MTCY277.23)%2C len: 273 aa. Conserved hypothetical protein%2C some similarity to O06374|Rv3633|MTCY15C10.19C hypothetical protein from Mycobacterium tuberculosis%2C FASTA scores: E(): 3.9e-10%2C(27.5%25 identity in 280 aa overlap).;gbkey=CDS;locus_tag=Rv1501;product=Conserved hypothetical protein;protein_id=CCP44263.1;transl_table=11
AL123456.3	EMBL	gene	1692924	1693823	.	+	.	ID=gene-Rv1502;Name=Rv1502;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1502
AL123456.3	EMBL	CDS	1692924	1693823	.	+	0	ID=cds-CCP44264.1;Parent=gene-Rv1502;Dbxref=EnsemblGenomes-Gn:Rv1502,EnsemblGenomes-Tr:CCP44264,InterPro:IPR023296,NCBI_GP:CCP44264.1;Name=CCP44264.1;Note=Rv1502%2C (MTCY277.24)%2C len: 299 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1502;product=Hypothetical protein;protein_id=CCP44264.1;transl_table=11
AL123456.3	EMBL	gene	1693996	1694544	.	-	.	ID=gene-Rv1503c;Name=Rv1503c;end_range=1694544,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1503c;partial=true
AL123456.3	EMBL	CDS	1693996	1694544	.	-	0	ID=cds-CCP44265.1;Parent=gene-Rv1503c;Dbxref=EnsemblGenomes-Gn:Rv1503c,EnsemblGenomes-Tr:CCP44265,GOA:L0T8G4,InterPro:IPR000653,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:L0T8G4,NCBI_GP:CCP44265.1;Name=CCP44265.1;Note=Rv1503c%2C (MTCY277.25c)%2C len: 182 aa. Conserved hypothetical protein%2C similar to C-terminal region of P27833|RFFA_ECOLI lipopolysaccharide biosynthesis protein from Escherichia coli (376 aa)%2C FASTA scores: opt: 565%2CE(): 0%2C (49.4%25 identity in 170 aa overlap)%3B Rv1503c and Rv1504c are both similar to RFFA_ECOLI but are separated by a stop codon%2C sequence appears to be correct so possible pseudogene.;end_range=1694544,.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1503c;partial=true;product=Conserved hypothetical protein;protein_id=CCP44265.1;transl_table=11
AL123456.3	EMBL	gene	1694545	1695144	.	-	.	ID=gene-Rv1504c;Name=Rv1504c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1504c
AL123456.3	EMBL	CDS	1694545	1695144	.	-	0	ID=cds-CCP44266.1;Parent=gene-Rv1504c;Dbxref=EnsemblGenomes-Gn:Rv1504c,EnsemblGenomes-Tr:CCP44266,GOA:L0T6V0,InterPro:IPR000653,InterPro:IPR015421,InterPro:IPR015424,UniProtKB/TrEMBL:L0T6V0,NCBI_GP:CCP44266.1;Name=CCP44266.1;Note=Rv1504c%2C (MTCY277.26c)%2C len: 199 aa. Conserved hypothetical protein%2C similar to N-terminal region of P27833|RFFA_ECOLI lipopolysaccharide biosynthesis protein from Escherichia coli (376 aa)%2C FASTA scores: opt: 863%2CE(): 0%2C (68.0%25 identity in 194 aa overlap)%3B Rv1503c and Rv1504c are similar to RFFA_ECOLI but are separated by a stop codon%2C sequence appears to be correct so possible pseudogene.;gbkey=CDS;locus_tag=Rv1504c;product=Conserved hypothetical protein;protein_id=CCP44266.1;transl_table=11
AL123456.3	EMBL	gene	1695281	1695946	.	-	.	ID=gene-Rv1505c;Name=Rv1505c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1505c
AL123456.3	EMBL	CDS	1695281	1695946	.	-	0	ID=cds-CCP44267.1;Parent=gene-Rv1505c;Dbxref=EnsemblGenomes-Gn:Rv1505c,EnsemblGenomes-Tr:CCP44267,GOA:P71784,InterPro:IPR001451,InterPro:IPR011004,InterPro:IPR020019,UniProtKB/TrEMBL:P71784,NCBI_GP:CCP44267.1;Name=CCP44267.1;Note=Rv1505c%2C (MTCY277.27c)%2C len: 221 aa. Conserved hypothetical protein%2C some similarity to hypothetical proteins and glycosylases e.g. P71063|O08181 hypothetical 22.5 kDa protein YVFD from Bacillus subtilis (216 aa)%2CFASTA scores: E(): 2.4e-08%2C (25.5%25 identity in 196 aa overlap).;gbkey=CDS;locus_tag=Rv1505c;product=Conserved hypothetical protein;protein_id=CCP44267.1;transl_table=11
AL123456.3	EMBL	gene	1695943	1696443	.	-	.	ID=gene-Rv1506c;Name=Rv1506c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1506c
AL123456.3	EMBL	CDS	1695943	1696443	.	-	0	ID=cds-CCP44268.1;Parent=gene-Rv1506c;Dbxref=EnsemblGenomes-Gn:Rv1506c,EnsemblGenomes-Tr:CCP44268,GOA:P71785,InterPro:IPR013217,InterPro:IPR026635,InterPro:IPR029063,UniProtKB/TrEMBL:P71785,NCBI_GP:CCP44268.1;Name=CCP44268.1;Note=Rv1506c%2C (MTCY277.28c)%2C len: 166 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1506c;product=Hypothetical protein;protein_id=CCP44268.1;transl_table=11
AL123456.3	EMBL	gene	1696727	1697422	.	-	.	ID=gene-Rv1507c;Name=Rv1507c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1507c
AL123456.3	EMBL	CDS	1696727	1697422	.	-	0	ID=cds-CCP44269.1;Parent=gene-Rv1507c;Dbxref=EnsemblGenomes-Gn:Rv1507c,EnsemblGenomes-Tr:CCP44269,GOA:P9WLW5,InterPro:IPR014985,NCBI_GP:CCP44269.1;Name=CCP44269.1;Note=Rv1507c%2C (MTCY277.29c)%2C len: 231 aa. Conserved protein. Similar to AJ007747|BBR007747_6 Hypothetical protein BbLPS1.06 from Bordetella bronchiseptica cosmid (239 aa)%2C FASTA scores: opt: 362%2C E(): 1.3e-17%2C (30.8%25 identity in 221 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1507c;product=Conserved protein;protein_id=CCP44269.1;transl_table=11
AL123456.3	EMBL	gene	1697356	1697859	.	+	.	ID=gene-Rv1507A;Name=Rv1507A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1507A
AL123456.3	EMBL	CDS	1697356	1697859	.	+	0	ID=cds-CCP44270.1;Parent=gene-Rv1507A;Dbxref=EnsemblGenomes-Gn:Rv1507A,EnsemblGenomes-Tr:CCP44270,UniProtKB/TrEMBL:L7N6B6,NCBI_GP:CCP44270.1;Name=CCP44270.1;Note=Rv1507A%2C len: 167 aa. Hypothetical unknow protein. Shows weak similarity with C-terminus of Q9XHQ7|CDA9 cytidine deaminase 9 from Arabidopsis thaliana (Mouse-ear cress) (298 aa)%2C FASTA scores: opt: 104%2C E(): 4.2%2C (33.6%25 identity in 133 aa overlap)%2C blastp scores: Score: 77%2CIdentities: 39/133 (29%25)%2C Positives: 62/133 (46%25).;gbkey=CDS;locus_tag=Rv1507A;product=Hypothetical protein;protein_id=CCP44270.1;transl_table=11
AL123456.3	EMBL	gene	1698095	1699894	.	-	.	ID=gene-Rv1508c;Name=Rv1508c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1508c
AL123456.3	EMBL	CDS	1698095	1699894	.	-	0	ID=cds-CCP44271.1;Parent=gene-Rv1508c;Dbxref=EnsemblGenomes-Gn:Rv1508c,EnsemblGenomes-Tr:CCP44271,GOA:P71787,InterPro:IPR018584,UniProtKB/TrEMBL:P71787,NCBI_GP:CCP44271.1;Name=CCP44271.1;Note=Rv1508c%2C (MTCY277.30c)%2C len: 599 aa. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Probable membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1508c;product=Probable membrane protein;protein_id=CCP44271.1;transl_table=11
AL123456.3	EMBL	gene	1699866	1700228	.	+	.	ID=gene-Rv1508A;Name=Rv1508A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1508A
AL123456.3	EMBL	CDS	1699866	1700228	.	+	0	ID=cds-CCP44272.1;Parent=gene-Rv1508A;Dbxref=EnsemblGenomes-Gn:Rv1508A,EnsemblGenomes-Tr:CCP44272,UniProtKB/TrEMBL:Q79FN0,NCBI_GP:CCP44272.1;Name=CCP44272.1;Note=Rv1508A%2C len: 120 aa. Conserved hypothetical protein%2C highly similar to central part of glycosyl transferases from various mycobacteria and eubacteria e.g. P71790|MTCY277.33|Rv1511 Hypothetical protein from M. tuberculosis (340 aa)%2C FASTA scores: opt: 210%2C E(): 2.5 e-09%2C (42.9%25 identity in 105 aa overlap).;gbkey=CDS;locus_tag=Rv1508A;product=Conserved hypothetical protein;protein_id=CCP44272.1;transl_table=11
AL123456.3	EMBL	gene	1700212	1701093	.	+	.	ID=gene-Rv1509;Name=Rv1509;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1509
AL123456.3	EMBL	CDS	1700212	1701093	.	+	0	ID=cds-CCP44273.1;Parent=gene-Rv1509;Dbxref=EnsemblGenomes-Gn:Rv1509,EnsemblGenomes-Tr:CCP44273,GOA:P9WLW3,InterPro:IPR010233,InterPro:IPR029063,NCBI_GP:CCP44273.1;Name=CCP44273.1;Note=Rv1509%2C (MTCY277.31)%2C len: 293 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1509;product=Hypothetical protein;protein_id=CCP44273.1;transl_table=11
AL123456.3	EMBL	gene	1701295	1702593	.	+	.	ID=gene-Rv1510;Name=Rv1510;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1510
AL123456.3	EMBL	CDS	1701295	1702593	.	+	0	ID=cds-CCP44274.1;Parent=gene-Rv1510;Dbxref=EnsemblGenomes-Gn:Rv1510,EnsemblGenomes-Tr:CCP44274,GOA:P9WLW1,NCBI_GP:CCP44274.1;Name=CCP44274.1;Note=Rv1510%2C (MTCY277.32)%2C len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa)%2CFASTA scores: E(): 0%2C (70.8%25 identity in 424 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1510;product=Conserved probable membrane protein;protein_id=CCP44274.1;transl_table=11
AL123456.3	EMBL	gene	1703074	1704096	.	+	.	ID=gene-Rv1511;Name=gmdA;gbkey=Gene;gene=gmdA;gene_biotype=protein_coding;locus_tag=Rv1511
AL123456.3	EMBL	CDS	1703074	1704096	.	+	0	ID=cds-CCP44275.1;Parent=gene-Rv1511;Dbxref=EnsemblGenomes-Gn:Rv1511,EnsemblGenomes-Tr:CCP44275,GOA:P71790,InterPro:IPR001509,InterPro:IPR006368,InterPro:IPR016040,UniProtKB/TrEMBL:P71790,NCBI_GP:CCP44275.1;Name=CCP44275.1;Note=Rv1511%2C (MTCY277.33)%2C len: 340 aa. Probable gmdA%2CGDP-D-mannose dehydratase%2C equivalent to AF125999|AF125999_13 Mycobacterium avium enzyme (343 aa)%2CFASTA scores: opt: 2085%2C E(): 0%2C (89.1%25 identity in 338 aa overlap)%3B similar to G755218 pseudomonas aeruginosa GDP-D-mannose dehydratase (GCA) (323 aa)%2C FASTA scores: opt: 1073%2C E(): 0%2C (51.9%25 identity in 320 aa overlap)%3B and to S74433 GDP-D-mannose dehydratase rfbD - Syn (362 aa)%2CFASTA scores: opt: 1405%2C E(): 0%2C (63.9%25 identity in 327 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gmdA;locus_tag=Rv1511;product=GDP-D-mannose dehydratase GmdA (GDP-mannose 4%2C6 dehydratase) (GMD);protein_id=CCP44275.1;transl_table=11
AL123456.3	EMBL	gene	1704093	1705061	.	+	.	ID=gene-Rv1512;Name=epiA;gbkey=Gene;gene=epiA;gene_biotype=protein_coding;locus_tag=Rv1512
AL123456.3	EMBL	CDS	1704093	1705061	.	+	0	ID=cds-CCP44276.1;Parent=gene-Rv1512;Dbxref=EnsemblGenomes-Gn:Rv1512,EnsemblGenomes-Tr:CCP44276,GOA:P71791,InterPro:IPR001509,InterPro:IPR016040,InterPro:IPR028614,UniProtKB/TrEMBL:P71791,NCBI_GP:CCP44276.1;Name=CCP44276.1;Note=Rv1512%2C (MTCY277.34)%2C len: 322 aa. Probable epiA%2Cnucleotide sugar epimerase%2C equivalent to AJ223832|MAS223832_4 from Mycobacterium avium silvaticum (339 aa)%2C FASTA scores: opt: 1821%2C E(): 0%2C (84.6%25 identity in 318 aa overlap)%3B and similar to WCAG_ECOLI|P32055 colanic acid biosynthesis protein wcaG (321 aa)%2C FASTA scores: opt: 835%2C E(): 0%2C (53.5%25 identity in 316 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=epiA;locus_tag=Rv1512;product=Probable nucleotide-sugar epimerase EpiA;protein_id=CCP44276.1;transl_table=11
AL123456.3	EMBL	gene	1705058	1705789	.	+	.	ID=gene-Rv1513;Name=Rv1513;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1513
AL123456.3	EMBL	CDS	1705058	1705789	.	+	0	ID=cds-CCP44277.1;Parent=gene-Rv1513;Dbxref=EnsemblGenomes-Gn:Rv1513,EnsemblGenomes-Tr:CCP44277,GOA:P71792,InterPro:IPR006342,InterPro:IPR029063,UniProtKB/TrEMBL:P71792,NCBI_GP:CCP44277.1;Name=CCP44277.1;Note=Rv1513%2C (MTCY277.35)%2C len: 243 aa. Conserved protein%2C similar to hypothetical proteins from several organisms e.g. AJ223833|MAP223833_3 from Mycobacterium avium paratuberculosis (240 aa)%2C FASTA scores: opt: 1053 E(): 0%2C (66.3%25 identity in 243 aa overlap)%3B P74191|SLL1173 from Synechocystis (244 aa)%2C FASTA scores: opt: 276%2C E(): 1.1e-07%2C (32.2 %25 identity in 202 aa overlap). Also highly similar to P95136|Q50460|MTCY349.33c|Rv2956 from Mycobacterium tuberculosis (243 aa)%2C (70.0%25 identity in 237 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1513;product=Conserved protein;protein_id=CCP44277.1;transl_table=11
AL123456.3	EMBL	gene	1705807	1706595	.	-	.	ID=gene-Rv1514c;Name=Rv1514c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1514c
AL123456.3	EMBL	CDS	1705807	1706595	.	-	0	ID=cds-CCP44278.1;Parent=gene-Rv1514c;Dbxref=EnsemblGenomes-Gn:Rv1514c,EnsemblGenomes-Tr:CCP44278,GOA:P9WMX9,InterPro:IPR001173,InterPro:IPR029044,NCBI_GP:CCP44278.1;Name=CCP44278.1;Note=Rv1514c%2C (MTCY277.36c)%2C len: 262 aa. Conserved hypothetical protein. Similar to other hypothetical proteins%2C and to WCAE_ECOLI|P71239 putative colanic acid biosynthesis glycosyl transferase (248 aa)%2C FASTA scores: opt: 231%2C E(): 4.1e-08%2C (33.3%25 identity in 210 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical glycosyltransferase%2C Rv2957.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1514c;product=Conserved hypothetical protein;protein_id=CCP44278.1;transl_table=11
AL123456.3	EMBL	gene	1706630	1707526	.	-	.	ID=gene-Rv1515c;Name=Rv1515c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1515c
AL123456.3	EMBL	CDS	1706630	1707526	.	-	0	ID=cds-CCP44279.1;Parent=gene-Rv1515c;Dbxref=EnsemblGenomes-Gn:Rv1515c,EnsemblGenomes-Tr:CCP44279,GOA:P71794,InterPro:IPR029063,UniProtKB/TrEMBL:P71794,NCBI_GP:CCP44279.1;Name=CCP44279.1;Note=Rv1515c%2C (MTCY277.37c)%2C len: 298 aa. Conserved hypothetical protein%2C similar to P71805|MTCY02B12.11C|Rv1377c Hypothetical protein from Mycobacterium tuberculosis%2C FASTA scores: E(): 1.3e-05%2C(25.4%25 identity in 134 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1515c;product=Conserved hypothetical protein;protein_id=CCP44279.1;transl_table=11
AL123456.3	EMBL	gene	1707529	1708539	.	-	.	ID=gene-Rv1516c;Name=Rv1516c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1516c
AL123456.3	EMBL	CDS	1707529	1708539	.	-	0	ID=cds-CCP44280.1;Parent=gene-Rv1516c;Dbxref=EnsemblGenomes-Gn:Rv1516c,EnsemblGenomes-Tr:CCP44280,GOA:P71795,InterPro:IPR001173,InterPro:IPR029044,UniProtKB/TrEMBL:P71795,NCBI_GP:CCP44280.1;Name=CCP44280.1;Note=Rv1516c%2C (MTCY277.38c)%2C len: 336 aa. Probable sugar transferase%2C similar to AB010970|AB010970_6 glycosyltransferase from Streptococcus mutans (465 aa)%2CFASTA scores: opt: 388%2C E(): 4.1e-18%2C (32.7%25 identity in 214 aa overlap)%2C slight similarity to SPSA_BACSU|P39621 spore coat polysaccharide biosynthesis (256 aa)%2C fasta scores: opt: 185%2C E(): 6.5e-05%2C (26.2%25 identity in 187 aa overlap)%2C strong similarity to Rv1520|MTCY19G5.08c probable sugar transferase from Mycobacterium tuberculosis (63.5%25 identity in 318 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1516c;product=Probable sugar transferase;protein_id=CCP44280.1;transl_table=11
AL123456.3	EMBL	gene	1708871	1709635	.	+	.	ID=gene-Rv1517;Name=Rv1517;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1517
AL123456.3	EMBL	CDS	1708871	1709635	.	+	0	ID=cds-CCP44281.1;Parent=gene-Rv1517;Dbxref=EnsemblGenomes-Gn:Rv1517,EnsemblGenomes-Tr:CCP44281,GOA:P71796,InterPro:IPR021315,UniProtKB/TrEMBL:P71796,NCBI_GP:CCP44281.1;Name=CCP44281.1;Note=Rv1517%2C (MTCY277.39)%2C len: 254 aa. Conserved hypothetical transmembrane protein%2C similar to G466802|LEPB1170_F2_64 from Mycobacterium leprae (230 aa)%2CFASTA scores: opt: 282%2C E(): 2.2e-11%2C (34.1%25 identity in 255 aa overlap). Also similar to Mycobacterium tuberculosis Rv3821|MTCY409.09c (237 aa) (36.3%25 identity in 256 aa overlap)%3B and Rv3481c.;gbkey=CDS;locus_tag=Rv1517;product=Conserved hypothetical transmembrane protein;protein_id=CCP44281.1;transl_table=11
AL123456.3	EMBL	gene	1709644	1710603	.	+	.	ID=gene-Rv1518;Name=Rv1518;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1518
AL123456.3	EMBL	CDS	1709644	1710603	.	+	0	ID=cds-CCP44282.1;Parent=gene-Rv1518;Dbxref=EnsemblGenomes-Gn:Rv1518,EnsemblGenomes-Tr:CCP44282,GOA:P9WLV9,InterPro:IPR001173,InterPro:IPR029044,NCBI_GP:CCP44282.1;Name=CCP44282.1;Note=Rv1518%2C (MTCY277.40%2C MTCY19G5.11c)%2C len: 319 aa. Conserved hypothetical protein%2C possibly glycosyl transferase involved in exopolysaccharide synthesis%2Csimilar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from synecho cystis sp. (309 aa)%2C Fasta scores: opt: 300%2C E(): 1.8e-13%2C (29.5%25 identity in 241 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1518;product=Conserved hypothetical protein;protein_id=CCP44282.1;transl_table=11
AL123456.3	EMBL	gene	1710733	1711002	.	+	.	ID=gene-Rv1519;Name=Rv1519;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1519
AL123456.3	EMBL	CDS	1710733	1711002	.	+	0	ID=cds-CCP44283.1;Parent=gene-Rv1519;Dbxref=EnsemblGenomes-Gn:Rv1519,EnsemblGenomes-Tr:CCP44283,GOA:P9WLV7,InterPro:IPR000653,InterPro:IPR015422,NCBI_GP:CCP44283.1;Name=CCP44283.1;Note=Rv1519%2C (MTCY19G5.09c)%2C len: 89 aa. Conserved hypothetical protein%2C high similarity to C-terminus of Q50723|MTCY78.26|Rv3402c (412 aa) (58.1%25 identity in 74 aa overlap).;gbkey=CDS;locus_tag=Rv1519;product=Conserved hypothetical protein;protein_id=CCP44283.1;transl_table=11
AL123456.3	EMBL	gene	1711028	1712068	.	+	.	ID=gene-Rv1520;Name=Rv1520;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1520
AL123456.3	EMBL	CDS	1711028	1712068	.	+	0	ID=cds-CCP44284.1;Parent=gene-Rv1520;Dbxref=EnsemblGenomes-Gn:Rv1520,EnsemblGenomes-Tr:CCP44284,GOA:P9WLV5,InterPro:IPR001173,InterPro:IPR029044,NCBI_GP:CCP44284.1;Name=CCP44284.1;Note=Rv1520%2C (MTCY19G5.08c)%2C len: 346 aa. Probable sugar transferase%2C similar to several e.g. AB010970|AB010970_6 Streptococcus mutans glycosyltransferase (465 aa)%2C FASTA scores: opt: 381%2C E(): 1.2e-18%2C (31.7%25 identity in 240 aa overlap)%3B O34234|Y07786 sugar transferase from Vibrio cholerae (337 aa)%2C FASTA scores: opt: 214%2C E(): 8.4e-05%2C(25.9%25 identity in 212 aa overlap). Also strongly similar to Mycobacterium tuberculosis probable sugar transferase Rv1516c. Alternative nucleotide at position 1711627 (C->T%3B Y200Y) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1520;product=Probable sugar transferase;protein_id=CCP44284.1;transl_table=11
AL123456.3	EMBL	gene	1712302	1714053	.	+	.	ID=gene-Rv1521;Name=fadD25;gbkey=Gene;gene=fadD25;gene_biotype=protein_coding;locus_tag=Rv1521
AL123456.3	EMBL	CDS	1712302	1714053	.	+	0	ID=cds-CCP44285.1;Parent=gene-Rv1521;Dbxref=EnsemblGenomes-Gn:Rv1521,EnsemblGenomes-Tr:CCP44285,GOA:P9WQ45,InterPro:IPR000873,NCBI_GP:CCP44285.1;Name=CCP44285.1;Note=Rv1521%2C (MTCY19G5.07)%2C len: 583 aa. Probable fadD25%2Cfatty-acid-AMP synthetase%2C highly similar to many e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa)%2C FASTA scores: opt: 2486%2C E(): 0%2C (63.4%25 identity in 584 aa overlap)%3B NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa)%3B fadD28 (580 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD25;locus_tag=Rv1521;product=Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP44285.1;transl_table=11
AL123456.3	EMBL	gene	1714172	1717612	.	-	.	ID=gene-Rv1522c;Name=mmpL12;gbkey=Gene;gene=mmpL12;gene_biotype=protein_coding;locus_tag=Rv1522c
AL123456.3	EMBL	CDS	1714172	1717612	.	-	0	ID=cds-CCP44286.1;Parent=gene-Rv1522c;Dbxref=EnsemblGenomes-Gn:Rv1522c,EnsemblGenomes-Tr:CCP44286,GOA:P9WJT7,InterPro:IPR000731,InterPro:IPR004707,InterPro:IPR004869,NCBI_GP:CCP44286.1;Name=CCP44286.1;Note=Rv1522c%2C (MTCY19G5.06)%2C len: 1146 aa. Probable mmpL12%2C conserved transmembrane transport protein (see Tekaia et al.%2C 1999)%2C member of RND superfamily. Strong similarity to many Mycobacterial membrane proteins e.g. Q49619|G466786 putative transport protein B1170_C1_181 from Mycobacterium leprae (1008 aa)%2C FASTA scores: opt: 2418%2CE(): 0%2C (51.0%25 identity in 1006 aa overlap)%3B etc. Also highly similar to MmpL8|MTCY48.08c|Rv3823c probable conserved transmembrane transport protein from Mycobacterium tuberculosis%2C FASTA score: (34.3%25 identity in 376 aa overlap)%3B and some similarity to MmpL10|MTCY20G9|Rv1183 probable conserved transmembrane transport protein%2C FASTA score: (27.2%25 identity in 1011 aa overlap). Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL12;locus_tag=Rv1522c;product=Probable conserved transmembrane transport protein MmpL12;protein_id=CCP44286.1;transl_table=11
AL123456.3	EMBL	gene	1717653	1718696	.	+	.	ID=gene-Rv1523;Name=Rv1523;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1523
AL123456.3	EMBL	CDS	1717653	1718696	.	+	0	ID=cds-CCP44287.1;Parent=gene-Rv1523;Dbxref=EnsemblGenomes-Gn:Rv1523,EnsemblGenomes-Tr:CCP44287,GOA:Q50584,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:Q50584,NCBI_GP:CCP44287.1;Name=CCP44287.1;Note=Rv1523%2C (MTCY19G5.05c)%2C len: 347 aa (start uncertain). Probable methyltransferase%2C similar to G560513|U0002O Mycobacterium leprae (270 aa)%2C FASTA scores: opt: 965%2C E(): 0%2C (60.3%25 identity in 247 aa overlap). Also similar to many e.g. Q54303|X86780 methyltransferase RAPM from Streptomyces hygroscopicus (317 aa)%2C FASTA scores: opt: 323%2C E(): 1e-15%2C (41.2%25 identity in 136 aa overlap). And similar to M. tuberculosis hypothetical proteins Rv2952%2C Rv1405c%2C Rv1403c%2C Rv0839.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1523;product=Probable methyltransferase;protein_id=CCP44287.1;transl_table=11
AL123456.3	EMBL	gene	1718726	1719970	.	+	.	ID=gene-Rv1524;Name=Rv1524;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1524
AL123456.3	EMBL	CDS	1718726	1719970	.	+	0	ID=cds-CCP44288.1;Parent=gene-Rv1524;Dbxref=EnsemblGenomes-Gn:Rv1524,EnsemblGenomes-Tr:CCP44288,GOA:P9WN07,InterPro:IPR002213,InterPro:IPR004276,NCBI_GP:CCP44288.1;Name=CCP44288.1;Note=Rv1524%2C (MTCY19G5.04c)%2C len: 414 aa. Probable glycosyltransferase%2C similar to many e.g. P96559|U84349 glycosyltransferase GTFB from Amycolatopsis orientalis (407 aa)%2C FASTA scores: opt: 363%2C E(): 6.2e-23%2C (28.8%25 identity in 430 aa overlap)%3B also high similarity to Rv1526c|MTCY19G5.02 Mycobacterium tuberculosis hypothetical protein (58.7%25 identity in 416 aa overlap)%3B and AF143772|AF143772_15 glycosyltransferase gtfB from Mycobacterium avium strain 215 (418 aa)%2C FASTA scores: opt: 1801%2C E(): 0%2C (65.2%25 identity in 417 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1524;product=Probable glycosyltransferase;protein_id=CCP44288.1;transl_table=11
AL123456.3	EMBL	gene	1720017	1720802	.	+	.	ID=gene-Rv1525;Name=wbbL2;gbkey=Gene;gene=wbbL2;gene_biotype=protein_coding;locus_tag=Rv1525
AL123456.3	EMBL	CDS	1720017	1720802	.	+	0	ID=cds-CCP44289.1;Parent=gene-Rv1525;Dbxref=EnsemblGenomes-Gn:Rv1525,EnsemblGenomes-Tr:CCP44289,InterPro:IPR029044,NCBI_GP:CCP44289.1;Name=CCP44289.1;Note=Rv1525%2C (MT1576%2C MTCY19G5.03c)%2C len: 261 aa. Possible wbbL2%2C rhamnosyl transferase (see citation below)%2Cshowing weak similarity to several rhamnosyl transferases. Similar to AF105060|AF105060_1 Riftia pachyptila endosymbiont (746 aa)%2C FASTA scores: opt: 183%2C E(): 0.00013%2C (35.2%25 identity in 105 aa overlap).;gbkey=CDS;gene=wbbL2;locus_tag=Rv1525;product=Possible rhamnosyl transferase WbbL2;protein_id=CCP44289.1;transl_table=11
AL123456.3	EMBL	gene	1720780	1722060	.	-	.	ID=gene-Rv1526c;Name=Rv1526c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1526c
AL123456.3	EMBL	CDS	1720780	1722060	.	-	0	ID=cds-CCP44290.1;Parent=gene-Rv1526c;Dbxref=EnsemblGenomes-Gn:Rv1526c,EnsemblGenomes-Tr:CCP44290,GOA:P9WLV1,InterPro:IPR002213,InterPro:IPR004276,NCBI_GP:CCP44290.1;Name=CCP44290.1;Note=Rv1526c%2C (MTCY19G5.02)%2C len: 426 aa. Probable glycosyltransferase%2C highly similar to G467196 Protein L518_C2_147 from Mycobacterium leprae (421 aa)%2C FASTA scores%2C opt: 1497%2C E(): 0%2C (55.0%25 identity in 424 aa overlap)%3B similar to G452504 rhamnosyltransferase (24.7%25 identity in 433 aa overlap)%3B and P96565|U84350 glycosyltransferase GTFE from Amycolatopsis orientalis (408 aa)%2C E(): 3.4e-24%2C (28.4%25 identity in 429 aa overlap)%2C also high similarity to Rv1524|MTCY19G5.04c (58.7 %25 identity in 416 aa overlap).;gbkey=CDS;locus_tag=Rv1526c;product=Probable glycosyltransferase;protein_id=CCP44290.1;transl_table=11
AL123456.3	EMBL	gene	1722083	1728409	.	-	.	ID=gene-Rv1527c;Name=pks5;gbkey=Gene;gene=pks5;gene_biotype=protein_coding;locus_tag=Rv1527c
AL123456.3	EMBL	CDS	1722083	1728409	.	-	0	ID=cds-CCP44291.1;Parent=gene-Rv1527c;Dbxref=EnsemblGenomes-Gn:Rv1527c,EnsemblGenomes-Tr:CCP44291,GOA:O53901,InterPro:IPR001227,InterPro:IPR002198,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020807,InterPro:IPR020842,InterPro:IPR020843,UniProtKB/TrEMBL:O53901,NCBI_GP:CCP44291.1;Name=CCP44291.1;Note=Rv1527c%2C (MTV045.01c-MTCY19G5.01)%2C len: 2108 aa. Probable pks5%2C polyketide synthase%2C highly similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from Mycobacterium bovis (2110 aa)%2C FASTA scores: opt: 6270%2CE(): 0%2C (63.6%25 identity in 2126 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks5;locus_tag=Rv1527c;product=Probable polyketide synthase Pks5;protein_id=CCP44291.1;transl_table=11
AL123456.3	EMBL	gene	1728953	1729450	.	-	.	ID=gene-Rv1528c;Name=papA4;gbkey=Gene;gene=papA4;gene_biotype=protein_coding;locus_tag=Rv1528c
AL123456.3	EMBL	CDS	1728953	1729450	.	-	0	ID=cds-CCP44292.1;Parent=gene-Rv1528c;Dbxref=EnsemblGenomes-Gn:Rv1528c,EnsemblGenomes-Tr:CCP44292,UniProtKB/TrEMBL:O53902,NCBI_GP:CCP44292.1;Name=CCP44292.1;Note=Rv1528c%2C (MTV045.02)%2C len: 165 aa. Probable papA4%2Cconserved polyketide synthase (PKS) associated protein%3B shows some similarity to C-terminal part of hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. Z97188|MTCY409_10 Mycobacterium tuberculosis cosmid (468) (37.9%25 identity in 66 aa overlap)%3B or U00010_11 Mycobacterium leprae cosmid B1170 (35.7%25 identity in 84 aa overlap). Also similar to Mycobacterium tuberculosis PKS-associated proteins Rv1182%2C Rv3824c%2CRv3820c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=papA4;locus_tag=Rv1528c;product=Probable conserved polyketide synthase associated protein PapA4;protein_id=CCP44292.1;transl_table=11
AL123456.3	EMBL	gene	1729502	1731256	.	+	.	ID=gene-Rv1529;Name=fadD24;gbkey=Gene;gene=fadD24;gene_biotype=protein_coding;locus_tag=Rv1529
AL123456.3	EMBL	CDS	1729502	1731256	.	+	0	ID=cds-CCP44293.1;Parent=gene-Rv1529;Dbxref=EnsemblGenomes-Gn:Rv1529,EnsemblGenomes-Tr:CCP44293,GOA:O53903,InterPro:IPR000873,UniProtKB/TrEMBL:O53903,NCBI_GP:CCP44293.1;Name=CCP44293.1;Note=Rv1529%2C (MTV045.03)%2C len: 584 aa. Probable fadD24%2Cfatty-acid-AMP synthetase%2C highly similar to many e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa)%2C FASTA score: (65.6%25 identity in 582 aa overlap)%3B and many other fatty-acid-CoA synthetases from Mycobacteria e.g. fadD25|MTCY19G5_7 from Mycobacterium tuberculosis (583 aa)%2C FASTA score: (68.7%25 identity in 584 aa overlap)%3B fadD28|MTCY24G1_8 from Mycobacterium tuberculosis (580 aa)%2C FASTA score: (66.0%25 identity in 582 aa overlap)%3B NP_301232.1|NC_002677|U00010_6 from Mycobacterium leprae (372 aa)%2C FASTA score: (57.6%25 identity in 342 aa overlap)%3B FADD23|Rv3826|MTCY409.04c from Mycobacterium tuberculosis (584 aa)%2C FASTA score: (63.2%25 identity in 584 aa overlap)%3B etc.;gbkey=CDS;gene=fadD24;locus_tag=Rv1529;product=Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP44293.1;transl_table=11
AL123456.3	EMBL	gene	1731373	1732476	.	+	.	ID=gene-Rv1530;Name=adh;gbkey=Gene;gene=adh;gene_biotype=protein_coding;locus_tag=Rv1530
AL123456.3	EMBL	CDS	1731373	1732476	.	+	0	ID=cds-CCP44294.1;Parent=gene-Rv1530;Dbxref=EnsemblGenomes-Gn:Rv1530,EnsemblGenomes-Tr:CCP44294,GOA:P9WQC3,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,NCBI_GP:CCP44294.1;Name=CCP44294.1;Note=Rv1530%2C (MTV045.04)%2C len: 367 aa. Probable adh%2Calcohol dehydrogenase%2C zinc-dependent%2C similar to many e.g. AE0009|AE000958_23 Archaeoglobus fulgidus section 1 (402 aa)%2C FASTA scores: opt: 423%2C E(): 1.8e-19%2C (31.7%25 identity in 341 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adh;inference=protein motif:PROSITE:PS00059;locus_tag=Rv1530;product=Probable alcohol dehydrogenase Adh;protein_id=CCP44294.1;transl_table=11
AL123456.3	EMBL	gene	1732473	1733039	.	+	.	ID=gene-Rv1531;Name=Rv1531;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1531
AL123456.3	EMBL	CDS	1732473	1733039	.	+	0	ID=cds-CCP44295.1;Parent=gene-Rv1531;Dbxref=EnsemblGenomes-Gn:Rv1531,EnsemblGenomes-Tr:CCP44295,GOA:O53905,InterPro:IPR003779,InterPro:IPR029032,UniProtKB/TrEMBL:O53905,NCBI_GP:CCP44295.1;Name=CCP44295.1;Note=Rv1531%2C (MTV045.05)%2C len: 188 aa. Conserved protein%2Csimilar to Rv0464c|MTV038.08c (190 aa)%2C FASTA scores: E(): 4.8e-10%2C (30.9%25 identity in 175 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1531;product=Conserved protein;protein_id=CCP44295.1;transl_table=11
AL123456.3	EMBL	gene	1733116	1733550	.	-	.	ID=gene-Rv1532c;Name=Rv1532c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1532c
AL123456.3	EMBL	CDS	1733116	1733550	.	-	0	ID=cds-CCP44296.1;Parent=gene-Rv1532c;Dbxref=EnsemblGenomes-Gn:Rv1532c,EnsemblGenomes-Tr:CCP44296,InterPro:IPR003736,InterPro:IPR006683,InterPro:IPR029069,UniProtKB/TrEMBL:O06178,NCBI_GP:CCP44296.1;Name=CCP44296.1;Note=Rv1532c%2C (MTCY07A7A.01c)%2C len: 144 aa. Conserved hypothetical protein%2C similar to P20378|YPHR_HALHA Hypothetical 15.6 kDa protein from Halobacterium halobium (151 aa)%2C FASTA scores: opt: 152%2C E():4.5e-05%2C (30.1%25 identity in 103 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1532c;product=Conserved hypothetical protein;protein_id=CCP44296.1;transl_table=11
AL123456.3	EMBL	gene	1733610	1734737	.	+	.	ID=gene-Rv1533;Name=Rv1533;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1533
AL123456.3	EMBL	CDS	1733610	1734737	.	+	0	ID=cds-CCP44297.1;Parent=gene-Rv1533;Dbxref=EnsemblGenomes-Gn:Rv1533,EnsemblGenomes-Tr:CCP44297,GOA:O06179,InterPro:IPR004136,InterPro:IPR013785,NCBI_GP:CCP44297.1;Name=CCP44297.1;Note=Rv1533%2C (MTCY07A7A.02)%2C len: 375 aa. Conserved protein. Similar to 2NPD_NEUCR|Q01284 2-nitropropane dioxygenase precursor (378 aa)%2C fasta scores: opt: 279%2CE(): 9.1e-11%2C (31.3%25 identity in 256 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1894c%2C Rv0021c%2C Rv3553%2C Rv2781c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1533;product=Conserved protein;protein_id=CCP44297.1;transl_table=11
AL123456.3	EMBL	gene	1734734	1735411	.	+	.	ID=gene-Rv1534;Name=Rv1534;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1534
AL123456.3	EMBL	CDS	1734734	1735411	.	+	0	ID=cds-CCP44298.1;Parent=gene-Rv1534;Dbxref=EnsemblGenomes-Gn:Rv1534,EnsemblGenomes-Tr:CCP44298,GOA:O08377,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR023772,UniProtKB/TrEMBL:O08377,NCBI_GP:CCP44298.1;Name=CCP44298.1;Note=Rv1534%2C (MTCY07A7A.03)%2C len: 225 aa. Probable transcriptional regulator%2C similar to YCDC_ECOLI|P75899 hypothetical transcriptional regulator from Escherichia coli (212 aa)%2C FASTA scores: opt: 166%2C E(): 9.8e-05%2C (24.2%25 identity in 219 aa overlap). Contains PS01081 Bacterial regulatory proteins%2C TetR family signature and helix turn helix motif (aa 41-62).;gbkey=CDS;inference=protein motif:PROSITE:PS01081;locus_tag=Rv1534;product=Probable transcriptional regulator;protein_id=CCP44298.1;transl_table=11
AL123456.3	EMBL	gene	1735976	1736212	.	+	.	ID=gene-Rv1535;Name=Rv1535;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1535
AL123456.3	EMBL	CDS	1735976	1736212	.	+	0	ID=cds-CCP44299.1;Parent=gene-Rv1535;Dbxref=EnsemblGenomes-Gn:Rv1535,EnsemblGenomes-Tr:CCP44299,UniProtKB/TrEMBL:O06180,NCBI_GP:CCP44299.1;Name=CCP44299.1;Note=Rv1535%2C (MTCY07A7A.04)%2C len: 78 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1535;product=Unknown protein;protein_id=CCP44299.1;transl_table=11
AL123456.3	EMBL	gene	1736519	1739644	.	+	.	ID=gene-Rv1536;Name=ileS;gbkey=Gene;gene=ileS;gene_biotype=protein_coding;locus_tag=Rv1536
AL123456.3	EMBL	CDS	1736519	1739644	.	+	0	ID=cds-CCP44300.1;Parent=gene-Rv1536;Dbxref=EnsemblGenomes-Gn:Rv1536,EnsemblGenomes-Tr:CCP44300,GOA:P9WFV3,InterPro:IPR001412,InterPro:IPR002300,InterPro:IPR002301,InterPro:IPR009008,InterPro:IPR009080,InterPro:IPR013155,InterPro:IPR014729,InterPro:IPR023586,NCBI_GP:CCP44300.1;Name=CCP44300.1;Note=Rv1536%2C (MTCY48.29c-MTCCY07A7A.05)%2C len: 1041 aa. ileS%2C Isoleucyl-tRNA synthetase %2C similar to several e.g. SYIC_YEAST P09436 isoleucyl-tRNA synthetase (1072 aa)%2CFASTA scores: opt: 1447%2C E(): 0%2C (37.8%25 identity in 1072 aa overlap)%3B contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ileS;inference=protein motif:PROSITE:PS00178;locus_tag=Rv1536;product=Isoleucyl-tRNA synthetase IleS;protein_id=CCP44300.1;transl_table=11
AL123456.3	EMBL	gene	1739856	1741247	.	+	.	ID=gene-Rv1537;Name=dinX;gbkey=Gene;gene=dinX;gene_biotype=protein_coding;gene_synonym=dinB1;locus_tag=Rv1537
AL123456.3	EMBL	CDS	1739856	1741247	.	+	0	ID=cds-CCP44301.1;Parent=gene-Rv1537;Dbxref=EnsemblGenomes-Gn:Rv1537,EnsemblGenomes-Tr:CCP44301,GOA:P9WNT3,InterPro:IPR001126,InterPro:IPR017961,InterPro:IPR017963,InterPro:IPR022880,InterPro:IPR024728,NCBI_GP:CCP44301.1;Name=CCP44301.1;Note=Rv1537%2C (MTCY48.28c%2C MT1589)%2C len: 463 aa. Probable dinX (alternate gene name: dinB1)%2C DNA polymerase IV. Similar to umuC%2C mucB%2C samb%2C and impb (UV protection and mutation) e.g. IMPB_SALTY|P18642 impb protein from Salmonella typhimurium (424 aa)%2C FASTA scores: opt: 386%2CE(): 1.7e-17%2C (27.5%25 identity in 415 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis Rv3056|dinP. Belongs to the DNA polymerase type-Y family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dinX;locus_tag=Rv1537;product=Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed));protein_id=CCP44301.1;transl_table=11
AL123456.3	EMBL	gene	1741212	1742192	.	-	.	ID=gene-Rv1538c;Name=ansA;gbkey=Gene;gene=ansA;gene_biotype=protein_coding;locus_tag=Rv1538c
AL123456.3	EMBL	CDS	1741212	1742192	.	-	0	ID=cds-CCP44302.1;Parent=gene-Rv1538c;Dbxref=EnsemblGenomes-Gn:Rv1538c,EnsemblGenomes-Tr:CCP44302,GOA:P9WPX5,InterPro:IPR006034,InterPro:IPR020827,InterPro:IPR027473,InterPro:IPR027474,InterPro:IPR027475,NCBI_GP:CCP44302.1;Name=CCP44302.1;Note=Rv1538c%2C (MTCY48.27)%2C len: 326 aa. Probable ansA%2CL-aparaginase%2C most similar to ASPG_BACLI|P30363 L-asparaginase (322 aa)%2C FASTA scores: opt: 417%2C E(): 8.8e-19%2C (30.9%25 identity in 314 aa overlap). Contains PS00917 Asparaginase / glutaminase active site signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ansA;inference=protein motif:PROSITE:PS00917;locus_tag=Rv1538c;product=Probable L-aparaginase AnsA;protein_id=CCP44302.1;transl_table=11
AL123456.3	EMBL	gene	1742244	1742852	.	+	.	ID=gene-Rv1539;Name=lspA;gbkey=Gene;gene=lspA;gene_biotype=protein_coding;locus_tag=Rv1539
AL123456.3	EMBL	CDS	1742244	1742852	.	+	0	ID=cds-CCP44303.1;Parent=gene-Rv1539;Dbxref=EnsemblGenomes-Gn:Rv1539,EnsemblGenomes-Tr:CCP44303,GOA:P9WK99,InterPro:IPR001872,NCBI_GP:CCP44303.1;Name=CCP44303.1;Note=Rv1539%2C (MTCY48.26c)%2C len: 202 aa. Probable lspA%2Clipoprotein signal peptidase (see citation below)%2C similar to several e.g. LSPA_PSEFL|P17942 (170 aa)%2C FASTA scores: opt: 299%2C E(): 2.6e-12%2C (38.3%25 identity in 167 aa overlap). Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;gbkey=CDS;gene=lspA;locus_tag=Rv1539;product=Probable lipoprotein signal peptidase LspA;protein_id=CCP44303.1;transl_table=11
AL123456.3	EMBL	gene	1742845	1743771	.	+	.	ID=gene-Rv1540;Name=Rv1540;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1540
AL123456.3	EMBL	CDS	1742845	1743771	.	+	0	ID=cds-CCP44304.1;Parent=gene-Rv1540;Dbxref=EnsemblGenomes-Gn:Rv1540,EnsemblGenomes-Tr:CCP44304,GOA:P9WHQ3,InterPro:IPR002942,InterPro:IPR006145,InterPro:IPR006224,InterPro:IPR006225,InterPro:IPR020103,NCBI_GP:CCP44304.1;Name=CCP44304.1;Note=Rv1540%2C (MTCY48.25c)%2C len: 308 aa. Member of the yabO/yceC/yfiI family of hypothetical proteins%2C similar to P44445|YFII_HAEIN hypothetical protein HI0176 from Haemophilus influenzae (324 aa)%2C FASTA scores: opt: 437%2CE(): 1.2e-22%2C (33.2%25 identity in 322 aa overlap). Equivalent to AL049478|MLCL458_13 hypothetical protein from Mycobacterium leprae (308 aa)%2C (89.3%25 identity in 307 aa overlap). Contains PS01129 hypothetical yabO/yceC/yfiI family signature.;gbkey=CDS;inference=protein motif:PROSITE:PS01129;locus_tag=Rv1540;product=Conserved hypothetical protein member of yabO/yceC/yfiI family;protein_id=CCP44304.1;transl_table=11
AL123456.3	EMBL	gene	1743778	1744371	.	-	.	ID=gene-Rv1541c;Name=lprI;gbkey=Gene;gene=lprI;gene_biotype=protein_coding;locus_tag=Rv1541c
AL123456.3	EMBL	CDS	1743778	1744371	.	-	0	ID=cds-CCP44305.1;Parent=gene-Rv1541c;Dbxref=EnsemblGenomes-Gn:Rv1541c,EnsemblGenomes-Tr:CCP44305,GOA:P9WK41,InterPro:IPR009739,InterPro:IPR018660,NCBI_GP:CCP44305.1;Name=CCP44305.1;Note=Rv1541c%2C (MTCY48.24)%2C len: 197 aa. Possible lipoprotein lprI%2C contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS0013).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprI;locus_tag=Rv1541c;product=Possible lipoprotein LprI;protein_id=CCP44305.1;transl_table=11
AL123456.3	EMBL	gene	1744426	1744836	.	-	.	ID=gene-Rv1542c;Name=glbN;gbkey=Gene;gene=glbN;gene_biotype=protein_coding;locus_tag=Rv1542c
AL123456.3	EMBL	CDS	1744426	1744836	.	-	0	ID=cds-CCP44306.1;Parent=gene-Rv1542c;Dbxref=EnsemblGenomes-Gn:Rv1542c,EnsemblGenomes-Tr:CCP44306,GOA:P9WN25,InterPro:IPR001486,InterPro:IPR009050,InterPro:IPR012292,InterPro:IPR016339,InterPro:IPR019795,PDB:1IDR,PDB:1RTE,PDB:1S56,PDB:1S61,PDB:2GKM,PDB:2GKN,PDB:2GL3,PDB:2GLN,NCBI_GP:CCP44306.1;Name=CCP44306.1;Note=Rv1542c%2C (MTCY48.23)%2C len: 136 aa. glbN%2C hemoglobin. Belongs to the protozoan/cyanobacterial globin family. Similar to myoglobins e.g. GLB_PARCA|P15160 myoglobin (hemoglobin) paramecium (116 aa)%2C FASTA scores%2C opt: 284%2CE(): 2.1e -13%2C (35.7%25 identity in 115 aa overlap). Similar to Mycobacterium tuberculosis hypothetical globin%2C Rv2470.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glbN;locus_tag=Rv1542c;product=Hemoglobin GlbN;protein_id=CCP44306.1;transl_table=11
AL123456.3	EMBL	gene	1745064	1746089	.	+	.	ID=gene-Rv1543;Name=Rv1543;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1543
AL123456.3	EMBL	CDS	1745064	1746089	.	+	0	ID=cds-CCP44307.1;Parent=gene-Rv1543;Dbxref=EnsemblGenomes-Gn:Rv1543,EnsemblGenomes-Tr:CCP44307,GOA:P9WGS1,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,NCBI_GP:CCP44307.1;Name=CCP44307.1;Note=Rv1543%2C (MTCY48.22c)%2C len: 341 aa. Possible fatty-acyl CoA reductase%2C highly similar to P94129|U77680 fatty acyl-CoA reductase ACR1 from Acinetobacter calcoaceticus (295 aa)%2C FASTA scores: opt: 899%2C E(): 0%2C(48.5%25 identity in 293 aa overlap). Also highly similar to acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty acyl-CoA reductase from Mycobacterium tuberculosis (650 aa). Also highly similar to many oxidoreductases short-chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1543;product=Possible fatty acyl-CoA reductase;protein_id=CCP44307.1;transl_table=11
AL123456.3	EMBL	gene	1746094	1746897	.	+	.	ID=gene-Rv1544;Name=Rv1544;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1544
AL123456.3	EMBL	CDS	1746094	1746897	.	+	0	ID=cds-CCP44308.1;Parent=gene-Rv1544;Dbxref=EnsemblGenomes-Gn:Rv1544,EnsemblGenomes-Tr:CCP44308,GOA:Q10782,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:Q10782,NCBI_GP:CCP44308.1;Name=CCP44308.1;Note=Rv1544%2C (MTCY48.21)%2C len: 267 aa. Possible ketoacyl reductase%2C highly similar to Z97179|MLCL383_26 putative oxidoreductase from Mycobacterium leprae (268 aa)%2C FASTA score: (43.0%25 identity in 270 aa overlap). Also highly similar to others e.g. T29125 ketoacyl reductase homolog from Streptomyces coelicolor (276 aa)%3B NP_470957.1|NC_003212 protein similar to ketoacyl reductases from Listeria innocua (253 aa)%3B HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp. strain PCC 7120 (287 aa)%2C FASTA scores: opt: 379%2C E(): 7.5e-18%2C (31.6%25 identity in 250 aa overlap)%3B etc. And highly similar to many oxidoreductases short-chain family. Also highly similar to Rv2509 from Mycobacterium tuberculosis (268 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1544;product=Possible ketoacyl reductase;protein_id=CCP44308.1;transl_table=11
AL123456.3	EMBL	gene	1746919	1747146	.	+	.	ID=gene-Rv1545;Name=Rv1545;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1545
AL123456.3	EMBL	CDS	1746919	1747146	.	+	0	ID=cds-CCP44309.1;Parent=gene-Rv1545;Dbxref=EnsemblGenomes-Gn:Rv1545,EnsemblGenomes-Tr:CCP44309,NCBI_GP:CCP44309.1;Name=CCP44309.1;Note=Rv1545%2C (MTCY48.20)%2C len: 75 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1545;product=Hypothetical protein;protein_id=CCP44309.1;transl_table=11
AL123456.3	EMBL	gene	1747195	1747626	.	+	.	ID=gene-Rv1546;Name=Rv1546;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1546
AL123456.3	EMBL	CDS	1747195	1747626	.	+	0	ID=cds-CCP44310.1;Parent=gene-Rv1546;Dbxref=EnsemblGenomes-Gn:Rv1546,EnsemblGenomes-Tr:CCP44310,GOA:P9WLU7,InterPro:IPR019587,InterPro:IPR023393,NCBI_GP:CCP44310.1;Name=CCP44310.1;Note=Rv1546%2C (MTCY48.19c)%2C len: 143 aa. Conserved protein%2C similar to O05902|Rv0910|MTCY21C12.04 Hypothetical protein from Mycobacterium tuberculosis (144 aa)%2C FASTA scores: E(): 5e-30%2C (37.3%25 identity in 142 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1546;product=Conserved protein;protein_id=CCP44310.1;transl_table=11
AL123456.3	EMBL	gene	1747694	1751248	.	+	.	ID=gene-Rv1547;Name=dnaE1;gbkey=Gene;gene=dnaE1;gene_biotype=protein_coding;locus_tag=Rv1547
AL123456.3	EMBL	CDS	1747694	1751248	.	+	0	ID=cds-CCP44311.1;Parent=gene-Rv1547;Dbxref=EnsemblGenomes-Gn:Rv1547,EnsemblGenomes-Tr:CCP44311,GOA:P9WNT7,InterPro:IPR003141,InterPro:IPR004013,InterPro:IPR004365,InterPro:IPR004805,InterPro:IPR011708,InterPro:IPR016195,InterPro:IPR029460,NCBI_GP:CCP44311.1;Name=CCP44311.1;Note=Rv1547%2C (MTCY48.18c)%2C len: 1184 aa. Probable dnaE1%2CDNA polymerase III%2C alpha chain (see citation below)%2Csimilar to many e.g. DP3A_ECOLI|P10443 dna polymerase III%2Calpha chain (1160 aa)%2C FASTA scores: opt: 1789%2C E(): 0%2C(36.5%25 identity in 1193 aa overlap). Also similar to M. tuberculosis%2C DnaE2|Rv3370c. Belongs to DNA polymerase type-C family%2C DNAE subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaE1;locus_tag=Rv1547;product=Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase);protein_id=CCP44311.1;transl_table=11
AL123456.3	EMBL	gene	1751297	1753333	.	-	.	ID=gene-Rv1548c;Name=PPE21;gbkey=Gene;gene=PPE21;gene_biotype=protein_coding;locus_tag=Rv1548c
AL123456.3	EMBL	CDS	1751297	1753333	.	-	0	ID=cds-CCP44312.1;Parent=gene-Rv1548c;Dbxref=EnsemblGenomes-Gn:Rv1548c,EnsemblGenomes-Tr:CCP44312,GOA:P9WI21,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP44312.1;Name=CCP44312.1;Note=Rv1548c%2C (MTCY48.17)%2C len: 678 aa. PPE21%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to several e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein in hsp65 3' region (517 aa)%2C FASTA scores: opt:1142%2C E(): 0%2C (40.6%25 identity in 616 aa overlap)%3B also similar to MTCY31.06c (54.9%25 identity in 381 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE21;locus_tag=Rv1548c;product=PPE family protein PPE21;protein_id=CCP44312.1;transl_table=11
AL123456.3	EMBL	gene	1753510	1754037	.	+	.	ID=gene-Rv1549;Name=fadD11.1;gbkey=Gene;gene=fadD11.1;gene_biotype=protein_coding;gene_synonym=fadD11';locus_tag=Rv1549
AL123456.3	EMBL	CDS	1753510	1754037	.	+	0	ID=cds-CCP44313.1;Parent=gene-Rv1549;Dbxref=EnsemblGenomes-Gn:Rv1549,EnsemblGenomes-Tr:CCP44313,GOA:P9WLU5,InterPro:IPR000873,NCBI_GP:CCP44313.1;Name=CCP44313.1;Note=Rv1549%2C (MTCY48.16c)%2C len: 175 aa. Possible fadD11.1%2C fatty-acid-CoA synthetase%2C similar to the N-terminus of many fatty-acid CoA synthetases e.g. NP_147860.1|NC_000854 long-chain-fatty-acid--CoA ligase from Aeropyrum pernix (651 aa)%3B P31685|4CL2_SOLTU 4-coumarate--CoA ligase 2 from Solanum tuberosum (Potato) (545 aa)%2C FASTA scores: opt: 168%2C E(): 4.4e-06%2C (30.4%25 identity in 112 aa overlap)%3B etc. Possible frameshift with respect to next ORF Rv1550|MTCY48.15c but we can find no sequence error to account for this. Note that previously known as fadD11'.;gbkey=CDS;gene=fadD11.1;locus_tag=Rv1549;product=Possible fatty-acid-CoA ligase FadD11.1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP44313.1;transl_table=11
AL123456.3	EMBL	gene	1753716	1755431	.	+	.	ID=gene-Rv1550;Name=fadD11;gbkey=Gene;gene=fadD11;gene_biotype=protein_coding;locus_tag=Rv1550
AL123456.3	EMBL	CDS	1753716	1755431	.	+	0	ID=cds-CCP44314.1;Parent=gene-Rv1550;Dbxref=EnsemblGenomes-Gn:Rv1550,EnsemblGenomes-Tr:CCP44314,GOA:P9WQ53,InterPro:IPR000873,InterPro:IPR020845,NCBI_GP:CCP44314.1;Name=CCP44314.1;Note=Rv1550%2C (MTCY48.15c)%2C len: 571 aa. Probable fadD11%2Cfatty-acid-CoA synthetase%2C similar%2C except in N-terminus%2Cto many e.g. SC6A5.39|T35430 probable long-chain-fatty-acid--CoA ligase from Streptomyces coelicolor (612 aa)%3B NP_301672.1|NC_002677 putative long-chain-fatty-acid-CoA ligase from Mycobacterium leprae (600 aa)%3B P44446|LCFH_HAEIN putative long-chain-fatty-acid-CoA ligase from Haemophilus influenzae (607 aa)%2C FASTA scores: opt: 762%2C E(): 2.3e-38%2C(34.4%25 identity in 436 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family. Possible frameshift with respect to previous ORF Rv1549|MTCY48.16c but we can find no sequence error to account for this.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD11;inference=protein motif:PROSITE:PS00455;locus_tag=Rv1550;product=Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP44314.1;transl_table=11
AL123456.3	EMBL	gene	1755445	1757310	.	+	.	ID=gene-Rv1551;Name=plsB1;gbkey=Gene;gene=plsB1;gene_biotype=protein_coding;locus_tag=Rv1551
AL123456.3	EMBL	CDS	1755445	1757310	.	+	0	ID=cds-CCP44315.1;Parent=gene-Rv1551;Dbxref=EnsemblGenomes-Gn:Rv1551,EnsemblGenomes-Tr:CCP44315,GOA:P9WI59,InterPro:IPR002123,InterPro:IPR022284,InterPro:IPR028354,NCBI_GP:CCP44315.1;Name=CCP44315.1;Note=Rv1551%2C (MT1601%2C MTCY48.14c)%2C len: 621 aa. Possible plsB1%2C acyltransferase%2C similar to PLSB_HAEIN|P44857 glycerol-3-phosphate acyltransferase from Haemophilus influenzae (810 aa)%2C FASTA scores: opt: 434%2C E(): 6.2e-22%2C(27.6%25 identity in 395 aa overlap). Also similar to Rv2482c|plsB2 Probable glycerol-3-phosphate acyltransferase from Mycobacterium tuberculosis (789 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=plsB1;locus_tag=Rv1551;product=Possible acyltransferase PlsB1;protein_id=CCP44315.1;transl_table=11
AL123456.3	EMBL	gene	1757681	1759432	.	+	.	ID=gene-Rv1552;Name=frdA;gbkey=Gene;gene=frdA;gene_biotype=protein_coding;locus_tag=Rv1552
AL123456.3	EMBL	CDS	1757681	1759432	.	+	0	ID=cds-CCP44316.1;Parent=gene-Rv1552;Dbxref=EnsemblGenomes-Gn:Rv1552,EnsemblGenomes-Tr:CCP44316,GOA:P9WN91,InterPro:IPR003952,InterPro:IPR003953,InterPro:IPR005884,InterPro:IPR013027,InterPro:IPR014006,InterPro:IPR015939,InterPro:IPR027477,NCBI_GP:CCP44316.1;Name=CCP44316.1;Note=Rv1552%2C (MTCY48.13c)%2C len: 583 aa. Probable frdA%2Cfumarate reductase%2C flavoprotein subunit%2C highly similar to others e.g. P00363|FRDA_ECOLI fumarate reductase flavoprotein subunit from Escherichia coli strain K12 (601 aa)%2C FASTA scores: opt: 2102%2C E(): 0%2C (54.7%25 identity in 585 aa overlap)%3B NP_232284.1|NC_002505 fumarate reductase%2Cflavoprotein subunit from Vibrio cholerae (602 aa)%3B frdA|NP_438995.1|NC_000907 fumarate reductase%2C flavoprotein subunit from Haemophilus influenzae (599 aa)%3B etc. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. Note that fumarate reductase forms part of an enzyme complex containing four subunits: a flavoprotein (Rv1552|frdA)%2C an iron-sulfur (Rv1553|frdB)%2Cand two hydrophobic anchor proteins (Rv1554|frdC and Rv1555|frdD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=frdA;inference=protein motif:PROSITE:PS00504;locus_tag=Rv1552;product=Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP44316.1;transl_table=11
AL123456.3	EMBL	gene	1759435	1760178	.	+	.	ID=gene-Rv1553;Name=frdB;gbkey=Gene;gene=frdB;gene_biotype=protein_coding;locus_tag=Rv1553
AL123456.3	EMBL	CDS	1759435	1760178	.	+	0	ID=cds-CCP44317.1;Parent=gene-Rv1553;Dbxref=EnsemblGenomes-Gn:Rv1553,EnsemblGenomes-Tr:CCP44317,GOA:P9WN89,InterPro:IPR001041,InterPro:IPR001450,InterPro:IPR004489,InterPro:IPR009051,InterPro:IPR012675,InterPro:IPR017896,InterPro:IPR017900,InterPro:IPR025192,NCBI_GP:CCP44317.1;Name=CCP44317.1;Note=Rv1553%2C (MTCY48.12c)%2C len: 247 aa. Probable frdB%2Cfumarate reductase%2C iron-sulfur subunit%2C highly similar to others e.g. P00364|FRDB_ECOLI fumarate reductase iron-sulfur protein from Escherichia coli strain K12 (243 aa)%2C FASTA scores: opt: 846%2C E(): 0%2C (50.0%25 identity in 242 aa overlap)%3B P20921|FRDB_PROVU fumarate reductase iron-sulfur protein from Proteus vulgaris (245 aa)%3B G64097 fumarate reductase iron-sulfur protein from Haemophilus influenzae (276 aa)%3B etc. Contains PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature. Note that fumarate reductase forms part of an enzyme complex containing four subunits: a flavoprotein (Rv1552|frdA)%2C an iron-sulfur (Rv1553|frdB)%2C and two hydrophobic anchor proteins (Rv1554|frdC and Rv1555|frdD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=frdB;inference=protein motif:PROSITE:PS00198;locus_tag=Rv1553;product=Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP44317.1;transl_table=11
AL123456.3	EMBL	gene	1760175	1760555	.	+	.	ID=gene-Rv1554;Name=frdC;gbkey=Gene;gene=frdC;gene_biotype=protein_coding;locus_tag=Rv1554
AL123456.3	EMBL	CDS	1760175	1760555	.	+	0	ID=cds-CCP44318.1;Parent=gene-Rv1554;Dbxref=EnsemblGenomes-Gn:Rv1554,EnsemblGenomes-Tr:CCP44318,GOA:P9WNB7,InterPro:IPR003510,NCBI_GP:CCP44318.1;Name=CCP44318.1;Note=Rv1554%2C (MTCY48.11c)%2C len: 126 aa. Probable frdC%2Cfumarate reductase%2C membrane-anchor subunit%2C highly similar to others e.g. P03805|FRDC_ECOLI fumarate reductase 15 kDa hydrophobic protein from Escherichia coli strain K12 (131 aa)%2C FASTA scores%2C opt: 268%2C E(): 3.9e-10%2C (31.1%25 identity in 122 aa overlap)%3B NP_458780.1|NC_003198 fumarate reductase complex subunit C%3B membrane anchor polypeptide from Salmonella enterica subsp. enterica serovar Typhi (131 aa)%3B P20923|FRDC_PROVU fumarate reductase 15 kDa hydrophobic protein from Proteus vulgaris (131 aa)%3B etc. Note that fumarate reductase forms part of an enzyme complex containing four subunits: a flavoprotein (Rv1552|frdA)%2C an iron-sulfur (Rv1553|frdB)%2C and two hydrophobic anchor proteins (Rv1554|frdC and Rv1555|frdD).;gbkey=CDS;gene=frdC;locus_tag=Rv1554;product=Probable fumarate reductase [membrane anchor subunit] FrdC (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP44318.1;transl_table=11
AL123456.3	EMBL	gene	1760552	1760929	.	+	.	ID=gene-Rv1555;Name=frdD;gbkey=Gene;gene=frdD;gene_biotype=protein_coding;locus_tag=Rv1555
AL123456.3	EMBL	CDS	1760552	1760929	.	+	0	ID=cds-CCP44319.1;Parent=gene-Rv1555;Dbxref=EnsemblGenomes-Gn:Rv1555,EnsemblGenomes-Tr:CCP44319,GOA:P9WNB5,InterPro:IPR003418,NCBI_GP:CCP44319.1;Name=CCP44319.1;Note=Rv1555%2C (MTCY48.10c)%2C len: 125 aa. Probable frdD%2Cfumarate reductase%2C membrane-anchor subunit%2C similar to others e.g. P03806|FRDD_ECOLI fumarate reductase 13 kDa hydrophobic protein from Escherichia coli strain K12 (119 aa)%2C FASTA scores: opt: 212%2C E(): 4.4e-08%2C (36.8%25 identity in 106 aa overlap)%3B etc. Note that fumarate reductase forms part of an enzyme complex containing four subunits: a flavoprotein (Rv1552|frdA)%2C an iron-sulfur (Rv1553|frdB)%2Cand two hydrophobic anchor proteins (Rv1554|frdC and Rv1555|frdD).;gbkey=CDS;gene=frdD;locus_tag=Rv1555;product=Probable fumarate reductase [membrane anchor subunit] FrdD (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP44319.1;transl_table=11
AL123456.3	EMBL	gene	1760997	1761605	.	+	.	ID=gene-Rv1556;Name=Rv1556;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1556
AL123456.3	EMBL	CDS	1760997	1761605	.	+	0	ID=cds-CCP44320.1;Parent=gene-Rv1556;Dbxref=EnsemblGenomes-Gn:Rv1556,EnsemblGenomes-Tr:CCP44320,GOA:P9WMD1,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR023772,NCBI_GP:CCP44320.1;Name=CCP44320.1;Note=Rv1556%2C (MTCY48.09c)%2C len: 202 aa. Possible regulatory protein%2C similar to X86780|SHGCPIR2|g987088 orfY%2C regulator of antibiotic transport complexes from Streptomyces hygroscopicus (204 aa)%2C FASTA score: opt: 251%2CE(): 1.7e-10%2C (33.8%25 identity in 201 aa overlap) and others.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1556;product=Possible regulatory protein;protein_id=CCP44320.1;transl_table=11
AL123456.3	EMBL	gene	1761744	1762937	.	+	.	ID=gene-Rv1557;Name=mmpL6;gbkey=Gene;gene=mmpL6;gene_biotype=protein_coding;locus_tag=Rv1557
AL123456.3	EMBL	CDS	1761744	1762937	.	+	0	ID=cds-CCP44321.1;Parent=gene-Rv1557;Dbxref=EnsemblGenomes-Gn:Rv1557,EnsemblGenomes-Tr:CCP44321,GOA:P9WJU9,InterPro:IPR004869,NCBI_GP:CCP44321.1;Name=CCP44321.1;Note=Rv1557%2C (MTCY48.08c)%2C len: 397 aa. Probable mmpL6%2Cconserved transmembrane transport protein (see citations below). Member of RND superfamily%2C with strong similarity to C-terminal part of members of large Mycobacterial membrane protein family belonging to RND superfamily including: mmpL1%2C mmpL2%2C mmpL3%2C etc. Probably truncated (see Brosch et al.%2C 2002). Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL6;locus_tag=Rv1557;product=Probable conserved transmembrane transport protein MmpL6;protein_id=CCP44321.1;transl_table=11
AL123456.3	EMBL	gene	1762947	1763393	.	+	.	ID=gene-Rv1558;Name=Rv1558;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1558
AL123456.3	EMBL	CDS	1762947	1763393	.	+	0	ID=cds-CCP44322.1;Parent=gene-Rv1558;Dbxref=EnsemblGenomes-Gn:Rv1558,EnsemblGenomes-Tr:CCP44322,GOA:P9WP11,InterPro:IPR004378,InterPro:IPR012349,NCBI_GP:CCP44322.1;Name=CCP44322.1;Note=Rv1558%2C (MTCY48.07c)%2C len: 148 aa. Conserved protein%2C similar to other Mycobacterial tuberculosis proteins e.g. P71854|MTCY03C7.09c|Rv3547 (151 aa)%2C FASTA scores opt: 330%2C E(): 9.1e-17%2C (39.7%25 identity in 151 aa overlap)%3B also Q11057|Rv1261c (149 aa)%2C and O53328|Rv3178 (119 aa). Similar also to AF072709|AF072709_5 Hypothetical protein with a new amplifiable element AUD4 from Streptomyces lividans (149 aa)%2C FASTA scores: opt: 695%2CE(): 0%2C (69.1%25 identity in 149 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1558;product=Conserved protein;protein_id=CCP44322.1;transl_table=11
AL123456.3	EMBL	gene	1763428	1764717	.	+	.	ID=gene-Rv1559;Name=ilvA;gbkey=Gene;gene=ilvA;gene_biotype=protein_coding;locus_tag=Rv1559
AL123456.3	EMBL	CDS	1763428	1764717	.	+	0	ID=cds-CCP44323.1;Parent=gene-Rv1559;Dbxref=EnsemblGenomes-Gn:Rv1559,EnsemblGenomes-Tr:CCP44323,GOA:P9WG95,InterPro:IPR000634,InterPro:IPR001721,InterPro:IPR001926,InterPro:IPR011820,NCBI_GP:CCP44323.1;Name=CCP44323.1;Note=Rv1559%2C (MTCY48.06c)%2C len: 429 aa. Probable ilvA%2Cthreonine dehydratase%2C biosynthetic protein%2C similar to several e.g. THD1_CORGL|Q04513 threonine dehydratase biosynthetic (436 aa)%2C FASTA scores: opt: 1694%2C E(): 0%2C(61.9%25 identity in 415 aa overlap). Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvA;inference=protein motif:PROSITE:PS00165;locus_tag=Rv1559;product=Probable threonine dehydratase IlvA;protein_id=CCP44323.1;transl_table=11
AL123456.3	EMBL	gene	1764755	1764973	.	+	.	ID=gene-Rv1560;Name=vapB11;gbkey=Gene;gene=vapB11;gene_biotype=protein_coding;locus_tag=Rv1560
AL123456.3	EMBL	CDS	1764755	1764973	.	+	0	ID=cds-CCP44324.1;Parent=gene-Rv1560;Dbxref=EnsemblGenomes-Gn:Rv1560,EnsemblGenomes-Tr:CCP44324,GOA:P9WLU3,InterPro:IPR019239,NCBI_GP:CCP44324.1;Name=CCP44324.1;Note=Rv1560%2C (MTCY48.05c)%2C len: 72 aa. Possible vapB11%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1561 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Part of a Mycobacterial tuberculosis family of proteins e.g. Q10848|Rv2009|MTCY39.08c (80 aa)%2C FASTA score: (54.4%25 identity in 68 aa overlap)%3B Q10799|Rv2871|MTCY274.02 (85 aa)%3B O50456|Rv1241|MTV006.13 (86 aa)%2CO06243|Rv2132|MTCY270.36C (76 aa)%3B etc.;gbkey=CDS;gene=vapB11;locus_tag=Rv1560;product=Possible antitoxin VapB11;protein_id=CCP44324.1;transl_table=11
AL123456.3	EMBL	gene	1764979	1765383	.	+	.	ID=gene-Rv1561;Name=vapC11;gbkey=Gene;gene=vapC11;gene_biotype=protein_coding;locus_tag=Rv1561
AL123456.3	EMBL	CDS	1764979	1765383	.	+	0	ID=cds-CCP44325.1;Parent=gene-Rv1561;Dbxref=EnsemblGenomes-Gn:Rv1561,EnsemblGenomes-Tr:CCP44325,GOA:P9WFA5,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44325.1;Name=CCP44325.1;Note=Rv1561%2C (MTCY48.04c)%2C len: 134 aa. Possible vapC11%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1560%2Ccontains PIN domain%2C (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others from Mycobacterium tuberculosis e.g. Q10847|Rv2010|MTCY39.07c (132 aa)%2C FASTA scores: (37.0%25 identity in 127 aa overlap)%3B and O06566|Rv1114|MTCY22G8.03 (124 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC11;locus_tag=Rv1561;product=Possible toxin VapC11;protein_id=CCP44325.1;transl_table=11
AL123456.3	EMBL	gene	1765400	1767142	.	-	.	ID=gene-Rv1562c;Name=treZ;gbkey=Gene;gene=treZ;gene_biotype=protein_coding;gene_synonym=glgZ;locus_tag=Rv1562c
AL123456.3	EMBL	CDS	1765400	1767142	.	-	0	ID=cds-CCP44326.1;Parent=gene-Rv1562c;Dbxref=EnsemblGenomes-Gn:Rv1562c,EnsemblGenomes-Tr:CCP44326,GOA:P9WQ23,InterPro:IPR006047,InterPro:IPR012768,InterPro:IPR013781,InterPro:IPR013783,InterPro:IPR014756,InterPro:IPR015902,InterPro:IPR017853,InterPro:IPR022567,NCBI_GP:CCP44326.1;Name=CCP44326.1;Note=Rv1562c%2C (MTCY48.03)%2C len: 580 aa. TreZ (previously called glgZ)%2C Maltooligosyltrehalose trehalohydrolase%2Cconfirmed biochemically (see citation below). Similar to Q44316|D63343 TREZ maltooligosyl trehalose trehalohydrolase from arthrobacter SP (598 aa)%2C FASTA scores: opt: 2071%2CE(): 0%2C (52.2%25 identity in 582 aa overlap)%3B also similar to 1%2C4-alpha-glucan branching enzymes e.g. GLGB_BACST|P30538 (639 aa)%2C FASTA scores: opt: 313%2C E(): 3.8e-13%2C (27.5%25 identity in 462 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv1326c|glgB%2C and Rv1563c treY (previously glgY).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=treZ;locus_tag=Rv1562c;product=Maltooligosyltrehalose trehalohydrolase TreZ;protein_id=CCP44326.1;transl_table=11
AL123456.3	EMBL	gene	1767135	1769432	.	-	.	ID=gene-Rv1563c;Name=treY;gbkey=Gene;gene=treY;gene_biotype=protein_coding;gene_synonym=glgY;locus_tag=Rv1563c
AL123456.3	EMBL	CDS	1767135	1769432	.	-	0	ID=cds-CCP44327.1;Parent=gene-Rv1563c;Dbxref=EnsemblGenomes-Gn:Rv1563c,EnsemblGenomes-Tr:CCP44327,GOA:P9WQ21,InterPro:IPR006047,InterPro:IPR012767,InterPro:IPR013781,InterPro:IPR013797,InterPro:IPR015902,InterPro:IPR017853,NCBI_GP:CCP44327.1;Name=CCP44327.1;Note=Rv1563c%2C (MTCY48.02)%2C len: 765 aa. TreY (previously called glgY)%2C maltooligosyl trehalose synthase%2C confirmed biochemically (see citation below). Strong similarity to Q44315|63343 trey maltooligosyl trehalose synthase from arthrobacter SP (775 aa)%2C fasta scores: opt: 1953%2C E(): 0%3B (46.0%25 identity in 789 aa overlap). Some similarity to alpha-amylases and to MTCY48.03 (30.2%25 identity in 215 aa overlap). May catalyse conversion of maltodextrins to maltooligosyl trehaloses. Also similar to Mycobacterium tuberculosis glgB (Rv1326c)%2C treZ (Rv1562c).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=treY;locus_tag=Rv1563c;product=Maltooligosyltrehalose synthase TreY;protein_id=CCP44327.1;transl_table=11
AL123456.3	EMBL	gene	1769436	1771601	.	-	.	ID=gene-Rv1564c;Name=treX;gbkey=Gene;gene=treX;gene_biotype=protein_coding;gene_synonym=glgX;locus_tag=Rv1564c
AL123456.3	EMBL	CDS	1769436	1771601	.	-	0	ID=cds-CCP44328.1;Parent=gene-Rv1564c;Dbxref=EnsemblGenomes-Gn:Rv1564c,EnsemblGenomes-Tr:CCP44328,GOA:P9WQ25,InterPro:IPR004193,InterPro:IPR006047,InterPro:IPR011837,InterPro:IPR013780,InterPro:IPR013781,InterPro:IPR013783,InterPro:IPR014756,InterPro:IPR015902,InterPro:IPR017853,NCBI_GP:CCP44328.1;Name=CCP44328.1;Note=Rv1564c%2C (MTCY48.01)%2C len: 721 aa. Probable treX (previously called glgX)%2C Maltooligosyltrehalose synthase. Strong similarity to D83245|g1890053 treX%2C glycogen debranching enzyme (glgX) from Sulfolobus acidocaldarius (713 aa)%2C FASTA score: opt: 2396%2C E(): 0%2C (48.4%25 identity in 709 aa overlap)%3B similar to GLGX_HAEIN|P45178 glycogen operon protein glgx (659 aa)%2C FASTA scores: opt: 1512%2C E(): 0%2C (42.3%25 identity in 645 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=treX;locus_tag=Rv1564c;product=Probable maltooligosyltrehalose synthase TreX;protein_id=CCP44328.1;transl_table=11
AL123456.3	EMBL	gene	1771640	1773829	.	-	.	ID=gene-Rv1565c;Name=Rv1565c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1565c
AL123456.3	EMBL	CDS	1771640	1773829	.	-	0	ID=cds-CCP44329.1;Parent=gene-Rv1565c;Dbxref=EnsemblGenomes-Gn:Rv1565c,EnsemblGenomes-Tr:CCP44329,GOA:O06625,InterPro:IPR002656,UniProtKB/TrEMBL:O06625,NCBI_GP:CCP44329.1;Name=CCP44329.1;Note=Rv1565c%2C (MTCY336.38)%2C len: 729 aa. Conserved hypothetical membrane protein%2C some similarity to O05402 hypothetical 72.2 kDa protein from Bacillus subtilis (634 aa)%2C FASTA results: opt: 384%2C E(): 4.8e-17%2C (29.1%25 identity in 378 aa overlap)%3B and to Y392_HAEIN|P43993 hypothetical protein hi0392 from H. influenzae (245 aa)%2C FASTA results: opt: 265%2C E(): 5.5e-10%2C (28.3%25 identity in 247 aa overlap). C-terminal half equivalent to AL049478|MLCL458_19 (274 aa) (78.5%25 identity in 274 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv0111%2CRv0228%2C Rv1254%2C Rv0517. N-terminal half hydrophobic.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1565c;product=Conserved hypothetical membrane protein;protein_id=CCP44329.1;transl_table=11
AL123456.3	EMBL	gene	1773928	1774620	.	-	.	ID=gene-Rv1566c;Name=Rv1566c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1566c
AL123456.3	EMBL	CDS	1773928	1774620	.	-	0	ID=cds-CCP44330.1;Parent=gene-Rv1566c;Dbxref=EnsemblGenomes-Gn:Rv1566c,EnsemblGenomes-Tr:CCP44330,GOA:O06624,InterPro:IPR000064,PDB:4JXB,PDB:4LJ1,UniProtKB/TrEMBL:O06624,NCBI_GP:CCP44330.1;Name=CCP44330.1;Note=Rv1566c%2C (MTCY336.37)%2C len: 230 aa. Possible inv protein%2C probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 aa)%2C FASTA scores: opt: 957%2C E(): 0%2C (70.0%25 identity in 207 aa overlap)%3B also to putative invasins 1%2C2 (O07390%2C O07391) from Mycobacterium avium. Slightly similar to C-terminus of P60_LISMO|P21171 Listeria invasion-associated protein p60 precursor. Also similar to Mycobacterium tuberculosis p60 homologues Rv1477%2C Rv1478%2CRv0024%2C Rv2190c. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1566c;product=Possible Inv protein;protein_id=CCP44330.1;transl_table=11
AL123456.3	EMBL	gene	1774860	1775144	.	-	.	ID=gene-Rv1567c;Name=Rv1567c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1567c
AL123456.3	EMBL	CDS	1774860	1775144	.	-	0	ID=cds-CCP44331.1;Parent=gene-Rv1567c;Dbxref=EnsemblGenomes-Gn:Rv1567c,EnsemblGenomes-Tr:CCP44331,GOA:O06623,UniProtKB/TrEMBL:O06623,NCBI_GP:CCP44331.1;Name=CCP44331.1;Note=Rv1567c%2C (MTCY336.36)%2C len: 94 aa. Probable membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1567c;product=Probable hypothetical membrane protein;protein_id=CCP44331.1;transl_table=11
AL123456.3	EMBL	gene	1775392	1776705	.	+	.	ID=gene-Rv1568;Name=bioA;gbkey=Gene;gene=bioA;gene_biotype=protein_coding;locus_tag=Rv1568
AL123456.3	EMBL	CDS	1775392	1776705	.	+	0	ID=cds-CCP44332.1;Parent=gene-Rv1568;Dbxref=EnsemblGenomes-Gn:Rv1568,EnsemblGenomes-Tr:CCP44332,GOA:P9WQ81,InterPro:IPR005814,InterPro:IPR005815,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,PDB:3BV0,PDB:3LV2,PDB:3TFT,PDB:3TFU,NCBI_GP:CCP44332.1;Name=CCP44332.1;Note=Rv1568%2C (MTCY336.35c)%2C len: 437 aa. bioA%2Cadenosylmethionine-8-amino-7-oxononanoate aminotransferase %2C equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below). Highly similar to BIOA_MYCLE|P4548 from Mycobacterium leprae (436 aa)%2C FASTA results: opt: 2534%2C E(): 0%2C (85.1%25 identity in 436 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. MTCY227.12c (449 aa)%2C FASTA score: E(): 3.5e-16%2C (29.5%25 identity in 421 aa overlap). Contains aminotransferases class-III pyridoxal-phosphate attachment site (PS00600). Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bioA;inference=protein motif:PROSITE:PS00600;locus_tag=Rv1568;product=Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA;protein_id=CCP44332.1;transl_table=11
AL123456.3	EMBL	gene	1776702	1777862	.	+	.	ID=gene-Rv1569;Name=bioF1;gbkey=Gene;gene=bioF1;gene_biotype=protein_coding;locus_tag=Rv1569
AL123456.3	EMBL	CDS	1776702	1777862	.	+	0	ID=cds-CCP44333.1;Parent=gene-Rv1569;Dbxref=EnsemblGenomes-Gn:Rv1569,EnsemblGenomes-Tr:CCP44333,GOA:P9WQ87,InterPro:IPR001917,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP44333.1;Name=CCP44333.1;Note=Rv1569%2C (MTCY336.34c)%2C len: 386 aa. Probable bioF1%2C8-amino-7-oxononanoate synthase%2C highly similar to BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa)%2C FASTA results: opt: 1971%2C E(): 0%2C (80.1%25 identity in 381 aa overlap). Also similar to BIOF2|Rv0032|MTCY10H4.32 possible 8-amino-7-oxononanoate synthase from Mycobacterium tuberculosis (771 aa)%2C FASTA score: E(): 5.5e-29%2C (37.4%25 identity in 393 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). Belongs to class-II of pyridoxal-phosphate-dependent aminotransferases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bioF1;inference=protein motif:PROSITE:PS00599;locus_tag=Rv1569;product=Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase);protein_id=CCP44333.1;transl_table=11
AL123456.3	EMBL	gene	1777859	1778539	.	+	.	ID=gene-Rv1570;Name=bioD;gbkey=Gene;gene=bioD;gene_biotype=protein_coding;locus_tag=Rv1570
AL123456.3	EMBL	CDS	1777859	1778539	.	+	0	ID=cds-CCP44334.1;Parent=gene-Rv1570;Dbxref=EnsemblGenomes-Gn:Rv1570,EnsemblGenomes-Tr:CCP44334,GOA:P9WPQ5,InterPro:IPR004472,InterPro:IPR027417,PDB:3FGN,PDB:3FMF,PDB:3FMI,PDB:3FPA,NCBI_GP:CCP44334.1;Name=CCP44334.1;Note=Rv1570%2C (MTCY336.33c)%2C len: 226 aa. bioD%2Cdethiobiotin synthetase. Similar to many e.g. BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa)%2C FASTA results: opt: 1059%2C E(): 0%2C (74.8%25 identity in 222 aa overlap). Belongs to the dethiobiotin synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bioD;locus_tag=Rv1570;product=Dethiobiotin synthetase BioD;protein_id=CCP44334.1;transl_table=11
AL123456.3	EMBL	gene	1778539	1779048	.	+	.	ID=gene-Rv1571;Name=Rv1571;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1571
AL123456.3	EMBL	CDS	1778539	1779048	.	+	0	ID=cds-CCP44335.1;Parent=gene-Rv1571;Dbxref=EnsemblGenomes-Gn:Rv1571,EnsemblGenomes-Tr:CCP44335,GOA:O06619,InterPro:IPR009097,UniProtKB/TrEMBL:O06619,NCBI_GP:CCP44335.1;Name=CCP44335.1;Note=Rv1571%2C (MTCY336.32c)%2C len: 169 aa. Conserved protein%2C similar at N-terminal region to Q49625|LEPB1170_C3_227 hypothetical protein from Mycobacterium leprae (104 aa)%2C FASTA results: opt: 473%2CE(): 3.9e-24%2C (74.5%25 identity in 102 aa overlap). Identical to O06619|AF041819|AF041819_6 Mycobacterium bovis BCG (169 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1571;product=Conserved protein;protein_id=CCP44335.1;transl_table=11
AL123456.3	EMBL	gene	1779194	1779298	.	-	.	ID=gene-Rv1572c;Name=Rv1572c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1572c
AL123456.3	EMBL	CDS	1779194	1779298	.	-	0	ID=cds-CCP44336.1;Parent=gene-Rv1572c;Dbxref=EnsemblGenomes-Gn:Rv1572c,EnsemblGenomes-Tr:CCP44336,UniProtKB/TrEMBL:O06618,NCBI_GP:CCP44336.1;Name=CCP44336.1;Note=Rv1572c%2C (MTCY336.31B)%2C len: 34 aa. Partial ORF%2Cpart of REP13E12 repeat element%3B 3' end of Rv1587c (MTCY336.17) after phage-like element (see citation below). Similar to C-terminal ends of other REP13E12 repeat elements e.g. Rv1148%2C Rv1945%2C Rv3467%2C etc. Length extended since first submission (+7 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1572c;product=Conserved hypothetical protein;protein_id=CCP44336.1;transl_table=11
AL123456.3	EMBL	repeat_region	1779266	1779277	.	-	.	ID=id-Rv1572c;Note=12 bp direct repeat 1%2C ccacggccaacc%2C flanking phage-like element%2C second site at 1788514..1788525. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region;locus_tag=Rv1572c
AL123456.3	EMBL	gene	1779314	1779724	.	+	.	ID=gene-Rv1573;Name=Rv1573;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1573
AL123456.3	EMBL	CDS	1779314	1779724	.	+	0	ID=cds-CCP44337.1;Parent=gene-Rv1573;Dbxref=EnsemblGenomes-Gn:Rv1573,EnsemblGenomes-Tr:CCP44337,UniProtKB/TrEMBL:O06617,NCBI_GP:CCP44337.1;Name=CCP44337.1;Note=Rv1573%2C (MTCY336.31c)%2C len: 136 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1573;product=Probable PhiRv1 phage protein;protein_id=CCP44337.1;transl_table=11
AL123456.3	EMBL	gene	1779930	1780241	.	+	.	ID=gene-Rv1574;Name=Rv1574;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1574
AL123456.3	EMBL	CDS	1779930	1780241	.	+	0	ID=cds-CCP44338.1;Parent=gene-Rv1574;Dbxref=EnsemblGenomes-Gn:Rv1574,EnsemblGenomes-Tr:CCP44338,UniProtKB/TrEMBL:L0TA08,NCBI_GP:CCP44338.1;Name=CCP44338.1;Note=Rv1574%2C (MTCY336.30)%2C len: 103 aa. Probable phiRV1 phage related protein (see citation below)%3B some similarity to N-terminus of Rv1575|MTCY441.17 Probable phiRV1 phage protein (166 aa)%2C E(): 1.5e-06%3B and Rv2647|MTCY336.29c Probable phiRV2 phage protein%2C E(): 3.5e-05. Helix turn helix motif present at aa 14-35 (+3.61 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1574;product=Probable PhiRv1 phage related protein;protein_id=CCP44338.1;transl_table=11
AL123456.3	EMBL	repeat_region	1779959	1780047	.	-	.	ID=id-AL123456.3:1779959..1780047;Note=89 bp direct repeat 2%2C first copy at 1780485..1780573%2C GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCCGGCGGAGATGCCGAGGGC TG CGCCGATAGCAGTGTCTGTTTTCGTCGAA. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	1780199	1780699	.	+	.	ID=gene-Rv1575;Name=Rv1575;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1575
AL123456.3	EMBL	CDS	1780199	1780699	.	+	0	ID=cds-CCP44339.1;Parent=gene-Rv1575;Dbxref=EnsemblGenomes-Gn:Rv1575,EnsemblGenomes-Tr:CCP44339,UniProtKB/TrEMBL:L0T9U5,NCBI_GP:CCP44339.1;Name=CCP44339.1;Note=Rv1575%2C (MTCY336.29c)%2C len: 166 aa. Probable phiRV1 phage protein (see citation below)%2C showing similarity in N-terminal part to Rv1574|MTCY336.30c Probable phiRV1 phage protein (103 aa)%2C FASTA score: opt: 375%2C E(): 3.8e-16%2C(60.2%25 identity in 103 aa overlap)%3B and Rv2647 Probable phiRV2 phage protein. Start changed since first submission (+49 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1575;product=Probable PhiRv1 phage protein;protein_id=CCP44339.1;transl_table=11
AL123456.3	EMBL	repeat_region	1780485	1780573	.	-	.	ID=id-AL123456.3:1780485..1780573;Note=89 bp direct repeat 1%2C second copy at 1779959..1780047%2C GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCCGGCGGAGATGCCGAGGGC TG CGCCGATAGCAGTGTCTGTTTTCGTCGAA. Many repeats%2C both direct and inverted%2C in this region. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	1780643	1782064	.	-	.	ID=gene-Rv1576c;Name=Rv1576c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1576c
AL123456.3	EMBL	CDS	1780643	1782064	.	-	0	ID=cds-CCP44340.1;Parent=gene-Rv1576c;Dbxref=EnsemblGenomes-Gn:Rv1576c,EnsemblGenomes-Tr:CCP44340,GOA:O06614,InterPro:IPR006444,InterPro:IPR024455,UniProtKB/TrEMBL:O06614,NCBI_GP:CCP44340.1;Name=CCP44340.1;Note=Rv1576c%2C (MTCY336.28)%2C len: 473 aa. Probable phiRV1 phage protein (capsid subunit) (see citation below). Highly similar to hypothetical Mycobacterium tuberculosis protein Rv2650c|MTCY441.19 phiRV2 phage related protein%2C FASTA scores: opt: 2782%2C E(): 0%2C (89.1%25 identity in 468 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1576c;product=Probable PhiRv1 phage protein;protein_id=CCP44340.1;transl_table=11
AL123456.3	EMBL	gene	1782072	1782584	.	-	.	ID=gene-Rv1577c;Name=Rv1577c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1577c
AL123456.3	EMBL	CDS	1782072	1782584	.	-	0	ID=cds-CCP44341.1;Parent=gene-Rv1577c;Dbxref=EnsemblGenomes-Gn:Rv1577c,EnsemblGenomes-Tr:CCP44341,InterPro:IPR006433,UniProtKB/TrEMBL:O06613,NCBI_GP:CCP44341.1;Name=CCP44341.1;Note=Rv1577c%2C (MTCY336.27)%2C len: 170 aa. Probable phiRv1 phage protein (prohead protease) (see citation below). Highly similar to hypothetical protein Rv2651c|MTCY441.20c phiRV2 prohead protease%2C FASTA scores: E(): 0%2C (89.3%25 identity in 169 aa overlap). Some similarity to VP4_BPHK7|P49860 putative bacteriophage HK97 prohead protease (gp4) (225 aa)%2C FASTA results: opt: 176%2C E(): 1.3e-05%2C (27.3%25 identity in 165 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1577c;product=Probable PhiRv1 phage protein;protein_id=CCP44341.1;transl_table=11
AL123456.3	EMBL	gene	1782758	1783228	.	-	.	ID=gene-Rv1578c;Name=Rv1578c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1578c
AL123456.3	EMBL	CDS	1782758	1783228	.	-	0	ID=cds-CCP44342.1;Parent=gene-Rv1578c;Dbxref=EnsemblGenomes-Gn:Rv1578c,EnsemblGenomes-Tr:CCP44342,InterPro:IPR006448,UniProtKB/TrEMBL:O06612,NCBI_GP:CCP44342.1;Name=CCP44342.1;Note=Rv1578c%2C (MTCY336.26)%2C len: 156 aa. Probable phiRv1 phage protein (terminase) (see citation below)%2C highly similar to Rv2652c|MTCY441.21c phiRV2 phage protein from Mycobacterium tuberculosis%2C FASTA scores: E(): 4.8e-22%2C(48.1%25 identity in 156 aa overlap). Also similar to X65555|ARP3COS_1 hypothetical protein (cos site) -actinophage RP3 (210 aa)%2C FASTA scores: opt: 373%2C E(): 6.5e-17%2C (50.0%25 identity in 114 aa overlap). Contains MIP family signature (PS00221). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;inference=protein motif:PROSITE:PS00221;locus_tag=Rv1578c;product=Probable PhiRv1 phage protein;protein_id=CCP44342.1;transl_table=11
AL123456.3	EMBL	gene	1783309	1783623	.	-	.	ID=gene-Rv1579c;Name=Rv1579c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1579c
AL123456.3	EMBL	CDS	1783309	1783623	.	-	0	ID=cds-CCP44343.1;Parent=gene-Rv1579c;Dbxref=EnsemblGenomes-Gn:Rv1579c,EnsemblGenomes-Tr:CCP44343,UniProtKB/TrEMBL:O06611,NCBI_GP:CCP44343.1;Name=CCP44343.1;Note=Rv1579c%2C (MTCY336.25)%2C len: 104 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1579c;product=Probable PhiRv1 phage protein;protein_id=CCP44343.1;transl_table=11
AL123456.3	EMBL	gene	1783620	1783892	.	-	.	ID=gene-Rv1580c;Name=Rv1580c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1580c
AL123456.3	EMBL	CDS	1783620	1783892	.	-	0	ID=cds-CCP44344.1;Parent=gene-Rv1580c;Dbxref=EnsemblGenomes-Gn:Rv1580c,EnsemblGenomes-Tr:CCP44344,UniProtKB/TrEMBL:O06610,NCBI_GP:CCP44344.1;Name=CCP44344.1;Note=Rv1580c%2C (MTCY336.24)%2C len: 90 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1580c;product=Probable PhiRv1 phage protein;protein_id=CCP44344.1;transl_table=11
AL123456.3	EMBL	gene	1783906	1784301	.	-	.	ID=gene-Rv1581c;Name=Rv1581c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1581c
AL123456.3	EMBL	CDS	1783906	1784301	.	-	0	ID=cds-CCP44345.1;Parent=gene-Rv1581c;Dbxref=EnsemblGenomes-Gn:Rv1581c,EnsemblGenomes-Tr:CCP44345,InterPro:IPR001623,UniProtKB/TrEMBL:O06609,NCBI_GP:CCP44345.1;Name=CCP44345.1;Note=Rv1581c%2C (MTCY336.23)%2C len: 131 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1581c;product=Probable PhiRv1 phage protein;protein_id=CCP44345.1;transl_table=11
AL123456.3	EMBL	gene	1784497	1785912	.	-	.	ID=gene-Rv1582c;Name=Rv1582c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1582c
AL123456.3	EMBL	CDS	1784497	1785912	.	-	0	ID=cds-CCP44346.1;Parent=gene-Rv1582c;Dbxref=EnsemblGenomes-Gn:Rv1582c,EnsemblGenomes-Tr:CCP44346,GOA:O06608,InterPro:IPR006500,InterPro:IPR014015,InterPro:IPR014818,InterPro:IPR027417,UniProtKB/TrEMBL:O06608,NCBI_GP:CCP44346.1;Name=CCP44346.1;Note=Rv1582c%2C (MTCY336.22)%2C len: 471 aa. Probable phiRv1 phage protein (see citation below). N-terminus is similar to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519 aa)%2C FASTA scores: opt: 331%2C E(): 6.5e-15%2C (28.5%25 identity in 235 aa overlap)%3B and C-terminus to whole of Q38031 ORF10 of Bacteriophage phi-C31 (202 aa)%2C FASTA scores: opt: 353%2CE(): 1e-16%2C (31.1%25 identity in 190 aa overlap). Also similar to part of AB016282|AB016282_42 Bacteriophage phi-105 (806 aa)%2C FASTA scores: opt: 790%2C E(): 0%2C (32.7%25 identity in 459 aa overlap). Similarity to other phage proteins described as putative DNA-polymerase or DNA-primase. Also slightly similar to MTCY441.24c%2C FASTA scores: E(): 0.0055%2C (36.0%25 identity in 75 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1582c;product=Probable PhiRv1 phage protein;protein_id=CCP44346.1;transl_table=11
AL123456.3	EMBL	gene	1785912	1786310	.	-	.	ID=gene-Rv1583c;Name=Rv1583c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1583c
AL123456.3	EMBL	CDS	1785912	1786310	.	-	0	ID=cds-CCP44347.1;Parent=gene-Rv1583c;Dbxref=EnsemblGenomes-Gn:Rv1583c,EnsemblGenomes-Tr:CCP44347,InterPro:IPR024384,NCBI_GP:CCP44347.1;Name=CCP44347.1;Note=Rv1583c%2C (MTCY336.21)%2C len: 132 aa. Probable phiRv1 phage protein (see citation below)%2C highly similar to Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa)%2C FASTA score: E(): 1.3e-33%2C (81.7%25 identity in 131 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1583c;product=Probable PhiRv1 phage protein;protein_id=CCP44347.1;transl_table=11
AL123456.3	EMBL	gene	1786307	1786528	.	-	.	ID=gene-Rv1584c;Name=Rv1584c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1584c
AL123456.3	EMBL	CDS	1786307	1786528	.	-	0	ID=cds-CCP44348.1;Parent=gene-Rv1584c;Dbxref=EnsemblGenomes-Gn:Rv1584c,EnsemblGenomes-Tr:CCP44348,UniProtKB/TrEMBL:O06606,NCBI_GP:CCP44348.1;Name=CCP44348.1;Note=Rv1584c%2C (MTCY336.20)%2C len: 73 aa. Possible phiRv1 phage protein (putative excisionase) (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1584c;product=Possible PhiRv1 phage protein;protein_id=CCP44348.1;transl_table=11
AL123456.3	EMBL	gene	1786584	1787099	.	-	.	ID=gene-Rv1585c;Name=Rv1585c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1585c
AL123456.3	EMBL	CDS	1786584	1787099	.	-	0	ID=cds-CCP44349.1;Parent=gene-Rv1585c;Dbxref=EnsemblGenomes-Gn:Rv1585c,EnsemblGenomes-Tr:CCP44349,UniProtKB/TrEMBL:O06605,NCBI_GP:CCP44349.1;Name=CCP44349.1;Note=Rv1585c%2C (MTCY336.19)%2C len: 171 aa. Possible phage phiRv1 protein (see Hatfull 2000). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1585c;product=Possible phage PhiRv1 protein;protein_id=CCP44349.1;transl_table=11
AL123456.3	EMBL	gene	1787096	1788505	.	-	.	ID=gene-Rv1586c;Name=Rv1586c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1586c
AL123456.3	EMBL	CDS	1787096	1788505	.	-	0	ID=cds-CCP44350.1;Parent=gene-Rv1586c;Dbxref=EnsemblGenomes-Gn:Rv1586c,EnsemblGenomes-Tr:CCP44350,GOA:O06604,InterPro:IPR006119,InterPro:IPR011109,InterPro:IPR025827,UniProtKB/TrEMBL:O06604,NCBI_GP:CCP44350.1;Name=CCP44350.1;Note=Rv1586c%2C (MTCY336.18)%2C len: 469 aa. Probable phiRv1 integrase%2C possibly member of the serine family of recombinases (see citation below)%2C similar to several bacteriophage integrases e.g. Q37839 ORF469 protein from Bacteriophage R4 (469 aa)%2C FASTA scores: opt: 623%2C E(): 1.6e-29%2C (31.1%25 identity in 482 aa overlap)%3B and Bacteriophage TP901-1. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1586c;product=Probable PhiRv1 integrase;protein_id=CCP44350.1;transl_table=11
AL123456.3	EMBL	gene	1788162	1789163	.	-	.	ID=gene-Rv1587c;Name=Rv1587c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1587c
AL123456.3	EMBL	CDS	1788162	1789163	.	-	0	ID=cds-CCP44351.1;Parent=gene-Rv1587c;Dbxref=EnsemblGenomes-Gn:Rv1587c,EnsemblGenomes-Tr:CCP44351,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:O06603,NCBI_GP:CCP44351.1;Name=CCP44351.1;Note=Rv1587c%2C (MTCY336.17)%2C len: 333 aa. Partial REP13E12 repeat protein (see citation below)%2C nearly identical (but has been interrupted by phiRv1 prophage) to Q50655|MTCY251.13c|Rv0094c hypothetical 34.6 kDa protein from M. tuberculosis (317 aa)%2C FASTA results: opt: 1511%2CE(): 1.1e-84%2C (97.75%25 identity in 224 aa overlap). Codon usage suggests that translation may involve frameshifting of Rv1588c mRNA in poly_C stretch into reading frame of Rv1587c. 3' end found in Rv1572c. Length extended since first submission (+115 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1587c;product=Partial REP13E12 repeat protein;protein_id=CCP44351.1;transl_table=11
AL123456.3	EMBL	repeat_region	1788514	1788525	.	-	.	ID=id-Rv1587c;Note=12 bp direct repeat 2%2C ccacggccaacc%2C flanking phage-like element%2C first site at 1779266..1779277. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region;locus_tag=Rv1587c
AL123456.3	EMBL	repeat_region	1788514	1789811	.	-	.	ID=id-AL123456.3:1788514..1789811;Note=REP-5%2C len: 1298 nt. REP336%2C member of REP13E12 family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	1789168	1789836	.	-	.	ID=gene-Rv1588c;Name=Rv1588c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1588c
AL123456.3	EMBL	CDS	1789168	1789836	.	-	0	ID=cds-CCP44352.1;Parent=gene-Rv1588c;Dbxref=EnsemblGenomes-Gn:Rv1588c,EnsemblGenomes-Tr:CCP44352,GOA:P9WLT9,InterPro:IPR003870,NCBI_GP:CCP44352.1;Name=CCP44352.1;Note=Rv1588c%2C (MTCY336.16)%2C len: 222 aa. Partial REP13E12 repeat protein (see citation below)%2C nearly identical to ORF's in other Rep13E12 repeats%2C including Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypothetical 15.4 kd protein cy251.14 from Mycobacterium tuberculosis (136 aa)%2CFASTA results: opt: 613%2C E(): 9.9e-29%2C (86.5%25 identity in 111 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1588c;product=Partial REP13E12 repeat protein;protein_id=CCP44352.1;transl_table=11
AL123456.3	EMBL	gene	1790284	1791333	.	+	.	ID=gene-Rv1589;Name=bioB;gbkey=Gene;gene=bioB;gene_biotype=protein_coding;locus_tag=Rv1589
AL123456.3	EMBL	CDS	1790284	1791333	.	+	0	ID=cds-CCP44353.1;Parent=gene-Rv1589;Dbxref=EnsemblGenomes-Gn:Rv1589,EnsemblGenomes-Tr:CCP44353,GOA:P9WPQ7,InterPro:IPR002684,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR010722,InterPro:IPR013785,InterPro:IPR024177,NCBI_GP:CCP44353.1;Name=CCP44353.1;Note=Rv1589%2C (MTCY336.15c)%2C len: 349 aa. Probable bioB%2Cbiotin synthetase O06601. Highly similar to BIOB_MYCLE|P46715 BioB from Mycobacterium leprae (345 aa)%2CFASTA results: opt: 1982%2C E(): 0%2C (86.5%25 identity in 349 aa overlap). Identical to AF041819|AF041819_9 bioB from Mycobacterium bovis BCG (349 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bioB;locus_tag=Rv1589;product=Probable biotin synthetase BioB;protein_id=CCP44353.1;transl_table=11
AL123456.3	EMBL	gene	1791334	1791573	.	+	.	ID=gene-Rv1590;Name=Rv1590;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1590
AL123456.3	EMBL	CDS	1791334	1791573	.	+	0	ID=cds-CCP44354.1;Parent=gene-Rv1590;Dbxref=EnsemblGenomes-Gn:Rv1590,EnsemblGenomes-Tr:CCP44354,GOA:P9WLT7,NCBI_GP:CCP44354.1;Name=CCP44354.1;Note=Rv1590%2C (MTCY336.14c)%2C len: 79 aa. Conserved hypothetical protein%2C similar to Q49616|LEPB1170_C1_162|YF90_MYCLE from Mycobacterium leprae (80 aa)%2C FASTA scores: opt: 368%2C E(): 1.7e-21%2CSmith-Waterman score: 368%2C (67.1%25 identity in 73 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv1590;product=Conserved hypothetical protein;protein_id=CCP44354.1;transl_table=11
AL123456.3	EMBL	gene	1791570	1792235	.	+	.	ID=gene-Rv1591;Name=Rv1591;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1591
AL123456.3	EMBL	CDS	1791570	1792235	.	+	0	ID=cds-CCP44355.1;Parent=gene-Rv1591;Dbxref=EnsemblGenomes-Gn:Rv1591,EnsemblGenomes-Tr:CCP44355,GOA:P9WLT5,InterPro:IPR021213,NCBI_GP:CCP44355.1;Name=CCP44355.1;Note=Rv1591%2C (MTCY336.13c)%2C len: 221 aa. Probable transmembrane protein%2C similar to Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical Mycobacterium leprae protein (198 aa)%2C FASTA results: opt: 802%2C E(): 0%2C (63.8%25 identity in 188 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1591;product=Probable transmembrane protein;protein_id=CCP44355.1;transl_table=11
AL123456.3	EMBL	gene	1792400	1793740	.	-	.	ID=gene-Rv1592c;Name=Rv1592c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1592c
AL123456.3	EMBL	CDS	1792400	1793740	.	-	0	ID=cds-CCP44356.1;Parent=gene-Rv1592c;Dbxref=EnsemblGenomes-Gn:Rv1592c,EnsemblGenomes-Tr:CCP44356,GOA:P9WK89,InterPro:IPR005152,InterPro:IPR029058,NCBI_GP:CCP44356.1;Name=CCP44356.1;Note=Rv1592c%2C (MTCY336.12)%2C len: 446 aa. Conserved hypothetical protein%2C some similarity to Q49629|B1170_F1_46 from Mycobacterium leprae (132 aa)%2C FASTA results: opt: 332%2C E(): 4.5e-14%2C (56.3%25 identity in 87 aa overlap). Nearly identical to truncated Mycobacterium bovis BCG protein (148 aa) AF041819|AF041819_11.;gbkey=CDS;locus_tag=Rv1592c;product=Conserved hypothetical protein;protein_id=CCP44356.1;transl_table=11
AL123456.3	EMBL	gene	1793997	1794707	.	-	.	ID=gene-Rv1593c;Name=Rv1593c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1593c
AL123456.3	EMBL	CDS	1793997	1794707	.	-	0	ID=cds-CCP44357.1;Parent=gene-Rv1593c;Dbxref=EnsemblGenomes-Gn:Rv1593c,EnsemblGenomes-Tr:CCP44357,GOA:O06597,InterPro:IPR000086,InterPro:IPR011991,InterPro:IPR015797,UniProtKB/TrEMBL:O06597,NCBI_GP:CCP44357.1;Name=CCP44357.1;Note=Rv1593c%2C (MTCY336.11)%2C len: 236 aa. Conserved protein%2C highly similar to Q49628|B1170_F1_44 from Mycobacterium leprae (286 aa)%2C FASTA scores: opt: 1304%2C E (): 0%2C (85.4%25 identity in 233 aa overlap)%3B similar to several putative DNA hydrolases e.g. Q9S233|SCI51.07C from Streptomyces coelicolor (239 aa)%2C FASTA scores: opt: 415%2CE(): 4.6e-20%2C (34.8%25 identity in 221 aa overlap)%3B also similar to P74291|SLR1690 hypothetical protein from synechocystis (261 aa)%2C FASTA scores: opt: 228%2C E(): 1.4e-17%2C (31.5%25 identity in 213 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1593c;product=Conserved protein;protein_id=CCP44357.1;transl_table=11
AL123456.3	EMBL	gene	1794756	1795805	.	+	.	ID=gene-Rv1594;Name=nadA;gbkey=Gene;gene=nadA;gene_biotype=protein_coding;locus_tag=Rv1594
AL123456.3	EMBL	CDS	1794756	1795805	.	+	0	ID=cds-CCP44358.1;Parent=gene-Rv1594;Dbxref=EnsemblGenomes-Gn:Rv1594,EnsemblGenomes-Tr:CCP44358,GOA:P9WJK1,InterPro:IPR003473,InterPro:IPR023066,NCBI_GP:CCP44358.1;Name=CCP44358.1;Note=Rv1594%2C (MTCY336.10c)%2C len: 349 aa. Probable nadA%2Cquinolinate synthetase. Similar to many e.g. Q49622 NADA from Mycobacterium leprae (368 aa)%2C FASTA results: opt: 1994%2C E(): 0%2C (84.4%25 identity in 352 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nadA;locus_tag=Rv1594;product=Probable quinolinate synthetase NadA;protein_id=CCP44358.1;transl_table=11
AL123456.3	EMBL	gene	1795805	1797388	.	+	.	ID=gene-Rv1595;Name=nadB;gbkey=Gene;gene=nadB;gene_biotype=protein_coding;locus_tag=Rv1595
AL123456.3	EMBL	CDS	1795805	1797388	.	+	0	ID=cds-CCP44359.1;Parent=gene-Rv1595;Dbxref=EnsemblGenomes-Gn:Rv1595,EnsemblGenomes-Tr:CCP44359,GOA:P9WJJ9,InterPro:IPR003953,InterPro:IPR005288,InterPro:IPR013027,InterPro:IPR015939,InterPro:IPR027477,NCBI_GP:CCP44359.1;Name=CCP44359.1;Note=Rv1595%2C (MTCY336.09c)%2C len: 527 aa. Probable nadB%2CL-aspartate oxidase. Similar to many e.g. Q49617 L-aspartate oxidase (quinolinate synthetase) from Mycobacterium leprae (424 aa)%2C FASTA results: opt: 2152%2CE(): 0%2C (82.0%25 identity in 400 aa overlap). Also shows some similarity to Rv1552 frdA from Mycobacterium tuberculosis (583 aa)%2C FASTA results: E(): 1e-10%2C (35.3%25 identity in 566 aa overlap). Heterodimer. The quinolinate synthetase complex consists of the two enzymes quinolinate synthetase a and B.;gbkey=CDS;gene=nadB;locus_tag=Rv1595;product=Probable L-aspartate oxidase NadB;protein_id=CCP44359.1;transl_table=11
AL123456.3	EMBL	gene	1797388	1798245	.	+	.	ID=gene-Rv1596;Name=nadC;gbkey=Gene;gene=nadC;gene_biotype=protein_coding;locus_tag=Rv1596
AL123456.3	EMBL	CDS	1797388	1798245	.	+	0	ID=cds-CCP44360.1;Parent=gene-Rv1596;Dbxref=EnsemblGenomes-Gn:Rv1596,EnsemblGenomes-Tr:CCP44360,GOA:P9WJJ7,InterPro:IPR002638,InterPro:IPR004393,InterPro:IPR013785,InterPro:IPR022412,InterPro:IPR027277,PDB:1QPN,PDB:1QPO,PDB:1QPQ,PDB:1QPR,NCBI_GP:CCP44360.1;Name=CCP44360.1;Note=Rv1596%2C (MTCY336.08c)%2C len: 285 aa. Probable nadC%2Cnicotinate-nucleotide pyrophosphatase O06594. Similar to many e.g. ADC_MYCLE|P46714 from Mycobacterium leprae (284 aa)%2C FASTA results: opt: 1418%2C E(): 0%2C(79.2%25 identity in 283 aa overlap). Belongs to the NADC/MODD family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nadC;locus_tag=Rv1596;product=Probable nicotinate-nucleotide pyrophosphatase NadC;protein_id=CCP44360.1;transl_table=11
AL123456.3	EMBL	gene	1798294	1799052	.	+	.	ID=gene-Rv1597;Name=Rv1597;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1597
AL123456.3	EMBL	CDS	1798294	1799052	.	+	0	ID=cds-CCP44361.1;Parent=gene-Rv1597;Dbxref=EnsemblGenomes-Gn:Rv1597,EnsemblGenomes-Tr:CCP44361,GOA:O06593,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:O06593,NCBI_GP:CCP44361.1;Name=CCP44361.1;Note=Rv1597%2C (MTCY336.07c)%2C len: 252 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1597;product=Hypothetical protein;protein_id=CCP44361.1;transl_table=11
AL123456.3	EMBL	gene	1799073	1799483	.	-	.	ID=gene-Rv1598c;Name=Rv1598c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1598c
AL123456.3	EMBL	CDS	1799073	1799483	.	-	0	ID=cds-CCP44362.1;Parent=gene-Rv1598c;Dbxref=EnsemblGenomes-Gn:Rv1598c,EnsemblGenomes-Tr:CCP44362,GOA:O06592,InterPro:IPR004378,UniProtKB/TrEMBL:O06592,NCBI_GP:CCP44362.1;Name=CCP44362.1;Note=Rv1598c%2C (MTCY336.06)%2C len: 136 aa. Conserved protein%2C some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa)%2C FASTA scores: E(): 2.2e-09%2C (38.4%25 identity in 99 aa overlap)%3B and P95144|MTCY359.02|Rv1871c (129 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1598c;product=Conserved protein;protein_id=CCP44362.1;transl_table=11
AL123456.3	EMBL	gene	1799583	1800899	.	+	.	ID=gene-Rv1599;Name=hisD;gbkey=Gene;gene=hisD;gene_biotype=protein_coding;locus_tag=Rv1599
AL123456.3	EMBL	CDS	1799583	1800899	.	+	0	ID=cds-CCP44363.1;Parent=gene-Rv1599;Dbxref=EnsemblGenomes-Gn:Rv1599,EnsemblGenomes-Tr:CCP44363,GOA:P9WNW9,InterPro:IPR001692,InterPro:IPR012131,InterPro:IPR016161,InterPro:IPR022695,NCBI_GP:CCP44363.1;Name=CCP44363.1;Note=Rv1599%2C (MTCY336.05c)%2C len: 438 aa. Probable hisD%2Chistidinol dehydrogenase (see citation below) O08396. Similar to many e.g. HISX_MYCSM|P28736 from Mycobacterium smegmatis (445 aa)%2C FASTA results: opt: 2356%2C E(): 0%2C(83.1%25 identity in 437 aa overlap). Contains histidinol dehydrogenase signature (PS00611).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisD;inference=protein motif:PROSITE:PS00611;locus_tag=Rv1599;product=Probable histidinol dehydrogenase HisD (HDH);protein_id=CCP44363.1;transl_table=11
AL123456.3	EMBL	gene	1800896	1802038	.	+	.	ID=gene-Rv1600;Name=hisC1;gbkey=Gene;gene=hisC1;gene_biotype=protein_coding;gene_synonym=hisC;locus_tag=Rv1600
AL123456.3	EMBL	CDS	1800896	1802038	.	+	0	ID=cds-CCP44364.1;Parent=gene-Rv1600;Dbxref=EnsemblGenomes-Gn:Rv1600,EnsemblGenomes-Tr:CCP44364,GOA:P9WML7,InterPro:IPR001917,InterPro:IPR004839,InterPro:IPR005861,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP44364.1;Name=CCP44364.1;Note=Rv1600%2C (MTCY336.04c)%2C len: 380 aa. Probable hisC1%2Chistidinol-phosphate aminotransferase O06591. Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces coelicolor (369 aa)%2C FASTA results: opt: 1353%2C E(): 0%2C (59.0%25 identity in 356 aa overlap). Some similarity to other Mycobacterium tuberculosis aminotransferases e.g. Rv3772|MTCY13D12.06%2CFASTA results: E(): 7.4e-25%2C (33.7%25 identity in 365 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). Belongs to class-II of pyridoxal-phosphate-dependent aminotransferases. Note that previously known as hisC.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisC1;inference=protein motif:PROSITE:PS00599;locus_tag=Rv1600;product=Probable histidinol-phosphate aminotransferase HisC1;protein_id=CCP44364.1;transl_table=11
AL123456.3	EMBL	gene	1802035	1802667	.	+	.	ID=gene-Rv1601;Name=hisB;gbkey=Gene;gene=hisB;gene_biotype=protein_coding;locus_tag=Rv1601
AL123456.3	EMBL	CDS	1802035	1802667	.	+	0	ID=cds-CCP44365.1;Parent=gene-Rv1601;Dbxref=EnsemblGenomes-Gn:Rv1601,EnsemblGenomes-Tr:CCP44365,GOA:P9WML9,InterPro:IPR000807,InterPro:IPR020565,InterPro:IPR020568,PDB:4GQU,NCBI_GP:CCP44365.1;Name=CCP44365.1;Note=Rv1601%2C (MTCY336.03c)%2C len: 210 aa. Probable hisB%2Cimidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa)%2CFASTA results: opt: 763%2C E(): 0%2C (57.4%25 identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisB;locus_tag=Rv1601;product=Probable imidazole glycerol-phosphate dehydratase HisB;protein_id=CCP44365.1;transl_table=11
AL123456.3	EMBL	gene	1802664	1803284	.	+	.	ID=gene-Rv1602;Name=hisH;gbkey=Gene;gene=hisH;gene_biotype=protein_coding;locus_tag=Rv1602
AL123456.3	EMBL	CDS	1802664	1803284	.	+	0	ID=cds-CCP44366.1;Parent=gene-Rv1602;Dbxref=EnsemblGenomes-Gn:Rv1602,EnsemblGenomes-Tr:CCP44366,GOA:P9WMM1,InterPro:IPR010139,InterPro:IPR017926,InterPro:IPR029062,NCBI_GP:CCP44366.1;Name=CCP44366.1;Note=Rv1602%2C (MTCY336.02c)%2C len: 206 aa. Probable hisH%2Camidotransferase. Similar to many e.g. HIS5_STRCO|P16249 from Streptomyces coelicolor (222 aa)%2C FASTA results: opt: 872%2C E():0%2C (61.0%25 identity in 210 aa overlap). Contains glutamine amidotransferases class-I active site (PS00442). Belongs to the HisH family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisH;inference=protein motif:PROSITE:PS00442;locus_tag=Rv1602;product=Probable amidotransferase HisH;protein_id=CCP44366.1;transl_table=11
AL123456.3	EMBL	gene	1803294	1804031	.	+	.	ID=gene-Rv1603;Name=hisA;gbkey=Gene;gene=hisA;gene_biotype=protein_coding;locus_tag=Rv1603
AL123456.3	EMBL	CDS	1803294	1804031	.	+	0	ID=cds-CCP44367.1;Parent=gene-Rv1603;Dbxref=EnsemblGenomes-Gn:Rv1603,EnsemblGenomes-Tr:CCP44367,GOA:P9WMM5,InterPro:IPR006062,InterPro:IPR010188,InterPro:IPR011060,InterPro:IPR013785,InterPro:IPR023016,PDB:2Y85,PDB:2Y88,PDB:2Y89,PDB:3ZS4,NCBI_GP:CCP44367.1;Name=CCP44367.1;Note=Rv1603%2C (MTV046.01-MTCY336.01c)%2C len: 245 aa. Probable hisA%2C phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase%2C similar to many e.g. HIS4_STRCO|P16250 phosphoribosylformimino-5-aminoimidaz from Streptomyces coelicolor (240 aa)%2C FASTA scores: opt: 1081%2C E(): 0%2C (69.0%25 identity in 239 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisA;locus_tag=Rv1603;product=Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA;protein_id=CCP44367.1;transl_table=11
AL123456.3	EMBL	gene	1804039	1804851	.	+	.	ID=gene-Rv1604;Name=impA;gbkey=Gene;gene=impA;gene_biotype=protein_coding;locus_tag=Rv1604
AL123456.3	EMBL	CDS	1804039	1804851	.	+	0	ID=cds-CCP44368.1;Parent=gene-Rv1604;Dbxref=EnsemblGenomes-Gn:Rv1604,EnsemblGenomes-Tr:CCP44368,GOA:O53907,InterPro:IPR000760,InterPro:IPR020550,NCBI_GP:CCP44368.1;Name=CCP44368.1;Note=Rv1604%2C (MTV046.02)%2C len: 270 aa. Probable impA%2Cinositol monophosphatase%2C similar to many e.g. AF0059|AF005905_2 inositol monophosphate phosphatase from Mycobacterium smegmatis (276 aa)%2C FASTA scores: opt: 1241%2CE(): 0%2C (70.5%25 identity in 261 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv3137 and Rv2701c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=impA;locus_tag=Rv1604;product=Probable inositol-monophosphatase ImpA (imp);protein_id=CCP44368.1;transl_table=11
AL123456.3	EMBL	gene	1804853	1805656	.	+	.	ID=gene-Rv1605;Name=hisF;gbkey=Gene;gene=hisF;gene_biotype=protein_coding;locus_tag=Rv1605
AL123456.3	EMBL	CDS	1804853	1805656	.	+	0	ID=cds-CCP44369.1;Parent=gene-Rv1605;Dbxref=EnsemblGenomes-Gn:Rv1605,EnsemblGenomes-Tr:CCP44369,GOA:P9WMM3,InterPro:IPR004651,InterPro:IPR006062,InterPro:IPR011060,InterPro:IPR013785,NCBI_GP:CCP44369.1;Name=CCP44369.1;Note=Rv1605%2C (MTV046.03)%2C len: 267 aa. Probable hisF%2Ccyclase involved in histidine biosynthetic pathway%2C similar to many e.g. AF0304|AF030405_1 Corynebacterium glutamicum cyclase (257 aa)%2C FASTA scores: opt: 1201%2C E(): 0%2C (71.9%25 identity in 256 aa overlap). Belongs to the HisA/HisF family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisF;locus_tag=Rv1605;product=Probable cyclase HisF;protein_id=CCP44369.1;transl_table=11
AL123456.3	EMBL	gene	1805653	1806000	.	+	.	ID=gene-Rv1606;Name=hisI;gbkey=Gene;gene=hisI;gene_biotype=protein_coding;locus_tag=Rv1606
AL123456.3	EMBL	CDS	1805653	1806000	.	+	0	ID=cds-CCP44370.1;Parent=gene-Rv1606;Dbxref=EnsemblGenomes-Gn:Rv1606,EnsemblGenomes-Tr:CCP44370,GOA:P9WMM7,InterPro:IPR002496,InterPro:IPR026660,NCBI_GP:CCP44370.1;Name=CCP44370.1;Note=Rv1606%2C (MTV046.04)%2C len: 115 aa. Probable hisI%2Cphosphoribosyl-AMP 1%2C6 cyclohydrolase%2C similar to several e.g. X82010|RSHISI_2 HISI from Rhodobacter sphaeroides (119 aa)%2C FASTA scores: opt: 378%2C E(): 2.8e-21%2C (52.3%25 identity in 109 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisI;locus_tag=Rv1606;product=Probable phosphoribosyl-AMP 1%2C6 cyclohydrolase HisI;protein_id=CCP44370.1;transl_table=11
AL123456.3	EMBL	gene	1806181	1807263	.	+	.	ID=gene-Rv1607;Name=chaA;gbkey=Gene;gene=chaA;gene_biotype=protein_coding;locus_tag=Rv1607
AL123456.3	EMBL	CDS	1806181	1807263	.	+	0	ID=cds-CCP44371.1;Parent=gene-Rv1607;Dbxref=EnsemblGenomes-Gn:Rv1607,EnsemblGenomes-Tr:CCP44371,GOA:O53910,InterPro:IPR004837,UniProtKB/TrEMBL:O53910,NCBI_GP:CCP44371.1;Name=CCP44371.1;Note=Rv1607%2C (MTV046.05)%2C len: 360 aa. Probable chaA%2Cionic transporter integral membrane protein%2C putative calcium/proton antiporter%2C similar to many e.g. P31801|CHAA_ECOLI calcium/proton antiporter from Escherichia coli (366 aa)%2C FASTA scores: opt: 736%2C E(): 0%2C(35.9%25 identity in 351 aa overlap). Equivalent to Mycobacterium leprae AL049913|MLCB1610_21 (77.7%25 identity in 364 aa overlap). Seems to belong to the CaCA family.;gbkey=CDS;gene=chaA;locus_tag=Rv1607;product=Probable ionic transporter integral membrane protein ChaA;protein_id=CCP44371.1;transl_table=11
AL123456.3	EMBL	gene	1807298	1807762	.	-	.	ID=gene-Rv1608c;Name=bcpB;gbkey=Gene;gene=bcpB;gene_biotype=protein_coding;locus_tag=Rv1608c
AL123456.3	EMBL	CDS	1807298	1807762	.	-	0	ID=cds-CCP44372.1;Parent=gene-Rv1608c;Dbxref=EnsemblGenomes-Gn:Rv1608c,EnsemblGenomes-Tr:CCP44372,GOA:P9WID9,InterPro:IPR000866,InterPro:IPR012336,NCBI_GP:CCP44372.1;Name=CCP44372.1;Note=Rv1608c%2C (MTV046.06)%2C len: 154 aa. Probable bcpB%2Cperoxidoxin or bacterioferritin comigratory protein%2Csimilar to many%2C e.g. AE0003|ECAE000335_4 bacterioferritin comigratory protein from Escherichia coli K-12 MG1655 (156 aa)%2C FASTA scores: opt: 329%2C E(): 1.2e-16%2C (38.2%25 identity in 152 aa overlap)%3B Z97179|MLCL383_22 Mycobacterium leprae cosmid L383 (161 aa) (40.2%25 identity in 132 aa overlap). Also similar to Rv2428 AhpC%2C alkyl hydroperoxide reductase from Mycobacterium tuberculosis%3B and other Mycobacterium tuberculosis putative peroxidoxins Rv2521%2C Rv2238c%2CRv1932.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bcpB;locus_tag=Rv1608c;product=Probable peroxidoxin BcpB;protein_id=CCP44372.1;transl_table=11
AL123456.3	EMBL	gene	1807903	1809453	.	+	.	ID=gene-Rv1609;Name=trpE;gbkey=Gene;gene=trpE;gene_biotype=protein_coding;locus_tag=Rv1609
AL123456.3	EMBL	CDS	1807903	1809453	.	+	0	ID=cds-CCP44373.1;Parent=gene-Rv1609;Dbxref=EnsemblGenomes-Gn:Rv1609,EnsemblGenomes-Tr:CCP44373,GOA:P9WFX3,InterPro:IPR005256,InterPro:IPR005801,InterPro:IPR006805,InterPro:IPR015890,InterPro:IPR019999,NCBI_GP:CCP44373.1;Name=CCP44373.1;Note=Rv1609%2C (MTCY01B2.01%2C MTV046.07)%2C len: 516 aa. trpE%2Canthranilate synthase component I. FASTA best: TRPE_CLOTM|P14953 anthranilate synthase component I from Clostridium thermocellum (494 aa)%2C E(): 0%2C (42.6%25 identity in 498 aa overlap). Some similarity to Rv2386c|MTCY253.35%2CE(): 6.3e-17%3B and Rv3215|MTCY07D11.11c%2C E(): 5.7e-15. Belongs to the anthranilate synthase component I family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trpE;locus_tag=Rv1609;product=Anthranilate synthase component I TrpE (glutamine amidotransferase);protein_id=CCP44373.1;transl_table=11
AL123456.3	EMBL	gene	1809443	1810150	.	+	.	ID=gene-Rv1610;Name=Rv1610;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1610
AL123456.3	EMBL	CDS	1809443	1810150	.	+	0	ID=cds-CCP44374.1;Parent=gene-Rv1610;Dbxref=EnsemblGenomes-Gn:Rv1610,EnsemblGenomes-Tr:CCP44374,GOA:O06128,InterPro:IPR011746,InterPro:IPR019051,UniProtKB/TrEMBL:O06128,NCBI_GP:CCP44374.1;Name=CCP44374.1;Note=Rv1610%2C (MTCY01B2.02)%2C len: 235 aa. Possible conserved membrane protein. Equivalent to AL049913|MLCB1610_23 hypothetical protein from Mycobacterium leprae (264 aa)%2C FASTA score: (65.8%25 identity in 231 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1610;product=Possible conserved membrane protein;protein_id=CCP44374.1;transl_table=11
AL123456.3	EMBL	gene	1810240	1811058	.	+	.	ID=gene-Rv1611;Name=trpC;gbkey=Gene;gene=trpC;gene_biotype=protein_coding;locus_tag=Rv1611
AL123456.3	EMBL	CDS	1810240	1811058	.	+	0	ID=cds-CCP44375.1;Parent=gene-Rv1611;Dbxref=EnsemblGenomes-Gn:Rv1611,EnsemblGenomes-Tr:CCP44375,GOA:P9WFX7,InterPro:IPR001468,InterPro:IPR011060,InterPro:IPR013785,InterPro:IPR013798,PDB:3QJA,PDB:3T40,PDB:3T44,PDB:3T55,PDB:3T78,PDB:4FB7,NCBI_GP:CCP44375.1;Name=CCP44375.1;Note=Rv1611%2C (MTCY01B2.03)%2C len: 272 aa. Probable trpC%2Cindole-3-glycerol phosphate synthase. Similar to Q55508|SLR0546 hypothetical 33.0 kDa protein from synechocystis SP (295 aa)%2C FASTA score: opt: 26%2C E(): 7.6e-32%2C (44.2%25 identity in 265 aa overlap)%3B also similar to TRPC_AZOBR|P26938 ndole-3-glycerol-phosphate synthaseindole-3-glycerol-phosphate synthase from Azospirillum brasilense (262 aa)%2C FASTA score: opt: 596%2CE(): 4.8e-30%2C (43.8%25 identity in 258 aa overlap). Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium leprae (272 aa) (90.8%25 identity in 272 aa overlap). Contains indole-3-glycerol phosphate synthase signature (PS00614). Belongs to the TrpC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trpC;inference=protein motif:PROSITE:PS00614;locus_tag=Rv1611;product=Probable indole-3-glycerol phosphate synthase TrpC;protein_id=CCP44375.1;transl_table=11
AL123456.3	EMBL	gene	1811127	1812359	.	+	.	ID=gene-Rv1612;Name=trpB;gbkey=Gene;gene=trpB;gene_biotype=protein_coding;locus_tag=Rv1612
AL123456.3	EMBL	CDS	1811127	1812359	.	+	0	ID=cds-CCP44376.1;Parent=gene-Rv1612;Dbxref=EnsemblGenomes-Gn:Rv1612,EnsemblGenomes-Tr:CCP44376,GOA:P9WFX9,InterPro:IPR001926,InterPro:IPR006653,InterPro:IPR006654,InterPro:IPR023026,PDB:2O2E,PDB:2O2J,NCBI_GP:CCP44376.1;Name=CCP44376.1;Note=Rv1612%2C (MTCY01B2.04)%2C len: 410 aa. TrpB%2C tryptophan synthase beta chain. Equivalent to AL049913|MLCB1610_25 from Mycobacterium leprae (340 aa) (88.5%25 identity in 331 aa overlap). Similar to others e.g. TRPB_CAUCR|P12290 tryptophan synthase beta chain from Caulobacter crescentus (406 aa)%2C FASTA scores: opt: 1662%2C E(): 0%2C (60.6%25 identity in 404 aa overlap). Belongs to the TrpB family. Tetramer of two alpha and two beta chains.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trpB;inference=protein motif:PROSITE:PS00168;locus_tag=Rv1612;product=Tryptophan synthase%2C beta subunit TrpB;protein_id=CCP44376.1;transl_table=11
AL123456.3	EMBL	gene	1812359	1813171	.	+	.	ID=gene-Rv1613;Name=trpA;gbkey=Gene;gene=trpA;gene_biotype=protein_coding;locus_tag=Rv1613
AL123456.3	EMBL	CDS	1812359	1813171	.	+	0	ID=cds-CCP44377.1;Parent=gene-Rv1613;Dbxref=EnsemblGenomes-Gn:Rv1613,EnsemblGenomes-Tr:CCP44377,GOA:P9WFY1,InterPro:IPR002028,InterPro:IPR011060,InterPro:IPR013785,InterPro:IPR018204,NCBI_GP:CCP44377.1;Name=CCP44377.1;Note=Rv1613%2C (MTCY01B2.05)%2C len: 270 aa. Probable trpA%2Ctryptophan synthase alpha chain. FASTA best: O68906|TRPA_MYCIT tryptophan synthase alpha chain from Mycobacterium intracellulare (271 aa)%2C opt: 1442%2C E(): 0%2C(85.3%25 identity in 265 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trpA;locus_tag=Rv1613;product=Probable tryptophan synthase%2C alpha subunit TrpA;protein_id=CCP44377.1;transl_table=11
AL123456.3	EMBL	gene	1813171	1814577	.	+	.	ID=gene-Rv1614;Name=lgt;gbkey=Gene;gene=lgt;gene_biotype=protein_coding;locus_tag=Rv1614
AL123456.3	EMBL	CDS	1813171	1814577	.	+	0	ID=cds-CCP44378.1;Parent=gene-Rv1614;Dbxref=EnsemblGenomes-Gn:Rv1614,EnsemblGenomes-Tr:CCP44378,GOA:P9WK93,InterPro:IPR001640,NCBI_GP:CCP44378.1;Name=CCP44378.1;Note=Rv1614%2C (MTCY01B2.06)%2C len: 468 aa. Possible lgt%2Cprolipoprotein diacylglyceryl transferases%2C similar to many prolipoprotein diacylglyceryl transferases. FASTA scores: LGT_STAAU|P52282 prolipoprotein diacylglyceryl transferase from Staphylococcus aureus subsp. (279 aa)%2C opt: 289%2CE():3.6e- 09%2C (31.5%25 identity in 257 aa overlap)%3B AL096884|SC4G6_3 cosmid 4G6 from Streptomyces coelicolor (343 aa)%2C opt: 735%2C E(): 4e-32%2C (46.5%25 identity in 391 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lgt;locus_tag=Rv1614;product=Possible prolipoprotein diacylglyceryl transferases Lgt;protein_id=CCP44378.1;transl_table=11
AL123456.3	EMBL	gene	1815253	1815693	.	+	.	ID=gene-Rv1615;Name=Rv1615;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1615
AL123456.3	EMBL	CDS	1815253	1815693	.	+	0	ID=cds-CCP44379.1;Parent=gene-Rv1615;Dbxref=EnsemblGenomes-Gn:Rv1615,EnsemblGenomes-Tr:CCP44379,InterPro:IPR007829,UniProtKB/TrEMBL:O06132,NCBI_GP:CCP44379.1;Name=CCP44379.1;Note=Rv1615%2C (MTCY01B2.07)%2C len: 146 aa. Probable membrane protein;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1615;product=Probable membrane protein;protein_id=CCP44379.1;transl_table=11
AL123456.3	EMBL	gene	1815683	1816081	.	+	.	ID=gene-Rv1616;Name=Rv1616;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1616
AL123456.3	EMBL	CDS	1815683	1816081	.	+	0	ID=cds-CCP44380.1;Parent=gene-Rv1616;Dbxref=EnsemblGenomes-Gn:Rv1616,EnsemblGenomes-Tr:CCP44380,InterPro:IPR021215,UniProtKB/TrEMBL:O06133,NCBI_GP:CCP44380.1;Name=CCP44380.1;Note=Rv1616%2C (MTCY01B2.08)%2C len: 132 aa. Conserved membrane protein%2C with some similarity to other hypothetical proteins e.g. AL096884|SC4G6_9 from Streptomyces coelicolor cosmid 4G6 (148 aa)%2C FASTA scores: opt: 245%2C E(): 1.7e-1 0%2C (36.7%25 identity in 128 aa overlap)%3B Q55401|SLL0543 hypothetical 16.5 kDa protein from synechocystis SP (148 aa)%2C FASTA scores: opt: 225%2C E(): 6.5e-10%2C (35.9%25 identity in 117 aa overlap). Has cysteine cluster and contains a rubredoxin signature (PS00202).;gbkey=CDS;inference=protein motif:PROSITE:PS00202;locus_tag=Rv1616;product=Conserved membrane protein;protein_id=CCP44380.1;transl_table=11
AL123456.3	EMBL	gene	1816189	1817607	.	+	.	ID=gene-Rv1617;Name=pykA;gbkey=Gene;gene=pykA;gene_biotype=protein_coding;locus_tag=Rv1617
AL123456.3	EMBL	CDS	1816189	1817607	.	+	0	ID=cds-CCP44381.1;Parent=gene-Rv1617;Dbxref=EnsemblGenomes-Gn:Rv1617,EnsemblGenomes-Tr:CCP44381,GOA:P9WKE5,InterPro:IPR001697,InterPro:IPR011037,InterPro:IPR015793,InterPro:IPR015794,InterPro:IPR015795,InterPro:IPR015806,InterPro:IPR015813,InterPro:IPR018209,NCBI_GP:CCP44381.1;Name=CCP44381.1;Note=Rv1617%2C (MTCY01B2.09)%2C len: 472 aa. Probable pykA%2Cpyruvate kinase. FASTA best: Q46078 pyruvate kinase from corynebacterium glutamicum (475 aa)%2C opt: 2221%2C E(): 0%2C(72.2%25 identity in 468 aa overlap). Belongs to the pyruvate kinase family. Phosphorylated in vitro by PknJ|Rv2088 (See Arora et al.%2C 2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pykA;locus_tag=Rv1617;product=Probable pyruvate kinase PykA;protein_id=CCP44381.1;transl_table=11
AL123456.3	EMBL	gene	1817615	1818517	.	+	.	ID=gene-Rv1618;Name=tesB1;gbkey=Gene;gene=tesB1;gene_biotype=protein_coding;locus_tag=Rv1618
AL123456.3	EMBL	CDS	1817615	1818517	.	+	0	ID=cds-CCP44382.1;Parent=gene-Rv1618;Dbxref=EnsemblGenomes-Gn:Rv1618,EnsemblGenomes-Tr:CCP44382,GOA:O06135,InterPro:IPR003703,InterPro:IPR025652,InterPro:IPR029069,UniProtKB/TrEMBL:O06135,NCBI_GP:CCP44382.1;Name=CCP44382.1;Note=Rv1618%2C (MTCY01B2.10)%2C len: 300 aa. Probable tesB1%2Cacyl-CoA thioesterase II%2C similar to other acyl-CoA thioesterases e.g. TESB_ECOLI|P23911 acyl-CoA thioesterase II from Escherichia coli (285 aa)%2C FASTA scores: opt: 495%2CE(): 2.9e-27%2C (32.5%25 identity in 283 aa overlap)%3B etc. Also similar to Rv2605c|tesB2 from M. tuberculosis.;gbkey=CDS;gene=tesB1;locus_tag=Rv1618;product=Probable acyl-CoA thioesterase II TesB1;protein_id=CCP44382.1;transl_table=11
AL123456.3	EMBL	gene	1818575	1820029	.	+	.	ID=gene-Rv1619;Name=Rv1619;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1619
AL123456.3	EMBL	CDS	1818575	1820029	.	+	0	ID=cds-CCP44383.1;Parent=gene-Rv1619;Dbxref=EnsemblGenomes-Gn:Rv1619,EnsemblGenomes-Tr:CCP44383,GOA:O06136,InterPro:IPR024320,UniProtKB/TrEMBL:O06136,NCBI_GP:CCP44383.1;Name=CCP44383.1;Note=Rv1619%2C (MTCY01B2.11)%2C len: 484 aa. Conserved membrane protein. Some similarity to N-terminus of P94974|Rv1640c|MTCY06H11.04c probable lysyl-tRNA synthetase 2 from Mycobacterium tuberculosis (1172 aa)%2C FASTA scores: E(): 1.4e-16%2C (28.0%25 identity in 410 aa overlap)%3B and similar in part to O69916| SC3C8.03C Putative intergral membrane protein from Streptomyces coelicolor cosmid 3C8 (589 aa)%2C FASTA scores: opt: 453 E(): 8.4e-22%2C (31.3%25 identity in 313 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1619;product=Conserved membrane protein;protein_id=CCP44383.1;transl_table=11
AL123456.3	EMBL	gene	1819963	1821693	.	-	.	ID=gene-Rv1620c;Name=cydC;gbkey=Gene;gene=cydC;gene_biotype=protein_coding;locus_tag=Rv1620c
AL123456.3	EMBL	CDS	1819963	1821693	.	-	0	ID=cds-CCP44384.1;Parent=gene-Rv1620c;Dbxref=EnsemblGenomes-Gn:Rv1620c,EnsemblGenomes-Tr:CCP44384,GOA:O06137,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR011527,InterPro:IPR014223,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O06137,NCBI_GP:CCP44384.1;Name=CCP44384.1;Note=Rv1620c%2C (MTCY01B2.12c)%2C len: 576 aa. Probable cydC%2Ctransmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below)%2C similar to others e.g. CYDC_ECOLI|P23886 transport ATP-binding protein from Escherichia coli (573 aa)%2C FASTA scores: opt: 631%2C E(): 1.6e-30%2C (28.5%25 identity in 569 aa overlap)%3B C-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa)%2C FASTA scores: opt: 956%2C E(): 0%2C (38.8%25 identity in 554 aa overlap)%3B etc. Contains (PS00211) ABC transporters family signature%2C and (PS00017) ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cydC;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1620c;product=Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC;protein_id=CCP44384.1;transl_table=11
AL123456.3	EMBL	gene	1821690	1823273	.	-	.	ID=gene-Rv1621c;Name=cydD;gbkey=Gene;gene=cydD;gene_biotype=protein_coding;locus_tag=Rv1621c
AL123456.3	EMBL	CDS	1821690	1823273	.	-	0	ID=cds-CCP44385.1;Parent=gene-Rv1621c;Dbxref=EnsemblGenomes-Gn:Rv1621c,EnsemblGenomes-Tr:CCP44385,GOA:O06138,InterPro:IPR001140,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR011527,InterPro:IPR014216,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O06138,NCBI_GP:CCP44385.1;Name=CCP44385.1;Note=Rv1621c%2C (MTCY01B2.13c)%2C len: 527 aa. Probable cydD%2Ctransmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below)%2C similar to others e.g. P94366|CYDC_BACSU transport ATP-binding protein from Bacillus subtilis (567 aa)%2C FASTA scores: opt: 784%2C E(): 0%2C(30.1%25 identity in 535 aa overlap)%3B N-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa)%2CFASTA scores: opt: 1295%2C E(): 0%2C (44.6%25 identity in 534 aa overlap)%3B etc. Also similar to Q11019|Y07D_MYCTU from Mycobacterium tuberculosis (579 aa)%2C FASTA scores: opt: 530%2C E(): 6.9e-25%2C (29.1%25 identity in 530 aa overlap). Contains (PS00211) ABC transporters family signature%2C and (PS00017) ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cydD;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1621c;product=Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD;protein_id=CCP44385.1;transl_table=11
AL123456.3	EMBL	gene	1823360	1824400	.	-	.	ID=gene-Rv1622c;Name=cydB;gbkey=Gene;gene=cydB;gene_biotype=protein_coding;locus_tag=Rv1622c
AL123456.3	EMBL	CDS	1823360	1824400	.	-	0	ID=cds-CCP44386.1;Parent=gene-Rv1622c;Dbxref=EnsemblGenomes-Gn:Rv1622c,EnsemblGenomes-Tr:CCP44386,GOA:O06139,InterPro:IPR003317,UniProtKB/TrEMBL:O06139,NCBI_GP:CCP44386.1;Name=CCP44386.1;Note=Rv1622c%2C (MTCY01B2.14c)%2C len: 346 aa. Probable cydB%2Ccytochrome D ubiquinol oxidase subunit II%2C integral membrane protein%2C similar to others e.g. P11027|CYDB_ECOLI cytochrome D ubiquinol oxidase subunit II from Escherichia coli strain K12 (379 aa)%2C FASTA scores: opt: 519%2C E(): 0%2C(32.3%25 identity in 372 aa overlap)%3B P94365|CYDB_BACSU cytochrome D ubiquinol oxidase subunit II from Bacillus subtilis (338 aa)%2C FASTA scores: opt: 824%2C E(): 0%2C (39.5%25 identity in 337 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cydB;locus_tag=Rv1622c;product=Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB (cytochrome BD-I oxidase subunit II);protein_id=CCP44386.1;transl_table=11
AL123456.3	EMBL	gene	1824430	1825887	.	-	.	ID=gene-Rv1623c;Name=cydA;gbkey=Gene;gene=cydA;gene_biotype=protein_coding;gene_synonym=appC;locus_tag=Rv1623c
AL123456.3	EMBL	CDS	1824430	1825887	.	-	0	ID=cds-CCP44387.1;Parent=gene-Rv1623c;Dbxref=EnsemblGenomes-Gn:Rv1623c,EnsemblGenomes-Tr:CCP44387,GOA:L7N662,InterPro:IPR002585,UniProtKB/TrEMBL:L7N662,NCBI_GP:CCP44387.1;Name=CCP44387.1;Note=Rv1623c%2C (MTCY01B2.15c)%2C len: 485 aa. Probable cydA (previously known as appC%2C but renamed cydA to conform with Mycobacterium smegmatis nomenclature)%2C cytochrome D ubiquinol oxidase subunit I%2C integral membrane protein%2Csimilar to others e.g. P26459|APPC_ECOLI|CYXA|CBDA|B0978 cytochrome BD-II oxidase subunit I from Escherichia coli strain K12 (514 aa)%2C FASTA scores: opt: 870%2C E(): 0%2C (35.9%25 identity in 485 aa overlap)%3B AL034355|SCD78_12 from Streptomyces coelicolor (501 aa)%2C FASTA scores: opt: 1099%2CE(): 0%2C (48.6%25 identity in 510 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cydA;locus_tag=Rv1623c;product=Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA (cytochrome BD-I oxidase subunit I);protein_id=CCP44387.1;transl_table=11
AL123456.3	EMBL	gene	1825998	1826585	.	-	.	ID=gene-Rv1624c;Name=Rv1624c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1624c
AL123456.3	EMBL	CDS	1825998	1826585	.	-	0	ID=cds-CCP44388.1;Parent=gene-Rv1624c;Dbxref=EnsemblGenomes-Gn:Rv1624c,EnsemblGenomes-Tr:CCP44388,InterPro:IPR005325,UniProtKB/TrEMBL:O06141,NCBI_GP:CCP44388.1;Name=CCP44388.1;Note=Rv1624c%2C (MTCY01B2.16c)%2C len: 195 aa. Probable membrane protein%2C first start taken. Some similarity to Rv3155 nuoK%2C NADH dehydrogenase chain K from M. tuberculosis. Also similar to AAK72093.1|AF196488 hypothetical protein from Mycobacterium smegmatis (205 aa). Identities %3D 117/195 (60%25).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1624c;product=Probable conserved membrane protein;protein_id=CCP44388.1;transl_table=11
AL123456.3	EMBL	gene	1826614	1827945	.	-	.	ID=gene-Rv1625c;Name=cya;gbkey=Gene;gene=cya;gene_biotype=protein_coding;locus_tag=Rv1625c
AL123456.3	EMBL	CDS	1826614	1827945	.	-	0	ID=cds-CCP44389.1;Parent=gene-Rv1625c;Dbxref=EnsemblGenomes-Gn:Rv1625c,EnsemblGenomes-Tr:CCP44389,GOA:P9WQ35,InterPro:IPR001054,InterPro:IPR018297,InterPro:IPR029787,PDB:1YK9,NCBI_GP:CCP44389.1;Name=CCP44389.1;Note=Rv1625c%2C (MT1661%2C MTCY01B2.17c)%2C len: 443 aa. Cya%2Cmembrane-anchored adenylyl cyclase (see citations below). C-terminal half is similar to region in numerous eukaryotic adenylate and guanylate cyclases. N-terminal half hydrophobic. FASTA score: CYG2_RAT|P22717 guanylate cyclase soluble%2C beta-2 chain (682 aa)%2C FASTA scores: opt: 552%2CE(): 2.7e-26%2C (40.3%25 identity in 226 aa overlap). Some similarity to Rv2435c|MTCY428.11 from Mycobacterium tuberculosis (730 aa)%2C E(): 7e-19. Start changed since first submission (+25 aa). Belongs to adenylyl cyclase class-4/guanylyl cyclase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cya;locus_tag=Rv1625c;product=Membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase);protein_id=CCP44389.1;transl_table=11
AL123456.3	EMBL	gene	1828015	1828088	.	-	.	ID=gene-leuV;Name=leuV;gbkey=Gene;gene=leuV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1828015	1828088	.	-	.	ID=rna-leuV;Parent=gene-leuV;Note=codon recognized: UUG%3B leuV%2C tRNA-Leu%2C anticodon caa%2C length %3D 74;anticodon=(pos:complement(1828052..1828054));gbkey=tRNA;gene=leuV;product=tRNA-Leu
AL123456.3	EMBL	exon	1828015	1828088	.	-	.	ID=exon-leuV-1;Parent=rna-leuV;Note=codon recognized: UUG%3B leuV%2C tRNA-Leu%2C anticodon caa%2C length %3D 74;anticodon=(pos:complement(1828052..1828054));gbkey=tRNA;gene=leuV;product=tRNA-Leu
AL123456.3	EMBL	gene	1828180	1828797	.	+	.	ID=gene-Rv1626;Name=Rv1626;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1626
AL123456.3	EMBL	CDS	1828180	1828797	.	+	0	ID=cds-CCP44390.1;Parent=gene-Rv1626;Dbxref=EnsemblGenomes-Gn:Rv1626,EnsemblGenomes-Tr:CCP44390,GOA:P9WGM3,InterPro:IPR001789,InterPro:IPR005561,InterPro:IPR008327,InterPro:IPR011006,InterPro:IPR011991,PDB:1S8N,PDB:1SD5,NCBI_GP:CCP44390.1;Name=CCP44390.1;Note=Rv1626%2C (MTCY01B2.18)%2C len: 205 aa. Probable two-component response system transcriptional regulator%2Csimilar to many e.g. CHEY_BACSU|P24072 chemotaxis protein chey homolog (119 aa)%2C FASTA scores: opt: 283%2C E(): 1.6e-16%2C (43.0%25 identity in 114 aa overlap). Also similar to AL109732|SC7H2_27 hypothetical protein from Streptomyces coelicolor (218 aa)%2C opt: 880%2C E(): 0%2C (69.4%25 identity in 196 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1626;product=Probable two-component system transcriptional regulator;protein_id=CCP44390.1;transl_table=11
AL123456.3	EMBL	gene	1828865	1830073	.	-	.	ID=gene-Rv1627c;Name=Rv1627c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1627c
AL123456.3	EMBL	CDS	1828865	1830073	.	-	0	ID=cds-CCP44391.1;Parent=gene-Rv1627c;Dbxref=EnsemblGenomes-Gn:Rv1627c,EnsemblGenomes-Tr:CCP44391,GOA:O06144,InterPro:IPR002155,InterPro:IPR013751,InterPro:IPR016038,InterPro:IPR016039,UniProtKB/TrEMBL:O06144,NCBI_GP:CCP44391.1;Name=CCP44391.1;Note=Rv1627c%2C (MTCY01B2.19c)%2C len: 402 aa. Probable nonspecific lipid-transfer protein%2C similar to many lipid carrier proteins e.g. Q51797 acetyl CoA synthase from Pyrococcus furiosus (388 aa)%2C FASTA scores: opt: 400%2C E(): 3.2e-18%2C (34.4%25 identity in 407 aa overlap)%3B etc. Also some similarity to Mycobacterium tuberculosis proteins Rv3523%2CRv3540c%2C Rv0244%2C Rv2790c%2C Rv1323%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1627c;product=Probable nonspecific lipid-transfer protein;protein_id=CCP44391.1;transl_table=11
AL123456.3	EMBL	gene	1830070	1830561	.	-	.	ID=gene-Rv1628c;Name=Rv1628c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1628c
AL123456.3	EMBL	CDS	1830070	1830561	.	-	0	ID=cds-CCP44392.1;Parent=gene-Rv1628c;Dbxref=EnsemblGenomes-Gn:Rv1628c,EnsemblGenomes-Tr:CCP44392,InterPro:IPR002878,InterPro:IPR012340,InterPro:IPR022002,UniProtKB/TrEMBL:O06145,NCBI_GP:CCP44392.1;Name=CCP44392.1;Note=Rv1628c%2C (MTCY01B2.20c)%2C len: 163 aa. Conserved protein%2C some similarity to others e.g. Q51796 ACAC protein in Pyrococcus furiosus (136 aa)%2C FASTA scores: opt: 199%2CE(): 4.6e-06%2C (34.7%25 identity in 121 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1628c;product=Conserved protein;protein_id=CCP44392.1;transl_table=11
AL123456.3	EMBL	repeat_region	1830074	1830125	.	-	.	ID=id-Rv1628c;Note=52 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region;locus_tag=Rv1628c
AL123456.3	EMBL	gene	1830665	1833379	.	+	.	ID=gene-Rv1629;Name=polA;gbkey=Gene;gene=polA;gene_biotype=protein_coding;locus_tag=Rv1629
AL123456.3	EMBL	CDS	1830665	1833379	.	+	0	ID=cds-CCP44393.1;Parent=gene-Rv1629;Dbxref=EnsemblGenomes-Gn:Rv1629,EnsemblGenomes-Tr:CCP44393,GOA:P9WNU5,InterPro:IPR001098,InterPro:IPR002298,InterPro:IPR002421,InterPro:IPR002562,InterPro:IPR003583,InterPro:IPR008918,InterPro:IPR012337,InterPro:IPR018320,InterPro:IPR019760,InterPro:IPR020045,InterPro:IPR020046,InterPro:IPR029060,NCBI_GP:CCP44393.1;Name=CCP44393.1;Note=Rv1629%2C (MTCY01B2.21)%2C len: 904 aa. Probable polA%2CDNA polymerase I (see citations below). Has DNA polymerase family a signature (PS00447) at C-terminal end. FASTA best: DPO1_MYCTU|Q07700 DNA polymerase I from Mycobacterium tuberculosis (904 aa). Some similarity to Rv2090|MTCY49.30 (393 aa)%2C E(): 2.2e-18%2C (38.7%25 identity in 292 aa overlap). Belongs to DNA polymerase type-a family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=polA;inference=protein motif:PROSITE:PS00447;locus_tag=Rv1629;product=Probable DNA polymerase I PolA;protein_id=CCP44393.1;transl_table=11
AL123456.3	EMBL	gene	1833542	1834987	.	+	.	ID=gene-Rv1630;Name=rpsA;gbkey=Gene;gene=rpsA;gene_biotype=protein_coding;locus_tag=Rv1630
AL123456.3	EMBL	CDS	1833542	1834987	.	+	0	ID=cds-CCP44394.1;Parent=gene-Rv1630;Dbxref=EnsemblGenomes-Gn:Rv1630,EnsemblGenomes-Tr:CCP44394,GOA:P9WH43,InterPro:IPR000110,InterPro:IPR003029,InterPro:IPR012340,InterPro:IPR022967,NCBI_GP:CCP44394.1;Name=CCP44394.1;Note=Rv1630%2C (MTCY01B2.22)%2C len: 481 aa. rpsA%2C 30S ribosomal protein S1. FASTA best: RS1_MYCLE|P46836 30s ribosomal protein S1 from Mycobacterium leprae (482 aa)%2Copt: 2655%2C E(): 0%2C (87.2%25 identity in 483 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsA;locus_tag=Rv1630;product=30S ribosomal protein S1 RpsA;protein_id=CCP44394.1;transl_table=11
AL123456.3	EMBL	gene	1835013	1836236	.	+	.	ID=gene-Rv1631;Name=coaE;gbkey=Gene;gene=coaE;gene_biotype=protein_coding;locus_tag=Rv1631
AL123456.3	EMBL	CDS	1835013	1836236	.	+	0	ID=cds-CCP44395.1;Parent=gene-Rv1631;Dbxref=EnsemblGenomes-Gn:Rv1631,EnsemblGenomes-Tr:CCP44395,GOA:P9WPA3,InterPro:IPR001977,InterPro:IPR007344,InterPro:IPR027417,NCBI_GP:CCP44395.1;Name=CCP44395.1;Note=Rv1631%2C (MTCY01B2.23)%2C len: 407 aa. Probable coaE%2Cdephospho-CoA kinase%2C similar to many e.g. Q50178|ML1383|COAE_MYCLE dephospho-CoA kinase from Mycobacterium leprae (410 aa)%2C FASTA scores: E(): 0%2C (77.5%25 identity in 409 aa overlap). Has ATP/GTP-binding site motif A (P-loop%2C PS00017) at N-terminus. In the N-terminal section%3B belongs to the CoaE family. In the C-terminal section%3B belongs to the UPF0157 (GrpB) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=coaE;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1631;product=Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase);protein_id=CCP44395.1;transl_table=11
AL123456.3	EMBL	gene	1836387	1836830	.	-	.	ID=gene-Rv1632c;Name=Rv1632c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1632c
AL123456.3	EMBL	CDS	1836387	1836830	.	-	0	ID=cds-CCP44396.1;Parent=gene-Rv1632c;Dbxref=EnsemblGenomes-Gn:Rv1632c,EnsemblGenomes-Tr:CCP44396,InterPro:IPR007295,InterPro:IPR014465,UniProtKB/TrEMBL:O06149,NCBI_GP:CCP44396.1;Name=CCP44396.1;Note=Rv1632c%2C (MTCY01B2.24c)%2C len: 147 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1632c;product=Hypothetical protein;protein_id=CCP44396.1;transl_table=11
AL123456.3	EMBL	gene	1837075	1839171	.	+	.	ID=gene-Rv1633;Name=uvrB;gbkey=Gene;gene=uvrB;gene_biotype=protein_coding;locus_tag=Rv1633
AL123456.3	EMBL	CDS	1837075	1839171	.	+	0	ID=cds-CCP44397.1;Parent=gene-Rv1633;Dbxref=EnsemblGenomes-Gn:Rv1633,EnsemblGenomes-Tr:CCP44397,GOA:P9WFC7,InterPro:IPR001650,InterPro:IPR001943,InterPro:IPR004807,InterPro:IPR006935,InterPro:IPR014001,InterPro:IPR024759,InterPro:IPR027417,NCBI_GP:CCP44397.1;Name=CCP44397.1;Note=Rv1633%2C (MTCY01B2.25)%2C len: 698 aa. Probable uvrB%2Cexcinuclease ABC%2C subunit B%3B helicase (see Mizrahi %26 Andersen 1998%3B Sancar 1994)%3B has ATP/GTP-binding site motif A (P-loop%3B PS00017) near N-terminus (see citation below). FASTA best: UVRB_MICLU|P10125 from Micrococcus luteus (709 aa)%2C opt: 3268%2C E(): 0%2C (71.3%25 identity in 704 aa overlap). Also similar to Mycobacterium tuberculosis Rv2973c (recG)%3B and Rv1020 (mfd). Belongs to the UVRB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=uvrB;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1633;product=Probable excinuclease ABC (subunit B-helicase) UvrB;protein_id=CCP44397.1;transl_table=11
AL123456.3	EMBL	gene	1839168	1840583	.	+	.	ID=gene-Rv1634;Name=Rv1634;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1634
AL123456.3	EMBL	CDS	1839168	1840583	.	+	0	ID=cds-CCP44398.1;Parent=gene-Rv1634;Dbxref=EnsemblGenomes-Gn:Rv1634,EnsemblGenomes-Tr:CCP44398,GOA:P9WJX3,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP44398.1;Name=CCP44398.1;Note=Rv1634%2C (MTCY01B2.26)%2C len: 471 aa. Possible drug efflux membrane protein of major facilitator superfamily (MFS)%2C similar to many antibiotic resistance (efflux) proteins. FASTA best: Q56175 TU22 dTDP-glucose dehydrtatase (GRAE) from Streptomyces violaceoruber (557 aa)%2C opt: 415%2CE(): 1.7e-17%2C (26.7%25 identity in 446 aa overlap). Relatives in Mycobacterium tuberculosis: MTCY369.27c%2C E(): 4.8e-12%3B MTCY20B11.14c%2C E(): 2.9e-10.;gbkey=CDS;locus_tag=Rv1634;product=Possible drug efflux membrane protein;protein_id=CCP44398.1;transl_table=11
AL123456.3	EMBL	gene	1840572	1842242	.	-	.	ID=gene-Rv1635c;Name=Rv1635c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1635c
AL123456.3	EMBL	CDS	1840572	1842242	.	-	0	ID=cds-CCP44399.1;Parent=gene-Rv1635c;Dbxref=EnsemblGenomes-Gn:Rv1635c,EnsemblGenomes-Tr:CCP44399,GOA:O06152,UniProtKB/TrEMBL:O06152,NCBI_GP:CCP44399.1;Name=CCP44399.1;Note=Rv1635c%2C (MTCY01B2.27c)%2C len: 556 aa. Probable mannosyltransferase (See Dinadayala et al.%2C 2006). Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Probable conserved transmembrane protein%2C equivalent to CAC31770.1|AL583921 Mycobacterium leprae membrane protein (527 aa)%2C Identities %3D 332/527 (62%25). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv1635c;product=Probable mannosyltransferase. Probable conserved transmembrane protein.;protein_id=CCP44399.1;transl_table=11
AL123456.3	EMBL	gene	1842451	1842891	.	+	.	ID=gene-Rv1636;Name=TB15.3;gbkey=Gene;gene=TB15.3;gene_biotype=protein_coding;locus_tag=Rv1636
AL123456.3	EMBL	CDS	1842451	1842891	.	+	0	ID=cds-CCP44400.1;Parent=gene-Rv1636;Dbxref=EnsemblGenomes-Gn:Rv1636,EnsemblGenomes-Tr:CCP44400,GOA:P9WFC9,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,PDB:1TQ8,NCBI_GP:CCP44400.1;Name=CCP44400.1;Note=Rv1636%2C (MTCY01B2.28)%2C len: 146 aa. TB15.3%2Ciron-regulated universal stress protein family protein (see citations below)%2C similar to other hypothetical proteins from diverse organisms e.g. Q57951|MJ0531|Y531_METJA from Methanococcus jannaschii (170 aa)%2C FASTA scores: opt: 188%2CE(): 6e-06%2C (32.2%25 identity in 149 aa overlap)%3B also P42297|YXIE_BACSU hypothetical 15.9 kDa protein in bglh-wapa intergenic region precursor from Bacillus subtilis (148 aa)%2C FASTA scores: opt: 162%2C E(): 0.00025%2C(30.8%25 identity in 156 aa overlap). Part of family of Mycobacterium tuberculosis hypothetical proteins (but lacks C-terminal region) including Rv2005c%2C Rv2623%2C Rv2026c%2CRv1996%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB15.3;locus_tag=Rv1636;product=Iron-regulated universal stress protein family protein TB15.3;protein_id=CCP44400.1;transl_table=11
AL123456.3	EMBL	gene	1842898	1843692	.	-	.	ID=gene-Rv1637c;Name=Rv1637c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1637c
AL123456.3	EMBL	CDS	1842898	1843692	.	-	0	ID=cds-CCP44401.1;Parent=gene-Rv1637c;Dbxref=EnsemblGenomes-Gn:Rv1637c,EnsemblGenomes-Tr:CCP44401,InterPro:IPR001279,UniProtKB/TrEMBL:O06154,NCBI_GP:CCP44401.1;Name=CCP44401.1;Note=Rv1637c%2C (MTCY01B2.29c%2CMTCY06H11.01c)%2C len: 264 aa. Conserved protein%2C some similarity to others e.g. P05446|GLO2_RHOBL probable hydroxyacylglutathione hydrolase (255 aa)%2C FASTA scores: opt: 252%2C E(): 2e-09%2C (39.0%25 identity in 146 aa overlap). Also similar to Q9Z505|AL035591|SCC54.20 putative hydrolase from Streptomyces coelicolor (218 aa)%2C FASTA scores: opt: 732%2CE(): 0%2C (52.3%25 identity in 220 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins and putative glyoxylases e.g. Rv0634c%2C Rv3677c%2C Rv2581c%2CRv2260.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1637c;product=Conserved protein;protein_id=CCP44401.1;transl_table=11
AL123456.3	EMBL	gene	1843741	1846659	.	+	.	ID=gene-Rv1638;Name=uvrA;gbkey=Gene;gene=uvrA;gene_biotype=protein_coding;locus_tag=Rv1638
AL123456.3	EMBL	CDS	1843741	1846659	.	+	0	ID=cds-CCP44402.1;Parent=gene-Rv1638;Dbxref=EnsemblGenomes-Gn:Rv1638,EnsemblGenomes-Tr:CCP44402,GOA:P9WQK7,InterPro:IPR003439,InterPro:IPR004602,InterPro:IPR013815,InterPro:IPR017871,InterPro:IPR027417,PDB:3ZQJ,NCBI_GP:CCP44402.1;Name=CCP44402.1;Note=Rv1638%2C (MTCY06H11.01%2CMTCY06H11.02c)%2C len: 972 aa. Probable uvrA%2C excinuclease ABC%2C subunit A%3B DNA-binding ATPase (see citations below)%2C similar to many e.g. UVRA_ECOLI|P07671 excinuclease abc subunit A from Escherichia coli (940 aa)%2C FASTA scores: opt: 2573%2C E(): 0%2C(56.2%25 identity in 951 aa overlap). Contains 2x PS00017 ATP/GTP-binding site motif A%2C PS00211 ABC transporters family signature%2C PS00211 ABC transporters family signature. Consists of three subunits%3B UVRA%2C UVRB and UVRC. Belongs to the ABC transporter family. UVRA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=uvrA;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1638;product=Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA;protein_id=CCP44402.1;transl_table=11
AL123456.3	EMBL	gene	1846716	1846973	.	-	.	ID=gene-Rv1638A;Name=Rv1638A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1638A
AL123456.3	EMBL	CDS	1846716	1846973	.	-	0	ID=cds-CCP44403.1;Parent=gene-Rv1638A;Dbxref=EnsemblGenomes-Gn:Rv1638A,EnsemblGenomes-Tr:CCP44403,UniProtKB/TrEMBL:L7N673,NCBI_GP:CCP44403.1;Name=CCP44403.1;Note=Rv1638A%2C len: 85 aa. Conserved hypothetical protein%2Csimilar to C-terminal part of P31511|35KD_MYCTU 35kd immunogenic protein from Mycobacterium tuberculosis (270 aa)%2C FASTA scores: opt: 159%2C E(): 0.002%2C (50.90%25 identity in 55 aa overlap)%3B and to Mycobacterium leprae ML0981 possible pseudogene%2C an orthologue of 35kd immunogenic protein from Mycobacterium tuberculosis. Size difference suggests possible gene fragment.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1638A;product=Conserved hypothetical protein;protein_id=CCP44403.1;transl_table=11
AL123456.3	EMBL	gene	1846989	1848458	.	-	.	ID=gene-Rv1639c;Name=Rv1639c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1639c
AL123456.3	EMBL	CDS	1846989	1848458	.	-	0	ID=cds-CCP44404.1;Parent=gene-Rv1639c;Dbxref=EnsemblGenomes-Gn:Rv1639c,EnsemblGenomes-Tr:CCP44404,InterPro:IPR000801,InterPro:IPR029058,UniProtKB/TrEMBL:P94973,NCBI_GP:CCP44404.1;Name=CCP44404.1;Note=Rv1639c%2C (MTCY06H11.03c)%2C len: 489 aa. Conserved hypothetical membrane protein. Some similarity to P35866|YLI2_CORGL Hypothetical 45.7 kDa protein from Corynebacterium glutamicum (426 aa)%2C FASTA scores: opt: 511%2C E(): 2.4e-23%2C (28.9%25 identity in 370 aa overlap). Contains PS00904 protein phenyltransferases alpha subunit repeat signature;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00904;locus_tag=Rv1639c;product=Conserved hypothetical membrane protein;protein_id=CCP44404.1;transl_table=11
AL123456.3	EMBL	gene	1848517	1852035	.	-	.	ID=gene-Rv1640c;Name=lysX;gbkey=Gene;gene=lysX;gene_biotype=protein_coding;locus_tag=Rv1640c
AL123456.3	EMBL	CDS	1848517	1852035	.	-	0	ID=cds-CCP44405.1;Parent=gene-Rv1640c;Dbxref=EnsemblGenomes-Gn:Rv1640c,EnsemblGenomes-Tr:CCP44405,GOA:P9WFU7,InterPro:IPR002313,InterPro:IPR004364,InterPro:IPR004365,InterPro:IPR006195,InterPro:IPR012340,InterPro:IPR018149,InterPro:IPR018150,InterPro:IPR024320,NCBI_GP:CCP44405.1;Name=CCP44405.1;Note=Rv1640c%2C (MTCY06H11.04c)%2C len: 1172 aa. lysX%2Clysyl-tRNA synthetase 2%2C probable two domain protein. N-terminal part (bases 1850153 to 1852033) is similar to AL023861|SC3C8_3 hypothetical membrane protein from Streptomyces coelicolor (589 aa)%2C Fasta scores: opt: 1426%2CE(): 0%2C (44.6%25 identity in 585 aa overlap). The C-terminal part is similar to SYK_CRILO|P37879 lysyl-tRNA synthetases from Cricetulus longicaudatus (Long-tailed hamster) (597 aa)%2C Fasta scores%2C opt: 985%2C E(): 0%2C (36.8%25 identity in 524 aa overlap). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1%2C PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. This may indicate a frame shift but sequence has been checked and no error found. Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lysX;inference=protein motif:PROSITE:PS00339;locus_tag=Rv1640c;product=Lysyl-tRNA synthetase 2 LysX;protein_id=CCP44405.1;transl_table=11
AL123456.3	EMBL	gene	1852273	1852878	.	+	.	ID=gene-Rv1641;Name=infC;gbkey=Gene;gene=infC;gene_biotype=protein_coding;locus_tag=Rv1641
AL123456.3	EMBL	CDS	1852273	1852878	.	+	0	ID=cds-CCP44406.1;Parent=gene-Rv1641;Dbxref=EnsemblGenomes-Gn:Rv1641,EnsemblGenomes-Tr:CCP44406,GOA:P9WKJ9,InterPro:IPR001288,InterPro:IPR019813,InterPro:IPR019814,InterPro:IPR019815,NCBI_GP:CCP44406.1;Name=CCP44406.1;Note=Rv1641%2C (MTCY06H11.05)%2C len: 201 aa. Probable infC%2Cinitiation factor if-3%2C similar to many e.g. IF3_BACST|P03000 initiation factor if-3 from Bacillus stearothermophilus (171 aa)%2C FASTA scores: opt: 560%2C E(): 1.9e-27%2C (50.6%25 identity in 166 aa overlap). Note that an AUC initiation codon has been used%2C the Bacillus (IF3_BACSU) and Escherichia coli (IF3_ECOLI) proteins use an AUU initiation codon%2C and the Myxococcus xanthus (DSG_MYXXA) homolog uses a AUC. Belongs to the if-3 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=infC;locus_tag=Rv1641;product=Probable initiation factor if-3 InfC;protein_id=CCP44406.1;transl_table=11
AL123456.3	EMBL	gene	1852928	1853122	.	+	.	ID=gene-Rv1642;Name=rpmI;gbkey=Gene;gene=rpmI;gene_biotype=protein_coding;locus_tag=Rv1642
AL123456.3	EMBL	CDS	1852928	1853122	.	+	0	ID=cds-CCP44407.1;Parent=gene-Rv1642;Dbxref=EnsemblGenomes-Gn:Rv1642,EnsemblGenomes-Tr:CCP44407,GOA:P9WH91,InterPro:IPR001706,InterPro:IPR018265,InterPro:IPR021137,NCBI_GP:CCP44407.1;Name=CCP44407.1;Note=Rv1642%2C (MTCY06H11.06)%2C len: 64 aa. rpmI%2C 50S ribosomal protein L35%2C similar to several e.g. RL35_SYNY3|P48959 from Synechocystis sp. (67 aa)%2C fasta scores: opt: 179%2C E(): 2.7e-08%2C (51.6%25 identity in 64 aa overlap). Belongs to the L35P family of ribosomal proteins.;gbkey=CDS;gene=rpmI;locus_tag=Rv1642;product=50S ribosomal protein L35 RpmI;protein_id=CCP44407.1;transl_table=11
AL123456.3	EMBL	gene	1853184	1853573	.	+	.	ID=gene-Rv1643;Name=rplT;gbkey=Gene;gene=rplT;gene_biotype=protein_coding;locus_tag=Rv1643
AL123456.3	EMBL	CDS	1853184	1853573	.	+	0	ID=cds-CCP44408.1;Parent=gene-Rv1643;Dbxref=EnsemblGenomes-Gn:Rv1643,EnsemblGenomes-Tr:CCP44408,GOA:P9WHC5,InterPro:IPR005813,NCBI_GP:CCP44408.1;Name=CCP44408.1;Note=Rv1643%2C (MTCY06H11.07)%2C len: 129 aa. rplT%2C 50S ribosomal protein L20%2C similar to several e.g. RL20_ECOLI|P02421 from Escherichia coli (117 aa)%2C FASTA scores: opt: 438%2C E(): 5.8e-24%2C (60.3%25 identity in 116 aa overlap). Contains PS00937 Ribosomal protein L20 signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplT;inference=protein motif:PROSITE:PS00937;locus_tag=Rv1643;product=50S ribosomal protein L20 RplT;protein_id=CCP44408.1;transl_table=11
AL123456.3	EMBL	gene	1853606	1854388	.	+	.	ID=gene-Rv1644;Name=tsnR;gbkey=Gene;gene=tsnR;gene_biotype=protein_coding;locus_tag=Rv1644
AL123456.3	EMBL	CDS	1853606	1854388	.	+	0	ID=cds-CCP44409.1;Parent=gene-Rv1644;Dbxref=EnsemblGenomes-Gn:Rv1644,EnsemblGenomes-Tr:CCP44409,GOA:P94978,InterPro:IPR001537,InterPro:IPR013123,InterPro:IPR029026,InterPro:IPR029028,InterPro:IPR029064,UniProtKB/TrEMBL:P94978,NCBI_GP:CCP44409.1;Name=CCP44409.1;Note=Rv1644%2C (MTCY06H11.08)%2C len: 260 aa. Possible tsnR%2C23S rRNA methyltransferase%2C similar to several e.g. TSNR_STRLU|P52393 from Streptomyces laurentii (270 aa)%2CFASTA scores: opt: 276%2C E(): 3.6e-11%2C (27.6%25 identity in 261 aa overlap). Also similar to M. tuberculosis hypothetical proteins Rv0881%2C Rv3579c%2C and Rv0380c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tsnR;locus_tag=Rv1644;product=Possible 23S rRNA methyltransferase TsnR;protein_id=CCP44409.1;transl_table=11
AL123456.3	EMBL	gene	1854399	1855454	.	-	.	ID=gene-Rv1645c;Name=Rv1645c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1645c
AL123456.3	EMBL	CDS	1854399	1855454	.	-	0	ID=cds-CCP44410.1;Parent=gene-Rv1645c;Dbxref=EnsemblGenomes-Gn:Rv1645c,EnsemblGenomes-Tr:CCP44410,InterPro:IPR018713,UniProtKB/TrEMBL:P94979,NCBI_GP:CCP44410.1;Name=CCP44410.1;Note=Rv1645c%2C (MTCY06H11.10c)%2C len: 351 aa. Conserved hypothetical protein%2C similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53837|Rv0826|MTV043.18 (351 aa)%2C FASTA scores: (57.5%25 identity in 299 aa overlap)%3B Q10519|Rv2237|YM37_MYCTU (255 aa)%2C O53682|Rv0276 (306 aa).;gbkey=CDS;locus_tag=Rv1645c;product=Conserved hypothetical protein;protein_id=CCP44410.1;transl_table=11
AL123456.3	EMBL	gene	1855764	1856696	.	+	.	ID=gene-Rv1646;Name=PE17;gbkey=Gene;gene=PE17;gene_biotype=protein_coding;locus_tag=Rv1646
AL123456.3	EMBL	CDS	1855764	1856696	.	+	0	ID=cds-CCP44411.1;Parent=gene-Rv1646;Dbxref=EnsemblGenomes-Gn:Rv1646,EnsemblGenomes-Tr:CCP44411,InterPro:IPR000084,UniProtKB/TrEMBL:L7N681,NCBI_GP:CCP44411.1;Name=CCP44411.1;Note=Rv1646%2C (MTCY06H11.11)%2C len: 310 aa. PE17%2C Member of the Mycobacterium tuberculosis PE family of proteins (see citation below)%2C similar to many e.g. YW36_MYCTU|Q10873 hypothetical 53.7 kd protein cy39.36c (558 aa)%2C FASTA scores%2C opt: 411%2C E(): 1.3e-15%2C (34.4%25 identity in 320 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE17;locus_tag=Rv1646;product=PE family protein PE17;protein_id=CCP44411.1;transl_table=11
AL123456.3	EMBL	gene	1856774	1857724	.	+	.	ID=gene-Rv1647;Name=Rv1647;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1647
AL123456.3	EMBL	CDS	1856774	1857724	.	+	0	ID=cds-CCP44412.1;Parent=gene-Rv1647;Dbxref=EnsemblGenomes-Gn:Rv1647,EnsemblGenomes-Tr:CCP44412,GOA:P94982,InterPro:IPR001054,InterPro:IPR029787,UniProtKB/TrEMBL:P94982,NCBI_GP:CCP44412.1;Name=CCP44412.1;Note=Rv1647%2C (MTCY06H11.12)%2C len: 316 aa. Adenylate cyclase%2C some similarity to other Mycobacterium tuberculosis proteins e.g. Q11055|Rv1264|YC64_MYCTU 42.2 kDa protein (397 aa)%2C FASTA scores: opt: 197%2C E(): 9.4e-06%2C(27.1%25 identity in 181 aa overlap) and Q10400|Rv2212|YM12_MYCTU (378 aa). Belongs to adenylyl cyclase class-3 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1647;product=Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);protein_id=CCP44412.1;transl_table=11
AL123456.3	EMBL	gene	1857731	1858537	.	+	.	ID=gene-Rv1648;Name=Rv1648;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1648
AL123456.3	EMBL	CDS	1857731	1858537	.	+	0	ID=cds-CCP44413.1;Parent=gene-Rv1648;Dbxref=EnsemblGenomes-Gn:Rv1648,EnsemblGenomes-Tr:CCP44413,GOA:P94983,UniProtKB/TrEMBL:P94983,NCBI_GP:CCP44413.1;Name=CCP44413.1;Note=Rv1648%2C (MTCY06H11.13)%2C len: 268 aa. Probable transmembrane protein%2C some similarity to Rv3434c|MTCY77.06C (237 aa)%2C FASTA scores: E(): 0.00039%2C(31.4%25 identity in 194 aa overlap).;gbkey=CDS;locus_tag=Rv1648;product=Probable transmembrane protein;protein_id=CCP44413.1;transl_table=11
AL123456.3	EMBL	gene	1858733	1859758	.	+	.	ID=gene-Rv1649;Name=pheS;gbkey=Gene;gene=pheS;gene_biotype=protein_coding;locus_tag=Rv1649
AL123456.3	EMBL	CDS	1858733	1859758	.	+	0	ID=cds-CCP44414.1;Parent=gene-Rv1649;Dbxref=EnsemblGenomes-Gn:Rv1649,EnsemblGenomes-Tr:CCP44414,GOA:P9WFU3,InterPro:IPR002319,InterPro:IPR004188,InterPro:IPR004529,InterPro:IPR006195,InterPro:IPR010978,InterPro:IPR022911,NCBI_GP:CCP44414.1;Name=CCP44414.1;Note=Rv1649%2C (MTCY06H11.14)%2C len: 341 aa. Probable pheS%2CPhenylalanyl-tRNA synthetase alpha chain%2C similar to several e.g. SYFA_ECOLI|P08312 from Escherichia coli (327 aa)%2C FASTA scores: opt: 978%2C E(): 0%2C (46.5%25 identity in 331 aa overlap). Homology suggests this start site%2C but there is a potential rbs upstream of a gtg 30 bp upstream%3B contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to class-II aminoacyl-tRNA synthetase family. PHE-tRNA synthetase alpha chain subfamily 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pheS;inference=protein motif:PROSITE:PS00179;locus_tag=Rv1649;product=Probable phenylalanyl-tRNA synthetase%2C alpha chain PheS;protein_id=CCP44414.1;transl_table=11
AL123456.3	EMBL	gene	1859758	1862253	.	+	.	ID=gene-Rv1650;Name=pheT;gbkey=Gene;gene=pheT;gene_biotype=protein_coding;locus_tag=Rv1650
AL123456.3	EMBL	CDS	1859758	1862253	.	+	0	ID=cds-CCP44415.1;Parent=gene-Rv1650;Dbxref=EnsemblGenomes-Gn:Rv1650,EnsemblGenomes-Tr:CCP44415,GOA:P9WFU1,InterPro:IPR002547,InterPro:IPR004532,InterPro:IPR005121,InterPro:IPR005146,InterPro:IPR005147,InterPro:IPR009061,InterPro:IPR012340,InterPro:IPR020825,NCBI_GP:CCP44415.1;Name=CCP44415.1;Note=Rv1650%2C (MTCY06H11.15)%2C len: 831 aa. Probable pheT%2CPhenylalanyl-tRNA synthetase beta chain%2C similar to several e.g. SYFB_ECOLI|P07395 from Escherichia coli (795 aa)%2CFASTA scores: opt: 995%2C E(): 0%2C (31.8%25 identity in 847 aa overlap). Belongs to the phenylalanyl-tRNA synthetase beta chain family - subfamily 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pheT;locus_tag=Rv1650;product=Probable phenylalanyl-tRNA synthetase%2C beta chain PheT;protein_id=CCP44415.1;transl_table=11
AL123456.3	EMBL	gene	1862347	1865382	.	-	.	ID=gene-Rv1651c;Name=PE_PGRS30;gbkey=Gene;gene=PE_PGRS30;gene_biotype=protein_coding;locus_tag=Rv1651c
AL123456.3	EMBL	CDS	1862347	1865382	.	-	0	ID=cds-CCP44416.1;Parent=gene-Rv1651c;Dbxref=EnsemblGenomes-Gn:Rv1651c,EnsemblGenomes-Tr:CCP44416,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FL8,NCBI_GP:CCP44416.1;Name=CCP44416.1;Note=Rv1651c%2C (MTCY06H11.16c)%2C len: 1011 aa. PE_PGRS30%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citations below)%2Csimilar to many e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kd protein (603 aa)%2C FASTA scores: opt: 1757%2C E(): 0%2C (50.8%25 identity in 714aa overlap). The transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al.%2C 2000).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS30;locus_tag=Rv1651c;product=PE-PGRS family protein PE_PGRS30;protein_id=CCP44416.1;transl_table=11
AL123456.3	EMBL	gene	1865576	1866634	.	+	.	ID=gene-Rv1652;Name=argC;gbkey=Gene;gene=argC;gene_biotype=protein_coding;locus_tag=Rv1652
AL123456.3	EMBL	CDS	1865576	1866634	.	+	0	ID=cds-CCP44417.1;Parent=gene-Rv1652;Dbxref=EnsemblGenomes-Gn:Rv1652,EnsemblGenomes-Tr:CCP44417,GOA:P9WPZ9,InterPro:IPR000534,InterPro:IPR000706,InterPro:IPR012280,InterPro:IPR016040,InterPro:IPR023013,PDB:2I3A,PDB:2I3G,PDB:2NQT,NCBI_GP:CCP44417.1;Name=CCP44417.1;Note=Rv1652%2C (MTCY06H11.17)%2C len: 352 aa. Probable argC%2CN-acetyl-gamma-glutamyl-phosphate reductase%2C similar to many e.g. ARGC_STRCL|P54896 from Streptomyces clavuligerus (340 aa)%2C FASTA scores: opt: 1119%2C E(): 0%2C (56.9%25 identity in 350 aa overlap)%3B etc. Belongs to the NAGSA dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argC;locus_tag=Rv1652;product=Probable N-acetyl-gamma-glutamyl-phoshate reductase ArgC;protein_id=CCP44417.1;transl_table=11
AL123456.3	EMBL	gene	1866631	1867845	.	+	.	ID=gene-Rv1653;Name=argJ;gbkey=Gene;gene=argJ;gene_biotype=protein_coding;locus_tag=Rv1653
AL123456.3	EMBL	CDS	1866631	1867845	.	+	0	ID=cds-CCP44418.1;Parent=gene-Rv1653;Dbxref=EnsemblGenomes-Gn:Rv1653,EnsemblGenomes-Tr:CCP44418,GOA:P9WPZ3,InterPro:IPR002813,InterPro:IPR016117,PDB:3IT4,PDB:3IT6,NCBI_GP:CCP44418.1;Name=CCP44418.1;Note=Rv1653%2C (MTCY06H11.18)%2C len: 404 aa. Probable argJ%2CGlutamate n-acetyltransferase%2C similar to ARGJ_BACSU|P36843 from Bacillus subtilis (406 aa)%2C fasta scores: opt: 727%2CE(): 0%2C (36.3%25 identity in 410 a a overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argJ;locus_tag=Rv1653;product=Probable glutamate N-acetyltransferase ArgJ;protein_id=CCP44418.1;transl_table=11
AL123456.3	EMBL	gene	1867842	1868726	.	+	.	ID=gene-Rv1654;Name=argB;gbkey=Gene;gene=argB;gene_biotype=protein_coding;locus_tag=Rv1654
AL123456.3	EMBL	CDS	1867842	1868726	.	+	0	ID=cds-CCP44419.1;Parent=gene-Rv1654;Dbxref=EnsemblGenomes-Gn:Rv1654,EnsemblGenomes-Tr:CCP44419,GOA:P9WQ01,InterPro:IPR001048,InterPro:IPR001057,InterPro:IPR004662,PDB:2AP9,NCBI_GP:CCP44419.1;Name=CCP44419.1;Note=Rv1654%2C (MTCY06H11.19)%2C len: 294 aa. Probable argB%2CAcetylglutamate kinase%2C similar to ARGB_CORGL|Q59281 (294 aa)%2C FASTA scores: opt: 1209%2C E(): 0%2C (64.4%25 identity in 270 aa overlap). Belongs to the acetylglutamate kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argB;locus_tag=Rv1654;product=Probable acetylglutamate kinase ArgB;protein_id=CCP44419.1;transl_table=11
AL123456.3	EMBL	gene	1868723	1869925	.	+	.	ID=gene-Rv1655;Name=argD;gbkey=Gene;gene=argD;gene_biotype=protein_coding;locus_tag=Rv1655
AL123456.3	EMBL	CDS	1868723	1869925	.	+	0	ID=cds-CCP44420.1;Parent=gene-Rv1655;Dbxref=EnsemblGenomes-Gn:Rv1655,EnsemblGenomes-Tr:CCP44420,GOA:P9WPZ7,InterPro:IPR004636,InterPro:IPR005814,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP44420.1;Name=CCP44420.1;Note=Rv1655%2C (MTCY06H11.20)%2C len: 400 aa. Probable argD%2CAcetylornithine aminotransferase%2C similar to ARGD_ECOLI|P18335 (406 aa)%2C FASTA scores: opt: 958%2C E(): 0%2C(38.6%25 identity in 404 aa overlap)%2C contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argD;inference=protein motif:PROSITE:PS00600;locus_tag=Rv1655;product=Probable acetylornithine aminotransferase ArgD;protein_id=CCP44420.1;transl_table=11
AL123456.3	EMBL	gene	1869922	1870845	.	+	.	ID=gene-Rv1656;Name=argF;gbkey=Gene;gene=argF;gene_biotype=protein_coding;gene_synonym=OTC;locus_tag=Rv1656
AL123456.3	EMBL	CDS	1869922	1870845	.	+	0	ID=cds-CCP44421.1;Parent=gene-Rv1656;Dbxref=EnsemblGenomes-Gn:Rv1656,EnsemblGenomes-Tr:CCP44421,GOA:P9WIT9,InterPro:IPR002292,InterPro:IPR006130,InterPro:IPR006131,InterPro:IPR006132,InterPro:IPR024904,PDB:2I6U,PDB:2P2G,NCBI_GP:CCP44421.1;Name=CCP44421.1;Note=Rv1656%2C (MTCY06H11.21)%2C len: 307 aa. Probable argF%2Cornithine carbamoyltransferase%2C anabolic (see citation below)%2C almost identical to OTCA_MYCBO|Q02095 ornithine carbamoyltransferase%2C anabolic from Mycobacterium bovis (307 aa)%2C FASTA scores: opt: 1980%2C E(): 0%2C (99.0%25 identity in 307 aa overlap)%3B contains PS00097 Aspartate and ornithine carbamoyltransferases signature. Belongs to the ATCases/OTCases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argF;inference=protein motif:PROSITE:PS00097;locus_tag=Rv1656;product=Probable ornithine carbamoyltransferase%2C anabolic ArgF;protein_id=CCP44421.1;transl_table=11
AL123456.3	EMBL	gene	1870842	1871354	.	+	.	ID=gene-Rv1657;Name=argR;gbkey=Gene;gene=argR;gene_biotype=protein_coding;gene_synonym=ahrC;locus_tag=Rv1657
AL123456.3	EMBL	CDS	1870842	1871354	.	+	0	ID=cds-CCP44422.1;Parent=gene-Rv1657;Dbxref=EnsemblGenomes-Gn:Rv1657,EnsemblGenomes-Tr:CCP44422,GOA:P9WPY9,InterPro:IPR001669,InterPro:IPR011991,InterPro:IPR020899,InterPro:IPR020900,InterPro:IPR024946,PDB:2ZFZ,PDB:3BUE,PDB:3CAG,PDB:3ERE,PDB:3FHZ,PDB:3LAJ,PDB:3LAP,NCBI_GP:CCP44422.1;Name=CCP44422.1;Note=Rv1657%2C (MTCY06H11.22)%2C len: 170 aa. Probable argR%2CArginine repressor (alternate gene name: ahrC). Similar to AHRC_BACSU|P17893 arginine hydroximate resistance protein from Bacillus subtilis (149 aa)%2C FASTA scores: opt: 283%2CE(): 1.8e-11%2C (34.5%25 identity in 142 aa overlap)%3B and ARGR_ECOLI|P15282 arginine repressor from Escherichia coli (156 aa)%2C FASTA scores: opt: 194%2C E(): 6.4e-06%2C (30.8%25 identity in 146 aa overlap). Belongs to the ArgR family.;gbkey=CDS;gene=argR;locus_tag=Rv1657;product=Probable arginine repressor ArgR (AHRC);protein_id=CCP44422.1;transl_table=11
AL123456.3	EMBL	gene	1871363	1872559	.	+	.	ID=gene-Rv1658;Name=argG;gbkey=Gene;gene=argG;gene_biotype=protein_coding;locus_tag=Rv1658
AL123456.3	EMBL	CDS	1871363	1872559	.	+	0	ID=cds-CCP44423.1;Parent=gene-Rv1658;Dbxref=EnsemblGenomes-Gn:Rv1658,EnsemblGenomes-Tr:CCP44423,GOA:P9WPW7,InterPro:IPR001518,InterPro:IPR014729,InterPro:IPR018223,InterPro:IPR023434,InterPro:IPR024074,NCBI_GP:CCP44423.1;Name=CCP44423.1;Note=Rv1658%2C (MTCY06H11.23)%2C len: 398 aa. Probable argG%2CArgininosuccinate synthase%2C similar to ASSY_STRCL|P50986 argininosuccinate synthase from Streptomyces clavuligerus (397 aa)%2C FASTA scores: opt: 1873%2C E(): 0%2C (67.8%25 identity in 397 aa overlap)%3B contains PS00564 Argininosuccinate synthase signature 1%2C PS00565 Argininosuccinate synthase signature 2. Belongs to the argininosuccinate synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argG;inference=protein motif:PROSITE:PS00565;locus_tag=Rv1658;product=Probable argininosuccinate synthase ArgG;protein_id=CCP44423.1;transl_table=11
AL123456.3	EMBL	gene	1872639	1874051	.	+	.	ID=gene-Rv1659;Name=argH;gbkey=Gene;gene=argH;gene_biotype=protein_coding;locus_tag=Rv1659
AL123456.3	EMBL	CDS	1872639	1874051	.	+	0	ID=cds-CCP44424.1;Parent=gene-Rv1659;Dbxref=EnsemblGenomes-Gn:Rv1659,EnsemblGenomes-Tr:CCP44424,GOA:P9WPY7,InterPro:IPR000362,InterPro:IPR008948,InterPro:IPR009049,InterPro:IPR020557,InterPro:IPR022761,InterPro:IPR024083,InterPro:IPR029419,NCBI_GP:CCP44424.1;Name=CCP44424.1;Note=Rv1659%2C (MTCY06H11.24)%2C len: 470 aa. Probable argH%2CArgininosuccinate lyase%2C similar to ARLY_ECOLI|P11447 argininosuccinate lyase from Escherichia coli (457 aa)%2CFASTA scores: opt: 1091%2C E(): 0%2C (42.5%25 identity in 461 aa overlap)%3B contains PS00017 ATP/GTP-binding site motif A%2CPS00163 Fumarate lyases signature. Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argH;inference=protein motif:PROSITE:PS00163;locus_tag=Rv1659;product=Probable argininosuccinate lyase ArgH;protein_id=CCP44424.1;transl_table=11
AL123456.3	EMBL	gene	1874160	1875221	.	+	.	ID=gene-Rv1660;Name=pks10;gbkey=Gene;gene=pks10;gene_biotype=protein_coding;locus_tag=Rv1660
AL123456.3	EMBL	CDS	1874160	1875221	.	+	0	ID=cds-CCP44425.1;Parent=gene-Rv1660;Dbxref=EnsemblGenomes-Gn:Rv1660,EnsemblGenomes-Tr:CCP44425,GOA:P9WPF5,InterPro:IPR001099,InterPro:IPR011141,InterPro:IPR012328,InterPro:IPR016038,InterPro:IPR016039,NCBI_GP:CCP44425.1;Name=CCP44425.1;Note=Rv1660%2C (MTCY06H11.25)%2C len: 353 aa. pks10%2C chalcone synthase%2C similar to BCSA_BACSU|P54157 putative chalcone synthase from B. subtilis (365 aa)%2C FASTA scores: opt: 701%2CE(): 0%2C (33.1%25 identity in 362 aa overlap). Also similar to M. tuberculosis Rv1665|pks11 polyketide synthase (chalcone synthase)%3B and Rv1372|pks18 polyketide synthase. Other upstream initiation sites are possible but homology suggests this start. Note pks10 has been shown to be involved in the biosynthesis of phthiocerol.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks10;locus_tag=Rv1660;product=Chalcone synthase Pks10;protein_id=CCP44425.1;transl_table=11
AL123456.3	EMBL	gene	1875304	1881684	.	+	.	ID=gene-Rv1661;Name=pks7;gbkey=Gene;gene=pks7;gene_biotype=protein_coding;locus_tag=Rv1661
AL123456.3	EMBL	CDS	1875304	1881684	.	+	0	ID=cds-CCP44426.1;Parent=gene-Rv1661;Dbxref=EnsemblGenomes-Gn:Rv1661,EnsemblGenomes-Tr:CCP44426,GOA:P94996,InterPro:IPR001227,InterPro:IPR002198,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR020807,InterPro:IPR020841,InterPro:IPR020842,InterPro:IPR020843,UniProtKB/TrEMBL:P94996,NCBI_GP:CCP44426.1;Name=CCP44426.1;Note=Rv1661%2C (MTCY06H11.26)%2C len: 2126 aa. Probable pks7%2Cpolyketide synthase%2C similar to many e.g. ERY2_SACER|Q03132 erythronolide synthase%2C modules 3 and 4 (3567 aa)%2C FASTA scores: E(): 0%2C (48.8%25 identity in 2131 aa overlap)%3B also similar to Mycobacterium tuberculosis pks12. Contains PS00606 Beta-ketoacyl synthases active site%2C PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks7;inference=protein motif:PROSITE:PS00606;locus_tag=Rv1661;product=Probable polyketide synthase Pks7;protein_id=CCP44426.1;transl_table=11
AL123456.3	EMBL	gene	1881704	1886512	.	+	.	ID=gene-Rv1662;Name=pks8;gbkey=Gene;gene=pks8;gene_biotype=protein_coding;locus_tag=Rv1662
AL123456.3	EMBL	CDS	1881704	1886512	.	+	0	ID=cds-CCP44427.1;Parent=gene-Rv1662;Dbxref=EnsemblGenomes-Gn:Rv1662,EnsemblGenomes-Tr:CCP44427,GOA:O65933,InterPro:IPR001227,InterPro:IPR002364,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR015083,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020807,InterPro:IPR020841,InterPro:IPR020843,UniProtKB/TrEMBL:O65933,NCBI_GP:CCP44427.1;Name=CCP44427.1;Note=Rv1662%2C (MTCY275.01-MTCY06H11.27)%2C len: 1602 aa. Probable pks8%2C polyketide synthase%2C similar to many polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide synthase%2C modules 3 and 4 from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa)%2C FASTA scores: opt: 3319%2C E(): 0%2C (45.8%25 identity in 1619 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks12. Contains PS00606 Beta-ketoacyl synthases active site and PS01162 Quinone oxidoreductase/zeta-crystallin signature. Note that the similarity extends into the downstream ORF Rv1663 (MTCY275.02)%2C and this could be accounted for by a frameshift%2C although the sequence has been checked and no discrepancy was found.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks8;inference=protein motif:PROSITE:PS01162;locus_tag=Rv1662;product=Probable polyketide synthase Pks8;protein_id=CCP44427.1;transl_table=11
AL123456.3	EMBL	gene	1886512	1888020	.	+	.	ID=gene-Rv1663;Name=pks17;gbkey=Gene;gene=pks17;gene_biotype=protein_coding;locus_tag=Rv1663
AL123456.3	EMBL	CDS	1886512	1888020	.	+	0	ID=cds-CCP44428.1;Parent=gene-Rv1663;Dbxref=EnsemblGenomes-Gn:Rv1663,EnsemblGenomes-Tr:CCP44428,GOA:O06585,InterPro:IPR002198,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR016040,InterPro:IPR020806,InterPro:IPR020842,UniProtKB/TrEMBL:O06585,NCBI_GP:CCP44428.1;Name=CCP44428.1;Note=Rv1663%2C (MTCY275.02)%2C len: 502 aa. Probable pks17%2Cpolyketide synthase%2C similar to other polyketide synthases e g. ERY2_SACER|Q03132 erythronolide synthase%2C modules 3 and 4 (3567 aa) from Saccharopolyspora erythraea (Streptomyces erythraeus)%2C FASTA scores: opt: 1207%2C E(): 0%2C(43.9%25 identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks7 and pks1. Note that the similarity extends into the upstream ORF Rv1662 (MTCY275.01) and this could be accounted for by a frameshift%2C although the sequence has been checked and no discrepancy was found. Contains PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks17;inference=protein motif:PROSITE:PS00012;locus_tag=Rv1663;product=Probable polyketide synthase Pks17;protein_id=CCP44428.1;transl_table=11
AL123456.3	EMBL	gene	1888026	1891079	.	+	.	ID=gene-Rv1664;Name=pks9;gbkey=Gene;gene=pks9;gene_biotype=protein_coding;locus_tag=Rv1664
AL123456.3	EMBL	CDS	1888026	1891079	.	+	0	ID=cds-CCP44429.1;Parent=gene-Rv1664;Dbxref=EnsemblGenomes-Gn:Rv1664,EnsemblGenomes-Tr:CCP44429,GOA:O06586,InterPro:IPR001227,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020801,InterPro:IPR020806,UniProtKB/TrEMBL:O06586,NCBI_GP:CCP44429.1;Name=CCP44429.1;Note=Rv1664%2C (MTCY275.03)%2C len: 1017 aa. Probable pks9%2Cpolyketide synthase%2C similar to OL56_STRAT|Q07017 oleandomycin polyketide synthase%2C modules 5 and 6 from Streptomyces antibioticus (3519 aa)%2C FASTA scores: opt: 1767%2C E(): 0%2C (41.6%25 identity in 919 aa overlap). Similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks6%2C pks8%2C etc. Contains PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks9;inference=protein motif:PROSITE:PS00012;locus_tag=Rv1664;product=Probable polyketide synthase Pks9;protein_id=CCP44429.1;transl_table=11
AL123456.3	EMBL	gene	1891226	1892287	.	+	.	ID=gene-Rv1665;Name=pks11;gbkey=Gene;gene=pks11;gene_biotype=protein_coding;locus_tag=Rv1665
AL123456.3	EMBL	CDS	1891226	1892287	.	+	0	ID=cds-CCP44430.1;Parent=gene-Rv1665;Dbxref=EnsemblGenomes-Gn:Rv1665,EnsemblGenomes-Tr:CCP44430,GOA:P9WPF3,InterPro:IPR001099,InterPro:IPR011141,InterPro:IPR012328,InterPro:IPR016038,InterPro:IPR016039,PDB:4JAO,PDB:4JAP,PDB:4JAQ,PDB:4JAR,PDB:4JAT,PDB:4JD3,NCBI_GP:CCP44430.1;Name=CCP44430.1;Note=Rv1665%2C (MTCY275.04-MTV047.01)%2C len: 353 aa. pks11%2Cchalcone synthase%2C some similarity to BCSA_BACSU|P54157 putative chalcone synthase from Bacillus subtilis (365 aa)%2CFASTA scores: opt: 615%2C E(): 6.2e-32%2C (33.4%25 identity in 308 aa overlap)%3B and to many plant chalcone synthases e.g. CHS_VIGUN|P51089 chalcone synthase (388 aa)%2C FASTA scores: opt: 391%2C E(): 7.8e-18%2C (27.2%25 identity in 349 aa overlap). Highly similar to upstream ORF Rv1660|MTCY06H11.25 pks10 (72.7%25 identity in 308 aa overlap)%3B and Rv1372 pks18.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks11;locus_tag=Rv1665;product=Chalcone synthase Pks11;protein_id=CCP44430.1;transl_table=11
AL123456.3	EMBL	gene	1892270	1893562	.	-	.	ID=gene-Rv1666c;Name=cyp139;gbkey=Gene;gene=cyp139;gene_biotype=protein_coding;locus_tag=Rv1666c
AL123456.3	EMBL	CDS	1892270	1893562	.	-	0	ID=cds-CCP44431.1;Parent=gene-Rv1666c;Dbxref=EnsemblGenomes-Gn:Rv1666c,EnsemblGenomes-Tr:CCP44431,GOA:P9WPM1,InterPro:IPR001128,InterPro:IPR002403,InterPro:IPR017972,NCBI_GP:CCP44431.1;Name=CCP44431.1;Note=Rv1666c%2C (MT1706%2C MTV047.02c)%2C len: 430 aa. Probable cyp139%2C cytochrome P450%2C similar to many e.g. U38537|APU38537_7 from Anabaena sp. (459 aa)%2C FASTA scores: opt: 516%2C E(): 1.7e-26%2C (25.8%25 identity in 418 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;gbkey=CDS;gene=cyp139;inference=protein motif:PROSITE:PS00086;locus_tag=Rv1666c;product=Probable cytochrome P450 139 Cyp139;protein_id=CCP44431.1;transl_table=11
AL123456.3	EMBL	gene	1893577	1894230	.	-	.	ID=gene-Rv1667c;Name=Rv1667c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1667c
AL123456.3	EMBL	CDS	1893577	1894230	.	-	0	ID=cds-CCP44432.1;Parent=gene-Rv1667c;Dbxref=EnsemblGenomes-Gn:Rv1667c,EnsemblGenomes-Tr:CCP44432,GOA:O53915,InterPro:IPR003439,InterPro:IPR027417,UniProtKB/TrEMBL:O53915,NCBI_GP:CCP44432.1;Name=CCP44432.1;Note=Rv1667c%2C (MTV047.03c)%2C len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below)%2C with similarity to C-terminal end of putative ABC transporters/ATP binding proteins%2C e.g. Z99108|BSUB0005_6 ABC transporter (ATP-binding protein) homolog yfmR from Bacillus subtilis (629 aa)%2C FASTA scores: opt: 411%2C E(): 6.9e-17%2C (37.8%25 identity in 217 aa overlap)%3B etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However%2C sequence has been checked and no errors found%2C also same sequence in M. tuberculosis CSU93 and Mycobacterium bovis.;gbkey=CDS;locus_tag=Rv1667c;product=Probable second part of macrolide-transport ATP-binding protein ABC transporter;protein_id=CCP44432.1;transl_table=11
AL123456.3	EMBL	gene	1894224	1895342	.	-	.	ID=gene-Rv1668c;Name=Rv1668c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1668c
AL123456.3	EMBL	CDS	1894224	1895342	.	-	0	ID=cds-CCP44433.1;Parent=gene-Rv1668c;Dbxref=EnsemblGenomes-Gn:Rv1668c,EnsemblGenomes-Tr:CCP44433,GOA:O53916,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O53916,NCBI_GP:CCP44433.1;Name=CCP44433.1;Note=Rv1668c%2C (MTV047.04c)%2C len: 372 aa. Probable first part of macrolide-transport ATP-binding protein ABC transporter (see citation below)%2C similar to many ATP-binding proteins ABC transporter e.g. X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX gene (481 aa)%2C FASTA scores: opt: 938%2C E(): 0%2C (45.6%25 identity in 353 aa overlap)%3B etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However%2C sequence has been checked and no error found%2C also same sequence in Mycobacterium tuberculosis CSU93 and Mycobacterium bovis. Contains PS00211 ABC transporters family signature and two times PS00017 ATP/GTP-binding site motif A. Belongs to the ATP-binding transport protein family (ABC transporters).;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1668c;product=Probable first part of macrolide-transport ATP-binding protein ABC transporter;protein_id=CCP44433.1;transl_table=11
AL123456.3	EMBL	gene	1895725	1896087	.	+	.	ID=gene-Rv1669;Name=Rv1669;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1669
AL123456.3	EMBL	CDS	1895725	1896087	.	+	0	ID=cds-CCP44434.1;Parent=gene-Rv1669;Dbxref=EnsemblGenomes-Gn:Rv1669,EnsemblGenomes-Tr:CCP44434,UniProtKB/TrEMBL:O86371,NCBI_GP:CCP44434.1;Name=CCP44434.1;Note=Rv1669%2C (MTV047.04B)%2C len: 120 aa. Hypothetical unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1669;product=Hypothetical protein;protein_id=CCP44434.1;transl_table=11
AL123456.3	EMBL	gene	1896120	1896467	.	+	.	ID=gene-Rv1670;Name=Rv1670;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1670
AL123456.3	EMBL	CDS	1896120	1896467	.	+	0	ID=cds-CCP44435.1;Parent=gene-Rv1670;Dbxref=EnsemblGenomes-Gn:Rv1670,EnsemblGenomes-Tr:CCP44435,InterPro:IPR007361,UniProtKB/TrEMBL:O53917,NCBI_GP:CCP44435.1;Name=CCP44435.1;Note=Rv1670%2C (MTV047.05)%2C len: 115 aa. Conserved hypothetical protein%2C highly similar to D90908|D90908_87 Hypothetical protein of Synechocystis sp. PCC6803 complete (94 aa)%2C FASTA scores opt: 378%2C E(): 3.5e-2%2C (55.2%25 identity in 96 aa overlap)%3B also shows some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. C-terminal region of O53404|Rv1056 (254 aa)%2C and P96817|Rv0140 (126 aa).;gbkey=CDS;locus_tag=Rv1670;product=Conserved hypothetical protein;protein_id=CCP44435.1;transl_table=11
AL123456.3	EMBL	gene	1896475	1896867	.	+	.	ID=gene-Rv1671;Name=Rv1671;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1671
AL123456.3	EMBL	CDS	1896475	1896867	.	+	0	ID=cds-CCP44436.1;Parent=gene-Rv1671;Dbxref=EnsemblGenomes-Gn:Rv1671,EnsemblGenomes-Tr:CCP44436,UniProtKB/TrEMBL:O53918,NCBI_GP:CCP44436.1;Name=CCP44436.1;Note=Rv1671%2C (MTV047.06)%2C len: 130 aa. Probable membrane protein. Weak similarity to mercuric transport proteins.;gbkey=CDS;locus_tag=Rv1671;product=Probable membrane protein;protein_id=CCP44436.1;transl_table=11
AL123456.3	EMBL	gene	1896876	1898207	.	-	.	ID=gene-Rv1672c;Name=Rv1672c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1672c
AL123456.3	EMBL	CDS	1896876	1898207	.	-	0	ID=cds-CCP44437.1;Parent=gene-Rv1672c;Dbxref=EnsemblGenomes-Gn:Rv1672c,EnsemblGenomes-Tr:CCP44437,GOA:O53919,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,UniProtKB/TrEMBL:O53919,NCBI_GP:CCP44437.1;Name=CCP44437.1;Note=Rv1672c%2C (MTV047.07c)%2C len: 443 aa. Probable conserved integral membrane transport protein%2C major facilitator superfamily%2C similar to several phthalate transporters or tartrate transporters e.g. U25634|AVU25634_2 Agrobacterium vitis plasmid pTrAB (433 aa)%2C FASTA scores: opt: 914%2C E(): 0%2C (37.1%25 identity in 426 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1672c;product=Probable conserved integral membrane transport protein;protein_id=CCP44437.1;transl_table=11
AL123456.3	EMBL	gene	1898300	1899232	.	-	.	ID=gene-Rv1673c;Name=Rv1673c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1673c
AL123456.3	EMBL	CDS	1898300	1899232	.	-	0	ID=cds-CCP44438.1;Parent=gene-Rv1673c;Dbxref=EnsemblGenomes-Gn:Rv1673c,EnsemblGenomes-Tr:CCP44438,InterPro:IPR002931,UniProtKB/TrEMBL:O53920,NCBI_GP:CCP44438.1;Name=CCP44438.1;Note=Rv1673c%2C (MTV047.08c)%2C len: 310 aa. Conserved hypothetical protein%2C shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa)%2C FASTA scores: E(): 8.3e-11%2C (26.1%25 identity in 330 aa overlap).;gbkey=CDS;locus_tag=Rv1673c;product=Conserved hypothetical protein;protein_id=CCP44438.1;transl_table=11
AL123456.3	EMBL	gene	1899260	1899916	.	-	.	ID=gene-Rv1674c;Name=Rv1674c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1674c
AL123456.3	EMBL	CDS	1899260	1899916	.	-	0	ID=cds-CCP44439.1;Parent=gene-Rv1674c;Dbxref=EnsemblGenomes-Gn:Rv1674c,EnsemblGenomes-Tr:CCP44439,GOA:O53921,InterPro:IPR001307,InterPro:IPR001763,InterPro:IPR001845,InterPro:IPR011991,UniProtKB/TrEMBL:O53921,NCBI_GP:CCP44439.1;Name=CCP44439.1;Note=Rv1674c%2C (MTV047.09c)%2C len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa)%2C FASTA scores: opt: 662%2C E(): 0%2C (50.0%25 identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa)%2C FASTA scores: opt: 579%2C E(): 0%2C (45.3%25 identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa)%2C FASTA scores: opt: 183%2C E(): 1.9e-06%2C(35.6%25 identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00380;locus_tag=Rv1674c;product=Probable transcriptional regulatory protein;protein_id=CCP44439.1;transl_table=11
AL123456.3	EMBL	gene	1900241	1900975	.	-	.	ID=gene-Rv1675c;Name=cmr;gbkey=Gene;gene=cmr;gene_biotype=protein_coding;locus_tag=Rv1675c
AL123456.3	EMBL	CDS	1900241	1900975	.	-	0	ID=cds-CCP44440.1;Parent=gene-Rv1675c;Dbxref=EnsemblGenomes-Gn:Rv1675c,EnsemblGenomes-Tr:CCP44440,GOA:P9WMH5,InterPro:IPR000595,InterPro:IPR001808,InterPro:IPR011991,InterPro:IPR012318,InterPro:IPR014710,InterPro:IPR018490,NCBI_GP:CCP44440.1;Name=CCP44440.1;Note=Rv1675c%2C (MTV047.10c)%2C len: 244 aa. Probable cmr%2CcAMP and macrophage regulator%2C transcriptional regulatory protein%2C weak similarity to D00496|LBATRP_7 trp operon from Lactobacillus casei (219 aa)%2C FASTA scores: opt: 172%2C E(): 0.00011%2C (26.9%25 identity in 186 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cmr;locus_tag=Rv1675c;product=Probable transcriptional regulatory protein Cmr;protein_id=CCP44440.1;transl_table=11
AL123456.3	EMBL	gene	1901047	1901751	.	+	.	ID=gene-Rv1676;Name=Rv1676;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1676
AL123456.3	EMBL	CDS	1901047	1901751	.	+	0	ID=cds-CCP44441.1;Parent=gene-Rv1676;Dbxref=EnsemblGenomes-Gn:Rv1676,EnsemblGenomes-Tr:CCP44441,GOA:O53923,InterPro:IPR000866,InterPro:IPR012336,UniProtKB/TrEMBL:O53923,NCBI_GP:CCP44441.1;Name=CCP44441.1;Note=Rv1676%2C (MTV047.11)%2C len: 234 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1676;product=Unknown protein;protein_id=CCP44441.1;transl_table=11
AL123456.3	EMBL	gene	1901748	1902296	.	+	.	ID=gene-Rv1677;Name=dsbF;gbkey=Gene;gene=dsbF;gene_biotype=protein_coding;locus_tag=Rv1677
AL123456.3	EMBL	CDS	1901748	1902296	.	+	0	ID=cds-CCP44442.1;Parent=gene-Rv1677;Dbxref=EnsemblGenomes-Gn:Rv1677,EnsemblGenomes-Tr:CCP44442,GOA:I6XYM2,InterPro:IPR012336,InterPro:IPR013740,InterPro:IPR017937,UniProtKB/TrEMBL:I6XYM2,NCBI_GP:CCP44442.1;Name=CCP44442.1;Note=Rv1677%2C (MTV047.12)%2C len: 182 aa. Probable dsbF%2Cconserved lipoprotein possibly involved in thiol:disulfide interchange. Highly similar to C-terminus of Z74024|MTCY274.09 mpt53 soluble secreted antigen precursor from Mycobacterium tuberculosis (173 aa)%2C FASTA scores: opt: 482%2C E(): 3.6e-23%2C (52.8%25 identity in 142 aa overlap) . Also some similarity to P52237|TIPB_PSEFL thiol:disulfide interchange protein TIPB precursor from Pseudomonas fluorescens (178 aa)%2C FASTA scores: opt: 190%2C E(): 4.4e-05%2C(28.5%25 identity in 151 aa overlap)%3B and P33926|DSBE_ECOLI thiol:disulfide interchange protein from Escherichia coli (185 aa)%2C FASTA scores: opt: 194%2C E(): 2.6e-05%2C (29.1%25 identity in 175 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00194 Thioredoxin family active site. Nucleotide position 1901816 in the genome sequence has been corrected%2C A:G resulting in Q23Q.;gbkey=CDS;gene=dsbF;inference=protein motif:PROSITE:PS00194;locus_tag=Rv1677;product=Probable conserved lipoprotein DsbF;protein_id=CCP44442.1;transl_table=11
AL123456.3	EMBL	gene	1902397	1903299	.	+	.	ID=gene-Rv1678;Name=Rv1678;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1678
AL123456.3	EMBL	CDS	1902397	1903299	.	+	0	ID=cds-CCP44443.1;Parent=gene-Rv1678;Dbxref=EnsemblGenomes-Gn:Rv1678,EnsemblGenomes-Tr:CCP44443,UniProtKB/TrEMBL:O53925,NCBI_GP:CCP44443.1;Name=CCP44443.1;Note=Rv1678%2C (MTV047.13)%2C len: 300 aa. Probable integral membrane protein.;gbkey=CDS;locus_tag=Rv1678;product=Probable integral membrane protein;protein_id=CCP44443.1;transl_table=11
AL123456.3	EMBL	gene	1903299	1904420	.	+	.	ID=gene-Rv1679;Name=fadE16;gbkey=Gene;gene=fadE16;gene_biotype=protein_coding;locus_tag=Rv1679
AL123456.3	EMBL	CDS	1903299	1904420	.	+	0	ID=cds-CCP44444.1;Parent=gene-Rv1679;Dbxref=EnsemblGenomes-Gn:Rv1679,EnsemblGenomes-Tr:CCP44444,GOA:O53926,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:O53926,NCBI_GP:CCP44444.1;Name=CCP44444.1;Note=Rv1679%2C (MTV047.14%2C MTCI125.01)%2C len: 373 aa. Possible fadE16%2C acyl-CoA dehydrogenase%2C similar to acyl/butyryl-CoA dehydrogenases e.g. NP_244665.1|NC_002570 acyl-CoA dehydrogenase from Bacillus halodurans (380 aa)%3B NP_000008.1|NM_000017 acyl-Coenzyme A dehydrogenase from Homo sapiens (412 aa)%3B Z99113|BSUB0010_119 from Bacillus subtilis (380 aa)%2C FASTA scores: opt: 439%2C E(): 3.4e-20%2C(29.6%25 identity in 287 aa overlap)%3B etc. Weakly similar to many dehydrogenases and to P31571|CAIA_ECOLI probable carnitine operon oxidoreductase from Escherichia coli (380 aa)%2C FASTA scores: opt: 109%2C E(): 0.0066%2C (28.6%25 identity in 98 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE16;locus_tag=Rv1679;product=Possible acyl-CoA dehydrogenase FadE16;protein_id=CCP44444.1;transl_table=11
AL123456.3	EMBL	gene	1904429	1905253	.	+	.	ID=gene-Rv1680;Name=Rv1680;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1680
AL123456.3	EMBL	CDS	1904429	1905253	.	+	0	ID=cds-CCP44445.1;Parent=gene-Rv1680;Dbxref=EnsemblGenomes-Gn:Rv1680,EnsemblGenomes-Tr:CCP44445,UniProtKB/TrEMBL:O33182,NCBI_GP:CCP44445.1;Name=CCP44445.1;Note=Rv1680%2C (MTCI125.02)%2C len: 274 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1680;product=Hypothetical protein;protein_id=CCP44445.1;transl_table=11
AL123456.3	EMBL	gene	1905250	1906242	.	+	.	ID=gene-Rv1681;Name=moeX;gbkey=Gene;gene=moeX;gene_biotype=protein_coding;locus_tag=Rv1681
AL123456.3	EMBL	CDS	1905250	1906242	.	+	0	ID=cds-CCP44446.1;Parent=gene-Rv1681;Dbxref=EnsemblGenomes-Gn:Rv1681,EnsemblGenomes-Tr:CCP44446,GOA:O33183,InterPro:IPR007197,InterPro:IPR013785,UniProtKB/TrEMBL:O33183,NCBI_GP:CCP44446.1;Name=CCP44446.1;Note=Rv1681%2C (MTCI125.03)%2C len: 330 aa. Possible moeX%2CMolybdopterin biosynthesis protein%2C has weak similarity to MOAA_ECOLI|P30745 molybdenum cofactor biosynthesis protein (329 aa)%2C FASTA scores: opt: 162%2C E(): 0.00081%2C (27.7%25 identity in 224 aa overlap) and to Rv3109|MTCY164.19 MoaA from Mycobacterium tuberculosis (28.5%25 identity in 165 aa overlap).;gbkey=CDS;gene=moeX;locus_tag=Rv1681;product=Possible molybdopterin biosynthesis protein MoeX;protein_id=CCP44446.1;transl_table=11
AL123456.3	EMBL	gene	1906403	1907320	.	+	.	ID=gene-Rv1682;Name=Rv1682;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1682
AL123456.3	EMBL	CDS	1906403	1907320	.	+	0	ID=cds-CCP44447.1;Parent=gene-Rv1682;Dbxref=EnsemblGenomes-Gn:Rv1682,EnsemblGenomes-Tr:CCP44447,InterPro:IPR007793,UniProtKB/TrEMBL:O33184,NCBI_GP:CCP44447.1;Name=CCP44447.1;Note=Rv1682%2C (MTCI125.04)%2C len: 305 aa. Probable coiled-coil structural protein%2C weakly similar to many paramyosins%2C kinesins and plectins e.g. MYSP_ONCVO|Q02171 paramyosin from onchocerca volvulus (879 aa)%2C fasta scores: opt: 180%2C E():2.6e-08%2C (24.4%25 identity in 234 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical coiled-coil proteins (wag31 antigen 84) Rv2145c and Rv2927c.;gbkey=CDS;locus_tag=Rv1682;product=Probable coiled-coil structural protein;protein_id=CCP44447.1;transl_table=11
AL123456.3	EMBL	repeat_region	1907460	1907515	.	+	.	ID=id-AL123456.3:1907460..1907515;Note=56 bp direct repeat 1%2C AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	1907516	1907571	.	+	.	ID=id-AL123456.3:1907516..1907571;Note=56 bp direct repeat 2%2C AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT;gbkey=repeat_region
AL123456.3	EMBL	gene	1907594	1910593	.	+	.	ID=gene-Rv1683;Name=Rv1683;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1683
AL123456.3	EMBL	CDS	1907594	1910593	.	+	0	ID=cds-CCP44448.1;Parent=gene-Rv1683;Dbxref=EnsemblGenomes-Gn:Rv1683,EnsemblGenomes-Tr:CCP44448,GOA:O33185,InterPro:IPR000873,InterPro:IPR029058,UniProtKB/TrEMBL:O33185,NCBI_GP:CCP44448.1;Name=CCP44448.1;Note=Rv1683%2C (MTCI125.05)%2C len: 999 aa. Possible bifunctional long-chain acyl-CoA synthase and lipase. Equivalent to Z95117|MLCB1351_21 possible long-chain acyl-CoA synthase from Mycobacterium leprae (1002 aa) (85.6%25 identity in 1002 aa overlap). Weakly similar to FATP_MOUSE|Q60714 long-chain fatty acid transport protein (646 aa)%2C fasta scores: opt: 331%2C E(): 5e-08%2C (24.8%25 identity in 630 aa overlap). Also similar to O35488|AF033031 Mouse very-long-chain acyl-CoA synthetase (620 aa)%2C fasta scores: opt: 435%2C E(): 2.2e-12%2C (24.8%25 identity in 545 aa overlap). Weakly similar to Mycobacterium tuberculosis protein MTCI364.18 (27.4%25 identity in 583 aa overlap). Contains PS00120 Lipases%2Cserine active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv1683;product=Possible bifunctional enzyme%3B long-chain acyl-CoA synthase and lipase.;protein_id=CCP44448.1;transl_table=11
AL123456.3	EMBL	gene	1910586	1910810	.	+	.	ID=gene-Rv1684;Name=Rv1684;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1684
AL123456.3	EMBL	CDS	1910586	1910810	.	+	0	ID=cds-CCP44449.1;Parent=gene-Rv1684;Dbxref=EnsemblGenomes-Gn:Rv1684,EnsemblGenomes-Tr:CCP44449,InterPro:IPR005651,UniProtKB/TrEMBL:O33186,NCBI_GP:CCP44449.1;Name=CCP44449.1;Note=Rv1684%2C (MTCI125.06)%2C len: 74 aa. Conserved hypothetical protein%2C similar to P75844|YCAR_ECOLI Protein YCAR from Escherichia coli (60 aa)%2C FASTA scores: opt: 108%2CE(): 0.00022%2C (39.0%25 identity in 59 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1684;product=Conserved hypothetical protein;protein_id=CCP44449.1;transl_table=11
AL123456.3	EMBL	gene	1910776	1911399	.	-	.	ID=gene-Rv1685c;Name=Rv1685c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1685c
AL123456.3	EMBL	CDS	1910776	1911399	.	-	0	ID=cds-CCP44450.1;Parent=gene-Rv1685c;Dbxref=EnsemblGenomes-Gn:Rv1685c,EnsemblGenomes-Tr:CCP44450,GOA:O33187,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O33187,NCBI_GP:CCP44450.1;Name=CCP44450.1;Note=Rv1685c%2C (MTCI125.07c)%2C len: 207 aa. Conserved hypothetical protein%2C some similarity to other Mycobacterium tuberculosis hypothetical regulatory proteins e.g. Q10774|Rv1556|YF56_MYCTU (202 aa)%2C FASTA scores: opt: 111%2C E(): 1.7e-05%2C (24.1%25 identity in 195 aa overlap)%3B and P95215|Rv0258c|MTCY06A4.02c (151 aa) FASTA scores: (32.9%25 identity in 140 aa overlap)%3B also similar to Q9X8G9|SCE7.13C|AL049819 putative Streptomyces coelicolor transcriptional regulator (204 aa)%2C FASTA scores: opt: 480%2CE(): 6.4e-25%2C (40.4%25 identity in 203 aa overlap).;gbkey=CDS;locus_tag=Rv1685c;product=Conserved hypothetical protein;protein_id=CCP44450.1;transl_table=11
AL123456.3	EMBL	gene	1911401	1912081	.	-	.	ID=gene-Rv1686c;Name=Rv1686c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1686c
AL123456.3	EMBL	CDS	1911401	1912081	.	-	0	ID=cds-CCP44451.1;Parent=gene-Rv1686c;Dbxref=EnsemblGenomes-Gn:Rv1686c,EnsemblGenomes-Tr:CCP44451,GOA:O33188,InterPro:IPR000412,InterPro:IPR004377,InterPro:IPR013525,UniProtKB/TrEMBL:O33188,NCBI_GP:CCP44451.1;Name=CCP44451.1;Note=Rv1686c%2C (MTCI125.08c)%2C len: 226 aa. Probable conserved integral membrane protein ABC transporter (see citation below)%2C similar to AL049819|SCE7.05 putative integral membrane protein from Streptomyces coelicolor (266 aa)%2C FASTA sacores: opt: 661%2C E(): 0%2C (45.1%25 identity in 226 aa overlap)%3B and Q53627|U43537 membrane protein involved in mithramycin resistance from streptomyces argillaceus (233 aa)%2C FASTA scores: opt: 222%2C E(): 5.4e-10%2C(28.7%25 identity in 216 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1686c;product=Probable conserved integral membrane protein ABC transporter;protein_id=CCP44451.1;transl_table=11
AL123456.3	EMBL	gene	1912153	1912920	.	-	.	ID=gene-Rv1687c;Name=Rv1687c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1687c
AL123456.3	EMBL	CDS	1912153	1912920	.	-	0	ID=cds-CCP44452.1;Parent=gene-Rv1687c;Dbxref=EnsemblGenomes-Gn:Rv1687c,EnsemblGenomes-Tr:CCP44452,GOA:O33189,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O33189,NCBI_GP:CCP44452.1;Name=CCP44452.1;Note=Rv1687c%2C (MTCI125.09c)%2C len: 255 aa. Probable conserved ATP-binding protein ABC transporter (see citation below)%2C similar to many ABC-type transporters e.g. P55476|NODI_RHISN nodulation ATP-binding protein I from Rhizobium sp. (343 aa)%2C FASTA scores: opt: 479%2C E(): 3.7e-23%2C (34.6%25 identity in 243 aa overlap)%3B etc. Also similar to many other Mycobacterium tuberculosis ABC-type transporters e.g. MTCY19H9.04 (34.5%25 identity in 238 aa overlap). Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters). Also contains PS00039 dead-box subfamily ATP-dependent helicases signature%2C though this may be spurious.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1687c;product=Probable conserved ATP-binding protein ABC transporter;protein_id=CCP44452.1;transl_table=11
AL123456.3	EMBL	gene	1912979	1913590	.	+	.	ID=gene-Rv1688;Name=mpg;gbkey=Gene;gene=mpg;gene_biotype=protein_coding;locus_tag=Rv1688
AL123456.3	EMBL	CDS	1912979	1913590	.	+	0	ID=cds-CCP44453.1;Parent=gene-Rv1688;Dbxref=EnsemblGenomes-Gn:Rv1688,EnsemblGenomes-Tr:CCP44453,GOA:P9WJP7,InterPro:IPR003180,InterPro:IPR011034,NCBI_GP:CCP44453.1;Name=CCP44453.1;Note=Rv1688%2C (MTCI125.10)%2C len: 203 aa. Possible mpg%2C3-methyladenine DNA glycosylase (see citation below)%2Csimilar to several eukaryotic 3-methylpurine DNA glycosylases and 3-methyladenine DNA glycosylases e.g. Q39147|X76169 3-methyladenine glycosylase from Arabidobsis thaliana (254 aa)%2C FASTA scores: opt: 297%2C E(): 8.3e-15%2C(31.8%25 identity in 198 aa overlap) and P29372|3MG_HUMAN dna-3-methyladenine glycosidase (298 aa)%2C FASTA scores: opt: 220%2C E(): 7.2e-05%2C (36.4%25 identity in 184 aa overlap). Belongs to the mpg family of DNA glycosylases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mpg;locus_tag=Rv1688;product=Possible 3-methyladenine DNA glycosylase Mpg;protein_id=CCP44453.1;transl_table=11
AL123456.3	EMBL	gene	1913602	1914876	.	+	.	ID=gene-Rv1689;Name=tyrS;gbkey=Gene;gene=tyrS;gene_biotype=protein_coding;locus_tag=Rv1689
AL123456.3	EMBL	CDS	1913602	1914876	.	+	0	ID=cds-CCP44454.1;Parent=gene-Rv1689;Dbxref=EnsemblGenomes-Gn:Rv1689,EnsemblGenomes-Tr:CCP44454,GOA:P9WFT1,InterPro:IPR001412,InterPro:IPR002305,InterPro:IPR002307,InterPro:IPR002942,InterPro:IPR014729,InterPro:IPR024088,InterPro:IPR024107,PDB:2JAN,NCBI_GP:CCP44454.1;Name=CCP44454.1;Note=Rv1689%2C (MTCI125.11)%2C len: 424 aa. Probable tyrS%2CTyrosyl-tRNA synthase%2C highly similar to many e.g. SYY_ECOLI|P00951 Escherichia coli (423 aa)%2C FASTA scores: opt: 1271%2C E(): 0%2C (47.3%25 identity in 419 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tyrS;inference=protein motif:PROSITE:PS00178;locus_tag=Rv1689;product=Probable tyrosyl-tRNA synthase TyrS (TYRRS);protein_id=CCP44454.1;transl_table=11
AL123456.3	EMBL	gene	1914962	1915190	.	-	.	ID=gene-G2;Name=G2;gbkey=Gene;gene=G2;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1914962	1915190	.	-	.	ID=rna-G2;Parent=gene-G2;Note=G2%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-end at position 1915028. Alternate 3'-end at position 1914977.;gbkey=ncRNA;gene=G2;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1914962	1915190	.	-	.	ID=exon-G2-1;Parent=rna-G2;Note=G2%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-end at position 1915028. Alternate 3'-end at position 1914977.;gbkey=ncRNA;gene=G2;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1915527	1915910	.	+	.	ID=gene-Rv1690;Name=lprJ;gbkey=Gene;gene=lprJ;gene_biotype=protein_coding;locus_tag=Rv1690
AL123456.3	EMBL	CDS	1915527	1915910	.	+	0	ID=cds-CCP44455.1;Parent=gene-Rv1690;Dbxref=EnsemblGenomes-Gn:Rv1690,EnsemblGenomes-Tr:CCP44455,GOA:O33192,InterPro:IPR007969,UniProtKB/TrEMBL:O33192,NCBI_GP:CCP44455.1;Name=CCP44455.1;Note=Rv1690%2C (MTCI125.12)%2C len: 127 aa. Probable lprJ%2Clipoprotein%3B contains possible signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Weakly similar to other Mycobacterium tuberculosis hypothetical proteins with conserved cysteines e.g. Rv1804c%2C Rv1810%2C Rv3354%2C etc;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprJ;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1690;product=Probable lipoprotein LprJ;protein_id=CCP44455.1;transl_table=11
AL123456.3	EMBL	gene	1915949	1916701	.	+	.	ID=gene-Rv1691;Name=Rv1691;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1691
AL123456.3	EMBL	CDS	1915949	1916701	.	+	0	ID=cds-CCP44456.1;Parent=gene-Rv1691;Dbxref=EnsemblGenomes-Gn:Rv1691,EnsemblGenomes-Tr:CCP44456,GOA:O33193,InterPro:IPR011990,UniProtKB/TrEMBL:O33193,NCBI_GP:CCP44456.1;Name=CCP44456.1;Note=Rv1691%2C MTCI125.13%2C len: 250 aa. Conserved hypothetical protein%2C similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa)%2CFASTA score: opt: 556%2C E(): 6.4e-27%2C (50.6%25 identity in 180 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1691;product=Conserved hypothetical protein;protein_id=CCP44456.1;transl_table=11
AL123456.3	EMBL	gene	1916698	1917759	.	+	.	ID=gene-Rv1692;Name=Rv1692;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1692
AL123456.3	EMBL	CDS	1916698	1917759	.	+	0	ID=cds-CCP44457.1;Parent=gene-Rv1692;Dbxref=EnsemblGenomes-Gn:Rv1692,EnsemblGenomes-Tr:CCP44457,GOA:O33194,InterPro:IPR006357,InterPro:IPR023214,InterPro:IPR023215,PDB:4I9G,UniProtKB/TrEMBL:O33194,NCBI_GP:CCP44457.1;Name=CCP44457.1;Note=Rv1692%2C (MTCI125.14)%2C len: 353 aa. Probable phosphatase%2C some similarity to others e.g. PNPP_SCHPO|Q00472 4-nitrophenylphosphatase (269 aa)%2C FASTA scores: opt: 214%2C E(): 1.3e-10%2C (29.5%25 identity in 241 aa overlap)%3B and to NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250 aa)%2C FASTA scores: opt: 314%2C E(): 9.8e-08%2C (28.2%25 identity in 245 aa overlap). Also similar to AL109848|SCI51.28 hypothetical protein from Streptomyces coelicolor (343 aa)%2C FASTA scores: opt: 768%2C E(): 0%2C (44.8%25 identity in 315 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1692;product=Probable phosphatase;protein_id=CCP44457.1;transl_table=11
AL123456.3	EMBL	gene	1917756	1917932	.	+	.	ID=gene-Rv1693;Name=Rv1693;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1693
AL123456.3	EMBL	CDS	1917756	1917932	.	+	0	ID=cds-CCP44458.1;Parent=gene-Rv1693;Dbxref=EnsemblGenomes-Gn:Rv1693,EnsemblGenomes-Tr:CCP44458,UniProtKB/TrEMBL:O33195,NCBI_GP:CCP44458.1;Name=CCP44458.1;Note=Rv1693%2C (MTCI125.15)%2C len: 58 aa. Conserved hypothetical protein%2C shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv1693;product=Conserved hypothetical protein;protein_id=CCP44458.1;transl_table=11
AL123456.3	EMBL	gene	1917940	1918746	.	+	.	ID=gene-Rv1694;Name=tlyA;gbkey=Gene;gene=tlyA;gene_biotype=protein_coding;locus_tag=Rv1694
AL123456.3	EMBL	CDS	1917940	1918746	.	+	0	ID=cds-CCP44459.1;Parent=gene-Rv1694;Dbxref=EnsemblGenomes-Gn:Rv1694,EnsemblGenomes-Tr:CCP44459,GOA:P9WJ63,InterPro:IPR002877,InterPro:IPR002942,InterPro:IPR004538,InterPro:IPR029063,NCBI_GP:CCP44459.1;Name=CCP44459.1;Note=Rv1694%2C (MTCI125.16)%2C len: 268 aa. TlyA%2C2'-O-methyltransferase%3B cytotoxin/haemolysin homologue (see citations below)%2C almost identical to NP_301968.1|NC_002677 cytotoxin/haemolysin homologue TlyA from Mycobacterium leprae (269 aa). TlyA homologues were also identified by PCR in Mycobacterium avium%2C Mycobacterium bovis BCG%2C but appeared absent in M. smegmatis%2C M. vaccae%2C M. kansasii%2C M. chelonae and M. phlei (see Wren et al.%2C 1998). Also highly similar to CAB83047.1|AJ271681 putative haemolysin from Mycobacterium ulcerans (281 aa)%3B and similar to HLYA_TREHY|Q06803 pore-forming haemolysin/cytotoxin virulence determinant from Treponema hyodysenteriae (240 aa)%2C FASTA scores: opt: 514%2C E():3e-30%2C (37.3%25 identity in 236 aa overlap).;gbkey=CDS;gene=tlyA;locus_tag=Rv1694;product=2'-O-methyltransferase TlyA;protein_id=CCP44459.1;transl_table=11
AL123456.3	EMBL	gene	1918746	1919669	.	+	.	ID=gene-Rv1695;Name=ppnK;gbkey=Gene;gene=ppnK;gene_biotype=protein_coding;locus_tag=Rv1695
AL123456.3	EMBL	CDS	1918746	1919669	.	+	0	ID=cds-CCP44460.1;Parent=gene-Rv1695;Dbxref=EnsemblGenomes-Gn:Rv1695,EnsemblGenomes-Tr:CCP44460,GOA:P9WHV7,InterPro:IPR002504,InterPro:IPR016064,InterPro:IPR017437,InterPro:IPR017438,PDB:1U0R,PDB:1U0T,PDB:1Y3H,PDB:1Y3I,NCBI_GP:CCP44460.1;Name=CCP44460.1;Note=Rv1695%2C (MTCI125.17)%2C len: 307 aa. PpnK%2C inorganic polyphosphate/ATP-NAD kinase (see citation below)%2Cequivalent to Q49897|MLC1351.13C|Z95117|PPNK_MYCLE inorganic polyphosphate/ATP-NAD kinase from Mycobacterium leprae (311 aa) (87.9%25 identity in 305 aa overlap). Also similar to many e.g. P37768|PPNK_ECOLI probable inorganic polyphosphate/ATP-NAD kinase (292 aa)%2C FASTA scores: opt: 384%2C E(): 1.7e-23%2C (33.5%25 identity in 233 aa overlap)%3B etc. Belongs to the NAD kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppnK;locus_tag=Rv1695;product=Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase);protein_id=CCP44460.1;transl_table=11
AL123456.3	EMBL	gene	1919683	1921446	.	+	.	ID=gene-Rv1696;Name=recN;gbkey=Gene;gene=recN;gene_biotype=protein_coding;locus_tag=Rv1696
AL123456.3	EMBL	CDS	1919683	1921446	.	+	0	ID=cds-CCP44461.1;Parent=gene-Rv1696;Dbxref=EnsemblGenomes-Gn:Rv1696,EnsemblGenomes-Tr:CCP44461,GOA:P9WHI7,InterPro:IPR003395,InterPro:IPR004604,InterPro:IPR027417,NCBI_GP:CCP44461.1;Name=CCP44461.1;Note=Rv1696%2C (MTCI125.18)%2C len: 587 aa. Probable recN%2CDNA repair protein (see citation below)%2C similar to many e.g. RECN_ECOLI|P05824 dna repair protein recN (553 aa)%2CFASTA scores: opt: 508%2C E(): 1.9e-33%2C (31.5%25 identity in 587 aa overlap). Equivalent to Z95117|MLCB1351_12 recN from Mycobacterium leprae (587 aa)%2C FASTA scores: (76.1%25 identit y in 589 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recN;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1696;product=Probable DNA repair protein RecN (recombination protein N);protein_id=CCP44461.1;transl_table=11
AL123456.3	EMBL	gene	1921542	1922723	.	+	.	ID=gene-Rv1697;Name=Rv1697;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1697
AL123456.3	EMBL	CDS	1921542	1922723	.	+	0	ID=cds-CCP44462.1;Parent=gene-Rv1697;Dbxref=EnsemblGenomes-Gn:Rv1697,EnsemblGenomes-Tr:CCP44462,GOA:O33198,InterPro:IPR007371,InterPro:IPR022215,UniProtKB/TrEMBL:O33198,NCBI_GP:CCP44462.1;Name=CCP44462.1;Note=Rv1697%2C (MTCI125.19)%2C len: 393 aa. Conserved hypothetical protein%2C highly similar to Q49895|MLC1351.11C|U00021 Hypothetical protein of Mycobacterium leprae from cosmid L247 (430 aa)%2C FASTA scores: opt: 2345%2C E(): 0%2C (90.6%25 identity in 393 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv1697;product=Conserved hypothetical protein;protein_id=CCP44462.1;transl_table=11
AL123456.3	EMBL	gene	1922745	1923689	.	+	.	ID=gene-Rv1698;Name=mctB;gbkey=Gene;gene=mctB;gene_biotype=protein_coding;locus_tag=Rv1698
AL123456.3	EMBL	CDS	1922745	1923689	.	+	0	ID=cds-CCP44463.1;Parent=gene-Rv1698;Dbxref=EnsemblGenomes-Gn:Rv1698,EnsemblGenomes-Tr:CCP44463,GOA:P9WJ83,InterPro:IPR021522,NCBI_GP:CCP44463.1;Name=CCP44463.1;Note=Rv1698%2C (MTCI125.20)%2C len: 314 aa. MctB%2Cmycobacterial copper transport protein B essential for Cu resistance and maintenance of low intracellular Cu levels (See Wolschendorf et al.%2C 2011). Outer membrane protein (See Siroy et al.%2C 2008) with predicted N-terminal signal sequence. Probable coiled-coil from aa 31 to 67. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=mctB;locus_tag=Rv1698;product=Outer membrane protein MctB;protein_id=CCP44463.1;transl_table=11
AL123456.3	EMBL	gene	1923829	1925589	.	+	.	ID=gene-Rv1699;Name=pyrG;gbkey=Gene;gene=pyrG;gene_biotype=protein_coding;locus_tag=Rv1699
AL123456.3	EMBL	CDS	1923829	1925589	.	+	0	ID=cds-CCP44464.1;Parent=gene-Rv1699;Dbxref=EnsemblGenomes-Gn:Rv1699,EnsemblGenomes-Tr:CCP44464,GOA:P9WHK7,InterPro:IPR004468,InterPro:IPR017456,InterPro:IPR017926,InterPro:IPR027417,InterPro:IPR029062,NCBI_GP:CCP44464.1;Name=CCP44464.1;Note=Rv1699%2C (MTCI125.21)%2C len: 586 aa. Probable pyrG%2CCTP synthase highly similar to many e.g. PYRG_ECOLI|P08398 ctp synthase from Escherichia coli (544 aa)%2C FASTA scores: opt: 1786%2C E():0%2C (51.8%25 identity in 548 aa overlap). Contains PS00442 Glutamine amidotransferases class-I active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrG;inference=protein motif:PROSITE:PS00442;locus_tag=Rv1699;product=Probable CTP synthase PyrG;protein_id=CCP44464.1;transl_table=11
AL123456.3	EMBL	gene	1925582	1926205	.	+	.	ID=gene-Rv1700;Name=Rv1700;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1700
AL123456.3	EMBL	CDS	1925582	1926205	.	+	0	ID=cds-CCP44465.1;Parent=gene-Rv1700;Dbxref=EnsemblGenomes-Gn:Rv1700,EnsemblGenomes-Tr:CCP44465,GOA:I6X235,InterPro:IPR000086,InterPro:IPR015797,UniProtKB/TrEMBL:I6X235,NCBI_GP:CCP44465.1;Name=CCP44465.1;Note=Rv1700%2C (MTCI125.22)%2C len: 207 aa. Nudix hydrolase%2Cequivalent to Q49891|MLC1351.08C|Z95117 Hypothetical protein from Mycobacterium leprae (177 aa)%2C FASTA scores: (66.7%25 identity in 171 aa overlap)%3B also similar to Q9S225|SCI51.15C|AL109848 Hypothetical protein from Streptomyces coelicolor (211 aa)%2C FASTA scores: opt: 508%2CE(): 1.2e-27%2C (43.1%25 identity in 197 aa overlap)%3B similar to P54570|ADPP_BACSU ADP-ribose pyrophosphatase (185 aa)%2CFASTA scores: opt: 313%2C E(): 1.1e-06%2C (42.7%25 identity in 124 aa overlap). Belongs to the family of Nudix hydrolases;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1700;product=NUDIX hydrolase;protein_id=CCP44465.1;transl_table=11
AL123456.3	EMBL	gene	1926202	1927137	.	+	.	ID=gene-Rv1701;Name=Rv1701;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1701
AL123456.3	EMBL	CDS	1926202	1927137	.	+	0	ID=cds-CCP44466.1;Parent=gene-Rv1701;Dbxref=EnsemblGenomes-Gn:Rv1701,EnsemblGenomes-Tr:CCP44466,GOA:P9WF33,InterPro:IPR002104,InterPro:IPR004107,InterPro:IPR011010,InterPro:IPR011932,InterPro:IPR013762,InterPro:IPR023009,InterPro:IPR023109,NCBI_GP:CCP44466.1;Name=CCP44466.1;Note=Rv1701%2C (MTCI125.23)%2C len: 311 aa. Probable integrase/recombinase%2C similar to many e.g. XERD_ECOLI|P21891 integrase/recombinase xerd (298 aa)%2CFASTA scores: opt: 583%2C E(): 0%2C (41.8%25 identity in 311 aa overlap). Also similar to other Mycobacterium tuberculosis integrase/recombinase proteins RV2894c|MTCY274.25c (43.1%25 identity in 304 aa overlap)%3B and Rv2646|MTCY441.16 phiRv2 integrase (31.1%25 identity in 161 aa overlap). Equivalent to Z95117|MLCB1351_7 from Mycobacterium leprae (316 aa) (85.4%25 identity in 316 aa overlap).;gbkey=CDS;locus_tag=Rv1701;product=Probable integrase/recombinase;protein_id=CCP44466.1;transl_table=11
AL123456.3	EMBL	gene	1927211	1928575	.	-	.	ID=gene-Rv1702c;Name=Rv1702c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1702c
AL123456.3	EMBL	CDS	1927211	1928575	.	-	0	ID=cds-CCP44467.1;Parent=gene-Rv1702c;Dbxref=EnsemblGenomes-Gn:Rv1702c,EnsemblGenomes-Tr:CCP44467,InterPro:IPR003615,InterPro:IPR003870,NCBI_GP:CCP44467.1;Name=CCP44467.1;Note=Rv1702c%2C (MTCI125.24c)%2C len: 454 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat. Similar to other hypothetical proteins inside REP13E12 elements (often in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317 aa)%2CFASTA scores: opt: 1284%2C E(): 0%2C (59.7%25 identity in 315 aa overlap)%3B and Rv1128c%2C Rv1945%2C Rv1148c%2C etc.;gbkey=CDS;locus_tag=Rv1702c;product=Conserved hypothetical protein;protein_id=CCP44467.1;transl_table=11
AL123456.3	EMBL	repeat_region	1927218	1928589	.	+	.	ID=id-AL123456.3:1927218..1928589;Note=REP-6%2C len: 1372 nt. REPI125%2C member of REP13E12 family.;gbkey=repeat_region
AL123456.3	EMBL	gene	1929131	1929721	.	-	.	ID=gene-Rv1703c;Name=Rv1703c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1703c
AL123456.3	EMBL	CDS	1929131	1929721	.	-	0	ID=cds-CCP44468.1;Parent=gene-Rv1703c;Dbxref=EnsemblGenomes-Gn:Rv1703c,EnsemblGenomes-Tr:CCP44468,GOA:L0TAD5,InterPro:IPR002935,InterPro:IPR025782,InterPro:IPR029063,UniProtKB/TrEMBL:L0TAD5,NCBI_GP:CCP44468.1;Name=CCP44468.1;Note=Rv1703c%2C (MTCI125.25c)%2C len: 196 aa. Probable catechol-o-methyltransferase%2C most similar to COMT_HUMAN|P21964 soluble form of mammalian catechol o-methyltransferase (271 aa)%2C FASTA scores: opt: 405%2C E(): 7.8e-29%2C (38.9%25 identity in 190 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical methyltransferases Rv0187%2C Rv1220c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1703c;product=Probable catechol-O-methyltransferase;protein_id=CCP44468.1;transl_table=11
AL123456.3	EMBL	gene	1929786	1931456	.	-	.	ID=gene-Rv1704c;Name=cycA;gbkey=Gene;gene=cycA;gene_biotype=protein_coding;locus_tag=Rv1704c
AL123456.3	EMBL	CDS	1929786	1931456	.	-	0	ID=cds-CCP44469.1;Parent=gene-Rv1704c;Dbxref=EnsemblGenomes-Gn:Rv1704c,EnsemblGenomes-Tr:CCP44469,GOA:O33203,InterPro:IPR002293,InterPro:IPR004840,InterPro:IPR004841,UniProtKB/TrEMBL:O33203,NCBI_GP:CCP44469.1;Name=CCP44469.1;Note=Rv1704c%2C (MTCI125.26c)%2C len: 556 aa. Probable cycA%2CD-serine/D-alanine/glycine transporter%2C highly similar to P39312|CYCA_ECOLI d-serine/d-alanine/glycine transporter from Escherichia coli (470 aa)%2C FASTA scores: opt: 1906%2CE(): 0%2C (59.3%25 identity in 459 aa overlap)%3B etc. Also similar to other Mycobacterium tuberculosis amino-acid permeases e.g. Rv2127%2C Rv0346c%2C etc. Contains PS00218 amino acid permeases signature. Belongs to the amino acid permease family (APC family).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cycA;inference=protein motif:PROSITE:PS00218;locus_tag=Rv1704c;product=Probable D-serine/alanine/glycine transporter protein CycA;protein_id=CCP44469.1;transl_table=11
AL123456.3	EMBL	gene	1931497	1932654	.	-	.	ID=gene-Rv1705c;Name=PPE22;gbkey=Gene;gene=PPE22;gene_biotype=protein_coding;locus_tag=Rv1705c
AL123456.3	EMBL	CDS	1931497	1932654	.	-	0	ID=cds-CCP44470.1;Parent=gene-Rv1705c;Dbxref=EnsemblGenomes-Gn:Rv1705c,EnsemblGenomes-Tr:CCP44470,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44470.1;Name=CCP44470.1;Note=Rv1705c%2C (MTCI125.27c)%2C len: 385 aa. PPE22%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.2 3 (404 aa)%2C fasta scores: opt: 819%2C E(): 0%2C (46.2%25 identity in 413 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE22;locus_tag=Rv1705c;product=PPE family protein PPE22;protein_id=CCP44470.1;transl_table=11
AL123456.3	EMBL	gene	1932694	1933878	.	-	.	ID=gene-Rv1706c;Name=PPE23;gbkey=Gene;gene=PPE23;gene_biotype=protein_coding;locus_tag=Rv1706c
AL123456.3	EMBL	CDS	1932694	1933878	.	-	0	ID=cds-CCP44471.1;Parent=gene-Rv1706c;Dbxref=EnsemblGenomes-Gn:Rv1706c,EnsemblGenomes-Tr:CCP44471,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44471.1;Name=CCP44471.1;Note=Rv1706c%2C (MTCI125.28c)%2C len: 394 aa. PPE23%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa)%2C fasta scores: opt: 841%2C E(): 3.9e-31%2C (46.8%25 identity in 408 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE23;locus_tag=Rv1706c;product=PPE family protein PPE23;protein_id=CCP44471.1;transl_table=11
AL123456.3	EMBL	gene	1934482	1934649	.	-	.	ID=gene-Rv1706A;Name=Rv1706A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1706A
AL123456.3	EMBL	CDS	1934482	1934649	.	-	0	ID=cds-CCP44472.1;Parent=gene-Rv1706A;Dbxref=EnsemblGenomes-Gn:Rv1706A,EnsemblGenomes-Tr:CCP44472,UniProtKB/TrEMBL:Q79FL4,NCBI_GP:CCP44472.1;Name=CCP44472.1;Note=Rv1706A%2C len: 55 aa. Conserved hypothetical protein%2Csimilar to part of several probable export proteins e.g. Rv0783c|Z80226_28 from Mycobacterium tuberculosis (540 aa)%2CFASTA scores: opt: 125%2C E(): 0.011%2C (52.85%25 identity in 53 aa overlap). Size difference suggests possible gene fragment.;gbkey=CDS;locus_tag=Rv1706A;product=Conserved hypothetical protein;protein_id=CCP44472.1;transl_table=11
AL123456.3	EMBL	gene	1934882	1936342	.	+	.	ID=gene-Rv1707;Name=Rv1707;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1707
AL123456.3	EMBL	CDS	1934882	1936342	.	+	0	ID=cds-CCP44473.1;Parent=gene-Rv1707;Dbxref=EnsemblGenomes-Gn:Rv1707,EnsemblGenomes-Tr:CCP44473,GOA:O33206,InterPro:IPR002645,InterPro:IPR011547,UniProtKB/TrEMBL:O33206,NCBI_GP:CCP44473.1;Name=CCP44473.1;Note=Rv1707%2C (MTCI125.29)%2C len: 486 aa. Probable conserved transmembrane protein%2C possibly involved in transport of sulfate%2C similar to several hypothetical proteins belonging to the sulfate permease family e.g. P40877|YCHM_ECOLI hypothetical 58.4 kDa protein in pth-prsa intergenic region from Escherichia coli (550 aa)%2C FASTA scores: opt: 486%2C E(): 0%2C (33.1%25 identity in 492 aa overlap). Also similar to many other Mycobacterium tuberculosis membrane proteins e.g. Rv3273%2C Rv1739c. Seems to belong to the SulP family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1707;product=Probable conserved transmembrane protein;protein_id=CCP44473.1;transl_table=11
AL123456.3	EMBL	gene	1936360	1937316	.	+	.	ID=gene-Rv1708;Name=Rv1708;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1708
AL123456.3	EMBL	CDS	1936360	1937316	.	+	0	ID=cds-CCP44474.1;Parent=gene-Rv1708;Dbxref=EnsemblGenomes-Gn:Rv1708,EnsemblGenomes-Tr:CCP44474,GOA:P9WLT1,InterPro:IPR002586,InterPro:IPR027417,NCBI_GP:CCP44474.1;Name=CCP44474.1;Note=Rv1708%2C (MTCI125.30)%2C len: 318 aa. Putative initiation inhibitor protein%2C a soj-related protein probably involved in cell process%2C highly similar to many sporulation initiation inhibitor proteins soj e.g. P37522|SOJ_BACSU Soj protein from Bacillus subtilis (253 aa)%2C FASTA scores: opt: 745%2C E(): 0%2C (46.0%25 identity in 248 aa overlap)%2C and more weakly to various repA/para/incC proteins from various organisms e.g. Y4CK_RHISN|P55393 putative replication protein A from Rhizobium sp. (407 aa)%2CFASTA scores: opt: 205%2C E(): 4e-13%2C (29.0%25 identity in 252 aa overlap). Also similar to Mycobacterium tuberculosis hyothetical proteins Rv3213c and Rv3918c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1708;product=Putative initiation inhibitor protein;protein_id=CCP44474.1;transl_table=11
AL123456.3	EMBL	gene	1937313	1938149	.	+	.	ID=gene-Rv1709;Name=scpA;gbkey=Gene;gene=scpA;gene_biotype=protein_coding;locus_tag=Rv1709
AL123456.3	EMBL	CDS	1937313	1938149	.	+	0	ID=cds-CCP44475.1;Parent=gene-Rv1709;Dbxref=EnsemblGenomes-Gn:Rv1709,EnsemblGenomes-Tr:CCP44475,InterPro:IPR003768,UniProtKB/TrEMBL:O33208,NCBI_GP:CCP44475.1;Name=CCP44475.1;Note=Rv1709%2C (MTCI125.31)%2C len: 278 aa. Possible scpA%2Csegregation and condensation protein%2C similar to e.g. P35154|YPUG_BACSU from Bacillus subtilis (251 aa)%2C FASTA scores: opt: 271%2C E(): 8.2e-10%2C (27.0%25 identity in 248 aa overlap)%3B Q9S230|SCI51.10C|AL109848 from Streptomyces coelicolor (264 aa)%2C FASTA scores: opt: 855%2C E(): 0%2C (56.8%25 identity in 257 aa overlap). Equivalent to Q49888|MLC1351.05C|Z95117 from Mycobacterium leprae (268 aa)%2C FASTA scores: (78.9%25 identity in 251 aa overlap).;gbkey=CDS;gene=scpA;locus_tag=Rv1709;product=Possible segregation and condensation protein ScpA;protein_id=CCP44475.1;transl_table=11
AL123456.3	EMBL	repeat_region	1938093	1938145	.	+	.	ID=id-Rv1709;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region;gene=scpA;locus_tag=Rv1709
AL123456.3	EMBL	gene	1938146	1938841	.	+	.	ID=gene-Rv1710;Name=scpB;gbkey=Gene;gene=scpB;gene_biotype=protein_coding;locus_tag=Rv1710
AL123456.3	EMBL	CDS	1938146	1938841	.	+	0	ID=cds-CCP44476.1;Parent=gene-Rv1710;Dbxref=EnsemblGenomes-Gn:Rv1710,EnsemblGenomes-Tr:CCP44476,GOA:I6XCB2,InterPro:IPR005234,InterPro:IPR011991,UniProtKB/TrEMBL:I6XCB2,NCBI_GP:CCP44476.1;Name=CCP44476.1;Note=Rv1710%2C (MTCI125.32)%2C len: 231 aa. Possible scpB%2Csegregation and condensation protein%2C similar to several hypothetical proteins e.g. P35155|YPUH_BACSU from Bacillus subtilis (197 aa)%2C FASTA scores: opt: 339%2C E(): 1.3e-09%2C(36.0%25 identity in 186 aa overlap)%3B Q9S231|SCI51.09C|AL109848 from Streptomyces coelicolor (223 aa)%2C FASTA scores: opt: 626%2C E(): 0%2C (51.0%25 identity in 192 aa overlap). Equivalent to O05669|MLC1351.04C|Z95117 Hypothetical protein from Mycobacterium leprae (231 aa)%2CFASTA scores: (77.9%25 identity in 231 aa overlap).;gbkey=CDS;gene=scpB;locus_tag=Rv1710;product=Possible segregation and condensation protein ScpB;protein_id=CCP44476.1;transl_table=11
AL123456.3	EMBL	gene	1938838	1939602	.	+	.	ID=gene-Rv1711;Name=Rv1711;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1711
AL123456.3	EMBL	CDS	1938838	1939602	.	+	0	ID=cds-CCP44477.1;Parent=gene-Rv1711;Dbxref=EnsemblGenomes-Gn:Rv1711,EnsemblGenomes-Tr:CCP44477,GOA:P9WHQ1,InterPro:IPR000748,InterPro:IPR002942,InterPro:IPR006145,InterPro:IPR018496,InterPro:IPR020103,NCBI_GP:CCP44477.1;Name=CCP44477.1;Note=Rv1711%2C (MTCI125.33)%2C len: 254 aa. Conserved hypothetical protein%2C highly similar to a large family of hypothetical proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 aa)%2C FASTA scores: opt: 496%2C E(): 1.1e-29%2C (41.6%25 identity in 250 aa overlap)%3B 9S232|SCI51.08C|AL109848 putative pseudouridine synthase from Streptomyces coelicolor (371 aa)%2C FASTA scores: opt: 818%2C E(): 0%2C (53.1%25 identity in 245 aa overlap). Equivalent to O05668|MLCB1351.03C|Z95117 Hypothetical protein from Mycobacterium leprae (256 aa)%2C (80.5%25 identity in 256 aa overlap). Contains PS01149 Hypothetical yciL/yejD/yjbC family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01149;locus_tag=Rv1711;product=Conserved hypothetical protein;protein_id=CCP44477.1;transl_table=11
AL123456.3	EMBL	gene	1939599	1940291	.	+	.	ID=gene-Rv1712;Name=cmk;gbkey=Gene;gene=cmk;gene_biotype=protein_coding;locus_tag=Rv1712
AL123456.3	EMBL	CDS	1939599	1940291	.	+	0	ID=cds-CCP44478.1;Parent=gene-Rv1712;Dbxref=EnsemblGenomes-Gn:Rv1712,EnsemblGenomes-Tr:CCP44478,GOA:P9WPA9,InterPro:IPR003136,InterPro:IPR011994,InterPro:IPR027417,NCBI_GP:CCP44478.1;Name=CCP44478.1;Note=Rv1712%2C (MTCI125.34)%2C len: 230 aa. cmk%2C cytidylate kinase%2C highly similar to many e.g. KCY_ECOLI|P23863 cytidylate kinase from Escherichia coli (227 aa)%2C FASTA scores: opt: 534%2C E (): 0%2C (40.3%25 identity in 221 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Equivalent to Z95117|MLCB1351_2 from Mycobacterium leprae (223 aa) (73.5%25 identity in 226 aa overlap). Belongs to the cytidylate kinase family%2Csubfamily 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cmk;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1712;product=Cytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck);protein_id=CCP44478.1;transl_table=11
AL123456.3	EMBL	gene	1940288	1941679	.	+	.	ID=gene-Rv1713;Name=engA;gbkey=Gene;gene=engA;gene_biotype=protein_coding;locus_tag=Rv1713
AL123456.3	EMBL	CDS	1940288	1941679	.	+	0	ID=cds-CCP44479.1;Parent=gene-Rv1713;Dbxref=EnsemblGenomes-Gn:Rv1713,EnsemblGenomes-Tr:CCP44479,GOA:P9WNL3,InterPro:IPR003593,InterPro:IPR005225,InterPro:IPR006073,InterPro:IPR015946,InterPro:IPR016484,InterPro:IPR027417,NCBI_GP:CCP44479.1;Name=CCP44479.1;Note=Rv1713%2C (MTCI125.35)%2C len: 463 aa. Probable engA%2CGTP-binding protein. Equivalent to Q49884|MLCB1351.01|U00021_5 probable GTP-binding protein ENGA from Mycobacterium leprae (461 aa)%2C (88.6%25 identity in 463 aa overlap). And similar to many e.g. P50743|ENGA_BACSU probable GTP-binding protein ENGA from Bacillus subtilus (436 aa)%2C FASTA scores: opt: 1077%2C E(): 0%2C (40.6%25 identity in 434 aa overlap). Contains two PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the era/TRME family of GTP-binding proteins. ENGA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=engA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1713;product=Probable GTP-binding protein EngA;protein_id=CCP44479.1;transl_table=11
AL123456.3	EMBL	gene	1941853	1942665	.	+	.	ID=gene-Rv1714;Name=Rv1714;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1714
AL123456.3	EMBL	CDS	1941853	1942665	.	+	0	ID=cds-CCP44480.1;Parent=gene-Rv1714;Dbxref=EnsemblGenomes-Gn:Rv1714,EnsemblGenomes-Tr:CCP44480,GOA:P9WGQ3,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,NCBI_GP:CCP44480.1;Name=CCP44480.1;Note=Rv1714%2C (MTV048.01)%2C len: 270 aa. Probable oxidoreductase similar to many e.g. AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa)%2C FASTA scores: opt: 578%2C E(): 3.3e-31%2C (38.9%25 identity in 265 aa overlap). Also similar to several other M. tuberculosis oxidoreductases e.g. Rv1544%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1714;product=Probable oxidoreductase;protein_id=CCP44480.1;transl_table=11
AL123456.3	EMBL	gene	1942659	1943573	.	+	.	ID=gene-Rv1715;Name=fadB3;gbkey=Gene;gene=fadB3;gene_biotype=protein_coding;locus_tag=Rv1715
AL123456.3	EMBL	CDS	1942659	1943573	.	+	0	ID=cds-CCP44481.1;Parent=gene-Rv1715;Dbxref=EnsemblGenomes-Gn:Rv1715,EnsemblGenomes-Tr:CCP44481,GOA:L7N688,InterPro:IPR006108,InterPro:IPR006176,InterPro:IPR008927,InterPro:IPR013328,InterPro:IPR016040,InterPro:IPR022694,UniProtKB/TrEMBL:L7N688,NCBI_GP:CCP44481.1;Name=CCP44481.1;Note=Rv1715%2C (MTV048.02)%2C len: 304 aa. Probable fadB3%2C3-hydroxybutyryl-CoA dehydrogenase%2C highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa)%3B NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa)%3B P45856|HBD_BACSU probable 3-hydroxybutyryl-CoA dehydrogenase from Bacillus subtilis (287 aa)%2C FASTA scores: opt: 488%2C E(): 1.5e-24%2C (38.7%25 identity in 279 aa overlap)%3B etc. Could belong to the 3-hydroxyacyl-CoA dehydrogenase family.;gbkey=CDS;gene=fadB3;locus_tag=Rv1715;product=Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD);protein_id=CCP44481.1;transl_table=11
AL123456.3	EMBL	gene	1943576	1944406	.	+	.	ID=gene-Rv1716;Name=Rv1716;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1716
AL123456.3	EMBL	CDS	1943576	1944406	.	+	0	ID=cds-CCP44482.1;Parent=gene-Rv1716;Dbxref=EnsemblGenomes-Gn:Rv1716,EnsemblGenomes-Tr:CCP44482,GOA:O53929,InterPro:IPR007325,UniProtKB/TrEMBL:O53929,NCBI_GP:CCP44482.1;Name=CCP44482.1;Note=Rv1716%2C (MTV048.03%2CMTCY04C12.01)%2C len: 276 aa. Conserved hypothetical protein%2C shows high similarity with AF1200|O29068|AE001021_11A conserved protein of Archaeoglobus fulgidus%2C gp fulgidus section 7 (278 aa)%2CFASTA scores: E(): 0%2C (61.8%25 identity in 251 a a overlap)%3B also weak similarity to several polyketide cyclases e.g. O68500|AF048833|DPSY from Streptomyces peucetius (272 aa)%2CFASTA scores: opt: 194%2C E(): 1.7e-05%2C (29.6%25 identity in 223 aa overlap).;gbkey=CDS;locus_tag=Rv1716;product=Conserved hypothetical protein;protein_id=CCP44482.1;transl_table=11
AL123456.3	EMBL	gene	1944406	1944756	.	+	.	ID=gene-Rv1717;Name=Rv1717;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1717
AL123456.3	EMBL	CDS	1944406	1944756	.	+	0	ID=cds-CCP44483.1;Parent=gene-Rv1717;Dbxref=EnsemblGenomes-Gn:Rv1717,EnsemblGenomes-Tr:CCP44483,InterPro:IPR011051,InterPro:IPR013096,InterPro:IPR014710,UniProtKB/TrEMBL:O86372,NCBI_GP:CCP44483.1;Name=CCP44483.1;Note=Rv1717%2C (MTCY04C12.02)%2C len: 116 aa. Conserved hypothetical protein%2C similar to O29060|AF1208|AE001021 Hypothetical protein from Arecheoglobus fulgidus (114 aa)%2CFASTA scores: opt: 254%2C E(): 3.3e-09%2C (37.7%25 identity in 114 aa overlap).;gbkey=CDS;locus_tag=Rv1717;product=Conserved hypothetical protein;protein_id=CCP44483.1;transl_table=11
AL123456.3	EMBL	repeat_region	1944756	1944808	.	+	.	ID=id-AL123456.3:1944756..1944808;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	1944809	1945627	.	+	.	ID=gene-Rv1718;Name=Rv1718;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1718
AL123456.3	EMBL	CDS	1944809	1945627	.	+	0	ID=cds-CCP44484.1;Parent=gene-Rv1718;Dbxref=EnsemblGenomes-Gn:Rv1718,EnsemblGenomes-Tr:CCP44484,GOA:P71976,InterPro:IPR008567,InterPro:IPR013785,UniProtKB/TrEMBL:P71976,NCBI_GP:CCP44484.1;Name=CCP44484.1;Note=Rv1718%2C (MTCY04C12.03)%2C len: 272 aa. Conserved hypothetical protein%2C similar to O29058|AF1210|AE001021 Hypothetical protein from Archeoglobus (313 aa)%2C FASTA scores: opt: 301%2C E(): 8e-23%2C (31.6%25 identity in 301 aa overlap).;gbkey=CDS;locus_tag=Rv1718;product=Conserved hypothetical protein;protein_id=CCP44484.1;transl_table=11
AL123456.3	EMBL	gene	1945641	1946420	.	+	.	ID=gene-Rv1719;Name=Rv1719;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1719
AL123456.3	EMBL	CDS	1945641	1946420	.	+	0	ID=cds-CCP44485.1;Parent=gene-Rv1719;Dbxref=EnsemblGenomes-Gn:Rv1719,EnsemblGenomes-Tr:CCP44485,GOA:P71977,InterPro:IPR001808,InterPro:IPR005471,InterPro:IPR011991,InterPro:IPR014757,InterPro:IPR029016,UniProtKB/TrEMBL:P71977,NCBI_GP:CCP44485.1;Name=CCP44485.1;Note=Rv1719%2C (MTCY04C12.04)%2C len: 259 aa. Probable transcriptional regulatory protein%2C similar to YIAJ_ECOLI|P37671 hypothetical transcriptional regulator from Escherichia coli (282 aa)%2C FASTA scores: opt: 353%2CE(): 3.2e-15%2C (31.1%25 identity in 235 aa overlap). Similar to Mycobacterium tuberculosis hypothetical IclR-family transcriptional regulators Rv2989%2C Rv1773c. Helix-turn-helix motif from aa 34-55 (+6.94 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1719;product=Probable transcriptional regulatory protein;protein_id=CCP44485.1;transl_table=11
AL123456.3	EMBL	gene	1946613	1946686	.	+	.	ID=gene-proT;Name=proT;gbkey=Gene;gene=proT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	1946613	1946686	.	+	.	ID=rna-proT;Parent=gene-proT;Note=codon recognized: CCC%3B proT%2C tRNA-Pro%2C anticodon ggg%2C length %3D 74;anticodon=(pos:1946647..1946649);gbkey=tRNA;gene=proT;product=tRNA-Pro
AL123456.3	EMBL	exon	1946613	1946686	.	+	.	ID=exon-proT-1;Parent=rna-proT;Note=codon recognized: CCC%3B proT%2C tRNA-Pro%2C anticodon ggg%2C length %3D 74;anticodon=(pos:1946647..1946649);gbkey=tRNA;gene=proT;product=tRNA-Pro
AL123456.3	EMBL	gene	1947030	1947419	.	-	.	ID=gene-Rv1720c;Name=vapC12;gbkey=Gene;gene=vapC12;gene_biotype=protein_coding;locus_tag=Rv1720c
AL123456.3	EMBL	CDS	1947030	1947419	.	-	0	ID=cds-CCP44486.1;Parent=gene-Rv1720c;Dbxref=EnsemblGenomes-Gn:Rv1720c,EnsemblGenomes-Tr:CCP44486,GOA:P9WFA3,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44486.1;Name=CCP44486.1;Note=Rv1720c%2C (MTCY04C12.05c)%2C len: 129 aa. Possible vapC12%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv1721c%2C contains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53610|Rv0065|MTV030.08 (133 aa)%2C FASTA scores: E(): 1.5e-10%2C (39.1%25 identity in 128 aa overlap)%3B P71550|Rv0960|MTCY10D7.14C (129 aa) and O06415|Rv0549c|MTCY25D10.28C (137 aa).;gbkey=CDS;gene=vapC12;locus_tag=Rv1720c;product=Possible toxin VapC12;protein_id=CCP44486.1;transl_table=11
AL123456.3	EMBL	gene	1947416	1947643	.	-	.	ID=gene-Rv1721c;Name=vapB12;gbkey=Gene;gene=vapB12;gene_biotype=protein_coding;locus_tag=Rv1721c
AL123456.3	EMBL	CDS	1947416	1947643	.	-	0	ID=cds-CCP44487.1;Parent=gene-Rv1721c;Dbxref=EnsemblGenomes-Gn:Rv1721c,EnsemblGenomes-Tr:CCP44487,GOA:P9WJ53,InterPro:IPR010985,NCBI_GP:CCP44487.1;Name=CCP44487.1;Note=Rv1721c%2C (MTCY04C12.06c)%2C len: 75 aa. Possible vapB12%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv1720c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others from Mycobacterium tuberculosis e.g. Rv0300|MTCY63.05|O07227 conserved hypothetical protein (73 aa). Start changed since original submission.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB12;locus_tag=Rv1721c;product=Possible antitoxin VapB12;protein_id=CCP44487.1;transl_table=11
AL123456.3	EMBL	gene	1947861	1949345	.	+	.	ID=gene-Rv1722;Name=Rv1722;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1722
AL123456.3	EMBL	CDS	1947861	1949345	.	+	0	ID=cds-CCP44488.1;Parent=gene-Rv1722;Dbxref=EnsemblGenomes-Gn:Rv1722,EnsemblGenomes-Tr:CCP44488,GOA:P71980,InterPro:IPR011761,InterPro:IPR013816,UniProtKB/TrEMBL:P71980,NCBI_GP:CCP44488.1;Name=CCP44488.1;Note=Rv1722%2C (MTCY04C12.07)%2C len: 494 aa. Possible carboxylases. Weak similarity to several e.g. ACCC_BACSU|P49787 biotin carboxylase from Bacillus subtilis (448 aa)%2C fasta scores: opt: 171%2C E(): 0.00021%2C (22.8%25 identity in 237 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1722;product=Possible carboxylase;protein_id=CCP44488.1;transl_table=11
AL123456.3	EMBL	gene	1949342	1950589	.	+	.	ID=gene-Rv1723;Name=Rv1723;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1723
AL123456.3	EMBL	CDS	1949342	1950589	.	+	0	ID=cds-CCP44489.1;Parent=gene-Rv1723;Dbxref=EnsemblGenomes-Gn:Rv1723,EnsemblGenomes-Tr:CCP44489,GOA:P71981,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:P71981,NCBI_GP:CCP44489.1;Name=CCP44489.1;Note=Rv1723%2C (MTCY04C12.08)%2C len: 415 aa. Possible hydrolase%2C similar to others e.g. NYLB_FLASP|P07061 6-aminohexanoate-dimer hydrolase from Flavobacterium sp. (392 aa)%2C FASTA scores: opt: 717%2C E(): 0%2C (35.1%25 identity in 396 aa overlap). Also similar to M. tuberculosis hypothetical esterases and penicillin binding proteins e.g. Rv1923%2C Rv1497%2C Rv2463%2C etc;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1723;product=Probable hydrolase;protein_id=CCP44489.1;transl_table=11
AL123456.3	EMBL	gene	1950632	1951051	.	-	.	ID=gene-Rv1724c;Name=Rv1724c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1724c
AL123456.3	EMBL	CDS	1950632	1951051	.	-	0	ID=cds-CCP44490.1;Parent=gene-Rv1724c;Dbxref=EnsemblGenomes-Gn:Rv1724c,EnsemblGenomes-Tr:CCP44490,UniProtKB/TrEMBL:P71982,NCBI_GP:CCP44490.1;Name=CCP44490.1;Note=Rv1724c%2C (MTCY04C12.09c)%2C len: 139 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1724c;product=Hypothetical protein;protein_id=CCP44490.1;transl_table=11
AL123456.3	EMBL	gene	1951041	1951751	.	-	.	ID=gene-Rv1725c;Name=Rv1725c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1725c
AL123456.3	EMBL	CDS	1951041	1951751	.	-	0	ID=cds-CCP44491.1;Parent=gene-Rv1725c;Dbxref=EnsemblGenomes-Gn:Rv1725c,EnsemblGenomes-Tr:CCP44491,InterPro:IPR002577,InterPro:IPR003033,InterPro:IPR011991,UniProtKB/TrEMBL:P71983,NCBI_GP:CCP44491.1;Name=CCP44491.1;Note=Rv1725c%2C (MTCY04C12.10c)%2C len: 236 aa. Conserved hypothetical protein%2C similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from butyrivibrio fibrisolvens%2C (108 aa)%2C FASTA scores: opt: 223%2C E(): 2e-09%2C (39.1%25 identity in 92 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical transcriptional regulator%2C O05774|Rv3095|YU95_MYCTU (158 aa).;gbkey=CDS;locus_tag=Rv1725c;product=Conserved hypothetical protein;protein_id=CCP44491.1;transl_table=11
AL123456.3	EMBL	gene	1951852	1953237	.	+	.	ID=gene-Rv1726;Name=Rv1726;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1726
AL123456.3	EMBL	CDS	1951852	1953237	.	+	0	ID=cds-CCP44492.1;Parent=gene-Rv1726;Dbxref=EnsemblGenomes-Gn:Rv1726,EnsemblGenomes-Tr:CCP44492,GOA:P71984,InterPro:IPR006094,InterPro:IPR012951,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,UniProtKB/TrEMBL:P71984,NCBI_GP:CCP44492.1;Name=CCP44492.1;Note=Rv1726%2C (MTCY04C12.11)%2C len: 461 aa. Probable oxidoreductase%2C similar to HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa)%2C FASTA scores: opt: 678%2C E(): 0%2C (29.5%25 identity in 465 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv3107c%2C Rv1257c%2C etc.;gbkey=CDS;locus_tag=Rv1726;product=Probable oxidoreductase;protein_id=CCP44492.1;transl_table=11
AL123456.3	EMBL	gene	1952291	1952503	.	-	.	ID=gene-AS1726;Name=AS1726;gbkey=Gene;gene=AS1726;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1952291	1952503	.	-	.	ID=rna-AS1726;Parent=gene-AS1726;Note=AS1726%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 1952400%2C1952375%2C 1952367%2C and 1952351.;gbkey=ncRNA;gene=AS1726;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1952291	1952503	.	-	.	ID=exon-AS1726-1;Parent=rna-AS1726;Note=AS1726%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 1952400%2C1952375%2C 1952367%2C and 1952351.;gbkey=ncRNA;gene=AS1726;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1953270	1953839	.	+	.	ID=gene-Rv1727;Name=Rv1727;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1727
AL123456.3	EMBL	CDS	1953270	1953839	.	+	0	ID=cds-CCP44493.1;Parent=gene-Rv1727;Dbxref=EnsemblGenomes-Gn:Rv1727,EnsemblGenomes-Tr:CCP44493,GOA:P71985,InterPro:IPR017517,InterPro:IPR017520,InterPro:IPR024344,UniProtKB/TrEMBL:P71985,NCBI_GP:CCP44493.1;Name=CCP44493.1;Note=Rv1727%2C (MTCY04C12.12)%2C len: 189 aa. Conserved hypothetical protein%2C similar to Mycobacterium tuberculosis hypothetical proteins P72040|Rv3773c|MTCY13D12.07C (194 aa)%2C FASTA scores: opt: 176%2C E(): 2.7e-08%2C (31.1%25 identity in 180 aa overlap)%3B and O53801|Rv0738 (182 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1727;product=Conserved hypothetical protein;protein_id=CCP44493.1;transl_table=11
AL123456.3	EMBL	gene	1953864	1954634	.	-	.	ID=gene-Rv1728c;Name=Rv1728c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1728c
AL123456.3	EMBL	CDS	1953864	1954634	.	-	0	ID=cds-CCP44494.1;Parent=gene-Rv1728c;Dbxref=EnsemblGenomes-Gn:Rv1728c,EnsemblGenomes-Tr:CCP44494,GOA:P71986,UniProtKB/TrEMBL:P71986,NCBI_GP:CCP44494.1;Name=CCP44494.1;Note=Rv1728c%2C (MTCY04C12.13c)%2C len: 256 aa. Conserved hypothetical protein%2C some similarity to O07246|Rv0320|MTCY63.25 possible exported protein from Mycobacterium tuberculosis (220 aa)%2C FASTA scores: E(): 1.3e-31%2C (42.3%25 identity in 220 aa overlap). C-terminal region similar to Q9ZX60|AF068845|AF068845_17 segment of gp17 of Mycobacteriophage TM4 (1229 aa)%2C FASTA scores: opt: 385%2C E(): 4.3e-17%2C (44.6%25 identity in 139 aa overlap).;gbkey=CDS;locus_tag=Rv1728c;product=Conserved hypothetical protein;protein_id=CCP44494.1;transl_table=11
AL123456.3	EMBL	gene	1954631	1955569	.	-	.	ID=gene-Rv1729c;Name=Rv1729c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1729c
AL123456.3	EMBL	CDS	1954631	1955569	.	-	0	ID=cds-CCP44495.1;Parent=gene-Rv1729c;Dbxref=EnsemblGenomes-Gn:Rv1729c,EnsemblGenomes-Tr:CCP44495,GOA:P9WFH9,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP44495.1;Name=CCP44495.1;Note=Rv1729c%2C (MTCY04C12.14c)%2C len: 312 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C similar to many Mycobacterium tuberculosis proteins e.g. Q50726|Rv3399|YX99_MYCTU (348 aa)%2C FASTA scores: opt: 1019%2C E(): 0%2C (55.7%25 identity in 296 aa overlap)%3B P95074|Rv0726c (367 aa)%2C O53795|Rv0731c (318 aa)%2Cand O53841|Rv0830 (301 aa)%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1729c;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP44495.1;transl_table=11
AL123456.3	EMBL	gene	1955692	1957245	.	-	.	ID=gene-Rv1730c;Name=Rv1730c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1730c
AL123456.3	EMBL	CDS	1955692	1957245	.	-	0	ID=cds-CCP44496.1;Parent=gene-Rv1730c;Dbxref=EnsemblGenomes-Gn:Rv1730c,EnsemblGenomes-Tr:CCP44496,GOA:P71988,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:P71988,NCBI_GP:CCP44496.1;Name=CCP44496.1;Note=Rv1730c%2C (MTCY04C12.15c)%2C len: 517 aa. Possible penicillin-binding protein%2C similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa)%2C FASTA scores: opt: 643%2CE(): 3.8e-32%2C (33.8%25 identity in 370 aa overlap)%3B etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923%2CRv1497%2C etc.;gbkey=CDS;locus_tag=Rv1730c;product=Possible penicillin-binding protein;protein_id=CCP44496.1;transl_table=11
AL123456.3	EMBL	gene	1957677	1959233	.	+	.	ID=gene-Rv1731;Name=gabD2;gbkey=Gene;gene=gabD2;gene_biotype=protein_coding;gene_synonym=gabD1;locus_tag=Rv1731
AL123456.3	EMBL	CDS	1957677	1959233	.	+	0	ID=cds-CCP44497.1;Parent=gene-Rv1731;Dbxref=EnsemblGenomes-Gn:Rv1731,EnsemblGenomes-Tr:CCP44497,GOA:P9WNX7,InterPro:IPR015590,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR029510,NCBI_GP:CCP44497.1;Name=CCP44497.1;Note=Rv1731%2C (MTCY04C12.16)%2C len: 518 aa. Possible gabD2%2Csuccinate-semialdehyde dehydrogenase [NADP+] dependent%2Csimilar to others e.g. GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase from Escherichia coli (482 aa)%2C FASTA scores: opt: 870%2C E(): 0%2C (34.7%25 identity in 449 aa overlap)%3B etc. Also similar to gabD1|Rv0234c|MTCY08D5.30c probable succinate-semialdehyde dehydrogenase [NADP+] dependent from Mycobacterium tuberculosis (511 aa)%3B and other semialdehyde dehydrogenases e.g. Rv0768|aldA (489 aa)%2C Rv2858c|aldC (455 aa)%2C etc. Contains PS00216 Sugar transport proteins signature 1%2C PS00687 Aldehyde dehydrogenases glutamic acid active site. Belongs to the aldehyde dehydrogenases family. Note that previously known as gabD1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gabD2;inference=protein motif:PROSITE:PS00687;locus_tag=Rv1731;product=Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2;protein_id=CCP44497.1;transl_table=11
AL123456.3	EMBL	gene	1959243	1959791	.	-	.	ID=gene-Rv1732c;Name=Rv1732c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1732c
AL123456.3	EMBL	CDS	1959243	1959791	.	-	0	ID=cds-CCP44498.1;Parent=gene-Rv1732c;Dbxref=EnsemblGenomes-Gn:Rv1732c,EnsemblGenomes-Tr:CCP44498,GOA:P71990,InterPro:IPR000866,InterPro:IPR012336,UniProtKB/TrEMBL:P71990,NCBI_GP:CCP44498.1;Name=CCP44498.1;Note=Rv1732c%2C (MTCY04C12.17c)%2C len: 182 aa. Conserved protein%2C highly similar to hypothetical proteins from several organisms e.g. P73178|SLL1289|D90904 from Synechocystis (194 aa)%2C FASTA scores: opt: 663%2C E(): 0%2C(53.1%25 identity in 179 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1732c;product=Conserved protein;protein_id=CCP44498.1;transl_table=11
AL123456.3	EMBL	gene	1959855	1960487	.	-	.	ID=gene-Rv1733c;Name=Rv1733c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1733c
AL123456.3	EMBL	CDS	1959855	1960487	.	-	0	ID=cds-CCP44499.1;Parent=gene-Rv1733c;Dbxref=EnsemblGenomes-Gn:Rv1733c,EnsemblGenomes-Tr:CCP44499,GOA:P9WLS9,NCBI_GP:CCP44499.1;Name=CCP44499.1;Note=Rv1733c%2C (MTCY04C12.18c)%2C len: 210 aa. Probable conserved transmembrane protein. Similar to AL109962|SCJ1_26 hypothetical protein from Streptomyces coelicolor (193 aa)%2C FASTA scores: opt: 287%2C E(): 3.8e-11%2C(35.2%25 identity in 182 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1733c;product=Probable conserved transmembrane protein;protein_id=CCP44499.1;transl_table=11
AL123456.3	EMBL	gene	1960667	1960783	.	+	.	ID=gene-MTS1338;Name=MTS1338;gbkey=Gene;gene=MTS1338;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	1960667	1960783	.	+	.	ID=rna-MTS1338;Parent=gene-MTS1338;Note=MTS1338%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C 5'-end mapped by RLM-RACE%2C alternate 5'-end at position 1960601%2C ~~100 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS1338;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	1960667	1960783	.	+	.	ID=exon-MTS1338-1;Parent=rna-MTS1338;Note=MTS1338%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C 5'-end mapped by RLM-RACE%2C alternate 5'-end at position 1960601%2C ~~100 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS1338;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	1960774	1961016	.	-	.	ID=gene-Rv1734c;Name=Rv1734c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1734c
AL123456.3	EMBL	CDS	1960774	1961016	.	-	0	ID=cds-CCP44500.1;Parent=gene-Rv1734c;Dbxref=EnsemblGenomes-Gn:Rv1734c,EnsemblGenomes-Tr:CCP44500,GOA:P9WLS7,InterPro:IPR001078,InterPro:IPR023213,NCBI_GP:CCP44500.1;Name=CCP44500.1;Note=Rv1734c%2C (MTCY04C12.19c)%2C len: 80 aa. Conserved hypothetical protein%2C similar to C-terminal region Q9Z8N2|CP0452|AE001615 Dihydrolipoamide Acetyltransferase from Chlamydia pneumoniae (429 aa)%2C FASTA scores: opt: 138%2CE(): 0.0012%2C (26.9%25 identity in 78 aa overlap).;gbkey=CDS;locus_tag=Rv1734c;product=Conserved hypothetical protein;protein_id=CCP44500.1;transl_table=11
AL123456.3	EMBL	gene	1961291	1961788	.	-	.	ID=gene-Rv1735c;Name=Rv1735c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1735c
AL123456.3	EMBL	CDS	1961291	1961788	.	-	0	ID=cds-CCP44501.1;Parent=gene-Rv1735c;Dbxref=EnsemblGenomes-Gn:Rv1735c,EnsemblGenomes-Tr:CCP44501,GOA:P9WLS5,InterPro:IPR004695,NCBI_GP:CCP44501.1;Name=CCP44501.1;Note=Rv1735c%2C (MTCY04C12.20c)%2C len: 165 aa. Hypothetical membrane protein%2C similar to part of O58614|PH0884|AP000004 Hypothetical malic acid transport protein from Pyrococcus horikoshii (330 aa)%2C FASTA scores: opt: 167%2C E(): 0.0003%2C(29.2%25 identity in 120 aa overlap).;gbkey=CDS;locus_tag=Rv1735c;product=Hypothetical membrane protein;protein_id=CCP44501.1;transl_table=11
AL123456.3	EMBL	gene	1962228	1964186	.	-	.	ID=gene-Rv1736c;Name=narX;gbkey=Gene;gene=narX;gene_biotype=protein_coding;locus_tag=Rv1736c
AL123456.3	EMBL	CDS	1962228	1964186	.	-	0	ID=cds-CCP44502.1;Parent=gene-Rv1736c;Dbxref=EnsemblGenomes-Gn:Rv1736c,EnsemblGenomes-Tr:CCP44502,GOA:P9WJQ1,InterPro:IPR003765,InterPro:IPR003816,InterPro:IPR006656,InterPro:IPR006963,InterPro:IPR020945,InterPro:IPR023234,InterPro:IPR027467,NCBI_GP:CCP44502.1;Name=CCP44502.1;Note=Rv1736c%2C (MTCY04C12.21c)%2C len: 652 aa. Probable narX%2C nitrate reductase. Contains three domains: N-terminus (250 aa) is similar to e.g. N-terminus of NARG_ECOLI|P09152 respiratory nitrate reductase 1 alpha chain from Escherichia coli (1246 aa)%2C FASTA scores: E(): 0%2C (58.6%25 identity in 251 aa overlap)%3B and Rv1161|MTCI65.28|NARG probable respiratory nitrate reductase (alpha chain) from Mycobacterium tuberculosis (1232 aa). Central region (260-410 aa) is similar to Rv1163|O06561|NARJ probable respiratory nitrate reductase (delta chain) from Mycobacterium tuberculosis (201 aa)%2C FASTA scores: E(): 0%2C(64.2%25 identity in 159 aa overlap). C-terminus (420 aa-) is similar to Rv1164|O06562|NARI probable respiratory nitrate reductase (gamma chain) from Mycobacterium tuberculosis (246 aa)%2C FASTA scores: E(): 0%2C (68.6%25 identity in 239 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narX;inference=protein motif:PROSITE:PS00551;locus_tag=Rv1736c;product=Probable nitrate reductase NarX;protein_id=CCP44502.1;transl_table=11
AL123456.3	EMBL	gene	1964183	1965370	.	-	.	ID=gene-Rv1737c;Name=narK2;gbkey=Gene;gene=narK2;gene_biotype=protein_coding;locus_tag=Rv1737c
AL123456.3	EMBL	CDS	1964183	1965370	.	-	0	ID=cds-CCP44503.1;Parent=gene-Rv1737c;Dbxref=EnsemblGenomes-Gn:Rv1737c,EnsemblGenomes-Tr:CCP44503,GOA:P9WJY7,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP44503.1;Name=CCP44503.1;Note=Rv1737c%2C (MTCY04C12.22c)%2C len: 395 aa. Possible narK2%2C nitrate/nitrite-transport integral membrane protein (see Hutter %26 Dick 2000)%2C possibly member of major facilitator superfamily (MFS)%2C similar to P46907|NARK_BACSU nitrite extrusion protein from Bacillus subtilis (395 aa)%2CFASTA scores: opt: 742%2C E(): 0%2C (33.6%25 identity in 375 aa overlap)%3B and to AL109989|SCJ12.23 hypothetical nitrate/nitrite transporter from Streptomyces coelicolor (412 aa)%2C FASTA scores: opt: 1181%2C E(): 0%2C (49.4%25 identity in 389 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=narK2;locus_tag=Rv1737c;product=Possible nitrate/nitrite transporter NarK2;protein_id=CCP44503.1;transl_table=11
AL123456.3	EMBL	gene	1965657	1965941	.	+	.	ID=gene-Rv1738;Name=Rv1738;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1738
AL123456.3	EMBL	CDS	1965657	1965941	.	+	0	ID=cds-CCP44504.1;Parent=gene-Rv1738;Dbxref=EnsemblGenomes-Gn:Rv1738,EnsemblGenomes-Tr:CCP44504,GOA:P9WLS3,InterPro:IPR015057,NCBI_GP:CCP44504.1;Name=CCP44504.1;Note=Rv1738%2C (MTCY04C12.23)%2C len: 94 aa. Conserved protein%2C similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa)%2CFASTA scores: opt: 319%2C E(): 2.6e-27%2C (53.9%25 identity in 89 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1738;product=Conserved protein;protein_id=CCP44504.1;transl_table=11
AL123456.3	EMBL	gene	1965955	1967637	.	-	.	ID=gene-Rv1739c;Name=Rv1739c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1739c
AL123456.3	EMBL	CDS	1965955	1967637	.	-	0	ID=cds-CCP44505.1;Parent=gene-Rv1739c;Dbxref=EnsemblGenomes-Gn:Rv1739c,EnsemblGenomes-Tr:CCP44505,GOA:P9WGF7,InterPro:IPR001902,InterPro:IPR002645,InterPro:IPR011547,NCBI_GP:CCP44505.1;Name=CCP44505.1;Note=Rv1739c%2C (MTCY04C12.24c%2C MTCY28.01)%2C len: 560 aa. Probable sulphate-transport transmembrane protein ABC transporter%2C similar to several e.g. P53392|G607186 high affinity sulphate transporter from Stylosanthes hamata (662 aa)%2C FASTA scores: opt: 382%2C E(): 1.6e-16%2C (28.0%25 identity in 564 aa overlap)%3B U59234.1|AAB88215.1 biotin carb. from Synechococcus sp. PCC 7942 (574 aa)%2C FASTA scores: opt: 1838%2C E(): 0%2C (50.0%25 identity in 550 aa overlap)%3B etc. Contains PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters)%2C and seems to belong to the SULP family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1739c;product=Probable sulphate-transport transmembrane protein ABC transporter;protein_id=CCP44505.1;transl_table=11
AL123456.3	EMBL	gene	1967705	1967917	.	+	.	ID=gene-Rv1740;Name=vapB34;gbkey=Gene;gene=vapB34;gene_biotype=protein_coding;locus_tag=Rv1740
AL123456.3	EMBL	CDS	1967705	1967917	.	+	0	ID=cds-CCP44506.1;Parent=gene-Rv1740;Dbxref=EnsemblGenomes-Gn:Rv1740,EnsemblGenomes-Tr:CCP44506,InterPro:IPR011660,NCBI_GP:CCP44506.1;Name=CCP44506.1;Note=Rv1740%2C (MTCY28.02-MTCY04C12.25)%2C len: 70 aa. Possible vapB34%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv1741%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. P96913|Rv0623|MTCY20H10.04 (84 aa)%2C (73.5%25 identity in 68 aa overlap)%3B P71998|Rv1740 (70 aa)%2C and O07770|Rv0608 (81 aa).;gbkey=CDS;gene=vapB34;locus_tag=Rv1740;product=Possible antitoxin VapB34;protein_id=CCP44506.1;transl_table=11
AL123456.3	EMBL	gene	1967917	1968165	.	+	.	ID=gene-Rv1741;Name=vapC34;gbkey=Gene;gene=vapC34;gene_biotype=protein_coding;locus_tag=Rv1741
AL123456.3	EMBL	CDS	1967917	1968165	.	+	0	ID=cds-CCP44507.1;Parent=gene-Rv1741;Dbxref=EnsemblGenomes-Gn:Rv1741,EnsemblGenomes-Tr:CCP44507,GOA:P9WF71,InterPro:IPR029060,NCBI_GP:CCP44507.1;Name=CCP44507.1;Note=Rv1741%2C (MTCY28.03%2CMTCY04C12.26)%2C len: 82 aa. Possible vapC34%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv1740%2C contains PIN domain%2C see Arcus et al. 2005. Similar in N-terminus to others in Mycobacterium tuberculosis e.g. P96914|Rv0624|MTCY20H10.05 (131 aa)%2C(80.4%25 identity in 56 aa overlap)%3B P71999|Rv1741 (82 aa) and O07769|Rv0609 (133 aa).;gbkey=CDS;gene=vapC34;locus_tag=Rv1741;product=Possible toxin VapC34. Contains PIN domain.;protein_id=CCP44507.1;transl_table=11
AL123456.3	EMBL	gene	1968173	1968910	.	+	.	ID=gene-Rv1742;Name=Rv1742;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1742
AL123456.3	EMBL	CDS	1968173	1968910	.	+	0	ID=cds-CCP44508.1;Parent=gene-Rv1742;Dbxref=EnsemblGenomes-Gn:Rv1742,EnsemblGenomes-Tr:CCP44508,GOA:O33271,UniProtKB/TrEMBL:O33271,NCBI_GP:CCP44508.1;Name=CCP44508.1;Note=Rv1742%2C (MTCY28.04%2CMTCY04C12.27)%2C len: 245 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1742;product=Unknown protein;protein_id=CCP44508.1;transl_table=11
AL123456.3	EMBL	gene	1969004	1970704	.	+	.	ID=gene-Rv1743;Name=pknE;gbkey=Gene;gene=pknE;gene_biotype=protein_coding;locus_tag=Rv1743
AL123456.3	EMBL	CDS	1969004	1970704	.	+	0	ID=cds-CCP44509.1;Parent=gene-Rv1743;Dbxref=EnsemblGenomes-Gn:Rv1743,EnsemblGenomes-Tr:CCP44509,GOA:P9WI77,InterPro:IPR000719,InterPro:IPR011009,InterPro:IPR012336,InterPro:IPR017441,PDB:2H34,NCBI_GP:CCP44509.1;Name=CCP44509.1;Note=Rv1743%2C (MTCY28.05%2CMTCY04C12.28)%2C len: 566 aa. Probable pknE%2C transmembrane serine/threonine protein kinase (see citation below)%2C similar to PKN1_MYXXA|P33973 serine/threonine-protein kinase pkn1 (693 aa)%2C fasta scores: opt: 542%2C E(): 1.1e-19%2C (35.8%25 identity in 302 aa overlap). Also highly similar to K08G_MYCTU|Q11053 probable serine/threonine-protein kinase (626 aa) (59.8%25 identity in 381 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknE;inference=protein motif:PROSITE:PS00107;locus_tag=Rv1743;product=Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E);protein_id=CCP44509.1;transl_table=11
AL123456.3	EMBL	gene	1970989	1971390	.	-	.	ID=gene-Rv1744c;Name=Rv1744c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1744c
AL123456.3	EMBL	CDS	1970989	1971390	.	-	0	ID=cds-CCP44510.1;Parent=gene-Rv1744c;Dbxref=EnsemblGenomes-Gn:Rv1744c,EnsemblGenomes-Tr:CCP44510,InterPro:IPR016133,UniProtKB/TrEMBL:O06787,NCBI_GP:CCP44510.1;Name=CCP44510.1;Note=Rv1744c%2C (MTCY28.06c)%2C len: 133 aa. Probable membrane protein%2C contains four imperfect 10 aa repeats%2Csome similarity to Q25946 (MSA-2) (fragment) from Plasmodium falciparum (205 aa)%2C FASTA scores: opt: 145%2C E( ): 0.048%2C (52.4%25 identity in 63 aa overlap).;gbkey=CDS;locus_tag=Rv1744c;product=Probable membrane protein;protein_id=CCP44510.1;transl_table=11
AL123456.3	EMBL	gene	1971380	1971991	.	-	.	ID=gene-Rv1745c;Name=idi;gbkey=Gene;gene=idi;gene_biotype=protein_coding;locus_tag=Rv1745c
AL123456.3	EMBL	CDS	1971380	1971991	.	-	0	ID=cds-CCP44511.1;Parent=gene-Rv1745c;Dbxref=EnsemblGenomes-Gn:Rv1745c,EnsemblGenomes-Tr:CCP44511,GOA:P9WKK5,InterPro:IPR000086,InterPro:IPR011876,InterPro:IPR015797,NCBI_GP:CCP44511.1;Name=CCP44511.1;Note=Rv1745c%2C (MTCY28.08c%2CMTCY04C12.29c)%2C len: 203 aa. Probable idi%2C isopentenyl-diphosphate delta-isomerase%2Csimilar to Q46822|ORF_O182 from Escherichia coli (182 aa)%2CFASTA scores: opt: 465%2C E(): 4.7e-25%2C (46.9%25 identity in 162 aa overlap)%2C and to IPPI_SCHPO|Q10132 isopentenyl-diphosphate delta-isomerase from Schizosaccharomyces pombe (227 aa)%2C FASTA scores: opt: 185%2CE(): 5.4e-06%2C (30.3%25 identity in 152 aa overlap). Belongs to the IPP isomerase type 1 family.;gbkey=CDS;gene=idi;locus_tag=Rv1745c;product=Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase);protein_id=CCP44511.1;transl_table=11
AL123456.3	EMBL	gene	1972138	1973568	.	+	.	ID=gene-Rv1746;Name=pknF;gbkey=Gene;gene=pknF;gene_biotype=protein_coding;locus_tag=Rv1746
AL123456.3	EMBL	CDS	1972138	1973568	.	+	0	ID=cds-CCP44512.1;Parent=gene-Rv1746;Dbxref=EnsemblGenomes-Gn:Rv1746,EnsemblGenomes-Tr:CCP44512,GOA:P9WI75,InterPro:IPR000719,InterPro:IPR008271,InterPro:IPR011009,NCBI_GP:CCP44512.1;Name=CCP44512.1;Note=Rv1746%2C (MTCY28.09%2C MTCY04C12.30)%2C len: 476 aa. pknF%2C transmembrane serine/threonine-protein kinase (see citations below)%2C highly similar to KY28_MYCTU|Q10697 probable serine/threonine-protein kinase from Mycobacterium tuberculosis (589 aa)%2C FASTA scores: opt: 870%2C E(): 0%2C(41.6%25 identity in 406 aa overlap). Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation. Start site chosen by homology%2C may extend further upstream.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknF;inference=protein motif:PROSITE:PS00108;locus_tag=Rv1746;product=Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F);protein_id=CCP44512.1;transl_table=11
AL123456.3	EMBL	gene	1973630	1976227	.	+	.	ID=gene-Rv1747;Name=Rv1747;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1747
AL123456.3	EMBL	CDS	1973630	1976227	.	+	0	ID=cds-CCP44513.1;Parent=gene-Rv1747;Dbxref=EnsemblGenomes-Gn:Rv1747,EnsemblGenomes-Tr:CCP44513,GOA:O65934,InterPro:IPR000253,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR008984,InterPro:IPR013525,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP44513.1;Name=CCP44513.1;Note=Rv1747%2C (MTCY28.10%2C MTCY04C12.31)%2C len: 865 aa. Probable conserved transmembrane ATP-binding protein ABC transporter (see citation below)%2C similar to others e.g Q55956 ABC transporter from Synechocystis sp. (790 aa)%2CFASTA scores: opt: 738%2C E(): 6.3e-26%2C (31.6%25 identity in 632 aa overlap)%3B etc. Also similar to other M. tuberculosis ABC-type transporters e.g. Rv2397c|MTCY253.24%2C FASTA score: (35.2%25 identity in 213 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1747;product=Probable conserved transmembrane ATP-binding protein ABC transporter;protein_id=CCP44513.1;transl_table=11
AL123456.3	EMBL	gene	1976600	1977331	.	+	.	ID=gene-Rv1748;Name=Rv1748;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1748
AL123456.3	EMBL	CDS	1976600	1977331	.	+	0	ID=cds-CCP44514.1;Parent=gene-Rv1748;Dbxref=EnsemblGenomes-Gn:Rv1748,EnsemblGenomes-Tr:CCP44514,GOA:P72005,UniProtKB/TrEMBL:P72005,NCBI_GP:CCP44514.1;Name=CCP44514.1;Note=Rv1748%2C (MTCY28.11%2C MTCY04C12.32)%2C len: 243 aa. Unknown protein. Possibly exported protein%2C hydrophobic domain%2C TM helix aa 23-45.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1748;product=Unknown protein;protein_id=CCP44514.1;transl_table=11
AL123456.3	EMBL	gene	1977328	1977885	.	-	.	ID=gene-Rv1749c;Name=Rv1749c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1749c
AL123456.3	EMBL	CDS	1977328	1977885	.	-	0	ID=cds-CCP44515.1;Parent=gene-Rv1749c;Dbxref=EnsemblGenomes-Gn:Rv1749c,EnsemblGenomes-Tr:CCP44515,UniProtKB/TrEMBL:O65935,NCBI_GP:CCP44515.1;Name=CCP44515.1;Note=Rv1749c%2C (MTCY28.12c-MTCY04C12.33c)%2C len: 185 aa. Possible integral membrane protein%2C similar to O27914|AE000940 hypothetical protein MTH1892 from Methanobacterium thermoautotrophicum (168 aa)%2C fasta scores: E(): 9.3e-16%2C (37.4%25 identity in 123 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1749c;product=Possible integral membrane protein;protein_id=CCP44515.1;transl_table=11
AL123456.3	EMBL	gene	1977969	1979567	.	-	.	ID=gene-Rv1750c;Name=fadD1;gbkey=Gene;gene=fadD1;gene_biotype=protein_coding;locus_tag=Rv1750c
AL123456.3	EMBL	CDS	1977969	1979567	.	-	0	ID=cds-CCP44516.1;Parent=gene-Rv1750c;Dbxref=EnsemblGenomes-Gn:Rv1750c,EnsemblGenomes-Tr:CCP44516,GOA:P72007,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:P72007,NCBI_GP:CCP44516.1;Name=CCP44516.1;Note=Rv1750c%2C (MTCY28.13c%2C MTCY04C12.34)%2C len: 532 aa. Possible fadD1%2C fatty-acid-CoA synthetase%2C similar in part to others e.g. O35488|VLCS_MOUSE very-long-chain acyl-CoA synthetase from Mus musculus (620 aa)%3B NP_113924.1|NM_031736 solute carrier family 27 (fatty acid transporter) member 2 from Rattus norvegicus (620 aa)%3B NP_459076.1|NC_003197 crotonobetaine/carnitine-CoA ligase from Salmonella typhimurium (517 aa)%3B CAIC_ECOLI|P31552 probable crotonobetaine/carnitine-CoA ligase from Escherichia coli (522 aa)%2C FASTA scores: opt: 448%2C E(): 1.9e-21%2C (25.1%25 identity in 502 aa overlap)%3B etc. Also highly similar to fadD17|Rv3506|MTV023.13 probable fatty-acid-CoA ligase from Mycobacterium tuberculosis (502 aa)%3B and similar to others from Mycobacterium tuberculosis e.g. fadD6|MTCI364.18|Rv1206|O05307 probable fatty-acid-CoA ligase (597 aa)%2C FASTA score: (28.3%25 identity in 519 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD1;inference=protein motif:PROSITE:PS00455;locus_tag=Rv1750c;product=Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP44516.1;transl_table=11
AL123456.3	EMBL	gene	1979621	1981003	.	+	.	ID=gene-Rv1751;Name=Rv1751;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1751
AL123456.3	EMBL	CDS	1979621	1981003	.	+	0	ID=cds-CCP44517.1;Parent=gene-Rv1751;Dbxref=EnsemblGenomes-Gn:Rv1751,EnsemblGenomes-Tr:CCP44517,GOA:O65936,InterPro:IPR002938,InterPro:IPR003042,UniProtKB/TrEMBL:O65936,NCBI_GP:CCP44517.1;Name=CCP44517.1;Note=Rv1751%2C (MTCY28.14-MTCY04C12.35)%2C len: 460 aa. Probable oxidoreductase%2C possibly a monooxygenase or hydroxylase%2C similar to MHPA_ECOLI|P77397 3-(3-hydroxy-phenyl) propionate hydroxylase (554 aa)%2C FASTA scores: opt: 239%2C E(): 2e-08%2C (24.6%25 identity in 435 aa overlap)%3B and AJ007932|SAR7932.13 oxygenase from Streptomyces argillaceus (436 aa)%2C FASTA scores: opt: 587%2CE(): 8.6e-30%2C (32.3%25 identity in 359 aa overlap). Contains PS00075 Dihydrofolate reductase signature. Also similar to Mycobacterium tuberculosis hypothetical oxidoreductases Rv1260 and Rv0575c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00075;locus_tag=Rv1751;product=Probable oxidoreductase;protein_id=CCP44517.1;transl_table=11
AL123456.3	EMBL	gene	1981130	1981579	.	+	.	ID=gene-Rv1752;Name=Rv1752;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1752
AL123456.3	EMBL	CDS	1981130	1981579	.	+	0	ID=cds-CCP44518.1;Parent=gene-Rv1752;Dbxref=EnsemblGenomes-Gn:Rv1752,EnsemblGenomes-Tr:CCP44518,UniProtKB/TrEMBL:O06789,NCBI_GP:CCP44518.1;Name=CCP44518.1;Note=Rv1752%2C (MTCY28.15)%2C len: 149 aa. Conserved hypothetical protein%2C similar to C-terminal half of Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase from Canis familiaris (335 aa)%2C FASTA score%2C opt: 168%2C E(): 0.00015%2C(31.3%25 identity in 112 aa overlap).;gbkey=CDS;locus_tag=Rv1752;product=Conserved hypothetical protein;protein_id=CCP44518.1;transl_table=11
AL123456.3	EMBL	gene	1981614	1984775	.	-	.	ID=gene-Rv1753c;Name=PPE24;gbkey=Gene;gene=PPE24;gene_biotype=protein_coding;locus_tag=Rv1753c
AL123456.3	EMBL	CDS	1981614	1984775	.	-	0	ID=cds-CCP44519.1;Parent=gene-Rv1753c;Dbxref=EnsemblGenomes-Gn:Rv1753c,EnsemblGenomes-Tr:CCP44519,GOA:P9WI15,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP44519.1;Name=CCP44519.1;Note=Rv1753c%2C (MTCY28.16c)%2C len: 1053 aa. PPE24%2C Member of the Mycobacterium tuberculosis PPE family of Gly-%2CAsn-rich proteins%2C similar to many e.g. YF48_MYCTU|Q10778 hypothetical protein cy48.17 (678 aa)%2C FASTA scores: opt: 1360%2C E(): 0%2C (48.9%25 identity in 550 aa overlap). Note that the Gly-%2C Asn-rich sequence is interrupted by six near-perfect 26 aa repeats%2C a unique region%2C and another%2Cmore degenerate region of five 25 aa repeats before resuming at the C-terminus. The end of the first Gly-%2C Asn-rich region and the start of the first set of repeats shows some similarity to Q50577|AT10S from Mycobacterium tuberculosis (170 aa) (40.2%25 identity in 189 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE24;locus_tag=Rv1753c;product=PPE family protein PPE24;protein_id=CCP44519.1;transl_table=11
AL123456.3	EMBL	repeat_region	1982887	1982964	.	-	.	ID=id-Rv1753c;Note=78 bp imperfect direct repeat 6%2C CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCCGCCAACATCACCGT;gbkey=repeat_region;gene=PPE24;locus_tag=Rv1753c
AL123456.3	EMBL	repeat_region	1982965	1983042	.	-	.	ID=id-Rv1753c-2;Note=78 bp imperfect direct repeat 5%2C CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT;gbkey=repeat_region;gene=PPE24;locus_tag=Rv1753c
AL123456.3	EMBL	repeat_region	1983043	1983120	.	-	.	ID=id-Rv1753c-3;Note=78 bp imperfect direct repeat 4%2C CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT;gbkey=repeat_region;gene=PPE24;locus_tag=Rv1753c
AL123456.3	EMBL	repeat_region	1983121	1983198	.	-	.	ID=id-Rv1753c-4;Note=78 bp imperfect direct repeat 3%2C GGGTGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT;gbkey=repeat_region;gene=PPE24;locus_tag=Rv1753c
AL123456.3	EMBL	repeat_region	1983199	1983276	.	-	.	ID=id-Rv1753c-5;Note=78 bp imperfect direct repeat 2%2C CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC ACACCAGCCAACATCACCGT;gbkey=repeat_region;gene=PPE24;locus_tag=Rv1753c
AL123456.3	EMBL	repeat_region	1983277	1983354	.	-	.	ID=id-Rv1753c-6;Note=78 bp imperfect direct repeat 1%2C TCCCGCCTTCAGTCTGCCGGCAATAACGCTGCCGTCGCTGAACATCCCGGCCGCCACC ACACCGGCCAACATCACCGT;gbkey=repeat_region;gene=PPE24;locus_tag=Rv1753c
AL123456.3	EMBL	gene	1984979	1986670	.	-	.	ID=gene-Rv1754c;Name=Rv1754c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1754c
AL123456.3	EMBL	CDS	1984979	1986670	.	-	0	ID=cds-CCP44520.1;Parent=gene-Rv1754c;Dbxref=EnsemblGenomes-Gn:Rv1754c,EnsemblGenomes-Tr:CCP44520,GOA:O06790,InterPro:IPR025442,UniProtKB/TrEMBL:O06790,NCBI_GP:CCP44520.1;Name=CCP44520.1;Note=Rv1754c%2C (MTCY28.17c)%2C len: 563 aa. Conserved protein%2C has proline-rich central region. Some similarity in central region to other Mycobacterium tuberculosis proline-rich proteins e.g. O06555|Rv1157c|MTCI65.24c (371 aa)%2C (32.5%25 identity in 191 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1754c;product=Conserved protein;protein_id=CCP44520.1;transl_table=11
AL123456.3	EMBL	gene	1986854	1987696	.	-	.	ID=gene-Rv1755c;Name=plcD;end_range=1987696,.;gbkey=Gene;gene=plcD;gene_biotype=protein_coding;locus_tag=Rv1755c;partial=true
AL123456.3	EMBL	CDS	1986854	1987696	.	-	0	ID=cds-CCP44521.1;Parent=gene-Rv1755c;Dbxref=EnsemblGenomes-Gn:Rv1755c,EnsemblGenomes-Tr:CCP44521,GOA:P9WIA9,InterPro:IPR006311,InterPro:IPR007312,NCBI_GP:CCP44521.1;Name=CCP44521.1;Note=Rv1755c%2C (MT1799%2C MTCY28.21c)%2C len: 280 aa. Probable plcD%2C phospholipase C 4 (fragment) (see citations below)%2Chighly similar to C-terminus of other phospholipases e.g. CQ50771|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase C 1 from Mycobacterium tuberculosis (512 aa)%2C FASTA score: (71.1%25 identity in 284 aa overlap)%3B etc. Note that this ORF has been interrupted by insertion of IS6110 element. Belongs to the bacterial phospholipase C family.;end_range=1987696,.;gbkey=CDS;gene=plcD;locus_tag=Rv1755c;partial=true;product=Probable phospholipase C 4 (fragment) PlcD;protein_id=CCP44521.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1987703	1989057	.	-	.	ID=id-AL123456.3:1987703..1989057;Note=IS6110-3%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-3
AL123456.3	EMBL	repeat_region	1987703	1987730	.	+	.	ID=id-AL123456.3:1987703..1987730;Note=28 bp inverted repeat at the left end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC.;gbkey=repeat_region
AL123456.3	EMBL	gene	1987745	1988731	.	-	.	ID=gene-Rv1756c;Name=Rv1756c;end_range=1988731,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1756c;partial=true
AL123456.3	EMBL	CDS	1987745	1988731	.	-	0	ID=cds-CCP44522.1;Parent=gene-Rv1756c;Dbxref=EnsemblGenomes-Gn:Rv1756c,EnsemblGenomes-Tr:CCP44522,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP44522.1;Name=CCP44522.1;Note=Rv1756c%2C (MTCY28.22c)%2C len: 328 aa. Putative Transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv1756c and Rv1757c%2C the sequence UUUUAAAG (directly upstream of Rv1756c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 34 aa);end_range=1988731,.;gbkey=CDS;locus_tag=Rv1756c;partial=true;product=Putative transposase;protein_id=CCP44522.1;transl_table=11
AL123456.3	EMBL	gene	1988680	1989006	.	-	.	ID=gene-Rv1757c;Name=Rv1757c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1757c
AL123456.3	EMBL	CDS	1988680	1989006	.	-	0	ID=cds-CCP44523.1;Parent=gene-Rv1757c;Dbxref=EnsemblGenomes-Gn:Rv1757c,EnsemblGenomes-Tr:CCP44523,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP44523.1;Name=CCP44523.1;Note=Rv1757c%2C (MTCY28.23c)%2C len: 108 aa. Putative Transposase for IS6110 (fragment)%2C identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion element IS6110 hypothetical 12.0 kDa protein (108 aa)%2C fasta scores: E(): 1.4e-43%2C(100.00%25 identity in 108 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv1756c and Rv1757c%2C the sequence UUUUAAAG (directly upstream of Rv1756c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv1757c;product=Putative transposase for insertion sequence element IS6110 (fragment);protein_id=CCP44523.1;transl_table=11
AL123456.3	EMBL	repeat_region	1989030	1989057	.	-	.	ID=id-AL123456.3:1989030..1989057;Note=28 bp inverted repeat at the right end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	1989042	1989566	.	+	.	ID=gene-Rv1758;Name=cut1;gbkey=Gene;gene=cut1;gene_biotype=protein_coding;gene_synonym=clp5,culp5;locus_tag=Rv1758
AL123456.3	EMBL	CDS	1989042	1989566	.	+	0	ID=cds-CCP44524.1;Parent=gene-Rv1758;Dbxref=EnsemblGenomes-Gn:Rv1758,EnsemblGenomes-Tr:CCP44524,GOA:O06793,InterPro:IPR000675,InterPro:IPR029058,UniProtKB/TrEMBL:O06793,NCBI_GP:CCP44524.1;Name=CCP44524.1;Note=Rv1758%2C (MTCY28.24)%2C len: 174 aa. Probable cut1%2Cserine esterase%2C cutinase family%2C similar to Rv2301|CUT2_MYCTU|Q50664 probable cutinase cy339.08c precursor from Mycobacterium tuberculosis (219 aa)%2C FASTA scores: opt: 369%2C E(): 1. 1e-16%2C (39.1%25 identity in 179 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical cutinases Rv3452%2C Rv1984c%2C Rv3451 and Rv3724. CDS has been interrupted by IS6110 insertion element and 5'-end deleted. Belongs to the cutinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cut1;locus_tag=Rv1758;product=Probable cutinase Cut1;protein_id=CCP44524.1;transl_table=11
AL123456.3	EMBL	gene	1989833	1992577	.	-	.	ID=gene-Rv1759c;Name=wag22;gbkey=Gene;gene=wag22;gene_biotype=protein_coding;locus_tag=Rv1759c
AL123456.3	EMBL	CDS	1989833	1992577	.	-	0	ID=cds-CCP44525.1;Parent=gene-Rv1759c;Dbxref=EnsemblGenomes-Gn:Rv1759c,EnsemblGenomes-Tr:CCP44525,GOA:P9WIG5,InterPro:IPR000084,NCBI_GP:CCP44525.1;Name=CCP44525.1;Note=Rv1759c%2C (MT1807%2C MTCY28.25c)%2C len: 914 aa. Wag22%2Cantigen member (see citations below) of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins%2C highly similar to others e.g. MT1367|Q10637 hypothetical glycine-rich 49.6 kDa protein from Mycobacterium tuberculosis (603 aa)%2C FASTA scores: opt: 2010%2C E(): 0%2C (53.0%25 identity in 724 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=wag22;locus_tag=Rv1759c;product=PE-PGRS family protein Wag22;protein_id=CCP44525.1;transl_table=11
AL123456.3	EMBL	gene	1993153	1994661	.	+	.	ID=gene-Rv1760;Name=Rv1760;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1760
AL123456.3	EMBL	CDS	1993153	1994661	.	+	0	ID=cds-CCP44526.1;Parent=gene-Rv1760;Dbxref=EnsemblGenomes-Gn:Rv1760,EnsemblGenomes-Tr:CCP44526,GOA:P9WKB9,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP44526.1;Name=CCP44526.1;Note=Rv1760%2C (MTCY28.26)%2C len: 502 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C similar to several other Mycobacterium tuberculosis proteins e.g. Q10554|Y895_MYCTU|MTCY31.23 (505 aa)%2C FASTA scores: opt: 692%2C E(): 0%2C (31.7%25 identity in 477 aa overlap). Member of family with at least 15 other members e.g. Rv3740c%2CRv3734c%2C Rv1425%2C etc.;gbkey=CDS;locus_tag=Rv1760;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP44526.1;transl_table=11
AL123456.3	EMBL	gene	1994671	1995054	.	-	.	ID=gene-Rv1761c;Name=Rv1761c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1761c
AL123456.3	EMBL	CDS	1994671	1995054	.	-	0	ID=cds-CCP44527.1;Parent=gene-Rv1761c;Dbxref=EnsemblGenomes-Gn:Rv1761c,EnsemblGenomes-Tr:CCP44527,PDB:2K3M,UniProtKB/TrEMBL:O06796,NCBI_GP:CCP44527.1;Name=CCP44527.1;Note=Rv1761c%2C (MTCY28.27c)%2C len: 127 aa. Possibly exported protein with hydrophobic stretch or TMhelix at aa 15-37.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1761c;product=Possible exported protein;protein_id=CCP44527.1;transl_table=11
AL123456.3	EMBL	gene	1995054	1995842	.	-	.	ID=gene-Rv1762c;Name=Rv1762c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1762c
AL123456.3	EMBL	CDS	1995054	1995842	.	-	0	ID=cds-CCP44528.1;Parent=gene-Rv1762c;Dbxref=EnsemblGenomes-Gn:Rv1762c,EnsemblGenomes-Tr:CCP44528,GOA:O06797,InterPro:IPR002765,UniProtKB/TrEMBL:O06797,NCBI_GP:CCP44528.1;Name=CCP44528.1;Note=Rv1762c%2C (MTCY28.28c)%2C len: 262 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1762c;product=Unknown protein;protein_id=CCP44528.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	1996101	1997455	.	+	.	ID=id-AL123456.3:1996101..1997455;Note=IS6110-4%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-4
AL123456.3	EMBL	repeat_region	1996101	1996128	.	+	.	ID=id-AL123456.3:1996101..1996128;Note=28 bp inverted repeat at the left end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	1996152	1996478	.	+	.	ID=gene-Rv1763;Name=Rv1763;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1763
AL123456.3	EMBL	CDS	1996152	1996478	.	+	0	ID=cds-CCP44529.1;Parent=gene-Rv1763;Dbxref=EnsemblGenomes-Gn:Rv1763,EnsemblGenomes-Tr:CCP44529,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP44529.1;Name=CCP44529.1;Note=Rv1763%2C (MTCY28.29)%2C len: 108 aa. Putative Transposase for IS6110 (fragment)%2C identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion element IS6110 hypothetical 12.0 kDa protein (108 aa)%2C fasta scores: E(): 1.4e-43%2C(100.00%25 identity in 108 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv1763 and Rv1764%2C the sequence UUUUAAAG (directly upstream of Rv1764) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv1763;product=Putative transposase for insertion sequence element IS6110 (fragment);protein_id=CCP44529.1;transl_table=11
AL123456.3	EMBL	gene	1996427	1997413	.	+	.	ID=gene-Rv1764;Name=Rv1764;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1764;partial=true;start_range=.,1996427
AL123456.3	EMBL	CDS	1996427	1997413	.	+	0	ID=cds-CCP44530.1;Parent=gene-Rv1764;Dbxref=EnsemblGenomes-Gn:Rv1764,EnsemblGenomes-Tr:CCP44530,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP44530.1;Name=CCP44530.1;Note=Rv1764%2C (MTCY28.30)%2C len: 328 aa. Putative Transposase for IS6110 insertion element. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv1763 and Rv1764%2Cthe sequence UUUUAAAG (directly upstream of Rv1764) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 34 aa);gbkey=CDS;locus_tag=Rv1764;partial=true;product=Putative transposase;protein_id=CCP44530.1;start_range=.,1996427;transl_table=11
AL123456.3	EMBL	gene	1997418	1998515	.	-	.	ID=gene-Rv1765c;Name=Rv1765c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1765c
AL123456.3	EMBL	CDS	1997418	1998515	.	-	0	ID=cds-CCP44531.1;Parent=gene-Rv1765c;Dbxref=EnsemblGenomes-Gn:Rv1765c,EnsemblGenomes-Tr:CCP44531,GOA:O06798,InterPro:IPR002711,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:O06798,NCBI_GP:CCP44531.1;Name=CCP44531.1;Note=Rv1765c%2C (MTCY28.31c)%2C len: 365 aa. Conserved hypothetical protein%2C highly similar to O53461|Rv2015c|MTV018.02c conserved hypothetical protein (418 aa)%2C (97.8%25 identity in 364 aa overlap). Blast hits with non-is part of sequence submitted under MTU78639.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1765c;product=Conserved hypothetical protein;protein_id=CCP44531.1;transl_table=11
AL123456.3	EMBL	repeat_region	1997428	1997455	.	-	.	ID=id-Rv1765c;Note=28 bp inverted repeat at the right end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC;gbkey=repeat_region;locus_tag=Rv1765c
AL123456.3	EMBL	mobile_genetic_element	1998584	1999813	.	-	.	ID=id-AL123456.3:1998584..1999813;Note=ISB9'%2C len: 1230 nt. Insertion sequence ISB9%2C nearly identical to EM_BA:MTU78639. Note that this sequence shows several differences to EM_BA: MTU78639%2C and the transposase ORFs are extensively frameshifted. Our sequence has been checked and is thought to be correct%3B the sequence in EM_BA:MTU78639 is from a different isolate of Mycobacterium tuberculosis.;gbkey=mobile_element;mobile_element_type=insertion sequence:ISB9'
AL123456.3	EMBL	repeat_region	1998584	1998597	.	+	.	ID=id-AL123456.3:1998584..1998597;Note=14 bp Inverted repeat at the left end of ISB9'%2CATCACCCCGCAAAG;gbkey=repeat_region
AL123456.3	EMBL	gene	1999142	1999357	.	-	.	ID=gene-Rv1765A;Name=Rv1765A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1765A
AL123456.3	EMBL	CDS	1999142	1999357	.	-	0	ID=cds-CCP44532.1;Parent=gene-Rv1765A;Dbxref=EnsemblGenomes-Gn:Rv1765A,EnsemblGenomes-Tr:CCP44532,GOA:Q79FL0,InterPro:IPR012337,UniProtKB/TrEMBL:Q79FL0,NCBI_GP:CCP44532.1;Name=CCP44532.1;Note=Rv1765A%2C len: 71 aa. Putative transposase (fragment)%2C similar to part of many transposase genes including IS6110 e.g. P19774|TRA9_MYCTU putative transposase from Mycobacterium tuberculosis (278 aa)%2C FASTA scores: opt: 231%2C E(): 4.7e-11%2C (45.35%25 identity in 75 aa overlap).;gbkey=CDS;locus_tag=Rv1765A;product=Putative transposase (fragment);protein_id=CCP44532.1;transl_table=11
AL123456.3	EMBL	gene	1999737	2000006	.	+	.	ID=gene-Rv1766;Name=Rv1766;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1766
AL123456.3	EMBL	CDS	1999737	2000006	.	+	0	ID=cds-CCP44533.1;Parent=gene-Rv1766;Dbxref=EnsemblGenomes-Gn:Rv1766,EnsemblGenomes-Tr:CCP44533,InterPro:IPR003735,UniProtKB/TrEMBL:O06799,NCBI_GP:CCP44533.1;Name=CCP44533.1;Note=Rv1766%2C (MTCY28.32)%2C len: 89 aa. Conserved protein%2Chighly similar to P54431|YRKD_BACSU Hypothetical 7.0 kDa protein in bltr-spoIIIC intergenic region from Bacillus subtilis (63 aa)%2C FASTA scores: opt: 151%2C E(): 1.5e-05%2C(53.3%25 identity in 45 aa overlap). Also similar to Q9RD62|SCF56.04C|AL133424 Hypothetical protein from Streptomyces coelicolor (92 aa)%2C FASTA scores: opt: 239%2CE(): 1.3e-11%2C (62.5%25 identity in 64 aa overlap). Also some similarity to other Mycobacterium tuberculosis hypothetical proteins e.g. O07434|Rv0190|MTCI28.29 (96 aa)%2C (35.5%25 identity in 62 aa overlap)%3B P71543|Rv0967 (119 aa)%2C and P71600|Rv0030 (109 aa). Start changed since original submission.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1766;product=Conserved protein;protein_id=CCP44533.1;transl_table=11
AL123456.3	EMBL	repeat_region	1999800	1999813	.	-	.	ID=id-AL123456.3:1999800..1999813;Note=14 bp Inverted repeat at the right end of ISB9%2CATCACCCCGGCAAG;gbkey=repeat_region
AL123456.3	EMBL	gene	2000074	2000433	.	+	.	ID=gene-Rv1767;Name=Rv1767;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1767
AL123456.3	EMBL	CDS	2000074	2000433	.	+	0	ID=cds-CCP44534.1;Parent=gene-Rv1767;Dbxref=EnsemblGenomes-Gn:Rv1767,EnsemblGenomes-Tr:CCP44534,GOA:O06800,InterPro:IPR003779,InterPro:IPR004675,InterPro:IPR029032,UniProtKB/TrEMBL:O06800,NCBI_GP:CCP44534.1;Name=CCP44534.1;Note=Rv1767%2C (MTCY28.33)%2C len: 119 aa. Conserved protein%2Csimilar to Q57498|YA53_HAEIN hypothetical protein HI1053 from Haemophilus influenzae (113 aa)%2C FASTA scores: opt: 233%2C E(): 6.4e-10%2C (40.0%25 identity in 90 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1767;product=Conserved protein;protein_id=CCP44534.1;transl_table=11
AL123456.3	EMBL	gene	2000614	2002470	.	+	.	ID=gene-Rv1768;Name=PE_PGRS31;gbkey=Gene;gene=PE_PGRS31;gene_biotype=protein_coding;locus_tag=Rv1768
AL123456.3	EMBL	CDS	2000614	2002470	.	+	0	ID=cds-CCP44535.1;Parent=gene-Rv1768;Dbxref=EnsemblGenomes-Gn:Rv1768,EnsemblGenomes-Tr:CCP44535,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FK9,NCBI_GP:CCP44535.1;Name=CCP44535.1;Note=Rv1768%2C (MTCY28.34)%2C len: 618 aa. PE_PGRS31%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C 2002)%2C highly similar to Q50615 hypothetical 40.8 kDa protein (498 aa)%2CFASTA scores: opt: 1703%2C E(): 0%2C (57.4%25 identity in 566 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS31;locus_tag=Rv1768;product=PE-PGRS family protein PE_PGRS31;protein_id=CCP44535.1;transl_table=11
AL123456.3	EMBL	gene	2002626	2003870	.	+	.	ID=gene-Rv1769;Name=Rv1769;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1769
AL123456.3	EMBL	CDS	2002626	2003870	.	+	0	ID=cds-CCP44536.1;Parent=gene-Rv1769;Dbxref=EnsemblGenomes-Gn:Rv1769,EnsemblGenomes-Tr:CCP44536,GOA:O06802,InterPro:IPR001608,InterPro:IPR029066,UniProtKB/TrEMBL:O06802,NCBI_GP:CCP44536.1;Name=CCP44536.1;Note=Rv1769%2C (MTCY28.35)%2C len: 414 aa. Conserved protein%2Csimilar to O88066|SCI35.31|AL031541 hypothetical protein from Streptomyces coelicolor (402 aa)%2C FASTA scores: opt: 1341%2C E(): 0%2C (53.8%25 identity in 398 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1769;product=Conserved protein;protein_id=CCP44536.1;transl_table=11
AL123456.3	EMBL	gene	2003878	2005164	.	+	.	ID=gene-Rv1770;Name=Rv1770;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1770
AL123456.3	EMBL	CDS	2003878	2005164	.	+	0	ID=cds-CCP44537.1;Parent=gene-Rv1770;Dbxref=EnsemblGenomes-Gn:Rv1770,EnsemblGenomes-Tr:CCP44537,GOA:O06803,InterPro:IPR007484,UniProtKB/TrEMBL:O06803,NCBI_GP:CCP44537.1;Name=CCP44537.1;Note=Rv1770%2C (MTCY28.36)%2C len: 428 aa. Conserved protein%2Chighly similar in N-terminus to Q49882 Hypothetical protein from Mycobacterium leprae from cosmid L247 (83 aa)%2C FASTA scores: opt: 301%2C E(): 1e-12%2C (56.5%25 identity in 85 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1770;product=Conserved protein;protein_id=CCP44537.1;transl_table=11
AL123456.3	EMBL	gene	2005161	2006447	.	+	.	ID=gene-Rv1771;Name=Rv1771;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1771
AL123456.3	EMBL	CDS	2005161	2006447	.	+	0	ID=cds-CCP44538.1;Parent=gene-Rv1771;Dbxref=EnsemblGenomes-Gn:Rv1771,EnsemblGenomes-Tr:CCP44538,GOA:P9WIT3,InterPro:IPR006093,InterPro:IPR006094,InterPro:IPR007173,InterPro:IPR010032,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,InterPro:IPR023595,NCBI_GP:CCP44538.1;Name=CCP44538.1;Note=Rv1771%2C (MTCY28.37)%2C len: 428 aa. L-gulono-1%2C4-lactone dehydrogenase (See Wolucka and Communi%2C 2006)%2C similar to e.g. GGLO_RAT|P10867 l-gulonolactone oxidase (439 aa)%2C FASTA scores: opt: 862%2CE(): 0%2C (34.1%25 identity in 434 aa overlap). Also shows slight similarity to Mycobacterium tuberculosis oxidoreductase Rv1726|MTCY04C12.11 (22.9%25 identity in 441 aa overlap) and others e.g. Rv3107c%2C Rv1257c%2C Rv2251%2C etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site. Alternative nucleotide at position 2006032 (a->G%3B Q291R) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00862;locus_tag=Rv1771;product=L-gulono-1%2C4-lactone dehydrogenase;protein_id=CCP44538.1;transl_table=11
AL123456.3	EMBL	gene	2006636	2006947	.	+	.	ID=gene-Rv1772;Name=Rv1772;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1772
AL123456.3	EMBL	CDS	2006636	2006947	.	+	0	ID=cds-CCP44539.1;Parent=gene-Rv1772;Dbxref=EnsemblGenomes-Gn:Rv1772,EnsemblGenomes-Tr:CCP44539,GOA:O06805,InterPro:IPR005561,InterPro:IPR011991,InterPro:IPR024189,UniProtKB/TrEMBL:O06805,NCBI_GP:CCP44539.1;Name=CCP44539.1;Note=Rv1772%2C (MTCY28.38)%2C len: 103 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1772;product=Hypothetical protein;protein_id=CCP44539.1;transl_table=11
AL123456.3	EMBL	gene	2007020	2007766	.	-	.	ID=gene-Rv1773c;Name=Rv1773c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1773c
AL123456.3	EMBL	CDS	2007020	2007766	.	-	0	ID=cds-CCP44540.1;Parent=gene-Rv1773c;Dbxref=EnsemblGenomes-Gn:Rv1773c,EnsemblGenomes-Tr:CCP44540,GOA:O06806,InterPro:IPR005471,InterPro:IPR011991,InterPro:IPR014757,InterPro:IPR029016,UniProtKB/TrEMBL:O06806,NCBI_GP:CCP44540.1;Name=CCP44540.1;Note=Rv1773c%2C (MTCY28.39)%2C len: 248 aa. Probable transcriptional regulator belonging to IclR family%2C similar to ICLR_ECOLI|P16528 acetate operon repressor from Escherichia coli (274 aa)%2C FASTA scores: opt: 261%2C E(): 3.3e-10%2C (26.9%25 identity in 249 aa overlap). Also similar to Mycobacterium tuberculosis protein Rv1719|MTCY04C12.04 (40.2%25 identity in 244 aa overlap)%3B and Rv2989. Start site chosen by homology%2C but may extend further upstream. Contains possible helix-turn-helix motif at aa 37-58 (+3.24 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1773c;product=Probable transcriptional regulatory protein;protein_id=CCP44540.1;transl_table=11
AL123456.3	EMBL	gene	2007832	2009172	.	+	.	ID=gene-Rv1774;Name=Rv1774;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1774
AL123456.3	EMBL	CDS	2007832	2009172	.	+	0	ID=cds-CCP44541.1;Parent=gene-Rv1774;Dbxref=EnsemblGenomes-Gn:Rv1774,EnsemblGenomes-Tr:CCP44541,GOA:O33177,InterPro:IPR006093,InterPro:IPR006094,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,UniProtKB/TrEMBL:O33177,NCBI_GP:CCP44541.1;Name=CCP44541.1;Note=Rv1774%2C (MTCY25C11.01)%2C len: 446 aa. Probable oxidoreductase%2C similar to several e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa)%2C FASTA scores: opt: 417%2C E(): 6e-20%2C (28.4%25 identity in 462 aa overlap). Also some similarity to Mycobacterium tuberculosis oxidoreductase MTCY04C12.11 (24.1%25 identity in 444 aa overlap). Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00862;locus_tag=Rv1774;product=Probable oxidoreductase;protein_id=CCP44541.1;transl_table=11
AL123456.3	EMBL	gene	2009172	2009990	.	+	.	ID=gene-Rv1775;Name=Rv1775;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1775
AL123456.3	EMBL	CDS	2009172	2009990	.	+	0	ID=cds-CCP44542.1;Parent=gene-Rv1775;Dbxref=EnsemblGenomes-Gn:Rv1775,EnsemblGenomes-Tr:CCP44542,UniProtKB/TrEMBL:O33178,NCBI_GP:CCP44542.1;Name=CCP44542.1;Note=Rv1775%2C (MTCY25C11.02)%2C unknown%2C len: 272 aa. Conserved hypothetical protein%2C similar to O28806|AF1466 conserved hypothetical protein from Archaeoglobus fulgidus (255 aa)%2C FASTA scores: opt: 364%2C E(): 1e-17%2C (29.2%25 identity in 267 aa overlap).;gbkey=CDS;locus_tag=Rv1775;product=Conserved hypothetical protein;protein_id=CCP44542.1;transl_table=11
AL123456.3	EMBL	gene	2009995	2010555	.	-	.	ID=gene-Rv1776c;Name=Rv1776c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1776c
AL123456.3	EMBL	CDS	2009995	2010555	.	-	0	ID=cds-CCP44543.1;Parent=gene-Rv1776c;Dbxref=EnsemblGenomes-Gn:Rv1776c,EnsemblGenomes-Tr:CCP44543,GOA:O33179,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:O33179,NCBI_GP:CCP44543.1;Name=CCP44543.1;Note=Rv1776c%2C (MTCY25C11.03c)%2C len: 186 aa. Possible regulatory protein%2C some similarity to Mycobacterium tuberculosis Rv1255c|Q11063 hypothetical transcriptional regulator (202 aa)%2C FASTA scores: opt: 270%2C E(): 9.7e-09%2C(28.3%25 identity in 191 aa overlap). Contains possible helix-turn-helix motif at aa 37-58 (+3.49 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1776c;product=Possible transcriptional regulatory protein;protein_id=CCP44543.1;transl_table=11
AL123456.3	EMBL	gene	2010656	2011960	.	+	.	ID=gene-Rv1777;Name=cyp144;gbkey=Gene;gene=cyp144;gene_biotype=protein_coding;locus_tag=Rv1777
AL123456.3	EMBL	CDS	2010656	2011960	.	+	0	ID=cds-CCP44544.1;Parent=gene-Rv1777;Dbxref=EnsemblGenomes-Gn:Rv1777,EnsemblGenomes-Tr:CCP44544,GOA:P9WPL1,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,NCBI_GP:CCP44544.1;Name=CCP44544.1;Note=Rv1777%2C (MT1827%2C MTCY25C11.04)%2C len: 434 aa. Probable cyp144%2C cytochrome p450%2C similar to CPXM_BACME|Q06069 cytochrome p450 (meg) (410 aa)%2C FASTA scores: opt: 435 E(): 2.3e-16%2C (28.8%25 identity in 372 aa overlap). Also similar to several other Mycobacterium tuberculosis p450 genes including Rv0766c%2C Rv2266%2C etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;gbkey=CDS;gene=cyp144;inference=protein motif:PROSITE:PS00086;locus_tag=Rv1777;product=Probable cytochrome P450 144 Cyp144;protein_id=CCP44544.1;transl_table=11
AL123456.3	EMBL	gene	2012081	2012530	.	-	.	ID=gene-Rv1778c;Name=Rv1778c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1778c
AL123456.3	EMBL	CDS	2012081	2012530	.	-	0	ID=cds-CCP44545.1;Parent=gene-Rv1778c;Dbxref=EnsemblGenomes-Gn:Rv1778c,EnsemblGenomes-Tr:CCP44545,UniProtKB/TrEMBL:O33181,NCBI_GP:CCP44545.1;Name=CCP44545.1;Note=Rv1778c%2C (MTCY25C11.05c)%2C len: 149 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1778c;product=Unknown protein;protein_id=CCP44545.1;transl_table=11
AL123456.3	EMBL	gene	2012686	2014479	.	-	.	ID=gene-Rv1779c;Name=Rv1779c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1779c
AL123456.3	EMBL	CDS	2012686	2014479	.	-	0	ID=cds-CCP44546.1;Parent=gene-Rv1779c;Dbxref=EnsemblGenomes-Gn:Rv1779c,EnsemblGenomes-Tr:CCP44546,GOA:O53930,InterPro:IPR025519,UniProtKB/TrEMBL:O53930,NCBI_GP:CCP44546.1;Name=CCP44546.1;Note=Rv1779c%2C (MTV049.01c)%2C len: 597 aa. Possible integral membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1779c;product=Possible integral membrane protein;protein_id=CCP44546.1;transl_table=11
AL123456.3	EMBL	gene	2014699	2015262	.	+	.	ID=gene-Rv1780;Name=Rv1780;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1780
AL123456.3	EMBL	CDS	2014699	2015262	.	+	0	ID=cds-CCP44547.1;Parent=gene-Rv1780;Dbxref=EnsemblGenomes-Gn:Rv1780,EnsemblGenomes-Tr:CCP44547,GOA:O53931,UniProtKB/TrEMBL:O53931,NCBI_GP:CCP44547.1;Name=CCP44547.1;Note=Rv1780%2C (MTV049.02)%2C len: 187 aa. Conserved protein%2Cequivalent to Q49881|ML1380|U00021_2 cosmid L247 from Mycobacterium leprae (187 aa)%2C FASTA scores: opt: 1000%2CE(): 0%2C (82.4%25 identity in 187 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1780;product=Conserved protein;protein_id=CCP44547.1;transl_table=11
AL123456.3	EMBL	gene	2015302	2017476	.	-	.	ID=gene-Rv1781c;Name=malQ;gbkey=Gene;gene=malQ;gene_biotype=protein_coding;locus_tag=Rv1781c
AL123456.3	EMBL	CDS	2015302	2017476	.	-	0	ID=cds-CCP44548.1;Parent=gene-Rv1781c;Dbxref=EnsemblGenomes-Gn:Rv1781c,EnsemblGenomes-Tr:CCP44548,GOA:P9WK23,InterPro:IPR003385,InterPro:IPR013781,InterPro:IPR017853,NCBI_GP:CCP44548.1;Name=CCP44548.1;Note=Rv1781c%2C (MTV049.03c)%2C len: 724 aa. Probable malQ%2C4-alpha-glucanotransferase%2C similar to many%2C e.g. P15977|MALQ_ECOLI 4-alpha-glucanotransferase (694 aa)%2CFASTA scores: opt: 964%2C E(): 0%2C (31.8%25 identity in 694 aa overlap). Belongs to the disproportionating enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=malQ;locus_tag=Rv1781c;product=Probable 4-alpha-glucanotransferase MalQ (amylomaltase) (disproportionating enzyme) (D-enzyme);protein_id=CCP44548.1;transl_table=11
AL123456.3	EMBL	gene	2017740	2019260	.	+	.	ID=gene-Rv1782;Name=eccB5;gbkey=Gene;gene=eccB5;gene_biotype=protein_coding;locus_tag=Rv1782
AL123456.3	EMBL	CDS	2017740	2019260	.	+	0	ID=cds-CCP44549.1;Parent=gene-Rv1782;Dbxref=EnsemblGenomes-Gn:Rv1782,EnsemblGenomes-Tr:CCP44549,GOA:P9WNQ9,InterPro:IPR007795,NCBI_GP:CCP44549.1;Name=CCP44549.1;Note=Rv1782%2C (MTV049.04)%2C len: 506 aa. eccB5%2C esx conserved component%2C ESX-5 type VII secretion system protein%2C probable membrane protein%2C similar to four other Mycobacterium tuberculosis hypothetical membrane proteins e.g. O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa)%2C FASTA scores: opt: 1106%2C E(): 0%2C (41.2%25 identity in 485 aa overlap)%3B Rv0283%2C Rv3450c%2C and Rv3869%2C all located near ESAT-6 family genes. Also similar to O33088|MLCB628.17C|Y14967 cosmid B628 from Mycobacterium leprae (481 aa)%2C (32.7%25 identity in 486 aa overlap)%3B and equivalent to Q9Z5I3|MLCB596.27|AL035472 hypothetical protein from Mycobacterium leprae (506 aa) (82.6%25 identity in 506 aa overlap). Has hydrophobic stretch from aa 54-76. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccB5;locus_tag=Rv1782;product=ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein.;protein_id=CCP44549.1;transl_table=11
AL123456.3	EMBL	gene	2019257	2023432	.	+	.	ID=gene-Rv1783;Name=eccC5;gbkey=Gene;gene=eccC5;gene_biotype=protein_coding;locus_tag=Rv1783
AL123456.3	EMBL	CDS	2019257	2023432	.	+	0	ID=cds-CCP44550.1;Parent=gene-Rv1783;Dbxref=EnsemblGenomes-Gn:Rv1783,EnsemblGenomes-Tr:CCP44550,GOA:P9WNA5,InterPro:IPR002543,InterPro:IPR003593,InterPro:IPR023836,InterPro:IPR023837,InterPro:IPR027417,NCBI_GP:CCP44550.1;Name=CCP44550.1;Note=Rv1783%2C (MTV049.05-MTV049.06)%2C len: 1391 aa. eccC5%2Cesx conserved component%2C ESX-5 type VII secretion system protein%2C probable membrane protein. FtsK/SpoIIIE family protein. Similar to Rv3894c. Member of family of Mycobacterium tuberculosis hypothetical proteins including Rv3447c%2C Rv0284%2C Rv3870%2C Rv1783%2C Rv3871%2C Rv3894c%2C all linked to ESAT-6 family genes. Equivalent to Mycobacterium leprae hypothetical protein Q9Z512|MLCB596.28|AL035472 (1345 aa). Previously annotated as two separate genes eccCa5|Rv1783 and eccCb5|Rv1784%2C now fused due to A:T correction at position 2020563 resulting in *463L. Contains two times PS00017 ATP/GTP-binding site motif A (P-loop). Former Rv1784 - Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccC5;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1783;product=ESX conserved component EccC5. ESX-5 type VII secretion system protein.;protein_id=CCP44550.1;transl_table=11
AL123456.3	EMBL	gene	2023447	2024628	.	-	.	ID=gene-Rv1785c;Name=cyp143;gbkey=Gene;gene=cyp143;gene_biotype=protein_coding;locus_tag=Rv1785c
AL123456.3	EMBL	CDS	2023447	2024628	.	-	0	ID=cds-CCP44551.1;Parent=gene-Rv1785c;Dbxref=EnsemblGenomes-Gn:Rv1785c,EnsemblGenomes-Tr:CCP44551,GOA:P9WPL3,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,NCBI_GP:CCP44551.1;Name=CCP44551.1;Note=Rv1785c%2C (MT1834%2C MTV049.07c)%2C len: 393 aa. Probable cyp143%2C cytochrome P450 (1.14.-.-)%2C similar to many e.g. AE0001|RZAE000101_4 Rhizobium sp. NGR234 (414 aa)%2C FASTA scores: opt: 663%2C E(): 0%2C (32.4%25 identity in 413 aa overlap). Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;gbkey=CDS;gene=cyp143;inference=protein motif:PROSITE:PS00086;locus_tag=Rv1785c;product=Probable cytochrome P450 143 Cyp143;protein_id=CCP44551.1;transl_table=11
AL123456.3	EMBL	gene	2024828	2025031	.	+	.	ID=gene-Rv1786;Name=Rv1786;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1786
AL123456.3	EMBL	CDS	2024828	2025031	.	+	0	ID=cds-CCP44552.1;Parent=gene-Rv1786;Dbxref=EnsemblGenomes-Gn:Rv1786,EnsemblGenomes-Tr:CCP44552,UniProtKB/TrEMBL:O53937,NCBI_GP:CCP44552.1;Name=CCP44552.1;Note=Rv1786%2C (MTV049.08)%2C len: 67 aa. Probable ferredoxin%2C similar to others e.g. X63601|FERS_STRGR ferredoxin from Streptomyces griseus (65 aa)%2C FASTA scores: opt: 140%2C E(): 0.001%2C (38.1%25 identity in 63 aa overlap)%3B T50943 probable ferredoxin DitA from Pseudomonas abietaniphila (78 aa)%3B BAA84714.1|AB017795 ferredoxin from Nocardioides sp. (69 aa)%3B etc. Also similar to Rv0763c|MTCY369.08 from Mycobacterium tuberculosis (68 aa)%2CFASTA score: (30.6%25 identity in 62 aa overlap)%3B and Rv0763c.;gbkey=CDS;locus_tag=Rv1786;product=Probable ferredoxin;protein_id=CCP44552.1;transl_table=11
AL123456.3	EMBL	gene	2025301	2026398	.	+	.	ID=gene-Rv1787;Name=PPE25;gbkey=Gene;gene=PPE25;gene_biotype=protein_coding;locus_tag=Rv1787
AL123456.3	EMBL	CDS	2025301	2026398	.	+	0	ID=cds-CCP44553.1;Parent=gene-Rv1787;Dbxref=EnsemblGenomes-Gn:Rv1787,EnsemblGenomes-Tr:CCP44553,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44553.1;Name=CCP44553.1;Note=Rv1787%2C (MTV049.09)%2C len: 365 aa. PPE25%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa)%2C FASTA scores: opt: 837%2C E(): 0%2C (52.0%25 identity in 406 aa overlap).;gbkey=CDS;gene=PPE25;locus_tag=Rv1787;product=PPE family protein PPE25;protein_id=CCP44553.1;transl_table=11
AL123456.3	EMBL	gene	2026477	2026776	.	+	.	ID=gene-Rv1788;Name=PE18;gbkey=Gene;gene=PE18;gene_biotype=protein_coding;locus_tag=Rv1788
AL123456.3	EMBL	CDS	2026477	2026776	.	+	0	ID=cds-CCP44554.1;Parent=gene-Rv1788;Dbxref=EnsemblGenomes-Gn:Rv1788,EnsemblGenomes-Tr:CCP44554,InterPro:IPR000084,UniProtKB/TrEMBL:L7N649,NCBI_GP:CCP44554.1;Name=CCP44554.1;Note=Rv1788%2C (MTV049.10)%2C len: 99 aa. PE18%2C Member of the Mycobacterium tuberculosis PE family of gly-%2C ala-rich proteins (see citation below)%2C similar to Z93777|MTCI364.07 Mycobacterium tuberculosis cosmid (99 aa)%2C FASTA scores: opt: 414%2C E(): 3.6e-20%2C (72.4%25 identity in 98 aa overlap).;gbkey=CDS;gene=PE18;locus_tag=Rv1788;product=PE family protein PE18;protein_id=CCP44554.1;transl_table=11
AL123456.3	EMBL	gene	2026790	2027971	.	+	.	ID=gene-Rv1789;Name=PPE26;gbkey=Gene;gene=PPE26;gene_biotype=protein_coding;locus_tag=Rv1789
AL123456.3	EMBL	CDS	2026790	2027971	.	+	0	ID=cds-CCP44555.1;Parent=gene-Rv1789;Dbxref=EnsemblGenomes-Gn:Rv1789,EnsemblGenomes-Tr:CCP44555,InterPro:IPR000030,InterPro:IPR022171,UniProtKB/TrEMBL:Q79FK6,NCBI_GP:CCP44555.1;Name=CCP44555.1;Note=Rv1789%2C (MTV049.11)%2C len: 393 aa. PPE26%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C highly similar to others e.g.Z98268|MTCI125.26 Mycobacterium tuberculosis cosmid (385 aa)%2C FASTA score: opt: 1283%2C E(): 0%2C (62.7%25 identity in 408 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE26;locus_tag=Rv1789;product=PPE family protein PPE26;protein_id=CCP44555.1;transl_table=11
AL123456.3	EMBL	gene	2028425	2029477	.	+	.	ID=gene-Rv1790;Name=PPE27;gbkey=Gene;gene=PPE27;gene_biotype=protein_coding;locus_tag=Rv1790
AL123456.3	EMBL	CDS	2028425	2029477	.	+	0	ID=cds-CCP44556.1;Parent=gene-Rv1790;Dbxref=EnsemblGenomes-Gn:Rv1790,EnsemblGenomes-Tr:CCP44556,InterPro:IPR000030,InterPro:IPR022171,UniProtKB/TrEMBL:Q79FK5,NCBI_GP:CCP44556.1;Name=CCP44556.1;Note=Rv1790%2C (MTV049.12)%2C len: 350 aa. PPE27%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich protein%2C similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa)%2C FASTA scores: opt: 849%2C E(): 0%2C (50.0%25 identity in 406 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE27;locus_tag=Rv1790;product=PPE family protein PPE27;protein_id=CCP44556.1;transl_table=11
AL123456.3	EMBL	gene	2029904	2030203	.	+	.	ID=gene-Rv1791;Name=PE19;gbkey=Gene;gene=PE19;gene_biotype=protein_coding;locus_tag=Rv1791
AL123456.3	EMBL	CDS	2029904	2030203	.	+	0	ID=cds-CCP44557.1;Parent=gene-Rv1791;Dbxref=EnsemblGenomes-Gn:Rv1791,EnsemblGenomes-Tr:CCP44557,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FK4,NCBI_GP:CCP44557.1;Name=CCP44557.1;Note=Rv1791%2C (MTV049.13)%2C len: 99 aa. PE19%2C Member of the Mycobacterium tuberculosis PE family%2C but no glycine rich C-terminus (see Brennan %26 Delogu 2002)%2C highly similar to Z93777|MTCI364.07 M.tuberculosis cosmid (99 aa) opt: 430 E(): 2.4e-21%2C (75.5%25 identity in 98 aa overlap).;gbkey=CDS;gene=PE19;locus_tag=Rv1791;product=PE family protein PE19;protein_id=CCP44557.1;transl_table=11
AL123456.3	EMBL	pseudogene	2030347	2030643	.	+	.	ID=gene-Rv1792;Name=esxM;gbkey=Gene;gene=esxM;gene_biotype=pseudogene;gene_synonym=QILSS,TB11.0;locus_tag=Rv1792;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	2030347	2030643	.	+	0	ID=cds-Rv1792;Parent=gene-Rv1792;Note=Rv1792%2C (MTV049.14)%2C len: 98 aa. EsxM%2C ESAT-6 like protein (see Gey Van Pittius et al.%2C 2001)%2C member of Mycobacterium tuberculosis QILSS family of proteins with Rv1038c%2C Rv1197%2C Rv3620c and Rv2347c. Has in-frame stop codon at 18074%2C no error could be found to account for this. Identical (apart from stop codon) to P96363|Rv1038c|MTCY10G2.11 putative ESAT-6 like protein 2 (98 aa)%2C FASTA scores: opt: 389%2C E(): 5.8e-26%2C (100.0%25 identity in 58 aa overlap). Similar protein present in Mycobacterium leprae e.g. Q49946|MLCB1701.06C|AL049191 putative ESAT-6 like protein X (95 aa)%2C FASTA scores: opt: 343%2C E(): 1.6e-17%2C (57.6%25 identity in 92 aa overlap). Seems to belong to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxM;locus_tag=Rv1792;product=ESAT-6 like protein EsxM;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	2030694	2030978	.	+	.	ID=gene-Rv1793;Name=esxN;gbkey=Gene;gene=esxN;gene_biotype=protein_coding;gene_synonym=ES6_5,Mtb9.9A;locus_tag=Rv1793
AL123456.3	EMBL	CDS	2030694	2030978	.	+	0	ID=cds-CCP44559.1;Parent=gene-Rv1793;Dbxref=EnsemblGenomes-Gn:Rv1793,EnsemblGenomes-Tr:CCP44559,GOA:P9WNJ3,InterPro:IPR009416,InterPro:IPR010310,NCBI_GP:CCP44559.1;Name=CCP44559.1;Note=Rv1793%2C (MT1842%2C MTV049.15)%2C len: 94 aa. EsxN%2CESAT-6 like protein (see citation below)%2C almost identical to several mycobacterial proteins of the ESAT-6-like family including P95242|Rv2346c|MTCY98.15C|Z83860 putative ESAT-6 like protein 6 (94 aa)%2C FASTA scores: opt: 610%2C E(): 0%2C(97.9 %25 identity in 94 aa overlap)%3B Rv3619c%2C Rv1037c%2C and Rv1198%2C etc. Also present in Mycobacterium leprae. Seems to belong to the ESAT6 family. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxN;locus_tag=Rv1793;product=Putative ESAT-6 like protein EsxN (ESAT-6 like protein 5);protein_id=CCP44559.1;transl_table=11
AL123456.3	EMBL	gene	2031066	2031968	.	+	.	ID=gene-Rv1794;Name=Rv1794;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1794
AL123456.3	EMBL	CDS	2031066	2031968	.	+	0	ID=cds-CCP44560.1;Parent=gene-Rv1794;Dbxref=EnsemblGenomes-Gn:Rv1794,EnsemblGenomes-Tr:CCP44560,GOA:O53943,InterPro:IPR025734,PDB:4KXR,UniProtKB/TrEMBL:O53943,NCBI_GP:CCP44560.1;Name=CCP44560.1;Note=Rv1794%2C (MTV049.16)%2C len: 300 aa. Conserved protein%2Cslight similarity to Mycobacterium tuberculosis O53694|Rv0289|MTV035.17%2C (295 aa)%2C FASTA scores: opt: 172%2CE(): 0.00083%2C (25.7%25 identity in 261 aa overlap). Equivalent to Mycobacterium leprae hypothetical protein Q9Z5I1|MLCB596.31|AL035472 (300 aa)%2C (88.0%25 identity in 300 aa overlap). Contains PS00211 ABC transporters family signature. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1794;product=Conserved protein;protein_id=CCP44560.1;transl_table=11
AL123456.3	EMBL	gene	2032240	2033751	.	+	.	ID=gene-Rv1795;Name=eccD5;gbkey=Gene;gene=eccD5;gene_biotype=protein_coding;locus_tag=Rv1795
AL123456.3	EMBL	CDS	2032240	2033751	.	+	0	ID=cds-CCP44561.1;Parent=gene-Rv1795;Dbxref=EnsemblGenomes-Gn:Rv1795,EnsemblGenomes-Tr:CCP44561,GOA:P9WNP9,InterPro:IPR006707,InterPro:IPR024962,NCBI_GP:CCP44561.1;Name=CCP44561.1;Note=Rv1795%2C (MTV049.17)%2C len: 503 aa. eccD5%2C esx conserved component%2C ESX-5 type VII secretion system protein%2C probable membrane protein%2C has a hydrophilic stretch from ~~1-130 then very hydrophobic. Similar to several other mycobacterial proteins%2C all linked to ESAT-6 family e.g. Rv3887c|MTY15F10.24|Z94121 (509 aa)%2C FASTA scores: opt: 360%2C E(): 1.6e-15%2C (26.7%25 identity in 514 aa overlap)%3B Rv3448%2C and Rv0290.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccD5;locus_tag=Rv1795;product=ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein.;protein_id=CCP44561.1;transl_table=11
AL123456.3	EMBL	gene	2033729	2035486	.	+	.	ID=gene-Rv1796;Name=mycP5;gbkey=Gene;gene=mycP5;gene_biotype=protein_coding;locus_tag=Rv1796
AL123456.3	EMBL	CDS	2033729	2035486	.	+	0	ID=cds-CCP44562.1;Parent=gene-Rv1796;Dbxref=EnsemblGenomes-Gn:Rv1796,EnsemblGenomes-Tr:CCP44562,GOA:O53945,InterPro:IPR000209,InterPro:IPR015500,InterPro:IPR023827,InterPro:IPR023834,UniProtKB/TrEMBL:O53945,NCBI_GP:CCP44562.1;Name=CCP44562.1;Note=Rv1796%2C (MTV049.18)%2C len: 585 aa. Probable mycP5%2Cpro-rich membrane-anchored serine protease (mycosin) (see citations below). Member of family with four other Mycobacterium tuberculosis serine proteases: Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa)%2C FASTA scores: opt: 1173%2C E(): 0%2C (47.9%25 identity in 578 aa overlap)%3B Rv0291%2C Rv3883c%2C and Rv3449. Genes all linked to those of ESAT-6 family. Has possible N-terminal signal peptide and hydrophobic anchor-like stretch at C-terminus. Contains two serine protease%2C subtilase family active site motifs: a aspartic acid active site motif (PS00136)%3B and a histidine active site motif (PS00137). Belongs to peptidase family S8 (also known as the subtilase family)%2C pyrolysin subfamily. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mycP5;inference=protein motif:PROSITE:PS00137;locus_tag=Rv1796;product=Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5);protein_id=CCP44562.1;transl_table=11
AL123456.3	EMBL	gene	2035483	2036703	.	+	.	ID=gene-Rv1797;Name=eccE5;gbkey=Gene;gene=eccE5;gene_biotype=protein_coding;locus_tag=Rv1797
AL123456.3	EMBL	CDS	2035483	2036703	.	+	0	ID=cds-CCP44563.1;Parent=gene-Rv1797;Dbxref=EnsemblGenomes-Gn:Rv1797,EnsemblGenomes-Tr:CCP44563,GOA:P9WJE3,InterPro:IPR021368,NCBI_GP:CCP44563.1;Name=CCP44563.1;Note=Rv1797%2C (MTV049.19)%2C len: 406 aa. eccE5%2C esx conserved component%2C ESX-5 type VII secretion system protein%2C probable membrane protein%2C some similarity to Mycobacterium tuberculosis O05462|Rv3882c|MTCY15F10.30|Z94121 (462 aa)%2C FASTA scores: opt: 181%2C E(): 9.2e-05%2C (25.4%25 identity in 283 aa overlap). Has two hydrophobic stretch near N-terminus. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccE5;locus_tag=Rv1797;product=ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable membrane protein.;protein_id=CCP44563.1;transl_table=11
AL123456.3	EMBL	gene	2036700	2038532	.	+	.	ID=gene-Rv1798;Name=eccA5;gbkey=Gene;gene=eccA5;gene_biotype=protein_coding;locus_tag=Rv1798
AL123456.3	EMBL	CDS	2036700	2038532	.	+	0	ID=cds-CCP44564.1;Parent=gene-Rv1798;Dbxref=EnsemblGenomes-Gn:Rv1798,EnsemblGenomes-Tr:CCP44564,GOA:P9WPI1,InterPro:IPR000641,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR011990,InterPro:IPR023835,InterPro:IPR027417,NCBI_GP:CCP44564.1;Name=CCP44564.1;Note=Rv1798%2C (MTV049.20)%2C len: 610 aa. eccA5%2C esx conserved component%2C ESX-5 type VII secretion system protein%2C similar to several mycobacterial proteins e.g. O05460|MTCY15F10.28|Rv3884c|Z94121 from M. tuberculosis (619 aa)%2C FASTA scores: opt: 669%2C E(): 0%2C (31.0%25 identity in 549 aa overlap)%3B and O33089|MLCB628.18c|Y14967 from Mycobacterium leprae (573 aa)%2C FASTA scores: opt: 723%2C E(): 0%2C (32.4%25 identity in 568 aa overlap). Also very similar to Rv0282. May belong to the CbxX/CfqX family as last ~~320 aa domain very similar to several family members. Contains ATP/GTP-binding site motif A (P-loop%3B PS00017).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccA5;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1798;product=ESX conserved component EccA5. ESX-5 type VII secretion system protein.;protein_id=CCP44564.1;transl_table=11
AL123456.3	EMBL	gene	2039159	2039350	.	+	.	ID=gene-Rv1799;Name=lppT;gbkey=Gene;gene=lppT;gene_biotype=protein_coding;locus_tag=Rv1799
AL123456.3	EMBL	CDS	2039159	2039350	.	+	0	ID=cds-CCP44565.1;Parent=gene-Rv1799;Dbxref=EnsemblGenomes-Gn:Rv1799,EnsemblGenomes-Tr:CCP44565,UniProtKB/TrEMBL:O53948,NCBI_GP:CCP44565.1;Name=CCP44565.1;Note=Rv1799%2C (MTV049.21)%2C len: 63 aa. Probable lppT lipoprotein%2C has possible signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lppT;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1799;product=Probable lipoprotein LppT;protein_id=CCP44565.1;transl_table=11
AL123456.3	EMBL	gene	2039453	2041420	.	+	.	ID=gene-Rv1800;Name=PPE28;gbkey=Gene;gene=PPE28;gene_biotype=protein_coding;locus_tag=Rv1800
AL123456.3	EMBL	CDS	2039453	2041420	.	+	0	ID=cds-CCP44566.1;Parent=gene-Rv1800;Dbxref=EnsemblGenomes-Gn:Rv1800,EnsemblGenomes-Tr:CCP44566,InterPro:IPR000030,InterPro:IPR013228,InterPro:IPR029058,NCBI_GP:CCP44566.1;Name=CCP44566.1;Note=Rv1800%2C (MTV049.22)%2C len: 655 aa. PPE28%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C C-terminal very similar to parts of PE proteins e.g. Z92770|MTCI5.25|Rv0151c (588 aa)%2C FASTA scores: opt: 1269%2C E(): 0%2C (41.5%25 identity in 591 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=PPE28;locus_tag=Rv1800;product=PPE family protein PPE28;protein_id=CCP44566.1;transl_table=11
AL123456.3	EMBL	gene	2042001	2043272	.	+	.	ID=gene-Rv1801;Name=PPE29;gbkey=Gene;gene=PPE29;gene_biotype=protein_coding;locus_tag=Rv1801
AL123456.3	EMBL	CDS	2042001	2043272	.	+	0	ID=cds-CCP44567.1;Parent=gene-Rv1801;Dbxref=EnsemblGenomes-Gn:Rv1801,EnsemblGenomes-Tr:CCP44567,GOA:P9WI09,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44567.1;Name=CCP44567.1;Note=Rv1801%2C (MTV049.23)%2C len: 423 aa. PPE29%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C most similar to AL022021|MTV049.29|Rv1808 (409 aa)%2C FASTA scores: opt: 1229%2C E(): 0%2C (55.2%25 identity in 422 aa overlap).;gbkey=CDS;gene=PPE29;locus_tag=Rv1801;product=PPE family protein PPE29;protein_id=CCP44567.1;transl_table=11
AL123456.3	EMBL	gene	2043384	2044775	.	+	.	ID=gene-Rv1802;Name=PPE30;gbkey=Gene;gene=PPE30;gene_biotype=protein_coding;locus_tag=Rv1802
AL123456.3	EMBL	CDS	2043384	2044775	.	+	0	ID=cds-CCP44568.1;Parent=gene-Rv1802;Dbxref=EnsemblGenomes-Gn:Rv1802,EnsemblGenomes-Tr:CCP44568,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44568.1;Name=CCP44568.1;Note=Rv1802%2C (MTV049.24)%2C len: 463 aa. PPE30%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C most similar to AL022021|MTV049.30|Rv1809 (468 aa)%2C FASTA scores: opt: 1238%2C E(): 0%2C (51.0%25 identity in 471 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE30;locus_tag=Rv1802;product=PPE family protein PPE30;protein_id=CCP44568.1;transl_table=11
AL123456.3	EMBL	gene	2044923	2046842	.	-	.	ID=gene-Rv1803c;Name=PE_PGRS32;gbkey=Gene;gene=PE_PGRS32;gene_biotype=protein_coding;locus_tag=Rv1803c
AL123456.3	EMBL	CDS	2044923	2046842	.	-	0	ID=cds-CCP44569.1;Parent=gene-Rv1803c;Dbxref=EnsemblGenomes-Gn:Rv1803c,EnsemblGenomes-Tr:CCP44569,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FJ9,NCBI_GP:CCP44569.1;Name=CCP44569.1;Note=Rv1803c%2C (MTV049.25c)%2C len: 639 aa. PE_PGRS32%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below). Most similar to Rv1768|MTCY28.34|Z95890 (618 aa)%2C FASTA scores: opt: 1827%2C E(): 0%2C (53.5%25 identity in 664 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS32;inference=protein motif:PROSITE:PS00583;locus_tag=Rv1803c;product=PE-PGRS family protein PE_PGRS32;protein_id=CCP44569.1;transl_table=11
AL123456.3	EMBL	gene	2047023	2047349	.	-	.	ID=gene-Rv1804c;Name=Rv1804c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1804c
AL123456.3	EMBL	CDS	2047023	2047349	.	-	0	ID=cds-CCP44570.1;Parent=gene-Rv1804c;Dbxref=EnsemblGenomes-Gn:Rv1804c,EnsemblGenomes-Tr:CCP44570,GOA:O53953,InterPro:IPR007969,UniProtKB/TrEMBL:O53953,NCBI_GP:CCP44570.1;Name=CCP44570.1;Note=Rv1804c%2C (MTV049.26c)%2C len: 108 aa. Conserved protein%2C similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (hydrophobic stretch at N-terminus) e.g. O07222|Rv1810|MTCY16F9.04C|Z96073 (118 aa)%2C FASTA scores: opt: 361%2C E(): 2.3e-19%2C (53.5%25 identity in 101 aa overlap)%3B Rv0622%2C Rv1690%2C and Rv3067%2C etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1804c;product=Conserved protein;protein_id=CCP44570.1;transl_table=11
AL123456.3	EMBL	gene	2047687	2048034	.	-	.	ID=gene-Rv1805c;Name=Rv1805c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1805c
AL123456.3	EMBL	CDS	2047687	2048034	.	-	0	ID=cds-CCP44571.1;Parent=gene-Rv1805c;Dbxref=EnsemblGenomes-Gn:Rv1805c,EnsemblGenomes-Tr:CCP44571,GOA:O53954,UniProtKB/TrEMBL:O53954,NCBI_GP:CCP44571.1;Name=CCP44571.1;Note=Rv1805c%2C (MTV049.27c)%2C len: 115 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1805c;product=Hypothetical protein;protein_id=CCP44571.1;transl_table=11
AL123456.3	EMBL	gene	2048072	2048371	.	+	.	ID=gene-Rv1806;Name=PE20;gbkey=Gene;gene=PE20;gene_biotype=protein_coding;locus_tag=Rv1806
AL123456.3	EMBL	CDS	2048072	2048371	.	+	0	ID=cds-CCP44572.1;Parent=gene-Rv1806;Dbxref=EnsemblGenomes-Gn:Rv1806,EnsemblGenomes-Tr:CCP44572,InterPro:IPR000084,UniProtKB/TrEMBL:L7N656,NCBI_GP:CCP44572.1;Name=CCP44572.1;Note=Rv1806%2C (MTV049.28)%2C len: 99 aa. PE20%2C Member of the Mycobacterium tuberculosis PE family of gly-%2C ala-rich proteins (see citation below)%2C most similar to Rv1788|MTV049.10|AL022021 (99 aa)%2C FASTA scores: opt: 334%2CE(): 4.7 e-15%2C (59.8%25 identity in 97 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE20;locus_tag=Rv1806;product=PE family protein PE20;protein_id=CCP44572.1;transl_table=11
AL123456.3	EMBL	gene	2048398	2049597	.	+	.	ID=gene-Rv1807;Name=PPE31;gbkey=Gene;gene=PPE31;gene_biotype=protein_coding;locus_tag=Rv1807;partial=true;start_range=.,2048398
AL123456.3	EMBL	CDS	2048398	2049597	.	+	0	ID=cds-CCP44573.1;Parent=gene-Rv1807;Dbxref=EnsemblGenomes-Gn:Rv1807,EnsemblGenomes-Tr:CCP44573,InterPro:IPR000030,InterPro:IPR022171,UniProtKB/TrEMBL:L0T7Y7,NCBI_GP:CCP44573.1;Name=CCP44573.1;Note=Rv1807%2C (MTV049.29)%2C len: 399 aa. PPE31%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C most similar to Rv1789|MTV049.11|AL022021 (393 aa)%2C FASTA scores: opt: 1169%2C E(): 0%2C (49.5%25 identity in 412 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE31;locus_tag=Rv1807;partial=true;product=PPE family protein PPE31;protein_id=CCP44573.1;start_range=.,2048398;transl_table=11
AL123456.3	EMBL	gene	2049921	2051150	.	+	.	ID=gene-Rv1808;Name=PPE32;gbkey=Gene;gene=PPE32;gene_biotype=protein_coding;locus_tag=Rv1808
AL123456.3	EMBL	CDS	2049921	2051150	.	+	0	ID=cds-CCP44574.1;Parent=gene-Rv1808;Dbxref=EnsemblGenomes-Gn:Rv1808,EnsemblGenomes-Tr:CCP44574,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44574.1;Name=CCP44574.1;Note=Rv1808%2C (MTV049.30)%2C len: 409 aa. PPE32%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C most similar to Rv1800|MTV049.22|AL022021 (655 aa)%2C FASTA scores: opt: 1225%2C E(): 0%2C (55.1%25 identity in 423 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. Nucleotide position 2050913 in the genome sequence has been corrected%2CA:G resulting in E331E.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE32;inference=protein motif:PROSITE:PS00343;locus_tag=Rv1808;product=PPE family protein PPE32;protein_id=CCP44574.1;transl_table=11
AL123456.3	EMBL	gene	2051282	2052688	.	+	.	ID=gene-Rv1809;Name=PPE33;gbkey=Gene;gene=PPE33;gene_biotype=protein_coding;locus_tag=Rv1809
AL123456.3	EMBL	CDS	2051282	2052688	.	+	0	ID=cds-CCP44575.1;Parent=gene-Rv1809;Dbxref=EnsemblGenomes-Gn:Rv1809,EnsemblGenomes-Tr:CCP44575,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP44575.1;Name=CCP44575.1;Note=Rv1809%2C (MTV049.31)%2C len: 468 aa. PPE33%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C most similar to RV1802AL022021|MTV049.23 (463 aa)%2C FASTA scores: opt: 1238%2C E(): 0%2C (51.2%25 identity in 471 aa overlap). Alternative nucleotide at position 2051746 (T->C%3B A155A) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE33;locus_tag=Rv1809;product=PPE family protein PPE33;protein_id=CCP44575.1;transl_table=11
AL123456.3	EMBL	gene	2052933	2053289	.	+	.	ID=gene-Rv1810;Name=Rv1810;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1810
AL123456.3	EMBL	CDS	2052933	2053289	.	+	0	ID=cds-CCP44576.1;Parent=gene-Rv1810;Dbxref=EnsemblGenomes-Gn:Rv1810,EnsemblGenomes-Tr:CCP44576,GOA:O07222,InterPro:IPR007969,UniProtKB/TrEMBL:O07222,NCBI_GP:CCP44576.1;Name=CCP44576.1;Note=Rv1810%2C (MTCY16F9.04c)%2C len: 118 aa. Conserved protein%2C similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (possible N-terminal signal sequence) e.g. O53953|Rv1804c|MTV049.26c|AL022021 (108 aa)%2C FASTA scores: opt: 361%2C E(): 9.6e-17%2C (53.5%25 identity in 101 aa overlap)%3B Rv0622%2C and Rv1690%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1810;product=Conserved protein;protein_id=CCP44576.1;transl_table=11
AL123456.3	EMBL	gene	2053443	2054147	.	+	.	ID=gene-Rv1811;Name=mgtC;gbkey=Gene;gene=mgtC;gene_biotype=protein_coding;locus_tag=Rv1811
AL123456.3	EMBL	CDS	2053443	2054147	.	+	0	ID=cds-CCP44577.1;Parent=gene-Rv1811;Dbxref=EnsemblGenomes-Gn:Rv1811,EnsemblGenomes-Tr:CCP44577,GOA:I6YBN6,InterPro:IPR003416,UniProtKB/TrEMBL:I6YBN6,NCBI_GP:CCP44577.1;Name=CCP44577.1;Note=Rv1811%2C (MTCY16F9.03c)%2C len: 234 aa. Possible mgtC%2Cmagnesium (Mg2+) transport P-type ATPase C (transmembrane protein)%2C highly similar to many e.g. NP_442124.1|NC_000911 Mg2+ transport ATPase from Synechocystis sp. strain PCC 6803 (234 aa)%3B NP_251248.1|NC_002516 probable transport protein from Pseudomonas aeruginosa (230 aa)%3B P22037|ATMC_SALTY|STM3764 magnesium transport ATPase protein C from Salmonella typhimurium (231 aa)%2C FASTA scores: opt: 545%2C E(): 4.1e-30%2C (42.3%25 identity in 220 aa overlap)%3B N-terminus of NP_213315.1|NC_000918 Mg(2+) transport ATPase from Aquifex aeolicus (225 aa)%3B etc. Belongs to the MGTC / SAPB family;gbkey=CDS;gene=mgtC;locus_tag=Rv1811;product=Possible Mg2+ transport P-type ATPase C MgtC;protein_id=CCP44577.1;transl_table=11
AL123456.3	EMBL	gene	2054157	2055359	.	-	.	ID=gene-Rv1812c;Name=Rv1812c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1812c
AL123456.3	EMBL	CDS	2054157	2055359	.	-	0	ID=cds-CCP44578.1;Parent=gene-Rv1812c;Dbxref=EnsemblGenomes-Gn:Rv1812c,EnsemblGenomes-Tr:CCP44578,GOA:P9WJJ1,InterPro:IPR000103,InterPro:IPR001327,InterPro:IPR013027,InterPro:IPR016040,InterPro:IPR023753,NCBI_GP:CCP44578.1;Name=CCP44578.1;Note=Rv1812c%2C (MTCY16F9.02)%2C len: 400 aa. Probable dehydrogenase%2C similar to other dehydrogenases/oxidases e.g. AE001947|AE001947_10 NADH dehydrogenase II of Deinococcus radiodurans (379 aa)%2C FASTA scores: opt: 404%2CE(): 3.4e-18%2C (26.4%25 identity in 363 aa overlap) and DHNA_HAEIN|P44856 nadh dehydrogenase (444 aa)%2C FASTA scores: opt: 200%2C E(): 8.5e-06%2C (23.3%25 identity in 258 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical dehydrogenases Rv0392c%2C and Rv1854c|MTCY359.19 ndh probable NADH dehydrogenase (31.5%25 identity in 321 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1812c;product=Probable dehydrogenase;protein_id=CCP44578.1;transl_table=11
AL123456.3	EMBL	gene	2055681	2056112	.	-	.	ID=gene-Rv1813c;Name=Rv1813c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1813c
AL123456.3	EMBL	CDS	2055681	2056112	.	-	0	ID=cds-CCP44579.1;Parent=gene-Rv1813c;Dbxref=EnsemblGenomes-Gn:Rv1813c,EnsemblGenomes-Tr:CCP44579,InterPro:IPR025240,NCBI_GP:CCP44579.1;Name=CCP44579.1;Note=Rv1813c%2C (MTCY16F9.01)%2C len: 143 aa. Conserved hypothetical protein. Possibly a exported protein with potential N-terminal signal sequence. Similar to Q11050|Rv1269c|MTCY50.13 hypothetical protein from Mycobacterium tuberculosis (124 aa)%2C (42.7%25 identity in 143 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1813c;product=Conserved hypothetical protein;protein_id=CCP44579.1;transl_table=11
AL123456.3	EMBL	gene	2056521	2057423	.	+	.	ID=gene-Rv1814;Name=erg3;gbkey=Gene;gene=erg3;gene_biotype=protein_coding;locus_tag=Rv1814
AL123456.3	EMBL	CDS	2056521	2057423	.	+	0	ID=cds-CCP44580.1;Parent=gene-Rv1814;Dbxref=EnsemblGenomes-Gn:Rv1814,EnsemblGenomes-Tr:CCP44580,GOA:P9WNZ9,InterPro:IPR006694,NCBI_GP:CCP44580.1;Name=CCP44580.1;Note=Rv1814%2C (MTCY1A11.29c)%2C len: 300 aa. Erg3%2Ctransmembrane C-5 sterol desaturase (see *)%2C weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa)%2C FASTA scores: opt: 154%2C E(): 0.0011%2C(22.9%25 identity in 288 aa overlap). Belongs to the sterol desaturase family. [* Note: work of Jackson%2C C.J.%2C Lamb%2CD.C.%2C Kelly%2C D.E.%2C Kelly%2C S.L.%2C Characterization of a sterol delta 5%2C6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ databases].;gbkey=CDS;gene=erg3;locus_tag=Rv1814;product=Membrane-bound C-5 sterol desaturase Erg3 (sterol-C5-desaturase);protein_id=CCP44580.1;transl_table=11
AL123456.3	EMBL	gene	2057528	2058193	.	+	.	ID=gene-Rv1815;Name=Rv1815;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1815
AL123456.3	EMBL	CDS	2057528	2058193	.	+	0	ID=cds-CCP44581.1;Parent=gene-Rv1815;Dbxref=EnsemblGenomes-Gn:Rv1815,EnsemblGenomes-Tr:CCP44581,GOA:P9WLR9,InterPro:IPR009003,NCBI_GP:CCP44581.1;Name=CCP44581.1;Note=Rv1815%2C (MTCY1A11.28c)%2C len: 221 aa. Conserved protein%2C similar to G473456 hypothetical protein from Mycobacterium fortuitum (255 aa)%2C FASTA scores: opt: 182%2CE(): 3.2e-05%2C (29.6%25 identity in 230 aa overlap). Alternative nucleotide at position 2057774 (a->T%3B I83F) has been observed. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1815;product=Conserved protein;protein_id=CCP44581.1;transl_table=11
AL123456.3	EMBL	gene	2058256	2058960	.	+	.	ID=gene-Rv1816;Name=Rv1816;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1816
AL123456.3	EMBL	CDS	2058256	2058960	.	+	0	ID=cds-CCP44582.1;Parent=gene-Rv1816;Dbxref=EnsemblGenomes-Gn:Rv1816,EnsemblGenomes-Tr:CCP44582,GOA:P9WMC9,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,NCBI_GP:CCP44582.1;Name=CCP44582.1;Note=Rv1816%2C (MTCY1A11.27c)%2C len: 234 aa. Possible transcriptional regulatory protein. MEME analysis suggests similarity to putative Mycobacterium tuberculosis transcriptional regulators%2C Rv0653c%2C Rv0681. Contains helix-turn-helix motif at aa 38-59 (+4.30 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1816;product=Possible transcriptional regulatory protein;protein_id=CCP44582.1;transl_table=11
AL123456.3	EMBL	repeat_region	2059441	2059498	.	+	.	ID=id-AL123456.3:2059441..2059498;Note=58 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2059518	2059575	.	+	.	ID=id-AL123456.3:2059518..2059575;Note=58 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	gene	2059595	2061058	.	+	.	ID=gene-Rv1817;Name=Rv1817;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1817
AL123456.3	EMBL	CDS	2059595	2061058	.	+	0	ID=cds-CCP44583.1;Parent=gene-Rv1817;Dbxref=EnsemblGenomes-Gn:Rv1817,EnsemblGenomes-Tr:CCP44583,GOA:Q50616,InterPro:IPR003953,InterPro:IPR027477,UniProtKB/TrEMBL:Q50616,NCBI_GP:CCP44583.1;Name=CCP44583.1;Note=Rv1817%2C (MTCY1A11.26c)%2C len: 487 aa. Possible flavoprotein%2C similar to G746486 flavoprotein subunit of fumarate reductase FAD domain homologue (474 aa)%2C FASTA scores: opt: 223%2C E(): 5.7e-07%2C (24.1%25 identity in 489 aa overlap)%3B and AJ236923|SFR236923_3 soluble fumarate reductase of Shewanella frigidimarina ifcA (588 aa)%2C FASTA scores: opt: 310%2C E(): 2.5e-11%2C (27.3%25 identity in 484 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1817;product=Possible flavoprotein;protein_id=CCP44583.1;transl_table=11
AL123456.3	EMBL	gene	2061178	2062674	.	-	.	ID=gene-Rv1818c;Name=PE_PGRS33;gbkey=Gene;gene=PE_PGRS33;gene_biotype=protein_coding;locus_tag=Rv1818c
AL123456.3	EMBL	CDS	2061178	2062674	.	-	0	ID=cds-CCP44584.1;Parent=gene-Rv1818c;Dbxref=EnsemblGenomes-Gn:Rv1818c,EnsemblGenomes-Tr:CCP44584,GOA:P9WIF5,InterPro:IPR000084,NCBI_GP:CCP44584.1;Name=CCP44584.1;Note=Rv1818c%2C (MTCY1A11.25)%2C len: 498 aa. PE_PGRS33%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins%2C similar to many. Contains 2 x PS00583 pfkB family of carbohydrate kinases signature 1. Supposedly localised to the cell surface (see citations below).;gbkey=CDS;gene=PE_PGRS33;inference=protein motif:PROSITE:PS00583;locus_tag=Rv1818c;product=PE-PGRS family protein PE_PGRS33;protein_id=CCP44584.1;transl_table=11
AL123456.3	EMBL	gene	2062809	2064728	.	-	.	ID=gene-Rv1819c;Name=bacA;gbkey=Gene;gene=bacA;gene_biotype=protein_coding;locus_tag=Rv1819c
AL123456.3	EMBL	CDS	2062809	2064728	.	-	0	ID=cds-CCP44585.1;Parent=gene-Rv1819c;Dbxref=EnsemblGenomes-Gn:Rv1819c,EnsemblGenomes-Tr:CCP44585,GOA:P9WQI9,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR010509,InterPro:IPR011527,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP44585.1;Name=CCP44585.1;Note=Rv1819c%2C (MTCY1A11.24)%2C len: 639 aa. Probable bacA%2Cdrug-transport transmembrane ATP-binding protein ABC transporter (see citation below)%2C equivalent to AL008609|MLCB1788.47 hypothetical ABC transporter from Mycobacterium leprae (638 aa)%2C (74.9%25 identity in 634 aa overlap). Also similar to other transmembrane ATP-binding proteins e.g. Q57335|Y036_HAEIN hypothetical ABC transporter ATP-binding protein from Haemophilus influenzae (592 aa)%2C FASTA scores: opt: 1235%2C E(): 2.8e-61%2C (40.8%25 identity in 623 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bacA;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1819c;product=Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA;protein_id=CCP44585.1;transl_table=11
AL123456.3	EMBL	gene	2064799	2066442	.	+	.	ID=gene-Rv1820;Name=ilvG;gbkey=Gene;gene=ilvG;gene_biotype=protein_coding;locus_tag=Rv1820
AL123456.3	EMBL	CDS	2064799	2066442	.	+	0	ID=cds-CCP44586.1;Parent=gene-Rv1820;Dbxref=EnsemblGenomes-Gn:Rv1820,EnsemblGenomes-Tr:CCP44586,GOA:P9WG39,InterPro:IPR000399,InterPro:IPR011766,InterPro:IPR012000,InterPro:IPR012001,InterPro:IPR029035,InterPro:IPR029061,NCBI_GP:CCP44586.1;Name=CCP44586.1;Note=Rv1820%2C (MTCY1A11.23c)%2C len: 547 aa. Probable ilvG%2Cacetolactate synthase. Equivalent to AL008609|MLCB1788.46c ilvG from Mycobacterium leprae (548 aa) (86.1%25 identity in 548 aa overlap). Similar to ILVB_KLEPN|P27696 (559 aa)%2CFASTA scores: opt: 660%2C E(): 2.9e-34%2C (29.1%25 identity in 549 aa overlap). Also similar to other Mycobacterium tuberculosis Ilv proteins e.g. Rv3003c (ilvB)%2C etc. Contains PS00187 Thiamine pyrophosphate enzymes signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvG;inference=protein motif:PROSITE:PS00187;locus_tag=Rv1820;product=Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS);protein_id=CCP44586.1;transl_table=11
AL123456.3	EMBL	gene	2066457	2068883	.	+	.	ID=gene-Rv1821;Name=secA2;gbkey=Gene;gene=secA2;gene_biotype=protein_coding;locus_tag=Rv1821
AL123456.3	EMBL	CDS	2066457	2068883	.	+	0	ID=cds-CCP44587.1;Parent=gene-Rv1821;Dbxref=EnsemblGenomes-Gn:Rv1821,EnsemblGenomes-Tr:CCP44587,GOA:P9WGP3,InterPro:IPR000185,InterPro:IPR011115,InterPro:IPR011116,InterPro:IPR011130,InterPro:IPR014018,InterPro:IPR020937,InterPro:IPR026389,InterPro:IPR027417,NCBI_GP:CCP44587.1;Name=CCP44587.1;Note=Rv1821%2C (MTCY1A11.22c)%2C len: 808 aa. Possible secA2%2Cpreprotein translocase and ATPase%2C component of secretion apparatus (see Braunstein %26 Belisle 2000)%2C similar to several preprotein translocases e.g. P28366|SECA_BACSU preprotein translocase secA subunit from Bacillus subtilis (841 aa)%2C FASTA scores: opt: 1424%2C E(): 0%2C (35.9%25 identity in 786 aa overlap). Equivalent to AL008609|MLCB1788.45 Preprotein translocase SecA 2 from Mycobacterium leprae (778 aa) (87.1%25 identity in 780 aa overlap). Also similar to Rv3240c|MTCY20B11.15c secA preprotein translocase from Mycobacterium tuberculosis (949 aa). Could be part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c%2C SECD|Rv2587c%2C SECE|Rv0638%2C SECF|Rv2586c%2CSECG|Rv1440 and SECY|Rv0732. Binds ATP.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=secA2;locus_tag=Rv1821;product=Possible preprotein translocase ATPase SecA2;protein_id=CCP44587.1;transl_table=11
AL123456.3	EMBL	gene	2069080	2069709	.	+	.	ID=gene-Rv1822;Name=pgsA2;gbkey=Gene;gene=pgsA2;gene_biotype=protein_coding;locus_tag=Rv1822
AL123456.3	EMBL	CDS	2069080	2069709	.	+	0	ID=cds-CCP44588.1;Parent=gene-Rv1822;Dbxref=EnsemblGenomes-Gn:Rv1822,EnsemblGenomes-Tr:CCP44588,GOA:P9WPG5,InterPro:IPR000462,InterPro:IPR004570,NCBI_GP:CCP44588.1;Name=CCP44588.1;Note=Rv1822%2C (MTCY1A11.21c)%2C len: 209 aa. Probable pgsA2%2CCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase (see citation below)%2C integral membrane protein%2C equivalent to AL008609|MLCB1788_17 phosphatidyltransferase from Mycobacterium leprae (206 aa)%2CFASTA score: (76.6%25 identity in 205 aa overlap). Also highly similar or similar to others e.g. CAB88885.1|AL353861 putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Streptomyces coelicolor (215 aa)%3B AAC44003.1|U29587 phosphatidylglycerol phosphate synthase from Rhodobacter sphaeroides (227 aa)%3B NP_405431.1|NC_003143 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Yersinia pestis (182 aa)%3B P06978|PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli (181 aa)%2CFASTA scores: opt: 252%2C E(): 2.8e-09%2C (29.7%25 identity in 175 aa overlap)%3B etc. Also similar to Rv2746c|PGSA3|MTV002.11c CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGP synthase) from Mycobacterium tuberculosis (209 aa). Contains PS00379 CDP-alcohol phosphatidyltransferases signature%3B and PS00075 Dihydrofolate reductase signature. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pgsA2;inference=protein motif:PROSITE:PS00379;locus_tag=Rv1822;product=Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA2 (PGP synthase) (phosphatidylglycerophosphate synthase) (3-phosphatidyl-1'-glycerol-3'phosphate synthase);protein_id=CCP44588.1;transl_table=11
AL123456.3	EMBL	gene	2069702	2070625	.	+	.	ID=gene-Rv1823;Name=Rv1823;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1823
AL123456.3	EMBL	CDS	2069702	2070625	.	+	0	ID=cds-CCP44589.1;Parent=gene-Rv1823;Dbxref=EnsemblGenomes-Gn:Rv1823,EnsemblGenomes-Tr:CCP44589,GOA:P9WFG1,InterPro:IPR010273,NCBI_GP:CCP44589.1;Name=CCP44589.1;Note=Rv1823%2C (MTCY01A11.20)%2C len: 307 aa. Conserved protein%2C similar to P71582|MTCY10H4.12|RV0012 hypothetical protein CY10H4.12 from Mycobacterium tuberculosis (262 aa)%2CFASTA scores: opt: 304%2C E(): 1.5e-12%2C (30.1%25 identity in 246 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1823;product=Conserved protein;protein_id=CCP44589.1;transl_table=11
AL123456.3	EMBL	gene	2070654	2071019	.	+	.	ID=gene-Rv1824;Name=Rv1824;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1824
AL123456.3	EMBL	CDS	2070654	2071019	.	+	0	ID=cds-CCP44590.1;Parent=gene-Rv1824;Dbxref=EnsemblGenomes-Gn:Rv1824,EnsemblGenomes-Tr:CCP44590,GOA:P9WLR7,InterPro:IPR009709,NCBI_GP:CCP44590.1;Name=CCP44590.1;Note=Rv1824%2C (MTCY1A11.19c)%2C len: 121 aa. Conserved hypothetical membrane protein similar to P28265|SBP_BACSU sbp protein from Bacillus subtilis (121 aa)%2C FASTA scores: opt: 261%2C E(): 1.9e-12%2C (38.9%25 identity in 113 aa overlap).;gbkey=CDS;locus_tag=Rv1824;product=Conserved hypothetical membrane protein;protein_id=CCP44590.1;transl_table=11
AL123456.3	EMBL	gene	2071036	2071914	.	+	.	ID=gene-Rv1825;Name=Rv1825;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1825
AL123456.3	EMBL	CDS	2071036	2071914	.	+	0	ID=cds-CCP44591.1;Parent=gene-Rv1825;Dbxref=EnsemblGenomes-Gn:Rv1825,EnsemblGenomes-Tr:CCP44591,GOA:P9WFG3,InterPro:IPR010273,PDB:3GMG,NCBI_GP:CCP44591.1;Name=CCP44591.1;Note=Rv1825%2C (MTCY1A11.18c)%2C len: 292 aa. Conserved protein%2C weak similarity to Mycobacterium tuberculosis hypothetical proteins Q50610|MTCY1A11.20C|Rv1823|Z78020 (307 aa)%2C FASTA scores: opt: 182%2C E(): 0.00044%2C (29.9%25 identity in 204 aa overlap)%3B and Rv0012. Has a hydrophobic stretch%2C TMhelix from aa 67 to 85.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1825;product=Conserved protein;protein_id=CCP44591.1;transl_table=11
AL123456.3	EMBL	gene	2071952	2072356	.	+	.	ID=gene-Rv1826;Name=gcvH;gbkey=Gene;gene=gcvH;gene_biotype=protein_coding;locus_tag=Rv1826
AL123456.3	EMBL	CDS	2071952	2072356	.	+	0	ID=cds-CCP44592.1;Parent=gene-Rv1826;Dbxref=EnsemblGenomes-Gn:Rv1826,EnsemblGenomes-Tr:CCP44592,GOA:P9WN55,InterPro:IPR002930,InterPro:IPR003016,InterPro:IPR011053,InterPro:IPR017453,PDB:3HGB,PDB:3IFT,NCBI_GP:CCP44592.1;Name=CCP44592.1;Note=Rv1826%2C (MTCY1A11.17c)%2C len: 134 aa. Probable gcvH%2Cglycine cleavage system H protein%2C highly similar to GCSH_ECOLI|P23884 glycine cleavage system H protein from Escherichia coli (129 aa)%2C FASTA scores: opt: 428%2C E(): 2.2e-22%2C (47.8%25 identity in 134 aa overlap). Equivalent to MLCB1788.37c gcvH from Mycobacterium leprae (78.4%25 identity in 134 aa overlap). Contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. Belongs to the GcvH family.;gbkey=CDS;gene=gcvH;inference=protein motif:PROSITE:PS00189;locus_tag=Rv1826;product=Probable glycine cleavage system H protein GcvH;protein_id=CCP44592.1;transl_table=11
AL123456.3	EMBL	gene	2072596	2073084	.	+	.	ID=gene-Rv1827;Name=garA;gbkey=Gene;gene=garA;gene_biotype=protein_coding;gene_synonym=cfp17;locus_tag=Rv1827
AL123456.3	EMBL	CDS	2072596	2073084	.	+	0	ID=cds-CCP44593.1;Parent=gene-Rv1827;Dbxref=EnsemblGenomes-Gn:Rv1827,EnsemblGenomes-Tr:CCP44593,GOA:P9WJA9,InterPro:IPR000253,InterPro:IPR008984,PDB:2KFU,NCBI_GP:CCP44593.1;Name=CCP44593.1;Note=Rv1827%2C (MTCY1A11.16c)%2C len: 162 aa. GarA%2C conserved protein with forkhead-associated domain at C-terminus (see citation below)%2C equivalent to O32919|MLCB1788.36c hypothetical protein from Mycobacterium leprae (162 aa)%2CFASTA scores: opt: 888%2C E(): 0%2C (87.0%25 identity in 161 aa overlap). Putative physiological substrate of PknB and PknG.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=garA;locus_tag=Rv1827;product=Conserved protein with FHA domain%2C GarA;protein_id=CCP44593.1;transl_table=11
AL123456.3	EMBL	gene	2073081	2073824	.	+	.	ID=gene-Rv1828;Name=Rv1828;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1828
AL123456.3	EMBL	CDS	2073081	2073824	.	+	0	ID=cds-CCP44594.1;Parent=gene-Rv1828;Dbxref=EnsemblGenomes-Gn:Rv1828,EnsemblGenomes-Tr:CCP44594,GOA:P9WME7,InterPro:IPR000551,InterPro:IPR009061,NCBI_GP:CCP44594.1;Name=CCP44594.1;Note=Rv1828%2C (MTCY1A11.15c)%2C len: 247 aa. Conserved protein%2C equivalent to O32918|MLCB1788.35c|AL008609 hypothetical protein from Mycobacterium leprae (251 aa)%2CFASTA scores: opt: 1397%2C E(): 0%2C (87.6%25 identity in 251 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1828;product=Conserved protein;protein_id=CCP44594.1;transl_table=11
AL123456.3	EMBL	gene	2073943	2074437	.	+	.	ID=gene-Rv1829;Name=Rv1829;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1829
AL123456.3	EMBL	CDS	2073943	2074437	.	+	0	ID=cds-CCP44595.1;Parent=gene-Rv1829;Dbxref=EnsemblGenomes-Gn:Rv1829,EnsemblGenomes-Tr:CCP44595,GOA:P9WLR5,InterPro:IPR003729,NCBI_GP:CCP44595.1;Name=CCP44595.1;Note=Rv1829%2C (MTCY1A11.14c)%2C len: 164 aa. Conserved protein%2C equivalent to O32917|MLCB1788.34|AL008609 Hypothetical protein from Mycobacterium leprae (164 aa)%2CFASTA scores: opt: 1011%2C E(): 0%2C (95.1%25 identity in 164 aa overlap). Also present in Aquifex aeolicus%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1829;product=Conserved protein;protein_id=CCP44595.1;transl_table=11
AL123456.3	EMBL	gene	2074841	2075518	.	+	.	ID=gene-Rv1830;Name=Rv1830;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1830
AL123456.3	EMBL	CDS	2074841	2075518	.	+	0	ID=cds-CCP44596.1;Parent=gene-Rv1830;Dbxref=EnsemblGenomes-Gn:Rv1830,EnsemblGenomes-Tr:CCP44596,GOA:P9WME5,InterPro:IPR000551,InterPro:IPR009061,NCBI_GP:CCP44596.1;Name=CCP44596.1;Note=Rv1830%2C (MTCY1A11.13c)%2C len: 225 aa. Conserved hypothetical protein%2C equivalent to Mycobacterium leprae hypothetical protein MLCB1788.33c|AL008609|O32916 (231 aa)%2CFASTA scores: opt: 1307%2C E(): 0%2C (89.6%25 identity in 231 aa overlap).;gbkey=CDS;locus_tag=Rv1830;product=Conserved hypothetical protein;protein_id=CCP44596.1;transl_table=11
AL123456.3	EMBL	gene	2075571	2075828	.	+	.	ID=gene-Rv1831;Name=Rv1831;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1831
AL123456.3	EMBL	CDS	2075571	2075828	.	+	0	ID=cds-CCP44597.1;Parent=gene-Rv1831;Dbxref=EnsemblGenomes-Gn:Rv1831,EnsemblGenomes-Tr:CCP44597,NCBI_GP:CCP44597.1;Name=CCP44597.1;Note=Rv1831%2C (MTCY1A11.12c)%2C len: 85 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1831;product=Hypothetical protein;protein_id=CCP44597.1;transl_table=11
AL123456.3	EMBL	gene	2075877	2078702	.	+	.	ID=gene-Rv1832;Name=gcvB;gbkey=Gene;gene=gcvB;gene_biotype=protein_coding;locus_tag=Rv1832
AL123456.3	EMBL	CDS	2075877	2078702	.	+	0	ID=cds-CCP44598.1;Parent=gene-Rv1832;Dbxref=EnsemblGenomes-Gn:Rv1832,EnsemblGenomes-Tr:CCP44598,GOA:P9WN53,InterPro:IPR003437,InterPro:IPR015421,InterPro:IPR015424,InterPro:IPR020580,InterPro:IPR020581,NCBI_GP:CCP44598.1;Name=CCP44598.1;Note=Rv1832%2C (MTCY1A11.11c)%2C len: 941 aa. Probable gcvB%2Cglycine dehydrogenase [decarboxylating]%2C highly similar to GCSP_ECOLI|P33195 glycine dehydrogenase (decarboxylating) from Escherichia coli (957 aa)%2C FASTA scores: opt: 2194%2CE(): 0%2C (55.4%25 identity in 961 aa overlap). The glycine cleavage system is composed of four proteins: P%2C T%2C L%2C and H;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gcvB;locus_tag=Rv1832;product=Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein);protein_id=CCP44598.1;transl_table=11
AL123456.3	EMBL	gene	2078929	2079789	.	-	.	ID=gene-Rv1833c;Name=Rv1833c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1833c
AL123456.3	EMBL	CDS	2078929	2079789	.	-	0	ID=cds-CCP44599.1;Parent=gene-Rv1833c;Dbxref=EnsemblGenomes-Gn:Rv1833c,EnsemblGenomes-Tr:CCP44599,GOA:P9WMS1,InterPro:IPR000073,InterPro:IPR000639,InterPro:IPR023489,InterPro:IPR029058,NCBI_GP:CCP44599.1;Name=CCP44599.1;Note=Rv1833c%2C (MTCY1A11.10)%2C len: 286 aa. Possible haloalkane dehalogenase. Similar to several haloalkane dehalogenase e.g. CAB45532.1|AJ243259 from Mycobacterium bovis (300 aa)%3B also similar to LINB_PSEPA|P51698 1%2C3%2C4%2C6-tetrachloro-1%2C4-cyclohexadien from Pseudomonas paucimobilis (295 aa)%2C FASTA scores: opt: 314%2C E(): 1.5e-13%2C (33.1%25 identity in 281 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1833c;product=Possible haloalkane dehalogenase;protein_id=CCP44599.1;transl_table=11
AL123456.3	EMBL	gene	2079830	2080696	.	+	.	ID=gene-Rv1834;Name=lipZ;gbkey=Gene;gene=lipZ;gene_biotype=protein_coding;locus_tag=Rv1834
AL123456.3	EMBL	CDS	2079830	2080696	.	+	0	ID=cds-CCP44600.1;Parent=gene-Rv1834;Dbxref=EnsemblGenomes-Gn:Rv1834,EnsemblGenomes-Tr:CCP44600,GOA:P9WLR1,InterPro:IPR000639,InterPro:IPR029058,NCBI_GP:CCP44600.1;Name=CCP44600.1;Note=Rv1834%2C (MTCY1A11.09c)%2C len: 288 aa. Probable lipZ%2Chydrolase%2C some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa)%2C FASTA scores: opt: 507%2C E(): 7.6e-28%2C (33.0%25 identity in 300 aa overlap).;gbkey=CDS;gene=lipZ;locus_tag=Rv1834;product=Probable hydrolase;protein_id=CCP44600.1;transl_table=11
AL123456.3	EMBL	gene	2080701	2082587	.	-	.	ID=gene-Rv1835c;Name=Rv1835c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1835c
AL123456.3	EMBL	CDS	2080701	2082587	.	-	0	ID=cds-CCP44601.1;Parent=gene-Rv1835c;Dbxref=EnsemblGenomes-Gn:Rv1835c,EnsemblGenomes-Tr:CCP44601,GOA:P9WIQ9,InterPro:IPR000383,InterPro:IPR005674,InterPro:IPR008979,InterPro:IPR013736,InterPro:IPR029058,NCBI_GP:CCP44601.1;Name=CCP44601.1;Note=Rv1835c%2C (MTCY1A11.08)%2C len: 628 aa. Conserved hypothetical protein%2C some similarity to putative acylases e.g. G216374 glutaryl 7-aca acylase precursor (634 aa) FASTA scores%2C opt: 202%2C E(): 3.5e-06%2C (25.1%25 identity in 669 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2800 and Rv1215c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1835c;product=Conserved hypothetical protein;protein_id=CCP44601.1;transl_table=11
AL123456.3	EMBL	gene	2082603	2084636	.	-	.	ID=gene-Rv1836c;Name=Rv1836c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1836c
AL123456.3	EMBL	CDS	2082603	2084636	.	-	0	ID=cds-CCP44602.1;Parent=gene-Rv1836c;Dbxref=EnsemblGenomes-Gn:Rv1836c,EnsemblGenomes-Tr:CCP44602,GOA:P9WLQ9,InterPro:IPR002035,NCBI_GP:CCP44602.1;Name=CCP44602.1;Note=Rv1836c%2C (MTCY1A11.07)%2C len: 677 aa. Conserved protein. Equivalent to MLCB1788.28|AL008609 hypothetical protein from Mycobacterium leprae (710 aa)%2C FASTA scores: opt: 2938%2C E(): 0%2C (66.0%25 identity in 714 aa overlap). Contains PS00036 bZIP transcription factors basic domain signature. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00036;locus_tag=Rv1836c;product=Conserved protein;protein_id=CCP44602.1;transl_table=11
AL123456.3	EMBL	gene	2084756	2086981	.	-	.	ID=gene-Rv1837c;Name=glcB;gbkey=Gene;gene=glcB;gene_biotype=protein_coding;locus_tag=Rv1837c
AL123456.3	EMBL	CDS	2084756	2086981	.	-	0	ID=cds-CCP44603.1;Parent=gene-Rv1837c;Dbxref=EnsemblGenomes-Gn:Rv1837c,EnsemblGenomes-Tr:CCP44603,GOA:P9WK17,InterPro:IPR001465,InterPro:IPR006253,InterPro:IPR011076,InterPro:IPR023310,PDB:2GQ3,PDB:3S9I,PDB:3S9Z,PDB:3SAD,PDB:3SAZ,PDB:3SB0,NCBI_GP:CCP44603.1;Name=CCP44603.1;Note=Rv1837c%2C (MTCY1A11.06)%2C len: 741 aa. glcB%2C malate synthase G (see citations below)%2C highly similar to MASY_CORGL|P42450 malate synthase (738 aa)%2C FASTA score: opt: 2961%2C E(): 0%2C (61.3%25 identity in 724 aa overlap). Belongs to the malate synthase G family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glcB;locus_tag=Rv1837c;product=Malate synthase G GlcB;protein_id=CCP44603.1;transl_table=11
AL123456.3	EMBL	gene	2087257	2087652	.	-	.	ID=gene-Rv1838c;Name=vapC13;gbkey=Gene;gene=vapC13;gene_biotype=protein_coding;locus_tag=Rv1838c
AL123456.3	EMBL	CDS	2087257	2087652	.	-	0	ID=cds-CCP44604.1;Parent=gene-Rv1838c;Dbxref=EnsemblGenomes-Gn:Rv1838c,EnsemblGenomes-Tr:CCP44604,GOA:P9WFA1,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44604.1;Name=CCP44604.1;Note=Rv1838c%2C (MTCY359.35)%2C len: 131 aa. Possible vapC13%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1839c%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Part of 14-membered Mycobacterium tuberculosis protein family with Rv2863|MTV003.09|AL008883 (126 aa)%2C FASTA scores: opt: 293%2C E(): 1.5e-14%2C (38.2%25 identity in 123 aa overlap)%3B Rv0749%2C Rv0277c%2C Rv2530c%2C etc. Also similar to AJ248288|CNSPAX06_181 Pyrococcus abyssi complete genome (136 aa)%2C FASTA scores: opt: 197%2C E(): 2.2e-07%2C (33. 1%25 identity in 133 aa overlap).;gbkey=CDS;gene=vapC13;locus_tag=Rv1838c;product=Possible toxin VapC13;protein_id=CCP44604.1;transl_table=11
AL123456.3	EMBL	gene	2087649	2087912	.	-	.	ID=gene-Rv1839c;Name=vapB13;gbkey=Gene;gene=vapB13;gene_biotype=protein_coding;locus_tag=Rv1839c
AL123456.3	EMBL	CDS	2087649	2087912	.	-	0	ID=cds-CCP44605.1;Parent=gene-Rv1839c;Dbxref=EnsemblGenomes-Gn:Rv1839c,EnsemblGenomes-Tr:CCP44605,NCBI_GP:CCP44605.1;Name=CCP44605.1;Note=Rv1839c%2C (MTCY359.34)%2C len: 87 aa. Possible vapB13%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1838c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Some similarity to others in M. tuberculosis e.g. Rv0239%2CRv0662c;gbkey=CDS;gene=vapB13;locus_tag=Rv1839c;product=Possible antitoxin VapB13;protein_id=CCP44605.1;transl_table=11
AL123456.3	EMBL	gene	2087971	2089518	.	-	.	ID=gene-Rv1840c;Name=PE_PGRS34;gbkey=Gene;gene=PE_PGRS34;gene_biotype=protein_coding;locus_tag=Rv1840c
AL123456.3	EMBL	CDS	2087971	2089518	.	-	0	ID=cds-CCP44606.1;Parent=gene-Rv1840c;Dbxref=EnsemblGenomes-Gn:Rv1840c,EnsemblGenomes-Tr:CCP44606,GOA:P9WIF3,InterPro:IPR000084,NCBI_GP:CCP44606.1;Name=CCP44606.1;Note=Rv1840c%2C (MTCY359.33)%2C len: 515 aa. PE_PGRS34%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below). Similar to many e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa)%2C FASTA scores: opt: 1693%2C E(): 0%2C (53.1%25 identity in 612 aa overlap)%3B etc.;gbkey=CDS;gene=PE_PGRS34;locus_tag=Rv1840c;product=PE-PGRS family protein PE_PGRS34;protein_id=CCP44606.1;transl_table=11
AL123456.3	EMBL	gene	2089681	2090718	.	-	.	ID=gene-Rv1841c;Name=Rv1841c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1841c
AL123456.3	EMBL	CDS	2089681	2090718	.	-	0	ID=cds-CCP44607.1;Parent=gene-Rv1841c;Dbxref=EnsemblGenomes-Gn:Rv1841c,EnsemblGenomes-Tr:CCP44607,GOA:P9WLQ7,InterPro:IPR000644,InterPro:IPR002550,NCBI_GP:CCP44607.1;Name=CCP44607.1;Note=Rv1841c%2C (MTCY359.32)%2C len: 345 aa. Conserved hypothetical membrane protein. Some similarity to O07585|YHDP_BACSU hypothetical 49.9 kDa protein from Bacillus subtilis (444 aa)%2C FASTA scores: opt: 620%2C E(): 0%2C(31.1%25 identity in 350 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv1842c%2C Rv2366c.;gbkey=CDS;locus_tag=Rv1841c;product=Conserved hypothetical membrane protein;protein_id=CCP44607.1;transl_table=11
AL123456.3	EMBL	gene	2090718	2092085	.	-	.	ID=gene-Rv1842c;Name=Rv1842c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1842c
AL123456.3	EMBL	CDS	2090718	2092085	.	-	0	ID=cds-CCP44608.1;Parent=gene-Rv1842c;Dbxref=EnsemblGenomes-Gn:Rv1842c,EnsemblGenomes-Tr:CCP44608,GOA:P9WFP3,InterPro:IPR000644,InterPro:IPR002550,InterPro:IPR005170,InterPro:IPR016166,InterPro:IPR016169,NCBI_GP:CCP44608.1;Name=CCP44608.1;Note=Rv1842c%2C (MTCY359.31)%2C len: 455 aa. Conserved hypothetical membrane protein. Similar to Z99109|0O7589 Potential integral membrane protein from Bacillus subtilis (461 aa)%2C FASTA scores: opt: 723%2C E(): 0%2C (31.2%25 identity in 449 aa overlap). Similar to other Mycobacterium tuberculosis putative integral membrane proteins e.g. Rv2366c%2C Rv1841c.;gbkey=CDS;locus_tag=Rv1842c;product=Conserved hypothetical membrane protein;protein_id=CCP44608.1;transl_table=11
AL123456.3	EMBL	gene	2092259	2093698	.	-	.	ID=gene-Rv1843c;Name=guaB1;gbkey=Gene;gene=guaB1;gene_biotype=protein_coding;locus_tag=Rv1843c
AL123456.3	EMBL	CDS	2092259	2093698	.	-	0	ID=cds-CCP44609.1;Parent=gene-Rv1843c;Dbxref=EnsemblGenomes-Gn:Rv1843c,EnsemblGenomes-Tr:CCP44609,GOA:P9WKI3,InterPro:IPR000644,InterPro:IPR001093,InterPro:IPR005990,InterPro:IPR005991,InterPro:IPR013785,NCBI_GP:CCP44609.1;Name=CCP44609.1;Note=Rv1843c%2C (MTCY359.30)%2C len: 479 aa. Probable guaB1%2Cinosine-5'-monophosphate dehydrogenase. Similar to others e.g. IMDH_BACSU|P21879 from Bacillus subtilis (513 aa)%2CFASTA score: opt: 904%2C E(): 0%2C (37.8%25 identity in 471 aa overlap). Similar to other Mycobacterium tuberculosis proteins e.g. guaB2%2C Rv3411c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=guaB1;locus_tag=Rv1843c;product=Probable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD);protein_id=CCP44609.1;transl_table=11
AL123456.3	EMBL	gene	2093731	2095188	.	-	.	ID=gene-Rv1844c;Name=gnd1;gbkey=Gene;gene=gnd1;gene_biotype=protein_coding;locus_tag=Rv1844c
AL123456.3	EMBL	CDS	2093731	2095188	.	-	0	ID=cds-CCP44610.1;Parent=gene-Rv1844c;Dbxref=EnsemblGenomes-Gn:Rv1844c,EnsemblGenomes-Tr:CCP44610,GOA:Q79FJ2,InterPro:IPR006113,InterPro:IPR006114,InterPro:IPR006115,InterPro:IPR006184,InterPro:IPR008927,InterPro:IPR012284,InterPro:IPR013328,InterPro:IPR016040,UniProtKB/TrEMBL:Q79FJ2,NCBI_GP:CCP44610.1;Name=CCP44610.1;Note=Rv1844c%2C (MTCY359.29)%2C len: 485 aa. Probable gnd1%2C6-phosphogluconate dehydrogenase. Similar to others e.g. 6PGD_ECOLI|P00350 from Escherichia coli (468 aa)%2C FASTA scores: opt: 1661%2C E(): 0%2C (53.6%25 identity in 466 aa overlap)%3B etc. Also similar to Rv1122|MTCY22G8.11|gnd2 probable 6-phosphogluconate dehydrogenase%2C decarboxylating from Mycobacterium tuberculosis (340 aa)%2C FASTA score: (33.0%25 identity in 351 aa overlap). Note that Rv1844c is most similar to gnd's from Gram negative organisms%2C while Rv1122|MTCY22G8.11|gnd2 is most similar to gnd's from Gram positive organisms. Belongs to the 6-phosphogluconate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gnd1;locus_tag=Rv1844c;product=Probable 6-phosphogluconate dehydrogenase Gnd1;protein_id=CCP44610.1;transl_table=11
AL123456.3	EMBL	gene	2095218	2096168	.	-	.	ID=gene-Rv1845c;Name=blaR;gbkey=Gene;gene=blaR;gene_biotype=protein_coding;locus_tag=Rv1845c
AL123456.3	EMBL	CDS	2095218	2096168	.	-	0	ID=cds-CCP44611.1;Parent=gene-Rv1845c;Dbxref=EnsemblGenomes-Gn:Rv1845c,EnsemblGenomes-Tr:CCP44611,GOA:P95164,InterPro:IPR001915,UniProtKB/TrEMBL:P95164,NCBI_GP:CCP44611.1;Name=CCP44611.1;Note=Rv1845c%2C (MTCY359.28)%2C len: 316 aa. Possible blaR%2Csensor-transducer protein. Conserved hypothetical transmembrane protein. Equivalent to MLCB1788.18|AL008609 Hypothetical protein from Mycobacterium leprae (316 aa)%2CFASTA scores: opt: 1762%2C E(): 0%2C (87.6%25 identity in 314 aa overlap). Similar to proteins in Streptomyces coelicolor e.g. SC10A7.04|AL078618.1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=blaR;locus_tag=Rv1845c;product=Possible sensor-transducer protein BlaR;protein_id=CCP44611.1;transl_table=11
AL123456.3	EMBL	gene	2096183	2096599	.	-	.	ID=gene-Rv1846c;Name=blaI;gbkey=Gene;gene=blaI;gene_biotype=protein_coding;locus_tag=Rv1846c
AL123456.3	EMBL	CDS	2096183	2096599	.	-	0	ID=cds-CCP44612.1;Parent=gene-Rv1846c;Dbxref=EnsemblGenomes-Gn:Rv1846c,EnsemblGenomes-Tr:CCP44612,GOA:P9WMJ5,InterPro:IPR005650,InterPro:IPR011991,PDB:2G9W,NCBI_GP:CCP44612.1;Name=CCP44612.1;Note=Rv1846c%2C (MTCY359.27)%2C len: 138 aa. BlaI%2Ctranscriptional repressor. Equivalent to MLCB1788.17|AL008609 hypothetical protein from Mycobacterium leprae (142 aa)%2C FASTA scores: opt: 736 E(): 0%2C (95.1%25 identity in 123 aa overlap). Also similar to BLAI_BACLI|P06555 penicillinase repressor (128 aa)%2C fasta scores: opt: 114%2C E(): 0.12%2C (23.7%25 identity in 131 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=blaI;locus_tag=Rv1846c;product=Transcriptional repressor BlaI;protein_id=CCP44612.1;transl_table=11
AL123456.3	EMBL	gene	2096877	2097299	.	+	.	ID=gene-Rv1847;Name=Rv1847;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1847
AL123456.3	EMBL	CDS	2096877	2097299	.	+	0	ID=cds-CCP44613.1;Parent=gene-Rv1847;Dbxref=EnsemblGenomes-Gn:Rv1847,EnsemblGenomes-Tr:CCP44613,GOA:P9WIM3,InterPro:IPR003736,InterPro:IPR006683,InterPro:IPR029069,PDB:3S4K,NCBI_GP:CCP44613.1;Name=CCP44613.1;Note=Rv1847%2C (MTCY359.26c)%2C len: 140 aa. Conserved protein%2C possible thioesterase%2C some similarity to YBDB proteins of Escherichia coli and H. influenzae e.g. P15050|YBDB_ECOLI hypothetical 15.0 KD protein in ENTA-CSTA intergenic region (137 aa)%2C FASTA scores: opt: 232%2C E(): 6.6e-10%2C (35.8%25 identity in 106 aa overlap)%3B C48956|G142208 thioesterase from Arthrobacter sp (151 aa)%2C FASTA score: opt: 254%2C E(): 1.7e-11%2C (33.3%25 identity in 138 aa overlap). Also similar to AF064959|AF064959_1 hypothetical protein from Coxiella burnetii (148 aa)%2C FASTA score: opt: 264%2CE(): 9.3e- 12%2C (36.8%25 identity in 117 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1847;product=Conserved protein;protein_id=CCP44613.1;transl_table=11
AL123456.3	EMBL	gene	2097348	2097650	.	+	.	ID=gene-Rv1848;Name=ureA;gbkey=Gene;gene=ureA;gene_biotype=protein_coding;locus_tag=Rv1848
AL123456.3	EMBL	CDS	2097348	2097650	.	+	0	ID=cds-CCP44614.1;Parent=gene-Rv1848;Dbxref=EnsemblGenomes-Gn:Rv1848,EnsemblGenomes-Tr:CCP44614,GOA:P9WFE7,InterPro:IPR002026,InterPro:IPR012010,PDB:2FVH,NCBI_GP:CCP44614.1;Name=CCP44614.1;Note=Rv1848%2C (MTCY359.25c)%2C len: 100 aa. UreA%2C urease gamma subunit. Similar to URE3_MYCTU|P50043 from Mycobacterium tuberculosis (100 aa)%2C FASTA scores: opt: 630%2C E(): 1.3e-36%2C (99.0%25 identity in 100 aa overlap). Belongs to the urease gamma subunit family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ureA;locus_tag=Rv1848;product=Urease gamma subunit UreA (urea amidohydrolase);protein_id=CCP44614.1;transl_table=11
AL123456.3	EMBL	gene	2097647	2097961	.	+	.	ID=gene-Rv1849;Name=ureB;gbkey=Gene;gene=ureB;gene_biotype=protein_coding;locus_tag=Rv1849
AL123456.3	EMBL	CDS	2097647	2097961	.	+	0	ID=cds-CCP44615.1;Parent=gene-Rv1849;Dbxref=EnsemblGenomes-Gn:Rv1849,EnsemblGenomes-Tr:CCP44615,GOA:P9WFE9,InterPro:IPR002019,NCBI_GP:CCP44615.1;Name=CCP44615.1;Note=Rv1849%2C (MTCY359.24c)%2C len: 104 aa. UreB%2C urease beta subunit. Identical to URE2_MYCTU|P50048 urease beta subunit from Mycobacterium tuberculosis (100 aa). Belongs to the urease gamma subunit family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ureB;locus_tag=Rv1849;product=Urease beta subunit UreB (urea amidohydrolase);protein_id=CCP44615.1;transl_table=11
AL123456.3	EMBL	gene	2097961	2099694	.	+	.	ID=gene-Rv1850;Name=ureC;gbkey=Gene;gene=ureC;gene_biotype=protein_coding;locus_tag=Rv1850
AL123456.3	EMBL	CDS	2097961	2099694	.	+	0	ID=cds-CCP44616.1;Parent=gene-Rv1850;Dbxref=EnsemblGenomes-Gn:Rv1850,EnsemblGenomes-Tr:CCP44616,GOA:P9WFF1,InterPro:IPR005848,InterPro:IPR006680,InterPro:IPR011059,InterPro:IPR011612,InterPro:IPR017950,InterPro:IPR017951,InterPro:IPR029754,NCBI_GP:CCP44616.1;Name=CCP44616.1;Note=Rv1850%2C (MTCY359.23c)%2C len: 577 aa. UreC%2C urease alpha subunit. Similar to URE1_MYCTU|P50042 from Mycobacterium tuberculosis (577 aa)%2C FASTA scores: opt: 3794%2C E(): 0%2C (98.3%25 identity in 577 aa overlap). Contains PS00145 Urease active site motif. Belongs to the urease family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ureC;inference=protein motif:PROSITE:PS00145;locus_tag=Rv1850;product=Urease alpha subunit UreC (urea amidohydrolase);protein_id=CCP44616.1;transl_table=11
AL123456.3	EMBL	gene	2099694	2100329	.	+	.	ID=gene-Rv1851;Name=ureF;gbkey=Gene;gene=ureF;gene_biotype=protein_coding;locus_tag=Rv1851
AL123456.3	EMBL	CDS	2099694	2100329	.	+	0	ID=cds-CCP44617.1;Parent=gene-Rv1851;Dbxref=EnsemblGenomes-Gn:Rv1851,EnsemblGenomes-Tr:CCP44617,GOA:P9WFE5,InterPro:IPR002639,NCBI_GP:CCP44617.1;Name=CCP44617.1;Note=Rv1851%2C (MTCY359.22c)%2C len: 211 aa. UreF%2C urease accessory protein. Identical to UREF_MYCTU|P50050 from M. tuberculosis.;gbkey=CDS;gene=ureF;locus_tag=Rv1851;product=Urease accessory protein UreF;protein_id=CCP44617.1;transl_table=11
AL123456.3	EMBL	gene	2100340	2101014	.	+	.	ID=gene-Rv1852;Name=ureG;gbkey=Gene;gene=ureG;gene_biotype=protein_coding;locus_tag=Rv1852
AL123456.3	EMBL	CDS	2100340	2101014	.	+	0	ID=cds-CCP44618.1;Parent=gene-Rv1852;Dbxref=EnsemblGenomes-Gn:Rv1852,EnsemblGenomes-Tr:CCP44618,GOA:P9WFE3,InterPro:IPR003495,InterPro:IPR004400,InterPro:IPR012202,InterPro:IPR027417,NCBI_GP:CCP44618.1;Name=CCP44618.1;Note=Rv1852%2C (MTCY359.21c)%2C len: 224 aa. UreG%2C urease accessory protein. Identical to UREG_MYCTU|P50051 from M. tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the UreG family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ureG;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1852;product=Urease accessory protein UreG;protein_id=CCP44618.1;transl_table=11
AL123456.3	EMBL	gene	2101022	2101648	.	+	.	ID=gene-Rv1853;Name=ureD;gbkey=Gene;gene=ureD;gene_biotype=protein_coding;locus_tag=Rv1853
AL123456.3	EMBL	CDS	2101022	2101648	.	+	0	ID=cds-CCP44619.1;Parent=gene-Rv1853;Dbxref=EnsemblGenomes-Gn:Rv1853,EnsemblGenomes-Tr:CCP44619,GOA:P95161,InterPro:IPR002669,UniProtKB/TrEMBL:P95161,NCBI_GP:CCP44619.1;Name=CCP44619.1;Note=Rv1853%2C (MTCY359.20c)%2C len: 208 aa. UreD%2C probable urease accessory protein. Similar to URED_YEREN|P42868 Urease operon ureD protein from Yersinia enterocolitica (325 aa)%2C Fasta scores: opt: 114%2C E(): 0.37%2C (25.2%25 identity in 119 aa overlap).;gbkey=CDS;gene=ureD;locus_tag=Rv1853;product=Probable urease accessory protein UreD;protein_id=CCP44619.1;transl_table=11
AL123456.3	EMBL	gene	2101651	2103042	.	-	.	ID=gene-Rv1854c;Name=ndh;gbkey=Gene;gene=ndh;gene_biotype=protein_coding;locus_tag=Rv1854c
AL123456.3	EMBL	CDS	2101651	2103042	.	-	0	ID=cds-CCP44620.1;Parent=gene-Rv1854c;Dbxref=EnsemblGenomes-Gn:Rv1854c,EnsemblGenomes-Tr:CCP44620,GOA:P95160,InterPro:IPR001327,InterPro:IPR013027,InterPro:IPR023753,UniProtKB/TrEMBL:P95160,NCBI_GP:CCP44620.1;Name=CCP44620.1;Note=Rv1854c%2C (MTCY359.19)%2C len: 463 aa. Probable ndh%2CNADH dehydrogenase (see citations below)%2C similar to several e.g. S74826 NADH dehydrogenase from Synechocystis sp. (445 aa)%2C FASTA score: opt: 1228%2C E(): 0%2C (46.3%25 identity in 432 aa overlap). Highly similar to Rv0392c|Z84725|g1817703 from Mycobacterium tuberculosis (470 aa)%2C FASTA scores: opt: 1911%2C E(): 0%2C (64.7%25 identity in 459 aa overlap)%3B and Rv1812c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ndh;locus_tag=Rv1854c;product=Probable NADH dehydrogenase Ndh;protein_id=CCP44620.1;transl_table=11
AL123456.3	EMBL	gene	2103184	2104107	.	-	.	ID=gene-Rv1855c;Name=Rv1855c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1855c
AL123456.3	EMBL	CDS	2103184	2104107	.	-	0	ID=cds-CCP44621.1;Parent=gene-Rv1855c;Dbxref=EnsemblGenomes-Gn:Rv1855c,EnsemblGenomes-Tr:CCP44621,GOA:P95159,InterPro:IPR011251,InterPro:IPR019952,UniProtKB/TrEMBL:P95159,NCBI_GP:CCP44621.1;Name=CCP44621.1;Note=Rv1855c%2C (MTCY359.18)%2C len: 307 aa. Possible oxidoreductase%2C possibly a monooxygenase. Contains PS00217 Sugar transport proteins signature 2%2C probably fortuitously. Similar to G487716 (78-11) lincomycin production genes (29.2%25 identity in 154 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv0953c%2C Rv0791c%2C Rv0132c%2C Rv2951c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00217;locus_tag=Rv1855c;product=Possible oxidoreductase;protein_id=CCP44621.1;transl_table=11
AL123456.3	EMBL	gene	2104146	2104823	.	-	.	ID=gene-Rv1856c;Name=Rv1856c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1856c
AL123456.3	EMBL	CDS	2104146	2104823	.	-	0	ID=cds-CCP44622.1;Parent=gene-Rv1856c;Dbxref=EnsemblGenomes-Gn:Rv1856c,EnsemblGenomes-Tr:CCP44622,GOA:P9WGQ1,InterPro:IPR016040,NCBI_GP:CCP44622.1;Name=CCP44622.1;Note=Rv1856c%2C (MTCY359.17)%2C len: 225 aa. Possible oxidoreductase. Equivalent to MLCB1788.11c|AL008609 oxidoreductase from Mycobacterium leprae (224 aa)%2C FASTA scores: opt: 1211%2C E(): 0%3B (80.4%25 identity in 224 aa overlap). Some similarity to dehydrogenases of short-chain dehydrogenase/reductase family and fatty-acyl CoA reductases e.g. P16543|DHK2_STRVN granaticin polyketide synthase P (249 aa)%2C FASTA score: opt: 194%2C E(): 1.1e-05%2C(32.5%25 identity in 237 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1856c;product=Possible oxidoreductase;protein_id=CCP44622.1;transl_table=11
AL123456.3	EMBL	gene	2104985	2105770	.	+	.	ID=gene-Rv1857;Name=modA;gbkey=Gene;gene=modA;gene_biotype=protein_coding;locus_tag=Rv1857
AL123456.3	EMBL	CDS	2104985	2105770	.	+	0	ID=cds-CCP44623.1;Parent=gene-Rv1857;Dbxref=EnsemblGenomes-Gn:Rv1857,EnsemblGenomes-Tr:CCP44623,GOA:P9WGU3,InterPro:IPR005950,InterPro:IPR006059,NCBI_GP:CCP44623.1;Name=CCP44623.1;Note=Rv1857%2C (MTCY359.16c)%2C len: 261 aa. Probable modA%2Cmolybdate-binding protein attached to membrane by lipid-modified N-terminal cysteine (contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site)%2Ccomponent of molybdate transport system (see citations below). Shows strong similarity to precursors of periplasmic molybdate/sulphate binding proteins e.g. O31229|Y10817|ANY108174 ModA from Arthrobacter nicotinovorans (260 aa)%2C FASTA score: opt: 725%2C E(): 0%2C(47.8%25 identity in 249 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=modA;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1857;product=Probable molybdate-binding lipoprotein ModA;protein_id=CCP44623.1;transl_table=11
AL123456.3	EMBL	gene	2105773	2106567	.	+	.	ID=gene-Rv1858;Name=modB;gbkey=Gene;gene=modB;gene_biotype=protein_coding;locus_tag=Rv1858
AL123456.3	EMBL	CDS	2105773	2106567	.	+	0	ID=cds-CCP44624.1;Parent=gene-Rv1858;Dbxref=EnsemblGenomes-Gn:Rv1858,EnsemblGenomes-Tr:CCP44624,GOA:P9WG13,InterPro:IPR000515,InterPro:IPR006469,InterPro:IPR011867,NCBI_GP:CCP44624.1;Name=CCP44624.1;Note=Rv1858%2C (MTCY359.15c)%2C len: 264 aa. Probable modB%2Cmolybdenum-transport integral membrane protein ABC transporter (see citation below)%2C similar to others e.g. Y10817|ANY108175 ModB from Arthrobacter (239 aa)%2C FASTA scores: opt: 937%2C E(): 0%2C (67.8%25 identity in 230 aa overlap)%3B etc. Similar to other Mycobacterium tuberculosis transport proteins e.g. Rv2039c%2C Rv2316%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=modB;locus_tag=Rv1858;product=Probable molybdenum-transport integral membrane protein ABC transporter ModB;protein_id=CCP44624.1;transl_table=11
AL123456.3	EMBL	gene	2106574	2107683	.	+	.	ID=gene-Rv1859;Name=modC;gbkey=Gene;gene=modC;gene_biotype=protein_coding;locus_tag=Rv1859
AL123456.3	EMBL	CDS	2106574	2107683	.	+	0	ID=cds-CCP44625.1;Parent=gene-Rv1859;Dbxref=EnsemblGenomes-Gn:Rv1859,EnsemblGenomes-Tr:CCP44625,GOA:P9WQL3,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR005116,InterPro:IPR008995,InterPro:IPR015852,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP44625.1;Name=CCP44625.1;Note=Rv1859%2C (MTCY359.14c)%2C len: 369 aa. Probable modC%2Cmolybdenum-transport ATP-binding protein ABC transporter (see citation below)%2C similar to others e.g. Y10817|ANY108176 ModC from Arthrobacter (349 aa)%2C FASTA scores: opt: 895%2C E(): 0%2C (46.0%25 identity in 361 aa overlap)%3B etc. Shows similarity to other Mycobacterium tuberculosis ABC-transporter proteins e.g. Rv0073%2C Rv1238%2CRv2564%2C etc. Contains both PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signatures involved in molybdate uptake. Belongs to the ATP-binding transport protein family (ABC transporters).;gbkey=CDS;gene=modC;inference=protein motif:PROSITE:PS00211;locus_tag=Rv1859;product=Probable molybdenum-transport ATP-binding protein ABC transporter ModC;protein_id=CCP44625.1;transl_table=11
AL123456.3	EMBL	gene	2107736	2108713	.	+	.	ID=gene-Rv1860;Name=apa;gbkey=Gene;gene=apa;gene_biotype=protein_coding;gene_synonym=modD,mpt32;locus_tag=Rv1860
AL123456.3	EMBL	CDS	2107736	2108713	.	+	0	ID=cds-CCP44626.1;Parent=gene-Rv1860;Dbxref=EnsemblGenomes-Gn:Rv1860,EnsemblGenomes-Tr:CCP44626,GOA:P9WIR7,InterPro:IPR010801,NCBI_GP:CCP44626.1;Name=CCP44626.1;Note=Rv1860%2C (MT1908%2C MTCY359.0013)%2C len: 325 aa. Apa (alternate gene names: mpt32%2C modD)%2C Ala-%2C Pro-rich 45/47 kDa secreted protein%2C very similar to P46842|N43L_MYCLE from Mycobacterium leprae (287 aa)%2C FASTA scores: opt: 1166%2C E(): 0%2C (66.4%25 identity in 298 aa overlap). Known to be glycosylated fibronectin-binding protein (see some citations). Changes in the mannosylation pattern of this protein affect its ability to stimulate T-lymphocyte response. Major immunodominant antigen that has potential as a vaccine against tuberculosis. APA-ELISA could be used in diagnosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=apa;locus_tag=Rv1860;product=Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen);protein_id=CCP44626.1;transl_table=11
AL123456.3	EMBL	gene	2109165	2109470	.	+	.	ID=gene-Rv1861;Name=Rv1861;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1861
AL123456.3	EMBL	CDS	2109165	2109470	.	+	0	ID=cds-CCP44627.1;Parent=gene-Rv1861;Dbxref=EnsemblGenomes-Gn:Rv1861,EnsemblGenomes-Tr:CCP44627,GOA:P95154,InterPro:IPR007341,UniProtKB/TrEMBL:P95154,NCBI_GP:CCP44627.1;Name=CCP44627.1;Note=Rv1861%2C (MTCY359.12c)%2C len: 101 aa. Probable conserved transmembrane protein%2C showing weak similarity to AE002069|AE002069_10 hypothetical protein from Deinococcus radiodurans (146 aa)%2C FASTA scores: opt: 154%2C E(): 0.0027%2C(30.8%25 identity in 104 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv1861;product=Probable conserved transmembrane protein;protein_id=CCP44627.1;transl_table=11
AL123456.3	EMBL	gene	2109544	2110584	.	+	.	ID=gene-Rv1862;Name=adhA;gbkey=Gene;gene=adhA;gene_biotype=protein_coding;locus_tag=Rv1862
AL123456.3	EMBL	CDS	2109544	2110584	.	+	0	ID=cds-CCP44628.1;Parent=gene-Rv1862;Dbxref=EnsemblGenomes-Gn:Rv1862,EnsemblGenomes-Tr:CCP44628,GOA:P9WQC1,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR014187,InterPro:IPR016040,NCBI_GP:CCP44628.1;Name=CCP44628.1;Note=Rv1862%2C (MTCY359.11)%2C len: 346 aa. Probable adhA%2Calcohol dehydrogenase%2C similar to ADH2_BACST|P42327 alcohol dehydrogenase (339 aa)%2C FASTA scores: opt: 630%2C E(): 2.4e-32 (34.4%25 identity in 320 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adhA;inference=protein motif:PROSITE:PS00059;locus_tag=Rv1862;product=Probable alcohol dehydrogenase AdhA;protein_id=CCP44628.1;transl_table=11
AL123456.3	EMBL	gene	2110591	2111361	.	-	.	ID=gene-Rv1863c;Name=Rv1863c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1863c
AL123456.3	EMBL	CDS	2110591	2111361	.	-	0	ID=cds-CCP44629.1;Parent=gene-Rv1863c;Dbxref=EnsemblGenomes-Gn:Rv1863c,EnsemblGenomes-Tr:CCP44629,GOA:P95152,InterPro:IPR003675,InterPro:IPR015837,UniProtKB/TrEMBL:P95152,NCBI_GP:CCP44629.1;Name=CCP44629.1;Note=Rv1863c%2C (MTCY359.10)%2C len: 256 aa. Probable conserved integral membrane protein%2C similar to Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from Mycobacterium tuberculosis (209 aa)%2C FASTA scores: opt: 199%2C E(): 1e-06%2C (33.2%25 identity in 220 aa overlap)%3B and Rv0658c.;gbkey=CDS;locus_tag=Rv1863c;product=Probable conserved integral membrane protein;protein_id=CCP44629.1;transl_table=11
AL123456.3	EMBL	gene	2111354	2112109	.	-	.	ID=gene-Rv1864c;Name=Rv1864c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1864c
AL123456.3	EMBL	CDS	2111354	2112109	.	-	0	ID=cds-CCP44630.1;Parent=gene-Rv1864c;Dbxref=EnsemblGenomes-Gn:Rv1864c,EnsemblGenomes-Tr:CCP44630,GOA:P95151,InterPro:IPR005163,InterPro:IPR005302,InterPro:IPR011037,InterPro:IPR015808,UniProtKB/TrEMBL:P95151,NCBI_GP:CCP44630.1;Name=CCP44630.1;Note=Rv1864c%2C (MTCY359.09)%2C len: 251 aa. Conserved protein. Similar to other hypothetical proteins e.g. AL031317|SC6G4.43 from Streptomyces coelicolor cosmid 6G (233 aa)%2C FASTA scores: opt: 716%2C E(): 0%2C (54.4%25 identity in 215 aa overlap)%3B also P43976|YIIM_HAEIN hypothetical protein hi0278 (221 aa)%2C FASTA scores: opt: 223%2C E(): 3.8e-08%2C (29.5%25 identity in 173 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1864c;product=Conserved protein;protein_id=CCP44630.1;transl_table=11
AL123456.3	EMBL	gene	2112106	2112966	.	-	.	ID=gene-Rv1865c;Name=Rv1865c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1865c
AL123456.3	EMBL	CDS	2112106	2112966	.	-	0	ID=cds-CCP44631.1;Parent=gene-Rv1865c;Dbxref=EnsemblGenomes-Gn:Rv1865c,EnsemblGenomes-Tr:CCP44631,GOA:P95150,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:P95150,NCBI_GP:CCP44631.1;Name=CCP44631.1;Note=Rv1865c%2C (MTCY359.08)%2C len: 286 aa. Probable short-chain dehydrogenase%2C highly similar to C-terminus of NP_301650.1|NC_00267 putative oxidoreductase from Mycobacterium leprae (596 aa). Also similar to various dehydrogenases%2C generally belonging to short-chain family%2Ce.g. AAG02168.1|AF212041_24|AF212041 3-oxoacyl-(acylcarrier protein) reductase from Zymomonas mobilis (251 aa)%3B P50198|LINX_PSEPA 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-DIOL dehydrogenase from Sphingomonas paucimobilis (250 aa)%3B NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar to acetoin reductase) from Mesorhizobium loti (256 aa)%3B etc. And highly similar to C-terminus of ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis (592 aa)%3B and many other oxidoreductases from Mycobacterium tuberculosis e.g. Y00P_MYCTU|Q10402 putative oxidoreductase (650 aa)%2C FASTA scores: opt: 439%2C E(): 8.9e-20%2C (32.5%25 identity in 280 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1865c;product=Probable short-chain type dehydrogenase;protein_id=CCP44631.1;transl_table=11
AL123456.3	EMBL	gene	2113140	2115476	.	+	.	ID=gene-Rv1866;Name=Rv1866;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1866
AL123456.3	EMBL	CDS	2113140	2115476	.	+	0	ID=cds-CCP44632.1;Parent=gene-Rv1866;Dbxref=EnsemblGenomes-Gn:Rv1866,EnsemblGenomes-Tr:CCP44632,GOA:P95149,InterPro:IPR003673,InterPro:IPR023606,UniProtKB/TrEMBL:P95149,NCBI_GP:CCP44632.1;Name=CCP44632.1;Note=Rv1866%2C (MTCY359.07c)%2C len: 778 aa. Conserved protein%2C N-terminal region similar to fatty acyl-CoA racemases e.g. Rv0855%2C Rv1143%2C and C-terminal region (from aa 370) similar to L-carnitine dehydratases%2C racemases%2C and Rv3272|MTCY71.12 Mycobacterium tuberculosis (394 aa)%2C FASTA score: opt: 472%2C E(): 2.1e-21%2C (29.9%25 identity in 388 aa overlap). Also similar to P31572|CAIB_ECOLI L-carnitine dehydratase (405 aa)%2C FASTA score: opt: 306%2C E(): 2.1e-11%2C(23.3%25 identity in 424 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1866;product=Conserved protein;protein_id=CCP44632.1;transl_table=11
AL123456.3	EMBL	gene	2115764	2117248	.	+	.	ID=gene-Rv1867;Name=Rv1867;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1867
AL123456.3	EMBL	CDS	2115764	2117248	.	+	0	ID=cds-CCP44633.1;Parent=gene-Rv1867;Dbxref=EnsemblGenomes-Gn:Rv1867,EnsemblGenomes-Tr:CCP44633,GOA:P95148,InterPro:IPR016038,InterPro:IPR016039,UniProtKB/TrEMBL:P95148,NCBI_GP:CCP44633.1;Name=CCP44633.1;Note=Rv1867%2C (MTCY359.06c)%2C len: 494 aa. Conserved protein%2C some similarity to acetyl CoA synthase and to lipid carriers. FASTA best: E155295 acetyl CoA synthase (388 aa)%2C opt: 213%2C E(): 4.5e-07%2C (23.2%25 identity in 423 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1867;product=Conserved protein;protein_id=CCP44633.1;transl_table=11
AL123456.3	EMBL	gene	2117347	2119446	.	+	.	ID=gene-Rv1868;Name=Rv1868;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1868
AL123456.3	EMBL	CDS	2117347	2119446	.	+	0	ID=cds-CCP44634.1;Parent=gene-Rv1868;Dbxref=EnsemblGenomes-Gn:Rv1868,EnsemblGenomes-Tr:CCP44634,GOA:P95147,InterPro:IPR016040,UniProtKB/TrEMBL:P95147,NCBI_GP:CCP44634.1;Name=CCP44634.1;Note=Rv1868%2C (MTCY359.05c)%2C len: 699 aa. Conserved hypothetical protein%2C similar to products of three consecutive ORFS in Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa)%2C FASTA scores: opt: 314%2CE(): 9.9e-12%2C (35.2%25 identity in 213 aa overlap)%3B MLCB2052.17%2C and MLCB2052.16. Also similar to M. tuberculosis hypothetical protein Rv2047c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1868;product=Conserved hypothetical protein;protein_id=CCP44634.1;transl_table=11
AL123456.3	EMBL	gene	2119460	2120695	.	-	.	ID=gene-Rv1869c;Name=Rv1869c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1869c
AL123456.3	EMBL	CDS	2119460	2120695	.	-	0	ID=cds-CCP44635.1;Parent=gene-Rv1869c;Dbxref=EnsemblGenomes-Gn:Rv1869c,EnsemblGenomes-Tr:CCP44635,GOA:P95146,InterPro:IPR001327,InterPro:IPR004099,InterPro:IPR013027,InterPro:IPR016156,InterPro:IPR023753,InterPro:IPR028202,UniProtKB/TrEMBL:P95146,NCBI_GP:CCP44635.1;Name=CCP44635.1;Note=Rv1869c%2C (MTCY359.04)%2C len: 411 aa. Probable reductase (1.-.-.-). Similar to several reductases e.g. CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa)%3B THCD_RHOSO|P43494 rhodocoxin reductase (426 aa)%2C FASTA scores: opt: 904%2C E(): 0%2C (40.8%25 identity in 370 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv0688 (406 aa) (39.9%25 identity in 391 aa overlap)%3B and Rv0253 (nitrite reductase subunit).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1869c;product=Probable reductase;protein_id=CCP44635.1;transl_table=11
AL123456.3	EMBL	gene	2120795	2121430	.	-	.	ID=gene-Rv1870c;Name=Rv1870c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1870c
AL123456.3	EMBL	CDS	2120795	2121430	.	-	0	ID=cds-CCP44636.1;Parent=gene-Rv1870c;Dbxref=EnsemblGenomes-Gn:Rv1870c,EnsemblGenomes-Tr:CCP44636,GOA:P95145,InterPro:IPR011257,UniProtKB/TrEMBL:P95145,NCBI_GP:CCP44636.1;Name=CCP44636.1;Note=Rv1870c%2C (MTCY359.03)%2C len: 211 aa. Conserved hypothetical protein. Some similarity to SC6F7.17c hypothetical protein from Streptomyces coelicolor (216 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1870c;product=Conserved hypothetical protein;protein_id=CCP44636.1;transl_table=11
AL123456.3	EMBL	gene	2121495	2121884	.	-	.	ID=gene-Rv1871c;Name=Rv1871c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1871c
AL123456.3	EMBL	CDS	2121495	2121884	.	-	0	ID=cds-CCP44637.1;Parent=gene-Rv1871c;Dbxref=EnsemblGenomes-Gn:Rv1871c,EnsemblGenomes-Tr:CCP44637,GOA:P95144,InterPro:IPR004378,InterPro:IPR012349,UniProtKB/TrEMBL:P95144,NCBI_GP:CCP44637.1;Name=CCP44637.1;Note=Rv1871c%2C (MTCY359.02)%2C len: 129 aa. Conserved protein%2C similar to Mycobacterium tuberculosis hypothetical proteins Q11057|Rv1261|MTCY50.21 (149 aa)%2C FASTA score: opt: 125%2C E(): 0.019%2C (32.6%25 identity in 89 aa overlap)%3B Rv0523c%2C and Rv1598c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1871c;product=Conserved protein;protein_id=CCP44637.1;transl_table=11
AL123456.3	EMBL	gene	2121907	2123151	.	-	.	ID=gene-Rv1872c;Name=lldD2;gbkey=Gene;gene=lldD2;gene_biotype=protein_coding;locus_tag=Rv1872c
AL123456.3	EMBL	CDS	2121907	2123151	.	-	0	ID=cds-CCP44638.1;Parent=gene-Rv1872c;Dbxref=EnsemblGenomes-Gn:Rv1872c,EnsemblGenomes-Tr:CCP44638,GOA:P9WND5,InterPro:IPR000262,InterPro:IPR008259,InterPro:IPR012133,InterPro:IPR013785,NCBI_GP:CCP44638.1;Name=CCP44638.1;Note=Rv1872c%2C (MTCY180.46%2C MTCY359.01)%2C len: 414 aa (start uncertain). Possible lldD2%2C L-lactate dehydrogenase (cytochrome)%2C similar to other lactate dehydrogenases and other oxidases e.g. LLDD_ECOLI|P33232 l-lactate dehydrogenase (cytochrome) from Escherichia coli strain K12 (396 aa)%2C FASTA results: opt: 674%2C E(): 1.1e-37%2C (40.5%25 identity in 279 aa overlap)%3B Q51135 lactate dehydrogenase from Neisseria meningitidis (390 aa)%2C FASTA results: opt: 309%2C E(): 4.1e-15%2C (42.5%25 identity in 113 aa overlap)%3B etc. Also shows similarity with Rv0694|lldD1|MTCY210.11 possible L-lactate dehydrogenase (cytochrome) from Mycobacterium tuberculosis (396 aa). Contains PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenases family. Phosphorylated in vitro by PknJ|Rv2088 (See Arora et al.%2C2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lldD2;inference=protein motif:PROSITE:PS00557;locus_tag=Rv1872c;product=Possible L-lactate dehydrogenase (cytochrome) LldD2;protein_id=CCP44638.1;transl_table=11
AL123456.3	EMBL	gene	2123174	2123611	.	+	.	ID=gene-Rv1873;Name=Rv1873;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1873
AL123456.3	EMBL	CDS	2123174	2123611	.	+	0	ID=cds-CCP44639.1;Parent=gene-Rv1873;Dbxref=EnsemblGenomes-Gn:Rv1873,EnsemblGenomes-Tr:CCP44639,InterPro:IPR014937,PDB:2JEK,UniProtKB/TrEMBL:O07756,NCBI_GP:CCP44639.1;Name=CCP44639.1;Note=Rv1873%2C (MTCY180.45c)%2C len: 145 aa. Conserved hypothetical protein. Some similarity to AL591783 hypothetical protein from Sinorhizobium meliloti.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1873;product=Conserved hypothetical protein;protein_id=CCP44639.1;transl_table=11
AL123456.3	EMBL	gene	2123684	2124370	.	+	.	ID=gene-Rv1874;Name=Rv1874;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1874
AL123456.3	EMBL	CDS	2123684	2124370	.	+	0	ID=cds-CCP44640.1;Parent=gene-Rv1874;Dbxref=EnsemblGenomes-Gn:Rv1874,EnsemblGenomes-Tr:CCP44640,GOA:O07755,InterPro:IPR009799,InterPro:IPR011008,UniProtKB/TrEMBL:O07755,NCBI_GP:CCP44640.1;Name=CCP44640.1;Note=Rv1874%2C (MTCY180.44c)%2C len: 228 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1874;product=Unknown protein;protein_id=CCP44640.1;transl_table=11
AL123456.3	EMBL	gene	2124381	2124824	.	+	.	ID=gene-Rv1875;Name=Rv1875;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1875
AL123456.3	EMBL	CDS	2124381	2124824	.	+	0	ID=cds-CCP44641.1;Parent=gene-Rv1875;Dbxref=EnsemblGenomes-Gn:Rv1875,EnsemblGenomes-Tr:CCP44641,GOA:O07754,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019920,UniProtKB/TrEMBL:O07754,NCBI_GP:CCP44641.1;Name=CCP44641.1;Note=Rv1875%2C (MTCY180.43c)%2C len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa)%2C FASTA scores: opt: 178%2C E(): 7.4e-06%2C (26.9%25 identity in 130 aa overlap)%3B Rv0121c and Rv2074. Also similar to AL079356|SC6G9.21 hypothetical protein from Streptomyces coelicolor (144 aa)%2C FASTA scores: opt: 239%2C E(): 3.1 e-09%2C(38.7%25 identity in 137 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1875;product=Conserved protein;protein_id=CCP44641.1;transl_table=11
AL123456.3	EMBL	gene	2125340	2125819	.	+	.	ID=gene-Rv1876;Name=bfrA;gbkey=Gene;gene=bfrA;gene_biotype=protein_coding;gene_synonym=bfr;locus_tag=Rv1876
AL123456.3	EMBL	CDS	2125340	2125819	.	+	0	ID=cds-CCP44642.1;Parent=gene-Rv1876;Dbxref=EnsemblGenomes-Gn:Rv1876,EnsemblGenomes-Tr:CCP44642,GOA:P9WPQ9,InterPro:IPR002024,InterPro:IPR008331,InterPro:IPR009040,InterPro:IPR009078,InterPro:IPR012347,PDB:2WTL,PDB:3QB9,PDB:3UOF,PDB:3UOI,NCBI_GP:CCP44642.1;Name=CCP44642.1;Note=Rv1876%2C (MTCY180.42c)%2C len: 159 aa. Probable bfrA (alternate gene name: bfr)%2C bacterioferritin (see citation below)%2C similar to BFR_MYCLE|P43315 bacterioferritin (bfr) from Mycobacterium leprae (159 aa)%2C FASTA results: opt: 958%2C E(): 0%2C (90.6%25 identity in 159 aa overlap). Also similar to Rv3841|MTCY01A6.28c|bfrB possible bacterioferritin from Mycobacterium tuberculosis (181 aa). Belongs to the bacterioferritin family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bfrA;locus_tag=Rv1876;product=Probable bacterioferritin BfrA;protein_id=CCP44642.1;transl_table=11
AL123456.3	EMBL	gene	2125904	2127967	.	+	.	ID=gene-Rv1877;Name=Rv1877;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1877
AL123456.3	EMBL	CDS	2125904	2127967	.	+	0	ID=cds-CCP44643.1;Parent=gene-Rv1877;Dbxref=EnsemblGenomes-Gn:Rv1877,EnsemblGenomes-Tr:CCP44643,GOA:P9WG85,InterPro:IPR001958,InterPro:IPR005829,InterPro:IPR011701,InterPro:IPR011991,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP44643.1;Name=CCP44643.1;Note=Rv1877%2C (MTCY180.41c)%2C len: 687 aa. Probable conserved integral membrane protein%2C part of major facilitator superfamily (MFS)%2C similar to many antibiotic and drug efflux proteins. Similar to e.g. Q56175 TU22 dTDP-glucose dehydrtatase from Streptomyces violaceoruber (557 aa)%2C FASTA scores: opt: 895%2C E(): 0%2C (34.7%25 identity in 528 aa overlap). Also similar to Mycobacterium tuberculosis relatives protein%2C include Rv3728%2C Rv3239c%2CRv2846c%2C etc. Contains PS00217 Sugar transport proteins signature 2 (PS00217).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00217;locus_tag=Rv1877;product=Probable conserved integral membrane protein;protein_id=CCP44643.1;transl_table=11
AL123456.3	EMBL	gene	2128022	2129374	.	+	.	ID=gene-Rv1878;Name=glnA3;gbkey=Gene;gene=glnA3;gene_biotype=protein_coding;locus_tag=Rv1878
AL123456.3	EMBL	CDS	2128022	2129374	.	+	0	ID=cds-CCP44644.1;Parent=gene-Rv1878;Dbxref=EnsemblGenomes-Gn:Rv1878,EnsemblGenomes-Tr:CCP44644,GOA:O07752,InterPro:IPR008146,InterPro:IPR014746,UniProtKB/TrEMBL:O07752,NCBI_GP:CCP44644.1;Name=CCP44644.1;Note=Rv1878%2C (MTCY180.40c)%2C len: 450 aa. Probable glnA3%2Cglutamine synthetase class I%2C similar to many e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa)%2C FASTA results: opt: 497%2C E(): 5.2e-23%2C (29.0%25 identity in 331 aa overlap)%3B etc. Also similar to C-terminus of FLUG_EMENI|P38094 flug protein from emericella nidulans (865 aa)%2C FASTA scores: opt: 227%2C E (): 6.4e-13%2C (29.9%25 identity in 394 aa overlap). Note that the downstream ORF MTCY180.39c is similar to the N-terminus. Also similar to three other potential glutamine synthases in M. tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427 .03c%3B Rv2860c|MTV003.06c|glnA4 and Rv2220|glnA1. Belongs to the glutamine synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnA3;locus_tag=Rv1878;product=Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I);protein_id=CCP44644.1;transl_table=11
AL123456.3	EMBL	gene	2129377	2130513	.	+	.	ID=gene-Rv1879;Name=Rv1879;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1879
AL123456.3	EMBL	CDS	2129377	2130513	.	+	0	ID=cds-CCP44645.1;Parent=gene-Rv1879;Dbxref=EnsemblGenomes-Gn:Rv1879,EnsemblGenomes-Tr:CCP44645,GOA:O07751,InterPro:IPR006992,UniProtKB/TrEMBL:O07751,NCBI_GP:CCP44645.1;Name=CCP44645.1;Note=Rv1879%2C (MTCY180.39c)%2C len: 378 aa. Conserved hypothetical protein%2C similar to SCC22.14c|AL096839 hypothetical protein from Streptomyces coelicolor (368 aa)%2CFASTA results: opt: 772%2C E(): 0 (40.3%25 identity in 372 aa overlap)%3B and to N-terminal half of nodulin/glutamate-ammonia ligase-like protein. Some similarity to N-terminus of AL132958|ATT4D2_11 Arabidopsis thaliana (845 aa)%2C FASTA results: opt: 354%2C E(): 3.1e-16%2C(29.2%25 identity in 383 aa overlap)%3B and to P38094|FLUG_EMENI Flug protein of Emericella nidulans (865 aa)%2C FASTA results: opt: 306%2C E(): 6.2e-13%2C (26.5%25 identity in 415 aa overlap). Note that the upstream ORF Rv1878|MTCY18 0.40c is similar to the C-terminus.;gbkey=CDS;locus_tag=Rv1879;product=Conserved hypothetical protein;protein_id=CCP44645.1;transl_table=11
AL123456.3	EMBL	gene	2130541	2131857	.	-	.	ID=gene-Rv1880c;Name=cyp140;gbkey=Gene;gene=cyp140;gene_biotype=protein_coding;locus_tag=Rv1880c
AL123456.3	EMBL	CDS	2130541	2131857	.	-	0	ID=cds-CCP44646.1;Parent=gene-Rv1880c;Dbxref=EnsemblGenomes-Gn:Rv1880c,EnsemblGenomes-Tr:CCP44646,GOA:P9WPL9,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,NCBI_GP:CCP44646.1;Name=CCP44646.1;Note=Rv1880c%2C (MT1929%2C MTCY180.38)%2C len: 438 aa. Probable cyp140%2C cytochrome p450. Similar to Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase (404 aa)%2C FASTA scores: opt: 775%2C E(): 0%2C (44.2%25 identity in 319 aa overlap)%3B and other members of the cytochrome P450 family. Related to Mycobacterium tuberculosis proteins include: Rv0766c%2C Rv2266%2C Rv0778%2C etc. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp140;inference=protein motif:PROSITE:PS00086;locus_tag=Rv1880c;product=Probable cytochrome P450 140 Cyp140;protein_id=CCP44646.1;transl_table=11
AL123456.3	EMBL	gene	2131907	2132329	.	-	.	ID=gene-Rv1881c;Name=lppE;gbkey=Gene;gene=lppE;gene_biotype=protein_coding;locus_tag=Rv1881c
AL123456.3	EMBL	CDS	2131907	2132329	.	-	0	ID=cds-CCP44647.1;Parent=gene-Rv1881c;Dbxref=EnsemblGenomes-Gn:Rv1881c,EnsemblGenomes-Tr:CCP44647,GOA:O07750,UniProtKB/TrEMBL:O07750,NCBI_GP:CCP44647.1;Name=CCP44647.1;Note=Rv1881c%2C (MTCY180.37)%2C len: 140 aa. Possible lppE%2Clipoprotein%2C showing some similarity to L12238|MSG18S19K_1 19K antigen from Mycobacterium intracellulare (162 aa)%2CFASTA scores: opt: 137%2C E(): 0.0069%2C (27.6%25 identity in 156 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppE;locus_tag=Rv1881c;product=Possible conserved lipoprotein LppE;protein_id=CCP44647.1;transl_table=11
AL123456.3	EMBL	gene	2132370	2133203	.	-	.	ID=gene-Rv1882c;Name=Rv1882c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1882c
AL123456.3	EMBL	CDS	2132370	2133203	.	-	0	ID=cds-CCP44648.1;Parent=gene-Rv1882c;Dbxref=EnsemblGenomes-Gn:Rv1882c,EnsemblGenomes-Tr:CCP44648,GOA:O07749,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:O07749,NCBI_GP:CCP44648.1;Name=CCP44648.1;Note=Rv1882c%2C (MTCY180.36)%2C len: 277 aa. Probable short-chain dehydrogenase/reductase%2C similar to various dehydrogenases/reductases%2C generally belonging to SDR family%2C e.g. NP_250789.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (251 aa)%3B NP_421760.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (270 aa)%3B NP_107167.1|NC_002678 oxidoreductase (short chain dehydrogenase/reductase family) from Mesorhizobium loti (253 aa)%3B P50197|LINC_PSEPA 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-diol dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa)%2C FASTA scores: opt: 301%2C E(): 2.3e-12%2C (30.0%25 identity in 223 aa overlap)%3B etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Rv3057c%2C Rv1245%2C etc. Contains possible helix-turn-helix motif at aa 246-267 (+4.32 SD). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1882c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP44648.1;transl_table=11
AL123456.3	EMBL	gene	2133231	2133692	.	-	.	ID=gene-Rv1883c;Name=Rv1883c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1883c
AL123456.3	EMBL	CDS	2133231	2133692	.	-	0	ID=cds-CCP44649.1;Parent=gene-Rv1883c;Dbxref=EnsemblGenomes-Gn:Rv1883c,EnsemblGenomes-Tr:CCP44649,InterPro:IPR005031,InterPro:IPR023393,UniProtKB/TrEMBL:O07748,NCBI_GP:CCP44649.1;Name=CCP44649.1;Note=Rv1883c%2C (MTCY180.35)%2C len: 153 aa. Conserved hypothetical protein%2C some similarity to hypothetical proteins e.g. Rv2778c|AL008967|MTV002.43 from Mycobacterium tuberculosis (156 aa)%2C FASTA score: opt: 212%2C E(): 3.1e-08%2C(34.4%25 identity in 151 aa overlap). Also similar to U75434|SAU75434_3 Nsh-OrfB from Streptomyces actuosus (173 aa)%2C FASTA score: opt: 207%2C E(): 1.8e-07%2C (40.2%25 identity in 102 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1883c;product=Conserved hypothetical protein;protein_id=CCP44649.1;transl_table=11
AL123456.3	EMBL	gene	2133731	2134261	.	-	.	ID=gene-Rv1884c;Name=rpfC;gbkey=Gene;gene=rpfC;gene_biotype=protein_coding;locus_tag=Rv1884c
AL123456.3	EMBL	CDS	2133731	2134261	.	-	0	ID=cds-CCP44650.1;Parent=gene-Rv1884c;Dbxref=EnsemblGenomes-Gn:Rv1884c,EnsemblGenomes-Tr:CCP44650,GOA:O07747,InterPro:IPR010618,InterPro:IPR023346,PDB:4OW1,NCBI_GP:CCP44650.1;Name=CCP44650.1;Note=Rv1884c%2C (MTCY180.34)%2C len: 176 aa. Probable rpfC%2Cresuscitation promoting factor (see citation below)%2Csimilar to Z96935|MLRPF_1 resusicitation-promoting factor from Micrococcus luteus (220 aa)%2C FASTA score: opt: 287%2CE() : 3.3e-11%2C (40.0%25 identity in 120 aa overlap). Also similar to others from Mycobacterium tuberculosis: Rv2389c|MTCY253.32|RPFD probable resuscitation-promoting factor (154 aa)%2C FASTA score: opt: 382%2C E(): 7.1e-17%2C(55.4%25 identity in 101 aa overlap)%3B Rv0867c|RPFA (N-terminal part)%2C Rv2450c|RPFE%2C and Rv1009|RPFB (C-terminal part). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpfC;locus_tag=Rv1884c;product=Probable resuscitation-promoting factor RpfC;protein_id=CCP44650.1;transl_table=11
AL123456.3	EMBL	gene	2134273	2134872	.	-	.	ID=gene-Rv1885c;Name=Rv1885c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1885c
AL123456.3	EMBL	CDS	2134273	2134872	.	-	0	ID=cds-CCP44651.1;Parent=gene-Rv1885c;Dbxref=EnsemblGenomes-Gn:Rv1885c,EnsemblGenomes-Tr:CCP44651,GOA:P9WIB9,InterPro:IPR002701,InterPro:IPR008240,InterPro:IPR020822,PDB:2AO2,PDB:2F6L,PDB:2FP1,PDB:2FP2,NCBI_GP:CCP44651.1;Name=CCP44651.1;Note=Rv1885c%2C (MTCY180.33)%2C len: 199 aa. Chorismate mutase%2C AroQ class (See Prakash et al.%2C 2005%2C Sasso et al.%2C2005)%2C some similarity to P42517|CHMU_ERWHE monofunctional chorismate mutase (181 aa)%2C FASTA score: opt: 181%2C E(): 0.00017%2C (28.6%25 identity in 133 aa overlap). Contains N-terminal signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1885c;product=Chorismate mutase;protein_id=CCP44651.1;transl_table=11
AL123456.3	EMBL	gene	2134890	2135867	.	-	.	ID=gene-Rv1886c;Name=fbpB;gbkey=Gene;gene=fbpB;gene_biotype=protein_coding;gene_synonym=85B,mpt59;locus_tag=Rv1886c
AL123456.3	EMBL	CDS	2134890	2135867	.	-	0	ID=cds-CCP44652.1;Parent=gene-Rv1886c;Dbxref=EnsemblGenomes-Gn:Rv1886c,EnsemblGenomes-Tr:CCP44652,GOA:P9WQP1,InterPro:IPR000801,InterPro:IPR029058,PDB:1F0N,PDB:1F0P,NCBI_GP:CCP44652.1;Name=CCP44652.1;Note=Rv1886c%2C (MT1934%2C MTCY180.32)%2C len: 325 aa. FbpB (alternate gene names: mpt59%2C 85B)%2C precursor of the 85-B antigen (fibronectin-binding protein B) (mycolyl transferase 85B) (see citations below)%2C highly similar to other Mycobacterial antigen precursors e.g. P12942|A85B_MYCBO antigen 85-B precursor from Mycobacterium bovis (323 aa)%3B P21160|A85B_MYCKA antigen 85-B precursor from Mycobacterium kansasii (325 aa)%3B etc. Also highly similar to Mycobacterium tuberculosis antigen precursors: Rv3804c|fbpA (338 aa)%2C Rv0129c|fbpC2 (340 aa)%2C and Rv3803c|fbpC1 (299 aa). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fbpB;locus_tag=Rv1886c;product=Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen);protein_id=CCP44652.1;transl_table=11
AL123456.3	EMBL	gene	2136258	2137400	.	+	.	ID=gene-Rv1887;Name=Rv1887;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1887
AL123456.3	EMBL	CDS	2136258	2137400	.	+	0	ID=cds-CCP44653.1;Parent=gene-Rv1887;Dbxref=EnsemblGenomes-Gn:Rv1887,EnsemblGenomes-Tr:CCP44653,GOA:O07745,UniProtKB/TrEMBL:O07745,NCBI_GP:CCP44653.1;Name=CCP44653.1;Note=Rv1887%2C (MTCY180.31)%2C len: 380 aa. Hypothetical unknown protein%3B contains eukaryotic thiol (cysteine) proteases histidine active site at N-terminus (PS00639) and Pro-rich region near C-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00639;locus_tag=Rv1887;product=Hypothetical protein;protein_id=CCP44653.1;transl_table=11
AL123456.3	EMBL	gene	2137519	2138079	.	-	.	ID=gene-Rv1888c;Name=Rv1888c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1888c
AL123456.3	EMBL	CDS	2137519	2138079	.	-	0	ID=cds-CCP44654.1;Parent=gene-Rv1888c;Dbxref=EnsemblGenomes-Gn:Rv1888c,EnsemblGenomes-Tr:CCP44654,GOA:O07744,InterPro:IPR025498,UniProtKB/TrEMBL:O07744,NCBI_GP:CCP44654.1;Name=CCP44654.1;Note=Rv1888c%2C (MTCY180.30)%2C len: 186 aa. Possible transmembrane protein.;gbkey=CDS;locus_tag=Rv1888c;product=Possible transmembrane protein;protein_id=CCP44654.1;transl_table=11
AL123456.3	EMBL	gene	2138444	2138617	.	-	.	ID=gene-Rv1888A;Name=Rv1888A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1888A
AL123456.3	EMBL	CDS	2138444	2138617	.	-	0	ID=cds-CCP44655.1;Parent=gene-Rv1888A;Dbxref=EnsemblGenomes-Gn:Rv1888A,EnsemblGenomes-Tr:CCP44655,GOA:Q79FJ0,InterPro:IPR007213,InterPro:IPR029063,UniProtKB/TrEMBL:Q79FJ0,NCBI_GP:CCP44655.1;Name=CCP44655.1;Note=Rv1888A%2C len: 57 aa. Conserved hypothetical protein. Possibly continuation of Rv1889c%2C part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~~ 120 aa. Includes: C-terminus of Rv0726c|P95074 conserved hypothetical protein (367 aa)%2CFASTA scores: opt: 295%2C E(): 3.1e-15%2C (73.684%25 identity in 57 aa overlap)%3B C-terminus of Rv3399|Q50726|MTCY78.29c conserved hypothetical protein (348 aa)%2C FASTA scores: opt: 504%2C E(): 7.3e-29%2C (64.2%25 identity in 120 aa overlap)%3B C-terminus of Rv0731c%3B etc.;gbkey=CDS;locus_tag=Rv1888A;product=Conserved hypothetical protein;protein_id=CCP44655.1;transl_table=11
AL123456.3	EMBL	gene	2138661	2139017	.	-	.	ID=gene-Rv1889c;Name=Rv1889c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1889c
AL123456.3	EMBL	CDS	2138661	2139017	.	-	0	ID=cds-CCP44656.1;Parent=gene-Rv1889c;Dbxref=EnsemblGenomes-Gn:Rv1889c,EnsemblGenomes-Tr:CCP44656,GOA:O07743,InterPro:IPR007213,InterPro:IPR029063,UniProtKB/TrEMBL:O07743,NCBI_GP:CCP44656.1;Name=CCP44656.1;Note=Rv1889c%2C (MTCY180.29)%2C len: 118 aa. Conserved hypothetical protein. Part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~~120 aa. Includes: Rv3399|Q50726|MTCY78.29C conserved hypothetical protein (348 aa)%2C FASTA results: opt: 504%2CE(): 7.3e-29%2C (64.2%25 identity in 120 aa overlap)%3B Rv0726c|P95074%3B Rv0731c%3B etc. Rv1888A possibly continuation of this CDS.;gbkey=CDS;locus_tag=Rv1889c;product=Conserved hypothetical protein;protein_id=CCP44656.1;transl_table=11
AL123456.3	EMBL	gene	2139076	2139687	.	-	.	ID=gene-Rv1890c;Name=Rv1890c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1890c
AL123456.3	EMBL	CDS	2139076	2139687	.	-	0	ID=cds-CCP44657.1;Parent=gene-Rv1890c;Dbxref=EnsemblGenomes-Gn:Rv1890c,EnsemblGenomes-Tr:CCP44657,GOA:O07742,InterPro:IPR007372,UniProtKB/TrEMBL:O07742,NCBI_GP:CCP44657.1;Name=CCP44657.1;Note=Rv1890c%2C (MTCY180.28)%2C len: 203 aa. Hypothetical unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1890c;product=Hypothetical protein;protein_id=CCP44657.1;transl_table=11
AL123456.3	EMBL	gene	2139419	2139656	.	+	.	ID=gene-AS1890;Name=AS1890;gbkey=Gene;gene=AS1890;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	2139419	2139656	.	+	.	ID=rna-AS1890;Parent=gene-AS1890;Note=AS1890%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 2139466%2C2139548%2C 2139594.;gbkey=ncRNA;gene=AS1890;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	2139419	2139656	.	+	.	ID=exon-AS1890-1;Parent=rna-AS1890;Note=AS1890%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 2139466%2C2139548%2C 2139594.;gbkey=ncRNA;gene=AS1890;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	2139741	2140148	.	+	.	ID=gene-Rv1891;Name=Rv1891;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1891
AL123456.3	EMBL	CDS	2139741	2140148	.	+	0	ID=cds-CCP44658.1;Parent=gene-Rv1891;Dbxref=EnsemblGenomes-Gn:Rv1891,EnsemblGenomes-Tr:CCP44658,GOA:O07741,UniProtKB/TrEMBL:O07741,NCBI_GP:CCP44658.1;Name=CCP44658.1;Note=Rv1891%2C (MTCY180.27c)%2C len: 135 aa. Conserved protein. Equivalent to MLCB561.09|AL049571 hypothetical protein from Mycobacterium leprae (134 aa)%2C FASTA scores: opt: 800%2C E(): 0%2C (79.7%25 identity in 133 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1891;product=Conserved protein;protein_id=CCP44658.1;transl_table=11
AL123456.3	EMBL	gene	2140165	2140476	.	+	.	ID=gene-Rv1892;Name=Rv1892;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1892
AL123456.3	EMBL	CDS	2140165	2140476	.	+	0	ID=cds-CCP44659.1;Parent=gene-Rv1892;Dbxref=EnsemblGenomes-Gn:Rv1892,EnsemblGenomes-Tr:CCP44659,UniProtKB/TrEMBL:O07740,NCBI_GP:CCP44659.1;Name=CCP44659.1;Note=Rv1892%2C (MTCY180.26c)%2C len: 103 aa. Probable membrane protein.;gbkey=CDS;locus_tag=Rv1892;product=Probable membrane protein;protein_id=CCP44659.1;transl_table=11
AL123456.3	EMBL	gene	2140486	2140704	.	+	.	ID=gene-Rv1893;Name=Rv1893;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1893
AL123456.3	EMBL	CDS	2140486	2140704	.	+	0	ID=cds-CCP44660.1;Parent=gene-Rv1893;Dbxref=EnsemblGenomes-Gn:Rv1893,EnsemblGenomes-Tr:CCP44660,UniProtKB/TrEMBL:O07739,NCBI_GP:CCP44660.1;Name=CCP44660.1;Note=Rv1893%2C (MTCY180.25c)%2C len: 72 aa. Conserved hypothetical protein. Equivalent to MLCB561.11|AL049571 hypothetical protein from Mycobacterium leprae (74 aa)%2CFASTA scores: opt: 317%2C E(): 4.6e-15%2C (69.4%25 identity in 72 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1893;product=Conserved hypothetical protein;protein_id=CCP44660.1;transl_table=11
AL123456.3	EMBL	gene	2140739	2141869	.	-	.	ID=gene-Rv1894c;Name=Rv1894c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1894c
AL123456.3	EMBL	CDS	2140739	2141869	.	-	0	ID=cds-CCP44661.1;Parent=gene-Rv1894c;Dbxref=EnsemblGenomes-Gn:Rv1894c,EnsemblGenomes-Tr:CCP44661,GOA:O07738,InterPro:IPR004136,InterPro:IPR013785,UniProtKB/TrEMBL:O07738,NCBI_GP:CCP44661.1;Name=CCP44661.1;Note=Rv1894c%2C (MTCY180.24)%2C len: 376 aa. Conserved hypothetical protein%2C weak similarity to some oxidoreductases e.g. Q01284 2-nitropropane dioxygenase precursor (378 aa)%2C FASTA results: opt: 204%2C E(): 5.8e-06%2C(34.3%25 identity in 140 aa overlap). Similar to hypothetical Mycobacterium tuberculosis proteins e.g. Rv3553|MTCY03C7.02c (355 aa)%2C FASTA results: opt: 296%2C E(): 1.6e-10%2C (32.9%25 identity in 167 aa overlap)%3B Rv1533 (375 aa) (48.1%25 identity in 376 aa overlap)%3B Rv0021c%2C Rv2781c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1894c;product=Conserved hypothetical protein;protein_id=CCP44661.1;transl_table=11
AL123456.3	EMBL	gene	2142521	2143675	.	+	.	ID=gene-Rv1895;Name=Rv1895;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1895
AL123456.3	EMBL	CDS	2142521	2143675	.	+	0	ID=cds-CCP44662.1;Parent=gene-Rv1895;Dbxref=EnsemblGenomes-Gn:Rv1895,EnsemblGenomes-Tr:CCP44662,GOA:O07737,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,NCBI_GP:CCP44662.1;Name=CCP44662.1;Note=Rv1895%2C (MTCY180.23c)%2C len: 384 aa. Possible dehydrogenase%2C similar to various sorbitol and alcohol dehydrogenases%2C and to putative glutathione-dependent aldehyde dehydrogenase e.g DHSO_BACSU|Q06004 Sorbitol dehydrogenase from Streptomyces coelicolor (352 aa)%2C FASTA results: opt: 506%2C E(): 7.2e-24%2C (30.6%25 identity in 350 aa overlap)%3B and AL109962|SCJ1.28 putative zinc-containing dehydrogenase from Streptomyces coelicolor (356 aa)%2C FASTA results: opt: 634%2C E(): 2.9e-30%2C (34.7%25 identity in 357 aa overlap). Also similar to other Mycobacterium tuberculosis dehydrogenases. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF%2C although both appear to be true coding regions.;gbkey=CDS;locus_tag=Rv1895;product=Possible dehydrogenase;protein_id=CCP44662.1;transl_table=11
AL123456.3	EMBL	gene	2143535	2144446	.	-	.	ID=gene-Rv1896c;Name=Rv1896c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1896c
AL123456.3	EMBL	CDS	2143535	2144446	.	-	0	ID=cds-CCP44663.1;Parent=gene-Rv1896c;Dbxref=EnsemblGenomes-Gn:Rv1896c,EnsemblGenomes-Tr:CCP44663,GOA:P9WFH7,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP44663.1;Name=CCP44663.1;Note=Rv1896c%2C (MTCY180.22)%2C len: 303 aa. Conserved hypothetical protein. Similar to several (14) hypothetical Mycobacterium tuberculosis proteins e.g. Rv0145|MTCI5.19 (317 aa)%2C FASTA results: opt: 720%2C E(): 0%2C (41.6%25 identity in 308 aa overlap)%3B Q10552|YZ21_MYCTU (325 aa)%2C opt: 689%2CE(): 0%2C (40.5%25 identity in 304 aa overlap)%3B Rv0726c%2CRv0731c%2C Rv3399%2C etc. and to related proteins in other actinomycetes. Note that there is a substantial (134 bp) overlap at the C-terminus with the C-terminus of the downstream ORF%2C although both appear to be true coding regions.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1896c;product=Conserved hypothetical protein;protein_id=CCP44663.1;transl_table=11
AL123456.3	EMBL	gene	2144451	2144882	.	-	.	ID=gene-Rv1897c;Name=Rv1897c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1897c
AL123456.3	EMBL	CDS	2144451	2144882	.	-	0	ID=cds-CCP44664.1;Parent=gene-Rv1897c;Dbxref=EnsemblGenomes-Gn:Rv1897c,EnsemblGenomes-Tr:CCP44664,GOA:P9WNS9,InterPro:IPR003732,InterPro:IPR023509,NCBI_GP:CCP44664.1;Name=CCP44664.1;Note=Rv1897c%2C (MTCY180.21)%2C len: 143 aa. Conserved hypothetical protein. Some similarity to D63706|Q54235 ORF2 from Streptomyces griseus (149 aa)%2C FASTA results: opt: 509%2C E(): 1.2e-28%2C (57.3%25 identity in 150 aa overlap)%3B and Q45303 ORF1 protein from Corynebacterium glutamicum (144 aa)%2C FASTA results: opt: 460%2C E(): 5.5e-23%2C (49.7%25 identity in 143 aa overlap).;gbkey=CDS;locus_tag=Rv1897c;product=Conserved hypothetical protein;protein_id=CCP44664.1;transl_table=11
AL123456.3	EMBL	gene	2144940	2145248	.	+	.	ID=gene-Rv1898;Name=Rv1898;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1898
AL123456.3	EMBL	CDS	2144940	2145248	.	+	0	ID=cds-CCP44665.1;Parent=gene-Rv1898;Dbxref=EnsemblGenomes-Gn:Rv1898,EnsemblGenomes-Tr:CCP44665,InterPro:IPR002767,InterPro:IPR029756,NCBI_GP:CCP44665.1;Name=CCP44665.1;Note=Rv1898%2C (MTCY180.20c)%2C len: 102 aa. Conserved hypothetical protein%2C some similarity to other hypothetical proteins e.g. Q58452 from methanococcus jannasch II (100 aa)%2C FASTA results: opt: 152%2C E(): 9.1e-05%2C (31.5%25 identity in 92 aa overlap)%3B and AE000771|AE000771_2 from Aquifex aeolicus (157 aa)%2C FASTA results: opt: 246%2C E(): 3.2e-11%2C(39.0%25 identity in 100 aa overlap).;gbkey=CDS;locus_tag=Rv1898;product=Conserved hypothetical protein;protein_id=CCP44665.1;transl_table=11
AL123456.3	EMBL	gene	2145214	2146245	.	-	.	ID=gene-Rv1899c;Name=lppD;gbkey=Gene;gene=lppD;gene_biotype=protein_coding;locus_tag=Rv1899c
AL123456.3	EMBL	CDS	2145214	2146245	.	-	0	ID=cds-CCP44666.1;Parent=gene-Rv1899c;Dbxref=EnsemblGenomes-Gn:Rv1899c,EnsemblGenomes-Tr:CCP44666,GOA:P9WK29,InterPro:IPR002589,NCBI_GP:CCP44666.1;Name=CCP44666.1;Note=Rv1899c%2C (MTCY180.19)%2C len: 343 aa. Possible lipoprotein%3B contains appropriately localized lipoprotein lipid attachment site (PS00013). Some similarity to C-terminal part of AE000717|AE000717_4 hypothetical protein from Aquifex aeolicus section 49 (165 aa)%2C FASTA results: opt: 372%2C E(): 2.3e-14%2C (43.5%25 identity in 147 aa overlap)%3B and Q44020 4-hydroxybutyrate dehydrogenase (173 aa)%2C FASTA results: opt: 272%2C E(): 4.7e-09%2C (35.8%25 identity in 165 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppD;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1899c;product=Possible lipoprotein LppD;protein_id=CCP44666.1;transl_table=11
AL123456.3	EMBL	gene	2146245	2147633	.	-	.	ID=gene-Rv1900c;Name=lipJ;gbkey=Gene;gene=lipJ;gene_biotype=protein_coding;locus_tag=Rv1900c
AL123456.3	EMBL	CDS	2146245	2147633	.	-	0	ID=cds-CCP44667.1;Parent=gene-Rv1900c;Dbxref=EnsemblGenomes-Gn:Rv1900c,EnsemblGenomes-Tr:CCP44667,GOA:O07732,InterPro:IPR001054,InterPro:IPR029058,InterPro:IPR029787,PDB:1YBT,PDB:1YBU,UniProtKB/TrEMBL:O07732,NCBI_GP:CCP44667.1;Name=CCP44667.1;Note=Rv1900c%2C (MTCY180.18)%2C len: 462 aa. Probable lipJ%2Clignin peroxidase%2C with some similarity to esterases%2Chydrolases and hypothetical Mycobacterium tuberculosis proteins e.g. Q43936 beta-ketoadipate enol-lactone hydrolase from Acinetobacter calcoaceticus (267 aa)%2C FASTA results: opt: 217%2C E(): 1.7e-07%2C (29.2%25 identity in 260 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv2212|Q10400|YM12_MYCTU (378 aa)%2C FASTA results: opt: 216%2C E(): 6.7e-07%2C (27.7%25 identity in 285 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipJ;locus_tag=Rv1900c;product=Probable lignin peroxidase LipJ;protein_id=CCP44667.1;transl_table=11
AL123456.3	EMBL	gene	2147662	2148954	.	+	.	ID=gene-Rv1901;Name=cinA;gbkey=Gene;gene=cinA;gene_biotype=protein_coding;locus_tag=Rv1901
AL123456.3	EMBL	CDS	2147662	2148954	.	+	0	ID=cds-CCP44668.1;Parent=gene-Rv1901;Dbxref=EnsemblGenomes-Gn:Rv1901,EnsemblGenomes-Tr:CCP44668,GOA:P9WPE3,InterPro:IPR001453,InterPro:IPR008135,InterPro:IPR008136,NCBI_GP:CCP44668.1;Name=CCP44668.1;Note=Rv1901%2C (MTCY180.17c)%2C len: 430 aa. Probable cinA-like protein%2C strong similarity to competence damage proteins CinA of Bacillus subtilis and S. pneumoniae. FASTA results: Q55760 hypothetical 44.7 kDa protein (416 aa) opt: 755%2C E(): 0%2C (36.0%25 identity in 433 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cinA;locus_tag=Rv1901;product=Probable CinA-like protein CinA;protein_id=CCP44668.1;transl_table=11
AL123456.3	EMBL	gene	2149006	2150274	.	-	.	ID=gene-Rv1902c;Name=nanT;gbkey=Gene;gene=nanT;gene_biotype=protein_coding;locus_tag=Rv1902c
AL123456.3	EMBL	CDS	2149006	2150274	.	-	0	ID=cds-CCP44669.1;Parent=gene-Rv1902c;Dbxref=EnsemblGenomes-Gn:Rv1902c,EnsemblGenomes-Tr:CCP44669,GOA:O07730,InterPro:IPR004742,InterPro:IPR005828,InterPro:IPR005829,InterPro:IPR016196,InterPro:IPR020846,UniProtKB/TrEMBL:O07730,NCBI_GP:CCP44669.1;Name=CCP44669.1;Note=Rv1902c%2C (MTCY180.16)%2C len: 422 aa. Probable nanT%2Csialic acid-transport integral membrane protein%2C possibly member of major facilitator superfamily (MFS)%2C similar to others e.g. Q48076 sialic acid transporter (407 aa)%2C FASTA results: opt: 443%2C E(): 5.4e-22%2C (26.7%25 identity in 389 aa overlap)%3B etc. Some similarity to MTCI364.12|O05301 conserved hypothetical protein from Mycobacterium tuberculosis (425 aa)%2C FASTA results: opt: 251%2C E(): 1.1e-09%2C (23.5%25 identity in 417 aa overlap). Contains sugar transport proteins signature 2 (PS00217).;gbkey=CDS;gene=nanT;inference=protein motif:PROSITE:PS00217;locus_tag=Rv1902c;product=Probable sialic acid-transport integral membrane protein NanT;protein_id=CCP44669.1;transl_table=11
AL123456.3	EMBL	gene	2150364	2150768	.	+	.	ID=gene-Rv1903;Name=Rv1903;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1903
AL123456.3	EMBL	CDS	2150364	2150768	.	+	0	ID=cds-CCP44670.1;Parent=gene-Rv1903;Dbxref=EnsemblGenomes-Gn:Rv1903,EnsemblGenomes-Tr:CCP44670,InterPro:IPR007165,UniProtKB/TrEMBL:O07729,NCBI_GP:CCP44670.1;Name=CCP44670.1;Note=Rv1903%2C (MTCY180.15c)%2C len: 134 aa. Probable conserved membrane protein%2C similar to Q53868|YPT3_STRCO hypothetical 15.9 kDa protein from Streptomyces coelicolor (148 aa) opt: 323%2C E(): 1.3e-16%2C (42.9%25 identity in 126 aa overlap)%3B and equivalent to AJ000521|MLCOSL672_3 from Mycobacterium leprae (139 aa)%2C FASTA results: opt: 680%2CE(): 0%2C (80.6%25 identity in 129 aa overlap).;gbkey=CDS;locus_tag=Rv1903;product=Probable conserved membrane protein;protein_id=CCP44670.1;transl_table=11
AL123456.3	EMBL	gene	2150954	2151385	.	+	.	ID=gene-Rv1904;Name=Rv1904;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1904
AL123456.3	EMBL	CDS	2150954	2151385	.	+	0	ID=cds-CCP44671.1;Parent=gene-Rv1904;Dbxref=EnsemblGenomes-Gn:Rv1904,EnsemblGenomes-Tr:CCP44671,GOA:O07728,InterPro:IPR002645,InterPro:IPR003658,UniProtKB/TrEMBL:O07728,NCBI_GP:CCP44671.1;Name=CCP44671.1;Note=Rv1904%2C (MTCY180.14c)%2C len: 143 aa. Conserved hypothetical protein%2C some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08|P71937 (148 aa)%2C FASTA results: opt: 456%2CE(): 2.7e-23%2C (52.8%25 identity in 125 aa overlap)%3B Rv1365|Q11035 (128 aa)%2C FASTA results: opt: 393%2C E(): 1.4e-19%2C (48.8%25 identity in 123 aa overlap)%3B and Rv3687c. Also weak similarity to Q9WVX8|RSBV_STRCO anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa).;gbkey=CDS;locus_tag=Rv1904;product=Conserved hypothetical protein;protein_id=CCP44671.1;transl_table=11
AL123456.3	EMBL	gene	2151433	2152395	.	-	.	ID=gene-Rv1905c;Name=aao;gbkey=Gene;gene=aao;gene_biotype=protein_coding;locus_tag=Rv1905c
AL123456.3	EMBL	CDS	2151433	2152395	.	-	0	ID=cds-CCP44672.1;Parent=gene-Rv1905c;Dbxref=EnsemblGenomes-Gn:Rv1905c,EnsemblGenomes-Tr:CCP44672,GOA:P9WP27,InterPro:IPR006076,InterPro:IPR016040,InterPro:IPR023209,NCBI_GP:CCP44672.1;Name=CCP44672.1;Note=Rv1905c%2C (MTCY180.13)%2C len: 320 aa. Probable aao%2CD-amino acid oxidase%2C similar to many. Equivalent to AJ000521|MLCOSL672.02|O33145 Mycobacterium leprae (320 aa)%2CFASTA results: opt: 1541%2C E(): 0%2C (71.7%25 identity in 315 aa overlap)%3B also similar to OXDD_BOVIN|P31228 d-aspartate oxidase from bos taurus (338 aa)%2C FASTA results: opt: 461%2CE(): 1.1e-21%2C (31.8%25 identity in 321 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aao;locus_tag=Rv1905c;product=Probable D-amino acid oxidase Aao;protein_id=CCP44672.1;transl_table=11
AL123456.3	EMBL	gene	2152425	2152895	.	-	.	ID=gene-Rv1906c;Name=Rv1906c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1906c
AL123456.3	EMBL	CDS	2152425	2152895	.	-	0	ID=cds-CCP44673.1;Parent=gene-Rv1906c;Dbxref=EnsemblGenomes-Gn:Rv1906c,EnsemblGenomes-Tr:CCP44673,GOA:O07726,UniProtKB/TrEMBL:O07726,NCBI_GP:CCP44673.1;Name=CCP44673.1;Note=Rv1906c%2C (MTCY180.12)%2C len: 156 aa. Conserved protein%2C possibly exported protein%2C equivalent to Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa)%2C FASTA scores: opt: 637%2C E(): 2.6e-28%2C (63.2%25 identity in 155 aa overlap). Also similar to M. tuberculosis hypothetical exported protein%2C Rv1352. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1906c;product=Conserved protein;protein_id=CCP44673.1;transl_table=11
AL123456.3	EMBL	gene	2153235	2153882	.	-	.	ID=gene-Rv1907c;Name=Rv1907c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1907c
AL123456.3	EMBL	CDS	2153235	2153882	.	-	0	ID=cds-CCP44674.1;Parent=gene-Rv1907c;Dbxref=EnsemblGenomes-Gn:Rv1907c,EnsemblGenomes-Tr:CCP44674,InterPro:IPR025358,UniProtKB/TrEMBL:L0TAY1,NCBI_GP:CCP44674.1;Name=CCP44674.1;Note=Rv1907c%2C (MTCY180.11)%2C len: 215 aa. Hypothetical unknown protein. Similar to Q50763 Ethyl methane sulphonate resistance protein from Mycobacterium tuberculosis (168 aa)%2C FASTA scores: opt: 638%2C E(): 0%2C (69.7%25 identity in 152 aa overlap). Downstream of a cloned katG gene (EMBL:mtkatg). Differences are due to frameshift errors in the EMBL sequence and the use of an earlier start codon. Alternative nucleotide at position 2153410 (a->G%3B V158A) has been observed.;gbkey=CDS;locus_tag=Rv1907c;product=Hypothetical protein;protein_id=CCP44674.1;transl_table=11
AL123456.3	EMBL	gene	2153889	2156111	.	-	.	ID=gene-Rv1908c;Name=katG;gbkey=Gene;gene=katG;gene_biotype=protein_coding;locus_tag=Rv1908c
AL123456.3	EMBL	CDS	2153889	2156111	.	-	0	ID=cds-CCP44675.1;Parent=gene-Rv1908c;Dbxref=EnsemblGenomes-Gn:Rv1908c,EnsemblGenomes-Tr:CCP44675,GOA:P9WIE5,InterPro:IPR000763,InterPro:IPR002016,InterPro:IPR010255,InterPro:IPR019793,InterPro:IPR019794,PDB:1SFZ,PDB:1SJ2,PDB:2CCA,PDB:2CCD,PDB:4C50,PDB:4C51,NCBI_GP:CCP44675.1;Name=CCP44675.1;Note=Rv1908c%2C (MTCY180.10)%2C len: 740 aa. KatG%2Ccatalase-peroxidase-peroxynitritase T (see citations below)%2C HPI. FASTA results: Q57215 catalase-peroxidase from Mycobacterium tuberculosis (740 aa) opt: 5081%2C E(): 0%2C(100%25 identity in 740 aa overlap). Contains peroxidases active site signature (PS00436) and ATP/GTP-binding site motif A (P-loop%3B PS00017). Cosmid sequence was corrected to agree with a sequencing read from the H37Rv genome. Deletions or defects in KATG gene cause isoniazid (INH) resistance. Belongs to the peroxidase family. Bacterial peroxidase/catalase subfamily. KATG transcription seems to be regulated by FURA|Rv1909c product. The catalase-peroxidase activity is associated with the amino-terminal domain but no definite function has been assigned to the carboxy-terminal domain. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=katG;inference=protein motif:PROSITE:PS00436;locus_tag=Rv1908c;product=Catalase-peroxidase-peroxynitritase T KatG;protein_id=CCP44675.1;transl_table=11
AL123456.3	EMBL	gene	2156149	2156592	.	-	.	ID=gene-Rv1909c;Name=furA;gbkey=Gene;gene=furA;gene_biotype=protein_coding;locus_tag=Rv1909c
AL123456.3	EMBL	CDS	2156149	2156592	.	-	0	ID=cds-CCP44676.1;Parent=gene-Rv1909c;Dbxref=EnsemblGenomes-Gn:Rv1909c,EnsemblGenomes-Tr:CCP44676,GOA:P9WN87,InterPro:IPR002481,InterPro:IPR011991,NCBI_GP:CCP44676.1;Name=CCP44676.1;Note=Rv1909c%2C (MTCY180.09)%2C len: 147 aa. FurA%2C Ferric uptake regulation protein%2C similar to Q48835 legionella pneumophila 130B (wadsworth) ferric uptake regulation (136 aa)%2C FASTA results: opt: 230%2C E(): 2.5e-09%2C (32.3%25 identity in 133 aa overlap). Also similar to Mycobacterium tuberculosis zur zinc uptake regulatory protein%2C Rv2359. Belongs to the fur family. Start changed since original submission (-3 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=furA;locus_tag=Rv1909c;product=Ferric uptake regulation protein FurA (fur);protein_id=CCP44676.1;transl_table=11
AL123456.3	EMBL	gene	2156706	2157299	.	-	.	ID=gene-Rv1910c;Name=Rv1910c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1910c
AL123456.3	EMBL	CDS	2156706	2157299	.	-	0	ID=cds-CCP44677.1;Parent=gene-Rv1910c;Dbxref=EnsemblGenomes-Gn:Rv1910c,EnsemblGenomes-Tr:CCP44677,GOA:P9WFN5,InterPro:IPR008914,NCBI_GP:CCP44677.1;Name=CCP44677.1;Note=Rv1910c%2C (MTCY180.08)%2C len: 197 aa. Possible exported protein%2C very similar to upstream ORF MTCY180.07 (201 aa)%2C FASTA score: E(): 0%2C (64.0%25 identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN protein CPN0877 from Chlamydophila pneumoniae (150 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1910c;product=Probable exported protein;protein_id=CCP44677.1;transl_table=11
AL123456.3	EMBL	gene	2157382	2157987	.	-	.	ID=gene-Rv1911c;Name=lppC;gbkey=Gene;gene=lppC;gene_biotype=protein_coding;locus_tag=Rv1911c
AL123456.3	EMBL	CDS	2157382	2157987	.	-	0	ID=cds-CCP44678.1;Parent=gene-Rv1911c;Dbxref=EnsemblGenomes-Gn:Rv1911c,EnsemblGenomes-Tr:CCP44678,GOA:P9WFN3,InterPro:IPR005247,InterPro:IPR008914,NCBI_GP:CCP44678.1;Name=CCP44678.1;Note=Rv1911c%2C (MTCY180.07)%2C len: 201 aa. Probable lipoprotein lppC%2C contains appropriately positioned prokaryotic membrane lipoprotein lipid attachment site (PS00013). Very similar to downstream ORF MTCY180.08 (204 aa) (although this lacks lipoprotein motif)%2C FASTA score: opt: 831%2C E(): 0%2C (64.0%25 identity in 200 aa overlap). Also similar to Q9Z729|Y877_CHLPN hypothetical protein CPN0877 from Chlamydia pneumoniae (strain CWL029) (150 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppC;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1911c;product=Probable lipoprotein LppC;protein_id=CCP44678.1;transl_table=11
AL123456.3	EMBL	gene	2158087	2159091	.	-	.	ID=gene-Rv1912c;Name=fadB5;gbkey=Gene;gene=fadB5;gene_biotype=protein_coding;locus_tag=Rv1912c
AL123456.3	EMBL	CDS	2158087	2159091	.	-	0	ID=cds-CCP44679.1;Parent=gene-Rv1912c;Dbxref=EnsemblGenomes-Gn:Rv1912c,EnsemblGenomes-Tr:CCP44679,GOA:O07721,InterPro:IPR002085,InterPro:IPR002364,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,UniProtKB/TrEMBL:O07721,NCBI_GP:CCP44679.1;Name=CCP44679.1;Note=Rv1912c%2C (MTCY180.06)%2C len: 334 aa. Possible fadB5%2Coxidoreductase%2C similar to various oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase%2C quinone oxidoreductases%2Cand polyketide synthases%2C e.g. NP_104067.1|NC_002678 probable oxidoreductase from Mesorhizobium loti (308 aa)%3B NP_464140.1|NC_003210 protein similar to oxidoreductase from Listeria monocytogenes (313 aa)%3B NP_193889.1|NC_003075 putative NADPH quinone oxidoreductase from Arabidopsis thaliana (325 aa)%3B NP_001880.2|NM_001889 crystallin%2C zeta%3B quinone oxidoreductase%3B NADPH:quinone reductase from Homo sapiens (329 aa)%3B part 2983 to 3197 of T17410 polyketide synthase type I from Streptomyces venezuelae (3739 aa)%3B Q53927|SCBAC20F6.16 hydroxyacyl-CoA dehydrogenase from Streptomyces coelicolor (329 aa)%2C FASTA scores: opt: 621%2CE(): 2e-30%2C (39.5%25 identity in 349 aa overlap)%3B etc. Also similar to many hypothetical Mycobacterium tuberculosis proteins including: MTCY24G1.09%2C MTCY13D12.11%2C MTCY19H9.01%2CMTCY24G1.03%2C MTCY03A2.17c%2C etc. Contains quinone oxidoreductase/zeta-crystallin signature (PS01162).;gbkey=CDS;gene=fadB5;inference=protein motif:PROSITE:PS01162;locus_tag=Rv1912c;product=Possible oxidoreductase FadB5;protein_id=CCP44679.1;transl_table=11
AL123456.3	EMBL	gene	2159191	2159943	.	+	.	ID=gene-Rv1913;Name=Rv1913;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1913
AL123456.3	EMBL	CDS	2159191	2159943	.	+	0	ID=cds-CCP44680.1;Parent=gene-Rv1913;Dbxref=EnsemblGenomes-Gn:Rv1913,EnsemblGenomes-Tr:CCP44680,InterPro:IPR001279,UniProtKB/TrEMBL:O07720,NCBI_GP:CCP44680.1;Name=CCP44680.1;Note=Rv1913%2C (MTCY180.05c)%2C len: 250 aa. Conserved hypothetical protein%2C slight similarity to dehydrase and beta-lactamase precursors e.g. Q02057 dehydrase from Streptomyces coelicolor (297 aa)%2C FASTA scores: opt: 184%2CE(): 4.3e-05%2C (31.6%25 identity in 215 aa overlap).;gbkey=CDS;locus_tag=Rv1913;product=Conserved hypothetical protein;protein_id=CCP44680.1;transl_table=11
AL123456.3	EMBL	gene	2159921	2160328	.	-	.	ID=gene-Rv1914c;Name=Rv1914c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1914c
AL123456.3	EMBL	CDS	2159921	2160328	.	-	0	ID=cds-CCP44681.1;Parent=gene-Rv1914c;Dbxref=EnsemblGenomes-Gn:Rv1914c,EnsemblGenomes-Tr:CCP44681,GOA:O07719,UniProtKB/TrEMBL:O07719,NCBI_GP:CCP44681.1;Name=CCP44681.1;Note=Rv1914c%2C (MTCY180.04)%2C len: 135 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1914c;product=Unknown protein;protein_id=CCP44681.1;transl_table=11
AL123456.3	EMBL	gene	2160463	2161566	.	+	.	ID=gene-Rv1915;Name=aceAa;gbkey=Gene;gene=aceAa;gene_biotype=protein_coding;gene_synonym=icl2a;locus_tag=Rv1915
AL123456.3	EMBL	CDS	2160463	2161566	.	+	0	ID=cds-CCP44682.1;Parent=gene-Rv1915;Dbxref=EnsemblGenomes-Gn:Rv1915,EnsemblGenomes-Tr:CCP44682,GOA:O07718,InterPro:IPR006254,InterPro:IPR015813,InterPro:IPR018523,UniProtKB/TrEMBL:O07718,NCBI_GP:CCP44682.1;Name=CCP44682.1;Note=Rv1915%2C (MTCY180.03c)%2C len: 367 aa. Probable aceAa%2Cisocitrate lyase (see citations below). Highly similar to the N-terminus of ACEA_MYCLE isocitrate lyase from Mycobacterium leprae (606 aa)%2C FASTA results: opt: 3314%2CE(): 0%2C (86.5%25 identity in 572 aa overlap). Contains PS00161 Isocitrate lyase signature. Although this ORF and the downstream ORF representing the C-terminal half of aceA could be joined by a frameshift%2C no error is apparent in the cosmid%2C or in a seqencing read from the genome of H37Rv. As the downstream ORF has a RBS and transcriptional start immediately following the stop of this ORF%2C it is possible that they are expressed as two separate modules. In Mycobacterium tuberculosis strain CDC1551%2C aceA exists as a single gene%2C MT1966: the corresponding protein has been purified experimentally and seems have an active isocitrate lyase activity (see Honer et al.%2C 1999). For Mycobacterium tuberculosis strain H37Rv%2C immunoblot assay didn't detect AceAa or AceAb products (see Honer et al.%2C1999) but mRNA of AceAa|Rv1915 has been detected (see Betts et al.%2C 2002)%3B so AceAb|Rv1916 could be a pseudogene. Icl2 has 2-methyl-isocitrate lyase (MCL) activity in M. tuberculosis Erdman (See Munoz-Elias et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aceAa;inference=protein motif:PROSITE:PS00161;locus_tag=Rv1915;product=Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl);protein_id=CCP44682.1;transl_table=11
AL123456.3	EMBL	gene	2161566	2162762	.	+	.	ID=gene-Rv1916;Name=aceAb;gbkey=Gene;gene=aceAb;gene_biotype=protein_coding;gene_synonym=icl2b;locus_tag=Rv1916
AL123456.3	EMBL	CDS	2161566	2162762	.	+	0	ID=cds-CCP44683.1;Parent=gene-Rv1916;Dbxref=EnsemblGenomes-Gn:Rv1916,EnsemblGenomes-Tr:CCP44683,GOA:O07717,InterPro:IPR006254,InterPro:IPR015813,UniProtKB/TrEMBL:O07717,NCBI_GP:CCP44683.1;Name=CCP44683.1;Note=Rv1916%2C (MTCY180.02c)%2C len: 398 aa. Probable aceAb%2Cisocitrate lyase (see citations below). Highly similar to the C-terminus of ACEA_MYCLE|P46831 isocitrate lyase from Mycobacterium leprae (606 aa)%2C FASTA results: opt: 1635%2CE(): 0%2C (86.3%25 identity in 278 aa overlap). Although this ORF and the upstream ORF representing the N-terminal half of aceA could be joined by a frameshift no error is apparent in the cosmid%2C or in a seqencing read from the genome of H37Rv. As this ORF has a RBS and transcriptional start immediately following the stop of the upstream ORF%2Cit is possible that they are expressed as two separate modules. In Mycobacterium tuberculosis strain CDC1551%2C aceA exists as a single gene%2C MT1966: the corresponding protein has been purified experimentally and seems have an active isocitrate lyase activity (see Honer et al.%2C 1999). For Mycobacterium tuberculosis strain H37Rv%2C immunoblot assay didn't detect AceAa or AceAb products (see Honer et al.%2C1999) but mRNA of AceAa|Rv1915 has been detected (see Betts et al.%2C 2002)%3B so AceAb|Rv1916 could be a pseudogene. Icl2 has 2-methyl-isocitrate lyase (MCL) activity in M. tuberculosis Erdman (See Munoz-Elias et al.%2C 2006).;gbkey=CDS;gene=aceAb;locus_tag=Rv1916;product=Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl);protein_id=CCP44683.1;transl_table=11
AL123456.3	EMBL	gene	2162932	2167311	.	-	.	ID=gene-Rv1917c;Name=PPE34;gbkey=Gene;gene=PPE34;gene_biotype=protein_coding;locus_tag=Rv1917c
AL123456.3	EMBL	CDS	2162932	2167311	.	-	0	ID=cds-CCP44684.1;Parent=gene-Rv1917c;Dbxref=EnsemblGenomes-Gn:Rv1917c,EnsemblGenomes-Tr:CCP44684,GOA:Q79FI9,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:Q79FI9,NCBI_GP:CCP44684.1;Name=CCP44684.1;Note=Rv1917c%2C (MTV050.01c-MTCY180.01)%2C len: 1459 aa. PPE34%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C MPTR subfamily (see citation below). Similar to MTCY28.16%2C MTCY13E10.17%2C MTCY63.10%2CMTV004.05%2C MTCY98.24%2C MTCY6G11.05%2C etc. C-terminus is identical to Q50471. Unknown Mycobacterium tuberculosis protein (693 aa)%2C FASTA results: opt: 2635%2C E(): 0%2C (99.7%25 identity in 391 aa overlap). Start changed since original submission (+23 aa). Thougth to be surface exposed%2Ccell-wall associated.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE34;inference=protein motif:PROSITE:PS00879;locus_tag=Rv1917c;product=PPE family protein PPE34;protein_id=CCP44684.1;transl_table=11
AL123456.3	EMBL	repeat_region	2163323	2163392	.	-	.	ID=id-Rv1917c;Note=69 bp imperfect direct repeat 3%2C TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCC CGGCTTCACCAT;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	repeat_region	2163393	2163461	.	-	.	ID=id-Rv1917c-2;Note=69 bp imperfect direct repeat 2%2C TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCC TGGTTTCGCGA;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	repeat_region	2163462	2163530	.	-	.	ID=id-Rv1917c-3;Note=69 bp imperfect direct repeat 1%2C TTAATCCGTTCGGTTTGAATATTCCGCTGAGCGGTGCTACCAACGCTGTCACGATCCC TGGTTTCGCGA;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	repeat_region	2163741	2163809	.	-	.	ID=id-Rv1917c-4;Note=69 bp imperfect direct repeat 5%2C TCGGTCCGATTGTGGTGCCTGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	repeat_region	2163810	2163878	.	-	.	ID=id-Rv1917c-5;Note=69 bp imperfect direct repeat 4%2C TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	repeat_region	2163879	2163947	.	-	.	ID=id-Rv1917c-6;Note=69 bp imperfect direct repeat 3%2C TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	repeat_region	2163948	2164016	.	-	.	ID=id-Rv1917c-7;Note=69 bp imperfect direct repeat 2%2C TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	repeat_region	2164017	2164085	.	-	.	ID=id-Rv1917c-8;Note=69 bp imperfect direct repeat 1%2C TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC GCTGGGTGGTG;gbkey=repeat_region;gene=PPE34;locus_tag=Rv1917c
AL123456.3	EMBL	gene	2167649	2170612	.	-	.	ID=gene-Rv1918c;Name=PPE35;gbkey=Gene;gene=PPE35;gene_biotype=protein_coding;locus_tag=Rv1918c
AL123456.3	EMBL	CDS	2167649	2170612	.	-	0	ID=cds-CCP44685.1;Parent=gene-Rv1918c;Dbxref=EnsemblGenomes-Gn:Rv1918c,EnsemblGenomes-Tr:CCP44685,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:Q79FI8,NCBI_GP:CCP44685.1;Name=CCP44685.1;Note=Rv1918c%2C (MTV050.02c)%2C len: 987 aa. PPE35%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 Mycobacterium tuberculosis cosmid (1053 aa)%2C FASTA scores: opt: 3404%2CE(): 0%2C (65.6%25 identity in 1058 aa overlap). Also similar to MTV004.05%2C MTY13E10.17%2C MTV014.03%2C MTCY3C7.23%2CMTCY6G11.05%2C MTCY48.17%2C MTV004.03%2C MTCY31.07%2C MTCY4C12.36%2CMTCY180.01%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE35;locus_tag=Rv1918c;product=PPE family protein PPE35;protein_id=CCP44685.1;transl_table=11
AL123456.3	EMBL	gene	2171061	2171525	.	-	.	ID=gene-Rv1919c;Name=Rv1919c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1919c
AL123456.3	EMBL	CDS	2171061	2171525	.	-	0	ID=cds-CCP44686.1;Parent=gene-Rv1919c;Dbxref=EnsemblGenomes-Gn:Rv1919c,EnsemblGenomes-Tr:CCP44686,GOA:O53961,InterPro:IPR019587,InterPro:IPR023393,UniProtKB/TrEMBL:O53961,NCBI_GP:CCP44686.1;Name=CCP44686.1;Note=Rv1919c%2C (MTV050.03c)%2C len: 154 aa. Conserved protein%2C shows weak similarity to several major pollen antigens e.g. Z72431|BVGC25_1 major allergen bet V 1 from Betula verrucosa (160 aa)%2C FASTA scores: opt: 133%2C E(): 0.012%2C (26.8%25 identity in 149 aa overlap). Also shows some similarity to Rv2574|MTCY227.27C Hypothetical protein from Mycobacterium tuberculosis (167 aa)%2C (27.4%25 identity in 124 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1919c;product=Conserved protein;protein_id=CCP44686.1;transl_table=11
AL123456.3	EMBL	gene	2171623	2172486	.	+	.	ID=gene-Rv1920;Name=Rv1920;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1920
AL123456.3	EMBL	CDS	2171623	2172486	.	+	0	ID=cds-CCP44687.1;Parent=gene-Rv1920;Dbxref=EnsemblGenomes-Gn:Rv1920,EnsemblGenomes-Tr:CCP44687,GOA:O53962,InterPro:IPR002123,InterPro:IPR016676,UniProtKB/TrEMBL:O53962,NCBI_GP:CCP44687.1;Name=CCP44687.1;Note=Rv1920%2C (MTV050.04)%2C len: 287 aa. Probable membrane protein%2C similar to AL0215|SC10A5.04 putative membrane protein from Streptomyces coelicolor cosmid 10A5 (295 aa)%2CFASTA scores: opt: 292%2C E(): 3.6e-13%2C (31.3%25 identity in 243 aa overlap). Also weakly similar to several Mycobacterial putative proteins with unknown function e.g. Rv0502%2C Rv1428c%2C U00018_22 Mycobacterium leprae cosmid B2168.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1920;product=Probable membrane protein;protein_id=CCP44687.1;transl_table=11
AL123456.3	EMBL	gene	2172524	2173795	.	-	.	ID=gene-Rv1921c;Name=lppF;gbkey=Gene;gene=lppF;gene_biotype=protein_coding;locus_tag=Rv1921c
AL123456.3	EMBL	CDS	2172524	2173795	.	-	0	ID=cds-CCP44688.1;Parent=gene-Rv1921c;Dbxref=EnsemblGenomes-Gn:Rv1921c,EnsemblGenomes-Tr:CCP44688,InterPro:IPR023214,UniProtKB/TrEMBL:O53963,NCBI_GP:CCP44688.1;Name=CCP44688.1;Note=Rv1921c%2C (MTCY09F9.43-MTV050.05c)%2C len: 423 aa. Probable lppF%2C conserved lipoprotein%2C similar to G403173 lipoprotein precursor (fragment) from Rhodococcus erythropolis (225 aa)%2C fasta scores: opt: 364%2C E(): 9.2e-19%2C (41.9%25 identity in 148 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lppF;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1921c;product=Probable conserved lipoprotein LppF;protein_id=CCP44688.1;transl_table=11
AL123456.3	EMBL	gene	2174067	2175182	.	+	.	ID=gene-Rv1922;Name=Rv1922;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1922
AL123456.3	EMBL	CDS	2174067	2175182	.	+	0	ID=cds-CCP44689.1;Parent=gene-Rv1922;Dbxref=EnsemblGenomes-Gn:Rv1922,EnsemblGenomes-Tr:CCP44689,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:P95291,NCBI_GP:CCP44689.1;Name=CCP44689.1;Note=Rv1922%2C (MTCY09F9.42c)%2C len: 371 aa. Probable conserved lipoprotein%2C possibly peptidase similar to many peptidases%2C e.g. P15555|DAC_STRSQ D-alanyl-D-alanine carboxypeptidase from Streptomyces sp. (406 aa)%2C FASTA scores: opt: 382%2C E(): 3.1e-17%2C (28.0%25 identity in 379 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497%2C Rv2463%2C Rv3775%2C etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1922;product=Probable conserved lipoprotein;protein_id=CCP44689.1;transl_table=11
AL123456.3	EMBL	gene	2175173	2176513	.	+	.	ID=gene-Rv1923;Name=lipD;gbkey=Gene;gene=lipD;gene_biotype=protein_coding;locus_tag=Rv1923
AL123456.3	EMBL	CDS	2175173	2176513	.	+	0	ID=cds-CCP44690.1;Parent=gene-Rv1923;Dbxref=EnsemblGenomes-Gn:Rv1923,EnsemblGenomes-Tr:CCP44690,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:P95290,NCBI_GP:CCP44690.1;Name=CCP44690.1;Note=Rv1923%2C (MTCY09F9.41c)%2C len: 446 aa. Probable lipD%2Chydrolase lipase%2C similar to esterases and beta-lactamases e.g. G151214 esterase%2C (389 aa)%2C fasta scores: opt: 569%2CE(): 5.4e-29%2C (33.7%25 identity in 401 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv1497%2C Rv2463%2C Rv3775%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipD;locus_tag=Rv1923;product=Probable lipase LipD;protein_id=CCP44690.1;transl_table=11
AL123456.3	EMBL	gene	2176550	2176930	.	-	.	ID=gene-Rv1924c;Name=Rv1924c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1924c
AL123456.3	EMBL	CDS	2176550	2176930	.	-	0	ID=cds-CCP44691.1;Parent=gene-Rv1924c;Dbxref=EnsemblGenomes-Gn:Rv1924c,EnsemblGenomes-Tr:CCP44691,GOA:P95289,UniProtKB/TrEMBL:P95289,NCBI_GP:CCP44691.1;Name=CCP44691.1;Note=Rv1924c%2C (MTCY09F9.40)%2C len: 126 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1924c;product=Unknown protein;protein_id=CCP44691.1;transl_table=11
AL123456.3	EMBL	gene	2177087	2178949	.	+	.	ID=gene-Rv1925;Name=fadD31;gbkey=Gene;gene=fadD31;gene_biotype=protein_coding;locus_tag=Rv1925
AL123456.3	EMBL	CDS	2177087	2178949	.	+	0	ID=cds-CCP44692.1;Parent=gene-Rv1925;Dbxref=EnsemblGenomes-Gn:Rv1925,EnsemblGenomes-Tr:CCP44692,GOA:I6Y7V6,InterPro:IPR000873,UniProtKB/TrEMBL:I6Y7V6,NCBI_GP:CCP44692.1;Name=CCP44692.1;Note=Rv1925%2C (MTCY09F9.39c)%2C len: 620 aa. Probable fadD31%2C acyl-CoA synthetase%2C highly similar to others from Mycobacterium leprae e.g. NP_301198.1|NC_002677 putative acyl-CoA synthetase (635 aa)%3B NP_302537.1|NC_002677 probable acyl-CoA synthase (583 aa)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD32 (637 aa)%3B fadD21 (578 aa)%3B fadD29 (619 aa)%3B fadD26|FD26_MYCTU|Q10976 (626 aa)%2C FASTA scores: opt: 945%2CE(): 0%2C (39.8%25 identity in 598 aa overlap)%3B etc. Also similar to N-terminus of G1171128 saframycin MX1 synthetase B from Myxococcus xanthus (1770 aa)%2C FASTA scores: opt: 845%2C E(): 0%2C (37.4%25 identity in 593 aa overlap)%3B N-terminus of T34918 polyketide synthase from Streptomyces coelicolor (2297 aa)%3B etc. Nucleotide position 2177654 in the genome sequence has been corrected%2C A:C resulting in M190L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD31;locus_tag=Rv1925;product=Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase);protein_id=CCP44692.1;transl_table=11
AL123456.3	EMBL	gene	2178957	2179436	.	-	.	ID=gene-Rv1926c;Name=mpt63;gbkey=Gene;gene=mpt63;gene_biotype=protein_coding;gene_synonym=mpb63;locus_tag=Rv1926c
AL123456.3	EMBL	CDS	2178957	2179436	.	-	0	ID=cds-CCP44693.1;Parent=gene-Rv1926c;Dbxref=EnsemblGenomes-Gn:Rv1926c,EnsemblGenomes-Tr:CCP44693,GOA:P9WIP1,InterPro:IPR015250,InterPro:IPR029050,PDB:1LMI,NCBI_GP:CCP44693.1;Name=CCP44693.1;Note=Rv1926c%2C (MT1977%2C MTCY09F9.38)%2C len: 159 aa. Mpt63 (alternate gene name: mpb63)%2C immunogenic protein (see citations below)%2C identical to MPT63|MPB63 from Mycobacterium bovis (159 aa). Exported protein containing a N-terminal signal sequence: see notes below about proteomics. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mpt63;locus_tag=Rv1926c;product=Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein);protein_id=CCP44693.1;transl_table=11
AL123456.3	EMBL	gene	2179673	2180446	.	+	.	ID=gene-Rv1927;Name=Rv1927;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1927
AL123456.3	EMBL	CDS	2179673	2180446	.	+	0	ID=cds-CCP44694.1;Parent=gene-Rv1927;Dbxref=EnsemblGenomes-Gn:Rv1927,EnsemblGenomes-Tr:CCP44694,InterPro:IPR018644,UniProtKB/TrEMBL:P95287,NCBI_GP:CCP44694.1;Name=CCP44694.1;Note=Rv1927%2C (MTCY09F9.37c)%2C len: 257 aa. Conserved hypothetical protein%2C similar to SCG11A.10c|AL133210 hypothetical protein from Streptomyces coelicolor (252 aa)%2CFASTA scores: opt: 729%2C E(): 0%2C (48.3%25 identity in 238 aa overlap). Slight similarity with P54543|YQJF_BACSU hypothetical 23.9 kDa protein from Bacillus subtilis (209 aa)%2C FASTA scores%2C opt: 230%2C E(): 2.8e-08%2C (28.0%25 identity in 164 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1927;product=Conserved hypothetical protein;protein_id=CCP44694.1;transl_table=11
AL123456.3	EMBL	gene	2180450	2181217	.	-	.	ID=gene-Rv1928c;Name=Rv1928c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1928c
AL123456.3	EMBL	CDS	2180450	2181217	.	-	0	ID=cds-CCP44695.1;Parent=gene-Rv1928c;Dbxref=EnsemblGenomes-Gn:Rv1928c,EnsemblGenomes-Tr:CCP44695,GOA:P95286,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:P95286,NCBI_GP:CCP44695.1;Name=CCP44695.1;Note=Rv1928c%2C (MTCY09F9.36)%2C len: 255 aa. Probable short-chain dehydrogenase/reductase%2C highly similar to others e.g. NP_228109.1|NC_000853 oxidoreductase (short chain dehydrogenase/reductase family) from Thermotoga maritima (257 aa)%3B T41116 short chain dehydrogenase from Schizosaccharomyces pombe (261 aa)%3B P87219|SOU1_CANAL sorbitol utilization protein (SDR family) from Candida albicans (281 aa)%3B P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase from Escherichia coli (255 aa)%2C FASTA scores: opt: 541%2C E(): 1.2e-27%2C (37.5%25 identity in 251 aa overlap)%3B etc. Also similar to many mycobacterial tuberculosis proteins e.g. Rv1350%2C Rv0927c%2C Rv2002%2C Rv0769%2C Rv2766c%2Cetc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1928c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP44695.1;transl_table=11
AL123456.3	EMBL	gene	2181262	2181906	.	-	.	ID=gene-Rv1929c;Name=Rv1929c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1929c
AL123456.3	EMBL	CDS	2181262	2181906	.	-	0	ID=cds-CCP44696.1;Parent=gene-Rv1929c;Dbxref=EnsemblGenomes-Gn:Rv1929c,EnsemblGenomes-Tr:CCP44696,InterPro:IPR017517,InterPro:IPR017519,UniProtKB/TrEMBL:P95285,NCBI_GP:CCP44696.1;Name=CCP44696.1;Note=Rv1929c%2C MTCY09F9.35%2C len: 214 aa. Conserved hypothetical protein%2C similar to SC4G6.14|AL096884 hypothetical protein from Streptomyces coelicolor (211 aa)%2CFASTA scores: opt: 416%2C E(): 2.4e-22%2C (39.8%25 identity in 206 aa overlap).;gbkey=CDS;locus_tag=Rv1929c;product=Conserved hypothetical protein;protein_id=CCP44696.1;transl_table=11
AL123456.3	EMBL	gene	2181918	2182442	.	-	.	ID=gene-Rv1930c;Name=Rv1930c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1930c
AL123456.3	EMBL	CDS	2181918	2182442	.	-	0	ID=cds-CCP44697.1;Parent=gene-Rv1930c;Dbxref=EnsemblGenomes-Gn:Rv1930c,EnsemblGenomes-Tr:CCP44697,InterPro:IPR025628,InterPro:IPR029062,UniProtKB/TrEMBL:P95284,NCBI_GP:CCP44697.1;Name=CCP44697.1;Note=Rv1930c%2C MTCY09F9.34%2C len: 174 aa. Conserved hypothetical protein%2C similar to SC5F2A.30|AL049587 hypothetical protein from Streptomyces coelicolor (211 aa)%2CFASTA scores: opt: 307%2C E(): 2.8e-13%2C (54.8%25 identity in 84 aa overlap). Some similarity to M. tuber culosis hypothetical protein Rv0052|MTCY21D4.15 (43%25 identity in 93 aa overlap).;gbkey=CDS;locus_tag=Rv1930c;product=Conserved hypothetical protein;protein_id=CCP44697.1;transl_table=11
AL123456.3	EMBL	gene	2182460	2183239	.	-	.	ID=gene-Rv1931c;Name=Rv1931c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1931c
AL123456.3	EMBL	CDS	2182460	2183239	.	-	0	ID=cds-CCP44698.1;Parent=gene-Rv1931c;Dbxref=EnsemblGenomes-Gn:Rv1931c,EnsemblGenomes-Tr:CCP44698,GOA:P95283,InterPro:IPR009057,InterPro:IPR018060,InterPro:IPR025628,InterPro:IPR029062,UniProtKB/TrEMBL:P95283,NCBI_GP:CCP44698.1;Name=CCP44698.1;Note=Rv1931c%2C (MTCY09F9.33)%2C len: 259 aa. Probable transcriptional regulatory protein. Similarity in C-terminal half to transcriptional activators e.g. Q43970 AraC-like protein (227 aa)%2C FASTA scores: opt: 238%2C E(): 7.1e-07%2C (42.4%25 identity in 92 aa overlap). Similar to many probable transcription regulators in Streptomyces e.g. AL049587|SC5F2A.29 Streptomyces coelicolor (325 aa)%2C FASTA scores: opt: 387%2C E(): 3.2e-16%2C (34.4%25 identity in 259 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1931c;product=Probable transcriptional regulatory protein;protein_id=CCP44698.1;transl_table=11
AL123456.3	EMBL	gene	2183372	2183869	.	+	.	ID=gene-Rv1932;Name=tpx;gbkey=Gene;gene=tpx;gene_biotype=protein_coding;gene_synonym=cfp20;locus_tag=Rv1932
AL123456.3	EMBL	CDS	2183372	2183869	.	+	0	ID=cds-CCP44699.1;Parent=gene-Rv1932;Dbxref=EnsemblGenomes-Gn:Rv1932,EnsemblGenomes-Tr:CCP44699,GOA:P9WG35,InterPro:IPR002065,InterPro:IPR012336,InterPro:IPR013740,InterPro:IPR018219,PDB:1XVQ,PDB:1Y25,NCBI_GP:CCP44699.1;Name=CCP44699.1;Note=Rv1932%2C (MTCY09F9.32c)%2C len: 165 aa. Probable tpx (alternate gene name: cfp20)%2C thiol peroxidase similar to TPX_ECOLI|P37901 thiol peroxidase (p20) from Escherichia coli (167 aa)%2C fasta scores: opt: 535%2C E(): 7.3e-25%2C (52.4%25 identity in 164 aa overlap). There are four other related enzymes in M. tuberculosis: Rv2428%2C Rv2521%2C Rv2238c%2CRv1608c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tpx;locus_tag=Rv1932;product=Probable thiol peroxidase Tpx;protein_id=CCP44699.1;transl_table=11
AL123456.3	EMBL	gene	2183866	2184957	.	-	.	ID=gene-Rv1933c;Name=fadE18;gbkey=Gene;gene=fadE18;gene_biotype=protein_coding;locus_tag=Rv1933c
AL123456.3	EMBL	CDS	2183866	2184957	.	-	0	ID=cds-CCP44700.1;Parent=gene-Rv1933c;Dbxref=EnsemblGenomes-Gn:Rv1933c,EnsemblGenomes-Tr:CCP44700,GOA:P95281,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P95281,NCBI_GP:CCP44700.1;Name=CCP44700.1;Note=Rv1933c%2C (MTCY09F9.31)%2C len: 363 aa. Probable fadE18%2C acyl-CoA dehydrogenase%2C similar to many e.g. CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (362 aa)%3B NP_421282.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (344 aa)%3B ACDS_RAT|P15651 short-chain specific acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 aa)%2C fasta scores: opt: 239%2C E(): 2.1e-08%2C (28.4%25 identity in 331 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. N-terminus of fadE22 (721 aa)%3B fadE33 (318 aa)%3B N-terminus of fadE34 (711 aa)%3B etc. Could belong to the acyl-CoA dehydrogenases family.;gbkey=CDS;gene=fadE18;locus_tag=Rv1933c;product=Probable acyl-CoA dehydrogenase FadE18;protein_id=CCP44700.1;transl_table=11
AL123456.3	EMBL	gene	2184959	2186188	.	-	.	ID=gene-Rv1934c;Name=fadE17;gbkey=Gene;gene=fadE17;gene_biotype=protein_coding;locus_tag=Rv1934c
AL123456.3	EMBL	CDS	2184959	2186188	.	-	0	ID=cds-CCP44701.1;Parent=gene-Rv1934c;Dbxref=EnsemblGenomes-Gn:Rv1934c,EnsemblGenomes-Tr:CCP44701,GOA:P95280,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P95280,NCBI_GP:CCP44701.1;Name=CCP44701.1;Note=Rv1934c%2C (MTCY09F9.30)%2C len: 409 aa. Probable fadE17%2C acyl-CoA dehydrogenase%2C highly similar to ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium leprae (389 aa)%2C FASTA scores: opt: 414%2C E(): 2.6e-19%2C(28.3%25 identity in 407 aa overlap). Also similar to many e.g. NP_249713.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (381 aa)%3B NP_420614.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (355 aa)%3B CAB61610.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (393 aa)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE30 (385 aa)%3B fadE31 (377 aa)%3B C-terminus of fadE34 (711 aa)%3B etc. Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE17;locus_tag=Rv1934c;product=Probable acyl-CoA dehydrogenase FadE17;protein_id=CCP44701.1;transl_table=11
AL123456.3	EMBL	gene	2186203	2187159	.	-	.	ID=gene-Rv1935c;Name=echA13;gbkey=Gene;gene=echA13;gene_biotype=protein_coding;locus_tag=Rv1935c
AL123456.3	EMBL	CDS	2186203	2187159	.	-	0	ID=cds-CCP44702.1;Parent=gene-Rv1935c;Dbxref=EnsemblGenomes-Gn:Rv1935c,EnsemblGenomes-Tr:CCP44702,GOA:P95279,InterPro:IPR001753,InterPro:IPR029045,UniProtKB/TrEMBL:P95279,NCBI_GP:CCP44702.1;Name=CCP44702.1;Note=Rv1935c%2C (MTCY09F9.29)%2C len: 318 aa. Possible echA13%2C enoyl-CoA hydratase%2C similar to others and various enzymes e.g. CAC48381.1|Y16952 putative enoyl-CoA-isomerase from Amycolatopsis mediterranei (269 aa)%3B AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa)%3B AAF78820.1|AF042490 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. TM1 (276 aa)%3B ECHM_RAT|P14604 enoyl-CoA hydratase mitochondrial precursor from Rattus norvegicus (Rat) (290 aa)%2C FASTA scores: opt: 228%2C E(): 1.2e-08%2C (31.0%25 identity in 258 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA13;locus_tag=Rv1935c;product=Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP44702.1;transl_table=11
AL123456.3	EMBL	gene	2187384	2188493	.	+	.	ID=gene-Rv1936;Name=Rv1936;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1936
AL123456.3	EMBL	CDS	2187384	2188493	.	+	0	ID=cds-CCP44703.1;Parent=gene-Rv1936;Dbxref=EnsemblGenomes-Gn:Rv1936,EnsemblGenomes-Tr:CCP44703,GOA:P95278,InterPro:IPR011251,UniProtKB/TrEMBL:P95278,NCBI_GP:CCP44703.1;Name=CCP44703.1;Note=Rv1936%2C (MTCY09F9.28c)%2C len: 369 aa. Possible monooxygenase%2C similar to LXA2_PHOLU|P23146 alkanal monooxygenase alpha chain (362 aa)%2C FASTA scores: opt: 196%2CE(): 6.3e-06%2C (22.3%25 identity in 373 aa overlap). Also similar to many other Mycobacterium tuberculosis hypothetical oxidoreductases and monooxygenases e.g. Rv0953c%2C Rv0791c%2C Rv0132c%2C etc.;gbkey=CDS;locus_tag=Rv1936;product=Possible monooxygenase;protein_id=CCP44703.1;transl_table=11
AL123456.3	EMBL	gene	2188496	2191015	.	+	.	ID=gene-Rv1937;Name=Rv1937;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1937
AL123456.3	EMBL	CDS	2188496	2191015	.	+	0	ID=cds-CCP44704.1;Parent=gene-Rv1937;Dbxref=EnsemblGenomes-Gn:Rv1937,EnsemblGenomes-Tr:CCP44704,GOA:P95277,InterPro:IPR001041,InterPro:IPR001221,InterPro:IPR001433,InterPro:IPR006058,InterPro:IPR008333,InterPro:IPR012675,InterPro:IPR017927,InterPro:IPR017938,UniProtKB/TrEMBL:P95277,NCBI_GP:CCP44704.1;Name=CCP44704.1;Note=Rv1937%2C (MTCY09F9.27c)%2C len: 839 aa. Possible oxygenase%2C similar in N-terminus to N-terminal part (approx. 350 aa) of dioxygenases (including ring-hydroxylating dioxygenase electron transfer components) and monooxygenases%2C e.g. AAC34815.1|AF071556 anthranilate dioxygenase reductase from Acinetobacter sp. (343 aa)%3B AAK52291.1|AY026914|AntC putative anthranilate dioxygenase reductase from Pseudomonas putida (340 aa)%3B AAF63450.1|AF218267_7|AF218267 benzoate dioxygenase / ferredoxin reductase from Pseudomonas putida (336 aa)%3B P23101|XYLZ_PSEPU toluate 1%2C2-dioxygenase electron transfer component [includes: ferredoxin%3B ferredoxin--NAD(+) reductase ] from Pseudomonas putida plasmid TOL pWW0 (336 aa)%2C FASTA scores: opt: 700%2C E(): 0%2C (34.3%25 identity in 335 aa overlap)%3B S23479 probable benzoate 1%2C2-dioxygenase reductase component benC from Acinetobacter calcoaceticus (338 aa)%3B AAC45294.1|U81594 soluble methane monooxygenase protein C from Methylocystis sp. (343 aa)%3B P22868|MEMC_METCA methane monooxygenase component C from Methylococcus capsulatus (348 aa)%3B etc. Also similar in part to Mycobacterium tuberculosis hypothetical electron transfer proteins Rv3554%2C Rv3571%2C etc. Contains PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00197;locus_tag=Rv1937;product=Possible oxygenase;protein_id=CCP44704.1;transl_table=11
AL123456.3	EMBL	gene	2191027	2192097	.	+	.	ID=gene-Rv1938;Name=ephB;gbkey=Gene;gene=ephB;gene_biotype=protein_coding;locus_tag=Rv1938
AL123456.3	EMBL	CDS	2191027	2192097	.	+	0	ID=cds-CCP44705.1;Parent=gene-Rv1938;Dbxref=EnsemblGenomes-Gn:Rv1938,EnsemblGenomes-Tr:CCP44705,GOA:I6YC03,InterPro:IPR000073,InterPro:IPR000639,InterPro:IPR029058,UniProtKB/TrEMBL:I6YC03,NCBI_GP:CCP44705.1;Name=CCP44705.1;Note=Rv1938%2C (MTCY09F9.26c)%2C len: 356 aa. Probable ephB%2Cepoxide hydrolase (see citation below)%2C similar to many e.g. G1109600 ATSEH (321 aa)%2C FASTA scores: opt: 442%2C E(): 1.2e-21 (33.1%25 identity in 356 aa overlap)%3B etc. Also similar to many other M. tuberculosis hypothetical epoxide hydrolases e.g. Rv3617%2C Rv3670%2C Rv0134%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ephB;locus_tag=Rv1938;product=Probable epoxide hydrolase EphB (epoxide hydratase);protein_id=CCP44705.1;transl_table=11
AL123456.3	EMBL	gene	2192094	2192609	.	+	.	ID=gene-Rv1939;Name=Rv1939;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1939
AL123456.3	EMBL	CDS	2192094	2192609	.	+	0	ID=cds-CCP44706.1;Parent=gene-Rv1939;Dbxref=EnsemblGenomes-Gn:Rv1939,EnsemblGenomes-Tr:CCP44706,GOA:P95275,InterPro:IPR002563,InterPro:IPR012349,UniProtKB/TrEMBL:P95275,NCBI_GP:CCP44706.1;Name=CCP44706.1;Note=Rv1939%2C (MTCY09F9.25c)%2C len: 171 aa. Probable oxidoreductase%2C similar to NP_302637.1|NC_002677 probable oxidoreductase from Mycobacterium leprae (162 aa) Also similar to NTAB_CHELE|P54990 nitrilotriacetate monooxygenase component from Chelatobacter heintzii (322 aa)%2C fasta scores: opt: 269%2C E(): 5.3e-11%2C (33.1%25 identity in 151 aa overlap). And similar to Mycobacterium tuberculosis probable monooxygenase components Rv0246%2CRv3567%2C and to a lesser extent%2C Rv3007c.;gbkey=CDS;locus_tag=Rv1939;product=Probable oxidoreductase;protein_id=CCP44706.1;transl_table=11
AL123456.3	EMBL	gene	2192606	2193667	.	+	.	ID=gene-Rv1940;Name=ribA1;gbkey=Gene;gene=ribA1;gene_biotype=protein_coding;gene_synonym=ribA;locus_tag=Rv1940
AL123456.3	EMBL	CDS	2192606	2193667	.	+	0	ID=cds-CCP44707.1;Parent=gene-Rv1940;Dbxref=EnsemblGenomes-Gn:Rv1940,EnsemblGenomes-Tr:CCP44707,GOA:L7N669,InterPro:IPR000422,InterPro:IPR000926,InterPro:IPR016299,InterPro:IPR017945,UniProtKB/TrEMBL:L7N669,NCBI_GP:CCP44707.1;Name=CCP44707.1;Note=Rv1940%2C (MTCY09F9.24c)%2C len: 353 aa. Probable ribA1%2CRiboflavin biosynthesis protein%2C similar to GCH2_BACSU|P17620 gtp cyclohydrolase II (398 aa)%2C FASTA scores: opt: 682%2C E(): 0%2C (37.7%25 identity in 363 aa overlap)%2C also similar to Rv1415|MTCY21B4.33|ribA2 (428 aa) (45.4%25 identity in 368 aa overlap). Note that previously known as ribA.;gbkey=CDS;gene=ribA1;locus_tag=Rv1940;product=Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II);protein_id=CCP44707.1;transl_table=11
AL123456.3	EMBL	gene	2193664	2194434	.	+	.	ID=gene-Rv1941;Name=Rv1941;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1941
AL123456.3	EMBL	CDS	2193664	2194434	.	+	0	ID=cds-CCP44708.1;Parent=gene-Rv1941;Dbxref=EnsemblGenomes-Gn:Rv1941,EnsemblGenomes-Tr:CCP44708,GOA:I6XZC4,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:I6XZC4,NCBI_GP:CCP44708.1;Name=CCP44708.1;Note=Rv1941%2C (MTCY09F9.23c)%2C len: 256 aa. Probable short-chain dehydrogenase/reductase%2C similar to various dehydrogenases/reductases%2C generally belonging to SDR family%2C e.g. NP_299015.1|NC_002488 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-diol dehydrogenase from Xylella fastidiosa (255 aa)%3B NP_250340.1|NC_002516 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa)%3B NP_106890.1|NC_002678 probable short-chain type dehydrogenase/reductase from Mesorhizobium loti (374 aa) (has its N-terminus longter)%3B P50197|LINC_PSEPA 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-dehydrogenase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (250 aa)%2C FASTA scores: opt: 529%2C E(): 5.7e-25%2C (40.6%25 identity in 251 aa overlap)%3B etc. Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv1941;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP44708.1;transl_table=11
AL123456.3	EMBL	gene	2194644	2194973	.	-	.	ID=gene-Rv1942c;Name=mazF5;gbkey=Gene;gene=mazF5;gene_biotype=protein_coding;gene_synonym=mt5;locus_tag=Rv1942c
AL123456.3	EMBL	CDS	2194644	2194973	.	-	0	ID=cds-CCP44709.1;Parent=gene-Rv1942c;Dbxref=EnsemblGenomes-Gn:Rv1942c,EnsemblGenomes-Tr:CCP44709,GOA:P95272,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP44709.1;Name=CCP44709.1;Note=Rv1942c%2C (MTCY09F9.22)%2C len: 109 aa. Possible mazF5%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1943c (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%2C shows some similarity to Q10867|MTCY39.28|Rv1991 hypothetical 12.3 kDa protein (114 aa)%2C FASTA scores: opt: 117%2C E(): 0.021%2C (24. 5%25 identity in 110 aa overlap) also P33645|CHPA_ECOLI pemk-like protein 1 (mazf protein) from Escherichia coli (111 aa)%2C FASTA scores: opt: 104%2C E(): 0.18%2C (29.1%25 identity in 110 aa overlap). Also similar to Mycobacterium tuberculosis Rv0659c (102 aa) (32.7%25 identity in 101 aa overlap)%3B Rv1102c (33.3%25 identity in 93 aa overlap) and Rv1495.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mazF5;locus_tag=Rv1942c;product=Possible toxin MazF5;protein_id=CCP44709.1;transl_table=11
AL123456.3	EMBL	gene	2194970	2195347	.	-	.	ID=gene-Rv1943c;Name=mazE5;gbkey=Gene;gene=mazE5;gene_biotype=protein_coding;locus_tag=Rv1943c
AL123456.3	EMBL	CDS	2194970	2195347	.	-	0	ID=cds-CCP44710.1;Parent=gene-Rv1943c;Dbxref=EnsemblGenomes-Gn:Rv1943c,EnsemblGenomes-Tr:CCP44710,GOA:P9WJ89,NCBI_GP:CCP44710.1;Name=CCP44710.1;Note=Rv1943c%2C (MTCY09F9.21)%2C len: 125 aa. Possible mazE5%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1942c (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%2C shows some similarity with Rv1946c|MTCY09F9.18|lppG possible conserved lipoprotein from Mycobacterium tuberculosis (150 aa)%2C FASTA score: (71.4%25 identity in 28 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mazE5;locus_tag=Rv1943c;product=Possible antitoxin MazE5;protein_id=CCP44710.1;transl_table=11
AL123456.3	EMBL	gene	2195344	2195934	.	-	.	ID=gene-Rv1944c;Name=Rv1944c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1944c
AL123456.3	EMBL	CDS	2195344	2195934	.	-	0	ID=cds-CCP44711.1;Parent=gene-Rv1944c;Dbxref=EnsemblGenomes-Gn:Rv1944c,EnsemblGenomes-Tr:CCP44711,InterPro:IPR004027,UniProtKB/TrEMBL:P95270,NCBI_GP:CCP44711.1;Name=CCP44711.1;Note=Rv1944c%2C (MTCY09F9.20)%2C len: 196 aa. Conserved protein%2C similar to C-terminal part of SCE20.29|AL136058|CAB65585.1 hypothetical protein from Streptomyces coelicolor (338 aa)%2C blastp scores%2C Identities %3D 37/131 (28%25)%2C Positives %3D 51/131 (38%25).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1944c;product=Conserved protein;protein_id=CCP44711.1;transl_table=11
AL123456.3	EMBL	gene	2195989	2197353	.	+	.	ID=gene-Rv1945;Name=Rv1945;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1945
AL123456.3	EMBL	CDS	2195989	2197353	.	+	0	ID=cds-CCP44712.1;Parent=gene-Rv1945;Dbxref=EnsemblGenomes-Gn:Rv1945,EnsemblGenomes-Tr:CCP44712,GOA:P9WLQ5,InterPro:IPR002711,InterPro:IPR003615,InterPro:IPR003870,NCBI_GP:CCP44712.1;Name=CCP44712.1;Note=Rv1945%2C (MTCY09F9.19c)%2C len: 454 aa. Member of Mycobacterium tuberculosis REP13E12 repeat family. Similar to several others%2C best with Rv1148c|Z95584|MTCI65.15 (482 aa)%2C FASTA score: opt: 2954%2C E(): 0%2C (97.1%25 identity in 454 aa overlap). Contains possible helix-turn-helix motif at aa 74-95 (+2.90 SD).;gbkey=CDS;locus_tag=Rv1945;product=Conserved hypothetical protein;protein_id=CCP44712.1;transl_table=11
AL123456.3	EMBL	repeat_region	2195989	2197350	.	+	.	ID=id-Rv1945;Note=REP-7%2C len: 1362 nt. REP09F9%2C member of the REP13E12 family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region;locus_tag=Rv1945
AL123456.3	EMBL	gene	2197508	2197960	.	-	.	ID=gene-Rv1946c;Name=lppG;gbkey=Gene;gene=lppG;gene_biotype=protein_coding;locus_tag=Rv1946c
AL123456.3	EMBL	CDS	2197508	2197960	.	-	0	ID=cds-CCP44713.1;Parent=gene-Rv1946c;Dbxref=EnsemblGenomes-Gn:Rv1946c,EnsemblGenomes-Tr:CCP44713,UniProtKB/TrEMBL:P95268,NCBI_GP:CCP44713.1;Name=CCP44713.1;Note=Rv1946c%2C (MTCY09F9.18)%2C len: 150 aa. Possible lppG%2Cconserved lipoprotein%2C showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tuberculosis (125 aa)%2C FASTA score: (71.4%25 identity in 28 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=lppG;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1946c;product=Possible lipoprotein;protein_id=CCP44713.1;transl_table=11
AL123456.3	EMBL	gene	2198024	2198425	.	+	.	ID=gene-Rv1947;Name=Rv1947;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1947
AL123456.3	EMBL	CDS	2198024	2198425	.	+	0	ID=cds-CCP44714.1;Parent=gene-Rv1947;Dbxref=EnsemblGenomes-Gn:Rv1947,EnsemblGenomes-Tr:CCP44714,UniProtKB/TrEMBL:P95267,NCBI_GP:CCP44714.1;Name=CCP44714.1;Note=Rv1947%2C (MTCY09F9.17c)%2C len: 133 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1947;product=Hypothetical protein;protein_id=CCP44714.1;transl_table=11
AL123456.3	EMBL	gene	2198714	2199064	.	-	.	ID=gene-Rv1948c;Name=Rv1948c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1948c
AL123456.3	EMBL	CDS	2198714	2199064	.	-	0	ID=cds-CCP44715.1;Parent=gene-Rv1948c;Dbxref=EnsemblGenomes-Gn:Rv1948c,EnsemblGenomes-Tr:CCP44715,UniProtKB/TrEMBL:P95266,NCBI_GP:CCP44715.1;Name=CCP44715.1;Note=Rv1948c%2C (MTCY09F9.16)%2C len: 116 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv1948c;product=Hypothetical protein;protein_id=CCP44715.1;transl_table=11
AL123456.3	EMBL	gene	2199075	2200034	.	-	.	ID=gene-Rv1949c;Name=Rv1949c;end_range=2200034,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1949c;partial=true
AL123456.3	EMBL	CDS	2199075	2200034	.	-	0	ID=cds-CCP44716.1;Parent=gene-Rv1949c;Dbxref=EnsemblGenomes-Gn:Rv1949c,EnsemblGenomes-Tr:CCP44716,UniProtKB/TrEMBL:L0T9Q6,NCBI_GP:CCP44716.1;Name=CCP44716.1;Note=Rv1949c%2C (MTCY09F9.15)%2C len: 319 aa. Conserved hypothetical protein%2C partial ORF. Rv1949c and Rv1950c|MTCY09F9.14 are similar but frameshifted with respect to Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd protein (323 aa)%2C FASTA scores: opt: 459%2C E(): 2.8e-16%2C(54.8%25 identity in 157 aa overlap). Cosmid sequence appears to be correct%2C genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97. Similar to Mycobacterium tuberculosis hypothetical proteins: Rv2542%2CRv2077c%2C Rv2797c%2C Rv0963c%2C etc.;end_range=2200034,.;gbkey=CDS;locus_tag=Rv1949c;partial=true;product=Conserved hypothetical protein;protein_id=CCP44716.1;transl_table=11
AL123456.3	EMBL	gene	2199998	2200189	.	-	.	ID=gene-Rv1950c;Name=Rv1950c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1950c
AL123456.3	EMBL	CDS	2199998	2200189	.	-	0	ID=cds-CCP44717.1;Parent=gene-Rv1950c;Dbxref=EnsemblGenomes-Gn:Rv1950c,EnsemblGenomes-Tr:CCP44717,UniProtKB/TrEMBL:P95264,NCBI_GP:CCP44717.1;Name=CCP44717.1;Note=Rv1950c%2C (MTCY09F9.14)%2C len: 63 aa. Conserved hypothetical protein%2C partial ORF. Highly similar to N-terminus of Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kDa protein (323 aa)%2C FASTA scores: opt: 280%2C E(): 1.2 e-16%2C (71.7%25 identity in 53 aa overlap) but homology continues in different frame ie MTCY09F9.15%2C cosmid sequence appears to be correct%2C genomic sequence is also frameshifted in Mycobacterium bovis strain AF2122/97.;gbkey=CDS;locus_tag=Rv1950c;product=Conserved hypothetical protein;protein_id=CCP44717.1;transl_table=11
AL123456.3	EMBL	gene	2200190	2200486	.	-	.	ID=gene-Rv1951c;Name=Rv1951c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1951c
AL123456.3	EMBL	CDS	2200190	2200486	.	-	0	ID=cds-CCP44718.1;Parent=gene-Rv1951c;Dbxref=EnsemblGenomes-Gn:Rv1951c,EnsemblGenomes-Tr:CCP44718,UniProtKB/TrEMBL:P95263,NCBI_GP:CCP44718.1;Name=CCP44718.1;Note=Rv1951c%2C (MTCY09F9.13)%2C len: 98 aa. Conserved hypothetical protein%2C similar to Mycobacterium tuberculosis hypothetical protein Rv2541 (135 aa) (40.9%25 identity in 88 aa overlap).;gbkey=CDS;locus_tag=Rv1951c;product=Conserved hypothetical protein;protein_id=CCP44718.1;transl_table=11
AL123456.3	EMBL	gene	2200726	2200941	.	+	.	ID=gene-Rv1952;Name=vapB14;gbkey=Gene;gene=vapB14;gene_biotype=protein_coding;locus_tag=Rv1952
AL123456.3	EMBL	CDS	2200726	2200941	.	+	0	ID=cds-CCP44719.1;Parent=gene-Rv1952;Dbxref=EnsemblGenomes-Gn:Rv1952,EnsemblGenomes-Tr:CCP44719,GOA:P95262,InterPro:IPR010985,NCBI_GP:CCP44719.1;Name=CCP44719.1;Note=Rv1952%2C (MTCY09F9.12c)%2C len: 71 aa. Possible vapB14%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1953 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in M. tuberculosis e.g. Rv2601A. Some similarity to P55510|Y4JJ_RHISN putative plasmid stability protein (85 aa)%2C FASTA scores: opt: 127%2C E(): 0.00096%2C (42.5%25 identity in 73 aa overlap).;gbkey=CDS;gene=vapB14;locus_tag=Rv1952;product=Possible antitoxin VapB14;protein_id=CCP44719.1;transl_table=11
AL123456.3	EMBL	gene	2200938	2201249	.	+	.	ID=gene-Rv1953;Name=vapC14;gbkey=Gene;gene=vapC14;gene_biotype=protein_coding;locus_tag=Rv1953
AL123456.3	EMBL	CDS	2200938	2201249	.	+	0	ID=cds-CCP44720.1;Parent=gene-Rv1953;Dbxref=EnsemblGenomes-Gn:Rv1953,EnsemblGenomes-Tr:CCP44720,GOA:P9WF99,InterPro:IPR029060,NCBI_GP:CCP44720.1;Name=CCP44720.1;Note=Rv1953%2C (MTCY09F9.11c)%2C len: 103 aa. Possible vapC14%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv1952%2C contains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Some similarity to O33827 plasmid stability-like protein from Thiobacillus ferrooxidans (143 aa)%2C FASTA scores: opt: 170%2C E(): 3.5e-06%2C (45.3%25 identity in 75 aa overlap).;gbkey=CDS;gene=vapC14;locus_tag=Rv1953;product=Possible toxin VapC14;protein_id=CCP44720.1;transl_table=11
AL123456.3	EMBL	gene	2201223	2201744	.	-	.	ID=gene-Rv1954c;Name=Rv1954c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1954c
AL123456.3	EMBL	CDS	2201223	2201744	.	-	0	ID=cds-CCP44721.1;Parent=gene-Rv1954c;Dbxref=EnsemblGenomes-Gn:Rv1954c,EnsemblGenomes-Tr:CCP44721,NCBI_GP:CCP44721.1;Name=CCP44721.1;Note=Rv1954c%2C (MTCY09F9.10)%2C len: 173 aa. Hypothetical unknown protein%2C end overlaps next ORF upstream%2C Rv1955 (MTCY09F9.09c).;gbkey=CDS;locus_tag=Rv1954c;product=Hypothetical protein;protein_id=CCP44721.1;transl_table=11
AL123456.3	EMBL	gene	2201277	2201579	.	+	.	ID=gene-Rv1954A;Name=Rv1954A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1954A
AL123456.3	EMBL	CDS	2201277	2201579	.	+	0	ID=cds-CCP44722.1;Parent=gene-Rv1954A;Dbxref=EnsemblGenomes-Gn:Rv1954A,EnsemblGenomes-Tr:CCP44722,NCBI_GP:CCP44722.1;Name=CCP44722.1;Note=Rv1954A%2C len: 100 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1954A;product=Hypothetical protein;protein_id=CCP44722.1;transl_table=11
AL123456.3	EMBL	gene	2201719	2202096	.	+	.	ID=gene-Rv1955;Name=higB;gbkey=Gene;gene=higB;gene_biotype=protein_coding;locus_tag=Rv1955
AL123456.3	EMBL	CDS	2201719	2202096	.	+	0	ID=cds-CCP44723.1;Parent=gene-Rv1955;Dbxref=EnsemblGenomes-Gn:Rv1955,EnsemblGenomes-Tr:CCP44723,GOA:P9WJA5,InterPro:IPR009241,NCBI_GP:CCP44723.1;Name=CCP44723.1;Note=Rv1955%2C (MTCY09F9.09c)%2C len: 125 aa. Possible higB%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1956 (See Pandey and Gerdes%2C 2005%3B Gupta%2C 2009). Start overlaps another ORF%2C Rv1954c (MTCY09F9.10). Start changed since first submission (-45 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008). Upon expression in E. coli has been shown to function as an antitoxin against Rv1956 (PubMed: 19016878)%3B It is not clear if these conflicting results are due to expression in a heterologous system%3B In various publications%2C both gene names higA and higB have been assigned to both Rv1955 and Rv1956%3B we have chosen to call Rv1955 higB after consulting the authors.;gbkey=CDS;gene=higB;locus_tag=Rv1955;product=Possible toxin HigB;protein_id=CCP44723.1;transl_table=11
AL123456.3	EMBL	gene	2202138	2202587	.	+	.	ID=gene-Rv1956;Name=higA;gbkey=Gene;gene=higA;gene_biotype=protein_coding;locus_tag=Rv1956
AL123456.3	EMBL	CDS	2202138	2202587	.	+	0	ID=cds-CCP44724.1;Parent=gene-Rv1956;Dbxref=EnsemblGenomes-Gn:Rv1956,EnsemblGenomes-Tr:CCP44724,GOA:P9WJA7,InterPro:IPR001387,InterPro:IPR010982,NCBI_GP:CCP44724.1;Name=CCP44724.1;Note=Rv1956%2C (MTCY09F9.08c)%2C len: 149 aa. Possible higA%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1955 (See Pandey and Gerdes%2C 2005%3B Gupta%2C 2009). Possible transcriptional regulatory protein%2C contains probable helix-turn-helix motif at aa 52-73 (+4.78 SD). Upon expression in E.coli Rv1956 has been shown to function as a toxin inhibiting cell growth and colony formation that is neutralized by coexpression with Rv1955 (PubMed: 19016878)%3B It is not clear if these conflicting results are due to expression in a heterologous system. The gene names higA and higB have been assigned to both Rv1955 and Rv1956%3B we have chosen to call Rv1956 higA after consulting the authors.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=higA;locus_tag=Rv1956;product=Possible antitoxin HigA;protein_id=CCP44724.1;transl_table=11
AL123456.3	EMBL	gene	2202584	2203129	.	+	.	ID=gene-Rv1957;Name=Rv1957;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1957
AL123456.3	EMBL	CDS	2202584	2203129	.	+	0	ID=cds-CCP44725.1;Parent=gene-Rv1957;Dbxref=EnsemblGenomes-Gn:Rv1957,EnsemblGenomes-Tr:CCP44725,GOA:P95257,InterPro:IPR003708,NCBI_GP:CCP44725.1;Name=CCP44725.1;Note=Rv1957%2C (MTCY09F9.07c)%2C len: 181 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1957;product=Hypothetical protein;protein_id=CCP44725.1;transl_table=11
AL123456.3	EMBL	gene	2203018	2203632	.	-	.	ID=gene-Rv1958c;Name=Rv1958c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1958c
AL123456.3	EMBL	CDS	2203018	2203632	.	-	0	ID=cds-CCP44726.1;Parent=gene-Rv1958c;Dbxref=EnsemblGenomes-Gn:Rv1958c,EnsemblGenomes-Tr:CCP44726,UniProtKB/TrEMBL:P95256,NCBI_GP:CCP44726.1;Name=CCP44726.1;Note=Rv1958c%2C (MTCY09F9.06)%2C len: 204 aa. Hypothetical unknown protein%2C questionable ORF;gbkey=CDS;locus_tag=Rv1958c;product=Hypothetical protein;protein_id=CCP44726.1;transl_table=11
AL123456.3	EMBL	gene	2203681	2203977	.	-	.	ID=gene-Rv1959c;Name=parE1;gbkey=Gene;gene=parE1;gene_biotype=protein_coding;locus_tag=Rv1959c
AL123456.3	EMBL	CDS	2203681	2203977	.	-	0	ID=cds-CCP44727.1;Parent=gene-Rv1959c;Dbxref=EnsemblGenomes-Gn:Rv1959c,EnsemblGenomes-Tr:CCP44727,GOA:P9WHG7,InterPro:IPR007712,InterPro:IPR028344,NCBI_GP:CCP44727.1;Name=CCP44727.1;Note=Rv1959c%2C (MTCY09F9.05)%2C len: 98 aa. Possible parE1%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1960c (See Pandey and Gerdes%2C 2005)%2C similar to other hypothetical plasmid proteins e.g. AL117189|YPCD1.08 from Yersinia pestis (99 aa)%2C FASTA scores: opt: 162%2C E(): 7.3e-05%2C (33.0%25 identity in 91 aa overlap)%3B also some similarity to E145339 hypothetical protein (103 aa)%2C FASTA scores: opt: 142%2C E(): 0.0003%2C (33.0%25 identity in 91 aa overlap).;gbkey=CDS;gene=parE1;locus_tag=Rv1959c;product=Possible toxin ParE1;protein_id=CCP44727.1;transl_table=11
AL123456.3	EMBL	gene	2203974	2204225	.	-	.	ID=gene-Rv1960c;Name=parD1;gbkey=Gene;gene=parD1;gene_biotype=protein_coding;locus_tag=Rv1960c
AL123456.3	EMBL	CDS	2203974	2204225	.	-	0	ID=cds-CCP44728.1;Parent=gene-Rv1960c;Dbxref=EnsemblGenomes-Gn:Rv1960c,EnsemblGenomes-Tr:CCP44728,GOA:P9WIJ7,InterPro:IPR005360,InterPro:IPR010985,InterPro:IPR022789,NCBI_GP:CCP44728.1;Name=CCP44728.1;Note=Rv1960c%2C (MTCY09F9.04)%2C len: 83 aa. Possible parD1%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv1959c (See Pandey and Gerdes%2C 2005)%2C similar to O85269|AF102990|AF102990_51 hypothetical protein of Yersinia enterocolitica (80 aa)%2C FASTA scores: opt: 149%2CE(): 0.00037%2C (42.1%25 identity in 57 aa overlap).;gbkey=CDS;gene=parD1;locus_tag=Rv1960c;product=Possible antitoxin ParD1;protein_id=CCP44728.1;transl_table=11
AL123456.3	EMBL	gene	2204212	2204706	.	+	.	ID=gene-Rv1961;Name=Rv1961;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1961
AL123456.3	EMBL	CDS	2204212	2204706	.	+	0	ID=cds-CCP44729.1;Parent=gene-Rv1961;Dbxref=EnsemblGenomes-Gn:Rv1961,EnsemblGenomes-Tr:CCP44729,UniProtKB/TrEMBL:P95253,NCBI_GP:CCP44729.1;Name=CCP44729.1;Note=Rv1961%2C MTCY09F9.03c%2C len: 164 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv1961;product=Hypothetical protein;protein_id=CCP44729.1;transl_table=11
AL123456.3	EMBL	gene	2204866	2205273	.	-	.	ID=gene-Rv1962c;Name=vapC35;gbkey=Gene;gene=vapC35;gene_biotype=protein_coding;locus_tag=Rv1962c
AL123456.3	EMBL	CDS	2204866	2205273	.	-	0	ID=cds-CCP44730.1;Parent=gene-Rv1962c;Dbxref=EnsemblGenomes-Gn:Rv1962c,EnsemblGenomes-Tr:CCP44730,GOA:P9WF67,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44730.1;Name=CCP44730.1;Note=Rv1962c%2C (MTCY09F9.02)%2C len: 135 aa. Possible vapC35%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv1962A%2C contains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv3408|MTCY78.20c (133 aa) (36.2%25 identity in 138 aa overlap)%3B and Rv3384c (130 aa) (43.1%25 identity in 130 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC35;locus_tag=Rv1962c;product=Possible toxin VapC35. Contains PIN domain.;protein_id=CCP44730.1;transl_table=11
AL123456.3	EMBL	gene	2205277	2205549	.	-	.	ID=gene-Rv1962A;Name=vapB35;gbkey=Gene;gene=vapB35;gene_biotype=protein_coding;locus_tag=Rv1962A
AL123456.3	EMBL	CDS	2205277	2205549	.	-	0	ID=cds-CCP44731.1;Parent=gene-Rv1962A;Dbxref=EnsemblGenomes-Gn:Rv1962A,EnsemblGenomes-Tr:CCP44731,GOA:P9WF17,InterPro:IPR006442,NCBI_GP:CCP44731.1;Name=CCP44731.1;Note=Rv1962A%2C len: 90 aa. Possible vapB35%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv1962c%2C see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. Rv3385c%2C Rv3407%2C Rv0626;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB35;locus_tag=Rv1962A;product=Possible antitoxin VapB35;protein_id=CCP44731.1;transl_table=11
AL123456.3	EMBL	gene	2205582	2206802	.	-	.	ID=gene-Rv1963c;Name=mce3R;gbkey=Gene;gene=mce3R;gene_biotype=protein_coding;locus_tag=Rv1963c
AL123456.3	EMBL	CDS	2205582	2206802	.	-	0	ID=cds-CCP44732.1;Parent=gene-Rv1963c;Dbxref=EnsemblGenomes-Gn:Rv1963c,EnsemblGenomes-Tr:CCP44732,GOA:P95251,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:P95251,NCBI_GP:CCP44732.1;Name=CCP44732.1;Note=Rv1963c%2C (MTV051.01c-MTCY09F9.01)%2C len: 406 aa. Probable mce3R%2C negative transcriptional regulatory protein%2C TetR family (see citation below)%3B similar to several transcriptional regulator e.g. AL049485|SC6A5.30 Streptomyces coelicolor cosmid 6 a (404 aa)%2C FASTA scores: opt: 319%2C E(): 6.4e-13%2C (29.5%25 identity in 373 aa overlap)%3B and Z84498|MTCY9F9_1 (259 aa)%2C FASTA scores: opt: 208%2C E(): 1.6e-07%2C (100.0%25 identity in 32 aa overlap). Contains probable helix-turn-helix at aa 36-57 (+4.23 SD) and two tet-R family signatures.;gbkey=CDS;gene=mce3R;locus_tag=Rv1963c;product=Probable transcriptional repressor (probably TetR-family) Mce3R;protein_id=CCP44732.1;transl_table=11
AL123456.3	EMBL	gene	2207700	2208497	.	+	.	ID=gene-Rv1964;Name=yrbE3A;gbkey=Gene;gene=yrbE3A;gene_biotype=protein_coding;locus_tag=Rv1964
AL123456.3	EMBL	CDS	2207700	2208497	.	+	0	ID=cds-CCP44733.1;Parent=gene-Rv1964;Dbxref=EnsemblGenomes-Gn:Rv1964,EnsemblGenomes-Tr:CCP44733,InterPro:IPR003453,UniProtKB/TrEMBL:O53965,NCBI_GP:CCP44733.1;Name=CCP44733.1;Note=Rv1964%2C (MTV051.02)%2C len: 265 aa. YrbE3A%2Chypothetical unknown integral membrane protein%2C part of mce3 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa)%2CO07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa)%2CRv3501c|MTV023.08c|yrbE4A (254 aa)%2C etc. Also highly similar to conserved hypothetical integral membrane proteins of yrbEA type%2C e.g. AAD24544.1|AF116213|YrbE1A from Mycobacterium leprae (112 aa)%3B P45392|YRBE_ECOLI from Escherichia coli (260 aa)%2C FASTA scores: opt: 893%2C E(): 0%2C(51.4%25 identity in 253 aa overlap)%3B etc. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002).;gbkey=CDS;gene=yrbE3A;locus_tag=Rv1964;product=Conserved hypothetical integral membrane protein YrbE3A;protein_id=CCP44733.1;transl_table=11
AL123456.3	EMBL	gene	2208507	2209322	.	+	.	ID=gene-Rv1965;Name=yrbE3B;gbkey=Gene;gene=yrbE3B;gene_biotype=protein_coding;locus_tag=Rv1965
AL123456.3	EMBL	CDS	2208507	2209322	.	+	0	ID=cds-CCP44734.1;Parent=gene-Rv1965;Dbxref=EnsemblGenomes-Gn:Rv1965,EnsemblGenomes-Tr:CCP44734,InterPro:IPR003453,UniProtKB/TrEMBL:O53966,NCBI_GP:CCP44734.1;Name=CCP44734.1;Note=Rv1965%2C (MTV051.03)%2C len: 271 aa. YrbE4B%2Chypothetical unknown integral membrane protein%2C part of mce3 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa)%2C FASTA scores: opt: 937%2C E(): 0%2C (54.3%25 identity in 254 aa overlap)%3B O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa)%3B etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type%2C e.g. AAD24545.1|AF116213|YrbE1B from Mycobacterium leprae (106 aa)%3B P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from Escherichia coli (260 aa)%2C FASTA scores: opt: 218%2C E(): 1.2e-07%2C (24.1%25 identity in 245 aa overlap)%3B etc. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yrbE3B;locus_tag=Rv1965;product=Conserved hypothetical integral membrane protein YrbE3B;protein_id=CCP44734.1;transl_table=11
AL123456.3	EMBL	gene	2209327	2210604	.	+	.	ID=gene-Rv1966;Name=mce3A;gbkey=Gene;gene=mce3A;gene_biotype=protein_coding;gene_synonym=mce3;locus_tag=Rv1966
AL123456.3	EMBL	CDS	2209327	2210604	.	+	0	ID=cds-CCP44735.1;Parent=gene-Rv1966;Dbxref=EnsemblGenomes-Gn:Rv1966,EnsemblGenomes-Tr:CCP44735,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR024516,UniProtKB/TrEMBL:L7N698,NCBI_GP:CCP44735.1;Name=CCP44735.1;Note=Rv1966%2C (MTV051.04)%2C len: 425 aa. Mce3A%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa)%3B O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa)%3B etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa)%3B NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa)%3B CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa)%3B etc. Contains a possible N-terminal signal sequence or membrane anchor. Note that previously known as mce3. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002). Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;gene=mce3A;locus_tag=Rv1966;product=Mce-family protein Mce3A;protein_id=CCP44735.1;transl_table=11
AL123456.3	EMBL	gene	2210601	2211629	.	+	.	ID=gene-Rv1967;Name=mce3B;gbkey=Gene;gene=mce3B;gene_biotype=protein_coding;locus_tag=Rv1967
AL123456.3	EMBL	CDS	2210601	2211629	.	+	0	ID=cds-CCP44736.1;Parent=gene-Rv1967;Dbxref=EnsemblGenomes-Gn:Rv1967,EnsemblGenomes-Tr:CCP44736,GOA:O53968,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O53968,NCBI_GP:CCP44736.1;Name=CCP44736.1;Note=Rv1967%2C (MTV051.05)%2C len: 342 aa. Mce3B%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa)%3B O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa)%3B etc. Also similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa)%3B CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa)%3B etc. Contains a possible N-terminal signal sequence or membrane anchor. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002). Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce3B;locus_tag=Rv1967;product=Mce-family protein Mce3B;protein_id=CCP44736.1;transl_table=11
AL123456.3	EMBL	gene	2211626	2212858	.	+	.	ID=gene-Rv1968;Name=mce3C;gbkey=Gene;gene=mce3C;gene_biotype=protein_coding;locus_tag=Rv1968
AL123456.3	EMBL	CDS	2211626	2212858	.	+	0	ID=cds-CCP44737.1;Parent=gene-Rv1968;Dbxref=EnsemblGenomes-Gn:Rv1968,EnsemblGenomes-Tr:CCP44737,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR008360,UniProtKB/TrEMBL:O53969,NCBI_GP:CCP44737.1;Name=CCP44737.1;Note=Rv1968%2C (MTV051.06)%2C len: 410 aa. Mce3C%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa)%3B O07787|Rv0591|MTCY19H5.31|mce2C (481 aa)%3B etc. Also similar to others e.g. CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa)%3B NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa)%3B etc. Contains a possible N-terminal signal sequence or membrane anchor. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002). Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;gene=mce3C;locus_tag=Rv1968;product=Mce-family protein Mce3C;protein_id=CCP44737.1;transl_table=11
AL123456.3	EMBL	gene	2212855	2214126	.	+	.	ID=gene-Rv1969;Name=mce3D;gbkey=Gene;gene=mce3D;gene_biotype=protein_coding;locus_tag=Rv1969
AL123456.3	EMBL	CDS	2212855	2214126	.	+	0	ID=cds-CCP44738.1;Parent=gene-Rv1969;Dbxref=EnsemblGenomes-Gn:Rv1969,EnsemblGenomes-Tr:CCP44738,GOA:O53970,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O53970,NCBI_GP:CCP44738.1;Name=CCP44738.1;Note=Rv1969%2C (MTV051.07)%2C len: 423 aa. Mce3D%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa)%3B O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa)%3B etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa)%3B CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa)%3B etc. Contains a possible N-terminal signal sequence or membrane anchor. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002). Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;gene=mce3D;locus_tag=Rv1969;product=Mce-family protein Mce3D;protein_id=CCP44738.1;transl_table=11
AL123456.3	EMBL	gene	2214123	2215256	.	+	.	ID=gene-Rv1970;Name=lprM;gbkey=Gene;gene=lprM;gene_biotype=protein_coding;gene_synonym=mce3E;locus_tag=Rv1970
AL123456.3	EMBL	CDS	2214123	2215256	.	+	0	ID=cds-CCP44739.1;Parent=gene-Rv1970;Dbxref=EnsemblGenomes-Gn:Rv1970,EnsemblGenomes-Tr:CCP44739,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O53971,NCBI_GP:CCP44739.1;Name=CCP44739.1;Note=Rv1970%2C (MTV051.08)%2C len: 377 aa. Possible lprM (alternate gene name: mce3E)%2C lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa)%3B O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa)%3B etc. Also highly similar to others e.g. NP_302660.1|NC_002677 putative lipoprotein from Mycobacterium leprae (392 aa)%3B CAC12794.1|AL445327 putative secreted protein from Streptomyces coelicolor (413 aa)%3B etc. Contains possible N-terminal signal sequence or membrane anchor and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002).;gbkey=CDS;gene=lprM;inference=protein motif:PROSITE:PS00013;locus_tag=Rv1970;product=Possible Mce-family lipoprotein LprM (Mce-family lipoprotein Mce3E);protein_id=CCP44739.1;transl_table=11
AL123456.3	EMBL	gene	2215257	2216570	.	+	.	ID=gene-Rv1971;Name=mce3F;gbkey=Gene;gene=mce3F;gene_biotype=protein_coding;locus_tag=Rv1971
AL123456.3	EMBL	CDS	2215257	2216570	.	+	0	ID=cds-CCP44740.1;Parent=gene-Rv1971;Dbxref=EnsemblGenomes-Gn:Rv1971,EnsemblGenomes-Tr:CCP44740,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:O53972,NCBI_GP:CCP44740.1;Name=CCP44740.1;Note=Rv1971%2C (MTV051.09)%2C len: 437 aa. Mce3F%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa)%2C O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa)%3B etc. Also highly similar to others e.g. NP_302661.1|NC_002677 putative secreted protein from Mycobacterium leprae (516 aa)%3B CAC12793.1|AL445327 putative secreted protein from Streptomyces coelicolor (433 aa)%3B etc. Contains a possible N-terminal signal sequence or membrane anchor. The transcription of this CDS seems negatively regulated by the product of Rv1963c|mce3R (see Santangelo et al.%2C 2002). Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;gene=mce3F;locus_tag=Rv1971;product=Mce-family protein Mce3F;protein_id=CCP44740.1;transl_table=11
AL123456.3	EMBL	gene	2216592	2217167	.	+	.	ID=gene-Rv1972;Name=Rv1972;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1972
AL123456.3	EMBL	CDS	2216592	2217167	.	+	0	ID=cds-CCP44741.1;Parent=gene-Rv1972;Dbxref=EnsemblGenomes-Gn:Rv1972,EnsemblGenomes-Tr:CCP44741,UniProtKB/TrEMBL:O53973,NCBI_GP:CCP44741.1;Name=CCP44741.1;Note=Rv1972%2C (MTV051.10)%2C len: 191 aa. Probable conserved Mce-associated membrane protein. Probably part of mce3 operon. Similar to several Mycobacterium tuberculosis proteins e.g. Rv1363c|Z75555|MTCY02B10.27C (261 aa)%2C FASTA scores: opt: 342%2C E(): 1.2e-15%2C (31.8%25 identity in 195 aa overlap)%3B Rv1362c%2C Rv0177 (near Mce operon 1)%2C etc. Has hydrophobic stretch at aa 20-40.;gbkey=CDS;locus_tag=Rv1972;product=Probable conserved Mce associated membrane protein;protein_id=CCP44741.1;transl_table=11
AL123456.3	EMBL	gene	2217164	2217646	.	+	.	ID=gene-Rv1973;Name=Rv1973;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1973
AL123456.3	EMBL	CDS	2217164	2217646	.	+	0	ID=cds-CCP44742.1;Parent=gene-Rv1973;Dbxref=EnsemblGenomes-Gn:Rv1973,EnsemblGenomes-Tr:CCP44742,GOA:P9WJ77,NCBI_GP:CCP44742.1;Name=CCP44742.1;Note=Rv1973%2C (MTV051.11)%2C len: 160 aa. Possible conserved Mce-associated membrane protein. Probably part of mce3 operon. Similar to several other proteins from Mycobacterium tuberculosis e.g. Rv1362c|Z75555|MTCY02B10.26C (220 aa)%2C FASTA scores: opt: 378%2C E(): 2.8e-19%2C (50.0%25 identity in 128 aa overlap)%3B Rv1363c%3B Rv0177 (near Mce operon 1)%3B etc. Contains possible N-terminal signal sequence or membrane anchor. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1973;product=Possible conserved Mce associated membrane protein;protein_id=CCP44742.1;transl_table=11
AL123456.3	EMBL	gene	2217659	2218036	.	+	.	ID=gene-Rv1974;Name=Rv1974;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1974
AL123456.3	EMBL	CDS	2217659	2218036	.	+	0	ID=cds-CCP44743.1;Parent=gene-Rv1974;Dbxref=EnsemblGenomes-Gn:Rv1974,EnsemblGenomes-Tr:CCP44743,InterPro:IPR007969,UniProtKB/TrEMBL:O53975,NCBI_GP:CCP44743.1;Name=CCP44743.1;Note=Rv1974%2C (MTV051.12)%2C len: 125 aa. Probable conserved membrane protein%2C weakly similar to other Mycobacterium tuberculosis proteins e.g. Rv1271c|Z77137|MTCY50.11 (113 aa)%2C FASTA scores: opt: 98%2C E(): 1.4%2C (24.5%25 identity in 110 aa overlap)%3B Rv1804c%3B Rv1690. Has possible signal peptide or transmembrane stretch from aa 12-30. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1974;product=Probable conserved membrane protein;protein_id=CCP44743.1;transl_table=11
AL123456.3	EMBL	gene	2218052	2218717	.	+	.	ID=gene-Rv1975;Name=Rv1975;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1975
AL123456.3	EMBL	CDS	2218052	2218717	.	+	0	ID=cds-CCP44744.1;Parent=gene-Rv1975;Dbxref=EnsemblGenomes-Gn:Rv1975,EnsemblGenomes-Tr:CCP44744,InterPro:IPR014044,UniProtKB/TrEMBL:O53976,NCBI_GP:CCP44744.1;Name=CCP44744.1;Note=Rv1975%2C (MTV051.13)%2C len: 221 aa. Conserved hypothetical protein%2C showing some similarity to AJ251435 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (193 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv1975;product=Conserved hypothetical protein;protein_id=CCP44744.1;transl_table=11
AL123456.3	EMBL	gene	2218844	2219251	.	-	.	ID=gene-Rv1976c;Name=Rv1976c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1976c
AL123456.3	EMBL	CDS	2218844	2219251	.	-	0	ID=cds-CCP44745.1;Parent=gene-Rv1976c;Dbxref=EnsemblGenomes-Gn:Rv1976c,EnsemblGenomes-Tr:CCP44745,InterPro:IPR010298,UniProtKB/TrEMBL:O53977,NCBI_GP:CCP44745.1;Name=CCP44745.1;Note=Rv1976c%2C (MTV051.14)%2C len: 135 aa. Conserved hypothetical protein%2C similar to SC1C3.03c|AL023702 hypothetical protein from Streptomyces coelicolor (125 aa)%2CFASTA score: opt: 223%2C E(): 3.3e-08%2C (39.6%25 identity in 111 aa overlap).;gbkey=CDS;locus_tag=Rv1976c;product=Conserved hypothetical protein;protein_id=CCP44745.1;transl_table=11
AL123456.3	EMBL	gene	2219754	2220800	.	+	.	ID=gene-Rv1977;Name=Rv1977;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1977
AL123456.3	EMBL	CDS	2219754	2220800	.	+	0	ID=cds-CCP44746.1;Parent=gene-Rv1977;Dbxref=EnsemblGenomes-Gn:Rv1977,EnsemblGenomes-Tr:CCP44746,GOA:O53978,InterPro:IPR001915,UniProtKB/TrEMBL:O53978,NCBI_GP:CCP44746.1;Name=CCP44746.1;Note=Rv1977%2C (MTV051.15)%2C len: 348 aa. Conserved protein%2Csimilar to SCC123.20|AL136518 hypothetical protein from Streptomyces coelicolor (402 aa)%2C blastp scores: Score %3D 311 bits (789)%2C Expect %3D 5e-84 Identities %3D 156/316 (49%25)%2CPositives %3D 212/316 (66%25)%3B and PCC6803|D90907_31 Synechocystis sp. (303 aa)%2C FASTA scores: opt: 533%2C E(): 4.7e- 29%2C (38.5%25 identity in 275 aa overlap). Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Alternative nucleotide at position 2219929 (T->C%3B L59P) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv1977;product=Conserved protein;protein_id=CCP44746.1;transl_table=11
AL123456.3	EMBL	gene	2220908	2221756	.	+	.	ID=gene-Rv1978;Name=Rv1978;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1978
AL123456.3	EMBL	CDS	2220908	2221756	.	+	0	ID=cds-CCP44747.1;Parent=gene-Rv1978;Dbxref=EnsemblGenomes-Gn:Rv1978,EnsemblGenomes-Tr:CCP44747,GOA:O53979,InterPro:IPR013217,InterPro:IPR029063,UniProtKB/TrEMBL:O53979,NCBI_GP:CCP44747.1;Name=CCP44747.1;Note=Rv1978%2C (MTV051.16)%2C len: 282 aa. Conserved protein%2Csimilar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa)%2C FASTA scores: opt: 151%2CE(): 0.0072%2C (30.6%25 identity in 121 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1978;product=Conserved protein;protein_id=CCP44747.1;transl_table=11
AL123456.3	EMBL	gene	2221719	2223164	.	-	.	ID=gene-Rv1979c;Name=Rv1979c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1979c
AL123456.3	EMBL	CDS	2221719	2223164	.	-	0	ID=cds-CCP44748.1;Parent=gene-Rv1979c;Dbxref=EnsemblGenomes-Gn:Rv1979c,EnsemblGenomes-Tr:CCP44748,GOA:P9WQM5,InterPro:IPR002293,NCBI_GP:CCP44748.1;Name=CCP44748.1;Note=Rv1979c%2C (MTCY39.40-MTV051.17c)%2C len: 481 aa. Possible permease%2C APC family possibly involved in transport of amino acid%2C showing some similarity to other permeases. Also similar to MTCY39.19 from Mycobacterium tuberculosis (28.2%25 identity in 277 aa overlap). Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. Nucleotide position 2221796 in the genome sequence has been corrected%2C C:T resulting in V457I.;gbkey=CDS;inference=protein motif:PROSITE:PS00599;locus_tag=Rv1979c;product=Possible conserved permease;protein_id=CCP44748.1;transl_table=11
AL123456.3	EMBL	gene	2223343	2224029	.	-	.	ID=gene-Rv1980c;Name=mpt64;gbkey=Gene;gene=mpt64;gene_biotype=protein_coding;gene_synonym=mpb64;locus_tag=Rv1980c
AL123456.3	EMBL	CDS	2223343	2224029	.	-	0	ID=cds-CCP44749.1;Parent=gene-Rv1980c;Dbxref=EnsemblGenomes-Gn:Rv1980c,EnsemblGenomes-Tr:CCP44749,GOA:P9WIN9,InterPro:IPR021729,PDB:2HHI,NCBI_GP:CCP44749.1;Name=CCP44749.1;Note=Rv1980c%2C (MT2032%2C MTCY39.39)%2C len: 228 aa. Mpt64 (alternate gene name: mpb64)%2C immunogenic protein (alternate gene name: mpb64) (see citations below)%2Cidentical to MPT64|MPB64 from Mycobacterium bovis (228 aa). Similar to Rv3036c|MTV012.51c from Mycobacterium tuberculosis. Exported protein containing a N-terminal signal sequence: see notes below about proteomics. Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mpt64;locus_tag=Rv1980c;product=Immunogenic protein Mpt64 (antigen Mpt64/MPB64);protein_id=CCP44749.1;transl_table=11
AL123456.3	EMBL	gene	2224220	2225188	.	-	.	ID=gene-Rv1981c;Name=nrdF1;gbkey=Gene;gene=nrdF1;gene_biotype=protein_coding;gene_synonym=nrdF;locus_tag=Rv1981c
AL123456.3	EMBL	CDS	2224220	2225188	.	-	0	ID=cds-CCP44750.1;Parent=gene-Rv1981c;Dbxref=EnsemblGenomes-Gn:Rv1981c,EnsemblGenomes-Tr:CCP44750,GOA:P9WH73,InterPro:IPR000358,InterPro:IPR009078,InterPro:IPR012348,InterPro:IPR026023,InterPro:IPR026494,NCBI_GP:CCP44750.1;Name=CCP44750.1;Note=Rv1981c%2C (MTCY39.38)%2C len: 322 aa. NrdF1%2Cribonucleoside-diphosphate reductase%2C beta chain (see citation below)%2C highly similar to others e.g. RIR4_SALTY|P17424 ribonucleoside-diphosphate reductase (319 aa)%2C FASTA scores: opt: 1402%2C E(): 0%2C (66.0%25 identity in 315 aa overlap)%3B etc. Also similar to Rv3048c|MTV012.63c from Mycobacterium tuberculosis. Contains PS00368 Ribonucleotide reductase small subunit signature. Belongs to the ribonucleoside diphosphate reductase small chain family. Cofactor: binds 2 iron ions (by similarity). Note that previously known as nrdF.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrdF1;inference=protein motif:PROSITE:PS00368;locus_tag=Rv1981c;product=Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein);protein_id=CCP44750.1;transl_table=11
AL123456.3	EMBL	gene	2225413	2225832	.	-	.	ID=gene-Rv1982c;Name=vapC36;gbkey=Gene;gene=vapC36;gene_biotype=protein_coding;locus_tag=Rv1982c
AL123456.3	EMBL	CDS	2225413	2225832	.	-	0	ID=cds-CCP44751.1;Parent=gene-Rv1982c;Dbxref=EnsemblGenomes-Gn:Rv1982c,EnsemblGenomes-Tr:CCP44751,GOA:P9WF65,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44751.1;Name=CCP44751.1;Note=Rv1982c%2C (MTCY39.37)%2C len: 139 aa. Possible vapC36%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv1982A%2Ccontains PIN domain%2C see Arcus et al. 2005. belongs to the UPF0110 family. Similar to Rv0624|Z92772|MTY20H10.05 from Mycobacterium tuberculosis (131 aa)%2C FASTA scores: opt: 288%2C E(): 4.1e-14%2C (40.2%25 identity in 127 aa overlap)%3B also similar to Rv0624%2C Rv2759c%2C and Rv0609;gbkey=CDS;gene=vapC36;locus_tag=Rv1982c;product=Possible toxin VapC36. Contains PIN domain.;protein_id=CCP44751.1;transl_table=11
AL123456.3	EMBL	gene	2225841	2226101	.	-	.	ID=gene-Rv1982A;Name=vapB36;gbkey=Gene;gene=vapB36;gene_biotype=protein_coding;locus_tag=Rv1982A
AL123456.3	EMBL	CDS	2225841	2226101	.	-	0	ID=cds-CCP44752.1;Parent=gene-Rv1982A;Dbxref=EnsemblGenomes-Gn:Rv1982A,EnsemblGenomes-Tr:CCP44752,InterPro:IPR011660,NCBI_GP:CCP44752.1;Name=CCP44752.1;Note=Rv1982A%2C len: 86 aa. Possible vapB36%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv1982c%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. Rv0623%2C Rv2760c%2C Rv0608;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB36;locus_tag=Rv1982A;product=Possible antitoxin VapB36;protein_id=CCP44752.1;transl_table=11
AL123456.3	EMBL	gene	2226244	2227920	.	+	.	ID=gene-Rv1983;Name=PE_PGRS35;gbkey=Gene;gene=PE_PGRS35;gene_biotype=protein_coding;locus_tag=Rv1983
AL123456.3	EMBL	CDS	2226244	2227920	.	+	0	ID=cds-CCP44753.1;Parent=gene-Rv1983;Dbxref=EnsemblGenomes-Gn:Rv1983,EnsemblGenomes-Tr:CCP44753,GOA:P9WIF1,InterPro:IPR000084,NCBI_GP:CCP44753.1;Name=CCP44753.1;Note=Rv1983%2C (MTCY39.36c)%2C len: 558 aa. PE_PGRS35%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002). Similar to other PE proteins e.g. Rv0977%2C etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS35;inference=protein motif:PROSITE:PS00141;locus_tag=Rv1983;product=PE-PGRS family protein PE_PGRS35;protein_id=CCP44753.1;transl_table=11
AL123456.3	EMBL	gene	2227908	2228561	.	-	.	ID=gene-Rv1984c;Name=cfp21;gbkey=Gene;gene=cfp21;gene_biotype=protein_coding;gene_synonym=clp1,culp1;locus_tag=Rv1984c
AL123456.3	EMBL	CDS	2227908	2228561	.	-	0	ID=cds-CCP44754.1;Parent=gene-Rv1984c;Dbxref=EnsemblGenomes-Gn:Rv1984c,EnsemblGenomes-Tr:CCP44754,GOA:P9WP43,InterPro:IPR000675,InterPro:IPR011150,InterPro:IPR029058,NCBI_GP:CCP44754.1;Name=CCP44754.1;Note=Rv1984c%2C (MTCY39.35)%2C len: 217 aa. Cfp21%2C probable cutinase precursor with N-terminal signal sequence%2C similar to P41744|CUTI_ALTBR cutinase precursor from Alternaria brassicicola (209 aa)%2C FASTA scores: opt: 283%2C E(): 2.2e-11%2C (32.6%25 identity in 193 aa overlap). Also similar to Mycobacterium tuberculosis proteins e.g. Rv3452%2C Rv3451%2CRv2301%2C Rv1758%2C Rv3724. Belongs to the cutinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cfp21;inference=protein motif:PROSITE:PS00155;locus_tag=Rv1984c;product=Probable cutinase precursor CFP21;protein_id=CCP44754.1;transl_table=11
AL123456.3	EMBL	gene	2228991	2229902	.	-	.	ID=gene-Rv1985c;Name=Rv1985c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1985c
AL123456.3	EMBL	CDS	2228991	2229902	.	-	0	ID=cds-CCP44755.1;Parent=gene-Rv1985c;Dbxref=EnsemblGenomes-Gn:Rv1985c,EnsemblGenomes-Tr:CCP44755,GOA:P9WMF5,InterPro:IPR000847,InterPro:IPR005119,InterPro:IPR011991,InterPro:IPR017685,PDB:3ISP,NCBI_GP:CCP44755.1;Name=CCP44755.1;Note=Rv1985c%2C (MTCY39.34)%2C len: 303 aa. Probable transcriptional regulatory protein%2C LysR family member. Similar to many regulatory proteins%2C especially ICIA_ECOLI|P24194 chromosome initiation inhibitor from Escherichia coli (297 aa)%2C FASTA scores: opt: 520%2C E(): 1.1e-28%2C (35.8%25 identity in 285 aa overlap)%3B and P94632|LYSG_CORGL lysine export regulator protein (290 aa)%2CFASTA scores: opt: 705%2C E(): 0%2C (42.7%25 identity in 288 aa overlap)%3B etc. Contains PS00044 Bacterial regulatory proteins%2C lysR family signature. Also contains helix-turn-helix motif at aa 22-43%2C(+5.52 SD). Belongs to the LysR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv1985c;product=Probable transcriptional regulatory protein (probably LysR-family);protein_id=CCP44755.1;transl_table=11
AL123456.3	EMBL	gene	2230011	2230610	.	+	.	ID=gene-Rv1986;Name=Rv1986;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1986
AL123456.3	EMBL	CDS	2230011	2230610	.	+	0	ID=cds-CCP44756.1;Parent=gene-Rv1986;Dbxref=EnsemblGenomes-Gn:Rv1986,EnsemblGenomes-Tr:CCP44756,GOA:P9WK31,InterPro:IPR001123,InterPro:IPR004777,NCBI_GP:CCP44756.1;Name=CCP44756.1;Note=Rv1986%2C (MTCY39.33c)%2C len: 199 aa. Probable conserved integral membrane protein%2C LysE family possibly involved in transport of Lysine%2C similar to P11667|YGGA_ECOLI hypothetical 23.2 kDa protein in sbm-fba intergenic region (211 aa)%2C FASTA scores: opt: 379%2C E(): 1.5e-19%2C (37.3%25 identity in 185 aa overlap)%3B and Q11154|Rv0488 hypothetical 20.9 kDa protein from M. tuberculosis (201 aa)%2C FASTA scores: opt: 784%2C E(): 0%2C(63.4%25 identity in 186 aa overlap). Belongs to the LYSE/YGGA family.;gbkey=CDS;locus_tag=Rv1986;product=Probable conserved integral membrane protein;protein_id=CCP44756.1;transl_table=11
AL123456.3	EMBL	gene	2231026	2231454	.	+	.	ID=gene-Rv1987;Name=Rv1987;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1987
AL123456.3	EMBL	CDS	2231026	2231454	.	+	0	ID=cds-CCP44757.1;Parent=gene-Rv1987;Dbxref=EnsemblGenomes-Gn:Rv1987,EnsemblGenomes-Tr:CCP44757,GOA:P9WLQ1,InterPro:IPR001919,InterPro:IPR008965,InterPro:IPR012291,NCBI_GP:CCP44757.1;Name=CCP44757.1;Note=Rv1987%2C (MTCY39.32c)%2C len: 142 aa. Possible chitinase%2C similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores%2C opt: 324%2C E(): 1.2e-14%2C (39.5%25 identity in 129 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1987;product=Possible chitinase;protein_id=CCP44757.1;transl_table=11
AL123456.3	EMBL	gene	2231680	2232219	.	+	.	ID=gene-Rv1988;Name=erm(37);gbkey=Gene;gene=erm(37);gene_biotype=protein_coding;locus_tag=Rv1988
AL123456.3	EMBL	CDS	2231680	2232219	.	+	0	ID=cds-CCP44758.1;Parent=gene-Rv1988;Dbxref=EnsemblGenomes-Gn:Rv1988,EnsemblGenomes-Tr:CCP44758,GOA:Q10838,InterPro:IPR001737,InterPro:IPR020598,InterPro:IPR029063,UniProtKB/TrEMBL:Q10838,NCBI_GP:CCP44758.1;Name=CCP44758.1;Note=Rv1988%2C (MTCY39.31c)%2C len: 179 aa. Probable erm(37)%2C23S rRNA methyltransferase%2C similar to ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 aa)%2C FASTA scores: opt: 259%2C E(): 2e-11%2C (35.1%25 identity in 171 aa overlap)%3B contains PS00092 N-6 Adenine-specific DNA methylases signature. Also similar to Mycobacterium tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=erm(37);inference=protein motif:PROSITE:PS00092;locus_tag=Rv1988;product=Probable 23S rRNA methyltransferase Erm(37);protein_id=CCP44758.1;transl_table=11
AL123456.3	EMBL	gene	2232739	2233299	.	-	.	ID=gene-Rv1989c;Name=Rv1989c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1989c
AL123456.3	EMBL	CDS	2232739	2233299	.	-	0	ID=cds-CCP44759.1;Parent=gene-Rv1989c;Dbxref=EnsemblGenomes-Gn:Rv1989c,EnsemblGenomes-Tr:CCP44759,GOA:P9WLP9,InterPro:IPR014914,NCBI_GP:CCP44759.1;Name=CCP44759.1;Note=Rv1989c%2C (MTCY39.30)%2C len: 186 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1989c;product=Hypothetical protein;protein_id=CCP44759.1;transl_table=11
AL123456.3	EMBL	gene	2233296	2233637	.	-	.	ID=gene-Rv1990c;Name=Rv1990c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1990c
AL123456.3	EMBL	CDS	2233296	2233637	.	-	0	ID=cds-CCP44760.1;Parent=gene-Rv1990c;Dbxref=EnsemblGenomes-Gn:Rv1990c,EnsemblGenomes-Tr:CCP44760,InterPro:IPR024467,NCBI_GP:CCP44760.1;Name=CCP44760.1;Note=Rv1990c%2C (MTCY39.29)%2C len: 113 aa. Probable transcriptional regulatory protein%2C similar to Mycobacterium tuberculosis Rv3188|AL021646|MTV014.32 (115 aa)%2C FASTA scores: opt: 184%2C E(): 8.2e-07%2C (28.4%25 identity in 109 aa overlap). Contains probable helix-turn-helix motif at aa 20-44 (+4.22 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1990c;product=Probable transcriptional regulatory protein;protein_id=CCP44760.1;transl_table=11
AL123456.3	EMBL	gene	2233881	2234216	.	-	.	ID=gene-Rv1990A;Name=Rv1990A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1990A
AL123456.3	EMBL	CDS	2233881	2234216	.	-	0	ID=cds-CCP44761.1;Parent=gene-Rv1990A;Dbxref=EnsemblGenomes-Gn:Rv1990A,EnsemblGenomes-Tr:CCP44761,InterPro:IPR016040,UniProtKB/TrEMBL:L7N6A3,NCBI_GP:CCP44761.1;Name=CCP44761.1;Note=Rv1990A%2C len: 111 aa. Possible dehydrogenase (fragment)%2C similar to N-terminal part of several dehydrogenases and hypothetical proteins%2C e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa)%2C FASTA scores: opt: 151%2C E(): 0.0045%2C (47.45%25 identity in 78 aa overlap)%2C but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa)%2C FASTA scores: opt: 142%2C E(): 0.018%2C(54.15%25 identity in 48 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv1990A;product=Possible dehydrogenase (fragment);protein_id=CCP44761.1;transl_table=11
AL123456.3	EMBL	gene	2234305	2234649	.	-	.	ID=gene-Rv1991c;Name=mazF6;gbkey=Gene;gene=mazF6;gene_biotype=protein_coding;gene_synonym=mt3;locus_tag=Rv1991c
AL123456.3	EMBL	CDS	2234305	2234649	.	-	0	ID=cds-CCP44762.1;Parent=gene-Rv1991c;Dbxref=EnsemblGenomes-Gn:Rv1991c,EnsemblGenomes-Tr:CCP44762,GOA:P9WII3,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP44762.1;Name=CCP44762.1;Note=Rv1991c%2C (MTCY39.28)%2C len: 114 aa. MazF6%2C toxin%2Cpart of toxin-antitoxin (TA) operon with Rv1991A. Some similarity to P13976|PEMK_ECOLI pemk protein (133 aa)%2CFASTA scores: opt: 113%2C E(): 0.043%2C (29.2%25 identity in 113 aa overlap)%3B and P96622|YDCE protein from Bacillus subtilis (116 aa)%2C FASTA scores: opt: 227%2C E(): 6.9e-09%2C (37.4%25 identity in 115 aa overlap). Also similar to Mycobacterium tuberculosis Rv2801c%2C and Rv0659c. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mazF6;locus_tag=Rv1991c;product=Toxin MazF6;protein_id=CCP44762.1;transl_table=11
AL123456.3	EMBL	gene	2234643	2234891	.	-	.	ID=gene-Rv1991A;Name=mazE6;gbkey=Gene;gene=mazE6;gene_biotype=protein_coding;locus_tag=Rv1991A
AL123456.3	EMBL	CDS	2234643	2234891	.	-	0	ID=cds-CCP44763.1;Parent=gene-Rv1991A;Dbxref=EnsemblGenomes-Gn:Rv1991A,EnsemblGenomes-Tr:CCP44763,GOA:P9WJ87,InterPro:IPR002145,InterPro:IPR010985,NCBI_GP:CCP44763.1;Name=CCP44763.1;Note=Rv1991A%2C len: 82 aa. MazE6%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv1991c. Similar to ChpI of L. interrogans%2C FASTA scores: opt: 134%2C E(): 0.024%2C29.762%25 identity (65.476%25 similar) in 84 aa overlap. Note that Pandey and Gerdes%2C 2005 predicts a different N-terminus%2C adding 10 amino acids.;gbkey=CDS;gene=mazE6;locus_tag=Rv1991A;product=Antitoxin MazE6;protein_id=CCP44763.1;transl_table=11
AL123456.3	EMBL	gene	2234991	2237306	.	-	.	ID=gene-Rv1992c;Name=ctpG;gbkey=Gene;gene=ctpG;gene_biotype=protein_coding;gene_synonym=cmtA;locus_tag=Rv1992c
AL123456.3	EMBL	CDS	2234991	2237306	.	-	0	ID=cds-CCP44764.1;Parent=gene-Rv1992c;Dbxref=EnsemblGenomes-Gn:Rv1992c,EnsemblGenomes-Tr:CCP44764,GOA:P9WPS7,InterPro:IPR001757,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,InterPro:IPR027256,NCBI_GP:CCP44764.1;Name=CCP44764.1;Note=Rv1992c%2C (MTCY39.27)%2C len: 771 aa. Probable ctpG%2Cmetal cation-transporting P-type ATPase G (transmembrane protein)%2C similar to others%2C especially cadmium-transporting ATPases%2C e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa)%3B P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa)%3B BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa)%3B 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV putative cation transporter P-type ATPase V (770 aa)%3B Rv1469%3B Rv0092%3B etc. Contains PS00435 Peroxidases proximal heme-ligand signature and PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases)%2C subfamily IB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpG;inference=protein motif:PROSITE:PS00435;locus_tag=Rv1992c;product=Probable metal cation transporter P-type ATPase G CtpG;protein_id=CCP44764.1;transl_table=11
AL123456.3	EMBL	gene	2237303	2237575	.	-	.	ID=gene-Rv1993c;Name=Rv1993c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1993c
AL123456.3	EMBL	CDS	2237303	2237575	.	-	0	ID=cds-CCP44765.1;Parent=gene-Rv1993c;Dbxref=EnsemblGenomes-Gn:Rv1993c,EnsemblGenomes-Tr:CCP44765,GOA:P9WLP5,InterPro:IPR009963,NCBI_GP:CCP44765.1;Name=CCP44765.1;Note=Rv1993c%2C (MTCY39.26)%2C len: 90 aa. Conserved protein%2Cvery similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa)%2C FASTA results: opt: 309%2C E(): 3.2e-16%2C (63.3%25 identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1%25 identity in 94 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1993c;product=Conserved protein;protein_id=CCP44765.1;transl_table=11
AL123456.3	EMBL	gene	2237628	2237984	.	-	.	ID=gene-Rv1994c;Name=cmtR;gbkey=Gene;gene=cmtR;gene_biotype=protein_coding;locus_tag=Rv1994c
AL123456.3	EMBL	CDS	2237628	2237984	.	-	0	ID=cds-CCP44766.1;Parent=gene-Rv1994c;Dbxref=EnsemblGenomes-Gn:Rv1994c,EnsemblGenomes-Tr:CCP44766,GOA:P9WMI9,InterPro:IPR001845,InterPro:IPR011991,PDB:2JSC,NCBI_GP:CCP44766.1;Name=CCP44766.1;Note=Rv1994c%2C (MTCY39.25)%2C len: 118 aa. CmtR%2Ctranscriptional regulator (See Cavet et al.%2C 2003). Similar to MERR_STRLI|P30346 probable mercury resistance operon repressor (125 aa)%2C FASTA scores: opt: 199%2C E(): 3e-08%2C(36.3%25 identity in 102 aa overlap). Note that primer extension analysis revealed two transcriptional start sites (See Chauhan et al.%2C 2009).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cmtR;locus_tag=Rv1994c;product=Metal sensor transcriptional regulator CmtR (ArsR-SmtB family);protein_id=CCP44766.1;transl_table=11
AL123456.3	EMBL	gene	2238141	2238908	.	+	.	ID=gene-Rv1995;Name=Rv1995;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1995
AL123456.3	EMBL	CDS	2238141	2238908	.	+	0	ID=cds-CCP44767.1;Parent=gene-Rv1995;Dbxref=EnsemblGenomes-Gn:Rv1995,EnsemblGenomes-Tr:CCP44767,GOA:P9WLP3,InterPro:IPR012312,NCBI_GP:CCP44767.1;Name=CCP44767.1;Note=Rv1995%2C (MTCY39.24c)%2C len: 255 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1995;product=Unknown protein;protein_id=CCP44767.1;transl_table=11
AL123456.3	EMBL	gene	2239004	2239957	.	+	.	ID=gene-Rv1996;Name=Rv1996;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1996
AL123456.3	EMBL	CDS	2239004	2239957	.	+	0	ID=cds-CCP44768.1;Parent=gene-Rv1996;Dbxref=EnsemblGenomes-Gn:Rv1996,EnsemblGenomes-Tr:CCP44768,GOA:P9WLP1,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,NCBI_GP:CCP44768.1;Name=CCP44768.1;Note=Rv1996%2C (MTCY39.23c)%2C len: 317 aa. Universal stress protein family protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv2005c|Q10851|YK05_MYCTU (295 aa)%2C FASTA scores: opt: 775%2CE(): 0%2C (50.3%25 identity in 316 aa overlap)%3B Rv2026c (294 aa) (47.9%25 identity in 311 aa overlap)%3B and Rv2623%2C etc. Also similar to SCJ1.30c|AL109962 hypothetical protein from Streptomyces coelicolor (328 aa). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1996;product=Universal stress protein family protein;protein_id=CCP44768.1;transl_table=11
AL123456.3	EMBL	gene	2240159	2242876	.	+	.	ID=gene-Rv1997;Name=ctpF;gbkey=Gene;gene=ctpF;gene_biotype=protein_coding;locus_tag=Rv1997
AL123456.3	EMBL	CDS	2240159	2242876	.	+	0	ID=cds-CCP44769.1;Parent=gene-Rv1997;Dbxref=EnsemblGenomes-Gn:Rv1997,EnsemblGenomes-Tr:CCP44769,GOA:P9WPS9,InterPro:IPR001757,InterPro:IPR004014,InterPro:IPR006068,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023298,InterPro:IPR023299,NCBI_GP:CCP44769.1;Name=CCP44769.1;Note=Rv1997%2C (MTCY39.22c%2C MTCY39.21c)%2C len: 905 aa. Probable ctpF%2C metal cation-transporting P-type ATPase F (transmembrane protein)%2C highly similar to others e.g. NP_250120.1|NC_002516 probable cation-transporting P-type ATPase from Pseudomonas aeruginosa (902 aa)%3B NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (905 aa)%3B NP_404093.1|NC_003143 putative cation-transporting P-type ATPase from Yersinia pestis (908 aa)%3B P37367|ATA1_SYNY3 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa)%2C FASTA scores: opt: 2392%2C E(): 0%2C (46.5%25 identity in 852 aa overlap)%3B etc. Contains PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases)%2C subfamily IB. Was frame-shifted in original cosmid sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpF;inference=protein motif:PROSITE:PS00154;locus_tag=Rv1997;product=Probable metal cation transporter P-type ATPase A CtpF;protein_id=CCP44769.1;transl_table=11
AL123456.3	EMBL	gene	2242945	2243721	.	-	.	ID=gene-Rv1998c;Name=Rv1998c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1998c
AL123456.3	EMBL	CDS	2242945	2243721	.	-	0	ID=cds-CCP44770.1;Parent=gene-Rv1998c;Dbxref=EnsemblGenomes-Gn:Rv1998c,EnsemblGenomes-Tr:CCP44770,GOA:P9WLN9,InterPro:IPR015813,NCBI_GP:CCP44770.1;Name=CCP44770.1;Note=Rv1998c%2C (MTCY39.20)%2C len: 258 aa. Conserved protein%2C showing some similarity with other hypothetical proteins e.g. U82823|SEU82823.03 Saccharopolyspora erythraea (266 aa)%2C FASTA results: opt: 654%2C E(): 0%2C (43.8%25 identity in 249 aa overlap)%3B and AL034446|SC1A9.07 Streptomyces coelicolor (251 aa)%2C FASTA scores: opt: 592%2CE(): 1.5e-31%2C (43.4%25 identity in 251 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv1998c;product=Conserved protein;protein_id=CCP44770.1;transl_table=11
AL123456.3	EMBL	gene	2243816	2245138	.	-	.	ID=gene-Rv1999c;Name=Rv1999c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv1999c
AL123456.3	EMBL	CDS	2243816	2245138	.	-	0	ID=cds-CCP44771.1;Parent=gene-Rv1999c;Dbxref=EnsemblGenomes-Gn:Rv1999c,EnsemblGenomes-Tr:CCP44771,GOA:P9WQM3,InterPro:IPR002293,NCBI_GP:CCP44771.1;Name=CCP44771.1;Note=Rv1999c%2C (MTCY39.19)%2C len: 440 aa. Probable conserved integral membrane protein%2C possibly transporter of cationic amino acid%2C similar to many transporters%2Cespecially amino acid transporters%2C e.g. CAC08265.1|AL392146 putative amino acid transporter from Streptomyces coelicolor (414 aa)%3B P39277|YJEH_ECOLI hypothetical 44.8 kDa protein from Escherichia coli (418 aa)%2C FASTA scores%2C opt: 343%2C E(): 6.6e-15%2C (27.2%25 identity in 408 aa overlap)%3B etc. Also similar to Rv1979c from Mycobacterium tuberculosis%2C FASTA score: (28.2%25 identity in 277 aa overlap)%3B Rv2127%2C Rv0346c%2C Rv0522%2C etc. Seems to belong to the APC family.;gbkey=CDS;locus_tag=Rv1999c;product=Probable conserved integral membrane protein;protein_id=CCP44771.1;transl_table=11
AL123456.3	EMBL	gene	2245209	2246822	.	+	.	ID=gene-Rv2000;Name=Rv2000;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2000
AL123456.3	EMBL	CDS	2245209	2246822	.	+	0	ID=cds-CCP44772.1;Parent=gene-Rv2000;Dbxref=EnsemblGenomes-Gn:Rv2000,EnsemblGenomes-Tr:CCP44772,GOA:P9WLN7,NCBI_GP:CCP44772.1;Name=CCP44772.1;Note=Rv2000%2C (MTCY39.18c)%2C len: 537 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2000;product=Unknown protein;protein_id=CCP44772.1;transl_table=11
AL123456.3	EMBL	gene	2246832	2247584	.	+	.	ID=gene-Rv2001;Name=Rv2001;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2001
AL123456.3	EMBL	CDS	2246832	2247584	.	+	0	ID=cds-CCP44773.1;Parent=gene-Rv2001;Dbxref=EnsemblGenomes-Gn:Rv2001,EnsemblGenomes-Tr:CCP44773,GOA:P9WLN5,InterPro:IPR002864,InterPro:IPR029069,NCBI_GP:CCP44773.1;Name=CCP44773.1;Note=Rv2001%2C (MTCY39.17c)%2C len: 250 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0466.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2001;product=Conserved hypothetical protein;protein_id=CCP44773.1;transl_table=11
AL123456.3	EMBL	gene	2247660	2248442	.	+	.	ID=gene-Rv2002;Name=fabG3;gbkey=Gene;gene=fabG3;gene_biotype=protein_coding;locus_tag=Rv2002
AL123456.3	EMBL	CDS	2247660	2248442	.	+	0	ID=cds-CCP44774.1;Parent=gene-Rv2002;Dbxref=EnsemblGenomes-Gn:Rv2002,EnsemblGenomes-Tr:CCP44774,GOA:P9WGT1,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,PDB:1NFF,PDB:1NFQ,PDB:1NFR,NCBI_GP:CCP44774.1;Name=CCP44774.1;Note=Rv2002%2C (MTCY39.16c)%2C len: 260 aa. FabG3%2C20-beta-hydroxysteroid dehydrogenase. Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fabG3;inference=protein motif:PROSITE:PS00061;locus_tag=Rv2002;product=Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase);protein_id=CCP44774.1;transl_table=11
AL123456.3	EMBL	gene	2248563	2249420	.	-	.	ID=gene-Rv2003c;Name=Rv2003c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2003c
AL123456.3	EMBL	CDS	2248563	2249420	.	-	0	ID=cds-CCP44775.1;Parent=gene-Rv2003c;Dbxref=EnsemblGenomes-Gn:Rv2003c,EnsemblGenomes-Tr:CCP44775,GOA:P9WJZ5,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP44775.1;Name=CCP44775.1;Note=Rv2003c%2C (MTCY39.14)%2C len: 285 aa. Conserved hypothetical protein.;gbkey=CDS;locus_tag=Rv2003c;product=Conserved hypothetical protein;protein_id=CCP44775.1;transl_table=11
AL123456.3	EMBL	gene	2249478	2250974	.	-	.	ID=gene-Rv2004c;Name=Rv2004c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2004c
AL123456.3	EMBL	CDS	2249478	2250974	.	-	0	ID=cds-CCP44776.1;Parent=gene-Rv2004c;Dbxref=EnsemblGenomes-Gn:Rv2004c,EnsemblGenomes-Tr:CCP44776,GOA:P9WLN3,InterPro:IPR011009,InterPro:IPR027417,NCBI_GP:CCP44776.1;Name=CCP44776.1;Note=Rv2004c%2C (MTCY39.13)%2C len: 498 aa. Conserved protein. Contains PS00017 ATP/GTP-binding site motif A.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2004c;product=Conserved protein;protein_id=CCP44776.1;transl_table=11
AL123456.3	EMBL	gene	2250996	2251883	.	-	.	ID=gene-Rv2005c;Name=Rv2005c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2005c
AL123456.3	EMBL	CDS	2250996	2251883	.	-	0	ID=cds-CCP44777.1;Parent=gene-Rv2005c;Dbxref=EnsemblGenomes-Gn:Rv2005c,EnsemblGenomes-Tr:CCP44777,GOA:P9WLN1,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,NCBI_GP:CCP44777.1;Name=CCP44777.1;Note=Rv2005c%2C (MTCY39.12)%2C len: 295 aa. Universal stress protein family protein. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2005c;product=Universal stress protein family protein;protein_id=CCP44777.1;transl_table=11
AL123456.3	EMBL	gene	2252002	2255985	.	+	.	ID=gene-Rv2006;Name=otsB1;gbkey=Gene;gene=otsB1;gene_biotype=protein_coding;gene_synonym=otsB;locus_tag=Rv2006
AL123456.3	EMBL	CDS	2252002	2255985	.	+	0	ID=cds-CCP44778.1;Parent=gene-Rv2006;Dbxref=EnsemblGenomes-Gn:Rv2006,EnsemblGenomes-Tr:CCP44778,GOA:P9WN15,InterPro:IPR003337,InterPro:IPR005194,InterPro:IPR005195,InterPro:IPR005196,InterPro:IPR006379,InterPro:IPR008928,InterPro:IPR011013,InterPro:IPR012341,InterPro:IPR023214,NCBI_GP:CCP44778.1;Name=CCP44778.1;Note=Rv2006%2C (MTCY39.11c)%2C len: 1327 aa. OtsB1%2Ctrehalose-6-phosphate phosphatase (see citations below). Belongs to Glycosyl hydrolases family 65. Note that previously known as otsB. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=otsB1;inference=protein motif:PROSITE:PS00148;locus_tag=Rv2006;product=Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP);protein_id=CCP44778.1;transl_table=11
AL123456.3	EMBL	gene	2256084	2256428	.	-	.	ID=gene-Rv2007c;Name=fdxA;gbkey=Gene;gene=fdxA;gene_biotype=protein_coding;locus_tag=Rv2007c
AL123456.3	EMBL	CDS	2256084	2256428	.	-	0	ID=cds-CCP44779.1;Parent=gene-Rv2007c;Dbxref=EnsemblGenomes-Gn:Rv2007c,EnsemblGenomes-Tr:CCP44779,GOA:P9WNE7,InterPro:IPR000813,InterPro:IPR001450,InterPro:IPR017896,NCBI_GP:CCP44779.1;Name=CCP44779.1;Note=Rv2007c%2C (MTCY39.10)%2C len: 114 aa. FdxA%2C ferredoxin%2Csimilar to many e.g. FER_MYCSM P00215 ferredoxin%2CMycobacterium smegmatis (106 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fdxA;locus_tag=Rv2007c;product=Ferredoxin FdxA;protein_id=CCP44779.1;transl_table=11
AL123456.3	EMBL	gene	2256617	2257942	.	-	.	ID=gene-Rv2008c;Name=Rv2008c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2008c
AL123456.3	EMBL	CDS	2256617	2257942	.	-	0	ID=cds-CCP44780.1;Parent=gene-Rv2008c;Dbxref=EnsemblGenomes-Gn:Rv2008c,EnsemblGenomes-Tr:CCP44780,GOA:P9WLM9,InterPro:IPR025420,InterPro:IPR027417,NCBI_GP:CCP44780.1;Name=CCP44780.1;Note=Rv2008c%2C (MTCY39.09)%2C len: 441 aa. Conserved hypothetical protein. Contains PS00017 ATP/GTP-binding site motif A%2C PS00501 Signal peptidases I serine active site. Also contains helix-turn-helix motif at aa 258-279.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00501;locus_tag=Rv2008c;product=Conserved hypothetical protein;protein_id=CCP44780.1;transl_table=11
AL123456.3	EMBL	gene	2258030	2258272	.	+	.	ID=gene-Rv2009;Name=vapB15;gbkey=Gene;gene=vapB15;gene_biotype=protein_coding;locus_tag=Rv2009
AL123456.3	EMBL	CDS	2258030	2258272	.	+	0	ID=cds-CCP44781.1;Parent=gene-Rv2009;Dbxref=EnsemblGenomes-Gn:Rv2009,EnsemblGenomes-Tr:CCP44781,GOA:P9WLM7,InterPro:IPR019239,NCBI_GP:CCP44781.1;Name=CCP44781.1;Note=Rv2009%2C (MTCY39.08c)%2C len: 80 aa. VapB15%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv2010 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005).;gbkey=CDS;gene=vapB15;locus_tag=Rv2009;product=Antitoxin VapB15;protein_id=CCP44781.1;transl_table=11
AL123456.3	EMBL	gene	2258273	2258671	.	+	.	ID=gene-Rv2010;Name=vapC15;gbkey=Gene;gene=vapC15;gene_biotype=protein_coding;locus_tag=Rv2010
AL123456.3	EMBL	CDS	2258273	2258671	.	+	0	ID=cds-CCP44782.1;Parent=gene-Rv2010;Dbxref=EnsemblGenomes-Gn:Rv2010,EnsemblGenomes-Tr:CCP44782,GOA:P9WF97,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44782.1;Name=CCP44782.1;Note=Rv2010%2C (MTCY39.07c)%2C len: 132 aa. VapC15%2C toxin%2Cpart of toxin-antitoxin (TA) operon with Rv2009%2C contains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C2005).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC15;locus_tag=Rv2010;product=Toxin VapC15;protein_id=CCP44782.1;transl_table=11
AL123456.3	EMBL	gene	2258854	2259285	.	-	.	ID=gene-Rv2011c;Name=Rv2011c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2011c
AL123456.3	EMBL	CDS	2258854	2259285	.	-	0	ID=cds-CCP44783.1;Parent=gene-Rv2011c;Dbxref=EnsemblGenomes-Gn:Rv2011c,EnsemblGenomes-Tr:CCP44783,InterPro:IPR011991,NCBI_GP:CCP44783.1;Name=CCP44783.1;Note=Rv2011c%2C (MTCY39.06)%2C len: 143 aa. Conserved hypothetical protein%2C probable transcription repressor. Contains IPR011991 Winged helix-turn-helix transcription repressor DNA-binding domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2011c;product=Conserved hypothetical protein%2C probable transcription repressor.;protein_id=CCP44783.1;transl_table=11
AL123456.3	EMBL	gene	2259326	2259820	.	+	.	ID=gene-Rv2012;Name=Rv2012;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2012
AL123456.3	EMBL	CDS	2259326	2259820	.	+	0	ID=cds-CCP44784.1;Parent=gene-Rv2012;Dbxref=EnsemblGenomes-Gn:Rv2012,EnsemblGenomes-Tr:CCP44784,InterPro:IPR009833,NCBI_GP:CCP44784.1;Name=CCP44784.1;Note=Rv2012%2C (MTCY39.05c)%2C len: 164 aa. Conserved hypothetical protein.;gbkey=CDS;locus_tag=Rv2012;product=Conserved hypothetical protein;protein_id=CCP44784.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2260443	2261670	.	+	.	ID=id-AL123456.3:2260443..2261670;Note=IS1607%2C len: 1228 nt. Vestigial Insertion sequence element%2C IS1607.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1607
AL123456.3	EMBL	gene	2260665	2261144	.	+	.	ID=gene-Rv2013;Name=Rv2013;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2013
AL123456.3	EMBL	CDS	2260665	2261144	.	+	0	ID=cds-CCP44785.1;Parent=gene-Rv2013;Dbxref=EnsemblGenomes-Gn:Rv2013,EnsemblGenomes-Tr:CCP44785,GOA:Q10844,InterPro:IPR002525,UniProtKB/TrEMBL:Q10844,NCBI_GP:CCP44785.1;Name=CCP44785.1;Note=Rv2013%2C (MTCY39.04c)%2C len: 159 aa. Transposase%2Cshows similarity to N-terminal part of transposase and insertion element hypothetical proteins. Length changed since first submission (no clear start apparent).;gbkey=CDS;locus_tag=Rv2013;product=Transposase;protein_id=CCP44785.1;transl_table=11
AL123456.3	EMBL	gene	2261098	2261688	.	+	.	ID=gene-Rv2014;Name=Rv2014;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2014
AL123456.3	EMBL	CDS	2261098	2261688	.	+	0	ID=cds-CCP44786.1;Parent=gene-Rv2014;Dbxref=EnsemblGenomes-Gn:Rv2014,EnsemblGenomes-Tr:CCP44786,GOA:Q10843,InterPro:IPR003346,UniProtKB/TrEMBL:Q10843,NCBI_GP:CCP44786.1;Name=CCP44786.1;Note=Rv2014%2C (MTCY39.03c)%2C len: 196 aa. Transposase%2Csimilar to insertion elements%3B possibly made by frameshifting with respect to Rv2013. Length changed since first submission.;gbkey=CDS;locus_tag=Rv2014;product=Transposase;protein_id=CCP44786.1;transl_table=11
AL123456.3	EMBL	gene	2261816	2263072	.	-	.	ID=gene-Rv2015c;Name=Rv2015c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2015c
AL123456.3	EMBL	CDS	2261816	2263072	.	-	0	ID=cds-CCP44787.1;Parent=gene-Rv2015c;Dbxref=EnsemblGenomes-Gn:Rv2015c,EnsemblGenomes-Tr:CCP44787,GOA:O53461,InterPro:IPR002711,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:O53461,NCBI_GP:CCP44787.1;Name=CCP44787.1;Note=Rv2015c%2C (MTV018.02c)%2C len: 418 aa. Conserved hypothetical protein. Nearly identical to Mycobacterium tuberculosis Rv1765c|MTCY28.31c%2C (378 aa)%2C an ORF starting next to ISB9%2C and ending in IS6110. Different N-terminus chosen and C-terminus differs as that of Rv1765c has been truncated by IS6110. Does not show similarities with transposases. Contains IPR002711 HNH endonuclease%2CIPR003615 HNH nuclease%2C IPR003870 DUF222 domains.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2015c;product=Conserved hypothetical protein;protein_id=CCP44787.1;transl_table=11
AL123456.3	EMBL	gene	2263426	2264001	.	+	.	ID=gene-Rv2016;Name=Rv2016;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2016
AL123456.3	EMBL	CDS	2263426	2264001	.	+	0	ID=cds-CCP44788.1;Parent=gene-Rv2016;Dbxref=EnsemblGenomes-Gn:Rv2016,EnsemblGenomes-Tr:CCP44788,UniProtKB/TrEMBL:O53462,NCBI_GP:CCP44788.1;Name=CCP44788.1;Note=Rv2016%2C (MTV018.03)%2C len: 191 aa. Hypothetical protein.;gbkey=CDS;locus_tag=Rv2016;product=Hypothetical protein;protein_id=CCP44788.1;transl_table=11
AL123456.3	EMBL	gene	2263998	2265038	.	+	.	ID=gene-Rv2017;Name=Rv2017;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2017
AL123456.3	EMBL	CDS	2263998	2265038	.	+	0	ID=cds-CCP44789.1;Parent=gene-Rv2017;Dbxref=EnsemblGenomes-Gn:Rv2017,EnsemblGenomes-Tr:CCP44789,GOA:O53463,InterPro:IPR001387,InterPro:IPR010359,InterPro:IPR010982,UniProtKB/TrEMBL:O53463,NCBI_GP:CCP44789.1;Name=CCP44789.1;Note=Rv2017%2C (MTV018.04)%2C len: 346 aa. Transcriptional regulator. Contains PS00142 Neutral zinc metallopeptidases%2Czinc-binding region signature in C-terminal half%2C may be fortuitous. Contains probable helix-turn-helix motif at aa 18-39 (Score 2243%2C +6.83 SD)%3B IPR001387 Helix-turn-helix type 3.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv2017;product=Transcriptional regulatory protein;protein_id=CCP44789.1;transl_table=11
AL123456.3	EMBL	gene	2265280	2265999	.	+	.	ID=gene-Rv2018;Name=Rv2018;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2018
AL123456.3	EMBL	CDS	2265280	2265999	.	+	0	ID=cds-CCP44790.1;Parent=gene-Rv2018;Dbxref=EnsemblGenomes-Gn:Rv2018,EnsemblGenomes-Tr:CCP44790,GOA:O53464,InterPro:IPR007367,InterPro:IPR009057,InterPro:IPR011991,InterPro:IPR017277,UniProtKB/TrEMBL:O53464,NCBI_GP:CCP44790.1;Name=CCP44790.1;Note=Rv2018%2C (MTV018.05)%2C len: 239 aa. Conserved protein. Contains probable helix-turn-helix motif at aa 215-236 (Score 1175%2C +3.19 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2018;product=Conserved protein;protein_id=CCP44790.1;transl_table=11
AL123456.3	EMBL	gene	2265989	2266405	.	+	.	ID=gene-Rv2019;Name=Rv2019;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2019
AL123456.3	EMBL	CDS	2265989	2266405	.	+	0	ID=cds-CCP44791.1;Parent=gene-Rv2019;Dbxref=EnsemblGenomes-Gn:Rv2019,EnsemblGenomes-Tr:CCP44791,UniProtKB/TrEMBL:O53465,NCBI_GP:CCP44791.1;Name=CCP44791.1;Note=Rv2019%2C (MTV018.06)%2C len: 138 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2019;product=Conserved protein;protein_id=CCP44791.1;transl_table=11
AL123456.3	EMBL	gene	2266421	2266720	.	-	.	ID=gene-Rv2020c;Name=Rv2020c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2020c
AL123456.3	EMBL	CDS	2266421	2266720	.	-	0	ID=cds-CCP44792.1;Parent=gene-Rv2020c;Dbxref=EnsemblGenomes-Gn:Rv2020c,EnsemblGenomes-Tr:CCP44792,UniProtKB/TrEMBL:O53466,NCBI_GP:CCP44792.1;Name=CCP44792.1;Note=Rv2020c%2C (MTV018.07c)%2C len: 99 aa. Conserved hypothetical protein%2C nearly identical to C-terminal part of hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds to deletion region RvD1 so probably truncated protein.;gbkey=CDS;locus_tag=Rv2020c;product=Conserved hypothetical protein;protein_id=CCP44792.1;transl_table=11
AL123456.3	EMBL	gene	2266805	2267110	.	-	.	ID=gene-Rv2021c;Name=Rv2021c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2021c
AL123456.3	EMBL	CDS	2266805	2267110	.	-	0	ID=cds-CCP44793.1;Parent=gene-Rv2021c;Dbxref=EnsemblGenomes-Gn:Rv2021c,EnsemblGenomes-Tr:CCP44793,GOA:O53467,InterPro:IPR001387,InterPro:IPR010982,UniProtKB/TrEMBL:O53467,NCBI_GP:CCP44793.1;Name=CCP44793.1;Note=Rv2021c%2C (MTV018.08c)%2C len: 101 aa. Regulatory protein%2C similar to many. Contains probable helix-turn-helix at aa 45-66 (Score 1472%2C +4.20 SD)%3B IPR001387 Helix-turn-helix type 3 domain.;gbkey=CDS;locus_tag=Rv2021c;product=Transcriptional regulatory protein;protein_id=CCP44793.1;transl_table=11
AL123456.3	EMBL	gene	2267119	2267724	.	-	.	ID=gene-Rv2022c;Name=Rv2022c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2022c
AL123456.3	EMBL	CDS	2267119	2267724	.	-	0	ID=cds-CCP44794.1;Parent=gene-Rv2022c;Dbxref=EnsemblGenomes-Gn:Rv2022c,EnsemblGenomes-Tr:CCP44794,InterPro:IPR009241,UniProtKB/TrEMBL:O53468,NCBI_GP:CCP44794.1;Name=CCP44794.1;Note=Rv2022c%2C (MTV018.09c)%2C len: 201 aa. Conserved protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2022c;product=Conserved protein;protein_id=CCP44794.1;transl_table=11
AL123456.3	EMBL	gene	2267749	2268108	.	-	.	ID=gene-Rv2023c;Name=Rv2023c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2023c
AL123456.3	EMBL	CDS	2267749	2268108	.	-	0	ID=cds-CCP44795.1;Parent=gene-Rv2023c;Dbxref=EnsemblGenomes-Gn:Rv2023c,EnsemblGenomes-Tr:CCP44795,UniProtKB/TrEMBL:O53469,NCBI_GP:CCP44795.1;Name=CCP44795.1;Note=Rv2023c%2C (MTV018.10c)%2C len: 119 aa. Hypothetical protein%2C alternative upstream start possible.;gbkey=CDS;locus_tag=Rv2023c;product=Hypothetical protein;protein_id=CCP44795.1;transl_table=11
AL123456.3	EMBL	pseudogene	2268268	2268726	.	-	.	ID=gene-Rv2023A;Name=Rv2023A;gbkey=Gene;gene_biotype=pseudogene;locus_tag=Rv2023A;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	2268268	2268726	.	-	0	ID=cds-Rv2023A;Parent=gene-Rv2023A;Dbxref=PSEUDO:CCP44796.1;Note=Rv2023A%2C len: 152 aa. Hypothetical unknown protein (pseudogene)%2C equivalent to the C-terminus of Q8VJS0|MT2080 hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (225 aa)%2C FASTA scores: opt: 1028%2C E(): 3.6e-66%2C(99.342%25 identity in 152 aa overlap) and C-terminus of Mb2047c hypothetical protein from Mycobacterium bovis (225 aa). And N-terminal part equivalent to the C-terminus of Q9XB17 hypothetical 15.5 kDa protein from Mycobacterium bovis BCG (131 aa)%2C FASTA scores: opt: 409%2C E(): 4.2e-22%2C(98.276%25 identity in 58 aa overlap). Note that a deletion of DNA (RvD1 region) in Mycobacterium tuberculosis strain H37Rv resulted in a truncated CDS comparatively to Mycobacterium bovis or Mycobacterium tuberculosis strain CDC1551 genomes (see citations below).;gbkey=CDS;locus_tag=Rv2023A;product=Hypothetical protein%2C pseudogene;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	2268693	2270240	.	-	.	ID=gene-Rv2024c;Name=Rv2024c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2024c
AL123456.3	EMBL	CDS	2268693	2270240	.	-	0	ID=cds-CCP44797.1;Parent=gene-Rv2024c;Dbxref=EnsemblGenomes-Gn:Rv2024c,EnsemblGenomes-Tr:CCP44797,GOA:O53470,InterPro:IPR006935,InterPro:IPR011335,InterPro:IPR011856,InterPro:IPR014001,InterPro:IPR027417,UniProtKB/TrEMBL:O53470,NCBI_GP:CCP44797.1;Name=CCP44797.1;Note=Rv2024c%2C (MTV018.11c)%2C len: 515 aa. Conserved hypothetical protein. Identical to N-terminal part of much larger hypothetical protein%2C RvD1-Rv2024c' (1606 aa)%2C from Mycobacterium bovis BCG: CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably truncated. Part of RvD1 chromosomal deletion region.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2024c;product=Conserved hypothetical protein;protein_id=CCP44797.1;transl_table=11
AL123456.3	EMBL	gene	2270750	2271748	.	-	.	ID=gene-Rv2025c;Name=Rv2025c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2025c
AL123456.3	EMBL	CDS	2270750	2271748	.	-	0	ID=cds-CCP44798.1;Parent=gene-Rv2025c;Dbxref=EnsemblGenomes-Gn:Rv2025c,EnsemblGenomes-Tr:CCP44798,GOA:P9WGF5,InterPro:IPR002524,InterPro:IPR027469,InterPro:IPR027470,NCBI_GP:CCP44798.1;Name=CCP44798.1;Note=Rv2025c%2C (MTV018.12c)%2C len: 332 aa. Conserved transmembrane protein%2C involved in transport of metal ions%2Ccontains IPR002524 Cation efflux protein domain.;gbkey=CDS;locus_tag=Rv2025c;product=Conserved membrane protein;protein_id=CCP44798.1;transl_table=11
AL123456.3	EMBL	gene	2271863	2272747	.	-	.	ID=gene-Rv2026c;Name=Rv2026c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2026c
AL123456.3	EMBL	CDS	2271863	2272747	.	-	0	ID=cds-CCP44799.1;Parent=gene-Rv2026c;Dbxref=EnsemblGenomes-Gn:Rv2026c,EnsemblGenomes-Tr:CCP44799,GOA:P9WFD1,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,NCBI_GP:CCP44799.1;Name=CCP44799.1;Note=Rv2026c%2C (MTV018.13c)%2C len: 294 aa. Universal stress protein family protein%2C contains IPR006016 UspA domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2026c;product=Universal stress protein family protein;protein_id=CCP44799.1;transl_table=11
AL123456.3	EMBL	gene	2272787	2274508	.	-	.	ID=gene-Rv2027c;Name=dosT;gbkey=Gene;gene=dosT;gene_biotype=protein_coding;locus_tag=Rv2027c
AL123456.3	EMBL	CDS	2272787	2274508	.	-	0	ID=cds-CCP44800.1;Parent=gene-Rv2027c;Dbxref=EnsemblGenomes-Gn:Rv2027c,EnsemblGenomes-Tr:CCP44800,GOA:P9WGK1,InterPro:IPR003018,InterPro:IPR003594,InterPro:IPR011712,InterPro:IPR027035,InterPro:IPR029016,PDB:2VZW,PDB:3ZXQ,NCBI_GP:CCP44800.1;Name=CCP44800.1;Note=Rv2027c%2C (MTV018.14c)%2C len: 573 aa. DosT%2C Histidine kinase response regulator%2C highly similar to others.;gbkey=CDS;gene=dosT;locus_tag=Rv2027c;product=Two component sensor histidine kinase DosT;protein_id=CCP44800.1;transl_table=11
AL123456.3	EMBL	gene	2274569	2275408	.	-	.	ID=gene-Rv2028c;Name=Rv2028c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2028c
AL123456.3	EMBL	CDS	2274569	2275408	.	-	0	ID=cds-CCP44801.1;Parent=gene-Rv2028c;Dbxref=EnsemblGenomes-Gn:Rv2028c,EnsemblGenomes-Tr:CCP44801,GOA:P9WFD9,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,NCBI_GP:CCP44801.1;Name=CCP44801.1;Note=Rv2028c%2C (MTV018.15c)%2C len: 279 aa. Universal stress protein family protein%2C highly similar to many%2C contains IPR006016 UspA domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2028c;product=Universal stress protein family protein;protein_id=CCP44801.1;transl_table=11
AL123456.3	EMBL	gene	2275405	2276424	.	-	.	ID=gene-Rv2029c;Name=pfkB;gbkey=Gene;gene=pfkB;gene_biotype=protein_coding;locus_tag=Rv2029c
AL123456.3	EMBL	CDS	2275405	2276424	.	-	0	ID=cds-CCP44802.1;Parent=gene-Rv2029c;Dbxref=EnsemblGenomes-Gn:Rv2029c,EnsemblGenomes-Tr:CCP44802,GOA:P9WID3,InterPro:IPR002173,InterPro:IPR011611,InterPro:IPR017583,InterPro:IPR029056,NCBI_GP:CCP44802.1;Name=CCP44802.1;Note=Rv2029c%2C (MTV018.16c)%2C len: 339 aa. PfkB%2Cphosphofructokinase. Contains PS00583 pfkB family of carbohydrate kinases signature 1. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;gbkey=CDS;gene=pfkB;inference=protein motif:PROSITE:PS00583;locus_tag=Rv2029c;product=6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase);protein_id=CCP44802.1;transl_table=11
AL123456.3	EMBL	gene	2276441	2278486	.	-	.	ID=gene-Rv2030c;Name=Rv2030c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2030c
AL123456.3	EMBL	CDS	2276441	2278486	.	-	0	ID=cds-CCP44803.1;Parent=gene-Rv2030c;Dbxref=EnsemblGenomes-Gn:Rv2030c,EnsemblGenomes-Tr:CCP44803,GOA:P9WLM1,InterPro:IPR000836,InterPro:IPR007815,InterPro:IPR029057,NCBI_GP:CCP44803.1;Name=CCP44803.1;Note=Rv2030c%2C (MTV018.17c)%2C len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2030c;product=Conserved protein;protein_id=CCP44803.1;transl_table=11
AL123456.3	EMBL	gene	2278498	2278932	.	-	.	ID=gene-Rv2031c;Name=hspX;gbkey=Gene;gene=hspX;gene_biotype=protein_coding;gene_synonym=acr;locus_tag=Rv2031c
AL123456.3	EMBL	CDS	2278498	2278932	.	-	0	ID=cds-CCP44804.1;Parent=gene-Rv2031c;Dbxref=EnsemblGenomes-Gn:Rv2031c,EnsemblGenomes-Tr:CCP44804,GOA:P9WMK1,InterPro:IPR002068,InterPro:IPR008978,NCBI_GP:CCP44804.1;Name=CCP44804.1;Note=Rv2031c%2C (MTV018.18c)%2C len: 144 aa. HspX%2C heat shock protein localized in the inner membrane (see citations below). Identical to P30223|14KD_MYCTU 14 KD antigen (16 kDa antigen) (HSP 16.3) of Mycobacterium tuberculosis (143 aa). Belongs to the small heat shock protein (HSP20) family. Also known as alpha-crystallin and gene as acr (see some citations below). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hspX;locus_tag=Rv2031c;product=Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3);protein_id=CCP44804.1;transl_table=11
AL123456.3	EMBL	gene	2279129	2280124	.	+	.	ID=gene-Rv2032;Name=acg;gbkey=Gene;gene=acg;gene_biotype=protein_coding;locus_tag=Rv2032
AL123456.3	EMBL	CDS	2279129	2280124	.	+	0	ID=cds-CCP44805.1;Parent=gene-Rv2032;Dbxref=EnsemblGenomes-Gn:Rv2032,EnsemblGenomes-Tr:CCP44805,GOA:P9WIZ9,InterPro:IPR000415,InterPro:IPR029479,NCBI_GP:CCP44805.1;Name=CCP44805.1;Note=Rv2032%2C (MTV018.19)%2C len: 331 aa. Acg (for acr-coregulated gene)%2C conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al.%2C 2002)%2C similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=acg;locus_tag=Rv2032;product=Conserved protein Acg;protein_id=CCP44805.1;transl_table=11
AL123456.3	EMBL	gene	2280240	2281082	.	-	.	ID=gene-Rv2033c;Name=Rv2033c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2033c
AL123456.3	EMBL	CDS	2280240	2281082	.	-	0	ID=cds-CCP44806.1;Parent=gene-Rv2033c;Dbxref=EnsemblGenomes-Gn:Rv2033c,EnsemblGenomes-Tr:CCP44806,GOA:O53477,InterPro:IPR021447,UniProtKB/TrEMBL:O53477,NCBI_GP:CCP44806.1;Name=CCP44806.1;Note=Rv2033c%2C (MTV018.20)%2C len: 280 aa. Conserved hypothetical protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2033c;product=Conserved hypothetical protein;protein_id=CCP44806.1;transl_table=11
AL123456.3	EMBL	gene	2281294	2281617	.	+	.	ID=gene-Rv2034;Name=Rv2034;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2034
AL123456.3	EMBL	CDS	2281294	2281617	.	+	0	ID=cds-CCP44807.1;Parent=gene-Rv2034;Dbxref=EnsemblGenomes-Gn:Rv2034,EnsemblGenomes-Tr:CCP44807,GOA:O53478,InterPro:IPR001845,InterPro:IPR011991,NCBI_GP:CCP44807.1;Name=CCP44807.1;Note=Rv2034%2C (MTV018.21)%2C len: 107 aa. Repressor protein belonging to the ArsR family. Contains probable helix-turn-helix at aa 32-53 (S core 1350%2C +3.78 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2034;product=ArsR repressor protein;protein_id=CCP44807.1;transl_table=11
AL123456.3	EMBL	gene	2281614	2282102	.	+	.	ID=gene-Rv2035;Name=Rv2035;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2035
AL123456.3	EMBL	CDS	2281614	2282102	.	+	0	ID=cds-CCP44808.1;Parent=gene-Rv2035;Dbxref=EnsemblGenomes-Gn:Rv2035,EnsemblGenomes-Tr:CCP44808,GOA:O53479,InterPro:IPR013538,InterPro:IPR023393,UniProtKB/TrEMBL:O53479,NCBI_GP:CCP44808.1;Name=CCP44808.1;Note=Rv2035%2C (MTV018.22)%2C len: 162 aa. Conserved hypothetical protein%2C similar to many. Contains IPR013538 Activator of Hsp90 ATPase homologue 1-like.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2035;product=Conserved hypothetical protein;protein_id=CCP44808.1;transl_table=11
AL123456.3	EMBL	gene	2282099	2282740	.	+	.	ID=gene-Rv2036;Name=Rv2036;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2036
AL123456.3	EMBL	CDS	2282099	2282740	.	+	0	ID=cds-CCP44809.1;Parent=gene-Rv2036;Dbxref=EnsemblGenomes-Gn:Rv2036,EnsemblGenomes-Tr:CCP44809,GOA:O53480,InterPro:IPR010872,InterPro:IPR017517,InterPro:IPR024344,InterPro:IPR027369,UniProtKB/TrEMBL:O53480,NCBI_GP:CCP44809.1;Name=CCP44809.1;Note=Rv2036%2C (MTV018.23)%2C len: 213 aa. Conserved hypothetical protein%3B similar to many.;gbkey=CDS;locus_tag=Rv2036;product=Conserved hypothetical protein;protein_id=CCP44809.1;transl_table=11
AL123456.3	EMBL	gene	2282747	2283721	.	-	.	ID=gene-Rv2037c;Name=Rv2037c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2037c
AL123456.3	EMBL	CDS	2282747	2283721	.	-	0	ID=cds-CCP44810.1;Parent=gene-Rv2037c;Dbxref=EnsemblGenomes-Gn:Rv2037c,EnsemblGenomes-Tr:CCP44810,GOA:L0TB61,InterPro:IPR002641,InterPro:IPR016035,UniProtKB/TrEMBL:L0TB61,NCBI_GP:CCP44810.1;Name=CCP44810.1;Note=Rv2037c%2C (MTV018.24c)%2C len: 324 aa. Conserved transmembrane protein%2C similar to many. Alternative nucleotide at position 2282787 (C->T%3B C312Y) has been observed. Contains IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase motif.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2037c;product=Conserved transmembrane protein;protein_id=CCP44810.1;transl_table=11
AL123456.3	EMBL	gene	2283723	2284796	.	-	.	ID=gene-Rv2038c;Name=Rv2038c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2038c
AL123456.3	EMBL	CDS	2283723	2284796	.	-	0	ID=cds-CCP44811.1;Parent=gene-Rv2038c;Dbxref=EnsemblGenomes-Gn:Rv2038c,EnsemblGenomes-Tr:CCP44811,GOA:O53482,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR008995,InterPro:IPR012340,InterPro:IPR013611,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O53482,NCBI_GP:CCP44811.1;Name=CCP44811.1;Note=Rv2038c%2C (MTV018.25c)%2C len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below)%2C similar to many. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv2038c;product=Probable sugar-transport ATP-binding protein ABC transporter;protein_id=CCP44811.1;transl_table=11
AL123456.3	EMBL	gene	2284799	2285641	.	-	.	ID=gene-Rv2039c;Name=Rv2039c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2039c
AL123456.3	EMBL	CDS	2284799	2285641	.	-	0	ID=cds-CCP44812.1;Parent=gene-Rv2039c;Dbxref=EnsemblGenomes-Gn:Rv2039c,EnsemblGenomes-Tr:CCP44812,GOA:O53483,InterPro:IPR000515,UniProtKB/TrEMBL:O53483,NCBI_GP:CCP44812.1;Name=CCP44812.1;Note=Rv2039c%2C (MTV018.26c)%2C len: 280 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below)%2C similar to many. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Also contains possible helix-turn-helix motif at aa 171-192%2C although this is probably fortuitous.;gbkey=CDS;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2039c;product=Probable sugar-transport integral membrane protein ABC transporter;protein_id=CCP44812.1;transl_table=11
AL123456.3	EMBL	gene	2285628	2286530	.	-	.	ID=gene-Rv2040c;Name=Rv2040c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2040c
AL123456.3	EMBL	CDS	2285628	2286530	.	-	0	ID=cds-CCP44813.1;Parent=gene-Rv2040c;Dbxref=EnsemblGenomes-Gn:Rv2040c,EnsemblGenomes-Tr:CCP44813,GOA:O53484,InterPro:IPR000515,UniProtKB/TrEMBL:O53484,NCBI_GP:CCP44813.1;Name=CCP44813.1;Note=Rv2040c%2C (MTV018.27c)%2C len: 300 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below)%2C similar to many.;gbkey=CDS;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2040c;product=Probable sugar-transport integral membrane protein ABC transporter;protein_id=CCP44813.1;transl_table=11
AL123456.3	EMBL	gene	2286527	2287846	.	-	.	ID=gene-Rv2041c;Name=Rv2041c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2041c
AL123456.3	EMBL	CDS	2286527	2287846	.	-	0	ID=cds-CCP44814.1;Parent=gene-Rv2041c;Dbxref=EnsemblGenomes-Gn:Rv2041c,EnsemblGenomes-Tr:CCP44814,GOA:O53485,InterPro:IPR006059,InterPro:IPR006311,UniProtKB/TrEMBL:O53485,NCBI_GP:CCP44814.1;Name=CCP44814.1;Note=Rv2041c%2C (MTV018.28c)%2C len: 439 aa. Probable sugar-binding lipoprotein component of sugar transport system%2C similar to many. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2041c;product=Probable sugar-binding lipoprotein;protein_id=CCP44814.1;transl_table=11
AL123456.3	EMBL	gene	2287884	2288681	.	-	.	ID=gene-Rv2042c;Name=Rv2042c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2042c
AL123456.3	EMBL	CDS	2287884	2288681	.	-	0	ID=cds-CCP44815.1;Parent=gene-Rv2042c;Dbxref=EnsemblGenomes-Gn:Rv2042c,EnsemblGenomes-Tr:CCP44815,GOA:O53486,InterPro:IPR002075,UniProtKB/TrEMBL:O53486,NCBI_GP:CCP44815.1;Name=CCP44815.1;Note=Rv2042c%2C (MTV018.29c)%2C len: 265 aa. Conserved protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2042c;product=Conserved protein;protein_id=CCP44815.1;transl_table=11
AL123456.3	EMBL	gene	2288681	2289241	.	-	.	ID=gene-Rv2043c;Name=pncA;gbkey=Gene;gene=pncA;gene_biotype=protein_coding;locus_tag=Rv2043c
AL123456.3	EMBL	CDS	2288681	2289241	.	-	0	ID=cds-CCP44816.1;Parent=gene-Rv2043c;Dbxref=EnsemblGenomes-Gn:Rv2043c,EnsemblGenomes-Tr:CCP44816,GOA:I6XD65,InterPro:IPR000868,UniProtKB/TrEMBL:I6XD65,NCBI_GP:CCP44816.1;Name=CCP44816.1;Note=Rv2043c%2C (MTV018.30c)%2C len: 186 aa. PncA%2Cpyrazinamidase/nicotinamidase (see citations below)%2Cinvolved in susceptibility or resistance to antituberculous drug pyrazinamide.;gbkey=CDS;gene=pncA;locus_tag=Rv2043c;product=Pyrazinamidase/nicotinamidase PncA (PZase);protein_id=CCP44816.1;transl_table=11
AL123456.3	EMBL	gene	2289282	2289599	.	-	.	ID=gene-Rv2044c;Name=Rv2044c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2044c
AL123456.3	EMBL	CDS	2289282	2289599	.	-	0	ID=cds-CCP44817.1;Parent=gene-Rv2044c;Dbxref=EnsemblGenomes-Gn:Rv2044c,EnsemblGenomes-Tr:CCP44817,InterPro:IPR021218,UniProtKB/TrEMBL:O53487,NCBI_GP:CCP44817.1;Name=CCP44817.1;Note=Rv2044c%2C (MTV018.31c)%2C len: 105 aa. Conserved hypothetical protein%2C similar to many.;gbkey=CDS;locus_tag=Rv2044c;product=Conserved hypothetical protein;protein_id=CCP44817.1;transl_table=11
AL123456.3	EMBL	gene	2289685	2291220	.	-	.	ID=gene-Rv2045c;Name=lipT;gbkey=Gene;gene=lipT;gene_biotype=protein_coding;locus_tag=Rv2045c
AL123456.3	EMBL	CDS	2289685	2291220	.	-	0	ID=cds-CCP44818.1;Parent=gene-Rv2045c;Dbxref=EnsemblGenomes-Gn:Rv2045c,EnsemblGenomes-Tr:CCP44818,GOA:O53488,InterPro:IPR002018,InterPro:IPR002168,InterPro:IPR019819,InterPro:IPR019826,InterPro:IPR029058,UniProtKB/TrEMBL:O53488,NCBI_GP:CCP44818.1;Name=CCP44818.1;Note=Rv2045c%2C (MTV018.32c)%2C len: 511 aa. LipT%2Ccarboxylesterase%2C similar to many. Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site.;gbkey=CDS;gene=lipT;inference=protein motif:PROSITE:PS00941;locus_tag=Rv2045c;product=Carboxylesterase LipT;protein_id=CCP44818.1;transl_table=11
AL123456.3	EMBL	gene	2291269	2291925	.	+	.	ID=gene-Rv2046;Name=lppI;gbkey=Gene;gene=lppI;gene_biotype=protein_coding;locus_tag=Rv2046
AL123456.3	EMBL	CDS	2291269	2291925	.	+	0	ID=cds-CCP44819.1;Parent=gene-Rv2046;Dbxref=EnsemblGenomes-Gn:Rv2046,EnsemblGenomes-Tr:CCP44819,GOA:O53489,UniProtKB/TrEMBL:O53489,NCBI_GP:CCP44819.1;Name=CCP44819.1;Note=Rv2046%2C (MTV018.33)%2C len: 218 aa. Probable lppI%2Clipoprotein contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppI;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2046;product=Probable lipoprotein LppI;protein_id=CCP44819.1;transl_table=11
AL123456.3	EMBL	gene	2291962	2294526	.	-	.	ID=gene-Rv2047c;Name=Rv2047c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2047c
AL123456.3	EMBL	CDS	2291962	2294526	.	-	0	ID=cds-CCP44820.1;Parent=gene-Rv2047c;Dbxref=EnsemblGenomes-Gn:Rv2047c,EnsemblGenomes-Tr:CCP44820,GOA:P9WIH5,InterPro:IPR008279,InterPro:IPR016040,NCBI_GP:CCP44820.1;Name=CCP44820.1;Note=Rv2047c%2C (MTV018.34c)%2C len: 854 aa. Conserved hypothetical protein%2C similar to many. Contains IPR016040 NAD(P)-binding domain at N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2047c;product=Conserved hypothetical protein;protein_id=CCP44820.1;transl_table=11
AL123456.3	EMBL	gene	2294531	2306986	.	-	.	ID=gene-Rv2048c;Name=pks12;gbkey=Gene;gene=pks12;gene_biotype=protein_coding;locus_tag=Rv2048c
AL123456.3	EMBL	CDS	2294531	2306986	.	-	0	ID=cds-CCP44821.1;Parent=gene-Rv2048c;Dbxref=EnsemblGenomes-Gn:Rv2048c,EnsemblGenomes-Tr:CCP44821,GOA:I6XD69,InterPro:IPR001227,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR013968,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR020807,InterPro:IPR020841,InterPro:IPR020842,InterPro:IPR020843,UniProtKB/TrEMBL:I6XD69,NCBI_GP:CCP44821.1;Name=CCP44821.1;Note=Rv2048c%2C (MTV018.35c)%2C len: 4151 aa. Pks12%2Cpolyketide synthase similar to many. Contains 2x PS00012 Phosphopantetheine attachment site%2C 2x PS00606 Beta-ketoacyl synthases active site%2C and PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. Nucleotide position 2297976 in the genome sequence has been corrected%2C G:A resulting in S3004L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks12;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2048c;product=Polyketide synthase Pks12;protein_id=CCP44821.1;transl_table=11
AL123456.3	EMBL	gene	2299745	2299886	.	+	.	ID=gene-ASpks;Name=ASpks;gbkey=Gene;gene=ASpks;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	2299745	2299886	.	+	.	ID=rna-ASpks;Parent=gene-ASpks;Note=ASpks%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 2299785 and 2299796. Alternate 3'-end at position 2299873. This sequence is repeated in pks12|Rv2048c at position 2305814-2305955.;gbkey=ncRNA;gene=ASpks;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	2299745	2299886	.	+	.	ID=exon-ASpks-1;Parent=rna-ASpks;Note=ASpks%2C putative small regulatory RNA (See Arnvig and Young%2C 2009). Alternate 5'-ends at positions 2299785 and 2299796. Alternate 3'-end at position 2299873. This sequence is repeated in pks12|Rv2048c at position 2305814-2305955.;gbkey=ncRNA;gene=ASpks;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	2307293	2307517	.	-	.	ID=gene-Rv2049c;Name=Rv2049c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2049c
AL123456.3	EMBL	CDS	2307293	2307517	.	-	0	ID=cds-CCP44822.1;Parent=gene-Rv2049c;Dbxref=EnsemblGenomes-Gn:Rv2049c,EnsemblGenomes-Tr:CCP44822,UniProtKB/TrEMBL:O53491,NCBI_GP:CCP44822.1;Name=CCP44822.1;Note=Rv2049c%2C (MTV018.36c)%2C len: 74 aa. Conserved hypothetical protein.;gbkey=CDS;locus_tag=Rv2049c;product=Conserved hypothetical protein;protein_id=CCP44822.1;transl_table=11
AL123456.3	EMBL	gene	2307821	2308156	.	+	.	ID=gene-Rv2050;Name=Rv2050;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2050
AL123456.3	EMBL	CDS	2307821	2308156	.	+	0	ID=cds-CCP44823.1;Parent=gene-Rv2050;Dbxref=EnsemblGenomes-Gn:Rv2050,EnsemblGenomes-Tr:CCP44823,GOA:P9WHJ5,InterPro:IPR025182,PDB:2M4V,PDB:2M6P,NCBI_GP:CCP44823.1;Name=CCP44823.1;Note=Rv2050%2C (MTV018.37)%2C len: 111 aa. Conserved protein%2Csimilar to many. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2050;product=Conserved protein;protein_id=CCP44823.1;transl_table=11
AL123456.3	EMBL	gene	2308131	2310755	.	-	.	ID=gene-Rv2051c;Name=ppm1;gbkey=Gene;gene=ppm1;gene_biotype=protein_coding;locus_tag=Rv2051c
AL123456.3	EMBL	CDS	2308131	2310755	.	-	0	ID=cds-CCP44824.1;Parent=gene-Rv2051c;Dbxref=EnsemblGenomes-Gn:Rv2051c,EnsemblGenomes-Tr:CCP44824,GOA:O53493,InterPro:IPR001173,InterPro:IPR003010,InterPro:IPR004563,InterPro:IPR029044,UniProtKB/TrEMBL:O53493,NCBI_GP:CCP44824.1;Name=CCP44824.1;Note=Rv2051c%2C (MTV018.38c)%2C len: 874 aa. Ppm1%2CPolyprenol-monophosphomannose synthase. Transfers mannose from GDP-Mannose to all endogenous polyprenol-phosphates in Mycobacterium tuberculosis%2C proven experimentally (A. Baulard%2C Institut Pasteur de Lille: see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppm1;locus_tag=Rv2051c;product=Polyprenol-monophosphomannose synthase Ppm1;protein_id=CCP44824.1;transl_table=11
AL123456.3	EMBL	gene	2310913	2312517	.	-	.	ID=gene-Rv2052c;Name=Rv2052c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2052c
AL123456.3	EMBL	CDS	2310913	2312517	.	-	0	ID=cds-CCP44825.1;Parent=gene-Rv2052c;Dbxref=EnsemblGenomes-Gn:Rv2052c,EnsemblGenomes-Tr:CCP44825,GOA:O53494,InterPro:IPR011059,InterPro:IPR013108,UniProtKB/TrEMBL:O53494,NCBI_GP:CCP44825.1;Name=CCP44825.1;Note=Rv2052c%2C (MTV018.39c)%2C len: 534 aa. Conserved protein%2C similar to many. Contains IPR013108 Amidohydrolase 3 domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2052c;product=Conserved protein;protein_id=CCP44825.1;transl_table=11
AL123456.3	EMBL	gene	2312522	2313049	.	-	.	ID=gene-Rv2053c;Name=fxsA;gbkey=Gene;gene=fxsA;gene_biotype=protein_coding;locus_tag=Rv2053c
AL123456.3	EMBL	CDS	2312522	2313049	.	-	0	ID=cds-CCP44826.1;Parent=gene-Rv2053c;Dbxref=EnsemblGenomes-Gn:Rv2053c,EnsemblGenomes-Tr:CCP44826,GOA:O53495,InterPro:IPR007313,UniProtKB/TrEMBL:O53495,NCBI_GP:CCP44826.1;Name=CCP44826.1;Note=Rv2053c%2C (MTV018.40c-MTCY63A.07)%2C len: 175 aa. Probable fxsA%2C transmembrane protein. Contains IPR007313 FxsA cytoplasmic membrane protein domain in N-terminus;gbkey=CDS;gene=fxsA;locus_tag=Rv2053c;product=Probable transmembrane protein FxsA;protein_id=CCP44826.1;transl_table=11
AL123456.3	EMBL	gene	2313125	2313838	.	+	.	ID=gene-Rv2054;Name=Rv2054;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2054
AL123456.3	EMBL	CDS	2313125	2313838	.	+	0	ID=cds-CCP44827.1;Parent=gene-Rv2054;Dbxref=EnsemblGenomes-Gn:Rv2054,EnsemblGenomes-Tr:CCP44827,GOA:O86353,InterPro:IPR002925,InterPro:IPR029058,UniProtKB/TrEMBL:O86353,NCBI_GP:CCP44827.1;Name=CCP44827.1;Note=Rv2054%2C (MTCY63A.06c)%2C len: 237 aa. Conserved protein%2C similar to many. Contains IPR002925 Dienelactone hydrolase domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2054;product=Conserved protein;protein_id=CCP44827.1;transl_table=11
AL123456.3	EMBL	gene	2314087	2314353	.	-	.	ID=gene-Rv2055c;Name=rpsR2;gbkey=Gene;gene=rpsR2;gene_biotype=protein_coding;locus_tag=Rv2055c
AL123456.3	EMBL	CDS	2314087	2314353	.	-	0	ID=cds-CCP44828.1;Parent=gene-Rv2055c;Dbxref=EnsemblGenomes-Gn:Rv2055c,EnsemblGenomes-Tr:CCP44828,GOA:P9WH47,InterPro:IPR001648,InterPro:IPR018275,NCBI_GP:CCP44828.1;Name=CCP44828.1;Note=Rv2055c%2C (MTCY63A.05)%2C len: 88 aa. rpsR2%2C 30S ribosomal protein S18%2C similar to many. Also similar to rpsR|Rv0055|MTCY21D4.18 from Mycobacterium tuberculosis (50.0%25 identity in 84 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsR2;locus_tag=Rv2055c;product=30S ribosomal protein S18 RpsR2;protein_id=CCP44828.1;transl_table=11
AL123456.3	EMBL	gene	2314354	2314659	.	-	.	ID=gene-Rv2056c;Name=rpsN2;gbkey=Gene;gene=rpsN2;gene_biotype=protein_coding;locus_tag=Rv2056c
AL123456.3	EMBL	CDS	2314354	2314659	.	-	0	ID=cds-CCP44829.1;Parent=gene-Rv2056c;Dbxref=EnsemblGenomes-Gn:Rv2056c,EnsemblGenomes-Tr:CCP44829,GOA:P9WH59,InterPro:IPR001209,InterPro:IPR023036,NCBI_GP:CCP44829.1;Name=CCP44829.1;Note=Rv2056c%2C (MTCY63A.04)%2C len: 101 aa. rpsN2%2C 30S ribosomal protein S14%2C similar to many. Also similar to rpsN|Rv0717|MTCY210.36 from Mycobacterium tuberculosis%2C(50.0%25 identity in 62 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsN2;locus_tag=Rv2056c;product=30S ribosomal protein S14 RpsN2;protein_id=CCP44829.1;transl_table=11
AL123456.3	EMBL	gene	2314661	2314825	.	-	.	ID=gene-Rv2057c;Name=rpmG1;gbkey=Gene;gene=rpmG1;gene_biotype=protein_coding;gene_synonym=rpmG;locus_tag=Rv2057c
AL123456.3	EMBL	CDS	2314661	2314825	.	-	0	ID=cds-CCP44830.1;Parent=gene-Rv2057c;Dbxref=EnsemblGenomes-Gn:Rv2057c,EnsemblGenomes-Tr:CCP44830,GOA:P9WH97,InterPro:IPR001705,InterPro:IPR011332,InterPro:IPR018264,NCBI_GP:CCP44830.1;Name=CCP44830.1;Note=Rv2057c%2C (MTCY63A.03)%2C len: 54 aa. rpmG1%2C 50S ribosomal protein L33%2C similar to many. Note that previously known as rpmG.;gbkey=CDS;gene=rpmG1;locus_tag=Rv2057c;product=50S ribosomal protein L33 RpmG1;protein_id=CCP44830.1;transl_table=11
AL123456.3	EMBL	gene	2314825	2315061	.	-	.	ID=gene-Rv2058c;Name=rpmB2;gbkey=Gene;gene=rpmB2;gene_biotype=protein_coding;locus_tag=Rv2058c
AL123456.3	EMBL	CDS	2314825	2315061	.	-	0	ID=cds-CCP44831.1;Parent=gene-Rv2058c;Dbxref=EnsemblGenomes-Gn:Rv2058c,EnsemblGenomes-Tr:CCP44831,GOA:P9WHA9,InterPro:IPR001383,InterPro:IPR026569,NCBI_GP:CCP44831.1;Name=CCP44831.1;Note=Rv2058c%2C (MTCY63A.02)%2C len: 78 aa. rpmB2%2C 50S ribosomal protein L28%2C very similar to rL28 of M. tuberculosis. Also similar to rpmB (Rv0105c) of Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpmB2;locus_tag=Rv2058c;product=50S ribosomal protein L28 RpmB2;protein_id=CCP44831.1;transl_table=11
AL123456.3	EMBL	gene	2315174	2316709	.	+	.	ID=gene-Rv2059;Name=Rv2059;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2059
AL123456.3	EMBL	CDS	2315174	2316709	.	+	0	ID=cds-CCP44832.1;Parent=gene-Rv2059;Dbxref=EnsemblGenomes-Gn:Rv2059,EnsemblGenomes-Tr:CCP44832,GOA:O07257,InterPro:IPR006127,UniProtKB/TrEMBL:O07257,NCBI_GP:CCP44832.1;Name=CCP44832.1;Note=Rv2059%2C (MTCY63A.01c)%2C len: 511 aa. Conserved hypothetical protein. Some similarity to EWLA protein gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k (304 aa)%2C FASTA score%2C opt: 287 E(): 6.9e-09%3B 27.2%25 identity in 228 aa overlap. There appears to be a frameshift in this ORF around position 3315980 that causes an overlap with next ORF. C-terminal end of protein may be wrong. No error can be found to account for this.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2059;product=Conserved hypothetical protein;protein_id=CCP44832.1;transl_table=11
AL123456.3	EMBL	gene	2316279	2316680	.	+	.	ID=gene-Rv2060;Name=Rv2060;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2060
AL123456.3	EMBL	CDS	2316279	2316680	.	+	0	ID=cds-CCP44833.1;Parent=gene-Rv2060;Dbxref=EnsemblGenomes-Gn:Rv2060,EnsemblGenomes-Tr:CCP44833,GOA:O86339,InterPro:IPR001626,InterPro:IPR029022,UniProtKB/TrEMBL:O86339,NCBI_GP:CCP44833.1;Name=CCP44833.1;Note=Rv2060%2C (MTV019.01)%2C len: 133 aa. Possible conserved integral membrane protein smaller than but similar to several hypothetical bacterial proteins e.g. >emb|CAC29843.1| (AL583918) putative ABC-transporter transmembrane protein [Mycobacterium leprae] Length %3D 286 and P44691|YEBI_HAEIN (261 aa). FASTA scores: P44691|YEBI_HAEIN hypothetical protein HI0407 (261 aa) opt: 218%2C E(): 4.2e-08%3B 31.1%25 identity in 122 aa overlap. Maybe frameshift upstream at position 3315980 but no error can be found to account for this.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2060;product=Possible conserved integral membrane protein;protein_id=CCP44833.1;transl_table=11
AL123456.3	EMBL	gene	2316681	2317085	.	-	.	ID=gene-Rv2061c;Name=Rv2061c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2061c
AL123456.3	EMBL	CDS	2316681	2317085	.	-	0	ID=cds-CCP44834.1;Parent=gene-Rv2061c;Dbxref=EnsemblGenomes-Gn:Rv2061c,EnsemblGenomes-Tr:CCP44834,GOA:O86340,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019965,UniProtKB/TrEMBL:O86340,NCBI_GP:CCP44834.1;Name=CCP44834.1;Note=Rv2061c%2C (MTV019.02c)%2C len: 134 aa. Conserved protein. Similar to many. Contains IPR019965 F420-dependent enzyme%2C PPOX class%2C family Rv2061%2C domain. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2061c;product=Conserved protein;protein_id=CCP44834.1;transl_table=11
AL123456.3	EMBL	gene	2317169	2320753	.	-	.	ID=gene-Rv2062c;Name=cobN;gbkey=Gene;gene=cobN;gene_biotype=protein_coding;locus_tag=Rv2062c
AL123456.3	EMBL	CDS	2317169	2320753	.	-	0	ID=cds-CCP44835.1;Parent=gene-Rv2062c;Dbxref=EnsemblGenomes-Gn:Rv2062c,EnsemblGenomes-Tr:CCP44835,GOA:O53498,InterPro:IPR003672,InterPro:IPR011953,UniProtKB/TrEMBL:O53498,NCBI_GP:CCP44835.1;Name=CCP44835.1;Note=Rv2062c%2C (MTCY49.01c%2C MTV019.03)%2C len: 1194 aa. cobN%2C cobalamin biosynthesis protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobN;locus_tag=Rv2062c;product=Cobalamin biosynthesis protein CobN;protein_id=CCP44835.1;transl_table=11
AL123456.3	EMBL	gene	2320831	2321064	.	+	.	ID=gene-Rv2063;Name=mazE7;gbkey=Gene;gene=mazE7;gene_biotype=protein_coding;locus_tag=Rv2063
AL123456.3	EMBL	CDS	2320831	2321064	.	+	0	ID=cds-CCP44836.1;Parent=gene-Rv2063;Dbxref=EnsemblGenomes-Gn:Rv2063,EnsemblGenomes-Tr:CCP44836,GOA:P9WJ85,InterPro:IPR002145,NCBI_GP:CCP44836.1;Name=CCP44836.1;Note=Rv2063%2C len: 77 aa. MazE7%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv2063A (See Pandey and Gerdes%2C 2005)%2C similar to many. This ORF replaces previous Rv2063c on other strand.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mazE7;locus_tag=Rv2063;product=Antitoxin MazE7;protein_id=CCP44836.1;transl_table=11
AL123456.3	EMBL	gene	2321057	2321467	.	+	.	ID=gene-Rv2063A;Name=mazF7;gbkey=Gene;gene=mazF7;gene_biotype=protein_coding;locus_tag=Rv2063A
AL123456.3	EMBL	CDS	2321057	2321467	.	+	0	ID=cds-CCP44837.1;Parent=gene-Rv2063A;Dbxref=EnsemblGenomes-Gn:Rv2063A,EnsemblGenomes-Tr:CCP44837,GOA:P0CL62,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP44837.1;Name=CCP44837.1;Note=Rv2063A%2C len: 136 aa. Possible mazF7 toxin%2C part of toxin-antitoxin (TA) operon with Rv2063 (See Pandey and Gerdes%2C 2005).;gbkey=CDS;gene=mazF7;locus_tag=Rv2063A;product=Possible toxin MazF7;protein_id=CCP44837.1;transl_table=11
AL123456.3	EMBL	gene	2321451	2322542	.	+	.	ID=gene-Rv2064;Name=cobG;gbkey=Gene;gene=cobG;gene_biotype=protein_coding;locus_tag=Rv2064
AL123456.3	EMBL	CDS	2321451	2322542	.	+	0	ID=cds-CCP44838.1;Parent=gene-Rv2064;Dbxref=EnsemblGenomes-Gn:Rv2064,EnsemblGenomes-Tr:CCP44838,GOA:Q10675,InterPro:IPR005117,InterPro:IPR012798,UniProtKB/TrEMBL:Q10675,NCBI_GP:CCP44838.1;Name=CCP44838.1;Note=Rv2064%2C (MTCY49.03)%2C len: 363 aa. CobG%2C precorrin-3B synthase%2C cobalamin biosynthesis protein.;gbkey=CDS;gene=cobG;inference=protein motif:PROSITE:PS01156;locus_tag=Rv2064;product=Precorrin-3B synthase CobG;protein_id=CCP44838.1;transl_table=11
AL123456.3	EMBL	gene	2322552	2323178	.	+	.	ID=gene-Rv2065;Name=cobH;gbkey=Gene;gene=cobH;gene_biotype=protein_coding;locus_tag=Rv2065
AL123456.3	EMBL	CDS	2322552	2323178	.	+	0	ID=cds-CCP44839.1;Parent=gene-Rv2065;Dbxref=EnsemblGenomes-Gn:Rv2065,EnsemblGenomes-Tr:CCP44839,GOA:P9WP87,InterPro:IPR003722,NCBI_GP:CCP44839.1;Name=CCP44839.1;Note=Rv2065%2C (MTCY49.04)%2C len: 208 aa. CobH%2C precorrin-8X methylmutase (aka precorrin isomerase)%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobH;locus_tag=Rv2065;product=Precorrin-8X methylmutase CobH (aka precorrin isomerase);protein_id=CCP44839.1;transl_table=11
AL123456.3	EMBL	gene	2323175	2324701	.	+	.	ID=gene-Rv2066;Name=cobI;gbkey=Gene;gene=cobI;gene_biotype=protein_coding;locus_tag=Rv2066
AL123456.3	EMBL	CDS	2323175	2324701	.	+	0	ID=cds-CCP44840.1;Parent=gene-Rv2066;Dbxref=EnsemblGenomes-Gn:Rv2066,EnsemblGenomes-Tr:CCP44840,GOA:P9WGB3,InterPro:IPR000878,InterPro:IPR003043,InterPro:IPR006363,InterPro:IPR006364,InterPro:IPR014776,InterPro:IPR014777,NCBI_GP:CCP44840.1;Name=CCP44840.1;Note=Rv2066%2C (MTCY49.05)%2C len: 508 aa. Probable CobI-CobJ fusion protein%2C S-adenosyl-L-methionine-precorrin-2 methyl transferase and precorrin-3 methylase. Similar in N-terminal half (aa 1-240) to many S-adenosyl-L-methionine-precorrin-2 methyl transferase (244 aa)%2C and in C-terminal half (aa 240-508) to precorrin-3 methylase (254 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobI;locus_tag=Rv2066;product=Probable bifunctional protein%2C CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase;protein_id=CCP44840.1;transl_table=11
AL123456.3	EMBL	gene	2324647	2325870	.	-	.	ID=gene-Rv2067c;Name=Rv2067c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2067c
AL123456.3	EMBL	CDS	2324647	2325870	.	-	0	ID=cds-CCP44841.1;Parent=gene-Rv2067c;Dbxref=EnsemblGenomes-Gn:Rv2067c,EnsemblGenomes-Tr:CCP44841,GOA:P9WLL9,InterPro:IPR013217,InterPro:IPR029063,NCBI_GP:CCP44841.1;Name=CCP44841.1;Note=Rv2067c%2C (MTCY49.06c)%2C len: 407 aa. Conserved protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2067c;product=Conserved protein;protein_id=CCP44841.1;transl_table=11
AL123456.3	EMBL	gene	2325886	2326809	.	-	.	ID=gene-Rv2068c;Name=blaC;gbkey=Gene;gene=blaC;gene_biotype=protein_coding;locus_tag=Rv2068c
AL123456.3	EMBL	CDS	2325886	2326809	.	-	0	ID=cds-CCP44842.1;Parent=gene-Rv2068c;Dbxref=EnsemblGenomes-Gn:Rv2068c,EnsemblGenomes-Tr:CCP44842,GOA:P9WKD3,InterPro:IPR000871,InterPro:IPR012338,InterPro:IPR023650,PDB:2GDN,PDB:3CG5,PDB:3DWZ,PDB:3IQA,PDB:3M6B,PDB:3M6H,PDB:3N6I,PDB:3N7W,PDB:3N8L,PDB:3N8R,PDB:3N8S,PDB:3NBL,PDB:3NC8,PDB:3NCK,PDB:3NDE,PDB:3NDG,PDB:3NY4,PDB:3VFF,PDB:3VFH,PDB:3ZHH,PDB:4DF6,PDB:4EBL,PDB:4EBN,PDB:4EBP,PDB:4JLF,PDB:4Q8I,PDB:4QB8,NCBI_GP:CCP44842.1;Name=CCP44842.1;Note=Rv2068c%2C (MTCY49.07c)%2C len: 307 aa. BlaC%2C class a beta-lactamase (see citation below)%2C similar to many. Contains PS00013 Prokaryotic lipid attachment site near N-terminus%2C and PS00146 Beta-lactamase class-a active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=blaC;inference=protein motif:PROSITE:PS00146;locus_tag=Rv2068c;product=Class a beta-lactamase BlaC;protein_id=CCP44842.1;transl_table=11
AL123456.3	EMBL	gene	2326944	2327501	.	+	.	ID=gene-Rv2069;Name=sigC;gbkey=Gene;gene=sigC;gene_biotype=protein_coding;locus_tag=Rv2069
AL123456.3	EMBL	CDS	2326944	2327501	.	+	0	ID=cds-CCP44843.1;Parent=gene-Rv2069;Dbxref=EnsemblGenomes-Gn:Rv2069,EnsemblGenomes-Tr:CCP44843,GOA:P9WGH1,InterPro:IPR000838,InterPro:IPR007627,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,PDB:2O7G,PDB:2O8X,NCBI_GP:CCP44843.1;Name=CCP44843.1;Note=Rv2069%2C (MTCY49.08)%2C len: 185 aa. SigC%2C RNA polymerase sigma factor%2C ECF subfamily (see Gomez et al.%2C1997%3B Chen et al.%2C 2000)%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigC;locus_tag=Rv2069;product=RNA polymerase sigma factor%2C ECF subfamily%2C SigC;protein_id=CCP44843.1;transl_table=11
AL123456.3	EMBL	gene	2327491	2328225	.	-	.	ID=gene-Rv2070c;Name=cobK;gbkey=Gene;gene=cobK;gene_biotype=protein_coding;locus_tag=Rv2070c
AL123456.3	EMBL	CDS	2327491	2328225	.	-	0	ID=cds-CCP44844.1;Parent=gene-Rv2070c;Dbxref=EnsemblGenomes-Gn:Rv2070c,EnsemblGenomes-Tr:CCP44844,GOA:P9WP89,InterPro:IPR003723,NCBI_GP:CCP44844.1;Name=CCP44844.1;Note=Rv2070c%2C (MTCY49.09c)%2C len: 244 aa. CobK%2Cprecorrin-6x reductase%2C similar to many.;gbkey=CDS;gene=cobK;locus_tag=Rv2070c;product=Precorrin-6X reductase CobK;protein_id=CCP44844.1;transl_table=11
AL123456.3	EMBL	gene	2328222	2328977	.	-	.	ID=gene-Rv2071c;Name=cobM;gbkey=Gene;gene=cobM;gene_biotype=protein_coding;locus_tag=Rv2071c
AL123456.3	EMBL	CDS	2328222	2328977	.	-	0	ID=cds-CCP44845.1;Parent=gene-Rv2071c;Dbxref=EnsemblGenomes-Gn:Rv2071c,EnsemblGenomes-Tr:CCP44845,GOA:P9WGB1,InterPro:IPR000878,InterPro:IPR003043,InterPro:IPR006362,InterPro:IPR014776,InterPro:IPR014777,NCBI_GP:CCP44845.1;Name=CCP44845.1;Note=Rv2071c%2C (MTCY49.10c)%2C len: 251 aa. CobM%2Cprecorrin-3 methylase%2C similar to many. Contains PS00839 Uroporphyrin-III C-methyltransferase signature 1%2C and PS00840 Uroporphyrin-III C-methyltransferase signature 2.;gbkey=CDS;gene=cobM;inference=protein motif:PROSITE:PS00840;locus_tag=Rv2071c;product=Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase);protein_id=CCP44845.1;transl_table=11
AL123456.3	EMBL	gene	2328974	2330146	.	-	.	ID=gene-Rv2072c;Name=cobL;gbkey=Gene;gene=cobL;gene_biotype=protein_coding;locus_tag=Rv2072c
AL123456.3	EMBL	CDS	2328974	2330146	.	-	0	ID=cds-CCP44846.1;Parent=gene-Rv2072c;Dbxref=EnsemblGenomes-Gn:Rv2072c,EnsemblGenomes-Tr:CCP44846,GOA:P9WGA9,InterPro:IPR000878,InterPro:IPR006365,InterPro:IPR012818,InterPro:IPR014008,InterPro:IPR014776,InterPro:IPR014777,InterPro:IPR029063,NCBI_GP:CCP44846.1;Name=CCP44846.1;Note=Rv2072c%2C (MTCY49.11c)%2C len: 390 aa. CobL%2Cprecorrin-6Y C(5%2C15)-methyltransferase (decarboxylating).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobL;locus_tag=Rv2072c;product=Precorrin-6Y C(5%2C15)-methyltransferase (decarboxylating) CobL;protein_id=CCP44846.1;transl_table=11
AL123456.3	EMBL	repeat_region	2330147	2330225	.	-	.	ID=id-AL123456.3:2330147..2330225;Note=79 bp Mycobacterial Interspersed Repetitive Unit%2CClass I;gbkey=repeat_region
AL123456.3	EMBL	gene	2330214	2330963	.	-	.	ID=gene-Rv2073c;Name=Rv2073c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2073c
AL123456.3	EMBL	CDS	2330214	2330963	.	-	0	ID=cds-CCP44847.1;Parent=gene-Rv2073c;Dbxref=EnsemblGenomes-Gn:Rv2073c,EnsemblGenomes-Tr:CCP44847,GOA:P9WGR3,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP44847.1;Name=CCP44847.1;Note=Rv2073c%2C (MTCY49.12c)%2C len: 249 aa. Probable oxidoreductase%2C belonging to shortchain dehydrogenase reductase (SDR) family%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2073c;product=Probable shortchain dehydrogenase;protein_id=CCP44847.1;transl_table=11
AL123456.3	EMBL	gene	2330993	2331406	.	+	.	ID=gene-Rv2074;Name=Rv2074;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2074
AL123456.3	EMBL	CDS	2330993	2331406	.	+	0	ID=cds-CCP44848.1;Parent=gene-Rv2074;Dbxref=EnsemblGenomes-Gn:Rv2074,EnsemblGenomes-Tr:CCP44848,GOA:P9WLL7,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019920,PDB:2ASF,NCBI_GP:CCP44848.1;Name=CCP44848.1;Note=Rv2074%2C (MTCY49.13)%2C len: 137 aa. Possible pyridoxine 5'-phosphate oxidase (PNPOx) (See Biswal et al.%2C2006). Similar to conserved hypothetical proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2074;product=Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase);protein_id=CCP44848.1;transl_table=11
AL123456.3	EMBL	gene	2331416	2332879	.	-	.	ID=gene-Rv2075c;Name=Rv2075c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2075c
AL123456.3	EMBL	CDS	2331416	2332879	.	-	0	ID=cds-CCP44849.1;Parent=gene-Rv2075c;Dbxref=EnsemblGenomes-Gn:Rv2075c,EnsemblGenomes-Tr:CCP44849,GOA:P9WLL5,InterPro:IPR000909,InterPro:IPR016187,InterPro:IPR017946,NCBI_GP:CCP44849.1;Name=CCP44849.1;Note=Rv2075c%2C (MTCY49.14c)%2C len: 487 aa. Possibly exported or envelope protein%3B has potential signal peptide at N-terminus and hydrophobic stretch around residue 430. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2075c;product=Possible hypothetical exported or envelope protein;protein_id=CCP44849.1;transl_table=11
AL123456.3	EMBL	gene	2333037	2333288	.	-	.	ID=gene-Rv2076c;Name=Rv2076c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2076c
AL123456.3	EMBL	CDS	2333037	2333288	.	-	0	ID=cds-CCP44850.1;Parent=gene-Rv2076c;Dbxref=EnsemblGenomes-Gn:Rv2076c,EnsemblGenomes-Tr:CCP44850,GOA:P9WLL3,NCBI_GP:CCP44850.1;Name=CCP44850.1;Note=Rv2076c%2C (MTCY49.15c)%2C len: 83 aa. Conserved hypothetical protein%2C similar to many.;gbkey=CDS;locus_tag=Rv2076c;product=Conserved hypothetical protein;protein_id=CCP44850.1;transl_table=11
AL123456.3	EMBL	gene	2333323	2334294	.	-	.	ID=gene-Rv2077c;Name=Rv2077c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2077c
AL123456.3	EMBL	CDS	2333323	2334294	.	-	0	ID=cds-CCP44851.1;Parent=gene-Rv2077c;Dbxref=EnsemblGenomes-Gn:Rv2077c,EnsemblGenomes-Tr:CCP44851,GOA:P9WLL1,NCBI_GP:CCP44851.1;Name=CCP44851.1;Note=Rv2077c%2C (MTCY49.16c)%2C len: 323 aa. Possible conserved transmembrane protein. Part of Mycobacterium tuberculosis protein family with Rv2542%2C Rv2079%2C Rv2797c%2CRv0963c%2C Rv1949c. Hydrophobic stretches at C-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2077c;product=Possible conserved transmembrane protein;protein_id=CCP44851.1;transl_table=11
AL123456.3	EMBL	gene	2334295	2334594	.	-	.	ID=gene-Rv2077A;Name=Rv2077A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2077A
AL123456.3	EMBL	CDS	2334295	2334594	.	-	0	ID=cds-CCP44852.1;Parent=gene-Rv2077A;Dbxref=EnsemblGenomes-Gn:Rv2077A,EnsemblGenomes-Tr:CCP44852,UniProtKB/TrEMBL:L7N6B8,NCBI_GP:CCP44852.1;Name=CCP44852.1;Note=Rv2077A%2C len: 99 aa. Conserved hypothetical protein%2Csimilar to many.;gbkey=CDS;locus_tag=Rv2077A;product=Conserved hypothetical protein;protein_id=CCP44852.1;transl_table=11
AL123456.3	EMBL	gene	2335059	2335373	.	+	.	ID=gene-Rv2078;Name=Rv2078;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2078
AL123456.3	EMBL	CDS	2335059	2335373	.	+	0	ID=cds-CCP44853.1;Parent=gene-Rv2078;Dbxref=EnsemblGenomes-Gn:Rv2078,EnsemblGenomes-Tr:CCP44853,InterPro:IPR022534,NCBI_GP:CCP44853.1;Name=CCP44853.1;Note=Rv2078%2C (MTCY49.17)%2C len: 104 aa. Conserved hypothetical protein%2C similar to many.;gbkey=CDS;locus_tag=Rv2078;product=Conserved hypothetical protein;protein_id=CCP44853.1;transl_table=11
AL123456.3	EMBL	gene	2335355	2337325	.	+	.	ID=gene-Rv2079;Name=Rv2079;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2079
AL123456.3	EMBL	CDS	2335355	2337325	.	+	0	ID=cds-CCP44854.1;Parent=gene-Rv2079;Dbxref=EnsemblGenomes-Gn:Rv2079,EnsemblGenomes-Tr:CCP44854,InterPro:IPR010427,InterPro:IPR029058,NCBI_GP:CCP44854.1;Name=CCP44854.1;Note=Rv2079%2C (MTCY49.18)%2C len: 656 aa. Conserved hypothetical protein%3B part of Mycobacterium tuberculosis protein family with Rv2542%2C Rv2077c%2C Rv2797c%2C Rv0963c%2CRv1949c. Contains PS00120 Lipases%2C serine active site;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv2079;product=Conserved hypothetical protein;protein_id=CCP44854.1;transl_table=11
AL123456.3	EMBL	gene	2337306	2337869	.	+	.	ID=gene-Rv2080;Name=lppJ;gbkey=Gene;gene=lppJ;gene_biotype=protein_coding;locus_tag=Rv2080
AL123456.3	EMBL	CDS	2337306	2337869	.	+	0	ID=cds-CCP44855.1;Parent=gene-Rv2080;Dbxref=EnsemblGenomes-Gn:Rv2080,EnsemblGenomes-Tr:CCP44855,GOA:P9WK77,NCBI_GP:CCP44855.1;Name=CCP44855.1;Note=Rv2080%2C (MTCY49.19)%2C len: 187 aa. LppJ%2C lipoprotein%3B contains prokayotic lipoprotein modification site (PS00013) and signal sequence at N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppJ;locus_tag=Rv2080;product=Lipoprotein LppJ;protein_id=CCP44855.1;transl_table=11
AL123456.3	EMBL	gene	2338065	2338505	.	-	.	ID=gene-Rv2081c;Name=Rv2081c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2081c
AL123456.3	EMBL	CDS	2338065	2338505	.	-	0	ID=cds-CCP44856.1;Parent=gene-Rv2081c;Dbxref=EnsemblGenomes-Gn:Rv2081c,EnsemblGenomes-Tr:CCP44856,GOA:P9WLK5,NCBI_GP:CCP44856.1;Name=CCP44856.1;Note=Rv2081c%2C (MTCY49.20c)%2C len: 146 aa. Conserved transmembrane protein%2C similar to many. Hydrophobic stretch from aa 32-54.;gbkey=CDS;locus_tag=Rv2081c;product=Conserved transmembrane protein;protein_id=CCP44856.1;transl_table=11
AL123456.3	EMBL	gene	2338709	2340874	.	+	.	ID=gene-Rv2082;Name=Rv2082;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2082
AL123456.3	EMBL	CDS	2338709	2340874	.	+	0	ID=cds-CCP44857.1;Parent=gene-Rv2082;Dbxref=EnsemblGenomes-Gn:Rv2082,EnsemblGenomes-Tr:CCP44857,GOA:Q10690,NCBI_GP:CCP44857.1;Name=CCP44857.1;Note=Rv2082%2C (MTCY49.21)%2C len: 721 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0029%2C and to Rv3899c and Rv3900c which may be frameshifted.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2082;product=Conserved hypothetical protein;protein_id=CCP44857.1;transl_table=11
AL123456.3	EMBL	gene	2340871	2341815	.	+	.	ID=gene-Rv2083;Name=Rv2083;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2083
AL123456.3	EMBL	CDS	2340871	2341815	.	+	0	ID=cds-CCP44858.1;Parent=gene-Rv2083;Dbxref=EnsemblGenomes-Gn:Rv2083,EnsemblGenomes-Tr:CCP44858,GOA:P9WLK3,NCBI_GP:CCP44858.1;Name=CCP44858.1;Note=Rv2083%2C (MTCY49.22)%2C len: 314 aa. Conserved hypothetical protein. Similar to many e.g. Mycobacterium tuberculosis Rv3898c (110 aa) and Rv3897c (210 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2083;product=Conserved hypothetical protein;protein_id=CCP44858.1;transl_table=11
AL123456.3	EMBL	gene	2341808	2342944	.	+	.	ID=gene-Rv2084;Name=Rv2084;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2084
AL123456.3	EMBL	CDS	2341808	2342944	.	+	0	ID=cds-CCP44859.1;Parent=gene-Rv2084;Dbxref=EnsemblGenomes-Gn:Rv2084,EnsemblGenomes-Tr:CCP44859,GOA:P9WLK1,NCBI_GP:CCP44859.1;Name=CCP44859.1;Note=Rv2084%2C (MTCY49.23)%2C len: 378 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2084;product=Hypothetical protein;protein_id=CCP44859.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2342942	2344410	.	+	.	ID=id-AL123456.3:2342942..2344410;Note=IS1556%2C len: 1469 nt. Possible Insertion sequence-like region. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1556
AL123456.3	EMBL	gene	2343027	2343332	.	+	.	ID=gene-Rv2085;Name=Rv2085;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2085
AL123456.3	EMBL	CDS	2343027	2343332	.	+	0	ID=cds-CCP44860.1;Parent=gene-Rv2085;Dbxref=EnsemblGenomes-Gn:Rv2085,EnsemblGenomes-Tr:CCP44860,NCBI_GP:CCP44860.1;Name=CCP44860.1;Note=Rv2085%2C (MTCY49.24)%2C len: 101 aa. Conserved hypothetical protein%2C similar to but shorter than many transposases but we can find no sequence errors to account for the frameshifts. Contains possible helix-turn-helix motif at aa 33 to 54%2C(+3.11 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2085;product=Conserved hypothetical protein;protein_id=CCP44860.1;transl_table=11
AL123456.3	EMBL	gene	2343311	2343916	.	+	.	ID=gene-Rv2086;Name=Rv2086;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2086
AL123456.3	EMBL	CDS	2343311	2343916	.	+	0	ID=cds-CCP44861.1;Parent=gene-Rv2086;Dbxref=EnsemblGenomes-Gn:Rv2086,EnsemblGenomes-Tr:CCP44861,InterPro:IPR025948,NCBI_GP:CCP44861.1;Name=CCP44861.1;Note=Rv2086%2C (MTCY49.25)%2C len: 201 aa. Conserved hypothetical protein%2C similarity to but shorter than many transposases but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-16 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2086;product=Conserved hypothetical protein;protein_id=CCP44861.1;transl_table=11
AL123456.3	EMBL	gene	2343994	2344224	.	+	.	ID=gene-Rv2087;Name=Rv2087;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2087
AL123456.3	EMBL	CDS	2343994	2344224	.	+	0	ID=cds-CCP44862.1;Parent=gene-Rv2087;Dbxref=EnsemblGenomes-Gn:Rv2087,EnsemblGenomes-Tr:CCP44862,NCBI_GP:CCP44862.1;Name=CCP44862.1;Note=Rv2087%2C (MTCY49.27)%2C len: 76 aa. Conserved hypothetical protein%2C similar to but shorter than transposases%2C but we can find no sequence errors to account for the frameshifts. Start changed since first submission (-45 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2087;product=Conserved hypothetical protein;protein_id=CCP44862.1;transl_table=11
AL123456.3	EMBL	gene	2344411	2346180	.	+	.	ID=gene-Rv2088;Name=pknJ;gbkey=Gene;gene=pknJ;gene_biotype=protein_coding;locus_tag=Rv2088
AL123456.3	EMBL	CDS	2344411	2346180	.	+	0	ID=cds-CCP44863.1;Parent=gene-Rv2088;Dbxref=EnsemblGenomes-Gn:Rv2088,EnsemblGenomes-Tr:CCP44863,GOA:P9WI67,InterPro:IPR000719,InterPro:IPR008271,InterPro:IPR011009,InterPro:IPR026954,NCBI_GP:CCP44863.1;Name=CCP44863.1;Note=Rv2088%2C (MTCY49.28)%2C len: 589 aa. PknJ%2Ctransmembrane serine/threonine-protein kinase (see citation below). Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases. Experimental studies show evidence of auto-phosphorylation. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007). Cofactor: requires divalent cations for activity.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknJ;inference=protein motif:PROSITE:PS00108;locus_tag=Rv2088;product=Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J);protein_id=CCP44863.1;transl_table=11
AL123456.3	EMBL	gene	2346197	2347324	.	-	.	ID=gene-Rv2089c;Name=pepE;gbkey=Gene;gene=pepE;gene_biotype=protein_coding;locus_tag=Rv2089c
AL123456.3	EMBL	CDS	2346197	2347324	.	-	0	ID=cds-CCP44864.1;Parent=gene-Rv2089c;Dbxref=EnsemblGenomes-Gn:Rv2089c,EnsemblGenomes-Tr:CCP44864,GOA:P9WHS7,InterPro:IPR000587,InterPro:IPR000994,InterPro:IPR001131,InterPro:IPR028980,InterPro:IPR029149,NCBI_GP:CCP44864.1;Name=CCP44864.1;Note=Rv2089c%2C (MTCY49.29c)%2C len: 375 aa. PepE%2Cdipeptidase%2C similar to many%3B contains PS00491 Aminopeptidase P and proline dipeptidase signature. Also similar to Mycobacterium tuberculosis peptidases Rv2861c%2CRv0734%2C Rv2535c. Phosphorylated in vitro by PknJ|Rv2088 (See Jang et al.%2C 2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepE;inference=protein motif:PROSITE:PS00491;locus_tag=Rv2089c;product=Dipeptidase PepE;protein_id=CCP44864.1;transl_table=11
AL123456.3	EMBL	gene	2347373	2348554	.	+	.	ID=gene-Rv2090;Name=Rv2090;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2090
AL123456.3	EMBL	CDS	2347373	2348554	.	+	0	ID=cds-CCP44865.1;Parent=gene-Rv2090;Dbxref=EnsemblGenomes-Gn:Rv2090,EnsemblGenomes-Tr:CCP44865,GOA:P9WNU3,InterPro:IPR002421,InterPro:IPR003583,InterPro:IPR008918,InterPro:IPR020045,InterPro:IPR020046,InterPro:IPR029060,NCBI_GP:CCP44865.1;Name=CCP44865.1;Note=Rv2090%2C (MTCY49.30)%2C len: 393 aa. Probable 5'-3' exonuclease%2C similar to exonuclease part of DNA polymerase. Belongs to family a of DNA polymerases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2090;product=Probable 5'-3' exonuclease;protein_id=CCP44865.1;transl_table=11
AL123456.3	EMBL	gene	2348558	2349292	.	-	.	ID=gene-Rv2091c;Name=Rv2091c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2091c
AL123456.3	EMBL	CDS	2348558	2349292	.	-	0	ID=cds-CCP44866.1;Parent=gene-Rv2091c;Dbxref=EnsemblGenomes-Gn:Rv2091c,EnsemblGenomes-Tr:CCP44866,GOA:P9WLJ5,InterPro:IPR025637,NCBI_GP:CCP44866.1;Name=CCP44866.1;Note=Rv2091c%2C (MTCY49.31c)%2C len: 244 aa. Probable membrane protein%3B contains potential transmembrane region. Repetitive ORF. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2091c;product=Probable membrane protein;protein_id=CCP44866.1;transl_table=11
AL123456.3	EMBL	gene	2349334	2352054	.	-	.	ID=gene-Rv2092c;Name=helY;gbkey=Gene;gene=helY;gene_biotype=protein_coding;locus_tag=Rv2092c
AL123456.3	EMBL	CDS	2349334	2352054	.	-	0	ID=cds-CCP44867.1;Parent=gene-Rv2092c;Dbxref=EnsemblGenomes-Gn:Rv2092c,EnsemblGenomes-Tr:CCP44867,GOA:P9WMR1,InterPro:IPR001650,InterPro:IPR011545,InterPro:IPR012961,InterPro:IPR014001,InterPro:IPR027417,NCBI_GP:CCP44867.1;Name=CCP44867.1;Note=Rv2092c%2C (MTCY49.32c)%2C len: 906 aa. HelY%2CATP-dependent DNA helicase%2C similar to many%3B contains PS00017 ATP/GTP-binding site motif A%2C PS00402 Binding-protein-dependent transport systems inner membrane component signature. Belongs to the SKI2 subfamily of helicases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=helY;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2092c;product=ATP-dependent DNA helicase HelY;protein_id=CCP44867.1;transl_table=11
AL123456.3	EMBL	gene	2352103	2353029	.	-	.	ID=gene-Rv2093c;Name=tatC;gbkey=Gene;gene=tatC;gene_biotype=protein_coding;locus_tag=Rv2093c
AL123456.3	EMBL	CDS	2352103	2353029	.	-	0	ID=cds-CCP44868.1;Parent=gene-Rv2093c;Dbxref=EnsemblGenomes-Gn:Rv2093c,EnsemblGenomes-Tr:CCP44868,GOA:P9WG97,InterPro:IPR002033,InterPro:IPR019820,NCBI_GP:CCP44868.1;Name=CCP44868.1;Note=Rv2093c%2C (MT2154%2C MTCY49.33c)%2C len: 308 aa. TatC%2Ctransmembrane protein%2C component of twin-arginine translocation protein export system (see citation below)%2Csimilar to many. Belongs to the TatC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tatC;locus_tag=Rv2093c;product=Sec-independent protein translocase transmembrane protein TatC;protein_id=CCP44868.1;transl_table=11
AL123456.3	EMBL	gene	2353046	2353297	.	-	.	ID=gene-Rv2094c;Name=tatA;gbkey=Gene;gene=tatA;gene_biotype=protein_coding;locus_tag=Rv2094c
AL123456.3	EMBL	CDS	2353046	2353297	.	-	0	ID=cds-CCP44869.1;Parent=gene-Rv2094c;Dbxref=EnsemblGenomes-Gn:Rv2094c,EnsemblGenomes-Tr:CCP44869,GOA:P9WGA1,InterPro:IPR003369,InterPro:IPR006312,NCBI_GP:CCP44869.1;Name=CCP44869.1;Note=Rv2094c%2C (MT2155%2C MTCY49.34c)%2C len: 83 aa. TatA%2Cmembrane-bound protein%2C component of twin-arginine translocation protein export system (see Berks et al.%2C2000)%2C similar to many. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the TATA/E family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tatA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2094c;product=Sec-independent protein translocase membrane-bound protein TatA;protein_id=CCP44869.1;transl_table=11
AL123456.3	EMBL	gene	2353365	2354315	.	-	.	ID=gene-Rv2095c;Name=pafC;gbkey=Gene;gene=pafC;gene_biotype=protein_coding;locus_tag=Rv2095c
AL123456.3	EMBL	CDS	2353365	2354315	.	-	0	ID=cds-CCP44870.1;Parent=gene-Rv2095c;Dbxref=EnsemblGenomes-Gn:Rv2095c,EnsemblGenomes-Tr:CCP44870,GOA:P9WIL9,InterPro:IPR026881,InterPro:IPR028349,NCBI_GP:CCP44870.1;Name=CCP44870.1;Note=Rv2095c%2C (MTCY49.35c)%2C len: 316 aa. PafC%2C proteasome accessory factor C%2C similar to many. Contains possible helix-turn-helix motif at aa 25-46%2C (+2.92 SD). PafB|Rv2096c and PafC|Rv2095c interact (See Festa et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pafC;locus_tag=Rv2095c;product=Proteasome accessory factor C PafC;protein_id=CCP44870.1;transl_table=11
AL123456.3	EMBL	gene	2354312	2355310	.	-	.	ID=gene-Rv2096c;Name=pafB;gbkey=Gene;gene=pafB;gene_biotype=protein_coding;locus_tag=Rv2096c
AL123456.3	EMBL	CDS	2354312	2355310	.	-	0	ID=cds-CCP44871.1;Parent=gene-Rv2096c;Dbxref=EnsemblGenomes-Gn:Rv2096c,EnsemblGenomes-Tr:CCP44871,GOA:P9WIM1,InterPro:IPR026881,InterPro:IPR028349,NCBI_GP:CCP44871.1;Name=CCP44871.1;Note=Rv2096c%2C (MTCY49.36c)%2C len: 332 aa. PafB%2C proteasome accessory factor B%2C similar to many. PafB|Rv2096c and PafC|Rv2095c interact (See Festa et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pafB;locus_tag=Rv2096c;product=Proteasome accessory factor B PafB;protein_id=CCP44871.1;transl_table=11
AL123456.3	EMBL	gene	2355319	2356677	.	-	.	ID=gene-Rv2097c;Name=pafA;gbkey=Gene;gene=pafA;gene_biotype=protein_coding;gene_synonym=paf;locus_tag=Rv2097c
AL123456.3	EMBL	CDS	2355319	2356677	.	-	0	ID=cds-CCP44872.1;Parent=gene-Rv2097c;Dbxref=EnsemblGenomes-Gn:Rv2097c,EnsemblGenomes-Tr:CCP44872,GOA:P9WNU7,InterPro:IPR004347,InterPro:IPR022279,NCBI_GP:CCP44872.1;Name=CCP44872.1;Note=Rv2097c%2C (MTCY49.37c)%2C len: 452 aa. PafA%2C proteasome accessory factor A%2C similar to many. Belongs to the carboxylate amine/ammonia ligase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pafA;locus_tag=Rv2097c;product=Proteasome accessory factor a PafA;protein_id=CCP44872.1;transl_table=11
AL123456.3	EMBL	pseudogene	2356729	2358033	.	-	.	ID=gene-Rv2098c;Name=PE_PGRS36;gbkey=Gene;gene=PE_PGRS36;gene_biotype=pseudogene;locus_tag=Rv2098c;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	2356729	2358033	.	-	0	ID=cds-Rv2098c;Parent=gene-Rv2098c;Note=Rv2098c%2C (MTCY49.38c)%2C len: 434 aa. PE_PGRS36%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below). Frameshifted near N-terminus (see Rv2099c|PE21).;gbkey=CDS;gene=PE_PGRS36;locus_tag=Rv2098c;product=PE-PGRS family protein PE_PGRS36;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	pseudogene	2358033	2358206	.	-	.	ID=gene-Rv2099c;Name=PE21;gbkey=Gene;gene=PE21;gene_biotype=pseudogene;locus_tag=Rv2099c;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	2358033	2358206	.	-	0	ID=cds-Rv2099c;Parent=gene-Rv2099c;Note=Rv2099c%2C (MTCY49.39c)%2C len: 58 aa. PE21%2C Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu%2C 2002)%3B 5'-end of Rv2098c|PE_PGRS36|MTCY49.38c%2C then frameshifts. Sequence has been checked%2C no errors found.;gbkey=CDS;gene=PE21;locus_tag=Rv2099c;product=PE family protein PE21;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	2358389	2360041	.	+	.	ID=gene-Rv2100;Name=Rv2100;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2100
AL123456.3	EMBL	CDS	2358389	2360041	.	+	0	ID=cds-CCP44875.1;Parent=gene-Rv2100;Dbxref=EnsemblGenomes-Gn:Rv2100,EnsemblGenomes-Tr:CCP44875,GOA:P9WLJ3,InterPro:IPR003615,InterPro:IPR003870,NCBI_GP:CCP44875.1;Name=CCP44875.1;Note=Rv2100%2C (MTCY49.40)%2C len: 550 aa. Conserved hypothetical protein. Member of Mycobacterium tuberculosis REP13E12 repeat family with Rv1148c%2C Rv1945%2C Rv3467%2CRv0094c%2C Rv1128c%2C Rv1587c%2C Rv1702c%2C Rv3466%2C Rv1588c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2100;product=Conserved hypothetical protein;protein_id=CCP44875.1;transl_table=11
AL123456.3	EMBL	gene	2360240	2363281	.	+	.	ID=gene-Rv2101;Name=helZ;gbkey=Gene;gene=helZ;gene_biotype=protein_coding;locus_tag=Rv2101
AL123456.3	EMBL	CDS	2360240	2363281	.	+	0	ID=cds-CCP44876.1;Parent=gene-Rv2101;Dbxref=EnsemblGenomes-Gn:Rv2101,EnsemblGenomes-Tr:CCP44876,GOA:I6YCF3,InterPro:IPR000330,InterPro:IPR001650,InterPro:IPR014001,InterPro:IPR022138,InterPro:IPR027417,UniProtKB/TrEMBL:I6YCF3,NCBI_GP:CCP44876.1;Name=CCP44876.1;Note=Rv2101%2C (MTV020.01)%2C len: 1013 aa. Probable helZ%2Chelicase%2C similar to many. Nucleotide position 2361623 in the genome sequence has been corrected%2C A:C resulting in M462L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=helZ;locus_tag=Rv2101;product=Probable helicase HelZ;protein_id=CCP44876.1;transl_table=11
AL123456.3	EMBL	gene	2363391	2364107	.	+	.	ID=gene-Rv2102;Name=Rv2102;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2102
AL123456.3	EMBL	CDS	2363391	2364107	.	+	0	ID=cds-CCP44877.1;Parent=gene-Rv2102;Dbxref=EnsemblGenomes-Gn:Rv2102,EnsemblGenomes-Tr:CCP44877,GOA:O53500,InterPro:IPR007527,UniProtKB/TrEMBL:O53500,NCBI_GP:CCP44877.1;Name=CCP44877.1;Note=Rv2102%2C (MTV020.02)%2C len: 238 aa. Conserved hypothetical protein%2C similar to many. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2102;product=Conserved hypothetical protein;protein_id=CCP44877.1;transl_table=11
AL123456.3	EMBL	gene	2364086	2364520	.	-	.	ID=gene-Rv2103c;Name=vapC37;gbkey=Gene;gene=vapC37;gene_biotype=protein_coding;locus_tag=Rv2103c
AL123456.3	EMBL	CDS	2364086	2364520	.	-	0	ID=cds-CCP44878.1;Parent=gene-Rv2103c;Dbxref=EnsemblGenomes-Gn:Rv2103c,EnsemblGenomes-Tr:CCP44878,GOA:O53501,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP44878.1;Name=CCP44878.1;Note=Rv2103c%2C (MTV020.03)%2C len: 144 aa. Possible vapC37%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2104c%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis including Rv0749%2CRv0277c%2C Rv2530c%2C Rv3320c%2C Rv2494%2C Rv2872%2C Rv0617%2C Rv1242 etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC37;locus_tag=Rv2103c;product=Possible toxin VapC37. Contains PIN domain.;protein_id=CCP44878.1;transl_table=11
AL123456.3	EMBL	gene	2364527	2364781	.	-	.	ID=gene-Rv2104c;Name=vapB37;gbkey=Gene;gene=vapB37;gene_biotype=protein_coding;locus_tag=Rv2104c
AL123456.3	EMBL	CDS	2364527	2364781	.	-	0	ID=cds-CCP44879.1;Parent=gene-Rv2104c;Dbxref=EnsemblGenomes-Gn:Rv2104c,EnsemblGenomes-Tr:CCP44879,NCBI_GP:CCP44879.1;Name=CCP44879.1;Note=Rv2104c%2C (MTV020.04)%2C len: 84 aa. Possible vapB37%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2103c%2C see Arcus et al. 2005. Similar to others in M. tuberculosis including Rv2871%2C Rv1241%2C Rv2132%2C Rv3321c%2CRv1113%2C Rv0657%2C Rv1560%2C etc.;gbkey=CDS;gene=vapB37;locus_tag=Rv2104c;product=Possible antitoxin VapB37;protein_id=CCP44879.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2365414	2366768	.	+	.	ID=id-AL123456.3:2365414..2366768;Note=IS6110-5%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-5
AL123456.3	EMBL	repeat_region	2365414	2365441	.	+	.	ID=id-AL123456.3:2365414..2365441;Note=28bp inverted repeat at the left end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	2365465	2365791	.	+	.	ID=gene-Rv2105;Name=Rv2105;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2105
AL123456.3	EMBL	CDS	2365465	2365791	.	+	0	ID=cds-CCP44880.1;Parent=gene-Rv2105;Dbxref=EnsemblGenomes-Gn:Rv2105,EnsemblGenomes-Tr:CCP44880,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP44880.1;Name=CCP44880.1;Note=Rv2105%2C (MTCY261.01)%2C len: 108 aa. Putative transposase for IS6110 (fragment)%2C identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion element IS6110 hypothetical 12.0 kDa protein (108 aa)%2C fasta scores: E(): 1.4e-43%2C(100.00%25 identity in 108 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2105 and Rv2106%2C the sequence UUUUAAAG (directly upstream of Rv2106) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv2105;product=Putative transposase for insertion sequence element IS6110 (fragment);protein_id=CCP44880.1;transl_table=11
AL123456.3	EMBL	gene	2365740	2366726	.	+	.	ID=gene-Rv2106;Name=Rv2106;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2106;partial=true;start_range=.,2365740
AL123456.3	EMBL	CDS	2365740	2366726	.	+	0	ID=cds-CCP44881.1;Parent=gene-Rv2106;Dbxref=EnsemblGenomes-Gn:Rv2106,EnsemblGenomes-Tr:CCP44881,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP44881.1;Name=CCP44881.1;Note=Rv2106%2C (MTCY261.02)%2C len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2105 and Rv2106%2C the sequence UUUUAAAG (directly upstream of Rv2106) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 16 aa).;gbkey=CDS;locus_tag=Rv2106;partial=true;product=Probable transposase;protein_id=CCP44881.1;start_range=.,2365740;transl_table=11
AL123456.3	EMBL	repeat_region	2366741	2366768	.	-	.	ID=id-AL123456.3:2366741..2366768;Note=28bp inverted repeat at the right end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	2367359	2367655	.	+	.	ID=gene-Rv2107;Name=PE22;gbkey=Gene;gene=PE22;gene_biotype=protein_coding;locus_tag=Rv2107
AL123456.3	EMBL	CDS	2367359	2367655	.	+	0	ID=cds-CCP44882.1;Parent=gene-Rv2107;Dbxref=EnsemblGenomes-Gn:Rv2107,EnsemblGenomes-Tr:CCP44882,InterPro:IPR000084,UniProtKB/TrEMBL:L7N6B5,NCBI_GP:CCP44882.1;Name=CCP44882.1;Note=Rv2107%2C (MTCY261.03)%2C len: 98 aa. PE22%2C Member of mycobacterial PE family (see citation below). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=PE22;locus_tag=Rv2107;product=PE family protein PE22;protein_id=CCP44882.1;transl_table=11
AL123456.3	EMBL	gene	2367711	2368442	.	+	.	ID=gene-Rv2108;Name=PPE36;gbkey=Gene;gene=PPE36;gene_biotype=protein_coding;locus_tag=Rv2108
AL123456.3	EMBL	CDS	2367711	2368442	.	+	0	ID=cds-CCP44883.1;Parent=gene-Rv2108;Dbxref=EnsemblGenomes-Gn:Rv2108,EnsemblGenomes-Tr:CCP44883,GOA:P9WI01,InterPro:IPR000030,NCBI_GP:CCP44883.1;Name=CCP44883.1;Note=Rv2108%2C (MTCY261.04)%2C len: 243 aa. PPE36%2C Member of the Mycobacterium tuberculosis PE family: N-terminus is similar to N-terminal region of Mycobacterium tuberculosis PPE family proteins. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=PPE36;locus_tag=Rv2108;product=PPE family protein PPE36;protein_id=CCP44883.1;transl_table=11
AL123456.3	EMBL	gene	2368983	2369729	.	-	.	ID=gene-Rv2109c;Name=prcA;gbkey=Gene;gene=prcA;gene_biotype=protein_coding;locus_tag=Rv2109c
AL123456.3	EMBL	CDS	2368983	2369729	.	-	0	ID=cds-CCP44884.1;Parent=gene-Rv2109c;Dbxref=EnsemblGenomes-Gn:Rv2109c,EnsemblGenomes-Tr:CCP44884,GOA:P9WHU1,InterPro:IPR001353,InterPro:IPR022296,InterPro:IPR023332,InterPro:IPR029055,PDB:2FHG,PDB:2FHH,PDB:3H6F,PDB:3H6I,PDB:3HF9,PDB:3HFA,PDB:3KRD,PDB:3MFE,PDB:3MI0,PDB:3MKA,NCBI_GP:CCP44884.1;Name=CCP44884.1;Note=Rv2109c%2C (MTCY261.05c)%2C len: 248 aa. PrcA%2Cproteasome alpha-type subunit 1. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007). prcBA genes encode a proteasome with broad substrate specificity (See Lin et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prcA;locus_tag=Rv2109c;product=Proteasome alpha subunit PrcA%3B assembles with beta subunit PrcB.;protein_id=CCP44884.1;transl_table=11
AL123456.3	EMBL	gene	2369726	2370601	.	-	.	ID=gene-Rv2110c;Name=prcB;gbkey=Gene;gene=prcB;gene_biotype=protein_coding;locus_tag=Rv2110c
AL123456.3	EMBL	CDS	2369726	2370601	.	-	0	ID=cds-CCP44885.1;Parent=gene-Rv2110c;Dbxref=EnsemblGenomes-Gn:Rv2110c,EnsemblGenomes-Tr:CCP44885,GOA:P9WHT9,InterPro:IPR001353,InterPro:IPR022483,InterPro:IPR023333,InterPro:IPR029055,PDB:2FHG,PDB:2FHH,PDB:2JAY,PDB:3H6F,PDB:3H6I,PDB:3HF9,PDB:3HFA,PDB:3KRD,PDB:3MFE,PDB:3MI0,PDB:3MKA,NCBI_GP:CCP44885.1;Name=CCP44885.1;Note=Rv2110c%2C (MTCY261.06c)%2C len: 291 aa. PrcB%2Cproteasome beta-type subunit 2. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007). prcBA genes encode a proteasome with broad substrate specificity (See Lin et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prcB;locus_tag=Rv2110c;product=Proteasome beta subunit PrcB%3B assembles with alpha subunit PrcA.;protein_id=CCP44885.1;transl_table=11
AL123456.3	EMBL	gene	2370598	2370792	.	-	.	ID=gene-Rv2111c;Name=pup;gbkey=Gene;gene=pup;gene_biotype=protein_coding;locus_tag=Rv2111c
AL123456.3	EMBL	CDS	2370598	2370792	.	-	0	ID=cds-CCP44886.1;Parent=gene-Rv2111c;Dbxref=EnsemblGenomes-Gn:Rv2111c,EnsemblGenomes-Tr:CCP44886,GOA:P9WHN5,InterPro:IPR008515,PDB:3M91,PDB:3M9D,NCBI_GP:CCP44886.1;Name=CCP44886.1;Note=Rv2111c%2C MTCY261.07c%2C len: 64 aa. Pup%2C prokaryotic ubiquitin-like protein (See Pearce et al.%2C 2008). Highly similar to many. Pup|Rv2111c and Mpa|Rv2115c interact (See Pearce et al.%2C 2008).;gbkey=CDS;gene=pup;locus_tag=Rv2111c;product=Prokaryotic ubiquitin-like protein Pup;protein_id=CCP44886.1;transl_table=11
AL123456.3	EMBL	gene	2370905	2372569	.	-	.	ID=gene-Rv2112c;Name=dop;gbkey=Gene;gene=dop;gene_biotype=protein_coding;locus_tag=Rv2112c
AL123456.3	EMBL	CDS	2370905	2372569	.	-	0	ID=cds-CCP44887.1;Parent=gene-Rv2112c;Dbxref=EnsemblGenomes-Gn:Rv2112c,EnsemblGenomes-Tr:CCP44887,GOA:P9WNU9,InterPro:IPR004347,InterPro:IPR022366,NCBI_GP:CCP44887.1;Name=CCP44887.1;Note=Rv2112c%2C (MTCY261.08c)%2C len: 554 aa. Dop%2C deamidase of Pup (See Streibel et al.%2C 2009). Highly similar to many. Cofactor: ATP. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dop;locus_tag=Rv2112c;product=Deamidase of pup Dop;protein_id=CCP44887.1;transl_table=11
AL123456.3	EMBL	repeat_region	2372437	2372492	.	+	.	ID=id-AL123456.3:2372437..2372492;Note=56 bp direct repeat 1%2C GCCCGCCGACGATGCGGGCCGCGCAGCGGGCCGCTGAGGAGGCGGGCATCAAGCAA;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2372494	2372549	.	+	.	ID=id-AL123456.3:2372494..2372549;Note=56 bp direct repeat 2%2C GCCCGCCGACGATGCGGGCCGCGCAGCGGGCCGCTGAGGAGGCGGGCATCAAGCAA;gbkey=repeat_region
AL123456.3	EMBL	gene	2372630	2373823	.	+	.	ID=gene-Rv2113;Name=Rv2113;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2113
AL123456.3	EMBL	CDS	2372630	2373823	.	+	0	ID=cds-CCP44888.1;Parent=gene-Rv2113;Dbxref=EnsemblGenomes-Gn:Rv2113,EnsemblGenomes-Tr:CCP44888,GOA:O33248,UniProtKB/TrEMBL:O33248,NCBI_GP:CCP44888.1;Name=CCP44888.1;Note=Rv2113%2C (MTCY261.09)%2C len: 397 aa. Probable integral membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2113;product=Probable integral membrane protein;protein_id=CCP44888.1;transl_table=11
AL123456.3	EMBL	gene	2373834	2374457	.	+	.	ID=gene-Rv2114;Name=Rv2114;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2114
AL123456.3	EMBL	CDS	2373834	2374457	.	+	0	ID=cds-CCP44889.1;Parent=gene-Rv2114;Dbxref=EnsemblGenomes-Gn:Rv2114,EnsemblGenomes-Tr:CCP44889,GOA:O33249,InterPro:IPR016792,UniProtKB/TrEMBL:O33249,NCBI_GP:CCP44889.1;Name=CCP44889.1;Note=Rv2114%2C (MTCY261.10)%2C len: 207 aa. Conserved protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2114;product=Conserved protein;protein_id=CCP44889.1;transl_table=11
AL123456.3	EMBL	gene	2374461	2376290	.	-	.	ID=gene-Rv2115c;Name=mpa;gbkey=Gene;gene=mpa;gene_biotype=protein_coding;locus_tag=Rv2115c
AL123456.3	EMBL	CDS	2374461	2376290	.	-	0	ID=cds-CCP44890.1;Parent=gene-Rv2115c;Dbxref=EnsemblGenomes-Gn:Rv2115c,EnsemblGenomes-Tr:CCP44890,GOA:P9WQN5,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR003960,InterPro:IPR022482,InterPro:IPR027417,PDB:3FP9,PDB:3M91,PDB:3M9B,PDB:3M9D,PDB:3M9H,NCBI_GP:CCP44890.1;Name=CCP44890.1;Note=Rv2115c%2C (MTCY261.11c)%2C len: 609 aa. Mpa%2Cmycobacterial proteasome ATPase%2C similar to many. Contains PS00674 AAA-protein family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Identified as a substrate for proteasomal degradation (See Pearce et al.%2C2006). Pup|Rv2111c and Mpa|Rv2115c interact (See Pearce et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mpa;inference=protein motif:PROSITE:PS00674;locus_tag=Rv2115c;product=Mycobacterial proteasome ATPase Mpa;protein_id=CCP44890.1;transl_table=11
AL123456.3	EMBL	gene	2376571	2377140	.	+	.	ID=gene-Rv2116;Name=lppK;gbkey=Gene;gene=lppK;gene_biotype=protein_coding;locus_tag=Rv2116
AL123456.3	EMBL	CDS	2376571	2377140	.	+	0	ID=cds-CCP44891.1;Parent=gene-Rv2116;Dbxref=EnsemblGenomes-Gn:Rv2116,EnsemblGenomes-Tr:CCP44891,GOA:P9WK75,InterPro:IPR020235,NCBI_GP:CCP44891.1;Name=CCP44891.1;Note=Rv2116%2C (MTCY261.12)%2C len: 189 aa. LppK%2C conserved lipoprotein%2C similar to many. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to Rv2376c. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppK;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2116;product=Conserved lipoprotein LppK;protein_id=CCP44891.1;transl_table=11
AL123456.3	EMBL	gene	2377148	2377441	.	+	.	ID=gene-Rv2117;Name=Rv2117;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2117
AL123456.3	EMBL	CDS	2377148	2377441	.	+	0	ID=cds-CCP44892.1;Parent=gene-Rv2117;Dbxref=EnsemblGenomes-Gn:Rv2117,EnsemblGenomes-Tr:CCP44892,InterPro:IPR007546,UniProtKB/TrEMBL:O33252,NCBI_GP:CCP44892.1;Name=CCP44892.1;Note=Rv2117%2C (MTCY261.13)%2C len: 97 aa. Conserved hypothetical protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2117;product=Conserved hypothetical protein;protein_id=CCP44892.1;transl_table=11
AL123456.3	EMBL	gene	2377470	2378312	.	-	.	ID=gene-Rv2118c;Name=Rv2118c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2118c
AL123456.3	EMBL	CDS	2377470	2378312	.	-	0	ID=cds-CCP44893.1;Parent=gene-Rv2118c;Dbxref=EnsemblGenomes-Gn:Rv2118c,EnsemblGenomes-Tr:CCP44893,GOA:P9WFZ1,InterPro:IPR014816,InterPro:IPR029063,PDB:1I9G,NCBI_GP:CCP44893.1;Name=CCP44893.1;Note=Rv2118c%2C (MTCY261.14c)%2C len: 280 aa. S-adenosyl-l-methionine-dependent RNA methyltransferase (see citation below)%2C similar to many. The larger catalytic C-terminal domain binds the cofactor S-adenosyl-l-methionine (AdoMet) and is involved in the transfer of methyl group from AdoMet to the substrate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2118c;product=RNA methyltransferase;protein_id=CCP44893.1;transl_table=11
AL123456.3	EMBL	gene	2378386	2379222	.	+	.	ID=gene-Rv2119;Name=Rv2119;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2119
AL123456.3	EMBL	CDS	2378386	2379222	.	+	0	ID=cds-CCP44894.1;Parent=gene-Rv2119;Dbxref=EnsemblGenomes-Gn:Rv2119,EnsemblGenomes-Tr:CCP44894,GOA:O33254,InterPro:IPR011335,UniProtKB/TrEMBL:O33254,NCBI_GP:CCP44894.1;Name=CCP44894.1;Note=Rv2119%2C (MTCY261.15)%2C len: 278 aa. Conserved hypothetical protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2119;product=Conserved hypothetical protein;protein_id=CCP44894.1;transl_table=11
AL123456.3	EMBL	gene	2379245	2379727	.	-	.	ID=gene-Rv2120c;Name=Rv2120c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2120c
AL123456.3	EMBL	CDS	2379245	2379727	.	-	0	ID=cds-CCP44895.1;Parent=gene-Rv2120c;Dbxref=EnsemblGenomes-Gn:Rv2120c,EnsemblGenomes-Tr:CCP44895,UniProtKB/TrEMBL:O33255,NCBI_GP:CCP44895.1;Name=CCP44895.1;Note=Rv2120c%2C (MTCY261.16c)%2C len: 160 aa. Probable conserved integral membrane protein%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2120c;product=Probable conserved integral membrane protein;protein_id=CCP44895.1;transl_table=11
AL123456.3	EMBL	gene	2379806	2380660	.	-	.	ID=gene-Rv2121c;Name=hisG;gbkey=Gene;gene=hisG;gene_biotype=protein_coding;locus_tag=Rv2121c
AL123456.3	EMBL	CDS	2379806	2380660	.	-	0	ID=cds-CCP44896.1;Parent=gene-Rv2121c;Dbxref=EnsemblGenomes-Gn:Rv2121c,EnsemblGenomes-Tr:CCP44896,GOA:P9WMN1,InterPro:IPR001348,InterPro:IPR011322,InterPro:IPR013115,InterPro:IPR013820,InterPro:IPR015867,InterPro:IPR018198,InterPro:IPR020621,PDB:1NH7,PDB:1NH8,NCBI_GP:CCP44896.1;Name=CCP44896.1;Note=Rv2121c%2C (MTCY261.17c)%2C len: 284 aa. HisG%2C ATP phosphoribosyltransferase (see citation below)%2C similar to many.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisG;locus_tag=Rv2121c;product=ATP phosphoribosyltransferase HisG;protein_id=CCP44896.1;transl_table=11
AL123456.3	EMBL	gene	2380663	2380944	.	-	.	ID=gene-Rv2122c;Name=hisE;gbkey=Gene;gene=hisE;gene_biotype=protein_coding;gene_synonym=irg1;locus_tag=Rv2122c
AL123456.3	EMBL	CDS	2380663	2380944	.	-	0	ID=cds-CCP44897.1;Parent=gene-Rv2122c;Dbxref=EnsemblGenomes-Gn:Rv2122c,EnsemblGenomes-Tr:CCP44897,GOA:P9WMM9,InterPro:IPR008179,InterPro:IPR021130,PDB:1Y6X,PDB:3C90,NCBI_GP:CCP44897.1;Name=CCP44897.1;Note=Rv2122c%2C (MTCY261.18)%2C len: 93 aa. HisE (alternate gene name: irg1)%2C phosphoribosyl-AMP cyclohydrolase (see citation below)%2C similar to many. Note that previously misnamed hisI.;gbkey=CDS;gene=hisE;locus_tag=Rv2122c;product=Phosphoribosyl-AMP pyrophosphatase HisE;protein_id=CCP44897.1;transl_table=11
AL123456.3	EMBL	gene	2381071	2382492	.	+	.	ID=gene-Rv2123;Name=PPE37;gbkey=Gene;gene=PPE37;gene_biotype=protein_coding;gene_synonym=irg2;locus_tag=Rv2123
AL123456.3	EMBL	CDS	2381071	2382492	.	+	0	ID=cds-CCP44898.1;Parent=gene-Rv2123;Dbxref=EnsemblGenomes-Gn:Rv2123,EnsemblGenomes-Tr:CCP44898,GOA:Q79FH3,InterPro:IPR000030,NCBI_GP:CCP44898.1;Name=CCP44898.1;Note=Rv2123%2C (MTCY261.19)%2C len: 473 aa. PPE37 (alternate gene name: irg2)%2C member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below).;gbkey=CDS;gene=PPE37;locus_tag=Rv2123;product=PPE family protein PPE37;protein_id=CCP44898.1;transl_table=11
AL123456.3	EMBL	gene	2382489	2386067	.	-	.	ID=gene-Rv2124c;Name=metH;gbkey=Gene;gene=metH;gene_biotype=protein_coding;locus_tag=Rv2124c
AL123456.3	EMBL	CDS	2382489	2386067	.	-	0	ID=cds-CCP44899.1;Parent=gene-Rv2124c;Dbxref=EnsemblGenomes-Gn:Rv2124c,EnsemblGenomes-Tr:CCP44899,GOA:O33259,InterPro:IPR000489,InterPro:IPR003726,InterPro:IPR003759,InterPro:IPR004223,InterPro:IPR006158,InterPro:IPR011005,InterPro:IPR011822,NCBI_GP:CCP44899.1;Name=CCP44899.1;Note=Rv2124c%2C (MTCY261.20c)%2C len: 1192 aa. MetH%2Cmethionine synthase%2C similar to many. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to the vitamin-B12 dependent methionine synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metH;inference=protein motif:PROSITE:PS00178;locus_tag=Rv2124c;product=5-methyltetrahydrofolate--homocystein methyltransferase MetH (methionine synthase%2C vitamin-B12 dependent isozyme) (ms);protein_id=CCP44899.1;transl_table=11
AL123456.3	EMBL	gene	2386293	2387171	.	+	.	ID=gene-Rv2125;Name=Rv2125;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2125
AL123456.3	EMBL	CDS	2386293	2387171	.	+	0	ID=cds-CCP44900.1;Parent=gene-Rv2125;Dbxref=EnsemblGenomes-Gn:Rv2125,EnsemblGenomes-Tr:CCP44900,InterPro:IPR008492,InterPro:IPR019151,UniProtKB/TrEMBL:O33260,NCBI_GP:CCP44900.1;Name=CCP44900.1;Note=Rv2125%2C (MTCY261.21)%2C len: 292 aa. Conserved hypothetical protein%2C similar to many.;gbkey=CDS;locus_tag=Rv2125;product=Conserved hypothetical protein;protein_id=CCP44900.1;transl_table=11
AL123456.3	EMBL	gene	2387202	2387972	.	-	.	ID=gene-Rv2126c;Name=PE_PGRS37;gbkey=Gene;gene=PE_PGRS37;gene_biotype=protein_coding;locus_tag=Rv2126c
AL123456.3	EMBL	CDS	2387202	2387972	.	-	0	ID=cds-CCP44901.1;Parent=gene-Rv2126c;Dbxref=EnsemblGenomes-Gn:Rv2126c,EnsemblGenomes-Tr:CCP44901,UniProtKB/TrEMBL:L0TBL4,NCBI_GP:CCP44901.1;Name=CCP44901.1;Note=Rv2126c%2C (MTCY261.22c)%2C len: 256 aa. PE_PGRS37%2CPossible PE_PGRS pseudogene fragment%2C similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS37;locus_tag=Rv2126c;product=PE-PGRS family protein PE_PGRS37;protein_id=CCP44901.1;transl_table=11
AL123456.3	EMBL	gene	2388616	2390085	.	+	.	ID=gene-Rv2127;Name=ansP1;gbkey=Gene;gene=ansP1;gene_biotype=protein_coding;locus_tag=Rv2127
AL123456.3	EMBL	CDS	2388616	2390085	.	+	0	ID=cds-CCP44902.1;Parent=gene-Rv2127;Dbxref=EnsemblGenomes-Gn:Rv2127,EnsemblGenomes-Tr:CCP44902,GOA:P9WQM9,InterPro:IPR002293,InterPro:IPR004840,InterPro:IPR004841,NCBI_GP:CCP44902.1;Name=CCP44902.1;Note=Rv2127%2C (MTCY261.26)%2C len: 489 aa. AnsP1%2CL-asparagine permease%2C integral membrane protein similar to many. Contains PS00218 Amino acid permeases signature. Seems to belong to the APC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ansP1;inference=protein motif:PROSITE:PS00218;locus_tag=Rv2127;product=L-asparagine permease AnsP1;protein_id=CCP44902.1;transl_table=11
AL123456.3	EMBL	gene	2390085	2390288	.	+	.	ID=gene-Rv2128;Name=Rv2128;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2128
AL123456.3	EMBL	CDS	2390085	2390288	.	+	0	ID=cds-CCP44903.1;Parent=gene-Rv2128;Dbxref=EnsemblGenomes-Gn:Rv2128,EnsemblGenomes-Tr:CCP44903,GOA:O33262,UniProtKB/TrEMBL:O33262,NCBI_GP:CCP44903.1;Name=CCP44903.1;Note=Rv2128%2C (MTCY26.27)%2C len: 67 aa. Conserved transmembrane protein%2C similar to many.;gbkey=CDS;locus_tag=Rv2128;product=Conserved transmembrane protein;protein_id=CCP44903.1;transl_table=11
AL123456.3	EMBL	gene	2390308	2391189	.	-	.	ID=gene-Rv2129c;Name=Rv2129c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2129c
AL123456.3	EMBL	CDS	2390308	2391189	.	-	0	ID=cds-CCP44904.1;Parent=gene-Rv2129c;Dbxref=EnsemblGenomes-Gn:Rv2129c,EnsemblGenomes-Tr:CCP44904,GOA:O33263,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O33263,NCBI_GP:CCP44904.1;Name=CCP44904.1;Note=Rv2129c%2C (MTCY261.28)%2C len: 293 aa. Probable oxidoreductase%2C similar to many e.g. FABG_SYNY3|P73826 3-oxoacyl-[acyl-carrier protein] reductase (240 aa)%2C FASTA scores: opt: 241%2C E(): 5.1e-17%2C (32.7%25 identity in 196 aa overlap)%3B etc. Also similar to a number of other Mycobacterium tuberculosis oxidoreductases e.g. MTCY210.04 (34.1%25 identity in 217 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2129c;product=Probable oxidoreductase;protein_id=CCP44904.1;transl_table=11
AL123456.3	EMBL	gene	2391215	2392459	.	-	.	ID=gene-Rv2130c;Name=mshC;gbkey=Gene;gene=mshC;gene_biotype=protein_coding;gene_synonym=cysS2;locus_tag=Rv2130c
AL123456.3	EMBL	CDS	2391215	2392459	.	-	0	ID=cds-CCP44905.1;Parent=gene-Rv2130c;Dbxref=EnsemblGenomes-Gn:Rv2130c,EnsemblGenomes-Tr:CCP44905,GOA:P9WJM9,InterPro:IPR014729,InterPro:IPR017812,InterPro:IPR024909,NCBI_GP:CCP44905.1;Name=CCP44905.1;Note=Rv2130c%2C (MTCY261.29c)%2C len: 414 aa. MshC%2Ccysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase (see Rawat et al.%2C 2002)%2C similar to several cysteinyl-tRNA synthetases e.g. SYC_ECOLI|P21888 cysteinyl-tRNA synthetase from Escherichia coli (461 aa)%2CFASTA scores: opt: 535%2C E(): 0%2C (37.0%25 identity in 370 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis cysS|Rv3580c|MTCY06G11.27c%2C (35.8%25 identity in 372 aa overlap). Contains a match to Pfam entry PF01406 tRNA synthetases class I (C). Previously known as cysS2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mshC;locus_tag=Rv2130c;product=Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC;protein_id=CCP44905.1;transl_table=11
AL123456.3	EMBL	gene	2392517	2393320	.	-	.	ID=gene-Rv2131c;Name=cysQ;gbkey=Gene;gene=cysQ;gene_biotype=protein_coding;locus_tag=Rv2131c
AL123456.3	EMBL	CDS	2392517	2393320	.	-	0	ID=cds-CCP44906.1;Parent=gene-Rv2131c;Dbxref=EnsemblGenomes-Gn:Rv2131c,EnsemblGenomes-Tr:CCP44906,GOA:P9WKJ1,InterPro:IPR000760,InterPro:IPR020583,NCBI_GP:CCP44906.1;Name=CCP44906.1;Note=Rv2131c%2C (MTCY270.37)%2C len: 267 aa. CysQ%2Cmonophosphatase%2C equivalent to CYSQ_MYCLE|P46726 cysQ protein homolog from Mycobacterium leprae (289 aa)%2C FASTA scores: opt: 1374%2C E(): 0%2C (77.3%25 identity in 264 aa overlap). Contains inositol monophosphatase family signature 1 (PS00629)%2C significance uncertain. Seems to belong to the inositol monophosphatase family. Cofactor: Mg2+. Inhibited by Li+%3B PAPase activity is inhibited by Na+ and K+%2C but IMPase activity is not (See Gu et al.%2C 2006%3B Hatzios et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysQ;inference=protein motif:PROSITE:PS00629;locus_tag=Rv2131c;product=Monophosphatase CysQ;protein_id=CCP44906.1;transl_table=11
AL123456.3	EMBL	gene	2393411	2393641	.	+	.	ID=gene-Rv2132;Name=Rv2132;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2132
AL123456.3	EMBL	CDS	2393411	2393641	.	+	0	ID=cds-CCP44907.1;Parent=gene-Rv2132;Dbxref=EnsemblGenomes-Gn:Rv2132,EnsemblGenomes-Tr:CCP44907,GOA:O06243,InterPro:IPR002145,UniProtKB/TrEMBL:O06243,NCBI_GP:CCP44907.1;Name=CCP44907.1;Note=Rv2132%2C (MTCY270.36c)%2C len: 76 aa. Conserved hypothetical protein. Function unknown but belongs to Mycobacterium tuberculosis protein family including Rv2871%2CRv1241%2C Rv3321c%2C Rv1113%2C Rv0657c%2C Rv1560%2C Rv2104c%2C etc. Similarity to Mycobacterium tuberculosis protein Rv2871 (AL021924|MTV020_4%2C 84 aa). FASTA score: opt: 142%2C E(): 0.00036%3B 41.8%25 identity in 55 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2132;product=Conserved hypothetical protein;protein_id=CCP44907.1;transl_table=11
AL123456.3	EMBL	gene	2393851	2394639	.	-	.	ID=gene-Rv2133c;Name=Rv2133c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2133c
AL123456.3	EMBL	CDS	2393851	2394639	.	-	0	ID=cds-CCP44908.1;Parent=gene-Rv2133c;Dbxref=EnsemblGenomes-Gn:Rv2133c,EnsemblGenomes-Tr:CCP44908,GOA:O06242,InterPro:IPR000403,InterPro:IPR022292,UniProtKB/TrEMBL:O06242,NCBI_GP:CCP44908.1;Name=CCP44908.1;Note=Rv2133c%2C (MTCY270.35)%2C len: 262 aa. Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein%2C Q49774. FASTA best: Q49774 B2126_C1_150 (262 aa) opt: 1447%2C E(): 0%3B (79.0%25 identity in 262 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2133c;product=Conserved hypothetical protein;protein_id=CCP44908.1;transl_table=11
AL123456.3	EMBL	gene	2394650	2395237	.	-	.	ID=gene-Rv2134c;Name=Rv2134c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2134c
AL123456.3	EMBL	CDS	2394650	2395237	.	-	0	ID=cds-CCP44909.1;Parent=gene-Rv2134c;Dbxref=EnsemblGenomes-Gn:Rv2134c,EnsemblGenomes-Tr:CCP44909,InterPro:IPR021441,UniProtKB/TrEMBL:O06241,NCBI_GP:CCP44909.1;Name=CCP44909.1;Note=Rv2134c%2C (MTCY270.34)%2C len: 195 aa. Conserved protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein%2C Q49789. FASTA best: Q49789 B2126_C3_228%2C opt: 1192%2C E(): 0 (91.1%25 identity in 192 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2134c;product=Conserved protein;protein_id=CCP44909.1;transl_table=11
AL123456.3	EMBL	gene	2395301	2396011	.	-	.	ID=gene-Rv2135c;Name=Rv2135c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2135c
AL123456.3	EMBL	CDS	2395301	2396011	.	-	0	ID=cds-CCP44910.1;Parent=gene-Rv2135c;Dbxref=EnsemblGenomes-Gn:Rv2135c,EnsemblGenomes-Tr:CCP44910,InterPro:IPR013078,InterPro:IPR022492,InterPro:IPR029033,UniProtKB/TrEMBL:O06240,NCBI_GP:CCP44910.1;Name=CCP44910.1;Note=Rv2135c%2C (MTCY270.33)%2C len: 236 aa. Conserved protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein%2C Q49773. FASTA best: Q49773 B2126_C1_148 opt: 1183%2C E() : 0%3B (74.8%25 identity in 250 aa overlap)%2C also similar in C-terminus to PMG2_ECOLI P36942 probable phosphoglycerate mutase 2 (215 aa)%2C FASTA scores%3B opt: 212%2C E(): 2.5e-07 27.9%25 identity in 190 aa overlap%3B and to Rv2228 and Rv2419c;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2135c;product=Conserved protein;protein_id=CCP44910.1;transl_table=11
AL123456.3	EMBL	gene	2396008	2396838	.	-	.	ID=gene-Rv2136c;Name=Rv2136c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2136c
AL123456.3	EMBL	CDS	2396008	2396838	.	-	0	ID=cds-CCP44911.1;Parent=gene-Rv2136c;Dbxref=EnsemblGenomes-Gn:Rv2136c,EnsemblGenomes-Tr:CCP44911,GOA:P9WFF9,InterPro:IPR003824,NCBI_GP:CCP44911.1;Name=CCP44911.1;Note=Rv2136c%2C (MTCY270.32)%2C len: 276 aa. Possible conserved transmembrane protein%2C very similar to hypothetical Mycobacterium leprae protein Q49783. FASTA best: Q49783 B2126_C2_190 opt: 1023%2C E(): 0%3B (82.4%25 identity in 187 aa over lap) similar to BACA_ECOLI P31054 bacitracin resistance protein (273 aa) opt: 477%2C E(): 7e-26%2C (35.6%25 identity in 267 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2136c;product=Possible conserved transmembrane protein;protein_id=CCP44911.1;transl_table=11
AL123456.3	EMBL	gene	2396902	2397315	.	-	.	ID=gene-Rv2137c;Name=Rv2137c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2137c
AL123456.3	EMBL	CDS	2396902	2397315	.	-	0	ID=cds-CCP44912.1;Parent=gene-Rv2137c;Dbxref=EnsemblGenomes-Gn:Rv2137c,EnsemblGenomes-Tr:CCP44912,UniProtKB/TrEMBL:O06238,NCBI_GP:CCP44912.1;Name=CCP44912.1;Note=Rv2137c%2C (MTCY270.31)%2C len: 137 aa. Conserved hypothetical protein. C-terminus is very similar to hypothetical Mycobacterium leprae protein B2126_C2_188 (150 aa). FASTA best: Q49782 B2126_C2_188. (150 aa) opt: 469%2CE(): 9.6e-28%3B (77.2%25 identity in 101 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2137c;product=Conserved hypothetical protein;protein_id=CCP44912.1;transl_table=11
AL123456.3	EMBL	gene	2397330	2398406	.	+	.	ID=gene-Rv2138;Name=lppL;gbkey=Gene;gene=lppL;gene_biotype=protein_coding;locus_tag=Rv2138
AL123456.3	EMBL	CDS	2397330	2398406	.	+	0	ID=cds-CCP44913.1;Parent=gene-Rv2138;Dbxref=EnsemblGenomes-Gn:Rv2138,EnsemblGenomes-Tr:CCP44913,GOA:O06237,InterPro:IPR011042,UniProtKB/TrEMBL:O06237,NCBI_GP:CCP44913.1;Name=CCP44913.1;Note=Rv2138%2C (MTCY270.30c)%2C len: 358 aa. Probable lppL%2Cconserved lipoprotein%2C with appropriately placed lipoprotein signature (PS00013) strongly similar to hypothetical Mycobacterium leprae protein%2C Q49806. FASTA best: Q49806 B2126_F3_142. (298 aa) opt: 1495%2C E(): 0%3B (75.3%25 identity in 300 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppL;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2138;product=Probable conserved lipoprotein LppL;protein_id=CCP44913.1;transl_table=11
AL123456.3	EMBL	gene	2398720	2399793	.	+	.	ID=gene-Rv2139;Name=pyrD;gbkey=Gene;gene=pyrD;gene_biotype=protein_coding;locus_tag=Rv2139
AL123456.3	EMBL	CDS	2398720	2399793	.	+	0	ID=cds-CCP44914.1;Parent=gene-Rv2139;Dbxref=EnsemblGenomes-Gn:Rv2139,EnsemblGenomes-Tr:CCP44914,GOA:P9WHL1,InterPro:IPR001295,InterPro:IPR005719,InterPro:IPR012135,InterPro:IPR013785,NCBI_GP:CCP44914.1;Name=CCP44914.1;Note=Rv2139%2C (MTCY270.29c)%2C len: 357 aa. Probable pyrD%2Cdihydroorotate dehydrogenase %3B contains dihydroorotate dehydrogenase signatures 1 and 2 (PS00911%2C PS00912). FASTA best: PYRD_MYCLE P46727 dihydroorotate dehydrogenase (309 aa) opt: 1653%2C E(): 0%3B (82.6%25 identity in 304 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrD;inference=protein motif:PROSITE:PS00912;locus_tag=Rv2139;product=Probable dihydroorotate dehydrogenase PyrD;protein_id=CCP44914.1;transl_table=11
AL123456.3	EMBL	gene	2399798	2400328	.	-	.	ID=gene-Rv2140c;Name=TB18.6;gbkey=Gene;gene=TB18.6;gene_biotype=protein_coding;locus_tag=Rv2140c
AL123456.3	EMBL	CDS	2399798	2400328	.	-	0	ID=cds-CCP44915.1;Parent=gene-Rv2140c;Dbxref=EnsemblGenomes-Gn:Rv2140c,EnsemblGenomes-Tr:CCP44915,GOA:P9WFN1,InterPro:IPR005247,InterPro:IPR008914,PDB:4BEG,NCBI_GP:CCP44915.1;Name=CCP44915.1;Note=Rv2140c%2C (MTCY270.28)%2C len: 176 aa. TB18.6%2Cconserved protein%3B shows good similarity to hypothetical proteins from Streptomyces coelicolor (177 aa%3B 58%25 identity) >emb|CAC32358.1| (AL583945) and to 17.1 kDa Escherichia coli protein YbhB. FASTA best: YBHB_ECOLI P12994 hypothetical 17.1 kDa protein (158 aa) opt: 465 E( ): 2e-23%3B (46.2%25 identity in 156 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB18.6;locus_tag=Rv2140c;product=Conserved protein TB18.6;protein_id=CCP44915.1;transl_table=11
AL123456.3	EMBL	gene	2400376	2401722	.	-	.	ID=gene-Rv2141c;Name=Rv2141c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2141c
AL123456.3	EMBL	CDS	2400376	2401722	.	-	0	ID=cds-CCP44916.1;Parent=gene-Rv2141c;Dbxref=EnsemblGenomes-Gn:Rv2141c,EnsemblGenomes-Tr:CCP44916,GOA:L7N684,InterPro:IPR001261,InterPro:IPR002933,InterPro:IPR011650,UniProtKB/TrEMBL:L7N684,NCBI_GP:CCP44916.1;Name=CCP44916.1;Note=Rv2141c%2C (MTCY270.27)%2C len: 448 aa. Conserved protein. Shows some similarity to conserved hypothetical proteins and to acetylornithine deacetylase and succinyl-diaminopimelate desuccinylase and contains ArgE/dapE/ACY1/CPG2/yscS family signature 1 (PS00758). FASTA best: CBPS_YEAST P27614 carboxypeptidases precursor (576 aa) opt: 234%2C E(): 4.3e-08%3B (24.3%25 identity in 412 aa overlap). Previously named dapE2. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00758;locus_tag=Rv2141c;product=Conserved protein;protein_id=CCP44916.1;transl_table=11
AL123456.3	EMBL	gene	2401987	2402072	.	+	.	ID=gene-leuU;Name=leuU;gbkey=Gene;gene=leuU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2401987	2402072	.	+	.	ID=rna-leuU;Parent=gene-leuU;Note=codon recognized: CUC%3B leuU%2C tRNA-Leu%2C anticodon gag%2C length %3D 86;anticodon=(pos:2402020..2402022);gbkey=tRNA;gene=leuU;product=tRNA-Leu
AL123456.3	EMBL	exon	2401987	2402072	.	+	.	ID=exon-leuU-1;Parent=rna-leuU;Note=codon recognized: CUC%3B leuU%2C tRNA-Leu%2C anticodon gag%2C length %3D 86;anticodon=(pos:2402020..2402022);gbkey=tRNA;gene=leuU;product=tRNA-Leu
AL123456.3	EMBL	gene	2402193	2402510	.	-	.	ID=gene-Rv2142c;Name=parE2;gbkey=Gene;gene=parE2;gene_biotype=protein_coding;locus_tag=Rv2142c
AL123456.3	EMBL	CDS	2402193	2402510	.	-	0	ID=cds-CCP44917.1;Parent=gene-Rv2142c;Dbxref=EnsemblGenomes-Gn:Rv2142c,EnsemblGenomes-Tr:CCP44917,GOA:P9WHG5,InterPro:IPR007712,NCBI_GP:CCP44917.1;Name=CCP44917.1;Note=Rv2142c%2C (MTCY270.26)%2C len: 105 aa. Possible parE2%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2142A (See Pandey and Gerdes%2C 2005).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=parE2;locus_tag=Rv2142c;product=Possible toxin ParE2;protein_id=CCP44917.1;transl_table=11
AL123456.3	EMBL	gene	2402507	2402722	.	-	.	ID=gene-Rv2142A;Name=parD2;gbkey=Gene;gene=parD2;gene_biotype=protein_coding;locus_tag=Rv2142A
AL123456.3	EMBL	CDS	2402507	2402722	.	-	0	ID=cds-CCP44918.1;Parent=gene-Rv2142A;Dbxref=EnsemblGenomes-Gn:Rv2142A,EnsemblGenomes-Tr:CCP44918,GOA:P9WJ75,InterPro:IPR013406,NCBI_GP:CCP44918.1;Name=CCP44918.1;Note=Rv2142A%2C len: 71 aa. Possible parD2%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv2142c (See Pandey and Gerdes%2C 2005).;gbkey=CDS;gene=parD2;locus_tag=Rv2142A;product=Possible antitoxin ParD2;protein_id=CCP44918.1;transl_table=11
AL123456.3	EMBL	gene	2402977	2404035	.	+	.	ID=gene-Rv2143;Name=Rv2143;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2143
AL123456.3	EMBL	CDS	2402977	2404035	.	+	0	ID=cds-CCP44919.1;Parent=gene-Rv2143;Dbxref=EnsemblGenomes-Gn:Rv2143,EnsemblGenomes-Tr:CCP44919,GOA:O06232,InterPro:IPR000836,InterPro:IPR029057,UniProtKB/TrEMBL:O06232,NCBI_GP:CCP44919.1;Name=CCP44919.1;Note=Rv2143%2C (MTCY270.25c)%2C len: 352 aa. Conserved hypothetical protein%2C strongly similar to two hypothetical mycobacterial proteins Rv2030c 2.1e-50 and Rv0571c from position 120 (Q50819%3B Q50111). FASTA best: Q50819 opt: 882%2CE() 0%3B (61.1%25 identity in 226 aa overlap). Also similar to AL021942|MTV039_9 (443 aa)%2C FASTA scores: opt: 592%2C E(): 5e-30%3B 46.9%25 identity in 224 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2143;product=Conserved hypothetical protein;protein_id=CCP44919.1;transl_table=11
AL123456.3	EMBL	gene	2404165	2404521	.	-	.	ID=gene-Rv2144c;Name=Rv2144c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2144c
AL123456.3	EMBL	CDS	2404165	2404521	.	-	0	ID=cds-CCP44920.1;Parent=gene-Rv2144c;Dbxref=EnsemblGenomes-Gn:Rv2144c,EnsemblGenomes-Tr:CCP44920,GOA:O06231,UniProtKB/TrEMBL:O06231,NCBI_GP:CCP44920.1;Name=CCP44920.1;Note=Rv2144c%2C (MTCY270.24)%2C len: 118 aa. Probable transmembrane protein. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2144c;product=Probable transmembrane protein;protein_id=CCP44920.1;transl_table=11
AL123456.3	EMBL	gene	2404616	2405398	.	-	.	ID=gene-Rv2145c;Name=wag31;gbkey=Gene;gene=wag31;gene_biotype=protein_coding;gene_synonym=ag84;locus_tag=Rv2145c
AL123456.3	EMBL	CDS	2404616	2405398	.	-	0	ID=cds-CCP44921.1;Parent=gene-Rv2145c;Dbxref=EnsemblGenomes-Gn:Rv2145c,EnsemblGenomes-Tr:CCP44921,GOA:P9WMU1,InterPro:IPR007793,InterPro:IPR019933,NCBI_GP:CCP44921.1;Name=CCP44921.1;Note=Rv2145c%2C (MTCY270.23)%2C len: 260 aa. Wag31 (alternate gene name: ag84). Function unknown but corresponds to antigen 84 of Mycobacterium tuberculosis (wag31) (see Hermans et al.%2C 1995). Predicted to contain significant amount of coiled coil structure. Some similarity to Rv1682 and Rv2927c. FASTA best: AG84_MYCTU P46816 antigen 84. Wag31|Rv2145c and PbpB|Rv2163c have been shown to interact%3B cleavage of PbpB|Rv2163c by Rv2869c under conditions of oxidative stress is prevented by Wag31|Rv2145c (See Mukherjee et al.%2C 2009).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=wag31;locus_tag=Rv2145c;product=Diviva family protein Wag31;protein_id=CCP44921.1;transl_table=11
AL123456.3	EMBL	gene	2405666	2405956	.	-	.	ID=gene-Rv2146c;Name=Rv2146c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2146c
AL123456.3	EMBL	CDS	2405666	2405956	.	-	0	ID=cds-CCP44922.1;Parent=gene-Rv2146c;Dbxref=EnsemblGenomes-Gn:Rv2146c,EnsemblGenomes-Tr:CCP44922,GOA:O06230,InterPro:IPR003425,UniProtKB/TrEMBL:O06230,NCBI_GP:CCP44922.1;Name=CCP44922.1;Note=Rv2146c%2C (MTCY270.22)%2C len: 96 aa. Possible conserved transmembrane protein%2C orthologs present in M. leprae%2C ML0921 (96 aa) and Streptomyces coelicolor. Second start taken GTG alternative upstream but much less probable in TBParse. FASTA best: Q44935 similar to a hypothetical integral membrane prot EIN (97 aa) opt: 105%2C E(): 0.093%3B (25.3%25 identity in 87 aa overlap). >emb|CAC31302.1| (AL583920) possible membrane protein ML0921 [Mycobacterium leprae] E(): 5e-32 (76%25 identity in 96 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2146c;product=Possible conserved transmembrane protein;protein_id=CCP44922.1;transl_table=11
AL123456.3	EMBL	gene	2406118	2406843	.	-	.	ID=gene-Rv2147c;Name=Rv2147c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2147c
AL123456.3	EMBL	CDS	2406118	2406843	.	-	0	ID=cds-CCP44923.1;Parent=gene-Rv2147c;Dbxref=EnsemblGenomes-Gn:Rv2147c,EnsemblGenomes-Tr:CCP44923,GOA:P9WGJ5,InterPro:IPR007561,InterPro:IPR023052,NCBI_GP:CCP44923.1;Name=CCP44923.1;Note=Rv2147c%2C (MTCY270.21)%2C len: 241 aa. Conserved hypothetical protein%2C similar to conserved hypothetical proteins in Mycobacterium leprae ML0920 (210 aa) and Streptomyces coelicolor. FASTA scores: >emb|CAC31301.1| (AL583920) hypothetical protein ML0920 hypothetical protein (210 aa) opt: 1242%2C E(): 5.7e-74%3B 83.486%25 identity in 218 aa overlap. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2147c;product=Conserved hypothetical protein;protein_id=CCP44923.1;transl_table=11
AL123456.3	EMBL	gene	2406840	2407616	.	-	.	ID=gene-Rv2148c;Name=Rv2148c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2148c
AL123456.3	EMBL	CDS	2406840	2407616	.	-	0	ID=cds-CCP44924.1;Parent=gene-Rv2148c;Dbxref=EnsemblGenomes-Gn:Rv2148c,EnsemblGenomes-Tr:CCP44924,InterPro:IPR001608,InterPro:IPR011078,InterPro:IPR029066,NCBI_GP:CCP44924.1;Name=CCP44924.1;Note=Rv2148c%2C (MTCY270.20)%2C len: 258 aa. Conserved protein%3B should belong to the YGGS/YBL036C/F09E5.8 family. FASTA best: AB003132|AB003132_5 Corynebacterium glutamicum gene (221 aa) opt: 440%2C E(): 2.3e-23%3B 42.8%25 identity in 236 aa overlap%3B and YPI1_VIBAL P52055 hypothetical protein in pilt-proc intergenic region in Vibrio alginolyticus. opt: 266%2C E(): 1.8e-11%3B 27.9%25 identity in 244 aa overlap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2148c;product=Conserved protein;protein_id=CCP44924.1;transl_table=11
AL123456.3	EMBL	gene	2407622	2408374	.	-	.	ID=gene-Rv2149c;Name=yfiH;gbkey=Gene;gene=yfiH;gene_biotype=protein_coding;locus_tag=Rv2149c
AL123456.3	EMBL	CDS	2407622	2408374	.	-	0	ID=cds-CCP44925.1;Parent=gene-Rv2149c;Dbxref=EnsemblGenomes-Gn:Rv2149c,EnsemblGenomes-Tr:CCP44925,GOA:P9WKD5,InterPro:IPR003730,InterPro:IPR011324,NCBI_GP:CCP44925.1;Name=CCP44925.1;Note=Rv2149c%2C (MTCY270.19)%2C len: 250 aa. YfiH%3B corresponds to 25.3 kDa YfiH protein in ftsZ 3' region of Streptomyces griseus%2C and to YfiH proteins in other bacteria. Belongs to UPF0124 Family. FASTA best: YFIH_STRGR P45496%2C (246 aa) opt: 722%2C E(): 1.9e-37%3B (49.4%25 identity in 245 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yfiH;locus_tag=Rv2149c;product=Conserved protein YfiH;protein_id=CCP44925.1;transl_table=11
AL123456.3	EMBL	gene	2408385	2409524	.	-	.	ID=gene-Rv2150c;Name=ftsZ;gbkey=Gene;gene=ftsZ;gene_biotype=protein_coding;locus_tag=Rv2150c
AL123456.3	EMBL	CDS	2408385	2409524	.	-	0	ID=cds-CCP44926.1;Parent=gene-Rv2150c;Dbxref=EnsemblGenomes-Gn:Rv2150c,EnsemblGenomes-Tr:CCP44926,GOA:P9WN95,InterPro:IPR000158,InterPro:IPR003008,InterPro:IPR008280,InterPro:IPR018316,InterPro:IPR020805,InterPro:IPR024757,PDB:1RLU,PDB:1RQ2,PDB:1RQ7,PDB:2Q1X,PDB:2Q1Y,PDB:4KWE,NCBI_GP:CCP44926.1;Name=CCP44926.1;Note=Rv2150c%2C (MTCY270.18)%2C len: 379 aa. FtsZ%2C cell division protein (see Dziadek et al.%2C 2002). Contains FtsZ protein signature 2 (PS01135). FASTA best: FTSZ_STRCO P45500 cell division protein FtsZ (399 aa) opt: 1674%2C E(): 0%3B (77.3%25 identity in 339 aa overlap). FtsW|Rv2154c interacts with PbpB|Rv2163c and FtsZ|RvRv2150c (See Datta et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ftsZ;inference=protein motif:PROSITE:PS01135;locus_tag=Rv2150c;product=Cell division protein FtsZ;protein_id=CCP44926.1;transl_table=11
AL123456.3	EMBL	gene	2409697	2410641	.	-	.	ID=gene-Rv2151c;Name=ftsQ;gbkey=Gene;gene=ftsQ;gene_biotype=protein_coding;locus_tag=Rv2151c
AL123456.3	EMBL	CDS	2409697	2410641	.	-	0	ID=cds-CCP44927.1;Parent=gene-Rv2151c;Dbxref=EnsemblGenomes-Gn:Rv2151c,EnsemblGenomes-Tr:CCP44927,GOA:P9WNA1,InterPro:IPR005548,InterPro:IPR013685,InterPro:IPR026579,NCBI_GP:CCP44927.1;Name=CCP44927.1;Note=Rv2151c%2C (MTCY270.17)%2C len: 314 aa. Possible ftsQ%2Ccell division protein%2C with some homology to FTSQ_STRGR|P45503 cell division protein ftsq homolog from Streptomyces griseus (208 aa)%2C FASTA scores: opt: 204%2C E(): 4e-05%3B (30.6%25 identity in 193 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ftsQ;locus_tag=Rv2151c;product=Possible cell division protein FtsQ;protein_id=CCP44927.1;transl_table=11
AL123456.3	EMBL	gene	2410638	2412122	.	-	.	ID=gene-Rv2152c;Name=murC;gbkey=Gene;gene=murC;gene_biotype=protein_coding;locus_tag=Rv2152c
AL123456.3	EMBL	CDS	2410638	2412122	.	-	0	ID=cds-CCP44928.1;Parent=gene-Rv2152c;Dbxref=EnsemblGenomes-Gn:Rv2152c,EnsemblGenomes-Tr:CCP44928,GOA:P9WJL7,InterPro:IPR000713,InterPro:IPR004101,InterPro:IPR005758,InterPro:IPR013221,InterPro:IPR016040,NCBI_GP:CCP44928.1;Name=CCP44928.1;Note=Rv2152c%2C (MTCY270.16)%2C len: 494 aa. Probable murC%2CUDP-N-acetylmuramate-alanine ligase (see citation below)%2Csimilar to others e.g. MURC_ECOLI|P17952 (491 aa)%2C FASTA scores: opt: 764%2C E(): 0%2C (36.9%25 identity in 474 aa overlap)%3B etc.;gbkey=CDS;gene=murC;locus_tag=Rv2152c;product=Probable UDP-N-acetylmuramate-alanine ligase MurC;protein_id=CCP44928.1;transl_table=11
AL123456.3	EMBL	gene	2412119	2413351	.	-	.	ID=gene-Rv2153c;Name=murG;gbkey=Gene;gene=murG;gene_biotype=protein_coding;locus_tag=Rv2153c
AL123456.3	EMBL	CDS	2412119	2413351	.	-	0	ID=cds-CCP44929.1;Parent=gene-Rv2153c;Dbxref=EnsemblGenomes-Gn:Rv2153c,EnsemblGenomes-Tr:CCP44929,GOA:P9WJK9,InterPro:IPR004276,InterPro:IPR006009,InterPro:IPR007235,NCBI_GP:CCP44929.1;Name=CCP44929.1;Note=Rv2153c%2C (MTCY270.15)%2C len: 410 aa. Probable murG%2C UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase (see citation below)%2C similar to others e.g. MURG_BACSU[P37585 murg protein from Bacilus subtilis (363 aa)%2C FASTA score: opt: 494%2C E(): 1.1e-20%2C (27.9%25 identity in 365 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=murG;locus_tag=Rv2153c;product=Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG;protein_id=CCP44929.1;transl_table=11
AL123456.3	EMBL	gene	2413348	2414922	.	-	.	ID=gene-Rv2154c;Name=ftsW;gbkey=Gene;gene=ftsW;gene_biotype=protein_coding;locus_tag=Rv2154c
AL123456.3	EMBL	CDS	2413348	2414922	.	-	0	ID=cds-CCP44930.1;Parent=gene-Rv2154c;Dbxref=EnsemblGenomes-Gn:Rv2154c,EnsemblGenomes-Tr:CCP44930,GOA:P9WN97,InterPro:IPR001182,InterPro:IPR013437,InterPro:IPR018365,NCBI_GP:CCP44930.1;Name=CCP44930.1;Note=Rv2154c%2C (MTCY270.14)%2C len: 524 aa. Probable ftsW%2Ccell division protein%2C related to MTCY10H4.17c%2C 3.2e-17. FASTA best: SP5E_BACSU P07373 stage V sporulation protein E (366 aa) opt: 755%2C E(): 1.6e-33%3B (38.4%25 identity in 357 aa overlap). FtsW|Rv2154c interacts with PbpB|Rv2163c and FtsZ|RvRv2150c (See Datta et al.%2C 2006).;gbkey=CDS;gene=ftsW;locus_tag=Rv2154c;product=FtsW-like protein FtsW;protein_id=CCP44930.1;transl_table=11
AL123456.3	EMBL	gene	2414934	2416394	.	-	.	ID=gene-Rv2155c;Name=murD;gbkey=Gene;gene=murD;gene_biotype=protein_coding;locus_tag=Rv2155c
AL123456.3	EMBL	CDS	2414934	2416394	.	-	0	ID=cds-CCP44931.1;Parent=gene-Rv2155c;Dbxref=EnsemblGenomes-Gn:Rv2155c,EnsemblGenomes-Tr:CCP44931,GOA:P9WJL5,InterPro:IPR004101,InterPro:IPR005762,InterPro:IPR013221,InterPro:IPR016040,NCBI_GP:CCP44931.1;Name=CCP44931.1;Note=Rv2155c%2C (MTCY270.13)%2C len: 486 aa. Probable murD%2CUDP-N-acetylmuramoylalanine-D-glutamate ligase (see citation below)%2C similar to others e.g. MURD_BACSU|Q03522 (451 aa)%2C FASTA scores: opt: 534%2C E(): 2.7e-25%2C (28.8%25 identity in 483 aa overlap)%3B etc. Contains PS01011 Folylpolyglutamate synthase signature 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=murD;inference=protein motif:PROSITE:PS01011;locus_tag=Rv2155c;product=Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;protein_id=CCP44931.1;transl_table=11
AL123456.3	EMBL	gene	2416396	2417475	.	-	.	ID=gene-Rv2156c;Name=murX;gbkey=Gene;gene=murX;gene_biotype=protein_coding;locus_tag=Rv2156c
AL123456.3	EMBL	CDS	2416396	2417475	.	-	0	ID=cds-CCP44932.1;Parent=gene-Rv2156c;Dbxref=EnsemblGenomes-Gn:Rv2156c,EnsemblGenomes-Tr:CCP44932,GOA:P9WMW7,InterPro:IPR000715,InterPro:IPR003524,InterPro:IPR018480,NCBI_GP:CCP44932.1;Name=CCP44932.1;Note=Rv2156c%2C (MTCY270.12)%2C len: 359 aa. Probable murX%2Cphospho-N-acetylmuramoyl-pentappeptidetransferase (see citation below)%2C similar to others e.g.MRAY_ECOLI|P15876 (360 aa)%2C FASTA scores: opt: 572%2C E(): 2.7e-29%2C (35.8%25 identity in 344 aa overlap)%3B etc.;gbkey=CDS;gene=murX;locus_tag=Rv2156c;product=Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX;protein_id=CCP44932.1;transl_table=11
AL123456.3	EMBL	gene	2417472	2419004	.	-	.	ID=gene-Rv2157c;Name=murF;gbkey=Gene;gene=murF;gene_biotype=protein_coding;locus_tag=Rv2157c
AL123456.3	EMBL	CDS	2417472	2419004	.	-	0	ID=cds-CCP44933.1;Parent=gene-Rv2157c;Dbxref=EnsemblGenomes-Gn:Rv2157c,EnsemblGenomes-Tr:CCP44933,GOA:P9WJL1,InterPro:IPR000713,InterPro:IPR004101,InterPro:IPR005863,InterPro:IPR013221,NCBI_GP:CCP44933.1;Name=CCP44933.1;Note=Rv2157c%2C (MTCY270.11)%2C len: 510 aa. Probable murF%2CUDP-N-acetylmuramoylalanyl-D-glutamyl-2%2C 6-diaminopimelate-D-alanyl-D-alanyl ligase (UDP-murnac-pentapeptide synthetase) (see citation below)%2C also related to other Mycobacterium tuberculosis mur gene products. FASTA best: MURF_ECOLI|P11880 (452 aa)%2Copt: 515%2C E(): 2.6e-24%2C (31.9%25 identity in 511 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=murF;locus_tag=Rv2157c;product=Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2%2C 6-diaminopimelate-D-alanyl-D-alanyl ligase MurF;protein_id=CCP44933.1;transl_table=11
AL123456.3	EMBL	gene	2419001	2420608	.	-	.	ID=gene-Rv2158c;Name=murE;gbkey=Gene;gene=murE;gene_biotype=protein_coding;locus_tag=Rv2158c
AL123456.3	EMBL	CDS	2419001	2420608	.	-	0	ID=cds-CCP44934.1;Parent=gene-Rv2158c;Dbxref=EnsemblGenomes-Gn:Rv2158c,EnsemblGenomes-Tr:CCP44934,GOA:P9WJL3,InterPro:IPR000713,InterPro:IPR004101,InterPro:IPR005761,InterPro:IPR013221,PDB:2WTZ,PDB:2XJA,NCBI_GP:CCP44934.1;Name=CCP44934.1;Note=Rv2158c%2C (MTCY270.10)%2C len: 535 aa. Probable murE%2CUDP-N-acetylmuramoylalanyl-D-glutamate-2%2C 6-diaminopimelate ligase%3B UDP-N-acetylmuramyl-tripeptide synthetase (see citation below)%2C also related to other Mycobacterium tuberculosis mur gene products. FASTA best: MURE_BACSU|Q03523 (494 aa)%2C opt: 1020%2C E(): 0%2C (40.1%25 identity in 476 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=murE;locus_tag=Rv2158c;product=Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2%2C6-diaminopimelate ligase MurE;protein_id=CCP44934.1;transl_table=11
AL123456.3	EMBL	gene	2420631	2421665	.	-	.	ID=gene-Rv2159c;Name=Rv2159c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2159c
AL123456.3	EMBL	CDS	2420631	2421665	.	-	0	ID=cds-CCP44935.1;Parent=gene-Rv2159c;Dbxref=EnsemblGenomes-Gn:Rv2159c,EnsemblGenomes-Tr:CCP44935,GOA:O06218,InterPro:IPR003779,InterPro:IPR004675,InterPro:IPR029032,UniProtKB/TrEMBL:O06218,NCBI_GP:CCP44935.1;Name=CCP44935.1;Note=Rv2159c%2C (MTCY270.09)%2C len: 344 aa. Conserved protein%3B some similarity to hypothetical protein from Streptomyces coelicolor SC1A6.09c (337 aa%2C 29%25 identity). Smith-Waterman scores: >pir||T28690 hypothetical protein -Streptomyces coelicolor >gi|3127841|emb|CAA18907.1| (AL023496) Expect %3D 2e-18. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2159c;product=Conserved protein;protein_id=CCP44935.1;transl_table=11
AL123456.3	EMBL	gene	2421643	2422278	.	-	.	ID=gene-Rv2160A;Name=Rv2160A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2160A
AL123456.3	EMBL	CDS	2421643	2422278	.	-	0	ID=cds-CCP44936.1;Parent=gene-Rv2160A;Dbxref=EnsemblGenomes-Gn:Rv2160A,EnsemblGenomes-Tr:CCP44936,GOA:L0TBP1,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:L0TBP1,NCBI_GP:CCP44936.1;Name=CCP44936.1;Note=Rv2160A%2C len: 211 aa. Conserved hypothetical protein%2C possibly a TetR-family transcriptional regulator%2Csimilar to N-terminal half of AL512667_12|Q9AD73|SCK31.01c putative TetR-family transcriptional regulator from Streptomyces coelicolor (200 aa)%2C FASTA scores: opt: 285%2CE(): 1.4e-08%2C (51.042%25 identity in 96 aa overlap). Next gene%2C Rv2160c%2C is similar to C-terminal half of 2SCK31.01c suggesting possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2160A;product=Conserved hypothetical protein;protein_id=CCP44936.1;transl_table=11
AL123456.3	EMBL	gene	2421662	2422003	.	-	.	ID=gene-Rv2160c;Name=Rv2160c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2160c
AL123456.3	EMBL	CDS	2421662	2422003	.	-	0	ID=cds-CCP44937.1;Parent=gene-Rv2160c;Dbxref=EnsemblGenomes-Gn:Rv2160c,EnsemblGenomes-Tr:CCP44937,GOA:Q79FG9,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:Q79FG9,NCBI_GP:CCP44937.1;Name=CCP44937.1;Note=Rv2160c%2C (MTCY270.08)%2C len: 113 aa. Conserved hypothetical protein%2C possibly a TetR-family transcriptional regulator%2C similar to C-terminal half of AL512667_12|Q9AD73|SCK31.01c putative TetR-family transcriptional regulator from Streptomyces coelicolor (200 aa)%2C while Rv2160A is similar to the N-terminal half of 2SCK31.01c. This suggests possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2160c;product=Conserved hypothetical protein;protein_id=CCP44937.1;transl_table=11
AL123456.3	EMBL	gene	2422271	2423137	.	-	.	ID=gene-Rv2161c;Name=Rv2161c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2161c
AL123456.3	EMBL	CDS	2422271	2423137	.	-	0	ID=cds-CCP44938.1;Parent=gene-Rv2161c;Dbxref=EnsemblGenomes-Gn:Rv2161c,EnsemblGenomes-Tr:CCP44938,GOA:O06216,InterPro:IPR011251,InterPro:IPR019921,UniProtKB/TrEMBL:O06216,NCBI_GP:CCP44938.1;Name=CCP44938.1;Note=Rv2161c%2C (MTCY270.07)%2C len: 288 aa. Conserved protein%3B shows some similarity to protein involved in lincomycin production and to other M. tuberculosis proteins e.g. Rv0953c%2C Rv0791c%2C Rv0132c%2C Rv2951c%2C Rv1855c. FASTA best: Q54379 (78-11) lincomycin production genes (295 aa) opt: 243%2C E(): 2.4e-09%3B (29.5%25 identity in 285 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2161c;product=Conserved protein;protein_id=CCP44938.1;transl_table=11
AL123456.3	EMBL	gene	2423240	2424838	.	-	.	ID=gene-Rv2162c;Name=PE_PGRS38;gbkey=Gene;gene=PE_PGRS38;gene_biotype=protein_coding;locus_tag=Rv2162c
AL123456.3	EMBL	CDS	2423240	2424838	.	-	0	ID=cds-CCP44939.1;Parent=gene-Rv2162c;Dbxref=EnsemblGenomes-Gn:Rv2162c,EnsemblGenomes-Tr:CCP44939,InterPro:IPR000084,UniProtKB/TrEMBL:L7N6A1,NCBI_GP:CCP44939.1;Name=CCP44939.1;Note=Rv2162c%2C (MTCY270.06)%2C len: 532 aa. PE_PGRS38%2CMember of M. tuberculosis PE_PGRS family (see citations below). FASTA score: Y03A_MYCTU Q 10637 hypothetical glycine-rich 49.6 kDa protein (603 aa) op t: 1798 z-score: 1220.0 E(): 0%3B (55.4%25 identity in 590 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS38;locus_tag=Rv2162c;product=PE-PGRS family protein PE_PGRS38;protein_id=CCP44939.1;transl_table=11
AL123456.3	EMBL	gene	2425048	2427087	.	-	.	ID=gene-Rv2163c;Name=pbpB;gbkey=Gene;gene=pbpB;gene_biotype=protein_coding;gene_synonym=ftsI;locus_tag=Rv2163c
AL123456.3	EMBL	CDS	2425048	2427087	.	-	0	ID=cds-CCP44940.1;Parent=gene-Rv2163c;Dbxref=EnsemblGenomes-Gn:Rv2163c,EnsemblGenomes-Tr:CCP44940,GOA:L0T911,InterPro:IPR001460,InterPro:IPR005311,InterPro:IPR012338,NCBI_GP:CCP44940.1;Name=CCP44940.1;Note=Rv2163c%2C (MTCY270.05)%2C len: 679 aa. Probable pbpB%2Cpenicillin-binding membrane protein%2C similar to many bacterial PBP2 proteins e.g. P11882|PBP2_NEIME|PENA|NMA2072|NMB0413 penicillin-binding protein 2 (pbp-2) from Neisseria meningitidis (serogroups a and B) (581 aa)%2C FASTA scores: opt: 665%2C E(): 1.6e-31%2C(33.2%25 identity in 591 aa overlap)%3B etc. Also similar to Rv0016c and Rv2864c from Mycobacterium tuberculosis (2.8e-10). Contains PS00017 possible ATP/GTP-binding site motif A (P-loop) near C-terminus. FASTA best: PBP2_NEIME P11882 penicillin-binding protein 2 (pbp-2). (581 aa) opt: 665%2C E(): 1.6e-31%3B (33.2%25 identity in 591 aa overlap). FtsW|Rv2154c interacts with PbpB|Rv2163c and FtsZ|RvRv2150c (See Datta et al.%2C 2006). Cleavage of PbpB|Rv2163c by Rv2869c under conditions of oxidative stress is prevented by Wag31|Rv2145c (See Mukherjee et al.%2C 2009).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pbpB;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2163c;product=Probable penicillin-binding membrane protein PbpB;protein_id=CCP44940.1;transl_table=11
AL123456.3	EMBL	gene	2427084	2428238	.	-	.	ID=gene-Rv2164c;Name=Rv2164c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2164c
AL123456.3	EMBL	CDS	2427084	2428238	.	-	0	ID=cds-CCP44941.1;Parent=gene-Rv2164c;Dbxref=EnsemblGenomes-Gn:Rv2164c,EnsemblGenomes-Tr:CCP44941,GOA:O06213,UniProtKB/TrEMBL:O06213,NCBI_GP:CCP44941.1;Name=CCP44941.1;Note=Rv2164c%2C (MTCY270.04)%2C len: 384 aa. Probable pro-rich conserved membrane protein%2C equivalent to ML0907|AL022602 putative conserved membrane protein from Mycobacterium leprae (377 aa) (AL022602)%2C FASTA scores: opt: 1495%2C E(): 1.7e-56%2C (62.217%25 identity in 397 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2164c;product=Probable conserved proline rich membrane protein;protein_id=CCP44941.1;transl_table=11
AL123456.3	EMBL	gene	2428235	2429425	.	-	.	ID=gene-Rv2165c;Name=Rv2165c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2165c
AL123456.3	EMBL	CDS	2428235	2429425	.	-	0	ID=cds-CCP44942.1;Parent=gene-Rv2165c;Dbxref=EnsemblGenomes-Gn:Rv2165c,EnsemblGenomes-Tr:CCP44942,GOA:P9WJP1,InterPro:IPR002903,InterPro:IPR023397,InterPro:IPR029063,NCBI_GP:CCP44942.1;Name=CCP44942.1;Note=Rv2165c%2C (MTCY270.03)%2C len: 396 aa. Conserved protein%3B shows strong similarity to several hypothetical bacterial proteins but has extra 80 aa residues at N-terminus FASTA best: YLXA_BACSU Q07876 hypothetical 35.3 kDa protein in ftsl (311 aa) opt: 781%2C E(): 0%3B (45.6%25 identity in 296 aa overlap)%2C belongs to the YABC (E.coli)%2CYLXA (B.subtilis) family;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2165c;product=Conserved protein;protein_id=CCP44942.1;transl_table=11
AL123456.3	EMBL	gene	2429427	2429858	.	-	.	ID=gene-Rv2166c;Name=Rv2166c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2166c
AL123456.3	EMBL	CDS	2429427	2429858	.	-	0	ID=cds-CCP44943.1;Parent=gene-Rv2166c;Dbxref=EnsemblGenomes-Gn:Rv2166c,EnsemblGenomes-Tr:CCP44943,GOA:P9WJN9,InterPro:IPR003444,InterPro:IPR020603,NCBI_GP:CCP44943.1;Name=CCP44943.1;Note=Rv2166c%2C (MTCY270.02)%2C len: 143 aa. Conserved protein%3B shows strong similarity to several hypothetical bacterial proteins such as YLLB_BACSU P55343. Is equivalent to Mycobacterium leprae hypothetical protein ML0905 (143 aa%2C 92%25 identity) MLCB268.11c >sp|O69561|YL66_MYCLE hypothetical 16.1 KDA protein ML0905 >gi|3080482|emb|CAA18677.1|(AL022602) >gi|13092975|emb|CAC31286.1|(AL583920). FASTA scores: ML0905|ML0905 conserved hypothetical protein (143 aa) opt: 873%2C E(): 3.1e-52%3B 92.254%25 identity in 142 aa overlap%3B YLLB_BACSU P55343 hypothetical 16.6 kDa protein (143 aa) opt: 340%2C E(): 3.6e-17%3B (35.0%25 identity in 143 aa overlap). Belongs to the YABB (E.coli)%2C YLLB (B.subtilis)%2C MG221 (M.genitalium) family;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2166c;product=Conserved protein;protein_id=CCP44943.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2430117	2431471	.	-	.	ID=id-AL123456.3:2430117..2431471;Note=IS6110-6%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-6
AL123456.3	EMBL	repeat_region	2430117	2430144	.	-	.	ID=id-AL123456.3:2430117..2430144;Note=28 bp Inverted repeat at the left end of IS6110%3B GAGTCTCCGGACTCACCGGGGCGGTTCA;gbkey=repeat_region
AL123456.3	EMBL	gene	2430159	2431145	.	-	.	ID=gene-Rv2167c;Name=Rv2167c;end_range=2431145,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2167c;partial=true
AL123456.3	EMBL	CDS	2430159	2431145	.	-	0	ID=cds-CCP44944.1;Parent=gene-Rv2167c;Dbxref=EnsemblGenomes-Gn:Rv2167c,EnsemblGenomes-Tr:CCP44944,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP44944.1;Name=CCP44944.1;Note=Rv2167c%2C (MTCY270.01)%2C len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2167c and Rv2168c%2C the sequence UUUUAAAG (directly upstream of Rv2167c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (- 18 aa).;end_range=2431145,.;gbkey=CDS;locus_tag=Rv2167c;partial=true;product=Probable transposase;protein_id=CCP44944.1;transl_table=11
AL123456.3	EMBL	gene	2431094	2431420	.	-	.	ID=gene-Rv2168c;Name=Rv2168c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2168c
AL123456.3	EMBL	CDS	2431094	2431420	.	-	0	ID=cds-CCP44945.1;Parent=gene-Rv2168c;Dbxref=EnsemblGenomes-Gn:Rv2168c,EnsemblGenomes-Tr:CCP44945,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP44945.1;Name=CCP44945.1;Note=Rv2168c%2C (MTV021.01c)%2C len: 108 aa. Putative transposase for IS6110 (fragment)%2C identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion element IS6110 hypothetical 12.0 kDa protein (108 aa)%2C fasta scores: E(): 1.4e-43%2C(100.00%25 identity in 108 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2167c and Rv2168c%2C the sequence UUUUAAAG (directly upstream of Rv2167c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv2168c;product=Putative transposase for insertion sequence element IS6110 (fragment);protein_id=CCP44945.1;transl_table=11
AL123456.3	EMBL	repeat_region	2431444	2431471	.	-	.	ID=id-AL123456.3:2431444..2431471;Note=28 bp Inverted repeat at the right end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	2431565	2431969	.	-	.	ID=gene-Rv2169c;Name=Rv2169c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2169c
AL123456.3	EMBL	CDS	2431565	2431969	.	-	0	ID=cds-CCP44946.1;Parent=gene-Rv2169c;Dbxref=EnsemblGenomes-Gn:Rv2169c,EnsemblGenomes-Tr:CCP44946,GOA:O53503,InterPro:IPR021401,UniProtKB/TrEMBL:O53503,NCBI_GP:CCP44946.1;Name=CCP44946.1;Note=Rv2169c%2C (MTV021.02c)%2C len: 134 aa. Probable conserved transmembrane protein%2C with orthologs in M. leprae%2C ML0904 probable membrane protein (134 aa)%2C and Streptomyces coelicolor. FASTA scores with ML0904%2C opt: 767%2C E(): 5.1e-43%3B 86.567%25 identity in 134 aa overlap. emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1| (AL583920). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2169c;product=Probable conserved transmembrane protein;protein_id=CCP44946.1;transl_table=11
AL123456.3	EMBL	gene	2432235	2432855	.	+	.	ID=gene-Rv2170;Name=Rv2170;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2170
AL123456.3	EMBL	CDS	2432235	2432855	.	+	0	ID=cds-CCP44947.1;Parent=gene-Rv2170;Dbxref=EnsemblGenomes-Gn:Rv2170,EnsemblGenomes-Tr:CCP44947,GOA:O53504,InterPro:IPR000182,InterPro:IPR013653,InterPro:IPR016181,UniProtKB/TrEMBL:O53504,NCBI_GP:CCP44947.1;Name=CCP44947.1;Note=Rv2170%2C (MTV021.03)%2C len: 206 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005. Equivalent to hypothetical protein ML0903 (210 aa) from Mycobacterium leprae. FASTA scores: ML0903 conserved hypothetical protein (210 aa) opt: 1045%2C E(): 9.1e-57%3B 77.143%25 identity in 210 aa overlap. >emb|CAA18679.1| (AL022602) >gi|13092973|emb|CAC31284.1| (AL583920). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2170;product=GCN5-related N-acetyltransferase;protein_id=CCP44947.1;transl_table=11
AL123456.3	EMBL	gene	2432951	2433634	.	+	.	ID=gene-Rv2171;Name=lppM;gbkey=Gene;gene=lppM;gene_biotype=protein_coding;locus_tag=Rv2171
AL123456.3	EMBL	CDS	2432951	2433634	.	+	0	ID=cds-CCP44948.1;Parent=gene-Rv2171;Dbxref=EnsemblGenomes-Gn:Rv2171,EnsemblGenomes-Tr:CCP44948,GOA:O53505,InterPro:IPR021499,UniProtKB/TrEMBL:O53505,NCBI_GP:CCP44948.1;Name=CCP44948.1;Note=Rv2171%2C (MTV021.04)%2C len: 227 aa. Probable lppM%2Cconserved lipoprotein%3B contains putative signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Has hydrophobic stretch at C-terminus and also contains PS00225 Crystallins beta and gamma 'Greek key' motif signature. Unknown but equivalent to Mycobacterium leprae lipoprotein ML0902 (239 aa). FASTA scores: opt: 1083%2C E(): 2.4e-56%3B 75.446%25 identity in 224 aa overlap (5-227:16-239) >emb|CAA18680.1| (AL022602) >gi|13092972|emb|CAC31283.1| (AL583920). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppM;inference=protein motif:PROSITE:PS00225;locus_tag=Rv2171;product=Probable conserved lipoprotein LppM;protein_id=CCP44948.1;transl_table=11
AL123456.3	EMBL	gene	2433631	2434536	.	-	.	ID=gene-Rv2172c;Name=Rv2172c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2172c
AL123456.3	EMBL	CDS	2433631	2434536	.	-	0	ID=cds-CCP44949.1;Parent=gene-Rv2172c;Dbxref=EnsemblGenomes-Gn:Rv2172c,EnsemblGenomes-Tr:CCP44949,UniProtKB/TrEMBL:O53506,NCBI_GP:CCP44949.1;Name=CCP44949.1;Note=Rv2172c%2C (MTV021.05c)%2C len: 301 aa. Conserved protein%2C equivalent to Mycobacterium leprae conserved hypothetical protein ML0901 (304 aa). FASTA scores: opt: 1656%2C E(): 7.7e-98%3B 81.271%25 identity in 299 aa overlap (1-299:1-299) >emb|CAA18681.1| (AL022602) >gi|13092971|emb|CAC31282.1| (AL583920). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2172c;product=Conserved protein;protein_id=CCP44949.1;transl_table=11
AL123456.3	EMBL	gene	2434847	2435905	.	+	.	ID=gene-Rv2173;Name=idsA2;gbkey=Gene;gene=idsA2;gene_biotype=protein_coding;locus_tag=Rv2173
AL123456.3	EMBL	CDS	2434847	2435905	.	+	0	ID=cds-CCP44950.1;Parent=gene-Rv2173;Dbxref=EnsemblGenomes-Gn:Rv2173,EnsemblGenomes-Tr:CCP44950,GOA:O53507,InterPro:IPR000092,InterPro:IPR008949,InterPro:IPR017446,UniProtKB/TrEMBL:O53507,NCBI_GP:CCP44950.1;Name=CCP44950.1;Note=Rv2173%2C (MTV021.06)%2C len: 352 aa. Probable idsA2%2Cgeranylgeranyl pyrophosphate synthase%2C similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Contains PS00723 and PS00444Polyprenyl synthetases signature 1 and 2. FASTA scores: sptr|Q54193|Q54193 geranylgeranyl pyrophosphate synthase (425 aa) opt: 744%2C E(): 0%3B 39.2%25 identity in 352 aa overlap.;gbkey=CDS;gene=idsA2;inference=protein motif:PROSITE:PS00723;locus_tag=Rv2173;product=Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase);protein_id=CCP44950.1;transl_table=11
AL123456.3	EMBL	gene	2435909	2437459	.	+	.	ID=gene-Rv2174;Name=mptA;gbkey=Gene;gene=mptA;gene_biotype=protein_coding;locus_tag=Rv2174
AL123456.3	EMBL	CDS	2435909	2437459	.	+	0	ID=cds-CCP44951.1;Parent=gene-Rv2174;Dbxref=EnsemblGenomes-Gn:Rv2174,EnsemblGenomes-Tr:CCP44951,GOA:O53508,InterPro:IPR017822,NCBI_GP:CCP44951.1;Name=CCP44951.1;Note=Rv2174%2C (MTV021.07)%2C len: 516 aa. MptA (mannopyranosyltransferase A) (See Mishra et al.%2C 2007). Possible conserved integral membrane protein%2C similar to some hypothetical mycobacterial proteins e.g. Mycobacterium leprae ML0899 probable integral-membrane protein (505 aa) and MLCL536_26 (593 aa). FASTA scores: ML0899 opt: 2715%3B 78.884%25 identity in 502 aa overlap and gp|Z99125|MLCL536_26 Mycobacterium leprae cosmid L536. (593 aa) opt: 552%2C E(): 7.1e-30%3B 31.6%25 identity in 513 aa overlap. Also similar to Rv1459c. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mptA;locus_tag=Rv2174;product=Alpha(1->6)mannosyltransferase. Possible conserved integral membrane protein.;protein_id=CCP44951.1;transl_table=11
AL123456.3	EMBL	gene	2437446	2437886	.	-	.	ID=gene-Rv2175c;Name=Rv2175c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2175c
AL123456.3	EMBL	CDS	2437446	2437886	.	-	0	ID=cds-CCP44952.1;Parent=gene-Rv2175c;Dbxref=EnsemblGenomes-Gn:Rv2175c,EnsemblGenomes-Tr:CCP44952,GOA:O53509,PDB:2KFS,NCBI_GP:CCP44952.1;Name=CCP44952.1;Note=Rv2175c%2C (MTV021.08c)%2C len: 146 aa. Conserved protein%2C possibly involved in regulation. Contains possible helix-turn-helix domain at aa 31-52 (Score 1042%2C +2.74 SD). Equivalent to Mycobacterium leprae ML0898 putative DNA-binding protein (134 aa). FASTA scores: opt: 747%3B 82.090%25 identity in 134 aa overlap (AL022602) >gi|13092969|emb|CAC31279.1| (AL583920). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2175c;product=Conserved regulatory protein;protein_id=CCP44952.1;transl_table=11
AL123456.3	EMBL	gene	2437823	2437866	.	-	.	ID=gene-mcr5;Name=mcr5;gbkey=Gene;gene=mcr5;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	2437823	2437866	.	-	.	ID=rna-mcr5;Parent=gene-mcr5;Note=mcr5%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C cloned from M. bovis BCG Pasteur%3B ends not mapped%2C ~~82 nt band detected by Northern blot.;gbkey=ncRNA;gene=mcr5;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	2437823	2437866	.	-	.	ID=exon-mcr5-1;Parent=rna-mcr5;Note=mcr5%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C cloned from M. bovis BCG Pasteur%3B ends not mapped%2C ~~82 nt band detected by Northern blot.;gbkey=ncRNA;gene=mcr5;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	2437941	2439140	.	+	.	ID=gene-Rv2176;Name=pknL;gbkey=Gene;gene=pknL;gene_biotype=protein_coding;locus_tag=Rv2176
AL123456.3	EMBL	CDS	2437941	2439140	.	+	0	ID=cds-CCP44953.1;Parent=gene-Rv2176;Dbxref=EnsemblGenomes-Gn:Rv2176,EnsemblGenomes-Tr:CCP44953,GOA:P9WI63,InterPro:IPR000719,InterPro:IPR008271,InterPro:IPR011009,NCBI_GP:CCP44953.1;Name=CCP44953.1;Note=Rv2176%2C (MTV021.09)%2C len: 399 aa. Probable pknL%2Ctransmembrane serine/threonine-protein kinase (see citation below)%2C similar to many e.g. MLCB1770_9 (622 aa). Lacks C-terminal domain and ends with putative transmembrane segment. Contains PS00108 Serine/Threonine protein kinases active-site signature. FASTA scores: Z70722|MLC B1770_9 Mycobacterium leprae cosmid B1770 (622 aa) opt: 732%2C E(): 5.9e-23%3B 44.4%25 identity in 266 aa overlap. Also similar to several Mycobacterium tuberculosis STPK proteins e.g. Rv0014c|PKNB%2C Rv0015c|PKNA%2C Rv1743|PKNE%2C Rv1266c|PKNH etc. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknL;inference=protein motif:PROSITE:PS00108;locus_tag=Rv2176;product=Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L);protein_id=CCP44953.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2439145	2439948	.	-	.	ID=id-AL123456.3:2439145..2439948;Note=IS1558-1%2C len: 804 nt. Insertion sequence IS1558%2Cnearly identical to complement of region 24105 24908 in EM_BA:MTCY428 Z81451 Mycobacterium tuberculosis cosmid Y428.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1558-1
AL123456.3	EMBL	gene	2439282	2439947	.	-	.	ID=gene-Rv2177c;Name=Rv2177c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2177c
AL123456.3	EMBL	CDS	2439282	2439947	.	-	0	ID=cds-CCP44954.1;Parent=gene-Rv2177c;Dbxref=EnsemblGenomes-Gn:Rv2177c,EnsemblGenomes-Tr:CCP44954,GOA:O53511,InterPro:IPR003346,UniProtKB/TrEMBL:O53511,NCBI_GP:CCP44954.1;Name=CCP44954.1;Note=Rv2177c%2C (MTV021.10c)%2C len: 221 aa. Possible IS1558 transposase (see citation below)%2C similar to several is element proteins and transposases but nearly identical to last 221 residues of MTCY428_23 (333 aa). FASTA scores: Z81451|MTCY428_23 Mycobacterium tuberculosis cosmid (333 aa) opt: 1491%2C E() : 0%3B 98.6%25 identity in 221 aa overlap.;gbkey=CDS;locus_tag=Rv2177c;product=Possible transposase;protein_id=CCP44954.1;transl_table=11
AL123456.3	EMBL	gene	2440332	2441720	.	-	.	ID=gene-Rv2178c;Name=aroG;gbkey=Gene;gene=aroG;gene_biotype=protein_coding;locus_tag=Rv2178c
AL123456.3	EMBL	CDS	2440332	2441720	.	-	0	ID=cds-CCP44955.1;Parent=gene-Rv2178c;Dbxref=EnsemblGenomes-Gn:Rv2178c,EnsemblGenomes-Tr:CCP44955,GOA:O53512,InterPro:IPR002480,PDB:2B7O,PDB:2W19,PDB:2W1A,PDB:2YPO,PDB:2YPP,PDB:2YPQ,PDB:3KGF,PDB:3NUD,PDB:3NUE,PDB:3NV8,PDB:3PFP,PDB:3RZI,NCBI_GP:CCP44955.1;Name=CCP44955.1;Note=Rv2178c%2C (MTV021.11c)%2C len: 462 aa. aroG%2C3-deoxy-D-arabino-heptulosonate 7-phosphate synthase similar to many%2C especially those from plants. FASTA scores: Y15113|M C3DDAH7P_1Morinda citrifolia mRNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (535 aa) opt: 1421%2C E(): 0%3B 48.3%25 identity in 443 aa overlap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aroG;locus_tag=Rv2178c;product=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase%2C phenylalanine-repressible);protein_id=CCP44955.1;transl_table=11
AL123456.3	EMBL	gene	2441811	2442317	.	-	.	ID=gene-Rv2179c;Name=Rv2179c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2179c
AL123456.3	EMBL	CDS	2441811	2442317	.	-	0	ID=cds-CCP44956.1;Parent=gene-Rv2179c;Dbxref=EnsemblGenomes-Gn:Rv2179c,EnsemblGenomes-Tr:CCP44956,GOA:P9WJ73,InterPro:IPR012337,PDB:4HEC,PDB:4HVJ,NCBI_GP:CCP44956.1;Name=CCP44956.1;Note=Rv2179c%2C (MTV021.12c)%2C len: 168 aa. Conserved hypothetical protein%2C equivalent to conserved hypothetical protein from Mycobacterium leprae ML0895 conserved hypothetical protein (171 aa). FASTA scores: opt: 977%2C E(): 1.4e-58%3B 82.530%25 identity in 166 aa overlap (AL022602). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2179c;product=Conserved hypothetical protein;protein_id=CCP44956.1;transl_table=11
AL123456.3	EMBL	gene	2442327	2443214	.	-	.	ID=gene-Rv2180c;Name=Rv2180c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2180c
AL123456.3	EMBL	CDS	2442327	2443214	.	-	0	ID=cds-CCP44957.1;Parent=gene-Rv2180c;Dbxref=EnsemblGenomes-Gn:Rv2180c,EnsemblGenomes-Tr:CCP44957,UniProtKB/TrEMBL:O53514,NCBI_GP:CCP44957.1;Name=CCP44957.1;Note=Rv2180c%2C (MTV021.13c)%2C len: 295 aa. Probable conserved integral membrane protein%2C similar to pir||T35292 probable integral membrane protein from Streptomyces coelicolor >gi|5578858|emb|CAB51260.1| (AL096872) (246 aa) (36%25 identity in 249 aa overlap).;gbkey=CDS;locus_tag=Rv2180c;product=Probable conserved integral membrane protein;protein_id=CCP44957.1;transl_table=11
AL123456.3	EMBL	gene	2443302	2444585	.	+	.	ID=gene-Rv2181;Name=Rv2181;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2181
AL123456.3	EMBL	CDS	2443302	2444585	.	+	0	ID=cds-CCP44958.1;Parent=gene-Rv2181;Dbxref=EnsemblGenomes-Gn:Rv2181,EnsemblGenomes-Tr:CCP44958,GOA:P9WMZ9,InterPro:IPR018584,NCBI_GP:CCP44958.1;Name=CCP44958.1;Note=Rv2181%2C (MTV021.14)%2C len: 427 aa. Alpha(1->2)mannosyltransferase (See Kaur et al.%2C 2006). Probable integral membrane protein%2C similar to others in Mycobacterium tuberculosis e.g. Rv1159 (MTCI65.26%2C 431 aa). Start uncertain. FASTA scores: Z95584|MTCI65_26 (431 aa) opt: 428%2C E(): 8e-22%3B 31.2%25 identity in 407 aa overlap. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2181;product=Alpha(1->2)mannosyltransferase;protein_id=CCP44958.1;transl_table=11
AL123456.3	EMBL	gene	2444586	2445329	.	-	.	ID=gene-Rv2182c;Name=Rv2182c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2182c
AL123456.3	EMBL	CDS	2444586	2445329	.	-	0	ID=cds-CCP44959.1;Parent=gene-Rv2182c;Dbxref=EnsemblGenomes-Gn:Rv2182c,EnsemblGenomes-Tr:CCP44959,GOA:O53516,InterPro:IPR002123,UniProtKB/TrEMBL:O53516,NCBI_GP:CCP44959.1;Name=CCP44959.1;Note=Rv2182c%2C (MTV021.15c)%2C len: 247 aa. Probable 1-acylglycerol-3-phosphate O-acyltransferase%2C similar to many e.g. in Streptomyces. Contains PS00017 ATP/GTP-binding site motif A (P-loop). FASTA scores: pir||T35503 1-acylglycerol-3-phosphate O-acyltransferase homolog SC6E10.16c - Streptomyces coelicolor >gi|5689932|emb|CAB51970.1| (AL109661) hypothetical protein [Streptomyces coelicolor A3(2)] Length %3D 262%2C Expect %3D 6e-61 (54%25 identity in 215 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2182c;product=1-acylglycerol-3-phosphate O-acyltransferase;protein_id=CCP44959.1;transl_table=11
AL123456.3	EMBL	gene	2445415	2445810	.	-	.	ID=gene-Rv2183c;Name=Rv2183c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2183c
AL123456.3	EMBL	CDS	2445415	2445810	.	-	0	ID=cds-CCP44960.1;Parent=gene-Rv2183c;Dbxref=EnsemblGenomes-Gn:Rv2183c,EnsemblGenomes-Tr:CCP44960,UniProtKB/TrEMBL:O53517,NCBI_GP:CCP44960.1;Name=CCP44960.1;Note=Rv2183c%2C (MTV021.16c)%2C len: 131 aa. Conserved protein%2C equivalent to Mycobacterium leprae hypothetical protein ML0891 (MLCB268.25c%2C 130 aa). FASTA scores: opt: 558%2C E(): 8.3e-28%3B 61.832%25 identity in 131 aa overlap >gi|13092963|emb|CAC31272.1| (AL583920) (AL022602). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2183c;product=Conserved protein;protein_id=CCP44960.1;transl_table=11
AL123456.3	EMBL	gene	2445807	2446946	.	-	.	ID=gene-Rv2184c;Name=Rv2184c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2184c
AL123456.3	EMBL	CDS	2445807	2446946	.	-	0	ID=cds-CCP44961.1;Parent=gene-Rv2184c;Dbxref=EnsemblGenomes-Gn:Rv2184c,EnsemblGenomes-Tr:CCP44961,GOA:O53518,InterPro:IPR016300,InterPro:IPR025723,InterPro:IPR027417,UniProtKB/TrEMBL:O53518,NCBI_GP:CCP44961.1;Name=CCP44961.1;Note=Rv2184c%2C (MTV021.17c)%2C len: 379 aa. Conserved hypothetical protein%2C equivalent to hypothetical protein ML0890 (415 aa) from Mycobacterium leprae and also shows some similarity to other hypothetical proteins. FASTA scores: ML0890 opt: 1949%3B 79.630%25 identity in 378 aa overlap >emb|CAA18692.1| (AL022602) >gi|13092962|emb|CAC31271.1| (AL583920) and sptr|Q55794|Q55794 hypothetical 44.6 kDa protein. (396 aa) opt: 251%2C E(): 3.3e-09%3B 25.5%25 identity in 384 aa overlap.;gbkey=CDS;locus_tag=Rv2184c;product=Conserved hypothetical protein;protein_id=CCP44961.1;transl_table=11
AL123456.3	EMBL	gene	2447066	2447500	.	-	.	ID=gene-Rv2185c;Name=TB16.3;gbkey=Gene;gene=TB16.3;gene_biotype=protein_coding;locus_tag=Rv2185c
AL123456.3	EMBL	CDS	2447066	2447500	.	-	0	ID=cds-CCP44962.1;Parent=gene-Rv2185c;Dbxref=EnsemblGenomes-Gn:Rv2185c,EnsemblGenomes-Tr:CCP44962,GOA:O53519,InterPro:IPR005031,InterPro:IPR023393,UniProtKB/TrEMBL:O53519,NCBI_GP:CCP44962.1;Name=CCP44962.1;Note=Rv2185c%2C (MTV021.18c)%2C len: 144 aa. TB16.3%2Cconserved protein%2C similar to other hypothetical actinomycete proteins and equivalent to Mycobacterium leprae ML0889 (144 aa). Some similarity to Mycobacterium tuberculosis Rv0854%2C Rv0856%2C Rv0857%2C Rv0164 and other Mycobacterium leprae proteins. FASTA scores : ML0889 opt: 811%3B 85.417%25 identity in 144 aa overlap (AL022602). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB16.3;locus_tag=Rv2185c;product=Conserved protein TB16.3;protein_id=CCP44962.1;transl_table=11
AL123456.3	EMBL	gene	2447605	2447994	.	-	.	ID=gene-Rv2186c;Name=Rv2186c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2186c
AL123456.3	EMBL	CDS	2447605	2447994	.	-	0	ID=cds-CCP44963.1;Parent=gene-Rv2186c;Dbxref=EnsemblGenomes-Gn:Rv2186c,EnsemblGenomes-Tr:CCP44963,UniProtKB/TrEMBL:O53520,NCBI_GP:CCP44963.1;Name=CCP44963.1;Note=Rv2186c%2C (MTV021.19c)%2C len: 129 aa. Conserved hypothetical protein%2C equivalent to hypothetical Mycobacterium leprae protein ML0888 (135 aa). FASTA scores: ML0888 opt: 704%2C E(): 2.9e-43%3B 80.000%25 identity in 130 aa overlap CAA18694.1| (AL022602). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2186c;product=Conserved hypothetical protein;protein_id=CCP44963.1;transl_table=11
AL123456.3	EMBL	gene	2448160	2449962	.	+	.	ID=gene-Rv2187;Name=fadD15;gbkey=Gene;gene=fadD15;gene_biotype=protein_coding;locus_tag=Rv2187
AL123456.3	EMBL	CDS	2448160	2449962	.	+	0	ID=cds-CCP44964.1;Parent=gene-Rv2187;Dbxref=EnsemblGenomes-Gn:Rv2187,EnsemblGenomes-Tr:CCP44964,GOA:O53521,InterPro:IPR000873,InterPro:IPR020845,NCBI_GP:CCP44964.1;Name=CCP44964.1;Note=Rv2187%2C (MTV021.20)%2C len: 600 aa. fadD15%2Clong-chain-fatty-acid-CoA ligase%2C similar to several e.g. P44446|LCFH_HAEIN putative long-chain-fatty-acid--CoA ligase from Haemophilus influenzae (607 aa)%2C FASTA scores: (607 aa) opt: 992%2C E(): 0%2C (31.5%25 identity in 578 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD15;inference=protein motif:PROSITE:PS00455;locus_tag=Rv2187;product=Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP44964.1;transl_table=11
AL123456.3	EMBL	gene	2449993	2451150	.	-	.	ID=gene-Rv2188c;Name=pimB;gbkey=Gene;gene=pimB;gene_biotype=protein_coding;locus_tag=Rv2188c
AL123456.3	EMBL	CDS	2449993	2451150	.	-	0	ID=cds-CCP44965.1;Parent=gene-Rv2188c;Dbxref=EnsemblGenomes-Gn:Rv2188c,EnsemblGenomes-Tr:CCP44965,GOA:P9WMZ3,InterPro:IPR001296,InterPro:IPR028098,NCBI_GP:CCP44965.1;Name=CCP44965.1;Note=Rv2188c%2C (MTV021.21c)%2C len: 385 aa. PimB (previously known as pimB')%2C mannosyltransferase. Equivalent to Mycobacterium leprae ML0886 putative glycosyl transferase (384 aa). FASTA scores: ML0886 (CAA18697.1| (AL022602) ) opt: 2113%2C E(): 1.8e-106%3B 81.462%25 identity in 383 aa overlap%3B sptr|P73369|P73369 hypothetical 46.2 kDa protein (404 aa) opt: 379%2C E(): 2.2e-18%3B 27.5%25 identity in 397 aa overlap. Start changed since first submission%2C now 14 aa shorter.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pimB;locus_tag=Rv2188c;product=Mannosyltransferase PimB;protein_id=CCP44965.1;transl_table=11
AL123456.3	EMBL	gene	2451247	2452020	.	-	.	ID=gene-Rv2189c;Name=Rv2189c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2189c
AL123456.3	EMBL	CDS	2451247	2452020	.	-	0	ID=cds-CCP44966.1;Parent=gene-Rv2189c;Dbxref=EnsemblGenomes-Gn:Rv2189c,EnsemblGenomes-Tr:CCP44966,UniProtKB/TrEMBL:O53523,NCBI_GP:CCP44966.1;Name=CCP44966.1;Note=Rv2189c%2C (MTV021.22c)%2C len: 257 aa. Conserved hypothetical protein%3B some similarity to hypothetical protein SC6G10.07c (385 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores: pir||T35516 hypothetical protein SC6G10.07c - Streptomyces coelicolor >gi|4539203|emb|CAB39861.1| (AL049497) Expect %3D 2e-08%3B 30%25 identity in 245 aa overlap.;gbkey=CDS;locus_tag=Rv2189c;product=Conserved hypothetical protein;protein_id=CCP44966.1;transl_table=11
AL123456.3	EMBL	gene	2452115	2453272	.	-	.	ID=gene-Rv2190c;Name=Rv2190c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2190c
AL123456.3	EMBL	CDS	2452115	2453272	.	-	0	ID=cds-CCP44967.1;Parent=gene-Rv2190c;Dbxref=EnsemblGenomes-Gn:Rv2190c,EnsemblGenomes-Tr:CCP44967,GOA:P9WHU3,InterPro:IPR000064,NCBI_GP:CCP44967.1;Name=CCP44967.1;Note=Rv2190c%2C (MTV021.23c%2C MTCY190.01c)%2C len: 385 aa. Conserved hypothetical protein%3B similar to other hypothetical mycobacterial proteins%2C including Rv1477%2CRv1478%2C Rv1566c%2C Rv0024%2C that are similar to protein p60 precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290%2C E(): 6.9e-05%3B 37.0%25 identity in 127 aa overlap and sp|Q01838|P60_LISSE protein P60 precursor (523 aa) opt: 268%2C E(): 0.00071%3B 38.5%25 identity in 104 aa overlap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2190c;product=Conserved hypothetical protein;protein_id=CCP44967.1;transl_table=11
AL123456.3	EMBL	gene	2453819	2455756	.	+	.	ID=gene-Rv2191;Name=Rv2191;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2191
AL123456.3	EMBL	CDS	2453819	2455756	.	+	0	ID=cds-CCP44968.1;Parent=gene-Rv2191;Dbxref=EnsemblGenomes-Gn:Rv2191,EnsemblGenomes-Tr:CCP44968,GOA:P9WLJ1,InterPro:IPR000305,InterPro:IPR006054,InterPro:IPR006055,InterPro:IPR012337,InterPro:IPR013520,NCBI_GP:CCP44968.1;Name=CCP44968.1;Note=Rv2191%2C (MTCY190.02)%2C len: 645 aa. Conserved hypothetical protein%2C similar to SW:DP3A_B ACSU P13267 DNA polymerase III%2C alpha chain (31.3%25 identity in 249 aa overlap) and SW:UVRC_ECOLI P07028 excinuclease ABC subunit C (25.7%25 identity in 230 aa overlap). Also similar to M. tuberculosis Rv3711c (dnaQ DNA polymerase III e chain) and Rv1420 (uvrC excinuclease ABC subunit C);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2191;product=Conserved hypothetical protein;protein_id=CCP44968.1;transl_table=11
AL123456.3	EMBL	gene	2455631	2456743	.	-	.	ID=gene-Rv2192c;Name=trpD;gbkey=Gene;gene=trpD;gene_biotype=protein_coding;locus_tag=Rv2192c
AL123456.3	EMBL	CDS	2455631	2456743	.	-	0	ID=cds-CCP44969.1;Parent=gene-Rv2192c;Dbxref=EnsemblGenomes-Gn:Rv2192c,EnsemblGenomes-Tr:CCP44969,GOA:P9WFX5,InterPro:IPR000312,InterPro:IPR005940,InterPro:IPR017459,PDB:1ZVW,PDB:2BPQ,PDB:3QQS,PDB:3QR9,PDB:3QS8,PDB:3QSA,PDB:3R6C,PDB:3R88,PDB:3TWP,PDB:3UU1,PDB:4GIU,PDB:4GKM,PDB:4IJ1,PDB:4N5V,PDB:4N8Q,PDB:4N93,PDB:4OWM,PDB:4OWN,PDB:4OWO,PDB:4OWQ,PDB:4OWS,PDB:4OWU,PDB:4OWV,NCBI_GP:CCP44969.1;Name=CCP44969.1;Note=Rv2192c%2C (MTCY190.03c)%2C len: 370 aa. Probable trpD%2Canthranilate phosphoribosyltransferase (see citation below)%2C similar to e.g. TRPD_LACCA|P17170%2C (43.2%25 identity in 308 aa overlap). Initiation codon uncertain%2C gtg at 4086 in MTCY190 favoured by homology but this has no clear ribosome binding site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trpD;locus_tag=Rv2192c;product=Probable anthranilate phosphoribosyltransferase TrpD;protein_id=CCP44969.1;transl_table=11
AL123456.3	EMBL	gene	2456901	2457512	.	+	.	ID=gene-Rv2193;Name=ctaE;gbkey=Gene;gene=ctaE;gene_biotype=protein_coding;locus_tag=Rv2193
AL123456.3	EMBL	CDS	2456901	2457512	.	+	0	ID=cds-CCP44970.1;Parent=gene-Rv2193;Dbxref=EnsemblGenomes-Gn:Rv2193,EnsemblGenomes-Tr:CCP44970,GOA:P9WP67,InterPro:IPR000298,InterPro:IPR013833,InterPro:IPR024791,NCBI_GP:CCP44970.1;Name=CCP44970.1;Note=Rv2193%2C (MTCY190.04)%2C len: 203 aa. Probable ctaE%2Ccytochrome c oxidase polypeptide III (cox3)%2C with strong similarity to others e.g. COX3_SYNY3|Q06475 (29.8%25 identity in 225 aa overlap).;gbkey=CDS;gene=ctaE;locus_tag=Rv2193;product=Probable cytochrome C oxidase (subunit III) CtaE;protein_id=CCP44970.1;transl_table=11
AL123456.3	EMBL	gene	2457553	2458395	.	+	.	ID=gene-Rv2194;Name=qcrC;gbkey=Gene;gene=qcrC;gene_biotype=protein_coding;locus_tag=Rv2194
AL123456.3	EMBL	CDS	2457553	2458395	.	+	0	ID=cds-CCP44971.1;Parent=gene-Rv2194;Dbxref=EnsemblGenomes-Gn:Rv2194,EnsemblGenomes-Tr:CCP44971,GOA:P9WP35,InterPro:IPR003088,InterPro:IPR009056,InterPro:IPR009152,NCBI_GP:CCP44971.1;Name=CCP44971.1;Note=Rv2194%2C (MTCY190.05)%2C len: 280 aa. Probable qcrC%2CUbiquinol-cytochrome C reductase cytochrome C subunit (cyoA)%2C shows similarity to cytochrome c family%3B contains 2 X PS00190 Cytochrome c family heme-binding site signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=qcrC;locus_tag=Rv2194;product=Probable ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit);protein_id=CCP44971.1;transl_table=11
AL123456.3	EMBL	gene	2458392	2459681	.	+	.	ID=gene-Rv2195;Name=qcrA;gbkey=Gene;gene=qcrA;gene_biotype=protein_coding;locus_tag=Rv2195
AL123456.3	EMBL	CDS	2458392	2459681	.	+	0	ID=cds-CCP44972.1;Parent=gene-Rv2195;Dbxref=EnsemblGenomes-Gn:Rv2195,EnsemblGenomes-Tr:CCP44972,GOA:P9WH23,InterPro:IPR017941,NCBI_GP:CCP44972.1;Name=CCP44972.1;Note=Rv2195%2C (MTCY190.06)%2C len: 429 aa. Probable qcrA%2CUbiquinol-cytochrome C reductase iron-sulfur subunit (cyoB)%2C shows some similarity to cytochrome B6-F complex iron-sulphur subunits (Rieske iron-sulfur protein)%3B contains PS00200 Rieske iron-sulfur protein signature 2;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=qcrA;locus_tag=Rv2195;product=Probable rieske iron-sulfur protein QcrA;protein_id=CCP44972.1;transl_table=11
AL123456.3	EMBL	repeat_region	2458392	2458449	.	+	.	ID=id-Rv2195;Note=58 bp Mycobacterial Interspersed Repetitive Unit%2CClass II I. Overlaps Rv2195 suggesting alternative GTG start at 2458 468 may be used;gbkey=repeat_region;gene=qcrA;locus_tag=Rv2195
AL123456.3	EMBL	gene	2459678	2461327	.	+	.	ID=gene-Rv2196;Name=qcrB;gbkey=Gene;gene=qcrB;gene_biotype=protein_coding;locus_tag=Rv2196
AL123456.3	EMBL	CDS	2459678	2461327	.	+	0	ID=cds-CCP44973.1;Parent=gene-Rv2196;Dbxref=EnsemblGenomes-Gn:Rv2196,EnsemblGenomes-Tr:CCP44973,GOA:P9WP37,InterPro:IPR005797,InterPro:IPR016174,InterPro:IPR027387,NCBI_GP:CCP44973.1;Name=CCP44973.1;Note=Rv2196%2C (MTCY190.07)%2C len: 549 aa. Probable qcrB%2CUbiquinol-cytochrome C reductase cytochrome B subunit (cytB)%2C integral membrane protein%2C low similarity in amino-terminal half to cytochrome b subunits%2C highly similar at C-terminus to SW:12KD_MYCLE P15878 12 KD protein PIR:S08427 (86.9%25 identity in 153 aa overlap). FASTA scores: sp|Q45658|QCRB_BACST menaquinol-cytochrome C reductase (224 aa) opt: 341%2C E(): 6.8e-15%3B 28.0%25 identity in 207 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=qcrB;locus_tag=Rv2196;product=Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit);protein_id=CCP44973.1;transl_table=11
AL123456.3	EMBL	gene	2461504	2462148	.	-	.	ID=gene-Rv2197c;Name=Rv2197c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2197c
AL123456.3	EMBL	CDS	2461504	2462148	.	-	0	ID=cds-CCP44974.1;Parent=gene-Rv2197c;Dbxref=EnsemblGenomes-Gn:Rv2197c,EnsemblGenomes-Tr:CCP44974,GOA:P9WLI9,InterPro:IPR024381,NCBI_GP:CCP44974.1;Name=CCP44974.1;Note=Rv2197c%2C (MTCY190.08c)%2C len: 214 aa. Probable conserved transmembrane protein%2C equivalent to ML0878 conserved hypothetical protein (212 aa) of Mycobacterium leprae. FASTA scores: opt: 858%3B 62.559%25 identity in 211 aa overlap CAC31259.1|(AL583920). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2197c;product=Probable conserved transmembrane protein;protein_id=CCP44974.1;transl_table=11
AL123456.3	EMBL	gene	2462148	2463047	.	-	.	ID=gene-Rv2198c;Name=mmpS3;gbkey=Gene;gene=mmpS3;gene_biotype=protein_coding;locus_tag=Rv2198c
AL123456.3	EMBL	CDS	2462148	2463047	.	-	0	ID=cds-CCP44975.1;Parent=gene-Rv2198c;Dbxref=EnsemblGenomes-Gn:Rv2198c,EnsemblGenomes-Tr:CCP44975,GOA:P9WJT1,InterPro:IPR008693,NCBI_GP:CCP44975.1;Name=CCP44975.1;Note=Rv2198c%2C (MTCY190.09c)%2C len: 299 aa. Probable mmpS3%2Cconserved membrane protein (see citation below)%2C equivalent to ML0877|mmpS3 putative membrane protein from Mycobacterium leprae (293 aa)%2C FASTA scores: opt: 1089%2CE(): 1.2e-43%2C (69.80%25 identity in 308 aa overlap). Also similar to other proteins e.g. Rv3209 from Mycobacterium tuberculosis. Contains PS00499 C2 domain signature%2C a hydrophobic region%2C and a repetitive proline and threonine rich region. Belongs to the MmpS family. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpS3;locus_tag=Rv2198c;product=Probable conserved membrane protein MmpS3;protein_id=CCP44975.1;transl_table=11
AL123456.3	EMBL	gene	2463233	2463652	.	-	.	ID=gene-Rv2199c;Name=Rv2199c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2199c
AL123456.3	EMBL	CDS	2463233	2463652	.	-	0	ID=cds-CCP44976.1;Parent=gene-Rv2199c;Dbxref=EnsemblGenomes-Gn:Rv2199c,EnsemblGenomes-Tr:CCP44976,GOA:P9WP45,InterPro:IPR021050,NCBI_GP:CCP44976.1;Name=CCP44976.1;Note=Rv2199c%2C (MTCY190.10c)%2C len: 139 aa. Possible conserved integral membrane protein%2C similar to hypothetical membrane proteins in Actinomycetes and equivalent to Mycobacterium leprae%2C ML0876%2C putative membrane protein (139 aa) FASTA scores: opt: 866%2C E(): 1.1e-43%3B 91.367%25 identity in 139 aa overlap CAC31257.1| (AL583920);gbkey=CDS;locus_tag=Rv2199c;product=Possible conserved integral membrane protein;protein_id=CCP44976.1;transl_table=11
AL123456.3	EMBL	gene	2463660	2464751	.	-	.	ID=gene-Rv2200c;Name=ctaC;gbkey=Gene;gene=ctaC;gene_biotype=protein_coding;locus_tag=Rv2200c
AL123456.3	EMBL	CDS	2463660	2464751	.	-	0	ID=cds-CCP44977.1;Parent=gene-Rv2200c;Dbxref=EnsemblGenomes-Gn:Rv2200c,EnsemblGenomes-Tr:CCP44977,GOA:P9WP69,InterPro:IPR001505,InterPro:IPR002429,InterPro:IPR008972,InterPro:IPR011759,NCBI_GP:CCP44977.1;Name=CCP44977.1;Note=Rv2200c%2C (MTCY190.11c)%2C len: 363 aa. Probable ctaC%2Ctransmembrane cytochrome C oxidase (subunit II)%2C COX2%2Csimilar e.g. to JT0964 cytochrome-c oxidase chain II (23.0%25 identity in 317 aa overlap)%3B etc. Contains PS00078 Cytochrome c oxidase subunit II%2C copper a binding region signature. Belongs to the cytochrome C oxidase subunit 2 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctaC;locus_tag=Rv2200c;product=Probable transmembrane cytochrome C oxidase (subunit II) CtaC;protein_id=CCP44977.1;transl_table=11
AL123456.3	EMBL	gene	2464997	2466955	.	+	.	ID=gene-Rv2201;Name=asnB;gbkey=Gene;gene=asnB;gene_biotype=protein_coding;locus_tag=Rv2201
AL123456.3	EMBL	CDS	2464997	2466955	.	+	0	ID=cds-CCP44978.1;Parent=gene-Rv2201;Dbxref=EnsemblGenomes-Gn:Rv2201,EnsemblGenomes-Tr:CCP44978,GOA:P9WN33,InterPro:IPR000583,InterPro:IPR001962,InterPro:IPR006426,InterPro:IPR014729,InterPro:IPR017932,InterPro:IPR029055,NCBI_GP:CCP44978.1;Name=CCP44978.1;Note=Rv2201%2C (MTCY190.12)%2C len: 652 aa. Probable asnB%2Casparagine synthetase%2C similar to e.g. SW:ASNH_BACSU P42113 putative asparagine synthetase (26.0%25 identity in 438 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=asnB;locus_tag=Rv2201;product=Probable asparagine synthetase AsnB;protein_id=CCP44978.1;transl_table=11
AL123456.3	EMBL	gene	2467053	2468027	.	-	.	ID=gene-Rv2202c;Name=adoK;gbkey=Gene;gene=adoK;gene_biotype=protein_coding;locus_tag=Rv2202c
AL123456.3	EMBL	CDS	2467053	2468027	.	-	0	ID=cds-CCP44979.1;Parent=gene-Rv2202c;Dbxref=EnsemblGenomes-Gn:Rv2202c,EnsemblGenomes-Tr:CCP44979,GOA:P9WID5,InterPro:IPR002173,InterPro:IPR011611,InterPro:IPR029056,PDB:2PKF,PDB:2PKK,PDB:2PKM,PDB:2PKN,NCBI_GP:CCP44979.1;Name=CCP44979.1;Note=Rv2202c%2C (MTCY190.13c)%2C len: 324 aa. AdoK%2C Adenosine kinase activity proven biochemically (See Long et al. 2003). Similar to several others but shows greater sequence homology with ribokinase and fructokinase than it does with other AKs e.g. AE000915_1 Methanobacterium thermoautotrop (309 aa) FASTA score: opt: 370%2C E(): 3.3e-18%3B 31.2%25 identity in 276 aa overlap. Low similarity to carbohydrate kinases%2C e.g. SW:RBSK_BACSU P36945 ribokinase (23.9%25 identity in 272 aa overlap)%3B contains PS00583 pfkB family of carbohydrate kinases signature 1. Previously known as cbhK;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adoK;locus_tag=Rv2202c;product=Adenosine kinase;protein_id=CCP44979.1;transl_table=11
AL123456.3	EMBL	gene	2468231	2468923	.	+	.	ID=gene-Rv2203;Name=Rv2203;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2203
AL123456.3	EMBL	CDS	2468231	2468923	.	+	0	ID=cds-CCP44980.1;Parent=gene-Rv2203;Dbxref=EnsemblGenomes-Gn:Rv2203,EnsemblGenomes-Tr:CCP44980,GOA:P9WLI7,NCBI_GP:CCP44980.1;Name=CCP44980.1;Note=Rv2203%2C (MTCY190.14)%2C len: 230 aa. Possible conserved membrane protein%3B has single hydrophobic stretch from aa 75 to 97 and is equivalent to Mycobacterium leprae ML0872 putative membrane protein (171 aa). FASTA scores: opt: 821%2C E(): 3.4e-42%3B 72.353%25 identity in 170 aa overlap - CAC31253.1| (AL583920). 2468411. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2203;product=Possible conserved membrane protein;protein_id=CCP44980.1;transl_table=11
AL123456.3	EMBL	gene	2468931	2469287	.	-	.	ID=gene-Rv2204c;Name=Rv2204c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2204c
AL123456.3	EMBL	CDS	2468931	2469287	.	-	0	ID=cds-CCP44981.1;Parent=gene-Rv2204c;Dbxref=EnsemblGenomes-Gn:Rv2204c,EnsemblGenomes-Tr:CCP44981,GOA:P9WMN5,InterPro:IPR000361,InterPro:IPR016092,InterPro:IPR017870,NCBI_GP:CCP44981.1;Name=CCP44981.1;Note=Rv2204c%2C (MTCY190.15c)%2C len: 118 aa. Conserved protein. Similar to conserved hypothetical proteins in Actinomycetes and equivalent to Mycobacterium leprae ML0871|ML0871 conserved hypothetical protein (118 aa) and to sp|P45344|YADR_HAEIN hypothetical protein HI1723 (114 aa). FASTA score: ML0871 opt: 720%2C E(): 8.4e-45%3B 92.373%25 identity in 118 aa overlapCAC31252.1| (AL583920)%3B and P45344 opt: 346%2C E(): 1.8e-18%3B 45.6%25 identity in 103 aa overlap. Contains PS01152 Hypothetical hesB/y yadR/yfhF family signature;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2204c;product=Conserved protein;protein_id=CCP44981.1;transl_table=11
AL123456.3	EMBL	gene	2469387	2470463	.	-	.	ID=gene-Rv2205c;Name=Rv2205c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2205c
AL123456.3	EMBL	CDS	2469387	2470463	.	-	0	ID=cds-CCP44982.1;Parent=gene-Rv2205c;Dbxref=EnsemblGenomes-Gn:Rv2205c,EnsemblGenomes-Tr:CCP44982,GOA:P9WMT7,InterPro:IPR004381,InterPro:IPR018193,NCBI_GP:CCP44982.1;Name=CCP44982.1;Note=Rv2205c%2C (MTCY190.16c)%2C len: 358 aa. Conserved hypothetical protein. Very similar to YHAD_ECOLI|P23524 hypothetical protein (YHAD (E.coli) / YXAA (S14A) (B.subtilis) family) (41.6%25 identity in 154 aa overlap)%2Cand to other members of the glycerate kinase family. Start changed since first submission%3B protein now 122 aa shorter%2Cowing to extension of Rv2206. Nucleotide position 2470149 in the genome sequence has been corrected%2C T:C resulting in E105E.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2205c;product=Conserved hypothetical protein;protein_id=CCP44982.1;transl_table=11
AL123456.3	EMBL	gene	2470622	2471332	.	+	.	ID=gene-Rv2206;Name=Rv2206;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2206
AL123456.3	EMBL	CDS	2470622	2471332	.	+	0	ID=cds-CCP44983.1;Parent=gene-Rv2206;Dbxref=EnsemblGenomes-Gn:Rv2206,EnsemblGenomes-Tr:CCP44983,GOA:P9WLI5,InterPro:IPR021403,NCBI_GP:CCP44983.1;Name=CCP44983.1;Note=Rv2206%2C (MTCY190.17)%2C len: 236 aa. Probable conserved transmembrane protein. Equivalent to hypothetical protein ML0869 (247 aa) of Mycobacterium leprae gZ98741|MLCB22_2 (247 aa)%2C FASTA scores: opt: 1052%2C (67.5%25 identity in 237 aa overlap). Two hydrophobic stretches in C-terminal part. Start changed since original submission (+112 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2206;product=Probable conserved transmembrane protein;protein_id=CCP44983.1;transl_table=11
AL123456.3	EMBL	gene	2471411	2472496	.	+	.	ID=gene-Rv2207;Name=cobT;gbkey=Gene;gene=cobT;gene_biotype=protein_coding;locus_tag=Rv2207
AL123456.3	EMBL	CDS	2471411	2472496	.	+	0	ID=cds-CCP44984.1;Parent=gene-Rv2207;Dbxref=EnsemblGenomes-Gn:Rv2207,EnsemblGenomes-Tr:CCP44984,GOA:P9WP85,InterPro:IPR003200,InterPro:IPR017846,InterPro:IPR023195,NCBI_GP:CCP44984.1;Name=CCP44984.1;Note=Rv2207%2C (MTCY190.18)%2C len: 361 aa. Probable cobT%2Cphosphoribosyltransferase%2C similar to many e.g. SW:COBT_ECOLI P36562 nicotinate-nucleotide--dimethylbenzimidazol phosphoribosyltransferase (34.6%25 identity in 341 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobT;locus_tag=Rv2207;product=Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT;protein_id=CCP44984.1;transl_table=11
AL123456.3	EMBL	gene	2472493	2473242	.	+	.	ID=gene-Rv2208;Name=cobS;gbkey=Gene;gene=cobS;gene_biotype=protein_coding;locus_tag=Rv2208
AL123456.3	EMBL	CDS	2472493	2473242	.	+	0	ID=cds-CCP44985.1;Parent=gene-Rv2208;Dbxref=EnsemblGenomes-Gn:Rv2208,EnsemblGenomes-Tr:CCP44985,GOA:P9WP91,InterPro:IPR003805,NCBI_GP:CCP44985.1;Name=CCP44985.1;Note=Rv2208%2C (MTCY190.19)%2C len: 249 aa. Probable cobS%2Ccobalamin 5'-phosphate synthase%3B similarity to SW:COBS_ECOLI P36561 cobalamin (5'-phosphate) synthase (28.0%25 identity in 243 aa overlap);gbkey=CDS;gene=cobS;locus_tag=Rv2208;product=Probable cobalamin 5'-phosphate synthase CobS;protein_id=CCP44985.1;transl_table=11
AL123456.3	EMBL	gene	2473400	2474938	.	+	.	ID=gene-Rv2209;Name=Rv2209;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2209
AL123456.3	EMBL	CDS	2473400	2474938	.	+	0	ID=cds-CCP44986.1;Parent=gene-Rv2209;Dbxref=EnsemblGenomes-Gn:Rv2209,EnsemblGenomes-Tr:CCP44986,GOA:P9WLI3,InterPro:IPR016196,NCBI_GP:CCP44986.1;Name=CCP44986.1;Note=Rv2209%2C (MTCY190.20)%2C len: 512 aa. Probable conserved integral membrane protein%2C similar to but longer than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis (436 aa). FASTA score: opt: 712%2C E(): 2.8e-32%3B 33.4%25 identity in 422 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2209;product=Probable conserved integral membrane protein;protein_id=CCP44986.1;transl_table=11
AL123456.3	EMBL	gene	2474864	2475970	.	-	.	ID=gene-Rv2210c;Name=ilvE;gbkey=Gene;gene=ilvE;gene_biotype=protein_coding;locus_tag=Rv2210c
AL123456.3	EMBL	CDS	2474864	2475970	.	-	0	ID=cds-CCP44987.1;Parent=gene-Rv2210c;Dbxref=EnsemblGenomes-Gn:Rv2210c,EnsemblGenomes-Tr:CCP44987,GOA:P9WQ75,InterPro:IPR001544,InterPro:IPR005786,InterPro:IPR018300,PDB:3HT5,NCBI_GP:CCP44987.1;Name=CCP44987.1;Note=Rv2210c%2C (MTCY190.21c)%2C len: 368 aa. ilvE%2CBranched-chain-amino-acid transaminase%2C highly similar to many e.g. YWAA_BACSU|P39576 from Bacillus subtilis (48.4%25 identity in 339 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvE;locus_tag=Rv2210c;product=Branched-chain amino acid transaminase IlvE;protein_id=CCP44987.1;transl_table=11
AL123456.3	EMBL	gene	2476042	2477181	.	-	.	ID=gene-Rv2211c;Name=gcvT;gbkey=Gene;gene=gcvT;gene_biotype=protein_coding;locus_tag=Rv2211c
AL123456.3	EMBL	CDS	2476042	2477181	.	-	0	ID=cds-CCP44988.1;Parent=gene-Rv2211c;Dbxref=EnsemblGenomes-Gn:Rv2211c,EnsemblGenomes-Tr:CCP44988,GOA:P9WN51,InterPro:IPR006222,InterPro:IPR006223,InterPro:IPR013977,InterPro:IPR022903,InterPro:IPR027266,InterPro:IPR028896,InterPro:IPR029043,NCBI_GP:CCP44988.1;Name=CCP44988.1;Note=Rv2211c%2C (MTCY190.22)%2C len: 379 aa. Probable gcvT%2Caminomethyltransferase%2C similar to many e.g. GCST_ECOLI|P27248 for Escherichia coli (38.2%25 identity in 364 aa overlap)%3B etc. Belongs to the GcvT family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gcvT;locus_tag=Rv2211c;product=Probable aminomethyltransferase GcvT (glycine cleavage system T protein);protein_id=CCP44988.1;transl_table=11
AL123456.3	EMBL	gene	2477190	2478326	.	+	.	ID=gene-Rv2212;Name=Rv2212;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2212
AL123456.3	EMBL	CDS	2477190	2478326	.	+	0	ID=cds-CCP44989.1;Parent=gene-Rv2212;Dbxref=EnsemblGenomes-Gn:Rv2212,EnsemblGenomes-Tr:CCP44989,GOA:P9WMU7,InterPro:IPR001054,InterPro:IPR029787,NCBI_GP:CCP44989.1;Name=CCP44989.1;Note=Rv2212%2C (MTCY190.23)%2C len: 378 aa. Adenylyl cyclase (See Abdel Motaal et al.%2C 2006). Some similarity to e.g. SW:CYAA_STRCO P40135 adenylate cyclase (29.2%25 identity in 291 aa overlap)%3B ttg at 24614 in MTCY190 has a better rbs. Contains possible helix-turn-helix motif at aa 64-85%2C(+2.72 SD). Also similar to Rv1264 and Rv1647;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2212;product=Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase);protein_id=CCP44989.1;transl_table=11
AL123456.3	EMBL	gene	2478338	2479885	.	+	.	ID=gene-Rv2213;Name=pepB;gbkey=Gene;gene=pepB;gene_biotype=protein_coding;locus_tag=Rv2213
AL123456.3	EMBL	CDS	2478338	2479885	.	+	0	ID=cds-CCP44990.1;Parent=gene-Rv2213;Dbxref=EnsemblGenomes-Gn:Rv2213,EnsemblGenomes-Tr:CCP44990,GOA:P9WHT3,InterPro:IPR000819,InterPro:IPR008283,InterPro:IPR011356,InterPro:IPR023042,NCBI_GP:CCP44990.1;Name=CCP44990.1;Note=Rv2213%2C (MTCY190.24)%2C len: 515 aa. Probable pepB%2Cleucine aminopeptidase%2C similar to many e.g. SW:AMPA_ECOLI P11648 aminopeptidase a/I%2C (41.4%25 identity in 309 aa overlap). Equivalent to Z98741|MLCB22_6 Mycobacterium leprae cosmid B22%3B Am (524 aa)%2C FASTA scores: opt: 2793%2CE(): 0%3B 83.1%25 identity in 522 aa overlap. Contains PS00631 Cytosol aminopeptidase signature%2C ntdaegrl. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepB;locus_tag=Rv2213;product=Probable aminopeptidase PepB;protein_id=CCP44990.1;transl_table=11
AL123456.3	EMBL	gene	2479923	2481701	.	-	.	ID=gene-Rv2214c;Name=ephD;gbkey=Gene;gene=ephD;gene_biotype=protein_coding;locus_tag=Rv2214c
AL123456.3	EMBL	CDS	2479923	2481701	.	-	0	ID=cds-CCP44991.1;Parent=gene-Rv2214c;Dbxref=EnsemblGenomes-Gn:Rv2214c,EnsemblGenomes-Tr:CCP44991,GOA:P9WGS3,InterPro:IPR000073,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,InterPro:IPR029058,NCBI_GP:CCP44991.1;Name=CCP44991.1;Note=Rv2214c%2C (MTCY190.25c)%2C len: 592 aa. Possible ephD%2Cshort-chain dehydrogenase (see citation below)%2C equivalent to Z98741|MLCB22_8 Mycobacterium leprae cosmid B22%3B (596 aa)%2C FASTA score: opt: 3262%2C E(): 0%3B 80.4%25 identity in 596 aa overlap. C-terminus similar to short-chain alcohol dehydrogenase family%2C similar to SW:LIGD_PSEPA Q01198 c alpha-dehydrogenase (30.7%25 identity in 241 aa overlap)%3B contains PS00061 Short-chain alcohol dehydrogenase family signature%2C PS00697 ATP-dependent DNA ligase AMP-binding site. N-terminus corresponds to several epoxide hydrolases of plants and Mycobacterium tuberculosis e.g. MTCY9F925;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ephD;locus_tag=Rv2214c;product=Possible short-chain dehydrogenase EphD;protein_id=CCP44991.1;transl_table=11
AL123456.3	EMBL	gene	2481965	2483626	.	+	.	ID=gene-Rv2215;Name=dlaT;gbkey=Gene;gene=dlaT;gene_biotype=protein_coding;locus_tag=Rv2215
AL123456.3	EMBL	CDS	2481965	2483626	.	+	0	ID=cds-CCP44992.1;Parent=gene-Rv2215;Dbxref=EnsemblGenomes-Gn:Rv2215,EnsemblGenomes-Tr:CCP44992,GOA:P9WIS7,InterPro:IPR000089,InterPro:IPR001078,InterPro:IPR003016,InterPro:IPR004167,InterPro:IPR011053,InterPro:IPR014276,InterPro:IPR023213,NCBI_GP:CCP44992.1;Name=CCP44992.1;Note=Rv2215%2C (MTCY190.26)%2C len: 553 aa. DlaT%2Cdihydrolipoamide acyltransferase%2C E2 component of pyruvate dehydrogenase%2C proven biochemically (see Tian et al. 2005)%2Csimilar to e.g. SW:O PD2_ACHLA P35489 dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex (35.3%25 identity in 552 aa overlap)%3B contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. Rhodanine compounds inhibit DlaT|Rv2215 and can kill non-replicating mycobacteria in mouse bone marrow-derived macrophages (See Bryk et al.%2C2008). LpdC|Rv0462 co-immunoprecipitates with DlaT|Rv2215 (in lpdC|Rv0462 mutant) and with BkdC|Rv2495c (in dlaT|Rv2215 mutant) (See Venugopal et al.%2C 2011).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dlaT;locus_tag=Rv2215;product=DlaT%2C dihydrolipoamide acyltransferase%2C E2 component of pyruvate dehydrogenase;protein_id=CCP44992.1;transl_table=11
AL123456.3	EMBL	gene	2483626	2484531	.	+	.	ID=gene-Rv2216;Name=Rv2216;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2216
AL123456.3	EMBL	CDS	2483626	2484531	.	+	0	ID=cds-CCP44993.1;Parent=gene-Rv2216;Dbxref=EnsemblGenomes-Gn:Rv2216,EnsemblGenomes-Tr:CCP44993,GOA:P9WGP7,InterPro:IPR001509,InterPro:IPR010099,InterPro:IPR013549,InterPro:IPR016040,NCBI_GP:CCP44993.1;Name=CCP44993.1;Note=Rv2216%2C (MTCY190.27)%2C len: 301 aa. Conserved protein%2C equivalent to Mycobacterium leprae ML0860 (307 aa)%2C Z98741|MLCB22_10 Mycobacterium leprae cosmid B22%3B H (307 aa). FASTA score: opt: 1656%2C E(): 0%3B 84.2%25 identity in 297 aa overlap. Also gp|AE000319|ECAE000319_8 Escherichia coli strain K12 MG1655 (297 aa) opt: 640%2C E(): 0%3B 39.5%25 identity in 294 aa overlap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2216;product=Conserved protein;protein_id=CCP44993.1;transl_table=11
AL123456.3	EMBL	gene	2484584	2485276	.	+	.	ID=gene-Rv2217;Name=lipB;gbkey=Gene;gene=lipB;gene_biotype=protein_coding;locus_tag=Rv2217
AL123456.3	EMBL	CDS	2484584	2485276	.	+	0	ID=cds-CCP44994.1;Parent=gene-Rv2217;Dbxref=EnsemblGenomes-Gn:Rv2217,EnsemblGenomes-Tr:CCP44994,GOA:P9WK83,InterPro:IPR000544,InterPro:IPR004143,InterPro:IPR020605,PDB:1W66,NCBI_GP:CCP44994.1;Name=CCP44994.1;Note=Rv2217%2C (MTCY190.28)%2C len: 230 aa. Probable lipB%2Csimilar to SW:LIPB_ECOLI P30976 liopate biosynthesis protein B (33.8%25 identity in 160 aa overlap). Equivalent to gp|Z98741| MLCB22_11 Mycobacterium leprae (235 aa). FASTA score: opt: 1124%2C E(): 0%3B 78.4%25 identity in 218 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipB;locus_tag=Rv2217;product=Probable lipoate biosynthesis protein B LipB;protein_id=CCP44994.1;transl_table=11
AL123456.3	EMBL	gene	2485273	2486208	.	+	.	ID=gene-Rv2218;Name=lipA;gbkey=Gene;gene=lipA;gene_biotype=protein_coding;locus_tag=Rv2218
AL123456.3	EMBL	CDS	2485273	2486208	.	+	0	ID=cds-CCP44995.1;Parent=gene-Rv2218;Dbxref=EnsemblGenomes-Gn:Rv2218,EnsemblGenomes-Tr:CCP44995,GOA:P9WK91,InterPro:IPR003698,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR013785,NCBI_GP:CCP44995.1;Name=CCP44995.1;Note=Rv2218%2C (MTCY190.29)%2C len: 311 aa. Probable lipA%2Clipoic acid synthetase%2C similar to e.g. SW:LIPA_HAEIN P44463 (42.6%25 identity in 291 aa overlap). Equivalent to Z98741|MLCB2 2_12 Mycobacterium leprae cosmid B22%3B (314 aa). FASTA score : opt: 1836%2C E(): 0%3B 86.8%25 identity in 310 aa overlap;gbkey=CDS;gene=lipA;locus_tag=Rv2218;product=Probable lipoate biosynthesis protein A LipA;protein_id=CCP44995.1;transl_table=11
AL123456.3	EMBL	gene	2486235	2486987	.	+	.	ID=gene-Rv2219;Name=Rv2219;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2219
AL123456.3	EMBL	CDS	2486235	2486987	.	+	0	ID=cds-CCP44996.1;Parent=gene-Rv2219;Dbxref=EnsemblGenomes-Gn:Rv2219,EnsemblGenomes-Tr:CCP44996,GOA:P9WLI1,InterPro:IPR025445,NCBI_GP:CCP44996.1;Name=CCP44996.1;Note=Rv2219%2C (MTCY190.30)%2C len: 250 aa. Probable conserved transmembrane protein. Equivalent to hypothetical membrane protein ML0857 (250 aa) from Mycobacterium leprae Z98741 |MLCB22_13 Mycobacterium leprae cosmid B22%3B H (250 aa) opt : 1328%2C E(): 0%3B 80.8%25 identity in 250 aa overlap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2219;product=Probable conserved transmembrane protein;protein_id=CCP44996.1;transl_table=11
AL123456.3	EMBL	gene	2486994	2487416	.	-	.	ID=gene-Rv2219A;Name=Rv2219A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2219A
AL123456.3	EMBL	CDS	2486994	2487416	.	-	0	ID=cds-CCP44997.1;Parent=gene-Rv2219A;Dbxref=EnsemblGenomes-Gn:Rv2219A,EnsemblGenomes-Tr:CCP44997,InterPro:IPR010432,InterPro:IPR016795,UniProtKB/TrEMBL:Q79FG7,NCBI_GP:CCP44997.1;Name=CCP44997.1;Note=Rv2219A%2C len: 140 aa. Probable conserved membrane protein%2C similar to SC3H12.05c|AL355740_5 possible integral membrane protein from Streptomyces coelicolor (155 aa)%2CFASTA scores: opt: 327%2C E(): 7.5e-14%2C (46.6%25 identity in 133 aa overlap)%2C also linked to glnA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2219A;product=Probable conserved membrane protein;protein_id=CCP44997.1;transl_table=11
AL123456.3	EMBL	gene	2487615	2489051	.	+	.	ID=gene-Rv2220;Name=glnA1;gbkey=Gene;gene=glnA1;gene_biotype=protein_coding;gene_synonym=glnA;locus_tag=Rv2220
AL123456.3	EMBL	CDS	2487615	2489051	.	+	0	ID=cds-CCP44998.1;Parent=gene-Rv2220;Dbxref=EnsemblGenomes-Gn:Rv2220,EnsemblGenomes-Tr:CCP44998,GOA:P9WN39,InterPro:IPR001637,InterPro:IPR004809,InterPro:IPR008146,InterPro:IPR008147,InterPro:IPR014746,InterPro:IPR027302,InterPro:IPR027303,PDB:1HTO,PDB:1HTQ,PDB:2BVC,PDB:2WGS,PDB:2WHI,PDB:3ZXR,PDB:3ZXV,PDB:4ACF,NCBI_GP:CCP44998.1;Name=CCP44998.1;Note=Rv2220%2C (MTCY190.31%2C MTCY427.01)%2C len: 478 aa. glnA1%2C glutamine synthetase class I (see Tullius et al.%2C2001)%2C similar to many e.g. GLNA_STRCO|P15106 from Streptomyces coelicolor%2C FASTA score: (71.4%25 identity in 475 aa overlap)%3B etc. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2222c|glnA2%2C Rv2860c|glnA4%2C and Rv1878|glnA3. Contains PS00180 Glutamine synthetase signature 1%2C PS00181 Glutamine synthetase putative ATP-binding region signature%2C and PS00182 Glutamine synthetase class-I adenylation site. Belongs to the glutamine synthetase family. Note has shown to be essential for M. tuberculosis virulence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnA1;inference=protein motif:PROSITE:PS00182;locus_tag=Rv2220;product=Glutamine synthetase GlnA1 (glutamine synthase) (GS-I);protein_id=CCP44998.1;transl_table=11
AL123456.3	EMBL	gene	2489369	2492353	.	-	.	ID=gene-Rv2221c;Name=glnE;gbkey=Gene;gene=glnE;gene_biotype=protein_coding;locus_tag=Rv2221c
AL123456.3	EMBL	CDS	2489369	2492353	.	-	0	ID=cds-CCP44999.1;Parent=gene-Rv2221c;Dbxref=EnsemblGenomes-Gn:Rv2221c,EnsemblGenomes-Tr:CCP44999,GOA:P9WN27,InterPro:IPR005190,InterPro:IPR013546,InterPro:IPR023057,NCBI_GP:CCP44999.1;Name=CCP44999.1;Note=Rv2221c%2C (MTCY190.32c%2C MTCY427.02c)%2C len: 994 aa. glnE%2C glutamate-ammonia-ligase adenylyltransferase (see citations below)%2C similar to others e.g. GLNE_ECOLI|P30870 glutamate-ammonia-ligase adenylyltransferase from Escherichia coli%2C FASTA score: (24.4%25 identity in 721 aa overlap)%3B GLNE_HAEIN|P44419 Glutamate-ammonia-ligase adenylyltransferase from Haemophilus influenzae (981 aa)%2CFASTA score: (28.1%25 identity in 199 aa overlap)%3B etc. Note that initiation codon uncertain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnE;locus_tag=Rv2221c;product=Glutamate-ammonia-ligase adenylyltransferase GlnE (glutamine-synthetase adenylyltransferase);protein_id=CCP44999.1;transl_table=11
AL123456.3	EMBL	gene	2492402	2493742	.	-	.	ID=gene-Rv2222c;Name=glnA2;gbkey=Gene;gene=glnA2;gene_biotype=protein_coding;locus_tag=Rv2222c
AL123456.3	EMBL	CDS	2492402	2493742	.	-	0	ID=cds-CCP45000.1;Parent=gene-Rv2222c;Dbxref=EnsemblGenomes-Gn:Rv2222c,EnsemblGenomes-Tr:CCP45000,GOA:P9WN37,InterPro:IPR008146,InterPro:IPR008147,InterPro:IPR014746,InterPro:IPR027303,NCBI_GP:CCP45000.1;Name=CCP45000.1;Note=Rv2222c%2C (MTCY427.03c)%2C len: 446 aa. Probable glnA2%2Cglutamine synthetase class II%2C similar to others. Also similar to three other potential glutamine synthetases in Mycobacterium tuberculosis: Rv2220|glnA1%2C Rv2860c|glnA4%2Cand Rv1878|glnA3. Belongs to the glutamine synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnA2;locus_tag=Rv2222c;product=Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II);protein_id=CCP45000.1;transl_table=11
AL123456.3	EMBL	repeat_region	2493801	2493818	.	+	.	ID=id-AL123456.3:2493801..2493818;Note=18 bp inverted repeat between 3' end of MTCY427.04c and 5' end of MTCY427.03c;gbkey=repeat_region
AL123456.3	EMBL	gene	2493837	2495399	.	-	.	ID=gene-Rv2223c;Name=Rv2223c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2223c
AL123456.3	EMBL	CDS	2493837	2495399	.	-	0	ID=cds-CCP45001.1;Parent=gene-Rv2223c;Dbxref=EnsemblGenomes-Gn:Rv2223c,EnsemblGenomes-Tr:CCP45001,GOA:P9WHR5,InterPro:IPR000073,InterPro:IPR013595,InterPro:IPR029058,NCBI_GP:CCP45001.1;Name=CCP45001.1;Note=Rv2223c%2C (MTCY427.04c)%2C len: 520 aa. Probable exported protease %3B has signal sequence. Very similar to three proteases/peptidases from Streptomyces spp.: L42758%2CL42759%2C L27466. FASTA score: L42758|STMSLPD STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): 0%2C (37.5%25 identity in 533 aa overlap). Also similar to hypothetical proteins YZZE _ECOLI|P34211 from Escherichia coli (25.4%25 identity in 406 aa overlap) and PIR:B36944 in ompP 3' region (27.5%25 identity in 218 aa overlap). Highly similar to Rv2224c and Rv2672 (49.3%25 identity in 507 aa overlap)%3B contains PS00120 Lipases%2C serine active site. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv2223c;product=Probable exported protease;protein_id=CCP45001.1;transl_table=11
AL123456.3	EMBL	gene	2495461	2497023	.	-	.	ID=gene-Rv2224c;Name=caeA;gbkey=Gene;gene=caeA;gene_biotype=protein_coding;locus_tag=Rv2224c
AL123456.3	EMBL	CDS	2495461	2497023	.	-	0	ID=cds-CCP45002.1;Parent=gene-Rv2224c;Dbxref=EnsemblGenomes-Gn:Rv2224c,EnsemblGenomes-Tr:CCP45002,GOA:P9WHR3,InterPro:IPR000073,InterPro:IPR029058,NCBI_GP:CCP45002.1;Name=CCP45002.1;Note=Rv2224c%2C (MTCY427.05c)%2C len: 520 aa. Probable caeA%2Ccarboxylesterase%3B has signal sequence and lipoprotein motif at N-terminal end. Very similar to three proteases/peptidases from Streptomyces spp.: L42758%2CL42759%2C L27466. FASTA score: L4 2758|STMSLPD STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): 0%2C (37.5%25 identity in 533 aa overlap). Similar to hypothetical protein SW:YZZE_ECOLI P34211 (27.7%25 identity in 412 aa overlap) and highly similar to Rv2224c and Rv2672 (49.3%25 identity in 507 aa overlap)%3B contains PS00013%2C Prokaryotic membrane lipoprotein lipid attachment site%2C and PS00120 Lipases%2C serine active site. Conserved in M. tuberculosis%2CM. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007). Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=caeA;inference=protein motif:PROSITE:PS00120;locus_tag=Rv2224c;product=Probable carboxylesterase CaeA;protein_id=CCP45002.1;transl_table=11
AL123456.3	EMBL	gene	2497742	2498587	.	+	.	ID=gene-Rv2225;Name=panB;gbkey=Gene;gene=panB;gene_biotype=protein_coding;locus_tag=Rv2225
AL123456.3	EMBL	CDS	2497742	2498587	.	+	0	ID=cds-CCP45003.1;Parent=gene-Rv2225;Dbxref=EnsemblGenomes-Gn:Rv2225,EnsemblGenomes-Tr:CCP45003,GOA:P9WIL7,InterPro:IPR003700,InterPro:IPR015813,PDB:1OY0,NCBI_GP:CCP45003.1;Name=CCP45003.1;Note=Rv2225%2C (MTCY427.06)%2C len: 281 aa. panB%2C3-methyl-2-oxobutanoate hydroxymethyltransferase%2C similar to PANB_ECOLI|P31057 3-methyl-2-oxobutanoate hydroxymethyltransferase from Escherichia coli (45.9%25 identity in 257 aa overlap). Identified as a substrate for proteasomal degradation (See Pearce et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=panB;locus_tag=Rv2225;product=3-methyl-2-oxobutanoate hydroxymethyltransferase PanB;protein_id=CCP45003.1;transl_table=11
AL123456.3	EMBL	gene	2498832	2500373	.	+	.	ID=gene-Rv2226;Name=Rv2226;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2226
AL123456.3	EMBL	CDS	2498832	2500373	.	+	0	ID=cds-CCP45004.1;Parent=gene-Rv2226;Dbxref=EnsemblGenomes-Gn:Rv2226,EnsemblGenomes-Tr:CCP45004,GOA:P9WLH9,InterPro:IPR007899,InterPro:IPR023577,NCBI_GP:CCP45004.1;Name=CCP45004.1;Note=Rv2226%2C (MTCY427.07)%2C len: 513 aa. Conserved protein%2C similar to hypothetical secreted protein (510 aa) from Streptomyces coelicolor A3(2) emb|CAB59601.1| (AL132662) hypothetical secreted protein [Streptomyces coelicolor. Smith-Waterman scores Expect %3D 5e-44 Identities %3D 166/506 (32%25);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2226;product=Conserved protein;protein_id=CCP45004.1;transl_table=11
AL123456.3	EMBL	gene	2500445	2500751	.	-	.	ID=gene-rnpB;Name=rnpB;gbkey=Gene;gene=rnpB;gene_biotype=misc_RNA
AL123456.3	EMBL	transcript	2500445	2500751	.	-	.	ID=rna-rnpB;Parent=gene-rnpB;Note=rnpB%2C rna component of RNase P.;gbkey=misc_RNA;gene=rnpB;product=Ribonuclease P RNA
AL123456.3	EMBL	exon	2500445	2500751	.	-	.	ID=exon-rnpB-1;Parent=rna-rnpB;Note=rnpB%2C rna component of RNase P.;gbkey=misc_RNA;gene=rnpB;product=Ribonuclease P RNA
AL123456.3	EMBL	gene	2500931	2501632	.	+	.	ID=gene-Rv2227;Name=Rv2227;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2227
AL123456.3	EMBL	CDS	2500931	2501632	.	+	0	ID=cds-CCP45005.1;Parent=gene-Rv2227;Dbxref=EnsemblGenomes-Gn:Rv2227,EnsemblGenomes-Tr:CCP45005,InterPro:IPR018655,NCBI_GP:CCP45005.1;Name=CCP45005.1;Note=Rv2227%2C (MTCY427.08)%2C len: 233 aa. Conserved hypothetical protein%2C similar to conserved hypothetical proteins from various bacteria e.g. gb|AAK22693.1| (AE005746) conserved hypothetical protein from Caulobacter crescentus (234 aa) Smith-Waterman score %3D 109 bits (429)%2CExpect %3D 1e-41 Identities %3D 83/167 (49%25);gbkey=CDS;locus_tag=Rv2227;product=Conserved hypothetical protein;protein_id=CCP45005.1;transl_table=11
AL123456.3	EMBL	gene	2501644	2502738	.	-	.	ID=gene-Rv2228c;Name=Rv2228c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2228c
AL123456.3	EMBL	CDS	2501644	2502738	.	-	0	ID=cds-CCP45006.1;Parent=gene-Rv2228c;Dbxref=EnsemblGenomes-Gn:Rv2228c,EnsemblGenomes-Tr:CCP45006,GOA:P9WLH5,InterPro:IPR002156,InterPro:IPR012337,InterPro:IPR013078,InterPro:IPR014636,InterPro:IPR029033,PDB:3HST,NCBI_GP:CCP45006.1;Name=CCP45006.1;Note=Rv2228c%2C (MTCY427.09c)%2C len: 364 aa. Multifunctional protein with RNase H%2C alpha-ribazole phosphatase%2C and acid phosphatase activities. Some similarity to phosphoglycerate mutase and ribonuclease H. Similar to CAB88177.1|AL352972 putative bifunctional protein (ribonuclease H/phosphoglycerate mutase) from Streptomyces coelicolor A3(2) (497 aa)%3B Smith-Waterman scores: 107 bits (424)%2CExpect %3D 4e-41 Identities %3D 160/485 (32%25). Also similar in C-terminal part to Rv2419c and Rv2135c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2228c;product=Multifunctional protein. Has RNASE H%2Calpha-ribazole phosphatase%2C and acid phosphatase activities.;protein_id=CCP45006.1;transl_table=11
AL123456.3	EMBL	gene	2502735	2503472	.	-	.	ID=gene-Rv2229c;Name=Rv2229c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2229c
AL123456.3	EMBL	CDS	2502735	2503472	.	-	0	ID=cds-CCP45007.1;Parent=gene-Rv2229c;Dbxref=EnsemblGenomes-Gn:Rv2229c,EnsemblGenomes-Tr:CCP45007,GOA:P9WLH3,InterPro:IPR003743,NCBI_GP:CCP45007.1;Name=CCP45007.1;Note=Rv2229c%2C (MTCY427.10c)%2C len: 245 aa. Conserved protein%3B probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium leprae ML1638 (232 aa)%2C FASTA scores: opt: 868 E(): 4.4e-43%3B 60.870%25 identity in 230 aa overlap emb|CAC30589.1| (AL583922). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2229c;product=Conserved protein;protein_id=CCP45007.1;transl_table=11
AL123456.3	EMBL	gene	2503469	2504608	.	-	.	ID=gene-Rv2230c;Name=Rv2230c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2230c
AL123456.3	EMBL	CDS	2503469	2504608	.	-	0	ID=cds-CCP45008.1;Parent=gene-Rv2230c;Dbxref=EnsemblGenomes-Gn:Rv2230c,EnsemblGenomes-Tr:CCP45008,GOA:P9WFM1,InterPro:IPR002678,InterPro:IPR017221,NCBI_GP:CCP45008.1;Name=CCP45008.1;Note=Rv2230c%2C (MTCY427.11c)%2C len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae%2C ML1639%2Cconserved hypothetical protein (385 aa). Similar to hypothetical proteins from B. subtilis%2C P54472%2C and L. monocytogenes%2C P53434. FASTA score: ML1639 (MLCB1243.36) opt: 2088%2C E(): 4e-107%3B 79.481%25 identity in 385 aa overlap same as >pir||T44719 hypothetical protein MLCB1243.36 [imported] - Mycobacterium leprae >gi|3150237|emb|CAA19217.1| (AL023635)%3B P54472|YQFO_BACSU hypothetical 30. 7 kDa protein in (279 aa) opt: 604%3B E(): 2.2e-30%3B 38.8%25 identity in 258 aa overlap. P53434|YRP2_LISMO hypothetical 41.4 kDa protein (373 aa) opt: 595%2C E(): 1e-29%3B 30.7%25 identity in 326 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2230c;product=Conserved protein;protein_id=CCP45008.1;transl_table=11
AL123456.3	EMBL	gene	2504605	2505699	.	-	.	ID=gene-Rv2231c;Name=cobC;gbkey=Gene;gene=cobC;gene_biotype=protein_coding;locus_tag=Rv2231c
AL123456.3	EMBL	CDS	2504605	2505699	.	-	0	ID=cds-CCP45009.1;Parent=gene-Rv2231c;Dbxref=EnsemblGenomes-Gn:Rv2231c,EnsemblGenomes-Tr:CCP45009,GOA:P9WQ89,InterPro:IPR004838,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP45009.1;Name=CCP45009.1;Note=Rv2231c%2C (MTCY427.12c)%2C len: 364 aa. Possible cobC%2Caminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC protein (333 aa) opt: 277%2C E(): 1.7e-11%3B 28.8%25 identity in 313 aa overlap and also to e.g. SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase (27.0%25 identity in 289 aa overlap)%2C contains PS00105 aminotransferases class-I pyridoxal-phosphate attachment site. Real Mycobacterium tuberculosis histidinol-phosphate aminotransferase%2C hisC%2C is Rv1600 (MTCY336.04c).;gbkey=CDS;gene=cobC;inference=protein motif:PROSITE:PS00105;locus_tag=Rv2231c;product=Possible aminotransferase CobC;protein_id=CCP45009.1;transl_table=11
AL123456.3	EMBL	gene	2505736	2506161	.	-	.	ID=gene-Rv2231A;Name=vapC16;gbkey=Gene;gene=vapC16;gene_biotype=protein_coding;locus_tag=Rv2231A
AL123456.3	EMBL	CDS	2505736	2506161	.	-	0	ID=cds-CCP45010.1;Parent=gene-Rv2231A;Dbxref=EnsemblGenomes-Gn:Rv2231A,EnsemblGenomes-Tr:CCP45010,GOA:P0CV93,InterPro:IPR022907,NCBI_GP:CCP45010.1;Name=CCP45010.1;Note=Rv2231A%2C len: 141 aa. Possible vapC16%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv2231B (See Pandey and Gerdes%2C 2005). Nucleotide position 2505919 in the genome sequence has been corrected%2C A:G resulting in A81A.;gbkey=CDS;gene=vapC16;locus_tag=Rv2231A;product=Possible toxin VapC16;protein_id=CCP45010.1;transl_table=11
AL123456.3	EMBL	gene	2506207	2506383	.	-	.	ID=gene-Rv2231B;Name=vapB16;gbkey=Gene;gene=vapB16;gene_biotype=protein_coding;locus_tag=Rv2231B
AL123456.3	EMBL	CDS	2506207	2506383	.	-	0	ID=cds-CCP45011.1;Parent=gene-Rv2231B;Dbxref=EnsemblGenomes-Gn:Rv2231B,EnsemblGenomes-Tr:CCP45011,NCBI_GP:CCP45011.1;Name=CCP45011.1;Note=Rv2231B%2C len: 58 aa. Possible vapB16%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv2231A (See Pandey and Gerdes%2C 2005).;gbkey=CDS;gene=vapB16;locus_tag=Rv2231B;product=Possible antitoxin VapB16;protein_id=CCP45011.1;transl_table=11
AL123456.3	EMBL	gene	2506278	2507153	.	+	.	ID=gene-Rv2232;Name=ptkA;gbkey=Gene;gene=ptkA;gene_biotype=protein_coding;locus_tag=Rv2232
AL123456.3	EMBL	CDS	2506278	2507153	.	+	0	ID=cds-CCP45012.1;Parent=gene-Rv2232;Dbxref=EnsemblGenomes-Gn:Rv2232,EnsemblGenomes-Tr:CCP45012,GOA:P9WPI9,InterPro:IPR023198,InterPro:IPR023214,NCBI_GP:CCP45012.1;Name=CCP45012.1;Note=Rv2232%2C (MTCY427.13)%2C len: 291 aa. PtkA%2C protein tyrosine kinase%2C similar to members of haloacid dehalogenase-like family from several bacteria and to putative phosphatases e.g. Q9I767 and AAK78398. Contains N-terminal extension. FASTA scores: Q9I767 hypothetical protein PA0065 (221 aa) opt: 439 E(): 3.2e-18%3B 38.679%25 identity (40.196%25 ungapped) in 212 aa overlap%3B >>tr|AAK78398 Predicted phosphatase%2C had family (216 aa) opt: 427%2C E(): 1.5e-17%3B 34.762%25 identity (35.437%25 ungapped) in 210 aa overlap. Replaces previous Rv2232 and Rv2233. Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;gene=ptkA;locus_tag=Rv2232;product=Protein tyrosine kinase transcriptional regulatory protein PtkA;protein_id=CCP45012.1;transl_table=11
AL123456.3	EMBL	gene	2507146	2507637	.	+	.	ID=gene-Rv2234;Name=ptpA;gbkey=Gene;gene=ptpA;gene_biotype=protein_coding;gene_synonym=MPtpA;locus_tag=Rv2234
AL123456.3	EMBL	CDS	2507146	2507637	.	+	0	ID=cds-CCP45013.1;Parent=gene-Rv2234;Dbxref=EnsemblGenomes-Gn:Rv2234,EnsemblGenomes-Tr:CCP45013,GOA:P9WIA1,InterPro:IPR000106,InterPro:IPR017867,InterPro:IPR023485,PDB:1U2P,PDB:1U2Q,PDB:1ZOJ,PDB:2LUO,NCBI_GP:CCP45013.1;Name=CCP45013.1;Note=Rv2234%2C (MTCY427.15)%2C len: 163 aa. PtpA (alternate gene name: MPtpA)%2C low molecular weight protein-tyrosine-phosphatase (see citations below)%2C similar to other phosphotyrosine protein phosphatases e.g. P53433|PTPA_STRCO low molecular weight protein-tyrosine phosphatase from Streptomyces coelicolor (164 aa)%2C FASTA scores: opt: 455%2C E(): 3.3e -25%2C (49.7%25 identity in 155 aa overlap)%3B PA1S_HUMAN|P24667 red cell acid phosphatase 1%2CFASTA score: (37.7%25 identity in 138 aa overlap)%3B etc. Contains a phosphatase catalytic site domain located in N-terminal part. Activity proven biochemically. Supposed a secreted protein. Substrate of PtkA|Rv2232.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ptpA;locus_tag=Rv2234;product=Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase);protein_id=CCP45013.1;transl_table=11
AL123456.3	EMBL	gene	2507637	2508452	.	+	.	ID=gene-Rv2235;Name=Rv2235;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2235
AL123456.3	EMBL	CDS	2507637	2508452	.	+	0	ID=cds-CCP45014.1;Parent=gene-Rv2235;Dbxref=EnsemblGenomes-Gn:Rv2235,EnsemblGenomes-Tr:CCP45014,GOA:P9WGA7,InterPro:IPR002994,NCBI_GP:CCP45014.1;Name=CCP45014.1;Note=Rv2235%2C (MTCY427.16)%2C len: 271 aa. Probable conserved transmembrane protein (see Miller %26 Shinnick 2001)%3B hydrophobic regions near N- and C-terminus. Similar to conserved membrane proteins in other Actinomycetes. Equivalent to Mycobacterium leprae. ML1644 (270 aa). FASTA scores: opt: 1357%2C E(): 1.2e-72%3B 74.170%25 identity in 271 aa overlap T44717|3150235|CAA19213.1|AL023635 13093419|CAC30595.1|AL583922. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2235;product=Probable conserved transmembrane protein;protein_id=CCP45014.1;transl_table=11
AL123456.3	EMBL	gene	2508434	2509375	.	-	.	ID=gene-Rv2236c;Name=cobD;gbkey=Gene;gene=cobD;gene_biotype=protein_coding;locus_tag=Rv2236c
AL123456.3	EMBL	CDS	2508434	2509375	.	-	0	ID=cds-CCP45015.1;Parent=gene-Rv2236c;Dbxref=EnsemblGenomes-Gn:Rv2236c,EnsemblGenomes-Tr:CCP45015,GOA:P9WP93,InterPro:IPR004485,NCBI_GP:CCP45015.1;Name=CCP45015.1;Note=Rv2236c%2C (MTCY427.17c)%2C len: 313 aa. Probable cobD%2Ccobalamin biosynthesis transmembrane protein%2C similar to S52223 Rhodobacter capsulatus 945 protein BluD (39.0%25 identity in 287 aa overlap) involved in cobinamide synthesis%2C and to COBD_PSEDE Pseudomonas dentrificans cobD protein (37.5%25 identity in 269 aa overlap)%2C also CBIB_SALTY Salmonella typhimurum cbiB protein (35.5%25 identity in 304 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobD;locus_tag=Rv2236c;product=Probable cobalamin biosynthesis transmembrane protein CobD;protein_id=CCP45015.1;transl_table=11
AL123456.3	EMBL	gene	2509489	2510256	.	+	.	ID=gene-Rv2237;Name=Rv2237;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2237
AL123456.3	EMBL	CDS	2509489	2510256	.	+	0	ID=cds-CCP45016.1;Parent=gene-Rv2237;Dbxref=EnsemblGenomes-Gn:Rv2237,EnsemblGenomes-Tr:CCP45016,GOA:P9WLH1,InterPro:IPR018713,NCBI_GP:CCP45016.1;Name=CCP45016.1;Note=Rv2237%2C (MTCY427.18)%2C len: 255 aa. Conserved protein. Similar to Mycobacterium tuberculosis hypothetical proteins Rv0276%2C Rv0826%2C Rv1645c. FASTA score: Rv0276 gp|AL021930|MTV035_4 (306 aa) opt: 874%2C E(): 0%3B 49.6%25 identity in 282 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2237;product=Conserved protein;protein_id=CCP45016.1;transl_table=11
AL123456.3	EMBL	gene	2510351	2510587	.	-	.	ID=gene-Rv2237A;Name=Rv2237A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2237A
AL123456.3	EMBL	CDS	2510351	2510587	.	-	0	ID=cds-CCP45017.1;Parent=gene-Rv2237A;Dbxref=EnsemblGenomes-Gn:Rv2237A,EnsemblGenomes-Tr:CCP45017,UniProtKB/TrEMBL:I6XDU8,NCBI_GP:CCP45017.1;Name=CCP45017.1;Note=Rv2237A%2C len: 78 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2237A;product=Conserved protein;protein_id=CCP45017.1;transl_table=11
AL123456.3	EMBL	gene	2510598	2510669	.	-	.	ID=gene-valV;Name=valV;gbkey=Gene;gene=valV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2510598	2510669	.	-	.	ID=rna-valV;Parent=gene-valV;Note=codon recognized: GUA%3B valV%2C tRNA-Val%2C anticodon tac%2C length %3D 72;anticodon=(pos:complement(2510635..2510637));gbkey=tRNA;gene=valV;product=tRNA-Val
AL123456.3	EMBL	exon	2510598	2510669	.	-	.	ID=exon-valV-1;Parent=rna-valV;Note=codon recognized: GUA%3B valV%2C tRNA-Val%2C anticodon tac%2C length %3D 72;anticodon=(pos:complement(2510635..2510637));gbkey=tRNA;gene=valV;product=tRNA-Val
AL123456.3	EMBL	gene	2510715	2511176	.	-	.	ID=gene-Rv2238c;Name=ahpE;gbkey=Gene;gene=ahpE;gene_biotype=protein_coding;locus_tag=Rv2238c
AL123456.3	EMBL	CDS	2510715	2511176	.	-	0	ID=cds-CCP45018.1;Parent=gene-Rv2238c;Dbxref=EnsemblGenomes-Gn:Rv2238c,EnsemblGenomes-Tr:CCP45018,GOA:P9WIE3,InterPro:IPR000866,InterPro:IPR012336,InterPro:IPR024706,PDB:1XVW,PDB:1XXU,NCBI_GP:CCP45018.1;Name=CCP45018.1;Note=Rv2238c%2C (MTCY427.19c)%2C len: 153 aa. Probable ahpE%2Cperoxiredoxin. Similarity to many members of AHPC/TSA family e.g. sp|Q96291|BAS1_ARATH 2-CYS peroxiredoxin BAS1 precursor (265 aa). FASTA score: opt: 275%2C E(): 2.7e-12%3B 35.0%25 identity in 143 aa overlap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ahpE;locus_tag=Rv2238c;product=Probable peroxiredoxin AhpE;protein_id=CCP45018.1;transl_table=11
AL123456.3	EMBL	gene	2511176	2511652	.	-	.	ID=gene-Rv2239c;Name=Rv2239c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2239c
AL123456.3	EMBL	CDS	2511176	2511652	.	-	0	ID=cds-CCP45019.1;Parent=gene-Rv2239c;Dbxref=EnsemblGenomes-Gn:Rv2239c,EnsemblGenomes-Tr:CCP45019,InterPro:IPR021412,NCBI_GP:CCP45019.1;Name=CCP45019.1;Note=Rv2239c%2C (MTCY427.20c)%2C len: 158 aa. Conserved hypothetical protein%2C similar to conserved hypothetical proteins from Mycobacterium leprae (ML1649%2C 140 aa) and Streptomyces coelicolor A3(2) (SCC8A.28c%2C 159 aa). Equivalent to ML1649 conserved hypothetical protein (140 aa). FASTA scores: ML1649 conserved hypothetical protein (140 aa) opt: 846%2C E(): 6.5e-45%3B 86.429%25 identity in 140 aa overlap (tr|O69479|O69479 hypothetical 15.2 KDA protein (140 aa)%3B and opt: 447%2C E(): 1.2e-21%3B 50.355%25 identity (51.825%25 ungapped) in 141 aa overlap. Similarity with ML1649 suggests alternative start at 251198.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2239c;product=Conserved hypothetical protein;protein_id=CCP45019.1;transl_table=11
AL123456.3	EMBL	gene	2511690	2512280	.	-	.	ID=gene-Rv2240c;Name=Rv2240c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2240c
AL123456.3	EMBL	CDS	2511690	2512280	.	-	0	ID=cds-CCP45020.1;Parent=gene-Rv2240c;Dbxref=EnsemblGenomes-Gn:Rv2240c,EnsemblGenomes-Tr:CCP45020,GOA:P9WLG7,NCBI_GP:CCP45020.1;Name=CCP45020.1;Note=Rv2240c%2C (MTCY427.21c)%2C len: 196 aa. Unknown protein. Start changed since first submission (-69 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2240c;product=Unknown protein;protein_id=CCP45020.1;transl_table=11
AL123456.3	EMBL	gene	2512539	2515244	.	+	.	ID=gene-Rv2241;Name=aceE;gbkey=Gene;gene=aceE;gene_biotype=protein_coding;locus_tag=Rv2241
AL123456.3	EMBL	CDS	2512539	2515244	.	+	0	ID=cds-CCP45021.1;Parent=gene-Rv2241;Dbxref=EnsemblGenomes-Gn:Rv2241,EnsemblGenomes-Tr:CCP45021,GOA:P9WIS9,InterPro:IPR004660,InterPro:IPR005474,InterPro:IPR009014,InterPro:IPR029061,NCBI_GP:CCP45021.1;Name=CCP45021.1;Note=Rv2241%2C (MTCY427.22)%2C len: 901 aa. AceE%2C pyruvate dehydrogenase E1 component%2C similar to others e.g. ODP1_ECOLI|P06958 pyruvate dehydrogenase E1 component from Escherichia coli%2C FASTA score: (51.2%25 identity in 891 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aceE;locus_tag=Rv2241;product=Pyruvate dehydrogenase E1 component AceE (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase);protein_id=CCP45021.1;transl_table=11
AL123456.3	EMBL	gene	2515304	2516548	.	+	.	ID=gene-Rv2242;Name=Rv2242;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2242
AL123456.3	EMBL	CDS	2515304	2516548	.	+	0	ID=cds-CCP45022.1;Parent=gene-Rv2242;Dbxref=EnsemblGenomes-Gn:Rv2242,EnsemblGenomes-Tr:CCP45022,GOA:P9WPH5,InterPro:IPR009057,InterPro:IPR025736,NCBI_GP:CCP45022.1;Name=CCP45022.1;Note=Rv2242%2C (MTCY427.23)%2C len: 414 aa. Conserved hypothetical protein. Equivalent to ML1652 conserved hypothetical protein from Mycobacterium leprae (414 aa)%2Cand orthologue in Streptomyces coelicolor A3(2). FASTA scores: ML1652 opt: 2369%2C E(): 4.2e-128%3B 88.406%25 identity in 414 aa overlap (AL023635)(AL583922). Some similarity at 3' end with S25203 srmR protein - Streptomyces ambofaciens (604 aa) opt: 188 E(): 9e-05%3B (26.4%25 identity in 277 aa overlap) and with SW:YAEG_HAEIN P44509 hypothetical protein HI0093 (42.3%25 identity in 52 aa overlap). Contains possible helix-turn-helix motif at aa 360-381 (+3.52 SD);gbkey=CDS;locus_tag=Rv2242;product=Conserved hypothetical protein;protein_id=CCP45022.1;transl_table=11
AL123456.3	EMBL	gene	2516787	2517695	.	+	.	ID=gene-Rv2243;Name=fabD;gbkey=Gene;gene=fabD;gene_biotype=protein_coding;gene_synonym=mtFabD;locus_tag=Rv2243
AL123456.3	EMBL	CDS	2516787	2517695	.	+	0	ID=cds-CCP45023.1;Parent=gene-Rv2243;Dbxref=EnsemblGenomes-Gn:Rv2243,EnsemblGenomes-Tr:CCP45023,GOA:P9WNG5,InterPro:IPR001227,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,PDB:2QC3,PDB:2QJ3,NCBI_GP:CCP45023.1;Name=CCP45023.1;Note=Rv2243%2C (MTCY427.24)%2C len: 302 aa. FabD (alternate gene name: mtFabD)%2C malonyl CoA-acyl carrier protein transacylase (see citations below)%2C highly similar to e.g. A57356 acyl-CoA carrier protein malonyltransferase from Streptomyces coelicolor (316 aa)%2C FASTA score: opt: 955%2CE(): 0%2C (52.6%25 identity in 304 aa overlap)%3B FABD_HAEIN|P43712 malonyl CoA-acyl carrier protein transacylase from Haemophilus influenzae%2C FASTA score: (30.5%25 identity in 308 aa overlap)%3B and FABD_ECOLI|P25715 from Escherichia coli%2C FASTA score: (31.4%25 identity in 309 aa overlap). Identified as a substrate for proteasomal degradation (See Pearce et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fabD;locus_tag=Rv2243;product=Malonyl CoA-acyl carrier protein transacylase FabD (malonyl CoA:ACPM acyltransferase) (MCT);protein_id=CCP45023.1;transl_table=11
AL123456.3	EMBL	gene	2517032	2517134	.	-	.	ID=gene-mcr16;Name=mcr16;gbkey=Gene;gene=mcr16;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	2517032	2517134	.	-	.	ID=rna-mcr16;Parent=gene-mcr16;Note=mcr16%2C putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~100 nt band detected by Northern blot.;gbkey=ncRNA;gene=mcr16;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	2517032	2517134	.	-	.	ID=exon-mcr16-1;Parent=rna-mcr16;Note=mcr16%2C putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~100 nt band detected by Northern blot.;gbkey=ncRNA;gene=mcr16;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	2517771	2518118	.	+	.	ID=gene-Rv2244;Name=acpM;gbkey=Gene;gene=acpM;gene_biotype=protein_coding;locus_tag=Rv2244
AL123456.3	EMBL	CDS	2517771	2518118	.	+	0	ID=cds-CCP45024.1;Parent=gene-Rv2244;Dbxref=EnsemblGenomes-Gn:Rv2244,EnsemblGenomes-Tr:CCP45024,GOA:P9WQF3,InterPro:IPR003231,InterPro:IPR009081,PDB:1KLP,NCBI_GP:CCP45024.1;Name=CCP45024.1;Note=Rv2244%2C (MT2304%2C MTCY427.25)%2C len: 115 aa. AcpM%2Cacyl carrier protein%2C meromycolate precursor transport%2Cinvolved in meromycolate extension (see citations below). Highly similar to others e.g. L43074|STMFABD2|STMFABD|g870805 acyl carrier protein from Streptomyces glaucescens (82 aa)%2C FASTA scores: opt: 298%2CE(): 8.4e-13%2C (56.6%25 identity in 76 aa overlap)%3B and ACP_ECOLI|P02901 acyl carrier protein from Escherichia coli%2C FASTA score: (37.3%25 identity in 67 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=acpM;locus_tag=Rv2244;product=Meromycolate extension acyl carrier protein AcpM;protein_id=CCP45024.1;transl_table=11
AL123456.3	EMBL	gene	2518115	2519365	.	+	.	ID=gene-Rv2245;Name=kasA;gbkey=Gene;gene=kasA;gene_biotype=protein_coding;locus_tag=Rv2245
AL123456.3	EMBL	CDS	2518115	2519365	.	+	0	ID=cds-CCP45025.1;Parent=gene-Rv2245;Dbxref=EnsemblGenomes-Gn:Rv2245,EnsemblGenomes-Tr:CCP45025,GOA:P9WQD9,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR016038,InterPro:IPR016039,PDB:2WGD,PDB:2WGE,PDB:2WGF,PDB:2WGG,NCBI_GP:CCP45025.1;Name=CCP45025.1;Note=Rv2245%2C (MTCY427.26)%2C len: 416 aa. KasA%2Cbeta-ketoacyl-ACP synthase%2C involved in meromycolate extension (see citations below): belongs to the fas-II system%2C which utilizes primarily palmitoyl-ACP rather than short-chain acyl-ACP primers. Highly similar to others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP synthase from Streptomyces glaucescens (423 aa)%2C FASTA scores: opt: 1105%2CE(): 0%2C (44.6%25 identity in 417 aa overlap)%3B FABF_ECOLI|P39435 3-oxoacyl-[acyl-carrier-protein] synthase II from Escherichia coli%2C FASTA score: (39.4%25 identity in 254 aa overlap)%3B FABB_HORVU|P23902 3-oxoacyl-[acyl-carrier-protein] synthase I%2C FASTA score: (33.4%25 identity in 413 aa overlap)%3B etc. Strongest similarity to downstream ORF kasB|Rv2246|MTCY427.27 3-oxoacyl-[acyl-carrier-protein] synthase 2 from Mycobacterium tuberculosis (438 aa)%2C FASTA score: (66.3%25 identity in 409 aa overlap). Belongs to the beta-ketoacyl-ACP synthases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kasA;locus_tag=Rv2245;product=3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I);protein_id=CCP45025.1;transl_table=11
AL123456.3	EMBL	gene	2519396	2520712	.	+	.	ID=gene-Rv2246;Name=kasB;gbkey=Gene;gene=kasB;gene_biotype=protein_coding;locus_tag=Rv2246
AL123456.3	EMBL	CDS	2519396	2520712	.	+	0	ID=cds-CCP45026.1;Parent=gene-Rv2246;Dbxref=EnsemblGenomes-Gn:Rv2246,EnsemblGenomes-Tr:CCP45026,GOA:P9WQD7,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR016038,InterPro:IPR016039,PDB:2GP6,NCBI_GP:CCP45026.1;Name=CCP45026.1;Note=Rv2246%2C (MTCY427.27)%2C len: 438 aa. KasB%2Cbeta-ketoacyl-ACP synthase%2C involved in meromycolate extension (see citations below). Highly similar or similar to others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP synthase from Streptomyces glaucescens (423 aa)%2C FASTA scores: opt: 1091%2C E(): 0%2C (44.7%25 identity in 416 aa overlap)%3B FABF_ECOLI|P39435 3-oxoacyl-[acyl-carrier-protein] synthase II from Escherichia coli%2C FASTA score: (37.0%25 identity in 411 aa overlap)%3B FABB_HORVU|P23902 3-oxoacyl-[acyl-carrier-protein] synthase I%2C FASTA score: (32.5%25 identity in 415 aa overlap)%3B etc. Strongest similarity to upstream ORF Rv2245|kasA|MTCY427.26 3-oxoacyl-[acyl-carrier-protein] synthase 1 from Mycobacterium tuberculosis (416 aa)%2C FASTA score: (66.3%25 identity in 409 aa overlap). Belongs to the beta-ketoacyl-ACP synthases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kasB;locus_tag=Rv2246;product=3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I);protein_id=CCP45026.1;transl_table=11
AL123456.3	EMBL	gene	2520743	2522164	.	+	.	ID=gene-Rv2247;Name=accD6;gbkey=Gene;gene=accD6;gene_biotype=protein_coding;locus_tag=Rv2247
AL123456.3	EMBL	CDS	2520743	2522164	.	+	0	ID=cds-CCP45027.1;Parent=gene-Rv2247;Dbxref=EnsemblGenomes-Gn:Rv2247,EnsemblGenomes-Tr:CCP45027,GOA:P9WQH5,InterPro:IPR000022,InterPro:IPR011762,InterPro:IPR011763,InterPro:IPR029045,PDB:4L6W,NCBI_GP:CCP45027.1;Name=CCP45027.1;Note=Rv2247%2C (MTCY427.28)%2C len: 473 aa. AccD6%2CAcetyl/Propionyl CoA Carboxylase%2C beta subunit (see citations below)%2C highly similar to e.g. PCCB_RHOSO|Q06101 propionyl-CoA carboxylase beta chain%2C FASTA score: (75.1%25 identity in 437 aa overlap). Similar to many other Acetyl/Propionyl CoA Carboxylases from Mycobacterium tuberculosis. Belongs to the AccD / PccB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accD6;locus_tag=Rv2247;product=Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6;protein_id=CCP45027.1;transl_table=11
AL123456.3	EMBL	repeat_region	2522173	2522230	.	+	.	ID=id-AL123456.3:2522173..2522230;Note=58 bp inverted repeat near 3'end of MTCY427.28;gbkey=repeat_region
AL123456.3	EMBL	gene	2522360	2523175	.	+	.	ID=gene-Rv2248;Name=Rv2248;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2248
AL123456.3	EMBL	CDS	2522360	2523175	.	+	0	ID=cds-CCP45028.1;Parent=gene-Rv2248;Dbxref=EnsemblGenomes-Gn:Rv2248,EnsemblGenomes-Tr:CCP45028,GOA:P9WLG5,InterPro:IPR011335,NCBI_GP:CCP45028.1;Name=CCP45028.1;Note=Rv2248%2C (MTCY427.29)%2C len: 271 aa. Conserved hypothetical protein. Very similar to hypothetical M. tuberculosis proteins Rv3517%2C Rv1482c%2C Rv3555c%2C Rv3714c%2CRv1073. FASTA score: MTCY06G11.02c MTCY6G11 NID: g1877284 -(289 aa) opt: 366 E(): 5.3e-18%3B (32.1%25 identity in 249 aa overlap). Some similarity to Mycobacterium avium protein AF002133|AF0021 339 AF002133 NID: g2183254 (346 aa) opt: 308 E(): 5.2e-14%3B (28.3%25 identity in 254 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2248;product=Conserved hypothetical protein;protein_id=CCP45028.1;transl_table=11
AL123456.3	EMBL	repeat_region	2523184	2523236	.	+	.	ID=id-AL123456.3:2523184..2523236;Note=53 bp inverted repeat between 3' ends of MTCY427.29 and MT CY427.31c;gbkey=repeat_region
AL123456.3	EMBL	gene	2523241	2524791	.	-	.	ID=gene-Rv2249c;Name=glpD1;gbkey=Gene;gene=glpD1;gene_biotype=protein_coding;locus_tag=Rv2249c
AL123456.3	EMBL	CDS	2523241	2524791	.	-	0	ID=cds-CCP45029.1;Parent=gene-Rv2249c;Dbxref=EnsemblGenomes-Gn:Rv2249c,EnsemblGenomes-Tr:CCP45029,GOA:P9WN81,InterPro:IPR000447,InterPro:IPR006076,NCBI_GP:CCP45029.1;Name=CCP45029.1;Note=Rv2249c%2C (MTCY427.31c)%2C len: 516 aa. Probable glpD1%2Cglycerol-3-phosphate dehydrogenase%2C similar to SW:GLPD_ECOLI P13035 aerobic glycerol-3-phosphate dehydrogenase (30.0%25 identity in 486 aa overlap) and SW:GLPA_ECOLI P13032 anaerobic glycerol-3-phosphate dehydrogenase (28.2%25 identity in 504 aa overlap). Also similar to Rv3302c|glpD2 glycerol-3-phosphate dehydrogenase. Cofactor: FAD (by similarity). Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glpD1;locus_tag=Rv2249c;product=Probable glycerol-3-phosphate dehydrogenase GlpD1;protein_id=CCP45029.1;transl_table=11
AL123456.3	EMBL	gene	2524785	2525354	.	-	.	ID=gene-Rv2250c;Name=Rv2250c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2250c
AL123456.3	EMBL	CDS	2524785	2525354	.	-	0	ID=cds-CCP45030.1;Parent=gene-Rv2250c;Dbxref=EnsemblGenomes-Gn:Rv2250c,EnsemblGenomes-Tr:CCP45030,GOA:P9WMC5,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR023772,NCBI_GP:CCP45030.1;Name=CCP45030.1;Note=Rv2250c%2C (MTCY427.32c)%2C len: 189 aa. Possible transcriptional regulatory protein%2C TetR family. Start unclear%3B ORF has been shortened since first submission to avoid overlap with Rv2251 (-30 aa). Contains probable helix-turn-helix motif (Score 2243%2C +6.70 SD);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2250c;product=Possible transcriptional regulatory protein;protein_id=CCP45030.1;transl_table=11
AL123456.3	EMBL	gene	2525402	2525821	.	+	.	ID=gene-Rv2250A;Name=Rv2250A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2250A
AL123456.3	EMBL	CDS	2525402	2525821	.	+	0	ID=cds-CCP45031.1;Parent=gene-Rv2250A;Dbxref=EnsemblGenomes-Gn:Rv2250A,EnsemblGenomes-Tr:CCP45031,UniProtKB/TrEMBL:L0TBY6,NCBI_GP:CCP45031.1;Name=CCP45031.1;Note=Rv2250A%2C len: 139 aa. Conserved hypothetical protein%2C possibly flavoprotein. Similar to N-terminus of SCF91.28c|AL132973_28 possible flavoprotein from Streptomyces coelicolor (530 aa)%2C FASTA scores: opt: 240%2CE(): 1.1e-07%2C (39.25%25 identity in 107 aa overlap). Possible frameshift between nt 2525723 to 2525727. The sequences of CDC 1551 and Mycobacterium bovis are missing a single G base.;gbkey=CDS;locus_tag=Rv2250A;product=Possible flavoprotein;protein_id=CCP45031.1;transl_table=11
AL123456.3	EMBL	gene	2525565	2526992	.	+	.	ID=gene-Rv2251;Name=Rv2251;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2251
AL123456.3	EMBL	CDS	2525565	2526992	.	+	0	ID=cds-CCP45032.1;Parent=gene-Rv2251;Dbxref=EnsemblGenomes-Gn:Rv2251,EnsemblGenomes-Tr:CCP45032,GOA:L0TBR2,InterPro:IPR004113,InterPro:IPR006094,InterPro:IPR016164,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,InterPro:IPR016171,InterPro:IPR025650,UniProtKB/TrEMBL:L0TBR2,NCBI_GP:CCP45032.1;Name=CCP45032.1;Note=Rv2251%2C (MTV022.01)%2C len: 475 aa. Possible flavoprotein%2C probably continuation of Rv2250A%2C similar to MTCY164.18 from Mycobacterium tuberculosis and to several alkyldihydroxyacetonephosphate synthases (e.g. O00116). Also some similarity to D-lactate dehydrogenases. FASTA scores: sptr|O05784|O05784 hypothetical 56.5 kDa protein. (527 aa) opt: 1019 E(): 0%3B (38.6%25 identity in 487 aa overlap) and sp|O00116|ADAS_HUMAN alkyldihydroxyaceton ephosphate synthase precursor (658 aa) opt: 558 E(): 6.2e-27%3B (31.3%25 identity in 447 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2251;product=Possible flavoprotein;protein_id=CCP45032.1;transl_table=11
AL123456.3	EMBL	gene	2526989	2527918	.	+	.	ID=gene-Rv2252;Name=Rv2252;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2252
AL123456.3	EMBL	CDS	2526989	2527918	.	+	0	ID=cds-CCP45033.1;Parent=gene-Rv2252;Dbxref=EnsemblGenomes-Gn:Rv2252,EnsemblGenomes-Tr:CCP45033,GOA:P9WP29,InterPro:IPR001206,InterPro:IPR005218,InterPro:IPR016064,NCBI_GP:CCP45033.1;Name=CCP45033.1;Note=Rv2252%2C (MTV022.02)%2C len: 309 aa. Diacylglycerol kinase (See Owens et al.%2C 2006)%2C similar to hypothetical proteins from Bacillus subtilis (e.g. BSUB0004_120)%2CStreptomyces coelicolor A3(2) >emb|CAB61184.1| (AL132973) hypothetical protein SCF91.27c (293 aa) and P39074. FASTA scores: Z99107|BSUB0004_120 Bacillus subtilis complete genome (303 aa) opt: 397%2C E(): 1.7e-19%3B (26.4%25 identity in 299 aa overlap) and P390 74|BMRU_BACSU BMRU protein (297 aa) opt: 309%2C E(): 1.3e-13%3B (25.0%25 identity in 284 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2252;product=Diacylglycerol kinase;protein_id=CCP45033.1;transl_table=11
AL123456.3	EMBL	gene	2527984	2528487	.	+	.	ID=gene-Rv2253;Name=Rv2253;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2253
AL123456.3	EMBL	CDS	2527984	2528487	.	+	0	ID=cds-CCP45034.1;Parent=gene-Rv2253;Dbxref=EnsemblGenomes-Gn:Rv2253,EnsemblGenomes-Tr:CCP45034,GOA:O53527,UniProtKB/TrEMBL:O53527,NCBI_GP:CCP45034.1;Name=CCP45034.1;Note=Rv2253%2C (MTV022.03)%2C len: 167 aa. Possible secreted protein%3B has potential N-terminal signal peptide. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2253;product=Possible secreted unknown protein;protein_id=CCP45034.1;transl_table=11
AL123456.3	EMBL	gene	2528520	2528975	.	-	.	ID=gene-Rv2254c;Name=Rv2254c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2254c
AL123456.3	EMBL	CDS	2528520	2528975	.	-	0	ID=cds-CCP45035.1;Parent=gene-Rv2254c;Dbxref=EnsemblGenomes-Gn:Rv2254c,EnsemblGenomes-Tr:CCP45035,GOA:O53528,InterPro:IPR001123,UniProtKB/TrEMBL:O53528,NCBI_GP:CCP45035.1;Name=CCP45035.1;Note=Rv2254c%2C (MTV022.04c)%2C len: 151 aa. Probable integral membrane protein.;gbkey=CDS;locus_tag=Rv2254c;product=Probable integral membrane protein;protein_id=CCP45035.1;transl_table=11
AL123456.3	EMBL	gene	2528980	2529174	.	-	.	ID=gene-Rv2255c;Name=Rv2255c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2255c
AL123456.3	EMBL	CDS	2528980	2529174	.	-	0	ID=cds-CCP45036.1;Parent=gene-Rv2255c;Dbxref=EnsemblGenomes-Gn:Rv2255c,EnsemblGenomes-Tr:CCP45036,UniProtKB/TrEMBL:O53529,NCBI_GP:CCP45036.1;Name=CCP45036.1;Note=Rv2255c%2C (MTV022.05c)%2C len: 64 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2255c;product=Hypothetical protein;protein_id=CCP45036.1;transl_table=11
AL123456.3	EMBL	gene	2529341	2529874	.	-	.	ID=gene-Rv2256c;Name=Rv2256c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2256c
AL123456.3	EMBL	CDS	2529341	2529874	.	-	0	ID=cds-CCP45037.1;Parent=gene-Rv2256c;Dbxref=EnsemblGenomes-Gn:Rv2256c,EnsemblGenomes-Tr:CCP45037,InterPro:IPR021491,UniProtKB/TrEMBL:O53530,NCBI_GP:CCP45037.1;Name=CCP45037.1;Note=Rv2256c%2C (MTV022.06c)%2C len: 177 aa. Conserved hypothetical protein%2C similar to Streptomyces glaucescens ORF5 (164 aa) and Streptomyces coelicolor hypothetical protein SC4A7.19c (164 aa%3B emb|CAB62723.1|AL133423). FASTA scores: sptr|Q54209|Q54209 FABD%2C FABH%2C FABC%2C FABB%2C and ORF5 (164 aa) opt: 504%2C E(): 3.9e-27%3B (44.4%25 identity in 162 aa overlap).;gbkey=CDS;locus_tag=Rv2256c;product=Conserved hypothetical protein;protein_id=CCP45037.1;transl_table=11
AL123456.3	EMBL	gene	2530004	2530822	.	-	.	ID=gene-Rv2257c;Name=Rv2257c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2257c
AL123456.3	EMBL	CDS	2530004	2530822	.	-	0	ID=cds-CCP45038.1;Parent=gene-Rv2257c;Dbxref=EnsemblGenomes-Gn:Rv2257c,EnsemblGenomes-Tr:CCP45038,GOA:O53531,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:O53531,NCBI_GP:CCP45038.1;Name=CCP45038.1;Note=Rv2257c%2C (MTV022.07c)%2C len: 272 aa. Conserved protein%2C similar to hypothetical protein SC4A7.08 from Streptomyces coelicolor (273 aa%3B 58%25 identity in 243 aa overlap). Also similar to several putative esterases and penicillin-binding proteins in M. tuberculosis e.g. Rv1923%2CRv1497%2C Rv2463%2C Rv3775%2C Rv1922%2C Rv1730c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2257c;product=Conserved protein;protein_id=CCP45038.1;transl_table=11
AL123456.3	EMBL	gene	2530836	2531897	.	-	.	ID=gene-Rv2258c;Name=Rv2258c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2258c
AL123456.3	EMBL	CDS	2530836	2531897	.	-	0	ID=cds-CCP45039.1;Parent=gene-Rv2258c;Dbxref=EnsemblGenomes-Gn:Rv2258c,EnsemblGenomes-Tr:CCP45039,GOA:O53532,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:O53532,NCBI_GP:CCP45039.1;Name=CCP45039.1;Note=Rv2258c%2C (MTV022.08c)%2C len: 353 aa. Possible transcriptional regulatory protein%2C similar to several hypothetical proteins from C. elegans. FASTA scores: sptr|O01593|O01593 coded for by C. elegans CDNA YK102 F (365 aa) opt: 577%2C E(): 6.4e-31%3B (30.5%25 identity in 341 aa overlap). Contains possible helix-turn helix motif at aa 47-68 (+3.65 SD);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2258c;product=Possible transcriptional regulatory protein;protein_id=CCP45039.1;transl_table=11
AL123456.3	EMBL	repeat_region	2531898	2531950	.	-	.	ID=id-AL123456.3:2531898..2531950;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2531951	2532003	.	-	.	ID=id-AL123456.3:2531951..2532003;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2532004	2532056	.	-	.	ID=id-AL123456.3:2532004..2532056;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2532057	2532109	.	-	.	ID=id-AL123456.3:2532057..2532109;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2532110	2532162	.	-	.	ID=id-AL123456.3:2532110..2532162;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2532163	2532212	.	-	.	ID=id-AL123456.3:2532163..2532212;Note=50 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	2532245	2533330	.	+	.	ID=gene-Rv2259;Name=mscR;gbkey=Gene;gene=mscR;gene_biotype=protein_coding;locus_tag=Rv2259
AL123456.3	EMBL	CDS	2532245	2533330	.	+	0	ID=cds-CCP45040.1;Parent=gene-Rv2259;Dbxref=EnsemblGenomes-Gn:Rv2259,EnsemblGenomes-Tr:CCP45040,GOA:O53533,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,InterPro:IPR017816,UniProtKB/TrEMBL:O53533,NCBI_GP:CCP45040.1;Name=CCP45040.1;Note=Rv2259%2C (MTV022.09)%2C len: 361 aa. MscR%2CS-nitrosomycothiol reductase (see Vogt et al.%2C 2003)%2Csimilar to several zinc-containing alcohol dehydrogenases especially from Amycolatopsis methanolica P80094 (360 aa)%2CFASTA scores: sp|P80094|FADH_AMYME NAD/mycothiol-dependent formaldehyde dehydrogenase (MD-FALDH) Length %3D 360%2C Expect %3D e-156%2C Identities %3D 268/358 (74%25). Also similar to Rv0162c%2C (MTCI28.02c%2C 35.0%25 identity in 371 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Note previously known as adhE2;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mscR;inference=protein motif:PROSITE:PS00059;locus_tag=Rv2259;product=S-nitrosomycothiol reductase MscR;protein_id=CCP45040.1;transl_table=11
AL123456.3	EMBL	gene	2533330	2533965	.	+	.	ID=gene-Rv2260;Name=Rv2260;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2260
AL123456.3	EMBL	CDS	2533330	2533965	.	+	0	ID=cds-CCP45041.1;Parent=gene-Rv2260;Dbxref=EnsemblGenomes-Gn:Rv2260,EnsemblGenomes-Tr:CCP45041,GOA:O53534,InterPro:IPR001279,UniProtKB/TrEMBL:O53534,NCBI_GP:CCP45041.1;Name=CCP45041.1;Note=Rv2260%2C (MTV022.10)%2C len: 211 aa. Conserved hypothetical protein%2C similar to hypothetical proteins Rv0634c%2C Rv1637c%2C Rv3677c%2C Rv2581c from Mycobacterium tuberculosis and to various hydrolases. FASTA scores: sptr|O06154|O06154 hypothetical 21.3 kDa protein (200 aa) opt: 355%2C E(): 4e- 15%3B (37.4%25 identity in 198 aa overlap).;gbkey=CDS;locus_tag=Rv2260;product=Conserved hypothetical protein;protein_id=CCP45041.1;transl_table=11
AL123456.3	EMBL	gene	2534042	2534464	.	-	.	ID=gene-Rv2261c;Name=Rv2261c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2261c
AL123456.3	EMBL	CDS	2534042	2534464	.	-	0	ID=cds-CCP45042.1;Parent=gene-Rv2261c;Dbxref=EnsemblGenomes-Gn:Rv2261c,EnsemblGenomes-Tr:CCP45042,GOA:I6XDW5,InterPro:IPR003010,UniProtKB/TrEMBL:I6XDW5,NCBI_GP:CCP45042.1;Name=CCP45042.1;Note=Rv2261c%2C (MTV022.11c)%2C len: 140 aa. Conserved hypothetical protein%2C with function unknown but some similarity to C-terminal end of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp. Note that next ORF shows similarity to N-terminal part of P74055 apolipoprotein N-acyltransferase from Escherichia coli (519 aa)%2C FASTA scores: opt: 142%2C E(): 0.007%2C (29.9%25 identity in 117 aa overlap)%2C suggesting possible frameshift. Sequence of clones from two sources has been checked but no error found.;gbkey=CDS;locus_tag=Rv2261c;product=Conserved hypothetical protein;protein_id=CCP45042.1;transl_table=11
AL123456.3	EMBL	gene	2534470	2535552	.	-	.	ID=gene-Rv2262c;Name=Rv2262c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2262c
AL123456.3	EMBL	CDS	2534470	2535552	.	-	0	ID=cds-CCP45043.1;Parent=gene-Rv2262c;Dbxref=EnsemblGenomes-Gn:Rv2262c,EnsemblGenomes-Tr:CCP45043,GOA:O53536,InterPro:IPR003010,InterPro:IPR004563,UniProtKB/TrEMBL:O53536,NCBI_GP:CCP45043.1;Name=CCP45043.1;Note=Rv2262c%2C (MTV022.12c)%2C len: 360 aa. Conserved hypothetical protein%2C with function unknown but some similarity to N-terminal 70%25 of P23930|P77703|LNT_ECOLI|cute|B0657 apolipoprotein N-acyltransferase from Escherichia coli strain K12 (512 aa)%2C FASTA scores: opt: 239%2C E(): 1.6e-07%2C (30.4%25 identity in 359 aa overlap). Note that neighboring ORF shows similarity to N -terminal part of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp.%2C suggesting possibility of frameshift. Sequence of clones from two sources has been checked but no error found. Appear to be two extra bases at position 1876970 compared to CDC1551 strain.;gbkey=CDS;locus_tag=Rv2262c;product=Conserved hypothetical protein;protein_id=CCP45043.1;transl_table=11
AL123456.3	EMBL	gene	2535641	2536594	.	+	.	ID=gene-Rv2263;Name=Rv2263;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2263
AL123456.3	EMBL	CDS	2535641	2536594	.	+	0	ID=cds-CCP45044.1;Parent=gene-Rv2263;Dbxref=EnsemblGenomes-Gn:Rv2263,EnsemblGenomes-Tr:CCP45044,GOA:O53537,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O53537,NCBI_GP:CCP45044.1;Name=CCP45044.1;Note=Rv2263%2C (MTV022.13)%2C len: 317 aa. Possible oxidoreductase%2C similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 probably an NADP-dependent oxidoreductase (297 aa) opt: 487%2C E(): 1.1e-23%3B (36.1%25 identity in 299 aa overlap). Also similar to Mycobacterium tuberculosis Rv0068%2C and Rv0439c.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2263;product=Possible oxidoreductase;protein_id=CCP45044.1;transl_table=11
AL123456.3	EMBL	gene	2536572	2538350	.	-	.	ID=gene-Rv2264c;Name=Rv2264c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2264c
AL123456.3	EMBL	CDS	2536572	2538350	.	-	0	ID=cds-CCP45045.1;Parent=gene-Rv2264c;Dbxref=EnsemblGenomes-Gn:Rv2264c,EnsemblGenomes-Tr:CCP45045,GOA:O53538,InterPro:IPR013126,UniProtKB/TrEMBL:O53538,NCBI_GP:CCP45045.1;Name=CCP45045.1;Note=Rv2264c%2C (MTV022.14c)%2C len: 592 aa. Conserved hypothetical Pro-rich protein%2C similar to hypothetical proteins Rv0312 (MTCY63.17%2C 620 aa and Rv0350) that has highly Pro-%2C Thr-rich C-terminus. Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. FASTA scores: Z96800|MTCY63_17 Mycobacterium tuberculosis cosmid (620 aa) opt: 1075%2C E(): 8.8e-24%3B (38.9%25 identity in 627 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;inference=protein motif:PROSITE:PS00343;locus_tag=Rv2264c;product=Conserved hypothetical proline rich protein;protein_id=CCP45045.1;transl_table=11
AL123456.3	EMBL	gene	2538700	2539929	.	+	.	ID=gene-Rv2265;Name=Rv2265;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2265
AL123456.3	EMBL	CDS	2538700	2539929	.	+	0	ID=cds-CCP45046.1;Parent=gene-Rv2265;Dbxref=EnsemblGenomes-Gn:Rv2265,EnsemblGenomes-Tr:CCP45046,GOA:P9WLG3,InterPro:IPR011701,InterPro:IPR016196,NCBI_GP:CCP45046.1;Name=CCP45046.1;Note=Rv2265%2C (MTCY339.45c)%2C len: 409 aa. Possible conserved integral membrane protein%2C with some similarity to others e.g. M. thermoauto. sp|O26855|O26855 conserved protein (383 aa)%2C FASTA score: opt: 898 z-score: 1023.5 E(): 0%3B 38.0%25 identity in 384 aa overlap%3B Q58713 hypothetical 44.1 kDa protein 1 317 (398 aa)%2C FASTA scores%2Copt: 305 E(): 1.2e-11%3B 22.8%25 identity in 382 aa overlap%3B also KGTP_ECOLI P17448 alpha-ketoglutarate permease (432 aa)%2C FASTA scores%2C opt: 156%2C E(): 0.006%2C (24.8%25 identity in 416 aa overlap);gbkey=CDS;locus_tag=Rv2265;product=Possible conserved integral membrane protein;protein_id=CCP45046.1;transl_table=11
AL123456.3	EMBL	gene	2540104	2541390	.	+	.	ID=gene-Rv2266;Name=cyp124;gbkey=Gene;gene=cyp124;gene_biotype=protein_coding;locus_tag=Rv2266
AL123456.3	EMBL	CDS	2540104	2541390	.	+	0	ID=cds-CCP45047.1;Parent=gene-Rv2266;Dbxref=EnsemblGenomes-Gn:Rv2266,EnsemblGenomes-Tr:CCP45047,GOA:P9WPP3,InterPro:IPR001128,InterPro:IPR002397,PDB:2WM4,PDB:2WM5,NCBI_GP:CCP45047.1;Name=CCP45047.1;Note=Rv2266%2C (MT2328%2C MTCY339.44c)%2C len: 428 aa. Probable cyp124%2C cytochrome P450%2C similar to e.g. G405543 cytochrome P450 (406 aa)%2C FASTA scores%2C opt: 763%2CE(): 0%2C (35.4%25 identity in 393 aa overlap)%2C similar to e.g. MTCY50.26%2C33.8%25 identity in 370 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp124;locus_tag=Rv2266;product=Probable cytochrome P450 124 Cyp124;protein_id=CCP45047.1;transl_table=11
AL123456.3	EMBL	gene	2541644	2542810	.	-	.	ID=gene-Rv2267c;Name=Rv2267c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2267c
AL123456.3	EMBL	CDS	2541644	2542810	.	-	0	ID=cds-CCP45048.1;Parent=gene-Rv2267c;Dbxref=EnsemblGenomes-Gn:Rv2267c,EnsemblGenomes-Tr:CCP45048,GOA:P9WLG1,InterPro:IPR027417,NCBI_GP:CCP45048.1;Name=CCP45048.1;Note=Rv2267c%2C (MTCY339.43)%2C len: 388 aa. Conserved hypothetical protein%3B some similarity to Mycobacterium tuberculosis Rv3529c%3B gp|Z82098|MTCY3C7_27 (384 aa) FASTA score: opt: 261%2C E(): 3.6e-10%3B 27.3%25 identity in 253 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2267c;product=Conserved hypothetical protein;protein_id=CCP45048.1;transl_table=11
AL123456.3	EMBL	gene	2542807	2544276	.	-	.	ID=gene-Rv2268c;Name=cyp128;gbkey=Gene;gene=cyp128;gene_biotype=protein_coding;locus_tag=Rv2268c
AL123456.3	EMBL	CDS	2542807	2544276	.	-	0	ID=cds-CCP45049.1;Parent=gene-Rv2268c;Dbxref=EnsemblGenomes-Gn:Rv2268c,EnsemblGenomes-Tr:CCP45049,GOA:P9WPN7,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,NCBI_GP:CCP45049.1;Name=CCP45049.1;Note=Rv2268c%2C (MT2330%2C MTCY339.42)%2C len: 489 aa. Probable cyp128%2C cytochrome P450%2C similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa)%2C FASTA scores%2C opt: 620%2C E(): 8.3e-33%2C(31.8%25 identity in 406 aa overlap)%3B contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature%2Csimilar to MTCY50.26%2C 32.7%25 identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=cyp128;inference=protein motif:PROSITE:PS00086;locus_tag=Rv2268c;product=Probable cytochrome P450 128 Cyp128;protein_id=CCP45049.1;transl_table=11
AL123456.3	EMBL	gene	2544289	2544621	.	-	.	ID=gene-Rv2269c;Name=Rv2269c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2269c
AL123456.3	EMBL	CDS	2544289	2544621	.	-	0	ID=cds-CCP45050.1;Parent=gene-Rv2269c;Dbxref=EnsemblGenomes-Gn:Rv2269c,EnsemblGenomes-Tr:CCP45050,GOA:P9WLF9,NCBI_GP:CCP45050.1;Name=CCP45050.1;Note=Rv2269c%2C (MTCY339.41)%2C len: 110 aa. Unknown protein%3B questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2269c;product=Hypothetical protein;protein_id=CCP45050.1;transl_table=11
AL123456.3	EMBL	gene	2544698	2545225	.	+	.	ID=gene-Rv2270;Name=lppN;gbkey=Gene;gene=lppN;gene_biotype=protein_coding;locus_tag=Rv2270
AL123456.3	EMBL	CDS	2544698	2545225	.	+	0	ID=cds-CCP45051.1;Parent=gene-Rv2270;Dbxref=EnsemblGenomes-Gn:Rv2270,EnsemblGenomes-Tr:CCP45051,GOA:P9WK73,NCBI_GP:CCP45051.1;Name=CCP45051.1;Note=Rv2270%2C (MTCY339.40c)%2C len: 175 aa. Probable lppN%2Clipoprotein%3B has appropriately positioned prokaryotic membrane lipoprotein attachment site PS00013.;gbkey=CDS;gene=lppN;locus_tag=Rv2270;product=Probable lipoprotein LppN;protein_id=CCP45051.1;transl_table=11
AL123456.3	EMBL	gene	2545332	2545631	.	+	.	ID=gene-Rv2271;Name=Rv2271;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2271
AL123456.3	EMBL	CDS	2545332	2545631	.	+	0	ID=cds-CCP45052.1;Parent=gene-Rv2271;Dbxref=EnsemblGenomes-Gn:Rv2271,EnsemblGenomes-Tr:CCP45052,InterPro:IPR024248,NCBI_GP:CCP45052.1;Name=CCP45052.1;Note=Rv2271%2C (MTCY339.39c)%2C len: 99 aa. Conserved hypothetical protein%3B some similarity to hypothetical protein AAK01340.1|AF265275_3 (AF265275) from uncultured organism Pu8 (104 aa) E%3D 4e-10%2C (34%25 identity in 91 aa overlap);gbkey=CDS;locus_tag=Rv2271;product=Conserved hypothetical protein;protein_id=CCP45052.1;transl_table=11
AL123456.3	EMBL	gene	2545737	2546105	.	+	.	ID=gene-Rv2272;Name=Rv2272;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2272
AL123456.3	EMBL	CDS	2545737	2546105	.	+	0	ID=cds-CCP45053.1;Parent=gene-Rv2272;Dbxref=EnsemblGenomes-Gn:Rv2272,EnsemblGenomes-Tr:CCP45053,GOA:P9WLF5,InterPro:IPR003807,NCBI_GP:CCP45053.1;Name=CCP45053.1;Note=Rv2272%2C (MTCY339.38c)%2C len: 122 aa. Probable conserved transmembrane protein%2C similar to YIDH_ECOLI P31445 hypothetical 12.8 kDa protein (115 aa)%2C FASTA scores%2C opt: 291%2C E(): 2.9e-14%2C (45.6%25 identity in 103 aa overlap)%2C similar to MTCY339.37c%2C (35.0%25 identity in 100 aa overlap).;gbkey=CDS;locus_tag=Rv2272;product=Probable conserved transmembrane protein;protein_id=CCP45053.1;transl_table=11
AL123456.3	EMBL	gene	2546102	2546431	.	+	.	ID=gene-Rv2273;Name=Rv2273;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2273
AL123456.3	EMBL	CDS	2546102	2546431	.	+	0	ID=cds-CCP45054.1;Parent=gene-Rv2273;Dbxref=EnsemblGenomes-Gn:Rv2273,EnsemblGenomes-Tr:CCP45054,GOA:P9WLF3,InterPro:IPR003807,InterPro:IPR020264,NCBI_GP:CCP45054.1;Name=CCP45054.1;Note=Rv2273%2C (MTCY339.37c)%2C len: 109 aa. Probable conserved transmembrane protein%2C similar to Rv2272 (MTCY339.38c)%2C (35.0%25 identity in 100 aa overlap).;gbkey=CDS;locus_tag=Rv2273;product=Probable conserved transmembrane protein;protein_id=CCP45054.1;transl_table=11
AL123456.3	EMBL	gene	2546488	2546805	.	-	.	ID=gene-Rv2274c;Name=mazF8;gbkey=Gene;gene=mazF8;gene_biotype=protein_coding;locus_tag=Rv2274c
AL123456.3	EMBL	CDS	2546488	2546805	.	-	0	ID=cds-CCP45055.1;Parent=gene-Rv2274c;Dbxref=EnsemblGenomes-Gn:Rv2274c,EnsemblGenomes-Tr:CCP45055,GOA:P9WIH7,NCBI_GP:CCP45055.1;Name=CCP45055.1;Note=Rv2274c%2C (MTCY339.36)%2C len: 105 aa. Possible mazF8%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2274A (See Pandey and Gerdes%2C 2005). Questionable ORF.;gbkey=CDS;gene=mazF8;locus_tag=Rv2274c;product=Possible toxin MazF8;protein_id=CCP45055.1;transl_table=11
AL123456.3	EMBL	gene	2546839	2547087	.	-	.	ID=gene-Rv2274A;Name=mazE8;gbkey=Gene;gene=mazE8;gene_biotype=protein_coding;locus_tag=Rv2274A
AL123456.3	EMBL	CDS	2546839	2547087	.	-	0	ID=cds-CCP45056.1;Parent=gene-Rv2274A;Dbxref=EnsemblGenomes-Gn:Rv2274A,EnsemblGenomes-Tr:CCP45056,NCBI_GP:CCP45056.1;Name=CCP45056.1;Note=Rv2274A%2C len: 82 aa. Possible mazE8%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv2274c (See Pandey and Gerdes%2C 2005).;gbkey=CDS;gene=mazE8;locus_tag=Rv2274A;product=Possible antitoxin MazE8;protein_id=CCP45056.1;transl_table=11
AL123456.3	EMBL	gene	2546883	2547752	.	+	.	ID=gene-Rv2275;Name=Rv2275;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2275
AL123456.3	EMBL	CDS	2546883	2547752	.	+	0	ID=cds-CCP45057.1;Parent=gene-Rv2275;Dbxref=EnsemblGenomes-Gn:Rv2275,EnsemblGenomes-Tr:CCP45057,GOA:P9WPF9,PDB:2X9Q,NCBI_GP:CCP45057.1;Name=CCP45057.1;Note=Rv2275%2C (MTCY339.35c)%2C len: 289 aa. Conserved hypothetical protein. Some similarity to Bacillus subtilis sp|O34351|O34351 YVMC (248 aa)%2C FASTA score: opt: 280%2C E(): 2.7e -11%3B 28.2%25 identity in 227 aa overlap;gbkey=CDS;locus_tag=Rv2275;product=Conserved hypothetical protein;protein_id=CCP45057.1;transl_table=11
AL123456.3	EMBL	gene	2547749	2548939	.	+	.	ID=gene-Rv2276;Name=cyp121;gbkey=Gene;gene=cyp121;gene_biotype=protein_coding;locus_tag=Rv2276
AL123456.3	EMBL	CDS	2547749	2548939	.	+	0	ID=cds-CCP45058.1;Parent=gene-Rv2276;Dbxref=EnsemblGenomes-Gn:Rv2276,EnsemblGenomes-Tr:CCP45058,GOA:P9WPP7,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,PDB:1N40,PDB:1N4G,PDB:2IJ5,PDB:2IJ7,PDB:3CXV,PDB:3CXX,PDB:3CXY,PDB:3CXZ,PDB:3CY0,PDB:3CY1,PDB:3G5F,PDB:3G5H,PDB:4G1X,PDB:4G2G,PDB:4G44,PDB:4G45,PDB:4G46,PDB:4G47,PDB:4G48,PDB:4ICT,PDB:4IPS,PDB:4IPW,PDB:4IQ7,PDB:4IQ9,NCBI_GP:CCP45058.1;Name=CCP45058.1;Note=Rv2276%2C (MT2336%2C MTCY339.34c)%2C len: 396 aa. Cyp121%2Ccytochrome P450 (see citation below)%2C similar to e.g. G303644 (397 aa) opt: 675%2C z-score: 776.4%2C E(): 2.7e-36%2C(33.7%25 identity in 407 aa overlap)%3B contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature%2Csimilar to MTCY339.42%2C 29.2%25 identity in 298 aa overlap.;gbkey=CDS;gene=cyp121;inference=protein motif:PROSITE:PS00086;locus_tag=Rv2276;product=Cytochrome P450 121 Cyp121;protein_id=CCP45058.1;transl_table=11
AL123456.3	EMBL	gene	2549124	2550029	.	-	.	ID=gene-Rv2277c;Name=Rv2277c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2277c
AL123456.3	EMBL	CDS	2549124	2550029	.	-	0	ID=cds-CCP45059.1;Parent=gene-Rv2277c;Dbxref=EnsemblGenomes-Gn:Rv2277c,EnsemblGenomes-Tr:CCP45059,GOA:P9WLF1,InterPro:IPR004129,InterPro:IPR017946,NCBI_GP:CCP45059.1;Name=CCP45059.1;Note=Rv2277c%2C (MTCY339.33)%2C len: 301 aa. Possible glycerolphosphodiesterase%2C similar to e.g. UGPQ_ECOLI P10908 glycerophosphoryldiester phosphodiesterase (cytosolic) (247 aa)%2C FASTA scores%2C opt: 149%2C E(): 0.0061%2C(27.2%25 identity in 195 aa overlap). Start of protein uncertain%2C encoded by neighbouring IS6110 as given%2C is intact in Mycobacterium tuberculosis CDC1551;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2277c;product=Possible glycerolphosphodiesterase;protein_id=CCP45059.1;transl_table=11
AL123456.3	EMBL	repeat_region	2550011	2550013	.	+	.	ID=id-AL123456.3:2550011..2550013;Note=3 bp direct repeat%2C ccg%2C flanking IS6110;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	2550014	2551368	.	+	.	ID=id-AL123456.3:2550014..2551368;Note=IS6110-7%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-7
AL123456.3	EMBL	repeat_region	2550014	2550041	.	+	.	ID=id-AL123456.3:2550014..2550041;Note=28 bp inverted repeat at the left end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	2550065	2550391	.	+	.	ID=gene-Rv2278;Name=Rv2278;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2278
AL123456.3	EMBL	CDS	2550065	2550391	.	+	0	ID=cds-CCP45060.1;Parent=gene-Rv2278;Dbxref=EnsemblGenomes-Gn:Rv2278,EnsemblGenomes-Tr:CCP45060,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP45060.1;Name=CCP45060.1;Note=Rv2278%2C (MTCY339.32c)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2278 and Rv2279%2Cthe sequence UUUUAAAG (directly upstream of Rv2279) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv2278;product=Putative transposase for insertion sequence element IS6110 (fragment);protein_id=CCP45060.1;transl_table=11
AL123456.3	EMBL	gene	2550340	2551326	.	+	.	ID=gene-Rv2279;Name=Rv2279;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2279;partial=true;start_range=.,2550340
AL123456.3	EMBL	CDS	2550340	2551326	.	+	0	ID=cds-CCP45061.1;Parent=gene-Rv2279;Dbxref=EnsemblGenomes-Gn:Rv2279,EnsemblGenomes-Tr:CCP45061,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP45061.1;Name=CCP45061.1;Note=Rv2279%2C (MTCY339.31c)%2C len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2278 and Rv2279%2C the sequence UUUUAAAG (directly upstream of Rv2279) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 16 aa).;gbkey=CDS;locus_tag=Rv2279;partial=true;product=Probable transposase;protein_id=CCP45061.1;start_range=.,2550340;transl_table=11
AL123456.3	EMBL	repeat_region	2551341	2551368	.	+	.	ID=id-AL123456.3:2551341..2551368;Note=28 bp inverted repeat at the right end of IS6110%2CGAGTCTCCGGACTCACCGGGGCGGTTCA;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2551369	2551371	.	+	.	ID=id-AL123456.3:2551369..2551371;Note=3 bp direct repeat%2C ccg%2C flanking IS6110;gbkey=repeat_region
AL123456.3	EMBL	gene	2551560	2552939	.	+	.	ID=gene-Rv2280;Name=Rv2280;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2280
AL123456.3	EMBL	CDS	2551560	2552939	.	+	0	ID=cds-CCP45062.1;Parent=gene-Rv2280;Dbxref=EnsemblGenomes-Gn:Rv2280,EnsemblGenomes-Tr:CCP45062,GOA:P9WIT1,InterPro:IPR004113,InterPro:IPR006094,InterPro:IPR016164,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,InterPro:IPR016171,NCBI_GP:CCP45062.1;Name=CCP45062.1;Note=Rv2280%2C (MTCY339.30c)%2C len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa)%2C FASTA scores%2C opt: 645%2CE(): 1.3e-31%2C (28.0%25 identity in 478 aa overlap)%2C similar to MTCY50.25%2C 36.5%25 identity in 447 aa overlap;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2280;product=Probable dehydrogenase;protein_id=CCP45062.1;transl_table=11
AL123456.3	EMBL	gene	2553173	2554831	.	+	.	ID=gene-Rv2281;Name=pitB;gbkey=Gene;gene=pitB;gene_biotype=protein_coding;locus_tag=Rv2281
AL123456.3	EMBL	CDS	2553173	2554831	.	+	0	ID=cds-CCP45063.1;Parent=gene-Rv2281;Dbxref=EnsemblGenomes-Gn:Rv2281,EnsemblGenomes-Tr:CCP45063,GOA:P9WIA5,InterPro:IPR001204,NCBI_GP:CCP45063.1;Name=CCP45063.1;Note=Rv2281%2C (MTCY339.29c)%2C len: 552 aa. Putative pitB%2Cphosphate-transport permease%2C integral membrane protein%2Csimilar to YG04_HAEIN P45268 putative phosphate permease hi1604 (420 aa). FASTA scores%2C opt: 484%2C E(): 5e-23%2C (33.5%25 identity in 498 aa overlap) also to G399598 amphotropic murine retrovirus receptor (656 aa) FASTA scores%2C opt: 453%2CE(): 5.8e-21%2C (26.8%25 identity in 645 aa overlap). Also similar to Rv0545c|pitA from M. tuberculosis. Belongs to the pit subfamily.;gbkey=CDS;gene=pitB;locus_tag=Rv2281;product=Putative phosphate-transport permease PitB;protein_id=CCP45063.1;transl_table=11
AL123456.3	EMBL	gene	2554938	2555876	.	-	.	ID=gene-Rv2282c;Name=Rv2282c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2282c
AL123456.3	EMBL	CDS	2554938	2555876	.	-	0	ID=cds-CCP45064.1;Parent=gene-Rv2282c;Dbxref=EnsemblGenomes-Gn:Rv2282c,EnsemblGenomes-Tr:CCP45064,GOA:P9WMF3,InterPro:IPR000847,InterPro:IPR005119,InterPro:IPR011991,NCBI_GP:CCP45064.1;Name=CCP45064.1;Note=Rv2282c%2C (MTCY339.28)%2C len: 312 aa. Probable transcriptional regulator%2C lysR family%2C similar to others e.g. YC30_CYAPA|P48271 hypothetical transcriptional regulator YCF30 (324 aa)%2C FASTA scores: opt: 292%2C E(): 4e-12%2C (27.6%25 identity in 286 aa overlap)%3B etc. Also similar to Rv0377|MTCY39.34 from Mycobacterium tuberculosis%2C FASTA score: (25.4%25 identity in 268 aa overlap). Contains PS00044 Bacterial regulatory proteins%2ClysR family signature%2C and contains helix-turn-helix motif at aa 24 -45 (+4.93 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv2282c;product=Probable transcription regulator (LysR family);protein_id=CCP45064.1;transl_table=11
AL123456.3	EMBL	gene	2555941	2556135	.	+	.	ID=gene-Rv2283;Name=Rv2283;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2283
AL123456.3	EMBL	CDS	2555941	2556135	.	+	0	ID=cds-CCP45065.1;Parent=gene-Rv2283;Dbxref=EnsemblGenomes-Gn:Rv2283,EnsemblGenomes-Tr:CCP45065,GOA:P9WLE9,NCBI_GP:CCP45065.1;Name=CCP45065.1;Note=Rv2283%2C (MTCY339.27c)%2C len: 64 aa. Unknown protein%3B questionable ORF.;gbkey=CDS;locus_tag=Rv2283;product=Hypothetical protein;protein_id=CCP45065.1;transl_table=11
AL123456.3	EMBL	gene	2556145	2557440	.	+	.	ID=gene-Rv2284;Name=lipM;gbkey=Gene;gene=lipM;gene_biotype=protein_coding;locus_tag=Rv2284
AL123456.3	EMBL	CDS	2556145	2557440	.	+	0	ID=cds-CCP45066.1;Parent=gene-Rv2284;Dbxref=EnsemblGenomes-Gn:Rv2284,EnsemblGenomes-Tr:CCP45066,GOA:Q50681,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:Q50681,NCBI_GP:CCP45066.1;Name=CCP45066.1;Note=Rv2284%2C (MTCY339.26c)%2C len: 431 aa. Probable lipM%2Cesterase%2C similar to others e.g. gp|Z95844|MTCY493_28 from Mycobacterium tuberculosis cosmid (420 aa)%2C FASTA scores: opt: 1266%2C E(): 0%2C (50.1%25 identity in 411 aa overlap). Some similarity to G537514 arylacetamide deacetylase (399 aa)%2CFASTA scores: opt: 190%2C E(): 5.9e-05%2C (30.4%25 identity in 138 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipM;locus_tag=Rv2284;product=Probable esterase LipM;protein_id=CCP45066.1;transl_table=11
AL123456.3	EMBL	gene	2557473	2558810	.	+	.	ID=gene-Rv2285;Name=Rv2285;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2285
AL123456.3	EMBL	CDS	2557473	2558810	.	+	0	ID=cds-CCP45067.1;Parent=gene-Rv2285;Dbxref=EnsemblGenomes-Gn:Rv2285,EnsemblGenomes-Tr:CCP45067,GOA:P9WKB5,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP45067.1;Name=CCP45067.1;Note=Rv2285%2C (MTCY339.25c)%2C len: 445 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C member of Mycobacterium tuberculosis 15-membered protein family including Rv3740c%2C Rv3734c%2C Rv1425%2C Rv1760%2C Rv0895%2CRv3480c. FASTA scores: gp|Z95844|MTCY493_29 Mycobacterium tuberculosis cosmid (459 aa) opt: 640%2C E(): 0%3B 33.4%25 identity in 470 aa overlap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2285;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP45067.1;transl_table=11
AL123456.3	EMBL	gene	2558877	2559569	.	-	.	ID=gene-Rv2286c;Name=Rv2286c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2286c
AL123456.3	EMBL	CDS	2558877	2559569	.	-	0	ID=cds-CCP45068.1;Parent=gene-Rv2286c;Dbxref=EnsemblGenomes-Gn:Rv2286c,EnsemblGenomes-Tr:CCP45068,GOA:P9WLE7,InterPro:IPR001853,InterPro:IPR012336,NCBI_GP:CCP45068.1;Name=CCP45068.1;Note=Rv2286c%2C (MTCY339.24)%2C len: 230 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein%2C Rv2466c%2C AL021246|MTV008_22 (207 aa). FASTA score: opt: 324%2C E(): 8.9e-15%3B 30.4%25 identity in 194 aa overlap;gbkey=CDS;locus_tag=Rv2286c;product=Conserved hypothetical protein;protein_id=CCP45068.1;transl_table=11
AL123456.3	EMBL	gene	2559703	2561331	.	+	.	ID=gene-Rv2287;Name=yjcE;gbkey=Gene;gene=yjcE;gene_biotype=protein_coding;locus_tag=Rv2287
AL123456.3	EMBL	CDS	2559703	2561331	.	+	0	ID=cds-CCP45069.1;Parent=gene-Rv2287;Dbxref=EnsemblGenomes-Gn:Rv2287,EnsemblGenomes-Tr:CCP45069,GOA:P9WJI3,InterPro:IPR004705,InterPro:IPR006153,InterPro:IPR018422,NCBI_GP:CCP45069.1;Name=CCP45069.1;Note=Rv2287%2C (MTCY339.23c)%2C len: 542 aa. Probable yjcE%2Cconserved integral membrane transport protein%2C similar to eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065 Putative Na(+)/H(+) exchanger from Escherichia coli (549 aa)%2C FASTA scores: opt: 436%2C E(): 5.6e-21%2C (29.4%25 identity in 555 aa overlap)%3B etc. Seems to belong to CPA1 family (NA(+)/H(+) exchanger family).;gbkey=CDS;gene=yjcE;locus_tag=Rv2287;product=Probable conserved integral membrane transport protein YjcE;protein_id=CCP45069.1;transl_table=11
AL123456.3	EMBL	gene	2561328	2561705	.	+	.	ID=gene-Rv2288;Name=Rv2288;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2288
AL123456.3	EMBL	CDS	2561328	2561705	.	+	0	ID=cds-CCP45070.1;Parent=gene-Rv2288;Dbxref=EnsemblGenomes-Gn:Rv2288,EnsemblGenomes-Tr:CCP45070,GOA:P9WLE5,NCBI_GP:CCP45070.1;Name=CCP45070.1;Note=Rv2288%2C (MTCY339.22c)%2C len: 125 aa. Unknown hypothetical protein;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2288;product=Hypothetical protein;protein_id=CCP45070.1;transl_table=11
AL123456.3	EMBL	gene	2561675	2562457	.	+	.	ID=gene-Rv2289;Name=cdh;gbkey=Gene;gene=cdh;gene_biotype=protein_coding;locus_tag=Rv2289
AL123456.3	EMBL	CDS	2561675	2562457	.	+	0	ID=cds-CCP45071.1;Parent=gene-Rv2289;Dbxref=EnsemblGenomes-Gn:Rv2289,EnsemblGenomes-Tr:CCP45071,GOA:P9WPG9,InterPro:IPR003763,InterPro:IPR011146,NCBI_GP:CCP45071.1;Name=CCP45071.1;Note=Rv2289%2C (MTCY339.21c)%2C len: 260 aa. Probable cdh%2CCDP-diacylglycerol pyrophosphatase%2C similar to CDH_SALTY|P26219 cdp-diacylglycerol pyrophosphatase (251 aa)%2C FASTA scores: opt: 395%2C E(): 5.9e-20%2C (33.5%25 identity in 221 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cdh;locus_tag=Rv2289;product=Probable CDP-diacylglycerol pyrophosphatase Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase);protein_id=CCP45071.1;transl_table=11
AL123456.3	EMBL	gene	2562599	2563114	.	+	.	ID=gene-Rv2290;Name=lppO;gbkey=Gene;gene=lppO;gene_biotype=protein_coding;locus_tag=Rv2290
AL123456.3	EMBL	CDS	2562599	2563114	.	+	0	ID=cds-CCP45072.1;Parent=gene-Rv2290;Dbxref=EnsemblGenomes-Gn:Rv2290,EnsemblGenomes-Tr:CCP45072,GOA:P9WK71,NCBI_GP:CCP45072.1;Name=CCP45072.1;Note=Rv2290%2C (MTCY339.20c)%2C len: 171 aa. Probable lppO%2Cconserved lipoprotein%2C similar to Rv3763%2C 19KD_MYCTU P11572 19 kDa lipoprotein antigen precursor (159 aa) FASTA scores%2Copt: 119%2C E (): 1.3%2C (25.6%25 identity in 164 aa overlap). Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppO;locus_tag=Rv2290;product=Probable conserved lipoprotein LppO;protein_id=CCP45072.1;transl_table=11
AL123456.3	EMBL	gene	2563174	2564028	.	+	.	ID=gene-Rv2291;Name=sseB;gbkey=Gene;gene=sseB;gene_biotype=protein_coding;locus_tag=Rv2291
AL123456.3	EMBL	CDS	2563174	2564028	.	+	0	ID=cds-CCP45073.1;Parent=gene-Rv2291;Dbxref=EnsemblGenomes-Gn:Rv2291,EnsemblGenomes-Tr:CCP45073,GOA:P9WHF5,InterPro:IPR001307,InterPro:IPR001763,NCBI_GP:CCP45073.1;Name=CCP45073.1;Note=Rv2291%2C (MTCY339.19c)%2C len: 284 aa. Probable sseB%2Cthiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765%2C E(): 0%3B Smith-Waterman score: 765%3B 46.9%25 identity in 286 aa overlap%2C similar to THTR_ECOLI P31142 putative thiosulfate sulfurtransferase (280 aa)%2C FASTA scores%2C opt: 478%2C E(): 1e-23%2C (35.1%25 identity in 265 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sseB;locus_tag=Rv2291;product=Probable thiosulfate sulfurtransferase SseB;protein_id=CCP45073.1;transl_table=11
AL123456.3	EMBL	gene	2564029	2564253	.	-	.	ID=gene-Rv2292c;Name=Rv2292c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2292c
AL123456.3	EMBL	CDS	2564029	2564253	.	-	0	ID=cds-CCP45074.1;Parent=gene-Rv2292c;Dbxref=EnsemblGenomes-Gn:Rv2292c,EnsemblGenomes-Tr:CCP45074,GOA:P9WLE3,InterPro:IPR000845,NCBI_GP:CCP45074.1;Name=CCP45074.1;Note=Rv2292c%2C (MTCY339.18)%2C len: 74 aa. Unknown hypothetical protein;gbkey=CDS;locus_tag=Rv2292c;product=Hypothetical protein;protein_id=CCP45074.1;transl_table=11
AL123456.3	EMBL	gene	2564292	2565032	.	-	.	ID=gene-Rv2293c;Name=Rv2293c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2293c
AL123456.3	EMBL	CDS	2564292	2565032	.	-	0	ID=cds-CCP45075.1;Parent=gene-Rv2293c;Dbxref=EnsemblGenomes-Gn:Rv2293c,EnsemblGenomes-Tr:CCP45075,GOA:P9WLE1,InterPro:IPR000845,NCBI_GP:CCP45075.1;Name=CCP45075.1;Note=Rv2293c%2C (MTCY339.17)%2C len: 246 aa. Conserved hypothetical protein%3B some similarity to hypothetical protein (299 aa) AAK24237.1| (AE005897) belonging to phosphorylase family [Caulobacter crescentus] (33%25 identity in 131 aa overlap). Possible lipoprotein: signal peptide at N-terminus;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2293c;product=Conserved hypothetical protein;protein_id=CCP45075.1;transl_table=11
AL123456.3	EMBL	gene	2565327	2566550	.	+	.	ID=gene-Rv2294;Name=Rv2294;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2294
AL123456.3	EMBL	CDS	2565327	2566550	.	+	0	ID=cds-CCP45076.1;Parent=gene-Rv2294;Dbxref=EnsemblGenomes-Gn:Rv2294,EnsemblGenomes-Tr:CCP45076,GOA:P9WQ83,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP45076.1;Name=CCP45076.1;Note=Rv2294%2C (MTCY339.16c)%2C len: 407 aa. Probable aminotransferase%2C similar to others in M. tuberculosis e.g. MTV030_19%2C also similar to PATB_BACSU|Q08432 putative aminotransferase b from Bacillus subtilis (387 aa)%2C FASTA scores: opt: 563%2C E(): 2.8e-29%2C (31.4%25 identity in 408 aa overlap)%3B and to MALY_ECOLI|P23256 maly protein from Escherichia coli (390 aa)%2C FASTA scores: opt: 530%2C E(): 3.6e-27%2C (31.3%25 identity in 384 aa overlap). Belongs to class-II of pyridoxal-phosphate-dependent aminotransferases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2294;product=Probable aminotransferase;protein_id=CCP45076.1;transl_table=11
AL123456.3	EMBL	gene	2566772	2567410	.	+	.	ID=gene-Rv2295;Name=Rv2295;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2295
AL123456.3	EMBL	CDS	2566772	2567410	.	+	0	ID=cds-CCP45077.1;Parent=gene-Rv2295;Dbxref=EnsemblGenomes-Gn:Rv2295,EnsemblGenomes-Tr:CCP45077,GOA:P9WFL7,InterPro:IPR005363,NCBI_GP:CCP45077.1;Name=CCP45077.1;Note=Rv2295%2C (MTCY339.15c)%2C len: 212 aa. Conserved hypothetical protein%2C cysteine-rich protein%2C similar to YIEJ_ECOLI P31469 hypothetical 22.5 kDa protein in tnab-bglb intergenic region (195 aa)%2C opt: 270%2C E(): 3.4e-11%2C (36.4%25 identity in 198 aa overlap). Alternative start suggested by similarity 26 codons further downstream;gbkey=CDS;locus_tag=Rv2295;product=Conserved hypothetical protein;protein_id=CCP45077.1;transl_table=11
AL123456.3	EMBL	gene	2567504	2568406	.	+	.	ID=gene-Rv2296;Name=Rv2296;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2296
AL123456.3	EMBL	CDS	2567504	2568406	.	+	0	ID=cds-CCP45078.1;Parent=gene-Rv2296;Dbxref=EnsemblGenomes-Gn:Rv2296,EnsemblGenomes-Tr:CCP45078,GOA:P9WMS3,InterPro:IPR000073,InterPro:IPR000639,InterPro:IPR023489,InterPro:IPR029058,NCBI_GP:CCP45078.1;Name=CCP45078.1;Note=Rv2296%2C (MTCY339.14c)%2C len: 300 aa. Probable haloalkane dehalogenase%2C similar to e.g. HALO_XANAU P22643%2Chaloalkane dehalogenase%2C (310 aa)%2C opt: 510 z-score: 577.7 E(): 3.1e-25 (39.0%25 identity in 315 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2296;product=Probable haloalkane dehalogenase;protein_id=CCP45078.1;transl_table=11
AL123456.3	EMBL	gene	2568438	2568890	.	+	.	ID=gene-Rv2297;Name=Rv2297;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2297
AL123456.3	EMBL	CDS	2568438	2568890	.	+	0	ID=cds-CCP45079.1;Parent=gene-Rv2297;Dbxref=EnsemblGenomes-Gn:Rv2297,EnsemblGenomes-Tr:CCP45079,GOA:P9WLD9,NCBI_GP:CCP45079.1;Name=CCP45079.1;Note=Rv2297%2C (MTCY339.13c)%2C len: 150 aa. Unknown protein%3B contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00343;locus_tag=Rv2297;product=Unknown protein;protein_id=CCP45079.1;transl_table=11
AL123456.3	EMBL	gene	2569082	2570053	.	+	.	ID=gene-Rv2298;Name=Rv2298;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2298
AL123456.3	EMBL	CDS	2569082	2570053	.	+	0	ID=cds-CCP45080.1;Parent=gene-Rv2298;Dbxref=EnsemblGenomes-Gn:Rv2298,EnsemblGenomes-Tr:CCP45080,GOA:P9WQA7,InterPro:IPR001395,InterPro:IPR023210,NCBI_GP:CCP45080.1;Name=CCP45080.1;Note=Rv2298%2C (MTCY339.12c)%2C len: 323 aa. Conserved protein. Similar to SLR0545 Synechocystis sp%2C Q55493 hypothetical 34.6 kDa protein (314 aa)%2C FASTA scores%2C opt: 427%2C E(): 1.7e-20%2C (39.3%25 identity in 303 aa overlap) and to YZAE_BACSU P46905 hypothetical protein in natb 3'region (268 aa) FASTA scores%2C opt: 370%2C E(): 6.1e-17%2C (31.4%25 identity in 264 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2298;product=Conserved protein;protein_id=CCP45080.1;transl_table=11
AL123456.3	EMBL	gene	2570059	2572002	.	-	.	ID=gene-Rv2299c;Name=htpG;gbkey=Gene;gene=htpG;gene_biotype=protein_coding;locus_tag=Rv2299c
AL123456.3	EMBL	CDS	2570059	2572002	.	-	0	ID=cds-CCP45081.1;Parent=gene-Rv2299c;Dbxref=EnsemblGenomes-Gn:Rv2299c,EnsemblGenomes-Tr:CCP45081,GOA:P9WMJ7,InterPro:IPR001404,InterPro:IPR003594,InterPro:IPR019805,InterPro:IPR020568,InterPro:IPR020575,NCBI_GP:CCP45081.1;Name=CCP45081.1;Note=Rv2299c%2C (MTCY339.11)%2C len: 647 aa. HtpG%2C probable chaperone%2C heat shock protein 90 family. Similar to HTPG_BACSU|P46208 heat shock protein htpG homologue from Bacillus subtilis (626 aa)%2C FASTA scores: opt: 1551%2C E(): 0%2C (39.6%25 identity in 631 aa overlap). Contains possible helix-turn-helix motif at aa 519-540 (+3.77 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=htpG;locus_tag=Rv2299c;product=Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G);protein_id=CCP45081.1;transl_table=11
AL123456.3	EMBL	gene	2572076	2573008	.	-	.	ID=gene-Rv2300c;Name=Rv2300c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2300c
AL123456.3	EMBL	CDS	2572076	2573008	.	-	0	ID=cds-CCP45082.1;Parent=gene-Rv2300c;Dbxref=EnsemblGenomes-Gn:Rv2300c,EnsemblGenomes-Tr:CCP45082,GOA:P9WLD7,InterPro:IPR001279,NCBI_GP:CCP45082.1;Name=CCP45082.1;Note=Rv2300c%2C (MTCY339.09)%2C len: 310 aa (start uncertain). Conserved protein%2C similar to others e.g. Q9RXY2|DR0172 conserved hypothetical protein from Deinococcus radiodurans (271 aa)%2C FASTA scores: opt: 306%2CE(): 1.3e-12%2C (34.6%25 identity in 229 aa overlap)%3B Q9HZH1|PA3037 hypothetical protein from Pseudomonas aeruginosa (288 aa)%2C FASTA scores: opt: 248%2C E(): 7.9e-09%2C(31.5%25 identity in 238 aa overlap)%3B Q9PDL8|XF1361 hypothetical protein from Xylella fastidiosa (279 aa)%2CFASTA scores: opt: 236%2C E(): 4.6e-08%2C (29.7%25 identity in 249 aa overlap)%3B U70053|XCU70053_3 GumP protein from Xanthomonas campestris (282 aa)%2C FASTA scores: opt: 222%2CE(): 3.7e-07%2C (30.1%25 identity in 248 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2300c;product=Conserved protein;protein_id=CCP45082.1;transl_table=11
AL123456.3	EMBL	gene	2573015	2573707	.	+	.	ID=gene-Rv2301;Name=cut2;gbkey=Gene;gene=cut2;gene_biotype=protein_coding;gene_synonym=cfp25,clp2,culp2;locus_tag=Rv2301
AL123456.3	EMBL	CDS	2573015	2573707	.	+	0	ID=cds-CCP45083.1;Parent=gene-Rv2301;Dbxref=EnsemblGenomes-Gn:Rv2301,EnsemblGenomes-Tr:CCP45083,GOA:P9WP41,InterPro:IPR000675,InterPro:IPR006311,InterPro:IPR011150,InterPro:IPR029058,NCBI_GP:CCP45083.1;Name=CCP45083.1;Note=Rv2301%2C (MTCY339.08c)%2C len: 230 aa. Probable cut2 (alternate gene name: cfp25)%2C cutinase%2C highly similar to others from Mycobacteria tuberculosis e.g. MTCY13E12.04|Rv3451|O06318|CUT3_MYCTU (247 aa)%2C FASTA scores: opt: 569%2C E(): 2.3e-27%2C (45.3%25 identity in 223 aa overlap)%3B MT2037|MTCY39.35|RV1984C|Q10837|CUT1_MYCTU (217 aa)%2C FASTA scores: opt: 383%2C E(): 3.4e-16 (42.9%25 identity in 217 aa overlap)%3B O69691|Rv3724|MTV025.072 putative cutinase precursor (187 aa)%2C FASTA scores: opt: 248%2C E(): 4.3e-08%2C (41.85%25 identity in 172 aa overlap)%3B etc. Also similar to few others from other organisms e.g. Q9KK87 serine esterase cutinase from Mycobacterium avium (220 aa)%2CFASTA scores: opt: 391%2C E(): 1.1e-16%2C (39.15%25 identity in 235 aa overlap)%3B etc. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. Belongs to the cutinase family. Start changed since first submission (+11 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cut2;inference=protein motif:PROSITE:PS00095;locus_tag=Rv2301;product=Probable cutinase Cut2;protein_id=CCP45083.1;transl_table=11
AL123456.3	EMBL	gene	2573813	2574055	.	+	.	ID=gene-Rv2302;Name=Rv2302;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2302
AL123456.3	EMBL	CDS	2573813	2574055	.	+	0	ID=cds-CCP45084.1;Parent=gene-Rv2302;Dbxref=EnsemblGenomes-Gn:Rv2302,EnsemblGenomes-Tr:CCP45084,GOA:P9WLD5,InterPro:IPR011067,InterPro:IPR015035,PDB:2A7Y,NCBI_GP:CCP45084.1;Name=CCP45084.1;Note=Rv2302%2C (MTCY339.07c)%2C len: 80 aa. Conserved protein%2C highly similar to others: O53766|AL021942|Rv0569|MTV039.07 hypothetical 9.5 KDA protein from Mycobacterium tuberculosis (88 aa)%2C FASTA scores: opt: 300%2C E(): 1.4e-14%2C (61.85%25 identity in 76 aa overlap)%3B O88049|SCI35.11 hypothetical 7.1 KDA protein from Streptomyces coelicolor (64 aa)%2C FASTA scores: opt: 169%2CE(): 1.5e-05%2C (46.55%25 identity in 58 aa overlap) (has its C-terminus shorter)%3B Q9XCD1 hypothetical 12.0 KDA protein (fragment) from Thermomonospora fusca (106 aa)%2C FASTA scores: opt: 126%2C E(): 0.023%2C (50.0%25 identity in 34 aa overlap) (similarity in part for this one). Also weakly similar to U650M|G699303|Q50105 hypothetical 5.7 KDA protein from Mycobacterium leprae (53 aa)%2C FASTA scores: opt: 89%2C E(): 0.66%2C (45.5%25 identity in 33 aa overlap)%3B and weakly similar to N-terminus of Q9RIZ1|SCJ1.23c putative DNA-binding protein from Streptomyces coelicolor (323 aa)%2CFASTA scores: opt: 182%2C E(): 7.3e-06%2C (42.25%25 identity in 71 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2302;product=Conserved protein;protein_id=CCP45084.1;transl_table=11
AL123456.3	EMBL	gene	2574096	2575019	.	-	.	ID=gene-Rv2303c;Name=Rv2303c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2303c
AL123456.3	EMBL	CDS	2574096	2575019	.	-	0	ID=cds-CCP45085.1;Parent=gene-Rv2303c;Dbxref=EnsemblGenomes-Gn:Rv2303c,EnsemblGenomes-Tr:CCP45085,GOA:Q50662,InterPro:IPR006992,UniProtKB/TrEMBL:Q50662,NCBI_GP:CCP45085.1;Name=CCP45085.1;Note=Rv2303c%2C (MTCY339.06%2C MT2360)%2C len: 307 aa. Probable antibiotic-resistance protein%2C with some similarity to Q54229|G153373 macrotetrolide antibiotic-resistance protein (NONR) from Streptomyces griseus (347 aa) (see Plater and Robinson%2C 1992)%2C FASTA scores: opt: 438%2C E(): 3.1e-21%2C(33.2%25 identity in 226 aa overlap)%3B and other hypothetical proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa)%2C FASTA scores: opt: 252%2C E(): 3.5e-09%2C (25.5%25 identity in 286 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis Rv3510c|O53555|MTV023.17. Note that the protein Q9XDF3|NONC from Streptomyces griseus subsp. griseus (317 aa) is equivalent to Q54229|G153373|NONR however the N-terminal end is shorter (30 aa) owing to a changed start codon (see Walczak et al.%2C 2000). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2303c;product=Probable antibiotic-resistance protein;protein_id=CCP45085.1;transl_table=11
AL123456.3	EMBL	gene	2575016	2575225	.	-	.	ID=gene-Rv2304c;Name=Rv2304c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2304c
AL123456.3	EMBL	CDS	2575016	2575225	.	-	0	ID=cds-CCP45086.1;Parent=gene-Rv2304c;Dbxref=EnsemblGenomes-Gn:Rv2304c,EnsemblGenomes-Tr:CCP45086,NCBI_GP:CCP45086.1;Name=CCP45086.1;Note=Rv2304c%2C (MTCY339.05)%2C len: 69 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2304c;product=Hypothetical protein;protein_id=CCP45086.1;transl_table=11
AL123456.3	EMBL	gene	2575809	2577098	.	+	.	ID=gene-Rv2305;Name=Rv2305;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2305
AL123456.3	EMBL	CDS	2575809	2577098	.	+	0	ID=cds-CCP45087.1;Parent=gene-Rv2305;Dbxref=EnsemblGenomes-Gn:Rv2305,EnsemblGenomes-Tr:CCP45087,GOA:P9WLD1,InterPro:IPR001242,NCBI_GP:CCP45087.1;Name=CCP45087.1;Note=Rv2305%2C (MTCY339.04c)%2C len: 429 aa. Unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2305;product=Unknown protein;protein_id=CCP45087.1;transl_table=11
AL123456.3	EMBL	gene	2577108	2577701	.	+	.	ID=gene-Rv2306A;Name=Rv2306A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2306A
AL123456.3	EMBL	CDS	2577108	2577701	.	+	0	ID=cds-CCP45088.1;Parent=gene-Rv2306A;Dbxref=EnsemblGenomes-Gn:Rv2306A,EnsemblGenomes-Tr:CCP45088,UniProtKB/TrEMBL:Q79FG5,NCBI_GP:CCP45088.1;Name=CCP45088.1;Note=Rv2306A%2C len: 197 aa. Possible conserved membrane protein%2C similar to several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor%2C e.g. Rv0625c|P96915|Y625_MYCTU hypothetical 25.2 KDA protein from Mycobacterium tuberculosis (246 aa)%2CFASTA scores: opt: 410%2C E(): 2.7e-17%2C (53.25%25 identity in 139 aa overlap). First 140 aa show high similarity%2C this then decreases but continues in next ORF Rv2306B%2Csuggesting a frameshift near nt 2577473. However the sequence has been checked and no error found. The sequence is identical in CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2306A;product=Possible conserved membrane protein;protein_id=CCP45088.1;transl_table=11
AL123456.3	EMBL	gene	2577488	2577922	.	+	.	ID=gene-Rv2306B;Name=Rv2306B;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2306B
AL123456.3	EMBL	CDS	2577488	2577922	.	+	0	ID=cds-CCP45089.1;Parent=gene-Rv2306B;Dbxref=EnsemblGenomes-Gn:Rv2306B,EnsemblGenomes-Tr:CCP45089,InterPro:IPR015414,UniProtKB/TrEMBL:Q79FG4,NCBI_GP:CCP45089.1;Name=CCP45089.1;Note=Rv2306B%2C len: 144 aa. Possible conserved membrane protein%2C similar to C-terminal part of several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor e.g. P96915|Y625_MYCTU|RV0625c hypothetical 25.2 KDA protein from Mycobacterium tuberculosis (246 aa)%2C FASTA scores: opt: 480%2C E(): 5e-24%2C(77.15%25 identity in 92 aa overlap). Could be a continuation of Rv2306A suggesting there may be a frameshift near nt 2577473. The C-terminal part is longer than Rv0625c and the 3'-end of gene overlaps Rv2307c%2C so maybe a further framehift. However%2C sequence has been checked and no error found. Also same sequence as strain CDC1551 and Mycobacterium bovis. Replaces original Rv2306c on other strand. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2306B;product=Possible conserved membrane protein;protein_id=CCP45089.1;transl_table=11
AL123456.3	EMBL	gene	2577851	2578696	.	-	.	ID=gene-Rv2307c;Name=Rv2307c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2307c
AL123456.3	EMBL	CDS	2577851	2578696	.	-	0	ID=cds-CCP45090.1;Parent=gene-Rv2307c;Dbxref=EnsemblGenomes-Gn:Rv2307c,EnsemblGenomes-Tr:CCP45090,GOA:P9WLC7,InterPro:IPR029058,InterPro:IPR029059,NCBI_GP:CCP45090.1;Name=CCP45090.1;Note=Rv2307c%2C (MTCY339.02)%2C len: 281 aa. Conserved hypothetical protein%2C similar to many other hypothetical proteins and BEM1/BUD5 suppressors e.g. P77538 hypothetical protein from Escherichia coli (293 aa)%2C FASTA scores: opt: 421%2C E(): 2.4e-18%2C (32.1%25 identity in 268 aa overlap) (alias AAG57647|Z3802|BAB36823|ECS3400 Putative enzyme (3.4.-) from Escherichia coli (293 aa)%2C FASTA scores: opt: 425%2C E(): 1.7e-18%2C (32.1%25 identity in 268 aa overlap))%3BP54069|BE46_SCHPO|BEM46|SPBC32H8.03|PI020 BEM46 protein from Schizosaccharomyces pombe (Fission yeast) (352 aa)%2C FASTA scores: opt: 355%2C E(): 3.3e-14%2C (30.45%25 identity in 279 aa overlap)%3B O76462|BEM46 BEM46 protein from Drosophila melanogaster (338 aa)%2C FASTA scores: opt: 404%2CE(): 2.8e-17%2C (32.75%25 identity in 281 aa overlap)%3B etc. Equivalent (but with few differences) to AAK46650|MT2364 protein from Mycobacterium tuberculosis strain CDC1551 (281 aa). Predicted to be an outer membrane protein (See Song et al.%2C 2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2307c;product=Conserved hypothetical protein;protein_id=CCP45090.1;transl_table=11
AL123456.3	EMBL	gene	2579228	2579419	.	-	.	ID=gene-Rv2307A;Name=Rv2307A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2307A
AL123456.3	EMBL	CDS	2579228	2579419	.	-	0	ID=cds-CCP45091.1;Parent=gene-Rv2307A;Dbxref=EnsemblGenomes-Gn:Rv2307A,EnsemblGenomes-Tr:CCP45091,UniProtKB/TrEMBL:L7N678,NCBI_GP:CCP45091.1;Name=CCP45091.1;Note=Rv2307A%2C len: 63 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2307A;product=Hypothetical glycine rich protein;protein_id=CCP45091.1;transl_table=11
AL123456.3	EMBL	gene	2579504	2579935	.	-	.	ID=gene-Rv2307B;Name=Rv2307B;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2307B
AL123456.3	EMBL	CDS	2579504	2579935	.	-	0	ID=cds-CCP45092.1;Parent=gene-Rv2307B;Dbxref=EnsemblGenomes-Gn:Rv2307B,EnsemblGenomes-Tr:CCP45092,UniProtKB/TrEMBL:Q79FG2,NCBI_GP:CCP45092.1;Name=CCP45092.1;Note=Rv2307B%2C len: 143 aa. Hypothetical unknown Gly- rich protein. Equivalent to AAK46653 from Mycobacterium tuberculosis strain CDC1551 (133 aa) but longer 10 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2307B;product=Hypothetical glycine rich protein;protein_id=CCP45092.1;transl_table=11
AL123456.3	EMBL	gene	2580028	2580210	.	-	.	ID=gene-Rv2307D;Name=Rv2307D;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2307D
AL123456.3	EMBL	CDS	2580028	2580210	.	-	0	ID=cds-CCP45093.1;Parent=gene-Rv2307D;Dbxref=EnsemblGenomes-Gn:Rv2307D,EnsemblGenomes-Tr:CCP45093,UniProtKB/TrEMBL:L7N683,NCBI_GP:CCP45093.1;Name=CCP45093.1;Note=Rv2307D%2C len: 60 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2307D;product=Hypothetical protein;protein_id=CCP45093.1;transl_table=11
AL123456.3	EMBL	gene	2580419	2581135	.	+	.	ID=gene-Rv2308;Name=Rv2308;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2308
AL123456.3	EMBL	CDS	2580419	2581135	.	+	0	ID=cds-CCP45094.1;Parent=gene-Rv2308;Dbxref=EnsemblGenomes-Gn:Rv2308,EnsemblGenomes-Tr:CCP45094,GOA:P9WLC5,InterPro:IPR007367,InterPro:IPR009057,InterPro:IPR011991,InterPro:IPR017277,NCBI_GP:CCP45094.1;Name=CCP45094.1;Note=Rv2308%2C (MTCY339.01c)%2C len: 238 aa. Conserved hypothetical protein%2C sharing similarity with O53464|Rv2018|MTV018.05 from Mycobacterium tuberculosis (239 aa)%2C FASTA scores: opt: 142%2C E(): 0.034%2C (24.8%25 identity in 250 aa overlap). As contains possible helix-turn-helix motif at aa 16-37 (Sequence: YVYAEVDKLIGLPAGTAKRWIN) (Score 1169%2C +3.17 SD)%2C may be a transcriptional regulator. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2308;product=Conserved hypothetical protein;protein_id=CCP45094.1;transl_table=11
AL123456.3	EMBL	gene	2581764	2581837	.	-	.	ID=gene-metV;Name=metV;gbkey=Gene;gene=metV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2581764	2581837	.	-	.	ID=rna-metV;Parent=gene-metV;Note=codon recognized: AUG%3B metV%2C tRNA-Met%2C anticodon cat%2C length %3D 74. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;anticodon=(pos:complement(2581801..2581803));gbkey=tRNA;gene=metV;product=tRNA-Met
AL123456.3	EMBL	exon	2581764	2581837	.	-	.	ID=exon-metV-1;Parent=rna-metV;Note=codon recognized: AUG%3B metV%2C tRNA-Met%2C anticodon cat%2C length %3D 74. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;anticodon=(pos:complement(2581801..2581803));gbkey=tRNA;gene=metV;product=tRNA-Met
AL123456.3	EMBL	gene	2581843	2582298	.	-	.	ID=gene-Rv2309c;Name=Rv2309c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2309c
AL123456.3	EMBL	CDS	2581843	2582298	.	-	0	ID=cds-CCP45095.1;Parent=gene-Rv2309c;Dbxref=EnsemblGenomes-Gn:Rv2309c,EnsemblGenomes-Tr:CCP45095,GOA:P71903,InterPro:IPR002104,InterPro:IPR011010,InterPro:IPR013762,InterPro:IPR014417,UniProtKB/TrEMBL:P71903,NCBI_GP:CCP45095.1;Name=CCP45095.1;Note=Rv2309c%2C (MTCY3G12.25)%2C len: 151 aa. Possible integrase (fragment)%2C similar to others e.g. Q48908 integrase (fragment) from Mycobacterium paratuberculos (191 aa)%2C FASTA scores: opt: 279%2C E(): 3.2e-11%2C (40.4%25 identity in 136 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv1055|MTV017.08 integrase (fragment) (78 aa) (72.85%25 identity in 70 aa overlap)%3B and Rv1054|MTV017.07 integrase (fragment). Could belong to the 'phage' integrase family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2309c;product=Possible integrase (fragment);protein_id=CCP45095.1;transl_table=11
AL123456.3	EMBL	gene	2583045	2583332	.	+	.	ID=gene-Rv2309A;Name=Rv2309A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2309A
AL123456.3	EMBL	CDS	2583045	2583332	.	+	0	ID=cds-CCP45096.1;Parent=gene-Rv2309A;Dbxref=EnsemblGenomes-Gn:Rv2309A,EnsemblGenomes-Tr:CCP45096,UniProtKB/TrEMBL:L7N666,NCBI_GP:CCP45096.1;Name=CCP45096.1;Note=Rv2309A%2C len: 95 aa. Hypothetical unknown protein. Equivalent to AAK46663 from Mycobacterium tuberculosis strain CDC1551 (95 aa) but longer 13 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2309A;product=Hypothetical protein;protein_id=CCP45096.1;transl_table=11
AL123456.3	EMBL	gene	2583435	2583779	.	+	.	ID=gene-Rv2310;Name=Rv2310;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2310
AL123456.3	EMBL	CDS	2583435	2583779	.	+	0	ID=cds-CCP45097.1;Parent=gene-Rv2310;Dbxref=EnsemblGenomes-Gn:Rv2310,EnsemblGenomes-Tr:CCP45097,GOA:P9WLC3,InterPro:IPR009061,InterPro:IPR010093,NCBI_GP:CCP45097.1;Name=CCP45097.1;Note=Rv2310%2C (MT2372%2C MTCY3G12.24c)%2C len: 114 aa. Possible excisionase%2C showing some similarity to others e.g. Q9LCU5 putative excisionase from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 341%2C E(): 6.6e-15%2C (48.2%25 identity in 110 aa overlap)%3B O85865 putative excisionase from Sphingomonas aromaticivorans (152 aa)%2C FASTA scores: opt: 205%2C E(): 2.2e-06%2C (41.25%25 identity in 80 aa overlap)%3B etc. Also similar to Rv3750c|O69717 hypothetical protein from Mycobacterium tuberculosis (130 aa)%2C FASTA scores: opt: 228%2C E(): 6.9e-08%2C (43.9%25 identity in 82 aa overlap). Contains possible helix-turn-helix motif at aa 20-41 (Score 2181%2C +6.62 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2310;product=Possible excisionase;protein_id=CCP45097.1;transl_table=11
AL123456.3	EMBL	gene	2583884	2584408	.	+	.	ID=gene-Rv2311;Name=Rv2311;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2311
AL123456.3	EMBL	CDS	2583884	2584408	.	+	0	ID=cds-CCP45098.1;Parent=gene-Rv2311;Dbxref=EnsemblGenomes-Gn:Rv2311,EnsemblGenomes-Tr:CCP45098,InterPro:IPR027417,NCBI_GP:CCP45098.1;Name=CCP45098.1;Note=Rv2311%2C (MTCY3G12.23c)%2C len: 174 aa. Conserved hypothetical protein%2C with similarity (in part) to transfer proteins homologous TRAA e.g. Q9EUN8|TRAA transfer protein homolog TRAA from Corynebacterium glutamicum (1160 aa)%2CFASTA scores: opt: 221%2C E(): 2.9e-07%2C (36.8%25 identity in 136 aa overlap)%3B Q9ETQ3|TRAA conjugal transfer protein (TRAA-like protein) from Corynebacterium equii (1367 aa)%2CFASTA scores: opt: 188%2C E(): 5.5e-05%2C (33%25 identity in 106 aa overlap)%3B P55418|TRAA_RHISN|Y4DS probable conjugal transfer protein from Rhizobium sp. strain NGR234 (1102 aa)%2C FASTA scores: opt: 145%2C E(): 0.035%2C (29.08%25 identity in 141 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2311;product=Conserved hypothetical protein;protein_id=CCP45098.1;transl_table=11
AL123456.3	EMBL	gene	2584486	2584755	.	+	.	ID=gene-Rv2312;Name=Rv2312;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2312
AL123456.3	EMBL	CDS	2584486	2584755	.	+	0	ID=cds-CCP45099.1;Parent=gene-Rv2312;Dbxref=EnsemblGenomes-Gn:Rv2312,EnsemblGenomes-Tr:CCP45099,NCBI_GP:CCP45099.1;Name=CCP45099.1;Note=Rv2312%2C (MTCY3G12.22c)%2C len: 89 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2312;product=Hypothetical protein;protein_id=CCP45099.1;transl_table=11
AL123456.3	EMBL	gene	2585052	2585906	.	-	.	ID=gene-Rv2313c;Name=Rv2313c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2313c
AL123456.3	EMBL	CDS	2585052	2585906	.	-	0	ID=cds-CCP45100.1;Parent=gene-Rv2313c;Dbxref=EnsemblGenomes-Gn:Rv2313c,EnsemblGenomes-Tr:CCP45100,InterPro:IPR029032,NCBI_GP:CCP45100.1;Name=CCP45100.1;Note=Rv2313c%2C (MTCY3G12.21)%2C len: 284 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2313c;product=Hypothetical protein;protein_id=CCP45100.1;transl_table=11
AL123456.3	EMBL	gene	2585917	2587290	.	-	.	ID=gene-Rv2314c;Name=Rv2314c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2314c
AL123456.3	EMBL	CDS	2585917	2587290	.	-	0	ID=cds-CCP45101.1;Parent=gene-Rv2314c;Dbxref=EnsemblGenomes-Gn:Rv2314c,EnsemblGenomes-Tr:CCP45101,GOA:P71898,InterPro:IPR002510,UniProtKB/TrEMBL:P71898,NCBI_GP:CCP45101.1;Name=CCP45101.1;Note=Rv2314c%2C (MTCY3G12.20)%2C len: 457 aa. Conserved protein%2C highly similar to Q9RJ51|SCI8.02 hypothetical protein from Streptomyces coelicolor (464 aa) FASTA scores: opt: 1485%2C E(): 5.2e-83%2C (53.5%25 identity in 454 aa overlap)%3B similar to AAK24788|CC2824 TldD/PmbA family protein from Caulobacter crescentus (441 aa)%2C FASTA scores: opt: 364%2C E(): 8.3e-15%2C (29.8%25 identity in 460 aa overlap)%3B and showing similarity with Q9HJZ6|TA0814 hypothetical protein from Thermoplasma acidophilum (430 aa)%2C FASTA scores: opt: 220%2C E(): 4.7e-06%2C (21.85%25 identity in 348 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2314c;product=Conserved protein;protein_id=CCP45101.1;transl_table=11
AL123456.3	EMBL	gene	2587287	2588804	.	-	.	ID=gene-Rv2315c;Name=Rv2315c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2315c
AL123456.3	EMBL	CDS	2587287	2588804	.	-	0	ID=cds-CCP45102.1;Parent=gene-Rv2315c;Dbxref=EnsemblGenomes-Gn:Rv2315c,EnsemblGenomes-Tr:CCP45102,InterPro:IPR002510,UniProtKB/TrEMBL:P71897,NCBI_GP:CCP45102.1;Name=CCP45102.1;Note=Rv2315c%2C (MTCY3G12.19)%2C len: 505 aa. Conserved protein%2C highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa)%2CFASTA scores: opt: 1768%2C E():5.6e-101%2C (63.2%25 identity in 432 overlap)%3B and similar to others e.g. AAK24787|CC2823 hypothetical protein (TldD/PmbA family) from Caulobacter crescentus (543 aa)%2C FASTA scores: opt: 876%2C E():3.1e-46%2C(42.8%25 identity in 505 overlap)%3B O58578|PH0848 hypothetical 54.4 KDA protein from Pyrococcus horikoshii (481 aa)%2C FASTA scores: opt: 661%2C E(): 4.3e-33%2C (29.95%25 identity in 484 aa overlap)%3B Q9UZ95|PAB1547 hypothetical 53.6 KDA protein from Pyrococcus abyssi (473 aa)%2C FASTA scores: opt: 656%2C E(): 8.6e-33%2C (29.1%25 identity in 481 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2315c;product=Conserved protein;protein_id=CCP45102.1;transl_table=11
AL123456.3	EMBL	gene	2588838	2589710	.	+	.	ID=gene-Rv2316;Name=uspA;gbkey=Gene;gene=uspA;gene_biotype=protein_coding;locus_tag=Rv2316
AL123456.3	EMBL	CDS	2588838	2589710	.	+	0	ID=cds-CCP45103.1;Parent=gene-Rv2316;Dbxref=EnsemblGenomes-Gn:Rv2316,EnsemblGenomes-Tr:CCP45103,GOA:P71896,InterPro:IPR000515,UniProtKB/TrEMBL:P71896,NCBI_GP:CCP45103.1;Name=CCP45103.1;Note=Rv2316%2C (MTCY3G12.18c)%2C len: 290 aa. Probable uspA%2Csugar-transport integral membrane protein ABC transporter (see citation below)%2C most similar to Q9CBN8|USPA|ML1768 sugar transport integral membrane protein from Mycobacterium leprae (328 aa)%2C FASTA scores: opt: 1593%2CE(): 1.9e-93%2C (82.35%25 identity in 289 aa overlap)%3B and similar to O32940|ML1426|MLCB2052.28 possible sugar transport protein (probable ABC-transport protein%2C inner membrane component) from Mycobacterium leprae (319 aa)%2CFASTA scores: opt: 600%2C E(): 9.2e-31%2C (34.25%25 identity in 295 aa overlap). Also similar to other proteins involved in transport e.g. Q9X860|SCE134.05c putative binding protein dependent transport protein from Streptomyces coelicolor (327 aa)%2C FASTA scores: opt: 639%2C E(): 3.2e-33%2C (40.45%25 identity in 272 aa overlap)%3B Q9K6N9|BH3689 sugar transport system (permease) from Bacillus halodurans (300 aa)%2C FASTA scores: opt: 590%2C E(): 3.7e-30%2C (35.65%25 identity in 289 aa overlap)%3B etc.;gbkey=CDS;gene=uspA;locus_tag=Rv2316;product=Probable sugar-transport integral membrane protein ABC transporter UspA;protein_id=CCP45103.1;transl_table=11
AL123456.3	EMBL	gene	2589697	2590521	.	+	.	ID=gene-Rv2317;Name=uspB;gbkey=Gene;gene=uspB;gene_biotype=protein_coding;locus_tag=Rv2317
AL123456.3	EMBL	CDS	2589697	2590521	.	+	0	ID=cds-CCP45104.1;Parent=gene-Rv2317;Dbxref=EnsemblGenomes-Gn:Rv2317,EnsemblGenomes-Tr:CCP45104,GOA:L7N652,InterPro:IPR000515,UniProtKB/TrEMBL:L7N652,NCBI_GP:CCP45104.1;Name=CCP45104.1;Note=Rv2317%2C (MTC3G12.17c)%2C len: 274 aa. Probable uspB%2Csugar-transport integral membrane protein ABC transporter (see citation below)%2C most similar to Q9CBN7|USPE|ML1769 sugar transport integral membrane protein from Mycobacterium leprae (274 aa)%2C FASTA scores: opt: 1522%2CE(): 3.4e-89%2C (85.0%25 identity in 274 aa overlap)%3B and similar to O32941|ML1425|MLCB2052.29 probable ABC-transport protein%2C inner membrane component from Mycobacterium leprae (283 aa)%2C FASTA scores: opt: 630%2C E(): 8.4e-33%2C (36.55%25 identity in 268 aa overlap). Also similar to other integral membrane proteins e.g. P73854|LACG|SLR1723 lactose transport system permease protein from Synechocystis sp. strain PCC 6803 (270 aa)%2C FASTA scores: opt: 605%2C E(): 3.1e-31%2C (36.0%25 identity in 264 aa overlap)%3B Q9F3B8|SC5F1.11 putative sugar transport integral membrane protein from Streptomyces coelicolor (307 aa)%2C FASTA scores: opt: 582%2C E(): 9.7e-30%2C (34.45%25 identity in 264 aa overlap)%3B etc. Also similar to O53483|Rv2039c|MTV018.26c sugar transport protein from Mycobacterium tuberculosis (280 aa)%2C FASTA scores: opt: 630%2C E(): 8.3e-89%2C (37.7%25 identity in 268 aa overlap).;gbkey=CDS;gene=uspB;locus_tag=Rv2317;product=Probable sugar-transport integral membrane protein ABC transporter UspB;protein_id=CCP45104.1;transl_table=11
AL123456.3	EMBL	gene	2590518	2591840	.	+	.	ID=gene-Rv2318;Name=uspC;gbkey=Gene;gene=uspC;gene_biotype=protein_coding;locus_tag=Rv2318
AL123456.3	EMBL	CDS	2590518	2591840	.	+	0	ID=cds-CCP45105.1;Parent=gene-Rv2318;Dbxref=EnsemblGenomes-Gn:Rv2318,EnsemblGenomes-Tr:CCP45105,GOA:P71894,InterPro:IPR006059,UniProtKB/TrEMBL:P71894,NCBI_GP:CCP45105.1;Name=CCP45105.1;Note=Rv2318%2C (MTCY3G12.16c)%2C len: 440 aa. Probable uspC%2Csugar-binding lipoprotein component of sugar transport system (see citation below)%2C most similar to Q9CBN6|USPC|ML1770 sugar transport periplasmic binding protein from Mycobacterium leprae (446 aa)%2C FASTA scores: opt: 2294%2C E(): 8.1e-135%2C (74.7%25 identity in 446 aa overlap). Also similar to other substrate-binding proteins e.g. Q9RK89|SCF1.15 putative substrate binding protein (extracellular) (binding-protein-dependent transport) (fragment) from Streptomyces coelicolor (221 aa)%2C FASTA scores: opt: 377%2C E(): 3e-16%2C (32.25%25 identity in 217 aa overlap)%3B Q9K6N8|BH3690 sugar transport system (sugar-binding protein) from Bacillus halodurans (420 aa)%2CFASTA scores: opt: 227%2C E(): 1e-06%2C (25.00%25 identity in 452 aa overlap)%3B etc. Also similar to O53485|Rv2041c|MTV018.28C lipoprotein component of sugar transport system from Mycobacterium tuberculosis (439 aa)%2C FASTA scores: opt: 246%2C E(): 7e-08%2C (26.75%25 identity in 325 aa overlap). Contains a hydrophobic stretch (possible signal peptide) at N-terminal end.;gbkey=CDS;gene=uspC;locus_tag=Rv2318;product=Probable periplasmic sugar-binding lipoprotein UspC;protein_id=CCP45105.1;transl_table=11
AL123456.3	EMBL	gene	2591848	2592726	.	-	.	ID=gene-Rv2319c;Name=Rv2319c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2319c
AL123456.3	EMBL	CDS	2591848	2592726	.	-	0	ID=cds-CCP45106.1;Parent=gene-Rv2319c;Dbxref=EnsemblGenomes-Gn:Rv2319c,EnsemblGenomes-Tr:CCP45106,GOA:P9WLB5,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,NCBI_GP:CCP45106.1;Name=CCP45106.1;Note=Rv2319c%2C (MTCY3G12.15)%2C len: 292 aa. Universal stress protein family protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2319c;product=Universal stress protein family protein;protein_id=CCP45106.1;transl_table=11
AL123456.3	EMBL	gene	2592723	2594153	.	-	.	ID=gene-Rv2320c;Name=rocE;gbkey=Gene;gene=rocE;gene_biotype=protein_coding;locus_tag=Rv2320c
AL123456.3	EMBL	CDS	2592723	2594153	.	-	0	ID=cds-CCP45107.1;Parent=gene-Rv2320c;Dbxref=EnsemblGenomes-Gn:Rv2320c,EnsemblGenomes-Tr:CCP45107,GOA:P71892,InterPro:IPR002293,UniProtKB/TrEMBL:P71892,NCBI_GP:CCP45107.1;Name=CCP45107.1;Note=Rv2320c%2C (MTCY3G12.14)%2C len: 476 aa. Probable rocE%2Ccationic amino acid (especially arginine and ornithine) transporter (permease)%2C highly similar to other amino acid transporters e.g. Q9L100|SCL6.16C putative amino acid transporter from Streptomyces coelicolor (496 aa)%2C FASTA scores: opt: 1485%2C E(): 9.4e-82%2C (48.4%25 identity in 477 aa overlap)%3B O06479|YFNA putative amino acid transporter from Bacillus subtilis (462 aa)%2C FASTA scores: opt: 1271%2C E(): 6.1e-69%2C (41.9%25 identity in 463 aa overlap)%3B Q9PG94|XF0408 amino acid transporter from Xylella fastidiosa (509 aa)%2CFASTA scores: opt: 1128%2C E(): 2.5e-60%2C (39.5%25 identity in 481 aa overlap)%3B etc. Also some similarity with Z99108.1|BSUB0005 from Bacillus subtilis (461 aa)%2C FASTA scores: opt: 1271%2C E(): 0%2C (41.9%25 identity in 463 aa overlap)%3B and G403170 ethanolamine permease (488 aa)%2C FASTA scores: opt: 468%2C E(): 1e-23%2C (28.1%25 identity in 462 aa overlap). Seems to belong to the APC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rocE;locus_tag=Rv2320c;product=Probable cationic amino acid transport integral membrane protein RocE;protein_id=CCP45107.1;transl_table=11
AL123456.3	EMBL	gene	2594154	2594699	.	-	.	ID=gene-Rv2321c;Name=rocD2;gbkey=Gene;gene=rocD2;gene_biotype=protein_coding;locus_tag=Rv2321c
AL123456.3	EMBL	CDS	2594154	2594699	.	-	0	ID=cds-CCP45108.1;Parent=gene-Rv2321c;Dbxref=EnsemblGenomes-Gn:Rv2321c,EnsemblGenomes-Tr:CCP45108,GOA:P71891,InterPro:IPR005814,InterPro:IPR010164,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:P71891,NCBI_GP:CCP45108.1;Name=CCP45108.1;Note=Rv2321c%2C (MTCY3G12.13)%2C len: 181 aa. Probable rocD2%2Cornithine aminotransferase%2C highly similar to C-terminal region of other ornithine aminotransferases%2C e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa)%2C FASTA scores: opt: 628%2C E(): 1.2e-32%2C (55.35%25 identity in 168 aa overlap)%3B P3802|OAT_BACSU|ROCD from Bacillus subtilis (401 aa)%2C FASTA scores: opt: 477%2C E(): 4.3e-23%2C (42.1%25 identity in 178 aa overlap)%3B BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa)%2C FASTA scores: opt: 437%2C E(): 1.5e-20%2C (41.3%25 identity in 170 aa overlap)%3B etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Rv2322c|MTCY3G12.12 (upstream ORF) and Rv2321c|MTCY3G12.13 appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this.;gbkey=CDS;gene=rocD2;inference=protein motif:PROSITE:PS00600;locus_tag=Rv2321c;product=Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase);protein_id=CCP45108.1;transl_table=11
AL123456.3	EMBL	gene	2594699	2595364	.	-	.	ID=gene-Rv2322c;Name=rocD1;gbkey=Gene;gene=rocD1;gene_biotype=protein_coding;locus_tag=Rv2322c
AL123456.3	EMBL	CDS	2594699	2595364	.	-	0	ID=cds-CCP45109.1;Parent=gene-Rv2322c;Dbxref=EnsemblGenomes-Gn:Rv2322c,EnsemblGenomes-Tr:CCP45109,GOA:P71890,InterPro:IPR005814,InterPro:IPR010164,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:P71890,NCBI_GP:CCP45109.1;Name=CCP45109.1;Note=Rv2322c%2C (MTCY3G12.12)%2C len: 221 aa. Probable rocD1%2Cornithine aminotransferase%2C highly similar to N-terminal region of other ornithine aminotransferases%2C e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa)%2C FASTA scores: opt: 770%2C E(): 8.7e-40%2C (55.7%25 identity in 201 aa overlap)%3B BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa) FASTA scores: opt: 632%2C E(): 2.2e-31%2C (46.1%25 identity in 208 aa overlap)%3B P38021|OAT_BACSU|ROCD from Bacillus subtilis (401 aa)%2CFASTA scores: opt: 626%2C E(): 5.1e-31%2C (43.1%25 identity in 218 aa overlap)%3B etc. Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Rv2322c|MTCY3G12.12 and Rv2321c|MTCY3G12.13 (upstream ORF) appear to be an ornithine aminotransferase homologue but are frameshifted - we can find no sequence error in the cosmid to account for this.;gbkey=CDS;gene=rocD1;locus_tag=Rv2322c;product=Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase);protein_id=CCP45109.1;transl_table=11
AL123456.3	EMBL	gene	2595361	2596269	.	-	.	ID=gene-Rv2323c;Name=Rv2323c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2323c
AL123456.3	EMBL	CDS	2595361	2596269	.	-	0	ID=cds-CCP45110.1;Parent=gene-Rv2323c;Dbxref=EnsemblGenomes-Gn:Rv2323c,EnsemblGenomes-Tr:CCP45110,GOA:P71889,InterPro:IPR003198,UniProtKB/TrEMBL:P71889,NCBI_GP:CCP45110.1;Name=CCP45110.1;Note=Rv2323c%2C (MTCY3G12.11)%2C len: 302 aa. Conserved protein%2C highly similar to others e.g. Q9FC91|2SCG58.22 conserved hypothetical protein from Streptomyces coelicolor (288 aa)%2C FASTA scores: opt: 561%2C E(): 7.3e-28%2C (46.95%25 identity in 279 aa overlap)%3B P74535|SLL1336 hypothetical 78.3 KDA protein from Synechocystis sp. (705 aa)%2C FASTA scores: opt: 555%2C E(): 2.1e-27%2C (37.75%25 identity in 265 aa overlap)%3B etc. Also similar to various hydrolases e.g. Q53797 beta-hydroxylase (bleomycin/phleomycin binding protein%2C ankyrin homologue%2C bleomycin and transport protein) from Streptomyces verticillus (326 aa)%2C FASTA scores: opt: 211%2C E(): 4.5e-06%2C (26.75%25 identity in 303 aa overlap)%3B Q9X7M4|DDAH_STRCO|SC5F2A.01c NG%2CNG-dimethylarginine dimethylaminohydrolase (Dimethylargininase) (Dimethylarginine dimethylaminohydrolase) (258 aa)%2C FASTA scores: opt: 209%2CE(): 4.9e-06%2C (27.15%25 identity in 243 aa overlap)%3B G434715 beta-hydroxylase (bleomicin/phleomycin binding protein) from Streptomyces verticillus (326 aa)%2C FASTA scores: opt: 211%2C E(): 4.5e-06%2C (26.75%25 identity in 303 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2323c;product=Conserved protein;protein_id=CCP45110.1;transl_table=11
AL123456.3	EMBL	gene	2596334	2596780	.	+	.	ID=gene-Rv2324;Name=Rv2324;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2324
AL123456.3	EMBL	CDS	2596334	2596780	.	+	0	ID=cds-CCP45111.1;Parent=gene-Rv2324;Dbxref=EnsemblGenomes-Gn:Rv2324,EnsemblGenomes-Tr:CCP45111,GOA:P71888,InterPro:IPR000485,InterPro:IPR011008,InterPro:IPR011991,InterPro:IPR019887,InterPro:IPR019888,UniProtKB/TrEMBL:P71888,NCBI_GP:CCP45111.1;Name=CCP45111.1;Note=Rv2324%2C (MTCY3G12.10)%2C len: 148 aa. Probable transcriptional regulatory protein%2C asnC-family%2C similar to other putative AsnC-family regulatory proteins e.g. Q9L101|SCL6.15C from Streptomyces coelicolor (150 aa) FASTA scores: opt: 466%2C E(): 2.4e-24%2C (52.8%25 identity in 142 aa overlap)%3B Q9RKY4|SC6D7.14 putative AsnC-family transcriptional regulatory protein from Streptomyces coelicolor (165 aa)%2C FASTA scores: opt: 266%2C E(): 5.5e-11%2C(32.4%25 identity in 145 aa overlap)%3B Q9ZEP1|LRPA|SCE94.12c putative transcriptional regulator from Streptomyces coelicolor (150 aa)%2C FASTA scores: opt: 249%2C E(): 6.9e-10%2C(33.35%25 identity in 147 aa overlap)%3B etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (150 aa)%2C FASTA scores: opt: 261%2C E(): 1.1e-10%2C (36.4%25 identity in 143 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2324;product=Probable transcriptional regulatory protein (probably AsnC-family);protein_id=CCP45111.1;transl_table=11
AL123456.3	EMBL	gene	2597009	2597857	.	-	.	ID=gene-Rv2325c;Name=Rv2325c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2325c
AL123456.3	EMBL	CDS	2597009	2597857	.	-	0	ID=cds-CCP45112.1;Parent=gene-Rv2325c;Dbxref=EnsemblGenomes-Gn:Rv2325c,EnsemblGenomes-Tr:CCP45112,GOA:P9WPI7,InterPro:IPR003339,NCBI_GP:CCP45112.1;Name=CCP45112.1;Note=Rv2325c%2C (MTCY3G12.09)%2C len: 282 aa. Conserved hypothetical protein%2C equivalent to O32970|MLCB22.37c|ML0849 hypothetical protein from Mycobacterium leprae (283 aa)%2C FASTA scores: opt: 1405%2CE(): 1.8e-78%2C (77.7%25 identity in 282 aa overlap). Also some similarity to other proteins e.g. Q9Z9J1|YBAF|BH0166 YBAF protein (BH0166 protein) (hypothetical protein) from Bacillus halodurans (265 aa)%2C FASTA scores: opt: 288%2C E(): 2.8e-10%2C (25.8%25 identity in 264 aa overlap)%3B P70972|YBAF YBAF protein (hypothetical protein) from Bacillus subtilis (265 aa)%2C FASTA scores: opt: 259%2C E(): 1.5e-08%2C (25.45%25 identity in 224 aa overlap)%3B AAK34821|SPY2193|Q99X13 Conserved hypothetical protein from Streptococcus pyogenes (266 aa)%2C FASTA scores: opt: 232%2C E(): 6.5e-07%2C (25.1%25 identity in 267 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2325c;product=Conserved hypothetical protein;protein_id=CCP45112.1;transl_table=11
AL123456.3	EMBL	gene	2597854	2599947	.	-	.	ID=gene-Rv2326c;Name=Rv2326c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2326c
AL123456.3	EMBL	CDS	2597854	2599947	.	-	0	ID=cds-CCP45113.1;Parent=gene-Rv2326c;Dbxref=EnsemblGenomes-Gn:Rv2326c,EnsemblGenomes-Tr:CCP45113,GOA:P9WQI7,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP45113.1;Name=CCP45113.1;Note=Rv2326c%2C (MTC3G12.08)%2C len: 697 aa. Possible transmembrane ATP-binding protein ABC transporter (see citation below). Equivalent to Q9CCF9|ML0848 ABC transporter from Mycobacterium leprae (724 aa)%2C FASTA scores: opt: 3482%2C E(): 2.8e-182%2C (76.9%25 identity in 697 aa overlap) and also to O32971|MLCB22.38c ABC-type transporter from Mycobacterium leprae (726 aa)%2C FASTA scores: opt: 3482%2C E(): 2.8e-182%2C (76.9%25 identity in 697 aa overlap). Similar in part to other ABC transporters e.g. Q9WY65|TM0222 from Thermotoga maritima (266 aa)%2C FASTA scores: opt: 407%2C E(): 4.2e-15%2C (38.0%25 identity in 213 aa overlap)%3B etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop)%3B and 2 x PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv2326c;product=Possible transmembrane ATP-binding protein ABC transporter;protein_id=CCP45113.1;transl_table=11
AL123456.3	EMBL	gene	2599988	2600479	.	+	.	ID=gene-Rv2327;Name=Rv2327;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2327
AL123456.3	EMBL	CDS	2599988	2600479	.	+	0	ID=cds-CCP45114.1;Parent=gene-Rv2327;Dbxref=EnsemblGenomes-Gn:Rv2327,EnsemblGenomes-Tr:CCP45114,GOA:P71885,InterPro:IPR000835,InterPro:IPR011991,UniProtKB/TrEMBL:P71885,NCBI_GP:CCP45114.1;Name=CCP45114.1;Note=Rv2327%2C (MTCY3G12.07c)%2C len: 163 aa. Conserved protein%2C similar to Z80775|MTCY21D4.05c|Rv0042c from Mycobacterium tuberculosis (208 aa)%2C FASTA scores: opt: 242%2C E(): 5e-08%2C (43.0%25 identity in 107 aa overlap). Also slight similarity to putative transcriptional regulatory proteins belonging to the MarR-family e.g. Q9CCY2/ML2696 from Mycobacterium leprae (243 aa)%2C FASTA scores: opt: 245%2CE(): 3.7e-08%2C (35.35%25 identity in 150 aa overlap)%3B Q9L135|SC6D11.20 from Streptomyces coelicolor (155 aa)%2CFASTA scores: opt: 242%2C E(): 3.9e-08%2C (34.75%25 identity in 141 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2327;product=Conserved protein;protein_id=CCP45114.1;transl_table=11
AL123456.3	EMBL	gene	2600731	2601879	.	+	.	ID=gene-Rv2328;Name=PE23;gbkey=Gene;gene=PE23;gene_biotype=protein_coding;locus_tag=Rv2328
AL123456.3	EMBL	CDS	2600731	2601879	.	+	0	ID=cds-CCP45115.1;Parent=gene-Rv2328;Dbxref=EnsemblGenomes-Gn:Rv2328,EnsemblGenomes-Tr:CCP45115,GOA:P9WIG9,InterPro:IPR000084,NCBI_GP:CCP45115.1;Name=CCP45115.1;Note=Rv2328%2C (MTCY3G12.06)%2C len: 382 aa. PE23%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa)%2C FASTA scores: opt: 495%2C E(): 6.6e-18%2C (34.65%25 identity in 401 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE23;locus_tag=Rv2328;product=PE family protein PE23;protein_id=CCP45115.1;transl_table=11
AL123456.3	EMBL	gene	2601914	2603461	.	-	.	ID=gene-Rv2329c;Name=narK1;gbkey=Gene;gene=narK1;gene_biotype=protein_coding;locus_tag=Rv2329c
AL123456.3	EMBL	CDS	2601914	2603461	.	-	0	ID=cds-CCP45116.1;Parent=gene-Rv2329c;Dbxref=EnsemblGenomes-Gn:Rv2329c,EnsemblGenomes-Tr:CCP45116,GOA:P71883,InterPro:IPR011701,InterPro:IPR016196,UniProtKB/TrEMBL:P71883,NCBI_GP:CCP45116.1;Name=CCP45116.1;Note=Rv2329c%2C (MTCY3G12.05)%2C len: 515 aa. Probable narK1%2Cnitrite extrusion protein%2C possibly member of major facilitator superfamily (MFS). Equivalent to O32974|MLCB22.41c|nark|ML0844 putative nitrite extrusion protein from Mycobacterium leprae (517 aa)%2C FASTA scores: opt: 2224%2C E(): 1.9e-129%2C (69.3%25 identity in 488 aa overlap). Also highly similar to others e.g. P94933 nitrite extrusion protein from Mycobacterium fortuitum (471 aa)%2CFASTA scores: opt: 1969%2C E(): 8.6e-114%2C (62.1%25 identity in 459 aa overlap)%3B P37758|NARU_ECOLI nitrite extrusion protein 2 from Escherichia coli strain K12 (462 aa)%2C FASTA scores: opt: 792%2C E(): 2.3e-41%2C (36.95%25 identity in 476 aa overlap)%3B P10903|NARK_ECOLI nitrite extrusion protein (nitrite facilitator 1) from Escherichia coli strain K12 (463 aa)%2C FASTA scores: opt: 784%2C E(): 7e-41%2C (35.3%25 identity in 468 aa overlap)%3B etc. Also similar to RV0261c|Z86089|MTCY6A4_5 from Mycobacterium tuberculosis (469 aa)%2C FASTA scores: opt: 2000%2C E(): 1.1e-115%2C (62.6%25 identity in 470 aa overlap). Belongs to the nark/NASA family of transporters.;gbkey=CDS;gene=narK1;locus_tag=Rv2329c;product=Probable nitrite extrusion protein 1 NarK1 (nitrite facilitator 1);protein_id=CCP45116.1;transl_table=11
AL123456.3	EMBL	gene	2603695	2604222	.	-	.	ID=gene-Rv2330c;Name=lppP;gbkey=Gene;gene=lppP;gene_biotype=protein_coding;locus_tag=Rv2330c
AL123456.3	EMBL	CDS	2603695	2604222	.	-	0	ID=cds-CCP45117.1;Parent=gene-Rv2330c;Dbxref=EnsemblGenomes-Gn:Rv2330c,EnsemblGenomes-Tr:CCP45117,GOA:P9WK69,InterPro:IPR020217,InterPro:IPR025971,NCBI_GP:CCP45117.1;Name=CCP45117.1;Note=Rv2330c%2C (MTCY3G12.04)%2C len: 175 aa. Probable lppP%2Clipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppP;locus_tag=Rv2330c;product=Probable lipoprotein LppP;protein_id=CCP45117.1;transl_table=11
AL123456.3	EMBL	gene	2604297	2604683	.	+	.	ID=gene-Rv2331;Name=Rv2331;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2331
AL123456.3	EMBL	CDS	2604297	2604683	.	+	0	ID=cds-CCP45118.1;Parent=gene-Rv2331;Dbxref=EnsemblGenomes-Gn:Rv2331,EnsemblGenomes-Tr:CCP45118,NCBI_GP:CCP45118.1;Name=CCP45118.1;Note=Rv2331%2C (MT2393%2C MTCY3G12.03c)%2C len: 128 aa. Hypothetical unknown protein%3B shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2331;product=Hypothetical protein;protein_id=CCP45118.1;transl_table=11
AL123456.3	EMBL	gene	2604740	2605078	.	+	.	ID=gene-Rv2331A;Name=Rv2331A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2331A
AL123456.3	EMBL	CDS	2604740	2605078	.	+	0	ID=cds-CCP45119.1;Parent=gene-Rv2331A;Dbxref=EnsemblGenomes-Gn:Rv2331A,EnsemblGenomes-Tr:CCP45119,UniProtKB/TrEMBL:Q79FF7,NCBI_GP:CCP45119.1;Name=CCP45119.1;Note=Rv2331A%2C len: 112 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2331A;product=Hypothetical protein;protein_id=CCP45119.1;transl_table=11
AL123456.3	EMBL	gene	2605108	2606754	.	+	.	ID=gene-Rv2332;Name=mez;gbkey=Gene;gene=mez;gene_biotype=protein_coding;locus_tag=Rv2332
AL123456.3	EMBL	CDS	2605108	2606754	.	+	0	ID=cds-CCP45120.1;Parent=gene-Rv2332;Dbxref=EnsemblGenomes-Gn:Rv2332,EnsemblGenomes-Tr:CCP45120,GOA:P9WK25,InterPro:IPR001891,InterPro:IPR012301,InterPro:IPR012302,InterPro:IPR015884,InterPro:IPR016040,NCBI_GP:CCP45120.1;Name=CCP45120.1;Note=Rv2332%2C (MTCY3G12.02c%2C MTCY98.01%2C MT2394)%2C len: 548 aa. Probable mez%2C malate oxidoreductase [NAD] dependent (malic enzyme)%2C highly similar to others e.g. O34389|MALS putative malolactic enzyme [includes: malic enzyme %3B L-lactate dehydrogenase] from Bacillus subtilis (566 aa)%2CFASTA scores: opt: 1927%2C E(): 5.5e-111%2C (52.9%25 identity in 539 aa overlap)%3B P45868|MAO2_BACSU|YWKA probable NAD-dependent malic enzyme from Bacillus subtilis (582 aa)%2CFASTA scores: opt: 1849%2C E(): 3.6e-106%2C (50.45%25 identity in 543 aa overlap)%3B Q48796|MLES_OENOE malolactic enzyme from Oenococcus oeni (541 aa)%2C FASTA scores: opt: 1540%2C E(): 3.6e-87%2C (44.2%25 identity in 536 aa overlap)%3B etc. Belongs to the malic enzymes family. N-terminus shortened since first submission (previously 652 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mez;locus_tag=Rv2332;product=Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarboxylating)) (pyruvic-malic carboxylase) (NAD-me);protein_id=CCP45120.1;transl_table=11
AL123456.3	EMBL	gene	2606708	2608321	.	-	.	ID=gene-Rv2333c;Name=stp;gbkey=Gene;gene=stp;gene_biotype=protein_coding;locus_tag=Rv2333c
AL123456.3	EMBL	CDS	2606708	2608321	.	-	0	ID=cds-CCP45121.1;Parent=gene-Rv2333c;Dbxref=EnsemblGenomes-Gn:Rv2333c,EnsemblGenomes-Tr:CCP45121,GOA:P9WG91,InterPro:IPR001411,InterPro:IPR004638,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP45121.1;Name=CCP45121.1;Note=Rv2333c%2C (MTCY3G12.01)%2C len: 537 aa. stp%2C integral membrane drug efflux protein (See Ramon-Garcia et al.%2C2007)%2C member of major facilitator superfamily (MFS)%2Chighly similar to many e.g. Q9RL22|C5G9.04c putative transmembrane efflux protein from Streptomyces coelicolor (489 aa)%2C FASTA scores: opt: 1031%2C E(): 4e-55%2C (37.4%25 identity in 412 aa overlap)%3B Q9L0L9|SCD82.12 putative transmembrane efflux protein from Streptomyces coelicolor (490 aa)%2C FASTA scores: opt: 883%2C E(): 3.8e-46%2C (36.35%25 identity in 407 aa overlap)%3B Q9ZBW5|SC4B5.03c putative integral membrane efflux protein from Streptomyces coelicolor (504 aa)%2C FASTA scores: opt: 899%2C E(): 4.1e-47%2C(37.4%25 identity in 415 aa overlap)%3B P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa)%2C FASTA scores: opt: 839%2CE(): 1.9e-43%2C (32.3%25 identity in 489 aa overlap)%3B etc. Also highly similar to Rv2459|O53186|MTV008.15 probable conserved integral membrane transport protein from Mycobacterium tuberculosis strain H37Rv (508 aa)%2C FASTA scores: opt: 1385%2C E(): 1.5e-76%2C (44.05%25 identity in 504 aa overlap)%3B and AAK46834|MT2534 drug transporter from Mycobacterium tuberculosis strain CDC1551 (523 aa)%2C FASTA scores: opt: 1385%2C E(): 1.5e-76%2C (44.4%25 identity in 504 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=stp;locus_tag=Rv2333c;product=Integral membrane drug efflux protein Stp;protein_id=CCP45121.1;transl_table=11
AL123456.3	EMBL	gene	2608796	2609728	.	+	.	ID=gene-Rv2334;Name=cysK1;gbkey=Gene;gene=cysK1;gene_biotype=protein_coding;gene_synonym=cysK;locus_tag=Rv2334
AL123456.3	EMBL	CDS	2608796	2609728	.	+	0	ID=cds-CCP45122.1;Parent=gene-Rv2334;Dbxref=EnsemblGenomes-Gn:Rv2334,EnsemblGenomes-Tr:CCP45122,GOA:P9WP55,InterPro:IPR001216,InterPro:IPR001926,InterPro:IPR005856,InterPro:IPR005859,PDB:2Q3B,PDB:2Q3C,PDB:2Q3D,PDB:3ZEI,NCBI_GP:CCP45122.1;Name=CCP45122.1;Note=Rv2334%2C (MT2397%2C MTCY98.03)%2C len: 310 aa. cysK1%2Ccysteine synthase A%2C equivalent to O32978|CYSK_MYCLE|ML0839|MLCB22.47 cysteine synthase a from Mycobacterium leprae (310 aa)%2C FASTA scores: opt: 1756%2CE(): 8.6e-96%2C (85.8%25 identity in 310 aa overlap). Also highly similar to other cysteine synthases e.g. Q9JQL6|CYSK|NMA0974|NMB0763 putative cysteine synthase from Neisseria meningitidis (serogroup a and B) (310 aa)%2C FASTA scores: opt: 1368%2C E(): 4.6e-73%2C (66.45%25 identity in 310 aa overlap)%3B P73410|CYSK_SYNY3|SLR1842 from Synechocystis sp (312 aa)%2C FASTA scores: opt: 1310%2C E(): 1.2e-69%2C (64.65%25 identity in 311 aa overlap)%3B Q43725|CYSM_ARATH|OASC|ACS1|AT3G59760|F24G16.30 cysteine synthase (mitochondrial precursor) from Arabidopsis thaliana (Mouse-ear cress) (424 aa)%2C FASTA scores: opt: 1253%2C E(): 3.2e-66%2C (59.2%25 identity in 309 aa overlap) (has its N-terminus longer 104 aa)%3B etc. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. Belongs to the cysteine synthase/cystathionine beta-synthase family. Note that previously known as cysK.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysK1;inference=protein motif:PROSITE:PS00901;locus_tag=Rv2334;product=Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A);protein_id=CCP45122.1;transl_table=11
AL123456.3	EMBL	gene	2609732	2610421	.	+	.	ID=gene-Rv2335;Name=cysE;gbkey=Gene;gene=cysE;gene_biotype=protein_coding;locus_tag=Rv2335
AL123456.3	EMBL	CDS	2609732	2610421	.	+	0	ID=cds-CCP45123.1;Parent=gene-Rv2335;Dbxref=EnsemblGenomes-Gn:Rv2335,EnsemblGenomes-Tr:CCP45123,GOA:P95231,InterPro:IPR001451,InterPro:IPR005881,InterPro:IPR011004,InterPro:IPR018357,NCBI_GP:CCP45123.1;Name=CCP45123.1;Note=Rv2335%2C (MTCY98.04)%2C len: 229 aa. Probable cysE%2Cserine acetyltransferase%2C equivalent to O32979|CYSE|ML0838 serine acetyltransferase from Mycobacterium leprae (227 aa)%2C FASTA scores: opt: 1152%2C E(): 9.6e-62%2C (76.4%25 identity in 229 aa overlap). Also highly similar%2C except in C-terminal part%2C to others e.g. Q9HXI6|CYSE|PA3816 O-acetylserine synthase from Pseudomonas aeruginosa (258 aa)%2C FASTA scores: opt: 737%2C E(): 6e-37%2C (61.3%25 identity in 168 aa overlap)%3B P23145|NIFP_AZOCH probable serine acetyltransferase from Azotobacter chroococcum mcd 1 (269 aa)%2C FASTA scores: opt: 718%2C E(): 8.4e-36%2C (55.45%25 identity in 220 aa overlap)%3B Q06750|CYSE_BACSU serine acetyltransferase from Bacillus subtilis (217 aa)%2C FASTA scores: opt: 640%2C E(): 3.1e-31%2C (48.0%25 identity in 200 aa overlap)%3B etc. Contains PS00101 Bacterial hexapeptide-repeat containing-transferases signature. Belongs to the CYSE/LACA/LPXA/NODL family of acetyltransferases. Composed of multiple repeats of [LIV]-G-X(4).;gbkey=CDS;gene=cysE;inference=protein motif:PROSITE:PS00101;locus_tag=Rv2335;product=Probable serine acetyltransferase CysE (sat);protein_id=CCP45123.1;transl_table=11
AL123456.3	EMBL	gene	2610837	2611805	.	+	.	ID=gene-Rv2336;Name=Rv2336;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2336
AL123456.3	EMBL	CDS	2610837	2611805	.	+	0	ID=cds-CCP45124.1;Parent=gene-Rv2336;Dbxref=EnsemblGenomes-Gn:Rv2336,EnsemblGenomes-Tr:CCP45124,GOA:P95232,UniProtKB/TrEMBL:P95232,NCBI_GP:CCP45124.1;Name=CCP45124.1;Note=Rv2336%2C (MTCY98.05)%2C len: 322 aa. Hypothetical unknown protein (see Rindi et al.%2C 2001). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2336;product=Hypothetical protein;protein_id=CCP45124.1;transl_table=11
AL123456.3	EMBL	gene	2611869	2612987	.	-	.	ID=gene-Rv2337c;Name=Rv2337c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2337c
AL123456.3	EMBL	CDS	2611869	2612987	.	-	0	ID=cds-CCP45125.1;Parent=gene-Rv2337c;Dbxref=EnsemblGenomes-Gn:Rv2337c,EnsemblGenomes-Tr:CCP45125,GOA:P95233,UniProtKB/TrEMBL:P95233,NCBI_GP:CCP45125.1;Name=CCP45125.1;Note=Rv2337c%2C (MTCY98.06c)%2C len: 372 aa. Hypothetical unknown protein%2C sharing some similarity with Q9RI33|SCJ12.27c hypothetical 37.2 KDA protein from Streptomyces coelicolor (335 aa)%2C blast scores: 134 and 46%2C(28%25 and 33%25 identity%2C 52%25 and 44%25 positive)%3B FASTA scores: opt: 176%2C E(): 0.00042%2C (31.95%25 identity in 355 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2337c;product=Hypothetical protein;protein_id=CCP45125.1;transl_table=11
AL123456.3	EMBL	gene	2613107	2614063	.	-	.	ID=gene-Rv2338c;Name=moeW;gbkey=Gene;gene=moeW;gene_biotype=protein_coding;locus_tag=Rv2338c
AL123456.3	EMBL	CDS	2613107	2614063	.	-	0	ID=cds-CCP45126.1;Parent=gene-Rv2338c;Dbxref=EnsemblGenomes-Gn:Rv2338c,EnsemblGenomes-Tr:CCP45126,GOA:P95234,InterPro:IPR000594,InterPro:IPR009036,InterPro:IPR016040,UniProtKB/TrEMBL:P95234,NCBI_GP:CCP45126.1;Name=CCP45126.1;Note=Rv2338c%2C (MTCY98.07c)%2C len: 318 aa. Possible moeW%2Cmolybdoptenum biosynthesis protein%2C showing some similarity to several molybdopterin biosynthesis proteins e.g. O27613|MTH1571 molybdopterin biosynthesis protein MOEB homolog from Methanobacterium thermoautotrophicum (251 aa)%2CFASTA scores: opt: 309%2C E(): 4.7e-14%3B (30.7%25 identity in 254 aa overlap)%3B Q9KPQ5|VC2311 HESA/MOEB/THIF family protein from Vibrio cholerae (273 aa)%2C FASTA scores: opt: 255%2C E(): 4e-09%2C (36.25%25 identity in 149 aa overlap)%3B Q9PD34|XF1545 molybdopterin biosynthesis protein from Xylella fastidiosa (276 aa)%2C FASTA scores: opt: 233%2CE(): 1e-07%2C (33.6%25 identity in 128 aa overlap)%3B etc. Seems to belong to the HESA/MOEB/THIF family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=moeW;locus_tag=Rv2338c;product=Possible molybdopterin biosynthesis protein MoeW;protein_id=CCP45126.1;transl_table=11
AL123456.3	EMBL	gene	2614693	2617581	.	+	.	ID=gene-Rv2339;Name=mmpL9;gbkey=Gene;gene=mmpL9;gene_biotype=protein_coding;locus_tag=Rv2339
AL123456.3	EMBL	CDS	2614693	2617581	.	+	0	ID=cds-CCP45127.1;Parent=gene-Rv2339;Dbxref=EnsemblGenomes-Gn:Rv2339,EnsemblGenomes-Tr:CCP45127,GOA:P9WJU3,InterPro:IPR004707,InterPro:IPR004869,NCBI_GP:CCP45127.1;Name=CCP45127.1;Note=Rv2339%2C (MTCY98.08)%2C len: 962 aa. Probable mmpL9%2Cconserved transmembrane transport protein (see citation below)%2C with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical 105.2 kDa protein from Mycobacterium leprae (959 aa)%2C FASTA scores: opt: 3799%2C E(): 0%2C (59.3%25 identity in 937 aa overlap)%3B G699237|U1740AB from Mycobacterium leprae%3B and MTCY20G9.34%3B MTCY48.08c%3B MTCY19G5.06 from Mycobacterium tuberculosis. Belongs to the MmpL family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL9;locus_tag=Rv2339;product=Probable conserved transmembrane transport protein MmpL9;protein_id=CCP45127.1;transl_table=11
AL123456.3	EMBL	gene	2617667	2618908	.	-	.	ID=gene-Rv2340c;Name=PE_PGRS39;gbkey=Gene;gene=PE_PGRS39;gene_biotype=protein_coding;locus_tag=Rv2340c
AL123456.3	EMBL	CDS	2617667	2618908	.	-	0	ID=cds-CCP45128.1;Parent=gene-Rv2340c;Dbxref=EnsemblGenomes-Gn:Rv2340c,EnsemblGenomes-Tr:CCP45128,InterPro:IPR000084,UniProtKB/TrEMBL:L7N659,NCBI_GP:CCP45128.1;Name=CCP45128.1;Note=Rv2340c%2C (MTCY98.09c)%2C len: 413 aa. PE_PGRS39%2CMember of the Mycobacterium tuberculosis PE_family%2C PGRS subfamily of gly-rich proteins (see citations below)%2Csimilar to others eg YI18_MYCTU|Q50615|Rv1818c|MTCY1A11.25 PE-PGRS family protein from Mycobacterium tuberculosis (498 aa)%2C FASTA scores: opt: 710%2C E(): 1.4e-22%2C (41.0%25 identity in 368 aa overlap)%3B O53884|Rv0872v|MTV043.65c PGRS-family protein from Mycobacterium tuberculosis (606 aa)%2C FASTA scores: opt: 708%2C E(): 1.9e-22%2C (42.4%25 identity in 389 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS39;locus_tag=Rv2340c;product=PE-PGRS family protein PE_PGRS39;protein_id=CCP45128.1;transl_table=11
AL123456.3	EMBL	gene	2619407	2619479	.	-	.	ID=gene-asnT;Name=asnT;gbkey=Gene;gene=asnT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2619407	2619479	.	-	.	ID=rna-asnT;Parent=gene-asnT;Note=codon recognized: AAC%3B asnT%2C tRNA-Asn%2C anticodon gtt%2C length %3D 73;anticodon=(pos:complement(2619444..2619446));gbkey=tRNA;gene=asnT;product=tRNA-Asn
AL123456.3	EMBL	exon	2619407	2619479	.	-	.	ID=exon-asnT-1;Parent=rna-asnT;Note=codon recognized: AAC%3B asnT%2C tRNA-Asn%2C anticodon gtt%2C length %3D 73;anticodon=(pos:complement(2619444..2619446));gbkey=tRNA;gene=asnT;product=tRNA-Asn
AL123456.3	EMBL	gene	2619597	2620016	.	+	.	ID=gene-Rv2341;Name=lppQ;gbkey=Gene;gene=lppQ;gene_biotype=protein_coding;locus_tag=Rv2341
AL123456.3	EMBL	CDS	2619597	2620016	.	+	0	ID=cds-CCP45129.1;Parent=gene-Rv2341;Dbxref=EnsemblGenomes-Gn:Rv2341,EnsemblGenomes-Tr:CCP45129,UniProtKB/TrEMBL:P95237,NCBI_GP:CCP45129.1;Name=CCP45129.1;Note=Rv2341%2C (MTCY98.10)%2C len: 139 aa. Probable lppQ%2Cconserved lipoprotein%2C showing some similarity with Rv1228|O33224|LPQX|MTCI61.11 from Mycobacterium tuberculosis (185 aa)%2C FASTA scores: opt: 155%3B E(): 0.0073%3B (31.9%25 identity in 116 aa overlap). Also shows few similarity with P29228|VLPA_MYCHR variant surface antigen a precursor from Mycoplasma hyorhinis (157 aa)%2C FASTA scores: opt: 96%2C E(): 7.3%2C (23.1%25 identity in 143 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lppQ;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2341;product=Probable conserved lipoprotein LppQ;protein_id=CCP45129.1;transl_table=11
AL123456.3	EMBL	gene	2620272	2620529	.	+	.	ID=gene-Rv2342;Name=Rv2342;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2342
AL123456.3	EMBL	CDS	2620272	2620529	.	+	0	ID=cds-CCP45130.1;Parent=gene-Rv2342;Dbxref=EnsemblGenomes-Gn:Rv2342,EnsemblGenomes-Tr:CCP45130,UniProtKB/TrEMBL:P95238,NCBI_GP:CCP45130.1;Name=CCP45130.1;Note=Rv2342%2C (MTCY98.11)%2C len: 85 aa. Conserved hypothetical protein%2C highly similar to Q9CCG1|ML0834 hypothetical protein from Mycobacterium leprae (100 aa)%2CFASTA scores: opt: 392%2C E(): 2.9e-20%2C (78.2%25 identity in 78 aa overlap). N-terminus highly similar to N-terminal part of Q9L085|SCC24.32 putative secreted protein from Streptomyces coelicolor (108 aa)%2C FASTA scores: opt: 122%2CE(): 0.077%2C (39.15%25 identity in 46 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2342;product=Conserved hypothetical protein;protein_id=CCP45130.1;transl_table=11
AL123456.3	EMBL	gene	2620533	2622452	.	-	.	ID=gene-Rv2343c;Name=dnaG;gbkey=Gene;gene=dnaG;gene_biotype=protein_coding;locus_tag=Rv2343c
AL123456.3	EMBL	CDS	2620533	2622452	.	-	0	ID=cds-CCP45131.1;Parent=gene-Rv2343c;Dbxref=EnsemblGenomes-Gn:Rv2343c,EnsemblGenomes-Tr:CCP45131,GOA:P9WNW1,InterPro:IPR002694,InterPro:IPR006171,InterPro:IPR006295,InterPro:IPR013173,InterPro:IPR013264,InterPro:IPR019475,NCBI_GP:CCP45131.1;Name=CCP45131.1;Note=Rv2343c%2C (MTCY98.12c)%2C len: 639 aa. Probable dnaG%2CDNA primase%2C equivalent to O52200|PRIM_MYCSM|DNAG DNA primase from Mycobacterium smegmatis (636 aa)%2C FASTA scores: opt: 3504%2C E(): 5.5e-202%2C (81.55%25 identity in 639 aa overlap)%3B and Q9CCG2|DNAG|ML0833 DNA primase from Mycobacterium leprae (642 aa)%2C FASTA scores: opt: 3443%2CE(): 2.5e-198%2C (80.4%25 identity in 642 aa overlap). Also highly similar to many DNA primases e.g. Q9S1N4|PRIM_STRCO|DNAG|SC7A8.07c from Streptomyces coelicolor (641 aa)%2C FASTA scores: opt: 1899%2C E(): 5.1e-106%2C (47.9%25 identity in 643 aa overlap)%3B P74893|PRIM_SYNP7|DNAG from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (616 aa)%2C FASTA scores: opt: 860%2C E(): 6.6e-44%2C (35.3%25 identity in 513 aa overlap)%3B P05096|PRIM_BACSU from Bacillus subtilis (603 aa) FASTA scores: opt: 800%2C E(): 2.5e-40%2C (33.7%25 identity in 430 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaG;locus_tag=Rv2343c;product=Probable DNA primase DnaG;protein_id=CCP45131.1;transl_table=11
AL123456.3	EMBL	gene	2622457	2623752	.	-	.	ID=gene-Rv2344c;Name=dgt;gbkey=Gene;gene=dgt;gene_biotype=protein_coding;locus_tag=Rv2344c
AL123456.3	EMBL	CDS	2622457	2623752	.	-	0	ID=cds-CCP45132.1;Parent=gene-Rv2344c;Dbxref=EnsemblGenomes-Gn:Rv2344c,EnsemblGenomes-Tr:CCP45132,GOA:P9WNY7,InterPro:IPR003607,InterPro:IPR006261,InterPro:IPR006674,InterPro:IPR023023,InterPro:IPR023293,InterPro:IPR026875,NCBI_GP:CCP45132.1;Name=CCP45132.1;Note=Rv2344c%2C (MT2409%2C MTCY98.13c)%2C len: 431 aa. Probable dgt%2C deoxyguanosine triphosphate triphosphohydrolase%2Cequivalent to Q9CCG3|DGT|ML0831 putative deoxyguanosine triphosphate triphosphohydrolase from Mycobacterium leprae (429 aa)%2C FASTA scores: opt: 2316%2C E(): 1.6e-137%2C (83.85%25 identity in 421 aa overlap)%3B and O52199|DGTP_MYCSM|AF027507_2 deoxyguanosinetriphosphate triphosphohydrolase from Mycobacterium smegmatis (428 aa)%2CFASTA scores: opt: 1991%2C E(): 3.4e-117%2C (73.5%25 identity in 422 aa overlap). Also highly similar or similar to several deoxyguanosine triphosphate hydrolases e.g. Q9L2E9|SC7A8.09c putative deoxyguanosinetriphosphate triphosphohydrolase from Streptomyces coelicolor (424 aa)%2CFASTA scores: opt: 1216%2C E(): 1e-68%2C (51.05%25 identity in 425 aa overlap)%3B BAB48544|MLL1093 dGTP triphosphohydrolase from Rhizobium loti (Mesorhizobium loti) (404 aa)%2C FASTA scores: opt: 489%2C E(): 3.1e-23%2C (33.85%25 identity in 387 aa overlap)%3B P15723|DGTP_ECOLI|DGT|B0160 from Escherichia coli strain K12 (504 aa)%2C FASTA scores: opt: 173%2C E(): 0.0022%2C(31.65%25 identity in 259 aa overlap)%3B etc. Belongs to the dGTPase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dgt;locus_tag=Rv2344c;product=Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase);protein_id=CCP45132.1;transl_table=11
AL123456.3	EMBL	gene	2623821	2625803	.	+	.	ID=gene-Rv2345;Name=Rv2345;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2345
AL123456.3	EMBL	CDS	2623821	2625803	.	+	0	ID=cds-CCP45133.1;Parent=gene-Rv2345;Dbxref=EnsemblGenomes-Gn:Rv2345,EnsemblGenomes-Tr:CCP45133,GOA:P9WFJ5,InterPro:IPR007621,NCBI_GP:CCP45133.1;Name=CCP45133.1;Note=Rv2345%2C (MTCY98.14)%2C len: 660 aa. Possible conserved transmembrane protein%2C with hydrophobic stretch at N-terminal end around position 180. Similar to O52198 hypothetical 21.2 KDA protein (fragment) from Mycobacterium smegmatis (195 aa)%2C FASTA scores: opt: 589%2C E(): 1.5e-23%3B (47.2%25 identity in 195 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2345;product=Possible conserved transmembrane protein;protein_id=CCP45133.1;transl_table=11
AL123456.3	EMBL	gene	2625888	2626172	.	-	.	ID=gene-Rv2346c;Name=esxO;gbkey=Gene;gene=esxO;gene_biotype=protein_coding;gene_synonym=ES6_6,Mtb9.9E;locus_tag=Rv2346c
AL123456.3	EMBL	CDS	2625888	2626172	.	-	0	ID=cds-CCP45134.1;Parent=gene-Rv2346c;Dbxref=EnsemblGenomes-Gn:Rv2346c,EnsemblGenomes-Tr:CCP45134,GOA:P9WNI7,InterPro:IPR009416,InterPro:IPR010310,PDB:3OGI,PDB:4GZR,NCBI_GP:CCP45134.1;Name=CCP45134.1;Note=Rv2346c%2C (MT2411%2C MTCY98.15c)%2C len: 94 aa. EsxO%2CESAT-6 like protein (see citation below)%2C member of Mycobacterium tuberculosis protein family with O53942|Rv1793|MTV049.15%2C O05300|Rv1198|MTCI364.10%2CMTCY15C10.33%2C P96364|MTCY07H7B.03|Rv1037c|MTCY10G2.12%2CMTCI364.10%2C etc. Belongs to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxO;locus_tag=Rv2346c;product=Putative ESAT-6 like protein EsxO (ESAT-6 like protein 6);protein_id=CCP45134.1;transl_table=11
AL123456.3	EMBL	gene	2626223	2626519	.	-	.	ID=gene-Rv2347c;Name=esxP;gbkey=Gene;gene=esxP;gene_biotype=protein_coding;gene_synonym=ES6_7,QILSS;locus_tag=Rv2347c
AL123456.3	EMBL	CDS	2626223	2626519	.	-	0	ID=cds-CCP45135.1;Parent=gene-Rv2347c;Dbxref=EnsemblGenomes-Gn:Rv2347c,EnsemblGenomes-Tr:CCP45135,InterPro:IPR010310,PDB:3OGI,PDB:4GZR,NCBI_GP:CCP45135.1;Name=CCP45135.1;Note=Rv2347c%2C (MT2412%2C MTCY98.16c)%2C len: 98 aa. EsxP%2CESAT-6 like protein (see citation below). Member of M. tuberculosis hypothetical QILSS protein family with Rv1197%2CRv1792%2C Rv1038c and Rv3620c. Belongs to the ESAT6 family. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=esxP;locus_tag=Rv2347c;product=Putative ESAT-6 like protein EsxP (ESAT-6 like protein 7);protein_id=CCP45135.1;transl_table=11
AL123456.3	EMBL	gene	2626654	2626980	.	-	.	ID=gene-Rv2348c;Name=Rv2348c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2348c
AL123456.3	EMBL	CDS	2626654	2626980	.	-	0	ID=cds-CCP45136.1;Parent=gene-Rv2348c;Dbxref=EnsemblGenomes-Gn:Rv2348c,EnsemblGenomes-Tr:CCP45136,UniProtKB/TrEMBL:P95244,NCBI_GP:CCP45136.1;Name=CCP45136.1;Note=Rv2348c%2C (MTCY98.17c)%2C len: 108 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2348c;product=Hypothetical protein;protein_id=CCP45136.1;transl_table=11
AL123456.3	EMBL	gene	2627172	2628698	.	-	.	ID=gene-Rv2349c;Name=plcC;gbkey=Gene;gene=plcC;gene_biotype=protein_coding;locus_tag=Rv2349c
AL123456.3	EMBL	CDS	2627172	2628698	.	-	0	ID=cds-CCP45137.1;Parent=gene-Rv2349c;Dbxref=EnsemblGenomes-Gn:Rv2349c,EnsemblGenomes-Tr:CCP45137,GOA:P9WIB1,InterPro:IPR006311,InterPro:IPR007312,NCBI_GP:CCP45137.1;Name=CCP45137.1;Note=Rv2349c%2C (MT2414%2C MTCY98.18c)%2C len: 508 aa. Probable plcC%2C phospolipase C 3 (see citations below)%2C similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C precursor from Pseudomonas aeruginosa (692 aa)%2C FASTA scores: opt: 1013%2C E(): 9.3e-54%2C (38.85%25 identity in 525 aa overlap)%3B P06200|PHLC_PSEAE hemolytic phospholipase C precursor from Pseudomonas aeruginosa (730 aa)%2C FASTA scores: opt: 630%2C E(): 1.5e-30%2C (35.15%25 identity in 535 aa overlap)%3B Q9S816|T12J13.18|T21P5.4 putative phospholipase from Arabidopsis thaliana (Mouse-ear cress) (521 aa)%2C FASTA scores: opt: 218%2C E(): 1e-05%2C (27.05%25 identity in 451 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C phospholipase C 4 (514 aa)%2C FASTA scores: opt: 2497%2C E(): 9e-144%2C (68.35%25 identity in 509 aa overlap)%3B Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase C 1 (520 aa)%2C FASTA scores: opt: 2494%2C E(): 1.4e-143%2C (68.1%25 identity in 514 aa overlap)%3B P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c phospholipase C 2 (512 aa)%2C FASTA scores: opt: 2474%2C E(): 2.2e-142%2C (67.65%25 identity in 513 aa overlap)%3B etc. Belongs to the bacterial phospholipase C family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=plcC;locus_tag=Rv2349c;product=Probable phospholipase C 3 PlcC;protein_id=CCP45137.1;transl_table=11
AL123456.3	EMBL	gene	2628781	2630319	.	-	.	ID=gene-Rv2350c;Name=plcB;gbkey=Gene;gene=plcB;gene_biotype=protein_coding;gene_synonym=mpcB;locus_tag=Rv2350c
AL123456.3	EMBL	CDS	2628781	2630319	.	-	0	ID=cds-CCP45138.1;Parent=gene-Rv2350c;Dbxref=EnsemblGenomes-Gn:Rv2350c,EnsemblGenomes-Tr:CCP45138,GOA:P9WIB3,InterPro:IPR006311,InterPro:IPR007312,NCBI_GP:CCP45138.1;Name=CCP45138.1;Note=Rv2350c%2C (MT2415%2C MTCY98.19c)%2C len: 512 aa. plcB (alternate gene name: mpcB)%2C membrane-associated phospolipase C 2 (see citations below)%2C similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C precursor from Pseudomonas aeruginosa (692 aa)%2C FASTA scores: opt: 885%2C E(): 2.3e-44%2C (38.5%25 identity in 525 aa overlap)%3B P06200|PHLC_PSEAE hemolytic phospholipase C precursor from Pseudomonas aeruginosa (730 aa)%2C FASTA scores: opt: 639%2C E(): 6.3e-30%2C (537 aa overlap)%3B Q9RGS8 non-hemolytic phospholipase C from Pseudomonas aeruginosa (700 aa)%2C FASTA scores: opt: 864%2C E(): 3.9e-43%2C (39.2%25 identity in 528 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase C 1 (520 aa)%2C FASTA scores: opt: 2788%2C E(): 4.5e-156%2C (75.5%25 identity in 514 aa overlap)%3B Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C phospholipase C 4 (514 aa)%2C FASTA scores: opt: 2623%2C E(): 2.1e-146%2C (71.5%25 identity in 512 aa overlap)%3B P95245|PLCC|Rv2349c|MT2414|MTCY98.18c phospholipase C 3 (508 aa)%2C FASTA scores: opt: 2474%2C E(): 1.1e-137%2C (67.65%25 identity in 513 aa overlap)%3B etc. Belongs to the bacterial phospholipase C family. Supposed membrane-associated%2C at the extracellular side. Substrate of Tat pathway (See McDonough et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=plcB;locus_tag=Rv2350c;product=Membrane-associated phospholipase C 2 PlcB;protein_id=CCP45138.1;transl_table=11
AL123456.3	EMBL	gene	2630537	2632075	.	-	.	ID=gene-Rv2351c;Name=plcA;gbkey=Gene;gene=plcA;gene_biotype=protein_coding;gene_synonym=mpcA;locus_tag=Rv2351c
AL123456.3	EMBL	CDS	2630537	2632075	.	-	0	ID=cds-CCP45139.1;Parent=gene-Rv2351c;Dbxref=EnsemblGenomes-Gn:Rv2351c,EnsemblGenomes-Tr:CCP45139,GOA:P9WIB5,InterPro:IPR006311,InterPro:IPR007312,NCBI_GP:CCP45139.1;Name=CCP45139.1;Note=Rv2351c%2C (MTP40%2C MT2416%2C MTCY98.20c)%2C len: 512 aa. plcA (alternate gene name: mpcA)%2C membrane-associated phospolipase C 1 (MTP40 antigen) (see citations below)%2Csimilar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C precursor from Pseudomonas aeruginosa (692 aa)%2C FASTA scores: opt: 1064%2C E(): 4.3e-55%2C (39.85%25 identity in 517 aa overlap)%3B P06200|PHLC_PSEAE hemolytic phospholipase C precursor from Pseudomonas aeruginosa (730 aa)%2C FASTA scores: opt: 562%2C E(): 1.6e-25%2C (35.35%25 identity in 481 aa overlap)%3B Q9RGS8|PLCN|PHLN_BURPS non-hemolytic phospholipase C from Burkholderia pseudomallei (Pseudomonas pseudomallei) (700 aa)%2C FASTA scores: opt: 843%2C E(): 4.4e-42%2C (40.5%25 identity in 531 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c phospholipase C 2 (512 aa)%2C FASTA scores: opt: 2788%2C E(): 1.2e-156%2C (75.5%25 identity in 514 aa overlap) (alias Q50561|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c phospholipase C 2 (521 aa)%2C FASTA scores: opt: 2700%2C E(): 1.8e-151%2C (73.8%25 identity in 515 aa overlap))%3B Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C phospholipase C 4 (514 aa)%2C FASTA scores: opt: 2643%2C E(): 4.1e-148%2C (71.6%25 identity in 511 aa overlap)%3B etc. Belongs to the bacterial phospholipase C family. Supposed membrane-associated%2C at the extracellular side.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=plcA;locus_tag=Rv2351c;product=Membrane-associated phospholipase C 1 PlcA (MTP40 antigen);protein_id=CCP45139.1;transl_table=11
AL123456.3	EMBL	gene	2632923	2634098	.	-	.	ID=gene-Rv2352c;Name=PPE38;gbkey=Gene;gene=PPE38;gene_biotype=protein_coding;locus_tag=Rv2352c
AL123456.3	EMBL	CDS	2632923	2634098	.	-	0	ID=cds-CCP45140.1;Parent=gene-Rv2352c;Dbxref=EnsemblGenomes-Gn:Rv2352c,EnsemblGenomes-Tr:CCP45140,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP45140.1;Name=CCP45140.1;Note=Rv2352c%2C (MTCY98.21c)%2C len: 391 aa. PPE38%2C Member of Mycobacterium tuberculosis PPE_family%2C highly similar to many e.g. Q10778|MTCY48.17|Y04H_MYCTU (734 aa)%2C FASTA scores: opt: 713%2C E(): 2.8e-27%2C (37.7%25 identity in 430 aa overlap)%3B Q10540|MTCY31.06c%2C Q11031|MTCY02B10.25c%2CQ10813|MTCY274.23c%2C P42611|MTV037.06C%2C P71868|MTCY03C7.23%2CP95248|MTCY98.22c%2C P71869|MTCY03C7.24c%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE38;locus_tag=Rv2352c;product=PPE family protein PPE38;protein_id=CCP45140.1;transl_table=11
AL123456.3	EMBL	gene	2634528	2635592	.	-	.	ID=gene-Rv2353c;Name=PPE39;gbkey=Gene;gene=PPE39;gene_biotype=protein_coding;locus_tag=Rv2353c
AL123456.3	EMBL	CDS	2634528	2635592	.	-	0	ID=cds-CCP45141.1;Parent=gene-Rv2353c;Dbxref=EnsemblGenomes-Gn:Rv2353c,EnsemblGenomes-Tr:CCP45141,InterPro:IPR002989,UniProtKB/TrEMBL:Q79FF3,NCBI_GP:CCP45141.1;Name=CCP45141.1;Note=Rv2353c%2C (MTCY98.22c)%2C len: 354 aa. PPE39%2C Member of Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. near ORF P95249|Rv2356c|MTCY98.25 from Mycobacterium tuberculosis (615 aa)%2C FASTA scores: opt: 1566%2C E(): 3.2e-69%2C (66.1%25 identity in 349 aa overlap)%3B Q10778|MTCY48.17%2C Q10540|MTCY31.06c%2C E241779|MTCY98%2CQ10813|MTCY274.23c%2C P71868|MTCY03C7.23%2CP71869|MTCY03C7.24c%2C P42611|MTV037.06C%2C E64997|MTCY98%2CQ10707|MTCY49.38C%2C P71657|MTCY02B10.25c%2C etc. Note that the ATG and RBS appear to be provided by the IR of neighbouring IS6110. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=PPE39;locus_tag=Rv2353c;product=PPE family protein PPE39;protein_id=CCP45141.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2635577	2636931	.	+	.	ID=id-AL123456.3:2635577..2636931;Note=IS6110-8%2C len: 1355 nt. Insertion sequence IS6110 element that appears to have inserted in 5'-end of MTCY98.031c but is not flanked by expected 3 bp direct repeats of target sequence.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-8
AL123456.3	EMBL	repeat_region	2635577	2635604	.	+	.	ID=id-AL123456.3:2635577..2635604;Note=28 bp Inverted repeat%2C TGAACCGCCCCGGCATGTCCGGAGACTC%2Cat the left end of IS6110;gbkey=repeat_region
AL123456.3	EMBL	gene	2635628	2635954	.	+	.	ID=gene-Rv2354;Name=Rv2354;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2354
AL123456.3	EMBL	CDS	2635628	2635954	.	+	0	ID=cds-CCP45142.1;Parent=gene-Rv2354;Dbxref=EnsemblGenomes-Gn:Rv2354,EnsemblGenomes-Tr:CCP45142,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP45142.1;Name=CCP45142.1;Note=Rv2354%2C (MTCY98.23)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2354 and Rv2355%2Cthe sequence UUUUAAAG (directly upstream of Rv2355) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv2354;product=Probable transposase for insertion sequence element IS6110 (fragment);protein_id=CCP45142.1;transl_table=11
AL123456.3	EMBL	gene	2635903	2636889	.	+	.	ID=gene-Rv2355;Name=Rv2355;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2355;partial=true;start_range=.,2635903
AL123456.3	EMBL	CDS	2635903	2636889	.	+	0	ID=cds-CCP45143.1;Parent=gene-Rv2355;Dbxref=EnsemblGenomes-Gn:Rv2355,EnsemblGenomes-Tr:CCP45143,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP45143.1;Name=CCP45143.1;Note=Rv2355%2C (MTCY98.24)%2C len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2354 and Rv2355%2C the sequence UUUUAAAG (directly upstream of Rv2355) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 16 aa).;gbkey=CDS;locus_tag=Rv2355;partial=true;product=Probable transposase;protein_id=CCP45143.1;start_range=.,2635903;transl_table=11
AL123456.3	EMBL	repeat_region	2636904	2636931	.	-	.	ID=id-AL123456.3:2636904..2636931;Note=28 bp Inverted repeat%2C TGAACCGCCCCGGTGAGTCCGGAGACTC%2Cat the right end of IS6110;gbkey=repeat_region
AL123456.3	EMBL	gene	2637688	2639535	.	-	.	ID=gene-Rv2356c;Name=PPE40;gbkey=Gene;gene=PPE40;gene_biotype=protein_coding;locus_tag=Rv2356c
AL123456.3	EMBL	CDS	2637688	2639535	.	-	0	ID=cds-CCP45144.1;Parent=gene-Rv2356c;Dbxref=EnsemblGenomes-Gn:Rv2356c,EnsemblGenomes-Tr:CCP45144,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP45144.1;Name=CCP45144.1;Note=Rv2356c%2C (MTCY98.25)%2C len: 615 aa. PPE40%2C Member of Mycobacterium tuberculosis PPE_family%2C highly similar to others e.g. Q10778|MTCY48.17|YF48_MYCTU hypothetical PPE-family protein (678 aa)%2C FASTA scores: opt: 1888%2C E(): 1.9e-78%2C (54.4%25 identity in 667 aa overlap)%3B Q10540|MTCY31.06c%2C E241779|MTCY98%2C P42611|MTV037.06c%2CQ10813|MTCY274.23c%2C P71657|MTCY02B10.25c%2C MTCY03C7.23%2CP71869|MTCY03C7.24c%2C etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE40;locus_tag=Rv2356c;product=PPE family protein PPE40;protein_id=CCP45144.1;transl_table=11
AL123456.3	EMBL	gene	2639673	2641064	.	-	.	ID=gene-Rv2357c;Name=glyS;gbkey=Gene;gene=glyS;gene_biotype=protein_coding;locus_tag=Rv2357c
AL123456.3	EMBL	CDS	2639673	2641064	.	-	0	ID=cds-CCP45145.1;Parent=gene-Rv2357c;Dbxref=EnsemblGenomes-Gn:Rv2357c,EnsemblGenomes-Tr:CCP45145,GOA:P9WFV7,InterPro:IPR002314,InterPro:IPR002315,InterPro:IPR004154,InterPro:IPR006195,InterPro:IPR022961,InterPro:IPR027031,NCBI_GP:CCP45145.1;Name=CCP45145.1;Note=Rv2357c%2C (MTCY27.23%2C MTCY98.26)%2C len: 463 aa. Probable glyS%2C glycyl-tRNA synthetase%2C equivalent to Q9CCG4|GLYS|ML0826 putative glycyl-tRNA synthase from Mycobacterium leprae (463 aa)%2C FASTA scores: opt: 2898%2CE(): 1e-179%2C (90.2%25 identity in 459 aa overlap). Also highly similar to others e.g. Q9L2H9|SYG_STRCO|SCC121.07c from Streptomyces coelicolor (460 aa)%2C FASTA scores: opt: 2210%2C E(): 2.9e-135%2C (68.3%25 identity in 457 aa overlap)%3B Q9PPZ7|SYG_UREPA|GLYS|UU493 glycyl-tRNA synthetase from Ureaplasma parvum (Ureaplasma urealyticum biotype 1) (473 aa)%2C FASTA scores: opt: 1254%2C E(): 1.7e-73%2C (45.25%25 identity in 462 aa overlap)%3B P75425|SYG_MYCPN|GLYS|MPN354|MP482 glycyl-tRNA synthetase from Mycoplasma pneumoniae (449 aa)%2C FASTA scores: opt: 1074%2C E(): 6.9e-62%2C (39.45%25 identity in 454 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glyS;inference=protein motif:PROSITE:PS00179;locus_tag=Rv2357c;product=Probable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS);protein_id=CCP45145.1;transl_table=11
AL123456.3	EMBL	gene	2641246	2641653	.	+	.	ID=gene-Rv2358;Name=smtB;gbkey=Gene;gene=smtB;gene_biotype=protein_coding;locus_tag=Rv2358
AL123456.3	EMBL	CDS	2641246	2641653	.	+	0	ID=cds-CCP45146.1;Parent=gene-Rv2358;Dbxref=EnsemblGenomes-Gn:Rv2358,EnsemblGenomes-Tr:CCP45146,GOA:P9WMI5,InterPro:IPR001845,InterPro:IPR011991,NCBI_GP:CCP45146.1;Name=CCP45146.1;Note=Rv2358%2C (MTCY27.22c)%2C len: 135 aa. Probable smtB%2Ctranscriptional regulator%2C arsR family%2C equivalent to Q9CCG5|ML0825 putative ArsR-family transcriptional regulator from Mycobacterium leprae (140 aa)%2C FASTA scores: opt: 647%2C E(): 2e-34%2C (72.9%25 identity in 140 aa overlap). Also similar to others e.g. BAB48273|MLR0745 Transcriptional regulator from Rhizobium loti (Mesorhizobium loti) (104 aa)%2C FASTA scores: opt: 185%2C E(): 3.4e-05%2C (43.25%25 identity in 74 aa overlap) (has its N-terminus shorter)%3B P15905|ARR1_ECOLI arsenical resistance operon repressor from Escherichia coli (117 aa)%2C FASTA scores: opt: 164%2C E(): 8.1e-05%2C (39.1%25 identity in 69 aa overlap)%3B etc. Also similar to O53838|Rv0827|MTV043.19c putative transcriptional regulator from Mycobacterium tuberculosis (130 aa)%2C FASTA scores: opt: 201%2C E(): 4e-06%2C(35.7%25 identity in 98 aa overlap)%3B and O69711|Rv3744|MTV025.092 putative regulatory protein from Mycobacterium tuberculosis (120 aa)%2C FASTA scores: opt: 209%2C E(): 1.2e-06%2C (35.5 %25 identity in 93 aa overlap). Contains possible helix-turn-helix motif at aa 72-93 (Score 1103%2C +2.94 SD). Belongs to the ArsR family of transciptional regulators. Shown to bind palindromic DNA sequence upstream of Rv2358%3B inhibited by Zn2+ (See Canneva et al.%2C 2005).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=smtB;locus_tag=Rv2358;product=Probable transcriptional regulatory protein SmtB (probably ArsR-family);protein_id=CCP45146.1;transl_table=11
AL123456.3	EMBL	gene	2641650	2642042	.	+	.	ID=gene-Rv2359;Name=zur;gbkey=Gene;gene=zur;gene_biotype=protein_coding;gene_synonym=furB;locus_tag=Rv2359
AL123456.3	EMBL	CDS	2641650	2642042	.	+	0	ID=cds-CCP45147.1;Parent=gene-Rv2359;Dbxref=EnsemblGenomes-Gn:Rv2359,EnsemblGenomes-Tr:CCP45147,GOA:P9WN85,InterPro:IPR002481,InterPro:IPR011991,PDB:2O03,NCBI_GP:CCP45147.1;Name=CCP45147.1;Note=Rv2359%2C (MTCY27.21c)%2C len: 130 aa. Probable zur%2Czinc uptake regulation protein%2C equivalent to FURB|ML0824|Q9CCG6 putative ferric uptake regulatory protein from Mycobacterium leprae (131 aa)%2C FASTA scores: opt: 765%2C E(): 1.7e-43%2C (86.9%25 identity in 130 aa overlap). Also highly similar to ferric uptake regulation proteins e.g. Q9L2H5|SCC121.11 putative metal uptake regulation protein from Streptomyces coelicolor (139 aa)%2C FASTA scores: opt: 547%2C E(): 3.4e-29%2C (59.4%25 identity in 133 aa overlap)%3B P06975|FUR_ECOLI from Escherichia coli (148 aa)%2CFASTA scores: opt: 322%2C E(): 1.9e-14%2C (37.9%25 identity in 132 aa overlap)%3B P45599|FUR_KLEPN ferric uptake regulation protein from Klebsiella pneumoniae (155 aa)%2C FASTA scores: opt: 314%2C E(): 6.7e-14%2C (36.35%25 identity in 132 aa overlap)%3B etc. Belongs to the fur/ZUR family. Note that previously known as furB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=zur;locus_tag=Rv2359;product=Probable zinc uptake regulation protein Zur;protein_id=CCP45147.1;transl_table=11
AL123456.3	EMBL	gene	2642150	2642578	.	-	.	ID=gene-Rv2360c;Name=Rv2360c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2360c
AL123456.3	EMBL	CDS	2642150	2642578	.	-	0	ID=cds-CCP45148.1;Parent=gene-Rv2360c;Dbxref=EnsemblGenomes-Gn:Rv2360c,EnsemblGenomes-Tr:CCP45148,GOA:O05838,UniProtKB/TrEMBL:O05838,NCBI_GP:CCP45148.1;Name=CCP45148.1;Note=Rv2360c%2C (MTCY27.20)%2C len: 142 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2360c;product=Unknown protein;protein_id=CCP45148.1;transl_table=11
AL123456.3	EMBL	gene	2642578	2643468	.	-	.	ID=gene-Rv2361c;Name=Rv2361c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2361c
AL123456.3	EMBL	CDS	2642578	2643468	.	-	0	ID=cds-CCP45149.1;Parent=gene-Rv2361c;Dbxref=EnsemblGenomes-Gn:Rv2361c,EnsemblGenomes-Tr:CCP45149,GOA:P9WFF7,InterPro:IPR001441,InterPro:IPR018520,PDB:2VG2,PDB:2VG3,PDB:2VG4,PDB:4ONC,NCBI_GP:CCP45149.1;Name=CCP45149.1;Note=Rv2361c%2C (MT2430%2C MTCY27.19)%2C len: 296 aa. Long (C50) chain Z-isoprenyl diphosphate synthase (see citation below)%2C equivalent to UPPS_MYCLE|ML0634|B1937_F2_65|P38119 undecaprenyl pyrophosphate synthetase from Mycobacterium leprae (296 aa)%2C FASTA scores: opt: 1789%2C E(): 1.8e-97%2C(86.5%25 identity in 296 aa overlap). Also highly similar to others e.g. UPPS|Q9L2H4 undecaprenyl pyrophosphate synthetase from Streptomyces coelicolor (277 aa)%2C FASTA scores: opt: 1098%2C E(): 8.2e-60%2C (63.5%25 identity in 247 aa overlap)%3B Q55482|UPPS_SYNY3|SLL0506 from Synechocystis sp. strain PCC 6803 (249 aa)%2C FASTA scores: opt: 686%2C E(): 4.2e-33%2C (46.4%25 identity in 235 aa overlap)%3B O67291|UPPS_AQUAE|AQ_1248 from Aquifex aeolicus (231 aa)%2CFASTA scores: opt: 684%2C E(): 5.2e-33%2C (46.3%25 identity in 229 aa overlap)%3B etc. Also similar to Rv1086|MTV017.39 from Mycobacterium tuberculosis. Contains PS01066 Hypothetical YBR002c family signature. Seems to belong to the UPP synthetase family. Note that previously known as uppS.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01066;locus_tag=Rv2361c;product=Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase);protein_id=CCP45149.1;transl_table=11
AL123456.3	EMBL	gene	2643461	2644258	.	-	.	ID=gene-Rv2362c;Name=recO;gbkey=Gene;gene=recO;gene_biotype=protein_coding;locus_tag=Rv2362c
AL123456.3	EMBL	CDS	2643461	2644258	.	-	0	ID=cds-CCP45150.1;Parent=gene-Rv2362c;Dbxref=EnsemblGenomes-Gn:Rv2362c,EnsemblGenomes-Tr:CCP45150,GOA:P9WHI5,InterPro:IPR003717,InterPro:IPR012340,InterPro:IPR022572,NCBI_GP:CCP45150.1;Name=CCP45150.1;Note=Rv2362c%2C (MTCY27.18)%2C len: 265 aa. RecO%2C DNA repair protein%2C equivalent to Q9CCN0|ML0633 Mycobacterium leprae Hypothetical protein (268 aa)%2C FASTA scores: opt: 1560%2CE(): 8.5e-93%2C (86.6%25 identity in 268 aa overlap). Also highly similar to others e.g. Q9L2H3|SCC121.13c DNA repair protein recO from Streptomyces coelicolor (251 aa)%2C FASTA scores: opt: 843%2C E(): 6.9e-47%2C (52.2%25 identity in 249 aa overlap)%3B and similar to other hypothetical proteins. Weak similarity with P42095|RECO_BACSU DNA repair protein recombinase from Bacillus subtilis (255 aa)%2C FASTA scores: opt: 270%2C E(): 3.6e-10%2C (26.4%25 identity in 182 aa overlap). Maybe involved in modulating assembly and disassembly of RECA filaments (with RECF|Rv0003 and RECR|Rv3715c) (see citation below). Contains match to Pfam entry PF02565 Recombination protein O. Belongs to the RECO family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recO;locus_tag=Rv2362c;product=Possible DNA repair protein RecO;protein_id=CCP45150.1;transl_table=11
AL123456.3	EMBL	gene	2644320	2645774	.	+	.	ID=gene-Rv2363;Name=amiA2;gbkey=Gene;gene=amiA2;gene_biotype=protein_coding;locus_tag=Rv2363
AL123456.3	EMBL	CDS	2644320	2645774	.	+	0	ID=cds-CCP45151.1;Parent=gene-Rv2363;Dbxref=EnsemblGenomes-Gn:Rv2363,EnsemblGenomes-Tr:CCP45151,GOA:P9WQ99,InterPro:IPR000120,InterPro:IPR020556,InterPro:IPR023631,NCBI_GP:CCP45151.1;Name=CCP45151.1;Note=Rv2363%2C (MTCY27.17c)%2C len: 484 aa. Probable amiA2%2Camidase%2C highly similar or similar to others e.g. O28325|YJ54_ARCFU|AF1954 putative amidase from Archaeoglobus fulgidus (453 aa)%2C FASTA scores: opt: 777%2CE(): 1.1e-38%2C (35.0%25 identity in 474 aa overlap)%3B Q55424|AMID_SYNY3|SLL0828 putative amidase from Synechocystis sp. strain PCC 6803 (506 aa)%2C FASTA scores: opt: 770%2C E(): 3e-38%2C (36.4%25 identity in 456 aa overlap)%3B Q53116|AMDA enantiomerase-selective amidase from Rhodococcus sp. (462 aa)%2C FASTA scores: opt: 701%2C E(): 3.5e-34%2C (32.7%25 identity in 468 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. AMI2_MYCTU|AMIB2|Q11056|Rv1263|MT1301|MTCY50.19c|cy50.19c amidase (462 aa)%2C FASTA scores: opt: 1141%2C E(): 2.9e-60%2C(45.4%25 identity in 454 aa overlap)%3B etc. Contains PS00571 Amidases signature%2C and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the amidase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=amiA2;inference=protein motif:PROSITE:PS00571;locus_tag=Rv2363;product=Probable amidase AmiA2 (aminohydrolase);protein_id=CCP45151.1;transl_table=11
AL123456.3	EMBL	gene	2645771	2646673	.	-	.	ID=gene-Rv2364c;Name=era;gbkey=Gene;gene=era;gene_biotype=protein_coding;gene_synonym=bex;locus_tag=Rv2364c
AL123456.3	EMBL	CDS	2645771	2646673	.	-	0	ID=cds-CCP45152.1;Parent=gene-Rv2364c;Dbxref=EnsemblGenomes-Gn:Rv2364c,EnsemblGenomes-Tr:CCP45152,GOA:P9WNK9,InterPro:IPR004044,InterPro:IPR005225,InterPro:IPR005662,InterPro:IPR006073,InterPro:IPR009019,InterPro:IPR015946,InterPro:IPR027417,NCBI_GP:CCP45152.1;Name=CCP45152.1;Note=Rv2364c%2C (MT2433%2C MTCY27.16)%2C len: 300 aa. Probable era%2C GTP-binding protein%2C equivalent to Q49768|ERA_MYCLE|ML0631|B1937_F3_102 GTP-binding protein era homolog from Mycobacterium leprae (300 aa) FASTA scores: opt: 1589%2C E(): 3.4e-88%2C (81.4%25 identity in 301 aa overlap). Also highly similar to other GTP-binding proteins e.g. Q9RDF2|ERA_STRCO|SCC77.06 from Streptomyces coelicolor (317 aa)%2C FASTA scores: opt: 1264%2C E(): 1.1e-68%2C (64.0%25 identity in 306 aa overlap)%3B Q9KD52|ERA_BACHD|BH1367|BEX from Bacillus halodurans (304 aa)%2C FASTA scores: opt: 869%2C(44.8%25 identity in 297 aa overlap)%3B Q9KIH7|ERA_LACLA|ERAL from Lactococcus lactis (subsp. lactis) (Streptococcus lactis)%2C and Lactococcus lactis (subsp. cremoris) (Streptococcus cremoris) (303 aa)%2C FASTA scores: opt: 781%2CE(): 9.4e-40%2C (40.25%25 identity in 298 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the era/TRME family of GTP-binding proteins%2C era subfamily. Note that previously known as bex.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=era;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2364c;product=Probable GTP-binding protein Era;protein_id=CCP45152.1;transl_table=11
AL123456.3	EMBL	gene	2646747	2647088	.	-	.	ID=gene-Rv2365c;Name=Rv2365c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2365c
AL123456.3	EMBL	CDS	2646747	2647088	.	-	0	ID=cds-CCP45153.1;Parent=gene-Rv2365c;Dbxref=EnsemblGenomes-Gn:Rv2365c,EnsemblGenomes-Tr:CCP45153,GOA:O05833,InterPro:IPR016193,UniProtKB/TrEMBL:O05833,NCBI_GP:CCP45153.1;Name=CCP45153.1;Note=Rv2365c%2C (MTCY27.15)%2C len: 113 aa. Conserved hypothetical protein%2C highly similar to Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein from Mycobacterium leprae (108 aa)%2C FASTA scores: opt: 426%2CE(): 1.4e-18%2C (67.9%25 identity in 106 aa overlap). Also highly similar to Q9RDF3|SCC77.05 from Streptomyces coelicolor (132 aa)%2C FASTA scores: opt: 254%2C E(): 1.9e-18%2C(53.1%25 identity in 96 aa overlap). Equivalent to AAK46728 from Mycobacterium tuberculosis strain CDC1551 (93 aa) but longer 20 aa.;gbkey=CDS;locus_tag=Rv2365c;product=Conserved hypothetical protein;protein_id=CCP45153.1;transl_table=11
AL123456.3	EMBL	gene	2647060	2648367	.	-	.	ID=gene-Rv2366c;Name=Rv2366c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2366c
AL123456.3	EMBL	CDS	2647060	2648367	.	-	0	ID=cds-CCP45154.1;Parent=gene-Rv2366c;Dbxref=EnsemblGenomes-Gn:Rv2366c,EnsemblGenomes-Tr:CCP45154,GOA:P9WFP1,InterPro:IPR000644,InterPro:IPR002550,InterPro:IPR005170,InterPro:IPR016166,InterPro:IPR016169,NCBI_GP:CCP45154.1;Name=CCP45154.1;Note=Rv2366c%2C (MTCY27.14)%2C len: 435 aa. Probable conserved transmembrane protein%2C highly similar to Q9L2L3|SCC117.07 putative membrane protein from Streptomyces coelicolor (358 aa)%2C FASTA scores: opt: 1159%2CE(): 5.5e-64%2C (53.0%25 identity in 353 aa overlap)%3B ans similar to hypothetical proteins and hemolysin-related proteins e.g. Q9HN02|HLP|VNG2308G hemolysin protein from Halobacterium sp. strain NRC-1 (457 aa)%2C FASTA scores: opt: 623%2C E(): 6.2e-31%2C (28.4%25 identity in 433 aa overlap)%3B etc. Potential transmembrane protein with 2 CBS domains. Belongs to the UPF0053 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2366c;product=Probable conserved transmembrane protein;protein_id=CCP45154.1;transl_table=11
AL123456.3	EMBL	gene	2648364	2648912	.	-	.	ID=gene-Rv2367c;Name=Rv2367c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2367c
AL123456.3	EMBL	CDS	2648364	2648912	.	-	0	ID=cds-CCP45155.1;Parent=gene-Rv2367c;Dbxref=EnsemblGenomes-Gn:Rv2367c,EnsemblGenomes-Tr:CCP45155,GOA:P9WGX9,InterPro:IPR002036,InterPro:IPR020549,InterPro:IPR023091,NCBI_GP:CCP45155.1;Name=CCP45155.1;Note=Rv2367c%2C (MTCY27.13)%2C len: 182 aa. Conserved hypothetical protein%2C equivalent to Q49752|YN67_MYCLE|ML0628|B1937_F1_21 hypothetical 19.8 KDA protein from Mycobacterium leprae (178 aa)%2C FASTA scores: opt: 1051%2C E(): 2e-59%2C (89.1%25 identity in 175 aa overlap). Also highly similar to others e.g. Q9L2L4|SCC117.06 conserved hypothetical protein from Streptomyces coelicolor (165 aa)%2C FASTA scores: opt: 599%2C E(): 6e-31%2C (56.5%25 identity in 154 aa overlap)%3B Q9KD56|BH1363 hypothetical protein from Bacillus halodurans (159 aa)%2C FASTA scores: opt: 311%2C E(): 8.3e-13%2C (45.05%25 identity in 111 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2367c;product=Conserved hypothetical protein;protein_id=CCP45155.1;transl_table=11
AL123456.3	EMBL	gene	2648916	2649974	.	-	.	ID=gene-Rv2368c;Name=phoH1;gbkey=Gene;gene=phoH1;gene_biotype=protein_coding;gene_synonym=phoH;locus_tag=Rv2368c
AL123456.3	EMBL	CDS	2648916	2649974	.	-	0	ID=cds-CCP45156.1;Parent=gene-Rv2368c;Dbxref=EnsemblGenomes-Gn:Rv2368c,EnsemblGenomes-Tr:CCP45156,GOA:P9WIA3,InterPro:IPR003714,InterPro:IPR004087,InterPro:IPR004088,InterPro:IPR027417,NCBI_GP:CCP45156.1;Name=CCP45156.1;Note=Rv2368c%2C (MTCY27.12)%2C len: 352 aa. Probable phoH1%2CphoH-like protein (phosphate starvation-induced protein)%2Cprobably ATP-binding protein%2C equivalent to Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-like protein from Mycobacterium leprae (349 aa)%2C FASTA scores: opt: 1952%2C E(): 4.7e-107%2C (88.9%25 identity in 352 aa overlap). Also highly similar to Q9L2L5|SCC117.05 PHOH-like protein from Streptomyces coelicolor (359 aa)%2C FASTA scores: opt: 1407%2C E(): 3.6e-75%2C (63.6%25 identity in 349 aa overlap)%3B Q9RSY1|DR1988 PHOH-related protein from Deinococcus radiodurans (380 aa)%2C FASTA scores: opt: 1053%2C E(): 1.9e-54%2C (53.3%25 identity in 349 aa overlap)%3B Q9KD58|PHOH|BH1361 phosphate starvation-induced protein from Bacillus halodurans (320 aa)%2C FASTA scores: opt: 1019%2CE(): 1.6e-52%2C (54.35%25 identity in 300 aa overlap)%3B P46343|PHOL_BACSU PHOH-like protein from Bacillus subtilis (319 aa)%2C FASTA scores: opt: 1014%2C E(): 3.2e-52%2C (50.8%25 identity in 303 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the PHOH family. Note that previously known as phoH.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=phoH1;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2368c;product=Probable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH);protein_id=CCP45156.1;transl_table=11
AL123456.3	EMBL	gene	2649946	2650248	.	-	.	ID=gene-Rv2369c;Name=Rv2369c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2369c
AL123456.3	EMBL	CDS	2649946	2650248	.	-	0	ID=cds-CCP45157.1;Parent=gene-Rv2369c;Dbxref=EnsemblGenomes-Gn:Rv2369c,EnsemblGenomes-Tr:CCP45157,UniProtKB/TrEMBL:L0TC46,NCBI_GP:CCP45157.1;Name=CCP45157.1;Note=Rv2369c%2C (MTCY27.11)%2C len: 100 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2369c;product=Hypothetical protein;protein_id=CCP45157.1;transl_table=11
AL123456.3	EMBL	gene	2650245	2651558	.	-	.	ID=gene-Rv2370c;Name=Rv2370c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2370c
AL123456.3	EMBL	CDS	2650245	2651558	.	-	0	ID=cds-CCP45158.1;Parent=gene-Rv2370c;Dbxref=EnsemblGenomes-Gn:Rv2370c,EnsemblGenomes-Tr:CCP45158,InterPro:IPR025736,UniProtKB/TrEMBL:O05828,NCBI_GP:CCP45158.1;Name=CCP45158.1;Note=Rv2370c%2C (MTCY27.10)%2C len: 437 aa. Conserved hypothetical protein%2C member of family proteins from Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807 conserved hypothetical protein from Mycobacterium tuberculosis (432 aa)%2C FASTA scores: opt: 1943%2C E(): 9.4e-115%2C (69.9%25 identity in 409 aa overlap)%3B Rv1194c|MTCI364.06c%3B etc. Also similar to AAK45764|MT1500 conserved hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (432 aa)%2C FASTA scores: opt: 1934%2C E(): 9.4e-115%2C (69.9%25 identity in 409 aa overlap).;gbkey=CDS;locus_tag=Rv2370c;product=Conserved hypothetical protein;protein_id=CCP45158.1;transl_table=11
AL123456.3	EMBL	gene	2651753	2651938	.	+	.	ID=gene-Rv2371;Name=PE_PGRS40;gbkey=Gene;gene=PE_PGRS40;gene_biotype=protein_coding;locus_tag=Rv2371
AL123456.3	EMBL	CDS	2651753	2651938	.	+	0	ID=cds-CCP45159.1;Parent=gene-Rv2371;Dbxref=EnsemblGenomes-Gn:Rv2371,EnsemblGenomes-Tr:CCP45159,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FE9,NCBI_GP:CCP45159.1;Name=CCP45159.1;Note=Rv2371%2C (MTCY27.09c)%2C len: 61 aa. PE_PGRS40%2C Short protein%2C member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to N-terminal part of others e.g. AAK44356|MT0132 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (561 aa)%2C FASTA scores: opt: 217%2C E(): 4.9e-08%2C (69.65%25 identity in 56 aa overlap)%3B etc.;gbkey=CDS;gene=PE_PGRS40;locus_tag=Rv2371;product=PE-PGRS family protein PE_PGRS40;protein_id=CCP45159.1;transl_table=11
AL123456.3	EMBL	gene	2652037	2652825	.	-	.	ID=gene-Rv2372c;Name=Rv2372c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2372c
AL123456.3	EMBL	CDS	2652037	2652825	.	-	0	ID=cds-CCP45160.1;Parent=gene-Rv2372c;Dbxref=EnsemblGenomes-Gn:Rv2372c,EnsemblGenomes-Tr:CCP45160,GOA:P9WGX1,InterPro:IPR006700,InterPro:IPR015947,InterPro:IPR029026,InterPro:IPR029028,PDB:4L69,NCBI_GP:CCP45160.1;Name=CCP45160.1;Note=Rv2372c%2C (MTCY27.08)%2C len: 262 aa. Conserved hypothetical protein%2C equivalent to Q9CCN1|ML0626 hypothetical protein from Mycobacterium leprae (257 aa)%2CFASTA scores: opt: 1277%2C E(): 3e-71%2C (77.25%25 identity in 255 aa overlap). Also highly similar to others e.g. Q9RDD9|SDRD hypothetical 26.1 KDA protein from Streptomyces coelicolor (249 aa)%2C FASTA scores: opt: 624%2C E(): 3.2e-31%2C(45.05%25 identity in 253 aa overlap)%3B P54461|YQEU_BACSU hypothetical 28.8 kDa protein from Bacillus subtilis (256 aa)%2C FASTA scores: opt: 375%2C E(): 6e-16%2C (32.5%25 identity in 234 aa overlap)%3B etc. C-terminal half highly similar to Q49763|B1937_F2_57 from Mycobacterium leprae (128 aa)%2CFASTA scores: opt: 577%2C E(): 1.4e-28%2C (75.8%25 identity in 124 aa overlap). Belongs to the UPF0088 family.;gbkey=CDS;locus_tag=Rv2372c;product=Conserved hypothetical protein;protein_id=CCP45160.1;transl_table=11
AL123456.3	EMBL	gene	2652839	2653987	.	-	.	ID=gene-Rv2373c;Name=dnaJ2;gbkey=Gene;gene=dnaJ2;gene_biotype=protein_coding;locus_tag=Rv2373c
AL123456.3	EMBL	CDS	2652839	2653987	.	-	0	ID=cds-CCP45161.1;Parent=gene-Rv2373c;Dbxref=EnsemblGenomes-Gn:Rv2373c,EnsemblGenomes-Tr:CCP45161,GOA:P9WNV7,InterPro:IPR001305,InterPro:IPR001623,InterPro:IPR002939,InterPro:IPR008971,InterPro:IPR012724,NCBI_GP:CCP45161.1;Name=CCP45161.1;Note=Rv2373c%2C (MTCY27.07)%2C len: 382 aa. Probable dnaJ2%2Cchaperone protein%2C equivalent to Q49762|DNJ2_MYCLE|ML0625|B1937_F2_56 chaperone protein from Mycobacterium leprae (378 aa)%2C FASTA scores: opt: 2301%2CE(): 1.7e-120%2C (87.5%25 identity in 382 aa overlap). Also highly similar to other chaperone proteins DNAJ/DNAJ2 e.g. Q9RDD7|DNJ2_STRCO|SCC77.21c from Streptomyces coelicolor (378 aa)%2C FASTA scores: opt: 1456%2C E(): 1.2e-73%2C (54.8%25 identity in 385 aa overlap)%3B O52164|DNJ2_STRAL from Streptomyces albus (379 aa) FASTA scores: opt: 1378%2C E(): 2.6e-69%2C (52.2%25 identity in 385 aa overlap)%3B Q9S5A3|DNAJ_LISMO from Listeria monocytogenes (377 aa)%2CFASTA scores: opt: 1013%2C E(): 4.6e-49%2C (41.3%25 identity in 385 aa overlap)%3B etc. Also similar to Rv0352|MTCY13E10.12 from Mycobacterium tuberculosis. Contains 1 J domain and 1 cr domain. Belongs to the DNAJ family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaJ2;locus_tag=Rv2373c;product=Probable chaperone protein DnaJ2;protein_id=CCP45161.1;transl_table=11
AL123456.3	EMBL	gene	2654062	2655093	.	-	.	ID=gene-Rv2374c;Name=hrcA;gbkey=Gene;gene=hrcA;gene_biotype=protein_coding;locus_tag=Rv2374c
AL123456.3	EMBL	CDS	2654062	2655093	.	-	0	ID=cds-CCP45162.1;Parent=gene-Rv2374c;Dbxref=EnsemblGenomes-Gn:Rv2374c,EnsemblGenomes-Tr:CCP45162,GOA:P9WMK3,InterPro:IPR002571,InterPro:IPR011991,InterPro:IPR021153,InterPro:IPR029016,NCBI_GP:CCP45162.1;Name=CCP45162.1;Note=Rv2374c%2C (MTCY27.06)%2C len: 343 aa. Probable hrcA%2Cheat-inducible transcriptional repressor (see citation below)%2C equivalent to Q9CCN2|HRCA|ML0624 putative heat-inducible transcriptional regulator from Mycobacterium leprae (343 aa)%2C FASTA scores: opt: 1926%2C E(): 3.9e-107%2C(89.8%25 identity in 343 aa overlap). Also highly similar to other heat-inducible transcription repressor proteins e.g. Q9RDD6|HRCA|SCC77.22c from Streptomyces coelicolor (338 aa)%2C FASTA scores: opt: 1227%2C E(): 1.1e-65%2C (58.8%25 identity in 335 aa overlap)%3B O52163|HRCA_STRAL from Streptomyces albus (338 aa)%2C FASTA scores: opt: 1196%2C E(): 7.7e-64%2C(56.1%25 identity in 335 aa overlap)%3B P25499|HRCA_BACSU heat-inducible transcription repressor from Bacillus subtilis (343 aa)%2C FASTA scores: opt: 538%2C E(): 8.4e-25%2C(28.9%25 identity in 325 aa overlap)%3B etc. Almost identical%2Cbut conflict at C-terminus%2C to Q49749|YGRP|B1937_F1_18 putative heat-inducible transcription repressor from Mycobacterium leprae (197 aa) FASTA scores: opt: 1126%2C E(): 6.9e-60%2C (91.8%25 identity in 195 aa overlap). Belongs to the HRCA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hrcA;locus_tag=Rv2374c;product=Probable heat shock protein transcriptional repressor HrcA;protein_id=CCP45162.1;transl_table=11
AL123456.3	EMBL	gene	2655265	2655582	.	+	.	ID=gene-Rv2375;Name=Rv2375;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2375
AL123456.3	EMBL	CDS	2655265	2655582	.	+	0	ID=cds-CCP45163.1;Parent=gene-Rv2375;Dbxref=EnsemblGenomes-Gn:Rv2375,EnsemblGenomes-Tr:CCP45163,InterPro:IPR014447,UniProtKB/TrEMBL:O05823,NCBI_GP:CCP45163.1;Name=CCP45163.1;Note=Rv2375%2C (MTCY27.05c)%2C len: 105 aa. Conserved hypothetical protein%2C highly similar to only CAC32314|2SCD60.09c conserved hypothetical protein from Streptomyces coelicolor (98 aa)%2C FASTA scores: opt: 425%2CE(): 5.7e-24%2C (63.25%25 identity in 98 aa overlap).;gbkey=CDS;locus_tag=Rv2375;product=Conserved hypothetical protein;protein_id=CCP45163.1;transl_table=11
AL123456.3	EMBL	gene	2655609	2656115	.	-	.	ID=gene-Rv2376c;Name=cfp2;gbkey=Gene;gene=cfp2;gene_biotype=protein_coding;gene_synonym=mtb12;locus_tag=Rv2376c
AL123456.3	EMBL	CDS	2655609	2656115	.	-	0	ID=cds-CCP45164.1;Parent=gene-Rv2376c;Dbxref=EnsemblGenomes-Gn:Rv2376c,EnsemblGenomes-Tr:CCP45164,GOA:P9WIN7,InterPro:IPR020235,NCBI_GP:CCP45164.1;Name=CCP45164.1;Note=Rv2376c%2C (MT2445%2C MTCY27.04)%2C len: 168 aa. Cfp2 (alternate gene name: mtb12)%2C low molecular weight antigen%2Csecreted protein similar to Q49771|MB12_MYCLE|ML0620|B1937_F3_91 low molecular weight antigen MTB12 homolog precursor from Mycobacterium leprae (167 aa)%2C FASTA scores: opt: 682%2C E(): 1.7e-32%2C (65.5%25 identity in 165 aa overlap). Belongs to the MTB12 family. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cfp2;locus_tag=Rv2376c;product=Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2);protein_id=CCP45164.1;transl_table=11
AL123456.3	EMBL	gene	2656215	2656430	.	-	.	ID=gene-Rv2377c;Name=mbtH;gbkey=Gene;gene=mbtH;gene_biotype=protein_coding;locus_tag=Rv2377c
AL123456.3	EMBL	CDS	2656215	2656430	.	-	0	ID=cds-CCP45165.1;Parent=gene-Rv2377c;Dbxref=EnsemblGenomes-Gn:Rv2377c,EnsemblGenomes-Tr:CCP45165,InterPro:IPR005153,PDB:2KHR,NCBI_GP:CCP45165.1;Name=CCP45165.1;Note=Rv2377c%2C (MT2445.1%2C MTCY27.03)%2C len: 71 aa. Putative mbtH%2C conserved protein with no function assigned (see Quadri et al.%2C 1998%3B De Voss et al.%2C 1999)%2C similar to hypothetical proteins or proteins found in several gene clusters for biosynthesis or transport of siderophores and other nonribosomally synthesized peptides e.g. Q9Z388|SCE8.11c putative small conserved hypothetical protein from Streptomyces coelicolor (71 aa)%2C FASTA scores: opt: 345%2C E(): 1.4e-19%2C (68.2%25 identity in 66 aa overlap)%3B Q9F8V3|CUMB COUY protein (probably involved in the biosynthesis of aminocoumarin antibiotic coumermycin a(1)) (see Wang et al.%2C 2000) from Streptomyces rishiriensis (71 aa)%2C FASTA scores: opt: 329%2C E(): 2.2e-18%2C (63.2%25 identity in 68 aa overlap)%3B Q9F5J2|SIM-CB MBTH-like protein (probably protein involved in the biosynthesis of aminocoumarin antibiotic coumermycin a(1)) from Streptomyces antibioticus (70 aa)%2C FASTA scores: opt: 308%2CE(): 8.4e-17%2C (65.6%25 identity in 64 aa overlap)%3B Q9FB14 MBTH-like protein (involved in the biosynthesis of the antitumor drug bleomycin) (see Du et al.%2C 2000) from Streptomyces verticillus FASTA scores: opt: 220%2C E(): 8.8e-10%2C (41.2%25 identity in 68 aa overlap)%3B etc.;gbkey=CDS;gene=mbtH;locus_tag=Rv2377c;product=Putative conserved protein MbtH;protein_id=CCP45165.1;transl_table=11
AL123456.3	EMBL	gene	2656408	2657703	.	-	.	ID=gene-Rv2378c;Name=mbtG;gbkey=Gene;gene=mbtG;gene_biotype=protein_coding;locus_tag=Rv2378c
AL123456.3	EMBL	CDS	2656408	2657703	.	-	0	ID=cds-CCP45166.1;Parent=gene-Rv2378c;Dbxref=EnsemblGenomes-Gn:Rv2378c,EnsemblGenomes-Tr:CCP45166,GOA:P9WKF7,NCBI_GP:CCP45166.1;Name=CCP45166.1;Note=Rv2378c%2C (MTCY27.02)%2C len: 431 aa. MbtG%2Clysine-N-oxygenase (hydroxylase) (EC 1.13.12.10 or 1.14.13.59%3B depending if enzyme is NADPH dependent or independent) (see citations below)%2C showing some similarity with various proteins including ornithine and lysine-N-oxygenases%2C e.g. Q9K6Q1|TRKA|BH3677 potassium uptake protein from Bacillus halodurans (350 aa)%2C FASTA scores: opt: 153%2C E(): 0.016%2C (25.2%25 identity in 246 aa overlap)%3B P56584|SID1_USTMA L-ornithine 5-monooxygenase from Ustilago maydis (Smut fungus) (570 aa)%2C FASTA scores: opt: 136%2C E(): 0.31%2C (22.85%25 identity in 127 aa overlap)%3B Q9HHV0|HXYA|VNG6214G monooxygenase from Halobacterium sp. strain NRC-1 (477 aa)%2C FASTA scores: opt: 119%2C E(): 3.4%2C(40.0%25 identity in 70 aa overlap)%3B O69828|SC1A6.23 putative lysine N-hydroxlase (fragment) from Streptomyces coelicolor (134 aa)%2C blast score: 76 (similarity in part for this one)%3B etc. Cofactors: FAD (by similarity).;gbkey=CDS;gene=mbtG;locus_tag=Rv2378c;product=Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase);protein_id=CCP45166.1;transl_table=11
AL123456.3	EMBL	gene	2657700	2662085	.	-	.	ID=gene-Rv2379c;Name=mbtF;gbkey=Gene;gene=mbtF;gene_biotype=protein_coding;locus_tag=Rv2379c
AL123456.3	EMBL	CDS	2657700	2662085	.	-	0	ID=cds-CCP45167.1;Parent=gene-Rv2379c;Dbxref=EnsemblGenomes-Gn:Rv2379c,EnsemblGenomes-Tr:CCP45167,GOA:O05819,InterPro:IPR000873,InterPro:IPR001242,InterPro:IPR009081,InterPro:IPR010071,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:O05819,NCBI_GP:CCP45167.1;Name=CCP45167.1;Note=Rv2379c%2C (MTCY27.01)%2C len: 1461 aa. MbtF%2C peptide synthetase (see citations below)%2C similar in part to several synthases e.g. O52820|PCZA363.4 protein from Amycolatopsis orientalis (4077 aa)%2C FASTA scores: opt: 1873%2C E(): 1.1e-99%2C (35.55%25 identity in 1522 aa overlap)%3B O07944|SNBDE pristinamycin I synthase 3 and 4 from Streptomyces pristinaespiralis (4848 aa)%2C FASTA scores: opt: 1817%2C E(): 2.1e-96%2C (33.65%25 identity in 1463 aa overlap)%3B O52821 protein similar to peptide synthetase from Amycolatopsis orientalis (1860 aa) FASTA scores: opt: 1705%2CE(): 2.9e-90%2C (34.75%25 identity in 1344 aa overlap)%3B Q9XCF2|PSTB putative peptide synthetase (similar to Mycobacterium tuberculosis nrp protein) from Mycobacterium avium (2552 aa)%2C FASTA scores: opt: 1687%2C E(): 4e-89%2C(35.45%25 identity in 1058 aa overlap)%3B Q9ZET7 peptide synthetase (fragment) from Mycobacterium smegmatis (1438 aa)%2C FASTA scores: opt: 1479%2C E(): 2.5e-77%2C (30.45%25 identity in 1507 aa overlap)%3B etc. Contains PS00455 putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtF;inference=protein motif:PROSITE:PS00455;locus_tag=Rv2379c;product=Peptide synthetase MbtF (peptide synthase);protein_id=CCP45167.1;transl_table=11
AL123456.3	EMBL	gene	2662067	2667115	.	-	.	ID=gene-Rv2380c;Name=mbtE;gbkey=Gene;gene=mbtE;gene_biotype=protein_coding;locus_tag=Rv2380c
AL123456.3	EMBL	CDS	2662067	2667115	.	-	0	ID=cds-CCP45168.1;Parent=gene-Rv2380c;Dbxref=EnsemblGenomes-Gn:Rv2380c,EnsemblGenomes-Tr:CCP45168,GOA:I6Y0L1,InterPro:IPR000873,InterPro:IPR001242,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR010071,InterPro:IPR020845,InterPro:IPR025110,UniProtKB/TrEMBL:I6Y0L1,NCBI_GP:CCP45168.1;Name=CCP45168.1;Note=Rv2380c%2C (MTCY22H8.05)%2C len: 1682 aa. MbtE%2C peptide synthetase (see citations below)%2C similar in part to several synthases e.g. O07944|SNBDE pristinamycin I synthase 3 and 4 from Streptomyces pristinaespiralis (4848 aa)%2C FASTA scores: opt: 2635%2C E(): 1.9e-146%2C (36.8%25 identity in 1657 aa overlap)%3B O05647|SNBDE virginiamycin S synthetase (fragment) from Streptomyces virginiae (1997 aa) FASTA scores: opt: 2580%2C E(): 1.6e-143%2C (40.65%25 identity in 1163 aa overlap)%3B Q9R9I2|DHBF protein involved in siderophore production from Bacillus subtilis (2378 aa)%2CFASTA scores: opt: 2388%2C E(): 3.6e-132%2C (33.9%25 identity in 1579 aa overlap)%3B O68487|ACMB actinomycin synthetase II from Streptomyces chrysomallus (2611 aa)%2C FASTA scores: opt: 2165%2C E(): 4.9e-119%2C (35.0%25 identity in 1634 aa overlap)%3B etc. Equivalent to AAK46743 from Mycobacterium tuberculosis strain CDC1551 (1787 aa) but shorter 105 aa. Contains PS00455 putative AMP-binding domain signature%2C and PS00012 Phosphopantetheine attachment site. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtE;inference=protein motif:PROSITE:PS00455;locus_tag=Rv2380c;product=Peptide synthetase MbtE (peptide synthase);protein_id=CCP45168.1;transl_table=11
AL123456.3	EMBL	gene	2667255	2670269	.	-	.	ID=gene-Rv2381c;Name=mbtD;gbkey=Gene;gene=mbtD;gene_biotype=protein_coding;locus_tag=Rv2381c
AL123456.3	EMBL	CDS	2667255	2670269	.	-	0	ID=cds-CCP45169.1;Parent=gene-Rv2381c;Dbxref=EnsemblGenomes-Gn:Rv2381c,EnsemblGenomes-Tr:CCP45169,GOA:P71719,InterPro:IPR001227,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR013968,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016040,InterPro:IPR020801,UniProtKB/TrEMBL:P71719,NCBI_GP:CCP45169.1;Name=CCP45169.1;Note=Rv2381c%2C (MTCY22H8.04)%2C len: 1004 aa. MbtD%2Cpolyketide synthase (see citations below)%2C similar in part to several synthases e.g. Q03132|ERY2_SACER|ERYA erythronolide synthase%2C modules 3 and 4 from Saccharopolyspora erythraea (Streptomyces erythraeus) (3567 aa)%2C FASTA scores: opt: 971%2C E(): 1e-46%2C (29.35%25 identity in 1043 aa overlap)%3B Q9F829|megaii megalomicin 6-deoxyerythronolide B synthase 2 from Micromonospora megalomicea subsp. nigra (3562 aa)%2C FASTA scores: opt: 787%2CE(): 2.4e-36%2C (29.35%25 identity in 1032 aa overlap)%3B Q9L4W4|NYSB polyketide synthase from Streptomyces noursei (3192 aa)%2C FASTA scores: opt: 761%2C E(): 6.6e-35%2C (29.55%25 identity in 1086 aa overlap)%3B O30764|NIDA1 polyketide synthase modules 1 and 2 from Streptomyces caelestis (4340 aa)%2C FASTA scores: opt: 726%2C E(): 7.8e-33%2C (27.3%25 identity in 1052 aa overlap)%3B etc. Contains PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtD;inference=protein motif:PROSITE:PS00012;locus_tag=Rv2381c;product=Polyketide synthetase MbtD (polyketide synthase);protein_id=CCP45169.1;transl_table=11
AL123456.3	EMBL	gene	2670269	2671603	.	-	.	ID=gene-Rv2382c;Name=mbtC;gbkey=Gene;gene=mbtC;gene_biotype=protein_coding;locus_tag=Rv2382c
AL123456.3	EMBL	CDS	2670269	2671603	.	-	0	ID=cds-CCP45170.1;Parent=gene-Rv2382c;Dbxref=EnsemblGenomes-Gn:Rv2382c,EnsemblGenomes-Tr:CCP45170,GOA:P71718,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR016038,InterPro:IPR016039,UniProtKB/TrEMBL:P71718,NCBI_GP:CCP45170.1;Name=CCP45170.1;Note=Rv2382c%2C (MTCY22H8.03)%2C len: 444 aa. MbtC%2Cpolyketide synthase (see citations below)%2C similar in part to several synthases e.g. Q9F7T9 avermectin polyketide synthase (fragment) from Streptomyces avermitilis (3626 aa)%2C FASTA scores: opt: 1458%2C E(): 7e-82%2C (50.65%25 identity in 446 aa overlap)%3B AAG23264|SPNA polyketide synthase loading and extender module 1 from Saccharopolyspora spinosa (2595 aa) FASTA scores: opt: 1441%2C E(): 6e-81%2C(49.1%25 identity in 446 aa overlap)%3B O33954|TYLG tylactone synthase starter module and modules 1 %26 2 from Streptomyces fradiae (4472 aa) FASTA scores: opt: 1439%2C E(): 1.2e-80%2C(51.0%25 identity in 447 aa overlap)%3B O30764|NIDA1 polyketide synthase modules 1 and 2 from Streptomyces caelestis (4340 aa) FASTA scores: opt: 1432%2C E(): 3.3e-80%2C (50.9%25 identity in 442 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtC;locus_tag=Rv2382c;product=Polyketide synthetase MbtC (polyketide synthase);protein_id=CCP45170.1;transl_table=11
AL123456.3	EMBL	gene	2671593	2675837	.	-	.	ID=gene-Rv2383c;Name=mbtB;gbkey=Gene;gene=mbtB;gene_biotype=protein_coding;locus_tag=Rv2383c
AL123456.3	EMBL	CDS	2671593	2675837	.	-	0	ID=cds-CCP45171.1;Parent=gene-Rv2383c;Dbxref=EnsemblGenomes-Gn:Rv2383c,EnsemblGenomes-Tr:CCP45171,GOA:P9WQ63,InterPro:IPR000873,InterPro:IPR001031,InterPro:IPR001242,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR010071,InterPro:IPR013624,InterPro:IPR020845,InterPro:IPR025110,InterPro:IPR029058,NCBI_GP:CCP45171.1;Name=CCP45171.1;Note=Rv2383c%2C (MTCY22H8.02)%2C len: 1414 aa. MbtB%2Cphenyloxazoline synthase (see citations below)%2C similar to the N-terminal region of several synthetases e.g. Q9EWP5|SC4C2.17 putative non-ribosomal peptide synthase from Streptomyces coelicolor (2229 aa)%2C FASTA scores: opt: 2878%2C E(): 4.1e-156%2C (46.85%25 identity in 1138 aa overlap)%3B Q9Z399|IRP2 yersiniabactin biosynthetic from Yersinia pestis (2041 aa)%2C FASTA scores: opt: 2297%2C E(): 5.3e-123%2C(38.55%25 identity in 1069 aa overlap)%3B P48633|HMP2_YEREN|IRP2 high-molecular-weight protein 2 (may be involved in the nonribosomal synthesis of small peptides) from Yersinia enterocolitica (2035 aa)%2C FASTA scores: opt: 2275%2C E(): 9.4e-122%2C (38.45%25 identity in 1069 aa overlap)%3B O85739|PCHE|PA4226 dihydroaeruginoic acid synthetase from Pseudomonas aeruginosa (1438 aa) FASTA scores: opt: 2236%2C E(): 1.2e-119%2C (38.2%25 identity in 1330 aa overlap)%3B Q9RFM8|PCHE pyochelin synthetase from Pseudomonas aeruginosa (1438 aa)%2C FASTA scores: opt: 2229%2CE(): 3e-119%2C (38.0%25 identity in 1329 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature%2C and PS00012 Phosphopantetheine attachment site. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtB;inference=protein motif:PROSITE:PS00455;locus_tag=Rv2383c;product=Phenyloxazoline synthase MbtB (phenyloxazoline synthetase);protein_id=CCP45171.1;transl_table=11
AL123456.3	EMBL	gene	2675936	2677633	.	+	.	ID=gene-Rv2384;Name=mbtA;gbkey=Gene;gene=mbtA;gene_biotype=protein_coding;locus_tag=Rv2384
AL123456.3	EMBL	CDS	2675936	2677633	.	+	0	ID=cds-CCP45172.1;Parent=gene-Rv2384;Dbxref=EnsemblGenomes-Gn:Rv2384,EnsemblGenomes-Tr:CCP45172,GOA:P71716,InterPro:IPR000873,InterPro:IPR025110,UniProtKB/TrEMBL:P71716,NCBI_GP:CCP45172.1;Name=CCP45172.1;Note=Rv2384%2C (MTCY22H8.01%2C MTCY253.37c)%2C len: 565 aa. mbtA%2C bifunctional enzyme%2C including salicyl-AMP ligase (Sal-AMP ligase) and salicyl-S-ArCP synthetase (see Quadri et al.%2C 1998%3B De Voss et al.%2C 1999)%2C highly similar to other ligases e.g. Q9F638|MXCE from Stigmatella aurantiaca 2%2C3-DHBA-AMP ligase (protein involved in the biosynthesis of 2%2C3-dihydroxybenzoic acid%2C contains the AMP binding signature) (543 aa)%2C FASTA scores: opt: 1683%2C E(): 2.8e-90%2C(48.25%25 identity in 545 aa overlap) (see Silakowski et al.%2C2000)%3B P40871|DHBE_BACSU|ENTE 2%2C3-dihydroxybenzoate-AMP ligase from Bacillus subtilis (539 aa)%2C FASTA scores: opt: 1569%2C E(): 1.2e-83%2C (44.9%25 identity in 532 aa overlap)%3B O07899|VIBE_VIBCHVC0772 vibriobactin-specific 2%2C3-dihydroxybenzoate-AMP ligase from Vibrio cholerae (543 aa)%2C FASTA scores: opt: 1457%2C E(): 3.7e-77%2C (44.6%25 identity in 545 aa overlap)%3B etc. Also similar to P95819|SNBA pristinamycin I synthetase I from Streptomyces pristinaespiralis (582 aa)%2C FASTA scores: opt: 1532%2C E(): 1.7e-81%2C (46.35%25 identity in 548 aa overlap)%3B and Q9RFM9|PCHD salicyl-AMP ligase from Pseudomonas aeruginosa (547 aa)%2C FASTA scores: opt: 1415%2C E(): 1e-74%2C (45.95%25 identity in 533 aa overlap). Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtA;inference=protein motif:PROSITE:PS00455;locus_tag=Rv2384;product=Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase;protein_id=CCP45172.1;transl_table=11
AL123456.3	EMBL	gene	2677729	2678649	.	+	.	ID=gene-Rv2385;Name=mbtJ;gbkey=Gene;gene=mbtJ;gene_biotype=protein_coding;gene_synonym=lipK;locus_tag=Rv2385
AL123456.3	EMBL	CDS	2677729	2678649	.	+	0	ID=cds-CCP45173.1;Parent=gene-Rv2385;Dbxref=EnsemblGenomes-Gn:Rv2385,EnsemblGenomes-Tr:CCP45173,GOA:Q79FE8,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:Q79FE8,NCBI_GP:CCP45173.1;Name=CCP45173.1;Note=Rv2385%2C (MTCY253.36c)%2C len: 306 aa. Putative mbtJ%2Cacetyl hydrolase (see citations below)%2C showing some similarity with various hydrolases including acetyl hydrolases e.g. Q9ZBM4|MLCB1450.08|ML0314 putative hydrolase/esterase from Mycobacterium leprae (335 aa)%2CFASTA scores: opt: 449%2C E(): 6.7e-21%2C (33.85%25 identity in 313 aa overlap)%3B AAK47950|MT3591 Esterase from M. tuberculosis strain CDC1551 (327 aa)%2C FASTA scores: opt: 469%2C E(): 3.6e-22%2C (35%25 identity in 283 aa overlap)%3B Q9X8J4|SCE9.22 putative esterase from Streptomyces coelicolor (266 aa)%2C FASTA scores: opt: 430%2CE(): 8.5e-20%2C(38%25 identity in 245 aa overlap)%3B Q01109|BAH_STRHY acetyl-hydrolase from Streptomyces hygroscopicus (299 aa)%2CFASTA scores: opt: 420%2C E(): 4e-19%2C (35.1%25 identity in 265 aa overlap). Equivalent to AAK46748 from Mycobacterium tuberculosis strain CDC1551 (327 aa) but shorter 21 aa. Note that previously known as lipK.;gbkey=CDS;gene=mbtJ;locus_tag=Rv2385;product=Putative acetyl hydrolase MbtJ;protein_id=CCP45173.1;transl_table=11
AL123456.3	EMBL	gene	2678653	2680005	.	-	.	ID=gene-Rv2386c;Name=mbtI;gbkey=Gene;gene=mbtI;gene_biotype=protein_coding;gene_synonym=trpE2;locus_tag=Rv2386c
AL123456.3	EMBL	CDS	2678653	2680005	.	-	0	ID=cds-CCP45174.1;Parent=gene-Rv2386c;Dbxref=EnsemblGenomes-Gn:Rv2386c,EnsemblGenomes-Tr:CCP45174,GOA:P9WFX1,InterPro:IPR005801,InterPro:IPR015890,InterPro:IPR019996,InterPro:IPR019999,PDB:2G5F,PDB:2I6Y,PDB:3LOG,PDB:3RV6,PDB:3RV7,PDB:3RV8,PDB:3RV9,PDB:3ST6,PDB:3VEH,NCBI_GP:CCP45174.1;Name=CCP45174.1;Note=Rv2386c%2C (MTCY253.35)%2C len: 450 aa. mbtI%2Cisochorismate synthase (see citations below)%2C similar to Q9X9I8|IRP9 salicylate synthetase from Yersinia enterocolitica (434 aa)%2C FASTA scores: opt: 887%2C E(): 7.5e-48%2C (37.45%25 identity in 422 aa overlap)%3B and similar in C-terminal region to many anthranilate synthases component I e.g. Q9Z4W7|TRPE_STRCO|SCE8.07c from Streptomyces coelicolor (511 aa)%2C FASTA scores: opt: 509%2CE(): 3e-24%2C (40.4%25 identity in 255 aa overlap)%3B P33975|TRPE_HALVO from Halobacterium volcanii (Haloferax volcanii) (523 aa) FASTA scores: opt: 488%2C E(): 6.2e-23%2C(34.2%25 identity in 298 aa overlap)%3B and similar to Q08653|TRPE_THEMA|TM0142 anthranilate synthase component I from Thermotoga maritima (461 aa)%2C FASTA scores: opt: 478%2CE(): 2.3e-22%2C (28.4%25 identity in 440 aa overlap)%3B etc. Could be belong to the anthranilate synthase component I family. Note that previously known as trpE2%2C an anthranilate synthase component I.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mbtI;locus_tag=Rv2386c;product=Isochorismate synthase MbtI;protein_id=CCP45174.1;transl_table=11
AL123456.3	EMBL	gene	2680765	2682018	.	+	.	ID=gene-Rv2387;Name=Rv2387;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2387
AL123456.3	EMBL	CDS	2680765	2682018	.	+	0	ID=cds-CCP45175.1;Parent=gene-Rv2387;Dbxref=EnsemblGenomes-Gn:Rv2387,EnsemblGenomes-Tr:CCP45175,InterPro:IPR010293,UniProtKB/TrEMBL:P71757,NCBI_GP:CCP45175.1;Name=CCP45175.1;Note=Rv2387%2C (MTCY253.34c)%2C len: 417 aa. Conserved protein%2C showing some similarities with others e.g. Q9K663|BH3869 hypothetical protein from Bacillus halodurans (337 aa)%2C FASTA scores: opt: 343%2C E(): 4.8e-14%2C (29.0%25 identity in 400 aa overlap)%3B AAK25471|CC3509 hypothetical protein from Caulobacter crescentus (365 aa)%2C FASTA scores: opt: 282%2C E(): 3.2e-10%2C (32.6%25 identity in 399 aa overlap)%3B P73953|SLR1512 [D90911_21] conserved hypothetical protein from Synechocystis sp. strain PCC6803 (374 aa)%2C FASTA scores: opt: 230%2C E(): 5.5e-07%3B (24.75%25 identity in 408 aa overlap)%3B etc. Contains PS00213 Lipocalin signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00213;locus_tag=Rv2387;product=Conserved protein;protein_id=CCP45175.1;transl_table=11
AL123456.3	EMBL	gene	2682015	2683142	.	-	.	ID=gene-Rv2388c;Name=hemN;gbkey=Gene;gene=hemN;gene_biotype=protein_coding;locus_tag=Rv2388c
AL123456.3	EMBL	CDS	2682015	2683142	.	-	0	ID=cds-CCP45176.1;Parent=gene-Rv2388c;Dbxref=EnsemblGenomes-Gn:Rv2388c,EnsemblGenomes-Tr:CCP45176,GOA:P9WP73,InterPro:IPR004559,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR023404,NCBI_GP:CCP45176.1;Name=CCP45176.1;Note=Rv2388c%2C (MTCY253.33)%2C len: 375 aa. Probable hemN%2Coxygen-independent coproporphyrinogen III oxidases%2C highly similar to many putative oxygen-independent coproporphyrinogen III oxidases e.g. Q9RDD2|SCC77.26 from Streptomyces coelicolor (435 aa)%2C FASTA scores: opt: 1358%2CE(): 1.5e-76%2C (56.55%25 identity in 382 aa overlap)%3B BAB51237|MLR4627 from Rhizobium loti (Mesorhizobium loti) (392 aa)%2C FASTA scores: opt: 696%2C E(): 1.1e-35%2C (36.8%25 identity in 383 aa overlap)%3B Q9KUR0|VC0455 from Vibrio cholerae (391 aa)%2C FASTA scores: opt: 691%2C 2.2e-35%2C (32.65%25 identity in 386 aa overlap)%3B P54304|HEMN_BACSU from Bacillus subtilis (366 aa)%2C FASTA scores: opt: 668 %2C E(): 5.6e-34%3B (34.9%25 identity in 327 aa overlap)%3B etc. Equivalent to AAK46752 from Mycobacterium tuberculosis strain CDC1551 (390 aa) but shorter 375 aa. Belongs to the anaerobic coproporphyrinogen III oxidase family.;gbkey=CDS;gene=hemN;locus_tag=Rv2388c;product=Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase);protein_id=CCP45176.1;transl_table=11
AL123456.3	EMBL	gene	2683248	2683712	.	-	.	ID=gene-Rv2389c;Name=rpfD;gbkey=Gene;gene=rpfD;gene_biotype=protein_coding;locus_tag=Rv2389c
AL123456.3	EMBL	CDS	2683248	2683712	.	-	0	ID=cds-CCP45177.1;Parent=gene-Rv2389c;Dbxref=EnsemblGenomes-Gn:Rv2389c,EnsemblGenomes-Tr:CCP45177,GOA:P9WG27,InterPro:IPR010618,InterPro:IPR023346,NCBI_GP:CCP45177.1;Name=CCP45177.1;Note=Rv2389c%2C (MTCY253.32)%2C len: 154 aa. Probable rpfD%2Cresuscitation-promoting factor. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citation below). Similar to others from Mycobacterium tuberculosis e.g. O07747|Rv1884c|MTCY180.34|RPFC probable resuscitation-promoting factor from Mycobacterium tuberculosis (176 aa)%2C FASTA scores: opt: 382%2C E(): 2.3e-17%2C (55.45%25 identity in 101 aa overlap)%3B etc. Also similarity with Q9CBF8|ML2030 hypothetical protein from Mycobacterium leprae (157 aa)%2C FASTA scores: opt: 397%2C E(): 2.4e-18%2C (47.95%25 identity in 121 aa overlap)%3B Q9F2Q2|SCE41.06c putative secreted protein from Streptomyces coelicolor (244 aa)%2C FASTA scores: opt: 341%2CE(): 1.1e-14%2C (40.45%25 identity in 131 aa overlap)%3B and O86308|Z96935|MLRPF_1 RPF protein precursor from Micrococcus luteus (220 aa)%2C FASTA scores: opt: 301%2C E(): 3.6e-12%2C (39.4%25 identity in 132 aa overlap). Contains a secretory signal sequence in N-terminus. Supposed acts at very low concentration. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;gbkey=CDS;gene=rpfD;locus_tag=Rv2389c;product=Probable resuscitation-promoting factor RpfD;protein_id=CCP45177.1;transl_table=11
AL123456.3	EMBL	gene	2683709	2684266	.	-	.	ID=gene-Rv2390c;Name=Rv2390c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2390c
AL123456.3	EMBL	CDS	2683709	2684266	.	-	0	ID=cds-CCP45178.1;Parent=gene-Rv2390c;Dbxref=EnsemblGenomes-Gn:Rv2390c,EnsemblGenomes-Tr:CCP45178,GOA:P71754,UniProtKB/TrEMBL:P71754,NCBI_GP:CCP45178.1;Name=CCP45178.1;Note=Rv2390c%2C (MTCY253.31)%2C len: 185 aa. Conserved hypothetical protein%2C similar to other Mycobacterium tuberculosis proteins Q11032|YD62_MYCTU|MTCY02B10.26c|Rv1362c hypothetical 23.5 kDa protein (220 aa)%2C FASTA scores: opt: 223%2C E(): 2.1e-07%2C(27.4%25 identity in 190 aa overlap)%3B and Q11033|YD63_MYCTU|MTCY02B10.27c|Rv1363c hypothetical 28.3 kDa protein (261 aa)%2C FASTA scores: opt: 238%2C E(): 2.7e-08%2C(27.6%25 identity in 163 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2390c;product=Conserved hypothetical protein;protein_id=CCP45178.1;transl_table=11
AL123456.3	EMBL	gene	2684679	2686370	.	+	.	ID=gene-Rv2391;Name=sirA;gbkey=Gene;gene=sirA;gene_biotype=protein_coding;locus_tag=Rv2391
AL123456.3	EMBL	CDS	2684679	2686370	.	+	0	ID=cds-CCP45179.1;Parent=gene-Rv2391;Dbxref=EnsemblGenomes-Gn:Rv2391,EnsemblGenomes-Tr:CCP45179,GOA:P9WJ03,InterPro:IPR005117,InterPro:IPR006066,InterPro:IPR006067,PDB:1ZJ8,PDB:1ZJ9,NCBI_GP:CCP45179.1;Name=CCP45179.1;Note=Rv2391%2C (MTCY253.30c)%2C len: 563 aa. SirA%2Cferredoxin-dependent sulfite reductase (See Schnell et al.%2C2005). Previously annotated as nirA. Similar to e.g. CAC33947|SCBAC1A6.26c Putative nitrite/sulphite reductase from Streptomyces coelicolor (565 aa)%2C FASTA scores: opt: 2335%2C E(): 1.2e-137%2C (60.1%25 identity in 567 aa overlap)%3B Q9RZD6|DRA0013 ferredoxin-nitrite reductase from Deinococcus radiodurans (563 aa)%2C FASTA scores: opt: 1141%2CE(): 2.2e-63%2C (39.6%25 identity in 533 aa overlap)%3B Q59656|NIRA (D31732|PEENIRNRT_1) ferredoxin-dependent nitrite reductase from Plectonema boryanum (654 aa) (see Suzuki %26 Kikuchi 1995)%2C FASTA scores: opt: 805%2C E(): 1.9e-42%2C (31.7%25 identity in 517 aa overlap)%3B Q55366|NIRA|SLR0898 ferredoxin-nitrite reductase from Synechocystis sp. strain PCC 6803 (502 aa)%2C FASTA scores: opt: 799%2C E(): 3.7e-42%2C (32.3%25 identity in 517 aa overlap)%3B etc. Highly similar (only in N-terminal part because shortened protein (fragment) owing to an IS900 insertion) to Q9K541|NIRA nitrate reductase (fragment) from Mycobacterium paratuberculosis (198 aa)%2C FASTA scores: opt: 798%2C E(): 2.1e-42%2C (65.4%25 identity in 182 aa overlap) (see Bull et al.%2C 2000).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sirA;locus_tag=Rv2391;product=Ferredoxin-dependent sulfite reductase SirA;protein_id=CCP45179.1;transl_table=11
AL123456.3	EMBL	gene	2686367	2687131	.	+	.	ID=gene-Rv2392;Name=cysH;gbkey=Gene;gene=cysH;gene_biotype=protein_coding;locus_tag=Rv2392
AL123456.3	EMBL	CDS	2686367	2687131	.	+	0	ID=cds-CCP45180.1;Parent=gene-Rv2392;Dbxref=EnsemblGenomes-Gn:Rv2392,EnsemblGenomes-Tr:CCP45180,GOA:P9WIK3,InterPro:IPR002500,InterPro:IPR004511,InterPro:IPR011798,InterPro:IPR014729,NCBI_GP:CCP45180.1;Name=CCP45180.1;Note=Rv2392%2C (MTCY253.29c)%2C len: 254 aa. Probable cysH%2C3'-phosphoadenosine 5'-phosphosulfate reductase (see citation below)%2C similar to many e.g. P94498|O34620|CYH1_BACSU|CYSH from Bacillus subtilis (233 aa)%2C FASTA scores: opt: 618%2C E(): 8.1e-32%2C (46.5%25 identity in 202 aa overlap)%3B Q9KCT3|CYSH|BH1486 from Bacillus halodurans (231 aa)%2C FASTA scores: opt: 560%2C E(): 3.6e-28%2C(41.3%25 identity in 230 aa overlap)%3B P56860|CYSH_DEIRA from Deinococcus radiodurans (255 aa)%2C FASTA scores: opt: 489%2CE(): 1.1e-23%2C (44.7%25 identity in 190 aa overlap)%3B etc. Belongs to the PAPS reductase family and CYSH subfamily. Note that operon cysA-cysW-cysT-subI%2C probably involved in sulfate transport%2C is near this putative ORF.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysH;locus_tag=Rv2392;product=Probable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase%2C thioredoxin DEP.) (padops reductase) (3'-phosphoadenylylsulfate reductase) (PAPS sulfotransferase);protein_id=CCP45180.1;transl_table=11
AL123456.3	EMBL	gene	2687128	2687973	.	+	.	ID=gene-Rv2393;Name=che1;gbkey=Gene;gene=che1;gene_biotype=protein_coding;locus_tag=Rv2393
AL123456.3	EMBL	CDS	2687128	2687973	.	+	0	ID=cds-CCP45181.1;Parent=gene-Rv2393;Dbxref=EnsemblGenomes-Gn:Rv2393,EnsemblGenomes-Tr:CCP45181,GOA:P71751,InterPro:IPR002762,UniProtKB/TrEMBL:P71751,NCBI_GP:CCP45181.1;Name=CCP45181.1;Note=Rv2393%2C (MTCY253.28c)%2C len: 281 aa. Che1%2Cferrochelatase (See Pinto et al.%2C 2007). Conserved protein%2Cwith some similarity to Q9L2E8|SC7A8.10c putative secreted protein from Streptomyces coelicolor (274 aa)%2C FASTA scores: opt: 407%2C E(): 2.8e-18%2C (37%25 identity in 246 aa overlap)%3B CAC38793|SCI39.05 Conserved hypothetical protein from Streptomyces coelicolor (305 aa)%2C FASTA scores: opt: 394%2C E(): 2e-17%2C (35.0%25 identity in 251 aa overlap)%3B AAK44492|MT0272 Chalcone/stilbene synthase family protein from Mycobacterium tuberculosis (247 aa)%2C FASTA scores: opt: 350%2C E(): 9.2e-15%2C (34.0%25 identity in 235 aa overlap)%3B P95216|Rv0259c|MTCY06A4.03c|Z86089 hypothetical protein from Mycobacterium tuberculosis (247 aa)%2C FASTA scores: opt: 345%2C E(): 1.9e-14%2C(33.6%25 identity in 235 aa overlap).;gbkey=CDS;gene=che1;locus_tag=Rv2393;product=Ferrochelatase Che1;protein_id=CCP45181.1;transl_table=11
AL123456.3	EMBL	repeat_region	2687128	2687179	.	+	.	ID=id-Rv2393;Note=52 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region;gene=che1;locus_tag=Rv2393
AL123456.3	EMBL	repeat_region	2687180	2687257	.	+	.	ID=id-Rv2393-2;Note=78 bp Mycobacterial Interspersed Repetitive Unit%2CClass I;gbkey=repeat_region;gene=che1;locus_tag=Rv2393
AL123456.3	EMBL	gene	2688010	2689941	.	+	.	ID=gene-Rv2394;Name=ggtB;gbkey=Gene;gene=ggtB;gene_biotype=protein_coding;locus_tag=Rv2394
AL123456.3	EMBL	CDS	2688010	2689941	.	+	0	ID=cds-CCP45182.1;Parent=gene-Rv2394;Dbxref=EnsemblGenomes-Gn:Rv2394,EnsemblGenomes-Tr:CCP45182,GOA:P71750,InterPro:IPR000101,InterPro:IPR029055,UniProtKB/TrEMBL:P71750,NCBI_GP:CCP45182.1;Name=CCP45182.1;Note=Rv2394%2C (MTCY253.27c)%2C len: 643 aa. Probable ggtB%2Cgamma-glutamyltranspeptidase precursor%2C similar to many e.g. Q9KVF2|VC0194 from Vibrio cholerae (588 aa)%2C FASTA scores: opt: 943%2C E(): 7.5e-47%2C (40.0%25 identity in 597 aa overlap)%3B O69935|SC3C8.26 from Streptomyces coelicolor (603 aa)%2C FASTA scores: opt: 822%2C E(): 7.2e-40%2C (33.6%25 identity in 622 aa overlap)%3B P54422|GGT_BACSU from Bacillus subtilis (587 aa) FASTA scores: opt: 491%2C E(): 8.2e-21%2C (33.4%25 identity in 574 aa overlap)%3B etc. Has potential signal peptide and appropriately positioned prokaryotic lipoprotein attachment site (PS00013).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ggtB;locus_tag=Rv2394;product=Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase);protein_id=CCP45182.1;transl_table=11
AL123456.3	EMBL	gene	2690072	2692075	.	+	.	ID=gene-Rv2395;Name=Rv2395;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2395
AL123456.3	EMBL	CDS	2690072	2692075	.	+	0	ID=cds-CCP45183.1;Parent=gene-Rv2395;Dbxref=EnsemblGenomes-Gn:Rv2395,EnsemblGenomes-Tr:CCP45183,GOA:P71749,InterPro:IPR004813,InterPro:IPR004814,UniProtKB/TrEMBL:P71749,NCBI_GP:CCP45183.1;Name=CCP45183.1;Note=Rv2395%2C (MTCY253.26c)%2C len: 667 aa. Probable conserved integral membrane protein%2C similar to AAK24613|CC2646 oligopeptide transporter/opt family protein from Caulobacter crescentus (666 aa)%2C FASTA scores: opt: 1638%2C E(): 4.8e-86%2C (51.0%25 identity in 658 aa overlap)%3B Q9PIS5|CJ0204 putative integral membrane protein from Campylobacter jejuni (665 aa)%2C FASTA scores: opt: 1484%2CE(): 2.9e-77%2C (40.6%25 identity in 658 aa overlap)%3B and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa)%2C FASTA scores: opt: 1449%2C E(): 2.8e-75%2C (42.15%25 identity in 624 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2395;product=Probable conserved integral membrane protein;protein_id=CCP45183.1;transl_table=11
AL123456.3	EMBL	gene	2692172	2692521	.	+	.	ID=gene-mcr7;Name=mcr7;gbkey=Gene;gene=mcr7;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	2692172	2692521	.	+	.	ID=rna-mcr7;Parent=gene-mcr7;Note=mcr7%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped.;gbkey=ncRNA;gene=mcr7;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	2692172	2692521	.	+	.	ID=exon-mcr7-1;Parent=rna-mcr7;Note=mcr7%2C putative small regulatory RNA (See DiChiara et al.%2C 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur%2C 3'-end not mapped.;gbkey=ncRNA;gene=mcr7;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	2692224	2692439	.	+	.	ID=gene-Rv2395A;Name=aprA;gbkey=Gene;gene=aprA;gene_biotype=protein_coding;locus_tag=Rv2395A
AL123456.3	EMBL	CDS	2692224	2692439	.	+	0	ID=cds-CCP45184.1;Parent=gene-Rv2395A;Dbxref=EnsemblGenomes-Gn:Rv2395A,EnsemblGenomes-Tr:CCP45184,UniProtKB/TrEMBL:V5QPR9,NCBI_GP:CCP45184.1;Name=CCP45184.1;Note=Rv2395A%2C len: 71 aa. AprA%2C acid and phagosome regulated protein A%2C restricted to M. tuberculosis complex. Note completely overlapped by sRNA mcr7.;gbkey=CDS;gene=aprA;locus_tag=Rv2395A;product=Acid and phagosome regulated protein A AprA;protein_id=CCP45184.1;transl_table=11
AL123456.3	EMBL	gene	2692551	2692715	.	+	.	ID=gene-Rv2395B;Name=aprB;gbkey=Gene;gene=aprB;gene_biotype=protein_coding;locus_tag=Rv2395B
AL123456.3	EMBL	CDS	2692551	2692715	.	+	0	ID=cds-CCP45185.1;Parent=gene-Rv2395B;Dbxref=EnsemblGenomes-Gn:Rv2395B,EnsemblGenomes-Tr:CCP45185,UniProtKB/TrEMBL:V5QRX2,NCBI_GP:CCP45185.1;Name=CCP45185.1;Note=Rv2395B%2C len: 54 aa. AprB%2C acid and phagosome regulated protein B%2C restricted to M. tuberculosis complex.;gbkey=CDS;gene=aprB;locus_tag=Rv2395B;product=Acid and phagosome regulated protein B AprB;protein_id=CCP45185.1;transl_table=11
AL123456.3	EMBL	gene	2692799	2693884	.	+	.	ID=gene-Rv2396;Name=PE_PGRS41;gbkey=Gene;gene=PE_PGRS41;gene_biotype=protein_coding;gene_synonym=aprC;locus_tag=Rv2396
AL123456.3	EMBL	CDS	2692799	2693884	.	+	0	ID=cds-CCP45186.1;Parent=gene-Rv2396;Dbxref=EnsemblGenomes-Gn:Rv2396,EnsemblGenomes-Tr:CCP45186,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FE6,NCBI_GP:CCP45186.1;Name=CCP45186.1;Note=Rv2396%2C (MTCY253.25c)%2C len: 361 aa. PE_PGRS41%2Cmember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below). Also known as aprC%2C acid and phagosome regulated protein C%2Crestricted to M. tuberculosis complex (See Abramovitch et al.%2C 2011). Contains PS00583 pfkB family of carbohydrate kinases signature 1. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=PE_PGRS41;inference=protein motif:PROSITE:PS00583;locus_tag=Rv2396;product=PE-PGRS family protein PE_PGRS41;protein_id=CCP45186.1;transl_table=11
AL123456.3	EMBL	gene	2693909	2694964	.	-	.	ID=gene-Rv2397c;Name=cysA1;gbkey=Gene;gene=cysA1;gene_biotype=protein_coding;gene_synonym=cysA;locus_tag=Rv2397c
AL123456.3	EMBL	CDS	2693909	2694964	.	-	0	ID=cds-CCP45187.1;Parent=gene-Rv2397c;Dbxref=EnsemblGenomes-Gn:Rv2397c,EnsemblGenomes-Tr:CCP45187,GOA:P9WQM1,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR005116,InterPro:IPR005666,InterPro:IPR008995,InterPro:IPR014769,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP45187.1;Name=CCP45187.1;Note=Rv2397c%2C (MTCY253.24)%2C len: 351 aa. cysA1%2Csulfate-transport ATP-binding protein ABC transporter (see citations below)%2C similar to other sulfate ABC transporter ATP-binding proteins e.g. P14788|CYSA_SYNP7 from Synechococcus sp. (344 aa)%2C FASTA scores: opt: 1112%2C E(): 2.6e-56%2C (54.6%25 identity in 328 aa overlap)%3B P74548|CYSA_SYNY3 from Synechocystis sp. (355 aa)%2C FASTA scores: opt: 1063%2C E(): 1.7e-53%2C (51.9%25 identity in 343 aa overlap)%3B Q9I6L0|CYSA|PA0280 from Pseudomonas aeruginosa (329 aa)%2C FASTA scores: opt: 987%2C E(): 3.3e-49%2C (49.2%25 identity in 339 aa overlap)%3B etc. Also similar to many ATP-binding proteins from Mycobacterium tuberculosis e.g. Rv2038c%2C Rv1238%2C Rv2832c%2C etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters). Note that previously known as cysA.;gbkey=CDS;gene=cysA1;inference=protein motif:PROSITE:PS00211;locus_tag=Rv2397c;product=Sulfate-transport ATP-binding protein ABC transporter CysA1;protein_id=CCP45187.1;transl_table=11
AL123456.3	EMBL	gene	2694981	2695799	.	-	.	ID=gene-Rv2398c;Name=cysW;gbkey=Gene;gene=cysW;gene_biotype=protein_coding;locus_tag=Rv2398c
AL123456.3	EMBL	CDS	2694981	2695799	.	-	0	ID=cds-CCP45188.1;Parent=gene-Rv2398c;Dbxref=EnsemblGenomes-Gn:Rv2398c,EnsemblGenomes-Tr:CCP45188,GOA:P71746,InterPro:IPR000515,InterPro:IPR005667,InterPro:IPR011866,UniProtKB/TrEMBL:P71746,NCBI_GP:CCP45188.1;Name=CCP45188.1;Note=Rv2398c%2C (MTCY253.23)%2C len: 272 aa. Probable cysW%2Csulfate-transport integral membrane protein ABC transporter (see citations below)%2C similar to others e.g. Q9K877|CYSW|BH3129 sulfate ABC transporter (permease) from Bacillus halodurans (287 aa)%2C FASTA scores: opt: 765%2C E(): 4.1e-40%2C (43.8%25 identity in 249 aa overlap)%3B P27370|CYSW_SYNP7 sulfate transport system (permease) protein from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (286 aa)%2C FASTA scores: opt: 757%2C E(): 1.3e-39%2C (44.3%25 identity in 264 aa overlap)%3B Q9I6K9|CYSW|PA0281 sulfate transport protein from Pseudomonas aeruginosa (289 aa)%2C FASTA scores: opt: 753%2CE(): 2.3e-39%2C (44.4%25 identity in 250 aa overlap)%3B P16702|P76534|CYSW_ECOLI sulfate transport system permease from Escherichia coli (291 aa)%2C FASTA scores: opt: 633%2CE(): 5.7e-32%2C (38.2%25 identity in 267 aa overlap)%3B etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature. Similarity with integral membrane components of other binding-protein-dependent transport systems and belongs to the CYSTW subfamily.;gbkey=CDS;gene=cysW;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2398c;product=Probable sulfate-transport integral membrane protein ABC transporter CysW;protein_id=CCP45188.1;transl_table=11
AL123456.3	EMBL	gene	2695796	2696647	.	-	.	ID=gene-Rv2399c;Name=cysT;gbkey=Gene;gene=cysT;gene_biotype=protein_coding;locus_tag=Rv2399c
AL123456.3	EMBL	CDS	2695796	2696647	.	-	0	ID=cds-CCP45189.1;Parent=gene-Rv2399c;Dbxref=EnsemblGenomes-Gn:Rv2399c,EnsemblGenomes-Tr:CCP45189,GOA:P71745,InterPro:IPR000515,InterPro:IPR005667,InterPro:IPR011865,UniProtKB/TrEMBL:P71745,NCBI_GP:CCP45189.1;Name=CCP45189.1;Note=Rv2399c%2C (MTCY253.22)%2C len: 283 aa. Probable cysT%2Csulfate-transport integral membrane protein ABC transporter (see citations below)%2C similar to others e.g. BAB48989|MLR1667 permease protein of sulfate ABC transporter from Rhizobium loti (283 aa)%2C FASTA scores: opt: 756%2C E(): 7.9e-40%2C (40.95%25 identity in 271 aa overlap)%3B Q9K878|cyst|BH3128 sulfate ABC transporter (permease) from Bacillus halodurans (279 aa)%2C FASTA scores: opt: 750%2C E(): 1.8e-39%2C (44.55%25 identity in 258 aa overlap)%3B P16701|CYST_ECOLI|CYSU|cyst|B2424 from Escherichia coli (277 aa)%2C FASTA scores: opt: 669%2C E(): 1.9e-34%2C (40.0%25 identity in 260 aa overlap)%3B etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature%2C and PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the CYSTW subfamily.;gbkey=CDS;gene=cysT;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2399c;product=Probable sulfate-transport integral membrane protein ABC transporter CysT;protein_id=CCP45189.1;transl_table=11
AL123456.3	EMBL	gene	2696644	2697714	.	-	.	ID=gene-Rv2400c;Name=subI;gbkey=Gene;gene=subI;gene_biotype=protein_coding;locus_tag=Rv2400c
AL123456.3	EMBL	CDS	2696644	2697714	.	-	0	ID=cds-CCP45190.1;Parent=gene-Rv2400c;Dbxref=EnsemblGenomes-Gn:Rv2400c,EnsemblGenomes-Tr:CCP45190,GOA:P71744,InterPro:IPR005669,UniProtKB/TrEMBL:P71744,NCBI_GP:CCP45190.1;Name=CCP45190.1;Note=Rv2400c%2C (MTCY253.21)%2C len: 356 aa. Probable subI%2Csulfate-binding lipoprotein component of sulfate transport system (see citations below)%2C equivalent to Q9CCN3|SUBI|ML0615 (alias Q49748|B1937_F1_11%2C 358 aa) putative sulphate-binding protein from Mycobacterium leprae (348 aa)%2C FASTA scores: opt: 1775%2C E(): 2.3e-102%2C (76.45%25 identity in 340 aa overlap). Also similar to others and other substrate-binding proteins e.g. P27366|SUBI_SYNP7|SBPA sulfate-binding protein precursor from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (350 aa)%2C FASTA scores: opt: 703%2C E(): 4.6e-36%2C (35.6%25 identity in 351 aa overlap)%3B Q9I6K7|SBP|PA0283 sulfate-binding protein precursor from Pseudomonas aeruginosa (332 aa)%2C FASTA scores: opt: 591%2C E(): 3.7e-29%2C(36.9%25 identity in 317 aa overlap)%3B CAC49112|SMB21133 putative sulfate uptake ABC transporter periplasmic solute-binding protein precursor from Rhizobium meliloti (Sinorhizobium meliloti) (341 aa)%2C FASTA scores: opt: 569%2CE(): 8.8e-28%2C (36.15%25 identity in 321 aa overlap)%3B etc. Belongs to the prokaryotic sulfate binding protein family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=subI;locus_tag=Rv2400c;product=Probable sulfate-binding lipoprotein SubI;protein_id=CCP45190.1;transl_table=11
AL123456.3	EMBL	gene	2697728	2698057	.	+	.	ID=gene-Rv2401;Name=Rv2401;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2401
AL123456.3	EMBL	CDS	2697728	2698057	.	+	0	ID=cds-CCP45191.1;Parent=gene-Rv2401;Dbxref=EnsemblGenomes-Gn:Rv2401,EnsemblGenomes-Tr:CCP45191,GOA:O86326,UniProtKB/TrEMBL:O86326,NCBI_GP:CCP45191.1;Name=CCP45191.1;Note=Rv2401%2C (MTCY253.19c)%2C len: 109 aa. Hypothetical unknown protein. Equivalent to AAK46768 from Mycobacterium tuberculosis strain CDC1551 (134 aa) but shorter 25 aa. N-terminus extended since first submission (previously 72 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2401;product=Hypothetical protein;protein_id=CCP45191.1;transl_table=11
AL123456.3	EMBL	gene	2698042	2698245	.	-	.	ID=gene-Rv2401A;Name=Rv2401A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2401A
AL123456.3	EMBL	CDS	2698042	2698245	.	-	0	ID=cds-CCP45192.1;Parent=gene-Rv2401A;Dbxref=EnsemblGenomes-Gn:Rv2401A,EnsemblGenomes-Tr:CCP45192,UniProtKB/TrEMBL:Q79FE4,NCBI_GP:CCP45192.1;Name=CCP45192.1;Note=Rv2401A%2C len: 67 aa. Possible conserved membrane protein%2C highly similar%2C but with 29 aa shorter%2C to ML0614|AL583919_34|Q49760 from Mycobacterium leprae (95 aa)%2C FASTA scores: opt: 297%2C E(): 3.6e-15%2C (67.7%25 identity in 65 aa overlap). Has hydrophobic stretch.;gbkey=CDS;locus_tag=Rv2401A;product=Possible conserved membrane protein;protein_id=CCP45192.1;transl_table=11
AL123456.3	EMBL	gene	2698529	2700457	.	+	.	ID=gene-Rv2402;Name=Rv2402;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2402
AL123456.3	EMBL	CDS	2698529	2700457	.	+	0	ID=cds-CCP45193.1;Parent=gene-Rv2402;Dbxref=EnsemblGenomes-Gn:Rv2402,EnsemblGenomes-Tr:CCP45193,GOA:P71741,InterPro:IPR008928,InterPro:IPR011613,InterPro:IPR012341,NCBI_GP:CCP45193.1;Name=CCP45193.1;Note=Rv2402%2C (MTCY253.18c)%2C len: 642 aa. Conserved protein%2C highly similar to others e.g. 9X8C4|SCE36.11c conserved hypothetical protein (fragment) from Streptomyces coelicolor (612 aa)%2C FASTA scores: opt: 1283%2C E(): 6.5e-75%2C(41.9%25 identity in 623 aa overlap)%3B Q9RJ38|SCI8.15 hypothetical 66.3 KDA protein from Streptomyces coelicolor (595 aa)%2C FASTA scores: opt: 1152%2C E(): 1.7e-66%2C (39.9%25 identity in 622 aa overlap)%2C Q9S223|CI51.17 hypothetical 68.4 KDA protein from Streptomyces coelicolor (612 aa)%2CFASTA scores: opt: 1146%2C E(): 4.2e-66%2C (40.6%25 identity in 623 aa overlap)%3B YAY3_SCHPO|Q10211|c4h3.03c hypothetical 74.5 kDa protein from Schizosaccharomyces pombe (Fission yeast) (649 aa) FASTA scores: opt: 999%2C E(): 1.3e-56%2C(35.0%25 identity in 642 aa overlap)%3B etc. Contains possible helix-turn-helix motif%2C at aa 224-245 (+4.68 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2402;product=Conserved protein;protein_id=CCP45193.1;transl_table=11
AL123456.3	EMBL	gene	2700535	2701290	.	-	.	ID=gene-Rv2403c;Name=lppR;gbkey=Gene;gene=lppR;gene_biotype=protein_coding;locus_tag=Rv2403c
AL123456.3	EMBL	CDS	2700535	2701290	.	-	0	ID=cds-CCP45194.1;Parent=gene-Rv2403c;Dbxref=EnsemblGenomes-Gn:Rv2403c,EnsemblGenomes-Tr:CCP45194,InterPro:IPR026954,UniProtKB/TrEMBL:P71740,NCBI_GP:CCP45194.1;Name=CCP45194.1;Note=Rv2403c%2C (MTCY253.17)%2C len: 251 aa. Probable lppR%2Cconserved lipoprotein%2C with weak similarity with mycobacterial serine/threonine protein kinases e.g. AAK45563|MT1304 from Mycobacterium tuberculosis strain CDC1551 (626 aa)%2C FASTA scores: opt: 186%2C E(): 0.00023%2C(24.4%25 identity in 238 aa overlap)%2C and the C-terminal part of Q11053|Rv1266c|MTCY50.16|PKNH_MYCTU from Mycobacterium tuberculosis (626 aa)%2C FASTA scores: opt: 185%2C E()%3D 0.00027%2C (24.35%25 identity in 238 aa overlap). Has signal peptide and appropriate positioned prokaryotic lipoprotein attachment site (PS00013). Could belong to the Ser/Thr family of protein kinases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppR;locus_tag=Rv2403c;product=Probable conserved lipoprotein LppR;protein_id=CCP45194.1;transl_table=11
AL123456.3	EMBL	gene	2701287	2703248	.	-	.	ID=gene-Rv2404c;Name=lepA;gbkey=Gene;gene=lepA;gene_biotype=protein_coding;locus_tag=Rv2404c
AL123456.3	EMBL	CDS	2701287	2703248	.	-	0	ID=cds-CCP45195.1;Parent=gene-Rv2404c;Dbxref=EnsemblGenomes-Gn:Rv2404c,EnsemblGenomes-Tr:CCP45195,GOA:P9WK97,InterPro:IPR000640,InterPro:IPR000795,InterPro:IPR004161,InterPro:IPR005225,InterPro:IPR006297,InterPro:IPR009000,InterPro:IPR009022,InterPro:IPR013842,InterPro:IPR027417,NCBI_GP:CCP45195.1;Name=CCP45195.1;Note=Rv2404c%2C (MT2476%2C MTCY253.16)%2C len: 653 aa. Probable lepA%2C GTP-binding protein (a protein of unknown function%2Cbut apparently with membrane-related functions and very similar to protein synthesis elongation factors%3B see citations below). Equivalent to P53530|LEPA_MYCLE|ML0611|B1937_F3_81 GTP-binding protein from Mycobacterium leprae (646 aa)%2C FASTA scores: opt: 3610%2C E(): 1.2e-205%2C (88.0%25 identity in 649 aa overlap). Also highly similar to many GTP-binding proteins LEPA e.g. Q9RDC9|LEPA_STRCO|SCC77.29c from Streptomyces coelicolor (622 aa)%2C FASTA scores: opt: 3046%2C E(): 2.3e-172%2C (74.3%25 identity in 626 aa overlap)%3B P37949|LEPA_BACSU from B. subtilis (612 aa)%2C FASTA scores: opt: 2430%2C E(): 5.3e-136%2C(58.7%25 identity in 610 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00301 GTP-binding elongation factors signature. Belongs to the GTP-binding elongation factor family%2C LEPA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lepA;inference=protein motif:PROSITE:PS00301;locus_tag=Rv2404c;product=Probable GTP-binding protein LepA (GTP-binding elongation factor);protein_id=CCP45195.1;transl_table=11
AL123456.3	EMBL	gene	2703269	2703838	.	+	.	ID=gene-Rv2405;Name=Rv2405;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2405
AL123456.3	EMBL	CDS	2703269	2703838	.	+	0	ID=cds-CCP45196.1;Parent=gene-Rv2405;Dbxref=EnsemblGenomes-Gn:Rv2405,EnsemblGenomes-Tr:CCP45196,GOA:P71738,InterPro:IPR003477,InterPro:IPR011067,UniProtKB/TrEMBL:P71738,NCBI_GP:CCP45196.1;Name=CCP45196.1;Note=Rv2405%2C (MTCY253.15c)%2C len: 189 aa. Conserved protein%2C identical (but N-terminus longer 40 residues) to AAK46773|MT2477 hypothetical protein from Mycobacterium tuberculosis strain CDC1551. Also highly similar%2C but N-terminus longer 38 residues%2C to Q9RD03|SCCM1.41 hypothetical 17.4 KDA protein from Streptomyces coelicolor (154 aa)%2C FASTA scores: opt: 451%2C E(): 2e-22%2C (48.7%25 identity in 154 aa overlap). Shows also similarity with hypothetical proteins from other species.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2405;product=Conserved protein;protein_id=CCP45196.1;transl_table=11
AL123456.3	EMBL	gene	2704009	2704437	.	-	.	ID=gene-Rv2406c;Name=Rv2406c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2406c
AL123456.3	EMBL	CDS	2704009	2704437	.	-	0	ID=cds-CCP45197.1;Parent=gene-Rv2406c;Dbxref=EnsemblGenomes-Gn:Rv2406c,EnsemblGenomes-Tr:CCP45197,GOA:P71737,InterPro:IPR000644,UniProtKB/TrEMBL:P71737,NCBI_GP:CCP45197.1;Name=CCP45197.1;Note=Rv2406c%2C (MTCY253.14)%2C len: 142 aa. Conserved protein. C-terminal region is identical with many CBS domain protein e.g. AAK46774|MT2478 CBS domain protein from Mycobacterium tuberculosis strain CDC1551 (aa 47-142)%2CFASTA scores: opt: 594%2C E(): 1.9e-30%2C (98.97%25 identity in 97 aa overlap)%3B etc. Also similar to other hypothetical proteins e.g. AAK24594|CC2626 CBS domain protein from Caulobacter crescentus (157 aa)%2C FASTA scores: opt: 377%2CE(): 8.3e-17%2C (42.55%25 identity in 141 aa overlap)%3B BAB47826|MLR0188 from Rhizobium loti%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2406c;product=Conserved protein;protein_id=CCP45197.1;transl_table=11
AL123456.3	EMBL	gene	2704697	2705518	.	+	.	ID=gene-Rv2407;Name=Rv2407;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2407
AL123456.3	EMBL	CDS	2704697	2705518	.	+	0	ID=cds-CCP45198.1;Parent=gene-Rv2407;Dbxref=EnsemblGenomes-Gn:Rv2407,EnsemblGenomes-Tr:CCP45198,GOA:P9WGZ5,InterPro:IPR001279,InterPro:IPR013471,NCBI_GP:CCP45198.1;Name=CCP45198.1;Note=Rv2407%2C (MTCY253.13c)%2C len: 273 aa. Conserved hypothetical protein%2C highly similar (but longer at N-terminus) to AAK46775|MT2479 putative arylsulfatase from Mycobacterium tuberculosis strain CDC1551 (224 aa) FASTA scores: opt: 1433%2C E(): 2.5e-81%2C (96.43%25 identity in 224 aa overlap)%3B O33130|MLCL536.01 hypothetical protein from Mycobacterium leprae (220 aa)%2C FASTA scores: opt: 658%2C E(): 1.5e-33%2C (56.75%25 identity in 215 aa overlap). Also similar to AAK23160|CC1176 Metallo-beta-lactamase family protein from Caulobacter crescentus (317 aa)%2C FASTA scores: opt: 286%2C E(): 1.8e-10%2C (33%25 identity in 291 aa overlap). And similar to other hypothetical proteins eg Q49744|B1937_C1_163 hypothetical 22.6 KDA protein (precursor) from Mycobacterium leprae (211 aa)%2C FASTA scores: opt: 623%2C E(): 2.1e-31%2C (56.3%25 identity in 206 aa overlap)%3B O27859|MTH1831 conserved protein from Methanothermobacter thermautotrophicus (307 aa)%2C FASTA scores: opt: 268%2C E(): 2.3e-09%2C (28.35%25 identity in 307 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2407;product=Conserved hypothetical protein;protein_id=CCP45198.1;transl_table=11
AL123456.3	EMBL	gene	2706017	2706736	.	+	.	ID=gene-Rv2408;Name=PE24;gbkey=Gene;gene=PE24;gene_biotype=protein_coding;locus_tag=Rv2408
AL123456.3	EMBL	CDS	2706017	2706736	.	+	0	ID=cds-CCP45199.1;Parent=gene-Rv2408;Dbxref=EnsemblGenomes-Gn:Rv2408,EnsemblGenomes-Tr:CCP45199,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FE3,NCBI_GP:CCP45199.1;Name=CCP45199.1;Note=Rv2408%2C (MTCY253.12c)%2C len: 239 aa. Possibly PE24%2C a member of PE family (see citation below)%2C similar to AAK46440|MT2159 from Mycobacterium tuberculosis strain CDC1551 (491 aa) FASTA scores: opt: 269%2C E(): 5.4e-08%2C(38.45%25 identity in 156 aa overlap) and AAK45466|MT1209 from Mycobacterium tuberculosis strain CDC1551 (308 aa)%2CFASTA scores: opt: 265%2C E(): 6.3e-08%2C (36.0%25 identity in 197 aa overlap).;gbkey=CDS;gene=PE24;locus_tag=Rv2408;product=Possible PE family-related protein PE24;protein_id=CCP45199.1;transl_table=11
AL123456.3	EMBL	gene	2706494	2707333	.	-	.	ID=gene-Rv2409c;Name=Rv2409c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2409c
AL123456.3	EMBL	CDS	2706494	2707333	.	-	0	ID=cds-CCP45200.1;Parent=gene-Rv2409c;Dbxref=EnsemblGenomes-Gn:Rv2409c,EnsemblGenomes-Tr:CCP45200,GOA:P71734,InterPro:IPR002931,InterPro:IPR013589,UniProtKB/TrEMBL:P71734,NCBI_GP:CCP45200.1;Name=CCP45200.1;Note=Rv2409c%2C (MTCY253.11)%2C len: 279 aa. Conserved protein%2C equivalent to Q49757|YP69_MYCLE|G466976|B1937_F2_39 hypothetical protein from Mycobacterium leprae (279 aa)%2C FASTA scores: opt: 1564%2C E(): 4.6e-95%2C (82.1%25 identity in 279 aa overlap). Also similar to others e.g. Q9RSX6|DR1993 from Deinococcus radiodurans (274 aa)%2C FASTA scores: opt: 494%2C E(): 4e-25%2C(35.1%25 identity in 282 aa overlap)%3B BAB49898|Mll2875 from Rhizobium loti (Mesorhizobium loti) (294 aa)%2C FASTA scores: opt: 382%2C E(): 8.9e-18%2C (29.75%25 identity in 269 aa overlap)%3B Q9I305|PA1732 from Pseudomonas aeruginosa (266 aa)%2C FASTA scores: opt: 326%2C E(): 3.7e-14%2C (31.25%25 identity in 275 aa overlap)%3B etc. Also similar to Rv2569c|MTCY227.32 from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2409c;product=Conserved protein;protein_id=CCP45200.1;transl_table=11
AL123456.3	EMBL	gene	2707333	2708310	.	-	.	ID=gene-Rv2410c;Name=Rv2410c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2410c
AL123456.3	EMBL	CDS	2707333	2708310	.	-	0	ID=cds-CCP45201.1;Parent=gene-Rv2410c;Dbxref=EnsemblGenomes-Gn:Rv2410c,EnsemblGenomes-Tr:CCP45201,InterPro:IPR007296,UniProtKB/TrEMBL:P71733,NCBI_GP:CCP45201.1;Name=CCP45201.1;Note=Rv2410c%2C (MTCY253.10)%2C len: 325 aa. Conserved protein%2C equivalent to Q49770|CAC30114|ML0606 conserved hypothetical protein from Mycobacterium leprae (325 aa)%2CFASTA scores: opt: 1928%2C E(): 3.5e-117%2C (90.75%25 identity in 325 aa overlap). Also some similarity with other hypothetical proteins e.g. Q9RST2|DR2041 conserved hypothetical protein from Deinococcus radiodurans (316 aa)%2CFASTA scores: opt: 329%2C E(): 5.3e-14%2C (32.4%25 identity in 318 aa overlap)%3B C-terminus of Q9HUN7|PA4927 hypothetical protein from Pseudomonas aeruginosa (830 aa)%2C FASTA scores: opt: 297%2C E(): 1.5e-11%2C (27.6%25 identity in 315 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2410c;product=Conserved protein;protein_id=CCP45201.1;transl_table=11
AL123456.3	EMBL	gene	2708310	2709965	.	-	.	ID=gene-Rv2411c;Name=Rv2411c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2411c
AL123456.3	EMBL	CDS	2708310	2709965	.	-	0	ID=cds-CCP45202.1;Parent=gene-Rv2411c;Dbxref=EnsemblGenomes-Gn:Rv2411c,EnsemblGenomes-Tr:CCP45202,InterPro:IPR007302,InterPro:IPR016450,NCBI_GP:CCP45202.1;Name=CCP45202.1;Note=Rv2411c%2C (MTCY253.09c)%2C len: 551 aa. Hypothetical protein%2C highly similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 hypothetical 61.8 KDA protein from Mycobacterium leprae (561 aa)%2C FASTA scores%2C opt: 3163%2C E(): 4.1e-178%2C (87.35%25 identity in 554 aa overlap). Also highly similar%2C except in N-terminus%2C to others e.g. Q55587|Y335_SYNY3|SLL0335 hypothetical protein from Synechocystis sp. strain PCC 6803 (481 aa)%2C FASTA scores: opt: 1620%2C E(): 1.2e-87%2C (52.8%25 identity in 468 aa overlap)%3B Q9I307|PA1730 hypothetical protein from Pseudomonas aeruginosa (470 aa)%2C FASTA scores: opt: 1574%2C E(): 5.8e-85%2C (52.7%25 identity in 467 aa overlap)%3B Q9RST1|DR2042 conserved hypothetical protein from Deinococcus radiodurans (655 aa)%2C FASTA scores: opt: 1561%2CE(): 4.4e-84%2C (53.3%25 identity in 467 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2411c;product=Conserved hypothetical protein;protein_id=CCP45202.1;transl_table=11
AL123456.3	EMBL	gene	2710075	2710335	.	+	.	ID=gene-Rv2412;Name=rpsT;gbkey=Gene;gene=rpsT;gene_biotype=protein_coding;locus_tag=Rv2412
AL123456.3	EMBL	CDS	2710075	2710335	.	+	0	ID=cds-CCP45203.1;Parent=gene-Rv2412;Dbxref=EnsemblGenomes-Gn:Rv2412,EnsemblGenomes-Tr:CCP45203,GOA:P9WH41,InterPro:IPR002583,NCBI_GP:CCP45203.1;Name=CCP45203.1;Note=Rv2412%2C (MT2485%2C MTCY253.08c)%2C len: 86 aa. rpsT%2C 30s ribosomal protein s20%2C equivalent to O33132|RS20_MYCLE|L0604|MLCL536.06 30S ribosomal protein S20 from Mycobacterium leprae (86 aa)%2C FASTA scores: opt: 456%2C E(): 4.6e-24%2C (87.20%25 identity in 86 aa overlap). Also highly similar or similar to others e.g. Q9RDM3|RPST|SCC123.01 30S ribosomal protein S20 from Streptomyces coelicolor (88 aa)%2C FASTA scores: opt: 363%2CE(): 7.1e-18%2C (70.95%25 identity in 86 aa overlap)%3B Q9KD79|RPST|BH1339 ribosomal protein S20 (BS20) from Bacillus halodurans (91 aa)%2C FASTA scores: opt: 252%2C E(): 1.8e-10%2C (49.4%25 identity in 85 aa overlap)%3B P02378|RS20_ECOLI 30s ribosomal protein s20 from Escherichia coli (86 aa)%2C FASTA scores: opt: 210%2C E(): 1e-07%2C (42.4%25 identity in 85 aa overlap)%3B etc. Belongs to the S20P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsT;locus_tag=Rv2412;product=30S ribosomal protein S20 RpsT;protein_id=CCP45203.1;transl_table=11
AL123456.3	EMBL	gene	2710351	2711301	.	-	.	ID=gene-Rv2413c;Name=Rv2413c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2413c
AL123456.3	EMBL	CDS	2710351	2711301	.	-	0	ID=cds-CCP45204.1;Parent=gene-Rv2413c;Dbxref=EnsemblGenomes-Gn:Rv2413c,EnsemblGenomes-Tr:CCP45204,GOA:P71730,InterPro:IPR008921,InterPro:IPR010372,InterPro:IPR027417,UniProtKB/TrEMBL:P71730,NCBI_GP:CCP45204.1;Name=CCP45204.1;Note=Rv2413c%2C (MTCY253.07)%2C len: 316 aa. Conserved hypothetical protein%2C highly similar to O33133|MLCL536.07c|ML0603|Q49756|G466975|B1937_F2_36 hypothetical 39.1 KDA protein from Mycobacterium leprae (389 aa)%2C FASTA scores: opt: 1683%2C E(): 1.8e-88%2C (83.9%25 identity in 316 aa overlap). ML0603 is a putative lipoprotein with an N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site that is not present in Rv2413c as this seems to be 73 aa shorter. Also some similarity with various proteins from other organisms e.g. Q9RDM2|SCC123.02c putative DNA-binding protein from Streptomyces coelicolor (336 aa)%2C FASTA scores: opt: 792%2CE(): 6.1e-38%2C (42.4%25 identity in 316 aa overlap)%3B Q9HX31|HOLA|PA3989 DNA polymerase III%2C delta subunit from Pseudomonas aeruginosa (345 aa)%2C FASTA scores: opt: 173%2CE(): 0.0084%2C (25.4%25 identity in 307 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2413c;product=Conserved hypothetical protein;protein_id=CCP45204.1;transl_table=11
AL123456.3	EMBL	gene	2711332	2712876	.	-	.	ID=gene-Rv2414c;Name=Rv2414c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2414c
AL123456.3	EMBL	CDS	2711332	2712876	.	-	0	ID=cds-CCP45205.1;Parent=gene-Rv2414c;Dbxref=EnsemblGenomes-Gn:Rv2414c,EnsemblGenomes-Tr:CCP45205,InterPro:IPR004477,UniProtKB/TrEMBL:P71729,NCBI_GP:CCP45205.1;Name=CCP45205.1;Note=Rv2414c%2C (MTCY253.06)%2C len: 514 aa. Conserved hypothetical protein%2C showing some similarity with come operon proteins 3 (COMEC or COME3) e.g. Q9RTB1|DR1854 putative competence protein COMEC/REC2 from Deinococcus radiodurans (755 aa)%2C FASTA scores: opt: 311%2C E(): 8.2e-11%2C(27.3%25 identity in 538 aa overlap)%3B P73100|come|SLL1929 come protein from Synechocystis sp. strain PCC 6803 (709 aa)%2C FASTA scores: opt: 302%2C E(): 2.6e-10%2C (26.3%25 identity in 323 aa overlap) (no similarity on N-terminus)%3B P39695|CME3_BACSU come operon protein 3 from Bacillus subtilis (776 aa)%2C FASTA scores: opt: 273%2C E(): 1.4e-08%2C(25.2%25 identity in 282 aa overlap) (no similarity on N-terminus)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2414c;product=Conserved hypothetical protein;protein_id=CCP45205.1;transl_table=11
AL123456.3	EMBL	gene	2712891	2713784	.	-	.	ID=gene-Rv2415c;Name=Rv2415c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2415c
AL123456.3	EMBL	CDS	2712891	2713784	.	-	0	ID=cds-CCP45206.1;Parent=gene-Rv2415c;Dbxref=EnsemblGenomes-Gn:Rv2415c,EnsemblGenomes-Tr:CCP45206,GOA:P71728,InterPro:IPR000445,InterPro:IPR003583,InterPro:IPR004509,InterPro:IPR010994,InterPro:IPR019554,UniProtKB/TrEMBL:P71728,NCBI_GP:CCP45206.1;Name=CCP45206.1;Note=Rv2415c%2C (MTCY253.05)%2C len: 297 aa. Hypothetical protein%2C with some similarity in C-terminal part to comE operon proteins 1 e.g. Q9EU10|come|COME4|COME1|COME2|COME3 come protein (a competence protein with DNA-binding activity) from Neisseria gonorrhoeae (99 aa)%2C FASTA scores: opt: 190%2C E(): 0.0032%2C (49.2%25 identity in 61 aa overlap)%3B Q9JYB8|NMB1657 from Neisseria meningitidis (205 aa) FASTA scores: opt: 191%2C E(): 0.0052%2C (49.2%25 identity in 61 aa overlap)%3B CME1_BACSU|P39694 come operon protein 1 from Bacillus subtilis (205 aa)%2C FASTA scores%2C opt: 181%2C E(): 0.017 (29.8%25 identity in 218 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2415c;product=Conserved hypothetical protein;protein_id=CCP45206.1;transl_table=11
AL123456.3	EMBL	gene	2714124	2715332	.	-	.	ID=gene-Rv2416c;Name=eis;gbkey=Gene;gene=eis;gene_biotype=protein_coding;locus_tag=Rv2416c
AL123456.3	EMBL	CDS	2714124	2715332	.	-	0	ID=cds-CCP45207.1;Parent=gene-Rv2416c;Dbxref=EnsemblGenomes-Gn:Rv2416c,EnsemblGenomes-Tr:CCP45207,GOA:P9WFK7,InterPro:IPR000182,InterPro:IPR003033,InterPro:IPR016181,InterPro:IPR022902,InterPro:IPR025559,PDB:3R1K,PDB:3RYO,PDB:3SXO,PDB:3UY5,NCBI_GP:CCP45207.1;Name=CCP45207.1;Note=Rv2416c%2C (MTCY253.04)%2C len: 402 aa. Eis%2C enhanced intracellular survival gene (see citations below). Conserved hypothetical protein%2C contains GNAT (Gcn5-related N-acetyltransferase) domain in N-terminal part%2C similar to Q9F309|SCC80.10 hypothetical 44.7 KDA protein from Streptomyces coelicolor (413 aa)%2C FASTA scores: opt: 382%2CE(): 1e-16%2C (31.45%25 identity in 407 aa overlap)%3B Q9K4F4|SCD66.23 conserved hypothetical protein from Streptomyces coelicolor (418 aa)%2C FASTA scores: opt: 238%2CE(): 1.3e-07%2C (36.5%25 identity in 364 aa overlap): and Q54238|G1139577|ORF5 hypothetical protein from Streptomyces griseus (416 aa)%2C FASTA scores: opt: 237%2C E(): 1.5e-07%2C(34.0 identity in 423 aa overlap). Start changed since first submission (- 6 aa) (see Dahl et al.%2C 2001%3B Wei et al.%2C 2000%3B Vetting et al. 2005).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eis;locus_tag=Rv2416c;product=Enhanced intracellular survival protein Eis%2CGCN5-related N-acetyltransferase;protein_id=CCP45207.1;transl_table=11
AL123456.3	EMBL	gene	2715472	2716314	.	-	.	ID=gene-Rv2417c;Name=Rv2417c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2417c
AL123456.3	EMBL	CDS	2715472	2716314	.	-	0	ID=cds-CCP45208.1;Parent=gene-Rv2417c;Dbxref=EnsemblGenomes-Gn:Rv2417c,EnsemblGenomes-Tr:CCP45208,GOA:P9WP05,InterPro:IPR003797,NCBI_GP:CCP45208.1;Name=CCP45208.1;Note=Rv2417c%2C (MTCY253.03)%2C len: 280 aa. Conserved protein%2C highly similar to Q9RDL7|SCC123.07c hypothetical 29.2 KDA protein from Streptomyces coelicolor (281 aa)%2CFASTA scores: opt: 579%2C E(): 3.6e-27%2C (38.3%25 identity in 274 aa overlap). Also some similarity with DEGV proteins or hypothetical proteins from other organisms%2C e.g. Q9RSY3|DR1986 from Deinococcus radiodurans (281 aa)%2C FASTA scores: opt: 393%2C E(): 3.4e-16%2C (31.0%25 identity in 280 aa overlap)%3B P32436|DEGV_BACSU from Bacillus subtilis (281 aa)%2C FASTA scores: opt: 365%2C E(): 1.5e-14%2C (27.8%25 identity in 284 aa overlap)%3B BAB41937|BAB46307|SA0704|SAV0749 Conserved hypothetical protein from Staphylococcus aureus strain Mu50 and N315 (288 aa)%2C FASTA scores: opt: 371%2C E(): 7e-15%2C (28.85%25 identity in 281 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2417c;product=Conserved protein;protein_id=CCP45208.1;transl_table=11
AL123456.3	EMBL	repeat_region	2716315	2716391	.	-	.	ID=id-AL123456.3:2716315..2716391;Note=77 bp Mycobacterial Interspersed Repetitive Unit%2CClass I;gbkey=repeat_region
AL123456.3	EMBL	gene	2716395	2717138	.	-	.	ID=gene-Rv2418c;Name=Rv2418c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2418c
AL123456.3	EMBL	CDS	2716395	2717138	.	-	0	ID=cds-CCP45209.1;Parent=gene-Rv2418c;Dbxref=EnsemblGenomes-Gn:Rv2418c,EnsemblGenomes-Tr:CCP45209,GOA:P71725,InterPro:IPR013831,UniProtKB/TrEMBL:P71725,NCBI_GP:CCP45209.1;Name=CCP45209.1;Note=Rv2418c%2C (MTCY253.02)%2C len: 247 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2418c;product=Unknown protein;protein_id=CCP45209.1;transl_table=11
AL123456.3	EMBL	gene	2717128	2717799	.	-	.	ID=gene-Rv2419c;Name=gpgP;gbkey=Gene;gene=gpgP;gene_biotype=protein_coding;locus_tag=Rv2419c
AL123456.3	EMBL	CDS	2717128	2717799	.	-	0	ID=cds-CCP45210.1;Parent=gene-Rv2419c;Dbxref=EnsemblGenomes-Gn:Rv2419c,EnsemblGenomes-Tr:CCP45210,GOA:P9WIC7,InterPro:IPR001345,InterPro:IPR013078,InterPro:IPR029033,NCBI_GP:CCP45210.1;Name=CCP45210.1;Note=Rv2419c%2C (MTCY428.28-MTCY253.01)%2C len: 223 aa. gpgP%2Cglucosyl-3-phosphoglycerate phosphatase (See Mendes et al.%2C2011). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature. Belongs to the phosphoglycerate mutase family. Enzyme activity inhibited by Co2+ and Cu2+ (See Mendes et al.%2C 2011).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gpgP;inference=protein motif:PROSITE:PS00175;locus_tag=Rv2419c;product=Glucosyl-3-phosphoglycerate phosphatase GpgP;protein_id=CCP45210.1;transl_table=11
AL123456.3	EMBL	gene	2717796	2718176	.	-	.	ID=gene-Rv2420c;Name=Rv2420c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2420c
AL123456.3	EMBL	CDS	2717796	2718176	.	-	0	ID=cds-CCP45211.1;Parent=gene-Rv2420c;Dbxref=EnsemblGenomes-Gn:Rv2420c,EnsemblGenomes-Tr:CCP45211,GOA:O86327,InterPro:IPR004394,InterPro:IPR025656,PDB:4WCW,UniProtKB/TrEMBL:O86327,NCBI_GP:CCP45211.1;Name=CCP45211.1;Note=Rv2420c%2C (MTCY428.27)%2C len: 126 aa. Conserved hypothetical protein%2C equivalent to Q9CBZ9|ML1453 hypothetical protein from Mycobacterium leprae (129 aa)%2CFASTA scores: opt: 681%2C E(): 1.6e-38%2C (87.0%25 identity in 123 aa overlap). Also highly similar to Q9RDK9|SCC123.15c hypothetical protein from Streptomyces coelicolor (148 aa)%2CFASTA scores: opt: 447%2C E(): 5.8e-23%2C (52.7%25 identity in 129 aa overlap)%3B and similar to others e.g. P54457|YQEL_BACSU hypothetical protein from Bacillus subtilis (118 aa)%2C FASTA scores: opt: 318%2C E(): 1.8e-14%2C(37.3%25 identity in 110 aa overlap)%3B Q9KD89|BH1328 hypothetical protein from Bacillus halodurans (117 aa)%2CFASTA scores: opt: 296%2C E(): 5.1e-13%2C (37.6%25 identity in 109 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2420c;product=Conserved hypothetical protein;protein_id=CCP45211.1;transl_table=11
AL123456.3	EMBL	gene	2718173	2718808	.	-	.	ID=gene-Rv2421c;Name=nadD;gbkey=Gene;gene=nadD;gene_biotype=protein_coding;locus_tag=Rv2421c
AL123456.3	EMBL	CDS	2718173	2718808	.	-	0	ID=cds-CCP45212.1;Parent=gene-Rv2421c;Dbxref=EnsemblGenomes-Gn:Rv2421c,EnsemblGenomes-Tr:CCP45212,GOA:P9WJJ5,InterPro:IPR004821,InterPro:IPR005248,InterPro:IPR014729,NCBI_GP:CCP45212.1;Name=CCP45212.1;Note=Rv2421c%2C (MT2494%2C MTCY428.26)%2C len: 211 aa. Probable nadD%2C nicotinate-nucleotide adenylyltransferase %2Cequivalent to Q9CBZ8|NADD_MYCLE|ML1454 probable nicotinate-nucleotide adenylyltransferase from Mycobacterium leprae (214 aa)%2C FASTA scores: opt: 1125%2CE(): 2.7e-66%2C (80.2%25 identity in 212 aa overlap). Also highly similar to Q9RDK7|NADD_STRCO probable nicotinate-nucleotide adenylyltransferase from Streptomyces coelicolor (188 aa)%2C FASTA scores: opt: 855%2C E(): 9.8e-49%2C(66.5%25 identity in 194 aa overlap)%3B and similar to others e.g. P54455|NADD_BACSU from Bacillus subtilis (189 aa)%2CFASTA scores: opt: 351%2C E(): 7e-16%2C (36.1%25 identity in 191 aa overlap)%3B etc. Belongs to the NadD family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nadD;locus_tag=Rv2421c;product=Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase);protein_id=CCP45212.1;transl_table=11
AL123456.3	EMBL	gene	2719083	2719355	.	+	.	ID=gene-Rv2422;Name=Rv2422;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2422
AL123456.3	EMBL	CDS	2719083	2719355	.	+	0	ID=cds-CCP45213.1;Parent=gene-Rv2422;Dbxref=EnsemblGenomes-Gn:Rv2422,EnsemblGenomes-Tr:CCP45213,UniProtKB/TrEMBL:P71926,NCBI_GP:CCP45213.1;Name=CCP45213.1;Note=Rv2422%2C (MTCY428.25c)%2C len: 90 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2422;product=Hypothetical protein;protein_id=CCP45213.1;transl_table=11
AL123456.3	EMBL	gene	2719597	2720643	.	+	.	ID=gene-Rv2423;Name=Rv2423;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2423
AL123456.3	EMBL	CDS	2719597	2720643	.	+	0	ID=cds-CCP45214.1;Parent=gene-Rv2423;Dbxref=EnsemblGenomes-Gn:Rv2423,EnsemblGenomes-Tr:CCP45214,InterPro:IPR029063,UniProtKB/TrEMBL:P71925,NCBI_GP:CCP45214.1;Name=CCP45214.1;Note=Rv2423%2C (MTCY428.24c)%2C len: 348 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2423;product=Hypothetical protein;protein_id=CCP45214.1;transl_table=11
AL123456.3	EMBL	repeat_region	2720644	2720656	.	+	.	ID=id-AL123456.3:2720644..2720656;Note=13 bp inverted repeat%2C GCAGTCG(C)AAAAG%2C at the left end of IS1558;gbkey=repeat_region
AL123456.3	EMBL	gene	2720776	2721777	.	-	.	ID=gene-Rv2424c;Name=Rv2424c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2424c
AL123456.3	EMBL	CDS	2720776	2721777	.	-	0	ID=cds-CCP45215.1;Parent=gene-Rv2424c;Dbxref=EnsemblGenomes-Gn:Rv2424c,EnsemblGenomes-Tr:CCP45215,GOA:P71924,InterPro:IPR002525,InterPro:IPR003346,UniProtKB/TrEMBL:P71924,NCBI_GP:CCP45215.1;Name=CCP45215.1;Note=Rv2424c%2C (MTCY428.23)%2C len: 333 aa. Probable transposase for IS1558%2C similar to is element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa)%2C FASTA scores: opt: 1491%2C E(): 6.2e-87%2C (98.6%25 identity in 221 aa overlap)%3B P19780|YIS1_STRCO hypothetical insertion element IS110 from Streptomyces coelicolor (45 aa)%2C FASTA scores: opt: 203%2C E(): 1.7e-05%3B (27.3%25 identity in 238 aa overlap)%3B etc. Contains PS01159 WW/rsp5/WWP domain signature.;gbkey=CDS;inference=protein motif:PROSITE:PS01159;locus_tag=Rv2424c;product=Probable transposase;protein_id=CCP45215.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2720779	2721777	.	-	.	ID=id-Rv2424c;Note=IS1558-2%2C len: 999 nt. Insertion sequence IS1558.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1558-2
AL123456.3	EMBL	repeat_region	2721844	2721856	.	-	.	ID=id-AL123456.3:2721844..2721856;Note=13 bp inverted repeat%2C GCAGTCG(T)AAAAG%2C at the right end of IS1558;gbkey=repeat_region
AL123456.3	EMBL	gene	2721866	2723308	.	-	.	ID=gene-Rv2425c;Name=Rv2425c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2425c
AL123456.3	EMBL	CDS	2721866	2723308	.	-	0	ID=cds-CCP45216.1;Parent=gene-Rv2425c;Dbxref=EnsemblGenomes-Gn:Rv2425c,EnsemblGenomes-Tr:CCP45216,InterPro:IPR002035,InterPro:IPR008912,InterPro:IPR011195,UniProtKB/TrEMBL:P71923,NCBI_GP:CCP45216.1;Name=CCP45216.1;Note=Rv2425c%2C (MTCY428.22)%2C len: 480 aa. Hypothetical protein%3B C-terminal half shares similarity to other unknown conserved proteins e.g. Q53065 hypothetical 24.3 KDA protein from Rhodococcus erythropolis (219 aa)%2C FASTA scores: opt: 398%2C E(): 9.9e-17%2C (34.15%25 identity in 202 aa overlap)%3B C-terminus of O27843|MTH1815 conserved protein from Methanothermobacter thermautotrophicus (346 aa)%2C FASTA scores: opt: 341%2C E(): 3.7e-13%2C (31.35%25 identity in 233 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2425c;product=Conserved hypothetical protein;protein_id=CCP45216.1;transl_table=11
AL123456.3	EMBL	gene	2723308	2724183	.	-	.	ID=gene-Rv2426c;Name=Rv2426c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2426c
AL123456.3	EMBL	CDS	2723308	2724183	.	-	0	ID=cds-CCP45217.1;Parent=gene-Rv2426c;Dbxref=EnsemblGenomes-Gn:Rv2426c,EnsemblGenomes-Tr:CCP45217,GOA:P71922,InterPro:IPR003593,InterPro:IPR011704,InterPro:IPR027417,UniProtKB/TrEMBL:P71922,NCBI_GP:CCP45217.1;Name=CCP45217.1;Note=Rv2426c%2C (MTCY428.21)%2C len: 291 aa. Conserved hypothetical protein%2C highly similar to others e.g. Q51326|ORF4 from Pseudomonas carboxydovorans (295 aa)%2CFASTA scores: opt: 853%2C E(): 3.7e-43%2C (48.75%25 identity in 277 aa overlap)%3B BAB47746|MLR0088 from Rhizobium loti (309 aa)%2C FASTA scores: opt :809%2C E(): 1.5e-40%2C (46.5%25 identity in 291 aa overlap)%3B Q9Y9R8|APE2220 from Aeropyrum pernix (297 aa)%2C FASTA scores: opt: 763%2C E(): 7.4e-38%2C (47.1%25 identity in 261 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2426c;product=Conserved hypothetical protein;protein_id=CCP45217.1;transl_table=11
AL123456.3	EMBL	gene	2724230	2725477	.	-	.	ID=gene-Rv2427c;Name=proA;gbkey=Gene;gene=proA;gene_biotype=protein_coding;locus_tag=Rv2427c
AL123456.3	EMBL	CDS	2724230	2725477	.	-	0	ID=cds-CCP45218.1;Parent=gene-Rv2427c;Dbxref=EnsemblGenomes-Gn:Rv2427c,EnsemblGenomes-Tr:CCP45218,GOA:P9WHV1,InterPro:IPR000965,InterPro:IPR012134,InterPro:IPR015590,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR020593,NCBI_GP:CCP45218.1;Name=CCP45218.1;Note=Rv2427c%2C (MTCY428.20)%2C len: 415 aa. Probable proA%2Cgamma-glutamyl phosphate reductase protein%2C equivalent to Q9CBZ7|ML1458|PROA [gamma]-glutamyl phosphate reductase from Mycobacterium leprae (409 aa)%2C FASTA scores: opt: 2120%2C E(): 7.4e-118%2C (81.9%25 identity in 409 aa overlap). Also highly similar or similar to other gamma-glutamyl phosphate reductases proteins (GPR) e.g. Q9RDK1|PROA from Streptomyces coelicolor (428 aa)%2C FASTA scores: opt: 1073%2CE(): 4.6e-56%2C (60.4%25 identity in 429 aa overlap)%3B P45638|PROA_CORGL from Corynebacterium glutamicum (432 aa)%2CFASTA scores: opt: 993%2C E(): 2.4e-51%2C (58.5%25 identity in 417 aa overlap)%3B P96489|PROA_STRTR gamma-glutamyl phosphate reductase from Streptococcus thermophilus (416 aa)%2C FASTA scores: opt: 863%2C E(): 1.1e-43%2C (49.15%25 identity in 413 aa overlap)%3B etc. Belongs to the gamma-glutamyl phosphate reductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=proA;locus_tag=Rv2427c;product=Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase);protein_id=CCP45218.1;transl_table=11
AL123456.3	EMBL	pseudogene	2725571	2726087	.	-	.	ID=gene-Rv2427A;Name=oxyR';gbkey=Gene;gene=oxyR';gene_biotype=pseudogene;locus_tag=Rv2427A;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	2725571	2726087	.	-	0	ID=cds-Rv2427A;Parent=gene-Rv2427A;Note=Rv2427A%2C Pseudogene oxyR'%2C inactivated by multiple mutations%3B identical to sequence in u16243 (see Deretic et al.%2C 1995).;gbkey=CDS;gene=oxyR';locus_tag=Rv2427A;product=Transcriptional regulator OxyR'%2C pseudogene;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	2726193	2726780	.	+	.	ID=gene-Rv2428;Name=ahpC;gbkey=Gene;gene=ahpC;gene_biotype=protein_coding;locus_tag=Rv2428
AL123456.3	EMBL	CDS	2726193	2726780	.	+	0	ID=cds-CCP45220.1;Parent=gene-Rv2428;Dbxref=EnsemblGenomes-Gn:Rv2428,EnsemblGenomes-Tr:CCP45220,GOA:P9WQB7,InterPro:IPR000866,InterPro:IPR012336,InterPro:IPR024706,PDB:2BMX,NCBI_GP:CCP45220.1;Name=CCP45220.1;Note=Rv2428%2C (MTCY428.18c)%2C len: 195 aa. AhpC%2C alkyl hydroperoxide reductase C (see citations below)%2C equivalent to other alkyl hydroperoxide reductases C mycobacterial proteins e.g. Q9CBF5|AHPC|ML2042 alkyl hydroperoxide reductase from Mycobacterium leprae (195 aa) FASTA scores: opt: 1183%2C E(): 2.6e-72%2C (88.20%25 identity in 195 aa overlap)%3B O87323|AHPC from Mycobacterium marinum (195 aa)%2CFASTA scores: opt: 1215%2C E(): 1.9e-74%2C (90.8%25 identity in 195 aa overlap)%3B Q57413|AHPC|AVI-3 from Mycobacterium avium (195 aa)%2C FASTA scores: opt: 1201%2C E(): 1.6e-73%2C (90.25%25 identity in 195 aa overlap). Also highly similar to others from other organisms e.g. Q9FBP5|AHPC alkyl hydroperoxide reductase from Streptomyces coelicolor (184 aa)%2C FASTA scores: opt: 768%2C E(): 1.7e-44%2C (62.45%25 identity in 189 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ahpC;locus_tag=Rv2428;product=Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C);protein_id=CCP45220.1;transl_table=11
AL123456.3	EMBL	gene	2726806	2727339	.	+	.	ID=gene-Rv2429;Name=ahpD;gbkey=Gene;gene=ahpD;gene_biotype=protein_coding;locus_tag=Rv2429
AL123456.3	EMBL	CDS	2726806	2727339	.	+	0	ID=cds-CCP45221.1;Parent=gene-Rv2429;Dbxref=EnsemblGenomes-Gn:Rv2429,EnsemblGenomes-Tr:CCP45221,GOA:P9WQB5,InterPro:IPR003779,InterPro:IPR004674,InterPro:IPR004675,InterPro:IPR029032,PDB:1GU9,PDB:1KNC,PDB:1LW1,PDB:1ME5,NCBI_GP:CCP45221.1;Name=CCP45221.1;Note=Rv2429%2C (MTCY428.17c)%2C len: 177 aa. AhpD%2C alkyl hydroperoxide reductase%2C similar to other alkyl hydroperoxide reductases D proteins e.g. Q9RN73|AHPD from Streptomyces coelicolor (178 aa)%2C FASTA scores: opt: 611%2CE(): 1.4e-33%2C (57.4%25 identity in 169 aa overlap)%3B Q50441|AHPD_MYCSM AHPD protein (fragment) from Mycobacterium smegmatis (52 aa)%2C FASTA score: opt:196.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ahpD;locus_tag=Rv2429;product=Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D);protein_id=CCP45221.1;transl_table=11
AL123456.3	EMBL	gene	2727336	2727920	.	-	.	ID=gene-Rv2430c;Name=PPE41;gbkey=Gene;gene=PPE41;gene_biotype=protein_coding;locus_tag=Rv2430c
AL123456.3	EMBL	CDS	2727336	2727920	.	-	0	ID=cds-CCP45222.1;Parent=gene-Rv2430c;Dbxref=EnsemblGenomes-Gn:Rv2430c,EnsemblGenomes-Tr:CCP45222,GOA:Q79FE1,InterPro:IPR000030,PDB:2G38,PDB:4KXR,UniProtKB/TrEMBL:Q79FE1,NCBI_GP:CCP45222.1;Name=CCP45222.1;Note=Rv2430c%2C (MTCY428.16)%2C len: 194 aa. PPE41%2C Member of the Mycobacterium tuberculosis PPE family similar to others e.g. AAK46014|Rv1745|MT1745 from Mycobacterium tuberculosis (385 aa) FASTA scores: opt: 389%2C E(): 1.2e-17%2C (35.95%25 identity in 192 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE41;locus_tag=Rv2430c;product=PPE family protein PPE41;protein_id=CCP45222.1;transl_table=11
AL123456.3	EMBL	gene	2727967	2728266	.	-	.	ID=gene-Rv2431c;Name=PE25;gbkey=Gene;gene=PE25;gene_biotype=protein_coding;locus_tag=Rv2431c
AL123456.3	EMBL	CDS	2727967	2728266	.	-	0	ID=cds-CCP45223.1;Parent=gene-Rv2431c;Dbxref=EnsemblGenomes-Gn:Rv2431c,EnsemblGenomes-Tr:CCP45223,InterPro:IPR000084,PDB:4KXR,UniProtKB/TrEMBL:I6X486,NCBI_GP:CCP45223.1;Name=CCP45223.1;Note=Rv2431c%2C (MTCY428.15)%2C len: 99 aa. PE25%2C Member of the Mycobacterium tuberculosis PE family (see Brennan %26 Delogu 2002)%2C similar to others e.g. AAK47158|MT2839 from Mycobacterium tuberculosis (275 aa) FASTA scores: opt: 194%2CE(): 2.5e-06%2C (40.0%25 identity in 95 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE25;locus_tag=Rv2431c;product=PE family protein PE25;protein_id=CCP45223.1;transl_table=11
AL123456.3	EMBL	gene	2728437	2728847	.	-	.	ID=gene-Rv2432c;Name=Rv2432c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2432c
AL123456.3	EMBL	CDS	2728437	2728847	.	-	0	ID=cds-CCP45224.1;Parent=gene-Rv2432c;Dbxref=EnsemblGenomes-Gn:Rv2432c,EnsemblGenomes-Tr:CCP45224,UniProtKB/TrEMBL:P71917,NCBI_GP:CCP45224.1;Name=CCP45224.1;Note=Rv2432c%2C (MTCY428.14)%2C len: 136 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2432c;product=Hypothetical protein;protein_id=CCP45224.1;transl_table=11
AL123456.3	EMBL	gene	2728844	2729134	.	-	.	ID=gene-Rv2433c;Name=Rv2433c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2433c
AL123456.3	EMBL	CDS	2728844	2729134	.	-	0	ID=cds-CCP45225.1;Parent=gene-Rv2433c;Dbxref=EnsemblGenomes-Gn:Rv2433c,EnsemblGenomes-Tr:CCP45225,UniProtKB/TrEMBL:P71916,NCBI_GP:CCP45225.1;Name=CCP45225.1;Note=Rv2433c%2C (MTCY428.13)%2C len: 96 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2433c;product=Hypothetical protein;protein_id=CCP45225.1;transl_table=11
AL123456.3	EMBL	gene	2729115	2730560	.	-	.	ID=gene-Rv2434c;Name=Rv2434c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2434c
AL123456.3	EMBL	CDS	2729115	2730560	.	-	0	ID=cds-CCP45226.1;Parent=gene-Rv2434c;Dbxref=EnsemblGenomes-Gn:Rv2434c,EnsemblGenomes-Tr:CCP45226,GOA:P71915,InterPro:IPR000595,InterPro:IPR006685,InterPro:IPR010920,InterPro:IPR014710,InterPro:IPR016846,InterPro:IPR018490,UniProtKB/TrEMBL:P71915,NCBI_GP:CCP45226.1;Name=CCP45226.1;Note=Rv2434c%2C (MTCY428.12)%2C len: 481 aa. Probable conserved transmembrane protein%2C with some similarity to BAB48444|MLR0973 probable integral membrane protein from Rhizobium loti (410 aa)%2C FASTA scores: opt: 298%2C E(): 4.1e-11%2C (27.25%25 identity in 389 aa overlap)%3B and also similarity with other hypothetical proteins and/or putative integral membrane proteins.;gbkey=CDS;locus_tag=Rv2434c;product=Probable conserved transmembrane protein;protein_id=CCP45226.1;transl_table=11
AL123456.3	EMBL	gene	2730557	2732749	.	-	.	ID=gene-Rv2435c;Name=Rv2435c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2435c
AL123456.3	EMBL	CDS	2730557	2732749	.	-	0	ID=cds-CCP45227.1;Parent=gene-Rv2435c;Dbxref=EnsemblGenomes-Gn:Rv2435c,EnsemblGenomes-Tr:CCP45227,GOA:P71914,InterPro:IPR001054,InterPro:IPR003660,InterPro:IPR029787,UniProtKB/TrEMBL:P71914,NCBI_GP:CCP45227.1;Name=CCP45227.1;Note=Rv2435c%2C (MTCY428.11)%2C len: 730 aa. Probable cyclase (adenylyl- or guanylyl-cyclase%3B EC 4.6.1.1 or 4.6.1.2 respectively)%3B C-terminal domain (aa 500-730) similar to domain at C-terminus of a series of adenylate/guanylate cyclases e.g. O30820|CYA AAK45931|MT1661 from Mycobacterium tuberculosis (443 aa) FASTA scores: opt: 446%2C E(): 1.3e-19%2C(30.55%25 identity in 301 aa overlap)%3B BAB50179|MLL3242 cyclase (adenylyl or guanylyl) from Rhizobium loti (356 aa)%2C FASTA scores: opt: 372%2C E(): 3.4e-15%2C (28.75%25 identity in 219 aa overlap)%3B etc. Belongs to adenylyl cyclase class-4/guanylyl cyclase family.;gbkey=CDS;locus_tag=Rv2435c;product=Probable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-);protein_id=CCP45227.1;transl_table=11
AL123456.3	EMBL	gene	2733230	2734144	.	+	.	ID=gene-Rv2436;Name=rbsK;gbkey=Gene;gene=rbsK;gene_biotype=protein_coding;locus_tag=Rv2436
AL123456.3	EMBL	CDS	2733230	2734144	.	+	0	ID=cds-CCP45228.1;Parent=gene-Rv2436;Dbxref=EnsemblGenomes-Gn:Rv2436,EnsemblGenomes-Tr:CCP45228,GOA:P71913,InterPro:IPR002139,InterPro:IPR011611,InterPro:IPR029056,PDB:3GO6,PDB:3GO7,UniProtKB/TrEMBL:P71913,NCBI_GP:CCP45228.1;Name=CCP45228.1;Note=Rv2436%2C (MTCY428.10c)%2C len: 304 aa. Probable rbsK%2Cribokinase%2C similar to others e.g. Q9RZ99|DRA0055 from Deinococcus radiodurans (300 aa) FASTA scores: opt: 485%2CE(): 9.1e-21%2C (44.55%25 identity in 301 aa overlap)%3B P36945|P96733|RBSK_BACSU from Bacillus subtilis (293 aa)%2CFASTA scores: opt: 398%2C E(): 8.5e-16%2C (36.35%25 identity in 297 aa overlap)%3B P05054|RBSK_ECOLI|B3752|Z5253|ECS4694 from Escherichia coli strain K12 (309 aa)%2C FASTA scores: opt: 387%2C E(): 3.8e-15%2C (34.7%25 identity in 314 aa overlap)%3B etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1. Belongs to the PFKB family of carbohydrate kinases.;gbkey=CDS;gene=rbsK;inference=protein motif:PROSITE:PS00583;locus_tag=Rv2436;product=Ribokinase RbsK;protein_id=CCP45228.1;transl_table=11
AL123456.3	EMBL	gene	2734376	2734795	.	+	.	ID=gene-Rv2437;Name=Rv2437;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2437
AL123456.3	EMBL	CDS	2734376	2734795	.	+	0	ID=cds-CCP45229.1;Parent=gene-Rv2437;Dbxref=EnsemblGenomes-Gn:Rv2437,EnsemblGenomes-Tr:CCP45229,GOA:P71912,InterPro:IPR007318,UniProtKB/TrEMBL:P71912,NCBI_GP:CCP45229.1;Name=CCP45229.1;Note=Rv2437%2C (MTCY428.09c)%2C len: 139 aa. Conserved transmembrane protein%2C with some similarity to conserved hypothetical proteins e.g. O06539|RV1139C|MTCI65.06c from Mycobacterium tuberculosis (166 aa)%3B AAK45430|MT1172 from Mycobacterium tuberculosis (124 aa)%2C FASTA scores: opt: 166%2C E(): 0.00013%2C (35.7%25 identity in 112 aa overlap)%3B BAB48937|Mlr1600 from Rhizobium loti (222 aa)%2C FASTA scores: opt: 163 %2CE(): 0.00033%2C (28.1%25 identity in 121 aa overlap)%3B etc. Contains membrane spanning regions.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2437;product=Conserved transmembrane protein;protein_id=CCP45229.1;transl_table=11
AL123456.3	EMBL	gene	2734792	2736831	.	-	.	ID=gene-Rv2438c;Name=nadE;gbkey=Gene;gene=nadE;gene_biotype=protein_coding;locus_tag=Rv2438c
AL123456.3	EMBL	CDS	2734792	2736831	.	-	0	ID=cds-CCP45230.1;Parent=gene-Rv2438c;Dbxref=EnsemblGenomes-Gn:Rv2438c,EnsemblGenomes-Tr:CCP45230,GOA:P9WJJ3,InterPro:IPR003010,InterPro:IPR014445,InterPro:IPR014729,InterPro:IPR022310,PDB:3DLA,PDB:3SDB,PDB:3SEQ,PDB:3SEZ,PDB:3SYT,PDB:3SZG,NCBI_GP:CCP45230.1;Name=CCP45230.1;Note=Rv2438c%2C (MT2513%2C MTCY428.08)%2C len: 679 aa. NadE%2Cglutamine-dependent NAD(+) synthetase (see citation below)%2Cequivalent to Q9CBZ6|NADE_MYCLE|ML1463 Glutamine-dependent NAD(+) synthetase from Mycobacterium leprae (680 aa)%2C FASTA scores: opt: 3877%2C E(): 0. Also similar to others e.g. O83759|NADE_TREPA|TP0780 from Treponema pallidum (679 aa)%2CFASTA scores: opt: 543%2C E(): 1.1e-25%3B O74940|NADE_SCHPO|SPCC553.02 from Schizosaccharomyces pombe (Fission yeast) (700 aa)%2C FASTA scores: opt: 354%2C E(): 4.7e-14 %3B P38795|NADE_YEAST|YHR074W from Saccharomyces cerevisiae (Baker's yeast) (714 aa)%2C FASTA scores: opt: 339%2C E(): 4e-13%3B etc. Contains PS00591 Glycosyl hydrolases family 10 active site. Belongs to the NAD synthetase family in the C-terminal section. N-terminus shorter since first submission.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nadE;inference=protein motif:PROSITE:PS00591;locus_tag=Rv2438c;product=Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]);protein_id=CCP45230.1;transl_table=11
AL123456.3	EMBL	gene	2736709	2736987	.	+	.	ID=gene-Rv2438A;Name=Rv2438A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2438A
AL123456.3	EMBL	CDS	2736709	2736987	.	+	0	ID=cds-CCP45231.1;Parent=gene-Rv2438A;Dbxref=EnsemblGenomes-Gn:Rv2438A,EnsemblGenomes-Tr:CCP45231,UniProtKB/TrEMBL:Q79FD9,NCBI_GP:CCP45231.1;Name=CCP45231.1;Note=Rv2438A%2C len: 92 aa. Conserved hypothetical protein%2Cshowing few similarity with various enzymes e.g. part of O83441|VAA1_TREPA|ATPA1|TP0426 V-type ATP synthase alpha chain 1 from Treponema pallidum (589 aa)%2C FASTA scores: opt: 110%2C E(): 1.5%2C (40.3%25 identity in 72 aa overlap)%3B N-terminus of O95178|NIGM_HUMAN NADH-ubiquinone oxidoreductase AGGG subunit precursor from Homo sapiens (105 aa)%2C FASTA scores: opt: 109%2C E(): 1.5%2C (35.5%25 identity in 62 aa overlap)%3B N-terminus of Q9HJ76|TA1096 probable glycerol kinase from Thermoplasma acidophilum (488 aa)%3B etc.;gbkey=CDS;locus_tag=Rv2438A;product=Conserved hypothetical protein;protein_id=CCP45231.1;transl_table=11
AL123456.3	EMBL	gene	2737117	2738247	.	-	.	ID=gene-Rv2439c;Name=proB;gbkey=Gene;gene=proB;gene_biotype=protein_coding;locus_tag=Rv2439c
AL123456.3	EMBL	CDS	2737117	2738247	.	-	0	ID=cds-CCP45232.1;Parent=gene-Rv2439c;Dbxref=EnsemblGenomes-Gn:Rv2439c,EnsemblGenomes-Tr:CCP45232,GOA:P9WHU9,InterPro:IPR001048,InterPro:IPR001057,InterPro:IPR002478,InterPro:IPR005715,InterPro:IPR011529,InterPro:IPR015947,InterPro:IPR019797,NCBI_GP:CCP45232.1;Name=CCP45232.1;Note=Rv2439c%2C (MTCY428.07)%2C len: 376 aa. Probable proB%2Cglutamate 5-kinase protein (GK)%2C equivalent to Q9CBZ5|prob|ML1464 from Mycobacterium leprae (367 aa) FASTA scores: opt: 1937%2C E(): 1.1e-102%2C (84.4%25 identity in 366 aa overlap). Also highly similar to other glutamate 5-kinase proteins e.g. P46546|PROB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (369 aa)%2C FASTA scores: opt: 1241%2C E(): 3e-63%2C (54.35%25 identity in 368 aa overlap)%3B Q9ZG98|PROB_MEIRU glutamate 5-kinase from Meiothermus ruber (390 aa)%2C FASTA scores: opt: 825%2C E(): 1.2e-39%2C (45.05%25 identity in 353 aa overlap)%3B Q9RDJ9|prob|SCC123.25c from Streptomyces coelicolor (374 aa)%2C FASTA scores: opt: 1193%2CE(): 1.6e-60%2C (55.85%25 identity in 367 aa overlap)%3B etc. Contains PS00902 Glutamate 5-kinase signature. Belongs to the glutamate 5-kinase family.;gbkey=CDS;gene=proB;inference=protein motif:PROSITE:PS00902;locus_tag=Rv2439c;product=Probable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK);protein_id=CCP45232.1;transl_table=11
AL123456.3	EMBL	gene	2738247	2739686	.	-	.	ID=gene-Rv2440c;Name=obg;gbkey=Gene;gene=obg;gene_biotype=protein_coding;locus_tag=Rv2440c
AL123456.3	EMBL	CDS	2738247	2739686	.	-	0	ID=cds-CCP45233.1;Parent=gene-Rv2440c;Dbxref=EnsemblGenomes-Gn:Rv2440c,EnsemblGenomes-Tr:CCP45233,GOA:P9WMT1,InterPro:IPR006073,InterPro:IPR006074,InterPro:IPR006169,InterPro:IPR014100,InterPro:IPR015349,InterPro:IPR027417,NCBI_GP:CCP45233.1;Name=CCP45233.1;Note=Rv2440c%2C (MTCY428.06)%2C len: 479 aa. Probable obg%2Cnucleotide-binding protein%2C equivalent to Q9CBZ4|ML1465 GTP1/OBG-family GTP-binding protein from Mycobacterium leprae (478 aa)%2C FASTA scores: opt: 1328%2C E(): 8.4e-70%2C(58.9%25 identity in 479 aa overlap). Also highly similar to others e.g. P95722|OBG GTP-binding protein from Streptomyces coelicolor (478 aa)%2C FASTA scores: opt: 1311%2CE(): 8.2e-69%2C (60.7%25 identity in 476 aa overlap)%3B P20964|OBG_BACSU SPO0B-associated GTP-binding protein from Bacillus subtilis (428 aa)%2C FASTA scores: opt: 1006%2C E(): 3.9e-51%2C (42.9%25 identity in 436 aa overlap)%3B Q9KDK0|OBG|BH1213 GTP-binding protein involved in initiation of sporulation from Bacillus halodurans (427 aa)%2C FASTA scores: opt: 978%2C E(): 1.7e-49%2C (41.95%25 identity in 436 aa overlap)%3B etc. Highly similar (identical but shorter 5 aa) to AAK46813|MT2516 GTP-binding protein from Mycobacterium tuberculosis strain CDC1551 (484 aa)%2C FASTA scores: opt: 3205%2C E(): 7.9e-179%2C (100%25 identity in 479 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the GTP1/OBG family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=obg;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2440c;product=Probable GTP1/Obg-family GTP-binding protein Obg;protein_id=CCP45233.1;transl_table=11
AL123456.3	EMBL	gene	2739772	2740032	.	-	.	ID=gene-Rv2441c;Name=rpmA;gbkey=Gene;gene=rpmA;gene_biotype=protein_coding;locus_tag=Rv2441c
AL123456.3	EMBL	CDS	2739772	2740032	.	-	0	ID=cds-CCP45234.1;Parent=gene-Rv2441c;Dbxref=EnsemblGenomes-Gn:Rv2441c,EnsemblGenomes-Tr:CCP45234,GOA:P9WHB3,InterPro:IPR001684,InterPro:IPR018261,NCBI_GP:CCP45234.1;Name=CCP45234.1;Note=Rv2441c%2C (MTCY428.05)%2C len: 86 aa. rpmA%2C 50S ribosomal proteins L27%2C equivalent to Q9CBZ3|RL27_MYCLE from Mycobacterium leprae (88 aa)%2C FASTA scores: opt: 504%2CE(): 7.6e-28%2C (93.2%25 identity in 81 aa overlap). Also highly similar to others e.g. P95757|RL27_STRGR from Streptomyces griseus (85 aa)%2C FASTA scores: opt: 442%2C E(): 1.2e-23%2C (81.5%25 identity in 81 aa overlap)%3B etc. Contains PS00831 Ribosomal protein L27 signature. Belongs to the L27P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpmA;inference=protein motif:PROSITE:PS00831;locus_tag=Rv2441c;product=50S ribosomal protein L27 RpmA;protein_id=CCP45234.1;transl_table=11
AL123456.3	EMBL	gene	2740047	2740361	.	-	.	ID=gene-Rv2442c;Name=rplU;gbkey=Gene;gene=rplU;gene_biotype=protein_coding;locus_tag=Rv2442c
AL123456.3	EMBL	CDS	2740047	2740361	.	-	0	ID=cds-CCP45235.1;Parent=gene-Rv2442c;Dbxref=EnsemblGenomes-Gn:Rv2442c,EnsemblGenomes-Tr:CCP45235,GOA:P9WHC3,InterPro:IPR001787,InterPro:IPR018258,InterPro:IPR028909,NCBI_GP:CCP45235.1;Name=CCP45235.1;Note=Rv2442c%2C (MTCY428.04)%2C len: 104 aa. rplU%2C 50S ribosomal protein L21%2C equivalent to Q9CBZ2|RL21_MYCLE from Mycobacterium leprae (103 aa)%2C FASTA scores: opt: 579%2C E(): 4.8e-31%2C (91.1%25 identity in 102 aa overlap). Also highly similar to others e.g. P95756|RL21_STRGR from Streptomyces griseus (106 aa)%2C FASTA scores: opt: 362%2C E(): 5.4e-17%2C(56.0%25 identity in 100 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplU;locus_tag=Rv2442c;product=50S ribosomal protein L21 RplU;protein_id=CCP45235.1;transl_table=11
AL123456.3	EMBL	gene	2740709	2742184	.	+	.	ID=gene-Rv2443;Name=dctA;gbkey=Gene;gene=dctA;gene_biotype=protein_coding;locus_tag=Rv2443
AL123456.3	EMBL	CDS	2740709	2742184	.	+	0	ID=cds-CCP45236.1;Parent=gene-Rv2443;Dbxref=EnsemblGenomes-Gn:Rv2443,EnsemblGenomes-Tr:CCP45236,GOA:P71906,InterPro:IPR001991,UniProtKB/TrEMBL:P71906,NCBI_GP:CCP45236.1;Name=CCP45236.1;Note=Rv2443%2C (MTCY428.03c)%2C len: 491 aa. Probable dctA%2CC4-dicarboxylate-transport transmembrane protein%2C similar to other C4-dicarboxylate transport proteins e.g. AAK46817|MT2519 from Mycobacterium tuberculosis strain CDC1551 (491 aa)%3B Q9L1K8|SC6A11.12 putative sodium:dicarboxylate symporter from Streptomyces coelicolor (466 aa)%2C FASTA scores: opt: 1797%2C E(): 2.9e-98%2C (61.3%25 identity in 452 aa overlap)%3B Q9RRG7|DR2525 from Deinococcus radiodurans (463 aa)%3B P50334|DCTA_SALTY from Salmonella typhimurium (428 aa) FASTA scores: opt: 1241%2C E(): 1.3e-65%2C(47.2%25 identity in 415 aa overlap)%3B etc. Belongs to the sodium dicarboxylate symporter family (SDF) (DAACS family).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dctA;locus_tag=Rv2443;product=Probable C4-dicarboxylate-transport transmembrane protein DctA;protein_id=CCP45236.1;transl_table=11
AL123456.3	EMBL	gene	2742123	2744984	.	-	.	ID=gene-Rv2444c;Name=rne;gbkey=Gene;gene=rne;gene_biotype=protein_coding;locus_tag=Rv2444c
AL123456.3	EMBL	CDS	2742123	2744984	.	-	0	ID=cds-CCP45237.1;Parent=gene-Rv2444c;Dbxref=EnsemblGenomes-Gn:Rv2444c,EnsemblGenomes-Tr:CCP45237,GOA:P71905,InterPro:IPR003029,InterPro:IPR004659,InterPro:IPR012340,InterPro:IPR019307,InterPro:IPR022967,UniProtKB/TrEMBL:P71905,NCBI_GP:CCP45237.1;Name=CCP45237.1;Note=Rv2444c%2C (MTCY428.02)%2C len: 953 aa. Possible rne%2Cribonuclease E%2C highly similar to others e.g. Q9CBZ1|ML1468 possible ribonuclease from Mycobacterium leprae (924 aa)%2CFASTA scores: opt: 3713%2C E(): 2.4e-174%2C (74.2%25 identity in 966 aa overlap)%3B Q9SI08|AT2G04270 putative ribonuclease E from Arabidopsis thaliana (502 aa)%2C FASTA scores: opt: 674%2CE(): 7.5e-26%2C (31.2%25 identity in 410 aa overlap)%3B etc. Similar at C-terminal end to P21513|RNE_ECOLI|ams|HMP1|B1084 ribonuclease E (RNASE E) from Escherichia coli strain K12 (1061 aa)%2C FASTA scores: opt: 554%2C E(): 9.9e-20%2C (37.8%25 identity in 386 aa overlap). Also similar in medium part to several cytoplasmic axial filament proteins e.g. Q9HVU4|CAFA|PA4477 from Pseudomonas aeruginosa (485 aa)%2C FASTA scores: opt: 664%2C E(): 2.3e-25%2C(42.8%25 identity in 418 aa overlap)%3B etc. Equivalent to AAK46818 from Mycobacterium tuberculosis strain CDC1551 (621 aa) but longer 332 aa in N-terminal part. Seems to belong to the RNE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rne;locus_tag=Rv2444c;product=Possible ribonuclease E Rne;protein_id=CCP45237.1;transl_table=11
AL123456.3	EMBL	gene	2745314	2745724	.	-	.	ID=gene-Rv2445c;Name=ndkA;gbkey=Gene;gene=ndkA;gene_biotype=protein_coding;gene_synonym=ndk;locus_tag=Rv2445c
AL123456.3	EMBL	CDS	2745314	2745724	.	-	0	ID=cds-CCP45238.1;Parent=gene-Rv2445c;Dbxref=EnsemblGenomes-Gn:Rv2445c,EnsemblGenomes-Tr:CCP45238,GOA:P9WJH7,InterPro:IPR001564,PDB:1K44,PDB:4ANC,PDB:4AND,PDB:4ANE,NCBI_GP:CCP45238.1;Name=CCP45238.1;Note=Rv2445c%2C (MTV008.01c%2C MTCY428.01)%2C len: 136 aa. Probable ndkA (alternate gene name: ndk)%2C nucleoside diphosphate kinase%2C equivalent to Q9CBZ0|NDK|ML1469 from Mycobacterium leprae (136 aa)%2C FASTA scores: opt: 762%2C E(): 1.5e-42%2C (87.4%25 identity in 135 aa overlap)%3B and O85501|NDK from Mycobacterium smegmatis (139 aa)%2C FASTA scores: opt: 714%2C E(): 1.9e-39%2C (80.7%25 identity in 135 aa overlap). Also highly similar to others e.g. P50589|NDK_STRCO from Streptomyces coelicolor (137 aa)%2C FASTA scores: opt: 535%2C6.8e-28%2C (60.3%25 identity in 136 aa overlap)%3B O29491|NDK_ARCFU|AF0767 from Archaeoglobus fulgidus (151 aa)%2C FASTA scores: opt: 521%2C E(): 5.9e-27%2C (58.0%25 identity in 131 aa overlap)%3B P31103|NDK_BACSU from Bacillus subtilis (151 aa)%2C FASTA scores: opt: 515%2C E(): 1.4e-26%2C (56.5%25 identity in 131 aa overlap)%3B etc. Belongs to the NDK family. Ppk2|Rv3232c and NdkA|Rv2445c interact (See Sureka et al.%2C 2009).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ndkA;locus_tag=Rv2445c;product=Probable nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleoside-2-P kinase);protein_id=CCP45238.1;transl_table=11
AL123456.3	EMBL	gene	2745767	2746138	.	-	.	ID=gene-Rv2446c;Name=Rv2446c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2446c
AL123456.3	EMBL	CDS	2745767	2746138	.	-	0	ID=cds-CCP45239.1;Parent=gene-Rv2446c;Dbxref=EnsemblGenomes-Gn:Rv2446c,EnsemblGenomes-Tr:CCP45239,InterPro:IPR025327,UniProtKB/TrEMBL:O53173,NCBI_GP:CCP45239.1;Name=CCP45239.1;Note=Rv2446c%2C (MTV008.02c)%2C len: 123 aa. Probable conserved integral membrane protein%2C highly similar to Q9CBY9|ML1470 conserved membrane protein from Mycobacterium leprae (123 aa)%2C FASTA scores: opt: 468%2C E(): 6.7e-23%2C(66.65%25 identity in 108 aa overlap). Also similar to Q9L1G5|SCC88.24c putative membrane protein from Streptomyces coelicolor (118 aa)%2C FASTA scores: opt: 130%2CE(): 0.13%2C (37.2%25 identity in 86 aa overlap)%3B and some similarity to O06852|Y13070 hypothetical Streptomyces coelicolor gene also between fpgs and ndk genes (see citation below) (117 aa)%2C FASTA scores: opt: 128%2C E(): 0.17%2C (36.0%25 identity in 86 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2446c;product=Probable conserved integral membrane protein;protein_id=CCP45239.1;transl_table=11
AL123456.3	EMBL	gene	2746135	2747598	.	-	.	ID=gene-Rv2447c;Name=folC;gbkey=Gene;gene=folC;gene_biotype=protein_coding;locus_tag=Rv2447c
AL123456.3	EMBL	CDS	2746135	2747598	.	-	0	ID=cds-CCP45240.1;Parent=gene-Rv2447c;Dbxref=EnsemblGenomes-Gn:Rv2447c,EnsemblGenomes-Tr:CCP45240,GOA:I6Y0R5,InterPro:IPR001645,InterPro:IPR004101,InterPro:IPR013221,InterPro:IPR018109,UniProtKB/TrEMBL:I6Y0R5,NCBI_GP:CCP45240.1;Name=CCP45240.1;Note=Rv2447c%2C (MTV008.03c)%2C len: 487 aa. Probable folC%2Cfolylpolyglutamate synthase%2C equivalent to Q9CBY8|FOLC|ML1471 from Mycobacterium leprae (485 aa)%2CFASTA scores: opt: 2425%2C E(): 2.2e-134%2C (78.7%25 identity in 483 aa overlap). Also highly similar to others e.g. Q9L1G4|FPGS|O08416|Y13070 from Streptomyces coelicolor (444 aa)%2C FASTA scores: opt: 774%2C E(): 6.3e-38%2C (53.9%25 identity in 462 aa overlap)%3B P15925|FOLC_LACCA|FGS from Lactobacillus casei (428 aa)%2C FASTA scores: opt: 631%2C E(): 1.4e-29%2C (34.55%25 identity in 437 aa overlap)%3B Q05865|FOLC_BACSU from Bacillus subtilis (430 aa)%2C FASTA scores: opt: 421%2C E(): 2.6e-17%2C (32.9%25 identity in 383 aa overlap)%3B etc. Contains PS01012 Folylpolyglutamate synthase signature 2. Belongs to the folylpolyglutamate synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=folC;inference=protein motif:PROSITE:PS01012;locus_tag=Rv2447c;product=Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS);protein_id=CCP45240.1;transl_table=11
AL123456.3	EMBL	gene	2747595	2750225	.	-	.	ID=gene-Rv2448c;Name=valS;gbkey=Gene;gene=valS;gene_biotype=protein_coding;locus_tag=Rv2448c
AL123456.3	EMBL	CDS	2747595	2750225	.	-	0	ID=cds-CCP45241.1;Parent=gene-Rv2448c;Dbxref=EnsemblGenomes-Gn:Rv2448c,EnsemblGenomes-Tr:CCP45241,GOA:P9WFS9,InterPro:IPR001412,InterPro:IPR002300,InterPro:IPR002303,InterPro:IPR009008,InterPro:IPR009080,InterPro:IPR010978,InterPro:IPR013155,InterPro:IPR014729,InterPro:IPR019499,NCBI_GP:CCP45241.1;Name=CCP45241.1;Note=Rv2448c%2C (MTV008.04c)%2C len: 876 aa. Probable valS%2Cvalyl-tRNA synthetases%2C equivalent to Q9CBY7|VALS|ML1472 valyl-tRNA synthase from Mycobacterium leprae (886 aa)%2CFASTA scores: opt: 5181%2CE(): 0%2C (85.4%25 identity in 876 aa overlap). Also highly similar to others e.g. O06851|SYV_STRCO from Streptomyces coelicolor (874 aa)%2CFASTA scores: opt: 2470%2C E(): 1.6e-143%2C (60.45%25 identity in 880 aa overlap)%3B Q9X2D7|SYV_THEMA|VALS|TM1817 from Thermotoga maritima (865 aa)%2C FASTA scores: opt: 2418%2C E(): 2.4e-140%2C (44.2%25 identity in 891 aa overlap)%3B Q05873|SYV_BACSU|VALS from Bacillus subtilis (880 aa)%2CFASTA scores: opt: 2063%2C E(): 1.4e-118%2C (46.08%25 identity in 894 aa overlap)%3B etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Contains probable coiled-coil from aa 810 to 846. Belongs to class-I aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=valS;inference=protein motif:PROSITE:PS00178;locus_tag=Rv2448c;product=Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase);protein_id=CCP45241.1;transl_table=11
AL123456.3	EMBL	gene	2750313	2751572	.	-	.	ID=gene-Rv2449c;Name=Rv2449c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2449c
AL123456.3	EMBL	CDS	2750313	2751572	.	-	0	ID=cds-CCP45242.1;Parent=gene-Rv2449c;Dbxref=EnsemblGenomes-Gn:Rv2449c,EnsemblGenomes-Tr:CCP45242,GOA:O53176,InterPro:IPR005097,InterPro:IPR016040,NCBI_GP:CCP45242.1;Name=CCP45242.1;Note=Rv2449c%2C (MTV008.05c)%2C len: 419 aa. Conserved protein%2C highly similar to hypothetical proteins e.g. P95139|Rv2953|MTCY349.37c from M. tuberculosis (418 aa)%2CFASTA scores: opt: 1829%2C E(): 4.7e-103%2C (67.3%25 identity in 419 aa overlap)%3B AAK47353|MT3027 from Mycobacterium tuberculosis strain CDC1551 (418 aa)%2C FASTA score: opt: 1829%2C E(): 4.7e-103%2C (67.3 identity in 419 aa overlap)%3B Q9CD87|ML0129 from Mycobacterium leprae (418 aa)%2C FASTA scores: opt: 1727%2C E(): 6.8e-97%2C (65.45%25 identity in 414 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2449c;product=Conserved protein;protein_id=CCP45242.1;transl_table=11
AL123456.3	EMBL	gene	2751662	2752180	.	-	.	ID=gene-Rv2450c;Name=rpfE;gbkey=Gene;gene=rpfE;gene_biotype=protein_coding;locus_tag=Rv2450c
AL123456.3	EMBL	CDS	2751662	2752180	.	-	0	ID=cds-CCP45243.1;Parent=gene-Rv2450c;Dbxref=EnsemblGenomes-Gn:Rv2450c,EnsemblGenomes-Tr:CCP45243,GOA:O53177,InterPro:IPR010618,InterPro:IPR023346,PDB:4CGE,NCBI_GP:CCP45243.1;Name=CCP45243.1;Note=Rv2450c%2C (MTV008.06c)%2C len: 172 aa. Probable rpfE%2Cresuscitation-promoting factor (see Mukamolova et al.%2C1998)%2C similar to O86308|Z96935|MLRPF_1 RPF protein precursor from Micrococcus luteus (220 aa)%2C FASTA scores: opt: 291%2C E(): 3e-7%2C (48.75%25 identity in 80 aa overlap). C-terminus is similar to other Mycobacterial rpf proteins e.g. O05594|Rv1009|MTCI237.26|RPFB probable resuscitation-promoting factor from Mycobacterium tuberculosis (362 aa)%2C FASTA scores: opt: 344%2C E(): 1.4e-09%2C (42.85%25 identity in 147 aa overlap)%3B etc. C-terminal region similar to N-terminal region of Q9F2Q2|SCE41.06c putative secreted protein from Streptomyces coelicolor (244 aa)%2C FASTA scores: opt: 355%2CE(): 3.1e-10%2C (56.65%25 identity in 90 aa overlap). Also similar to Q9F2Q1|SCE41.07c putative secreted protein from Streptomyces coelicolor (near Q9F2Q2|SCE41.06c) (341 aa) FASTA scores: opt: 317%2C E(): 2.5e-08%2C (51.7%25 identity in 87 aa overlap). With Mycobacterium leprae%2C high similarity between the two corresponding C-terminal regions of two hypothetical proteins%2C Q9CD53|ML0240 (375 aa)%2C FASTA scores: opt: 339%2C E(): 2.5e-09%2C (59.15%25 identity in 93 aa overlap) and O33049|MLCB57.05c|ML2151 (174 aa)%2C FASTA scores: opt: 329%2C E(): 4e-09%2C (58.14%25 identity in 86 aa overlap). Contains a possible secretory signal sequence in N-terminus. Possible autocrine and/or paracrine bacterial growth factor or cytokine (see citations below). Interacts with RipA (see Hett et al.%2C 2007). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpfE;locus_tag=Rv2450c;product=Probable resuscitation-promoting factor RpfE;protein_id=CCP45243.1;transl_table=11
AL123456.3	EMBL	gene	2752262	2752660	.	+	.	ID=gene-Rv2451;Name=Rv2451;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2451
AL123456.3	EMBL	CDS	2752262	2752660	.	+	0	ID=cds-CCP45244.1;Parent=gene-Rv2451;Dbxref=EnsemblGenomes-Gn:Rv2451,EnsemblGenomes-Tr:CCP45244,GOA:O53178,UniProtKB/TrEMBL:O53178,NCBI_GP:CCP45244.1;Name=CCP45244.1;Note=Rv2451%2C (MTV008.07)%2C len: 132 aa. Hypothetical unknown pro-%2C ser-rich protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2451;product=Hypothetical proline and serine rich protein;protein_id=CCP45244.1;transl_table=11
AL123456.3	EMBL	gene	2752848	2752994	.	-	.	ID=gene-Rv2452c;Name=Rv2452c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2452c
AL123456.3	EMBL	CDS	2752848	2752994	.	-	0	ID=cds-CCP45245.1;Parent=gene-Rv2452c;Dbxref=EnsemblGenomes-Gn:Rv2452c,EnsemblGenomes-Tr:CCP45245,GOA:O53179,UniProtKB/TrEMBL:O53179,NCBI_GP:CCP45245.1;Name=CCP45245.1;Note=Rv2452c%2C (MTV008.08c)%2C len: 48 aa. Hypothetical unknown protein (see citation below).;gbkey=CDS;locus_tag=Rv2452c;product=Hypothetical protein;protein_id=CCP45245.1;transl_table=11
AL123456.3	EMBL	gene	2753018	2753623	.	-	.	ID=gene-Rv2453c;Name=mobA;gbkey=Gene;gene=mobA;gene_biotype=protein_coding;locus_tag=Rv2453c
AL123456.3	EMBL	CDS	2753018	2753623	.	-	0	ID=cds-CCP45246.1;Parent=gene-Rv2453c;Dbxref=EnsemblGenomes-Gn:Rv2453c,EnsemblGenomes-Tr:CCP45246,GOA:P9WJQ9,InterPro:IPR013482,InterPro:IPR025877,InterPro:IPR029044,NCBI_GP:CCP45246.1;Name=CCP45246.1;Note=Rv2453c%2C (MT2528%2C MTV008.09c)%2C len: 201 aa. Probable mobA%2C molybdopterin-guanine dinucleotide biosynthesis protein A%2C similar to others e.g. Q9F8G7 from Carboxydothermus hydrogenoformans (224 aa)%2C FASTA scores: opt: 249%2C E(): 3.9e-08%2C (30.6%25 identity in 173 aa overlap)%3B P95645|MOBA_RHOSH|mob|Y09560 from Rhodobacter sphaeroides (199 aa)%2C FASTA scores: opt: 240%2C E(): 1.2e-07%2C (33.9%25 identity in 186 aa overlap)%3B Q9X7K0|MOBA_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (191 aa)%2C FASTA scores: opt: 217%2C E(): 2.9e-06%2C (37.4%25 identity in 123 aa overlap)%3B etc. Belongs to the MobA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mobA;locus_tag=Rv2453c;product=Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA;protein_id=CCP45246.1;transl_table=11
AL123456.3	EMBL	gene	2753625	2754746	.	-	.	ID=gene-Rv2454c;Name=Rv2454c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2454c
AL123456.3	EMBL	CDS	2753625	2754746	.	-	0	ID=cds-CCP45247.1;Parent=gene-Rv2454c;Dbxref=EnsemblGenomes-Gn:Rv2454c,EnsemblGenomes-Tr:CCP45247,GOA:O53181,InterPro:IPR011766,InterPro:IPR029061,NCBI_GP:CCP45247.1;Name=CCP45247.1;Note=Rv2454c%2C (MTV008.10c)%2C len: 373 aa. Probable oxidoreductase%2C beta subunit%2C similar to Q9F2W7|SCD20.12c putative oxidoreductase from Streptomyces coelicolor (352 aa)%2C FASTA scores: opt: 1461%2C E(): 6.4e-85%2C (65.3%25 identity in 343 aa overlap) alias Q9RKS5|STAH10.34c putative oxidoreductase beta-subunit from Streptomyces coelicolor (350 aa)%2C FASTA scores: opt: 1429%2C E(): 6.7e-83%2C (64.0%25 identity in 342 aa overlap)%3B and similar in part to others e.g. Q9Z5X3 ferredoxin oxidoreductase B-subunit from Frankia sp. (346 aa)%2C FASTA scores: opt: 1143%2C E(): 7.5e-65%2C (51.2%25 identity in 336 aa overlap)%3B BAB21495|KORB ferredoxin oxidoreductase beta subunit from Hydrogenobacter thermophilus TK-6 (295 aa)%2C FASTA scores: opt: 682%2C E(): 8.3e-36%2C (48.25%25 identity in 201 aa overlap)%3B etc. Note that the upstream ORF (MTV008.11c|Rv2455c) is possibly an oxidoreductase alpha subunit.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2454c;product=Probable oxidoreductase (beta subunit);protein_id=CCP45247.1;transl_table=11
AL123456.3	EMBL	gene	2754743	2756704	.	-	.	ID=gene-Rv2455c;Name=Rv2455c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2455c
AL123456.3	EMBL	CDS	2754743	2756704	.	-	0	ID=cds-CCP45248.1;Parent=gene-Rv2455c;Dbxref=EnsemblGenomes-Gn:Rv2455c,EnsemblGenomes-Tr:CCP45248,GOA:O53182,InterPro:IPR002869,InterPro:IPR002880,InterPro:IPR009014,InterPro:IPR019752,InterPro:IPR022367,InterPro:IPR029061,NCBI_GP:CCP45248.1;Name=CCP45248.1;Note=Rv2455c%2C (MTV008.11c)%2C len: 653 aa. Probable oxidoreductase%2C alpha subunit%2C similar to others e.g. Q9F2W6|SCD20.13c putative oxidoreductase from Streptomyces coelicolor (645 aa)%2C FASTA scores: opt: 2017%2C E(): 1e-111%2C(66.45%25 identity in 617 aa overlap) alias Q9RKS4|STAH10.35c putative oxidoreductase alpha-subunit from Streptomyces coelicolor (630 aa)%2C FASTA scores: opt: 2008%2C E(): 3.4e-111%2C (66.45%25 identity in 614 aa overlap)%3B Q9YA13|APE2126 long hypothetical 2-oxoacid--ferredoxin oxidoreductase alpha chain from Aeropyrum pernix (644 aa) FASTA scores: opt: 687%2C E(): 4.6e-33%2C (33.35%25 identity in 441 aa overlap)%3B etc. Note that the downstream ORF (MTV008.10c|Rv2454c) is possibly an oxidoreductase beta subunit.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2455c;product=Probable oxidoreductase (alpha subunit);protein_id=CCP45248.1;transl_table=11
AL123456.3	EMBL	gene	2756936	2758192	.	-	.	ID=gene-Rv2456c;Name=Rv2456c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2456c
AL123456.3	EMBL	CDS	2756936	2758192	.	-	0	ID=cds-CCP45249.1;Parent=gene-Rv2456c;Dbxref=EnsemblGenomes-Gn:Rv2456c,EnsemblGenomes-Tr:CCP45249,GOA:P9WJX1,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP45249.1;Name=CCP45249.1;Note=Rv2456c%2C (MTV008.12c)%2C len: 418 aa. Probable conserved integral membrane transport protein%2C involved in a efflux system%2C weakly similar to many e.g. Q9RUR0|YD22_DEIRA|DR1322 putative sugar efflux transporter from Deinococcus radiodurans (389 aa)%2C FASTA scores: opt: 224%2C E(): 8.4e-06%2C (24.45%25 identity in 409 aa overlap)%3B Q9UYY0|PAB0913 multidrug resistance protein from Pyrococcus abyssi (410 aa)%2C FASTA scores: opt: 210%2C E(): 5.6e-05%2C(21.8%25 identity in 408 aa overlap)%3B etc. Contains PS00216 Sugar transport proteins signature 1.;gbkey=CDS;inference=protein motif:PROSITE:PS00216;locus_tag=Rv2456c;product=Probable conserved integral membrane transport protein;protein_id=CCP45249.1;transl_table=11
AL123456.3	EMBL	gene	2758208	2759488	.	-	.	ID=gene-Rv2457c;Name=clpX;gbkey=Gene;gene=clpX;gene_biotype=protein_coding;locus_tag=Rv2457c
AL123456.3	EMBL	CDS	2758208	2759488	.	-	0	ID=cds-CCP45250.1;Parent=gene-Rv2457c;Dbxref=EnsemblGenomes-Gn:Rv2457c,EnsemblGenomes-Tr:CCP45250,GOA:P9WPB9,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR004487,InterPro:IPR010603,InterPro:IPR019489,InterPro:IPR027417,NCBI_GP:CCP45250.1;Name=CCP45250.1;Note=Rv2457c%2C (MTV008.13c)%2C len: 426 aa. Probable clpX%2CATP-dependent clp protease ATP-binding subunit clpX%2Cequivalent to Q9CBY6|CLPX|ML1477 ATP-dependent CLP protease ATP-binding protein from Mycobacterium leprae (426 aa)%2CFASTA scores: opt: 2652%2C E(): 1.4e-142%2C (96.0%25 identity in 426 aa overlap). Also highly similar to others e.g. Q9F316|CLPX from Streptomyces coelicolor (428 aa) FASTA scores: opt: 2178%2C E(): 8.2e-116%2C (77.8%25 identity in 428 aa overlap)%3B P50866|CLPX_BACSU from Bacillus subtilis (420 aa)%2C FASTA scores: opt: 1788%2C E(): 8.5e-94%2C (63.6%25 identity in 426 aa overlap)%3B P33138|CLPX_ECOLI from Escherichia coli (423 aa)%2C FASTA scores: opt: 1694%2C E(): 1.7e-88%2C (62.4%25 identity in 415 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the CLPX chaperone family. Conserved in M. tuberculosis%2C M. leprae%2CM. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=clpX;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2457c;product=Probable ATP-dependent CLP protease ATP-binding subunit ClpX;protein_id=CCP45250.1;transl_table=11
AL123456.3	EMBL	gene	2759779	2760687	.	+	.	ID=gene-Rv2458;Name=mmuM;gbkey=Gene;gene=mmuM;gene_biotype=protein_coding;locus_tag=Rv2458
AL123456.3	EMBL	CDS	2759779	2760687	.	+	0	ID=cds-CCP45251.1;Parent=gene-Rv2458;Dbxref=EnsemblGenomes-Gn:Rv2458,EnsemblGenomes-Tr:CCP45251,GOA:O53185,InterPro:IPR003726,UniProtKB/TrEMBL:O53185,NCBI_GP:CCP45251.1;Name=CCP45251.1;Note=Rv2458%2C (MTV008.14)%2C len: 302 aa. Probable mmuM%2Chomocysteine S-methyltransferase%2C equivalent to Q9CBY5|ML1478 possible transferase from Mycobacterium leprae (293 aa)%2C FASTA scores: opt: 1507%2C E(): 2.7e-86%2C(78.85%25 identity in 293 aa overlap). Also similar to others e.g. Q47690|MMUM_ECOLI|B0261 homocysteine S-methyltransferase from Escherichia coli strain K12 (310 aa)%2C FASTA scores: opt: 863%2C E(): 2.4e-46%2C (47.65%25 identity in 298 aa overlap)%3B Q9FUM7 homocysteine S-methyltransferase-4 from Zea mays (Maize) (342 aa)%2C FASTA scores: opt: 324%2C E(): 6.8e-13%2C (44.45%25 identity in 306 aa overlap)%3B Q9LUI7|HMT3 cysteine methyltransferase from Arabidopsis thaliana (Mouse-ear cress) (347 aa)%2C FASTA scores: opt: 312%2C E(): 3.8e-12%2C (41.85%25 identity in 313 aa overlap)%3B etc. Identical to AAK46833|MT2533 homocysteine S-methyltransferase from Mycobacterium tuberculosis strain CDC1551 (302 aa).;gbkey=CDS;gene=mmuM;locus_tag=Rv2458;product=Probable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (cysteine methyltransferase);protein_id=CCP45251.1;transl_table=11
AL123456.3	EMBL	gene	2760854	2762380	.	+	.	ID=gene-Rv2459;Name=Rv2459;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2459
AL123456.3	EMBL	CDS	2760854	2762380	.	+	0	ID=cds-CCP45252.1;Parent=gene-Rv2459;Dbxref=EnsemblGenomes-Gn:Rv2459,EnsemblGenomes-Tr:CCP45252,GOA:P9WJW9,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP45252.1;Name=CCP45252.1;Note=Rv2459%2C (MTV008.15)%2C len: 508 aa. Probable conserved integral membrane transport protein%2C member of major facilitator superfamily (MFS) possibly involved in drug transport%2C highly similar to many efflux proteins e.g. Q9RL22|SC5G9.04c putative transmembrane efflux protein from Streptomyces coelicolor (489 aa)%2C FASTA scores: opt: 788%2CE(): 1.3e-38%2C (34.45%25 identity in 412 aa overlap)%3B Q9I428|PA1316 probable MFS transporter from Pseudomonas aeruginosa (513 aa)%2C FASTA scores: opt: 782%2C E(): 3.1e-38%2C(32.75%25 identity in 519 aa overlap)%3B P39886|TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa)%2C FASTA scores: opt: 752%2CE(): 1.8e-36%2C (31.7%25 identity in 511 aa overlap)%3B etc. Also highly similar to AAK46687|MT2395 drug transporter from Mycobacterium tuberculosis strain CDC1551 (537 aa)%2C FASTA scores: opt: 1396%2C E(): 5.6e-74%2C (44.45%25 identity in 504 aa overlap)%3B and P71879|Rv2333c|MTCY3G12.01 probable conserved integral membrane transport protein from Mycobacterium tuberculosis strain H37Rv (537 aa)%2C FASTA scores: opt: 1385%2C E(): 2.5e-73%2C (44.25%25 identity in 504 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2459;product=Probable conserved integral membrane transport protein;protein_id=CCP45252.1;transl_table=11
AL123456.3	EMBL	gene	2762531	2763175	.	-	.	ID=gene-Rv2460c;Name=clpP2;gbkey=Gene;gene=clpP2;gene_biotype=protein_coding;locus_tag=Rv2460c
AL123456.3	EMBL	CDS	2762531	2763175	.	-	0	ID=cds-CCP45253.1;Parent=gene-Rv2460c;Dbxref=EnsemblGenomes-Gn:Rv2460c,EnsemblGenomes-Tr:CCP45253,GOA:P9WPC3,InterPro:IPR001907,InterPro:IPR018215,InterPro:IPR023562,InterPro:IPR029045,PDB:4U0G,NCBI_GP:CCP45253.1;Name=CCP45253.1;Note=Rv2460c%2C (MT2535%2C MTV008.16c)%2C len: 214 aa. Probable clpP2%2C ATP-dependent clp protease proteolytic subunit 2%2Cequivalent to Q9CBY4|CLP2_MYCLE ATP-dependent CLP protease proteolytic subunit from Mycobacterium leprae (214 aa). Also highly similar to others e.g. Q9ZH58|CLPP2 from Streptomyces coelicolor (236 aa)%2C FASTA scores: opt: 918%2CE(): 2.1e-50%2C (66.35%25 identity in 214 aa overlap)%3B O67357|CLPP_AQUAE|AQ_1339 from Aquifex aeolicus (201 aa)%2CFASTA scores: opt: 680%2C E(): 1.4e-35%2C (52.0%25 identity in 194 aa overlap)%3B P43867|CLPP_HAEIN from Haemophilus influenzae (193 aa)%2C FASTA scores: opt: 662%2C E(): 1.8e-34%2C(53.35%25 identity in 193 aa overlap)%3B etc. Contains PS00381 Endopeptidase Clp serine active site. Also similar to upstream ORF Rv2461c|MTV008.17c|clpP1 (200 aa)%2C FASTA score: (48.3%25 identity in 172 aa overlap). Belongs to peptidase family S14%2C also known as ClpP family. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=clpP2;inference=protein motif:PROSITE:PS00381;locus_tag=Rv2460c;product=Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2);protein_id=CCP45253.1;transl_table=11
AL123456.3	EMBL	repeat_region	2762762	2763061	.	+	.	ID=id-AL123456.3:2762762..2763061;Note=300 bp direct repeat copy 1;gbkey=repeat_region
AL123456.3	EMBL	gene	2763172	2763774	.	-	.	ID=gene-Rv2461c;Name=clpP1;gbkey=Gene;gene=clpP1;gene_biotype=protein_coding;gene_synonym=clp;locus_tag=Rv2461c
AL123456.3	EMBL	CDS	2763172	2763774	.	-	0	ID=cds-CCP45254.1;Parent=gene-Rv2461c;Dbxref=EnsemblGenomes-Gn:Rv2461c,EnsemblGenomes-Tr:CCP45254,GOA:P9WPC5,InterPro:IPR001907,InterPro:IPR018215,InterPro:IPR023562,InterPro:IPR029045,PDB:2C8T,PDB:2CBY,PDB:2CE3,PDB:4U0G,PDB:4U0H,NCBI_GP:CCP45254.1;Name=CCP45254.1;Note=Rv2461c%2C (MT2536%2C MTV008.17c)%2C len: 200 aa. Probable clpP1%2C ATP-dependent clp protease proteolytic subunit 1%2Cequivalent to Q9CBY3|CLP1_MYCLE ATP-dependent CLP protease proteolytic subunit from Mycobacterium leprae (224 aa)%2CFASTA scores: opt: 1226%2C E(): 1.3e-71%2C (95.0%25 identity in 200 aa overlap). Also highly similar to others e.g. Q9F315|CLPP1 from Streptomyces coelicolor (219 aa)%2C FASTA scores: opt: 713%2C E(): 9.3e-39%2C (61.75%25 identity in 183 aa overlap)%3B P80244|CLPP_BACSU from Bacillus subtilis (197 aa)%2C FASTA scores: opt: 658%2C E(): 2.8e-35%2C (54%25 identity in 187 aa overlap)%3B Q9WZF9|CLPP_THEMA|TM0695 from Thermotoga maritima (203 aa)%2C FASTA scores: opt: 653%2C E(): 6.1e-35%2C(55.25%25 identity in 172 aa overlap)%3B etc. Also similar to downstream ORF Rv2460c|MTV008.16c|clpP2 (214 aa)%2C FASTA score: (48.3%25 identity in 172 aa overlap). Belongs to peptidase family S14%2C also known as CLPP family. Note that previously known as clp. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=clpP1;locus_tag=Rv2461c;product=Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP);protein_id=CCP45254.1;transl_table=11
AL123456.3	EMBL	repeat_region	2763397	2763696	.	+	.	ID=id-AL123456.3:2763397..2763696;Note=300 bp direct repeat copy 2;gbkey=repeat_region
AL123456.3	EMBL	gene	2763891	2765291	.	-	.	ID=gene-Rv2462c;Name=tig;gbkey=Gene;gene=tig;gene_biotype=protein_coding;locus_tag=Rv2462c
AL123456.3	EMBL	CDS	2763891	2765291	.	-	0	ID=cds-CCP45255.1;Parent=gene-Rv2462c;Dbxref=EnsemblGenomes-Gn:Rv2462c,EnsemblGenomes-Tr:CCP45255,GOA:P9WG55,InterPro:IPR001179,InterPro:IPR005215,InterPro:IPR008880,InterPro:IPR008881,InterPro:IPR027304,NCBI_GP:CCP45255.1;Name=CCP45255.1;Note=Rv2462c%2C (MTV008.18c)%2C len: 466 aa. Probable tig%2Ctrigger factor (TF)%2C a chaperone protein%2C equivalent to Q9CBY2|ML1481 possible molecular chaperone from Mycobacterium leprae (469 aa)%2C FASTA scores: opt: 2171%2CE(): 7.2e-113%2C (70.1%25 identity in 468 aa overlap). Also similar to oyher trigger factors from several organisms e.g. Q9F314|SCC80.05c from Streptomyces coelicolor (468 aa)%2C FASTA scores: opt: 1224%2C E(): 1.7e-60%2C (41.8%25 identity in 469 aa overlap)%3B Q9K8F3|TIG_BACHD from Bacillus halodurans (431 aa)%2C FASTA scores: opt: 675%2C E(): 3.6e-30%2C(28.5%25 identity in 421 aa overlap)%3B P22257|TIG_ECOLI from Escherichia coli (432 aa)%2C FASTA scores: opt: 493%2C E(): 4.2e-20%2C (23.35%25 identity in 433 aa overlap)%3B etc. Belongs to the FKBP-type PPIase family%2C TIG subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tig;locus_tag=Rv2462c;product=Probable trigger factor (TF) protein Tig;protein_id=CCP45255.1;transl_table=11
AL123456.3	EMBL	gene	2765331	2765404	.	-	.	ID=gene-proU;Name=proU;gbkey=Gene;gene=proU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2765331	2765404	.	-	.	ID=rna-proU;Parent=gene-proU;Note=codon recognized: CCA%3B proU%2C tRNA-Pro%3B anticodon tgg%2C length %3D 74;anticodon=(pos:complement(2765368..2765370));gbkey=tRNA;gene=proU;product=tRNA-Pro
AL123456.3	EMBL	exon	2765331	2765404	.	-	.	ID=exon-proU-1;Parent=rna-proU;Note=codon recognized: CCA%3B proU%2C tRNA-Pro%3B anticodon tgg%2C length %3D 74;anticodon=(pos:complement(2765368..2765370));gbkey=tRNA;gene=proU;product=tRNA-Pro
AL123456.3	EMBL	gene	2765541	2765611	.	+	.	ID=gene-glyV;Name=glyV;gbkey=Gene;gene=glyV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2765541	2765611	.	+	.	ID=rna-glyV;Parent=gene-glyV;Note=codon recognized: GGA%3B glyV%2C tRNA-Gly%3B anticodon tcc%2C length %3D 71;anticodon=(pos:2765573..2765575);gbkey=tRNA;gene=glyV;product=tRNA-Gly
AL123456.3	EMBL	exon	2765541	2765611	.	+	.	ID=exon-glyV-1;Parent=rna-glyV;Note=codon recognized: GGA%3B glyV%2C tRNA-Gly%3B anticodon tcc%2C length %3D 71;anticodon=(pos:2765573..2765575);gbkey=tRNA;gene=glyV;product=tRNA-Gly
AL123456.3	EMBL	gene	2765655	2766839	.	+	.	ID=gene-Rv2463;Name=lipP;gbkey=Gene;gene=lipP;gene_biotype=protein_coding;locus_tag=Rv2463
AL123456.3	EMBL	CDS	2765655	2766839	.	+	0	ID=cds-CCP45256.1;Parent=gene-Rv2463;Dbxref=EnsemblGenomes-Gn:Rv2463,EnsemblGenomes-Tr:CCP45256,GOA:O53190,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:O53190,NCBI_GP:CCP45256.1;Name=CCP45256.1;Note=Rv2463%2C (MTV008.19)%2C len: 394 aa. Probable lipP%2Cesterase%2C lipase similar to others eg O87861|ESTA esterase a from Streptomyces chrysomallus (389 aa)%2C FASTA scores: opt: 964%2C E(): 1.9e-53%2C (44.35%25 identity in 399 aa overlap)%3B Q9I4S7|PA1047 probable esterase from Pseudomonas aeruginosa (392 aa)%2C FASTA scores: opt: 863%2C E(): 4.6e-47%2C(40.05%25 identity in 377 aa overlap)%3B Q53403|ESTC esterase III from Pseudomonas fluorescens (382 aa)%2C FASTA scores: opt: 753%2C E(): 3.9e-40%2C (36.3%25 identity in 380 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipP;locus_tag=Rv2463;product=Probable esterase/lipase LipP;protein_id=CCP45256.1;transl_table=11
AL123456.3	EMBL	gene	2766859	2767665	.	-	.	ID=gene-Rv2464c;Name=Rv2464c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2464c
AL123456.3	EMBL	CDS	2766859	2767665	.	-	0	ID=cds-CCP45257.1;Parent=gene-Rv2464c;Dbxref=EnsemblGenomes-Gn:Rv2464c,EnsemblGenomes-Tr:CCP45257,GOA:P9WNB9,InterPro:IPR000214,InterPro:IPR010663,InterPro:IPR010979,InterPro:IPR012319,InterPro:IPR015886,InterPro:IPR015887,NCBI_GP:CCP45257.1;Name=CCP45257.1;Note=Rv2464c%2C (MT2539%2C MTV008.20c)%2C len: 268 aa. Possible DNA glycosylase%2C showing some similarity to several other DNA glycosylases e.g. Q9F308|SCC80.11c putative DNA repair hydrolase (fragment) from Streptomyces coelicolor (306 aa)%2CFASTA scores: opt: 894%2C E(): 6.1e-51%2C (51.05%25 identity in 282 aa overlap)%3B O50606|MUTM|FPG_THETH formamidopyrimidine-DNA glycosylase from Thermus aquaticus (267 aa)%2C FASTA scores: opt: 342%2C E(): 4.6e-15%2C (32.4%25 identity in 250 aa overlap)%3B Q9RCW5|SCM10.34c putative formamidopyrimidine-DNA glycosylase from Streptomyces coelicolor (287 aa)%2C FASTA scores: opt: 321%2C E(): 1.1e-13%2C(29.35%25 identity in 259 aa overlap)%3B etc. Identical to AAK46839|MT2539 formamidopyrimidine-DNA glycosylase from Mycobacterium tuberculosis strain CDC1551. Also similar to other Mycobacterium tuberculosis DNA glycosylases e.g. MTCY71.37 (32.9%25 identity in 277 aa overlap). Belongs to the FPG family.;gbkey=CDS;locus_tag=Rv2464c;product=Possible DNA glycosylase;protein_id=CCP45257.1;transl_table=11
AL123456.3	EMBL	gene	2767671	2768159	.	-	.	ID=gene-Rv2465c;Name=rpiB;gbkey=Gene;gene=rpiB;gene_biotype=protein_coding;locus_tag=Rv2465c
AL123456.3	EMBL	CDS	2767671	2768159	.	-	0	ID=cds-CCP45258.1;Parent=gene-Rv2465c;Dbxref=EnsemblGenomes-Gn:Rv2465c,EnsemblGenomes-Tr:CCP45258,GOA:P9WKD7,InterPro:IPR003500,InterPro:IPR011860,PDB:1USL,PDB:2BES,PDB:2BET,PDB:2VVO,PDB:2VVP,PDB:2VVQ,NCBI_GP:CCP45258.1;Name=CCP45258.1;Note=Rv2465c%2C (MTV008.21c)%2C len: 162 aa. RpiB%2CRibose-5-phosphate isomerase%2C proven biochemically (see Roos et al.%2C 2004) equivalent to AAK46840|MT2540 putative carbohydrate-phosphate isomerase from Mycobacterium tuberculosis strain CDC1551 (159 aa). Equivalent to Q9CBY1|ML1484 possible phosphopentose isomerase from Mycobacterium leprae (162 aa)%2C FASTA scores: opt: 992%2C E(): 7.1e-59%2C (89.5%25 identity in 162 aa overlap). Also highly similar or similar to several diverse isomerases e.g. Q9L206|SC8E4.02c putative isomerase from Streptomyces coelicolor (159 aa)%2C FASTA scores: opt: 661%2C E(): 6.1e-37%2C(61.45%25 identity in 153 aa overlap)%3B P47636|Y396_MYCGE|MG396 hypothetical LACA/RPIB family protein from Mycoplasma genitalium (152 aa)%2C FASTA scores: opt: 357%2C E(): 8.2e-17%2C (42%25 identity in 150 aa overlap)%3B P53527|Y396_MYCPN|MPN595|MP247 hypothetical LACA/RPIB family protein from Mycoplasma pneumoniae (152 aa)%2C FASTA scores: opt: 340%2C E(): 1.1e-15%2C (38.6%25 identity in 145 aa overlap)%3B P26592|LACB_STAAU galactose-6-phosphate isomerase from Staphylococcus aureus (171 aa)%2C FASTA scores: opt: 296%2C E(): 1e-12%2C (35.4%25 identity in 158 aa overlap) and P37351|RPIB_ECOLI ribose 5-phosphate isomerase b from Escherichia coli (149 aa)%2C FASTA scores: opt: 262%2C E(): 1.6e-10%2C (32.2%25 identity in 146 aa overlap)%3B etc. Could belong to the LACA/RPIB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpiB;locus_tag=Rv2465c;product=Ribose-5-phosphate isomerase;protein_id=CCP45258.1;transl_table=11
AL123456.3	EMBL	gene	2768261	2768884	.	-	.	ID=gene-Rv2466c;Name=Rv2466c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2466c
AL123456.3	EMBL	CDS	2768261	2768884	.	-	0	ID=cds-CCP45259.1;Parent=gene-Rv2466c;Dbxref=EnsemblGenomes-Gn:Rv2466c,EnsemblGenomes-Tr:CCP45259,GOA:O53193,InterPro:IPR001853,InterPro:IPR012336,UniProtKB/TrEMBL:O53193,NCBI_GP:CCP45259.1;Name=CCP45259.1;Note=Rv2466c%2C (MTV008.22c)%2C len: 207 aa. Conserved protein (see citation below)%2C equivalent to Q9CBY0|ML1485 hypothetical protein from Mycobacterium leprae (207 aa)%2CFASTA scores: opt: 1154%2C E(): 1.1e-67%2C (80.6%25 identity in 206 aa overlap). Also highly similar to Q9L201|SC8E4A.04c hypothetical protein from Streptomyces coelicolor (216 aa)%2CFASTA scores: opt: 789%2C E(): 4.6e-44%2C (57.9%25 identity in 213 aa overlap). Also similar to AAK46628|MT2344 hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (230 aa)%2C FASTA scores: opt: 324%2C E(): 6.1e-14%2C(30.4%25 identity in 194 aa overlap). Contains PS00195 Glutaredoxin active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00195;locus_tag=Rv2466c;product=Conserved protein;protein_id=CCP45259.1;transl_table=11
AL123456.3	EMBL	gene	2768986	2771571	.	+	.	ID=gene-Rv2467;Name=pepN;gbkey=Gene;gene=pepN;gene_biotype=protein_coding;gene_synonym=pepD;locus_tag=Rv2467
AL123456.3	EMBL	CDS	2768986	2771571	.	+	0	ID=cds-CCP45260.1;Parent=gene-Rv2467;Dbxref=EnsemblGenomes-Gn:Rv2467,EnsemblGenomes-Tr:CCP45260,GOA:L7N655,InterPro:IPR001930,InterPro:IPR012778,InterPro:IPR014782,InterPro:IPR024571,UniProtKB/TrEMBL:L7N655,NCBI_GP:CCP45260.1;Name=CCP45260.1;Note=Rv2467%2C (MTV008.23)%2C len: 861 aa. Probable pepN%2Caminopeptidase N%2C equivalent to Q9CBX9|ML1486 probable aminopeptidase from Mycobacterium leprae (862 aa)%2C FASTA scores: opt: 4751%2CE(): 0%2C (83.3%25 identity in 862 aa overlap). Also highly similar to others e.g. Q11010|AMPN_STRLI|PEPN from Streptomyces lividans (857 aa)%2CFASTA scores: opt: 2839%2C E(): 1.8e-170%2C (53.25%25 identity in 864 aa overlap)%3B Q9L1Z2|PEPN from Streptomyces coelicolor (857 aa)%2C FASTA scores: opt: 2834%2C E(): 3.8e-170%2C (53.1%25 identity in 864 aa overlap)%3B P37896|AMPN_LACDL|PEPN from Lactobacillus delbrueckii (subsp. lactis) (842 aa)%2C FASTA scores: opt: 719%2C E(): 2.4e-37%2C (31.65%25 identity in 439 aa overlap)%3B etc. Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Belongs to peptidase family M1 (zinc metalloprotease)%2C also known as the PEPN subfamily. Note that previously known as pepD. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepN;inference=protein motif:PROSITE:PS00142;locus_tag=Rv2467;product=Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase);protein_id=CCP45260.1;transl_table=11
AL123456.3	EMBL	gene	2771644	2772147	.	-	.	ID=gene-Rv2468c;Name=Rv2468c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2468c
AL123456.3	EMBL	CDS	2771644	2772147	.	-	0	ID=cds-CCP45261.1;Parent=gene-Rv2468c;Dbxref=EnsemblGenomes-Gn:Rv2468c,EnsemblGenomes-Tr:CCP45261,GOA:P9WLA7,NCBI_GP:CCP45261.1;Name=CCP45261.1;Note=Rv2468c%2C (MTV008.24c)%2C len: 167 aa. Conserved protein%2C highly similar to Mycobacterium leprae hypothetical proteins Q9CC58|ML1255 (163 aa)%2C FASTA scores: opt: 859%2C E(): 1.6e-49%2C (81.2%25 identity in 165 aa overlap) and Q9X7B5|MLCB1610.16 (169 aa)%2C FASTA scores: opt: 859%2CE(): 1.6e-49%2C (81.2%25 identity in 165 aa overlap). Also weak similarity with Q9X8D7|SCE39.14c putative GntR-family regulator from Streptomyces coelicolor (243 aa)%2C FASTA scores: opt: 116%2C E(): 1.3%2C (30.1%25 identity in 156 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2468c;product=Conserved protein;protein_id=CCP45261.1;transl_table=11
AL123456.3	EMBL	gene	2772098	2772331	.	-	.	ID=gene-Rv2468A;Name=Rv2468A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2468A
AL123456.3	EMBL	CDS	2772098	2772331	.	-	0	ID=cds-CCP45262.1;Parent=gene-Rv2468A;Dbxref=EnsemblGenomes-Gn:Rv2468A,EnsemblGenomes-Tr:CCP45262,UniProtKB/TrEMBL:I6YDH3,NCBI_GP:CCP45262.1;Name=CCP45262.1;Note=Rv2468A%2C len: 77 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2468A;product=Conserved protein;protein_id=CCP45262.1;transl_table=11
AL123456.3	EMBL	gene	2772367	2773035	.	-	.	ID=gene-Rv2469c;Name=Rv2469c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2469c
AL123456.3	EMBL	CDS	2772367	2773035	.	-	0	ID=cds-CCP45263.1;Parent=gene-Rv2469c;Dbxref=EnsemblGenomes-Gn:Rv2469c,EnsemblGenomes-Tr:CCP45263,GOA:O53196,InterPro:IPR002711,InterPro:IPR003615,UniProtKB/TrEMBL:O53196,NCBI_GP:CCP45263.1;Name=CCP45263.1;Note=Rv2469c%2C (MTV008.25c)%2C len: 222 aa. Conserved hypothetical protein%2C highly similar to other hypothetical proteins e.g. Q9X7B4|MLCB1610.15|ML1254 from Mycobacterium leprae (215 aa)%2C FASTA scores: opt: 1183%2C E(): 3.3e-70%2C(77.9%25 identity in 222 aa overlap)%3B Q9L1Y0|SC8E4A.25c from Streptomyces coelicolor (178 aa)%2C FASTA scores: opt: 589%2CE(): 1.7e-31%2C (53.4%25 identity in 161 aa overlap) (N-terminal region is shorter 50 aa approximately)%3B Q9RRS6|DR2409 conserved hypothetical protein from Deinococcus radiodurans (186 aa)%2C FASTA scores: opt: 440%2CE(): 9.6e-22%2C (42.25%25 identity in 168 aa overlap) (N-terminal region is shorter 30 aa approximately)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2469c;product=Conserved hypothetical protein;protein_id=CCP45263.1;transl_table=11
AL123456.3	EMBL	gene	2773178	2773564	.	+	.	ID=gene-Rv2470;Name=glbO;gbkey=Gene;gene=glbO;gene_biotype=protein_coding;locus_tag=Rv2470
AL123456.3	EMBL	CDS	2773178	2773564	.	+	0	ID=cds-CCP45264.1;Parent=gene-Rv2470;Dbxref=EnsemblGenomes-Gn:Rv2470,EnsemblGenomes-Tr:CCP45264,GOA:P9WN23,InterPro:IPR001486,InterPro:IPR009050,InterPro:IPR012292,InterPro:IPR019795,PDB:1NGK,PDB:2QRW,NCBI_GP:CCP45264.1;Name=CCP45264.1;Note=Rv2470%2C (MTV008.26)%2C len: 128 aa. glbO%2C globin-like protein%2C highly similar to Q9CC59|GLBO|ML1253 hemoglobin-like (oxygen carrier) from Mycobacterium leprae (128 aa)%2C FASTA scores: opt: 767%2C E(): 4e-47%2C (88.1%25 identity in 126 aa overlap)%3B Q9X7B3|MLCB1610.14c putative globin from Mycobacterium leprae (131 aa)%3B Q9L250|SC6D10.14 putative globin from Streptomyces coelicolor (137 aa)%2CFASTA scores: opt: 466%2C E(): 5.7e-26%2C (53.6%25 identity in 125 aa overlap). Also similar to O31607 YJBI protein from Bacillus subtilis (132 aa)%2C FASTA scores: opt: 294%2C E(): 6.6e-14%3B (39.85%25 identity in 128 aa overlap). Could belong to protozoan/cyanobacterial globin family protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glbO;locus_tag=Rv2470;product=Globin (oxygen-binding protein) GlbO;protein_id=CCP45264.1;transl_table=11
AL123456.3	EMBL	gene	2773564	2775204	.	+	.	ID=gene-Rv2471;Name=aglA;gbkey=Gene;gene=aglA;gene_biotype=protein_coding;locus_tag=Rv2471
AL123456.3	EMBL	CDS	2773564	2775204	.	+	0	ID=cds-CCP45265.1;Parent=gene-Rv2471;Dbxref=EnsemblGenomes-Gn:Rv2471,EnsemblGenomes-Tr:CCP45265,GOA:O53198,InterPro:IPR006047,InterPro:IPR006589,InterPro:IPR013781,InterPro:IPR015902,InterPro:IPR017853,UniProtKB/TrEMBL:O53198,NCBI_GP:CCP45265.1;Name=CCP45265.1;Note=Rv2471%2C (MTV008.27)%2C len: 546 aa. Probable aglA%2Cmaltase (alpha-glucosidase)%2C highly similar or similar to several e.g. Q60027|AGLA from Thermomonospora curvata (544 aa)%2C FASTA scores: opt: 2071%2C E(): 4e-116%2C (57.7%25 identity in 525 aa overlap)%3B Q9KZE3|AGLAE from Streptomyces coelicolor (534 aa)%2C FASTA scores: opt: 1475%2C E(): 1.5e-80%2C(50.1%25 identity in 537 aa overlap)%3B O86874|AGLA from Streptomyces lividans (534 aa)%2C FASTA scores: opt: 1473%2CE(): 2e-80%2C (50.1%25 identity in 537 aa overlap)%3B etc. Seems to belong to family 13 of glycosyl hydrolases%2C also known as the alpha-amylase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aglA;locus_tag=Rv2471;product=Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidase) (acid maltase);protein_id=CCP45265.1;transl_table=11
AL123456.3	EMBL	gene	2775272	2775565	.	+	.	ID=gene-Rv2472;Name=Rv2472;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2472
AL123456.3	EMBL	CDS	2775272	2775565	.	+	0	ID=cds-CCP45266.1;Parent=gene-Rv2472;Dbxref=EnsemblGenomes-Gn:Rv2472,EnsemblGenomes-Tr:CCP45266,UniProtKB/TrEMBL:O53199,NCBI_GP:CCP45266.1;Name=CCP45266.1;Note=Rv2472%2C (MTV008.28)%2C len: 97 aa. Conserved hypothetical protein%2C showing some similarity to O53451|Rv1103c|MTV017.56c from Mycobacterium tuberculosis strain H37Rv (106 aa)%2C FASTA scores: opt: 135%2C E(): 0.026%2C(45.85%25 identity in 72 aa overlap)%3B and AAK45393|MT1135 hypothetical 11.4 KDA protein from Mycobacterium tuberculosis strain CDC1551 (78 aa) FASTA scores: opt: 139%2CE(): 0.011%2C (45.35%25 identity in 75 aa overlap).;gbkey=CDS;locus_tag=Rv2472;product=Conserved hypothetical protein;protein_id=CCP45266.1;transl_table=11
AL123456.3	EMBL	gene	2775568	2776284	.	+	.	ID=gene-Rv2473;Name=Rv2473;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2473
AL123456.3	EMBL	CDS	2775568	2776284	.	+	0	ID=cds-CCP45267.1;Parent=gene-Rv2473;Dbxref=EnsemblGenomes-Gn:Rv2473,EnsemblGenomes-Tr:CCP45267,UniProtKB/TrEMBL:O53200,NCBI_GP:CCP45267.1;Name=CCP45267.1;Note=Rv2473%2C (MTV008.29)%2C len: 238 aa. Possible pro-%2Cala-rich membrane protein%2C with possible transmembrane domain around aa 81-104.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2473;product=Possible alanine and proline rich membrane protein;protein_id=CCP45267.1;transl_table=11
AL123456.3	EMBL	gene	2776316	2776969	.	-	.	ID=gene-Rv2474c;Name=Rv2474c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2474c
AL123456.3	EMBL	CDS	2776316	2776969	.	-	0	ID=cds-CCP45268.1;Parent=gene-Rv2474c;Dbxref=EnsemblGenomes-Gn:Rv2474c,EnsemblGenomes-Tr:CCP45268,InterPro:IPR016601,UniProtKB/TrEMBL:I6X4D6,NCBI_GP:CCP45268.1;Name=CCP45268.1;Note=Rv2474c%2C (MTV008.30c)%2C len: 217 aa. Hypothetical protein. Shows weak similarity with Q9L246|SC6D10.18c hypothetical 24.9 KDA protein from Streptomyces coelicolor (238 aa)%2C FASTA scores: opt: 111%2C E(): 5.6%2C (30%25 identity in 233 aa overlap)%2C blastp scores: Score%3D 135%2C E%3D 3.5e-07%2CP%3D 3.5e-07%2C Identities%3D 55/182 (30%25).;gbkey=CDS;locus_tag=Rv2474c;product=Conserved hypothetical protein;protein_id=CCP45268.1;transl_table=11
AL123456.3	EMBL	gene	2776975	2777391	.	-	.	ID=gene-Rv2475c;Name=Rv2475c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2475c
AL123456.3	EMBL	CDS	2776975	2777391	.	-	0	ID=cds-CCP45269.1;Parent=gene-Rv2475c;Dbxref=EnsemblGenomes-Gn:Rv2475c,EnsemblGenomes-Tr:CCP45269,GOA:I6Y9E8,InterPro:IPR029069,UniProtKB/TrEMBL:I6Y9E8,NCBI_GP:CCP45269.1;Name=CCP45269.1;Note=Rv2475c%2C (MTV008.31c)%2C len: 138 aa. Conserved protein%2C showing similarity with Q9L245|SC6D10.19c hypothetical 16.2 KDA protein from Streptomyces coelicolor (136 aa)%2C FASTA scores: opt: 236%2C E(): 1.9e-09%2C (34.1%25 identity in 126 aa overlap). Also some similarity with AAK44393|Z97050|MTCI28_3 conserved hypothetical protein from Mycobacterium tuberculosis cosmid I (151 aa)%2C FASTA scores: opt: 147%2C E(): 0.00025%2C (29.2%25 identity in 120 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2475c;product=Conserved protein;protein_id=CCP45269.1;transl_table=11
AL123456.3	EMBL	gene	2777388	2782262	.	-	.	ID=gene-Rv2476c;Name=gdh;gbkey=Gene;gene=gdh;gene_biotype=protein_coding;locus_tag=Rv2476c
AL123456.3	EMBL	CDS	2777388	2782262	.	-	0	ID=cds-CCP45270.1;Parent=gene-Rv2476c;Dbxref=EnsemblGenomes-Gn:Rv2476c,EnsemblGenomes-Tr:CCP45270,GOA:O53203,InterPro:IPR007780,InterPro:IPR016040,InterPro:IPR028971,NCBI_GP:CCP45270.1;Name=CCP45270.1;Note=Rv2476c%2C (MTV008.32c)%2C len: 1624 aa. Probable gdh%2Cglutamate dehydrogenase. Highly similar to Q9X7B2|MLCB1610.10|ML1249 hypothetical 177.9 KDA protein from Mycobacterium leprae (1622 aa)%2C FASTA scores: opt: 8630%2CE(): 0%2C (81.45%25 identity in 1634 aa overlap). But highly similar to Q9F0J1|GDH NAD-glutamate dehydrogenase from Streptomyces clavuligerus (1651 aa)%2C FASTA scores: opt: 3833%2C E(): 0%2C (45.8%25 identity in 1600 aa overlap)%3B (see Minambres et al.%2C 2000). Also similar with others e.g. AAG53963|PA3068|GDHB hypothetical (NAD(+)-dependent glutamate dehydrogenase from Pseudomonas aeruginosa (1620 aa)%2C FASTA scores: opt: 2214%2C E(): 1e-124%2C (40.1%25 identity in 1561 aa overlap) (see Lu %26 Abdelal 2001)%3B and Q9Y8G5|GDHB NAD-specific glutamate dehydrogenase from Agaricus bisporus (1029 aa)%2C FASTA scores: opt: 194%2C E(): 0.00099%2C (22.7%25 identity in 647 aa overlap) (see Kersten et al.%2C 1999)%3B etc. Contains possible Helix-turn-helix motif at aa 1568 to 1589 (score 1098%2C +2.93 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gdh;locus_tag=Rv2476c;product=Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase);protein_id=CCP45270.1;transl_table=11
AL123456.3	EMBL	gene	2782366	2784042	.	-	.	ID=gene-Rv2477c;Name=Rv2477c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2477c
AL123456.3	EMBL	CDS	2782366	2784042	.	-	0	ID=cds-CCP45271.1;Parent=gene-Rv2477c;Dbxref=EnsemblGenomes-Gn:Rv2477c,EnsemblGenomes-Tr:CCP45271,GOA:P9WQK3,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR022374,InterPro:IPR027417,NCBI_GP:CCP45271.1;Name=CCP45271.1;Note=Rv2477c%2C (MTV008.33c)%2C len: 558 aa. Probable ATP binding protein ABC-transporter (see citation below)%2Cprobably involved in macrolide transport%2C equivalent to Q9X7B1|MLCB1610.09|ML1248 putative ABC transporter ATP-binding protein from Mycobacterium leprae (556 aa) FASTA scores: opt: 3448%2C E(): 3.8e-176%2C (92.3%25 identity in 557 aa overlap). Also highly similar to many ATP binding proteins e.g. Q9L244|SC6D10.20c putative ABC transporter ATP-binding protein from Streptomyces coelicolor (547 aa)%2CFASTA scores: opt: 2937%2C E(): 5.6e-149%2C (79.5%25 identity in 551 aa overlap)%3B AAK24119|CC2148 ABC transporter ATP-binding protein from Caulobacter crescentus (555 aa)%2CFASTA scores: opt: 2175%2C E(): 1.9e-108%2C (59.4%25 identity in 557 aa overlap)%3B Q9HVJ1 probable ATP-binding component of ABC transporter from Pseudomonas aeruginosa (554 aa)%2C FASTA scores: opt: 2054%2C E(): 5.1e-102%2C (56.9%25 identity in 559 aa overlap)%3B etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop)%2C 2 x PS00211 ABC transporters family signature%2C and probable coiled-coil from aa 273 to 311. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00211;locus_tag=Rv2477c;product=Probable macrolide-transport ATP-binding protein ABC transporter;protein_id=CCP45271.1;transl_table=11
AL123456.3	EMBL	gene	2784123	2784608	.	-	.	ID=gene-Rv2478c;Name=Rv2478c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2478c
AL123456.3	EMBL	CDS	2784123	2784608	.	-	0	ID=cds-CCP45272.1;Parent=gene-Rv2478c;Dbxref=EnsemblGenomes-Gn:Rv2478c,EnsemblGenomes-Tr:CCP45272,GOA:O53205,InterPro:IPR000424,InterPro:IPR011344,InterPro:IPR012340,UniProtKB/TrEMBL:O53205,NCBI_GP:CCP45272.1;Name=CCP45272.1;Note=Rv2478c%2C (MTV008.34c)%2C len: 161 aa. Conserved hypothetical protein%2C with weak similarity with many single-strand binding proteins e.g. Q9X8U3|SCH24.29 putative single-strand binding protein from Streptomyces coelicolor (199 aa)%2C FASTA scores: opt: 246%2C E(): 4.5e-08%2C(31.5%25 identity in 162 aa overlap)%3B P46390|SSB_MYCLE|ML2684|MLCB1913.20c single-strand binding protein (SSB) (helix-destabilizing protein) from Mycobacterium leprae (168 aa)%2C FASTA scores: opt: 239%2C E(): 1e-07%2C (30.8%25 identity in 146 aa overlap)%3B P18310|SSBF_ECOLI single-strand binding protein from Escherichia coli (178 aa)%2C FASTA scores: opt: 116%2C E(): 2.9%2C (25.7%25 identity in 140 aa overlap)%3B etc. Also similarity with Rv0054|P71711|MTCY21D4.17|SSB_MYCTU probable single-strand binding protein from M. tuberculosis (164 aa)%2C FASTA scores: opt: 234%2C E(): 2e-07%2C (31.75%25 identity in 148 aa overlap). N-terminus shorter 8 aa from AAK46855|MT2553 single-strand DNA binding protein from Mycobacterium tuberculosis strain CDC1551.;gbkey=CDS;locus_tag=Rv2478c;product=Conserved hypothetical protein;protein_id=CCP45272.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2784614	2785970	.	-	.	ID=id-AL123456.3:2784614..2785970;Note=IS6110-9%2C len: 1357 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-9
AL123456.3	EMBL	repeat_region	2784614	2784642	.	+	.	ID=id-AL123456.3:2784614..2784642;Note=29 bp Inverted repeat at the left end of IS6110%2CGTGAACCGCCCCGGTGAGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	2784657	2785643	.	-	.	ID=gene-Rv2479c;Name=Rv2479c;end_range=2785643,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2479c;partial=true
AL123456.3	EMBL	CDS	2784657	2785643	.	-	0	ID=cds-CCP45273.1;Parent=gene-Rv2479c;Dbxref=EnsemblGenomes-Gn:Rv2479c,EnsemblGenomes-Tr:CCP45273,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP45273.1;Name=CCP45273.1;Note=Rv2479c%2C (MTV008.35c)%2C len: 328 aa. Probable transposase for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2480c and Rv2479c%2C the sequence UUUUAAAG (directly upstream of Rv2479c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (- 18 aa).;end_range=2785643,.;gbkey=CDS;locus_tag=Rv2479c;partial=true;product=Probable transposase;protein_id=CCP45273.1;transl_table=11
AL123456.3	EMBL	gene	2785592	2785918	.	-	.	ID=gene-Rv2480c;Name=Rv2480c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2480c
AL123456.3	EMBL	CDS	2785592	2785918	.	-	0	ID=cds-CCP45274.1;Parent=gene-Rv2480c;Dbxref=EnsemblGenomes-Gn:Rv2480c,EnsemblGenomes-Tr:CCP45274,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP45274.1;Name=CCP45274.1;Note=Rv2480c%2C (MTV008.36c)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2480c and Rv2479c%2C the sequence UUUUAAAG (directly upstream of Rv2479c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv2480c;product=Possible transposase for insertion sequence element IS6110 (fragment);protein_id=CCP45274.1;transl_table=11
AL123456.3	EMBL	repeat_region	2785942	2785970	.	-	.	ID=id-AL123456.3:2785942..2785970;Note=29 bp Inverted repeat at the right end of IS6110%2CGTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	2786575	2786898	.	-	.	ID=gene-Rv2481c;Name=Rv2481c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2481c
AL123456.3	EMBL	CDS	2786575	2786898	.	-	0	ID=cds-CCP45275.1;Parent=gene-Rv2481c;Dbxref=EnsemblGenomes-Gn:Rv2481c,EnsemblGenomes-Tr:CCP45275,UniProtKB/TrEMBL:O53206,NCBI_GP:CCP45275.1;Name=CCP45275.1;Note=Rv2481c%2C (MTV008.37c)%2C len: 107 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2481c;product=Hypothetical protein;protein_id=CCP45275.1;transl_table=11
AL123456.3	EMBL	gene	2786914	2789283	.	-	.	ID=gene-Rv2482c;Name=plsB2;gbkey=Gene;gene=plsB2;gene_biotype=protein_coding;locus_tag=Rv2482c
AL123456.3	EMBL	CDS	2786914	2789283	.	-	0	ID=cds-CCP45276.1;Parent=gene-Rv2482c;Dbxref=EnsemblGenomes-Gn:Rv2482c,EnsemblGenomes-Tr:CCP45276,GOA:P9WI61,InterPro:IPR002123,InterPro:IPR022284,InterPro:IPR028354,NCBI_GP:CCP45276.1;Name=CCP45276.1;Note=Rv2482c%2C (MT2555%2C MTV008.38c)%2C len: 789 aa. Probable plsB2%2C glycerol-3-phosphate acyltransferase%2C highly similar to Q9X7B0|PLSB_MYCLE probable glycerol-3-phosphate acyltransferase from Mycobacterium leprae (775 aa)%2C FASTA scores: opt: 4210%2C E(): 0%2C (80.7%25 identity in 783 aa overlap). Also similar to others e.g. P00482|PLSB_ECOLI from Escherichia coli (806 aa)%2C FASTA scores: opt: 521%2CE(): 3e-24%2C (24.35 identity in 612 aa overlap)%3B Q9CLN7|PLSB_PASMU from Pasteurella multocida (809 aa)%2CFASTA scores: opt: 529%2C E(): 9.7e-25%2C (27.05%25 identity in 540 aa overlap)%3B Q9KVP8|PLSB_VIBCH from Vibrio cholerae (811 aa)%2C FASTA scores: opt: 510%2C E(): 1.4e-23%2C (26.0%25 identity in 639 aa overlap)%3B etc. Also highly similar to Q10775|PLSB1|Rv1551|MTCY48.14c from M. tuberculosis (621 aa)%2C FASTA scores: opt: 1013%2C E(): 1.5e-54%2C (34.65%25 identity in 586 aa overlap). Belongs to the GPAT/DAPAT family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=plsB2;locus_tag=Rv2482c;product=Probable glycerol-3-phosphate acyltransferase PlsB2 (GPAT);protein_id=CCP45276.1;transl_table=11
AL123456.3	EMBL	gene	2789280	2791022	.	-	.	ID=gene-Rv2483c;Name=plsC;gbkey=Gene;gene=plsC;gene_biotype=protein_coding;locus_tag=Rv2483c
AL123456.3	EMBL	CDS	2789280	2791022	.	-	0	ID=cds-CCP45277.1;Parent=gene-Rv2483c;Dbxref=EnsemblGenomes-Gn:Rv2483c,EnsemblGenomes-Tr:CCP45277,GOA:I6YDI9,InterPro:IPR002123,InterPro:IPR006383,InterPro:IPR006385,InterPro:IPR023214,UniProtKB/TrEMBL:I6YDI9,NCBI_GP:CCP45277.1;Name=CCP45277.1;Note=Rv2483c%2C (MTV008.39c)%2C len: 580 aa. Possible plsC%2C a transmembrane phospholipid biosynthesis bifunctional enzyme%2C including L-3-phosphoserine phosphatase and 1-acyl-Sn-glycerol-3-phosphate acyltransferase %2C equivalent to Q9X7A9|PLSC|ML1245 putative acyltransferase from Mycobacterium leprae (579 aa)%2C FASTA scores: opt: 2835%2CE(): 9.2e-153%2C (77.15%25 identity in 573 aa overlap). C-terminal end is similar to many 1-acyl-SN-glycerol-3-phosphate acyltransferases (lysophosphatidic acidacyltransferases) e.g. Q9SDQ2 from Limnanthes floccosa (281 aa)%2C FASTA scores: opt: 378%2C E(): 3.1e-14%2C (30.0%25 identity in 230 aa overlap) and Q42868|PLSC_LIMAL from Limnanthes alba (White meadowfoam) (281 aa)%2C FASTA scores: opt: 374%2C E(): 5.2e-14%2C (30.55%25 identity in 221 aa overlap)%3B and the N-terminal end is similar to many SerB family proteins e.g. AAK44749|MT0526 from Mycobacterium tuberculosis strain CDC1551 (308 aa)%2CFASTA scores: opt: 356%2C E(): 5.8e-13%2C (32.5%25 identity in 298 aa overlap) and Q49823|ML2424 from Mycobacterium leprae (300 aa)%2C FASTA scores: opt: 346%2C E(): 2.1e-12%2C (32.0%25 identity in 278 aa overlap). So belongs to the 1-acyl-SN-glycerol-3-phosphate acyltransferase family and may belong to the SerB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=plsC;locus_tag=Rv2483c;product=Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoserine phosphohydrolase) (PSP) (pspase) + 1-acyl-SN-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid acyltransferase) (LPAAT);protein_id=CCP45277.1;transl_table=11
AL123456.3	EMBL	gene	2791019	2792494	.	-	.	ID=gene-Rv2484c;Name=Rv2484c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2484c
AL123456.3	EMBL	CDS	2791019	2792494	.	-	0	ID=cds-CCP45278.1;Parent=gene-Rv2484c;Dbxref=EnsemblGenomes-Gn:Rv2484c,EnsemblGenomes-Tr:CCP45278,GOA:P9WKB3,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP45278.1;Name=CCP45278.1;Note=Rv2484c%2C (MTV008.40c)%2C len: 491 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C highly similar or similar to many Mycobacterial hypothetical proteins e.g. Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from Mycobacterium leprae (491 aa)%2C FASTA scores: opt: 2459%2C E(): 3e-138%2C (75.15%25 identity in 483 aa overlap)%3B O53304|YU87_MYCTU|Rv3087|MTV013.08 from Mycobacterium tuberculosis (472 aa)%2C FASTA scores: opt: 527%2C E(): 8.1e-24%2C (29.1%25 identity in 485 aa overlap)%3B O53305|YU88_MYCTU|Rv3088|MT3173|MTV013.09 from Mycobacterium tuberculosis (474 aa)%2C FASTA scores: opt: 370%2C E(): 1.6e-14%2C (26.05%25 identity in 422 aa overlap)%3B etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2484c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP45278.1;transl_table=11
AL123456.3	EMBL	gene	2792723	2793988	.	-	.	ID=gene-Rv2485c;Name=lipQ;gbkey=Gene;gene=lipQ;gene_biotype=protein_coding;locus_tag=Rv2485c
AL123456.3	EMBL	CDS	2792723	2793988	.	-	0	ID=cds-CCP45279.1;Parent=gene-Rv2485c;Dbxref=EnsemblGenomes-Gn:Rv2485c,EnsemblGenomes-Tr:CCP45279,GOA:I6Y9F7,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:I6Y9F7,NCBI_GP:CCP45279.1;Name=CCP45279.1;Note=Rv2485c%2C (MTV008.41c)%2C len: 421 aa. Probable lipQ%2Ccarboxylesterase protein (lipase). Similar (greater at the C-terminal end) to AAK46626|MT2342 putative carboxylesterase from Mycobacterium tuberculosis strain CDC1551 (431 aa)%2C FASTA scores: opt: 1134%2C E(): 4.3e-60%2C(46.25%25 identity in 428 aa overlap)%3B and Q50681|Rv2284|MTCY339.26c hypothetical protein from M. tuberculosis strain H37Rv (431 aa)%2C FASTA scores: opt: 1134%2C E(): 4.3e-60%2C (46.25%25 identity in 428 aa overlap). Also similar in part to other putative lipases/esterases e.g. AAK44451|MT0230 from Mycobacterium tuberculosis strain CDC1551 (403 aa)%2C FASTA scores: opt: 763%2C E(): 4.6e-38%2C(37.95%25 identity in 390 aa overlap)%3B Q9RY19|DR0133 from Deinococcus radiodurans (296 aa)%2C FASTA scores: opt: 392%2CE(): 4e-16%2C (33.7%25 identity in 276 aa overlap)%3B Q9Z545|SC9B2.14 from Streptomyces coelicolor (502 aa) FASTA scores: opt: 279%2C E(): 3.2e-09%2C (31.15%25 identity in 292 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipQ;locus_tag=Rv2485c;product=Probable carboxylesterase LipQ;protein_id=CCP45279.1;transl_table=11
AL123456.3	EMBL	gene	2794176	2794249	.	+	.	ID=gene-argW;Name=argW;gbkey=Gene;gene=argW;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2794176	2794249	.	+	.	ID=rna-argW;Parent=gene-argW;Note=codon recognized: AGA%3B argW%2C tRNA-Arg%3B anticodon tct%2C length %3D 74;anticodon=(pos:2794210..2794212);gbkey=tRNA;gene=argW;product=tRNA-Arg
AL123456.3	EMBL	exon	2794176	2794249	.	+	.	ID=exon-argW-1;Parent=rna-argW;Note=codon recognized: AGA%3B argW%2C tRNA-Arg%3B anticodon tct%2C length %3D 74;anticodon=(pos:2794210..2794212);gbkey=tRNA;gene=argW;product=tRNA-Arg
AL123456.3	EMBL	gene	2794350	2795120	.	+	.	ID=gene-Rv2486;Name=echA14;gbkey=Gene;gene=echA14;gene_biotype=protein_coding;locus_tag=Rv2486
AL123456.3	EMBL	CDS	2794350	2795120	.	+	0	ID=cds-CCP45280.1;Parent=gene-Rv2486;Dbxref=EnsemblGenomes-Gn:Rv2486,EnsemblGenomes-Tr:CCP45280,GOA:P9WNN5,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,NCBI_GP:CCP45280.1;Name=CCP45280.1;Note=Rv2486%2C (MTV008.42)%2C len: 256 aa. Probable echA14%2Cenoyl-CoA hydratase%2C similar to others e.g. P24162|ECHH_RHOCA2|FADB1 from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa)%2C FASTA scores%3B opt: 453%2C E(): 3.8e-23%2C (39.4%25 identity in 259 aa overlap)%3B Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa)%2C FASTA scores: opt: 404%2C E(): 5.7e-17%2C (37.5%25 identity in 224 aa overlap)%3B P77467|PAAG_ECOLI from Escherichia coli (262 aa)%2CFASTA scores: opt: 401%2C E(): 8.3e-17%2C (36.3%25 identity in 259 aa overlap)%3B etc. Contains PS00166 Enoyl-CoA hydratase/isomerase signature. Belongs to the enoyl-CoA hydratase/isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA14;inference=protein motif:PROSITE:PS00166;locus_tag=Rv2486;product=Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP45280.1;transl_table=11
AL123456.3	EMBL	gene	2795301	2797385	.	-	.	ID=gene-Rv2487c;Name=PE_PGRS42;gbkey=Gene;gene=PE_PGRS42;gene_biotype=protein_coding;locus_tag=Rv2487c
AL123456.3	EMBL	CDS	2795301	2797385	.	-	0	ID=cds-CCP45281.1;Parent=gene-Rv2487c;Dbxref=EnsemblGenomes-Gn:Rv2487c,EnsemblGenomes-Tr:CCP45281,InterPro:IPR000084,UniProtKB/TrEMBL:I6XEF1,NCBI_GP:CCP45281.1;Name=CCP45281.1;Note=Rv2487c%2C (MTV008.43c)%2C len: 694 aa. PE_PGRS42%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of Gly-rich proteins (see citation below)%2Csimilar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa)%2CFASTA scores: opt: 2317%2C E(): 2.3e-84%2C (58.35%25 identity in 622 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS42;locus_tag=Rv2487c;product=PE-PGRS family protein PE_PGRS42;protein_id=CCP45281.1;transl_table=11
AL123456.3	EMBL	gene	2797467	2800880	.	-	.	ID=gene-Rv2488c;Name=Rv2488c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2488c
AL123456.3	EMBL	CDS	2797467	2800880	.	-	0	ID=cds-CCP45282.1;Parent=gene-Rv2488c;Dbxref=EnsemblGenomes-Gn:Rv2488c,EnsemblGenomes-Tr:CCP45282,GOA:O53213,InterPro:IPR000792,InterPro:IPR001054,InterPro:IPR002182,InterPro:IPR011990,InterPro:IPR011991,InterPro:IPR016032,InterPro:IPR027417,InterPro:IPR029787,UniProtKB/TrEMBL:O53213,NCBI_GP:CCP45282.1;Name=CCP45282.1;Note=Rv2488c%2C (MTV008.44c)%2C len: 1137 aa. Probable transcriptional regulatory protein%2C belonging to luxR family%2C similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767%2C E(): 1.8e-211%2C (56.75%25 identity in 1093 aa overlap)%3B O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa)%2C FASTA scores: opt: 3756%2C E(): 7.6e-211%2C (56.75%25 identity in 1089 aa overlap)%3B AAK45665|MT1402 from strain CDC1551 (1159 aa)%2C FASTA scores: opt: 3395%2C E(): 8.2e-190%2C(52.0%25 identity in 1093 aa overlap)%3B etc. Also similar to transcriptional regulatory proteins luxR-family from other organisms e.g. Q9CBP3|ML1753 from Mycobacterium leprae (1106 aa)%2C FASTA scores: opt: 2823%2C E(): 1.5e-156%2C (50.35%25 identity in 1116 aa overlap)%3B Q9KYF4|SCD72A.02 from Streptomyces coelicolor (1114 aa)%2C FASTA scores: opt: 915%2CE(): 1.7e-45%2C (30.7%25 identity in 1143 aa overlap)%3B etc. Some similarity with Q9KXP6|SC9C5.28 hypothetical 81.8 KDA protein from Streptomyces coelicolor (750 aa)%2C FASTA scores: opt: 1085%2C E(): 1.6e-55%2C (35.45%25 identity in 722 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00622 Bacterial regulatory proteins%2C luxR family signature%2C probable coiled-coil from aa 585 to 616 and probable helix-turn-helix motif at aa 1086 to 1107 (score 1206%2C +3.29 SD). Belongs to the LuxR/UhpA family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00622;locus_tag=Rv2488c;product=Probable transcriptional regulatory protein (LuxR-family);protein_id=CCP45282.1;transl_table=11
AL123456.3	EMBL	repeat_region	2800671	2800918	.	+	.	ID=id-AL123456.3:2800671..2800918;Note=248 bp direct repeat 2;gbkey=repeat_region
AL123456.3	EMBL	gene	2800846	2801145	.	-	.	ID=gene-Rv2489c;Name=Rv2489c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2489c
AL123456.3	EMBL	CDS	2800846	2801145	.	-	0	ID=cds-CCP45283.1;Parent=gene-Rv2489c;Dbxref=EnsemblGenomes-Gn:Rv2489c,EnsemblGenomes-Tr:CCP45283,UniProtKB/TrEMBL:O53214,NCBI_GP:CCP45283.1;Name=CCP45283.1;Note=Rv2489c%2C (MTV008.45c)%2C len: 99 aa. Hypothetical unknown ala-rich protein.;gbkey=CDS;locus_tag=Rv2489c;product=Hypothetical alanine rich protein;protein_id=CCP45283.1;transl_table=11
AL123456.3	EMBL	gene	2801254	2806236	.	-	.	ID=gene-Rv2490c;Name=PE_PGRS43;gbkey=Gene;gene=PE_PGRS43;gene_biotype=protein_coding;locus_tag=Rv2490c
AL123456.3	EMBL	CDS	2801254	2806236	.	-	0	ID=cds-CCP45284.1;Parent=gene-Rv2490c;Dbxref=EnsemblGenomes-Gn:Rv2490c,EnsemblGenomes-Tr:CCP45284,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FD4,NCBI_GP:CCP45284.1;Name=CCP45284.1;Note=Rv2490c%2C (MTV008.46c)%2C len: 1660 aa. PE_PGRS43%2CMember of the Mycobacterium tuberculosis PE family%2CPGRS-subfamily of Gly-rich proteins (see Brennan and Delogu%2C 2002)%2C similar to many e.g. AAK47971|MT3612.1 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1551 (1715 aa)%2C FASTA scores: opt: 5161%2C E(): 1.5e-187%2C (51.7%25 identity in 1752 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS43;locus_tag=Rv2490c;product=PE-PGRS family protein PE_PGRS43;protein_id=CCP45284.1;transl_table=11
AL123456.3	EMBL	repeat_region	2806368	2806625	.	+	.	ID=id-AL123456.3:2806368..2806625;Note=258 bp direct repeat 2. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	2806665	2807288	.	+	.	ID=gene-Rv2491;Name=Rv2491;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2491
AL123456.3	EMBL	CDS	2806665	2807288	.	+	0	ID=cds-CCP45285.1;Parent=gene-Rv2491;Dbxref=EnsemblGenomes-Gn:Rv2491,EnsemblGenomes-Tr:CCP45285,InterPro:IPR005268,UniProtKB/TrEMBL:I6XEF6,NCBI_GP:CCP45285.1;Name=CCP45285.1;Note=Rv2491%2C (MTV008.47)%2C len: 207 aa. Conserved hypothetical protein%2C similar in part to other hypothetical proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus (151 aa)%2C FASTA scores: opt: 293%2C E(): 2.8e-11%2C (42.85%25 identity in 126 aa overlap)%3B O66531|AQ_134 from Aquifex aeolicus (151 aa)%2C FASTA scores: opt: 261%2C E(): 2.6e-09%2C(37.75%25 identity in 106 aa overlap)%3B Q9HKU3|TA0501 from Thermoplasma acidophilum (161 aa)%2C FASTA scores: opt: 260%2CE(): 3.2e-09%2C (35.9%25 identity in 117 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2491;product=Conserved hypothetical protein;protein_id=CCP45285.1;transl_table=11
AL123456.3	EMBL	gene	2807278	2808030	.	+	.	ID=gene-Rv2492;Name=Rv2492;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2492
AL123456.3	EMBL	CDS	2807278	2808030	.	+	0	ID=cds-CCP45286.1;Parent=gene-Rv2492;Dbxref=EnsemblGenomes-Gn:Rv2492,EnsemblGenomes-Tr:CCP45286,GOA:I6YDJ7,InterPro:IPR000398,InterPro:IPR023451,UniProtKB/TrEMBL:I6YDJ7,NCBI_GP:CCP45286.1;Name=CCP45286.1;Note=Rv2492%2C (MTV008.48)%2C len: 250 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2492;product=Hypothetical protein;protein_id=CCP45286.1;transl_table=11
AL123456.3	EMBL	gene	2808083	2808304	.	+	.	ID=gene-Rv2493;Name=vapB38;gbkey=Gene;gene=vapB38;gene_biotype=protein_coding;locus_tag=Rv2493
AL123456.3	EMBL	CDS	2808083	2808304	.	+	0	ID=cds-CCP45287.1;Parent=gene-Rv2493;Dbxref=EnsemblGenomes-Gn:Rv2493,EnsemblGenomes-Tr:CCP45287,NCBI_GP:CCP45287.1;Name=CCP45287.1;Note=Rv2493%2C (MTV008.49)%2C len: 73 aa. Possible vapB38%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2494%2Csee Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis strain e.g. Rv3321c|MTV016.21c hypothetical 8.8 KDA protein from Mycobacterium tuberculosis strain H37Rv (80 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB38;locus_tag=Rv2493;product=Possible antitoxin VapB38;protein_id=CCP45287.1;transl_table=11
AL123456.3	EMBL	gene	2808310	2808735	.	+	.	ID=gene-Rv2494;Name=vapC38;gbkey=Gene;gene=vapC38;gene_biotype=protein_coding;locus_tag=Rv2494
AL123456.3	EMBL	CDS	2808310	2808735	.	+	0	ID=cds-CCP45288.1;Parent=gene-Rv2494;Dbxref=EnsemblGenomes-Gn:Rv2494,EnsemblGenomes-Tr:CCP45288,GOA:O53219,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45288.1;Name=CCP45288.1;Note=Rv2494%2C (MTV008.50)%2C len: 141 aa. Possible vapC38%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2493%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. P95023|EMBL:Z83863|MTCY159.26|Rv2530c (139 aa) FASTA scores: opt: 380 E(): 6.6e-19%2C (48.0%25 identity in 125 aa overlap)%3B O53372|Rv3320c|MTV016.20c (142 aa)%2C etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC38;locus_tag=Rv2494;product=Possible toxin VapC38. Contains PIN domain.;protein_id=CCP45288.1;transl_table=11
AL123456.3	EMBL	gene	2808758	2809939	.	-	.	ID=gene-Rv2495c;Name=bkdC;gbkey=Gene;gene=bkdC;gene_biotype=protein_coding;locus_tag=Rv2495c
AL123456.3	EMBL	CDS	2808758	2809939	.	-	0	ID=cds-CCP45289.1;Parent=gene-Rv2495c;Dbxref=EnsemblGenomes-Gn:Rv2495c,EnsemblGenomes-Tr:CCP45289,GOA:O06159,InterPro:IPR000089,InterPro:IPR001078,InterPro:IPR004167,InterPro:IPR011053,InterPro:IPR023213,PDB:3L60,NCBI_GP:CCP45289.1;Name=CCP45289.1;Note=Rv2495c%2C (MTCY07A7.01c-MTV008.51c)%2C len: 393 aa. Probable bkdC%2C branched-chain keto acid dehydrogenase%2C E2 component%2C similar to others e.g. Q9XA49|SCGD3.30c from Streptomyces coelicolor (491 aa) FASTA scores: opt: 615%2CE(): 1.2e-28%2C (36.45%25 identity in 491 aa overlap%3B several gaps)%3B P19262|ODO2_YEAST|KGD2|YDR148C|YD8358.05c from Saccharomyces cerevisiae (Baker's yeast) (463 aa) FASTA scores: opt: 533%2C E(): 7.1e-24%2C (28.55%25 identity in 396 aa overlap)%3B Q9HN75|DSA|VNG2219G from Halobacterium sp. strain NRC-1 (478 aa)%2C FASTA scores: opt: 521%2C E(): E(): 3.7e-23%2C(30.25%25 identity in 486 aa overlap%3B in part)%3B etc. Belongs to the 2-oxoacid dehydrogenase family. Alternative nucleotide at position 2809621 (T->C%3B T107A) has been observed. LpdC|Rv0462 co-immunoprecipitates with DlaT|Rv2215 (in lpdC|Rv0462 mutant) and with BkdC|Rv2495c (in dlaT|Rv2215 mutant) (See Venugopal et al.%2C 2011). Previously known as pdhC.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bkdC;locus_tag=Rv2495c;product=Probable branched-chain keto acid dehydrogenase E2 component BkdC;protein_id=CCP45289.1;transl_table=11
AL123456.3	EMBL	gene	2809936	2810982	.	-	.	ID=gene-Rv2496c;Name=bkdB;gbkey=Gene;gene=bkdB;gene_biotype=protein_coding;locus_tag=Rv2496c
AL123456.3	EMBL	CDS	2809936	2810982	.	-	0	ID=cds-CCP45290.1;Parent=gene-Rv2496c;Dbxref=EnsemblGenomes-Gn:Rv2496c,EnsemblGenomes-Tr:CCP45290,GOA:P9WIS1,InterPro:IPR005475,InterPro:IPR005476,InterPro:IPR009014,InterPro:IPR029061,NCBI_GP:CCP45290.1;Name=CCP45290.1;Note=Rv2496c%2C (MTCY07A7.02c)%2C len: 348 aa. Probable bkdB%2Cbranched-chain keto acid dehydrogenase E1 component%2C beta subunit%2C similar to others e.g. Q9Y8I6||PDHB from Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA scores: opt: 1050%2C E(): 6.4e-60%2C (49.7%25 identity in 324 aa overlap)%3B Q9KG98|BH0214 from Bacillus halodurans (328 aa)%2CFASTA scores: opt: 987%2C E(): 6.9e-56%2C (45.7%25 identity in 324 aa overlap)%3B Q9HN76|PDHB|VNG2218G from Halobacterium sp. strain NRC-1 (297 aa)%2C FASTA scores: opt: 968%2C E(): 1.1e-54%2C (51.2%25 identity in 297 aa overlap)%3B P21874|ODPB_BACST|PDHB pyruvate dehydrogenase E1 component from Bacillus stearothermophilus (324 aa)%2C FASTA scores: opt: 951%2C E(): 1.4e-53%2C (47.6%25 identity in 321 aa overlap)%3B etc. Also similar to Q9XA61|SCGD3.17c putative branched-chain alpha keto acid dehydrogenase E1%2C beta subunit (2-oxoisovalerate dehydrogenase) from Streptomyces coelicolor%2C (326 aa)%2C FASTA scores: opt: 1178%2C E(): 4.1e-68%2C (55.0%25 identity in 322 aa overlap)%3B Q9XA48|SCGD3.31c putative branched-chain alpha keto acid dehydrogenase E1 beta subunit from Streptomyces coelicolor (334 aa)%2C FASTA scores: opt: 1173%2C E(): 8.8e-68%2C (55.6%25 identity in 320 aa overlap)%3B Q53593|BKDB E1-beta branched-chain alpha keto acid dehydrogenase from Streptomyces avermitilis (334 aa)%2C FASTA scores: opt: 1132%2CE(): 3.7e-65%2C (55.0%25 identity in 320 aa overlap)%3B etc. Previously known as pdhB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bkdB;locus_tag=Rv2496c;product=Probable branched-chain keto acid dehydrogenase E1 component%2C beta subunit BkdB;protein_id=CCP45290.1;transl_table=11
AL123456.3	EMBL	gene	2810993	2812096	.	-	.	ID=gene-Rv2497c;Name=bkdA;gbkey=Gene;gene=bkdA;gene_biotype=protein_coding;locus_tag=Rv2497c
AL123456.3	EMBL	CDS	2810993	2812096	.	-	0	ID=cds-CCP45291.1;Parent=gene-Rv2497c;Dbxref=EnsemblGenomes-Gn:Rv2497c,EnsemblGenomes-Tr:CCP45291,GOA:P9WIS3,InterPro:IPR001017,InterPro:IPR017596,InterPro:IPR029061,NCBI_GP:CCP45291.1;Name=CCP45291.1;Note=Rv2497c%2C (MTCY07A7.03c)%2C len: 367 aa. Probable bkdA%2Cbranched-chain keto acid dehydrogenase E1 component%2C alpha subunit%2C similar to many e.g. Q9Y8I5|PDHA from Halobacterium volcanii (Haloferax volcanii) (368 aa) FASTA scores: opt: 961%2C E(): 1.3e-52%2C (45.6%25 identity in 351 aa overlap)%3B BAB40585 from Bacillus sp. UTB2301 (356 aa) FASTA scores: opt: 947%2C E(): 9.1e-52%2C (43.1%25 identity in 355 aa overlap)%3B Q9KG99|BH0213 from Bacillus halodurans (367 aa)%2CFASTA scores: opt: 896%2C E(): 1.4e-48%2C (42.65%25 identity in 340 aa overlap)%3B etc. Also similar to several putative branched-chain alpha keto acid dehydrogenases E1%2C beta subunit%2C alternate name : 2-oxoisovalerate dehydrogenase%2Ce.g. Q53592|BKDA from Streptomyces avermitilis (381 aa)%2CFASTA scores: opt: 980%2C E(): 8.5e-54%2C (45.65%25 identity in 370 aa overlap)%3B etc. Previously known as pdhA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bkdA;locus_tag=Rv2497c;product=Probable branched-chain keto acid dehydrogenase E1 component%2C alpha subunit BkdA;protein_id=CCP45291.1;transl_table=11
AL123456.3	EMBL	gene	2812355	2813176	.	-	.	ID=gene-Rv2498c;Name=citE;gbkey=Gene;gene=citE;gene_biotype=protein_coding;locus_tag=Rv2498c
AL123456.3	EMBL	CDS	2812355	2813176	.	-	0	ID=cds-CCP45292.1;Parent=gene-Rv2498c;Dbxref=EnsemblGenomes-Gn:Rv2498c,EnsemblGenomes-Tr:CCP45292,GOA:P9WPE1,InterPro:IPR005000,InterPro:IPR011206,InterPro:IPR015813,PDB:1U5H,PDB:1U5V,PDB:1Z6K,NCBI_GP:CCP45292.1;Name=CCP45292.1;Note=Rv2498c%2C (MTCY07A7.04c)%2C len: 273 aa. Probable citE%2Ccitrate lyase%2C beta subunit%2C similar to others e.g. Q9S3L3|cite from Corynebacterium glutamicum (Brevibacterium flavum) (217 aa)%2C FASTA scores: opt: 565%2C E(): 1.5e-28%2C(41.85%25 identity in 215 aa overlap)%3B Q9HRM8|cite|VNG0627G from Halobacterium sp. strain NRC-1 (303 aa)%2C FASTA scores: opt: 535%2C E(): 1.5e-26%2C (41.65%25 identity in 276 aa overlap)%3B Q9S2U9|SC4G6.02 from Streptomyces coelicolor (274 aa)%2C FASTA scores: opt: 426%2C E(): 1e-19%2C (37.6%25 identity in 274 aa overlap)%3B P77770|CILB_ECOLI from Escherichia coli (307 aa)%2C FASTA scores: opt: 265%2C E(): 1.5e-10%2C (32.8%25 identity in 265 aa overlap)%3B etc. Also similar to Rv3075c|MTCY22D7.06 from Mycobacterium tuberculosis%2C FASTA score: (35.2%25 identity in 264 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=citE;locus_tag=Rv2498c;product=Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase);protein_id=CCP45292.1;transl_table=11
AL123456.3	EMBL	gene	2813173	2813730	.	-	.	ID=gene-Rv2499c;Name=Rv2499c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2499c
AL123456.3	EMBL	CDS	2813173	2813730	.	-	0	ID=cds-CCP45293.1;Parent=gene-Rv2499c;Dbxref=EnsemblGenomes-Gn:Rv2499c,EnsemblGenomes-Tr:CCP45293,InterPro:IPR002539,InterPro:IPR029069,UniProtKB/TrEMBL:I6Y9H2,NCBI_GP:CCP45293.1;Name=CCP45293.1;Note=Rv2499c%2C (MTCY07A7.05c)%2C len: 185 aa. Possible oxidase regulatory-related protein%2C similar to many maoC monoamine oxidase regulatory protein e.g. Q9RUZ1|DR1239 MAOC-related protein from Deinococcus radiodurans (160 aa)%2CFASTA scores: opt: 519%2C E(): 7.6e-28%2C (58.1%25 identity in 148 aa overlap)%3B BAB48392|MLR0905 Probable monoamine oxidase regulatory protein from Rhizobium loti (Mesorhizobium loti) (150 aa)%2C FASTA scores: opt: 480%2C E(): 2.9e-25%2C (49.0%25 identity in 149 aa overlap)%3B Q9HN18|MAOC1|VNG2290G monoamine oxidase regulatory-like from Halobacterium sp. strain NRC-1 (208 aa)%2C FASTA scores: opt: 419%2C E(): 4.6e-21%2C (45.6%25 identity in 158 aa overlap)%3B P77455|MAOC_ECOLI|PAAZ|B1387 MaoC protein (Phenylacetic acid degradation protein paaZ) from Escherichia coli strain K12 (681 aa)%2C FASTA scores: opt: 252%2C E(): 1.9e-09%2C (36.0%25 identity in 172 aa overlap)%3B etc. But also similar to other proteins with different putative functions e.g. Q9HRM9|MAOC2|VNG0626G molybdenum cofactor biosynthesis protein from Halobacterium sp strain NRC-1 (157 aa)%2C FASTA scores: opt: 380%2C E(): 1.5e-18%2C (45.75%25 identity in 153 aa overlap)%3B Q9KIF1 FKBR2 from Streptomyces hygroscopicus var. ascomyceticus (175 aa)%2C FASTA scores: opt: 355%2C E(): 7.6e-17%2C (42.0%25 identity in 150 aa overlap)%3B CAC36828|Q99Q03|SAPE Spore associated protein from Streptomyces coelicolor (174 aa)%2C FASTA scores: opt: 318%2CE(): 2.2e-14%2C (41.45%25 identity in 152 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2499c;product=Possible oxidase regulatory-related protein;protein_id=CCP45293.1;transl_table=11
AL123456.3	EMBL	gene	2813727	2814911	.	-	.	ID=gene-Rv2500c;Name=fadE19;gbkey=Gene;gene=fadE19;gene_biotype=protein_coding;gene_synonym=mmgC;locus_tag=Rv2500c
AL123456.3	EMBL	CDS	2813727	2814911	.	-	0	ID=cds-CCP45294.1;Parent=gene-Rv2500c;Dbxref=EnsemblGenomes-Gn:Rv2500c,EnsemblGenomes-Tr:CCP45294,GOA:I6Y0W5,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6Y0W5,NCBI_GP:CCP45294.1;Name=CCP45294.1;Note=Rv2500c%2C (MTCY07A7.06c)%2C len: 394 aa. Possible fadE19 (alternate gene name: mmgC)%2C acyl-CoA dehydrogenase%2Csimilar to many e.g. Q9XCG6|ACDH from Streptomyces coelicolor (386 aa)%2C FASTA scores: opt: 1714%2C E(): 1.1e-98%2C(69.45%25 identity in 383 aa overlap)%3B Q9XCG5|ACDH from Streptomyces avermitilis (386 aa)%2C FASTA scores: opt: 1713%2CE(): 1.3e-98%2C (70.0%25 identity in 383 aa overlap)%3B Q9L7W5|FENK from Bacillus subtilis (370 aa)%2C FASTA scores: opt: 1094%2C E(): 2.3e-60%2C (48.4%25 identity in 372 aa overlap)%3B etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1%2C PS00073 Acyl-CoA dehydrogenases signature 2. Belongs to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE19;inference=protein motif:PROSITE:PS00073;locus_tag=Rv2500c;product=Possible acyl-CoA dehydrogenase FadE19 (MMGC);protein_id=CCP45294.1;transl_table=11
AL123456.3	EMBL	gene	2814916	2816880	.	-	.	ID=gene-Rv2501c;Name=accA1;gbkey=Gene;gene=accA1;gene_biotype=protein_coding;gene_synonym=bccA;locus_tag=Rv2501c
AL123456.3	EMBL	CDS	2814916	2816880	.	-	0	ID=cds-CCP45295.1;Parent=gene-Rv2501c;Dbxref=EnsemblGenomes-Gn:Rv2501c,EnsemblGenomes-Tr:CCP45295,GOA:P9WPQ3,InterPro:IPR000089,InterPro:IPR001882,InterPro:IPR005479,InterPro:IPR005481,InterPro:IPR005482,InterPro:IPR011053,InterPro:IPR011054,InterPro:IPR011761,InterPro:IPR011764,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,NCBI_GP:CCP45295.1;Name=CCP45295.1;Note=Rv2501c%2C (MTCY07A7.07c%2C P46401)%2C len: 654 aa. Probable accA1 (alternate gene name: bccA)%2Cacetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [includes: biotin carboxylase %3B biotin carboxyl carrier protein (BCCP)]%2C similar to others eg Q9L076|FABG from Streptomyces coelicolor (646 aa)%2C FASTA scores: opt: 2071%2CE(): 1e-113%2C (57.8%25 identity in 659 aa overlap)%3B AAK24139|Q9A6C6|CC2168 from Caulobacter crescentus (654 aa)%2C FASTA scores: opt: 1754%2C E(): 3.7e-95%2C (47.2%25 identity in 661 aa overlap)%3B etc. Contains PS00188 Biotin-requiring enzymes attachment site%2C PS00866 Carbamoyl-phosphate synthase subdomain signature 1%2C and PS00867 Carbamoyl-phosphate synthase subdomain signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accA1;inference=protein motif:PROSITE:PS00867;locus_tag=Rv2501c;product=Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP);protein_id=CCP45295.1;transl_table=11
AL123456.3	EMBL	gene	2816885	2818474	.	-	.	ID=gene-Rv2502c;Name=accD1;gbkey=Gene;gene=accD1;gene_biotype=protein_coding;locus_tag=Rv2502c
AL123456.3	EMBL	CDS	2816885	2818474	.	-	0	ID=cds-CCP45296.1;Parent=gene-Rv2502c;Dbxref=EnsemblGenomes-Gn:Rv2502c,EnsemblGenomes-Tr:CCP45296,GOA:I6YDK7,InterPro:IPR000022,InterPro:IPR011762,InterPro:IPR011763,InterPro:IPR029045,UniProtKB/TrEMBL:I6YDK7,NCBI_GP:CCP45296.1;Name=CCP45296.1;Note=Rv2502c%2C (MTCY07A7.08c)%2C len: 529 aa. Probable accD1%2C acetyl-/propionyl-CoA carboxylase (beta subunit) %2Csimilar%2C but with N-terminus shorter%2C to Q9L077|ACCD1 from Streptomyces coelicolor (538 aa)%2C FASTA scores: opt: 2747%2CE(): 1.9e-159%2C (77.9%25 identity in 516 aa overlap). Also similar to others e.g. AAK24141|CC2170 from Caulobacter crescentus (530 aa)%2C FASTA scores: opt: 2413%2C E(): 3.8e-139%2C (69.4%25 identity in 529 aa overlap)%3B BAB54131|MLL7731 from Rhizobium loti (537 aa)%2C FASTA scores: opt: 2399%2C E(): 2.7e-138%2C (67.4%25 identity in 527 aa overlap)%3B etc. Could belong to the ACCD/PCCB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accD1;locus_tag=Rv2502c;product=Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1;protein_id=CCP45296.1;transl_table=11
AL123456.3	EMBL	gene	2818471	2819127	.	-	.	ID=gene-Rv2503c;Name=scoB;gbkey=Gene;gene=scoB;gene_biotype=protein_coding;locus_tag=Rv2503c
AL123456.3	EMBL	CDS	2818471	2819127	.	-	0	ID=cds-CCP45297.1;Parent=gene-Rv2503c;Dbxref=EnsemblGenomes-Gn:Rv2503c,EnsemblGenomes-Tr:CCP45297,GOA:P9WPW3,InterPro:IPR004164,InterPro:IPR004165,InterPro:IPR012791,NCBI_GP:CCP45297.1;Name=CCP45297.1;Note=Rv2503c%2C (MTCY07A7.09c%2C MT2578)%2C len: 218 aa. Probable scoB%2C 3-oxo acid:CoA transferase%2C beta subunit (succinyl-CoA:3-ketoacid-CoA transferase). Highly similar to others e.g. Q9XAM8|SC4C6.12c from Streptomyces coelicolor (217 aa)%2C FASTA scores: opt: 1048%2C E(): 2.6e-60%2C(73.9%25 identity in 207 aa overlap)%3B Q9XD82|PCAJ from Streptomyces sp. 2065 (214 aa)%2C FASTA scores: opt: 1031%2CE(): 3.2e-59%2C (70.8%25 identity in 209 aa overlap)%3B AAK53493|LPSJ from Xanthomonas campestris (pv. campestris) (212 aa)%2C FASTA scores: opt: 886%2C E(): 6.6e-50%2C (62.5%25 identity in 208 aa overlap)%3B P42316|SCOB_BACSU from Bacillus subtilis (216 aa)%2C FASTA scores: opt: 820%2C E(): 1.2e-45%2C (58.2%25 identity in 201 aa overlap)%3B etc. Belongs to the 3-oxoacid CoA-transferase subunit B family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=scoB;locus_tag=Rv2503c;product=Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase);protein_id=CCP45297.1;transl_table=11
AL123456.3	EMBL	gene	2819124	2819870	.	-	.	ID=gene-Rv2504c;Name=scoA;gbkey=Gene;gene=scoA;gene_biotype=protein_coding;locus_tag=Rv2504c
AL123456.3	EMBL	CDS	2819124	2819870	.	-	0	ID=cds-CCP45298.1;Parent=gene-Rv2504c;Dbxref=EnsemblGenomes-Gn:Rv2504c,EnsemblGenomes-Tr:CCP45298,GOA:P9WPW5,InterPro:IPR004163,InterPro:IPR004165,InterPro:IPR012792,NCBI_GP:CCP45298.1;Name=CCP45298.1;Note=Rv2504c%2C (MT2579%2C MTCY07A7.10c)%2C len: 248 aa. Probable scoA%2C succinyl-CoA:3-ketoacid-Coenzyme A transferase%2C alpha subunit (3-oxo acid:CoA transferase). Highly similar to others e.g. Q9XAM7|SC4C6.13c from Streptomyces coelicolor (260 aa)%2C FASTA scores: opt: 1130%2CE(): 2.2e-64%2C (69.9%25 identity in 249 aa overlap)%3B Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa)%2C FASTA scores: opt: 1121%2C E(): 8.1e-64%2C (69.5%25 identity in 249 aa overlap)%3B etc. Belongs to the 3-oxoacid CoA-transferase subunit A family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=scoA;locus_tag=Rv2504c;product=Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha subunit) ScoA (3-oxo acid:CoA transferase) (OXCT A) (succinyl-CoA:3-oxoacid-coenzyme A transferase);protein_id=CCP45298.1;transl_table=11
AL123456.3	EMBL	gene	2819953	2821596	.	-	.	ID=gene-Rv2505c;Name=fadD35;gbkey=Gene;gene=fadD35;gene_biotype=protein_coding;locus_tag=Rv2505c
AL123456.3	EMBL	CDS	2819953	2821596	.	-	0	ID=cds-CCP45299.1;Parent=gene-Rv2505c;Dbxref=EnsemblGenomes-Gn:Rv2505c,EnsemblGenomes-Tr:CCP45299,GOA:I6Y0X0,InterPro:IPR000873,InterPro:IPR025110,UniProtKB/TrEMBL:I6Y0X0,NCBI_GP:CCP45299.1;Name=CCP45299.1;Note=Rv2505c%2C (MTCY07A7.11c)%2C len: 547 aa. Probable fadD35%2C fatty-acid-CoA synthetase%2C highly similar to many e.g. Q9Z5A6|SC2G5.17 from Streptomyces coelicolor (541 aa)%2CFASTA scores: opt: 2202%2C E(): 8e-131%2C (61.55%25 identity in 528 aa overlap)%3B Q9F9U4|FADD from Pseudomonas stutzeri (Pseudomonas perfectomarina)%2C FASTA scores: opt: 1551%2C E(): 7.3e-90%2C (55.55%25 identity in 551 aa overlap)%3B Q987S7|MLR6932 from Rhizobium loti (Mesorhizobium loti) (590 aa)%2C FASTA scores: opt: 1453%2C E(): 1.1e-83%2C (50.7%25 identity in 564 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD35;locus_tag=Rv2505c;product=Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP45299.1;transl_table=11
AL123456.3	EMBL	gene	2821712	2822359	.	+	.	ID=gene-Rv2506;Name=Rv2506;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2506
AL123456.3	EMBL	CDS	2821712	2822359	.	+	0	ID=cds-CCP45300.1;Parent=gene-Rv2506;Dbxref=EnsemblGenomes-Gn:Rv2506,EnsemblGenomes-Tr:CCP45300,GOA:O06169,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O06169,NCBI_GP:CCP45300.1;Name=CCP45300.1;Note=Rv2506%2C (MTCY07A7.12)%2C len: 215 aa. Probable transcriptional regulator%2C TetR family%2C similar to many others e.g. Q9L078|SCC105.06c putative TetR-family regulatory protein from Streptomyces coelicolor (208 aa)%2CFASTA scores: opt: 333%2C E(): 1.5e-14%2C (48.75%25 identity in 197 aa overlap)%3B Q9X7X6|SC6A5.30c putative regulatory protein from Streptomyces coelicolor (404 aa)%2C FASTA scores: opt: 267%2C E(): 4.8e-10%2C (30.45%25 identity in 207 aa overlap) (similarity only with C-terminus for this one)%3B Q9FBI8|SCP8.33c putative TetR-family transcriptional regulator from Streptomyces coelicolor (213 aa)%2C FASTA scores: opt: 239%2C E(): 1.8e-08%2C (29.9%25 identity in 184 aa overlap)%3B etc. Also similar to transcriptional regulatory proteins from Mycobacterium tuberculosis e.g. O05858|Rv3208|MTCY07D11.18c (228 aa)%2C FASTA scores: opt: 218%2C E(): 4.4e-07%2C (30.35%25 identity in 191 aa overlap)%3B C-terminus of P95251|Rv1963c|MTV051.01c|MTCY09F9.01 (406 aa)%2C FASTA scores: opt: 238%2C E(): 3.6e-08%2C (28.25%25 identity in 177 aa overlap)%3B P96839|Rv3557c|MTCY06G11.04c (200 aa)%2CFASTA scores: opt: 215%2C E(): 6.2e-07%2C (38.25%25 identity in 148 aa overlap)%3B etc. Equivalent to AAK46885 from Mycobacterium tuberculosis strain CDC1551 (231 aa) but shorter 16 aa. Contains probable helix-turn-helix motif at aa 46-67%2C (Score 1660%2C +4.84 SD). Belongs to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2506;product=Probable transcriptional regulatory protein (probably TetR-family);protein_id=CCP45300.1;transl_table=11
AL123456.3	EMBL	gene	2822438	2823259	.	+	.	ID=gene-Rv2507;Name=Rv2507;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2507
AL123456.3	EMBL	CDS	2822438	2823259	.	+	0	ID=cds-CCP45301.1;Parent=gene-Rv2507;Dbxref=EnsemblGenomes-Gn:Rv2507,EnsemblGenomes-Tr:CCP45301,GOA:O06170,InterPro:IPR008693,UniProtKB/TrEMBL:O06170,NCBI_GP:CCP45301.1;Name=CCP45301.1;Note=Rv2507%2C (MTCY07A7.13)%2C len: 273 aa. Possible conserved pro-rich membrane protein (N-terminal half is Proline-rich)%2C highly similar to Q9CCU3|ML0431 putative membrane protein from Mycobacterium leprae (259 aa) (alias O07711|MLCL383.38c but longer 2 aa)%2C FASTA scores: opt: 968%2C E(): 1.4e-31%2C (60.35%25 identity in 275 aa overlap). Contains potential membrane spanning region. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2507;product=Possible conserved proline rich membrane protein;protein_id=CCP45301.1;transl_table=11
AL123456.3	EMBL	gene	2823256	2824593	.	-	.	ID=gene-Rv2508c;Name=Rv2508c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2508c
AL123456.3	EMBL	CDS	2823256	2824593	.	-	0	ID=cds-CCP45302.1;Parent=gene-Rv2508c;Dbxref=EnsemblGenomes-Gn:Rv2508c,EnsemblGenomes-Tr:CCP45302,InterPro:IPR016196,InterPro:IPR024671,UniProtKB/TrEMBL:O06171,NCBI_GP:CCP45302.1;Name=CCP45302.1;Note=Rv2508c%2C (MTCY07A7.14c)%2C len: 445 aa. Probable conserved integral membrane leu-%2C ala-rich protein%2Cequivalent to Q9CCU4|ML0430 putative membrane protein from Mycobacterium leprae (454 aa) (alias O07710|MLCL383.37 longer 10 aa)%2C FASTA scores: opt: 2205%2C E(): 2.5e-124%2C(75.75%25 identity in 441 aa overlap). Also similar to hypothetical or membrane proteins e.g. BAB50841|MLL4103 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (458 aa)%2C FASTA scores: opt: 396%2C E(): 2.4e-16%2C(27.75%25 identity in 447 aa overlap)%3B Q9RKX9|SC6D7.19c putative integral membrane protein from Streptomyces coelicolor (486 aa)%2C FASTA scores: opt: 323%2C E(): 5.7e-12%2C(28.95%25 identity in 428 aa overlap)%3B P42306|YXIO_BACSU probable integral membrane protein from Bacillus subtilis (428 aa)%2C FASTA scores: opt: 220%2C E(): 7.2e-06%2C (20.35%25 identity in 413 aa overlap)%3B etc. Also similar to proteins from Mycobacterium tuberculosis e.g. Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31.04c (548 aa)%2C FASTA scores: opt: 184%2C E(): 0.0012%2C (24.7%25 identity in 466 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2508c;product=Probable conserved integral membrane leucine and alanine rich protein;protein_id=CCP45302.1;transl_table=11
AL123456.3	EMBL	gene	2824678	2825484	.	+	.	ID=gene-Rv2509;Name=Rv2509;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2509
AL123456.3	EMBL	CDS	2824678	2825484	.	+	0	ID=cds-CCP45303.1;Parent=gene-Rv2509;Dbxref=EnsemblGenomes-Gn:Rv2509,EnsemblGenomes-Tr:CCP45303,GOA:I6Y9I3,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:I6Y9I3,NCBI_GP:CCP45303.1;Name=CCP45303.1;Note=Rv2509%2C (MTCY07A7.15)%2C len: 268 aa. Probable ala-rich oxidoreductase%2C short-chain dehydrogenase/reductase%2C equivalent to O07709|MLCL383.36c|ML0429 dehydrogenase (putative oxidoreductase) from Mycobacterium leprae (268 aa)%2C FASTA scores: opt: 1509%2C E(): 2.6e-84%2C (88.75%25 identity in 267 aa overlap). Also highly similar to others e.g. O86553|SC1F2.16c putative dehydrogenase from Streptomyces coelicolor (276 aa)%2C FASTA scores: opt: 492%2C E(): 9.5e-23%2C(38.15%25 identity in 262 aa overlap)%3B Q9I5R3|PA0658 probable short-chain dehydrogenase from Pseudomonas aeruginosa (266 aa)%2C FASTA scores: opt: 472%2C E(): 1.5e-21%2C (37.8%25 identity in 246 aa overlap)%3B AAK22120|CC0133 oxidoreductase (short-chain dehydrogenase/reductase family) from Caulobacter crescentus (266 aa)%2C FASTA scores: opt: 428%2CE(): 6.9e-19%2C (35.8%25 identity in 243 aa overlap)%3B etc. Also highly similar or similar to oxidoreductases from Mycobacterium tuberculosis e.g. Q10782|Rv1544|MTCY48.21 putative ketoacyl reductase (267 aa)%2C FASTA scores: opt: 656%2C E(): 1.1e-32%2C (43.05%25 identity in 267 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv2509;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP45303.1;transl_table=11
AL123456.3	EMBL	gene	2825488	2827089	.	-	.	ID=gene-Rv2510c;Name=Rv2510c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2510c
AL123456.3	EMBL	CDS	2825488	2827089	.	-	0	ID=cds-CCP45304.1;Parent=gene-Rv2510c;Dbxref=EnsemblGenomes-Gn:Rv2510c,EnsemblGenomes-Tr:CCP45304,InterPro:IPR008571,InterPro:IPR027417,UniProtKB/TrEMBL:I6Y0X6,NCBI_GP:CCP45304.1;Name=CCP45304.1;Note=Rv2510c%2C (MTCY07A7.16c)%2C len: 533 aa. Conserved protein%2C highly similar%2C but longer approximately 20 aa%2C to others e.g. Q9ABY0|CC0090 hypothetical protein from Caulobacter crescentus (516 aa)%2C FASTA scores: opt: 1282%2CE(): 8.4e-63%2C (45.1%25 identity in 490 aa overlap)%3B Q9A130|SPY0500 hypothetical protein from Streptococcus pyogenes (500 aa)%2C FASTA scores: opt: 1281%2C E(): 9.3e-63%2C(43.8%25 identity in 491 aa overlap)%3B Q985L5|MLR7622 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (515 aa)%2C FASTA scores: opt: 1259%2C E(): 1.5e-61%2C(44.1%25 identity in 510 aa overlap)%3B P39342|YJGR_ECOLI|B4263 hypothetical 54.3 KDA protein from Escherichia coli strain K12 (500 aa)%2C FASTA scores: opt: 1257%2C E(): 1.9e-61%2C (42.7%25 identity in 501 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2510c;product=Conserved protein;protein_id=CCP45304.1;transl_table=11
AL123456.3	EMBL	gene	2827157	2827804	.	+	.	ID=gene-Rv2511;Name=orn;gbkey=Gene;gene=orn;gene_biotype=protein_coding;locus_tag=Rv2511
AL123456.3	EMBL	CDS	2827157	2827804	.	+	0	ID=cds-CCP45305.1;Parent=gene-Rv2511;Dbxref=EnsemblGenomes-Gn:Rv2511,EnsemblGenomes-Tr:CCP45305,GOA:P9WIU1,InterPro:IPR006055,InterPro:IPR012337,InterPro:IPR013520,InterPro:IPR022894,NCBI_GP:CCP45305.1;Name=CCP45305.1;Note=Rv2511%2C (MTCY07A7.17)%2C len: 215 aa. Orn%2Coligoribonuclease%2C equivalent to O07708|ORN_MYCLE|ORN|ML0427|MLCL383.34c oligoribonuclease from Mycobacterium leprae (215 aa)%2C FASTA scores: opt: 1170%2C E(): 3.5e-65%2C (84.5%25 identity in 213 aa overlap). Also highly similar to many e.g. P57667|ORN_STRGR|ORNA from Streptomyces griseus (201 aa)%2C FASTA scores: opt: 807%2C E(): 7.7e-43%2C (59.0%25 identity in 200 aa overlap)%3B ORN_STRCO|ORNA|2SC13.01 from Streptomyces coelicolor (200 aa)%2C FASTA scores: opt: 799%2C E(): 2.4e-42%2C (59.7%25 identity in 201 aa overlap)%3B P39287|ORN_ECOLI|B4162 from Escherichia coli strain K12 (180 aa)%2C FASTA scores: opt: 519%2C E(): 3.9e-25%2C (47.4%25 identity in 173 aa overlap)%3B etc. Belongs to the oligoribonuclease family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=orn;locus_tag=Rv2511;product=Oligoribonuclease Orn;protein_id=CCP45305.1;transl_table=11
AL123456.3	EMBL	gene	2827854	2827926	.	+	.	ID=gene-hisT;Name=hisT;gbkey=Gene;gene=hisT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2827854	2827926	.	+	.	ID=rna-hisT;Parent=gene-hisT;Note=codon recognized: CAC%3B hisT%2C tRNA-His%2C anticodon gtg%2C length %3D 73;anticodon=(pos:2827887..2827889);gbkey=tRNA;gene=hisT;product=tRNA-His
AL123456.3	EMBL	exon	2827854	2827926	.	+	.	ID=exon-hisT-1;Parent=rna-hisT;Note=codon recognized: CAC%3B hisT%2C tRNA-His%2C anticodon gtg%2C length %3D 73;anticodon=(pos:2827887..2827889);gbkey=tRNA;gene=hisT;product=tRNA-His
AL123456.3	EMBL	mobile_genetic_element	2828489	2829938	.	-	.	ID=id-AL123456.3:2828489..2829938;Note=IS1081-3%2C len: 1450 nt. Insertion sequence IS1081.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1081-3
AL123456.3	EMBL	gene	2828556	2829803	.	-	.	ID=gene-Rv2512c;Name=Rv2512c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2512c
AL123456.3	EMBL	CDS	2828556	2829803	.	-	0	ID=cds-CCP45306.1;Parent=gene-Rv2512c;Dbxref=EnsemblGenomes-Gn:Rv2512c,EnsemblGenomes-Tr:CCP45306,GOA:P60230,InterPro:IPR001207,NCBI_GP:CCP45306.1;Name=CCP45306.1;Note=Rv2512c%2C (MTCY07A7.18c)%2C len: 415 aa. Transposase for IS1081%2C identical to P35882|TRA1_MYCBO transposase for insertion sequence element IS1081 from Mycobacterium bovis (415 aa)%2C FASTA scores: opt: 2680%2C E(): 1.9e-162%2C (100.0%25 identity in 415 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV01 2.38c (415 aa)%2C FASTA scores: opt: 2675%2C E(): 3.9e-162%2C (99.75%25 identity in 415 aa overlap). Contains PS00435 Peroxidases proximal heme-ligand signature%2C PS01007 Transposases%2CMutator family%2C signature. Belongs to the mutator family of transposase.;gbkey=CDS;inference=protein motif:PROSITE:PS01007;locus_tag=Rv2512c;product=Transposase for insertion sequence element IS1081;protein_id=CCP45306.1;transl_table=11
AL123456.3	EMBL	gene	2830161	2830583	.	+	.	ID=gene-Rv2513;Name=Rv2513;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2513
AL123456.3	EMBL	CDS	2830161	2830583	.	+	0	ID=cds-CCP45307.1;Parent=gene-Rv2513;Dbxref=EnsemblGenomes-Gn:Rv2513,EnsemblGenomes-Tr:CCP45307,UniProtKB/TrEMBL:O06175,NCBI_GP:CCP45307.1;Name=CCP45307.1;Note=Rv2513%2C (MTCY07A7.19)%2C len: 140 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2513;product=Hypothetical protein;protein_id=CCP45307.1;transl_table=11
AL123456.3	EMBL	gene	2830877	2831338	.	-	.	ID=gene-Rv2514c;Name=Rv2514c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2514c
AL123456.3	EMBL	CDS	2830877	2831338	.	-	0	ID=cds-CCP45308.1;Parent=gene-Rv2514c;Dbxref=EnsemblGenomes-Gn:Rv2514c,EnsemblGenomes-Tr:CCP45308,InterPro:IPR016541,InterPro:IPR029060,UniProtKB/TrEMBL:I6Y0Y0,NCBI_GP:CCP45308.1;Name=CCP45308.1;Note=Rv2514c%2C (MTCY07A7.20c)%2C len: 153 aa. Conserved hypothetical protein%2C showing some similarity to Q9PG05|XF0497 hypothetical protein from Xylella fastidiosa (155 aa)%2C FASTA scores: opt: 215%2C E(): 1.4e-07%2C (30.6%25 identity in 160 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2514c;product=Conserved hypothetical protein;protein_id=CCP45308.1;transl_table=11
AL123456.3	EMBL	gene	2831344	2832591	.	-	.	ID=gene-Rv2515c;Name=Rv2515c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2515c
AL123456.3	EMBL	CDS	2831344	2832591	.	-	0	ID=cds-CCP45309.1;Parent=gene-Rv2515c;Dbxref=EnsemblGenomes-Gn:Rv2515c,EnsemblGenomes-Tr:CCP45309,GOA:I6XEH5,InterPro:IPR001387,InterPro:IPR010359,InterPro:IPR010982,UniProtKB/TrEMBL:I6XEH5,NCBI_GP:CCP45309.1;Name=CCP45309.1;Note=Rv2515c%2C (MTCY07A7.21c)%2C len: 415 aa. Conserved hypothetical protein%2C showing some similarity to Q9PG06|XF0496 hypothetical protein from Xylella fastidiosa (391 aa)%2C FASTA scores: opt: 388%2C E(): 4.4e-18%2C (27.8%25 identity in 399 aa overlap). Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature.;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv2515c;product=Conserved hypothetical protein;protein_id=CCP45309.1;transl_table=11
AL123456.3	EMBL	gene	2832710	2833513	.	-	.	ID=gene-Rv2516c;Name=Rv2516c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2516c
AL123456.3	EMBL	CDS	2832710	2833513	.	-	0	ID=cds-CCP45310.1;Parent=gene-Rv2516c;Dbxref=EnsemblGenomes-Gn:Rv2516c,EnsemblGenomes-Tr:CCP45310,UniProtKB/TrEMBL:I6YDM0,NCBI_GP:CCP45310.1;Name=CCP45310.1;Note=Rv2516c%2C (MTV009.01c)%2C len: 267 aa. Hypothetical unknown protein. Contains probable helix-turn-helix motif at aa 98 to 119 (Score 1743%2C +5.12 SD). C-terminus extended since first submission (+ 18 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2516c;product=Hypothetical protein;protein_id=CCP45310.1;transl_table=11
AL123456.3	EMBL	gene	2833510	2833761	.	-	.	ID=gene-Rv2517c;Name=Rv2517c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2517c
AL123456.3	EMBL	CDS	2833510	2833761	.	-	0	ID=cds-CCP45311.1;Parent=gene-Rv2517c;Dbxref=EnsemblGenomes-Gn:Rv2517c,EnsemblGenomes-Tr:CCP45311,UniProtKB/TrEMBL:O53222,NCBI_GP:CCP45311.1;Name=CCP45311.1;Note=Rv2517c%2C (MTV009.02c)%2C len: 83 aa. Unknown protein. Equivalent to AAK46899 from Mycobacterium tuberculosis strain CDC1551 (97 aa) but shorter 14 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2517c;product=Unknown protein;protein_id=CCP45311.1;transl_table=11
AL123456.3	EMBL	gene	2834109	2835335	.	-	.	ID=gene-Rv2518c;Name=ldtB;gbkey=Gene;gene=ldtB;gene_biotype=protein_coding;locus_tag=Rv2518c
AL123456.3	EMBL	CDS	2834109	2835335	.	-	0	ID=cds-CCP45312.1;Parent=gene-Rv2518c;Dbxref=EnsemblGenomes-Gn:Rv2518c,EnsemblGenomes-Tr:CCP45312,GOA:I6Y9J2,InterPro:IPR005490,PDB:3VYN,PDB:3VYO,PDB:3VYP,PDB:4GSQ,PDB:4GSR,PDB:4GSU,PDB:4HU2,PDB:4HUC,NCBI_GP:CCP45312.1;Name=CCP45312.1;Note=Rv2518c%2C (MTV009.03c)%2C len: 408 aa. Probable ldtB%2CL%2CD-transpeptidase%2C highly similar to O07707|MLCL383.3 hypothetical 43.6 KDA protein from Mycobacterium leprae (407 aa)%2C FASTA scores: opt: 2300%2C E(): 1.2e-130%2C (82.5%25 identity in 406 aa overlap)%3B Q9CCU5|LPPS|ML0426 putative secreted protein from Mycobacterium leprae (404 aa)%2C FASTA scores: opt: 2279%2C E(): 2.3e-129%2C (82.4%25 identity in 403 aa overlap)%3B and Q9CB49|ML2446 possible lipoprotein from Mycobacterium leprae (441 aa)%2C FASTA scores: opt: 736%2C E(): 8.4e-37%2C (35.6%25 identity in 399 aa overlap). Also similar to other proteins from several organisms e.g. Q9X811|SC6G10.26c putative secreted protein from Streptomyces coelicolor (424 aa)%2C FASTA scores: opt: 867%2CE(): 1.1e-44%2C (32.25%25 identity in 403 aa overlap)%3B Q9L1E8|SC3D11.14 putative lipoprotein from Streptomyces coelicolor (416 aa)%2C FASTA scores: opt: 737%2C E(): 7e-37%2C(32.95%25 identity in 413 aa overlap)%3B Q9KYV1|SCE22.11 putative lipoprotein from Streptomyces coelicolor (407 aa)%2CFASTA scores: opt: 721%2C E(): 6.2e-36%2C (33.5%25 identity in 400 aa overlap). And similar to several hypothetical mycobacterial proteins e.g. Q11149|Y483_MYCTU|Rv0483|MT0501|MTCY20G9.09 (451 aa)%2C FASTA scores: opt: 763%2C E(): 2.1e-38%2C (34.85%25 identity in 402 aa overlap). Has very long signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as lppS;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ldtB;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2518c;product=Probable L%2CD-transpeptidase LdtB;protein_id=CCP45312.1;transl_table=11
AL123456.3	EMBL	gene	2835494	2835566	.	+	.	ID=gene-lysU;Name=lysU;gbkey=Gene;gene=lysU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2835494	2835566	.	+	.	ID=rna-lysU;Parent=gene-lysU;Note=codon recognized: AAG%3B lysU%2C tRNA-Lys%2C anticodon ctt%2C length %3D 73;anticodon=(pos:2835527..2835529);gbkey=tRNA;gene=lysU;product=tRNA-Lys
AL123456.3	EMBL	exon	2835494	2835566	.	+	.	ID=exon-lysU-1;Parent=rna-lysU;Note=codon recognized: AAG%3B lysU%2C tRNA-Lys%2C anticodon ctt%2C length %3D 73;anticodon=(pos:2835527..2835529);gbkey=tRNA;gene=lysU;product=tRNA-Lys
AL123456.3	EMBL	gene	2835785	2837263	.	+	.	ID=gene-Rv2519;Name=PE26;gbkey=Gene;gene=PE26;gene_biotype=protein_coding;locus_tag=Rv2519
AL123456.3	EMBL	CDS	2835785	2837263	.	+	0	ID=cds-CCP45313.1;Parent=gene-Rv2519;Dbxref=EnsemblGenomes-Gn:Rv2519,EnsemblGenomes-Tr:CCP45313,GOA:Q79FD3,InterPro:IPR000084,InterPro:IPR001969,UniProtKB/TrEMBL:Q79FD3,NCBI_GP:CCP45313.1;Name=CCP45313.1;Note=Rv2519%2C (MTV009.04)%2C len: 492 aa. PE26%2C Member of the M. tuberculosis PE family (see citation below)%2C highly similar to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543 aa)%2CFASTA scores: opt: 848%2C E(): 3e-30%2C (39.55%25 identity in 445 aa overlap).;gbkey=CDS;gene=PE26;locus_tag=Rv2519;product=PE family protein PE26;protein_id=CCP45313.1;transl_table=11
AL123456.3	EMBL	gene	2837388	2837615	.	-	.	ID=gene-Rv2520c;Name=Rv2520c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2520c
AL123456.3	EMBL	CDS	2837388	2837615	.	-	0	ID=cds-CCP45314.1;Parent=gene-Rv2520c;Dbxref=EnsemblGenomes-Gn:Rv2520c,EnsemblGenomes-Tr:CCP45314,InterPro:IPR022062,UniProtKB/TrEMBL:I6XEI0,NCBI_GP:CCP45314.1;Name=CCP45314.1;Note=Rv2520c%2C (MTV009.05c)%2C len: 75 aa. Possible conserved membrane protein%2C equivalent to O07706|MLCL383.32 hypothetical 10.0 KDA protein from Mycobacterium leprae (91 aa)%2C FASTA scores: opt: 290%2C E(): 4.1e-14%2C (58.65%25 identity in 75 aa overlap)%3B and Q9CCU6|ML0425 putative membrane protein from Mycobacterium leprae (75 aa)%2C FASTA scores: opt: 286%2C E(): 6.6e-14%2C (57.35%25 identity in 75 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2520c;product=Possible conserved membrane protein;protein_id=CCP45314.1;transl_table=11
AL123456.3	EMBL	gene	2837684	2838157	.	+	.	ID=gene-Rv2521;Name=bcp;gbkey=Gene;gene=bcp;gene_biotype=protein_coding;locus_tag=Rv2521
AL123456.3	EMBL	CDS	2837684	2838157	.	+	0	ID=cds-CCP45315.1;Parent=gene-Rv2521;Dbxref=EnsemblGenomes-Gn:Rv2521,EnsemblGenomes-Tr:CCP45315,GOA:P9WIE1,InterPro:IPR000866,InterPro:IPR012336,NCBI_GP:CCP45315.1;Name=CCP45315.1;Note=Rv2521%2C (MTV009.06)%2C len: 157 aa. Probable bcp%2Cbacterioferritin comigratory protein%2C equivalent to O07705|BCP|ML0424 from Mycobacterium leprae (161 aa)%2C FASTA scores: opt: 829%2C E(): 6.8e-46%2C (79.6%25 identity in 157 aa overlap). Also highly similar to Q9KZQ2|SCE6.38 hypothetical 16.8 KDA protein Streptomyces coelicolor (155 aa)%2C FASTA scores: opt: 727%2C E(): 2e-39%2C (69.5%25 identity in 154 aa overlap)%3B P23480|AAG57590|BCP_ECOLI|B2480|BAB36765|Z3739|ECS3342 bacterioferritin comigratory protein from Escherichia coli strain K12 (156 aa)%2C FASTA scores: opt: 513%2C E(): 8.3e-26%2C(48.3%25 identity in 149 aa overlap)%3B Q9RW23|DR0846 bacterioferritin comigratory protein from Deinococcus radiodurans (175 aa)%2C FASTA scores: opt: 465%2C E(): 1e-22%2C(46.5%25 identity in 157 aa overlap)%3B P44411|BCP_HAEIN|HI0254 bacterioferritin comigratory protein from Haemophilus influenzae (155 aa)%2C FASTA scores: opt: 453%2C E(): 5.3e-22%2C(47.5%25 identity in 139 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis Rv1608c|MTV046.06|bcpB and Rv2238c|MTCY427.19c|hpE.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bcp;locus_tag=Rv2521;product=Probable bacterioferritin comigratory protein Bcp;protein_id=CCP45315.1;transl_table=11
AL123456.3	EMBL	gene	2838129	2839541	.	-	.	ID=gene-Rv2522c;Name=Rv2522c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2522c
AL123456.3	EMBL	CDS	2838129	2839541	.	-	0	ID=cds-CCP45316.1;Parent=gene-Rv2522c;Dbxref=EnsemblGenomes-Gn:Rv2522c,EnsemblGenomes-Tr:CCP45316,GOA:I6X4J0,InterPro:IPR002933,InterPro:IPR011650,UniProtKB/TrEMBL:I6X4J0,NCBI_GP:CCP45316.1;Name=CCP45316.1;Note=Rv2522c%2C (MTV009.07c)%2C len: 470 aa. Conserved hypothetical protein%2C equivalent%2C but longer 20 aa%2C to Q9X7E4|ML1193|MLCB458.08 from hypothetical 46.6 KDA protein Mycobacterium leprae (442 aa)%2C FASTA scores: opt: 2521%2CE(): 4.1e-142%2C (86.35%25 identity in 440 aa overlap). Also similar to various proteins e.g. Q9K425|SCG22.20 putative peptidase from Streptomyces coelicolor (451 aa)%2C FASTA scores: opt: 1097%2C E(): 1.1e-57%2C (42.5%25 identity in 451 aa overlap)%3B Q9FCK3|2SC3B6.09 putative peptidase from Streptomyces coelicolor (470 aa)%2C FASTA scores: opt: 669%2CE(): 2.8e-32%2C (34.2%25 identity in 462 aa overlap)%3B Q98AF9|MLL6018 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (486 aa)%2C FASTA scores: opt: 622%2C E(): 1.7e-29%2C (33.95%25 identity in 442 aa overlap)%3B Q9RSU7|DR2025 ARGE/DAPE/ACY1 family protein from Deinococcus radiodurans (459 aa)%2C FASTA scores: opt: 616%2C E(): 3.7e-29%2C (34.15%25 identity in 442 aa overlap)%3B etc (include some similarity to hypothetical proteins from C. elegans and yeast). Alternative start possible at 6687 but then no RBS obvious.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2522c;product=Conserved hypothetical protein;protein_id=CCP45316.1;transl_table=11
AL123456.3	EMBL	gene	2839538	2839930	.	-	.	ID=gene-Rv2523c;Name=acpS;gbkey=Gene;gene=acpS;gene_biotype=protein_coding;locus_tag=Rv2523c
AL123456.3	EMBL	CDS	2839538	2839930	.	-	0	ID=cds-CCP45317.1;Parent=gene-Rv2523c;Dbxref=EnsemblGenomes-Gn:Rv2523c,EnsemblGenomes-Tr:CCP45317,GOA:P9WQD3,InterPro:IPR002582,InterPro:IPR004568,InterPro:IPR008278,PDB:3H7Q,PDB:3HQJ,PDB:3NE1,PDB:3NE3,PDB:4HC6,NCBI_GP:CCP45317.1;Name=CCP45317.1;Note=Rv2523c%2C (MT2599%2C MTV009.08c)%2C len: 130 aa. AcpS%2Cholo-[Acyl Carrier Protein] synthase (see citation below)%2Cequivalent to Q9X7E3|ACPS_MYCLE|ML1192|MLCB458.07 holo-[acyl-carrier protein] synthase from Mycobacterium leprae (130 aa)%2C FASTA scores: opt: 732%2C E(): 5.5e-42%2C(87.5%25 identity in 128 aa overlap). Also similar to others e.g. O86785|ACPS_STRCO|SC6G4.22c from Streptomyces coelicolor (123 aa)%2C FASTA scores: opt: 204%2C E(): 6.6e-07%2C(36.7%25 identity in 139 aa overlap)%3B Q9KPB6|VC2457 from Vibrio cholerae (126 aa)%2C FASTA scores: opt: 163%2C E(): 0.00036%2C (32.55%25 identity in 129 aa overlap)%3B P24224|ACPS_ECOLI|DPJ|B2563 from Escherichia coli strain K12 (125 aa)%2C FASTA scores: opt: 151%2C E(): 0.0022%2C (30.55%25 identity in 131 aa overlap)%3B etc. Belongs to the ACPS family. Acts on fas-I enzymes in C. glutamicum (See Chalut et al.%2C 2006).;gbkey=CDS;gene=acpS;locus_tag=Rv2523c;product=holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase);protein_id=CCP45317.1;transl_table=11
AL123456.3	EMBL	gene	2840123	2849332	.	-	.	ID=gene-Rv2524c;Name=fas;gbkey=Gene;gene=fas;gene_biotype=protein_coding;locus_tag=Rv2524c
AL123456.3	EMBL	CDS	2840123	2849332	.	-	0	ID=cds-CCP45318.1;Parent=gene-Rv2524c;Dbxref=EnsemblGenomes-Gn:Rv2524c,EnsemblGenomes-Tr:CCP45318,GOA:P95029,InterPro:IPR001227,InterPro:IPR002539,InterPro:IPR003965,InterPro:IPR013565,InterPro:IPR013785,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR029069,UniProtKB/TrEMBL:P95029,NCBI_GP:CCP45318.1;Name=CCP45318.1;Note=Rv2524c%2C (MTCY159.32%2C MTV009.09c)%2C len: 3069 aa. Probable fas%2C Fatty Acid Synthase%2C equivalent to Q9X7E2|fas|ML1191 putative type I fatty acid synthase from Mycobacterium leprae (3076 aa)%2C FASTA scores: opt: 17484%2CE(): 0%2C (85.8%25 identity in 3081 aa overlap). Also similar to others e.g. Q04846|fas|Q59497 from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (3104 aa)%2C FASTA scores: opt: 3981%2C E(): 5.5e-203%2C (49.8%25 identity in 3099 aa overlap)%3B Q48926|fas from Mycobacterium bovis (2796 aa)%2CFASTA scores: opt: 2098%2C E(): 3.9e-103%2C (59.7%25 identity in 2862 aa overlap) (see Fernandes et al.%2C 1996)%3B P34731|FAS1_CANAL fatty acid synthase subunit beta from Candida albicans (Yeast) (2037 aa)%2C FASTA scores: opt: 955%2CE(): 1.3e-42%2C (27.4%25 identity in 1926 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00606 Beta-ketoacyl synthases active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fas;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2524c;product=Probable fatty acid synthase Fas (fatty acid synthetase);protein_id=CCP45318.1;transl_table=11
AL123456.3	EMBL	gene	2849852	2850574	.	-	.	ID=gene-Rv2525c;Name=Rv2525c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2525c
AL123456.3	EMBL	CDS	2849852	2850574	.	-	0	ID=cds-CCP45319.1;Parent=gene-Rv2525c;Dbxref=EnsemblGenomes-Gn:Rv2525c,EnsemblGenomes-Tr:CCP45319,GOA:I6XEI5,InterPro:IPR006311,InterPro:IPR013781,InterPro:IPR015020,InterPro:IPR017853,InterPro:IPR019546,UniProtKB/TrEMBL:I6XEI5,NCBI_GP:CCP45319.1;Name=CCP45319.1;Note=Rv2525c%2C (MTCY159.31)%2C len: 240 aa. Conserved hypothetical protein%2C equivalent to Q9X7E1|ML1190|MLCB458.05 hypothetical 25.3 KDA protein from Mycobacterium leprae (239 aa)%2C FASTA scores: opt: 1358%2CE(): 1e-75%2C (82.15%25 identity in 241 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2525c;product=Conserved hypothetical protein. Secreted%3B predicted to be a substrate of the twin arginine translocation (tat) export system.;protein_id=CCP45319.1;transl_table=11
AL123456.3	EMBL	gene	2851091	2851318	.	+	.	ID=gene-Rv2526;Name=vapB17;gbkey=Gene;gene=vapB17;gene_biotype=protein_coding;locus_tag=Rv2526
AL123456.3	EMBL	CDS	2851091	2851318	.	+	0	ID=cds-CCP45320.1;Parent=gene-Rv2526;Dbxref=EnsemblGenomes-Gn:Rv2526,EnsemblGenomes-Tr:CCP45320,InterPro:IPR019239,NCBI_GP:CCP45320.1;Name=CCP45320.1;Note=Rv2526%2C (MTCY159.30c)%2C len: 75 aa. Possible vapB17%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2527 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB17;locus_tag=Rv2526;product=Possible antitoxin VapB17;protein_id=CCP45320.1;transl_table=11
AL123456.3	EMBL	gene	2851315	2851716	.	+	.	ID=gene-Rv2527;Name=vapC17;gbkey=Gene;gene=vapC17;gene_biotype=protein_coding;locus_tag=Rv2527
AL123456.3	EMBL	CDS	2851315	2851716	.	+	0	ID=cds-CCP45321.1;Parent=gene-Rv2527;Dbxref=EnsemblGenomes-Gn:Rv2527,EnsemblGenomes-Tr:CCP45321,GOA:P9WF95,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45321.1;Name=CCP45321.1;Note=Rv2527%2C (MTCY159.29c)%2C len: 133 aa. Possible vapC17%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2526%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. P95007|MTCY159.10c|Rv2546 (137 aa)%2C FASTA scores: opt: 206%2C E(): 1.4e-07%2C (38.0%25 identity in 100 aa overlap)%3B O33299|MTV002.22c|Rv2757c (138 aa)%2C FASTA scores: opt: 201%2C E(): 3.1e-07%2C (35.7%25 identity in 126 aa overlap)%3B and P96411|MTCY08D5.24c|Rv0229c (226 aa)%2C FASTA scores: opt: 153%2C E(): 0.0011%2C (32.8%25 identity in 128 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC17;locus_tag=Rv2527;product=Possible toxin VapC17;protein_id=CCP45321.1;transl_table=11
AL123456.3	EMBL	gene	2851751	2852671	.	-	.	ID=gene-Rv2528c;Name=mrr;gbkey=Gene;gene=mrr;gene_biotype=protein_coding;locus_tag=Rv2528c
AL123456.3	EMBL	CDS	2851751	2852671	.	-	0	ID=cds-CCP45322.1;Parent=gene-Rv2528c;Dbxref=EnsemblGenomes-Gn:Rv2528c,EnsemblGenomes-Tr:CCP45322,GOA:I6Y9K2,InterPro:IPR007560,InterPro:IPR011335,InterPro:IPR011856,InterPro:IPR025745,UniProtKB/TrEMBL:I6Y9K2,NCBI_GP:CCP45322.1;Name=CCP45322.1;Note=Rv2528c%2C (MTCY159.28)%2C len: 306 aa. Probable mrr%2Crestriction system protein%2C similar to other mrr proteins e.g. Q9RWS8|DR0587|MRR from Deinococcus radiodurans (306 aa)%2C FASTA scores: opt: 776%2C E(): 4.2e-40%2C (40.45%25 identity in 309 aa overlap)%3B P24202|MRR_ECOLI|B4351 from Escherichia coli strain K12 (304 aa)%2C FASTA scores: opt: 647%2C E(): 2.9e-32%2C (35.25%25 identity in 309 aa overlap)%3B Q9RX07|DR0508 from Deinococcus radiodurans (336 aa)%2C FASTA scores: opt: 456%2C E(): 1.3e-20%2C (37.3%25 identity in 319 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mrr;locus_tag=Rv2528c;product=Probable restriction system protein Mrr;protein_id=CCP45322.1;transl_table=11
AL123456.3	EMBL	gene	2852875	2854266	.	+	.	ID=gene-Rv2529;Name=Rv2529;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2529
AL123456.3	EMBL	CDS	2852875	2854266	.	+	0	ID=cds-CCP45323.1;Parent=gene-Rv2529;Dbxref=EnsemblGenomes-Gn:Rv2529,EnsemblGenomes-Tr:CCP45323,GOA:P95024,InterPro:IPR006166,InterPro:IPR011335,InterPro:IPR020819,InterPro:IPR024412,UniProtKB/TrEMBL:P95024,NCBI_GP:CCP45323.1;Name=CCP45323.1;Note=Rv2529%2C (MTCY159.27c)%2C len: 463 aa. Hypothetical unknown protein. Note that C-terminal part is similar to short region of Q53609|MTS1_STRAL|SALIM modification methylase SALI from Streptomyces albus G (587 aa)%2C FASTA scores: opt: 170%2C E(): 0.016%2C (59.45%25 identity in 37 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2529;product=Hypothetical protein;protein_id=CCP45323.1;transl_table=11
AL123456.3	EMBL	gene	2854267	2854686	.	-	.	ID=gene-Rv2530c;Name=vapC39;gbkey=Gene;gene=vapC39;gene_biotype=protein_coding;locus_tag=Rv2530c
AL123456.3	EMBL	CDS	2854267	2854686	.	-	0	ID=cds-CCP45324.1;Parent=gene-Rv2530c;Dbxref=EnsemblGenomes-Gn:Rv2530c,EnsemblGenomes-Tr:CCP45324,GOA:P9WF63,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45324.1;Name=CCP45324.1;Note=Rv2530c%2C (MTCY159.26)%2C len: 139 aa. Possible vapC39%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2530A%2Ccontains PIN domain%2C see Arcus et al. 2005. Highly similar to others in Mycobacterium tuberculosis e.g. O53219|Rv2494|MTV008.50 (141 aa)%2C FASTA scores: opt: 380%2CE(): 3.6e-19%2C (48.0%25 identity in 125 aa overlap)%3B and O53372|Rv3320c|MTV016.20c (142 aa)%2C FASTA scores: opt: 286%2CE(): 9.3e-13%2C (41.35%25 identity in 133 aa overlap)%3B and similar to others e.g. O07760|Rv0617|MTCY19H5.04c (133 aa)%2CFASTA scores: opt: 158%2C E(): 0.00048%2C (39.55%25 identity in 129 aa overlap). Also some similarity with CAC48798|SMB20412 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (54 aa)%2C FASTA scores: opt: 184%2C E(): 3.7e-06%2C (53.85%25 identity in 52 aa overlap)%3B and CAC48797|SMB20411 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (82 aa)%2C FASTA scores: opt: 170%2CE(): 4.8e-05%2C (44.45%25 identity in 63 aa overlap).;gbkey=CDS;gene=vapC39;locus_tag=Rv2530c;product=Possible toxin VapC39. Contains PIN domain.;protein_id=CCP45324.1;transl_table=11
AL123456.3	EMBL	gene	2854683	2854907	.	-	.	ID=gene-Rv2530A;Name=vapB39;gbkey=Gene;gene=vapB39;gene_biotype=protein_coding;locus_tag=Rv2530A
AL123456.3	EMBL	CDS	2854683	2854907	.	-	0	ID=cds-CCP45325.1;Parent=gene-Rv2530A;Dbxref=EnsemblGenomes-Gn:Rv2530A,EnsemblGenomes-Tr:CCP45325,GOA:P9WJ23,NCBI_GP:CCP45325.1;Name=CCP45325.1;Note=Rv2530A%2C len: 74 aa. Possible vapB39%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv2530c%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. O53218|Rv2493 (73 aa)%2C FASTA scores: opt: 240%2C E(): 5.7e-11%2C (56.75%25 identity in 74 aa overlap)%3B and Q92WE1|RB0399|SMB20413 hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti)p lasmid pSymB (megaplasmid 2) (75 aa)%2C FASTA scores: opt: 226%2C E(): 6.5e-10%2C (56.00%25 identity in 75 aa overlap).;gbkey=CDS;gene=vapB39;locus_tag=Rv2530A;product=Possible antitoxin VapB39;protein_id=CCP45325.1;transl_table=11
AL123456.3	EMBL	gene	2854938	2857781	.	-	.	ID=gene-Rv2531c;Name=Rv2531c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2531c
AL123456.3	EMBL	CDS	2854938	2857781	.	-	0	ID=cds-CCP45326.1;Parent=gene-Rv2531c;Dbxref=EnsemblGenomes-Gn:Rv2531c,EnsemblGenomes-Tr:CCP45326,GOA:I6X4K0,InterPro:IPR000310,InterPro:IPR008286,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:I6X4K0,NCBI_GP:CCP45326.1;Name=CCP45326.1;Note=Rv2531c%2C (MTCY159.25)%2C len: 947 aa. Probable amino acid decarboxylase%2C equivalent to Q9CCR8|adi|ML0524 putative amino acid decarboxylase from Mycobacterium leprae (950 aa)%2C FASTA scores: opt: 5426%2C E(): 0%2C (86.45%25 identity in 951 aa overlap). Also similar to other amino acid decarboxylases (but longer in N-terminus) e.g. Q9I2S7|PA1818 probable ORN/ARG/LYS amino acid decarboxylase from Pseudomonas aeruginosa (751 aa)%2C FASTA scores: opt: 434%2C E(): 2.5e-19%2C (29.15%25 identity in 738 aa overlap)%3B Q9CML3|SPEF|PM0806 ornithine decarboxylase from Pasteurella multocida (720 aa)%2C FASTA scores: opt: 402%2C E(): 2.4e-17%2C(24.85%25 identity in 752 aa overlap)%3B P21169|DCOR_ECOLI|spec|B2965|BAB37264|ECS3841|AAG58096 ornithine decarboxylase isozyme (constitutive enzyme) from Escherichia coli strain K12 (711 aa)%2C FASTA scores: opt: 396%2C E(): 5.6e-17%2C (28.0%25 identity in 646 aa overlap)%3B P44317|DCOR_HAEIN|SPEF|HI0591 ornithine decarboxylase from Haemophilus influenzae (720 aa)%2C FASTA scores: opt: 393%2CE(): 8.8e-17%2C (25.05%25 identity in 743 aa overlap) %3B etc. Seems to belong to family 1 of ornithine%2C lysine%2C and arginine decarboxylases. Note that previously known as adi.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2531c;product=Probable amino acid decarboxylase;protein_id=CCP45326.1;transl_table=11
AL123456.3	EMBL	gene	2857853	2858254	.	-	.	ID=gene-Rv2532c;Name=Rv2532c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2532c
AL123456.3	EMBL	CDS	2857853	2858254	.	-	0	ID=cds-CCP45327.1;Parent=gene-Rv2532c;Dbxref=EnsemblGenomes-Gn:Rv2532c,EnsemblGenomes-Tr:CCP45327,UniProtKB/TrEMBL:P95021,NCBI_GP:CCP45327.1;Name=CCP45327.1;Note=Rv2532c%2C (MTCY159.24)%2C len: 133 aa. Hypothetical unknown protein%2C equivalent to AAK46918 from Mycobacterium tuberculosis strain CDC1551 but shorter 157 aa.;gbkey=CDS;locus_tag=Rv2532c;product=Hypothetical protein;protein_id=CCP45327.1;transl_table=11
AL123456.3	EMBL	gene	2858254	2858724	.	-	.	ID=gene-Rv2533c;Name=nusB;gbkey=Gene;gene=nusB;gene_biotype=protein_coding;locus_tag=Rv2533c
AL123456.3	EMBL	CDS	2858254	2858724	.	-	0	ID=cds-CCP45328.1;Parent=gene-Rv2533c;Dbxref=EnsemblGenomes-Gn:Rv2533c,EnsemblGenomes-Tr:CCP45328,GOA:P9WIV1,InterPro:IPR006027,InterPro:IPR011605,PDB:1EYV,NCBI_GP:CCP45328.1;Name=CCP45328.1;Note=Rv2533c%2C (MT2608%2C MTCY159.23)%2C len: 156 aa. NusB%2C N utilization substance protein (see citations below)%2Cequivalent to Q9CCR9|NUSB_MYCLE|ML0523 N utilization substance protein B from Mycobacterium leprae (190 aa)%2CFASTA scores: opt: 749%2C E(): 2.6e-41%2C (75.7%25 identity in 148 aa overlap). Also highly similar to others e.g. Q9KXR0|SC9C5.14 from Streptomyces coelicolor (142 aa)%2CFASTA scores: opt: 358%2C E(): 2.7e-16%2C (45.0%25 identity in 140 aa overlap)%3B P54520|NUSB_BACSU from Bacillus subtilis (131 aa)%2C FASTA scores: opt: 315%2C E(): 1.5e-13%2C (39.55%25 identity in 129 aa overlap)%3B O83979|NUSB_TREPA|TP1015 from Treponema pallidum (141 aa)%2C FASTA scores: opt: 268%2C E(): 1.6e-10%2C (36.95%25 identity in 138 aa overlap)%3B etc. Belongs to the NusB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nusB;locus_tag=Rv2533c;product=N utilization substance protein NusB (NusB protein);protein_id=CCP45328.1;transl_table=11
AL123456.3	EMBL	gene	2858727	2859290	.	-	.	ID=gene-Rv2534c;Name=efp;gbkey=Gene;gene=efp;gene_biotype=protein_coding;locus_tag=Rv2534c
AL123456.3	EMBL	CDS	2858727	2859290	.	-	0	ID=cds-CCP45329.1;Parent=gene-Rv2534c;Dbxref=EnsemblGenomes-Gn:Rv2534c,EnsemblGenomes-Tr:CCP45329,GOA:P9WNM3,InterPro:IPR001059,InterPro:IPR008991,InterPro:IPR011768,InterPro:IPR012340,InterPro:IPR013185,InterPro:IPR013852,InterPro:IPR014722,InterPro:IPR015365,InterPro:IPR020599,NCBI_GP:CCP45329.1;Name=CCP45329.1;Note=Rv2534c%2C (MTCY159.22)%2C len: 187 aa. Probable efp%2Celongation factor P%2C equivalent to Q9CCS0|EFP|ML0522 elongation factor P from Mycobacterium leprae (187 aa)%2CFASTA scores: opt: 1158%2C E(): 2.1e-67%2C (94.1%25 identity in 186 aa overlap). Also highly similar to many e.g. Q45288|EFP_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (187 aa)%2C FASTA scores: opt: 843%2CE(): 3.4e-47%2C (69.5%25 identity in 187 aa overlap)%3B Q9KXQ9|EFP from Streptomyces coelicolor (188 aa)%2C FASTA scores: opt: 833%2C E(): 1.5e-46%2C (67.0%25 identity in 188 aa overlap)%3B P49778|EFP_BACSU from Bacillus subtilis (185 aa)%2CFASTA scores: opt: 607%2C E(): 4.6e-32%2C (47.8%25 identity in 182 aa overlap)%3B P33398|EFP_ECOLI|B4147 from Escherichia coli strain K12 (187 aa)%2C FASTA scores: opt: 503%2C E(): 1.8e-27%2C (42.3%25 identity in 182 aa overlap)%3B etc. Belongs to the elongation factor P family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=efp;locus_tag=Rv2534c;product=Probable elongation factor P Efp;protein_id=CCP45329.1;transl_table=11
AL123456.3	EMBL	gene	2859300	2860418	.	-	.	ID=gene-Rv2535c;Name=pepQ;gbkey=Gene;gene=pepQ;gene_biotype=protein_coding;locus_tag=Rv2535c
AL123456.3	EMBL	CDS	2859300	2860418	.	-	0	ID=cds-CCP45330.1;Parent=gene-Rv2535c;Dbxref=EnsemblGenomes-Gn:Rv2535c,EnsemblGenomes-Tr:CCP45330,GOA:I6YDN6,InterPro:IPR000587,InterPro:IPR000994,InterPro:IPR001131,InterPro:IPR001714,InterPro:IPR028980,InterPro:IPR029149,UniProtKB/TrEMBL:I6YDN6,NCBI_GP:CCP45330.1;Name=CCP45330.1;Note=Rv2535c%2C (MTCY159.21)%2C len: 372 aa. Probable pepQ%2Ccytoplasmic peptidase%2C equivalent to Q9CCS1|PEPQ|ML0521 putative cytoplasmic peptidase from Mycobacterium leprae (376 aa)%2C FASTA scores: opt: 1954%2C E(): 1.1e-105%2C (82.7%25 identity in 376 aa overlap). Also similar to other peptidases e.g. P54518|YQHT_BACSU putative peptidase (belongs to peptidase family M24B) from Bacillus subtilis (353 aa)%2C FASTA scores: opt: 808%2C E(): 1.6e-39%2C (39.65%25 identity in 368 aa overlap)%3B Q9KXQ8|SC9C5.16c putative peptidase from Streptomyces coelicolor (368 aa)%2C FASTA scores: opt: 803%2C E(): 3.2e-39%2C (43.15%25 identity in 380 aa overlap)%3B Q9K950|BH2800 XAA-pro dipeptidase from Bacillus halodurans (355 aa)%2C FASTA scores: opt: 801%2C E(): 4.1e-39%2C(39.45%25 identity in 365 aa overlap)%3B etc. Note that second part of protein is similar to second part of MTCY49.29c|Rv2089c|MT2150|MTCY49.29c probable dipeptidase%3B belongs to peptidase family M24B from Mycobacterium tuberculosis (375 aa) (33.9%25 identity in 354 aa overlap) blast results: Score: 142 bits (359)%2C E: 4e-33%2C Identities: 86/224 (38%25)%2C Positives: 119/224 (52%25)%2C Gaps: 4/224 (1%25). Could be belong to peptidase family M24B. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepQ;locus_tag=Rv2535c;product=Probable cytoplasmic peptidase PepQ;protein_id=CCP45330.1;transl_table=11
AL123456.3	EMBL	gene	2860452	2861144	.	+	.	ID=gene-Rv2536;Name=Rv2536;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2536
AL123456.3	EMBL	CDS	2860452	2861144	.	+	0	ID=cds-CCP45331.1;Parent=gene-Rv2536;Dbxref=EnsemblGenomes-Gn:Rv2536,EnsemblGenomes-Tr:CCP45331,GOA:P95017,InterPro:IPR009698,UniProtKB/TrEMBL:P95017,NCBI_GP:CCP45331.1;Name=CCP45331.1;Note=Rv2536%2C (MTCY159.20c)%2C len: 230 aa. Probable conserved transmembrane protein%2C equivalent to Q9CCS2|ML0520 putative membrane protein from Mycobacterium leprae (202 aa)%2C FASTA scores: opt: 812%2C E(): 2e-41%2C (63.2%25 identity in 201 aa overlap). Also similar in part to Q9HMD5|VNG2594c from Halobacterium sp. strain NRC-1 (117 aa)%2C FASTA scores: opt: 33.6%2C E(): 1.8%2C (33.6%25 identity in 116 aa overlap)%3B and perhaps AAK65752|SMA1996 putative ABC transporter permease protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (323 aa)%2C FASTA scores: opt: 117%2C E(): 6.1%2C (30.6%25 identity in 121 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2536;product=Probable conserved transmembrane protein;protein_id=CCP45331.1;transl_table=11
AL123456.3	EMBL	gene	2861148	2861591	.	-	.	ID=gene-Rv2537c;Name=aroD;gbkey=Gene;gene=aroD;gene_biotype=protein_coding;gene_synonym=aroQ;locus_tag=Rv2537c
AL123456.3	EMBL	CDS	2861148	2861591	.	-	0	ID=cds-CCP45332.1;Parent=gene-Rv2537c;Dbxref=EnsemblGenomes-Gn:Rv2537c,EnsemblGenomes-Tr:CCP45332,GOA:P9WPX7,InterPro:IPR001874,InterPro:IPR018509,PDB:1H05,PDB:1H0R,PDB:1H0S,PDB:2DHQ,PDB:2XB8,PDB:2Y71,PDB:2Y76,PDB:2Y77,PDB:3N59,PDB:3N76,PDB:3N7A,PDB:3N86,PDB:3N87,PDB:3N8K,PDB:3N8N,PDB:4B6O,PDB:4B6P,PDB:4B6Q,PDB:4CIV,PDB:4CIW,PDB:4CIX,PDB:4CIY,NCBI_GP:CCP45332.1;Name=CCP45332.1;Note=Rv2537c%2C (MTCY159.19)%2C len: 147 aa. AroD (alternate gene name: aroQ)%2C 3-dehydroquinate dehydratase (see citation below)%2C equivalent to Q9CCS3|AROD|ML0519 3-dehydroquinate dehydratase from Mycobacterium leprae (145 aa)%2C FASTA scores: opt: 803%2C E(): 3.4e-46%2C (85.9%25 identity in 142 aa overlap). Also highly similar to many e.g. P96750|AROQ_CORPS from Corynebacterium pseudotuberculosis (146 aa)%2C FASTA scores: opt: 559%2C E(): 4.1e-30%2C (61.05%25 identity in 136 aa overlap)%3B Q9K949|BH2801 from Bacillus halodurans (145 aa)%2C FASTA scores: opt: 453%2C E(): 4e-23%2C(52.15%25 identity in 138 aa overlap)%3B P54517|AROQ_BACSU|YQHS from Bacillus subtilis (148 aa)%2C FASTA scores: opt: 419%2CE(): 7.1e-21%2C (45.3%25 identity in 139 aa overlap)%3B etc. Contains PS01029 Dehydroquinase class II signature. Belongs to the type-II 3-dehydroquinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aroD;inference=protein motif:PROSITE:PS01029;locus_tag=Rv2537c;product=3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase);protein_id=CCP45332.1;transl_table=11
AL123456.3	EMBL	gene	2861588	2862676	.	-	.	ID=gene-Rv2538c;Name=aroB;gbkey=Gene;gene=aroB;gene_biotype=protein_coding;locus_tag=Rv2538c
AL123456.3	EMBL	CDS	2861588	2862676	.	-	0	ID=cds-CCP45333.1;Parent=gene-Rv2538c;Dbxref=EnsemblGenomes-Gn:Rv2538c,EnsemblGenomes-Tr:CCP45333,GOA:P9WPX9,InterPro:IPR016037,PDB:3QBD,PDB:3QBE,NCBI_GP:CCP45333.1;Name=CCP45333.1;Note=Rv2538c%2C (MTCY159.18)%2C len: 362 aa. AroB%2C3-dehydroquinate synthase (see citations below)%2C equivalent to Q9CCS4|AROB_MYCLE|ML0518 3-dehydroquinate synthase from Mycobacterium leprae (361 aa)%2C FASTA scores: opt: 2059%2CE(): 3.3e-117%2C (87.25%25 identity in 361 aa overlap). Also highly similar to many e.g. Q9KXQ6|AROB from Streptomyces coelicolor (363 aa)%2C FASTA scores: opt: 1363%2C E(): 4e-75%2C(60.05%25 identity in 358 aa overlap)%3B Q9X5D2|AROB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (366 aa)%2C FASTA scores: opt: 1154%2C E(): 1.7e-62%2C (50.95%25 identity in 359 aa overlap)%3B P07639|AROB_ECOLI|B3389 from Escherichia coli strain K12 (362 aa)%2C FASTA scores: opt: 771%2C E(): 2.4e-39%2C (40.6%25 identity in 345 aa overlap)%3B etc. Belongs to the dehydroquinate synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aroB;locus_tag=Rv2538c;product=3-dehydroquinate synthase AroB;protein_id=CCP45333.1;transl_table=11
AL123456.3	EMBL	gene	2862673	2863203	.	-	.	ID=gene-Rv2539c;Name=aroK;gbkey=Gene;gene=aroK;gene_biotype=protein_coding;locus_tag=Rv2539c
AL123456.3	EMBL	CDS	2862673	2863203	.	-	0	ID=cds-CCP45334.1;Parent=gene-Rv2539c;Dbxref=EnsemblGenomes-Gn:Rv2539c,EnsemblGenomes-Tr:CCP45334,GOA:P9WPY3,InterPro:IPR000623,InterPro:IPR023000,InterPro:IPR027417,PDB:1L4U,PDB:1L4Y,PDB:1U8A,PDB:1WE2,PDB:1ZYU,PDB:2DFN,PDB:2DFT,PDB:2G1J,PDB:2G1K,PDB:2IYQ,PDB:2IYR,PDB:2IYS,PDB:2IYT,PDB:2IYU,PDB:2IYV,PDB:2IYW,PDB:2IYX,PDB:2IYY,PDB:2IYZ,PDB:3BAF,PDB:4BQS,NCBI_GP:CCP45334.1;Name=CCP45334.1;Note=Rv2539c%2C (MTCY159.17)%2C len: 176 aa. AroK%2C shikimate kinase (see citations below)%2C equivalent to Q9CCS5|AROK|ML0517 putative shikimate kinase from Mycobacterium leprae (199 aa)%2C FASTA scores: opt: 852%2C E(): 1.3e-42%2C (79.65%25 identity in 167 aa overlap). Also highly similar to many e.g. Q9X5D1|AROK_CORG from Corynebacterium glutamicum (Brevibacterium flavum) (169 aa)%2C FASTA scores: opt: 478%2C E(): 5.4e-21%2C (47.0%25 identity in 168 aa overlap)%3B Q9KXQ5|AROK from Streptomyces coelicolor (171 aa)%2C FASTA scores: opt: 465%2C E(): 3.1e-20%2C (49.1%25 identity in 167 aa overlap)%3B P24167|AROK_ECOLI from Escherichia coli strain K12 (172 aa)%2C FASTA scores: opt: 316%2C E(): 1.3e-11%2C (38.4%25 identity in 164 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A%2C and PS01128 Shikimate kinase signature. Belongs to the shikimate kinase family.;gbkey=CDS;gene=aroK;inference=protein motif:PROSITE:PS01128;locus_tag=Rv2539c;product=Shikimate kinase AroK (SK);protein_id=CCP45334.1;transl_table=11
AL123456.3	EMBL	gene	2863207	2864412	.	-	.	ID=gene-Rv2540c;Name=aroF;gbkey=Gene;gene=aroF;gene_biotype=protein_coding;gene_synonym=aroC;locus_tag=Rv2540c
AL123456.3	EMBL	CDS	2863207	2864412	.	-	0	ID=cds-CCP45335.1;Parent=gene-Rv2540c;Dbxref=EnsemblGenomes-Gn:Rv2540c,EnsemblGenomes-Tr:CCP45335,GOA:P9WPY1,InterPro:IPR000453,InterPro:IPR020541,PDB:1ZTB,PDB:2G85,PDB:2O11,PDB:2O12,PDB:2QHF,PDB:4BAI,PDB:4BAJ,NCBI_GP:CCP45335.1;Name=CCP45335.1;Note=Rv2540c%2C (MTCY159.16)%2C len: 401 aa. Probable aroF (alternate gene name: aroC)%2C chorismate synthase%2Cequivalent to Q9CCS6|AROF|ML0516 putative chorismate synthase from Mycobacterium leprae (407 aa)%2C FASTA scores: opt: 2278%2C E(): 6.2e-123%2C (88.05%25 identity in 401 aa overlap). Also highly similar to many e.g. Q9X5D0|AROC_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (410 aa)%2C FASTA scores: opt: 1811%2CE(): 3e-96%2C (70.3%25 identity in 397 aa overlap)%3B Q9KXQ4|AROC_STRCO|AROF|SC9C5.20c from Streptomyces coelicolor (394 aa)%2C FASTA scores: opt: 1710%2C E(): 1.7e-90%2C(67.0%25 identity in 385 aa overlap)%3B Q9KCB7|AROC_BACHD|AROF|BH1656 from Bacillus halodurans (390 aa)%2C FASTA scores: opt: 1196%2C E(): 3.9e-61%2C (48.7%25 identity in 386 aa overlap)%3B etc. Contains PS00788 Chorismate synthase signature 2. Belongs to the chorismate synthase family. Cofactor: reduced flavin%2C NADH;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aroF;inference=protein motif:PROSITE:PS00788;locus_tag=Rv2540c;product=Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase);protein_id=CCP45335.1;transl_table=11
AL123456.3	EMBL	gene	2864427	2864834	.	+	.	ID=gene-Rv2541;Name=Rv2541;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2541
AL123456.3	EMBL	CDS	2864427	2864834	.	+	0	ID=cds-CCP45336.1;Parent=gene-Rv2541;Dbxref=EnsemblGenomes-Gn:Rv2541,EnsemblGenomes-Tr:CCP45336,InterPro:IPR022536,UniProtKB/TrEMBL:P95012,NCBI_GP:CCP45336.1;Name=CCP45336.1;Note=Rv2541%2C (MTCY159.15c)%2C len: 135 aa. Hypothetical unknown ala-rich protein%2C equivalent to AAK46926|MT2615.1 hypothetical 38.9 KDA protein from Mycobacterium tuberculosis strain CDC1551 but AAK46926|MT2615.1 longer at C-terminus. Questionable ORF. Some similarity with Rv2077A from Mycobacterium tuberculosis (99 aa).;gbkey=CDS;locus_tag=Rv2541;product=Hypothetical alanine rich protein;protein_id=CCP45336.1;transl_table=11
AL123456.3	EMBL	gene	2865130	2866341	.	+	.	ID=gene-Rv2542;Name=Rv2542;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2542
AL123456.3	EMBL	CDS	2865130	2866341	.	+	0	ID=cds-CCP45337.1;Parent=gene-Rv2542;Dbxref=EnsemblGenomes-Gn:Rv2542,EnsemblGenomes-Tr:CCP45337,GOA:P95011,InterPro:IPR010427,InterPro:IPR029058,UniProtKB/TrEMBL:P95011,NCBI_GP:CCP45337.1;Name=CCP45337.1;Note=Rv2542%2C (MTCY159.14c)%2C len: 403 aa. Conserved hypothetical protein%2C highly similar to AAK46927|MT2616 hypothetical 28.0 KDA protein from Mycobacterium tuberculosis strain CDC1551 (265 aa)%2C FASTA scores: opt: 1776%2C E(): 2.3e-94%2C (99.25%25 identity in 265 aa overlap). And similar to several hypothetical proteins from Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g. P71654|Rv2797c|MTCY16B7.46 (562 aa)%2C FASTA scores: opt: 537%2C E(): 2.6e-23%2C (40.75%25 identity in 292 aa overlap)%3B P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 (266 aa)%2CFASTA scores: opt: 357%2C E(): 2.6e-13%2C (34.6%25 identity in 234 aa overlap)%3B Q10685|YK77_MYCTU|Rv2077c|MT2137|MTCY49.16c (323 aa)%2C FASTA scores: opt: 261%2C E(): 9.5e-08%2C (32.7%25 identity in 211 aa overlap)%3B etc. Also similar to Q9RDQ9|SC4A7.03 putative secreted protein from Streptomyces coelicolor (406 aa)%2CFASTA scores: opt: 247%2C E(): 7.3e-07%2C (30.35%25 identity in 303 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2542;product=Conserved hypothetical protein;protein_id=CCP45337.1;transl_table=11
AL123456.3	EMBL	gene	2866468	2867127	.	+	.	ID=gene-Rv2543;Name=lppA;gbkey=Gene;gene=lppA;gene_biotype=protein_coding;locus_tag=Rv2543
AL123456.3	EMBL	CDS	2866468	2867127	.	+	0	ID=cds-CCP45338.1;Parent=gene-Rv2543;Dbxref=EnsemblGenomes-Gn:Rv2543,EnsemblGenomes-Tr:CCP45338,GOA:P9WK81,PDB:2V7S,NCBI_GP:CCP45338.1;Name=CCP45338.1;Note=Rv2543%2C (MTCY159.13c)%2C len: 219 aa. Probable lppA%2Cconserved lipoprotein%2C highly similar to upstream ORF P95009|LPPB|Rv2544|MTCY159.12 putative lipoprotein LPPB from Mycobacterium tuberculosis (220 aa)%2C FASTA scores: opt: 1240%2C E(): 1.1e-73%2C (87.15%25 identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lppA;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2543;product=Probable conserved lipoprotein LppA;protein_id=CCP45338.1;transl_table=11
AL123456.3	EMBL	gene	2867124	2867786	.	+	.	ID=gene-Rv2544;Name=lppB;gbkey=Gene;gene=lppB;gene_biotype=protein_coding;locus_tag=Rv2544
AL123456.3	EMBL	CDS	2867124	2867786	.	+	0	ID=cds-CCP45339.1;Parent=gene-Rv2544;Dbxref=EnsemblGenomes-Gn:Rv2544,EnsemblGenomes-Tr:CCP45339,GOA:P9WK79,NCBI_GP:CCP45339.1;Name=CCP45339.1;Note=Rv2544%2C (MTCY159.12c)%2C len: 220 aa. Probable lppB%2Cconserved lipoprotein%2C highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 putative lipoprotein LPPA from Mycobacterium tuberculosis (219 aa)%2CFASTA scores: opt: 1242%2C E(): 4.8e-72%2C (87.15%25 identity in 218 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppB;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2544;product=Probable conserved lipoprotein LppB;protein_id=CCP45339.1;transl_table=11
AL123456.3	EMBL	gene	2867783	2868061	.	+	.	ID=gene-Rv2545;Name=vapB18;gbkey=Gene;gene=vapB18;gene_biotype=protein_coding;locus_tag=Rv2545
AL123456.3	EMBL	CDS	2867783	2868061	.	+	0	ID=cds-CCP45340.1;Parent=gene-Rv2545;Dbxref=EnsemblGenomes-Gn:Rv2545,EnsemblGenomes-Tr:CCP45340,InterPro:IPR019239,NCBI_GP:CCP45340.1;Name=CCP45340.1;Note=Rv2545%2C (MTY159.11c)%2C len: 92 aa. Possible vapB18%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2546 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. O33300|Rv2758c|MTV002.23c (88 aa)%2C FASTA scores: opt: 151%2CE(): 9.8e-05%2C (66.65%25 identity in 45 aa overlap)%3B and Q10771|Rv1560|MT1611|MTCY48.05 (72 aa)%2C FASTA scores: opt: 84%2C E(): 8.2%2C (46.5%25 identity in 43 aa overlap).;gbkey=CDS;gene=vapB18;locus_tag=Rv2545;product=Possible antitoxin VapB18;protein_id=CCP45340.1;transl_table=11
AL123456.3	EMBL	gene	2868154	2868567	.	+	.	ID=gene-Rv2546;Name=vapC18;gbkey=Gene;gene=vapC18;gene_biotype=protein_coding;locus_tag=Rv2546
AL123456.3	EMBL	CDS	2868154	2868567	.	+	0	ID=cds-CCP45341.1;Parent=gene-Rv2546;Dbxref=EnsemblGenomes-Gn:Rv2546,EnsemblGenomes-Tr:CCP45341,GOA:P95007,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45341.1;Name=CCP45341.1;Note=Rv2546%2C (MTCY159.10c)%2C len: 137 aa. Possible vapC18%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2545%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. P96411|Rv0229c|MTCY08D5.24c (226 aa)%2CFASTA scores: opt: 272%2C E(): 1.3e-11%2C (39.7%25 identity in 136 aa overlap)%3B O33299|Rv2757c|MTV002.22c (138 aa)%2C FASTA scores: opt: 265%2C E(): 2.5e-11%2C (38.5%25 identity in 135 aa overlap)%3B P95026|Rv2527|MTCY159.29c (133 aa)%2C FASTA scores: opt: 206%2C E(): 2.6e-07%2C (38.0%25 identity in 100 aa overlap)%3B etc.;gbkey=CDS;gene=vapC18;locus_tag=Rv2546;product=Possible toxin VapC18;protein_id=CCP45341.1;transl_table=11
AL123456.3	EMBL	gene	2868606	2868863	.	+	.	ID=gene-Rv2547;Name=vapB19;gbkey=Gene;gene=vapB19;gene_biotype=protein_coding;locus_tag=Rv2547
AL123456.3	EMBL	CDS	2868606	2868863	.	+	0	ID=cds-CCP45342.1;Parent=gene-Rv2547;Dbxref=EnsemblGenomes-Gn:Rv2547,EnsemblGenomes-Tr:CCP45342,GOA:P95006,InterPro:IPR002145,InterPro:IPR010985,NCBI_GP:CCP45342.1;Name=CCP45342.1;Note=Rv2547%2C (MTCY159.09c)%2C len: 85 aa. Possible vapB19%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2548 (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. P71666|YD98_MYCTU|Rv1398c|MT1442|MTCY21B4.15c hypothetical 9.4 KDA protein from (85 aa)%2C FASTA scores: opt: 108%2C E(): 0.33%2C (37.1%25 identity in 62 aa overlap)%3B and to CAC45864|SMC01933 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (71 aa)%2C FASTA scores: opt: 105%2C E(): 0.46%2C (28.4%25 identity in 74 aa overlap)%3B Q97W38|SSO10342 hypothetical protein from Sulfolobus solfataricus (58 aa)%2C FASTA scores: opt: 94%2CE(): 2.3%2C (46.95%25 identity in 49 aa overlap).;gbkey=CDS;gene=vapB19;locus_tag=Rv2547;product=Possible antitoxin VapB19;protein_id=CCP45342.1;transl_table=11
AL123456.3	EMBL	gene	2868860	2869237	.	+	.	ID=gene-Rv2548;Name=vapC19;gbkey=Gene;gene=vapC19;gene_biotype=protein_coding;locus_tag=Rv2548
AL123456.3	EMBL	CDS	2868860	2869237	.	+	0	ID=cds-CCP45343.1;Parent=gene-Rv2548;Dbxref=EnsemblGenomes-Gn:Rv2548,EnsemblGenomes-Tr:CCP45343,GOA:P9WF93,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45343.1;Name=CCP45343.1;Note=Rv2548%2C (MTCY159.08c)%2C len: 125 aa. Possible vapC19%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2547%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similarity to others in Mycobacterium tuberculosis e.g. P71665|Rv1397c|MTCY21B4.14c hypothetical 15.0 KDA protein (133 aa)%2C FASTA scores: opt: 265%2C E(): 7.1e-12%2C (42.3%25 identity in 123 aa overlap)%3B and to Q97WY5|SSO1975 hypothetical protein from Sulfolobus solfataricus (125 aa)%2C FASTA scores: opt: 131%2C E(): 0.018%2C(30.0%25 identity in 110 aa overlap)%3B O52285|YLE hypothetical 14.9 KDA protein from Agrobacterium radiobacter (133 aa)%2CFASTA scores: opt: 128%2C E(): 0.03%2C (32.8%25 identity in 125 aa overlap)%3B etc.;gbkey=CDS;gene=vapC19;locus_tag=Rv2548;product=Possible toxin VapC19;protein_id=CCP45343.1;transl_table=11
AL123456.3	EMBL	gene	2869253	2869627	.	-	.	ID=gene-Rv2548A;Name=Rv2548A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2548A
AL123456.3	EMBL	CDS	2869253	2869627	.	-	0	ID=cds-CCP45344.1;Parent=gene-Rv2548A;Dbxref=EnsemblGenomes-Gn:Rv2548A,EnsemblGenomes-Tr:CCP45344,UniProtKB/TrEMBL:I6XEK2,NCBI_GP:CCP45344.1;Name=CCP45344.1;Note=Rv2548A%2C len: 124 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2548A;product=Conserved protein;protein_id=CCP45344.1;transl_table=11
AL123456.3	EMBL	gene	2869727	2870122	.	-	.	ID=gene-Rv2549c;Name=vapC20;gbkey=Gene;gene=vapC20;gene_biotype=protein_coding;locus_tag=Rv2549c
AL123456.3	EMBL	CDS	2869727	2870122	.	-	0	ID=cds-CCP45345.1;Parent=gene-Rv2549c;Dbxref=EnsemblGenomes-Gn:Rv2549c,EnsemblGenomes-Tr:CCP45345,GOA:P95004,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45345.1;Name=CCP45345.1;Note=Rv2549c%2C (MTCY159.07)%2C len: 131 aa. Possible vapC20%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2550c%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Conserved hypothetical protein%2C showing some similarity to P73415|SLL1715 from Synechocystis sp. strain PCC 6803 (157 aa)%2C FASTA scores: opt: 167%2C E(): 4.2e-05%2C(29.45%25 identity in 129 aa overlap)%3B Q9HHY6|VNG6166H from Halobacterium sp. plasmid pNRC200 strain NRC-1 (144 aa)%2CFASTA scores: opt: 133%2C E(): 0.011%2C (29.6%25 identity in 125 aa overlap)%3B and Q9HSU3|VNG0072H from Halobacterium sp. strain NRC-1 (144 aa)%2C FASTA scores: opt: 113%2C E(): 0.29%2C(25.75%25 identity in 136 aa overlap).;gbkey=CDS;gene=vapC20;locus_tag=Rv2549c;product=Possible toxin VapC20;protein_id=CCP45345.1;transl_table=11
AL123456.3	EMBL	gene	2870119	2870364	.	-	.	ID=gene-Rv2550c;Name=vapB20;gbkey=Gene;gene=vapB20;gene_biotype=protein_coding;locus_tag=Rv2550c
AL123456.3	EMBL	CDS	2870119	2870364	.	-	0	ID=cds-CCP45346.1;Parent=gene-Rv2550c;Dbxref=EnsemblGenomes-Gn:Rv2550c,EnsemblGenomes-Tr:CCP45346,GOA:P9WJ45,InterPro:IPR002145,NCBI_GP:CCP45346.1;Name=CCP45346.1;Note=Rv2550c%2C (MTCY159.06)%2C len: 81 aa. Possible vapB20%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2549c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Some similarity to others in M. tuberculosis e.g. Rv0581;gbkey=CDS;gene=vapB20;locus_tag=Rv2550c;product=Possible antitoxin VapB20;protein_id=CCP45346.1;transl_table=11
AL123456.3	EMBL	gene	2870775	2871194	.	-	.	ID=gene-Rv2551c;Name=Rv2551c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2551c
AL123456.3	EMBL	CDS	2870775	2871194	.	-	0	ID=cds-CCP45347.1;Parent=gene-Rv2551c;Dbxref=EnsemblGenomes-Gn:Rv2551c,EnsemblGenomes-Tr:CCP45347,GOA:I6Y9M6,InterPro:IPR000045,UniProtKB/TrEMBL:I6Y9M6,NCBI_GP:CCP45347.1;Name=CCP45347.1;Note=Rv2551c%2C (MTCY159.05)%2C len: 139 aa. Conserved hypothetical protein%2C similar to the second part of Q9XAP1|SC10A7.34c putative type IV peptidase from Streptomyces coelicolor (259 aa)%2C FASTA scores: opt: 243%2CE(): 7.4e-08%2C (40.95%25 identity in 144 aa overlap). Also some similarity with other proteins e.g. AAK58497|GSPO GSPO protein from Acetobacter diazotrophicus (261 aa)%2C FASTA scores: opt: 152%2C E(): 0.025%2C (33.35%25 identity in 135 aa overlap).;gbkey=CDS;locus_tag=Rv2551c;product=Conserved hypothetical protein;protein_id=CCP45347.1;transl_table=11
AL123456.3	EMBL	gene	2871206	2872015	.	-	.	ID=gene-Rv2552c;Name=aroE;gbkey=Gene;gene=aroE;gene_biotype=protein_coding;locus_tag=Rv2552c
AL123456.3	EMBL	CDS	2871206	2872015	.	-	0	ID=cds-CCP45348.1;Parent=gene-Rv2552c;Dbxref=EnsemblGenomes-Gn:Rv2552c,EnsemblGenomes-Tr:CCP45348,GOA:I6Y120,InterPro:IPR006151,InterPro:IPR010110,InterPro:IPR013708,InterPro:IPR016040,UniProtKB/TrEMBL:I6Y120,NCBI_GP:CCP45348.1;Name=CCP45348.1;Note=Rv2552c%2C (MTCY159.04)%2C len: 269 aa. Probable aroE%2Cshikimate 5-dehydrogenase%2C equivalent to Q9CCS7|AROE|ML0515 putative shikimate 5-dehydrogenase from Mycobacterium leprae (278 aa)%2C FASTA scores: opt: 1452%2C E(): 1.8e-77%2C(81.5%25 identity in 270 aa overlap). Also highly similar%2Cbut longer 101 aa%2C to Q9KH59|AROE putative shikimate dehydrogenase (fragment) from Mycobacterium marinum (148 aa)%2C FASTA scores: opt: 729%2C E(): 1.3e-35%2C (76.35%25 identity in 148 overlap)%3B Q9F7W3|AROE from Mycobacterium ulcerans (148 aa)%2C FASTA scores: opt: 718%2C E(): 5.9e-35%2C (75.7%25 identity in 148 aa overlap). And also similar to to others e.g. Q9KXQ2|AROE from Streptomyces coelicolor (255 aa)%2CFASTA scores: opt: 572%2C E(): 2.8e-26%2C (43.4%25 identity in 251 aa overlap)%3B Q98DY3|MLR4492 from Rhizobium loti (Mesorhizobium loti) (280 aa)%2C FASTA scores: opt: 385%2C E(): 2.2e-15%2C (34.85%25 identity in 284 aa overlap)%3B P74591|AROE_SYNY3|SLR1559 from Synechocystis sp. strain PCC 6803 (290 aa)%2C FASTA scores: opt: 347%2C E(): 3.7e-13%2C (30.9%25 identity in 275 aa overlap)%3B P15770|AROE_ECOLI|B3281 from Escherichia coli strain K12 (272 aa)%2C FASTA scores: opt: 230%2C E(): 7.7e-08%2C (29.5%25 identity in 251 aa overlap)%3B etc. Belongs to the shikimate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aroE;locus_tag=Rv2552c;product=Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase);protein_id=CCP45348.1;transl_table=11
AL123456.3	EMBL	gene	2872012	2873265	.	-	.	ID=gene-Rv2553c;Name=Rv2553c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2553c
AL123456.3	EMBL	CDS	2872012	2873265	.	-	0	ID=cds-CCP45349.1;Parent=gene-Rv2553c;Dbxref=EnsemblGenomes-Gn:Rv2553c,EnsemblGenomes-Tr:CCP45349,InterPro:IPR003770,UniProtKB/TrEMBL:I6XEK6,NCBI_GP:CCP45349.1;Name=CCP45349.1;Note=Rv2553c%2C (MTCY159.03)%2C len: 417 aa. Probable conserved membrane protein%2C equivalent to Q9CCS8|ML0514 putative membrane protein from Mycobacterium leprae (421 aa)%2C FASTA scores: opt: 1955%2C E(): 1.1e-111%2C (72.7%25 identity in 414 aa overlap). Also similar in part to various proteins e.g. Q9L9G6|NOVB NOVB protein (aminodesoxychorismate lyase) from Streptomyces sphaeroides (284 aa)%2C FASTA scores: opt: 451%2C E(): 2.9e-2%2C (37.95%25 identity in 203 aa overlap)%3B Q9EWY3|2SCG38.36 conserved hypothetical protein from Streptomyces coelicolor (253 aa)%2CFASTA scores: opt: 419%2C E(): 2.3e-18%2C (39.2%25 identity in 171 aa overlap)%3B Q9CHT3|YGCC hypothetical protein from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (550 aa)%2C FASTA scores: opt: 379%2C E(): 1.2e-15%2C (23.0%25 identity in 417 aa overlap)%3B O25309|HP0587 aminodeoxychorismate lyase (PABC) from Helicobacter pylori (Campylobacter pylori) (329 aa)%2C FASTA scores: opt: 290%2CE(): 2e-10%2C (31.65%25 identity in 180 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2553c;product=Probable conserved membrane protein;protein_id=CCP45349.1;transl_table=11
AL123456.3	EMBL	gene	2873258	2873770	.	-	.	ID=gene-Rv2554c;Name=Rv2554c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2554c
AL123456.3	EMBL	CDS	2873258	2873770	.	-	0	ID=cds-CCP45350.1;Parent=gene-Rv2554c;Dbxref=EnsemblGenomes-Gn:Rv2554c,EnsemblGenomes-Tr:CCP45350,GOA:P9WGV7,InterPro:IPR005227,InterPro:IPR006641,InterPro:IPR012337,NCBI_GP:CCP45350.1;Name=CCP45350.1;Note=Rv2554c%2C (MTCY159.02)%2C len: 170 aa. Conserved protein%2C equivalent to Q9CCS9|ML0513 hypothetical protein from Mycobacterium leprae (184 aa)%2C FASTA scores: opt: 701%2CE(): 2e-34%2C (72.05%25 identity in 161 aa overlap). Also highly similar to Q9KXQ0|SC9C5.24c hypothetical 17.7 KDA protein from Streptomyces coelicolor (167 aa)%2C FASTA scores: opt: 461%2C E(): 2.3e-20%2C (54.65%25 identity in 150 aa overlap)%3B and similar to other hypothetical proteins e.g. Q9KDE4 from Bacillus halodurans (140 aa)%2C FASTA scores: opt: 291%2C E(): 1.9e-10%2C (38.7%25 identity in 137 aa overlap)%3B P74662|SLL1547 from Synechocystis sp. strain PCC 6803 (152 aa)%2C FASTA scores: opt: 290%2C (36.55%25 identity in 145 aa overlap)%3B Q52673|YQGF_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (159 aa)%2C FASTA scores: opt: 246%2C E(): 8.4e-08%2C (34.8%25 identity in 135 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2554c;product=Conserved protein;protein_id=CCP45350.1;transl_table=11
AL123456.3	EMBL	gene	2873771	2876485	.	-	.	ID=gene-Rv2555c;Name=alaS;gbkey=Gene;gene=alaS;gene_biotype=protein_coding;locus_tag=Rv2555c
AL123456.3	EMBL	CDS	2873771	2876485	.	-	0	ID=cds-CCP45351.1;Parent=gene-Rv2555c;Dbxref=EnsemblGenomes-Gn:Rv2555c,EnsemblGenomes-Tr:CCP45351,GOA:P9WFW7,InterPro:IPR002318,InterPro:IPR003156,InterPro:IPR009000,InterPro:IPR012947,InterPro:IPR018162,InterPro:IPR018163,InterPro:IPR018164,InterPro:IPR018165,InterPro:IPR023033,NCBI_GP:CCP45351.1;Name=CCP45351.1;Note=Rv2555c%2C (MTCY318.01c-MTCY159.01)%2C len: 904 aa. Probable alaS%2C alanyl-tRNA synthetase%2C equivalent to Q9CCT0|alas|ML0512 alanyl-tRNA synthetase from Mycobacterium leprae (908 aa)%2C FASTA scores: opt: 5013%2CE(): 0%2C (84.65%25 identity in 907 aa overlap). Also highly similar to many e.g. Q9KXP9|alas from Streptomyces coelicolor (890 aa)%2C FASTA scores: opt: 2159%2C E(): 3.8e-118%2C (53.45%25 identity in 907 aa overlap)%3B Q9FFC7 Arabidopsis thaliana (Mouse-ear cress) (954 aa)%2C FASTA scores: opt: 1963%2C E(): 1.1e-106%2C (41.1%25 identity in 925 aa overlap)%3B Q9RS27|DR2300 from Deinococcus radiodurans (890 aa)%2C FASTA scores: opt: 1352%2C E(): 4.1e-71%2C (38.05%25 identity in 915 aa overlap)%3B etc. Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=alaS;locus_tag=Rv2555c;product=Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS);protein_id=CCP45351.1;transl_table=11
AL123456.3	EMBL	gene	2876576	2876965	.	-	.	ID=gene-Rv2556c;Name=Rv2556c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2556c
AL123456.3	EMBL	CDS	2876576	2876965	.	-	0	ID=cds-CCP45352.1;Parent=gene-Rv2556c;Dbxref=EnsemblGenomes-Gn:Rv2556c,EnsemblGenomes-Tr:CCP45352,GOA:P9WFP9,InterPro:IPR001602,NCBI_GP:CCP45352.1;Name=CCP45352.1;Note=Rv2556c%2C (MTCY09C4.12)%2C len: 129 aa. Conserved hypothetical protein%2C highly similar to others e.g. Q9EWY5|2SCG38.34 conserved hypothetical protein from Streptomyces coelicolor (140 aa)%2C FASTA scores: opt: 488%2CE(): 8.2e-26%2C (58.8%25 identity in 131 aa overlap)%3B Q9L9G4|NOVD NOVD protein from Streptomyces sphaeroides (143 aa)%2C FASTA scores: opt: 474%2C E(): 7.2e-25%2C (60.85%25 identity in 120 aa overlap)%3B Q9X2I5|TM1872 from Thermotoga maritima (132 aa)%2C FASTA scores: opt: 270%2C E(): 2.7e-11%2C (39.55%25 identity in 129 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2556c;product=Conserved hypothetical protein;protein_id=CCP45352.1;transl_table=11
AL123456.3	EMBL	gene	2877072	2877746	.	+	.	ID=gene-Rv2557;Name=Rv2557;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2557
AL123456.3	EMBL	CDS	2877072	2877746	.	+	0	ID=cds-CCP45353.1;Parent=gene-Rv2557;Dbxref=EnsemblGenomes-Gn:Rv2557,EnsemblGenomes-Tr:CCP45353,GOA:P9WLA5,InterPro:IPR011008,NCBI_GP:CCP45353.1;Name=CCP45353.1;Note=Rv2557%2C (MTCY9C4.11c)%2C len: 224 aa. Conserved protein%2C highly similar to upstream ORF Q50740|MTCY9C4.10c|Rv2558|MT2635 conserved hypothetical protein from Mycobacterium tuberculosis (236 aa)%2C FASTA scores: opt: 1007%2C E(): 6.9e-60%2C (69.2%25 identity in 224 aa overlap)%3B and Mb2587 in Mycobacterium bovis (224 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2557;product=Conserved protein;protein_id=CCP45353.1;transl_table=11
AL123456.3	EMBL	gene	2877831	2878541	.	+	.	ID=gene-Rv2558;Name=Rv2558;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2558
AL123456.3	EMBL	CDS	2877831	2878541	.	+	0	ID=cds-CCP45354.1;Parent=gene-Rv2558;Dbxref=EnsemblGenomes-Gn:Rv2558,EnsemblGenomes-Tr:CCP45354,GOA:P9WLA3,InterPro:IPR011008,NCBI_GP:CCP45354.1;Name=CCP45354.1;Note=Rv2558%2C (MTCY9C4.10c)%2C len: 236 aa. Conserved protein%2C highly similar to downstream ORF Q50741|MTCY9C4.11c|Rv2557|MT2645 conserved hypothetical protein from Mycobacterium tuberculosis (224 aa)%2C FASTA scores: opt: 1007%2C E(): 4.7e-59%2C (69.2%25 identity in 224 aa overlap)%3B and Mb2588 in Mycobacterium bovis (236 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2558;product=Conserved protein;protein_id=CCP45354.1;transl_table=11
AL123456.3	EMBL	gene	2878571	2879929	.	-	.	ID=gene-Rv2559c;Name=Rv2559c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2559c
AL123456.3	EMBL	CDS	2878571	2879929	.	-	0	ID=cds-CCP45355.1;Parent=gene-Rv2559c;Dbxref=EnsemblGenomes-Gn:Rv2559c,EnsemblGenomes-Tr:CCP45355,GOA:P9WQN1,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR008921,InterPro:IPR021886,InterPro:IPR027417,NCBI_GP:CCP45355.1;Name=CCP45355.1;Note=Rv2559c%2C (MTCY9C4.09)%2C len: 452 aa. Conserved hypothetical ala-%2C leu-%2C val-rich protein%2C equivalent to Q9CCT1|ML0510 hypothetical protein from Mycobacterium leprae (473 aa)%2C FASTA scores: opt: 2411%2C E(): 3.9e-121%2C(83.4%25 identity in 452 aa overlap)%3B O69490|O69490 hypothetical 47.1 KDA protein from Mycobacterium leprae (447 aa)%2C FASTA scores: opt: 2406%2C E(): 6.9e-121%2C (83.95%25 identity in 448 aa overlap). Also highly similar to Q9KXP4|SC9C5.30c conserved ATP/GTP binding protein from Streptomyces coelicolor (451 aa)%2C FASTA scores: opt: 1742%2CE(): 1.5e-85%2C (64.4%25 identity in 430 aa overlap)%3B Q9RT67|DR1898 conserved hypothetical protein from Deinococcus radiodurans (434 aa)%2C FASTA scores: opt: 1147%2CE(): 6.6e-54%2C (46.0%25 identity in 415 aa overlap)%3B P45262|YCAJ_HAEIN|HI1590 hypothetical protein from Haemophilus influenzae (446 aa)%2C FASTA scores: opt: 1140%2CE(): 1.6e-53%2C (42.5%25 identity in 428 aa overlap)%3B etc. Also similar to Q50629|MTCY227.09|RUVB|Rv2592c|MT2669|MTCY227.09 holliday junction DNA helicase from Mycobacterium tuberculosis (344 aa)%2C (30.1%25 identity in 296 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2559c;product=Conserved hypothetical alanine leucine valine rich protein;protein_id=CCP45355.1;transl_table=11
AL123456.3	EMBL	gene	2880075	2881052	.	+	.	ID=gene-Rv2560;Name=Rv2560;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2560
AL123456.3	EMBL	CDS	2880075	2881052	.	+	0	ID=cds-CCP45356.1;Parent=gene-Rv2560;Dbxref=EnsemblGenomes-Gn:Rv2560,EnsemblGenomes-Tr:CCP45356,GOA:P9WLA1,InterPro:IPR018692,NCBI_GP:CCP45356.1;Name=CCP45356.1;Note=Rv2560%2C (MTCY9C4.08c)%2C len: 325 aa. Probable transmembrane protein%2C pro-%2C gly-rich protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2560;product=Probable proline and glycine rich transmembrane protein;protein_id=CCP45356.1;transl_table=11
AL123456.3	EMBL	gene	2881252	2881320	.	+	.	ID=gene-mpr11;Name=mpr11;gbkey=Gene;gene=mpr11;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	2881252	2881320	.	+	.	ID=rna-mpr11;Parent=gene-mpr11;Note=mpr11%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C 82-100 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr11;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	2881252	2881320	.	+	.	ID=exon-mpr11-1;Parent=rna-mpr11;Note=mpr11%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C 82-100 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr11;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	2881409	2881702	.	+	.	ID=gene-Rv2561;Name=Rv2561;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2561
AL123456.3	EMBL	CDS	2881409	2881702	.	+	0	ID=cds-CCP45357.1;Parent=gene-Rv2561;Dbxref=EnsemblGenomes-Gn:Rv2561,EnsemblGenomes-Tr:CCP45357,InterPro:IPR020503,NCBI_GP:CCP45357.1;Name=CCP45357.1;Note=Rv2561%2C (MTCY9C4.07c)%2C len: 97 aa. Conserved hypothetical protein%2C highly similar in part (and longer 33 aa) to upstream ORF AAK46951|RV2562|MT2638|MTCY9C4.06c conserved hypothetical protein from Mycobacterium tuberculosis (212 aa)%2C FASTA scores: opt: 205%2C E(): 2e-06%2C(76.1%25 identity in 46 aa overlap).;gbkey=CDS;locus_tag=Rv2561;product=Conserved hypothetical protein;protein_id=CCP45357.1;transl_table=11
AL123456.3	EMBL	gene	2881758	2882147	.	+	.	ID=gene-Rv2562;Name=Rv2562;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2562
AL123456.3	EMBL	CDS	2881758	2882147	.	+	0	ID=cds-CCP45358.1;Parent=gene-Rv2562;Dbxref=EnsemblGenomes-Gn:Rv2562,EnsemblGenomes-Tr:CCP45358,InterPro:IPR020503,NCBI_GP:CCP45358.1;Name=CCP45358.1;Note=Rv2562%2C (MTCY9C4.06c)%2C len: 129 aa. Conserved hypothetical protein%2C highly similar%2C but shorter 83 aa%2C to downstream ORF AAK46951|RV2561|MT2638|MTCY9C4.07c conserved hypothetical protein from Mycobacterium tuberculosis (97 aa)%2C FASTA scores: opt: 866%2C E(): 2.2e-54%2C (100.0%25 identity in 129 aa overlap).;gbkey=CDS;locus_tag=Rv2562;product=Conserved hypothetical protein;protein_id=CCP45358.1;transl_table=11
AL123456.3	EMBL	gene	2882185	2882276	.	+	.	ID=gene-mpr12;Name=mpr12;gbkey=Gene;gene=mpr12;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	2882185	2882276	.	+	.	ID=rna-mpr12;Parent=gene-mpr12;Note=mpr12%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~118 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr12;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	2882185	2882276	.	+	.	ID=exon-mpr12-1;Parent=rna-mpr12;Note=mpr12%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C ~~118 nt band detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr12;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	2882290	2883339	.	+	.	ID=gene-Rv2563;Name=Rv2563;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2563
AL123456.3	EMBL	CDS	2882290	2883339	.	+	0	ID=cds-CCP45359.1;Parent=gene-Rv2563;Dbxref=EnsemblGenomes-Gn:Rv2563,EnsemblGenomes-Tr:CCP45359,GOA:P9WG15,InterPro:IPR003838,InterPro:IPR025857,NCBI_GP:CCP45359.1;Name=CCP45359.1;Note=Rv2563%2C (MTCY9C4.05c)%2C len: 349 aa. Probable glutamine-transport transmembrane protein ABC transporter (see citation below)%2C highly similar to O53617|Rv0072|MTV030.16 putative ABC-transporter transmembrane subunit from Mycobacterium tuberculosis (349 aa)%2C FASTA scores: opt: 1772%2C E(): 1.1e-89%2C (76.2%25 identity in 349 aa overlap). Also some similarity with various hypothetical proteins e.g. Q9RYN1|DRA0279 hypothetical 37.1 KDA protein from Deinococcus radiodurans (353 aa)%2C FASTA scores: opt: 347%2C E(): 6.6e-12%2C (24.35%25 identity in 357 aa overlap)%3B BAB58522|SAV2360 conserved hypothetical protein from Staphylococcus aureus subsp. aureus Mu50 (351 aa)%2CFASTA scores: opt: 262%2C E(): 2.9e-07%2C (19.4%25 identity in 356 aa overlap)%3B Q9AK94|SC10A9.10c putative ABC transport system transmembrane protein from Streptomyces coelicolor (379 aa)%2C FASTA scores: opt: 172%2C E(): 0.025%2C (26.85%25 identity in 387 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2563;product=Probable glutamine-transport transmembrane protein ABC transporter;protein_id=CCP45359.1;transl_table=11
AL123456.3	EMBL	gene	2883342	2884334	.	+	.	ID=gene-Rv2564;Name=glnQ;gbkey=Gene;gene=glnQ;gene_biotype=protein_coding;locus_tag=Rv2564
AL123456.3	EMBL	CDS	2883342	2884334	.	+	0	ID=cds-CCP45360.1;Parent=gene-Rv2564;Dbxref=EnsemblGenomes-Gn:Rv2564,EnsemblGenomes-Tr:CCP45360,GOA:P9WQI5,InterPro:IPR000595,InterPro:IPR002373,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR014710,InterPro:IPR017871,InterPro:IPR018488,InterPro:IPR018490,InterPro:IPR027417,NCBI_GP:CCP45360.1;Name=CCP45360.1;Note=Rv2564%2C (MTCY9C4.04c)%2C len: 330 aa. Probable glnQ%2Cglutamine-transport ATP-binding protein ABC transporter (see citation below)%2C highly similar to many e.g. Q9L0J9|SCD40A.12c putative ABC-transporter ATP-binding protein from Streptomyces coelicolor (246 aa)%2C FASTA scores: opt: 598%2C E(): 2.5e-26%2C (46.35%25 identity in 218 aa overlap)%3B O54136|SC2E9.11 from Streptomyces coelicolor (230 aa)%2C FASTA scores: opt: 592%2C E(): 5.1e-26%2C (46.55%25 identity in 219 aa overlap)%3B O29244|AF1018 from Archaeoglobus fulgidus (228 aa)%2C FASTA scores: opt: 580%2C E(): 2.4e-25%2C(42.4%25 identity in 210 aa overlap)%3B P75831|YBJZ_ECOLI|B0879 from Escherichia coli strain K12 (648 aa)%2C FASTA scores: opt: 555%2C E(): 1.3e-23%2C (39.65%25 identity in 232 aa overlap)%3B etc. Also highly similar to O53618|Rv0073|MTV030.17 ABC-transporter ATP-binding subunit from Mycobacterium tuberculosis (330 aa)%2C FASTA scores: opt: 1782%2C E(): 4.7e-92%2C (83.65%25 identity in 330 aa overlap)%3B etc. Shows some similarity to Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (612 aa) (32.9 %25 identity in 234 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2CPS00211 ABC transporters family signature%2C and PS00889 Cyclic nucleotide-binding domain signature 2. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnQ;inference=protein motif:PROSITE:PS00889;locus_tag=Rv2564;product=Probable glutamine-transport ATP-binding protein ABC transporter GlnQ;protein_id=CCP45360.1;transl_table=11
AL123456.3	EMBL	gene	2884611	2886362	.	+	.	ID=gene-Rv2565;Name=Rv2565;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2565
AL123456.3	EMBL	CDS	2884611	2886362	.	+	0	ID=cds-CCP45361.1;Parent=gene-Rv2565;Dbxref=EnsemblGenomes-Gn:Rv2565,EnsemblGenomes-Tr:CCP45361,GOA:P9WIY7,InterPro:IPR000595,InterPro:IPR001423,InterPro:IPR002641,InterPro:IPR014710,InterPro:IPR016035,InterPro:IPR018490,NCBI_GP:CCP45361.1;Name=CCP45361.1;Note=Rv2565%2C (MTCY9C4.03c)%2C len: 583 aa. Conserved protein%2C similar in part to Q9A6C3|CC2171 hypothetical protein from Caulobacter crescentus (610 aa)%2C FASTA scores: opt: 765%2C E(): 2.8e-37%2C (32.15%25 identity in 575 aa overlap). C-terminus also highly similar to various bacterial proteins e.g. O34731|YLBK_BACSU hypothetical 28.3 KDA protein from Bacillus subtilis (260 aa)%2C FASTA scores: opt: 386%2C E(): 2.2e-15%2C (33.05%25 identity in 245 aa overlap)%3B CAC45997|SMC01003 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (321 aa)%2CFASTA scores: opt: 352%2C E(): 2.5e-13%2C (29.65%25 identity in 280 aa overlap)%3B Q9K9Q8|BH2587 hypothetical protein from Bacillus halodurans (275 aa)%2C FASTA scores: opt: 334%2C E(): 2.5e-12%2C (33.7%25 identity in 175 aa overlap)%3B etc. And shows similarity to C-terminal half of some eukaryotic proteins e.g. Q9R114|NTE neuropathy target esterase homolog from Mus musculus (Mouse) (1327 aa)%2C FASTA scores: opt: 411%2C E(): 2.7e-16%2C (24.45%25 identity in 626 aa overlap)%3B O60859 neuropathy target esterase from Homo sapiens (Human) (1327 aa)%2C FASTA scores: opt: 410%2C E(): 3.1e-16%2C (24.1%25 identity in 627 aa overlap)%3B Q9U969|SWS|CG2212 swiss cheese protein from Drosophila melanogaster (Fruit fly) (1425 aa)%2C FASTA scores: opt: 401%2C E(): 1.1e-15%2C (27.75%25 identity in 544 aa overlap)%3B etc. Also shows strong similarity to C-terminal half of O05884|Z95121|Rv3239c|MTY20B11.14c hypothetical 110.2 KDA protein from Mycobacterium tuberculosis (1048 aa)%2C FASTA scores: opt: 648%2C E(): 3e-30%2C (36.55%25 identity in 572 aa overlap)%3B and O69695|Rv3728|MTV025.076 putative two-domain membrane protein from Mycobacterium tuberculosis (1065 aa)%2C FASTA scores: opt: 643%2C E(): 6e-30%2C (34.3%25 identity in 595 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2565;product=Conserved protein;protein_id=CCP45361.1;transl_table=11
AL123456.3	EMBL	gene	2886373	2889795	.	+	.	ID=gene-Rv2566;Name=Rv2566;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2566
AL123456.3	EMBL	CDS	2886373	2889795	.	+	0	ID=cds-CCP45362.1;Parent=gene-Rv2566;Dbxref=EnsemblGenomes-Gn:Rv2566,EnsemblGenomes-Tr:CCP45362,GOA:Q50732,InterPro:IPR002931,InterPro:IPR013589,InterPro:IPR018667,UniProtKB/TrEMBL:Q50732,NCBI_GP:CCP45362.1;Name=CCP45362.1;Note=Rv2566%2C (MTCY9C4.02c)%2C len: 1140 aa. Long conserved protein%2C equivalent to O53120|ML2678 or MLCB1913.12 hypothetical protein from Mycobacterium leprae (1000 aa)%2CFASTA scores: opt: 760%2C E(): 7.1e-38%2C (50.2%25 identity in 1128 aa overlap)%3B and middle part equivalent to Q9ZB40 72.2 KDA protein (fragment) from Mycobacterium leprae (644 aa)%2CFASTA scores: opt: 1017%2C E(): 1.5e-65%2C (45.65%25 identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (1119 aa)%2C FASTA scores: opt: 1413%2C E(): 3.7e-77%2C(52.4%25 identity in 1148 aa overlap)%3B and N-terminus shows similarity with other proteins e.g. Q9HUN8|PA4926 hypothetical protein from Pseudomonas aeruginosa (311 aa)%2CFASTA scores: opt: 278%2C E(): 3e-09%2C (29.95%25 identity in 284 aa overlap)%3B and upstream ORF Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 conserved hypothetical protein from Mycobacterium tuberculosis (314 aa)%2C FASTA scores: opt: 252%2C E(): 1.1e-07%2C (28.9%25 identity in 315 aa overlap). Equivalent to AAK46955 from Mycobacterium tuberculosis strain CDC1551 (1156 aa) but shorter 16 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2566;product=Long conserved protein;protein_id=CCP45362.1;transl_table=11
AL123456.3	EMBL	gene	2889795	2892449	.	+	.	ID=gene-Rv2567;Name=Rv2567;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2567
AL123456.3	EMBL	CDS	2889795	2892449	.	+	0	ID=cds-CCP45363.1;Parent=gene-Rv2567;Dbxref=EnsemblGenomes-Gn:Rv2567,EnsemblGenomes-Tr:CCP45363,GOA:P9WL97,InterPro:IPR007296,InterPro:IPR007302,NCBI_GP:CCP45363.1;Name=CCP45363.1;Note=Rv2567%2C (MTCY227.34c%2C MTCY9C4.01c)%2C len: 884 aa. Conserved hypothetical ala-%2C leu-rich protein%2C equivalent to O53121|ML2679|MLCB1913.13 hypothetical protein from Mycobacterium leprae (893 aa)%2C FASTA scores: opt: 4326%2CE(): 0%2C (75.2%25 identity in 883 aa overlap)%3B and similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 hypothetical 61.8 KDA protein from Mycobacterium leprae (561 aa)%2C FASTA scores: opt: 758%2C E(): 1.2e-38%2C (32.2%25 identity in 537 aa overlap). Also similar to others e.g. Q9HUN7|PA4927 hypothetical protein from Pseudomonas aeruginosa (830 aa)%2C FASTA scores: opt: 1247%2C E(): 2.2e-68%2C(38.25%25 identity in 831 aa overlap)%3B Q98HG7|MLL2876 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (803 aa)%2C FASTA scores: opt: 937%2C E(): 1.9e-49%2C(32.15%25 identity in 828 aa overlap)%3B CAC47419|SMC04057 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (802 aa)%2C FASTA scores: opt: 900%2CE(): 3.4e-47%2C (30.85%25 identity in 852 aa overlap)%3B etc. And similar to P71732|YO11_MYCTU|Rv2411c|MT2484|MTCY253.09 conserved hypothetical protein from Mycobacterium tuberculosis (551 aa)%2C FASTA scores: opt: 781%2C E(): 4.6e-40%2C (33.75%25 identity in 495 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2567;product=Conserved hypothetical alanine and leucine rich protein;protein_id=CCP45363.1;transl_table=11
AL123456.3	EMBL	gene	2892446	2893471	.	-	.	ID=gene-Rv2568c;Name=Rv2568c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2568c
AL123456.3	EMBL	CDS	2892446	2893471	.	-	0	ID=cds-CCP45364.1;Parent=gene-Rv2568c;Dbxref=EnsemblGenomes-Gn:Rv2568c,EnsemblGenomes-Tr:CCP45364,InterPro:IPR011201,NCBI_GP:CCP45364.1;Name=CCP45364.1;Note=Rv2568c%2C (MTCY227.33)%2C len: 341 aa. Conserved hypothetical protein%2C highly similar (but longer 60 aa) to Q98E75|MLR4376 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (308 aa)%2C FASTA scores: opt: 566%2C E(): 4.1e-29%2C (40.2%25 identity in 291 aa overlap).;gbkey=CDS;locus_tag=Rv2568c;product=Conserved hypothetical protein;protein_id=CCP45364.1;transl_table=11
AL123456.3	EMBL	gene	2893464	2894408	.	-	.	ID=gene-Rv2569c;Name=Rv2569c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2569c
AL123456.3	EMBL	CDS	2893464	2894408	.	-	0	ID=cds-CCP45365.1;Parent=gene-Rv2569c;Dbxref=EnsemblGenomes-Gn:Rv2569c,EnsemblGenomes-Tr:CCP45365,GOA:P9WL93,InterPro:IPR002931,InterPro:IPR013589,NCBI_GP:CCP45365.1;Name=CCP45365.1;Note=Rv2569c%2C (MTCY227.32)%2C len: 314 aa. Conserved hypothetical protein%2C equivalent to Q9CCT2|ML0508 hypothetical protein from Mycobacterium leprae (313 aa)%2CFASTA scores: opt: 1723%2C E(): 1.9e-95%2C (84.4%25 identity in 301 aa overlap)%3B and some similarity with Q49757|YP69_MYCLE|ML0607|MLCL536.03c|B1937_F2_39 hypothetical 31.1 KDA protein from Mycobacterium leprae (279 aa)%2C FASTA scores: opt: 305%2C E(): 4.5e-11%2C (33.0%25 identity in 300 aa overlap). Also similar to to other hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas aeruginosa (311 aa)%2C FASTA scores: opt: 704%2C E(): 8.7e-35%2C(39.7%25 identity in 320 aa overlap)%3B Q98HG8|MLL2875 from Rhizobium loti (Mesorhizobium loti) (294 aa)%2C FASTA scores: opt: 521%2C E(): 6.5e-24%2C (35.05%25 identity in 294 aa overlap)%3B Q9A7W9|CC1600 from Caulobacter crescentus (325 aa)%2C FASTA scores: opt: 510%2C E(): 3.2e-23%2C (34.4%25 identity in 2588 aa overlap)%3B etc. Also some similarity with proteins from Mycobacterium tuberculosis e.g. P71734|Rv2409c|MTCY253.11 conserved hypothetical protein (279 aa)%2C FASTA scores: opt: 312%2C E(): 1.7e-11%2C (34.45%25 identity in 296 aa overlap)%3B and Q50732|Rv2566|MTCY9C4.02 long conserved hypothetical protein (1140 aa)%2C FASTA scores: opt: 252%2C E(): 2.2e-07%2C (28.9%25 identity in 315 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2569c;product=Conserved hypothetical protein;protein_id=CCP45365.1;transl_table=11
AL123456.3	EMBL	gene	2894512	2894901	.	+	.	ID=gene-Rv2570;Name=Rv2570;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2570
AL123456.3	EMBL	CDS	2894512	2894901	.	+	0	ID=cds-CCP45366.1;Parent=gene-Rv2570;Dbxref=EnsemblGenomes-Gn:Rv2570,EnsemblGenomes-Tr:CCP45366,InterPro:IPR007351,NCBI_GP:CCP45366.1;Name=CCP45366.1;Note=Rv2570%2C (MTCY227.31c)%2C len: 129 aa. Conserved hypothetical protein%2C similar to Q98GQ7|MLR3218 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (133 aa)%2C FASTA scores: opt: 174%2C E(): 9.6e-05%2C(32.25%25 identity in 124 aa overlap)%3B Q9A390|CC3314 hypothetical protein from Caulobacter crescentus (129 aa)%2CFASTA scores: opt: 155%2C E(): 0.0017%2C (33.35%25 identity in 108 aa overlap)%3B and Q9A2Y0|CC3426 hypothetical protein from Caulobacter crescentus (120 aa)%2C FASTA scores: opt: 144%2C E(): 0.0083%2C (32.95%25 identity in 91 aa overlap).;gbkey=CDS;locus_tag=Rv2570;product=Conserved hypothetical protein;protein_id=CCP45366.1;transl_table=11
AL123456.3	EMBL	gene	2894893	2895960	.	-	.	ID=gene-Rv2571c;Name=Rv2571c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2571c
AL123456.3	EMBL	CDS	2894893	2895960	.	-	0	ID=cds-CCP45367.1;Parent=gene-Rv2571c;Dbxref=EnsemblGenomes-Gn:Rv2571c,EnsemblGenomes-Tr:CCP45367,GOA:P9WL89,NCBI_GP:CCP45367.1;Name=CCP45367.1;Note=Rv2571c%2C (MTCY227.30)%2C len: 355 aa. Probable transmembrane ala-%2C val-%2C leu-rich protein%2C showing some similarity with other membrane proteins e.g. Q99340|YFDA_CORGL hypothetical integral membrane protein from Corynebacterium glutamicum (Brevibacterium flavum) (359 aa)%2C FASTA scores: opt: 338%2C E(): 2.5e-13%2C (29.4%25 identity in 255 aa overlap)%3B Q9RD86|SCF43.02 putative integral membrane protein from Streptomyces coelicolor (379 aa)%2C FASTA scores: opt: 208%2C E(): 2.1e-05%2C (26.05%25 identity in 303 aa overlap)%3B Q9RD81|SCF43.07 putative integral membrane protein from Streptomyces coelicolor (419 aa)%2CFASTA scores: opt: 205%2C E(): 3.5e-05%2C (25.15%25 identity in 362 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2571c;product=Probable transmembrane alanine and valine and leucine rich protein;protein_id=CCP45367.1;transl_table=11
AL123456.3	EMBL	gene	2896013	2897803	.	-	.	ID=gene-Rv2572c;Name=aspS;gbkey=Gene;gene=aspS;gene_biotype=protein_coding;locus_tag=Rv2572c
AL123456.3	EMBL	CDS	2896013	2897803	.	-	0	ID=cds-CCP45368.1;Parent=gene-Rv2572c;Dbxref=EnsemblGenomes-Gn:Rv2572c,EnsemblGenomes-Tr:CCP45368,GOA:P9WFW3,InterPro:IPR002312,InterPro:IPR004115,InterPro:IPR004364,InterPro:IPR004365,InterPro:IPR004524,InterPro:IPR006195,InterPro:IPR012340,InterPro:IPR018150,InterPro:IPR029351,NCBI_GP:CCP45368.1;Name=CCP45368.1;Note=Rv2572c%2C (MTCY227.29)%2C len: 596 aa. Probable aspS%2Caspartyl-tRNA synthetase%2C equivalent to P36429|SYD_MYCLE|ML0501|MLCB1259.19 aspartyl-tRNA synthetase from Mycobacterium leprae (589 aa)%2C FASTA scores: opt: 3534%2C E(): 1.8e-215%2C (87.85%25 identity in 592 aa overlap). Also highly similar to many e.g. O67589|SYD_AQUAE|AQ_1677 from Aquifex aeolicus (603 aa)%2CFASTA scores: opt: 1829%2C E(): 8.2e-108%2C (47.5%25 identity in 598 aa overlap)%3B O32038|SYD_BACSU from Bacillus subtilis (592 aa)%2C FASTA scores: opt: 1732%2C E(): 1.1e-101%2C (46.25%25 identity in 597 aa overlap)%3B P21889|SYD_ECOLI|TLS|B1866 from Escherichia coli strain K12 (590 aa)%2C FASTA scores: opt: 1588%2C E(): 1.3e-92%2C (47.35%25 identity in 581 aa overlap)%3B etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aspS;inference=protein motif:PROSITE:PS00179;locus_tag=Rv2572c;product=Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase);protein_id=CCP45368.1;transl_table=11
AL123456.3	EMBL	gene	2898043	2898783	.	+	.	ID=gene-Rv2573;Name=Rv2573;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2573
AL123456.3	EMBL	CDS	2898043	2898783	.	+	0	ID=cds-CCP45369.1;Parent=gene-Rv2573;Dbxref=EnsemblGenomes-Gn:Rv2573,EnsemblGenomes-Tr:CCP45369,GOA:P9WIL1,InterPro:IPR003710,InterPro:IPR008927,InterPro:IPR013328,InterPro:IPR013332,InterPro:IPR013752,InterPro:IPR016040,PDB:4OL9,NCBI_GP:CCP45369.1;Name=CCP45369.1;Note=Rv2573%2C (MTCY227.28c)%2C len: 246 aa. Conserved hypothetical protein%2C similar to various proteins e.g. Q9ABG6|CC0261 hypothetical protein from Caulobacter crescentus (290 aa)%2C FASTA scores: opt: 516%2C E(): 5.8e-26%2C(40.1%25 identity in 237 aa overlap)%3B Q99R37|SA2393 hypothetical protein (similar to 2-dehydropantoate 2-reductase) from Staphylococcus aureus subsp. aureus N315 (286 aa)%2C FASTA scores: opt: 368%2C E(): 1.8e-16%2C (31.75%25 identity in 230 aa overlap)%3B Q9KPQ9|VC2307 2-dehydropantoate 2-reductase from Vibrio cholerae (296 aa)%2C FASTA scores: opt: 223%2C E(): 3.9e-07%2C (27.7%25 identity in 224 aa overlap)%3B etc. Equivalent to AAK46962 from Mycobacterium tuberculosis strain CDC1551 (275 aa) but shorter 29 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2573;product=Conserved hypothetical protein;protein_id=CCP45369.1;transl_table=11
AL123456.3	EMBL	gene	2898806	2899309	.	+	.	ID=gene-Rv2574;Name=Rv2574;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2574
AL123456.3	EMBL	CDS	2898806	2899309	.	+	0	ID=cds-CCP45370.1;Parent=gene-Rv2574;Dbxref=EnsemblGenomes-Gn:Rv2574,EnsemblGenomes-Tr:CCP45370,GOA:P9WL87,InterPro:IPR019587,InterPro:IPR023393,NCBI_GP:CCP45370.1;Name=CCP45370.1;Note=Rv2574%2C (MTCY227.27c)%2C len: 167 aa. Conserved protein%2C showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa)%2C FASTA scores: opt: 218%2C E(): 2.8e-08%2C (30.65%25 identity in 150 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2574;product=Conserved protein;protein_id=CCP45370.1;transl_table=11
AL123456.3	EMBL	gene	2899339	2900220	.	+	.	ID=gene-Rv2575;Name=Rv2575;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2575
AL123456.3	EMBL	CDS	2899339	2900220	.	+	0	ID=cds-CCP45371.1;Parent=gene-Rv2575;Dbxref=EnsemblGenomes-Gn:Rv2575,EnsemblGenomes-Tr:CCP45371,GOA:P9WL85,InterPro:IPR007343,NCBI_GP:CCP45371.1;Name=CCP45371.1;Note=Rv2575%2C (MTCY227.26c)%2C len: 293 aa. Possible conserved membrane gly-rich protein%2C highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiodurans (313 aa)%2CFASTA scores: opt: 734%2C E(): 2.8e-38%2C (42.95%25 identity in 291 aa overlap)%3B Q9HV81|PA4717 from Pseudomonas aeruginosa (297 aa)%2C FASTA scores: opt: 641%2C E(): 1.5e-32%2C (43.35%25 identity in 300 aa overlap)%3B Q98IA4|MLL2493 from Rhizobium loti (Mesorhizobium loti) (306 aa)%2C FASTA scores: opt: 628%2CE(): 1e-31%2C (38.45%25 identity in 307 aa overlap)%3B etc. Contains PS00142 Neutral zinc metallopeptidases%2Czinc-binding region signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv2575;product=Possible conserved membrane glycine rich protein;protein_id=CCP45371.1;transl_table=11
AL123456.3	EMBL	gene	2900226	2900690	.	-	.	ID=gene-Rv2576c;Name=Rv2576c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2576c
AL123456.3	EMBL	CDS	2900226	2900690	.	-	0	ID=cds-CCP45372.1;Parent=gene-Rv2576c;Dbxref=EnsemblGenomes-Gn:Rv2576c,EnsemblGenomes-Tr:CCP45372,GOA:P9WL83,InterPro:IPR016793,NCBI_GP:CCP45372.1;Name=CCP45372.1;Note=Rv2576c%2C (MTCY227.25)%2C len: 154 aa. Possible conserved membrane protein%2C showing similarity with Q9ZFC2 hypothetical 15.7 KDA protein from Mycobacterium sp. FM10 (146 aa)%2C FASTA scores: opt: 235%2C E(): 4.1e-08%2C (31.35%25 identity in 150 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2576c;product=Possible conserved membrane protein;protein_id=CCP45372.1;transl_table=11
AL123456.3	EMBL	gene	2900918	2902507	.	+	.	ID=gene-Rv2577;Name=Rv2577;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2577
AL123456.3	EMBL	CDS	2900918	2902507	.	+	0	ID=cds-CCP45373.1;Parent=gene-Rv2577;Dbxref=EnsemblGenomes-Gn:Rv2577,EnsemblGenomes-Tr:CCP45373,GOA:P9WL81,InterPro:IPR004843,InterPro:IPR006311,InterPro:IPR008963,InterPro:IPR015914,InterPro:IPR029052,NCBI_GP:CCP45373.1;Name=CCP45373.1;Note=Rv2577%2C (MTCY227.24c)%2C len: 529 aa. Conserved protein%2C showing similarity with various proteins from eukaryotes%2C in particular phosphatases%2C e.g. Q9SE01|pap purple acid phosphatase precursor from Glycine max (Soybean) (464 aa)%2C FASTA scores: opt: 190%2C E(): 0.00026%2C(27.3%25 identity in 388 aa overlap)%3B Q9SVP2|F18A5.90|AT4G13700 hypothetical 53.4 KDA protein from Arabidopsis thaliana (Mouse-ear cress) (474 aa)%2C FASTA scores: opt: 280%2C E(): 6.6e-10%2C (27.2%25 identity in 331 aa overlap)%3B Q9FK32 similarity to unknown protein from Arabidopsis thaliana (Mouse-ear cress) (529 aa)%2C FASTA scores: opt: 249%2C E(): 6.2e-08%2C (25.3%25 identity in 435 aa overlap)%3B Q12546|APHA acid phosphatase precursor from Aspergillus ficuum (614 aa)%2C FASTA scores: opt: 207%2C E(): 2.9e-05%2C (22.95%25 identity in 458 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2577;product=Conserved protein;protein_id=CCP45373.1;transl_table=11
AL123456.3	EMBL	gene	2902509	2903531	.	-	.	ID=gene-Rv2578c;Name=Rv2578c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2578c
AL123456.3	EMBL	CDS	2902509	2903531	.	-	0	ID=cds-CCP45374.1;Parent=gene-Rv2578c;Dbxref=EnsemblGenomes-Gn:Rv2578c,EnsemblGenomes-Tr:CCP45374,GOA:P9WL79,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR013785,NCBI_GP:CCP45374.1;Name=CCP45374.1;Note=Rv2578c%2C (MTCY227.23)%2C len: 340 aa. Conserved hypothetical protein%2C highly similar to hypothetical proteins (conserved or not) e.g. Q9ZBJ3|SC9C7.17c from Streptomyces coelicolor (348 aa)%2C FASTA scores: opt: 998%2CE(): 1.6e-55%2C (47.6%25 identity in 355 aa overlap)%3B Q9I763|PA0069 from Pseudomonas aeruginosa (352 aa)%2C FASTA scores: opt: 560%2C E(): 6e-28%2C (36.6%25 identity in 284 aa overlap)%3B Q986C9|MLL7417 from Rhizobium loti (Mesorhizobium loti) (356 aa)%2C FASTA scores: opt: 550%2C E(): 2.6e-27%2C(39.15%25 identity in 240 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2578c;product=Conserved hypothetical protein;protein_id=CCP45374.1;transl_table=11
AL123456.3	EMBL	gene	2903639	2904541	.	+	.	ID=gene-Rv2579;Name=dhaA;gbkey=Gene;gene=dhaA;gene_biotype=protein_coding;gene_synonym=linB;locus_tag=Rv2579
AL123456.3	EMBL	CDS	2903639	2904541	.	+	0	ID=cds-CCP45375.1;Parent=gene-Rv2579;Dbxref=EnsemblGenomes-Gn:Rv2579,EnsemblGenomes-Tr:CCP45375,GOA:P9WMR9,InterPro:IPR000639,InterPro:IPR023594,InterPro:IPR029058,PDB:2O2H,PDB:2O2I,PDB:2QVB,NCBI_GP:CCP45375.1;Name=CCP45375.1;Note=Rv2579%2C (MTCY227.22c)%2C len: 300 aa. Possible dhaA%2Chaloalkane dehalogenase%2C strictly equivalent to Q9XB14|ISO-RV2579 haloalkane dehalogenase (1-chlorohexane halidohydrolase) from Mycobacterium bovis (300 aa)%2C FASTA scores: opt: 2075%2C E(): 7.1e-125%2C (99.35%25 identity in 300 aa overlap)%3B note that only two residues%2C 120 and 293 are different. Also highly similar to others e.g. Q9ZER0|DHAAF haloalkane dehalogenase from Mycobacterium sp strain GP1 (307 aa)%2C FASTA scores: opt: 842%2C E(): 2.3e-46%2C (44.95%25 identity in 298 aa overlap)%3B Q53042|DHAA haloalkane dehalogenase from Rhodococcus rhodochrous%2C and Pseudomonas pavonaceae (293 aa)%2C FASTA scores: opt: 837%2C E(): 4.5e-46%2C(44.6%25 identity in 298 aa overlap)%3B etc. Note that this protein may also be a 1%2C3%2C4%2C6-tetrachloro-1%2C4-cyclohexadiene hydrolase%2C because also highly similar to P51698|LINB_PSEPA 1%2C3%2C4%2C6-tetrachloro-1%2C4-cyclohexadiene hydrolase from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (see Nagata et al.%2C 1993) (296 aa)%2C FASTA scores: opt: 1494%2CE(): 6.8e-88%2C (69.5%25 identity in 295 aa overlap). Also shows some similarity with proteins from Mycobacterium tuberculosis e.g. Q50670|YM96_MYCTU|Rv2296|MT2353|MTCY339.14c putative haloalkane dehalogenase (300 aa)%2C FASTA scores: opt: 302%2CE(): 5.3e-12%2C (30.85%25 identity in 295 aa overlap)%3B and Q50600|YJ33_MYCTU|Rv1833c|MT1881|MTCY1A11.10 hypothetical 32.2 KDA protein (286 aa)%2C FASTA scores: opt: 286%2C E(): 5.3e-11%2C (29.85%25 identity in 288 aa overlap). May belong to alpha/beta hydrolase fold family. Note that previously known as linB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dhaA;locus_tag=Rv2579;product=Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase);protein_id=CCP45375.1;transl_table=11
AL123456.3	EMBL	gene	2904821	2906092	.	-	.	ID=gene-Rv2580c;Name=hisS;gbkey=Gene;gene=hisS;gene_biotype=protein_coding;locus_tag=Rv2580c
AL123456.3	EMBL	CDS	2904821	2906092	.	-	0	ID=cds-CCP45376.1;Parent=gene-Rv2580c;Dbxref=EnsemblGenomes-Gn:Rv2580c,EnsemblGenomes-Tr:CCP45376,GOA:P9WFV5,InterPro:IPR004154,InterPro:IPR004516,InterPro:IPR006195,InterPro:IPR015807,NCBI_GP:CCP45376.1;Name=CCP45376.1;Note=Rv2580c%2C (MT2657%2C MTCY227.21)%2C len: 423 aa. Probable hisS%2C histidyl-tRNA synthetase%2C equivalent to P46696|SYH_MYCLE|hiss|ML0494|MLCB1259.12|B1177_C3_248 histidyl-tRNA synthetase from Mycobacterium leprae (427 aa)%2C FASTA scores: opt: 2380%2C E(): 2.1e-131%2C (85.85%25 identity in 417 aa overlap). Also highly similar to many e.g. Q9KXP2|hiss from Streptomyces coelicolor (425 aa)%2CFASTA scores: opt: 1542%2C E(): 1.4e-82%2C (56.0%25 identity in 418 aa overlap)%3B O32422|SYH_STAAU|hiss from Staphylococcus aureus (420 aa)%2C FASTA scores: opt: 1135%2C E(): 7.4e-59%2C(44.9%25 identity in 412 aa overlap)%3B P04804|SYH_ECOLI|hiss|B2514 from Escherichia coli strain K12 (423 aa)%2C FASTA scores: opt: 1099%2C E(): 9.4e-57%2C (43.9%25 identity in 417 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2580c;product=Probable histidyl-tRNA synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine--translase);protein_id=CCP45376.1;transl_table=11
AL123456.3	EMBL	gene	2906089	2906763	.	-	.	ID=gene-Rv2581c;Name=Rv2581c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2581c
AL123456.3	EMBL	CDS	2906089	2906763	.	-	0	ID=cds-CCP45377.1;Parent=gene-Rv2581c;Dbxref=EnsemblGenomes-Gn:Rv2581c,EnsemblGenomes-Tr:CCP45377,GOA:P9WMW3,InterPro:IPR001279,NCBI_GP:CCP45377.1;Name=CCP45377.1;Note=Rv2581c%2C (MTCY227.20)%2C len: 224 aa. Possible glyoxalase II%2C equivalent to Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247 hypothetical 23.9 KDA protein from Mycobacterium leprae (218 aa)%2C FASTA scores: opt: 1264%2C E(): 7.8e-73%2C (82.0%25 identity in 222 aa overlap). Also highly similar to Q9KXP1|SC9C5.33c possible hydrolase from Streptomyces coelicolor (235 aa)%2C FASTA scores: opt: 654%2C E(): 2.9e-34%2C(46.8%25 identity in 220 aa overlap)%3B and similar to Q9CI24|YFCI hypothetical protein from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (210 aa)%2C FASTA scores: opt: 360%2C E(): 9.9e-16%2C (35.0%25 identity in 217 aa overlap)%3B AAK75726|SP1646 metallo-beta-lactamase superfamily protein from Streptococcus pneumoniae (209 aa)%2CFASTA scores: opt: 320%2C E(): 3.3e-13%2C (35.85%25 identity in 198 aa overlap)%3B AAK80229|CAC2272 predicted Zn-dependent hydrolase of metallo-beta-lactamase superfamily from Clostridium acetobutylicum (199 aa)%2C FASTA scores: opt: 282%2C E(): 8e-11%2C (32.7%25 identity in 217 aa overlap)%3B etc. Equivalent to AAK46971 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 22 aa. Belongs to the glyoxalase II family. Cofactor: binds two zinc ions.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2581c;product=Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II);protein_id=CCP45377.1;transl_table=11
AL123456.3	EMBL	gene	2906814	2907740	.	+	.	ID=gene-Rv2582;Name=ppiB;gbkey=Gene;gene=ppiB;gene_biotype=protein_coding;gene_synonym=ppi;locus_tag=Rv2582
AL123456.3	EMBL	CDS	2906814	2907740	.	+	0	ID=cds-CCP45378.1;Parent=gene-Rv2582;Dbxref=EnsemblGenomes-Gn:Rv2582,EnsemblGenomes-Tr:CCP45378,GOA:P9WHW1,InterPro:IPR002130,InterPro:IPR029000,NCBI_GP:CCP45378.1;Name=CCP45378.1;Note=Rv2582%2C (MTCY227.19c)%2C len: 308 aa. Probable ppiB (alternate gene name: ppi)%2C cyclophilin (peptidyl-prolyl cis-trans isomerase)%2C equivalent to P46697|PPIB_MYCLE|PPI|ML0492|MLCB1259.10c|B1177_F3_97 probable peptidyl-prolyl cis-trans isomerase B from Mycobacterium leprae (295 aa)%2C FASTA scores: opt: 1423%2CE(): 1.3e-66%2C (72.2%25 identity in 295 aa overlap). Also similar to others e.g. Q9KJG8|PPIB peptidyl-prolyl cis-trans isomerase from Streptomyces lividans (277 aa)%2CFASTA scores: opt: 485%2C E(): 3.2e-18%2C (38.35%25 identity in 292 aa overlap)%3B Q9KXP0|SC9C5.34 peptidyl-prolyl cis-trans isomerase from Streptomyces coelicolor (277 aa)%2C FASTA scores: opt: 483%2C E(): 4.1e-18%2C (38.35%25 identity in 292 aa overlap)%3B Q9RT72|DR1893 peptidyl-prolyl cis-trans isomerase from Deinococcus radiodurans (350 aa)%2C FASTA scores: opt: 296%2C E(): 2.2e-08%2C (29.0%25 identity in 276 aa overlap)%3B etc. Belongs to the cyclophilin-type PPIase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppiB;locus_tag=Rv2582;product=Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase);protein_id=CCP45378.1;transl_table=11
AL123456.3	EMBL	gene	2907826	2910198	.	-	.	ID=gene-Rv2583c;Name=relA;gbkey=Gene;gene=relA;gene_biotype=protein_coding;locus_tag=Rv2583c
AL123456.3	EMBL	CDS	2907826	2910198	.	-	0	ID=cds-CCP45379.1;Parent=gene-Rv2583c;Dbxref=EnsemblGenomes-Gn:Rv2583c,EnsemblGenomes-Tr:CCP45379,GOA:P9WHG9,InterPro:IPR002912,InterPro:IPR003607,InterPro:IPR004095,InterPro:IPR004811,InterPro:IPR007685,InterPro:IPR012675,InterPro:IPR012676,NCBI_GP:CCP45379.1;Name=CCP45379.1;Note=Rv2583c%2C (MTCY227.18)%2C len: 790 aa. Probable relA%2CGTP pyrophosphokinase%2C equivalent to Q49640|RELA_MYCLE|ML0491|MLCB1259.09|B1177_C1_168 probable GTP pyrophosphokinase from Mycobacterium leprae (787 aa)%2CFASTA scores: opt: 4834%2C E(): 0%2C (93.4%25 identity in 790 aa overlap). Also highly similar to others e.g. O87331|RELA_CORGL|RELA|rel from Corynebacterium glutamicum (Brevibacterium flavum) (760 aa)%2C FASTA scores: opt: 3375%2CE(): 1.6e-196%2C (67.0%25 identity in 758 aa overlap)%3B O85709|RELA_STRAT from Streptomyces antibioticus (841 aa)%2CFASTA scores: opt: 3209%2C E(): 1.9e-186%2C (63.85%25 identity in 786 aa overlap)%3B Q9KDH1|RELA|BH1242 from Bacillus halodurans (728 aa)%2C FASTA scores: opt: 2195%2CE(): 3.8e-125%2C(45.65%25 identity in 714 aa overlap)%3B etc. Belongs to the RELA / spot family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=relA;locus_tag=Rv2583c;product=Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase);protein_id=CCP45379.1;transl_table=11
AL123456.3	EMBL	gene	2910229	2910900	.	-	.	ID=gene-Rv2584c;Name=apt;gbkey=Gene;gene=apt;gene_biotype=protein_coding;locus_tag=Rv2584c
AL123456.3	EMBL	CDS	2910229	2910900	.	-	0	ID=cds-CCP45380.1;Parent=gene-Rv2584c;Dbxref=EnsemblGenomes-Gn:Rv2584c,EnsemblGenomes-Tr:CCP45380,GOA:P9WQ07,InterPro:IPR000836,InterPro:IPR005764,InterPro:IPR029057,NCBI_GP:CCP45380.1;Name=CCP45380.1;Note=Rv2584c%2C (MTCY227.17)%2C len: 223 aa. Probable apt%2Cadenine phosphoribosyltransferase%2C similar%2C but longer in N-terminus%2C to others e.g. O87330|APT_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (185 aa)%2C FASTA scores: opt: 524%2C E(): 1.3e-24%2C (50.95%25 identity in 159 aa overlap)%3B P52561|APT_STRCO from Streptomyces coelicolor (182 aa)%2C FASTA scores: opt: 503%2C E(): 2.3e-23%2C(51.85%25 identity in 164 aa overlap)%3B P47956|APT_MUSPA|APRT from Mus pahari (Shrew mouse) (180 aa)%2C FASTA scores: opt: 419%2C E(): 2.5e-18%2C (44.7%25 identity in 170 aa overlap)%3B P07672|P09993|P77121|APT_ECOLI|B0469 from Escherichia coli strain K12 (183 aa)%2C FASTA scores: opt: 393%2C E(): 1.9e-18%2C(42.6%25 identity in 162 aa overlap)%3B etc. Contains PS00103 Purine/ pyrimidine phosphoribosyl transferases signature%2Cand PS00144 Asparaginase / glutaminase active site signature 1. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Nearest initiation codon indicated by homology is TTG at 17426 or GTG at 17465.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=apt;inference=protein motif:PROSITE:PS00144;locus_tag=Rv2584c;product=Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase);protein_id=CCP45380.1;transl_table=11
AL123456.3	EMBL	gene	2911004	2912677	.	-	.	ID=gene-Rv2585c;Name=Rv2585c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2585c
AL123456.3	EMBL	CDS	2911004	2912677	.	-	0	ID=cds-CCP45381.1;Parent=gene-Rv2585c;Dbxref=EnsemblGenomes-Gn:Rv2585c,EnsemblGenomes-Tr:CCP45381,GOA:P9WL77,InterPro:IPR000914,NCBI_GP:CCP45381.1;Name=CCP45381.1;Note=Rv2585c%2C (MT2662%2C MTCY227.16)%2C len: 557 aa. Possible conserved lipoprotein precursor%2C possibly attached to the membrane by a lipid anchor and substrate-binding protein involved in transport%2C equivalent to Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C2_197 hypothetical lipoprotein precursor from Mycobacterium leprae (555 aa)%2C FASTA scores: opt: 2812%2C E(): 9.8e-158%2C(78.95%25 identity in 546 aa overlap)%3B and C-terminus highly similar to C-terminus of Q49638|DCIAE|B1177_C1_166 DCIAE protein from Mycobacterium leprae (344 aa)%2C FASTA scores: opt: 1177%2C E(): 7.4e-62%2C (78.6%25 identity in 229 aa overlap). Also similar in part to various proteins%2Cprincipally substrate-binding proteins%2C e.g. O87329|DCIAE dipeptide-binding protein from Corynebacterium glutamicum (Brevibacterium flavum) (502 aa)%2C FASTA scores: opt: 614%2CE(): 1.2e-28%2C (30.7%25 identity in 427 aa overlap)%3B Q9AKR0|OPPA|CAC49261 putative oligopeptide uptake ABC transporter periplasmic solute-binding protein precursor from Rhizobium meliloti (Sinorhizobium meliloti) (532 aa)%2CFASTA scores: opt: 209%2C E(): 7.7e-05%2C (22.85%25 identity in 460 aa overlap)%3B P76128|YDDS_ECOLI|B1487|P77769|P76874 putative ABC transporter periplasmic binding protein from Escherichia coli strain K12 (516 aa)%2C FASTA scores: opt: 182%2C E(): 0.0029%2C (20.0%25 identity in 315 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2585c;product=Possible conserved lipoprotein;protein_id=CCP45381.1;transl_table=11
AL123456.3	EMBL	gene	2912683	2914011	.	-	.	ID=gene-Rv2586c;Name=secF;gbkey=Gene;gene=secF;gene_biotype=protein_coding;locus_tag=Rv2586c
AL123456.3	EMBL	CDS	2912683	2914011	.	-	0	ID=cds-CCP45382.1;Parent=gene-Rv2586c;Dbxref=EnsemblGenomes-Gn:Rv2586c,EnsemblGenomes-Tr:CCP45382,GOA:P9WGN9,InterPro:IPR005665,InterPro:IPR022645,InterPro:IPR022646,InterPro:IPR022813,NCBI_GP:CCP45382.1;Name=CCP45382.1;Note=Rv2586c%2C (MT2663%2C MTCY227.15)%2C len: 442 aa. Probable secF%2C protein-export membrane protein (integral membrane protein) (see citation below)%2C equivalent to P38386|SECF_MYCLE|SECF|ML0488|MLCB1259.06|B1177_C3_239 protein-export membrane protein from Mycobacterium leprae (471 aa)%2C FASTA scores: opt: 1910%2C E(): 2.9e-104%2C (72.15%25 identity in 456 aa overlap). Also similar to others e.g. Q9AE06|SECF from Corynebacterium glutamicum (Brevibacterium flavum) (403 aa)%2C FASTA scores: opt: 1198%2C E(): 9.8e-63%2C(47.1%25 identity in 399 aa overlap)%3B Q53956|SECF_STRCO|SCL2.05c from Streptomyces coelicolor (373 aa)%2C FASTA scores: opt: 670%2C E(): 6.4e-32%2C (39.25%25 identity in 400 aa overlap)%3B Q55611|SECF_SYNY3|SLR0775 from Synechocystis sp. strain PCC 6803 (315 aa)%2C FASTA scores: opt: 416%2C E(): 3.8e-17%2C (33.8%25 identity in 296 aa overlap)%3B etc. Belongs to the SECD/SECF family%2C SECF family. Part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c%2C SECD|Rv2587c%2C SECE|Rv0638%2C SECF%2CSECG|Rv1440 and SECY|Rv0732.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=secF;locus_tag=Rv2586c;product=Probable protein-export membrane protein SecF;protein_id=CCP45382.1;transl_table=11
AL123456.3	EMBL	gene	2914015	2915736	.	-	.	ID=gene-Rv2587c;Name=secD;gbkey=Gene;gene=secD;gene_biotype=protein_coding;locus_tag=Rv2587c
AL123456.3	EMBL	CDS	2914015	2915736	.	-	0	ID=cds-CCP45383.1;Parent=gene-Rv2587c;Dbxref=EnsemblGenomes-Gn:Rv2587c,EnsemblGenomes-Tr:CCP45383,GOA:P9WGP1,InterPro:IPR005791,InterPro:IPR022645,InterPro:IPR022646,InterPro:IPR022813,NCBI_GP:CCP45383.1;Name=CCP45383.1;Note=Rv2587c%2C (MTCY227.14)%2C len: 573 aa. Probable secD%2Cprotein-export membrane protein (integral membrane protein) (see citation below)%2C equivalent to P38387|SECD_MYCLE|ML0487|MLCB1259.05|B1177_C1_164 protein-export membrane protein from Mycobacterium leprae (571 aa)%2C FASTA scores: opt: 2948%2C E(): 2.6e-97%2C (80.6%25 identity in 583 aa overlap). Also similar to others e.g. Q9AE07|SECD from Corynebacterium glutamicum (Brevibacterium flavum) (637 aa)%2C FASTA scores: opt: 1023%2C E(): 1.9e-29%2C(44.95%25 identity in 596 aa overlap)%3B Q53955|SECD_STRCO from Streptomyces coelicolor (570 aa)%2C FASTA scores: opt: 864%2CE(): 7.2e-24%2C (38.0%25 identity in 584 aa overlap)%3B O33517|SECD_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (554 aa)%2C FASTA scores: opt: 551%2C E(): 7.6e-13%2C (32.25%25 identity in 304 aa overlap)%3B etc. Equivalent to AAK46977 from Mycobacterium tuberculosis strain CDC1551 (554 aa) but longer 19 aa. Belongs to the SecD/SecF family%2C SecD family. Part of the prokaryotic protein translocation apparatus which comprise SECA|Rv3240c%2C SECD%2C SECE|Rv0638%2C SECF|Rv2586c%2C SECG|Rv1440 and SECY|Rv0732.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=secD;locus_tag=Rv2587c;product=Probable protein-export membrane protein SecD;protein_id=CCP45383.1;transl_table=11
AL123456.3	EMBL	gene	2915846	2916193	.	-	.	ID=gene-Rv2588c;Name=yajC;gbkey=Gene;gene=yajC;gene_biotype=protein_coding;locus_tag=Rv2588c
AL123456.3	EMBL	CDS	2915846	2916193	.	-	0	ID=cds-CCP45384.1;Parent=gene-Rv2588c;Dbxref=EnsemblGenomes-Gn:Rv2588c,EnsemblGenomes-Tr:CCP45384,GOA:P9WL75,InterPro:IPR003849,NCBI_GP:CCP45384.1;Name=CCP45384.1;Note=Rv2588c%2C (MTCY227.13)%2C len: 115 aa. Probable yajC%2Csecretion factor%2C a conserved membrane protein (see Braunstein %26 Belisle 2000)%2C equivalent to Q49647|YP88_MYCLE|ML0486|MLCB1259.04|B1177_C3_235 hypothetical 12.8 KDA protein from Mycobacterium leprae (114 aa)%2C FASTA scores: opt: 499%2C E(): 2.7e-26%2C (77.0%25 identity in 100 aa overlap). Also similar to other proteins e.g. Q9AE08 hypothetical 13.5 KDA protein from Corynebacterium glutamicum (Brevibacterium flavum) (121 aa)%2C FASTA scores: opt: 222%2C E(): 5e-08%2C (39.8%25 identity in 103 aa overlap)%3B Q9L292|SCL2.07c putative secreted protein from Streptomyces coelicolor (169 aa)%2C FASTA scores: opt: 203%2C E(): 1.2e-06%2C (32.05%25 identity in 106 aa overlap)%3B Q9CDT0|YWAB unknown protein from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (110 aa)%2C FASTA scores: opt: 150%2C E(): 0.0026%2C (30.85%25 identity in 94 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yajC;locus_tag=Rv2588c;product=Probable conserved membrane protein secretion factor YajC;protein_id=CCP45384.1;transl_table=11
AL123456.3	EMBL	gene	2916360	2917709	.	+	.	ID=gene-Rv2589;Name=gabT;gbkey=Gene;gene=gabT;gene_biotype=protein_coding;locus_tag=Rv2589
AL123456.3	EMBL	CDS	2916360	2917709	.	+	0	ID=cds-CCP45385.1;Parent=gene-Rv2589;Dbxref=EnsemblGenomes-Gn:Rv2589,EnsemblGenomes-Tr:CCP45385,GOA:P9WQ79,InterPro:IPR004632,InterPro:IPR005814,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP45385.1;Name=CCP45385.1;Note=Rv2589%2C (MTCY227.12c)%2C len: 449 aa. Probable gabT%2C4-aminobutyrate aminotransferase%2C equivalent to P40829|GABT_MYCLE|ML0485|MLCB1259.03c|B1177_F2_67 4-aminobutyrate aminotransferase (446 aa)%2C FASTA scores: opt: 2468%2C E(): 4.5e-141%2C (83.75%25 identity in 449 aa overlap). Also highly similar to others e.g. O86823|GABT from Streptomyces coelicolor (444 aa)%2C FASTA scores: opt: 1832%2C E(): 8e-103%2C (63.9%25 identity in 443 aa overlap)%3B AAK79395|CAC1427 from Clostridium acetobutylicum (445 aa)%2CFASTA scores: opt: 1283%2C E(): 8.4e-70%2C (45.75%25 identity in 433 aa overlap)%3B Q9KE66|BH0991 from Bacillus halodurans (443 aa)%2C FASTA scores: opt: 1224%2C E(): 2.9e-66%2C (44.55%25 identity in 431 aa overlap)%3B etc. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gabT;inference=protein motif:PROSITE:PS00600;locus_tag=Rv2589;product=4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at);protein_id=CCP45385.1;transl_table=11
AL123456.3	EMBL	gene	2917871	2921377	.	+	.	ID=gene-Rv2590;Name=fadD9;gbkey=Gene;gene=fadD9;gene_biotype=protein_coding;locus_tag=Rv2590
AL123456.3	EMBL	CDS	2917871	2921377	.	+	0	ID=cds-CCP45386.1;Parent=gene-Rv2590;Dbxref=EnsemblGenomes-Gn:Rv2590,EnsemblGenomes-Tr:CCP45386,GOA:Q50631,InterPro:IPR000873,InterPro:IPR009081,InterPro:IPR010080,InterPro:IPR013120,InterPro:IPR016040,InterPro:IPR020845,UniProtKB/TrEMBL:Q50631,NCBI_GP:CCP45386.1;Name=CCP45386.1;Note=Rv2590%2C (MTCY227.11c)%2C len: 1168 aa. Probable fadD9%2Cfatty-acid-CoA synthetase%2C highly similar to O69484|FADD9 (alias Q9CCT4|FADD9|ML0484 but longer 14 aa) putative acyl-CoA synthetase from Mycobacterium leprae (1174 aa)%2CFASTA scores: opt: 5247%2C E(): 0%2C (68.0%25 identity in 1178 aa overlap). N-terminal (approximately 700 residues) similar to other long chain fatty acid ligases. And C-terminus highly similar to C-terminus of Q9XCF2|PSTB PSTB protein from Mycobacterium avium (2552 aa)%2C FASTA scores: opt: 2083%2C E(): 8.4e-116%2C (40.8%25 identity in 1150 aa overlap) (and weak similarity on N-terminus). C-terminal part highly similar to polyketide synthases and peptides synthases (weak similarity on N-terminus) e.g. Q10896|Rv0101|MTCY251.20|NRP probable peptide synthetase from Mycobacterium tuberculosis (2512 aa)%2C FASTA scores: opt: 1988%2C E(): 3.7e-110%2C (40.2%25 identity in 1181 aa overlap)%3B etc. Contains PS00455 putative AMP-binding domain signature%2C and PS00061 Short-chain alcohol dehydrogenase family signature. Seems to belong to the ATP-dependent AMP-binding enzyme family%2C and to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD9;inference=protein motif:PROSITE:PS00455;locus_tag=Rv2590;product=Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP45386.1;transl_table=11
AL123456.3	EMBL	gene	2921551	2923182	.	+	.	ID=gene-Rv2591;Name=PE_PGRS44;gbkey=Gene;gene=PE_PGRS44;gene_biotype=protein_coding;locus_tag=Rv2591
AL123456.3	EMBL	CDS	2921551	2923182	.	+	0	ID=cds-CCP45387.1;Parent=gene-Rv2591;Dbxref=EnsemblGenomes-Gn:Rv2591,EnsemblGenomes-Tr:CCP45387,InterPro:IPR000084,NCBI_GP:CCP45387.1;Name=CCP45387.1;Note=Rv2591%2C (MTCY227.10c)%2C len: 543 aa. PE_PGRS44%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to others e.g. O53845|Rv0834c|MTV043.26c from Mycobacterium tuberculosis (882 aa)%2C FASTA scores: opt: 1813%2C E(): 5.8e-66%2C (55.3%25 identity in 568 aa overlap). Equivalent to AAK46982 from Mycobacterium tuberculosis strain CDC1551 (505 aa) but longer 38 aa. Contains PS00583 pfkB family of carbohydrate kinases signature 1.;gbkey=CDS;gene=PE_PGRS44;inference=protein motif:PROSITE:PS00583;locus_tag=Rv2591;product=PE-PGRS family protein PE_PGRS44;protein_id=CCP45387.1;transl_table=11
AL123456.3	EMBL	gene	2923199	2924233	.	-	.	ID=gene-Rv2592c;Name=ruvB;gbkey=Gene;gene=ruvB;gene_biotype=protein_coding;locus_tag=Rv2592c
AL123456.3	EMBL	CDS	2923199	2924233	.	-	0	ID=cds-CCP45388.1;Parent=gene-Rv2592c;Dbxref=EnsemblGenomes-Gn:Rv2592c,EnsemblGenomes-Tr:CCP45388,GOA:P9WGW1,InterPro:IPR003593,InterPro:IPR004605,InterPro:IPR008823,InterPro:IPR008824,InterPro:IPR011991,InterPro:IPR027417,NCBI_GP:CCP45388.1;Name=CCP45388.1;Note=Rv2592c%2C (MTCY227.09)%2C len: 344 aa. Probable ruvB%2CHolliday junction binding protein (see Mizrahi %26 Andersen 1998)%2C equivalent to P40833|RUVB_MYCLE|ML0483|B1177_C3_227 holliday junction DNA helicase from Mycobacterium leprae (349 aa)%2C FASTA scores: opt: 2059%2C E(): 2.1e-106%2C (94.45%25 identity in 342 aa overlap). Also highly similar to others e.g. Q9AE09|RUVB from Corynebacterium glutamicum (Brevibacterium flavum) (363 aa)%2C FASTA scores: opt: 1651%2CE(): 6.5e-84%2C (75.6%25 identity in 332 aa overlap)%3B Q9L291|RUVB from Streptomyces coelicolor (357 aa)%2C FASTA scores: opt: 1530%2C E(): 3e-77%2C (68.2%25 identity in 343 aa overlap)%3B P08577|RUVB_ECOLI|B1860|Z2912|ECS2570 from Escherichia coli strains K12 and O157:H7 (336 aa)%2C FASTA scores: opt: 1284%2C E(): 1e-63%2C (55.45%25 identity in 330 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the RuvB family.;gbkey=CDS;gene=ruvB;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2592c;product=Probable holliday junction DNA helicase RuvB;protein_id=CCP45388.1;transl_table=11
AL123456.3	EMBL	gene	2924230	2924820	.	-	.	ID=gene-Rv2593c;Name=ruvA;gbkey=Gene;gene=ruvA;gene_biotype=protein_coding;locus_tag=Rv2593c
AL123456.3	EMBL	CDS	2924230	2924820	.	-	0	ID=cds-CCP45389.1;Parent=gene-Rv2593c;Dbxref=EnsemblGenomes-Gn:Rv2593c,EnsemblGenomes-Tr:CCP45389,GOA:P9WGW3,InterPro:IPR000085,InterPro:IPR003583,InterPro:IPR010994,InterPro:IPR011114,InterPro:IPR012340,InterPro:IPR013849,PDB:2H5X,PDB:2ZTC,PDB:2ZTD,PDB:2ZTE,NCBI_GP:CCP45389.1;Name=CCP45389.1;Note=Rv2593c%2C (MTCY227.08)%2C len: 196 aa. Probable ruvA%2CHolliday junction binding protein (see citations below)%2Cequivalent to P40832|RUVA_MYCLE|ML0482|B1177_C2_188 holliday junction DNA helicase from Mycobacterium leprae (203 aa)%2C FASTA scores: opt: 923%2C E(): 9.9e-50%2C (76.85%25 identity in 203 aa overlap). Also highly similar to others e.g. Q9L290|RUVA from Streptomyces coelicolor (201 aa) (201 aa)%2C FASTA scores: opt: 549%2C E(): 8.2e-27%2C (47.55%25 identity in 204 aa overlap)%3B Q9AE10|RUVA from Corynebacterium glutamicum (Brevibacterium flavum) (206 aa)%2C FASTA scores: opt: 440%2C E(): 4e-20%2C (47.1%25 identity in 206 aa overlap)%3B P08576|RUVA_ECOLI|B1861|Z2913|ECS2571 from Escherichia coli strains K12 and O157:H7 (203 aa)%2C FASTA scores: opt: 312%2CE(): 2.8e-12%2C (34.85%25 identity in 201 aa overlap)%3B etc. Belongs to the RuvA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ruvA;locus_tag=Rv2593c;product=Probable holliday junction DNA helicase RuvA;protein_id=CCP45389.1;transl_table=11
AL123456.3	EMBL	gene	2924817	2925383	.	-	.	ID=gene-Rv2594c;Name=ruvC;gbkey=Gene;gene=ruvC;gene_biotype=protein_coding;locus_tag=Rv2594c
AL123456.3	EMBL	CDS	2924817	2925383	.	-	0	ID=cds-CCP45390.1;Parent=gene-Rv2594c;Dbxref=EnsemblGenomes-Gn:Rv2594c,EnsemblGenomes-Tr:CCP45390,GOA:P9WGV9,InterPro:IPR002176,InterPro:IPR012337,InterPro:IPR020563,NCBI_GP:CCP45390.1;Name=CCP45390.1;Note=Rv2594c%2C (MTCY227.07)%2C len: 188 aa. Probable ruvC%2CHolliday junction resolvase (see citations below)%2Cequivalent to P40834|RUVC_MYCLE|ML0481|B1177_C3_226 crossover junction endodeoxyribonuclease from Mycobacterium leprae (188 aa)%2C FASTA scores: opt: 984%2C E(): 2.3e-55%2C(81.0%25 identity in 184 aa overlap). Also highly similar to others e.g. Q9AE11|RUVC from Corynebacterium glutamicum (Brevibacterium flavum) (221 aa)%2C FASTA scores: opt: 713%2CE(): 3.6e-38%2C (56.9%25 identity in 188 aa overlap)%3B Q9L289|RUVC_STRCO|SCL2.10c from Streptomyces coelicolor (188 aa)%2C FASTA scores: opt: 704%2C E(): 1.2e-37%2C (60.65%25 identity in 178 aa overlap)%3B P24239|RUVC_ECOLI|B1863 from Escherichia coli strain K12 (172 aa)%2C FASTA scores: opt: 322%2C E(): 1.6e-13%2C (38.65%25 identity in 163 aa overlap)%3B etc. Belongs to the RUVC family. Cofactor: magnesium.;gbkey=CDS;gene=ruvC;locus_tag=Rv2594c;product=Probable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase);protein_id=CCP45390.1;transl_table=11
AL123456.3	EMBL	gene	2925492	2925737	.	+	.	ID=gene-Rv2595;Name=vapB40;gbkey=Gene;gene=vapB40;gene_biotype=protein_coding;locus_tag=Rv2595
AL123456.3	EMBL	CDS	2925492	2925737	.	+	0	ID=cds-CCP45391.1;Parent=gene-Rv2595;Dbxref=EnsemblGenomes-Gn:Rv2595,EnsemblGenomes-Tr:CCP45391,GOA:P9WFC3,InterPro:IPR007159,NCBI_GP:CCP45391.1;Name=CCP45391.1;Note=Rv2595%2C (MTCY227.06c)%2C len: 81 aa. Possible vapB40%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2596%2Csee Arcus et al. 2005. Similarity with various bacterial proteins e.g. O28268|AF2011 conserved hypothetical protein from Archaeoglobus fulgidus (86 aa)%2C FASTA scores: opt: 120%2C E(): 0.13%2C (34.35%25 identity in 67 aa overlap)%3B CAC46196|SMC01176 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (79 aa)%2C FASTA scores: opt: 119%2C E(): 0.14%2C (33.35%25 identity in 63 aa overlap)%3B P37554|SP5T_BACSU|SPOVT stage V sporulation protein T from Bacillus subtilis (178 aa)%2C FASTA scores: opt: 104%2C E(): 2.9%2C (51.45%25 identity in 35 aa overlap)%3B etc. Also similar to O07779|Rv0599c|MTCY19H5.23 hypothetical protein from Mycobacterium tuberculosis (78 aa)%2C FASTA scores: opt: 160%2C E(): 0.00026%2C (35.8%25 identity in 81 aa overlap).;gbkey=CDS;gene=vapB40;locus_tag=Rv2595;product=Possible antitoxin VapB40;protein_id=CCP45391.1;transl_table=11
AL123456.3	EMBL	gene	2925734	2926138	.	+	.	ID=gene-Rv2596;Name=vapC40;gbkey=Gene;gene=vapC40;gene_biotype=protein_coding;locus_tag=Rv2596
AL123456.3	EMBL	CDS	2925734	2926138	.	+	0	ID=cds-CCP45392.1;Parent=gene-Rv2596;Dbxref=EnsemblGenomes-Gn:Rv2596,EnsemblGenomes-Tr:CCP45392,GOA:P9WF61,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45392.1;Name=CCP45392.1;Note=Rv2596%2C (MTCY227.05c)%2C len: 134 aa. Possible vapC40%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2595%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. O07780|Rv0598c|MTCY19H5.24 hypothetical 14.8 KDA protein from (137 aa)%2C FASTA scores: opt: 254%2C E(): 8.8e-11%2C(41.55%25 identity in 130 aa overlap).;gbkey=CDS;gene=vapC40;locus_tag=Rv2596;product=Possible toxin VapC40. Contains PIN domain.;protein_id=CCP45392.1;transl_table=11
AL123456.3	EMBL	gene	2926355	2926975	.	+	.	ID=gene-Rv2597;Name=Rv2597;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2597
AL123456.3	EMBL	CDS	2926355	2926975	.	+	0	ID=cds-CCP45393.1;Parent=gene-Rv2597;Dbxref=EnsemblGenomes-Gn:Rv2597,EnsemblGenomes-Tr:CCP45393,GOA:P9WL73,InterPro:IPR025235,NCBI_GP:CCP45393.1;Name=CCP45393.1;Note=Rv2597%2C (MTCY227.04c)%2C len: 206 aa. Probable membrane protein. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2597;product=Probable membrane protein;protein_id=CCP45393.1;transl_table=11
AL123456.3	EMBL	gene	2926986	2927480	.	+	.	ID=gene-Rv2598;Name=Rv2598;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2598
AL123456.3	EMBL	CDS	2926986	2927480	.	+	0	ID=cds-CCP45394.1;Parent=gene-Rv2598;Dbxref=EnsemblGenomes-Gn:Rv2598,EnsemblGenomes-Tr:CCP45394,InterPro:IPR024486,NCBI_GP:CCP45394.1;Name=CCP45394.1;Note=Rv2598%2C (MTCY227.03c)%2C len: 164 aa. Conserved hypothetical protein%2C showing similarity with hypothetical proteins from Streptomyces coelicolor e.g. Q9X8S3|SCH10.34c (185 aa)%2C FASTA scores: opt: 197%2C E(): 3.5e-06%2C (34.75%25 identity in 167 aa overlap)%3B and Q9L088|SCC24.29c (172 aa)%2CFASTA scores: opt: 149%2C E(): 0.0053%2C (37.65%25 identity in 146 aa overlap). Equivalent to AAK46988 from Mycobacterium tuberculosis strain CDC1551 (154 aa) but longer 10 aa.;gbkey=CDS;locus_tag=Rv2598;product=Conserved hypothetical protein;protein_id=CCP45394.1;transl_table=11
AL123456.3	EMBL	gene	2927477	2927908	.	+	.	ID=gene-Rv2599;Name=Rv2599;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2599
AL123456.3	EMBL	CDS	2927477	2927908	.	+	0	ID=cds-CCP45395.1;Parent=gene-Rv2599;Dbxref=EnsemblGenomes-Gn:Rv2599,EnsemblGenomes-Tr:CCP45395,GOA:P9WL69,InterPro:IPR025341,NCBI_GP:CCP45395.1;Name=CCP45395.1;Note=Rv2599%2C (MTCY227.02c)%2C len: 143 aa. Probable conserved membrane protein%2C equivalent to Q9K536|2599 hypothetical 15.0 KDA protein (fragment) from Mycobacterium paratuberculosis (143 aa)%2C FASTA scores: opt: 691%2C E(): 1.7e-33%2C (68.55%25 identity in 143 aa overlap). Shows weak similarity with Q9L089|SCC24.28c putative lipoprotein from Streptomyces coelicolor (131 aa)%2C FASTA scores: opt: 130%2CE(): 0.52%2C (26.45%25 identity in 136 aa overlap). Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00626;locus_tag=Rv2599;product=Probable conserved membrane protein;protein_id=CCP45395.1;transl_table=11
AL123456.3	EMBL	gene	2927990	2928391	.	+	.	ID=gene-Rv2600;Name=Rv2600;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2600
AL123456.3	EMBL	CDS	2927990	2928391	.	+	0	ID=cds-CCP45396.1;Parent=gene-Rv2600;Dbxref=EnsemblGenomes-Gn:Rv2600,EnsemblGenomes-Tr:CCP45396,GOA:P9WFG5,InterPro:IPR007140,NCBI_GP:CCP45396.1;Name=CCP45396.1;Note=Rv2600%2C (MTCY277.01c%2C MTV001.01)%2C len: 133 aa. Probable conserved integral membrane protein%2C equivalent (but shorter 18 aa) to Q9K537|YQ00_MYCPA hypothetical protein RV2600 homolog from Mycobacterium paratuberculosis (151 aa)%2C FASTA scores: opt: 543%2C E(): 4.2e-28%2C (62.9%25 identity in 132 aa overlap). Also some similarity with other hypothetical or membrane proteins e.g. Q9L090|SCC24.27c putative integral membrane protein from Streptomyces coelicolor (146 aa)%2C FASTA scores: opt: 241%2CE(): 8.7e-09%2C (34.8%25 identity in 135 aa overlap)%3B O58487|PH0773 hypothetical 15.0 KDA protein from Pyrococcus horikoshii (138 aa)%2C FASTA scores: opt: 116%2C E(): 0.84%2C(34.35%25 identity in 96 aa overlap)%3B etc. Equivalent to AAK46990 from Mycobacterium tuberculosis strain CDC1551 (152 aa) but shorter 19 aa.;gbkey=CDS;locus_tag=Rv2600;product=Probable conserved integral membrane protein;protein_id=CCP45396.1;transl_table=11
AL123456.3	EMBL	gene	2928388	2929959	.	+	.	ID=gene-Rv2601;Name=speE;gbkey=Gene;gene=speE;gene_biotype=protein_coding;locus_tag=Rv2601
AL123456.3	EMBL	CDS	2928388	2929959	.	+	0	ID=cds-CCP45397.1;Parent=gene-Rv2601;Dbxref=EnsemblGenomes-Gn:Rv2601,EnsemblGenomes-Tr:CCP45397,GOA:P9WGE5,InterPro:IPR001045,InterPro:IPR029063,NCBI_GP:CCP45397.1;Name=CCP45397.1;Note=Rv2601%2C (MTCI270.04c-MTV001.02)%2C len: 523 aa. Probable speE%2C spermidine synthase%2C highly similar to many e.g. Q9L091|SCC24.26c from Streptomyces coelicolor (531 aa)%2C FASTA scores: opt: 1493%2C E(): 1.3e-79%2C (48.45%25 identity in 514 aa overlap)%3B Q9X8S2|SCH10.33c from Streptomyces coelicolor (554 aa)%2C FASTA scores: opt: 1045%2CE(): 1.7e-53%2C (40.55%25 identity in 525 aa overlap)%3B P09158|SPEE_ECOLI|B0121 from Escherichia coli strain K12 (287 aa)%2C FASTA scores: opt: 368%2C E(): 2.9e-14%2C (30.5%25 identity in 272 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=speE;locus_tag=Rv2601;product=Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY);protein_id=CCP45397.1;transl_table=11
AL123456.3	EMBL	gene	2930070	2930357	.	+	.	ID=gene-Rv2601A;Name=vapB41;gbkey=Gene;gene=vapB41;gene_biotype=protein_coding;locus_tag=Rv2601A
AL123456.3	EMBL	CDS	2930070	2930357	.	+	0	ID=cds-CCP45398.1;Parent=gene-Rv2601A;Dbxref=EnsemblGenomes-Gn:Rv2601A,EnsemblGenomes-Tr:CCP45398,GOA:P9WJ21,InterPro:IPR010985,InterPro:IPR013321,NCBI_GP:CCP45398.1;Name=CCP45398.1;Note=Rv2601A%2C len: 95 aa. Possible vapB41%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv2602%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. O53811|Rv0748 conserved hypothetical protein (88 aa)%2C FASTA scores: opt: 132%2C E(): 0.017%2C(29.25%25 identity in 82 aa overlap)%3B O53218|Rv2493 (73 aa)%2CFASTA scores: opt: 107%2C E(): 0.97%2C (33.75%25 identity in 83 aa overlap)%3B and Q10799|YS71_MYCTU|Rv2871 conserved hypothetical protein from Mycobacterium tuberculosis (85 aa)%2C FASTA scores: opt: 108%2C E(): 0.91%2C (41.00%25 identity in 39 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB41;locus_tag=Rv2601A;product=Possible antitoxin VapB41;protein_id=CCP45398.1;transl_table=11
AL123456.3	EMBL	gene	2930344	2930784	.	+	.	ID=gene-Rv2602;Name=vapC41;gbkey=Gene;gene=vapC41;gene_biotype=protein_coding;locus_tag=Rv2602
AL123456.3	EMBL	CDS	2930344	2930784	.	+	0	ID=cds-CCP45399.1;Parent=gene-Rv2602;Dbxref=EnsemblGenomes-Gn:Rv2602,EnsemblGenomes-Tr:CCP45399,GOA:P9WF59,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45399.1;Name=CCP45399.1;Note=Rv2602%2C (MTCI270A.03c)%2C len: 146 aa. Possible vapC41%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv2601A%2C contains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O50457|Rv1242|MTV006.14 (143 aa)%2CFASTA scores: opt: 147%2C E(): 0.0021%2C (26.25%25 identity in 141 aa overlap)%3B P95023|Rv2530c|MTCY159.26 (139 aa)%2C FASTA scores: opt: 131%2C E(): 0.027%2C (33.35%25 identity in 135 aa overlap)%3B O53812|Rv0749|MTV041.23 (142 aa)%2C FASTA scores: opt: 125%2C E(): 0.072%2C (26.45%25 identity in 140 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC41;locus_tag=Rv2602;product=Possible toxin VapC41. Contains PIN domain.;protein_id=CCP45399.1;transl_table=11
AL123456.3	EMBL	gene	2930805	2931560	.	-	.	ID=gene-Rv2603c;Name=Rv2603c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2603c
AL123456.3	EMBL	CDS	2930805	2931560	.	-	0	ID=cds-CCP45400.1;Parent=gene-Rv2603c;Dbxref=EnsemblGenomes-Gn:Rv2603c,EnsemblGenomes-Tr:CCP45400,GOA:P9WGA5,InterPro:IPR002876,InterPro:IPR017856,InterPro:IPR026563,InterPro:IPR026564,InterPro:IPR029072,NCBI_GP:CCP45400.1;Name=CCP45400.1;Note=Rv2603c%2C (MTCI270A.02)%2C len: 251 aa. Highly conserved protein%2C equivalent to Q49645|YQ03_MYCLE|ML0475|U1177B|B1177_C2_181 hypothetical 26.6 KDA protein from Mycobacterium leprae (251 aa)%2C FASTA scores: opt: 1514%2C E(): 2.2e-84%2C (92.45%25 identity in 251 aa overlap). Also highly similar to Q9L288|SCL2.11c hypothetical 26.8 KDA protein from Streptomyces coelicolor (250 aa)%2C FASTA scores: opt: 1268%2C E(): 1.5e-69%2C (76.7%25 identity in 249 aa overlap)%3B Q9AE12|YFCA hypothetical structural protein from Corynebacterium glutamicum (Brevibacterium flavum) (251 aa)%2C FASTA scores: opt: 1231%2CE(): 2.6e-67%2C (72.9%25 identity in 251 aa overlap)%3B O83487|Y474_TREPA|TP0474 hypothetical protein from Treponema pallidum (245 aa)%2C FASTA scores: opt: 780%2C E(): 4.4e-40%2C (47.75%25 identity in 245 aa overlap)%3B P24237|YEBC_ECOLI|B1864 protein YEBC from Escherichia coli strain K12 (246 aa)%2C FASTA scores: opt: 776%2C E(): 7.6e-40%2C(47.8%25 identity in 249 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2603c;product=Highly conserved protein;protein_id=CCP45400.1;transl_table=11
AL123456.3	EMBL	gene	2931693	2932289	.	-	.	ID=gene-Rv2604c;Name=snoP;gbkey=Gene;gene=snoP;gene_biotype=protein_coding;locus_tag=Rv2604c
AL123456.3	EMBL	CDS	2931693	2932289	.	-	0	ID=cds-CCP45401.1;Parent=gene-Rv2604c;Dbxref=EnsemblGenomes-Gn:Rv2604c,EnsemblGenomes-Tr:CCP45401,GOA:P9WII7,InterPro:IPR002161,InterPro:IPR021196,InterPro:IPR029062,NCBI_GP:CCP45401.1;Name=CCP45401.1;Note=Rv2604c%2C (MTCY01A10.29%2C MTCI270A.01)%2C len: 198 aa. Probable snoP%2C glutamine amidotransferase%2C equivalent (but shorter 21 aa) to Q49637|HISH|B1177_C1_149 HISH protein (belongs to the YFL060C/YAAE/HI1648 family) (alias Q9CCT5|ML0474 hypothetical protein 223 aa) from Mycobacterium leprae (219 aa)%2C FASTA scores: opt: 1069%2CE(): 1.7e-60%2C (83.35%25 identity in 198 aa overlap). Also highly similar to hypothetical proteins or amidotransferases e.g. Q9L287|SCL2.12c hypothetical 21.5 KDA protein from Streptomyces coelicolor (202 aa)%2C FASTA scores: opt: 702%2C E(): 2.3e-37%2C (56.75%25 identity in 192 aa overlap)%3B P37528|YAAE_BACSU hypothetical 21.4 KDA protein from Bacillus subtilis (196 aa)%2C FASTA scores: opt: 608%2CE(): 1.9e-31%2C (48.7%25 identity in 189 aa overlap)%3B Q9KGN5|BH0023 amidotransferase from Bacillus halodurans (196 aa)%2C FASTA scores: opt: 583%2C E(): 7.4e-30%2C (48.7%25 identity in 195 aa overlap)%3B etc. Also some similarity with several proteins from Mycobacterium tuberculosis e.g. O06589|HIS5_MYCTU|Rv1602|MT1638|MTCY336.02c amidotransferase (206 aa)%2C FASTA scores: opt: 154%2C E(): 0.00036%2C (30.6%25 identity in 193 aa overlap). Contains a Pfam match to entry PF01174 SNO glutamine amidotransferase family. Note possibly co-regulated with snzP (Rv2606c).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=snoP;locus_tag=Rv2604c;product=Probable glutamine amidotransferase SnoP;protein_id=CCP45401.1;transl_table=11
AL123456.3	EMBL	gene	2932297	2933142	.	-	.	ID=gene-Rv2605c;Name=tesB2;gbkey=Gene;gene=tesB2;gene_biotype=protein_coding;locus_tag=Rv2605c
AL123456.3	EMBL	CDS	2932297	2933142	.	-	0	ID=cds-CCP45402.1;Parent=gene-Rv2605c;Dbxref=EnsemblGenomes-Gn:Rv2605c,EnsemblGenomes-Tr:CCP45402,GOA:I6X4S7,InterPro:IPR003703,InterPro:IPR025652,InterPro:IPR029069,UniProtKB/TrEMBL:I6X4S7,NCBI_GP:CCP45402.1;Name=CCP45402.1;Note=Rv2605c%2C (MTCY01A10.28)%2C len: 281 aa. Probable tesB2%2C acyl-CoA thioesterase II%2C highly similar to others e.g. Q98EG9|MLL4250 from Rhizobium loti (Mesorhizobium loti) (286 aa)%2C FASTA scores: opt: 563%2C E(): 3.9e-29%2C(47.75%25 identity in 287 aa overlap)%3B CAC47767 from Rhizobium meliloti (Sinorhizobium meliloti) (294 aa)%2C FASTA scores: opt: 553%2C E(): 1.8e-28%2C (49.3%25 identity in 280 aa overlap)%3B P23911|TESB_ECOLI|B0452 from Escherichia coli strain K12 (285 aa)%2C FASTA scores: opt: 487%2C E(): 3.1e-24%2C(41.9%25 identity in 277 aa overlap)%3B etc. Also similar to O06135|TESB1|Rv1618|MTCY01B2.10 acyl-CoA thioesterase II from Mycobacterium tuberculosis (300 aa)%2C FASTA scores: opt: 425%2C E(): 1.1e-21%2C (34.9%25 identity in 278 aa overlap). Belongs to the C/M/P thioester hydrolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tesB2;locus_tag=Rv2605c;product=Probable acyl-CoA thioesterase II TesB2 (TEII);protein_id=CCP45402.1;transl_table=11
AL123456.3	EMBL	gene	2933171	2934070	.	-	.	ID=gene-Rv2606c;Name=snzP;gbkey=Gene;gene=snzP;gene_biotype=protein_coding;locus_tag=Rv2606c
AL123456.3	EMBL	CDS	2933171	2934070	.	-	0	ID=cds-CCP45403.1;Parent=gene-Rv2606c;Dbxref=EnsemblGenomes-Gn:Rv2606c,EnsemblGenomes-Tr:CCP45403,GOA:P9WII9,InterPro:IPR001852,InterPro:IPR011060,InterPro:IPR013785,PDB:4JDY,NCBI_GP:CCP45403.1;Name=CCP45403.1;Note=Rv2606c%2C (MTCY01A10.27)%2C len: 299 aa. Probable snzP%2Cpyridoxine biosynthesis protein. Highly similar to O07145|YQ06_MYCLE|ML0450|MLCL581.12c possible pyridoxine biosynthesis protein from Mycobacterium leprae (307 aa)%2CFASTA scores: opt: 1686%2C E(): 1.5e-95%2C (89.7%25 identity in 291 aa overlap). Also highly similar to several pyridoxine biosynthesis proteins and hypothetical proteins e.g. Q9L286|SCL2.13c hypothetical 32.2 KDA protein from Streptomyces coelicolor (303 aa)%2C FASTA scores: opt: 1461%2CE(): 7.6e-82%2C (76.8%25 identity in 293 aa overlap)%3B O14027|YEM4_SCHPO|SPAC29B12.04 putative stress-induced protein from Schizosaccharomyces pombe (Fission yeast) (296 aa)%2C FASTA scores: opt: 1318%2C E(): 3.8e-73%2C (70.35%25 identity in 290 aa overlap)%3B Q9UW83|PYROA protein involved in pyridoxine biosynthesis from Emericella nidulans (Aspergillus nidulans) (see citation below) (304 aa)%2C FASTA scores: opt: 1288%2C E(): 2.6e-71%2C (67.9%25 identity in 302 aa overlap)%3B etc. Contains Pfam match to entry PF01680%2CSOR_SNZ family. Contains PS01235 Uncharacterized protein family UPF0019 signature. Belongs to the SOR_SNZ family. Note possibly co-regulated with snoP (Rv2604c).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=snzP;locus_tag=Rv2606c;product=Possible pyridoxine biosynthesis protein SnzP;protein_id=CCP45403.1;transl_table=11
AL123456.3	EMBL	gene	2934198	2934872	.	+	.	ID=gene-Rv2607;Name=pdxH;gbkey=Gene;gene=pdxH;gene_biotype=protein_coding;locus_tag=Rv2607
AL123456.3	EMBL	CDS	2934198	2934872	.	+	0	ID=cds-CCP45404.1;Parent=gene-Rv2607;Dbxref=EnsemblGenomes-Gn:Rv2607,EnsemblGenomes-Tr:CCP45404,GOA:P9WIJ1,InterPro:IPR000659,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019576,InterPro:IPR019740,PDB:2A2J,NCBI_GP:CCP45404.1;Name=CCP45404.1;Note=Rv2607%2C (MTCY01A10.26c)%2C len: 224 aa. Probable pdxH%2Cpyridoxinephosphate oxidase%2C equivalent to O33065|PDXH_MYCLE|ML2131|MLCB57.46 pyridoxamine 5'-phosphate oxidase from Mycobacterium leprae (219 aa)%2CFASTA scores: opt: 1038%2C E(): 8.3e-61%2C (67.1%25 identity in 219 aa overlap). Also similar to others e.g. Q9I4S5|PDXH|PA1049 from Pseudomonas aeruginosa (215 aa)%2CFASTA scores: opt: 608%2C E(): 1.1e-32%2C (49.55%25 identity in 218 aa overlap)%3B Q9K3V7|SCD10.19c from Streptomyces coelicolor (234 aa)%2C FASTA scores: opt: 600%2C E(): 3.9e-32%2C(42.3%25 identity in 234 aa overlap)%3B P28225|PDXH_ECOLI|B1638 from Escherichia coli strain K12 (217 aa)%2C FASTA scores: opt: 533%2C E(): 8.9e-28%2C (40.3%25 identity in 216 aa overlap)%3B etc. Contains a match to Pfam entry PF01243 Pyridoxamine 5'-phosphate oxidase. Belongs to the pyridoxamine 5'-phosphate oxidase family. Cofactor: FMN.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pdxH;locus_tag=Rv2607;product=Probable pyridoxamine 5'-phosphate oxidase PdxH (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase);protein_id=CCP45404.1;transl_table=11
AL123456.3	EMBL	gene	2935046	2936788	.	+	.	ID=gene-Rv2608;Name=PPE42;gbkey=Gene;gene=PPE42;gene_biotype=protein_coding;locus_tag=Rv2608
AL123456.3	EMBL	CDS	2935046	2936788	.	+	0	ID=cds-CCP45405.1;Parent=gene-Rv2608;Dbxref=EnsemblGenomes-Gn:Rv2608,EnsemblGenomes-Tr:CCP45405,GOA:P9WHZ5,InterPro:IPR000030,InterPro:IPR002989,InterPro:IPR013228,NCBI_GP:CCP45405.1;Name=CCP45405.1;Note=Rv2608%2C (MTCY01A10.25c)%2C len: 580 aa. PPE42%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. O06828|Rv1430|MTCY493.24c from Mycobacterium tuberculosis (528 aa)%2C FASTA scores: opt: 1004%2C E(): 5.9e-48%2C (56.05%25 identity in 307 aa overlap).;gbkey=CDS;gene=PPE42;locus_tag=Rv2608;product=PPE family protein PPE42;protein_id=CCP45405.1;transl_table=11
AL123456.3	EMBL	gene	2936810	2937865	.	-	.	ID=gene-Rv2609c;Name=Rv2609c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2609c
AL123456.3	EMBL	CDS	2936810	2937865	.	-	0	ID=cds-CCP45406.1;Parent=gene-Rv2609c;Dbxref=EnsemblGenomes-Gn:Rv2609c,EnsemblGenomes-Tr:CCP45406,GOA:I6YDV4,InterPro:IPR000086,InterPro:IPR015797,InterPro:IPR020084,UniProtKB/TrEMBL:I6YDV4,NCBI_GP:CCP45406.1;Name=CCP45406.1;Note=Rv2609c%2C (MTCY01A10.24)%2C len: 351 aa. Probable conserved membrane protein%2C equivalent to O07146|MLCL581.13c|ML0451 hypothetical 37.9 KDA protein from Mycobacterium leprae (349 aa)%2C FASTA scores: opt: 1675%2C E(): 1.4e-95%2C (77.85%25 identity in 334 aa overlap). Also similar to hypothetical proteins: O69888|SC2E1.17|mutt hypothetical 19.4 KDA protein from Streptomyces coelicolor and Streptomyces lividans (172 aa)%2C FASTA scores: opt: 345%2CE(): 3.5e-14%2C (44.7%25 identity in 161 aa overlap)%3B Q9L285|SCL2.14c hypothetical 19.8 KDA protein from Streptomyces coelicolor (180 aa)%2C FASTA scores: opt: 179%2CE(): 0.00056%2C (43.25%25 identity in 171 aa overlap)%3B and Q9RYE5|DR0004 mutt/NUDIX family protein from Deinococcus radiodurans (350 aa)%2C FASTA scores: opt: 153%2C E(): 0.037%2C(33.35%25 identity in 123 aa overlap). Contains PS00893 mutT domain signature. Belongs to the mutt/NUDIX family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00893;locus_tag=Rv2609c;product=Probable conserved membrane protein;protein_id=CCP45406.1;transl_table=11
AL123456.3	EMBL	gene	2937865	2939001	.	-	.	ID=gene-Rv2610c;Name=pimA;gbkey=Gene;gene=pimA;gene_biotype=protein_coding;locus_tag=Rv2610c
AL123456.3	EMBL	CDS	2937865	2939001	.	-	0	ID=cds-CCP45407.1;Parent=gene-Rv2610c;Dbxref=EnsemblGenomes-Gn:Rv2610c,EnsemblGenomes-Tr:CCP45407,GOA:P9WMZ5,InterPro:IPR001296,InterPro:IPR028098,NCBI_GP:CCP45407.1;Name=CCP45407.1;Note=Rv2610c%2C (MTCY01A10.23)%2C len: 378 aa. PimA%2Calpha-mannosyltransferase (see citations below)%2C equivalent to O07147|MLCL581.14c|ML0452 putative glycosyltransferase from Mycobacterium leprae (374 aa)%2C FASTA scores: opt: 2044%2C E(): 8.8e-118%2C (82.25%25 identity in 378 aa overlap). N-terminus (from aa 1 to 27) equivalent to Q9FY7 putative alpha-mannosyl transferase (fragment) from Mycobacterium smegmatis (27 aa)%2C blastp scores: 57.4 bits (137)%2C E(): 3e-8%2C Identities %3D 25/27 (92%25)%2C Positives %3D 27/27 (99%25) (see citation below). Also highly similar to Q9L284|SCL2.15c putative sugar transferase from Streptomyces coelicolor (387 aa)%2C FASTA scores: opt: 1222%2CE(): 1.8e-67%2C (52.95%25 identity in 376 aa overlap)%3B and similar in part to various proteins e.g. Q9YA73|APE2066 long hypothetical N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein from Aeropyrum pernix (392 aa)%2C FASTA scores: opt: 434%2C E(): 3e-19%2C (31.5%25 identity in 378 aa overlap)%3B Q9UZA1|PAB0827 galactosyltransferase or LPS biosynthesis RFBU related protein from Pyrococcus abyssi (371 aa)%2C FASTA scores: opt: 382%2C E(): 4.3e-16%2C (28.2%25 identity in 383 aa overlap)%3B O26275|MTH173 LPS biosynthesis RFBU related protein from Methanothermobacter thermautotrophicus (382 aa)%2C FASTA scores: opt: 372%2C E(): 1.8e-15%2C (28.4%25 identity in 391 aa overlap)%3B etc. Shows also some similarity with O05313|Rv1212c|MTCI364.24c hypothetical 41.5 KDA protein from Mycobacterium tuberculosis (387 aa)%2C FASTA scores: opt: 232%2C E(): 1.1e -07%2C (28.4%25 identity in 402 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;gene=pimA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2610c;product=Alpha-mannosyltransferase PimA;protein_id=CCP45407.1;transl_table=11
AL123456.3	EMBL	gene	2939012	2939962	.	-	.	ID=gene-Rv2611c;Name=Rv2611c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2611c
AL123456.3	EMBL	CDS	2939012	2939962	.	-	0	ID=cds-CCP45408.1;Parent=gene-Rv2611c;Dbxref=EnsemblGenomes-Gn:Rv2611c,EnsemblGenomes-Tr:CCP45408,GOA:P9WMB5,InterPro:IPR004960,NCBI_GP:CCP45408.1;Name=CCP45408.1;Note=Rv2611c%2C (MTCY01A10.22)%2C len: 316 aa. Probable acyltransferase %2C equivalent to O07148|MLCL581.15c|ML0453 hypothetical 35.4 KDA protein from Mycobacterium leprae (320 aa)%2C FASTA scores: opt: 1529%2C E(): 5e-90%2C (71.45%25 identity in 312 aa overlap)%3B and equivalent to Q9F7Y8 putative acyltransferase from Mycobacterium smegmatis (303 aa)%2C FASTA scores: opt: 1464%2C E(): 6.5e-86%2C (72.15%25 identity in 291 aa overlap) (see citation below). Also highly similar to Q9L283|SCL2.16c putative acyltransferase from Streptomyces coelicolor (311 aa)%2C FASTA scores: opt: 810%2C E(): 2.8e-44%2C (47.7%25 identity in 302 aa overlap)%3B and similar to other acyltransferases e.g. Q9F0N3 acyltransferase from Campylobacter jejuni (295 aa)%2C FASTA scores: opt: 207%2C E(): 6.4e-06%2C (20.45%25 identity in 220 aa overlap)%3B Q9K379 acyltransferase (lipid a biosynthesis acyltransferase) from Campylobacter jejuni (295 aa)%2C FASTA scores: opt: 203%2C E(): 1.1e-05%2C (20.0%25 identity in 220 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2611c;product=Probable acyltransferase;protein_id=CCP45408.1;transl_table=11
AL123456.3	EMBL	gene	2939959	2940612	.	-	.	ID=gene-Rv2612c;Name=pgsA1;gbkey=Gene;gene=pgsA1;gene_biotype=protein_coding;gene_synonym=pgsA;locus_tag=Rv2612c
AL123456.3	EMBL	CDS	2939959	2940612	.	-	0	ID=cds-CCP45409.1;Parent=gene-Rv2612c;Dbxref=EnsemblGenomes-Gn:Rv2612c,EnsemblGenomes-Tr:CCP45409,GOA:P9WPG7,InterPro:IPR000462,NCBI_GP:CCP45409.1;Name=CCP45409.1;Note=Rv2612c%2C (MTCY01A10.21)%2C len: 217 aa. pgsA1 (previously known as pgsA)%2C PI synthase/CDP-diacylglyceride--inositol phosphatidyltransferase%2C transmembrane protein%2C equivalent to O07149|MLCL581.16c|PGSA|ML0454 putative phosphatidyltransferase from Mycobacterium leprae (239 aa)%2CFASTA scores: opt: 1141%2C E(): 4.1e-70%2C (79.35%25 identity in 213 aa overlap)%3B and Q9F7Y9|PGSA phosphatidylinositol synthase from Mycobacterium smegmatis (222 aa)%2C FASTA scores: opt: 981%2C E(): 2.7e-59%2C (67.3%25 identity in 217 aa overlap) (see citation below). Also similar to other proteins e.g. Q9L282|SCL2.17c putative membrane transferase from Streptomyces coelicolor (241 aa)%2C FASTA scores: opt: 564%2C E(): 4.9e-31%2C (43.4%25 identity in 212 aa overlap)%3B Q9UYD0|PGSA-like|PAB1041 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Pyrococcus abyssi (186 aa)%2CFASTA scores: opt: 264%2C E(): 8.4e-11%2C (33.15%25 identity in 190 aa overlap)%3B Q9HQS2|PGSA|VNG1030G CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase from Halobacterium sp. strain NRC-1 (199 aa)%2C FASTA scores: opt: 249%2C E(): 9.1e-10%2C(32.1%25 identity in 193 aa overlap)%3B etc. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Note that in Mycobacterium smegmatis%2C the psgA homologue is essential to the survival of the bacteria and seems cannot be compensated by any other enzyme of Mycobacterium smegmatis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pgsA1;inference=protein motif:PROSITE:PS00379;locus_tag=Rv2612c;product=PI synthase PgsA1 (phosphatidylinositol synthase) (CDP-diacylglycerol--inositol-3-phosphatidyltransferase);protein_id=CCP45409.1;transl_table=11
AL123456.3	EMBL	gene	2940609	2941196	.	-	.	ID=gene-Rv2613c;Name=Rv2613c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2613c
AL123456.3	EMBL	CDS	2940609	2941196	.	-	0	ID=cds-CCP45410.1;Parent=gene-Rv2613c;Dbxref=EnsemblGenomes-Gn:Rv2613c,EnsemblGenomes-Tr:CCP45410,GOA:P9WMK9,InterPro:IPR001310,InterPro:IPR011146,PDB:3ANO,NCBI_GP:CCP45410.1;Name=CCP45410.1;Note=Rv2613c%2C (MTCY01A10.20A)%2C len: 195 aa. Conserved protein%2C equivalent to Q9CCU0|ML0455 hypothetical protein from Mycobacterium leprae (206 aa)%2C FASTA scores: opt: 1074%2C E(): 7.4e-62%2C (84.7%25 identity in 196 aa overlap)%3B and highly similar%2C but longer 18 aa%2C to O07150|MLCL581.17c hypothetical 20.7 KDA protein from Mycobacterium leprae (186 aa)%2C FASTA scores: opt: 1038%2C E(): 1.4e-59%2C (89.7%25 identity in 175 aa overlap). Also highly similar to other hypothetical proteins (often Hit family member) e.g. Q9F7Z0 from Mycobacterium smegmatis (see citation below) (205 aa)%2CFASTA scores: opt: 975%2C E(): 1.6e-55%2C (79.35%25 identity in 184 aa overlap)%3B Q9L279|SCL2.20 from Streptomyces coelicolor (186 aa)%2C FASTA scores: opt: 638%2C E(): 5.8e-34%2C(52.85%25 identity in 176 aa overlap)%3B Q9YFX8|APE0122 from Aeropyrum pernix (184 aa)%2C FASTA scores: opt: 515%2C E(): 4.4e-26%2C (45.9%25 identity in 159 aa overlap)%3B etc. It seems the Rv2613c and downstream ORF Rv2612c|psgA1 are expressed from the same promoter (see citation below) and that Rv2613c should be involved in lipid metabolism.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2613c;product=Conserved protein;protein_id=CCP45410.1;transl_table=11
AL123456.3	EMBL	gene	2941189	2943267	.	-	.	ID=gene-Rv2614c;Name=thrS;gbkey=Gene;gene=thrS;gene_biotype=protein_coding;locus_tag=Rv2614c
AL123456.3	EMBL	CDS	2941189	2943267	.	-	0	ID=cds-CCP45411.1;Parent=gene-Rv2614c;Dbxref=EnsemblGenomes-Gn:Rv2614c,EnsemblGenomes-Tr:CCP45411,GOA:P9WFT5,InterPro:IPR002314,InterPro:IPR002320,InterPro:IPR004154,InterPro:IPR006195,InterPro:IPR012947,InterPro:IPR018163,NCBI_GP:CCP45411.1;Name=CCP45411.1;Note=Rv2614c%2C (MT2689%2C MTCY01A10.20)%2C len: 692 aa. Probable thrS%2C threonyl-tRNA synthetase (Threonine--tRNA ligase)%2C equivalent to O07151|SYT_MYCLE|THRS|ML0456|MLCL581.18c threonyl-tRNA synthetase from Mycobacterium leprae (702 aa)%2C FASTA scores: opt: 3988%2C E(): 0%2C (84.05%25 identity in 702 aa overlap). Also highly similar to others e.g. Q9L278|THRS from Streptomyces coelicolor (658 aa)%2C FASTA scores: opt: 1982%2C E(): 5.1e-114%2C (65.1%25 identity in 659 aa overlap)%3B P56881|SYT_THETH|THRS from Thermus aquaticus (subsp. thermophilus) (659 aa)%2C FASTA scores: opt: 1551%2C E(): 1.5e-87%2C (46.5%25 identity in 650 aa overlap)%3B P00955|SYT_ECOLI from Escherichia coli (642 aa)%2C FASTA scores: opt: 946%2C E(): 0%2C (40.7%25 identity in 612 aa overl ap)%3B etc. Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Belongs to class-II aminoacyl-tRNA synthetase family. Cofactor: binds 1 zinc ion (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thrS;inference=protein motif:PROSITE:PS00339;locus_tag=Rv2614c;product=Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase);protein_id=CCP45411.1;transl_table=11
AL123456.3	EMBL	gene	2943376	2943603	.	+	.	ID=gene-Rv2614A;Name=Rv2614A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2614A
AL123456.3	EMBL	CDS	2943376	2943603	.	+	0	ID=cds-CCP45412.1;Parent=gene-Rv2614A;Dbxref=EnsemblGenomes-Gn:Rv2614A,EnsemblGenomes-Tr:CCP45412,UniProtKB/TrEMBL:Q79FC4,NCBI_GP:CCP45412.1;Name=CCP45412.1;Note=Rv2614A%2C len: 75 aa. Conserved hypothetical protein. The region from aa 10-35 is similar to part of C-terminal part of several triosephosphate isomerases e.g. P46711|TPIS_MYCLE|TPIA|TPI|ML0572|B1496_C1_127 from Mycobacterium leprae (261 aa)%2C FASTA scores: opt: 112%2C E(): 0.95%2C (60.0%25 identity in 25 aa overlap)%3B and O08408|TPIS_MYCTU|TPIA|TPI|Rv1438|MT1482|MTCY493.16c from Mycobacterium tuberculosis (261 aa)%2C FASTA scores: opt: 104%2C E(): 3.3%2C (60.0%25 identity in 25 aa overlap)%3B P19583|TPIS_CORGL|TPIA|TPI from Corynebacterium glutamicum (Brevibacterium flavum) (259 aa)%2C FASTA scores: opt: 100%2CE(): 6%2C (45.45%25 identity in 33 aa overlap)%3B etc. Triosephosphate isomerases play an important role in several metabolic pathways (catalytic activity: D-glyceraldehyde 3-phosphate %3D dihydroxy-acetone phosphate). Nucleotide position 2943411 in the genome sequence has been corrected%2C T:C resulting in L12L.;gbkey=CDS;locus_tag=Rv2614A;product=Conserved hypothetical protein;protein_id=CCP45412.1;transl_table=11
AL123456.3	EMBL	gene	2943600	2944985	.	-	.	ID=gene-Rv2615c;Name=PE_PGRS45;gbkey=Gene;gene=PE_PGRS45;gene_biotype=protein_coding;locus_tag=Rv2615c
AL123456.3	EMBL	CDS	2943600	2944985	.	-	0	ID=cds-CCP45413.1;Parent=gene-Rv2615c;Dbxref=EnsemblGenomes-Gn:Rv2615c,EnsemblGenomes-Tr:CCP45413,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FC3,NCBI_GP:CCP45413.1;Name=CCP45413.1;Note=Rv2615c%2C (MTCY01A10.19)%2C len: 461 aa. PE_PGRS45%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to many e.g. P71664|Rv1396c|MTCY21B4.13c from Mycobacterium tuberculosis (576 aa)%2C FASTA scores: opt: 1629%2C E(): 4.8e-58%2C (56.65%25 identity in 482 aa overlap). Equivalent to AAK47006 from Mycobacterium tuberculosis strain CDC1551 (476 aa) but shorter 15 aa.;gbkey=CDS;gene=PE_PGRS45;locus_tag=Rv2615c;product=PE-PGRS family protein PE_PGRS45;protein_id=CCP45413.1;transl_table=11
AL123456.3	EMBL	gene	2945330	2945830	.	+	.	ID=gene-Rv2616;Name=Rv2616;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2616
AL123456.3	EMBL	CDS	2945330	2945830	.	+	0	ID=cds-CCP45414.1;Parent=gene-Rv2616;Dbxref=EnsemblGenomes-Gn:Rv2616,EnsemblGenomes-Tr:CCP45414,GOA:O06198,InterPro:IPR014457,InterPro:IPR018960,UniProtKB/TrEMBL:O06198,NCBI_GP:CCP45414.1;Name=CCP45414.1;Note=Rv2616%2C (MTCY01A10.18c)%2C len: 166 aa. Conserved protein%2C highly similar to bacterial proteins: Q9L1G0|SC3D11.02c hypothetical 20.3 KDA protein from Streptomyces coelicolor (188 aa)%2C FASTA scores: opt: 407%2CE(): 2.3e-20%2C (44.0%25 identity in 159 aa overlap)%3B Q9X945 A3(2) glycogen metabolism cluster from Streptomyces coelicolor (134 aa)%2C FASTA scores: opt: 330%2C E(): 2.5e-15%2C(46.65%25 identity in 120 aa overlap) (N-terminus shorter)%3B Q9RST8|DR2035 conserved hypothetical protein from Deinococcus radiodurans (198 aa)%2C FASTA scores: opt: 228%2CE(): 2.4e-08%2C (35.1%25 identity in 168 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2616;product=Conserved protein;protein_id=CCP45414.1;transl_table=11
AL123456.3	EMBL	gene	2945847	2946287	.	-	.	ID=gene-Rv2617c;Name=Rv2617c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2617c
AL123456.3	EMBL	CDS	2945847	2946287	.	-	0	ID=cds-CCP45415.1;Parent=gene-Rv2617c;Dbxref=EnsemblGenomes-Gn:Rv2617c,EnsemblGenomes-Tr:CCP45415,GOA:I6XER9,InterPro:IPR011637,UniProtKB/TrEMBL:I6XER9,NCBI_GP:CCP45415.1;Name=CCP45415.1;Note=Rv2617c%2C (MTCY01A10.17)%2C len: 146 aa. Probable transmembrane protein%2C showing some similarity to hypothetical or membrane proteins e.g. CAC47207|SMC00744 putative transport protein transmembrane from Rhizobium meliloti (Sinorhizobium meliloti) (399 aa)%2C FASTA scores: opt: 108%2C E(): 5.5%2C (29.15%25 identity in 144 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2617c;product=Probable transmembrane protein;protein_id=CCP45415.1;transl_table=11
AL123456.3	EMBL	gene	2946434	2947111	.	+	.	ID=gene-Rv2618;Name=Rv2618;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2618
AL123456.3	EMBL	CDS	2946434	2947111	.	+	0	ID=cds-CCP45416.1;Parent=gene-Rv2618;Dbxref=EnsemblGenomes-Gn:Rv2618,EnsemblGenomes-Tr:CCP45416,InterPro:IPR011991,UniProtKB/TrEMBL:O06195,NCBI_GP:CCP45416.1;Name=CCP45416.1;Note=Rv2618%2C (MTCY01A10.15c)%2C len: 225 aa. Conserved hypothetical protein%2C similar in part to Q9EWQ9|SC4C2.03 conserved hypothetical protein from Streptomyces coelicolor (159 aa)%2C FASTA scores: opt: 235%2C E(): 1.3e-07%2C (43.7%25 identity in 103 aa overlap)%3B Q9HLM6|TA0201 hypothetical protein from Thermoplasma acidophilum (215 aa)%2C FASTA scores: opt: 164%2C E(): 0.0038%2C (23.4%25 identity in 201 aa overlap)%3B and to mycobacterial proteins e.g. O06191|Rv2621c|MTCY01A10.11 hypothetical 24.2 KDA protein from Mycobacterium tuberculosis (224 aa)%2C FASTA scores: opt: 149%2C E(): 0.033%2C (28.05%25 identity in 196 aa overlap).;gbkey=CDS;locus_tag=Rv2618;product=Conserved hypothetical protein;protein_id=CCP45416.1;transl_table=11
AL123456.3	EMBL	gene	2947096	2947449	.	-	.	ID=gene-Rv2619c;Name=Rv2619c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2619c
AL123456.3	EMBL	CDS	2947096	2947449	.	-	0	ID=cds-CCP45417.1;Parent=gene-Rv2619c;Dbxref=EnsemblGenomes-Gn:Rv2619c,EnsemblGenomes-Tr:CCP45417,InterPro:IPR011051,InterPro:IPR013096,InterPro:IPR014710,UniProtKB/TrEMBL:O06194,NCBI_GP:CCP45417.1;Name=CCP45417.1;Note=Rv2619c%2C (MTCY01A10.14)%2C len: 117 aa. Conserved protein%2C highly similar to Q9L0F3|SCD31.14 hypothetical 11.6 KDA protein from Streptomyces coelicolor (110 aa)%2CFASTA scores: opt: 407%2C E(): 2.3e-21%2C (55.95%25 identity in 109 aa overlap). Also similarity with other short bacterial hypothetical proteins e.g. Q9F8B9 hypothetical 12.4 KDA protein from Streptococcus agalactiae (112 aa)%2C FASTA scores: opt: 143%2C E(): 0.0032%2C (32.45%25 identity in 74 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2619c;product=Conserved protein;protein_id=CCP45417.1;transl_table=11
AL123456.3	EMBL	gene	2947462	2947887	.	-	.	ID=gene-Rv2620c;Name=Rv2620c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2620c
AL123456.3	EMBL	CDS	2947462	2947887	.	-	0	ID=cds-CCP45418.1;Parent=gene-Rv2620c;Dbxref=EnsemblGenomes-Gn:Rv2620c,EnsemblGenomes-Tr:CCP45418,GOA:I6Y9U6,UniProtKB/TrEMBL:I6Y9U6,NCBI_GP:CCP45418.1;Name=CCP45418.1;Note=Rv2620c%2C (MTCY01A10.13)%2C len: 141 aa. Probable conserved transmembrane protein%2C highly similar to O54184|SC7H1.25 hypothetical 14.6 KDA protein from Streptomyces coelicolor (144 aa)%2C FASTA scores: opt: 459%2CE(): 1.4e-22%2C (56.45%25 identity in 140 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2620c;product=Probable conserved transmembrane protein;protein_id=CCP45418.1;transl_table=11
AL123456.3	EMBL	gene	2947884	2948558	.	-	.	ID=gene-Rv2621c;Name=Rv2621c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2621c
AL123456.3	EMBL	CDS	2947884	2948558	.	-	0	ID=cds-CCP45419.1;Parent=gene-Rv2621c;Dbxref=EnsemblGenomes-Gn:Rv2621c,EnsemblGenomes-Tr:CCP45419,InterPro:IPR011991,UniProtKB/TrEMBL:I6Y187,NCBI_GP:CCP45419.1;Name=CCP45419.1;Note=Rv2621c%2C (MTCY01A10.11)%2C len: 224 aa. Possible transcriptional regulator%2C similar in part to Q49688|MLCL536.29c|ML0592 putative DNA-binding protein from Mycobacterium leprae (254 aa)%2C FASTA scores: opt: 168%2C E(): 0.0018%2C (29.75%25 identity in 222 aa overlap). Shows similarity with Q9XAD0|SCC22.08c putative DNA-binding protein from Streptomyces coelicolor (252 aa)%2C FASTA scores: opt: 148%2C E(): 0.032%2C (29.4%25 identity in 204 aa overlap)%3B and Q9RVM8|DR0999 conserved hypothetical protein from Deinococcus radiodurans (225 aa)%2C FASTA scores: opt: 195%2C E(): 3.3e-05%2C (29.6%25 identity in 213 aa overlap). Also some similarity with O06195|Rv2618|MTCY01A10.15c from Mycobacterium tuberculosis (225 aa)%2C FASTA scores: opt: 149%2C E(): 0.025%2C (28.95%25 identity in 197 aa overlap). Contains helix-turn-helix motif at aa 31-52 (Score 1662%2C+4.85 SD).;gbkey=CDS;locus_tag=Rv2621c;product=Possible transcriptional regulatory protein;protein_id=CCP45419.1;transl_table=11
AL123456.3	EMBL	gene	2948636	2949457	.	+	.	ID=gene-Rv2622;Name=Rv2622;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2622
AL123456.3	EMBL	CDS	2948636	2949457	.	+	0	ID=cds-CCP45420.1;Parent=gene-Rv2622;Dbxref=EnsemblGenomes-Gn:Rv2622,EnsemblGenomes-Tr:CCP45420,GOA:I6XES4,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:I6XES4,NCBI_GP:CCP45420.1;Name=CCP45420.1;Note=Rv2622%2C (MTCY01A10.10c)%2C len: 273 aa. Possible methyltransferase%2C similar in part to others e.g. AAK75664|SP1578 putative methyltransferase from Streptococcus pneumoniae (252 aa)%2C FASTA scores: opt: 406%2CE(): 6.6e-18%2C (32.65%25 identity in 251 aa overlap)%3B Q9F8B8 methyltransferase from Streptococcus agalactiae (254 aa)%2CFASTA scores: opt: 381%2C E(): 2.3e-16%2C (31.75%25 identity in 252 aa overlap)%3B Q9RJB6|SCF91.08 putative methyltransferase from Streptomyces coelicolor (231 aa)%2C FASTA scores: opt: 159%2C E(): 0.0091%2C (33.1%25 identity in 151 aa overlap)%3B etc. Also similar in part to several hypothetical proteins e.g. Q99YR0|SPY1582 hypothetical protein from Streptococcus pyogenes (251 aa)%2C FASTA scores: opt: 397%2C E(): 2.3e-17%2C(36.3%25 identity in 248 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2622;product=Possible methyltransferase (methylase);protein_id=CCP45420.1;transl_table=11
AL123456.3	EMBL	gene	2949593	2950486	.	+	.	ID=gene-Rv2623;Name=TB31.7;gbkey=Gene;gene=TB31.7;gene_biotype=protein_coding;locus_tag=Rv2623
AL123456.3	EMBL	CDS	2949593	2950486	.	+	0	ID=cds-CCP45421.1;Parent=gene-Rv2623;Dbxref=EnsemblGenomes-Gn:Rv2623,EnsemblGenomes-Tr:CCP45421,GOA:P9WFD7,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,PDB:2JAX,PDB:3CIS,NCBI_GP:CCP45421.1;Name=CCP45421.1;Note=Rv2623%2C (MTCY01A10.09c)%2C len: 297 aa. TB31.7%2Cuniversal stress protein family protein%2C highly similar to hypothetical proteins from Mycobacterium tuberculosis e.g. Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa)%2C FASTA scores: opt: 1076%2C E(): 1.4e-60%2C (55.25%25 identity in 295 aa overlap)%3B O53472|Rv2026c|MTV018.13c (294 aa)%2C FASTA scores: opt: 988%2C E(): 4.8e-55%2C (51.5%25 identity in 295 aa overlap)%3B Q10862|YJ96_MYCTU|Rv1996|MT2052|MTCY39.23c (317 aa)%2C FASTA scores: opt: 688%2C E(): 4.1e-36%2C (45.1%25 identity in 315 aa overlap)%3B etc. Also similar to several Streptomyces proteins e.g. Q9RIZ8|SCJ1.16c conserved hypothetical protein from Streptomyces coelicolor (294 aa)%2C FASTA scores: opt: 407%2C E(): 2e-18%2C (32.65%25 identity in 303 aa overlap)%3B and other bacterial hypothetical proteins e.g. Q9HPP5|VNG1536 from Halobacterium sp (147 aa)%2C FASTA scores: opt: 180%2C E(): 0.00022%2C (31.65%25 identity in 139 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C 2008). Binds ATP.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB31.7;locus_tag=Rv2623;product=Universal stress protein family protein TB31.7;protein_id=CCP45421.1;transl_table=11
AL123456.3	EMBL	gene	2950489	2951307	.	-	.	ID=gene-Rv2624c;Name=Rv2624c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2624c
AL123456.3	EMBL	CDS	2950489	2951307	.	-	0	ID=cds-CCP45422.1;Parent=gene-Rv2624c;Dbxref=EnsemblGenomes-Gn:Rv2624c,EnsemblGenomes-Tr:CCP45422,GOA:P9WFD5,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,NCBI_GP:CCP45422.1;Name=CCP45422.1;Note=Rv2624c%2C (MTCY01A10.08)%2C len: 272 aa. Universal stress protein family protein%2C similar to several Streptomyces proteins e.g. Q9RIY5|SCJ1.29c hypothetical 30.1 KDA protein from Streptomyces coelicolor (283 aa)%2CFASTA scores: opt: 260%2C E(): 5e-09%2C (32.05%25 identity in 290 aa overlap). Also similar to Mycobacterium tuberculosis proteins O53474|Rv2028c|MTV018.15c (279 aa)%2C FASTA scores: opt: 563%2C E(): 7e-28%2C (36.85%25 identity in 266 aa overlap)%3B P95192|Rv3134c|MTCY03A2.240 (268 aa)%2C FASTA scores: opt: 458%2C E(): 2.3e-21%2C (36.55%25 identity in 271 aa overlap)%3B Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.12 (295 aa)%2C FASTA scores: opt: 199%2C E(): 3.2e-05%2C (29.35%25 identity in 286 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2624c;product=Universal stress protein family protein;protein_id=CCP45422.1;transl_table=11
AL123456.3	EMBL	gene	2951322	2952503	.	-	.	ID=gene-Rv2625c;Name=Rv2625c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2625c
AL123456.3	EMBL	CDS	2951322	2952503	.	-	0	ID=cds-CCP45423.1;Parent=gene-Rv2625c;Dbxref=EnsemblGenomes-Gn:Rv2625c,EnsemblGenomes-Tr:CCP45423,GOA:P9WHR1,InterPro:IPR000644,InterPro:IPR008915,InterPro:IPR016483,NCBI_GP:CCP45423.1;Name=CCP45423.1;Note=Rv2625c%2C (MTCY01A10.07)%2C len: 393 aa. Probable conserved transmembrane ala-%2C leu-rich protein%2C similar to many hypothetical or membrane proteins e.g. Q55518|Y528_SYNY3|SLL0528 potential integral membrane protein from Synechocystis sp. strain PCC 6803 (379 aa)%2CFASTA scores: opt: 552%2C E(): 5.6e-26%2C (30.75%25 identity in 374 aa overlap)%3B Q9RJ56|SCI41.35c hypothetical 39.8 KDA protein from Streptomyces coelicolor (374 aa)%2C FASTA scores: opt: 419%2C E(): 5.7e-18%2C (31.6%25 identity in 383 aa overlap)%3B CAC49448|SMB20925 conserved hypothetical membrane protein from Rhizobium meliloti (Sinorhizobium meliloti) (372 aa)%2C FASTA scores: opt: 401%2C E(): 6.9e-17%2C (29.5%25 identity in 383 aa overlap)%3B etc. Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv2625c;product=Probable conserved transmembrane alanine and leucine rich protein;protein_id=CCP45423.1;transl_table=11
AL123456.3	EMBL	gene	2952562	2952993	.	-	.	ID=gene-Rv2626c;Name=hrp1;gbkey=Gene;gene=hrp1;gene_biotype=protein_coding;locus_tag=Rv2626c
AL123456.3	EMBL	CDS	2952562	2952993	.	-	0	ID=cds-CCP45424.1;Parent=gene-Rv2626c;Dbxref=EnsemblGenomes-Gn:Rv2626c,EnsemblGenomes-Tr:CCP45424,GOA:P9WJA3,InterPro:IPR000644,PDB:1XKF,PDB:1Y5H,NCBI_GP:CCP45424.1;Name=CCP45424.1;Note=Rv2626c%2C (MTCY01A10.06)%2C len: 143 aa. Hrp1%2C hypoxic response protein 1%2C similar to CAC49670|SMB21441 putative inosine-5'-monophosphate dehydrogenase protein from Rhizobium meliloti (Sinorhizobium meliloti) (120 aa)%2C FASTA scores: opt: 287%2C E(): 6.6e-12%2C (43.75%25 identity in 112 aa overlap) (has its N-terminus shorter 27 aa)%3B AAK78655|CAC0678 CBS domains from Clostridium acetobutylicum (142 aa)%2C FASTA scores: opt: 276%2C E(): 3.9e-11%2C (35.65%25 identity in 115 aa overlap)%3B Q9K9P0|BH2605 BH2605 protein from Bacillus halodurans (142 aa)%2C FASTA scores: opt: 276%2C E(): 3.9e-11%2C (35.65%25 identity in 115 aa overlap)%3B etc. Also some similarity to P71737|Rv2406c|MTCY253.14 hypothetical 15.1 KDA protein from Mycobacterium tuberculosis (142 aa)%2C FASTA scores: opt: 145%2C E(): 0.00012%2C (22.3%25 identity in 112 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hrp1;locus_tag=Rv2626c;product=Hypoxic response protein 1 Hrp1;protein_id=CCP45424.1;transl_table=11
AL123456.3	EMBL	gene	2953507	2954748	.	-	.	ID=gene-Rv2627c;Name=Rv2627c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2627c
AL123456.3	EMBL	CDS	2953507	2954748	.	-	0	ID=cds-CCP45425.1;Parent=gene-Rv2627c;Dbxref=EnsemblGenomes-Gn:Rv2627c,EnsemblGenomes-Tr:CCP45425,GOA:P9WL67,InterPro:IPR029058,InterPro:IPR029059,NCBI_GP:CCP45425.1;Name=CCP45425.1;Note=Rv2627c%2C (MTCY01A10.05)%2C len: 413 aa. Conserved protein. Some similarity in C-terminal part of O53697|Rv0293c|MTV035.21c hypothetical 44.0 KDA protein from Mycobacterium tuberculosis (400 aa)%2C FASTA scores: opt: 392%2C E(): 1.9e-17%2C (31.1%25 identity in 299 aa overlap). Alternative nucleotide at position 2954439 (T->C%3B R104G) has been observed. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2627c;product=Conserved protein;protein_id=CCP45425.1;transl_table=11
AL123456.3	EMBL	gene	2955058	2955420	.	+	.	ID=gene-Rv2628;Name=Rv2628;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2628
AL123456.3	EMBL	CDS	2955058	2955420	.	+	0	ID=cds-CCP45426.1;Parent=gene-Rv2628;Dbxref=EnsemblGenomes-Gn:Rv2628,EnsemblGenomes-Tr:CCP45426,GOA:P9WL65,NCBI_GP:CCP45426.1;Name=CCP45426.1;Note=Rv2628%2C (MTCY01A10.04c)%2C len: 120 aa. Hypothetical unknown protein. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;gbkey=CDS;locus_tag=Rv2628;product=Hypothetical protein;protein_id=CCP45426.1;transl_table=11
AL123456.3	EMBL	gene	2955767	2956891	.	+	.	ID=gene-Rv2629;Name=Rv2629;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2629
AL123456.3	EMBL	CDS	2955767	2956891	.	+	0	ID=cds-CCP45427.1;Parent=gene-Rv2629;Dbxref=EnsemblGenomes-Gn:Rv2629,EnsemblGenomes-Tr:CCP45427,GOA:P9WL63,InterPro:IPR029064,NCBI_GP:CCP45427.1;Name=CCP45427.1;Note=Rv2629%2C (MTCY01A10.03c)%2C len: 374 aa. Conserved protein%2C similar to Q9ZC00|SC1E6.22c hypothetical 40.7 KDA protein from Streptomyces coelicolor (373 aa)%2C FASTA scores: opt: 425%2C E(): 2.5e-18%2C (30.2%25 identity in 371 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2629;product=Conserved protein;protein_id=CCP45427.1;transl_table=11
AL123456.3	EMBL	gene	2956893	2957432	.	+	.	ID=gene-Rv2630;Name=Rv2630;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2630
AL123456.3	EMBL	CDS	2956893	2957432	.	+	0	ID=cds-CCP45428.1;Parent=gene-Rv2630;Dbxref=EnsemblGenomes-Gn:Rv2630,EnsemblGenomes-Tr:CCP45428,GOA:P9WQ03,InterPro:IPR023572,NCBI_GP:CCP45428.1;Name=CCP45428.1;Note=Rv2630%2C (MTCY01A10.02c)%2C len: 179 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2630;product=Hypothetical protein;protein_id=CCP45428.1;transl_table=11
AL123456.3	EMBL	gene	2957572	2958870	.	+	.	ID=gene-Rv2631;Name=Rv2631;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2631
AL123456.3	EMBL	CDS	2957572	2958870	.	+	0	ID=cds-CCP45429.1;Parent=gene-Rv2631;Dbxref=EnsemblGenomes-Gn:Rv2631,EnsemblGenomes-Tr:CCP45429,GOA:P9WGW5,InterPro:IPR001233,NCBI_GP:CCP45429.1;Name=CCP45429.1;Note=Rv2631%2C (MTCY441.01%2C MTCY01A10.01c)%2C len: 432 aa. Conserved hypothetical protein%2C highly similar to several conserved hypothetical proteins from various species e.g. O29399|AF0862 conserved hypothetical protein from Archaeoglobus fulgidus (482 aa)%2C FASTA scores: opt: 1496%2CE(): 2.1e-80%2C (52.3%25 identity in 432 aa overlap) (has its N-terminus longer 30 aa)%3B O27634|MTH1597 conserved protein from Methanothermobacter thermautotrophicus (488 aa)%2C FASTA scores: opt: 1428%2C E(): 2.1e-76%2C (50.9%25 identity in 432 aa overlap)%3B Q9YB37|APE1758 hypothetical 53.7 KDA protein APE1758 from Aeropyrum pernix (483 aa)%2C FASTA scores: opt: 1422%2C E(): 4.6e-76%2C (49.3%25 identity in 432 aa overlap) (has its N-terminus longer 30 aa)%3B etc. Equivalent to AAK47022 from Mycobacterium tuberculosis strain CDC1551 (432 aa). 3' part extended since first submission (+175 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2631;product=Conserved hypothetical protein;protein_id=CCP45429.1;transl_table=11
AL123456.3	EMBL	gene	2958909	2959190	.	-	.	ID=gene-Rv2632c;Name=Rv2632c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2632c
AL123456.3	EMBL	CDS	2958909	2959190	.	-	0	ID=cds-CCP45430.1;Parent=gene-Rv2632c;Dbxref=EnsemblGenomes-Gn:Rv2632c,EnsemblGenomes-Tr:CCP45430,InterPro:IPR015057,PDB:2FGG,NCBI_GP:CCP45430.1;Name=CCP45430.1;Note=Rv2632c%2C (MTCY441.02c)%2C len: 93 aa. Conserved protein%2C highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis: P71996|YH38_MYCTU|Rv1738|MT1780|MTCY04C12.23 (94 aa)%2C FASTA scores: opt: 319%2C E(): 4.2e-15%2C (53.95%25 identity in 89 aa overlap)%3B and Q9KK61 from Mycobacterium bovis BCG (56 aa)%2CFASTA scores: opt: 178%2C E(): 9.2e-06%2C (52.95%25 identity in 51 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2632c;product=Conserved protein;protein_id=CCP45430.1;transl_table=11
AL123456.3	EMBL	gene	2959335	2959820	.	-	.	ID=gene-Rv2633c;Name=Rv2633c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2633c
AL123456.3	EMBL	CDS	2959335	2959820	.	-	0	ID=cds-CCP45431.1;Parent=gene-Rv2633c;Dbxref=EnsemblGenomes-Gn:Rv2633c,EnsemblGenomes-Tr:CCP45431,InterPro:IPR012312,NCBI_GP:CCP45431.1;Name=CCP45431.1;Note=Rv2633c%2C (MTCY441.03c)%2C len: 161 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2633c;product=Hypothetical protein;protein_id=CCP45431.1;transl_table=11
AL123456.3	EMBL	gene	2960105	2962441	.	-	.	ID=gene-Rv2634c;Name=PE_PGRS46;gbkey=Gene;gene=PE_PGRS46;gene_biotype=protein_coding;locus_tag=Rv2634c
AL123456.3	EMBL	CDS	2960105	2962441	.	-	0	ID=cds-CCP45432.1;Parent=gene-Rv2634c;Dbxref=EnsemblGenomes-Gn:Rv2634c,EnsemblGenomes-Tr:CCP45432,InterPro:IPR000084,NCBI_GP:CCP45432.1;Name=CCP45432.1;Note=Rv2634c%2C (MTCY441.04c)%2C len: 778 aa. PE_PGRS46%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to many e.g. O53553|YZ08_MYCTU|Rv3508|MTV023.15 from Mycobacterium tuberculosis (1901 aa)%2C FASTA scores: opt: 2553%2C E(): 2.2e-93%2C (53.8%25 identity in 866 aa overlap). Equivalent to AAK47026 from Mycobacterium tuberculosis strain CDC1551 (788 aa) but shorter 10 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS46;locus_tag=Rv2634c;product=PE-PGRS family protein PE_PGRS46;protein_id=CCP45432.1;transl_table=11
AL123456.3	EMBL	gene	2962470	2962712	.	+	.	ID=gene-Rv2635;Name=Rv2635;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2635
AL123456.3	EMBL	CDS	2962470	2962712	.	+	0	ID=cds-CCP45433.1;Parent=gene-Rv2635;Dbxref=EnsemblGenomes-Gn:Rv2635,EnsemblGenomes-Tr:CCP45433,NCBI_GP:CCP45433.1;Name=CCP45433.1;Note=Rv2635%2C (MTCY441.05)%2C len: 80 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2635;product=Hypothetical protein;protein_id=CCP45433.1;transl_table=11
AL123456.3	EMBL	gene	2962713	2963390	.	+	.	ID=gene-Rv2636;Name=Rv2636;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2636
AL123456.3	EMBL	CDS	2962713	2963390	.	+	0	ID=cds-CCP45434.1;Parent=gene-Rv2636;Dbxref=EnsemblGenomes-Gn:Rv2636,EnsemblGenomes-Tr:CCP45434,GOA:P9WL55,InterPro:IPR012853,InterPro:IPR027417,NCBI_GP:CCP45434.1;Name=CCP45434.1;Note=Rv2636%2C (MTCY441.06)%2C len: 225 aa. Conserved hypothetical protein%2C showing some similarity with various proteins: Q98FG2|MLL3789 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (239 aa)%2C FASTA scores: opt: 304%2C E(): 3.7e-13%2C (31.55%25 identity in 187 aa overlap)%3B CAC46568|SMC04451 putative chloramphenicol phosphotransferase protein from Rhizobium meliloti (Sinorhizobium meliloti) (220 aa)%2C FASTA scores: opt: 175%2CE(): 0.00014%2C (28.0%25 identity in 225 aa overlap)%3B Q56148|CPT_STRVL chloramphenicol 3-O phosphotransferase from Streptomyces violaceus (Streptomyces venezuelae) (178 aa)%2C FASTA scores: opt: 131%2C E(): 0.1%2C (31.75%25 identity in 170 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Translational start site uncertain%2Cchosen by similarity.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2636;product=Conserved hypothetical protein;protein_id=CCP45434.1;transl_table=11
AL123456.3	EMBL	gene	2963586	2964242	.	+	.	ID=gene-Rv2637;Name=dedA;gbkey=Gene;gene=dedA;gene_biotype=protein_coding;locus_tag=Rv2637
AL123456.3	EMBL	CDS	2963586	2964242	.	+	0	ID=cds-CCP45435.1;Parent=gene-Rv2637;Dbxref=EnsemblGenomes-Gn:Rv2637,EnsemblGenomes-Tr:CCP45435,GOA:P9WP07,InterPro:IPR015414,NCBI_GP:CCP45435.1;Name=CCP45435.1;Note=Rv2637%2C (MTCY441.07)%2C len: 218 aa. Possible dedA%2Ctransmembrane protein%2C equivalent to Q49642|YQ37_MYCLE|ML0467|MLCL581.27|B1177_C2_172/B1177_C1_ 140 hypothetical 23.1 KDA protein (potential integral membrane protein%2C belongs to the DedA family) from Mycobacterium leprae (214 aa)%2C FASTA scores: opt: 1160%2C E(): 4.4e-64%2C(82.75%25 identity in 209 aa overlap)%3B and O69601|Y364_MYCLE|ML0287|MLCB4.30 hypothetical protein (potential integral membrane protein) (222 aa)%2C FASTA scores: opt: 292%2C E(): 6.6e-11%2C (32.25%25 identity in 189 aa overlap). Also highly similar to other membrane proteins e.g. CAC42863|SCBAC36F5.27c putative integral membrane from Streptomyces coelicolor (211 aa)%2C FASTA scores: opt: 837%2CE(): 2.6e-44%2C (59.2%25 identity in 201 aa overlap)%3B Q55705|Y232_SYNY3|SLR0232 potential integral membrane protein from Synechocystis sp. strain PCC 6803 (218 aa)%2CFASTA scores: opt: 415%2C E(): 1.9e-18%2C (37.85%25 identity in 206 aa overlap)%3B Q9RV63|DR1167 DEDA protein from Deinococcus radiodurans (200 aa)%3B P09548|DEDA_ECOLI|B2317|Z3579|ECS3201 DEDA protein (DSG-1 protein) from Escherichia coli strains K12 and O157:H7 (219 aa)%2C blast scores: 178%2C E(): 1.8e-13%2C Identities %3D 53/175 (30%25)%3B etc. Also similar to O06314|Y364_MYCTU|Rv0364|MT0380|MTCY13E10.26 hypothetical 24.5 KDA protein (potential integral membrane protein) from Mycobacterium tuberculosis (227 aa)%2C FASTA scores: opt: 293%2C E(): 5.8e-11%2C (35.85%25 identity in 184 aa overlap). Belongs to the DedA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dedA;locus_tag=Rv2637;product=Possible transmembrane protein DedA;protein_id=CCP45435.1;transl_table=11
AL123456.3	EMBL	gene	2964405	2964851	.	+	.	ID=gene-Rv2638;Name=Rv2638;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2638
AL123456.3	EMBL	CDS	2964405	2964851	.	+	0	ID=cds-CCP45436.1;Parent=gene-Rv2638;Dbxref=EnsemblGenomes-Gn:Rv2638,EnsemblGenomes-Tr:CCP45436,GOA:I6X4W0,InterPro:IPR002645,InterPro:IPR003658,UniProtKB/TrEMBL:I6X4W0,NCBI_GP:CCP45436.1;Name=CCP45436.1;Note=Rv2638%2C (MTCY441.08)%2C len: 148 aa. Conserved hypothetical protein%2C similar in part to Q9WVX8|RSBV_STRCO|bldg|SCH5.12c anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa)%2C FASTA scores: opt: 162%2C E(): 0.00066%2C (31.8%25 identity in 110 aa overlap)%3B and showing weak similarity with various proteins e.g. O69205 hypothetical 13.4 KDA protein from Actinosynnema pretiosum (subsp. auranticum) (128 aa)%2C FASTA scores: opt: 157%2C E(): 0.0016%2C (29.8%25 identity in 114 aa overlap)%3B Q9RJ93|SCF91.32 putative anti-sigma factor antagonist from Streptomyces coelicolor (183 aa)%2C FASTA scores: opt: 148%2C E(): 0.0082%2C (30.85%25 identity in 107 aa overlap)%3B etc. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis: O07728|Rv1904|MTCY180.14c (143 aa)%2C FASTA scores: opt: 456%2C E(): 3.9e-23%2C (52.8%25 identity in 125 aa overlap)%3B and Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128 aa)%2CFASTA scores: opt: 435%2C E(): 8.6e-22%2C (53.6%25 identity in 125 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2638;product=Conserved hypothetical protein;protein_id=CCP45436.1;transl_table=11
AL123456.3	EMBL	gene	2965026	2965358	.	-	.	ID=gene-Rv2639c;Name=Rv2639c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2639c
AL123456.3	EMBL	CDS	2965026	2965358	.	-	0	ID=cds-CCP45437.1;Parent=gene-Rv2639c;Dbxref=EnsemblGenomes-Gn:Rv2639c,EnsemblGenomes-Tr:CCP45437,GOA:P9WFN9,InterPro:IPR003844,NCBI_GP:CCP45437.1;Name=CCP45437.1;Note=Rv2639c%2C (MTCY441.09c)%2C len: 110 aa. Probable conserved integral membrane protein%2C highly similar to many bacterial hypothetical or membrane proteins e.g. Q9X889|YE14_STRCO|SCE15.14 potential integral membrane protein from Streptomyces coelicolor (112 aa)%2C FASTA scores: opt: 597%2C E(): 3.1e-31%2C (73.15%25 identity in 108 aa overlap)%3B Q55939|Y793_SYNY3|SLL0793 potential integral membrane protein from Synechocystis sp. strain PCC 6803 (108 aa)%2C FASTA scores: opt: 341%2C E(): 4.9e-15%2C (51.4%25 identity in 109 aa overlap)%3B O31553|YFJF_BACSU potential integral membrane protein from Bacillus subtilis (109 aa)%2CFASTA scores: opt: 334%2C E(): 1.4e-14%2C (47.5%25 identity in 109 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2639c;product=Probable conserved integral membrane protein;protein_id=CCP45437.1;transl_table=11
AL123456.3	EMBL	gene	2965478	2965837	.	-	.	ID=gene-Rv2640c;Name=Rv2640c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2640c
AL123456.3	EMBL	CDS	2965478	2965837	.	-	0	ID=cds-CCP45438.1;Parent=gene-Rv2640c;Dbxref=EnsemblGenomes-Gn:Rv2640c,EnsemblGenomes-Tr:CCP45438,GOA:I6Y1A7,InterPro:IPR001845,InterPro:IPR011991,UniProtKB/TrEMBL:I6Y1A7,NCBI_GP:CCP45438.1;Name=CCP45438.1;Note=Rv2640c%2C (MTCY441.10c)%2C len: 119 aa. Possible transcriptional regulator%2C arsR family%2C highly similar to many e.g. Q9L1V5|SC4A9.07 putative ArsR-family transcriptional regulator from Streptomyces coelicolor (117 aa)%2C FASTA scores: opt: 261%2C E(): 5.6e-10%2C (47.75%25 identity in 103 aa overlap)%3B Q9X8X8|SCH35.28c putative transcriptional regulator from Streptomyces coelicolor (122 aa)%2C FASTA scores: opt: 252%2C E(): 2.2e-09%2C (37.05%25 identity in 116 aa overlap)%3B Q9L220|SC1A2.21 putative ArsR-family transcriptional from Streptomyces coelicolor (119 aa)%2CFASTA scores: opt: 252%2C E(): 2.2e-09%2C (37.05%25 identity in 116 aa overlap)%3B P77295|YGAV_ECOLI|B2667 hypothetical transcriptional regulator from Escherichia coli strain K12 (99 aa)%2C FASTA scores: opt: 156%2C E(): 0.0023%2C (34.1%25 identity in 88 aa overlap)%3B etc. Also similar to upstream ORF P71941|Rv2642|MTCY441.12 putative transcriptional regulatory protein from Mycobacterium tuberculosis (126 aa)%2C FASTA scores: opt: 237%2C E(): 2e-08%2C (38.55%25 identity in 109 aa overlap). Contains helix-turn-helix motif at aa 59-80 (Score 1166%2C +3.16 SD). Belongs to the ArsR family of transcriptional regulators.;gbkey=CDS;locus_tag=Rv2640c;product=Possible transcriptional regulatory protein (probably ArsR-family);protein_id=CCP45438.1;transl_table=11
AL123456.3	EMBL	gene	2965939	2966397	.	+	.	ID=gene-Rv2641;Name=cadI;gbkey=Gene;gene=cadI;gene_biotype=protein_coding;locus_tag=Rv2641
AL123456.3	EMBL	CDS	2965939	2966397	.	+	0	ID=cds-CCP45439.1;Parent=gene-Rv2641;Dbxref=EnsemblGenomes-Gn:Rv2641,EnsemblGenomes-Tr:CCP45439,GOA:P9WIR5,InterPro:IPR004360,InterPro:IPR029068,NCBI_GP:CCP45439.1;Name=CCP45439.1;Note=Rv2641%2C (MTCY441.11)%2C len: 152 aa. CadI%2C conserved hypothetical protein. Gene induced by cadmium (see Hotter et al.%2C 2001)%2C highly similar to hypothetical proteins e.g. Q9L222|SC1A2.19c from Streptomyces coelicolor (152 aa)%2CFASTA scores: opt: 509%2C E(): 2.3e-27%2C (55.05%25 identity in 149 aa overlap)%3B P45945|YQCK_BACSU from Bacillus subtilis (146 aa)%2C FASTA scores: opt: 295%2C E(): 5.4e-13%2C (33.55%25 identity in 146 aa overlap)%3B and Q98CF8|MLL5167 from Rhizobium loti (Mesorhizobium loti) (124 aa)%2C FASTA scores: opt: 110%2C E(): 1.3%2C (31.4%25 identity in 121 aa overlap). Some similarity with Q10548|Y887_MYCTU|Rv0887c|MT0910|MTCY31.15c from Mycobacterium tuberculosis (152 aa)%2C FASTA scores: opt: 108%2C E(): 2.1%2C (25.7%25 identity in 148 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cadI;locus_tag=Rv2641;product=Cadmium inducible protein CadI;protein_id=CCP45439.1;transl_table=11
AL123456.3	EMBL	gene	2966533	2966913	.	+	.	ID=gene-Rv2642;Name=Rv2642;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2642
AL123456.3	EMBL	CDS	2966533	2966913	.	+	0	ID=cds-CCP45440.1;Parent=gene-Rv2642;Dbxref=EnsemblGenomes-Gn:Rv2642,EnsemblGenomes-Tr:CCP45440,GOA:P71941,InterPro:IPR001845,InterPro:IPR011991,InterPro:IPR018334,UniProtKB/TrEMBL:P71941,NCBI_GP:CCP45440.1;Name=CCP45440.1;Note=Rv2642%2C (MTCY441.12)%2C len: 126 aa. Possible transcriptional regulator%2C arsR family%2C highly similar to many e.g. Q9X8X8|SCH35.28c putative transcriptional regulator from Streptomyces coelicolor (122 aa)%2C FASTA scores: opt: 390%2C E(): 3.7e-19%2C (56.55%25 identity in 122 aa overlap)%3B Q9L220|SC1A2.21 putative ArsR-family transcriptional from Streptomyces coelicolor (119 aa)%2CFASTA scores: opt: 378%2C E(): 2.3e-18%2C (59.8%25 identity in 97 aa overlap)%3B Q9L1V5|SC4A9.07 putative ArsR-family transcriptional regulator from Streptomyces coelicolor (117 aa)%2C FASTA scores: opt: 359%2C E(): 4.1e-17%2C (56.9%25 identity in 116 aa overlap)%3B P52144|ARR2_ECOLI|ARSR from Escherichia coli (117 aa)%2C FASTA scores: opt: 202%2C E(): 1e-06%2C (39.8%25 identity in 88 aa overlap)%3B etc. Also similar to downstream ORF P71939|Rv2640c|MTCY441.10c putative transcriptional regulatory protein from Mycobacterium tuberculosis (119 aa)%2C FASTA scores: opt: 237%2C E(): 5e-09%2C (38.55%25 identity in 109 aa overlap)%3B and others from Mycobacterium tuberculosis e.g. O05840|Rv2358|MTCY27.22c. Contains PS00846 Bacterial regulatory proteins%2C arsR family signature. Contains helix-turn-helix motif at aa 58-79 (Score 1112%2C +2.97 SD). Belongs to the ArsR family of transcriptional regulators.;gbkey=CDS;inference=protein motif:PROSITE:PS00846;locus_tag=Rv2642;product=Possible transcriptional regulatory protein (probably ArsR-family);protein_id=CCP45440.1;transl_table=11
AL123456.3	EMBL	gene	2966910	2968406	.	+	.	ID=gene-Rv2643;Name=arsC;gbkey=Gene;gene=arsC;gene_biotype=protein_coding;locus_tag=Rv2643
AL123456.3	EMBL	CDS	2966910	2968406	.	+	0	ID=cds-CCP45441.1;Parent=gene-Rv2643;Dbxref=EnsemblGenomes-Gn:Rv2643,EnsemblGenomes-Tr:CCP45441,GOA:I6X4W4,InterPro:IPR002657,InterPro:IPR004706,InterPro:IPR023485,UniProtKB/TrEMBL:I6X4W4,NCBI_GP:CCP45441.1;Name=CCP45441.1;Note=Rv2643%2C (MTCY441.13)%2C len: 498 aa. Probable arsC%2Carsenical resistance transport integral membrane protein%2Chighly similar or similar to others e.g. Q9L1X4|SC3D9.05 possible arsenic resistance membrane transport protein from Streptomyces coelicolor (368 aa)%2C FASTA scores: opt: 1729%2CE(): 2.2e-96%2C (74.3%25 identity in 358 aa overlap)%3B Q9X8Y0|SCH35.26 putative heavy metal resistance membrane protein from Streptomyces coelicolor (369 aa)%2C FASTA scores: opt: 1729%2C E(): 2.2e-96%2C (73.8%25 identity in 359 aa overlap)%3B Q06598|ACR3_YEAST|ACR3|YPR201W|P9677.2 arsenical-resistance protein from Saccharomyces cerevisiae (Baker's yeast) (404 aa)%2C FASTA scores: opt: 591%2C E(): 4e-28%2C (36.6%25 identity in 380 aa overlap)%3B etc. Belongs to the ACR3 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=arsC;locus_tag=Rv2643;product=Probable arsenic-transport integral membrane protein ArsC;protein_id=CCP45441.1;transl_table=11
AL123456.3	EMBL	gene	2968533	2968850	.	-	.	ID=gene-Rv2644c;Name=Rv2644c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2644c
AL123456.3	EMBL	CDS	2968533	2968850	.	-	0	ID=cds-CCP45442.1;Parent=gene-Rv2644c;Dbxref=EnsemblGenomes-Gn:Rv2644c,EnsemblGenomes-Tr:CCP45442,GOA:P9WL53,NCBI_GP:CCP45442.1;Name=CCP45442.1;Note=Rv2644c%2C (MTCY441.14c)%2C len: 105 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2644c;product=Hypothetical protein;protein_id=CCP45442.1;transl_table=11
AL123456.3	EMBL	gene	2969497	2969568	.	-	.	ID=gene-valT;Name=valT;gbkey=Gene;gene=valT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2969497	2969568	.	-	.	ID=rna-valT;Parent=gene-valT;Note=codon recognized: GUG%3B valT%2C tRNA-Val%2C anticodon cac%2C length %3D 72;anticodon=(pos:complement(2969534..2969536));gbkey=tRNA;gene=valT;product=tRNA-Val
AL123456.3	EMBL	exon	2969497	2969568	.	-	.	ID=exon-valT-1;Parent=rna-valT;Note=codon recognized: GUG%3B valT%2C tRNA-Val%2C anticodon cac%2C length %3D 72;anticodon=(pos:complement(2969534..2969536));gbkey=tRNA;gene=valT;product=tRNA-Val
AL123456.3	EMBL	gene	2969753	2969825	.	+	.	ID=gene-glyT;Name=glyT;gbkey=Gene;gene=glyT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2969753	2969825	.	+	.	ID=rna-glyT;Parent=gene-glyT;Note=codon recognized: GGC%3B glyT%2C tRNA-Gly%2C anticodon gcc%2C length %3D 73;anticodon=(pos:2969786..2969788);gbkey=tRNA;gene=glyT;product=tRNA-Gly
AL123456.3	EMBL	exon	2969753	2969825	.	+	.	ID=exon-glyT-1;Parent=rna-glyT;Note=codon recognized: GGC%3B glyT%2C tRNA-Gly%2C anticodon gcc%2C length %3D 73;anticodon=(pos:2969786..2969788);gbkey=tRNA;gene=glyT;product=tRNA-Gly
AL123456.3	EMBL	gene	2969855	2969925	.	+	.	ID=gene-cysU;Name=cysU;gbkey=Gene;gene=cysU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2969855	2969925	.	+	.	ID=rna-cysU;Parent=gene-cysU;Note=codon recognized: UGC%3B cysU%2C tRNA-Cys%2C anticodon gca%2C length %3D 71;anticodon=(pos:2969887..2969889);gbkey=tRNA;gene=cysU;product=tRNA-Cys
AL123456.3	EMBL	exon	2969855	2969925	.	+	.	ID=exon-cysU-1;Parent=rna-cysU;Note=codon recognized: UGC%3B cysU%2C tRNA-Cys%2C anticodon gca%2C length %3D 71;anticodon=(pos:2969887..2969889);gbkey=tRNA;gene=cysU;product=tRNA-Cys
AL123456.3	EMBL	gene	2969942	2970013	.	+	.	ID=gene-valU;Name=valU;gbkey=Gene;gene=valU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	2969942	2970013	.	+	.	ID=rna-valU;Parent=gene-valU;Note=codon recognized: GUC%3B valU%2C tRNA-Val%2C anticodon gac%2C length %3D 72;anticodon=(pos:2969974..2969976);gbkey=tRNA;gene=valU;product=tRNA-Val
AL123456.3	EMBL	exon	2969942	2970013	.	+	.	ID=exon-valU-1;Parent=rna-valU;Note=codon recognized: GUC%3B valU%2C tRNA-Val%2C anticodon gac%2C length %3D 72;anticodon=(pos:2969974..2969976);gbkey=tRNA;gene=valU;product=tRNA-Val
AL123456.3	EMBL	gene	2970123	2970554	.	+	.	ID=gene-Rv2645;Name=Rv2645;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2645
AL123456.3	EMBL	CDS	2970123	2970554	.	+	0	ID=cds-CCP45443.1;Parent=gene-Rv2645;Dbxref=EnsemblGenomes-Gn:Rv2645,EnsemblGenomes-Tr:CCP45443,NCBI_GP:CCP45443.1;Name=CCP45443.1;Note=Rv2645%2C (MTCY441.15)%2C len: 143 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2645;product=Hypothetical protein;protein_id=CCP45443.1;transl_table=11
AL123456.3	EMBL	gene	2970551	2971549	.	+	.	ID=gene-Rv2646;Name=Rv2646;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2646
AL123456.3	EMBL	CDS	2970551	2971549	.	+	0	ID=cds-CCP45444.1;Parent=gene-Rv2646;Dbxref=EnsemblGenomes-Gn:Rv2646,EnsemblGenomes-Tr:CCP45444,GOA:I6XEU5,InterPro:IPR002104,InterPro:IPR011010,InterPro:IPR013762,UniProtKB/TrEMBL:I6XEU5,NCBI_GP:CCP45444.1;Name=CCP45444.1;Note=Rv2646%2C (MTCY441.16)%2C len: 332 aa. Probable integrase%2C similar to others e.g. P06723|VINT_BP186|int integrase from Bacteriophage 186 (336 aa)s FASTA scores: opt: 198%2C E(): 6.3e-05%2C (30.45%25 identity in 138 aa overlap). Could be belong to the 'phage' integrase family.;gbkey=CDS;locus_tag=Rv2646;product=Probable integrase;protein_id=CCP45444.1;transl_table=11
AL123456.3	EMBL	gene	2971659	2972027	.	+	.	ID=gene-Rv2647;Name=Rv2647;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2647
AL123456.3	EMBL	CDS	2971659	2972027	.	+	0	ID=cds-CCP45445.1;Parent=gene-Rv2647;Dbxref=EnsemblGenomes-Gn:Rv2647,EnsemblGenomes-Tr:CCP45445,UniProtKB/TrEMBL:I6YDZ2,NCBI_GP:CCP45445.1;Name=CCP45445.1;Note=Rv2647%2C (MTCY441.17)%2C len: 122 aa (questionable ORF). Hypothetical protein%2C probably corresponds to conserved DNA sequence also found in MTCY336.29c and Rv1574|MTCY336.30c|O06616 hypothetical 11.4 KDA protein from Mycobacterium tuberculosis (103 aa)%2C FASTA scores: opt: 170%2C E(): 0.0002%2C (69.05%25 identity in 42 aa overlap). Shows weak similarity with Q9EUM1|RESB resolvase protein homolog from Corynebacterium glutamicum (Brevibacterium flavum) (343 aa)%2C FASTA scores: opt: 112%2C E(): 2.9%2C (31.05%25 identity in 87 aa overlap).;gbkey=CDS;locus_tag=Rv2647;product=Hypothetical protein;protein_id=CCP45445.1;transl_table=11
AL123456.3	EMBL	repeat_region	2972106	2972108	.	+	.	ID=id-AL123456.3:2972106..2972108;Note=3 bp direct repeat: TCG at 5'-end of IS6110;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	2972109	2973463	.	+	.	ID=id-AL123456.3:2972109..2973463;Note=IS6110-10%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-10
AL123456.3	EMBL	repeat_region	2972109	2972136	.	+	.	ID=id-AL123456.3:2972109..2972136;Note=28 bp inverted repeat: TGAACCGCCCCGGCATGTCCGGAGACTC at the left end of IS6110;gbkey=repeat_region
AL123456.3	EMBL	gene	2972160	2972486	.	+	.	ID=gene-Rv2648;Name=Rv2648;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2648
AL123456.3	EMBL	CDS	2972160	2972486	.	+	0	ID=cds-CCP45446.1;Parent=gene-Rv2648;Dbxref=EnsemblGenomes-Gn:Rv2648,EnsemblGenomes-Tr:CCP45446,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP45446.1;Name=CCP45446.1;Note=Rv2648%2C (MTCY441.17A)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2648 and Rv2649%2Cthe sequence UUUUAAAG (directly upstream of Rv2649) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv2648;product=Probable transposase for insertion sequence element IS6110 (fragment);protein_id=CCP45446.1;transl_table=11
AL123456.3	EMBL	gene	2972435	2973421	.	+	.	ID=gene-Rv2649;Name=Rv2649;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2649;partial=true;start_range=.,2972435
AL123456.3	EMBL	CDS	2972435	2973421	.	+	0	ID=cds-CCP45447.1;Parent=gene-Rv2649;Dbxref=EnsemblGenomes-Gn:Rv2649,EnsemblGenomes-Tr:CCP45447,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP45447.1;Name=CCP45447.1;Note=Rv2649%2C (MTCY441.18)%2C len: 328 aa. Probable transposase for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2648 and Rv2649%2C the sequence UUUUAAAG (directly upstream of Rv2649) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv2649;partial=true;product=Probable transposase for insertion sequence element IS6110;protein_id=CCP45447.1;start_range=.,2972435;transl_table=11
AL123456.3	EMBL	repeat_region	2973436	2973463	.	-	.	ID=id-AL123456.3:2973436..2973463;Note=28 bp inverted repeat%2C TGAACCGCCCCGGTGAGTCCGGAGACTC%2Cat the right end of IS6110.;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2973464	2973466	.	+	.	ID=id-AL123456.3:2973464..2973466;Note=3 bp direct repeat: TCG at 3'-end of IS6110;gbkey=repeat_region
AL123456.3	EMBL	gene	2973795	2975234	.	-	.	ID=gene-Rv2650c;Name=Rv2650c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2650c
AL123456.3	EMBL	CDS	2973795	2975234	.	-	0	ID=cds-CCP45448.1;Parent=gene-Rv2650c;Dbxref=EnsemblGenomes-Gn:Rv2650c,EnsemblGenomes-Tr:CCP45448,GOA:P71947,InterPro:IPR006444,InterPro:IPR024455,UniProtKB/TrEMBL:P71947,NCBI_GP:CCP45448.1;Name=CCP45448.1;Note=Rv2650c%2C (MTCY441.19)%2C len: 479 aa. Possible phiRv2 prophage protein (capsid subunit) (see citation below)%2Chighly similar to O06614|Rv1576c|MTCY336.28 probable phiRv1 phage protein from Mycobacterium tuberculosis (473 aa)%2CFASTA scores: opt: 2782%2C E(): 2.8e-159%2C (89.1%25 identity in 468 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2650c;product=Possible PhiRv2 prophage protein;protein_id=CCP45448.1;transl_table=11
AL123456.3	EMBL	gene	2975242	2975775	.	-	.	ID=gene-Rv2651c;Name=Rv2651c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2651c
AL123456.3	EMBL	CDS	2975242	2975775	.	-	0	ID=cds-CCP45449.1;Parent=gene-Rv2651c;Dbxref=EnsemblGenomes-Gn:Rv2651c,EnsemblGenomes-Tr:CCP45449,GOA:I6XEX3,InterPro:IPR006433,UniProtKB/TrEMBL:I6XEX3,NCBI_GP:CCP45449.1;Name=CCP45449.1;Note=Rv2651c%2C (MTCY441.20c)%2C len: 177 aa. Possible protease protein%2C phiRv2 phage protein (prohead protease) (see citation below)%2C showing some similarity with several proteases e.g. Q9A4P4|CC2786 putative protease from Caulobacter crescentus (138 aa)%2C FASTA scores: opt: 206%2CE(): 2e-06%2C (36.35%25 identity in 132 aa overlap)%3B Q9RNH0 putative prohead protease from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (184 aa)%2C FASTA scores: opt: 196%2C E(): 1.1e-05%2C (35.05%25 identity in 137 aa overlap)%3B BAB35014|ECS1591 putative prohead protease from Escherichia coli strain O157:H7 (185 aa)%2C FASTA scores: opt: 187%2C E(): 4.1e-05%2C (32.9%25 identity in 158 aa overlap)%3B etc. And highly similar to O06613|Rv1577c|MTCY336.27 Probable phiRV1 phage protein from Mycobacterium tuberculosis (170 aa)%2CFASTA scores: opt: 987%2C E(): 2.3e-56%2C (89.35%25 identity in 169 aa overlap).;gbkey=CDS;locus_tag=Rv2651c;product=Possible PhiRv2 prophage protease;protein_id=CCP45449.1;transl_table=11
AL123456.3	EMBL	gene	2975928	2976554	.	-	.	ID=gene-Rv2652c;Name=Rv2652c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2652c
AL123456.3	EMBL	CDS	2975928	2976554	.	-	0	ID=cds-CCP45450.1;Parent=gene-Rv2652c;Dbxref=EnsemblGenomes-Gn:Rv2652c,EnsemblGenomes-Tr:CCP45450,InterPro:IPR006448,UniProtKB/TrEMBL:P71949,NCBI_GP:CCP45450.1;Name=CCP45450.1;Note=Rv2652c%2C (MTCY441.21c)%2C len: 208 aa. Probable phiRv2 phage protein (terminase) (see citation below)%2C showing some similarity with AAK79859|Q97HW1|CAC1896 phage terminase-like protein (small subunit) from Clostridium acetobutylicum (151 aa)%2C FASTA scores: opt: 155%2C E(): 0.012%2C (24.7%25 identity in 158 aa overlap)%3B and Q9B019 hypothetical 17.8 KDA protein from Bacteriophage GMSE-1 (159 aa)%2C FASTA scores: opt: 141%2C E(): 0.087%2C (27.65%25 identity in 159 aa overlap). Also highly similar to O06612|Rv1578c|MTCY336.26 Probable phiRV1 phage protein from Mycobacterium tuberculosis (156 aa)%2C FASTA scores: opt: 448%2C E(): 1.2e-20%2C (48.1%25 identity in 156 aa overlap). Equivalent to AAK47043 from Mycobacterium tuberculosis strain CDC1551 but longer 45 aa.;gbkey=CDS;locus_tag=Rv2652c;product=Probable PhiRv2 prophage protein;protein_id=CCP45450.1;transl_table=11
AL123456.3	EMBL	gene	2976586	2976909	.	-	.	ID=gene-Rv2653c;Name=Rv2653c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2653c
AL123456.3	EMBL	CDS	2976586	2976909	.	-	0	ID=cds-CCP45451.1;Parent=gene-Rv2653c;Dbxref=EnsemblGenomes-Gn:Rv2653c,EnsemblGenomes-Tr:CCP45451,GOA:P9WJ13,NCBI_GP:CCP45451.1;Name=CCP45451.1;Note=Rv2653c%2C (MTCY441.22c)%2C len: 107 aa. Hypothetical unknown protein%2C possibly phiRv2 phage protein (see citation below).;gbkey=CDS;locus_tag=Rv2653c;product=Possible PhiRv2 prophage protein;protein_id=CCP45451.1;transl_table=11
AL123456.3	EMBL	gene	2976989	2977234	.	-	.	ID=gene-Rv2654c;Name=Rv2654c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2654c
AL123456.3	EMBL	CDS	2976989	2977234	.	-	0	ID=cds-CCP45452.1;Parent=gene-Rv2654c;Dbxref=EnsemblGenomes-Gn:Rv2654c,EnsemblGenomes-Tr:CCP45452,GOA:P9WJ11,NCBI_GP:CCP45452.1;Name=CCP45452.1;Note=Rv2654c%2C (MTCY441.23c)%2C len: 81 aa. Hypothetical ala-rich protein%2C possibly phiRv2 phage protein (see citation below)%2C similar to C-terminus of Q9HNI3|VNG2091H hypothetical protein from Halobacterium sp. strain NRC-1 (212 aa)%2C FASTA scores: opt: 122%2C E(): 0.46%2C (43.05%25 identity in 79 aa overlap).;gbkey=CDS;locus_tag=Rv2654c;product=Possible PhiRv2 prophage protein;protein_id=CCP45452.1;transl_table=11
AL123456.3	EMBL	gene	2977231	2978658	.	-	.	ID=gene-Rv2655c;Name=Rv2655c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2655c
AL123456.3	EMBL	CDS	2977231	2978658	.	-	0	ID=cds-CCP45453.1;Parent=gene-Rv2655c;Dbxref=EnsemblGenomes-Gn:Rv2655c,EnsemblGenomes-Tr:CCP45453,InterPro:IPR022081,UniProtKB/TrEMBL:I6Y1F0,NCBI_GP:CCP45453.1;Name=CCP45453.1;Note=Rv2655c%2C (MTCY441.24c)%2C len: 475 aa. Hypothetical protein%2C possibly phiRv2 phage protein (putative primase-like protein) (see citation below). C-terminus similar to P22875|YXIS_SACER hypothetical 28.9 KDA protein (probably does not play a direct role in plasmid integration or excision) from Saccharopolyspora erythraea (Streptomyces erythraeus) plasmid pSE211 (263 aa)%2C FASTA scores: opt: 389%2C E(): 2.7e-15%2C (33.45%25 identity in 269 aa overlap). Weak similarity in N-terminus to O06608|MTCY336.22|Rv1582c Probable phiRV1 phage protein from Mycobacterium tuberculosis (471 aa)%2C FASTA scores: opt: 133%2C E(): 2.5%2C (36.0%25 identity in 75 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2655c;product=Possible PhiRv2 prophage protein;protein_id=CCP45453.1;transl_table=11
AL123456.3	EMBL	gene	2978660	2979052	.	-	.	ID=gene-Rv2656c;Name=Rv2656c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2656c
AL123456.3	EMBL	CDS	2978660	2979052	.	-	0	ID=cds-CCP45454.1;Parent=gene-Rv2656c;Dbxref=EnsemblGenomes-Gn:Rv2656c,EnsemblGenomes-Tr:CCP45454,InterPro:IPR024384,NCBI_GP:CCP45454.1;Name=CCP45454.1;Note=Rv2656c%2C (MTCY441.25c)%2C len: 130 aa. Probable phiRv2 phage protein (see Hatfull 2000)%2C highly similar to O06607|YF83_MYCTU|Rv1583c|MT3573.2|MTCY336.21 Probable phiRV1 phage protein from Mycobacterium tuberculosis (132 aa)%2C FASTA scores: opt: 734%2C E(): 2.5e-39%2C (81.5%25 identity in 131 aa overlap)%3B and some similarity with Q982T4|MLL8506 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (204 aa)%2C FASTA scores: opt: 104%2C E(): 9.7%2C (31.85%25 identity in 113 aa overlap).;gbkey=CDS;locus_tag=Rv2656c;product=Possible PhiRv2 prophage protein;protein_id=CCP45454.1;transl_table=11
AL123456.3	EMBL	gene	2979049	2979309	.	-	.	ID=gene-Rv2657c;Name=Rv2657c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2657c
AL123456.3	EMBL	CDS	2979049	2979309	.	-	0	ID=cds-CCP45455.1;Parent=gene-Rv2657c;Dbxref=EnsemblGenomes-Gn:Rv2657c,EnsemblGenomes-Tr:CCP45455,GOA:I6YE30,InterPro:IPR009061,InterPro:IPR010093,UniProtKB/TrEMBL:I6YE30,NCBI_GP:CCP45455.1;Name=CCP45455.1;Note=Rv2657c%2C (MTCY441.26c)%2C len: 86 aa. Probable phiRv2 phage protein (excisionase) (see citation below)%2C similar to O22001|VG36_BPMD2|36|G2 gene 36 protein (GP36) from Mycobacteriophage D29 (56 aa)%2C FASTA scores: opt: 171%2C E(): 9.6e-06%2C (48.0%25 identity in 50 aa overlap)%3B and Q05246|VG36_BPML5|36 gene 36 protein (GP36) from Mycobacteriophage L5 (56 aa)%2C FASTA scores: opt: 169%2C E(): 1.3e-05%2C (50%25 identity in 50 aa overlap). Similarity suggests alternative start at 21737. Contains possible helix-turn-helix motif from aa 33 to 54 (Score 1655%2C +4.82 SD).;gbkey=CDS;locus_tag=Rv2657c;product=Probable PhiRv2 prophage protein;protein_id=CCP45455.1;transl_table=11
AL123456.3	EMBL	gene	2979326	2979688	.	-	.	ID=gene-Rv2658c;Name=Rv2658c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2658c
AL123456.3	EMBL	CDS	2979326	2979688	.	-	0	ID=cds-CCP45456.1;Parent=gene-Rv2658c;Dbxref=EnsemblGenomes-Gn:Rv2658c,EnsemblGenomes-Tr:CCP45456,NCBI_GP:CCP45456.1;Name=CCP45456.1;Note=Rv2658c%2C (MTCY441.27c)%2C len: 120 aa. Hypothetical unknown protein%2C probably phage protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2658c;product=Possible prophage protein;protein_id=CCP45456.1;transl_table=11
AL123456.3	EMBL	gene	2979691	2980818	.	-	.	ID=gene-Rv2659c;Name=Rv2659c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2659c
AL123456.3	EMBL	CDS	2979691	2980818	.	-	0	ID=cds-CCP45457.1;Parent=gene-Rv2659c;Dbxref=EnsemblGenomes-Gn:Rv2659c,EnsemblGenomes-Tr:CCP45457,GOA:P9WMB3,InterPro:IPR002104,InterPro:IPR004107,InterPro:IPR011010,InterPro:IPR013762,InterPro:IPR023109,NCBI_GP:CCP45457.1;Name=CCP45457.1;Note=Rv2659c%2C (MTCY441.28c)%2C len: 375 aa. Probable integrase%2C phiRv2 phage protein: putative member of the phage integrase family of tyrosine recombinases (see Hatfull 2000)%2C highly similar to others e.g. P22884|VINT_BPML5|33|int from Mycobacteriophage L5 (371 aa)%2C FASTA scores: opt: 836%2C E(): 1.2e-44%2C (39.0%25 identity in 372 aa overlap)%3B Q38361|VINT_BPMD2|33|int from Mycobacteriophage D29 (333 aa)%2C FASTA scores: opt: 786%2CE(): 1.4e-41%2C (40.55%25 identity in 338 aa overlap)%3B etc. Seems belongs to the 'phage' integrase family.;gbkey=CDS;locus_tag=Rv2659c;product=Probable PhiRv2 prophage integrase;protein_id=CCP45457.1;transl_table=11
AL123456.3	EMBL	gene	2980963	2981190	.	-	.	ID=gene-Rv2660c;Name=Rv2660c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2660c
AL123456.3	EMBL	CDS	2980963	2981190	.	-	0	ID=cds-CCP45458.1;Parent=gene-Rv2660c;Dbxref=EnsemblGenomes-Gn:Rv2660c,EnsemblGenomes-Tr:CCP45458,UniProtKB/TrEMBL:I6Y1F5,NCBI_GP:CCP45458.1;Name=CCP45458.1;Note=Rv2660c%2C (MTCY441.29c)%2C len: 75 aa (questionable orf). Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2660c;product=Hypothetical protein;protein_id=CCP45458.1;transl_table=11
AL123456.3	EMBL	gene	2981187	2981576	.	-	.	ID=gene-Rv2661c;Name=Rv2661c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2661c
AL123456.3	EMBL	CDS	2981187	2981576	.	-	0	ID=cds-CCP45459.1;Parent=gene-Rv2661c;Dbxref=EnsemblGenomes-Gn:Rv2661c,EnsemblGenomes-Tr:CCP45459,UniProtKB/TrEMBL:P71958,NCBI_GP:CCP45459.1;Name=CCP45459.1;Note=Rv2661c%2C (MTCY441.30c)%2C len: 129 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2661c;product=Hypothetical protein;protein_id=CCP45459.1;transl_table=11
AL123456.3	EMBL	gene	2981482	2981754	.	+	.	ID=gene-Rv2662;Name=Rv2662;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2662
AL123456.3	EMBL	CDS	2981482	2981754	.	+	0	ID=cds-CCP45460.1;Parent=gene-Rv2662;Dbxref=EnsemblGenomes-Gn:Rv2662,EnsemblGenomes-Tr:CCP45460,UniProtKB/TrEMBL:P71959,NCBI_GP:CCP45460.1;Name=CCP45460.1;Note=Rv2662%2C (MTCY441.31)%2C len: 90 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2662;product=Hypothetical protein;protein_id=CCP45460.1;transl_table=11
AL123456.3	EMBL	gene	2981853	2982086	.	+	.	ID=gene-Rv2663;Name=Rv2663;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2663
AL123456.3	EMBL	CDS	2981853	2982086	.	+	0	ID=cds-CCP45461.1;Parent=gene-Rv2663;Dbxref=EnsemblGenomes-Gn:Rv2663,EnsemblGenomes-Tr:CCP45461,UniProtKB/TrEMBL:I6X520,NCBI_GP:CCP45461.1;Name=CCP45461.1;Note=Rv2663%2C (MTCY441.32)%2C len: 77 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2663;product=Hypothetical protein;protein_id=CCP45461.1;transl_table=11
AL123456.3	EMBL	gene	2982097	2982351	.	+	.	ID=gene-Rv2664;Name=Rv2664;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2664
AL123456.3	EMBL	CDS	2982097	2982351	.	+	0	ID=cds-CCP45462.1;Parent=gene-Rv2664;Dbxref=EnsemblGenomes-Gn:Rv2664,EnsemblGenomes-Tr:CCP45462,UniProtKB/TrEMBL:I6Y9Z5,NCBI_GP:CCP45462.1;Name=CCP45462.1;Note=Rv2664%2C (MTCY441.33)%2C len: 84 aa. Hypothetical protein. Some weak similarity to nearby P71964|Rv2667|clpX'|MT2741|MTCY441.36 possible ATP-dependent protease ATP-binding subunit from Mycobacterium tuberculosis (252 aa)%2C FASTA scores: opt: 134%2C E(): 0.027%2C (31.15%25 identity in 77 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2664;product=Hypothetical protein;protein_id=CCP45462.1;transl_table=11
AL123456.3	EMBL	gene	2982699	2982980	.	+	.	ID=gene-Rv2665;Name=Rv2665;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2665
AL123456.3	EMBL	CDS	2982699	2982980	.	+	0	ID=cds-CCP45463.1;Parent=gene-Rv2665;Dbxref=EnsemblGenomes-Gn:Rv2665,EnsemblGenomes-Tr:CCP45463,UniProtKB/TrEMBL:I6Y1F9,NCBI_GP:CCP45463.1;Name=CCP45463.1;Note=Rv2665%2C (MTCY441.34)%2C len: 93 aa. Hypothetical arg-rich protein%2C showing some similarity to N-terminus of P71640|Rv2811|MTCY16B7.32c hypothetical 21.1 KDA protein from Mycobacterium tuberculosis (202 aa)%2C FASTA scores: opt: 157%2C E(): 0.0011%2C (37.5%25 identity in 72 aa overlap)%3B and also to part of O35132|CP2B_RAT|CYP27B1|CYP27B 25-hydroxyvitamin D-1 alpha hydroxylase%2C mitochondrial precursor from Rattus norvegicus (Rat) (501 aa)%2C FASTA scores: opt: 106%2C E(): 5.4%2C (34.5%25 identity in 87 aa overlap).;gbkey=CDS;locus_tag=Rv2665;product=Hypothetical arginine rich protein;protein_id=CCP45463.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	2982946	2983854	.	+	.	ID=id-AL123456.3:2982946..2983854;Note=IS1081'-4%2C len: 909 nt. Defective Insertion sequence IS1081 element%3B truncated at 3'-end.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1081'-4
AL123456.3	EMBL	repeat_region	2983019	2983033	.	+	.	ID=id-AL123456.3:2983019..2983033;Note=15 bp Inverted repeat at the left end of IS1081:TCGCGTGATCCTTCG%2C right end copy is missing;gbkey=repeat_region
AL123456.3	EMBL	gene	2983071	2983874	.	+	.	ID=gene-Rv2666;Name=Rv2666;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2666
AL123456.3	EMBL	CDS	2983071	2983874	.	+	0	ID=cds-CCP45464.1;Parent=gene-Rv2666;Dbxref=EnsemblGenomes-Gn:Rv2666,EnsemblGenomes-Tr:CCP45464,GOA:P71963,InterPro:IPR001207,UniProtKB/TrEMBL:P71963,NCBI_GP:CCP45464.1;Name=CCP45464.1;Note=Rv2666%2C (MTCY441.35)%2C len: 267 aa. Probable transposase (fragment)%2C identical in region of overlap to P35882|TRA1_MYCBO|TRA1_MYCTU transposase for insertion sequence element IS1081 from Mycobacterium tuberculosis or bovis (415 aa). Last 4 codons not part of gene. Contains PS01007 Transposases%2C Mutator family%2C signature.;gbkey=CDS;inference=protein motif:PROSITE:PS01007;locus_tag=Rv2666;product=Probable transposase for insertion sequence element IS1081 (fragment);protein_id=CCP45464.1;transl_table=11
AL123456.3	EMBL	gene	2983896	2984654	.	+	.	ID=gene-Rv2667;Name=clpC2;gbkey=Gene;gene=clpC2;gene_biotype=protein_coding;gene_synonym=clpX';locus_tag=Rv2667
AL123456.3	EMBL	CDS	2983896	2984654	.	+	0	ID=cds-CCP45465.1;Parent=gene-Rv2667;Dbxref=EnsemblGenomes-Gn:Rv2667,EnsemblGenomes-Tr:CCP45465,GOA:P9WPC7,InterPro:IPR004176,InterPro:IPR023150,NCBI_GP:CCP45465.1;Name=CCP45465.1;Note=Rv2667%2C (MTCY441.36)%2C len: 252 aa. Possible clpC2%2CATP-dependent protease atp-binding subunit%2C highly similar to Q9X8L2|SCE9.40 hypothetical 27.3 KDA protein from Streptomyces coelicolor (258 aa)%2C FASTA scores: opt: 877%2CE(): 2.2e-46%2C (57.25%25 identity in 255 aa overlap). The second half of the protein is highly similar to N-terminal of several CLP-family proteins e.g. P24428|CLPC_MYCLE|ML0235 probable ATP-dependent CLP protease ATP-binding subunit from Mycobacterium leprae (848 aa)%2C FASTA scores: opt: 307%2C E(): 3.2e-11%2C (38.6%25 identity in 158 aa overlap)%3B O06286|CLPC_MYCTU|Rv3596c|MT3703|MTCY07H7B.26 probable ATP-dependent CLP protease ATP-binding subunit from Mycobacterium tuberculosis (848 aa)%2C FASTA scores: opt: 307%2C E(): 3.2e-11%2C (38.6%25 identity in 158 aa overlap)%3B Q9S6T8|SCE94.24c putative CLP-family ATP-binding protease from Streptomyces coelicolor (841 aa)%2C FASTA scores: opt: 303%2C E(): 5.6e-11%2C (38.8%25 identity in 152 aa overlap)%3B etc. Some weak similarity to nearby P71961|MTCY441.33|Rv2664 hypothetical protein from Mycobacterium tuberculosis (83 aa). Contain Pfam match to entry PF02861 Clp amino terminal domain. Belongs to the CLPA/CLPB family. CLPC subfamily. Note that previously known as clpX';experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=clpC2;locus_tag=Rv2667;product=Possible ATP-dependent protease ATP-binding subunit ClpC2;protein_id=CCP45465.1;transl_table=11
AL123456.3	EMBL	gene	2984733	2985254	.	+	.	ID=gene-Rv2668;Name=Rv2668;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2668
AL123456.3	EMBL	CDS	2984733	2985254	.	+	0	ID=cds-CCP45466.1;Parent=gene-Rv2668;Dbxref=EnsemblGenomes-Gn:Rv2668,EnsemblGenomes-Tr:CCP45466,UniProtKB/TrEMBL:P71965,NCBI_GP:CCP45466.1;Name=CCP45466.1;Note=Rv2668%2C (MTCY441.37)%2C len: 173 aa. Hypothetical ala-%2C val-rich protein%2C possibly exported. Equivalent to AAK47057 from Mycobacterium tuberculosis strain CDC1551 (208 aa) but N-terminal part shorter 35 aa and with few differences. Has potential signal peptide sequence. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2668;product=Possible exported alanine and valine rich protein;protein_id=CCP45466.1;transl_table=11
AL123456.3	EMBL	gene	2985283	2985753	.	+	.	ID=gene-Rv2669;Name=Rv2669;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2669
AL123456.3	EMBL	CDS	2985283	2985753	.	+	0	ID=cds-CCP45467.1;Parent=gene-Rv2669;Dbxref=EnsemblGenomes-Gn:Rv2669,EnsemblGenomes-Tr:CCP45467,GOA:P9WQG5,InterPro:IPR000182,InterPro:IPR016181,NCBI_GP:CCP45467.1;Name=CCP45467.1;Note=Rv2669%2C (MTCY441.38)%2C len: 156 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Similarity to several proteins e.g. Q9A6M0|CC2073 acetyltransferase (GNAT family) from Caulobacter crescentus (178 aa)%2C FASTA scores: opt: 242%2C E(): 1.2e-09%2C (30.9%25 identity in 165 aa overlap)%3B Q99RQ8|SA2159 hypothetical protein similar to transcription repressor of sporulation%2Cseptation and degradation paiA from Staphylococcus aureus subsp. aureus N315 (171 aa)%2C FASTA scores: opt: 214%2C E(): 9.8e-08%2C (27.5%25 identity in 160 aa overlap)%3B BAB58531|SAV2369 hypothetical 20.1 KDA protein from Staphylococcus aureus subsp. aureus Mu50 (171 aa)%2C FASTA scores: opt: 214%2C E(): 9.8e-08%2C (27.5%25 identity in 160 aa overlap)%3B P21340|PAIA_BACSU|O32112 protease synthase and sporulation from Bacillus subtilis (171 aa)%2C FASTA scores: opt: 209%2C E(): 2.1e-07%2C (22.85%25 identity in 162 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2669;product=GCN5-related N-acetyltransferase;protein_id=CCP45467.1;transl_table=11
AL123456.3	EMBL	gene	2985731	2986840	.	-	.	ID=gene-Rv2670c;Name=Rv2670c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2670c
AL123456.3	EMBL	CDS	2985731	2986840	.	-	0	ID=cds-CCP45468.1;Parent=gene-Rv2670c;Dbxref=EnsemblGenomes-Gn:Rv2670c,EnsemblGenomes-Tr:CCP45468,GOA:I6Y1G3,InterPro:IPR005654,InterPro:IPR027417,UniProtKB/TrEMBL:I6Y1G3,NCBI_GP:CCP45468.1;Name=CCP45468.1;Note=Rv2670c%2C (MTCY441.39c)%2C len: 369 aa. Conserved hypothetical protein%2C equivalent%2C but longer 164 aa%2C to O05683|MLC1351.22c hypothetical 17.3 KDA protein from Mycobacterium leprae (160 aa)%2C FASTA scores: opt: 847%2C E(): 1.2e-45%2C (82.4%25 identity in 159 aa overlap). And highly similar to Q9X824|SC9B1.04c putative ATP/GTP-binding integral membrane protein from Streptomyces coelicolor (350 aa)%2C FASTA scores: opt: 1169%2C E(): 2e-65%2C (56.85%25 identity in 343 aa overlap)%3B and Q9RWB0|DR0759 conserved hypothetical protein from Deinococcus radiodurans (351 aa)%2CFASTA scores: opt: 859%2C E(): 4e-46%2C (45.9%25 identity in 331 aa overlap). Also some similarity with other proteins e.g. P46442|YHCM_ECOLI|AAG58360|BAB37528 hypothetical protein from Escherichia coli strains K12 and O157:H7 (375 aa)%2CFASTA scores: opt: 237%2C E(): 2.1e-07%2C (28.0%25 identity in 325 aa overlap)%3B Q9JRK2|NMA1520|NMB1306 putative nucleotide-binding protein from Neisseria meningitidis (serogroup a and B) (383 aa)%2C FASTA scores: opt: 221%2C E(): 2.1e-06%2C (27.8%25 identity in 356 aa overlap)%3B Q9HVX7|PA4438 hypothetical protein from Pseudomonas aeruginosa (364 aa)%2CFASTA scores: opt: 211%2C E(): 8.5e-06%2C (28.9%25 identity in 353 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2670c;product=Conserved hypothetical protein;protein_id=CCP45468.1;transl_table=11
AL123456.3	EMBL	gene	2986839	2987615	.	+	.	ID=gene-Rv2671;Name=ribD;gbkey=Gene;gene=ribD;gene_biotype=protein_coding;gene_synonym=ribG;locus_tag=Rv2671
AL123456.3	EMBL	CDS	2986839	2987615	.	+	0	ID=cds-CCP45469.1;Parent=gene-Rv2671;Dbxref=EnsemblGenomes-Gn:Rv2671,EnsemblGenomes-Tr:CCP45469,GOA:P71968,InterPro:IPR002734,InterPro:IPR024072,UniProtKB/TrEMBL:P71968,NCBI_GP:CCP45469.1;Name=CCP45469.1;Note=Rv2671%2C (MTCY441.40)%2C len: 258 aa. Possible ribD (alternate gene name: ribG)%2C bifunctional riboflavin biosynthesis protein incuding diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase%2C highly similar to O05684|MLC1351.23|ML1340 possible reductase from Mycobacterium leprae (268 aa)%2C FASTA scores: opt: 1211%2CE(): 3e-68%2C (72.9%25 identity in 251 aa overlap). Also weakly similar to others e.g. Q9HWX2|RIBD|PA4056 riboflavin-specific deaminase/reductase from Pseudomonas aeruginosa (373 aa)%2C FASTA scores: opt: 211%2C E(): 6.3e-06%2C(30.1%25 identity in 216 aa overlap)%3B Q9HQA1|RIBG|VNG1256G riboflavin-specific deaminase from Halobacterium sp. strain NRC-1 (220 aa)%2C FASTA scores: opt: 202%2C E(): 1.5e-05%2C(27.0%25 identity in 174 aa overlap)%3B O28272|RIB7_ARCFU|AF2007 putative 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase) from Archaeoglobus fulgidus (219 aa)%2C FASTA scores: opt: 209%2C E(): 5.4e-06%2C (24.15%25 identity in 211 aa overlap)%3B P25539|RIBD_ECOLI|RIBG|B0414 from Escherichia coli strain K12 (367 aa)%2C FASTA scores: opt: 185%2C E(): 0.00026%2C (26.7%25 identity in 221 aa overlap)%3B etc. But also similar to several hydrolases e.g. Q9X825|SC9B1.05 putative hydrolase from Streptomyces coelicolor (265 aa)%2C FASTA scores: opt: 536%2C E(): 2.9e-26%2C (44.25%25 identity in 235 aa overlap)%3B Q9RKM1|SCD17.10 putative bifunctional enzyme deaminase/reductase from Streptomyces coelicolor (376 aa)%2CFASTA scores: opt: 228%2C E(): 5.6e-07%2C (33.5%25 identity in 188 aa overlap)%3B etc. Equivalent to AAK47060 from Mycobacterium tuberculosis strain CDC1551 (239 aa) but longer 19 aa. Supposed belong to the cytidine and deoxycytidylate deaminases family in the N-terminal section%3B and to the HTP reductase family in the C-terminal section.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ribD;locus_tag=Rv2671;product=Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase);protein_id=CCP45469.1;transl_table=11
AL123456.3	EMBL	gene	2987682	2989268	.	+	.	ID=gene-Rv2672;Name=Rv2672;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2672
AL123456.3	EMBL	CDS	2987682	2989268	.	+	0	ID=cds-CCP45470.1;Parent=gene-Rv2672;Dbxref=EnsemblGenomes-Gn:Rv2672,EnsemblGenomes-Tr:CCP45470,GOA:P71969,InterPro:IPR013595,InterPro:IPR029058,UniProtKB/TrEMBL:P71969,NCBI_GP:CCP45470.1;Name=CCP45470.1;Note=Rv2672%2C (MTCY441.41)%2C len: 528 aa. Possible secreted protease%2C equivalent to O05685|MLC1351.24|ML1339 putative secreted protease from Mycobacterium leprae (525 aa)%2C FASTA scores: opt: 2722%2C E(): 9.4e-140%2C (74.45%25 identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE proteinase from Streptomyces lividans (513 aa)%2C FASTA scores: opt: 429%2C E(): 6.8e-16%2C (26.2%25 identity in 538 aa overlap)%3B Q9FCK9|2SC3B6.03c peptidase from Streptomyces coelicolor (513 aa)%2C FASTA scores: opt: 421%2C E(): 1.8e-15%2C(26.45%25 identity in 541 aa overlap)%3B Q10508|YM23_MYCTU from Mycobacterium tuberculosis (520 aa)%2C FASTA scores: opt: 349%2C E(): 1.4e-11%2C (26.6%25 identity in 523 aa overlap)%3B etc. Equivalent to AAK47061 from Mycobacterium tuberculosis strain CDC1551 (518 aa) but longer 10 aa. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2672;product=Possible secreted protease;protein_id=CCP45470.1;transl_table=11
AL123456.3	EMBL	gene	2989291	2990592	.	+	.	ID=gene-Rv2673;Name=aftC;gbkey=Gene;gene=aftC;gene_biotype=protein_coding;locus_tag=Rv2673
AL123456.3	EMBL	CDS	2989291	2990592	.	+	0	ID=cds-CCP45471.1;Parent=gene-Rv2673;Dbxref=EnsemblGenomes-Gn:Rv2673,EnsemblGenomes-Tr:CCP45471,GOA:P9WMZ7,InterPro:IPR018584,NCBI_GP:CCP45471.1;Name=CCP45471.1;Note=Rv2673%2C (MTCY441.42)%2C len: 433 aa. Possible aftC%2Carabinofuranosyltransferase (See Birch et al.%2C 2008). Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Possible conserved integral membrane protein%2C equivalent to MLC1351.25|ML1338 possible conserved integral membrane protein from Mycobacterium leprae (440 aa)%2C FASTA scores: opt: 2410%2C E(): 5.3e-143%2C (82.05%25 identity in 434 aa overlap)%3B and showing some similarity with Q9CBX0|ML1504 probable conserved membrane protein from Mycobacterium leprae (430 aa)%2C FASTA scores: opt: 159%2C E(): 0.014%2C (24.4%25 identity in 340 aa overlap). Also similar to Q53873|SC6G4.11 putative integral membrane protein from Streptomyces coelicolor (411 aa)%2C FASTA scores: opt: 383%2CE(): 1.4e-16%2C (29.6%25 identity in 422 aa overlap)%3B and with weak similarity with P71061|YVFB hypothetical protein from Bacillus subtilis (396 aa)%2C FASTA scores: opt: 136%2C E(): 0.36%2C (24.35%25 identity in 279 aa overlap)%3B and BAB60134|TVG1014811 hypothetical protein from Thermoplasma volcanium (695 aa)%2C FASTA scores: opt: 133%2C E(): 0.85%2C(26.45%25 identity in 280 aa overlap). Shows also some similarity with O06557|Rv1159|MTCI65.26 hypothetical 47.1 KDA protein from Mycobacterium tuberculosis (431 aa)%2C FASTA scores: opt: 149%2C E(): 0.059%2C (22.45%25 identity in 410 aa overlap)%3B and O53515|Rv2181|MTV021.14 putative membrane protein from Mycobacterium tuberculosis (427 aa)%2C FASTA scores: opt: 129%2C E(): 1%2C (24.8%25 identity in 367 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aftC;locus_tag=Rv2673;product=Possible arabinofuranosyltransferase AftC;protein_id=CCP45471.1;transl_table=11
AL123456.3	EMBL	gene	2990706	2991116	.	+	.	ID=gene-Rv2674;Name=msrB;gbkey=Gene;gene=msrB;gene_biotype=protein_coding;locus_tag=Rv2674
AL123456.3	EMBL	CDS	2990706	2991116	.	+	0	ID=cds-CCP45472.1;Parent=gene-Rv2674;Dbxref=EnsemblGenomes-Gn:Rv2674,EnsemblGenomes-Tr:CCP45472,GOA:I6YA00,InterPro:IPR002579,InterPro:IPR011057,InterPro:IPR028427,UniProtKB/TrEMBL:I6YA00,NCBI_GP:CCP45472.1;Name=CCP45472.1;Note=Rv2674%2C (MTCY441.43)%2C len: 136 aa. Probable msrB%2Cpeptide methionine sulfoxide reductase (See Lee et al.%2C2008)%2C highly similar to various proteins e.g. Q9X828|SC9B1.08 putative oxidoreductase from Streptomyces coelicolor (135 aa)%2C FASTA scores: opt: 653%2C E(): 1.8e-37%2C(71.1%25 identity in 128 aa overlap)%3B O26807|MTH711 transcriptional regulator from Methanothermobacter thermautotrophicus (151 aa)%2C FASTA scores: opt: 533%2C E(): 2.7e-29%2C (58.15%25 identity in 129 aa overlap)%3B Q9C5C8|AT4G21860 hypothetical 22.0 KDA protein from Arabidopsis thaliana (Mouse-ear cress) (202 aa)%2C FASTA scores: opt: 490%2C E(): 2.8e-26%2C (54.05%25 identity in 124 aa overlap)%3B P39903|YEAA_ECOLI|B1778|Z2817|ECS2487 hypothetical protein from Escherichia coli strains K12 and O157:H7 (137 aa)%2C FASTA scores: opt: 426%2C E(): 4.4e-22%2C(46.8%25 identity in 126 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=msrB;locus_tag=Rv2674;product=Probable peptide methionine sulfoxide reductase MsrB (protein-methionine-R-oxide reductase) (peptide met(O) reductase);protein_id=CCP45472.1;transl_table=11
AL123456.3	EMBL	gene	2991184	2991936	.	-	.	ID=gene-Rv2675c;Name=Rv2675c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2675c
AL123456.3	EMBL	CDS	2991184	2991936	.	-	0	ID=cds-CCP45473.1;Parent=gene-Rv2675c;Dbxref=EnsemblGenomes-Gn:Rv2675c,EnsemblGenomes-Tr:CCP45473,GOA:I6Y1G8,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:I6Y1G8,NCBI_GP:CCP45473.1;Name=CCP45473.1;Note=Rv2675c%2C (MTCY441.44c)%2C len: 250 aa. Conserved hypothetical protein. C-terminus highly similar to Q50010|U1764Z from Mycobacterium leprae (69 aa)%2C FASTA scores: opt: 284%2C E(): 4.6e-11%2C (68.25%25 identity in 63 aa overlap). Shows some similarity with Q9P3V6|SPAC1348.04 (alias Q9P3E7|Q9P7U5) hypothetical 16.6 KDA protein from Schizosaccharomyces pombe (Fission yeast) (145 aa)%2C FASTA scores: opt: 203%2C E(): 9.5e-06%2C (33.05%25 identity in 118 aa overlap)%3B Q9ZSZ7|BMCT methyl chloride transferase from Batis maritima (230 aa)%2C FASTA scores: opt: 197%2C E(): 3.3e-05%2C (28.85%25 identity in 156 aa overlap)%3B P72459|STSG methyltransferase from Streptomyces griseus (253 aa)%2C FASTA scores: opt: 194%2C E(): 5.5e-05%2C (24.45%25 identity in 229 aa overlap)%3B etc. Also similar to various proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c hypothetical 22.8 KDA protein (212 aa)%2C FASTA scores: opt: 431%2C E(): 8.3e-20%2C (39.1%25 identity in 197 aa overlap)%3B O06426|Rv0560c|MTCY25D10.39c hypothetical 25.9 KDA protein (241 aa)%2C FASTA scores: opt: 379%2C E(): 1.6e-16%2C (35.95%25 identity in 178 aa overlap)%3B O69667|Rv3699|MTV025.047 putative methyltransferase (233 aa)%2C FASTA scores: opt: 297%2C E(): 2e-11%2C (30.55%25 identity in 193 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2675c;product=Conserved hypothetical protein;protein_id=CCP45473.1;transl_table=11
AL123456.3	EMBL	gene	2991933	2992628	.	-	.	ID=gene-Rv2676c;Name=Rv2676c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2676c
AL123456.3	EMBL	CDS	2991933	2992628	.	-	0	ID=cds-CCP45474.1;Parent=gene-Rv2676c;Dbxref=EnsemblGenomes-Gn:Rv2676c,EnsemblGenomes-Tr:CCP45474,GOA:P9WL45,InterPro:IPR010644,InterPro:IPR011008,NCBI_GP:CCP45474.1;Name=CCP45474.1;Note=Rv2676c%2C (MTCY441.45c)%2C len: 231 aa. Conserved protein%2C equivalent to Q9CCB2|ML1045 (alias Q50009|U1764Y but longer 66 aa) hypothetical protein from Mycobacterium leprae (231 aa)%2C FASTA scores: opt: 1401%2C E(): 8.7e-88%2C(87.45%25 identity in 231 aa overlap). Also highly similar to O69830|SC1B5.02 hypothetical 28.1 KDA protein from Streptomyces coelicolor (243 aa)%2C FASTA scores: opt: 915%2CE(): 7.7e-55%2C (61.25%25 identity in 222 aa overlap)%3B and similar to others e.g. Q9RUB0|DR1481 conserved hypothetical protein from Deinococcus radiodurans (289 aa)%2C FASTA scores: opt: 327%2C E(): 6.1e-15%2C (31.8%25 identity in 176 aa overlap)%3B Q97WP2|SSO2169 hypothetical protein from Sulfolobus solfataricus (223 aa)%2C FASTA scores: opt: 285%2CE(): 3.4e-12%2C (31.3%25 identity in 163 aa overlap)%3B BAB59947|TVG0805714 hypothetical protein from Thermoplasma volcanium (223 aa)%2C FASTA scores: opt: 206%2C E(): 7.7e-07%2C(25.0%25 identity in 176 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2676c;product=Conserved protein;protein_id=CCP45474.1;transl_table=11
AL123456.3	EMBL	gene	2992634	2993992	.	-	.	ID=gene-Rv2677c;Name=hemY;gbkey=Gene;gene=hemY;gene_biotype=protein_coding;locus_tag=Rv2677c
AL123456.3	EMBL	CDS	2992634	2993992	.	-	0	ID=cds-CCP45475.1;Parent=gene-Rv2677c;Dbxref=EnsemblGenomes-Gn:Rv2677c,EnsemblGenomes-Tr:CCP45475,GOA:P9WMP1,InterPro:IPR002937,InterPro:IPR004572,InterPro:IPR027418,NCBI_GP:CCP45475.1;Name=CCP45475.1;Note=Rv2677c%2C (MT2751%2C MTV010.01c)%2C len: 452 aa. Probable hemY%2C protoporphyrinogen oxidase%2C equivalent to Q50008|PPOX_MYCLE|HEMY|ML1044 protoporphyrinogen oxidase from Mycobacterium leprae (451 aa)%2C FASTA scores: opt: 2211%2C E(): 8.8e-118%2C (75.4%25 identity in 455 aa overlap). Also similar to others e.g. Q9RV99|DR1130 from Deinococcus radiodurans (462 aa)%2C FASTA scores: opt: 523%2C E(): 2.7e-22%2C(29.8%25 identity in 453 aa overlap)%3B O32434|PPOX_PROFR|HEMY from Propionibacterium freudenreichii shermanii (527 aa)%2CFASTA scores: opt: 344%2C E(): 4e-12%2C (32.1%25 identity in 495 aa overlap)%3B P32397|PPOX_BACSU|HEMY|HEMG from Bacillus subtilis (470 aa)%2C FASTA scores: opt: 305%2C E(): 5.9e-10%2C(26.8%25 identity in 463 aa overlap)%3B etc. Belongs to the protoporphyrinogen oxidase family. Cofactor: contains one FAD per homodimer.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemY;locus_tag=Rv2677c;product=Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO);protein_id=CCP45475.1;transl_table=11
AL123456.3	EMBL	gene	2993989	2995062	.	-	.	ID=gene-Rv2678c;Name=hemE;gbkey=Gene;gene=hemE;gene_biotype=protein_coding;locus_tag=Rv2678c
AL123456.3	EMBL	CDS	2993989	2995062	.	-	0	ID=cds-CCP45476.1;Parent=gene-Rv2678c;Dbxref=EnsemblGenomes-Gn:Rv2678c,EnsemblGenomes-Tr:CCP45476,GOA:P9WFE1,InterPro:IPR000257,InterPro:IPR006361,NCBI_GP:CCP45476.1;Name=CCP45476.1;Note=Rv2678c%2C (MTV010.02c)%2C len: 357 aa. Probable hemE%2Curoporphyrinogen decarboxylase%2C equivalent to P46809|DCUP_MYCLE|heme|ML1043 uroporphyrinogen decarboxylase from Mycobacterium leprae (357 aa)%2C FASTA scores: opt: 2017%2C E(): 8.2e-111%2C (83.75%25 identity in 357 aa overlap). Also highly similar to many e.g. O69861|DCUP_STRCO|heme|SC1C3.19 from Streptomyces coelicolor (355 aa)%2C FASTA scores: opt: 1165%2C E(): 5.6e-61%2C(58.15%25 identity in 349 aa overlap)%3B P32395|DCUP_BACSU|heme from Bacillus subtilis (353 aa)%2C FASTA scores: opt: 859%2CE(): 4.5e-43%2C (44.1%25 identity in 356 aa overlap)%3B Q9RV96|DCUP_DEIRA|heme|DR1133 from Deinococcus radiodurans (344 aa)%2C FASTA scores: opt: 850%2C E(): 1.5e-42%2C (43.0%25 identity in 349 aa overlap)%3B etc. Equivalent to AAK47067 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but shorter 15 aa. Contains PS00907 Uroporphyrinogen decarboxylase signature 2. Belongs to the uroporphyrinogen decarboxylase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hemE;inference=protein motif:PROSITE:PS00907;locus_tag=Rv2678c;product=Probable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD);protein_id=CCP45476.1;transl_table=11
AL123456.3	EMBL	gene	2995115	2995945	.	+	.	ID=gene-Rv2679;Name=echA15;gbkey=Gene;gene=echA15;gene_biotype=protein_coding;locus_tag=Rv2679
AL123456.3	EMBL	CDS	2995115	2995945	.	+	0	ID=cds-CCP45477.1;Parent=gene-Rv2679;Dbxref=EnsemblGenomes-Gn:Rv2679,EnsemblGenomes-Tr:CCP45477,GOA:I6YA03,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,UniProtKB/TrEMBL:I6YA03,NCBI_GP:CCP45477.1;Name=CCP45477.1;Note=Rv2679%2C (MTV010.03)%2C len: 276 aa. Probable echA15%2Cenoyl-CoA hydratase%2C similar to P53526|ECHC_MYCLE|ECHA12|ML1241|MLCB1610.01|B1170_C2_224 probable enoyl-CoA hydratase from Mycobacterium leprae (294 aa)%2C FASTA scores: opt: 368%2C E(): 2.5e-16%2C (32.15%25 identity in 277 aa overlap). Also highly similar to Q9RXX1|DR0184 from Deinococcus radiodurans (273 aa)%2C FASTA scores: opt: 993%2C E(): 2.2e-56%2C (58.15%25 identity in 263 aa overlap)%3B and similar to many e.g. Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa)%2C FASTA scores: opt: 396%2C E(): 3.8e-18%2C (34.9%25 identity in 258 aa overlap)%3B O29299|AF0963|FAD-3 from Archaeoglobus fulgidus (259 aa)%2C FASTA scores: opt: 363%2CE(): 4.7e-16%2C (30.4%25 identity in 250 aa overlap)%3B P77467|PAAG_ECOLI|B1394 from Escherichia coli strain W (262 aa)%2C FASTA scores: opt: 357%2C E(): 1.1e-15%2C (31.75%25 identity in 252 aa overlap)%3B etc. Also similar to O53163|ECHC_MYCTU|ECHA12|FADB2|Rv1472|MT1518|MTV007.19 enoyl-CoA hydratase from Mycobacterium tuberculosis (285 aa)%2C FASTA scores: opt: 355%2C E(): 1.6e-15%2C (31.3%25 identity in 265 aa overlap)%3B and O06542|ECHA10|Rv1142c|MTCI65.09c|Z95584 enoyl-CoA hydratase from Mycobacterium tuberculosis (268 aa). Contains PS00166 Enoyl-CoA hydratase/isomerase signature. Belongs to the enoyl-CoA hydratase/isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA15;inference=protein motif:PROSITE:PS00166;locus_tag=Rv2679;product=Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP45477.1;transl_table=11
AL123456.3	EMBL	repeat_region	2996003	2996053	.	+	.	ID=id-AL123456.3:2996003..2996053;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	2996054	2996104	.	+	.	ID=id-AL123456.3:2996054..2996104;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	2996105	2996737	.	+	.	ID=gene-Rv2680;Name=Rv2680;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2680
AL123456.3	EMBL	CDS	2996105	2996737	.	+	0	ID=cds-CCP45478.1;Parent=gene-Rv2680;Dbxref=EnsemblGenomes-Gn:Rv2680,EnsemblGenomes-Tr:CCP45478,InterPro:IPR021555,UniProtKB/TrEMBL:O86317,NCBI_GP:CCP45478.1;Name=CCP45478.1;Note=Rv2680%2C (MTV010.04)%2C len: 210 aa. Conserved protein%2Cequivalent to Q50005|ML1041|U1764V hypothetical protein from Mycobacterium leprae (196 aa)%2C FASTA scores: opt: 1136%2C E(): 9.7e-66%2C (83.95%25 identity in 193 aa overlap). Also similar to O69860|SC1C3.18c hypothetical 24.7 KDA protein from Streptomyces coelicolor (238 aa)%2C FASTA scores: opt: 516%2C E(): 5.7e-26%2C (45.5%25 identity in 189 aa overlap)%3B and similar in part to Q9I6V4|PA0178 probable two-component sensor from Pseudomonas aeruginosa (639 aa)%2CFASTA scores: opt: 120%2C E(): 3.1%2C (33.05%25 identity in 115 aa overlap)%3B and a few other proteins. Equivalent to AAK47069 from Mycobacterium tuberculosis strain CDC1551 (178 aa) but longer 32 aa%3B and N-terminus highly similar to N-terminus of AAK48352|MT3984 hypothetical 4.2 KDA protein from Mycobacterium tuberculosis strain CDC1551 (38 aa)%2CFASTA scores: opt: 102%2C E(): 3.6%2C (62.05%25 identity in 29 aa overlap). Nucleotide position 2996194 in the genome sequence has been corrected%2C T:A resulting in V30V.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2680;product=Conserved protein;protein_id=CCP45478.1;transl_table=11
AL123456.3	EMBL	repeat_region	2996105	2996155	.	+	.	ID=id-Rv2680;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region;locus_tag=Rv2680
AL123456.3	EMBL	gene	2996739	2998055	.	+	.	ID=gene-Rv2681;Name=Rv2681;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2681
AL123456.3	EMBL	CDS	2996739	2998055	.	+	0	ID=cds-CCP45479.1;Parent=gene-Rv2681;Dbxref=EnsemblGenomes-Gn:Rv2681,EnsemblGenomes-Tr:CCP45479,GOA:I6XF17,InterPro:IPR002121,InterPro:IPR002562,InterPro:IPR010997,InterPro:IPR012337,UniProtKB/TrEMBL:I6XF17,NCBI_GP:CCP45479.1;Name=CCP45479.1;Note=Rv2681%2C (MTCY05A6.02)%2C len: 438 aa. Conserved hypothetical ala-rich protein%2C equivalent to Q50004|ML1040|U1764U hypothetical protein from Mycobacterium leprae (429 aa)%2C FASTA scores: opt: 2146%2CE(): 1.1e-119%2C (77.4%25 identity in 416 aa overlap). Also highly similar to O69858|SC1C3.16c hypothetical 42.5 KDA protein from Streptomyces coelicolor (394 aa)%2C FASTA scores: opt: 1336%2C E(): 9e-72%2C (51.6%25 identity in 405 aa overlap)%3B and with some similarity to ribonucleases D e.g. Q983F2|MLL8354 from Rhizobium loti (Mesorhizobium loti) (383 aa)%2C FASTA scores: opt: 379%2C E(): 3.9e-15%2C (31.6%25 identity in 323 aa overlap)%3B Q9A7L8|CC1704 from Caulobacter crescentus (389 aa)%2C FASTA scores: opt: 370%2C E(): 1.3e-14%2C(31.45%25 identity in 318 aa overlap)%3B CAC45770 from Rhizobium meliloti (Sinorhizobium meliloti) (383 aa)%2C FASTA scores: opt: 331%2C E(): 2.7e-12%2C (27.75%25 identity in 357 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2681;product=Conserved hypothetical alanine rich protein;protein_id=CCP45479.1;transl_table=11
AL123456.3	EMBL	gene	2998052	2999968	.	-	.	ID=gene-Rv2682c;Name=dxs1;gbkey=Gene;gene=dxs1;gene_biotype=protein_coding;gene_synonym=dxs;locus_tag=Rv2682c
AL123456.3	EMBL	CDS	2998052	2999968	.	-	0	ID=cds-CCP45480.1;Parent=gene-Rv2682c;Dbxref=EnsemblGenomes-Gn:Rv2682c,EnsemblGenomes-Tr:CCP45480,GOA:P9WNS3,InterPro:IPR005474,InterPro:IPR005475,InterPro:IPR005476,InterPro:IPR005477,InterPro:IPR009014,InterPro:IPR020826,InterPro:IPR029061,NCBI_GP:CCP45480.1;Name=CCP45480.1;Note=Rv2682c%2C (MTCY05A6.03c)%2C len: 638 aa. Probable dxs1%2C1-deoxy-D-xylulose 5-phosphate synthase%2C equivalent to Q50000|DXS_MYCLE|TKTB|ML1038 1-deoxy-D-xylulose 5-phosphate synthase from Mycobacterium leprae (643 aa)%2C FASTA scores: opt: 3635%2C E(): 5.6e-209%2C (86.4%25 identity in 632 aa overlap). Also highly similar to other Q9X7W3|DXS_STRCO|DXS|SC6A5.17 from Streptomyces coelicolor (656 aa)%2C FASTA scores: opt: 2501%2C E(): 2e-141%2C (61.3%25 identity in 623 aa overlap)%3B Q9K971|DXS_BACHD|DXS|BH2779 from Bacillus halodurans (629 aa)%2C FASTA scores: opt: 1612%2CE(): 1.8e-88%2C (41.35%25 identity in 619 aa overlap)%3B P77488|DXS_ECOLI|DXS|B0420 from Escherichia coli strain K12 (619 aa)%2C FASTA scores: opt: 1511%2C E(): 1.8e-82%2C (39.5%25 identity in 625 aa overlap)%3B etc. Also similar to O50408|Rv3379c|MTV004.37c from Mycobacterium tuberculosis (536 aa). Belongs to the transketolase family. DXS subfamily. Cofactor: thiamine pyrophosphate. Note that previously known as dxs.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dxs1;locus_tag=Rv2682c;product=Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS);protein_id=CCP45480.1;transl_table=11
AL123456.3	EMBL	gene	3000112	3000609	.	+	.	ID=gene-Rv2683;Name=Rv2683;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2683
AL123456.3	EMBL	CDS	3000112	3000609	.	+	0	ID=cds-CCP45481.1;Parent=gene-Rv2683;Dbxref=EnsemblGenomes-Gn:Rv2683,EnsemblGenomes-Tr:CCP45481,GOA:I6X540,InterPro:IPR000644,InterPro:IPR013785,UniProtKB/TrEMBL:I6X540,NCBI_GP:CCP45481.1;Name=CCP45481.1;Note=Rv2683%2C (MTCY05A6.04)%2C len: 165 aa. Conserved protein%2C equivalent%2C but shorter 19 aa%2C to Q49999|ML1037|U1764Q hypothetical protein from Mycobacterium leprae (184 aa)%2C FASTA scores: opt: 750%2C E(): 1.2e-41%2C (73.8%25 identity in 164 aa overlap). Shows some similarity with other hypothetical proteins e.g. Q988S9|MLL6611 from Rhizobium loti (Mesorhizobium loti) (232 aa)%2C FASTA scores: opt: 128%2C E(): 0.25%2C (25.5%25 identity in 149 aa overlap)%3B Q9YFL5|APE0233 from Aeropyrum pernix (340 aa)%2C FASTA scores: opt: 123%2C E(): 0.73%2C (29.1%25 identity in 141 aa overlap)%3B BAB60477|TVG1377730 from Thermoplasma volcanium (174 aa)%2C FASTA scores: opt: 118%2CE(): 0.86%2C (28.8%25 identity in 59 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2683;product=Conserved protein;protein_id=CCP45481.1;transl_table=11
AL123456.3	EMBL	gene	3000614	3001903	.	+	.	ID=gene-Rv2684;Name=arsA;gbkey=Gene;gene=arsA;gene_biotype=protein_coding;locus_tag=Rv2684
AL123456.3	EMBL	CDS	3000614	3001903	.	+	0	ID=cds-CCP45482.1;Parent=gene-Rv2684;Dbxref=EnsemblGenomes-Gn:Rv2684,EnsemblGenomes-Tr:CCP45482,GOA:P9WPD9,InterPro:IPR000802,InterPro:IPR004680,NCBI_GP:CCP45482.1;Name=CCP45482.1;Note=Rv2684%2C (MTCY05A6.05)%2C len: 429 aa. Probable arsA%2Carsenic-transport integral membrane protein%2C equivalent to P46838|AG45_MYCLE|ML1036 46 KDA probable integral membrane protein (antigen 45%2C a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa)%2C FASTA scores: opt: 2067%2C E(): 9.9e-118%2C (74.05%25 identity in 428 aa overlap)%3B and upstream orf O07187|YQ85_MYCTU|ARSB|Rv2685|MT2759|MTCY05A6.06 probable integral membrane 45.2 KDA protein ARSB from Mycobacterium tuberculosis (428 aa)%2C FASTA scores: opt: 2148%2C E(): 1.3e-122%2C (76.58%25 identity in 427 aa overlap). Also highly similar to other proteins e.g. Q9UY19|PAB1107 transport protein from Pyrococcus abyssi (425 aa)%2C FASTA scores: opt: 1109%2C E(): 8.3e-60%2C (41.45%25 identity in 427 aa overlap)%3B O59575|PH1912 hypothetical 46.0 KDA protein from Pyrococcus horikoshii (424 aa)%2C FASTA scores: opt: 1101%2C E(): 2.5e-59%2C(41.95%25 identity in 429 aa overlap)%3B Q9KDI2|BH1231 hypothetical 46.0 KDA protein from Bacillus halodurans (428 aa)%2C FASTA scores: opt: 1018%2C E(): 2.7e-54%2C (38.9%25 identity in 427 aa overlap)%3B etc. Belongs to the NADC/P/PHO87 family of transporters%2C P subfamily (ARS family).;gbkey=CDS;gene=arsA;locus_tag=Rv2684;product=Probable arsenic-transport integral membrane protein ArsA;protein_id=CCP45482.1;transl_table=11
AL123456.3	EMBL	gene	3001983	3003269	.	+	.	ID=gene-Rv2685;Name=arsB1;gbkey=Gene;gene=arsB1;gene_biotype=protein_coding;gene_synonym=arsB;locus_tag=Rv2685
AL123456.3	EMBL	CDS	3001983	3003269	.	+	0	ID=cds-CCP45483.1;Parent=gene-Rv2685;Dbxref=EnsemblGenomes-Gn:Rv2685,EnsemblGenomes-Tr:CCP45483,GOA:P9WPD7,InterPro:IPR000802,InterPro:IPR004680,NCBI_GP:CCP45483.1;Name=CCP45483.1;Note=Rv2685%2C (MTCY05A6.06)%2C len: 428 aa. Probable arsB1%2Carsenic-transport integral membrane protein%2C equivalent to P46838|AG45_MYCLE|ML1036 46 KDA probable integral membrane protein (antigen 45%2C a transmembrane protein related to arsenical pumps) from Mycobacterium leprae (429 aa)%2C FASTA scores: opt: 2048%2C E(): 7.3e-120%2C (74.25%25 identity in 427 aa overlap)%3B and downstream ORF O07186|YQ84_MYCTU|ARSA|Rv2684|MT2758|MTCY05A6.05 probable integral membrane protein ARSA from Mycobacterium tuberculosis (429 aa)%2C FASTA scores: opt: 2154%2C E(): 1.9e-126%2C (76.8%25 identity in 427 aa overlap). Also highly similar to other proteins e.g. O59575|PH1912 hypothetical 46.0 KDA protein from Pyrococcus horikoshii (424 aa)%2C FASTA scores: opt: 1075%2C E(): 1.9e-59%2C (43.55%25 identity in 427 aa overlap)%3B Q9UY19|PAB1107 transport protein from Pyrococcus abyssi (425 aa)%2C FASTA scores: opt: 1062%2C E(): 1.3e-58%2C(41.8%25 identity in 428 aa overlap)%3B Q9KDI2|BH1231 hypothetical 46.0 KDA protein from Bacillus halodurans (428 aa)%2C FASTA scores: opt: 993%2C E(): 2.4e-54%2C (39.55%25 identity in 430 aa overlap)%3B etc. Belongs to the NADC/P/PHO87 family of transporters%2C P subfamily. Note that previously known as arsB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=arsB1;locus_tag=Rv2685;product=Probable arsenic-transport integral membrane protein ArsB1;protein_id=CCP45483.1;transl_table=11
AL123456.3	EMBL	gene	3003280	3004038	.	-	.	ID=gene-Rv2686c;Name=Rv2686c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2686c
AL123456.3	EMBL	CDS	3003280	3004038	.	-	0	ID=cds-CCP45484.1;Parent=gene-Rv2686c;Dbxref=EnsemblGenomes-Gn:Rv2686c,EnsemblGenomes-Tr:CCP45484,GOA:P9WJB3,NCBI_GP:CCP45484.1;Name=CCP45484.1;Note=Rv2686c%2C (MTCY05A6.07c)%2C len: 252 aa. Antibiotic-transport integral membrane leu-%2C ala-%2C val-rich protein ABC transporter (see citation below). The region from aa ~~115 to 160 is highly similar to N-terminus of Q49998|U1764P hypothetical protein from Mycobacterium leprae (53 aa)%2C FASTA scores: opt: 151%2C E(): 0.011%2C (58.15%25 identity in 43 aa overlap). Shows some similarity with membrane proteins e.g. AAK75541|SP1447 membrane protein from Streptococcus pneumoniae (298 aa)%2C FASTA scores: opt: 139%2C E(): 0.21%2C (29.65%25 identity in 135 aa overlap)%3B Q9K4C9|2SC6G5.26c putative ABC transporter integral membrane subunit from Streptomyces coelicolor (249 aa)%2CFASTA scores: opt: 138%2C E(): 0.21%2C (26.9%25 identity in 253 aa overlap)%3B Q53627|MTRB membrane protein involved in mithramycin resistance from Streptomyces argillaceus (233 aa)%2C FASTA scores: opt: 136%2C E(): 0.27%2C (26.7%25 identity in 191 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2686c;product=Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter;protein_id=CCP45484.1;transl_table=11
AL123456.3	EMBL	gene	3004035	3004748	.	-	.	ID=gene-Rv2687c;Name=Rv2687c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2687c
AL123456.3	EMBL	CDS	3004035	3004748	.	-	0	ID=cds-CCP45485.1;Parent=gene-Rv2687c;Dbxref=EnsemblGenomes-Gn:Rv2687c,EnsemblGenomes-Tr:CCP45485,GOA:P9WJB1,InterPro:IPR013525,NCBI_GP:CCP45485.1;Name=CCP45485.1;Note=Rv2687c%2C (MTCY05A6.08c)%2C len: 237 aa. Antibiotic-transport integral membrane leu-%2C val-rich protein ABC transporter (see citation below)%2C showing some similarity with two other hypothetical proteins%2CBAB59668|TVG0517148 from Thermoplasma volcanium (241 aa)%2CFASTA scores: opt: 136%2C E(): 0.32%2C (23.1%25 identity in 208 aa overlap)%3B and Q97U55|SSO3168 from Sulfolobus solfataricus (249 aa)%2C FASTA scores: opt: 136%2C E(): 0.33%2C(25.15%25 identity in 195 aa overlap). Has some hydrophobic stretches and contains bacterial regulatory proteins%2C araC family signature (PS00041).;gbkey=CDS;inference=protein motif:PROSITE:PS00041;locus_tag=Rv2687c;product=Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter;protein_id=CCP45485.1;transl_table=11
AL123456.3	EMBL	gene	3004745	3005650	.	-	.	ID=gene-Rv2688c;Name=Rv2688c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2688c
AL123456.3	EMBL	CDS	3004745	3005650	.	-	0	ID=cds-CCP45486.1;Parent=gene-Rv2688c;Dbxref=EnsemblGenomes-Gn:Rv2688c,EnsemblGenomes-Tr:CCP45486,GOA:P9WQL7,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR027417,NCBI_GP:CCP45486.1;Name=CCP45486.1;Note=Rv2688c%2C (MTCY05A6.09c)%2C len: 301 aa. Antibiotic-transport ATP-binding protein ABC transporter (see citation below)%2C highly similar to AAK47077|MT2762 ABC transporter ATP-binding protein from Mycobacterium tuberculosis strain CDC1551 (317 aa)%2C FASTA scores: opt: 1714%2C E(): 5.1e-93%2C (95.6%25 identity in 274 aa overlap). Also highly similar to other ATP-binding proteins ABC transporter e.g. Q9K639|BH3893 from Bacillus halodurans (282 aa)%2C FASTA scores: opt: 644%2C E(): 1.4e-30%2C (38.%25 identity in 285 aa overlap)%3B O58550|PH0820 from Pyrococcus horikoshii (312 aa)%2C FASTA scores: opt: 574%2C E(): 1.8e-26%2C(39.1%25 identity in 307 aa overlap)%3B Q9WYM0|TM0389 from Thermotoga maritima (301 aa)%2C FASTA scores: opt: 536%2C E(): 2.9e-24%2C (36.1%25 identity in 291 aa overlap)%3B etc. Has ATP/GTP-binding site motif A (P-loop) at N-terminus (PS00017). Belongs to the ATP-binding transport protein family (ABC transporters).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2688c;product=Antibiotic-transport ATP-binding protein ABC transporter;protein_id=CCP45486.1;transl_table=11
AL123456.3	EMBL	gene	3005845	3007062	.	-	.	ID=gene-Rv2689c;Name=Rv2689c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2689c
AL123456.3	EMBL	CDS	3005845	3007062	.	-	0	ID=cds-CCP45487.1;Parent=gene-Rv2689c;Dbxref=EnsemblGenomes-Gn:Rv2689c,EnsemblGenomes-Tr:CCP45487,GOA:O07191,InterPro:IPR002792,InterPro:IPR010280,InterPro:IPR012340,InterPro:IPR029063,UniProtKB/TrEMBL:O07191,NCBI_GP:CCP45487.1;Name=CCP45487.1;Note=Rv2689c%2C (MTCY05A6.10c)%2C len: 405 aa (other less probable starts possible). Conserved ala-%2C val-%2C gly-rich protein%2C similar to O54099|SC10A5.06 hypothetical 49.5 KDA protein from Streptomyces coelicolor (458 aa)%2C FASTA scores: opt: 455%2C E(): 2.7e-20%2C (38.35%25 identity in 417 aa overlap)%3B and shows weak similarity in part with several methyltransferases e.g. Q9X0H9|TM1094 putative RNA methyltransferase from Thermotoga maritima (439 aa)%2C FASTA scores: opt: 306%2C E(): 3e-11%2C (25.9%25 identity in 436 aa overlap)%3B AK79403|CAC1435 S-adenosylmethionine-dependent methyltransferases from Clostridium acetobutylicum (456 aa)%2C FASTA scores: opt: 294%2C E(): 1.6e-10%2C (23.4%25 identity in 449 aa overlap)%3B Q9A8M7|CC1326 RNA methyltransferase from Caulobacter crescentus (415 aa)%2C FASTA scores: opt: 247%2C E(): 1.1e-07%2C (28.4%25 identity in 433 aa overlap)%3B etc. Equivalent to AAK47078 from Mycobacterium tuberculosis strain CDC1551 (434 aa) but shorter 29 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2689c;product=Conserved alanine and valine and glycine rich protein;protein_id=CCP45487.1;transl_table=11
AL123456.3	EMBL	repeat_region	3007063	3007115	.	-	.	ID=id-AL123456.3:3007063..3007115;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3007116	3007168	.	-	.	ID=id-AL123456.3:3007116..3007168;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3007169	3007221	.	-	.	ID=id-AL123456.3:3007169..3007221;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	3007236	3009209	.	-	.	ID=gene-Rv2690c;Name=Rv2690c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2690c
AL123456.3	EMBL	CDS	3007236	3009209	.	-	0	ID=cds-CCP45488.1;Parent=gene-Rv2690c;Dbxref=EnsemblGenomes-Gn:Rv2690c,EnsemblGenomes-Tr:CCP45488,GOA:I6Y1H7,InterPro:IPR002293,UniProtKB/TrEMBL:I6Y1H7,NCBI_GP:CCP45488.1;Name=CCP45488.1;Note=Rv2690c%2C (MTCY05A6.11c)%2C len: 657 aa. Probable conserved integral membrane ala-%2C val-%2C leu-rich protein%2Chighly similar to others e.g. O54098|SC10A5.05 putative membrane protein from Streptomyces coelicolor (691 aa)%2CFASTA scores: opt: 2007%2C E(): 1.6e-116%2C (62.35%25 identity in 669 aa overlap)%3B O69917|SC3C8.04c putative integral membrane protein from Streptomyces coelicolor (644 aa)%2CFASTA scores: opt: 923%2C E(): 1.7e-49%2C (35.3%25 identity in 669 aa overlap)%3B AAK78253|CAC0272 amino acid transporter from Clostridium acetobutylicum (620 aa)%2C FASTA scores: opt: 674%2C E(): 4.1e-34%2C (36.55%25 identity in 640 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2690c;product=Probable conserved integral membrane alanine and valine and leucine rich protein;protein_id=CCP45488.1;transl_table=11
AL123456.3	EMBL	gene	3009344	3010027	.	+	.	ID=gene-Rv2691;Name=ceoB;gbkey=Gene;gene=ceoB;gene_biotype=protein_coding;gene_synonym=trkA;locus_tag=Rv2691
AL123456.3	EMBL	CDS	3009344	3010027	.	+	0	ID=cds-CCP45489.1;Parent=gene-Rv2691;Dbxref=EnsemblGenomes-Gn:Rv2691,EnsemblGenomes-Tr:CCP45489,GOA:I6XF25,InterPro:IPR003148,InterPro:IPR006036,InterPro:IPR006037,InterPro:IPR016040,UniProtKB/TrEMBL:I6XF25,NCBI_GP:CCP45489.1;Name=CCP45489.1;Note=Rv2691%2C (MTCY05A6.12)%2C len: 227 aa. CeoB (alternate gene name: trkA)%2C TRK system potassium uptake protein (see citation below)%2C highly similar to others e.g. Q53949|TRKA_STRCO|SC2E9.17c from Streptomyces coelicolor (223 aa)%2C FASTA scores: opt: 781%2C E(): 5.8e-42%2C (53.2%25 identity in 220 aa overlap)%3B O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa)%2C FASTA scores: opt: 287%2C E(): 5.3e-11%2C (27.0%25 identity in 211 aa overlap)%3B O54141|SC2E9.16c from Streptomyces coelicolor (226 aa)%2C FASTA scores: opt: 269%2C E(): 7.3e-10%2C (29.9%25 identity in 214 aa overlap)%3B etc. Also similar to upstream orf O07194|CEOC|TRKA_MYCTU|TRKA|TRKB|Rv2692|MT2766|MTCY05A6.13 TRK system potassium uptake protein from Mycobacterium tuberculosis (220 aa)%2C FASTA scores: opt: 259%2C E(): 3e-09%2C(26.55%25 identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). Belongs to the TrkA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ceoB;locus_tag=Rv2691;product=TRK system potassium uptake protein CeoB;protein_id=CCP45489.1;transl_table=11
AL123456.3	EMBL	gene	3010024	3010686	.	+	.	ID=gene-Rv2692;Name=ceoC;gbkey=Gene;gene=ceoC;gene_biotype=protein_coding;gene_synonym=trkA,trkB;locus_tag=Rv2692
AL123456.3	EMBL	CDS	3010024	3010686	.	+	0	ID=cds-CCP45490.1;Parent=gene-Rv2692;Dbxref=EnsemblGenomes-Gn:Rv2692,EnsemblGenomes-Tr:CCP45490,GOA:P9WFZ3,InterPro:IPR003148,InterPro:IPR006036,InterPro:IPR006037,InterPro:IPR016040,NCBI_GP:CCP45490.1;Name=CCP45490.1;Note=Rv2692%2C (MTCY05A6.13)%2C len: 220 aa. CeoC (alternate gene names: trkA and trkB)%2C TRK system potassium uptake protein (see citation below)%2C highly similar to others e.g. O54141|SC2E9.16c from Streptomyces coelicolor (226 aa)%2CFASTA scores: opt: 870%2C E(): 9.4e-48%2C (58.8%25 identity in 216 aa overlap)%3B Q58505|TRKA_METJA|MJ1105 from Methanococcus jannaschii (218 aa)%2C FASTA scores: opt: 361%2CE(): 9.7e-16%2C (29.8%25 identity in 218 aa overlap)%3B O27333|TRKA_METTH|MTH1265 from Methanobacterium thermoautotrophicum (216 aa)%2C FASTA scores: opt: 326%2C E(): 1.5e-13%2C (30.1%25 identity in 216 aa overlap)%3B etc. Also similar to downstream orf O07193|CEOB|TRKA|Rv2691|MTCY05A6.12 TRK system potassium uptake protein from Mycobacterium tuberculosis (227 aa)%2CFASTA scores: opt: 259%2C E(): 2.6e-09%2C (26.55%25 identity in 226 aa overlap). Contains a motif common to NAD+ binding pockets (see citation below). Belongs to the TrkA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ceoC;locus_tag=Rv2692;product=TRK system potassium uptake protein CeoC;protein_id=CCP45490.1;transl_table=11
AL123456.3	EMBL	gene	3010697	3011368	.	-	.	ID=gene-Rv2693c;Name=Rv2693c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2693c
AL123456.3	EMBL	CDS	3010697	3011368	.	-	0	ID=cds-CCP45491.1;Parent=gene-Rv2693c;Dbxref=EnsemblGenomes-Gn:Rv2693c,EnsemblGenomes-Tr:CCP45491,InterPro:IPR016566,UniProtKB/TrEMBL:I6X548,NCBI_GP:CCP45491.1;Name=CCP45491.1;Note=Rv2693c%2C (MTCY05A6.14c)%2C len: 223 aa. Probable conserved integral membrane ala-%2C leu-rich protein%2C showing some similarity to O54140|SC2E9.15 hypothetical 29.6 KDA protein from Streptomyces coelicolor (272 aa)%2C FASTA scores: opt: 212%2C E(): 4.3e-06%2C (23.5%25 identity in 247 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2693c;product=Probable conserved integral membrane alanine and leucine rich protein;protein_id=CCP45491.1;transl_table=11
AL123456.3	EMBL	gene	3011399	3011767	.	-	.	ID=gene-Rv2694c;Name=Rv2694c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2694c
AL123456.3	EMBL	CDS	3011399	3011767	.	-	0	ID=cds-CCP45492.1;Parent=gene-Rv2694c;Dbxref=EnsemblGenomes-Gn:Rv2694c,EnsemblGenomes-Tr:CCP45492,InterPro:IPR012340,InterPro:IPR016499,UniProtKB/TrEMBL:O07196,NCBI_GP:CCP45492.1;Name=CCP45492.1;Note=Rv2694c%2C (MTCY05A6.15c)%2C len: 122 aa. Conserved protein%2C highly similar in part to SC2E9.14 hypothetical 16.9 KDA protein from Streptomyces coelicolor (154 aa)%2CFASTA scores: opt: 299%2C E(): 1.9e-13%2C (41.05%25 identity in 117 aa overlap. Equivalent to AAK47083 from Mycobacterium tuberculosis strain CDC1551 (157 aa) but shorter 35 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2694c;product=Conserved protein;protein_id=CCP45492.1;transl_table=11
AL123456.3	EMBL	gene	3011916	3012623	.	+	.	ID=gene-Rv2695;Name=Rv2695;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2695
AL123456.3	EMBL	CDS	3011916	3012623	.	+	0	ID=cds-CCP45493.1;Parent=gene-Rv2695;Dbxref=EnsemblGenomes-Gn:Rv2695,EnsemblGenomes-Tr:CCP45493,InterPro:IPR029058,UniProtKB/TrEMBL:I6Y1I1,NCBI_GP:CCP45493.1;Name=CCP45493.1;Note=Rv2695%2C (MTCY05A6.16)%2C len: 235 aa. Conserved hypothetical ala-rich protein%2C equivalent to Q49994|ML1030|U1764L hypothetical protein from Mycobacterium leprae (232 aa)%2C FASTA scores: opt: 1166%2CE(): 6.3e-63%2C (76.95%25 identity in 230 aa overlap). Also shows some similarity with other hypothetical proteins e.g. Q986S2|MLR7232 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (277 aa)%2C FASTA scores: opt: 150%2C E(): 0.059%2C (33.55%25 identity in 173 aa overlap)%3B CAC47772|SMC03810 hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (269 aa)%2C FASTA scores: opt: 143%2C E(): 0.15%2C (28.05%25 identity in 228 aa overlap)%3B Q9A5N6|CC2411 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase from Caulobacter crescentus (393 aa)%2C FASTA scores: opt: 138%2CE(): 0.41%2C (26.45%25 identity in 238 aa overlap)%3B etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Nucleotide position 3012293 in the genome sequence has been corrected%2C A:G resulting in T126T.;gbkey=CDS;inference=protein motif:PROSITE:PS00343;locus_tag=Rv2695;product=Conserved hypothetical alanine rich protein;protein_id=CCP45493.1;transl_table=11
AL123456.3	EMBL	gene	3012829	3013608	.	-	.	ID=gene-Rv2696c;Name=Rv2696c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2696c
AL123456.3	EMBL	CDS	3012829	3013608	.	-	0	ID=cds-CCP45494.1;Parent=gene-Rv2696c;Dbxref=EnsemblGenomes-Gn:Rv2696c,EnsemblGenomes-Tr:CCP45494,InterPro:IPR022183,UniProtKB/TrEMBL:I6XF31,NCBI_GP:CCP45494.1;Name=CCP45494.1;Note=Rv2696c%2C (MTCY05A6.17c)%2C len: 259 aa. Conserved ala-%2C gly-%2C val-rich protein%2C equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K hypothetical protein from Mycobacterium leprae (273 aa)%2C FASTA scores: opt: 1174%2CE(): 2.1e-63%2C (70.6%25 identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa)%2C FASTA scores: opt: 213%2C E(): 9.8e-06%2C (28.25%25 identity in 255 aa overlap)%3B and showing weak similarity with other proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2696c;product=Conserved alanine and glycine and valine rich protein;protein_id=CCP45494.1;transl_table=11
AL123456.3	EMBL	repeat_region	3013612	3013687	.	-	.	ID=id-AL123456.3:3013612..3013687;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass I;gbkey=repeat_region
AL123456.3	EMBL	gene	3013683	3014147	.	-	.	ID=gene-Rv2697c;Name=dut;gbkey=Gene;gene=dut;gene_biotype=protein_coding;locus_tag=Rv2697c
AL123456.3	EMBL	CDS	3013683	3014147	.	-	0	ID=cds-CCP45495.1;Parent=gene-Rv2697c;Dbxref=EnsemblGenomes-Gn:Rv2697c,EnsemblGenomes-Tr:CCP45495,GOA:P9WNS5,InterPro:IPR008180,InterPro:IPR008181,InterPro:IPR029054,PDB:1MQ7,PDB:1SIX,PDB:1SJN,PDB:1SLH,PDB:1SM8,PDB:1SMC,PDB:1SNF,PDB:2PY4,PDB:3H6D,PDB:3HZA,PDB:3I93,PDB:3LOJ,PDB:4GCY,NCBI_GP:CCP45495.1;Name=CCP45495.1;Note=Rv2697c%2C (MT2771%2C MTCY05A6.18c)%2C len: 154 aa. Probable dut%2C deoxyuridine 5'-triphosphate nucleotidohydrolase (see citation below)%2C equivalent to Q49992|DUT_MYCLE|ML1028 deoxyuridine 5'-triphosphate nucleotidohydrolase from Mycobacterium leprae (154 aa)%2CFASTA scores: opt: 928%2C E(): 2.1e-51%2C (90.25%25 identity in 154 aa overlap). Also highly similar to others e.g. O54134|DUT_STRCO|SC2E9.09 from Streptomyces coelicolor (183 aa)%2C FASTA scores: opt: 534%2C E(): 1.2e-26%2C (56.1%25 identity in 148 aa overlap)%3B O66592|DUT_AQUAE|AQ_220 from Aquifex aeolicus (150 aa)%2C FASTA scores: opt: 398%2C E(): 3.3e-18%2C(48.05%25 identity in 152 aa overlap)%3B Q9X3X5|DUT_ZYMMO from Zymomonas mobilis (146 aa)%2C FASTA scores: opt: 396%2C E(): 4.4e-18%2C (49.0%25 identity in 147 aa overlap)%3B etc. Belongs to the dUTPase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dut;locus_tag=Rv2697c;product=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase Dut (dUTPase) (dUTP pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dUTP diphosphatase) (deoxyuridine-triphosphatase);protein_id=CCP45495.1;transl_table=11
AL123456.3	EMBL	gene	3014173	3014658	.	+	.	ID=gene-Rv2698;Name=Rv2698;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2698
AL123456.3	EMBL	CDS	3014173	3014658	.	+	0	ID=cds-CCP45496.1;Parent=gene-Rv2698;Dbxref=EnsemblGenomes-Gn:Rv2698,EnsemblGenomes-Tr:CCP45496,GOA:I6X552,InterPro:IPR021443,UniProtKB/TrEMBL:I6X552,NCBI_GP:CCP45496.1;Name=CCP45496.1;Note=Rv2698%2C (MTCY05A6.19)%2C len: 161 aa. Probable conserved ala-rich transmembrane protein%2C equivalent to Q49991|ML1027|U1764I possible membrane protein from Mycobacterium leprae (157 aa)%2C FASTA scores: opt: 886%2C E(): 1.1e-49%2C (78.9%25 identity in 161 aa overlap). Also similar to O54132|SC2E9.07c hypothetical 16.5 KDA protein from Streptomyces coelicolor (154 aa)%2C FASTA scores: opt: 230%2CE(): 7.1e-08%2C (35.7%25 identity in 154 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2698;product=Probable conserved alanine rich transmembrane protein;protein_id=CCP45496.1;transl_table=11
AL123456.3	EMBL	gene	3014663	3014965	.	-	.	ID=gene-Rv2699c;Name=Rv2699c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2699c
AL123456.3	EMBL	CDS	3014663	3014965	.	-	0	ID=cds-CCP45497.1;Parent=gene-Rv2699c;Dbxref=EnsemblGenomes-Gn:Rv2699c,EnsemblGenomes-Tr:CCP45497,InterPro:IPR025242,UniProtKB/TrEMBL:I6YA17,NCBI_GP:CCP45497.1;Name=CCP45497.1;Note=Rv2699c%2C (MTCY05A6.20c)%2C len: 100 aa. Conserved hypothetical protein%2C very equivalent to Q49990|ML1026|U1764J hypothetical protein from Mycobacterium leprae (100 aa)%2C FASTA scores: opt: 632%2C E(): 7.7e-36%2C (96.0%25 identity in 100 aa overlap). Also highly similar to O54130|SC2E9.05 hypothetical 11.0 KDA protein from Streptomyces coelicolor (98 aa)%2C FASTA scores: opt: 465%2C E(): 1.1e-24%2C (71.45%25 identity in 98 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2699c;product=Conserved hypothetical protein;protein_id=CCP45497.1;transl_table=11
AL123456.3	EMBL	gene	3015203	3015853	.	+	.	ID=gene-Rv2700;Name=Rv2700;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2700
AL123456.3	EMBL	CDS	3015203	3015853	.	+	0	ID=cds-CCP45498.1;Parent=gene-Rv2700;Dbxref=EnsemblGenomes-Gn:Rv2700,EnsemblGenomes-Tr:CCP45498,InterPro:IPR027381,UniProtKB/TrEMBL:I6Y1I5,NCBI_GP:CCP45498.1;Name=CCP45498.1;Note=Rv2700%2C (MTCY05A6.21)%2C len: 216 aa. Possible secreted ala-rich protein%2C equivalent to Q4998|ML1025|U1764H possible secreted protein from Mycobacterium leprae (216 aa)%2C FASTA scores: opt: 1198%2CE(): 1.2e-65%2C (82.4%25 identity in 216 aa overlap). Also showing some similarity with Q9AK75|2SCD60.08c conserved hypothetical protein from Streptomyces coelicolor (204 aa)%2CFASTA scores: opt: 193%2C E(): 8.9e-05%2C (31.25%25 identity in 192 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2700;product=Possible conserved secreted alanine rich protein;protein_id=CCP45498.1;transl_table=11
AL123456.3	EMBL	gene	3015863	3016735	.	-	.	ID=gene-Rv2701c;Name=suhB;gbkey=Gene;gene=suhB;gene_biotype=protein_coding;locus_tag=Rv2701c
AL123456.3	EMBL	CDS	3015863	3016735	.	-	0	ID=cds-CCP45499.1;Parent=gene-Rv2701c;Dbxref=EnsemblGenomes-Gn:Rv2701c,EnsemblGenomes-Tr:CCP45499,GOA:P9WKI9,InterPro:IPR000760,InterPro:IPR020550,InterPro:IPR020583,PDB:2Q74,NCBI_GP:CCP45499.1;Name=CCP45499.1;Note=Rv2701c%2C (MTCY05A6.22c)%2C len: 290 aa. SuhB%2Cinositol-1-monophosphatase. Equivalent to AAK47090 from Mycobacterium tuberculosis strain CDC1551 (277 aa) but longer 13 aa. Contains PS00630 Inositol monophosphatase family signatures 1 and 2 (PS00629 and PS00630). Belongs to the inositol monophosphatase family. Cofactor: Mg2+. Activity is inhibited by Li+ but not when Leu81 is mutated (See Nigou et al.%2C 2002). Mg2+ promotes dimerization%3B Li+ amplifies this effect but does not promote dimerization on its own (See Brown et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=suhB;inference=protein motif:PROSITE:PS00630;locus_tag=Rv2701c;product=Inositol-1-monophosphatase SuhB;protein_id=CCP45499.1;transl_table=11
AL123456.3	EMBL	gene	3016858	3017655	.	+	.	ID=gene-Rv2702;Name=ppgK;gbkey=Gene;gene=ppgK;gene_biotype=protein_coding;locus_tag=Rv2702
AL123456.3	EMBL	CDS	3016858	3017655	.	+	0	ID=cds-CCP45500.1;Parent=gene-Rv2702;Dbxref=EnsemblGenomes-Gn:Rv2702,EnsemblGenomes-Tr:CCP45500,GOA:P9WIN1,InterPro:IPR000600,NCBI_GP:CCP45500.1;Name=CCP45500.1;Note=Rv2702%2C (MTCY05A6.23)%2C len: 265 aa. PpgK%2Cpolyphosphate glucokinase (see citations below)%2Cequivalent%2C but shorter 60 aa%2C to Q49988|PPGK_MYCLE|ML1023|U1764FG polyphosphate glucokinase from Mycobacterium leprae (324 aa)%2C FASTA scores: opt: 1411%2C E(): 5.6e-80%2C (82.8%25 identity in 262 aa overlap). Also highly similar (or just similar) to others e.g. Q9ADE8|PPGK from Streptomyces coelicolor (246 aa)%2C FASTA scores: opt: 912%2C E(): 3e-49%2C (57.3%25 identity in 239 aa overlap)%3B Q9AGV8|PPGK from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (277 aa)%2C FASTA scores: opt: 890%2C E(): 7.5e-48%2C (57.75%25 identity in 239 aa overlap)%3B P40184|GLK_STRCO|SC6E10.20c from Streptomyces coelicolor (317 aa)%2C FASTA scores: opt: 233%2C E(): 3.2e-07%2C (31.3%25 identity in 163 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppgK;locus_tag=Rv2702;product=Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase);protein_id=CCP45500.1;transl_table=11
AL123456.3	EMBL	gene	3017835	3019421	.	+	.	ID=gene-Rv2703;Name=sigA;gbkey=Gene;gene=sigA;gene_biotype=protein_coding;gene_synonym=mysA,rpoD,rpoV;locus_tag=Rv2703
AL123456.3	EMBL	CDS	3017835	3019421	.	+	0	ID=cds-CCP45501.1;Parent=gene-Rv2703;Dbxref=EnsemblGenomes-Gn:Rv2703,EnsemblGenomes-Tr:CCP45501,GOA:P9WGI1,InterPro:IPR000943,InterPro:IPR007624,InterPro:IPR007627,InterPro:IPR007630,InterPro:IPR009042,InterPro:IPR011991,InterPro:IPR012760,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,InterPro:IPR028630,NCBI_GP:CCP45501.1;Name=CCP45501.1;Note=Rv2703%2C (MTCY05A6.24)%2C len: 528 aa. SigA (formerly named mysA%2C and also known as rpoV or rpoD)%2C RNA polymerase sigma factor (see citations below)%2C equivalent (but shorter 55 aa) to Q9S5K3|RPOT (alias Q59532) RNA polymerase sigma factor from Mycobacterium leprae (576 aa)%2C FASTA scores: opt: 2638%2C E(): 8.6e-115%2C (80.35%25 identity in 535 aa overlap). Also similar to others e.g. Q59552|MYSA from Mycobacterium smegmatis (466 aa)%2C FASTA scores: opt: 2259%2CE(): 2.3e-97%2C (76.5%25 identity in 528 aa overlap)%3B Q45302|SIGA from Corynebacterium glutamicum (Brevibacterium flavum) (497 aa)%2C FASTA scores: opt: 1972%2C E(): 4.3e-84%2C(67.35%25 identity in 505 aa overlap)%3B Q59813|HRDB from Streptomyces aureofaciens (525 aa)%2C FASTA scores: opt: 1654%2C E(): 2.1e-69%2C (67.5%25 identity in 468 aa overlap)%3B etc. Contains sigma-70 family signatures 1 and 2 (PS00715 and PS00716). Belongs to the sigma-70 factor family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigA;inference=protein motif:PROSITE:PS00715;locus_tag=Rv2703;product=RNA polymerase sigma factor SigA (sigma-A);protein_id=CCP45501.1;transl_table=11
AL123456.3	EMBL	gene	3019458	3019886	.	+	.	ID=gene-Rv2704;Name=Rv2704;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2704
AL123456.3	EMBL	CDS	3019458	3019886	.	+	0	ID=cds-CCP45502.1;Parent=gene-Rv2704;Dbxref=EnsemblGenomes-Gn:Rv2704,EnsemblGenomes-Tr:CCP45502,InterPro:IPR006175,InterPro:IPR013813,UniProtKB/TrEMBL:I6YA21,NCBI_GP:CCP45502.1;Name=CCP45502.1;Note=Rv2704%2C (MTCY05A6.25)%2C len: 142 aa. Conserved protein%2C highly similar (but shorter 25 aa) to Q9RYB7|DR0033 conserved hypothetical protein from Deinococcus radiodurans (157 aa)%2C FASTA scores: opt: 381%2CE(): 1.5e-17%2C (54.85%25 identity in 124 aa overlap)%3B and highly similar to various proteins e.g. CAC47758|SMC03796 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (126 aa)%2C FASTA scores: opt: 302%2CE(): 1.4e-12%2C (46.6%25 identity in 126 aa overlap)%3B Q98E55|MLL4402 from Rhizobium loti (Mesorhizobium loti) (130 aa)%2C FASTA scores: opt: 252%2C E(): 2.1e-09%2C (40.15%25 identity in 127 aa overlap)%3B Q9K3V5|SCD10.21 putative acetyltransferase from Streptomyces coelicolor (291 aa)%2CFASTA scores: opt: 247%2C E(): 8.7e-09%2C (41.3%25 identity in 138 aa overlap) (homology only in N-terminal region)%3B etc. Belongs to the YJGF/YER057C/UK114 protein family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2704;product=Conserved protein;protein_id=CCP45502.1;transl_table=11
AL123456.3	EMBL	gene	3019814	3020203	.	-	.	ID=gene-Rv2705c;Name=Rv2705c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2705c
AL123456.3	EMBL	CDS	3019814	3020203	.	-	0	ID=cds-CCP45503.1;Parent=gene-Rv2705c;Dbxref=EnsemblGenomes-Gn:Rv2705c,EnsemblGenomes-Tr:CCP45503,InterPro:IPR009297,UniProtKB/TrEMBL:O07206,NCBI_GP:CCP45503.1;Name=CCP45503.1;Note=Rv2705c%2C (MTCY05A6.26c)%2C len: 129 aa (unlikely ORF). Conserved hypothetical protein%2C similar to others e.g. Q9RXR5|DR0242 conserved hypothetical protein from Deinococcus radiodurans (112 aa)%2C FASTA scores: opt: 259%2CE(): 9.4e-10%2C (40.5%25 identity in 116 aa overlap)%3B CAC45122|SMC02246 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (115 aa)%2C FASTA scores: opt: 208%2C E(): 1.6e-06%2C (38.3%25 identity in 107 aa overlap)%3B Q98B88|MLL5682 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (116 aa)%2C FASTA scores: opt: 173%2C E(): 0.00026%2C (34.95%25 identity in 103 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2705c;product=Conserved hypothetical protein;protein_id=CCP45503.1;transl_table=11
AL123456.3	EMBL	gene	3020200	3020457	.	-	.	ID=gene-Rv2706c;Name=Rv2706c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2706c
AL123456.3	EMBL	CDS	3020200	3020457	.	-	0	ID=cds-CCP45504.1;Parent=gene-Rv2706c;Dbxref=EnsemblGenomes-Gn:Rv2706c,EnsemblGenomes-Tr:CCP45504,UniProtKB/TrEMBL:O07207,NCBI_GP:CCP45504.1;Name=CCP45504.1;Note=Rv2706c%2C (MTCY05A6.27c)%2C len: 85 aa (unlikely ORF). Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2706c;product=Hypothetical protein;protein_id=CCP45504.1;transl_table=11
AL123456.3	EMBL	gene	3020573	3021547	.	+	.	ID=gene-Rv2707;Name=Rv2707;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2707
AL123456.3	EMBL	CDS	3020573	3021547	.	+	0	ID=cds-CCP45505.1;Parent=gene-Rv2707;Dbxref=EnsemblGenomes-Gn:Rv2707,EnsemblGenomes-Tr:CCP45505,GOA:I6YE67,InterPro:IPR017039,UniProtKB/TrEMBL:I6YE67,NCBI_GP:CCP45505.1;Name=CCP45505.1;Note=Rv2707%2C (MTCY05A6.28)%2C len: 324 aa. Probable conserved transmembrane ala-%2C leu-rich protein%2C equivalent to Q49985|ML1017|U1764D possible conserved integral membrane protein from Mycobacterium leprae (330 aa)%2C FASTA scores: opt: 1617%2C E(): 2.5e-91%2C (75.4%25 identity in 325 aa overlap). Also similar to other membrane proteins e.g. Q9ADF6|SCBAC1A6.31 putative integral membrane protein from Streptomyces coelicolor (344 aa)%2C FASTA scores: opt: 593%2CE(): 5.9e-29%2C (36.2%25 identity in 268 aa overlap)%3B Q99SZ8|SA1699 hypothetical protein (similar to transporter) from Staphylococcus aureus subsp. aureus N315 (405 aa)%2CFASTA scores: opt: 318%2C E(): 3.7e-12%2C (27.9%25 identity in 265 aa overlap)%3B O34437|YFKH hypothetical protein (similar to transporter) from Bacillus subtilis (275 aa)%2C FASTA scores: opt: 309%2C E(): 9.7e-12%2C (29.3%25 identity in 263 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2707;product=Probable conserved transmembrane alanine and leucine rich protein;protein_id=CCP45505.1;transl_table=11
AL123456.3	EMBL	gene	3021548	3021796	.	-	.	ID=gene-Rv2708c;Name=Rv2708c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2708c
AL123456.3	EMBL	CDS	3021548	3021796	.	-	0	ID=cds-CCP45506.1;Parent=gene-Rv2708c;Dbxref=EnsemblGenomes-Gn:Rv2708c,EnsemblGenomes-Tr:CCP45506,InterPro:IPR021400,UniProtKB/TrEMBL:I6X562,NCBI_GP:CCP45506.1;Name=CCP45506.1;Note=Rv2708c%2C (MTCY05A6.29)%2C len: 82 aa. Conserved hypothetical protein%2C equivalent (but shorter 25 aa) to Q49984|ML1016|U1764C hypothetical protein from Mycobacterium leprae (107 aa)%2C FASTA scores: opt: 492%2C E(): 7.3e-27%2C (87.8%25 identity in 82 aa overlap). Also highly similar to Q9L1U7|SCE59.06c hypothetical 10.4 KDA protein from Streptomyces coelicolor (97 aa)%2C FASTA scores: opt: 200%2C E(): 4.4e-07%2C (51.6%25 identity in 62 aa overlap).;gbkey=CDS;locus_tag=Rv2708c;product=Conserved hypothetical protein;protein_id=CCP45506.1;transl_table=11
AL123456.3	EMBL	gene	3021839	3022285	.	+	.	ID=gene-Rv2709;Name=Rv2709;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2709
AL123456.3	EMBL	CDS	3021839	3022285	.	+	0	ID=cds-CCP45507.1;Parent=gene-Rv2709;Dbxref=EnsemblGenomes-Gn:Rv2709,EnsemblGenomes-Tr:CCP45507,GOA:I6YA25,InterPro:IPR021449,UniProtKB/TrEMBL:I6YA25,NCBI_GP:CCP45507.1;Name=CCP45507.1;Note=Rv2709%2C (MTCY05A6.30)%2C len: 148 aa. Probable conserved transmembrane protein%2C equivalent to Q9CCB4|ML1015 (alias Q49983|U1764B but extended in N-terminus) possible conserved membrane protein from Mycobacterium leprae (139 aa)%2C FASTA scores: opt: 578%2C E(): 5.5e-31%2C (70.75%25 identity in 123 aa overlap). Shows also similarity with Q9RJ48|SCI8.05 putative integral membrane protein from Streptomyces coelicolor (159 aa)%2C FASTA scores: opt: 119%2C E(): 0.57%2C (31.95%25 identity in 119 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2709;product=Probable conserved transmembrane protein;protein_id=CCP45507.1;transl_table=11
AL123456.3	EMBL	gene	3022461	3023432	.	+	.	ID=gene-Rv2710;Name=sigB;gbkey=Gene;gene=sigB;gene_biotype=protein_coding;gene_synonym=mysB;locus_tag=Rv2710
AL123456.3	EMBL	CDS	3022461	3023432	.	+	0	ID=cds-CCP45508.1;Parent=gene-Rv2710;Dbxref=EnsemblGenomes-Gn:Rv2710,EnsemblGenomes-Tr:CCP45508,GOA:P9WGI5,InterPro:IPR000943,InterPro:IPR007624,InterPro:IPR007627,InterPro:IPR007630,InterPro:IPR009042,InterPro:IPR011991,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,NCBI_GP:CCP45508.1;Name=CCP45508.1;Note=Rv2710%2C (MTCY05A6.31)%2C len: 323 aa. SigB (formerly known as mysB)%2C RNA polymerase sigma factor (see citations below)%2C equivalent to Q59531|ML1014 RNA polymerase sigma factor from Mycobacterium leprae (319 aa)%2C FASTA scores: opt: 1935%2C E(): 1.9e-109%2C (96.2%25 identity in 316 aa overlap). Also highly similar to others e.g. Q59553|MYSB from Mycobacterium smegmatis (319 aa)%2C FASTA scores: opt: 1874%2C E(): 9.1e-106%2C (92.4%25 identity in 316 aa overlap)%3B Q9ANT6|SIGB from Brevibacterium flavum (331 aa)%2C FASTA scores: opt: 1525%2C E(): 9.9e-85%2C (78.9%25 identity in 303 aa overlap)%3B Q60158|RPOV from Mycobacterium bovis (528 aa)%2CFASTA scores: opt: 1246%2C E(): 9.3e-68%2C (62.85%25 identity in 315 aa overlap)%3B etc. Contains sigma-70 factors family signatures 1 and 2 (PS00715 and PS00716). And contains possible helix-turn-helix motif at aa 282-303 (Score 1887%2C+5.61 SD). Belongs to the sigma-70 factor family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigB;inference=protein motif:PROSITE:PS00715;locus_tag=Rv2710;product=RNA polymerase sigma factor SigB;protein_id=CCP45508.1;transl_table=11
AL123456.3	EMBL	gene	3023565	3024257	.	+	.	ID=gene-Rv2711;Name=ideR;gbkey=Gene;gene=ideR;gene_biotype=protein_coding;gene_synonym=dtxR;locus_tag=Rv2711
AL123456.3	EMBL	CDS	3023565	3024257	.	+	0	ID=cds-CCP45509.1;Parent=gene-Rv2711;Dbxref=EnsemblGenomes-Gn:Rv2711,EnsemblGenomes-Tr:CCP45509,GOA:P9WMH1,InterPro:IPR001367,InterPro:IPR007167,InterPro:IPR008988,InterPro:IPR011991,InterPro:IPR022687,InterPro:IPR022689,PDB:1B1B,PDB:1FX7,PDB:1U8R,PDB:2ISY,PDB:2ISZ,PDB:2IT0,NCBI_GP:CCP45509.1;Name=CCP45509.1;Note=Rv2711%2C (MTCY05A6.32)%2C len: 230 aa. IdeR (formerly known as dtxR)%2C iron dependent repressor and activator (see citations below)%2C equivalent to Q9CCB5|ML1013 iron dependent repressor from Mycobacterium leprae (230 aa)%2CFASTA scores: opt: 1365%2C E(): 3.8e-77%2C (90.0%25 identity in 230 aa overlap). Also highly similar to others e.g. Q50379|DTXR from Mycobacterium smegmatis (233 aa)%2C FASTA scores: opt: 1291%2C E(): 1.4e-72%2C (86.1%25 identity in 230 aa overlap)%3B Q9F7T3|IDER from Corynebacterium equii (Rhodococcus equi) (230 aa)%2C FASTA scores: opt: 1130%2C E(): 1.2e-62%2C (74.8%25 identity in 230 aa overlap)%3B P33120|DTXR_CORDI from Corynebacterium diphtheriae (226 aa)%2C FASTA scores: opt: 803%2C E(): 1.6e-42%2C (57.85%25 identity in 230 aa overlap)%3B etc. Belongs to the fur family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ideR;inference=protein motif:PROSITE:PS00142;locus_tag=Rv2711;product=Iron-dependent repressor and activator IdeR;protein_id=CCP45509.1;transl_table=11
AL123456.3	EMBL	gene	3024270	3025328	.	-	.	ID=gene-Rv2712c;Name=Rv2712c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2712c
AL123456.3	EMBL	CDS	3024270	3025328	.	-	0	ID=cds-CCP45510.1;Parent=gene-Rv2712c;Dbxref=EnsemblGenomes-Gn:Rv2712c,EnsemblGenomes-Tr:CCP45510,InterPro:IPR025447,UniProtKB/TrEMBL:I6YE70,NCBI_GP:CCP45510.1;Name=CCP45510.1;Note=Rv2712c%2C (MTCY05A6.33c)%2C len: 352 aa. Hypothetical unknown ala-%2C leu-rich protein.;gbkey=CDS;locus_tag=Rv2712c;product=Hypothetical protein;protein_id=CCP45510.1;transl_table=11
AL123456.3	EMBL	gene	3025441	3026847	.	+	.	ID=gene-Rv2713;Name=sthA;gbkey=Gene;gene=sthA;gene_biotype=protein_coding;locus_tag=Rv2713
AL123456.3	EMBL	CDS	3025441	3026847	.	+	0	ID=cds-CCP45511.1;Parent=gene-Rv2713;Dbxref=EnsemblGenomes-Gn:Rv2713,EnsemblGenomes-Tr:CCP45511,GOA:P9WHH5,InterPro:IPR001327,InterPro:IPR004099,InterPro:IPR013027,InterPro:IPR016156,InterPro:IPR022962,InterPro:IPR023753,NCBI_GP:CCP45511.1;Name=CCP45511.1;Note=Rv2713%2C (MT2786%2C MTCY05A6.34)%2C len: 468 aa. Probable sthA%2C soluble pyridine nucleotide transhydrogenase%2C highly similar to others e.g. Q983E2|MLR8366 from Rhizobium loti (Mesorhizobium loti) (481 aa)%2C FASTA scores: opt: 1447%2CE(): 4.1e-78%2C (49.55%25 identity in 460 aa overlap)%3B P27306|STHA_ECOLI|STH|UDHA|B3962 from Escherichia coli strain K12 (465 aa)%2C FASTA scores: opt: 1267%2C E(): 1.7e-67%2C(43.05%25 identity in 462 aa overlap)%3B O05139|STHA_PSEFL|STH from Pseudomonas fluorescens (463 aa)%2C FASTA scores: opt: 1257%2C E(): 6.6e-67%2C (43.8%25 identity in 461 aa overlap)%3B etc. Also highly similar to CAC46308|SMC00300 putative oxidoreductase protein from Rhizobium meliloti (Sinorhizobium meliloti) (467 aa)%2C FASTA scores: opt: 1466%2CE(): 3e-79%2C (49.55%25 identity in 462 aa overlap). Shows some similarity to MTCY359.04%2C E(): 3.1e-08%3B MTCY210.05%2C E(): 3.4e-08. Contains ATP/GTP-binding site motif A (P-loop%3B PS00017). Belongs to the pyridine nucleotide-disulfide oxidoreductases class-I. Cofactor: FAD (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sthA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2713;product=Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleotide transhydrogenase);protein_id=CCP45511.1;transl_table=11
AL123456.3	EMBL	gene	3027065	3028039	.	+	.	ID=gene-Rv2714;Name=Rv2714;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2714
AL123456.3	EMBL	CDS	3027065	3028039	.	+	0	ID=cds-CCP45512.1;Parent=gene-Rv2714;Dbxref=EnsemblGenomes-Gn:Rv2714,EnsemblGenomes-Tr:CCP45512,GOA:I6YA29,InterPro:IPR008492,InterPro:IPR013028,InterPro:IPR019151,UniProtKB/TrEMBL:I6YA29,NCBI_GP:CCP45512.1;Name=CCP45512.1;Note=Rv2714%2C (MTCY05A6.35)%2C len: 324 aa. Conserved ala-%2Cleu-rich protein%2C equivalent to Q49847|ML1009|B2235_F1_6 hypothetical protein from Mycobacterium leprae (326 aa)%2CFASTA scores: opt: 1881%2C E(): 5.8e-107%2C (89.7%25 identity in 320 aa overlap)%3B and similar to Q49797|MLCB2533.03c|B2126_F1_36 hypothetical protein from Mycobacterium leprae (317 aa)%2C FASTA scores: opt: 376%2C E(): 1.2e-15%2C (30.1%25 identity in 279 aa overlap)%3B and Q9CC38|ML1306 hypothetical protein from Mycobacterium leprae (274 aa)%2C FASTA scores: opt: 367%2C E(): 3.6e-15%2C(29.8%25 identity in 275 aa overlap). Also highly similar to Q9S2K6|SC7H2.11c hypothetical 34.2 KDA protein from Streptomyces coelicolor (312 aa)%2C FASTA scores: opt: 770%2CE(): 1.4e-39%2C (40.9%25 identity in 286 aa overlap)%3B and similar to Q9ADA5|SCI52.04 conserved hypothetical protein from Streptomyces coelicolor (333 aa)%2C FASTA scores: opt: 386%2C E(): 3e-16%2C (29.05%25 identity in 296 aa overlap). Also similar to O33260|Rv2125|MTCY261.21 hypothetical protein from Mycobacterium tuberculosis (292 aa)%2C FASTA scores: opt: 387%2C E(): 2.3e-16%2C (29.45%25 identity in 292 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2714;product=Conserved alanine and leucine rich protein;protein_id=CCP45512.1;transl_table=11
AL123456.3	EMBL	gene	3028098	3029123	.	+	.	ID=gene-Rv2715;Name=Rv2715;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2715
AL123456.3	EMBL	CDS	3028098	3029123	.	+	0	ID=cds-CCP45513.1;Parent=gene-Rv2715;Dbxref=EnsemblGenomes-Gn:Rv2715,EnsemblGenomes-Tr:CCP45513,GOA:P9WNH3,InterPro:IPR000073,InterPro:IPR000639,InterPro:IPR029058,NCBI_GP:CCP45513.1;Name=CCP45513.1;Note=Rv2715%2C (MTCY05A6.36)%2C len: 341 aa. Possible hydrolase%2C showing some similarity with other hydrolases e.g. Q9I5B0|PA0829 probable hydrolase from Pseudomonas aeruginosa (313 aa)%2C FASTA scores: opt: 336%2C E(): 9.9e-14%2C(28.05%25 identity in 289 aa overlap)%3B BAB55888 hydrolase (fragment) from Terrabacter sp. DBF63 (319 aa)%2C FASTA scores: opt: 326%2C E(): 4.2e-13%2C (27.95%25 identity in 290 aa overlap)%3B O52866|CEH|eh soluble epoxide hydrolase from Corynebacterium SP (285 aa)%2C FASTA scores: opt: 325%2C E(): 4.4e-13%2C (29.95%25 identity in 284 aa overlap)%3B etc. Also shows some similarity to P96811|EPHF|Rv0134|MTCI5.08 hypothetical 33.8 KDA protein from Mycobacterium tuberculosis (300 aa)%2C FASTA scores: E(): 1.8e-10%2C (27.7%25 identity in 271 aa overlap). Contains lipases%2C serine active site motif (PS00120).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv2715;product=Possible hydrolase;protein_id=CCP45513.1;transl_table=11
AL123456.3	EMBL	gene	3029172	3029858	.	+	.	ID=gene-Rv2716;Name=Rv2716;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2716
AL123456.3	EMBL	CDS	3029172	3029858	.	+	0	ID=cds-CCP45514.1;Parent=gene-Rv2716;Dbxref=EnsemblGenomes-Gn:Rv2716,EnsemblGenomes-Tr:CCP45514,GOA:P9WL43,InterPro:IPR003719,NCBI_GP:CCP45514.1;Name=CCP45514.1;Note=Rv2716%2C (MTCY05A6.37)%2C len: 228 aa. Conserved protein%2C similar to other proteins e.g. Q9RKR0|SCC75A.14 hypothetical 23.3 KDA protein from Streptomyces coelicolor (214 aa)%2C FASTA scores: opt: 447%2C E(): 4e-22%2C (44.1%25 identity in 220 aa overlap)%3B Q9HHG6|PHZF|VNG6408G phenazine biosynthetic protein from Halobacterium sp. strain NRC-1 (299 aa)%2C FASTA scores: opt: 201%2C E(): 6.1e-06%2C (30.4%25 identity in 148 aa overlap) (similarity only at N-terminus)%3B P73125|SLR1019 hypothetical 34.1 KDA protein from Synechocystis sp. strain PCC 6803 (314 aa)%2C FASTA scores: opt: 196%2C E(): 1.4e-05%2C (28.5%25 identity in 298 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2716;product=Conserved protein;protein_id=CCP45514.1;transl_table=11
AL123456.3	EMBL	gene	3029867	3030361	.	-	.	ID=gene-Rv2717c;Name=Rv2717c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2717c
AL123456.3	EMBL	CDS	3029867	3030361	.	-	0	ID=cds-CCP45515.1;Parent=gene-Rv2717c;Dbxref=EnsemblGenomes-Gn:Rv2717c,EnsemblGenomes-Tr:CCP45515,GOA:P9WFG7,InterPro:IPR011038,InterPro:IPR014878,InterPro:IPR022939,PDB:2FR2,NCBI_GP:CCP45515.1;Name=CCP45515.1;Note=Rv2717c%2C (MTCY05A6.38c)%2C len: 164 aa. Conserved protein%2C equivalent to Q9CCB8|ML1006 (alias Q49838 but shortened N-terminus) hypothetical protein from Mycobacterium leprae (161 aa)%2C FASTA scores: opt: 797%2C E(): 2.3e-46%2C (73.8%25 identity in 164 aa overlap). Also highly similar to other eukaryotic proteins e.g. O64527|YUP8H12R.14 hypothetical protein from Arabidopsis thaliana (Mouse-ear cress) (166 aa)%2C FASTA scores: opt: 393%2C E(): 2.3e-19%2C (42.4%25 identity in 158 aa overlap)%3B Q9Y325 CGI-36 protein from Homo sapiens (Human) (165 aa)%2CFASTA scores: opt: 294%2C E(): 9.5e-13%2C (33.95%25 identity in 159 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2717c;product=Conserved protein;protein_id=CCP45515.1;transl_table=11
AL123456.3	EMBL	gene	3030413	3030877	.	-	.	ID=gene-Rv2718c;Name=nrdR;gbkey=Gene;gene=nrdR;gene_biotype=protein_coding;locus_tag=Rv2718c
AL123456.3	EMBL	CDS	3030413	3030877	.	-	0	ID=cds-CCP45516.1;Parent=gene-Rv2718c;Dbxref=EnsemblGenomes-Gn:Rv2718c,EnsemblGenomes-Tr:CCP45516,GOA:P9WIZ1,InterPro:IPR003796,InterPro:IPR005144,NCBI_GP:CCP45516.1;Name=CCP45516.1;Note=Rv2718c%2C (MTCY05A6.39c)%2C len: 154 aa. Probable nrdR%2Ctranscriptional regulatory protein%2C equivalent to Q49844|ML1005|U2235A|B2235_C2_209 hypothetical 17.3 KDA protein from Mycobacterium leprae (154 aa)%2C FASTA scores: opt: 937%2C E(): 1.5e-52%2C (92.7%25 identity in 151 aa overlap). Highly similar to O86848|NRDR_STRCL putative regulatory protein from Streptomyces clavuligerus (172 aa)%2C FASTA scores: opt: 750%2C E(): 1.1e-40%2C (73.65%25 identity in 148 aa overlap)%3B O69980|SC4H2.25 hypothetical protein from Streptomyces coelicolor (182 aa)%2C FASTA scores: opt: 725%2CE(): 4.6e-39%2C (73.1%25 identity in 145 aa overlap)%3B Q9KPU0|VC2272 hypothetical protein from Vibrio cholerae (156 aa)%2C FASTA scores: opt: 462%2C E(): 1.8e-22%2C (47.3%25 identity in 148 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrdR;locus_tag=Rv2718c;product=Probable transcriptional regulatory protein NrdR;protein_id=CCP45516.1;transl_table=11
AL123456.3	EMBL	gene	3031040	3031537	.	-	.	ID=gene-Rv2719c;Name=Rv2719c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2719c
AL123456.3	EMBL	CDS	3031040	3031537	.	-	0	ID=cds-CCP45517.1;Parent=gene-Rv2719c;Dbxref=EnsemblGenomes-Gn:Rv2719c,EnsemblGenomes-Tr:CCP45517,GOA:I6YA32,InterPro:IPR018392,UniProtKB/TrEMBL:I6YA32,NCBI_GP:CCP45517.1;Name=CCP45517.1;Note=Rv2719c%2C (MTCY05A6.40c)%2C len: 165 aa. Possible conserved membrane protein%2C equivalent to Q49846|ML1004|B2235_C3_243 possible conserved membrane protein from Mycobacterium leprae (164 aa)%2C FASTA scores: opt: 486%2C E(): 4e-21%2C (55.2%25 identity in 163 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2719c;product=Possible conserved membrane protein;protein_id=CCP45517.1;transl_table=11
AL123456.3	EMBL	gene	3031788	3032498	.	+	.	ID=gene-Rv2720;Name=lexA;gbkey=Gene;gene=lexA;gene_biotype=protein_coding;locus_tag=Rv2720
AL123456.3	EMBL	CDS	3031788	3032498	.	+	0	ID=cds-CCP45518.1;Parent=gene-Rv2720;Dbxref=EnsemblGenomes-Gn:Rv2720,EnsemblGenomes-Tr:CCP45518,GOA:P9WHR7,InterPro:IPR006197,InterPro:IPR006199,InterPro:IPR006200,InterPro:IPR011991,InterPro:IPR015927,InterPro:IPR019759,InterPro:IPR028360,NCBI_GP:CCP45518.1;Name=CCP45518.1;Note=Rv2720%2C (MTCY05A6.41)%2C len: 236 aa. LexA repressor (see citations below)%2C equivalent to Q49848|LEXA_MYCLE|ML1003|B2235_F2_55 LEXA repressor from Mycobacterium leprae (217 aa)%2C FASTA scores: opt: 1255%2CE(): 7.1e-70%2C (89.8%25 identity in 216 aa overlap). Also highly similar to others e.g. O69979|LEXA_STRCO|SC4H2.24c from Streptomyces coelicolor (234 aa)%2C FASTA scores: opt: 1034%2C E(): 2.6e-56%2C (70.5%25 identity in 217 aa overlap)%3B O86847|LEXA_STRCL from Streptomyces clavuligerus (239 aa)%2CFASTA scores: opt: 1021%2C E(): 1.6e-55%2C (69.1%25 identity in 217 aa overlap)%3B Q9KAD3|LEXA_BACHD from Bacillus halodurans (207 aa)%2C FASTA scores: opt: 645%2C E(): 1.5e-32%2C (47.9%25 identity in 213 aa overlap)%3B etc. Belongs to peptidase family S24%3B also known as the UMUD/LEXA family. Start changed since first submission (+19 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lexA;locus_tag=Rv2720;product=Repressor LexA;protein_id=CCP45518.1;transl_table=11
AL123456.3	EMBL	gene	3032520	3034619	.	-	.	ID=gene-Rv2721c;Name=Rv2721c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2721c
AL123456.3	EMBL	CDS	3032520	3034619	.	-	0	ID=cds-CCP45519.1;Parent=gene-Rv2721c;Dbxref=EnsemblGenomes-Gn:Rv2721c,EnsemblGenomes-Tr:CCP45519,GOA:I6XF52,InterPro:IPR013207,UniProtKB/TrEMBL:I6XF52,NCBI_GP:CCP45519.1;Name=CCP45519.1;Note=Rv2721c%2C (MTCY05A6.42c%2C MTCY154.01c)%2C len: 699 aa. Possible conserved transmembrane ala-%2C gly-rich protein%2Cequivalent to Q49837|ML1002|U2235I possible conserved membrane protein from Mycobacterium leprae (687 aa)%2C FASTA scores: opt: 2703%2C E(): 6.6e-135%2C (60.3%25 identity in 713 aa overlap). Shows some similaity to Q01377|CSP1 PS1 protein precursor (secreted protein) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa)%2C FASTA scores: opt: 276%2C E(): 3.8e-07%2C (29.4%25 identity in 272 aa overlap)%3B and Q9KIJ0 Rv2721c-like protein from Mycobacterium paratuberculosis (246 aa)%2C FASTA scores: opt: 178%2C E(): 0.025%2C (37.5%25 identity in 120 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2721c;product=Possible conserved transmembrane alanine and glycine rich protein;protein_id=CCP45519.1;transl_table=11
AL123456.3	EMBL	gene	3034635	3034883	.	+	.	ID=gene-Rv2722;Name=Rv2722;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2722
AL123456.3	EMBL	CDS	3034635	3034883	.	+	0	ID=cds-CCP45520.1;Parent=gene-Rv2722;Dbxref=EnsemblGenomes-Gn:Rv2722,EnsemblGenomes-Tr:CCP45520,UniProtKB/TrEMBL:O33227,NCBI_GP:CCP45520.1;Name=CCP45520.1;Note=Rv2722%2C (MTCY154.02)%2C len: 82 aa. Conserved hypothetical protein%2C similar to Q9CCB9|ML1001 hypothetical protein from Mycobacterium leprae (91 aa)%2C FASTA scores: opt: 154%2C E(): 0.00053%2C (37.5%25 identity in 88 aa overlap). Equivalent to AAK47111 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but shorter 12 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2722;product=Conserved hypothetical protein;protein_id=CCP45520.1;transl_table=11
AL123456.3	EMBL	gene	3034909	3036102	.	+	.	ID=gene-Rv2723;Name=Rv2723;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2723
AL123456.3	EMBL	CDS	3034909	3036102	.	+	0	ID=cds-CCP45521.1;Parent=gene-Rv2723;Dbxref=EnsemblGenomes-Gn:Rv2723,EnsemblGenomes-Tr:CCP45521,GOA:P9WG93,InterPro:IPR005496,InterPro:IPR022369,NCBI_GP:CCP45521.1;Name=CCP45521.1;Note=Rv2723%2C (MTCY154.03)%2C len: 397 aa. Probable conserved integral membrane protein%2C highly similar to others e.g. Q9Z503|SCC54.23c putative integral membrane export protein from Streptomyces coelicolor (333 aa)%2C FASTA scores: opt: 883%2C E(): 2.4e-48%2C (46.4%25 identity in 332 aa overlap)%3B Q9RD18|SCM1.25c putative integral membrane protein from Streptomyces coelicolor (316 aa)%2C FASTA scores: opt: 865%2C E(): 3.1e-47%2C (47.55%25 identity in 324 aa overlap)%3B P96554|Y319_MYXXA integral membrane protein (probable) from Myxococcus xanthus (319 aa)%2C FASTA scores: opt: 626%2C E(): 3.4e-32%2C (34.65%25 identity in 323 aa overlap)%3B P42601|YGJT_ECOLI|B3088 from Escherichia coli strain K12 integral membrane protein (probable) (321 aa)%2CFASTA scores: opt: 541%2C E(): 7.7e-27%2C (35.1%25 identity in 279 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2723;product=Probable conserved integral membrane protein;protein_id=CCP45521.1;transl_table=11
AL123456.3	EMBL	gene	3036131	3037291	.	-	.	ID=gene-Rv2724c;Name=fadE20;gbkey=Gene;gene=fadE20;gene_biotype=protein_coding;locus_tag=Rv2724c
AL123456.3	EMBL	CDS	3036131	3037291	.	-	0	ID=cds-CCP45522.1;Parent=gene-Rv2724c;Dbxref=EnsemblGenomes-Gn:Rv2724c,EnsemblGenomes-Tr:CCP45522,GOA:O33229,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:O33229,NCBI_GP:CCP45522.1;Name=CCP45522.1;Note=Rv2724c%2C (MTCY154.04c)%2C len: 386 aa. Probable fadE20%2C acyl-CoA dehydrogenase%2C highly similar to many e.g. Q9X7Y2|SC6A5.36 from Streptomyces coelicolor (382 aa)%2CFASTA scores: opt: 1583%2C E(): 6.9e-94%2C (62.7%25 identity in 378 aa overlap)%3B Q9HVY0|PA4435 from Pseudomonas aeruginosa (381 aa)%2C FASTA scores: opt: 1468%2C E(): 1.6e-86%2C (57.65%25 identity in 380 aa overlap)%3B Q9ABZ1|CC0079 from Caulobacter crescentus (391 aa)%2C FASTA scores: opt: 1298%2C E(): 1.2e-75%2C(51.9%25 identity in 391 aa overlap)%3B etc. Also similar to many other Mycobacterium tuberculosis proteins e.g. O06164|FADE19|Rv2500c|MTCY07A7.06c acyl-CoA dehydrogenase (394 aa) (34.3%25 identity in 382 aa overlap). Contains acyl-CoA dehydrogenases signature 2 (PS00073). Belongs to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE20;inference=protein motif:PROSITE:PS00073;locus_tag=Rv2724c;product=Probable acyl-CoA dehydrogenase FadE20;protein_id=CCP45522.1;transl_table=11
AL123456.3	EMBL	gene	3037427	3038914	.	-	.	ID=gene-Rv2725c;Name=hflX;gbkey=Gene;gene=hflX;gene_biotype=protein_coding;locus_tag=Rv2725c
AL123456.3	EMBL	CDS	3037427	3038914	.	-	0	ID=cds-CCP45523.1;Parent=gene-Rv2725c;Dbxref=EnsemblGenomes-Gn:Rv2725c,EnsemblGenomes-Tr:CCP45523,GOA:O33230,InterPro:IPR006073,InterPro:IPR016496,InterPro:IPR025121,InterPro:IPR027417,UniProtKB/TrEMBL:O33230,NCBI_GP:CCP45523.1;Name=CCP45523.1;Note=Rv2725c%2C (MTCY154.05c)%2C len: 495 aa. Probable hflX (hfl for high frequency of lysogenization)%2C GTP-binding protein %2Cequivalent to Q9CCC0|ML0997 (alias Q49843|HFLX but longer) possible ATP/GTP-binding protein from Mycobacterium leprae (488 aa)%2C FASTA scores: opt: 2562%2C E(): 1.1e-133%2C(84.55%25 identity in 485 aa overlap). Also highly similar to many e.g. Q9XCC1 from Streptomyces fradiae (425 aa)%2C FASTA scores: opt: 1280%2C E(): 3.2e-63%2C (57.7%25 identity in 423 aa overlap)%3B P73965|HFLX|SLR1521 from Synechocystis sp. strain PCC 6803 (534 aa)%2C FASTA scores: opt: 1028%2C E(): 2.8e-49%2C(44.7%25 identity in 414 aa overlap)%3B P25519|HFLX_ECOLI|B4173 from Escherichia coli strain K12 (426 aa)%2C FASTA scores: opt: 916%2C E(): 3.4e-43%2C (40.1%25 identity in 414 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hflX;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2725c;product=Probable GTP-binding protein HflX;protein_id=CCP45523.1;transl_table=11
AL123456.3	EMBL	gene	3038931	3039800	.	-	.	ID=gene-Rv2726c;Name=dapF;gbkey=Gene;gene=dapF;gene_biotype=protein_coding;locus_tag=Rv2726c
AL123456.3	EMBL	CDS	3038931	3039800	.	-	0	ID=cds-CCP45524.1;Parent=gene-Rv2726c;Dbxref=EnsemblGenomes-Gn:Rv2726c,EnsemblGenomes-Tr:CCP45524,GOA:P9WP19,InterPro:IPR001653,InterPro:IPR018510,PDB:3FVE,NCBI_GP:CCP45524.1;Name=CCP45524.1;Note=Rv2726c%2C (MTCY154.06c)%2C len: 289 aa. Probable dapF%2Cdiaminopimelate epimerase%2C equivalent to P46814|DAPF_MYCLE|ML0996|B2235_C3_233 diaminopimelate epimerase from Mycobacterium leprae (296 aa)%2C FASTA scores: opt: 1488%2C E(): 2.1e-83%2C (76.05%25 identity in 292 aa overlap). Also highly similar to O69969|DAPF_STRCO|SC4H2.14 from Streptomyces coelicolor (289 aa)%2C FASTA scores: opt: 439%2C E(): 1.4e-19%2C (45.6%25 identity in 296 aa overlap)%3B and similar to many e.g. O29511|DAPF_ARCFU|AF0747 from Archaeoglobus fulgidus (280 aa)%2C FASTA scores: opt: 310%2CE(): 9.7e-12%2C (33.8%25 identity in 296 aa overlap)%3B Q51564|DAPF_PSEAE|PA5278 from Pseudomonas aeruginosa (276 aa)%2C FASTA scores: opt: 272%2C E(): 2e-09%2C (30.15%25 identity in 292 aa overlap)%3B P08885|DAPF_ECOLI|B3809 from Escherichia coli strain K12 (274 aa)%2C FASTA scores: opt: 266%2C E(): 4.5e-09%2C (30.4%25 identity in 296 aa overlap)%3B etc. Belongs to the diaminopimelate epimerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dapF;locus_tag=Rv2726c;product=Probable diaminopimelate epimerase DapF (DAP epimerase);protein_id=CCP45524.1;transl_table=11
AL123456.3	EMBL	gene	3039825	3040769	.	-	.	ID=gene-Rv2727c;Name=miaA;gbkey=Gene;gene=miaA;gene_biotype=protein_coding;locus_tag=Rv2727c
AL123456.3	EMBL	CDS	3039825	3040769	.	-	0	ID=cds-CCP45525.1;Parent=gene-Rv2727c;Dbxref=EnsemblGenomes-Gn:Rv2727c,EnsemblGenomes-Tr:CCP45525,GOA:P9WJW1,InterPro:IPR002627,InterPro:IPR018022,InterPro:IPR027417,NCBI_GP:CCP45525.1;Name=CCP45525.1;Note=Rv2727c%2C (MTCY154.07c)%2C len: 314 aa. Probable miaA%2CtRNA delta(2)-isopentenylpyrophosphate transferase%2Cequivalent to P46811|MIAA_MYCLE|ML0995|B2235_C3_232 tRNA delta(2)-isopentenylpyrophosphate transferase from Mycobacterium leprae (311 aa)%2C FASTA scores: opt: 1679%2CE(): 3.2e-89%2C (81.85%25 identity in 314 aa overlap). Also highly similar to many e.g. O69967|MIAA_STRCO|SC4H2.12 from Streptomyces coelicolor (312 aa)%2C FASTA scores: opt: 1006%2CE(): 1.2e-50%2C (55.5%25 identity in 301 aa overlap)%3B O31795|MIAA_BACSU from Bacillus subtilis (314 aa)%2C FASTA scores: opt: 671%2C E(): 1.9e-31%2C (38.55%25 identity in 293 aa overlap)%3BP16384|MIAA_ECOLI|TRPX|B4171 from Escherichia coli strain K12 and Shigella flexneri (316 aa)%2C FASTA scores: opt: 565%2C E(): 2.3e-25%2C (35.2%25 identity in 307 aa overlap)%3Betc. Contains PS00017 ATP/GTP-binding site motif A (P -loop). Belongs to the IPP transferase family.;gbkey=CDS;gene=miaA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2727c;product=Probable tRNA delta(2)-isopentenylpyrophosphate transferase MiaA (IPP transferase) (isopentenyl-diphosphate:tRNA isopentenyltransferase) (iptase) (IPPT);protein_id=CCP45525.1;transl_table=11
AL123456.3	EMBL	gene	3040766	3041461	.	-	.	ID=gene-Rv2728c;Name=Rv2728c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2728c
AL123456.3	EMBL	CDS	3040766	3041461	.	-	0	ID=cds-CCP45526.1;Parent=gene-Rv2728c;Dbxref=EnsemblGenomes-Gn:Rv2728c,EnsemblGenomes-Tr:CCP45526,UniProtKB/TrEMBL:I6X579,NCBI_GP:CCP45526.1;Name=CCP45526.1;Note=Rv2728c%2C (MTCY154.08c)%2C len: 231 aa. Conserved ala-rich protein%2C equivalent to Q49835|ML0994|B2235_C1_162 hypothetical protein from Mycobacterium leprae (232 aa)%2CFASTA scores: opt: 1037%2C E(): 1.2e-54%2C (68.55%25 identity in 232 aa overlap). Also similar to O69964|SC4H2.09 from Streptomyces coelicolor (237 aa)%2C FASTA scores: opt: 300%2CE(): 7.7e-11%2C (32.8%25 identity in 241 aa overlap)%3B and some similarity with other proteins e.g. Q14234|ELN elastin from Homo sapiens (Human) (757 aa)%2C FASTA scores: opt: 161%2C E(): 0.03%2C (30.6%25 identity in 242 aa overlap)%3B P55488|Y4IE hypothetical 15.4 KDA protein from Rhizobium sp. strain NGR234 (135 aa)%2C FASTA scores: opt: 147%2C E(): 0.061%2C(34.95%25 identity in 123 aa overlap). Shows also some similarity with P71657|Rv1387|MTCY21B4.04 hypothetical protein from Mycobacterium tuberculosis (539 aa)%2C FASTA scores: opt: 159%2C E(): 0.035%2C (34.8%25 identity in 135 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2728c;product=Conserved alanine rich protein;protein_id=CCP45526.1;transl_table=11
AL123456.3	EMBL	gene	3041570	3042475	.	-	.	ID=gene-Rv2729c;Name=Rv2729c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2729c
AL123456.3	EMBL	CDS	3041570	3042475	.	-	0	ID=cds-CCP45527.1;Parent=gene-Rv2729c;Dbxref=EnsemblGenomes-Gn:Rv2729c,EnsemblGenomes-Tr:CCP45527,UniProtKB/TrEMBL:O33234,NCBI_GP:CCP45527.1;Name=CCP45527.1;Note=Rv2729c%2C (MTCY154.09c)%2C len: 301 aa. Probable conserved integral membrane ala-%2C val-%2C leu-rich protein%2Csimilar to P42459|YLEU_CORGL hypothetical 29.6 KDA protein from Corynebacterium glutamicum (Brevibacterium flavum)(270 aa)%2C FASTA scores: opt: 365%2C E(): 4.7e-15%2C (30.75%25 identity in 221 aa overlap)%3B and to other integral membrane proteins (principally from Streptomyces sp.) e.g. Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa)%2C FASTA scores: opt: 365%2C E(): 5.2e-15%2C (32.0%25 identity in 278 aa overlap)%3B Q9S267|SCI30A.06 from Streptomyces coelicolor (297 aa)%2CFASTA scores: opt: 356%2C E(): 1.8e-14%2C (31.5%25 identity in 289 aa overlap)%3B AAK81278|CAC3346 from Clostridium acetobutylicum (472 aa)%2C FASTA scores: opt: 154%2C E(): 0.038%2C (24.1%25 identity in 224 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2729c;product=Probable conserved integral membrane alanine valine and leucine rich protein;protein_id=CCP45527.1;transl_table=11
AL123456.3	EMBL	gene	3042542	3043018	.	+	.	ID=gene-Rv2730;Name=Rv2730;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2730
AL123456.3	EMBL	CDS	3042542	3043018	.	+	0	ID=cds-CCP45528.1;Parent=gene-Rv2730;Dbxref=EnsemblGenomes-Gn:Rv2730,EnsemblGenomes-Tr:CCP45528,UniProtKB/TrEMBL:I6Y1K4,NCBI_GP:CCP45528.1;Name=CCP45528.1;Note=Rv2730%2C (MTCY174.10)%2C len: 158 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2730;product=Hypothetical protein;protein_id=CCP45528.1;transl_table=11
AL123456.3	EMBL	gene	3043026	3044378	.	+	.	ID=gene-Rv2731;Name=Rv2731;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2731
AL123456.3	EMBL	CDS	3043026	3044378	.	+	0	ID=cds-CCP45529.1;Parent=gene-Rv2731;Dbxref=EnsemblGenomes-Gn:Rv2731,EnsemblGenomes-Tr:CCP45529,InterPro:IPR007139,UniProtKB/TrEMBL:I6XF60,NCBI_GP:CCP45529.1;Name=CCP45529.1;Note=Rv2731%2C (MTCY174.11)%2C len: 450 aa. Conserved ala-%2Carg-rich protein%2C highly similar in part to Q49849|B2235_F2_77 hypothetical protein from Mycobacterium leprae (266 aa)%2C FASTA scores: opt: 368%2C E(): 1e-10%2C (73.5%25 identity in 83 aa overlap)%3B and Q9KXN9|SC9C5.35 hypothetical 6.5 KDA protein (fragment) from Streptomyces coelicolor (58 aa)%2C FASTA scores: opt: 214%2C E(): 0.00065%2C(51.7%25 identity in 58 aa overlap). Also similar to Q9L296|SCL2.01 hypothetical 37.4 KDA protein (fragment) from Streptomyces coelicolor (328 aa)%2C FASTA scores: opt: 843%2C E(): 3.7e-33%2C (45.95%25 identity in 296 aa overlap) (but N-terminus shorter)%3B and shows some similarity with other proteins e.g. Q26938 kinetoplast-associated protein (KAP) from Trypanosoma cruzi (1052 aa)%2C FASTA scores: opt: 223%2CE(): 0.0022%2C (30.3%25 identity in 297 aa overlap). Start site chosen by RBS and to avoid overlap%2C although there are several other possible start sites further upstream.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2731;product=Conserved alanine and arginine rich protein;protein_id=CCP45529.1;transl_table=11
AL123456.3	EMBL	gene	3044375	3044989	.	-	.	ID=gene-Rv2732c;Name=Rv2732c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2732c
AL123456.3	EMBL	CDS	3044375	3044989	.	-	0	ID=cds-CCP45530.1;Parent=gene-Rv2732c;Dbxref=EnsemblGenomes-Gn:Rv2732c,EnsemblGenomes-Tr:CCP45530,GOA:O33237,UniProtKB/TrEMBL:O33237,NCBI_GP:CCP45530.1;Name=CCP45530.1;Note=Rv2732c%2C (MTCY174.12c)%2C len: 204 aa. Probable conserved transmembrane protein%2C similar to Q49834 hypothetical protein B2235_C1_155 from Mycobacterium leprae (209 aa)%2C FASTA scores: opt: 932%2C E(): 0%2C (70.6%25 identity in 201 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00343;locus_tag=Rv2732c;product=Probable conserved transmembrane protein;protein_id=CCP45530.1;transl_table=11
AL123456.3	EMBL	gene	3044986	3046524	.	-	.	ID=gene-Rv2733c;Name=Rv2733c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2733c
AL123456.3	EMBL	CDS	3044986	3046524	.	-	0	ID=cds-CCP45531.1;Parent=gene-Rv2733c;Dbxref=EnsemblGenomes-Gn:Rv2733c,EnsemblGenomes-Tr:CCP45531,GOA:P9WK05,InterPro:IPR002792,InterPro:IPR005839,InterPro:IPR006463,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR013848,InterPro:IPR020612,InterPro:IPR023404,InterPro:IPR023970,NCBI_GP:CCP45531.1;Name=CCP45531.1;Note=Rv2733c%2C (MTCY154.13c)%2C len: 512 aa. Conserved hypothetical ala-%2C arg-rich protein. Similar to other hypothetical proteins from a range of organisms e.g. Y195_MYCLE|Q49842 hypothetical 56.0 kDa protein b2235_c2_195 from Mycobacterium leprae (516 aa)%2C FASTA scores: opt: 2689%2C E(): 0%2C (80.4%25 identity in 509 aa overlap).;gbkey=CDS;locus_tag=Rv2733c;product=Conserved hypothetical alanine%2C arginine-rich protein;protein_id=CCP45531.1;transl_table=11
AL123456.3	EMBL	gene	3046821	3047675	.	+	.	ID=gene-Rv2734;Name=Rv2734;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2734
AL123456.3	EMBL	CDS	3046821	3047675	.	+	0	ID=cds-CCP45532.1;Parent=gene-Rv2734;Dbxref=EnsemblGenomes-Gn:Rv2734,EnsemblGenomes-Tr:CCP45532,InterPro:IPR011101,UniProtKB/TrEMBL:I6YA42,NCBI_GP:CCP45532.1;Name=CCP45532.1;Note=Rv2734%2C (MTCY154.14)%2C len: 284 aa. Conserved hypothetical protein%2C highly similar to various proteins e.g. Q984J2|MLR7981 ABC transporter ATP-binding protein from Rhizobium loti (Mesorhizobium loti) (286 aa)%2C FASTA scores: opt: 877%2C E(): 9e-50%2C (52.45%25 identity in 246 aa overlap) (N-terminus longer)%3B Q98DH1|MLL4707 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (249 aa)%2CFASTA scores: opt: 829%2C E(): 1.1e-46%2C (50.4%25 identity in 244 aa overlap)%3B AAK65865|SMA2239 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (259 aa)%2C FASTA scores: opt: 796%2C E(): 1.5e-44%2C (50.0%25 identity in 252 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2734;product=Conserved hypothetical protein;protein_id=CCP45532.1;transl_table=11
AL123456.3	EMBL	gene	3047560	3048552	.	-	.	ID=gene-Rv2735c;Name=Rv2735c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2735c
AL123456.3	EMBL	CDS	3047560	3048552	.	-	0	ID=cds-CCP45533.1;Parent=gene-Rv2735c;Dbxref=EnsemblGenomes-Gn:Rv2735c,EnsemblGenomes-Tr:CCP45533,UniProtKB/TrEMBL:I6Y1K7,NCBI_GP:CCP45533.1;Name=CCP45533.1;Note=Rv2735c%2C (MTCY154.15c)%2C len: 330 aa. Conserved hypothetical protein%2C showing some similarity with Q98DH2|MLR4706 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (302 aa)%2C FASTA scores: opt: 140%2C E(): 0.062%2C (27.0%25 identity in 200 aa overlap)%3B and Q9PHA1|XF0043 hypothetical protein from Xylella fastidiosa (293 aa)%2C FASTA scores: opt: 120%2C E(): 1.2%2C (30.75%25 identity in 117 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2735c;product=Conserved hypothetical protein;protein_id=CCP45533.1;transl_table=11
AL123456.3	EMBL	gene	3048562	3049086	.	-	.	ID=gene-Rv2736c;Name=recX;gbkey=Gene;gene=recX;gene_biotype=protein_coding;locus_tag=Rv2736c
AL123456.3	EMBL	CDS	3048562	3049086	.	-	0	ID=cds-CCP45534.1;Parent=gene-Rv2736c;Dbxref=EnsemblGenomes-Gn:Rv2736c,EnsemblGenomes-Tr:CCP45534,GOA:P9WHI1,InterPro:IPR003783,InterPro:IPR011991,NCBI_GP:CCP45534.1;Name=CCP45534.1;Note=Rv2736c%2C (MTV002.01c)%2C len: 174 aa. Probable recX%2Cregulatory protein (see citation below)%2C equivalent to P37859|RECX_MYCLE|ML0988|U2235B regulatory protein RECX from Mycobacterium leprae (171 aa)%2C FASTA scores: opt: 848%2CE(): 2e-46%2C (77.0%25 identity in 174 aa overlap)%3B and CAA67596|RECX|P94965|RECX_MYCSM regulatory protein RECX from Mycobacterium smegmatis (188 aa)%2C FASTA scores: opt: 679%2C E(): 8.8e-36%2C (66.45%25 identity in 164 aa overlap). Also similar (or highly similar to) others e.g. O50488|RECX_STRCO|SC4H8.09 from Streptomyces coelicolor (188 aa)%2C FASTA scores: opt: 371%2C E(): 1.9e-16%2C (42.7%25 identity in 164 aa overlap)%3B Q9LCZ3|RECX from Xanthomonas campestris pv. citri (162 aa)%2C FASTA scores: opt: 189%2C E(): 4.4e-05%2C (32.45%25 identity in 151 aa overlap)%3B P37860|RECX_PSEAE|PA3616 from Pseudomonas aeruginosa (153 aa)%2C FASTA scores: opt: 159%2C E(): 0.0032%2C (30.65%25 identity in 137 aa overlap)%3B etc. Belongs to the RecX family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recX;locus_tag=Rv2736c;product=Regulatory protein RecX;protein_id=CCP45534.1;transl_table=11
AL123456.3	EMBL	gene	3049052	3051424	.	-	.	ID=gene-Rv2737c;Name=recA;gbkey=Gene;gene=recA;gene_biotype=protein_coding;locus_tag=Rv2737c
AL123456.3	EMBL	CDS	3049052	3051424	.	-	0	ID=cds-CCP45535.1;Parent=gene-Rv2737c;Dbxref=EnsemblGenomes-Gn:Rv2737c,EnsemblGenomes-Tr:CCP45535,GOA:P9WHJ3,InterPro:IPR003586,InterPro:IPR003587,InterPro:IPR003593,InterPro:IPR004042,InterPro:IPR006141,InterPro:IPR006142,InterPro:IPR013765,InterPro:IPR020584,InterPro:IPR020587,InterPro:IPR020588,InterPro:IPR023400,InterPro:IPR027417,InterPro:IPR027434,InterPro:IPR028992,PDB:1G18,PDB:1G19,PDB:1MO3,PDB:1MO4,PDB:1MO5,PDB:1MO6,PDB:2IMZ,PDB:2IN0,PDB:2IN8,PDB:2IN9,PDB:2L8L,PDB:3IFJ,PDB:3IGD,NCBI_GP:CCP45535.1;Name=CCP45535.1;Note=Rv2737c%2C (MTV002.02c)%2C len: 790 aa. RecA%2Crecombinase a (see citations below)%2C equivalent to Q59560|RECA_MYCSM RECA protein from Mycobacterium smegmatis (349 aa)%2C FASTA scores: opt: 1495%2C E(): 1.9e-79%2C (93.15%25 identity in 249 aa overlap)%3B and P35901|RECA_MYCLE|ML0987 RECA protein from Mycobacterium leprae (711 aa)%2C FASTA scores: opt: 1217%2C E(): 4.5e-63%2C (46.7%25 identity in 814 aa overlap). Also highly similar to many e.g. Q9REV6|RECA_AMYMD from Amycolatopsis mediterranei (Nocardia mediterranei) (348 aa)%2C FASTA scores: opt: 1450%2C E(): 7.6e-77%2C (89.25%25 identity in 251 aa overlap)%3B P42442|RECA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (376 aa)%2C FASTA scores: opt: 1355%2CE(): 2.6e-71%2C (76.55%25 identity in 273 aa overlap)%3B P41054|RECA_STRAM from Streptomyces ambofaciens (372 aa)%2CFASTA scores: opt: 1347%2C E(): 7.6e-71%2C (82.1%25 identity in 246 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00321 recA signature%2C and PS00881 Protein splicing signature. Belongs to the RecA family. This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. Belongs to the homing endonuclease family in the intein section.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recA;inference=protein motif:PROSITE:PS00881;locus_tag=Rv2737c;product=RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].;protein_id=CCP45535.1;transl_table=11
AL123456.3	EMBL	gene	3051619	3051792	.	+	.	ID=gene-Rv2737A;Name=Rv2737A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2737A
AL123456.3	EMBL	CDS	3051619	3051792	.	+	0	ID=cds-CCP45536.1;Parent=gene-Rv2737A;Dbxref=EnsemblGenomes-Gn:Rv2737A,EnsemblGenomes-Tr:CCP45536,GOA:Q79FB4,InterPro:IPR024726,UniProtKB/TrEMBL:Q79FB4,NCBI_GP:CCP45536.1;Name=CCP45536.1;Note=Rv2737A%2C len: 57 aa. Conserved hypothetical cys-rich protein (possibly gene fragment)%2C similar to central part of AJ243803_1|glgA from Streptomyces coelicolor glgA (181 aa)%2C FASTA scores: opt: 210%2C E(): 6.1e-09%2C (59.25%25 identity in 54 aa overlap).;gbkey=CDS;locus_tag=Rv2737A;product=Conserved hypothetical cysteine rich protein (fragment);protein_id=CCP45536.1;transl_table=11
AL123456.3	EMBL	gene	3051806	3052012	.	-	.	ID=gene-Rv2738c;Name=Rv2738c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2738c
AL123456.3	EMBL	CDS	3051806	3052012	.	-	0	ID=cds-CCP45537.1;Parent=gene-Rv2738c;Dbxref=EnsemblGenomes-Gn:Rv2738c,EnsemblGenomes-Tr:CCP45537,InterPro:IPR021408,UniProtKB/TrEMBL:I6YA47,NCBI_GP:CCP45537.1;Name=CCP45537.1;Note=Rv2738c%2C (MTV002.03c)%2C len: 68 aa. Conserved hypothetical protein%2C equivalent to Q9CCC1|ML0986 hypothetical protein from Mycobacterium leprae (67 aa)%2CFASTA scores: opt: 397%2C E(): 3.7e-22%2C (83.6%25 identity in 67 aa overlap). Also highly similar to O50484|SC4H8.05 hypothetical 7.5 KDA protein from Streptomyces coelicolor (64 aa)%2C FASTA scores: opt: 185%2C E(): 5.9e-07%2C (39.7%25 identity in 63 aa overlap). Second part of the protein is highly similar to C-terminus of upstream ORF O33285|Rv2742c|MTV002.07c conserved hypothetical protein from Mycobacterium tuberculosis (277 aa)%2C FASTA scores: opt: 200%2C E(): 1.7e-07%2C (78.4%25 identity in 37 aa overlap).;gbkey=CDS;locus_tag=Rv2738c;product=Conserved hypothetical protein;protein_id=CCP45537.1;transl_table=11
AL123456.3	EMBL	gene	3052023	3053189	.	-	.	ID=gene-Rv2739c;Name=Rv2739c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2739c
AL123456.3	EMBL	CDS	3052023	3053189	.	-	0	ID=cds-CCP45538.1;Parent=gene-Rv2739c;Dbxref=EnsemblGenomes-Gn:Rv2739c,EnsemblGenomes-Tr:CCP45538,GOA:O33282,InterPro:IPR002213,InterPro:IPR007235,UniProtKB/TrEMBL:O33282,NCBI_GP:CCP45538.1;Name=CCP45538.1;Note=Rv2739c%2C (MTV002.04c)%2C len: 388 aa. Possible ala-rich transferase%2C equivalent to Q49841|ML0985|MLCB33.02c|U2235C possible glycosyltransferase from Mycobacterium leprae (392 aa)%2CFASTA scores: opt: 2112%2C E(): 5.1e-114%2C (80.95%25 identity in 388 aa overlap). Shows some similarity with other transferases e.g. Q9S1V2|SCJ4.21 putative glycosyl transferase from Streptomyces coelicolor (407 aa)%2C FASTA scores: opt: 290%2C E(): 2e-09%2C (27.75%25 identity in 382 aa overlap)%3B Q9RYI3|DRA0329 putative glycosyltransferase from Deinococcus radiodurans (418 aa)%2C FASTA scores: opt: 267%2CE(): 4.3e-08%2C (29.05%25 identity in 396 aa overlap)%3B P96560|GTFC glycosyltransferase from Amycolatopsis orientalis (409 aa)%2C FASTA scores: opt: 253%2C E(): 2.7e-07%2C(27.75%25 identity in 418 aa overlap)%3B etc. Equivalent to AAK47130 from Mycobacterium tuberculosis strain CDC1551 (420 aa) but shorter 32 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2739c;product=Possible alanine rich transferase;protein_id=CCP45538.1;transl_table=11
AL123456.3	EMBL	gene	3053233	3053682	.	+	.	ID=gene-Rv2740;Name=ephG;gbkey=Gene;gene=ephG;gene_biotype=protein_coding;locus_tag=Rv2740
AL123456.3	EMBL	CDS	3053233	3053682	.	+	0	ID=cds-CCP45539.1;Parent=gene-Rv2740;Dbxref=EnsemblGenomes-Gn:Rv2740,EnsemblGenomes-Tr:CCP45539,GOA:O33283,InterPro:IPR013100,PDB:2BNG,NCBI_GP:CCP45539.1;Name=CCP45539.1;Note=Rv2740%2C (MTV002.05)%2C len: 149 aa. EphG%2C Epoxide hydrolase%2C proven biochemically (see Unge et al. 2005)%2Csimilar to limonene-1%2C2-epoxide hydrolase capable of hydrolyzing long or bulky lipophilic epoxides. Equivalent%2Cbut shorter 17 aa%2C to Q9CCC2|ML0984 (alias Q49850 but longer) hypothetical protein from Mycobacterium leprae (164 aa)%2C FASTA scores: opt: 481%2C E(): 9.7e-26%2C (52.0%25 identity in 150 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ephG;locus_tag=Rv2740;product=Epoxide hydrolase;protein_id=CCP45539.1;transl_table=11
AL123456.3	EMBL	gene	3053914	3055491	.	+	.	ID=gene-Rv2741;Name=PE_PGRS47;gbkey=Gene;gene=PE_PGRS47;gene_biotype=protein_coding;locus_tag=Rv2741
AL123456.3	EMBL	CDS	3053914	3055491	.	+	0	ID=cds-CCP45540.1;Parent=gene-Rv2741;Dbxref=EnsemblGenomes-Gn:Rv2741,EnsemblGenomes-Tr:CCP45540,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FB3,NCBI_GP:CCP45540.1;Name=CCP45540.1;Note=Rv2741%2C (MTV002.06)%2C len: 525 aa. PE_PGRS47%2C Member of the M. tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to others e.g. Q10637|YD25_MYCTU|Rv1325c|MT1367|MTCY130.10c hypothetical PE-PGRS family protein (603 aa)%2C FASTA scores: opt: 1936%2C E(): 1.1e-71%2C (56.95%25 identity in 611 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS47;locus_tag=Rv2741;product=PE-PGRS family protein PE_PGRS47;protein_id=CCP45540.1;transl_table=11
AL123456.3	EMBL	gene	3055515	3056348	.	-	.	ID=gene-Rv2742c;Name=Rv2742c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2742c
AL123456.3	EMBL	CDS	3055515	3056348	.	-	0	ID=cds-CCP45541.1;Parent=gene-Rv2742c;Dbxref=EnsemblGenomes-Gn:Rv2742c,EnsemblGenomes-Tr:CCP45541,GOA:O33285,InterPro:IPR021408,UniProtKB/TrEMBL:O33285,NCBI_GP:CCP45541.1;Name=CCP45541.1;Note=Rv2742c%2C (MTV002.07c)%2C len: 277 aa (questionable ORF). Conserved hypothetical arg-rich protein. Extreme N-terminus is highly similar to the N-teminus of Q9CCC1ML0986 hypothetical protein from Mycobacterium leprae (67 aa)%2C FASTA scores: opt: 183%2C E(): 0.00052%2C (71.05%25 identity in 38 aa overlap)%3B and to the downstream ORF O33281|Rv2738c|MTV002.03c conserved hypothetical protein from Mycobacterium tuberculosis (68 aa)%2C FASTA scores: opt: 200%2C E(): 5.5e-05%2C (78.4%25 identity in 37 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2742c;product=Conserved hypothetical arginine rich protein;protein_id=CCP45541.1;transl_table=11
AL123456.3	EMBL	gene	3056420	3057232	.	-	.	ID=gene-Rv2743c;Name=Rv2743c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2743c
AL123456.3	EMBL	CDS	3056420	3057232	.	-	0	ID=cds-CCP45542.1;Parent=gene-Rv2743c;Dbxref=EnsemblGenomes-Gn:Rv2743c,EnsemblGenomes-Tr:CCP45542,GOA:I6YA50,UniProtKB/TrEMBL:I6YA50,NCBI_GP:CCP45542.1;Name=CCP45542.1;Note=Rv2743c%2C (MTV002.08c)%2C len: 270 aa. Possible conserved transmembrane ala-rich protein%2C equivalent to Q49833|MLCB33.04c|B2235_C1_148 unknown protein from Mycobacterium leprae (123 aa)%2C FASTA scores: opt: 639%2C E(): 3.3e-31%2C (74.8%25 identity in 123 aa overlap).;gbkey=CDS;locus_tag=Rv2743c;product=Possible conserved transmembrane alanine rich protein;protein_id=CCP45542.1;transl_table=11
AL123456.3	EMBL	gene	3057251	3058063	.	-	.	ID=gene-Rv2744c;Name=35kd_ag;gbkey=Gene;gene=35kd_ag;gene_biotype=protein_coding;locus_tag=Rv2744c
AL123456.3	EMBL	CDS	3057251	3058063	.	-	0	ID=cds-CCP45543.1;Parent=gene-Rv2744c;Dbxref=EnsemblGenomes-Gn:Rv2744c,EnsemblGenomes-Tr:CCP45543,GOA:P9WHP5,InterPro:IPR007157,NCBI_GP:CCP45543.1;Name=CCP45543.1;Note=Rv2744c%2C (MTV002.09c)%2C len: 270 aa. 35kd_ag%2Cconserved ala-rich protein 35-kd antigen (see O'Connor et al.%2C 1990). N-terminal part is equivalent to Q49840|MLCB33.06c|B2235_C2_187 hypothetical protein from Mycobacterium leprae (167 aa)%2C FASTA scores: opt: 789%2C E(): 3.4e-35%2C (85.05%25 identity in 147 aa overlap)%3B and C-terminal part equivalent to Q49845|MLCB33.05c|B2235_C3_214 hypothetical protein from Mycobacterium leprae (114 aa)%2C FASTA scores: opt: 465%2C E(): 3.6e-18%2C (65.8%25 identity in 114 aa overlap)%3B note that these two proteins from Mycobacterium leprae are adjacent. Shows some similarity with Q55707||Y617_SYNY3|SLL0617 hypothetical 28.9 KDA protein from Synechocystis sp. strain PCC 6803 (267 aa)%2C FASTA scores: opt: 155%2C E(): 0.19%2C(23.4%25 identity in 252 aa overlap)%3B and C-terminus of Q9L4N1|EMM M protein from Streptococcus equisimilis (592 aa)%2C FASTA scores: opt: 165%2C E(): 0.11%2C (23.45%25 identity in 260 aa overlap). C-terminus also similar to AAK45945|MT1676 conserved hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (85 aa)%2C FASTA scores: opt: 159%2C E(): 0.047%2C (50.9%25 identity in 55 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=35kd_ag;locus_tag=Rv2744c;product=Conserved 35 kDa alanine rich protein;protein_id=CCP45543.1;transl_table=11
AL123456.3	EMBL	gene	3058193	3058531	.	-	.	ID=gene-Rv2745c;Name=clgR;gbkey=Gene;gene=clgR;gene_biotype=protein_coding;locus_tag=Rv2745c
AL123456.3	EMBL	CDS	3058193	3058531	.	-	0	ID=cds-CCP45544.1;Parent=gene-Rv2745c;Dbxref=EnsemblGenomes-Gn:Rv2745c,EnsemblGenomes-Tr:CCP45544,GOA:P9WMH7,InterPro:IPR001387,InterPro:IPR010982,NCBI_GP:CCP45544.1;Name=CCP45544.1;Note=Rv2745c%2C (MTV002.10c)%2C len: 112 aa. ClgR%2Ctranscriptional regulatory protein%2C controls protease systems and chaperones.;gbkey=CDS;gene=clgR;locus_tag=Rv2745c;product=Transcriptional regulatory protein ClgR;protein_id=CCP45544.1;transl_table=11
AL123456.3	EMBL	gene	3058602	3059231	.	-	.	ID=gene-Rv2746c;Name=pgsA3;gbkey=Gene;gene=pgsA3;gene_biotype=protein_coding;locus_tag=Rv2746c
AL123456.3	EMBL	CDS	3058602	3059231	.	-	0	ID=cds-CCP45545.1;Parent=gene-Rv2746c;Dbxref=EnsemblGenomes-Gn:Rv2746c,EnsemblGenomes-Tr:CCP45545,GOA:P9WPG3,InterPro:IPR000462,InterPro:IPR004570,NCBI_GP:CCP45545.1;Name=CCP45545.1;Note=Rv2746c%2C (MTV002.11c)%2C len: 209 aa. Probable pgsA3%2CPGP synthase (see citation below)%2C transmembrane protein%2Cequivalent%2C but longer 19 aa%2C to Q49839|O08087|PGSA|ML0979 PGSA from Mycobacterium leprae (193 aa)%2C FASTA scores: opt: 925%2C E(): 3.7e-53%2C (77.15%25 identity in 188 aa overlap). Also highly similar to O86813|PGSA phosphatidylglycerophosphate synthase from Streptomyces coelicolor (263 aa)%2C FASTA scores: opt: 692%2C E(): 6.6e-38%2C(57.85%25 identity in 185 aa overlap) (has its N-terminus longer)%3B and similar to others (generally with N-terminus shorter) e.g. Q99XI0|PGSA|SPY2196 phosphatidylglycerophosphate synthase from Streptococcus pyogenes (180 aa)%2C FASTA scores: opt: 368%2C E(): 5.4e-17%2C(39.9%25 identity in 168 aa overlap)%3B Q9ZE96|PGSA_RICPR|PGSA|RP049 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Rickettsia prowazekii (181 aa)%2C FASTA scores: opt: 343%2C E(): 2.3e-15%2C (40.1%25 identity in 172 aa overlap)%3B P06978|PGSA_ECOLI|PGSA|B1912|Z3000|ECS2650 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Escherichia coli strains K12 and O157:H7 (181 aa)%2C FASTA scores: opt: 322%2C E(): 5.3e-14%2C(34.45%25 identity in 180 aa overlap)%3B etc. Also some similarity to PGSA2|Rv1822|MTCY1A11.21c probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase from Mycobacterium tuberculosis (209 aa)%2C FASTA score: (27.1%25 identity in 166 aa overlap). Contains PS00379 CDP-alcohol phosphatidyltransferases signature. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pgsA3;inference=protein motif:PROSITE:PS00379;locus_tag=Rv2746c;product=Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase) (phosphatidylglycerophosphate synthase);protein_id=CCP45545.1;transl_table=11
AL123456.3	EMBL	gene	3059262	3059786	.	+	.	ID=gene-Rv2747;Name=argA;gbkey=Gene;gene=argA;gene_biotype=protein_coding;locus_tag=Rv2747
AL123456.3	EMBL	CDS	3059262	3059786	.	+	0	ID=cds-CCP45546.1;Parent=gene-Rv2747;Dbxref=EnsemblGenomes-Gn:Rv2747,EnsemblGenomes-Tr:CCP45546,GOA:O33289,InterPro:IPR000182,InterPro:IPR016181,NCBI_GP:CCP45546.1;Name=CCP45546.1;Note=Rv2747%2C (MTV002.12)%2C len: 174 aa. Probable argA%2Calpha-N-acetylglutamate synthase (See Errey et al.%2C 2005). Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Equivalent to O05559|ML0978|MLCB33.08 putative acetyltransferase from Mycobacterium leprae (180 aa)%2C FASTA scores: opt: 997%2C E(): 1.2e-57%2C (86.8%25 identity in 174 aa overlap). Also similar to various transferases e.g. Q9X8N2|SCE94.27c putative acetyltransferase from Streptomyces coelicolor (169 aa)%2CFASTA scores: opt: 656%2C E(): 1.3e-35%2C (60.35%25 identity in 164 aa overlap)%3B C-terminus of Q9K3D6|ARGH(A) argininosuccinase and N-acetylglutamate synthase from Moritella sp. 2693 (629 aa)%2C FASTA scores: opt: 243%2C E(): 2e-08%2C (31.95%25 identity in 144 aa overlap)%3B C-terminus of Q9JW21|ARGA or NMA0580 putative acetylglutamate synthase from Neisseria meningitidis serogroup a (436 aa)%2C FASTA scores: opt: 201%2C E(): 7.8e-06%2C (32.75%25 identity in 119 aa overlap)%3B etc. Also similar to hypothetical proteins e.g. O67372|AQ_1359 hypothetical 21.1 KDA protein from Aquifex aeolicus (181 aa)%2C FASTA scores: opt: 348%2C E(): 1.2e-15%2C(42.35%25 identity in 137 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=argA;locus_tag=Rv2747;product=Probable L-glutamate alpha-N-acetyltranferase ArgA (alpha-N-acetylglutamate synthase);protein_id=CCP45546.1;transl_table=11
AL123456.3	EMBL	gene	3059855	3062506	.	-	.	ID=gene-Rv2748c;Name=ftsK;gbkey=Gene;gene=ftsK;gene_biotype=protein_coding;locus_tag=Rv2748c
AL123456.3	EMBL	CDS	3059855	3062506	.	-	0	ID=cds-CCP45547.1;Parent=gene-Rv2748c;Dbxref=EnsemblGenomes-Gn:Rv2748c,EnsemblGenomes-Tr:CCP45547,GOA:P9WNA3,InterPro:IPR002543,InterPro:IPR003593,InterPro:IPR018541,InterPro:IPR025199,InterPro:IPR027417,NCBI_GP:CCP45547.1;Name=CCP45547.1;Note=Rv2748c%2C (MTV002.13c)%2C len: 883 aa. Possible ftsK%2Ccell division transmembrane protein%2C equivalent to O05560|ML0977|FTSK|MLCB33.09c cell division protein from Mycobacterium leprae (886 aa)%2C FASTA scores: opt: 3147%2CE(): 7.9e-175%2C (78.1%25 identity in 885 aa overlap). Also similar to other members of the spoIIIE/ftsK family e.g. O86810|SC7C7.05 FTSK homolog from Streptomyces coelicolor (929 aa)%2C FASTA scores: opt: 2256%2C E(): 3.8e-123%2C (49.05%25 identity in 924 aa overlap)%3B Q9CF25|FTSK cell division protein FTSK from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (763 aa)%2C FASTA scores: opt: 1438%2CE(): 9.1e-76%2C (37.7%25 identity in 751 aa overlap)%3B AAK75005|Q97RE4|SP0878 SPOE family protein from Streptococcus pneumoniae (767 aa)%2C FASTA scores: opt: 1405%2CE(): 7.5e-74%2C (48.0%25 identity in 477 aa overlap)%3B P46889|FTSK_ECOLI|B0890 from Escherichia coli strain K12 (1329 aa)%2C FASTA scores: opt: 759%2C E(): 0%2C (44.5%25 identity in 537 aa overlap) (similarity in C-terminal half)%3B etc. Equivalent to AAK47139 from Mycobacterium tuberculosis strain CDC1551 (968 aa) but shorter 85 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the FTSK/SPOIIIE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ftsK;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2748c;product=Possible cell division transmembrane protein FtsK;protein_id=CCP45547.1;transl_table=11
AL123456.3	EMBL	gene	3062505	3062819	.	+	.	ID=gene-Rv2749;Name=Rv2749;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2749
AL123456.3	EMBL	CDS	3062505	3062819	.	+	0	ID=cds-CCP45548.1;Parent=gene-Rv2749;Dbxref=EnsemblGenomes-Gn:Rv2749,EnsemblGenomes-Tr:CCP45548,InterPro:IPR007138,InterPro:IPR011008,UniProtKB/TrEMBL:O33291,NCBI_GP:CCP45548.1;Name=CCP45548.1;Note=Rv2749%2C (MTV002.14)%2C len: 104 aa. Conserved protein%2Cshowing some similarity with Q9I1R9|PA2198 hypothetical protein from Pseudomonas aeruginosa (114 aa)%2C FASTA scores: opt: 157%2C E(): 0.00081%2C (35.0%25 identity in 100 aa overlap)%3B and O86332|Rv0793|MTV042.03 hypothetical 11.2 KDA protein from Mycobacterium tuberculosis (101 aa)%2C FASTA scores: opt: 143%2C E(): 0.0062%2C (26.9%25 identity in 93 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2749;product=Conserved protein;protein_id=CCP45548.1;transl_table=11
AL123456.3	EMBL	gene	3062816	3063634	.	+	.	ID=gene-Rv2750;Name=Rv2750;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2750
AL123456.3	EMBL	CDS	3062816	3063634	.	+	0	ID=cds-CCP45549.1;Parent=gene-Rv2750;Dbxref=EnsemblGenomes-Gn:Rv2750,EnsemblGenomes-Tr:CCP45549,GOA:P9WGS5,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,InterPro:IPR023985,NCBI_GP:CCP45549.1;Name=CCP45549.1;Note=Rv2750%2C (MTV002.15)%2C len: 272 aa. Probable dehydrogenase%2C highly similar to other dehydrogenases/reductases e.g. Q9L5X5|cox cholesterol oxidase from Nocardioides simplex (Arthrobacter simplex) (270 aa)%2C FASTA scores: opt: 836%2C E(): 1.8e-43%2C (55.7%25 identity in 264 aa overlap)%3B Q9RA05|LIMC carveol dehydrogenase from Rhodococcus erythropolis (277 aa)%2C FASTA scores: opt: 792%2C E(): 8.6e-41%2C (48.55%25 identity in 274 aa overlap)%3B Q9F5J1|SIM-NJ1|SIMD2 putative 3-keto-acyl-reductase from Streptomyces antibioticus (273 aa)%2C FASTA scores: opt: 435%2C E(): 3.7e-19%2C (35.75%25 identity in 263 aa overlap)%3B etc. Also highly similar to AAK44941MT0715 oxidoreductase (short-chain dehydrogenase/reductase family) from Mycobacterium tuberculosis strain CDC1551 (275 aa)%2C FASTA scores: opt: 702%2C E(): 2.4e-35%2C (44.45%25 identity in 270 aa overlap)%3B and similar to many other Mycobacterium tuberculosis dehydrogenases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2750;product=Probable dehydrogenase;protein_id=CCP45549.1;transl_table=11
AL123456.3	EMBL	gene	3063638	3064528	.	+	.	ID=gene-Rv2751;Name=Rv2751;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2751
AL123456.3	EMBL	CDS	3063638	3064528	.	+	0	ID=cds-CCP45550.1;Parent=gene-Rv2751;Dbxref=EnsemblGenomes-Gn:Rv2751,EnsemblGenomes-Tr:CCP45550,GOA:I6YEA3,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,UniProtKB/TrEMBL:I6YEA3,NCBI_GP:CCP45550.1;Name=CCP45550.1;Note=Rv2751%2C (MTV002.16)%2C len: 296 aa. Conserved protein%2Csimilar in part to others e.g. Q98LR1|MLR0915 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (299 aa)%2CFASTA scores: opt: 279%2C E(): 1.6e-11%2C (32.85%25 identity in 210 aa overlap)%3B Q9FBX1|SC8E7.10 conserved hypothetical protein from Streptomyces coelicolor (283 aa)%2C FASTA scores: opt: 232%2C E(): 2.4e-08%2C (27.9%25 identity in 269 aa overlap)%3B Q9FMY9 hypothetical protein (genomic DNA%2Cchromosome 5%2C P1 clone:MJB21) from Arabidopsis thaliana (Mouse-ear cress) (370 aa)%2C FASTA scores: opt: 205%2C E(): 2.1e-06%2C (28.9%25 identity in 211 aa overlap)%3B etc. Also similar in part to several proteins from Mycobacterium tuberculosis: P72053|Rv3787c|MTCY13D12.21 hypothetical 33.4 KDA protein (308 aa)%2C FASTA scores: opt: 266%2C E(): 1.3e-10%2C(29.6%25 identity in 267 aa overlap)%3B O53795|MBE50c|Rv0731c|MTV041.05c hypothetical 34.9 KDA protein (318 aa)%2C FASTA scores: opt: 266%2C E(): 1.3e-10%2C(32.05%25 identity in 281 aa overlap)%3B O53841|Rv0830|MTV043.22 hypothetical 33.4 KDA protein (301 aa)%2C FASTA scores: opt: 263%2C E(): 2e-10%2C (31.3%25 identity in 262 aa overlap)%3B etc. Belongs to the MTCY13D12.21 / MTCY210.45C / MTCY78.29C family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2751;product=Conserved protein;protein_id=CCP45550.1;transl_table=11
AL123456.3	EMBL	gene	3064515	3066191	.	-	.	ID=gene-Rv2752c;Name=Rv2752c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2752c
AL123456.3	EMBL	CDS	3064515	3066191	.	-	0	ID=cds-CCP45551.1;Parent=gene-Rv2752c;Dbxref=EnsemblGenomes-Gn:Rv2752c,EnsemblGenomes-Tr:CCP45551,GOA:P9WGZ9,InterPro:IPR001279,InterPro:IPR004613,InterPro:IPR011108,NCBI_GP:CCP45551.1;Name=CCP45551.1;Note=Rv2752c%2C (MTV002.17c)%2C len: 558 aa. Conserved hypothetical protein%2C equivalent to Q9CBW5|ML1512 hypothetical protein from Mycobacterium leprae (558 aa)%2CFASTA scores: opt: 3301%2C E(): 1.2e-195%2C (89.05%25 identity in 558 aa overlap). Also highly similar to other hypothetical proteins from a wide range of prokaryotes e.g. CAC19480|P54122|YOR4_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (718 aa)%2C FASTA scores: opt: 2142%2CE(): 3.5e-124%2C (57.2%25 identity in 554 aa overlap) (N-terminus longer)%3B O86842|SC9A10.09 from Streptomyces coelicolor (561 aa)%2C FASTA scores: opt: 2077%2C E(): 2.9e-120%2C (55.95%25 identity in 556 aa overlap)%3B Q9ZI80 from Streptomyces toyocaensis (528 aa)%2C FASTA scores: opt: 1843%2CE(): 7.3e-106%2C (52.45%25 identity in 528 aa overlap) (N-terminus shorter 30 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2752c;product=Conserved hypothetical protein;protein_id=CCP45551.1;transl_table=11
AL123456.3	EMBL	gene	3066222	3067124	.	-	.	ID=gene-Rv2753c;Name=dapA;gbkey=Gene;gene=dapA;gene_biotype=protein_coding;locus_tag=Rv2753c
AL123456.3	EMBL	CDS	3066222	3067124	.	-	0	ID=cds-CCP45552.1;Parent=gene-Rv2753c;Dbxref=EnsemblGenomes-Gn:Rv2753c,EnsemblGenomes-Tr:CCP45552,GOA:P9WP25,InterPro:IPR002220,InterPro:IPR005263,InterPro:IPR013785,InterPro:IPR020624,InterPro:IPR020625,PDB:1XXX,PDB:3L21,NCBI_GP:CCP45552.1;Name=CCP45552.1;Note=Rv2753c%2C (MT2823%2C MTV002.18c)%2C len: 300 aa. Probable dapA%2C dihydrodipicolinate synthase%2C equivalent to Q9CBW4|DAPA_MYCLE|ML1513 dihydrodipicolinate synthase from Mycobacterium leprae (300 aa)%2C FASTA scores: opt: 1699%2CE(): 2.2e-98%2C (86.65%25 identity in 300 aa overlap). Also highly similar to many e.g. P19808|DAPA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (301 aa)%2C FASTA scores: opt: 1089%2C E(): 2e-60%2C (58.7%25 identity in 288 aa overlap)%3B O86841|DAPA_STRCO|SC9A10.08 from Streptomyces coelicolor (299 aa)%2C FASTA scores: opt: 1044%2CE(): 1.3e-57%2C (55.75%25 identity in 287 aa overlap)%3B P05640|DAPA_ECOLI (292 aa)%2C FASTA scores: opt: 515%2C E(): 0%2C(33.8%25 identity in 287 aa overlap)%3B etc. Contains PS00665 and PS00666 Dihydrodipicolinate synthetase signatures 1 and 2. Belongs to the DHDPS family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dapA;inference=protein motif:PROSITE:PS00666;locus_tag=Rv2753c;product=Probable dihydrodipicolinate synthase DapA (DHDPS) (dihydrodipicolinate synthetase);protein_id=CCP45552.1;transl_table=11
AL123456.3	EMBL	gene	3067193	3067945	.	-	.	ID=gene-Rv2754c;Name=thyX;gbkey=Gene;gene=thyX;gene_biotype=protein_coding;locus_tag=Rv2754c
AL123456.3	EMBL	CDS	3067193	3067945	.	-	0	ID=cds-CCP45553.1;Parent=gene-Rv2754c;Dbxref=EnsemblGenomes-Gn:Rv2754c,EnsemblGenomes-Tr:CCP45553,GOA:P9WG57,InterPro:IPR003669,PDB:2AF6,PDB:2GQ2,PDB:3GWC,PDB:3HZG,NCBI_GP:CCP45553.1;Name=CCP45553.1;Note=Rv2754c%2C (MTV002.19c)%2C len: 250 aa. Probable thyX%2Cthymidylate synthase%2C highly similar to Q9CBW3|YF14_MYCLE|ML1514 thymidylate synthase from Mycobacterium leprae (254 aa)%2C FASTA scores: opt: 1351%2CE(): 1e-84%2C (81.5%25 identity in 254 aa overlap). Also highly similar to several others e.g P40111|THYX_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (250 aa)%2C FASTA scores: opt: 1080%2C E(): 9.8e-67%2C (62.85%25 identity in 245 aa overlap)%3B Q05259|THYX_BPML5 Probable thymidylate synthase from Mycobacteriophage L5 (243 aa)%2CFASTA scores: opt: 610%2C E(): 3.2e-34%2C (49.55%25 identity in 220 aa overlap)%3B etc. Contains Pfam match to entry PF02511 Thymidylate synthase complementing protein. Belongs to the THY1 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thyX;locus_tag=Rv2754c;product=Probable thymidylate synthase ThyX (ts) (TSase);protein_id=CCP45553.1;transl_table=11
AL123456.3	EMBL	gene	3068189	3068464	.	-	.	ID=gene-Rv2755c;Name=hsdS.1;gbkey=Gene;gene=hsdS.1;gene_biotype=protein_coding;gene_synonym=hsdS';locus_tag=Rv2755c
AL123456.3	EMBL	CDS	3068189	3068464	.	-	0	ID=cds-CCP45554.1;Parent=gene-Rv2755c;Dbxref=EnsemblGenomes-Gn:Rv2755c,EnsemblGenomes-Tr:CCP45554,UniProtKB/TrEMBL:I6XF84,NCBI_GP:CCP45554.1;Name=CCP45554.1;Note=Rv2755c%2C (MTV002.20c)%2C len: 91 aa. Possible hsdS.1%2Cfragment of type I restriction/modification system specificity determinant (S protein)%2C similar to the N-terminus of other hsdS proteins e.g. O34140|HSDS from Klebsiella pneumoniae (439 aa)%2C FASTA scores: opt: 303%2CE(): 2.1e-13%2C (46.65%25 identity in 90 aa overlap)%3B P72419|sty|SBLI from Salmonella typhimurium (434 aa)%2C FASTA scores: opt: 278%2C E(): 1.1e-11%2C (47.65%25 identity in 86 aa overlap)%3B and Q9P9X9|XF2741 from Xylella fastidiosa (412 aa)%2C FASTA scores: opt: 144%2C E(): 0.015%2C (31.7%25 identity in 82 aa overlap). Also some similarity with O33303|Rv2761c|MTV002.26c|HSDS possible type I restriction/modification system specificity determinant from Mycobacterium tuberculosis (364 aa)%2C FASTA scores: opt: 145%2C E(): 0.012%2C (29.9%25 identity in 87 aa overlap). Note that previously known as hsdS'.;gbkey=CDS;gene=hsdS.1;locus_tag=Rv2755c;product=Possible type I restriction/modification system specificity determinant (fragment) HsdS.1 (S protein);protein_id=CCP45554.1;transl_table=11
AL123456.3	EMBL	gene	3068461	3070083	.	-	.	ID=gene-Rv2756c;Name=hsdM;gbkey=Gene;gene=hsdM;gene_biotype=protein_coding;locus_tag=Rv2756c
AL123456.3	EMBL	CDS	3068461	3070083	.	-	0	ID=cds-CCP45555.1;Parent=gene-Rv2756c;Dbxref=EnsemblGenomes-Gn:Rv2756c,EnsemblGenomes-Tr:CCP45555,GOA:O33298,InterPro:IPR002296,InterPro:IPR003356,InterPro:IPR022749,InterPro:IPR029063,UniProtKB/TrEMBL:O33298,NCBI_GP:CCP45555.1;Name=CCP45555.1;Note=Rv2756c%2C (MTV002.21c)%2C len: 540 aa. Possible hsdM%2Ctype I restriction/modification system DNA methylase (M protein)%2C highly similar to others e.g. Q9P9X8|XF2742 from Xylella fastidiosa (519 aa)%2C FASTA scores: opt: 1613%2C E(): 1.9e-96%2C (52.3%25 identity in 543 aa overlap)%3B O34139|HSDM from Klebsiella pneumoniae (539 aa)%2C FASTA scores: opt: 1267%2C E(): 4.4e-74%2C (45.9%25 identity in 549 aa overlap)%3B P72418|sty|SBLI|HSDM from Salmonella typhimurium (539 aa)%2CFASTA scores: opt: 1263%2C E(): 8e-74%2C (45.7%25 identity in 549 aa overlap)%3B etc. Possible alternative start site (GTG) overlapping with termination codon of previous ORF 90 bp upstream. Note that the corresponding endonuclease (M protein) does not appear to be present in Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsdM;locus_tag=Rv2756c;product=Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase);protein_id=CCP45555.1;transl_table=11
AL123456.3	EMBL	gene	3070170	3070586	.	-	.	ID=gene-Rv2757c;Name=vapC21;gbkey=Gene;gene=vapC21;gene_biotype=protein_coding;locus_tag=Rv2757c
AL123456.3	EMBL	CDS	3070170	3070586	.	-	0	ID=cds-CCP45556.1;Parent=gene-Rv2757c;Dbxref=EnsemblGenomes-Gn:Rv2757c,EnsemblGenomes-Tr:CCP45556,GOA:P9WF91,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45556.1;Name=CCP45556.1;Note=Rv2757c%2C (MTV002.22c)%2C len: 138 aa. Possible vapC21%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2758c%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to several others in M. tuberculosis e.g. P96411|Rv0229c| MTCY08D5.24c (226 aa)%2C FASTA scores: opt: 354%2C E(): 4.6e-18%2C (45.25%25 identity in 137 aa overlap) (N-terminus longer 89 aa)%3B P95007|RV2546|MTCY159.10c (137 aa)%2C FASTA scores: opt: 265%2C E(): 7.5e-12%2C (38.5%25 identity in 135 aa overlap)%3B O07228|Rv0301|MTCY63.06 (141 aa)%2C FASTA scores: opt: 259%2C E(): 2.1e-11%2C (42.4%25 identity in 132 aa overlap)%3B etc.;gbkey=CDS;gene=vapC21;locus_tag=Rv2757c;product=Possible toxin VapC21;protein_id=CCP45556.1;transl_table=11
AL123456.3	EMBL	gene	3070583	3070849	.	-	.	ID=gene-Rv2758c;Name=vapB21;gbkey=Gene;gene=vapB21;gene_biotype=protein_coding;locus_tag=Rv2758c
AL123456.3	EMBL	CDS	3070583	3070849	.	-	0	ID=cds-CCP45557.1;Parent=gene-Rv2758c;Dbxref=EnsemblGenomes-Gn:Rv2758c,EnsemblGenomes-Tr:CCP45557,GOA:P9WJ43,InterPro:IPR019239,NCBI_GP:CCP45557.1;Name=CCP45557.1;Note=Rv2758c%2C (MTV002.23c)%2C len: 88 aa. Possible vapB21%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2757c (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to several others in M. tuberculosis e.g. P95008|Rv2545 (92 aa)%2C FASTA scores: opt: 151%2C E(): 0.00028%2C (66.65%25 identity in 45 aa overlap)%3B Q10771|YF60_MYCTU|RV1560|MT1611|MTCY48.05c (72 aa)%2C FASTA scores: opt: 106%2C E(): 0.52%2C (39.15%25 identity in 46 aa overlap)%3B O06565|Rv1113|MTCY22G8.02 (65 aa)%2C FASTA scores: opt: 97%2C E(): 2.2%2C (33.35%25 identity in 69 aa overlap)%3B etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.;gbkey=CDS;gene=vapB21;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2758c;product=Possible antitoxin VapB21;protein_id=CCP45557.1;transl_table=11
AL123456.3	EMBL	gene	3070875	3071270	.	-	.	ID=gene-Rv2759c;Name=vapC42;gbkey=Gene;gene=vapC42;gene_biotype=protein_coding;locus_tag=Rv2759c
AL123456.3	EMBL	CDS	3070875	3071270	.	-	0	ID=cds-CCP45558.1;Parent=gene-Rv2759c;Dbxref=EnsemblGenomes-Gn:Rv2759c,EnsemblGenomes-Tr:CCP45558,GOA:P9WF57,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45558.1;Name=CCP45558.1;Note=Rv2759c%2C (MTV002.24c)%2C len: 131 aa. Possible vapC42%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2760c%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. O07769|Y609_MYCTU|Rv0609|MT0638|MTCY19H5.13c (133 aa)%2CFASTA scores: opt: 364%2C E(): 5.1e-18%2C (49.6%25 identity in 131 aa overlap)%3B P96914|Y624_MYCTU|Rv0624|MT0652|MTCY20H10.05 (131 aa)%2CFASTA scores: opt: 324%2C E(): 2.9e-15%2C (42.85%25 identity in 126 aa overlap)%3B and Q10874|YJ82_MYCTU|Rv1982c|MT2034|MTCY39.37 (139 aa)%2C FASTA scores: opt: 271%2C E(): 1.4e-11%2C (38.6%25 identity in 127 aa overlap). Also similar to other hypothetical proteins from other bacteria e.g. CAC45376|SMC00900 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (128 aa)%2C FASTA scores: opt: 286%2C E(): 1.2e-12%2C(39.55%25 identity in 129 aa overlap)%3B Q981I7|MLL9357 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (131 aa)%2C FASTA scores: opt: 257%2C E(): 1.2e-10%2C(36.35%25 identity in 132 aa overlap)%3B Q9AAG1|CC0639 hypothetical protein from Caulobacter crescentus (131 aa)%2CFASTA scores: opt: 217%2C E(): 6.9e-08%2C (33.35%25 identity in 132 aa overlap)%3B etc.;gbkey=CDS;gene=vapC42;locus_tag=Rv2759c;product=Possible toxin VapC42. Contains PIN domain.;protein_id=CCP45558.1;transl_table=11
AL123456.3	EMBL	gene	3071267	3071536	.	-	.	ID=gene-Rv2760c;Name=vapB42;gbkey=Gene;gene=vapB42;gene_biotype=protein_coding;locus_tag=Rv2760c
AL123456.3	EMBL	CDS	3071267	3071536	.	-	0	ID=cds-CCP45559.1;Parent=gene-Rv2760c;Dbxref=EnsemblGenomes-Gn:Rv2760c,EnsemblGenomes-Tr:CCP45559,InterPro:IPR011660,NCBI_GP:CCP45559.1;Name=CCP45559.1;Note=Rv2760c%2C (MTV002.25c)%2C len: 89 aa. Possible vapB42%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2759c%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. O07770|Rv0608|MTCY19H5.14c (81 aa)%2C FASTA scores: opt: 128%2C E(): 0.057%2C (37.5%25 identity in 88 aa overlap)%3B and P96913|Rv0623|MTCY20H10.04 (84 aa)%2C FASTA scores: opt: 99%2C E(): 5.5%2C (37.1%25 identity in 89 aa overlap). Also showing some similarity with CAC45377|SMC00899 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (84 aa)%2C FASTA scores: opt: 116%2C E(): 0.38%2C (36.25%25 identity in 91 aa overlap).;gbkey=CDS;gene=vapB42;locus_tag=Rv2760c;product=Possible antitoxin VapB42;protein_id=CCP45559.1;transl_table=11
AL123456.3	EMBL	gene	3071546	3072640	.	-	.	ID=gene-Rv2761c;Name=hsdS;gbkey=Gene;gene=hsdS;gene_biotype=protein_coding;locus_tag=Rv2761c
AL123456.3	EMBL	CDS	3071546	3072640	.	-	0	ID=cds-CCP45560.1;Parent=gene-Rv2761c;Dbxref=EnsemblGenomes-Gn:Rv2761c,EnsemblGenomes-Tr:CCP45560,GOA:I6YEB1,InterPro:IPR000055,UniProtKB/TrEMBL:I6YEB1,NCBI_GP:CCP45560.1;Name=CCP45560.1;Note=Rv2761c%2C (MTV002.26c)%2C len: 364 aa. Possible hsdS%2Ctype I restriction/modification system specificity determinant (S protein)%2C similar in part to other hsdS protein (S proteins) e.g. Q9P9X9|XF2741 from Xylella fastidiosa (412 aa)%2C FASTA scores: opt: 252%2C E(): 7.4e-09%2C(24.95%25 identity in 401 aa overlap)%3B N-terminus of Q9RC12 type I S-subunit from Lactobacillus delbrueckii (subsp. lactis) (389 aa)%2C FASTA scores: opt: 232%2C E(): 1.4e-07%2C(28.1%25 identity in 185 aa overlap)%3B N-terminus of P72419|sty|SBLI from Salmonella typhimurium (434 aa)%2C FASTA scores: opt: 221%2C E(): 8e-07%2C (28.45%25 identity in 130 aa overlap)%3B C-terminus of P17222|PRRB_ECOLI from Escherichia coli strain CTR5X (401 aa)%2C FASTA scores: opt: 197%2C E(): 2.8e-05%2C (27.05%25 identity in 148 aa overlap)%3B etc. Seems to belong to type-I restriction system S methylase family.;gbkey=CDS;gene=hsdS;locus_tag=Rv2761c;product=Possible type I restriction/modification system specificity determinant HsdS (S protein);protein_id=CCP45560.1;transl_table=11
AL123456.3	EMBL	gene	3072637	3073056	.	-	.	ID=gene-Rv2762c;Name=Rv2762c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2762c
AL123456.3	EMBL	CDS	3072637	3073056	.	-	0	ID=cds-CCP45561.1;Parent=gene-Rv2762c;Dbxref=EnsemblGenomes-Gn:Rv2762c,EnsemblGenomes-Tr:CCP45561,UniProtKB/TrEMBL:I6X5B0,NCBI_GP:CCP45561.1;Name=CCP45561.1;Note=Rv2762c%2C (MTV002.27c)%2C len: 139 aa. Conserved hypothetical protein%2C similar to C-terminus of hypothetical proteins: Q9A380|CC3324 from Caulobacter crescentus (409 aa)%2C FASTA scores: opt: 181%2C E(): 9.8e-05%2C (43.55%25 identity in 101 aa overlap)%3B Q98KQ4|MLR1373 from Rhizobium loti (Mesorhizobium loti) (399 aa)%2C FASTA scores: opt: 174%2C E(): 0.00028%2C (46.35%25 identity in 82 aa overlap)%3B and Q9HZZ9|PA2844 from Pseudomonas aeruginosa (402 aa)%2C FASTA scores: opt: 158%2C E(): 0.0033%2C (40.0%25 identity in 80 aa overlap).;gbkey=CDS;locus_tag=Rv2762c;product=Conserved hypothetical protein;protein_id=CCP45561.1;transl_table=11
AL123456.3	EMBL	repeat_region	3073055	3073112	.	+	.	ID=id-AL123456.3:3073055..3073112;Note=51 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	gene	3073130	3073609	.	-	.	ID=gene-Rv2763c;Name=dfrA;gbkey=Gene;gene=dfrA;gene_biotype=protein_coding;gene_synonym=folA;locus_tag=Rv2763c
AL123456.3	EMBL	CDS	3073130	3073609	.	-	0	ID=cds-CCP45562.1;Parent=gene-Rv2763c;Dbxref=EnsemblGenomes-Gn:Rv2763c,EnsemblGenomes-Tr:CCP45562,GOA:P9WNX1,InterPro:IPR001796,InterPro:IPR012259,InterPro:IPR017925,InterPro:IPR024072,PDB:1DF7,PDB:1DG5,PDB:1DG7,PDB:1DG8,PDB:2CIG,PDB:4KL9,PDB:4KLX,PDB:4KM0,PDB:4KM2,PDB:4KNE,NCBI_GP:CCP45562.1;Name=CCP45562.1;Note=Rv2763c%2C (MTV002.28c)%2C len: 159 aa. Probable dfrA (alternate gene names: folA%2C dhfr)%2C dihydrofolate reductase%2C equivalent to O30463|FOLA dihydrofolate reductase from Mycobacterium avium (see citation below) (181 aa)%2C FASTA scores: opt: 802%2C E(): 4.5e-48%2C (70.2%25 identity in 161 aa overlap)%3B and Q9CBW1|FOLA|ML1518 dihydrofolate reductase from Mycobacterium leprae (165 aa)%2CFASTA scores: opt: 782%2C E(): 1e-46%2C (70.55%25 identity in 163 aa overlap). Also highly similar to many e.g. Q9K168|DYR_NEIMB|FOLA|NMB0308 from Neisseria meningitidis (serogroup B) (162 aa)%2C FASTA scores: opt: 469%2C E(): 3.8e-25%2C (46.65%25 identity in 163 aa overlap)%3B P12833|DYR3_SALTY|DHFRIII from Salmonella typhimurium (162 aa)%2C FASTA scores: opt: 367%2C E(): 4e-18%2C (45.4%25 identity in 141 aa overlap)%3B Q59408|DYRC_ECOLI|DHFRXIII from Escherichia coli strain RA33.2 (165 aa)%2C FASTA scores: opt: 313%2C E(): 2.2e-14%2C (41.9%25 identity in 136 aa overlap)%3B etc. Contains PS00075 Dihydrofolate reductase signature. Belongs to the dihydrofolate reductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dfrA;inference=protein motif:PROSITE:PS00075;locus_tag=Rv2763c;product=Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase);protein_id=CCP45562.1;transl_table=11
AL123456.3	EMBL	gene	3073680	3074471	.	-	.	ID=gene-Rv2764c;Name=thyA;gbkey=Gene;gene=thyA;gene_biotype=protein_coding;locus_tag=Rv2764c
AL123456.3	EMBL	CDS	3073680	3074471	.	-	0	ID=cds-CCP45563.1;Parent=gene-Rv2764c;Dbxref=EnsemblGenomes-Gn:Rv2764c,EnsemblGenomes-Tr:CCP45563,GOA:P9WFR9,InterPro:IPR000398,InterPro:IPR020940,InterPro:IPR023451,PDB:3QJ7,PDB:4FOA,PDB:4FOG,PDB:4FOX,PDB:4FQS,NCBI_GP:CCP45563.1;Name=CCP45563.1;Note=Rv2764c%2C (MTV002.29c)%2C len: 263 aa. Probable thyA%2Cthymidylate synthase%2C equivalent to Q9CBW0|TYSY_MYCLE|THYA|ML1519 thymidylate synthase from Mycobacterium leprae (266 aa)%2C FASTA scores: opt: 1602%2CE(): 5.9e-102%2C (85.5%25 identity in 262 aa overlap). Also highly similar to many e.g. P00470|TYSY_ECOLI|B2827|Z4144|ECS3684|BAB37107|AAG57938 from Escherichia coli strains K12 and O157:H7 (264 aa)%2CFASTA scores: opt: 1309%2C E(): 5.9e-82%2C (66.65%25 identity in 261 aa overlap)%3B P48464|TYSY_SHIFL|THYA from Shigella flexneri (264 aa)%2C FASTA scores: opt: 1303%2C E(): 1.5e-81%2C(65.9%25 identity in 261 aa overlap)%3B P54081|TYSB_BACAM|THYB|THYBA from Bacillus amyloliquefaciens (264 aa)%2C FASTA scores: opt: 1235%2C E(): 6.7e-77%2C (66.65%25 identity in 261 aa overlap)%3B etc. Contains PS00091 Thymidylate synthase active site. Belongs to the thymidylate synthase family.;gbkey=CDS;gene=thyA;inference=protein motif:PROSITE:PS00091;locus_tag=Rv2764c;product=Probable thymidylate synthase ThyA (ts) (TSASE);protein_id=CCP45563.1;transl_table=11
AL123456.3	EMBL	gene	3074636	3075373	.	+	.	ID=gene-Rv2765;Name=Rv2765;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2765
AL123456.3	EMBL	CDS	3074636	3075373	.	+	0	ID=cds-CCP45564.1;Parent=gene-Rv2765;Dbxref=EnsemblGenomes-Gn:Rv2765,EnsemblGenomes-Tr:CCP45564,GOA:I6XF92,InterPro:IPR002925,InterPro:IPR029058,UniProtKB/TrEMBL:I6XF92,NCBI_GP:CCP45564.1;Name=CCP45564.1;Note=Rv2765%2C (MTV002.30)%2C len: 245 aa. Probable ala-rich hydrolase%2C similar to various hydrolases or hypothetical proteins e.g. Q9KYM6|SC9H11.13c putative hydrolase from Streptomyces coelicolor (251 aa)%2C FASTA scores: opt: 630%2CE(): 1.4e-33%2C (43.1%25 identity in 246 aa overlap)%3B Q9A5T9|CC2358 dienelactone hydrolase family protein from Caulobacter crescentus (286 aa)%2C FASTA scores: opt: 592%2CE(): 4.5e-31%2C (38.45%25 identity in 242 aa overlap)%3B Q9FCF1|2SCD46.33 putative hydrolase (dienelactone hydrolase family) from Streptomyces coelicolor (254 aa)%2C FASTA scores: opt: 500%2C E(): 3.9e-25%2C (37.7%25 identity in 252 aa overlap)%3B P73163|DLHH_SYNY3|SLL1298 putative carboxymethylenebutenolidase (dienelactone hydrolase) from Synechocystis sp. (strain PCC 6803) (246 aa)%2C FASTA scores: opt: 276%2C E(): 1.3e-10%2C (26.95%25 identity in 230 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2765;product=Probable alanine rich hydrolase;protein_id=CCP45564.1;transl_table=11
AL123456.3	EMBL	gene	3075588	3076370	.	-	.	ID=gene-Rv2766c;Name=Rv2766c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2766c
AL123456.3	EMBL	CDS	3075588	3076370	.	-	0	ID=cds-CCP45565.1;Parent=gene-Rv2766c;Dbxref=EnsemblGenomes-Gn:Rv2766c,EnsemblGenomes-Tr:CCP45565,GOA:I6YEB6,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:I6YEB6,NCBI_GP:CCP45565.1;Name=CCP45565.1;Note=Rv2766c%2C (MTV002.31c)%2C len: 260 aa. Probable short-chain dehydrogenase/reductase %2C similar to others (from bacteria and eukaryota) e.g. Q9K3Y8|2SCG61.27c putative short chain oxidoreductase from Streptomyces coelicolor (253 aa)%2C FASTA scores: opt: 722%2C E(): 7.4e-39%2C(44.75%25 identity in 248 aa overlap)%3B Q93790|F54F3.4 hypothetical SDR protein from Caenorhabditis elegans (260 aa)%2C FASTA scores: opt: 613%2C E(): 6.9e-32%2C (41.7%25 identity in 247 aa overlap)%3B O95162|O95162|scad-SRL peroxisomal short-chain alcohol dehydrogenase from Homo sapiens (Human) (260 aa)%2C FASTA scores: opt: 594%2C E(): 1.1e-30%2C (39.6%25 identity in 250 aa overlap)%3B P51831|FABG_BACSU 3-oxoacyl-[acyl-carrier protein] from Bacillus subtilis (246 aa)%2C FASTA scores: opt: 504%2C E(): 4e-28%2C (37.2%25 identity in 247 aa overlap)%3B etc. Also similar to many other Mycobacterium tuberculosis acyl-carrier proteins e.g. MTCY03C7.07 (38.5%25 identity in 244 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Note that previously known as fabG5%2C a 3-oxoacyl-[acyl-carrier-protein].;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv2766c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP45565.1;transl_table=11
AL123456.3	EMBL	gene	3076367	3076720	.	-	.	ID=gene-Rv2767c;Name=Rv2767c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2767c
AL123456.3	EMBL	CDS	3076367	3076720	.	-	0	ID=cds-CCP45566.1;Parent=gene-Rv2767c;Dbxref=EnsemblGenomes-Gn:Rv2767c,EnsemblGenomes-Tr:CCP45566,UniProtKB/TrEMBL:O33309,NCBI_GP:CCP45566.1;Name=CCP45566.1;Note=Rv2767c%2C (MTV002.32c)%2C len: 117 aa (questionable ORF). Possible membrane protein%2C showing very weak similarity with Q9L2H7|SCC121.09 putative metal transport ABC transporter from Streptomyces coelicolor (256 aa)%2CFASTA scores: opt: 110%2C E(): 1%2C (33.05%25 identity in 112 aa overlap).;gbkey=CDS;locus_tag=Rv2767c;product=Possible membrane protein;protein_id=CCP45566.1;transl_table=11
AL123456.3	EMBL	gene	3076894	3078078	.	-	.	ID=gene-Rv2768c;Name=PPE43;gbkey=Gene;gene=PPE43;gene_biotype=protein_coding;locus_tag=Rv2768c
AL123456.3	EMBL	CDS	3076894	3078078	.	-	0	ID=cds-CCP45567.1;Parent=gene-Rv2768c;Dbxref=EnsemblGenomes-Gn:Rv2768c,EnsemblGenomes-Tr:CCP45567,InterPro:IPR000030,InterPro:IPR022171,UniProtKB/TrEMBL:Q79FA9,NCBI_GP:CCP45567.1;Name=CCP45567.1;Note=Rv2768c%2C (MTV002.33c)%2C len: 394 aa. PPE43%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. upstream ORF O33312|Rv2770c|MTV002.35c (402 aa)%2C FASTA scores: opt: 1135%2C E(): 6.1e-51%2C (62.15%25 identity in 391 aa overlap)%3B and P96362|Rv1039c|MTCY10G2.10 from M. tuberculosis (391 aa)%2C FASTA scores: opt: 1721%2CE(): 6.8e-81%2C (70.35%25 identity in 398 aa overlap). Equivalent to AAK47157 from Mycobacterium tuberculosis strain CDC1551 (462 aa) but shorter 68 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE43;locus_tag=Rv2768c;product=PPE family protein PPE43;protein_id=CCP45567.1;transl_table=11
AL123456.3	EMBL	gene	3078158	3078985	.	-	.	ID=gene-Rv2769c;Name=PE27;gbkey=Gene;gene=PE27;gene_biotype=protein_coding;locus_tag=Rv2769c
AL123456.3	EMBL	CDS	3078158	3078985	.	-	0	ID=cds-CCP45568.1;Parent=gene-Rv2769c;Dbxref=EnsemblGenomes-Gn:Rv2769c,EnsemblGenomes-Tr:CCP45568,InterPro:IPR000084,InterPro:IPR022171,UniProtKB/TrEMBL:Q79FA8,NCBI_GP:CCP45568.1;Name=CCP45568.1;Note=Rv2769c%2C (MTV002.34c)%2C len: 275 aa. PE27%2C Member of the Mycobacterium tuberculosis PE family (see citation below)%2C highly similar to many (notably in N-terminal part) e.g. P96361|Rv1040c|MTCY10G2.09 from Mycobacterium tuberculosis (275 aa)%2C FASTA scores: opt: 1111%2C E(): 5.9e-52%2C (68.55%25 identity in 283 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE27;locus_tag=Rv2769c;product=PE family protein PE27;protein_id=CCP45568.1;transl_table=11
AL123456.3	EMBL	gene	3079309	3080457	.	-	.	ID=gene-Rv2770c;Name=PPE44;gbkey=Gene;gene=PPE44;gene_biotype=protein_coding;locus_tag=Rv2770c
AL123456.3	EMBL	CDS	3079309	3080457	.	-	0	ID=cds-CCP45569.1;Parent=gene-Rv2770c;Dbxref=EnsemblGenomes-Gn:Rv2770c,EnsemblGenomes-Tr:CCP45569,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP45569.1;Name=CCP45569.1;Note=Rv2770c%2C (MTV002.35c)%2C len: 382 aa. PPE44%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. downstream ORF O33310|Rv2768c|MTV002.33c from M. tuberculosis (394 aa)%2C FASTA scores: opt: 1135%2C E(): 2.2e-53%2C (62.15%25 identity in 391 aa overlap)%3B and P96362|Rv1039c|MTCY10G2.10 from Mycobacterium tuberculosis (391 aa)%2C FASTA scores: opt: 1010%2C E(): 1e-46%2C (55.95%25 identity in 395 aa overlap). Equivalent to AAK47159 from Mycobacterium tuberculosis strain CDC1551 (402 aa) but shorter 20 aa. Start changed since first submission (-20 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE44;locus_tag=Rv2770c;product=PPE family protein PPE44;protein_id=CCP45569.1;transl_table=11
AL123456.3	EMBL	gene	3080581	3081033	.	-	.	ID=gene-Rv2771c;Name=Rv2771c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2771c
AL123456.3	EMBL	CDS	3080581	3081033	.	-	0	ID=cds-CCP45570.1;Parent=gene-Rv2771c;Dbxref=EnsemblGenomes-Gn:Rv2771c,EnsemblGenomes-Tr:CCP45570,GOA:O33313,InterPro:IPR005025,InterPro:IPR029039,UniProtKB/TrEMBL:O33313,NCBI_GP:CCP45570.1;Name=CCP45570.1;Note=Rv2771c%2C (MTV002.36c)%2C len: 150 aa. Conserved hypothetical protein%2C equivalent to Q9CBV8|ML1525 hypothetical protein from Mycobacterium leprae (151 aa)%2CFASTA scores: opt: 489%2C E(): 1.7e-27%2C (52.7%25 identity in 148 aa overlap). Also highly similar to Q9RD46|SCF56.21 hypothetical 15.7 KDA protein from Streptomyces coelicolor (151 aa)%2C FASTA scores: opt: 671%2C E(): 2.2e-40%2C (67.8%25 identity in 146 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2771c;product=Conserved hypothetical protein;protein_id=CCP45570.1;transl_table=11
AL123456.3	EMBL	gene	3081119	3081592	.	-	.	ID=gene-Rv2772c;Name=Rv2772c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2772c
AL123456.3	EMBL	CDS	3081119	3081592	.	-	0	ID=cds-CCP45571.1;Parent=gene-Rv2772c;Dbxref=EnsemblGenomes-Gn:Rv2772c,EnsemblGenomes-Tr:CCP45571,GOA:I6YA75,UniProtKB/TrEMBL:I6YA75,NCBI_GP:CCP45571.1;Name=CCP45571.1;Note=Rv2772c%2C (MTV002.37c)%2C len: 157 aa. Probable conserved transmembrane protein%2C equivalent to Q9CBV7|ML1526 conserved membrane protein from Mycobacterium leprae (160 aa)%2C FASTA scores: opt: 767%2C E(): 1.5e-43%2C(76.6%25 identity in 154 aa overlap)%3B and similar to P46830|YDAB_MYCBO from Mycobacterium bovis (177 aa)%2C FASTA scores: opt: 337%2C E(): 3.9e-15%2C (40.75%25 identity in 135 aa overlap). Also similar to O86837|SC9A10.04 putative membrane protein from Streptomyces coelicolor (151 aa)%2CFASTA scores: opt: 338%2C E(): 3e-15%2C (43.75%25 identity in 144 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2772c;product=Probable conserved transmembrane protein;protein_id=CCP45571.1;transl_table=11
AL123456.3	EMBL	gene	3081604	3082341	.	-	.	ID=gene-Rv2773c;Name=dapB;gbkey=Gene;gene=dapB;gene_biotype=protein_coding;locus_tag=Rv2773c
AL123456.3	EMBL	CDS	3081604	3082341	.	-	0	ID=cds-CCP45572.1;Parent=gene-Rv2773c;Dbxref=EnsemblGenomes-Gn:Rv2773c,EnsemblGenomes-Tr:CCP45572,GOA:P9WP23,InterPro:IPR000846,InterPro:IPR011770,InterPro:IPR016040,InterPro:IPR022663,InterPro:IPR022664,InterPro:IPR023940,PDB:1C3V,PDB:1P9L,PDB:1YL5,PDB:1YL6,PDB:1YL7,NCBI_GP:CCP45572.1;Name=CCP45572.1;Note=Rv2773c%2C (MTV002.38c)%2C len: 245 aa. DapB%2Cdihydrodipicolinate reductase (see Pavelka et al.%2C 1997)%2Chighly similar to many e.g. P40110|DAPB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (248 aa)%2C FASTA scores: opt: 1030%2C E(): 1.8e-58%2C (65.45%25 identity in 246 aa overlap)%3B O86836|DAPB_STRCO|SC9A10.03 from Streptomyces coelicolor (250 aa)%2C FASTA scores: opt: 997%2C E(): 2.3e-56%2C (61.15%25 identity in 247 aa overlap)%3B P42976|DAPB_BACSU from Bacillus subtilis (267 aa)%2C FASTA scores: opt: 608%2C E(): 1.7e-31%2C (45.95%25 identity in 209 aa overlap)%3B P46829|DAPB_MYCBO from Mycobacterium bovis (see Cirillo et al.%2C 1994) (271 aa)%2C FASTA scores: opt: 505%2CE(): 6.3e-25%2C (36.2%25 identity in 246 aa overlap)%3B etc. Belongs to the dihydrodipicolinate reductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dapB;locus_tag=Rv2773c;product=Dihydrodipicolinate reductase DapB (DHPR);protein_id=CCP45572.1;transl_table=11
AL123456.3	EMBL	gene	3082352	3082756	.	-	.	ID=gene-Rv2774c;Name=Rv2774c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2774c
AL123456.3	EMBL	CDS	3082352	3082756	.	-	0	ID=cds-CCP45573.1;Parent=gene-Rv2774c;Dbxref=EnsemblGenomes-Gn:Rv2774c,EnsemblGenomes-Tr:CCP45573,UniProtKB/TrEMBL:O33316,NCBI_GP:CCP45573.1;Name=CCP45573.1;Note=Rv2774c%2C (MTV002.39c)%2C len: 134 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2774c;product=Hypothetical protein;protein_id=CCP45573.1;transl_table=11
AL123456.3	EMBL	gene	3082909	3083370	.	+	.	ID=gene-Rv2775;Name=Rv2775;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2775
AL123456.3	EMBL	CDS	3082909	3083370	.	+	0	ID=cds-CCP45574.1;Parent=gene-Rv2775;Dbxref=EnsemblGenomes-Gn:Rv2775,EnsemblGenomes-Tr:CCP45574,GOA:O33317,InterPro:IPR000182,InterPro:IPR016181,UniProtKB/TrEMBL:O33317,NCBI_GP:CCP45574.1;Name=CCP45574.1;Note=Rv2775%2C (MTV002.40)%2C len: 153 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Showing weak similarity to other hypothetical proteins e.g. Q9ZBJ7|SC9C7.13c from Streptomyces coelicolor (179 aa)%2CFASTA scores: opt: 167%2C E(): 0.00024%2C (29.05%25 identity in 148 aa overlap). Equivalent to AAK47164 from Mycobacterium tuberculosis strain CDC1551 (185 aa) but shorter 32 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2775;product=GCN5-related N-acetyltransferase;protein_id=CCP45574.1;transl_table=11
AL123456.3	EMBL	gene	3083374	3084303	.	-	.	ID=gene-Rv2776c;Name=Rv2776c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2776c
AL123456.3	EMBL	CDS	3083374	3084303	.	-	0	ID=cds-CCP45575.1;Parent=gene-Rv2776c;Dbxref=EnsemblGenomes-Gn:Rv2776c,EnsemblGenomes-Tr:CCP45575,GOA:O86347,InterPro:IPR000951,InterPro:IPR001041,InterPro:IPR001433,InterPro:IPR006058,InterPro:IPR008333,InterPro:IPR012675,InterPro:IPR017927,InterPro:IPR017938,UniProtKB/TrEMBL:O86347,NCBI_GP:CCP45575.1;Name=CCP45575.1;Note=Rv2776c%2C (MTV002.41c)%2C len: 309 aa. Probable oxidoreductase%2C similar to other oxidoreductases e.g. Q9KZ15|SC10B7.17 putative iron-sulfur oxidoreductase from Streptomyces coelicolor (364 aa)%2C FASTA scores: opt: 846%2CE(): 1.2e-45%2C (46.75%25 identity in 308 aa overlap)%3B O88034|SC5A7.28c iron-sulfur oxidoreductase beta subunit from Streptomyces coelicolor (313 aa)%2C FASTA scores: opt: 745%2C E(): 2.3e-39%2C (41.45%25 identity in 316 aa overlap)%3B P33164|PDR_BURCE|OPHA1 phthalate dioxygenase reductase from Burkholderia cepacia (Pseudomonas cepacia) (321 aa)%2C FASTA scores: opt: 616%2C E(): 2.9e-31%2C (33.65%25 identity in 309 aa overlap)%3B etc. Equivalent to AAK47165 from Mycobacterium tuberculosis strain CDC1551 (363 aa) but shorter 54 aa. Contains PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature and PS00063 Aldo/keto reductase family putative active site signature. Seems to belong to the 2FE2S plant-type ferredoxin family in the C-terminal section.;gbkey=CDS;inference=protein motif:PROSITE:PS00197;locus_tag=Rv2776c;product=Probable oxidoreductase;protein_id=CCP45575.1;transl_table=11
AL123456.3	EMBL	gene	3084485	3085555	.	-	.	ID=gene-Rv2777c;Name=Rv2777c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2777c
AL123456.3	EMBL	CDS	3084485	3085555	.	-	0	ID=cds-CCP45576.1;Parent=gene-Rv2777c;Dbxref=EnsemblGenomes-Gn:Rv2777c,EnsemblGenomes-Tr:CCP45576,InterPro:IPR016516,UniProtKB/TrEMBL:O33319,NCBI_GP:CCP45576.1;Name=CCP45576.1;Note=Rv2777c%2C (MTV002.42c)%2C len: 356 aa. Conserved hypothetical protein%2C highly similar (but longer in N-terminus) to hypothetical proteins Q9KZ16|SC10B7.16 from Streptomyces coelicolor (296 aa)%2C FASTA scores: opt: 980%2CE(): 6.8e-57%2C (51.25%25 identity in 281 aa overlap)%3B and Q9HYS0|PA3325 from Pseudomonas aeruginosa (295 aa)%2C FASTA scores: opt: 816%2C E(): 4e-46%2C (43.75%25 identity in 288 aa overlap)%3B and similar (but longer in N-terminus) to other hypothetical proteins e.g. Q9I3H1|PA1542 from Pseudomonas aeruginosa (278 aa)%2C FASTA scores: opt: 234%2C E(): 6.3e-08%2C(31.8%25 identity in 258 aa overlap). Equivalent to AAK47166 from Mycobacterium tuberculosis strain CDC1551 (393 aa) but shorter 37 aa.;gbkey=CDS;locus_tag=Rv2777c;product=Conserved hypothetical protein;protein_id=CCP45576.1;transl_table=11
AL123456.3	EMBL	gene	3085713	3086183	.	-	.	ID=gene-Rv2778c;Name=Rv2778c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2778c
AL123456.3	EMBL	CDS	3085713	3086183	.	-	0	ID=cds-CCP45577.1;Parent=gene-Rv2778c;Dbxref=EnsemblGenomes-Gn:Rv2778c,EnsemblGenomes-Tr:CCP45577,InterPro:IPR019587,InterPro:IPR023393,UniProtKB/TrEMBL:I6Y1P2,NCBI_GP:CCP45577.1;Name=CCP45577.1;Note=Rv2778c%2C (MTV002.43c)%2C len: 156 aa. Conserved protein%2C similar to Q9CBF7|ML2031 hypothetical protein from Mycobacterium leprae (151 aa)%2C FASTA scores: opt: 227%2C E(): 8.5e-09%2C (35.95%25 identity in 153 aa overlap). Also similar to AAK46204|MT1931.1 hypothetical 17.8 KDA protein from Mycobacterium tuberculosis strain CDC1551 (158 aa)%2C FASTA scores: opt: 238%2C E(): 1.5e-09%2C (35.75%25 identity in 151 aa overlap)%3B or O07748|Rv1883c|MTCY180.35 hypothetical 17.3 KDA protein from Mycobacterium tuberculosis strain H37Rv (158 aa)%2C FASTA scores: opt: 212%2C E(): 9.7e-08%2C (34.45%25 identity in 151 aa overlap)%3B note that AAK46204|MT1931.1 and O07748|Rv1883c|MTCY180.35 are essentially the same protein except for a small (5 aa) gap.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2778c;product=Conserved protein;protein_id=CCP45577.1;transl_table=11
AL123456.3	EMBL	gene	3086215	3086754	.	-	.	ID=gene-Rv2779c;Name=Rv2779c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2779c
AL123456.3	EMBL	CDS	3086215	3086754	.	-	0	ID=cds-CCP45578.1;Parent=gene-Rv2779c;Dbxref=EnsemblGenomes-Gn:Rv2779c,EnsemblGenomes-Tr:CCP45578,GOA:O33321,InterPro:IPR000485,InterPro:IPR011008,InterPro:IPR011991,InterPro:IPR019887,InterPro:IPR019888,UniProtKB/TrEMBL:O33321,NCBI_GP:CCP45578.1;Name=CCP45578.1;Note=Rv2779c%2C (MTV002.44c)%2C len: 179 aa. Possible transcriptional regulator%2C from the Lrp/AsnC family%2Csimilar (but longer ~~30 aa in N-terminus) to others e.g. CAC42842|SCBAC36F5.06 putative AsnC-family transcriptional regulatory protein from Streptomyces coelicolor (163 aa)%2CFASTA scores: opt: 333%2C E(): 4.4e-16%2C (39.7%25 identity in 141 aa overlap)%3B O07920|AZLB_BACSU transcriptional regulator (AsnC family) from Bacillus subtilis%3B Q9I233|PA2082 probable transcriptional regulator (AsnC family) from Pseudomonas aeruginosa (158 aa)%2C FASTA scores: opt: 322%2C E(): 2.5e-15%2C (33.1%25 identity in 148 aa overlap)%3B etc. Also similar to P96896|Rv3291c|MTCY71.31c from Mycobacterium tuberculosis (33.3%25 identity in 120 aa overlap). Equivalent to AAK47168 from Mycobacterium tuberculosis strain CDC1551 (181 aa). Seems to belong to the AsnC family of transcriptional regulators. Start changed since first submission (+8 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2779c;product=Possible transcriptional regulatory protein (probably Lrp/AsnC-family);protein_id=CCP45578.1;transl_table=11
AL123456.3	EMBL	gene	3086820	3087935	.	+	.	ID=gene-Rv2780;Name=ald;gbkey=Gene;gene=ald;gene_biotype=protein_coding;locus_tag=Rv2780
AL123456.3	EMBL	CDS	3086820	3087935	.	+	0	ID=cds-CCP45579.1;Parent=gene-Rv2780;Dbxref=EnsemblGenomes-Gn:Rv2780,EnsemblGenomes-Tr:CCP45579,GOA:P9WQB1,InterPro:IPR007698,InterPro:IPR007886,InterPro:IPR008141,InterPro:IPR008142,InterPro:IPR008143,InterPro:IPR016040,PDB:2VHV,PDB:2VHW,PDB:2VHX,PDB:2VHY,PDB:2VHZ,PDB:2VOE,PDB:2VOJ,NCBI_GP:CCP45579.1;Name=CCP45579.1;Note=Rv2780%2C (MT2850%2C MTV002.45)%2C len: 371 aa. Ald%2Csecreted L-alanine dehydrogenase (40 kd antigen)%3B equivalent to Q9CBV6|ALD|ML1532 L-alanine dehydrogenase from Mycobacterium leprae (371 aa)%2C FASTA scores: opt: 2081%2C E(): 4e-115%2C (85.45%25 identity in 371 aa overlap). Also highly similar to others e.g. Q9S227|SCI51.13c from Streptomyces coelicolor (371 aa)%2C FASTA scores: opt: 1575%2CE(): 2.3e-85%2C (66.05%25 identity in 371 aa overlap)%3B Q9K827|BH3180 from Bacillus halodurans (371 aa)%2C FASTA scores: opt: 1341%2C E(): 1.4e-71%2C (56.45%25 identity in 372 aa overlap)%3B Q9RT70|DR1895 from Deinococcus radiodurans (390 aa)%2C FASTA scores: opt: 1319%2C E(): 2.8e-70%2C (54.2%25 identity in 371 aa overlap)%3B etc. Contains PS00836 and PS00837 Alanine dehydrogenase %26 pyridine nucleotide transhydrogenase signature 1 and 2. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ald;inference=protein motif:PROSITE:PS00837;locus_tag=Rv2780;product=Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43);protein_id=CCP45579.1;transl_table=11
AL123456.3	EMBL	gene	3087950	3088984	.	-	.	ID=gene-Rv2781c;Name=Rv2781c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2781c
AL123456.3	EMBL	CDS	3087950	3088984	.	-	0	ID=cds-CCP45580.1;Parent=gene-Rv2781c;Dbxref=EnsemblGenomes-Gn:Rv2781c,EnsemblGenomes-Tr:CCP45580,GOA:I6X5C5,InterPro:IPR004136,InterPro:IPR013785,UniProtKB/TrEMBL:I6X5C5,NCBI_GP:CCP45580.1;Name=CCP45580.1;Note=Rv2781c%2C (MTV002.46c)%2C len: 344 aa. Possible ala-rich oxidoreductase%2C similar to various oxidoreductases or hypothetical proteins e.g. Q9RDD8|SCC77.20c putative oxidoreductase from Streptomyces coelicolor (364 aa)%2C FASTA scores: opt: 912%2C E(): 5.3e-47%2C (45.55%25 identity in 336 aa overlap)%3B Q9FDD4|2-NPDL putative 2-nitropropane dioxygenase from Streptomyces ansochromogenes (363 aa)%2C FASTA scores: opt: 869%2C E(): 1.9e-44%2C (44.2%25 identity in 337 aa overlap)%3B O05413|YRPB 2-nitropropane dioxygenase from Bacillus subtilis (347 aa)%2C FASTA scores: opt: 560%2C E(): 4.9e-26%2C(33.75%25 identity in 317 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2781c;product=Possible alanine rich oxidoreductase;protein_id=CCP45580.1;transl_table=11
AL123456.3	EMBL	gene	3089045	3090361	.	-	.	ID=gene-Rv2782c;Name=pepR;gbkey=Gene;gene=pepR;gene_biotype=protein_coding;locus_tag=Rv2782c
AL123456.3	EMBL	CDS	3089045	3090361	.	-	0	ID=cds-CCP45581.1;Parent=gene-Rv2782c;Dbxref=EnsemblGenomes-Gn:Rv2782c,EnsemblGenomes-Tr:CCP45581,GOA:P9WHT5,InterPro:IPR001431,InterPro:IPR007863,InterPro:IPR011237,InterPro:IPR011249,InterPro:IPR011765,NCBI_GP:CCP45581.1;Name=CCP45581.1;Note=Rv2782c%2C (MTV002.47c)%2C len: 438 aa. Probable pepR%2Cprotease/peptidase%2C equivalent to O32965|YR82_MYCLE|ML0855|MLCB22.26c hypothetical zinc protease from Mycobacterium leprae (445 aa)%2C FASTA scores: opt: 2346%2C E(): 4.3e-146%2C (84.3%25 identity in 421 aa overlap). Also highly similar to others e.g. O86835|YA12_STRCO|SC9A10.02 from Streptomyces coelicolor (459 aa)%2C FASTA scores: opt: 1394%2C E(): 1.1e-83%2C (51.9%25 identity in 416 aa overlap)%3B Q04805|YMXG_BACSU|YMXG from Bacillus subtilis (409 aa)%2C FASTA scores: opt: 1014%2C E(): 7.9e-59%2C (37.55%25 identity in 410 aa overlap)%3B Q9KA85|BH2405 from Bacillus halodurans (413 aa)%2C FASTA scores: opt: 967%2CE(): 9.6e-56%2C (38.6%25 identity in 417 aa overlap)%3B etc. Contains PS00143 Insulinase family%2C zinc-binding region signature. Belongs to peptidase family M16%2C also known as the insulinase family. Cofactor: requires divalent cations for activity. Binds zinc. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pepR;inference=protein motif:PROSITE:PS00143;locus_tag=Rv2782c;product=Probable zinc protease PepR;protein_id=CCP45581.1;transl_table=11
AL123456.3	EMBL	gene	3090339	3092597	.	-	.	ID=gene-Rv2783c;Name=gpsI;gbkey=Gene;gene=gpsI;gene_biotype=protein_coding;locus_tag=Rv2783c
AL123456.3	EMBL	CDS	3090339	3092597	.	-	0	ID=cds-CCP45582.1;Parent=gene-Rv2783c;Dbxref=EnsemblGenomes-Gn:Rv2783c,EnsemblGenomes-Tr:CCP45582,GOA:P9WI57,InterPro:IPR001247,InterPro:IPR003029,InterPro:IPR004087,InterPro:IPR004088,InterPro:IPR012162,InterPro:IPR012340,InterPro:IPR014069,InterPro:IPR015847,InterPro:IPR015848,InterPro:IPR020568,InterPro:IPR022967,InterPro:IPR027408,NCBI_GP:CCP45582.1;Name=CCP45582.1;Note=Rv2783c%2C (MTV002.48c)%2C len: 752 aa. Probable gpsI%2Cpolyribonucleotide nucleotidyltransferase%2C equivalent to Q9CCF8|GPSI|ML0854 (alias O32966) putative polyribonucleotide phosphorylase / guanosine pentaphosphate synthetase from Mycobacterium leprae (773 aa)%2C FASTA scores: opt: 4304%2C E(): 0%2C (89.95%25 identity in 757 aa overlap). Also highly similar to others e.g. O86656|GPSI guanosine pentaphosphate synthetase/ polyribonucleotide nucleotidyltransferase (fragment) from Streptomyces coelicolor (716 aa)%2C FASTA scores: opt: 3393%2C E(): 5.8e-192%2C (72.77%25 identity in 718 aa overlap)%3B Q53597|GPSI guanosine pentaphosphate synthetase from Streptomyces antibioticus (740 aa)%2C FASTA scores: opt: 3314%2C E(): 2.6e-187%2C (70.55%25 identity in 733 aa overlap)%3B P72659|PNP|SLL1043 polyribonucleotide nucleotidyltransferase from Synechocystis sp. strain PCC 6803 (718 aa)%2C FASTA scores: opt: 1244%2C E(): 1.7e-65%2C(45.05%25 identity in 750 aa overlap)%3B etc. Note that S. antibioticus guanosine pentaphosphate synthetase is a multifunctional enzyme that also acts as a polyribonucleotide nucleotidyltransferase. Start site chosen by homology from several alternatives.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gpsI;locus_tag=Rv2783c;product=Bifunctional protein polyribonucleotide nucleotidyltransferase GpsI: guanosine pentaphosphate synthetase + polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) (pnpase);protein_id=CCP45582.1;transl_table=11
AL123456.3	EMBL	gene	3092951	3093466	.	-	.	ID=gene-Rv2784c;Name=lppU;gbkey=Gene;gene=lppU;gene_biotype=protein_coding;locus_tag=Rv2784c
AL123456.3	EMBL	CDS	3092951	3093466	.	-	0	ID=cds-CCP45583.1;Parent=gene-Rv2784c;Dbxref=EnsemblGenomes-Gn:Rv2784c,EnsemblGenomes-Tr:CCP45583,UniProtKB/TrEMBL:I6XFA6,NCBI_GP:CCP45583.1;Name=CCP45583.1;Note=Rv2784c%2C (MTV002.49c)%2C len: 171 aa. Probable lppU%2Clipoprotein%2C sharing no homology with other proteins. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppU;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2784c;product=Probable lipoprotein LppU;protein_id=CCP45583.1;transl_table=11
AL123456.3	EMBL	gene	3093479	3093748	.	-	.	ID=gene-Rv2785c;Name=rpsO;gbkey=Gene;gene=rpsO;gene_biotype=protein_coding;locus_tag=Rv2785c
AL123456.3	EMBL	CDS	3093479	3093748	.	-	0	ID=cds-CCP45584.1;Parent=gene-Rv2785c;Dbxref=EnsemblGenomes-Gn:Rv2785c,EnsemblGenomes-Tr:CCP45584,GOA:P9WH55,InterPro:IPR000589,InterPro:IPR005290,InterPro:IPR009068,NCBI_GP:CCP45584.1;Name=CCP45584.1;Note=Rv2785c%2C (MTV002.50c)%2C len: 89 aa. rpsO%2C 30s ribosomal protein S15%2C equivalent to O32967|RS15_MYCLE|RPSO|ML0853|MLCB22.28c 30S ribosomal protein S15 from Mycobacterium leprae (89 aa)%2C FASTA scores: opt: 522%2C E(): 7.4e-34%2C (92.15%25 identity in 89 aa overlap). Also highly similar to many e.g. O86655|RS15_STRCO|RPSO|SC3C3.22 from Streptomyces coelicolor (95 aa)%2C FASTA scores: opt: 408%2C E(): 6.7e-25%2C(62.9%25 identity in 89 aa overlap)%3B P05766|RS15_BACST|RPSO from Bacillus stearothermophilus (88 aa)%2C FASTA scores: opt: 385%2C E(): 4e-23%2C (62.5%25 identity in 88 aa overlap)%3B P21473|RS15_BACSU|RPSO from Bacillus subtilis (88 aa)%2CFASTA scores: opt: 351%2C E(): 1.9e-20%2C (57.95%25 identity in 88 aa overlap)%3B P02371|RS15_ECOLI|RPSO|sec|B3165 from Escherichia coli strain K12 (88 aa)%2C FASTA scores: opt: 295%2C E(): 4.5e-22%2C (52.3%25 identity in 88 aa overlap)%3B etc. Contains PS00362 Ribosomal protein S15 signature. Belongs to the S15P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsO;inference=protein motif:PROSITE:PS00362;locus_tag=Rv2785c;product=30S ribosomal protein S15 RpsO;protein_id=CCP45584.1;transl_table=11
AL123456.3	EMBL	gene	3093905	3094900	.	-	.	ID=gene-Rv2786c;Name=ribF;gbkey=Gene;gene=ribF;gene_biotype=protein_coding;locus_tag=Rv2786c
AL123456.3	EMBL	CDS	3093905	3094900	.	-	0	ID=cds-CCP45585.1;Parent=gene-Rv2786c;Dbxref=EnsemblGenomes-Gn:Rv2786c,EnsemblGenomes-Tr:CCP45585,GOA:I6X5C9,InterPro:IPR002606,InterPro:IPR014729,InterPro:IPR015864,InterPro:IPR015865,InterPro:IPR023465,InterPro:IPR023468,UniProtKB/TrEMBL:I6X5C9,NCBI_GP:CCP45585.1;Name=CCP45585.1;Note=Rv2786c%2C (MTV002.51c)%2C len: 331 aa. Probable ribF%2CFAD synthetase/riboflavin biosynthesis protein%2Cbifunctional enzyme%2C equivalent to O32968|RIBF|ML0852 riboflavin kinase from Mycobacterium leprae (331 aa)%2C FASTA scores: opt: 1923%2C E(): 2.3e-115%2C (87.45%25 identity in 327 aa overlap). Also highly similar to many e.g. Q59263|RIBF_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (338 aa)%2C FASTA scores: opt: 899%2C E(): 5.7e-50%2C (45.8%25 identity in 321 aa overlap)%3B Q9Z530|SC9F2.05c from Streptomyces coelicolor (318 aa)%2CFASTA scores: opt: 862%2C E(): 1.3e-47%2C (52.45%25 identity in 324 aa overlap)%3B P08391|RIBF_ECOLI|B0025|Z0029\ECS0028 from Escherichia coli strains K12 and O157:H7 (313 aa)%2C FASTA scores: opt: 517%2C E(): 1.3e-25%2C (36.05%25 identity in 305 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ribF;locus_tag=Rv2786c;product=Probable bifunctional FAD synthetase/riboflavin biosynthesis protein RibF: riboflavin kinase (flavokinase) + FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)(FAD diphosphorylase) (flavin adenine dinucleotide synthetase);protein_id=CCP45585.1;transl_table=11
AL123456.3	EMBL	gene	3095111	3096874	.	+	.	ID=gene-Rv2787;Name=Rv2787;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2787
AL123456.3	EMBL	CDS	3095111	3096874	.	+	0	ID=cds-CCP45586.1;Parent=gene-Rv2787;Dbxref=EnsemblGenomes-Gn:Rv2787,EnsemblGenomes-Tr:CCP45586,GOA:O33329,InterPro:IPR002586,InterPro:IPR011990,InterPro:IPR027417,UniProtKB/TrEMBL:O33329,NCBI_GP:CCP45586.1;Name=CCP45586.1;Note=Rv2787%2C (MTV002.52)%2C len: 587 aa. Conserved hypothetical ala-rich protein%2C equivalent to Q9CCI1|ML0798 hypothetical protein from Mycobacterium leprae (592 aa)%2CFASTA scores: opt: 2994%2C E(): 6.9e-179%2C (76.5%25 identity in 587 aa overlap)%3B and similar in part to other proteins from Mycobacterium leprae e.g. O33082|MLCB628.11 hypothetical 52.0 KDA protein (478 aa)%2C FASTA scores: opt: 481%2C E(): 2.3e-22%2C (30.95%25 identity in 294 aa overlap). Also similar in part to O86637|SC3C3.03c hypothetical 112.1 KDA protein from Streptomyces coelicolor (1083 aa)%2C FASTA scores: opt: 488%2C E(): 1.5e-22%2C (28.95%25 identity in 297 aa overlap). And similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. O06396|Rv0530|MTCY25D10.09 (405 aa)%2CFASTA scores: opt: 625%2C E(): 2.2e-31%2C (34.05%25 identity in 320 aa overlap)%3B O69740|Rv3876|MTV027.11 (666 aa)%2C FASTA scores: opt: 453%2C E(): 1.6e-20%2C (29.2%25 identity in 370 aa overlap)%3B P96217|Rv3860|MTCY01A6.08c (390 aa)%2C FASTA scores: opt: 443%2C E(): 4.7e-20%2C (29.95%25 identity in 354 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2787;product=Conserved hypothetical alanine rich protein;protein_id=CCP45586.1;transl_table=11
AL123456.3	EMBL	gene	3096959	3097645	.	+	.	ID=gene-Rv2788;Name=sirR;gbkey=Gene;gene=sirR;gene_biotype=protein_coding;locus_tag=Rv2788
AL123456.3	EMBL	CDS	3096959	3097645	.	+	0	ID=cds-CCP45587.1;Parent=gene-Rv2788;Dbxref=EnsemblGenomes-Gn:Rv2788,EnsemblGenomes-Tr:CCP45587,GOA:I6Y1Q2,InterPro:IPR000485,InterPro:IPR001367,InterPro:IPR007167,InterPro:IPR008988,InterPro:IPR011991,InterPro:IPR022687,InterPro:IPR022689,UniProtKB/TrEMBL:I6Y1Q2,NCBI_GP:CCP45587.1;Name=CCP45587.1;Note=Rv2788%2C (MTV002.53)%2C len: 228 aa. Probable sirR%2Ctranscriptional repressor%2C highly similar to others e.g. Q9RRF3|DR2539 putative iron dependent repressor from Deinococcus radiodurans (232 aa)%2C FASTA scores: opt: 518%2CE(): 4.5e-26%2C (41.2%25 identity in 221 aa overlap)%3B Q9HRU8|SIRR|VNG0536G from Halobacterium sp. strain NRC-1 (233 aa)%2C FASTA scores: opt: 516%2C E(): 6.1e-26%2C (40.45%25 identity in 220 aa overlap)%3B Q9KIJ2|SLOR regulator SLOR from Streptococcus mutans (217 aa)%2C FASTA scores: opt: 418%2CE(): 1.2e-19%2C (36.15%25 identity in 213 aa overlap)%3B etc. Also some similarity to Q50495|IDER_MYCTU|MTCY05A6.32|IDER|DTXR|Rv2711|MT2784|MTCY 05A6.32 iron-dependent repressor from Mycobacterium tuberculosis (230 aa)%2C FASTA scores: opt: 266%2C E(): 7.1e-10%2C (27.6%25 identity in 221 aa overlap). Contains helix-turn-helix motif at aa 32-53 (Score 1327%2C +3.71 SD). Could belong to the Crp/Fnr family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sirR;locus_tag=Rv2788;product=Probable transcriptional repressor SirR;protein_id=CCP45587.1;transl_table=11
AL123456.3	EMBL	gene	3097706	3098938	.	-	.	ID=gene-Rv2789c;Name=fadE21;gbkey=Gene;gene=fadE21;gene_biotype=protein_coding;locus_tag=Rv2789c
AL123456.3	EMBL	CDS	3097706	3098938	.	-	0	ID=cds-CCP45588.1;Parent=gene-Rv2789c;Dbxref=EnsemblGenomes-Gn:Rv2789c,EnsemblGenomes-Tr:CCP45588,GOA:I6XFA9,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6XFA9,NCBI_GP:CCP45588.1;Name=CCP45588.1;Note=Rv2789c%2C (MTV002.54c)%2C len: 410 aa. Probable fadE21%2Cacyl-CoA dehydrogenase%2C similar to many e.g. P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa)%2CFASTA scores: opt: 689%2C E(): 9.3e-37%2C (35.75%25 identity in 400 aa overlap)%3B Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa)%2C FASTA scores: opt: 679%2C E(): 4.1e-36%2C(37.3%25 identity in 405 aa overlap)%3B Q06319|ACDS_MEGEL from Megasphaera elsdenii (383 aa)%2C FASTA scores: opt: 650%2C E(): 3e-34%2C (37.7%25 identity in 334 aa overlap)%3B etc. Contains acyl-CoA dehydrogenases signature 1 (PS00072). Belongs to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE21;inference=protein motif:PROSITE:PS00072;locus_tag=Rv2789c;product=Probable acyl-CoA dehydrogenase FadE21;protein_id=CCP45588.1;transl_table=11
AL123456.3	EMBL	gene	3098964	3100169	.	-	.	ID=gene-Rv2790c;Name=ltp1;gbkey=Gene;gene=ltp1;gene_biotype=protein_coding;locus_tag=Rv2790c
AL123456.3	EMBL	CDS	3098964	3100169	.	-	0	ID=cds-CCP45589.1;Parent=gene-Rv2790c;Dbxref=EnsemblGenomes-Gn:Rv2790c,EnsemblGenomes-Tr:CCP45589,GOA:O33332,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020613,InterPro:IPR020615,InterPro:IPR020616,InterPro:IPR020617,UniProtKB/TrEMBL:O33332,NCBI_GP:CCP45589.1;Name=CCP45589.1;Note=Rv2790c%2C (MTV002.55c)%2C len: 401 aa. Probable ltp1%2Clipid-transfer protein%2C highly similar to many eukaryotic sterol-carrier proteins/lipid-transfer protein precursors (see Ossendorp %26 Wirtz 1993) e.g. O62742|SCP2 sterol carrier protein X from Oryctolagus cuniculus (Rabbit) (547 aa)%2C FASTA scores: opt: 1710%2C E(): 6e-102%2C (63.7%25 identity in 394 aa overlap)%3B Q9QW19 3-oxoacyl-CoA thiolase homolog (fragment) from Rattus sp. (405 aa)%2C FASTA scores: opt: 1696%2C E(): 3.8e-101%2C (63.2%25 identity in 394 aa overlap)%3B P11915|NLTP_RAT|SCP2|SCP-2 nonspecific lipid-transfer protein precursor from Rattus norvegicus (Rat) (547 aa)%2CFASTA scores: opt: 1696%2C E(): 4.8e-101%2C (63.2%25 identity in 394 aa overlap)%3B P32020|NLTP_MOUSE|SCP2|SCP-2 nonspecific lipid-transfer protein precursor from Mus musculus (Mouse) (547 aa)%2C FASTA scores: opt: 1681%2C E(): 4.3e-100%2C (62.7%25 identity in 394 aa overlap)%3B etc. Contains PS00098 Thiolases acyl-enzyme intermediate signature and PS00737 Thiolases signature 2. Also similar to other M. tuberculosis proteins e.g. O06144|Rv1627c|MTCY01B2.19c (402 aa) (35.8%25 identity in 413 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ltp1;inference=protein motif:PROSITE:PS00737;locus_tag=Rv2790c;product=Probable lipid-transfer protein Ltp1;protein_id=CCP45589.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3100175	3102206	.	+	.	ID=id-AL123456.3:3100175..3102206;Note=IS1602%2C len: 2032 nt. Insertion sequence IS1602.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1602
AL123456.3	EMBL	gene	3100202	3101581	.	-	.	ID=gene-Rv2791c;Name=Rv2791c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2791c
AL123456.3	EMBL	CDS	3100202	3101581	.	-	0	ID=cds-CCP45590.1;Parent=gene-Rv2791c;Dbxref=EnsemblGenomes-Gn:Rv2791c,EnsemblGenomes-Tr:CCP45590,GOA:O33333,InterPro:IPR001959,InterPro:IPR010095,InterPro:IPR021027,UniProtKB/TrEMBL:O33333,NCBI_GP:CCP45590.1;Name=CCP45590.1;Note=Rv2791c%2C (MTV002.56c)%2C len: 459 aa. Probable IS1602 transposase for IS1602 element%2C similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa)%2C FASTA scores: opt: 2718%2C E(): 6.3e-165%2C (86.05%25 identity in 459 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2791c;product=Probable transposase;protein_id=CCP45590.1;transl_table=11
AL123456.3	EMBL	gene	3101581	3102162	.	-	.	ID=gene-Rv2792c;Name=Rv2792c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2792c
AL123456.3	EMBL	CDS	3101581	3102162	.	-	0	ID=cds-CCP45591.1;Parent=gene-Rv2792c;Dbxref=EnsemblGenomes-Gn:Rv2792c,EnsemblGenomes-Tr:CCP45591,GOA:I6YA93,InterPro:IPR006118,InterPro:IPR006119,UniProtKB/TrEMBL:I6YA93,NCBI_GP:CCP45591.1;Name=CCP45591.1;Note=Rv2792c%2C (MTV002.57c)%2C len: 193 aa. Possible IS1602 resolvase%2C highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c possible resolvase (202 aa)%2C FASTA scores: opt: 1040%2C E(): 1.9e-62%2C(85.05%25 identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site and possible helix-turn-helix motif at aa 1-2 (Score 1687%2C +4.93 SD).;gbkey=CDS;inference=protein motif:PROSITE:PS00397;locus_tag=Rv2792c;product=Possible resolvase;protein_id=CCP45591.1;transl_table=11
AL123456.3	EMBL	gene	3102364	3103260	.	-	.	ID=gene-Rv2793c;Name=truB;gbkey=Gene;gene=truB;gene_biotype=protein_coding;locus_tag=Rv2793c
AL123456.3	EMBL	CDS	3102364	3103260	.	-	0	ID=cds-CCP45592.1;Parent=gene-Rv2793c;Dbxref=EnsemblGenomes-Gn:Rv2793c,EnsemblGenomes-Tr:CCP45592,GOA:P9WHP7,InterPro:IPR002501,InterPro:IPR014780,InterPro:IPR015225,InterPro:IPR015947,InterPro:IPR020103,PDB:1SGV,NCBI_GP:CCP45592.1;Name=CCP45592.1;Note=Rv2793c%2C (MTV002.58c)%2C len: 298 aa. Probable truB%2CtRNA pseudouridine synthase%2C equivalent to Q9Z5I4|TRUB_MYCLE|ML1546 or MLCB596.24 tRNA pseudouridine synthase B from Mycobacterium leprae (320 aa)%2C FASTA scores: opt: 1403%2C E(): 2.9e-83%2C (74.05%25 identity in 293 aa overlap). Also highly similar to many e.g. Q9Z528|TRUB_STRCO|SC9F2.07c from Streptomyces coelicolor (301 aa)%2C FASTA scores: opt: 870%2C E(): 7.6e-49%2C (50.7%25 identity in 296 aa overlap)%3B P09171|TRUB_ECOLI|P35|B3166|Z4527|ECS4047 from Escherichia coli strains K12 and O157:H7 (314 aa)%2C FASTA scores: opt: 574%2C E(): 1e-29%2C (42.5%25 identity in 214 aa overlap)%3B Q9PGR1|TRUB_XYLFA|XF0237 from Xylella fastidiosa (302 aa)%2CFASTA scores: opt: 569%2C E(): 2.1e-29%2C (41.05%25 identity in 285 aa overlap)%3B etc. Belongs to the TruB family of pseudouridine synthases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=truB;locus_tag=Rv2793c;product=Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase);protein_id=CCP45592.1;transl_table=11
AL123456.3	EMBL	gene	3103257	3103940	.	-	.	ID=gene-Rv2794c;Name=pptT;gbkey=Gene;gene=pptT;gene_biotype=protein_coding;locus_tag=Rv2794c
AL123456.3	EMBL	CDS	3103257	3103940	.	-	0	ID=cds-CCP45593.1;Parent=gene-Rv2794c;Dbxref=EnsemblGenomes-Gn:Rv2794c,EnsemblGenomes-Tr:CCP45593,GOA:O33336,InterPro:IPR003542,InterPro:IPR008278,PDB:4QJK,UniProtKB/TrEMBL:O33336,NCBI_GP:CCP45593.1;Name=CCP45593.1;Note=Rv2794c%2C (MTV002.59c)%2C len: 227 aa. PptT%2Cphosphopantetheinyl transferase%2C equivalent to Q9Z5I5|ML1547|MLCB596.23 putative iron-chelating complex subunit from Mycobacterium leprae (227 aa)%2C FASTA scores: opt: 1248%2C E(): 9.1e-77%2C (79.75%25 identity in 227 aa overlap). Also highly similar to various proteins e.g. Q9F0Q6|PPTA phosphopantetheinyl transferase from Streptomyces verticillus (246 aa)%2C FASTA scores: opt: 692%2CE(): 2.8e-39%2C (46.65%25 identity in 225 aa overlap)%3B O88029|SC5A7.23 hypothetical 24.5 KDA protein from Streptomyces coelicolor (226 aa)%2C FASTA scores: opt: 679%2CE(): 2e-38%2C (46.9%25 identity in 226 aa overlap)%3B O24813 DNA for L-proline 3-hydroxylase from Streptomyces sp. (208 aa)%2CFASTA scores: opt: 631%2C E(): 3.2e-35%2C (48.1%25 identity in 208 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pptT;locus_tag=Rv2794c;product=Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase);protein_id=CCP45593.1;transl_table=11
AL123456.3	EMBL	gene	3103937	3104911	.	-	.	ID=gene-Rv2795c;Name=Rv2795c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2795c
AL123456.3	EMBL	CDS	3103937	3104911	.	-	0	ID=cds-CCP45594.1;Parent=gene-Rv2795c;Dbxref=EnsemblGenomes-Gn:Rv2795c,EnsemblGenomes-Tr:CCP45594,GOA:I6YEE1,InterPro:IPR004843,InterPro:IPR029052,UniProtKB/TrEMBL:I6YEE1,NCBI_GP:CCP45594.1;Name=CCP45594.1;Note=Rv2795c%2C (MTV002.60c)%2C len: 324 aa. Conserved hypothetical protein%2C equivalent to Q9Z5I6|ML1548|MLCB596.22 hypothetical 37.5 KDA protein from Mycobacterium leprae (321 aa)%2C FASTA scores: opt: 2018%2CE(): 6.3e-128%2C (87.4%25 identity in 318 aa overlap). Also highly similar to O88028|SC5A7.22 hypothetical 33.5 KDA protein from Streptomyces coelicolor (295 aa)%2C FASTA scores: opt: 1202%2C E(): 3.4e-73%2C (57.2%25 identity in 285 aa overlap)%3B and Q9AMH7|SIMX4 SIMX4 protein from Streptomyces antibioticus (293 aa)%2C FASTA scores: opt: 1045%2C E(): 1.2e-62%2C (51.4%25 identity in 286 aa overlap). C-terminus highly similar to Q9F0Q7 hypothetical 9.6 KDA protein (fragment) from Streptomyces verticillus (81 aa)%2C FASTA scores: opt: 395%2C E(): 1.8e-19%2C (68.35%25 identity in 79 aa overlap). Also similar to other proteins e.g. Q9FWV7 hypothetical 45.3 KDA protein from Oryza sativa (Rice) (402 aa)%2C FASTA scores: opt: 294%2C E(): 3.6e-12%2C (26.45%25 identity in 340 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2795c;product=Conserved hypothetical protein;protein_id=CCP45594.1;transl_table=11
AL123456.3	EMBL	gene	3105056	3105619	.	-	.	ID=gene-Rv2796c;Name=lppV;gbkey=Gene;gene=lppV;gene_biotype=protein_coding;locus_tag=Rv2796c
AL123456.3	EMBL	CDS	3105056	3105619	.	-	0	ID=cds-CCP45595.1;Parent=gene-Rv2796c;Dbxref=EnsemblGenomes-Gn:Rv2796c,EnsemblGenomes-Tr:CCP45595,UniProtKB/TrEMBL:P71655,NCBI_GP:CCP45595.1;Name=CCP45595.1;Note=Rv2796c%2C (MTV002.61c%2C MTCY16B7.47)%2C len: 187 aa. Probable lppV%2C conserved lipoprotein%2C similar to others from Mycobacterium tuberculosis e.g. P95009|LPPB|Rv2544|MTCY159.12c probable conserved lipoprotein (220 aa)%2C FASTA scores: opt: 168%2C E(): 0.00066%2C(22.45%25 identity in 196 aa overlap)%3B and P95010|LPPA|RV2543|MTCY159.13c probable conserved lipoprotein (219 aa)%2C FASTA scores: opt: 165%2C E(): 0.001%2C(23.1%25 identity in 199 aa overlap).;gbkey=CDS;gene=lppV;locus_tag=Rv2796c;product=Probable conserved lipoprotein LppV;protein_id=CCP45595.1;transl_table=11
AL123456.3	EMBL	gene	3105619	3107307	.	-	.	ID=gene-Rv2797c;Name=Rv2797c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2797c
AL123456.3	EMBL	CDS	3105619	3107307	.	-	0	ID=cds-CCP45596.1;Parent=gene-Rv2797c;Dbxref=EnsemblGenomes-Gn:Rv2797c,EnsemblGenomes-Tr:CCP45596,InterPro:IPR010427,InterPro:IPR029058,UniProtKB/TrEMBL:P71654,NCBI_GP:CCP45596.1;Name=CCP45596.1;Note=Rv2797c%2C (MTCY16B7.46)%2C len: 562 aa. Conserved hypothetical ala-rich protein. C-terminus highly similar to several mycobacterial proteins e.g. AAK46927|MT2616 hypothetical 28.0 KDA protein from Mycobacterium tuberculosis strain CDC1551 (265 aa)%2C FASTA scores: opt: 535%2C E(): 4.6e-22%2C (42.95%25 identity in 263 aa overlap)%3B P95011|Rv2542|MTCY159.14c hypothetical 42.4 KDA protein from Mycobacterium tuberculosis (403 aa)%2C FASTA scores: opt: 537%2C E(): 5e-22%2C (40.75%25 identity in 292 aa overlap) (similarity in the second half of protein)%3B P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 hypothetical 28.1 KDA protein (266 aa)%2C FASTA scores: opt: 314%2C E(): 5.7e-10%2C (39.0%25 identity in 254 aa overlap)%3B etc. Contains PS00120 Lipases%2C serine active site.;gbkey=CDS;inference=protein motif:PROSITE:PS00120;locus_tag=Rv2797c;product=Conserved hypothetical protein;protein_id=CCP45596.1;transl_table=11
AL123456.3	EMBL	gene	3107311	3107637	.	-	.	ID=gene-Rv2798c;Name=Rv2798c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2798c
AL123456.3	EMBL	CDS	3107311	3107637	.	-	0	ID=cds-CCP45597.1;Parent=gene-Rv2798c;Dbxref=EnsemblGenomes-Gn:Rv2798c,EnsemblGenomes-Tr:CCP45597,InterPro:IPR010310,UniProtKB/TrEMBL:P71653,NCBI_GP:CCP45597.1;Name=CCP45597.1;Note=Rv2798c%2C (MTCY16B7.45)%2C len: 108 aa. Conserved hypothetical ala-rich protein%2C similar to P71545|Y965_MYCTU|Rv0965c|MT0993|MTCY10D7.09 hypothetical 14.5 KDA protein from Mycobacterium tuberculosis (139 aa)%2CFASTA scores: opt: 198%2C E(): 8e-07%2C (38.9%25 identity in 90 aa overlap).;gbkey=CDS;locus_tag=Rv2798c;product=Conserved hypothetical protein;protein_id=CCP45597.1;transl_table=11
AL123456.3	EMBL	gene	3107768	3108397	.	+	.	ID=gene-Rv2799;Name=Rv2799;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2799
AL123456.3	EMBL	CDS	3107768	3108397	.	+	0	ID=cds-CCP45598.1;Parent=gene-Rv2799;Dbxref=EnsemblGenomes-Gn:Rv2799,EnsemblGenomes-Tr:CCP45598,InterPro:IPR024520,UniProtKB/TrEMBL:I6XFB7,NCBI_GP:CCP45598.1;Name=CCP45598.1;Note=Rv2799%2C (MTCY16B7.44c)%2C len: 209 aa. Probable membrane protein. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2799;product=Probable membrane protein;protein_id=CCP45598.1;transl_table=11
AL123456.3	EMBL	gene	3108416	3110065	.	+	.	ID=gene-Rv2800;Name=Rv2800;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2800
AL123456.3	EMBL	CDS	3108416	3110065	.	+	0	ID=cds-CCP45599.1;Parent=gene-Rv2800;Dbxref=EnsemblGenomes-Gn:Rv2800,EnsemblGenomes-Tr:CCP45599,GOA:I6YEE6,InterPro:IPR000383,InterPro:IPR005674,InterPro:IPR008979,InterPro:IPR013736,InterPro:IPR029058,UniProtKB/TrEMBL:I6YEE6,NCBI_GP:CCP45599.1;Name=CCP45599.1;Note=Rv2800%2C (MTCY16B7.43c)%2C len: 549 aa. Possible hydrolase%2C an esterase or an acylase. Similar%2C but longer in N-terminus%2C to esterases or acylases e.g. Q9L9D7|COCE cocaine esterase from Rhodococcus sp. MB1 'Bresler 1999' (574 aa)%2C FASTA scores: opt: 510%2C E(): 3.1e-23%2C (33.6%25 identity in 571 aa overlap)%3B Q9L3U2|STTE putative acylase from Streptomyces rochei (Streptomyces parvullus) (554 aa)%2CFASTA scores: opt: 492%2C E(): 3.7e-22%2C (34.45%25 identity in 569 aa overlap)%3B CAC49652|SMB21424 putative esterase or acylase protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (578 aa)%2C FASTA scores: opt: 405%2CE(): 7.1e-17%2C (34.45%25 identity in 569 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2800;product=Possible hydrolase;protein_id=CCP45599.1;transl_table=11
AL123456.3	EMBL	gene	3110167	3110523	.	-	.	ID=gene-Rv2801c;Name=mazF9;gbkey=Gene;gene=mazF9;gene_biotype=protein_coding;gene_synonym=mt1;locus_tag=Rv2801c
AL123456.3	EMBL	CDS	3110167	3110523	.	-	0	ID=cds-CCP45600.1;Parent=gene-Rv2801c;Dbxref=EnsemblGenomes-Gn:Rv2801c,EnsemblGenomes-Tr:CCP45600,GOA:P71650,InterPro:IPR003477,InterPro:IPR011067,NCBI_GP:CCP45600.1;Name=CCP45600.1;Note=Rv2801c%2C (MTCY16B7.42)%2C len: 118 aa. MazF9%2C toxin%2Cpart of toxin-antitoxin (TA) operon with Rv2801A (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006)%2C highly similar to Q9RWK4|DR0662 conserved hypothetical protein from Deinococcus radiodurans (115 aa)%2C FASTA scores: opt: 306%2CE(): 2e-15%2C (43.95%25 identity in 116 aa overlap)%3B and similar to AAK78474|CAC0494 PEMK family of DNA-binding proteins from Clostridium acetobutylicum (122 aa)%2C FASTA scores: opt: 217%2C E(): 7.3e-09%2C (33.35%25 identity in 117 aa overlap)%3B P96622|YDCE YDCE protein from Bacillus subtilis (116 aa)%2C FASTA scores: opt: 194%2C E(): 3.5e-07%2C (33.35%25 identity in 117 aa overlap)%3B Q9PHH8|XFA0027 plasmid maintenance protein from Xylella fastidiosa (108 aa)%2C FASTA scores: opt: 188%2C E(): 9.1e-07%2C (40.85%25 identity in 115 aa overlap)%3B etc. Also similar to Q10867|YJ91_MYCTU|Rv1991c|MT2046|MTCY39.28 hypothetical 12.3 KDA protein from Mycobacterium tuberculosis (114 aa)%2CFASTA scores: opt: 190%2C E(): 6.8e-07%2C (36.75%25 identity in 117 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mazF9;locus_tag=Rv2801c;product=Toxin MazF9;protein_id=CCP45600.1;transl_table=11
AL123456.3	EMBL	gene	3110507	3110737	.	-	.	ID=gene-Rv2801A;Name=mazE9;gbkey=Gene;gene=mazE9;gene_biotype=protein_coding;locus_tag=Rv2801A
AL123456.3	EMBL	CDS	3110507	3110737	.	-	0	ID=cds-CCP45601.1;Parent=gene-Rv2801A;Dbxref=EnsemblGenomes-Gn:Rv2801A,EnsemblGenomes-Tr:CCP45601,GOA:P0CL61,InterPro:IPR002145,NCBI_GP:CCP45601.1;Name=CCP45601.1;Note=Rv2801A%2C len: 76 aa. Possible mazE9%2C antitoxin%2C part of toxin-antitoxin (TA) operon with Rv2801c (See Pandey and Gerdes%2C 2005%3B Zhu et al.%2C 2006). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=mazE9;locus_tag=Rv2801A;product=Possible antitoxin MazE9;protein_id=CCP45601.1;transl_table=11
AL123456.3	EMBL	gene	3110780	3111823	.	-	.	ID=gene-Rv2802c;Name=Rv2802c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2802c
AL123456.3	EMBL	CDS	3110780	3111823	.	-	0	ID=cds-CCP45602.1;Parent=gene-Rv2802c;Dbxref=EnsemblGenomes-Gn:Rv2802c,EnsemblGenomes-Tr:CCP45602,InterPro:IPR018744,UniProtKB/TrEMBL:P71649,NCBI_GP:CCP45602.1;Name=CCP45602.1;Note=Rv2802c%2C (MTCY16B7.41)%2C len: 347 aa. Hypothetical unknown arg-%2C ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti) (104 aa)%2C FASTA scores: opt: 138%2C E(): 0.12%2C (37.35%25 identity in 91 aa overlap)%3B and CAC47718|SMC03294 from Rhizobium meliloti (Sinorhizobium meliloti) (114 aa)%2C FASTA scores: opt: 128%2C E(): 0.53%2C (31.4%25 identity in 86 aa overlap). Equivalent to AAK47191 from Mycobacterium tuberculosis strain CDC1551 (357 aa) but shorter 10 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2802c;product=Hypothetical arginine and alanine rich protein;protein_id=CCP45602.1;transl_table=11
AL123456.3	EMBL	gene	3111822	3112289	.	+	.	ID=gene-Rv2803;Name=Rv2803;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2803
AL123456.3	EMBL	CDS	3111822	3112289	.	+	0	ID=cds-CCP45603.1;Parent=gene-Rv2803;Dbxref=EnsemblGenomes-Gn:Rv2803,EnsemblGenomes-Tr:CCP45603,GOA:I6XFC2,InterPro:IPR010985,InterPro:IPR014795,InterPro:IPR016547,UniProtKB/TrEMBL:I6XFC2,NCBI_GP:CCP45603.1;Name=CCP45603.1;Note=Rv2803%2C len: 155 aa. Conserved hypothetical protein%2Csimilar to hypothetical proteins from other organisms%2C and with some similarity to C-terminal part of Rv0918|Z95210_12 hypothetical protein from Mycobacterium tuberculosis (158 aa)%2C FASTA scores: opt: 204%2C E(): 9e-07%2C (42.35%25 identity in 85 aa overlap). Replaces original 2803c on other strand. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2803;product=Conserved hypothetical protein;protein_id=CCP45603.1;transl_table=11
AL123456.3	EMBL	gene	3112465	3113094	.	-	.	ID=gene-Rv2804c;Name=Rv2804c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2804c
AL123456.3	EMBL	CDS	3112465	3113094	.	-	0	ID=cds-CCP45604.1;Parent=gene-Rv2804c;Dbxref=EnsemblGenomes-Gn:Rv2804c,EnsemblGenomes-Tr:CCP45604,UniProtKB/TrEMBL:I6YEE9,NCBI_GP:CCP45604.1;Name=CCP45604.1;Note=Rv2804c%2C (MTCY16B7.39)%2C len: 209 aa. Hypothetical unknown protein%2C overlaps neighbouring orf Rv2805|MTCY16B7.38c. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2804c;product=Hypothetical protein;protein_id=CCP45604.1;transl_table=11
AL123456.3	EMBL	gene	3112867	3113271	.	+	.	ID=gene-Rv2805;Name=Rv2805;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2805
AL123456.3	EMBL	CDS	3112867	3113271	.	+	0	ID=cds-CCP45605.1;Parent=gene-Rv2805;Dbxref=EnsemblGenomes-Gn:Rv2805,EnsemblGenomes-Tr:CCP45605,UniProtKB/TrEMBL:P71646,NCBI_GP:CCP45605.1;Name=CCP45605.1;Note=Rv2805%2C (MTCY16B7.38c)%2C len: 134 aa. Conserved hypothetical protein%2C highly similar to N-terminal region of downstream ORF P71644|Rv2807|MTCY16B7.36c conserved hypothetical protein from Mycobacterium tuberculosis (384 aa)%2C FASTA scores: opt: 525%2C E(): 6.4e-29%2C (78.2%25 identity in 101 aa overlap). Also highly similar to N-terminus of other proteins: Q9KK74 hypothetical 47.4 KDA protein from Brevibacterium linens (418 aa)%2C FASTA scores: opt: 480%2CE(): 8.8e-26%2C (64.15%25 identity in 106 aa overlap)%3B AAK40065 Rv3128c-like protein from Mycobacterium celatum (423 aa)%2CFASTA scores: opt: 218%2C E(): 1.2e-07%2C (46.05%25 identity in 89 aa overlap)%3B Q981U5|MLR9230 from Rhizobium loti (Mesorhizobium loti) (504 aa)%2C FASTA scores: opt: 131%2C E(): 0.15%2C (29.4%25 identity in 126 aa overlap). Overlaps neighbouring ORF Rv2804c|MTCY16B7.39. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2805;product=Conserved hypothetical protein;protein_id=CCP45605.1;transl_table=11
AL123456.3	EMBL	gene	3113268	3113459	.	+	.	ID=gene-Rv2806;Name=Rv2806;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2806
AL123456.3	EMBL	CDS	3113268	3113459	.	+	0	ID=cds-CCP45606.1;Parent=gene-Rv2806;Dbxref=EnsemblGenomes-Gn:Rv2806,EnsemblGenomes-Tr:CCP45606,UniProtKB/TrEMBL:I6YAA5,NCBI_GP:CCP45606.1;Name=CCP45606.1;Note=Rv2806%2C (MTCY16B7.37c)%2C len: 63 aa. Possible membrane protein%2C sharing no homology. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2806;product=Possible membrane protein;protein_id=CCP45606.1;transl_table=11
AL123456.3	EMBL	gene	3113658	3114812	.	+	.	ID=gene-Rv2807;Name=Rv2807;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2807
AL123456.3	EMBL	CDS	3113658	3114812	.	+	0	ID=cds-CCP45607.1;Parent=gene-Rv2807;Dbxref=EnsemblGenomes-Gn:Rv2807,EnsemblGenomes-Tr:CCP45607,GOA:P71644,InterPro:IPR001584,InterPro:IPR012337,UniProtKB/TrEMBL:P71644,NCBI_GP:CCP45607.1;Name=CCP45607.1;Note=Rv2807%2C (MTCY16B7.36c)%2C len: 384 aa. Conserved hypothetical protein%2C highly similar%2C but shorter 35 aa%2C to Q9KK74 hypothetical 47.4 KDA protein from Brevibacterium linens (418 aa)%2C FASTA scores: opt: 1865%2C E(): 9.4e-116%2C(69.75%25 identity in 380 aa overlap)%3B and with similarity with other hypothetical proteins or transposases e.g. Q981U5|MLR9230 protein from Rhizobium loti (Mesorhizobium loti) (504 aa)%2C FASTA scores: opt: 636%2C%2C (36.05%25 identity in 377 aa overlap)%3B CAC47689 putative transposase for insertion sequence ISRM18 from Rhizobium meliloti (Sinorhizobium meliloti) (507 aa)%2C FASTA scores: opt: 553%2CE(): 6.6e-29%2C (33.5%25 identity in 370 aa overlap)%3B etc. Also similar to Rv3128c|MTCY164.38c (336 aa) (47.2%25 identity in 339 aa overlap)%3B and high similarity at N-terminal region with Rv2805|MTCY16B7.38c (79.2%25 identity in 101 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2807;product=Conserved hypothetical protein;protein_id=CCP45607.1;transl_table=11
AL123456.3	EMBL	gene	3115046	3115303	.	+	.	ID=gene-Rv2808;Name=Rv2808;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2808
AL123456.3	EMBL	CDS	3115046	3115303	.	+	0	ID=cds-CCP45608.1;Parent=gene-Rv2808;Dbxref=EnsemblGenomes-Gn:Rv2808,EnsemblGenomes-Tr:CCP45608,UniProtKB/TrEMBL:P71643,NCBI_GP:CCP45608.1;Name=CCP45608.1;Note=Rv2808%2C (MTCY16B7.35c)%2C len: 85 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2808;product=Hypothetical protein;protein_id=CCP45608.1;transl_table=11
AL123456.3	EMBL	gene	3115408	3115719	.	+	.	ID=gene-Rv2809;Name=Rv2809;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2809
AL123456.3	EMBL	CDS	3115408	3115719	.	+	0	ID=cds-CCP45609.1;Parent=gene-Rv2809;Dbxref=EnsemblGenomes-Gn:Rv2809,EnsemblGenomes-Tr:CCP45609,UniProtKB/TrEMBL:I6YEF3,NCBI_GP:CCP45609.1;Name=CCP45609.1;Note=Rv2809%2C (MTCY16B7.34c)%2C len: 103 aa (questionable ORF). Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2809;product=Hypothetical protein;protein_id=CCP45609.1;transl_table=11
AL123456.3	EMBL	gene	3115741	3116142	.	-	.	ID=gene-Rv2810c;Name=Rv2810c;end_range=3116142,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2810c;partial=true
AL123456.3	EMBL	CDS	3115741	3116142	.	-	0	ID=cds-CCP45610.1;Parent=gene-Rv2810c;Dbxref=EnsemblGenomes-Gn:Rv2810c,EnsemblGenomes-Tr:CCP45610,GOA:P71641,InterPro:IPR002560,UniProtKB/TrEMBL:P71641,NCBI_GP:CCP45610.1;Name=CCP45610.1;Note=Rv2810c%2C (MTCY16B7.33)%2C len: 133 aa. Probable transposase for IS1555%2C similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA transposase from Arthrobacter sp. TM1 (435 aa)%2C FASTA scores: opt: 294%2C E(): 1.8e-13%2C (55.1%25 identity in 98 aa overlap)%3B Q50440|TNPA insertion element TNPR and TNPA gene from Mycobacterium smegmatis (413 aa)%2C FASTA scores: opt: 274%2C E(): 4.7e-12%2C (56.25%25 identity in 96 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;end_range=3116142,.;gbkey=CDS;locus_tag=Rv2810c;partial=true;product=Probable transposase;protein_id=CCP45610.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3115744	3116142	.	-	.	ID=id-Rv2810c;Note=IS1555'%2C len: 399 nt. Probable defective Insertion sequence element%2C IS1555. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1555'
AL123456.3	EMBL	gene	3116139	3116747	.	+	.	ID=gene-Rv2811;Name=Rv2811;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2811
AL123456.3	EMBL	CDS	3116139	3116747	.	+	0	ID=cds-CCP45611.1;Parent=gene-Rv2811;Dbxref=EnsemblGenomes-Gn:Rv2811,EnsemblGenomes-Tr:CCP45611,UniProtKB/TrEMBL:P71640,NCBI_GP:CCP45611.1;Name=CCP45611.1;Note=Rv2811%2C (MTCY16B7.32c)%2C len: 202 aa. Conserved hypothetical protein. C-terminus equivalent to C-terminus of AAK47198|MT2878 hypothetical 17.7 KDA protein Mycobacterium tuberculosis strain CDC1551 (178 aa)%2C FASTA scores: opt: 609%2C E(): 1.5e-32%2C (61.0%25 identity in 182 aa overlap)%3B and C-terminus highly similar to P72038|Rv3771c|MTCY13D12.05c hypothetical 11.3 KDA protein from Mycobacterium tuberculosis (108 aa)%2C FASTA scores: opt: 465%2C E(): 2.8e-23%2C (73.6%25 identity in 106 aa overlap). Also some similarity with P71962|Rv2665|MTCY441.34 hypothetical 10.5 KDA protein from Mycobacterium tuberculosis (93 aa)%2C FASTA scores: opt: 153%2C E(): 0.0057%2C(39.05%25 identity in 64 aa overlap)%3B and Q9A6W6|CC1966 hypothetical protein CC1966 from Caulobacter crescentus (189 aa)%2C FASTA scores: opt: 115%2C E(): 2.6%2C (39.4%25 identity in 104 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2811;product=Conserved hypothetical protein;protein_id=CCP45611.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3116817	3118225	.	+	.	ID=id-AL123456.3:3116817..3118225;Note=IS1604%2C len: 1409 nt. Insertion sequence IS1604. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1604
AL123456.3	EMBL	gene	3116818	3118227	.	+	.	ID=gene-Rv2812;Name=Rv2812;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2812
AL123456.3	EMBL	CDS	3116818	3118227	.	+	0	ID=cds-CCP45612.1;Parent=gene-Rv2812;Dbxref=EnsemblGenomes-Gn:Rv2812,EnsemblGenomes-Tr:CCP45612,GOA:P71639,InterPro:IPR001584,InterPro:IPR009057,InterPro:IPR012337,InterPro:IPR015378,UniProtKB/TrEMBL:P71639,NCBI_GP:CCP45612.1;Name=CCP45612.1;Note=Rv2812%2C (MTCY16B7.31c)%2C len: 469 aa. Probable transposase for IS1604%2C similar to putative transposases and hypothetical proteins e.g. Q9EZM2|putative transposase from Mycobacterium paratuberculosis (395 aa)%2C FASTA scores: opt: 329%2C E(): 3e-13%2C (27.05%25 identity in 362 aa overlap)%3B CAC46499 putative transposase protein from Rhizobium meliloti (Sinorhizobium meliloti) (390 aa)%2C FASTA scores: opt: 327%2C E(): 3.9e-13%2C (30.5%25 identity in 367 aa overlap)%3B etc. Contains possible helix-turn-helix motif at aa 50-71 (Score 1140%2C +3.07 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2812;product=Probable transposase;protein_id=CCP45612.1;transl_table=11
AL123456.3	EMBL	gene	3118224	3119036	.	+	.	ID=gene-Rv2813;Name=Rv2813;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2813
AL123456.3	EMBL	CDS	3118224	3119036	.	+	0	ID=cds-CCP45613.1;Parent=gene-Rv2813;Dbxref=EnsemblGenomes-Gn:Rv2813,EnsemblGenomes-Tr:CCP45613,InterPro:IPR027417,UniProtKB/TrEMBL:I6XFD1,NCBI_GP:CCP45613.1;Name=CCP45613.1;Note=Rv2813%2C (MTCY16B7.30c)%2C len: 270 aa. Conserved hypothetical protein%2C similar to various proteins (notably secreted proteins) e.g. Q9ZFL2 hypothetical 30.4 KDA protein from Bacillus stearothermophilus (266 aa)%2C FASTA scores: opt: 518%2C E(): 1.4e-26%2C (33.85%25 identity in 266 aa overlap)%3B P45754|GSPA_AERHY|EXEA general secretion pathway protein from Aeromonas hydrophila (547 aa)%2C FASTA scores: opt: 386%2C E(): 1.1e-17%2C (32.05%25 identity in 265 aa overlap)%3B Q9KPC7|VC2445 general secretion pathway protein A from Vibrio cholerae (529 aa)%2C FASTA scores: opt: 366%2C E(): 2.2e-16%2C (31.1%25 identity in 270 aa overlap)%3B Q56674|VC0403 mannose-sensitive hemagglutinin D from Vibrio cholerae (281 aa)%2C FASTA scores: opt: 317%2C E(): 2.1e-13%2C (27.85%25 identity in 262 aa overlap)%3B etc. Also highly similar to AAK40072 Rv2813-like protein from Mycobacterium celatum (270 aa)%2CFASTA scores: opt: 1628%2C E(): 2.8e-99%2C (90.75%25 identity in 270 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2813;product=Conserved hypothetical protein;protein_id=CCP45613.1;transl_table=11
AL123456.3	EMBL	repeat_region	3119185	3123576	.	-	.	ID=id-AL123456.3:3119185..3123576;Note=4392 bp direct repeat region. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119185	3119220	.	-	.	ID=id-AL123456.3:3119185..3119220;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119259	3119294	.	-	.	ID=id-AL123456.3:3119259..3119294;Note=36 bp direct repeat%2C 35 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119335	3119370	.	-	.	ID=id-AL123456.3:3119335..3119370;Note=36 bp direct repeat%2C 35 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119411	3119446	.	-	.	ID=id-AL123456.3:3119411..3119446;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119484	3119519	.	-	.	ID=id-AL123456.3:3119484..3119519;Note=36 bp direct repeat%2C 35 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119556	3119591	.	-	.	ID=id-AL123456.3:3119556..3119591;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119627	3119662	.	-	.	ID=id-AL123456.3:3119627..3119662;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119701	3119736	.	-	.	ID=id-AL123456.3:3119701..3119736;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119777	3119812	.	-	.	ID=id-AL123456.3:3119777..3119812;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119848	3119883	.	-	.	ID=id-AL123456.3:3119848..3119883;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119921	3119956	.	-	.	ID=id-AL123456.3:3119921..3119956;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3119995	3120030	.	-	.	ID=id-AL123456.3:3119995..3120030;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3120068	3120103	.	-	.	ID=id-AL123456.3:3120068..3120103;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3120141	3120176	.	-	.	ID=id-AL123456.3:3120141..3120176;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3120213	3120248	.	-	.	ID=id-AL123456.3:3120213..3120248;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3120285	3120320	.	-	.	ID=id-AL123456.3:3120285..3120320;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3120359	3120394	.	-	.	ID=id-AL123456.3:3120359..3120394;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3120433	3120468	.	-	.	ID=id-AL123456.3:3120433..3120468;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3120504	3120523	.	-	.	ID=id-AL123456.3:3120504..3120523;Note=20 bp partial direct repeat%2C CCCCGAGAGGGGACGGAAAC%2Cof sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	3120523	3121897	.	-	.	ID=id-AL123456.3:3120523..3121897;Note=IS6110-11%2C len: 1375 nt. Insertion sequence IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-11
AL123456.3	EMBL	gene	3120566	3121552	.	-	.	ID=gene-Rv2814c;Name=Rv2814c;end_range=3121552,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2814c;partial=true
AL123456.3	EMBL	CDS	3120566	3121552	.	-	0	ID=cds-CCP45614.1;Parent=gene-Rv2814c;Dbxref=EnsemblGenomes-Gn:Rv2814c,EnsemblGenomes-Tr:CCP45614,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP45614.1;Name=CCP45614.1;Note=Rv2814c%2C (MTCY16B7.29)%2C len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2814c and Rv2815c%2C the sequence UUUUAAAG (directly upstream of Rv2814c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 16 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;end_range=3121552,.;gbkey=CDS;locus_tag=Rv2814c;partial=true;product=Probable transposase;protein_id=CCP45614.1;transl_table=11
AL123456.3	EMBL	gene	3121501	3121827	.	-	.	ID=gene-Rv2815c;Name=Rv2815c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2815c
AL123456.3	EMBL	CDS	3121501	3121827	.	-	0	ID=cds-CCP45615.1;Parent=gene-Rv2815c;Dbxref=EnsemblGenomes-Gn:Rv2815c,EnsemblGenomes-Tr:CCP45615,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP45615.1;Name=CCP45615.1;Note=Rv2815c%2C (MTCY16B7.28)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv2814c and Rv2815c%2C the sequence UUUUAAAG (directly upstream of Rv2814c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2815c;product=Probable transposase;protein_id=CCP45615.1;transl_table=11
AL123456.3	EMBL	repeat_region	3121882	3121897	.	-	.	ID=id-AL123456.3:3121882..3121897;Note=16 bp partial direct repeat%2C GTCGTCAGACCCAAAA%2C of sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3121938	3121973	.	-	.	ID=id-AL123456.3:3121938..3121973;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122013	3122048	.	-	.	ID=id-AL123456.3:3122013..3122048;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122086	3122121	.	-	.	ID=id-AL123456.3:3122086..3122121;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122158	3122193	.	-	.	ID=id-AL123456.3:3122158..3122193;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122230	3122265	.	-	.	ID=id-AL123456.3:3122230..3122265;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122303	3122338	.	-	.	ID=id-AL123456.3:3122303..3122338;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122375	3122410	.	-	.	ID=id-AL123456.3:3122375..3122410;Note=36 bp direct repeat%2C 32 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122436	3122471	.	-	.	ID=id-AL123456.3:3122436..3122471;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122513	3122548	.	-	.	ID=id-AL123456.3:3122513..3122548;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122585	3122620	.	-	.	ID=id-AL123456.3:3122585..3122620;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122661	3122696	.	-	.	ID=id-AL123456.3:3122661..3122696;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122738	3122773	.	-	.	ID=id-AL123456.3:3122738..3122773;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122811	3122846	.	-	.	ID=id-AL123456.3:3122811..3122846;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122882	3122917	.	-	.	ID=id-AL123456.3:3122882..3122917;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3122955	3122990	.	-	.	ID=id-AL123456.3:3122955..3122990;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123029	3123064	.	-	.	ID=id-AL123456.3:3123029..3123064;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123102	3123137	.	-	.	ID=id-AL123456.3:3123102..3123137;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123173	3123208	.	-	.	ID=id-AL123456.3:3123173..3123208;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123248	3123283	.	-	.	ID=id-AL123456.3:3123248..3123283;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123318	3123353	.	-	.	ID=id-AL123456.3:3123318..3123353;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123390	3123425	.	-	.	ID=id-AL123456.3:3123390..3123425;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123467	3123502	.	-	.	ID=id-AL123456.3:3123467..3123502;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3123541	3123576	.	-	.	ID=id-AL123456.3:3123541..3123576;Note=36 bp direct repeat%2C 36 out of 36 bp identical to sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3123625	3123966	.	-	.	ID=gene-Rv2816c;Name=Rv2816c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2816c
AL123456.3	EMBL	CDS	3123625	3123966	.	-	0	ID=cds-CCP45616.1;Parent=gene-Rv2816c;Dbxref=EnsemblGenomes-Gn:Rv2816c,EnsemblGenomes-Tr:CCP45616,GOA:P9WPJ3,InterPro:IPR000640,InterPro:IPR019199,InterPro:IPR021127,NCBI_GP:CCP45616.1;Name=CCP45616.1;Note=Rv2816c%2C (MTCY16B7.27)%2C len: 113 aa. Conserved hypothetical protein%2C highly similar in part to N-terminus of several proteins e.g. O28403|AF1876 conserved hypothetical protein from Archaeoglobus fulgidus (94 aa)%2CFASTA scores: opt: 137%2C E(): 0.0022%2C (47.55%25 identity in 61 aa overlap)%3B Q97Y85|SSO8090 hypothetical protein from Sulfolobus solfataricus (88 aa)%2C FASTA scores: opt: 124%2CE(): 0.02%2C (37.3%25 identity in 59 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2816c;product=Conserved hypothetical protein;protein_id=CCP45616.1;transl_table=11
AL123456.3	EMBL	gene	3123967	3124983	.	-	.	ID=gene-Rv2817c;Name=Rv2817c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2817c
AL123456.3	EMBL	CDS	3123967	3124983	.	-	0	ID=cds-CCP45617.1;Parent=gene-Rv2817c;Dbxref=EnsemblGenomes-Gn:Rv2817c,EnsemblGenomes-Tr:CCP45617,GOA:P9WPJ5,InterPro:IPR002729,NCBI_GP:CCP45617.1;Name=CCP45617.1;Note=Rv2817c%2C (MTCY16B7.26)%2C len: 338 aa. Conserved hypothetical protein%2C showing similarity with O30236|AF2435 conserved hypothetical protein from Archaeoglobus fulgidus (322 aa)%2C FASTA scores: opt: 397%2C E(): 2.4e-19%2C (28.2%25 identity in 298 aa overlap)%3B Q9KFX9|BH0341 hypothetical protein from Bacillus halodurans (343 aa)%2C FASTA scores: opt: 337%2C E(): 2.8e-15%2C (27.35%25 identity in 300 aa overlap)%3B Q9X2B7|TM1797 conserved hypothetical protein from Thermotoga maritima (319 aa)%2C FASTA scores: opt: 321%2C E(): 3.3e-14%2C (26.5%25 identity in 268 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2817c;product=Conserved hypothetical protein;protein_id=CCP45617.1;transl_table=11
AL123456.3	EMBL	gene	3124996	3126144	.	-	.	ID=gene-Rv2818c;Name=Rv2818c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2818c
AL123456.3	EMBL	CDS	3124996	3126144	.	-	0	ID=cds-CCP45618.1;Parent=gene-Rv2818c;Dbxref=EnsemblGenomes-Gn:Rv2818c,EnsemblGenomes-Tr:CCP45618,GOA:P71635,InterPro:IPR013489,NCBI_GP:CCP45618.1;Name=CCP45618.1;Note=Rv2818c%2C (MTCY16B7.25)%2C len: 382 aa. Hypothetical unknown protein%2C equivalent to AAK47210 from Mycobacterium tuberculosis strain CDC1551 (430 aa) but shorter 48 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2818c;product=Hypothetical protein;protein_id=CCP45618.1;transl_table=11
AL123456.3	EMBL	gene	3126240	3127367	.	-	.	ID=gene-Rv2819c;Name=Rv2819c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2819c
AL123456.3	EMBL	CDS	3126240	3127367	.	-	0	ID=cds-CCP45619.1;Parent=gene-Rv2819c;Dbxref=EnsemblGenomes-Gn:Rv2819c,EnsemblGenomes-Tr:CCP45619,GOA:P9WJF5,InterPro:IPR005537,InterPro:IPR010173,NCBI_GP:CCP45619.1;Name=CCP45619.1;Note=Rv2819c%2C (MTCY16B7.23)%2C len: 375 aa. Hypothetical unknown protein (see citations below). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2819c;product=Hypothetical protein;protein_id=CCP45619.1;transl_table=11
AL123456.3	EMBL	gene	3127364	3128272	.	-	.	ID=gene-Rv2820c;Name=Rv2820c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2820c
AL123456.3	EMBL	CDS	3127364	3128272	.	-	0	ID=cds-CCP45620.1;Parent=gene-Rv2820c;Dbxref=EnsemblGenomes-Gn:Rv2820c,EnsemblGenomes-Tr:CCP45620,GOA:P9WJF7,InterPro:IPR005510,NCBI_GP:CCP45620.1;Name=CCP45620.1;Note=Rv2820c%2C (MTCY16B7.22)%2C len: 302 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2820c;product=Hypothetical protein;protein_id=CCP45620.1;transl_table=11
AL123456.3	EMBL	gene	3128253	3128963	.	-	.	ID=gene-Rv2821c;Name=Rv2821c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2821c
AL123456.3	EMBL	CDS	3128253	3128963	.	-	0	ID=cds-CCP45621.1;Parent=gene-Rv2821c;Dbxref=EnsemblGenomes-Gn:Rv2821c,EnsemblGenomes-Tr:CCP45621,GOA:P9WJF9,InterPro:IPR005537,InterPro:IPR013412,NCBI_GP:CCP45621.1;Name=CCP45621.1;Note=Rv2821c%2C (MTCY16B7.21)%2C len: 236 aa. Conserved hypothetical protein%2C similar to several hypothetical proteins e.g. Q9X2C9|TM1809 conserved hypothetical protein from Thermotoga maritima (247 aa)%2C FASTA scores: opt: 318%2CE(): 8.2e-15%2C (39.45%25 identity in 213 aa overlap)%3B O27152|MTH1080 conserved hypothetical protein from Methanothermobacter thermautotrophicus (245 aa)%2C FASTA scores: opt: 294%2C E(): 3.9e-13%2C (34.8%25 identity in 224 aa overlap)%3B BAB59251|TVG0114661 hypothetical protein from Thermoplasma volcanium (229 aa)%2C FASTA scores: opt: 252%2CE(): 3.3e-10%2C (33.8%25 identity in 225 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2821c;product=Conserved hypothetical protein;protein_id=CCP45621.1;transl_table=11
AL123456.3	EMBL	gene	3128973	3129347	.	-	.	ID=gene-Rv2822c;Name=Rv2822c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2822c
AL123456.3	EMBL	CDS	3128973	3129347	.	-	0	ID=cds-CCP45622.1;Parent=gene-Rv2822c;Dbxref=EnsemblGenomes-Gn:Rv2822c,EnsemblGenomes-Tr:CCP45622,GOA:P9WJG1,InterPro:IPR010149,NCBI_GP:CCP45622.1;Name=CCP45622.1;Note=Rv2822c%2C (MTCY16B7.20)%2C len: 124 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2822c;product=Hypothetical protein;protein_id=CCP45622.1;transl_table=11
AL123456.3	EMBL	gene	3129344	3131773	.	-	.	ID=gene-Rv2823c;Name=Rv2823c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2823c
AL123456.3	EMBL	CDS	3129344	3131773	.	-	0	ID=cds-CCP45623.1;Parent=gene-Rv2823c;Dbxref=EnsemblGenomes-Gn:Rv2823c,EnsemblGenomes-Tr:CCP45623,GOA:P71629,InterPro:IPR000160,InterPro:IPR013408,NCBI_GP:CCP45623.1;Name=CCP45623.1;Note=Rv2823c%2C (MTCY16B7.19)%2C len: 809 aa. Conserved protein%2C similar in part to others e.g. Q9X2D1|TM1811Thermotoga maritima (717 aa)%2C FASTA scores: opt: 401%2C E(): 3.6e-18%2C (27.15%25 identity in 773 aa overlap)%3B O27154|MTH1082 conserved hypothetical protein from Methanothermobacter thermautotrophicus (822 aa)%2C FASTA scores: opt: 306%2C E(): 6e-12%2C (25.55%25 identity in 872 aa overlap)%3B Q59066|MJ1672 hypothetical protein from Methanococcus jannaschii (800 aa)%2C FASTA scores: opt: 302%2CE(): 1.1e-11%2C (24.9%25 identity in 812 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2823c;product=Conserved protein;protein_id=CCP45623.1;transl_table=11
AL123456.3	EMBL	gene	3131770	3132714	.	-	.	ID=gene-Rv2824c;Name=Rv2824c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2824c
AL123456.3	EMBL	CDS	3131770	3132714	.	-	0	ID=cds-CCP45624.1;Parent=gene-Rv2824c;Dbxref=EnsemblGenomes-Gn:Rv2824c,EnsemblGenomes-Tr:CCP45624,GOA:P9WPJ1,InterPro:IPR010156,InterPro:IPR019267,NCBI_GP:CCP45624.1;Name=CCP45624.1;Note=Rv2824c%2C (MTCY16B7.18)%2C len: 314 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2824c;product=Hypothetical protein;protein_id=CCP45624.1;transl_table=11
AL123456.3	EMBL	gene	3132892	3133539	.	-	.	ID=gene-Rv2825c;Name=Rv2825c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2825c
AL123456.3	EMBL	CDS	3132892	3133539	.	-	0	ID=cds-CCP45625.1;Parent=gene-Rv2825c;Dbxref=EnsemblGenomes-Gn:Rv2825c,EnsemblGenomes-Tr:CCP45625,InterPro:IPR008307,InterPro:IPR014923,UniProtKB/TrEMBL:P71627,NCBI_GP:CCP45625.1;Name=CCP45625.1;Note=Rv2825c%2C (MTCY16B7.17)%2C len: 215 aa. Conserved hypothetical protein%2C similar to Q9RY53|DR0097 conserved hypothetical protein from Deinococcus radiodurans (189 aa)%2CFASTA scores: opt: 261%2C E(): 8e-11%2C (33.5%25 identity in 176 aa overlap)%3B and shows some similarity with N-terminus of O27278|MTH1210 MRR restriction system related protein from Methanothermobacter thermautotrophicus (340 aa)%2C FASTA scores: opt: 133%2C E(): 0.091%2C (28.55%25 identity in 112 aa overlap). Equivalent to AAK47217 from Mycobacterium tuberculosis strain CDC1551 (246 aa) but shorter 31 aa%3B and equivalent to upstream ORF P71624|Rv2828c|MTCY16B7.14 from Mycobacterium tuberculosis strain H37Rv (alias AAK47221 from strain CDC1551) (181 aa)%2C FASTA scores: opt: 1169%2CE(): 8.5e-74%2C (98.35%25 identity in 181 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2825c;product=Conserved hypothetical protein;protein_id=CCP45625.1;transl_table=11
AL123456.3	EMBL	gene	3133709	3134593	.	-	.	ID=gene-Rv2826c;Name=Rv2826c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2826c
AL123456.3	EMBL	CDS	3133709	3134593	.	-	0	ID=cds-CCP45626.1;Parent=gene-Rv2826c;Dbxref=EnsemblGenomes-Gn:Rv2826c,EnsemblGenomes-Tr:CCP45626,GOA:P71626,InterPro:IPR014942,UniProtKB/TrEMBL:P71626,NCBI_GP:CCP45626.1;Name=CCP45626.1;Note=Rv2826c%2C (MTCY16B7.16)%2C len: 294 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2826c;product=Hypothetical protein;protein_id=CCP45626.1;transl_table=11
AL123456.3	EMBL	gene	3134596	3135483	.	-	.	ID=gene-Rv2827c;Name=Rv2827c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2827c
AL123456.3	EMBL	CDS	3134596	3135483	.	-	0	ID=cds-CCP45627.1;Parent=gene-Rv2827c;Dbxref=EnsemblGenomes-Gn:Rv2827c,EnsemblGenomes-Tr:CCP45627,GOA:P71625,InterPro:IPR018547,UniProtKB/TrEMBL:P71625,NCBI_GP:CCP45627.1;Name=CCP45627.1;Note=Rv2827c%2C (MTCY16B7.15)%2C len: 295 aa. Hypothetical unknown protein%2C equivalent to AAK47219 from Mycobacterium tuberculosis strain CDC1551 (315 aa) but shorter 20 aa.;gbkey=CDS;locus_tag=Rv2827c;product=Hypothetical protein;protein_id=CCP45627.1;transl_table=11
AL123456.3	EMBL	gene	3135788	3136333	.	-	.	ID=gene-Rv2828c;Name=Rv2828c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2828c
AL123456.3	EMBL	CDS	3135788	3136333	.	-	0	ID=cds-CCP45628.1;Parent=gene-Rv2828c;Dbxref=EnsemblGenomes-Gn:Rv2828c,EnsemblGenomes-Tr:CCP45628,InterPro:IPR008307,InterPro:IPR014923,UniProtKB/TrEMBL:I6X5G8,NCBI_GP:CCP45628.1;Name=CCP45628.1;Note=Rv2828c%2C (MTCY16B7.14)%2C len: 181 aa. Conserved hypothetical protein%2C similar to Q9RY53|DR0097 conserved hypothetical protein from Deinococcus radiodurans (189 aa)%2CFASTA scores: opt: 267%2C E(): 1.9e-11%2C (34.1%25 identity in 176 aa overlap)%3B and shows some similarity with N-terminus of O27278|MTH1210 MRR restriction system related protein from Methanothermobacter thermautotrophicus (340 aa)%2C FASTA scores: opt: 133%2C E(): 0.07%2C (28.55%25 identity in 112 aa overlap). Also equivalent to downstream ORF P71627|Rv2825c|MTCY16B7.17 from Mycobacterium tuberculosis strain H37Rv (alias AAK47217 from strain CDC1551%2C 246 aa) (215 aa)%2C FASTA scores: opt: 1173%2C E(): 8.3e-75%2C (98.9%25 identity in 181 aa overlap).;gbkey=CDS;locus_tag=Rv2828c;product=Conserved hypothetical protein;protein_id=CCP45628.1;transl_table=11
AL123456.3	EMBL	gene	3136330	3136599	.	-	.	ID=gene-Rv2828A;Name=Rv2828A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2828A
AL123456.3	EMBL	CDS	3136330	3136599	.	-	0	ID=cds-CCP45629.1;Parent=gene-Rv2828A;Dbxref=EnsemblGenomes-Gn:Rv2828A,EnsemblGenomes-Tr:CCP45629,InterPro:IPR018735,UniProtKB/TrEMBL:I6YAC9,NCBI_GP:CCP45629.1;Name=CCP45629.1;Note=Rv2828A%2C len: 89 aa. Conserved hypothetical protein%2Cpresent in many mycobacteria. Equivalent to BCG2848c and Mb2852A (100%25 identity to both in 89 aa overlap);experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2828A;product=Conserved hypothetical protein;protein_id=CCP45629.1;transl_table=11
AL123456.3	EMBL	gene	3136620	3137012	.	-	.	ID=gene-Rv2829c;Name=vapC22;gbkey=Gene;gene=vapC22;gene_biotype=protein_coding;locus_tag=Rv2829c
AL123456.3	EMBL	CDS	3136620	3137012	.	-	0	ID=cds-CCP45630.1;Parent=gene-Rv2829c;Dbxref=EnsemblGenomes-Gn:Rv2829c,EnsemblGenomes-Tr:CCP45630,GOA:P71623,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45630.1;Name=CCP45630.1;Note=Rv2829c%2C (MTCY16B7.13)%2C len: 130 aa. Possible vapC22%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv2830c%2C contains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Conserved hypothetical protein similar to AAK65872|SMA2253 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (125 aa)%2CFASTA scores: opt: 171%2C E(): 7.7e-05%2C (34.9%25 identity in 129 aa overlap)%3B and shows some similarity with other proteins e.g. Q9AH69 hypothetical 14.7 KDA protein from Neisseria meningitidis (128 aa)%2C FASTA scores: opt: 148%2CE(): 0.0031%2C (28.1%25 identity in 121 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC22;locus_tag=Rv2829c;product=Possible toxin VapC22;protein_id=CCP45630.1;transl_table=11
AL123456.3	EMBL	gene	3137009	3137224	.	-	.	ID=gene-Rv2830c;Name=vapB22;gbkey=Gene;gene=vapB22;gene_biotype=protein_coding;locus_tag=Rv2830c
AL123456.3	EMBL	CDS	3137009	3137224	.	-	0	ID=cds-CCP45631.1;Parent=gene-Rv2830c;Dbxref=EnsemblGenomes-Gn:Rv2830c,EnsemblGenomes-Tr:CCP45631,GOA:P71622,InterPro:IPR006442,NCBI_GP:CCP45631.1;Name=CCP45631.1;Note=Rv2830c%2C (MTCY16B7.12)%2C len: 71 aa. Possible vapB22%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2829c%2C (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Z97182|MTCY19H5.26|Rv0596c Hypothetical protein (85 aa)%2CFASTA scores: opt: 88%2C E(): 1.3%2C (41.7%25 identity in 36 aa overlap)%3B and to PHD_BPP1|Q06253 bacteriophage P1 phd gene (73 aa)%2C FASTA scores: opt: 79%2C E(): 3.8%2C (35.9%25 identity in 39 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB22;locus_tag=Rv2830c;product=Possible antitoxin VapB22;protein_id=CCP45631.1;transl_table=11
AL123456.3	EMBL	gene	3137271	3138020	.	+	.	ID=gene-Rv2831;Name=echA16;gbkey=Gene;gene=echA16;gene_biotype=protein_coding;locus_tag=Rv2831
AL123456.3	EMBL	CDS	3137271	3138020	.	+	0	ID=cds-CCP45632.1;Parent=gene-Rv2831;Dbxref=EnsemblGenomes-Gn:Rv2831,EnsemblGenomes-Tr:CCP45632,GOA:I6YEH6,InterPro:IPR001753,InterPro:IPR029045,PDB:4JJT,UniProtKB/TrEMBL:I6YEH6,NCBI_GP:CCP45632.1;Name=CCP45632.1;Note=Rv2831%2C (MTCY16B7.11c)%2C len: 249 aa. Probable echA16%2C enoyl-CoA hydratase%2C similar to others e.g. O23468|AT4G16210 from Arabidopsis thaliana (Mouse-ear cress) (244 aa)%2C FASTA scores: opt: 491%2C E(): 7.3e-25%2C(42.1%25 identity in 190 aa overlap)%3B Q98LI4|MLL1009 from Rhizobium loti (Mesorhizobium loti) (258 aa)%2C FASTA scores: opt: 491%2C E(): 7.6e-25%2C (40.75%25 identity in 248 aa overlap)%3B O07137|ECH8_MYCLE|ML2402|MLCB1306.05c from Mycobacterium leprae (257 aa)%2C FASTA scores: opt: 478%2C E(): 5.3e-24%2C (38.05%25 identity in 226 aa overlap)%3B P76082|PAAF_ECOLI|B1393 from scherichia coli strain K12 (255 aa)%2C FASTA scores: opt: 439%2C E(): 1.9e-21%2C (37.55%25 identity in 221 aa overlap)%3B etc. Also similar to O53418|ECH8_MYCTU|ECHA8|Rv1070c|MT1100|MTV017.23c from Mycobacterium tuberculosis (257 aa)%2C FASTA scores: opt: 471%2C E(): 1.5e-23%2C (38.05%25 identity in 226 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA16;locus_tag=Rv2831;product=Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP45632.1;transl_table=11
AL123456.3	EMBL	gene	3138099	3139181	.	-	.	ID=gene-Rv2832c;Name=ugpC;gbkey=Gene;gene=ugpC;gene_biotype=protein_coding;locus_tag=Rv2832c
AL123456.3	EMBL	CDS	3138099	3139181	.	-	0	ID=cds-CCP45633.1;Parent=gene-Rv2832c;Dbxref=EnsemblGenomes-Gn:Rv2832c,EnsemblGenomes-Tr:CCP45633,GOA:I6X5H3,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR008995,InterPro:IPR012340,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:I6X5H3,NCBI_GP:CCP45633.1;Name=CCP45633.1;Note=Rv2832c%2C (MTCY16B7.10)%2C len: 360 aa. Probable ugpC%2CSn-glycerol-3-phosphate transport ATP-binding protein ABC transporter (see Braibant et al.%2C 2000)%2C similar to others: CAC48805 probable glycerol-3-phosphate ABC transporter ATP-binding protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (349 aa)%2C FASTA scores: opt: 1018%2CE(): 4.1e-53%2C (48.6%25 identity in 356 aa overlap)%3B Q98G42|MLL3499|UGPC SN-glycerol-3-phosphate transport ATP-binding protein from Rhizobium loti (Mesorhizobium loti) (366 aa)%2C FASTA scores: opt: 1016%2C E(): 5.6e-53%2C(48.5%25 identity in 367 aa overlap). But also highly similar to many msiK proteins%2C ABC transporter ATP-binding proteins possibly involved in transport of cellolbiose and maltose (see Schlosser et al.%2C 1997) e.g. P96483|MSIK MSIK protein from Streptomyces reticuli (377 aa)%2C FASTA scores: opt: 1277%2C E(): 1.9e-68%2C (58.05%25 identity in 379 aa overlap)%3B Q9L0Q1|MSIK ABC transporter ATP-binding protein from Streptomyces coelicolor (378 aa)%2C FASTA scores: opt: 1276%2CE(): 2.1e-68%2C (57.65%25 identity in 380 aa overlap)%3B Q54333|MSIK from Streptomyces lividans (314 aa)%2C FASTA scores: opt: 1217%2C E(): 5.9e-65%2C (63.7%25 identity in 292 aa overlap)%3B and other ABC-type sugar transport proteins. Also highly similar to O53482|Rv2038c|MTV018.25c ABC-type sugar transport protein from Mycobacterium tuberculosis (357 aa)%2CFASTA scores: opt: 1248%2C E(): 9.4e-67%2C (56.8%25 identity in 354 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ugpC;inference=protein motif:PROSITE:PS00211;locus_tag=Rv2832c;product=Probable Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UgpC;protein_id=CCP45633.1;transl_table=11
AL123456.3	EMBL	gene	3139174	3140484	.	-	.	ID=gene-Rv2833c;Name=ugpB;gbkey=Gene;gene=ugpB;gene_biotype=protein_coding;locus_tag=Rv2833c
AL123456.3	EMBL	CDS	3139174	3140484	.	-	0	ID=cds-CCP45634.1;Parent=gene-Rv2833c;Dbxref=EnsemblGenomes-Gn:Rv2833c,EnsemblGenomes-Tr:CCP45634,GOA:P71619,InterPro:IPR006059,InterPro:IPR006311,UniProtKB/TrEMBL:P71619,NCBI_GP:CCP45634.1;Name=CCP45634.1;Note=Rv2833c%2C (MTCY16B7.09)%2C len: 436 aa. Probable ugpB%2CSn-glycerol-3-phosphate binding lipoprotein component of Sn-glycerol-3-phosphate transport system (see citation below)%2C similar to various transporters substrate-binding periplasmic proteins e.g. Q9KDY2|BH1079 glycerol-3-phosphate ABC transporter (glycerol-3-phosphate binding protein) from Bacillus halodurans (459 aa)%2C FASTA scores: opt: 357%2C E(): 3.1e-14%2C (23.4%25 identity in 406 aa overlap)%3B P72397|male putative maltose-binding protein from Streptomyces coelicolor (423 aa)%2C FASTA scores: opt: 318%2CE(): 7e-12%2C (23.7%25 identity in 430 aa overlap)%3B AAK78409|CAC0429 glycerol-3-phosphate ABC-transporter periplasmic component from Clostridium acetobutylicum (447 aa)%2C FASTA scores: opt: 305%2C E(): 4.5e-11%2C (27.15%25 identity in 438 aa overlap)%3B P10904|UGPB_ECOLI|B3453 glycerol-3-phosphate-binding periplasmic protein precursor from Escherichia coli strain K12 (438 aa)%3B etc. Contains signal sequence and appropriately positioned prokaryotic lipoprotein attachment site (PS00013).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ugpB;locus_tag=Rv2833c;product=Probable Sn-glycerol-3-phosphate-binding lipoprotein UgpB;protein_id=CCP45634.1;transl_table=11
AL123456.3	EMBL	gene	3140487	3141314	.	-	.	ID=gene-Rv2834c;Name=ugpE;gbkey=Gene;gene=ugpE;gene_biotype=protein_coding;locus_tag=Rv2834c
AL123456.3	EMBL	CDS	3140487	3141314	.	-	0	ID=cds-CCP45635.1;Parent=gene-Rv2834c;Dbxref=EnsemblGenomes-Gn:Rv2834c,EnsemblGenomes-Tr:CCP45635,GOA:I6Y1U3,InterPro:IPR000515,UniProtKB/TrEMBL:I6Y1U3,NCBI_GP:CCP45635.1;Name=CCP45635.1;Note=Rv2834c%2C (MTCY16B7.08)%2C len: 275 aa. Probable ugpE%2CSn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below)%2C similar to various permeases e.g. Q9KDY3|BH1078 glycerol-3-phosphate ABC transporter from Bacillus halodurans (270 aa)%2C FASTA scores: opt: 620%2C E(): 4.3e-32%2C (34.7%25 identity in 268 aa overlap)%3B Q9X0K6|TM1122 glycerol-3-phosphate ABC transporter permease protein from Thermotoga maritima (276 aa)%2C FASTA scores: opt: 605%2C E(): 3.9e-31%2C (32.5%25 identity in 274 aa overlap)%3B AAG58557|UGPE SN-glycerol 3-phosphate transport system (integral membrane protein) from Escherichia coli strain O157:H7 and EDL933 (281 aa)%2C FASTA scores: opt: 574%2C E(): 3.7e-29%2C (32.95%25 identity in 264 aa overlap)%3B P10906|UGPE_ECOLI|B3451 SN-glycerol-3-phosphate transport system permease protein from Escherichia coli strain K12 (281 aa)%2C FASTA scores: opt: 569%2C E(): 7.6e-29%2C(32.6%25 identity in 264 aa overlap)%3B etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.;gbkey=CDS;gene=ugpE;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2834c;product=Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE;protein_id=CCP45635.1;transl_table=11
AL123456.3	EMBL	gene	3141311	3142222	.	-	.	ID=gene-Rv2835c;Name=ugpA;gbkey=Gene;gene=ugpA;gene_biotype=protein_coding;locus_tag=Rv2835c
AL123456.3	EMBL	CDS	3141311	3142222	.	-	0	ID=cds-CCP45636.1;Parent=gene-Rv2835c;Dbxref=EnsemblGenomes-Gn:Rv2835c,EnsemblGenomes-Tr:CCP45636,GOA:I6XFF3,InterPro:IPR000515,UniProtKB/TrEMBL:I6XFF3,NCBI_GP:CCP45636.1;Name=CCP45636.1;Note=Rv2835c%2C (MTCY1B7.07)%2C len: 303 aa. Probable ugpA%2CSn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below)%2C similar to various permeases e.g. Q9RK71|SCF11.19 probable sugar transporter inner membrane protein from Streptomyces coelicolor (316 aa)%2C FASTA scores: opt: 643%2C E(): 3.1e-35%2C (38.85%25 identity in 291 aa overlap)%3B Q9KDY4|BH1077 glycerol-3-phosphate ABC transporter (permease) from Bacillus halodurans (315 aa)%2CFASTA scores: opt: 548%2C E(): 6.2e-29%2C (31.5%25 identity in 295 aa overlap)%3B AAK78407|CAC0427 glycerol-3-phosphate ABC-transporter%2C permease component from Clostridium acetobutylicum (304 aa)%2C FASTA scores: opt: 538%2C E(): 2.8e-28%2C (29.1%25 identity in 292 aa overlap)%3B etc. Contains PS00062 Aldo/keto reductase family signature 2%2C and PS00402 Binding-protein-dependent transport systems inner membrane comp signature.;gbkey=CDS;gene=ugpA;inference=protein motif:PROSITE:PS00402;locus_tag=Rv2835c;product=Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA;protein_id=CCP45636.1;transl_table=11
AL123456.3	EMBL	gene	3142309	3143628	.	-	.	ID=gene-Rv2836c;Name=dinF;gbkey=Gene;gene=dinF;gene_biotype=protein_coding;locus_tag=Rv2836c
AL123456.3	EMBL	CDS	3142309	3143628	.	-	0	ID=cds-CCP45637.1;Parent=gene-Rv2836c;Dbxref=EnsemblGenomes-Gn:Rv2836c,EnsemblGenomes-Tr:CCP45637,GOA:P71616,InterPro:IPR002528,UniProtKB/TrEMBL:P71616,NCBI_GP:CCP45637.1;Name=CCP45637.1;Note=Rv2836c%2C (MTCY16B7.06)%2C len: 439 aa. Possible dinF%2CDNA-damage-inducible protein F%2C integral membrane protein%2Csimilar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 (459 aa)%2C FASTA scores: opt: 501%2C E(): 2.7e-21%2C (29.55%25 identity in 443 aa overlap)%3B P28303|DINF_ECOLI|B4044 from Escherichia coli strain K12 (459 aa)%2C FASTA scores: opt: 491%2C E(): 1e-20%2C(29.35%25 identity in 443 aa overlap)%3B Q98B90|MLR5680 from Rhizobium loti (Mesorhizobium loti) (471 aa)%2C FASTA scores: opt: 466%2C E(): 2.7e-19%2C (30.7%25 identity in 433 aa overlap)%3B etc. But also similar or highly similar to other hypothetical proteins e.g. Q9X8U6|SCH24.32c hypothetical 46.3 KDA protein from Streptomyces coelicolor (448 aa)%2CFASTA scores: opt: 981%2C E(): 1.1e-48%2C (42.35%25 identity in 437 aa overlap). Contains PS00213 Lipocalin signature.;gbkey=CDS;gene=dinF;inference=protein motif:PROSITE:PS00213;locus_tag=Rv2836c;product=Possible DNA-damage-inducible protein F DinF;protein_id=CCP45637.1;transl_table=11
AL123456.3	EMBL	gene	3143635	3144645	.	-	.	ID=gene-Rv2837c;Name=Rv2837c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2837c
AL123456.3	EMBL	CDS	3143635	3144645	.	-	0	ID=cds-CCP45638.1;Parent=gene-Rv2837c;Dbxref=EnsemblGenomes-Gn:Rv2837c,EnsemblGenomes-Tr:CCP45638,GOA:P71615,InterPro:IPR001667,InterPro:IPR003156,NCBI_GP:CCP45638.1;Name=CCP45638.1;Note=Rv2837c%2C (MTCY16B7.05)%2C len: 336 aa. Conserved protein%2C showing some similarity with other proteins e.g. O67552|AQ_1630 hypothetical 36.2 KDA protein from Aquifex aeolicus (325 aa)%2C FASTA scores: opt: 498%2C E(): 3.6e-25%2C(32.8%25 identity in 314 aa overlap)%3B Q9X1T1|TM1595 conserved hypothetical protein from Thermotoga maritima (333 aa)%2CFASTA scores: opt: 482%2C E(): 4.1e-24%2C (34.85%25 identity in 304 aa overlap)%3B Q9RW43|DR0826 conserved hypothetical protein from Deinococcus radiodurans (338 aa)%2C FASTA scores: opt: 444%2C E(): 1.3e-21%2C (33.85%25 identity in 331 aa overlap)%3B etc. Equivalent to AAK47229 from Mycobacterium tuberculosis strain CDC1551 (316 aa) but longer 20 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2837c;product=Conserved protein;protein_id=CCP45638.1;transl_table=11
AL123456.3	EMBL	gene	3144620	3145171	.	-	.	ID=gene-Rv2838c;Name=rbfA;gbkey=Gene;gene=rbfA;gene_biotype=protein_coding;locus_tag=Rv2838c
AL123456.3	EMBL	CDS	3144620	3145171	.	-	0	ID=cds-CCP45639.1;Parent=gene-Rv2838c;Dbxref=EnsemblGenomes-Gn:Rv2838c,EnsemblGenomes-Tr:CCP45639,GOA:P9WHJ7,InterPro:IPR000238,InterPro:IPR015946,InterPro:IPR020053,InterPro:IPR023799,NCBI_GP:CCP45639.1;Name=CCP45639.1;Note=Rv2838c%2C (MTCY16B7.04)%2C len: 183 aa. Probable rbfA%2Cribosome-binding factor A%2C equivalent to Q9Z5I8|RBFA_MYCLE|ML1555|MLCB596.15 probable ribosome-binding factor a from Mycobacterium leprae (164 aa)%2C FASTA scores: opt: 739%2C E(): 1.8e-40%2C (75.6%25 identity in 160 aa overlap). Also highly similar or similar to others e.g. Q9Z527|RBFA_STRCO|SC9F2.08c from Streptomyces coelicolor (160 aa)%2C FASTA scores: opt: 425%2C E(): 2.8e-20%2C(50.35%25 identity in 141 aa overlap)%3B P32731|RBFA_BACSU from Bacillus subtilis (117 aa)%2C FASTA scores: opt: 199%2C E(): 7.8e-06%2C (32.4%25 identity in 108 aa overlap)%3B P09170|RBFA_ECOLI|P15B|B3167 from Escherichia coli strain K12 (132 aa)%2C FASTA scores: opt: 166%2C E(): 0.0011%2C (29.65%25 identity in 118 aa overlap)%3B etc. Belongs to the RBFA family. Note that appears to be longer in C-terminus than other RbfA proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rbfA;locus_tag=Rv2838c;product=Probable ribosome-binding factor a RbfA (P15B protein);protein_id=CCP45639.1;transl_table=11
AL123456.3	EMBL	gene	3145171	3147873	.	-	.	ID=gene-Rv2839c;Name=infB;gbkey=Gene;gene=infB;gene_biotype=protein_coding;locus_tag=Rv2839c
AL123456.3	EMBL	CDS	3145171	3147873	.	-	0	ID=cds-CCP45640.1;Parent=gene-Rv2839c;Dbxref=EnsemblGenomes-Gn:Rv2839c,EnsemblGenomes-Tr:CCP45640,GOA:P9WKK1,InterPro:IPR000178,InterPro:IPR000795,InterPro:IPR004161,InterPro:IPR005225,InterPro:IPR006847,InterPro:IPR009000,InterPro:IPR015760,InterPro:IPR023115,InterPro:IPR027417,NCBI_GP:CCP45640.1;Name=CCP45640.1;Note=Rv2839c%2C (MTCY16B7.03)%2C len: 900 aa. Probable infB%2Ctranslation initiation factor if-2%2C highly similar%2C but in part%2C to Q9Z5I9|IF2_MYCLE|ML1556|MLCB596.14 translation initiation factor if-2 from Mycobacterium leprae (924 aa)%2CFASTA scores: opt: 4548%2C E(): 2.4e-132%2C (83.6%25 identity in 933 aa overlap). Also similar in part to others e.g. Q9K3E2|SC5H4.30 from Streptomyces coelicolor (835 aa)%2CFASTA scores: opt: 2559%2C E(): 1.3e-71%2C (59.9%25 identity in 833 aa overlap)%3B P17889|IF2_BACSU|INFB from Bacillus subtilis (716 aa)%2C FASTA scores: opt: 1782%2C E(): 6.6e-48%2C(46.65%25 identity in 686 aa overlap)%3B P02995|IF2_ECOLI|INFB|SSYG|B3168|Z4529|ECS4049 from Escherichia coli strains O157:H7 and K12 (890 aa)%2C FASTA scores: opt: 1708%2C E(): 1.3e-45%2C (46.2%25 identity in 662 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the if-2 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=infB;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2839c;product=Probable translation initiation factor if-2 InfB;protein_id=CCP45640.1;transl_table=11
AL123456.3	EMBL	gene	3147959	3148258	.	-	.	ID=gene-Rv2840c;Name=Rv2840c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2840c
AL123456.3	EMBL	CDS	3147959	3148258	.	-	0	ID=cds-CCP45641.1;Parent=gene-Rv2840c;Dbxref=EnsemblGenomes-Gn:Rv2840c,EnsemblGenomes-Tr:CCP45641,InterPro:IPR007393,UniProtKB/TrEMBL:I6XFF7,NCBI_GP:CCP45641.1;Name=CCP45641.1;Note=Rv2840c%2C (MTCY16B7.02)%2C len: 99 aa. Conserved hypothetical protein%2C equivalent to Q9Z5J0|ML1557|MLCB596.13 hypothetical 11.6 KDA protein from Mycobacterium leprae (106 aa)%2C FASTA scores: opt: 501%2C E(): 2.3e-29%2C (501%25 identity in 96 aa overlap). Also highly similar to other hypothetical proteins e.g. Q9KYR0|SC5H4.29 from Streptomyces coelicolor (101 aa)%2C FASTA scores: opt: 256%2C E(): 1.4e-11%2C (50.6%25 identity in 81 aa overlap)%3B Q9APM9 from Myxococcus xanthus (111 aa)%2C FASTA scores: opt: 174%2C E(): 1.3e-05%2C (42.25%25 identity in 97 aa overlap)%3B and similar to to others e.g. N-terminus of CAC41675|SMC02913 from Rhizobium meliloti (Sinorhizobium meliloti) (230 aa)%2CFASTA scores: opt: 172%2C E(): 3e-05%2C (42.4%25 identity in 66 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2840c;product=Conserved hypothetical protein;protein_id=CCP45641.1;transl_table=11
AL123456.3	EMBL	gene	3148385	3149428	.	-	.	ID=gene-Rv2841c;Name=nusA;gbkey=Gene;gene=nusA;gene_biotype=protein_coding;locus_tag=Rv2841c
AL123456.3	EMBL	CDS	3148385	3149428	.	-	0	ID=cds-CCP45642.1;Parent=gene-Rv2841c;Dbxref=EnsemblGenomes-Gn:Rv2841c,EnsemblGenomes-Tr:CCP45642,GOA:P9WIV3,InterPro:IPR003029,InterPro:IPR004087,InterPro:IPR004088,InterPro:IPR009019,InterPro:IPR010213,InterPro:IPR012340,InterPro:IPR013735,InterPro:IPR015946,InterPro:IPR022967,InterPro:IPR025249,InterPro:IPR028620,PDB:1K0R,PDB:2ASB,PDB:2ATW,NCBI_GP:CCP45642.1;Name=CCP45642.1;Note=Rv2841c%2C (MTCY24A1.16%2C MTCY16B7.01)%2C len: 347 aa. Probable nusA%2C N-utilization substance protein A%2Cequivalent to Q9Z5J1|NUSA|ML1558 probable transcription termination/antitermination factor from Mycobacterium leprae (347 aa)%2C FASTA scores: opt: 2054%2C E(): 5.4e-120%2C(91.95%25 identity in 347 aa overlap). Also highly similar to others e.g. Q9KYR1|SC5H4.28 putative transcriptional termination/antitermination factor from Streptomyces coelicolor (340 aa)%2C FASTA scores: opt: 1346%2C E(): 4.3e-76%2C(63.35%25 identity in 341 aa overlap)%3B P32727|NUSA_BACSU N utilization substance protein A (371 aa)%2C FASTA scores: opt: 847%2C E(): 4.1e-45%2C (43.95%25 identity in 346 aa overlap)%3B Q9KA74|NUSA|BH2416 transcriptional terminator from Bacillus halodurans (382 aa)%2C FASTA scores: opt: 846%2CE(): 4.8e-45%2C (43.15%25 identity in 373 aa overlap)%3B etc. Belongs to the NUSA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nusA;locus_tag=Rv2841c;product=Probable N utilization substance protein A NusA;protein_id=CCP45642.1;transl_table=11
AL123456.3	EMBL	gene	3149425	3149976	.	-	.	ID=gene-Rv2842c;Name=Rv2842c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2842c
AL123456.3	EMBL	CDS	3149425	3149976	.	-	0	ID=cds-CCP45643.1;Parent=gene-Rv2842c;Dbxref=EnsemblGenomes-Gn:Rv2842c,EnsemblGenomes-Tr:CCP45643,GOA:P9WH17,InterPro:IPR003728,InterPro:IPR028989,InterPro:IPR028998,NCBI_GP:CCP45643.1;Name=CCP45643.1;Note=Rv2842c%2C (MTCY24A1.15)%2C len: 183 aa. Conserved protein%2C similar to Q9Z5J2|MLCB596.11 hypothetical 13.7 KDA protein from Mycobacterium leprae (122 aa)%2C FASTA scores: opt: 192%2C E(): 2.1e-12%2C (50.0%25 identity in 128 aa overlap) (N-terminus shorter). Also similar in part to several hypothetical proteins e.g. Q9KYR2|SC5H4.27 hypothetical 19.8 KDA protein from Streptomyces coelicolor (177 aa)%2CFASTA scores: opt: 288%2C E(): 2.1e-12%2C (37.15%25 identity in 148 aa overlap)%3B O66619|Y260_AQUAE|AQ_260 hypothetical protein from Aquifex aeolicus (158 aa)%2C FASTA scores: opt: 230%2C E(): 1.7e-08%2C (31.35%25 identity in 153 aa overlap)%3B Q9KU82|VC0641 hypothetical protein from Vibrio cholerae (151 aa)%2C FASTA scores: opt: 198%2C E(): 2.5e-06%2C (30.9%25 identity in 152 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2842c;product=Conserved protein;protein_id=CCP45643.1;transl_table=11
AL123456.3	EMBL	gene	3150171	3150716	.	+	.	ID=gene-Rv2843;Name=Rv2843;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2843
AL123456.3	EMBL	CDS	3150171	3150716	.	+	0	ID=cds-CCP45644.1;Parent=gene-Rv2843;Dbxref=EnsemblGenomes-Gn:Rv2843,EnsemblGenomes-Tr:CCP45644,GOA:I6YAE2,InterPro:IPR006311,UniProtKB/TrEMBL:I6YAE2,NCBI_GP:CCP45644.1;Name=CCP45644.1;Note=Rv2843%2C (MTCY24A1.14c)%2C len: 181 aa. Probable conserved transmembrane ala-rich protein%2C equivalent to Q9Z5J3|ML1560|MLCB596.10c hypothetical 17.5 KDA protein from Mycobacterium leprae (178 aa)%2C FASTA scores: opt: 707%2CE(): 1.4e-32%2C (70.25%25 identity in 168 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2843;product=Probable conserved transmembrane alanine rich protein;protein_id=CCP45644.1;transl_table=11
AL123456.3	EMBL	gene	3150713	3151201	.	+	.	ID=gene-Rv2844;Name=Rv2844;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2844
AL123456.3	EMBL	CDS	3150713	3151201	.	+	0	ID=cds-CCP45645.1;Parent=gene-Rv2844;Dbxref=EnsemblGenomes-Gn:Rv2844,EnsemblGenomes-Tr:CCP45645,InterPro:IPR009078,InterPro:IPR012347,InterPro:IPR029447,UniProtKB/TrEMBL:I6Y1V1,NCBI_GP:CCP45645.1;Name=CCP45645.1;Note=Rv2844%2C (MTCY24A1.13c)%2C len: 162 aa. Conserved ala-rich protein%2C equivalent to Q9Z5J4|ML1561|MLCB596.09c hypothetical 17.5 KDA protein from Mycobacterium leprae (165 aa)%2C FASTA scores: opt: 771%2C E(): 4.9e-46%2C (71.5%25 identity in 165 aa overlap). Also similar to Q9KYR4|SC5H4.25c hypothetical 16.8 KDA protein from Streptomyces coelicolor (167 aa)%2C FASTA scores: opt: 242%2CE(): 1.6e-09%2C (38.9%25 identity in 144 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2844;product=Conserved alanine rich protein;protein_id=CCP45645.1;transl_table=11
AL123456.3	EMBL	gene	3151202	3152950	.	-	.	ID=gene-Rv2845c;Name=proS;gbkey=Gene;gene=proS;gene_biotype=protein_coding;locus_tag=Rv2845c
AL123456.3	EMBL	CDS	3151202	3152950	.	-	0	ID=cds-CCP45646.1;Parent=gene-Rv2845c;Dbxref=EnsemblGenomes-Gn:Rv2845c,EnsemblGenomes-Tr:CCP45646,GOA:P9WFT9,InterPro:IPR002314,InterPro:IPR002316,InterPro:IPR004154,InterPro:IPR004500,InterPro:IPR006195,InterPro:IPR007214,InterPro:IPR023717,NCBI_GP:CCP45646.1;Name=CCP45646.1;Note=Rv2845c%2C (MTCY24A1.12)%2C len: 582 aa. Probable proS%2Cprolyl-tRNA synthetase%2C highly similar to others e.g. Q9KYR6|SYP_STRCO|pros|SC5H4.23 from Streptomyces coelicolor (567 aa)%2C FASTA scores: opt: 1161%2C E(): 9e-64%2C (57.15%25 identity in 574 aa overlap)%3B P56124|SYP_HELPY|pros|HP0238 from Helicobacter pylori (Campylobacter pylori) (577 aa)%2CFASTA scores: opt: 1082%2C E(): 6.6e-59%2C (37.8%25 identity in 553 aa overlap)%3B P16659|SYP_ECOLI|pros|DRPA|B0194 from Escherichia coli strain K12 (572 aa)%2C FASTA scores: opt: 926%2C E(): 2.6e-49%2C (39.85%25 identity in 587 aa overlap)%3B etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=proS;inference=protein motif:PROSITE:PS00179;locus_tag=Rv2845c;product=Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase);protein_id=CCP45646.1;transl_table=11
AL123456.3	EMBL	gene	3153039	3154631	.	-	.	ID=gene-Rv2846c;Name=efpA;gbkey=Gene;gene=efpA;gene_biotype=protein_coding;locus_tag=Rv2846c
AL123456.3	EMBL	CDS	3153039	3154631	.	-	0	ID=cds-CCP45647.1;Parent=gene-Rv2846c;Dbxref=EnsemblGenomes-Gn:Rv2846c,EnsemblGenomes-Tr:CCP45647,GOA:P9WJY5,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP45647.1;Name=CCP45647.1;Note=Rv2846c%2C (MTCY24A1.11)%2C len: 530 aa. Possible efpA%2Cintegral membrane efflux protein%2C member of major facilitator superfamily (MFS) possibly involved in transport of drug (see citations below)%2C equivalent to Q9Z5J5|ML1562|MLCB596.08 putative transmembrane efflux protein from Mycobacterium leprae (534 aa)%2C FASTA scores: opt: 2881%2C E(): 4.1e-160%2C (86.55%25 identity in 535 aa overlap). Also highly similar to several membrane proteins e.g. O69986|SC4H2.31c transmembrane efflux protein (515 aa)%2C FASTA scores: opt: 1063%2C E(): 2.2e-54%2C (39.65%25 identity in 406 aa overlap)%3B Q9FBQ5|SCD86A.02c putative transport integral membrane protein from Streptomyces coelicolor (503 aa)%2C FASTA scores: opt: 918%2C E(): 5.8e-46%2C(33.7%25 identity in 469 aa overlap)%3B Q9KYU0|SCE22.23c putative transmembrane efflux protein from Streptomyces coelicolor (514 aa)%2C FASTA scores: opt: 888%2C E(): 3.3e-44%2C(32.85%25 identity in 469 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=efpA;locus_tag=Rv2846c;product=Possible integral membrane efflux protein EfpA;protein_id=CCP45647.1;transl_table=11
AL123456.3	EMBL	gene	3154654	3155871	.	-	.	ID=gene-Rv2847c;Name=cysG;gbkey=Gene;gene=cysG;gene_biotype=protein_coding;gene_synonym=cysG2;locus_tag=Rv2847c
AL123456.3	EMBL	CDS	3154654	3155871	.	-	0	ID=cds-CCP45648.1;Parent=gene-Rv2847c;Dbxref=EnsemblGenomes-Gn:Rv2847c,EnsemblGenomes-Tr:CCP45648,GOA:I6X5I7,InterPro:IPR000878,InterPro:IPR006366,InterPro:IPR006367,InterPro:IPR012409,InterPro:IPR014776,InterPro:IPR014777,InterPro:IPR016040,UniProtKB/TrEMBL:I6X5I7,NCBI_GP:CCP45648.1;Name=CCP45648.1;Note=Rv2847c%2C (MTCY24A1.10)%2C len: 405 aa. Possible cysG%2Cmultifunctional enzyme%2C siroheme synthase containing uroporphyrin-III c-methyltransferase%2C precorrin-2 oxidase and ferrochelatase. C-terminus highly similar to many uroporphyrin-III c-methyltransferases e.g. Q51720|COBA uroporphyrinogen III methyltransferase from Propionibacterium freudenreichii (257 aa)%2C FASTA scores: opt: 776%2C E(): 1.5e-39%2C (48.95%25 identity in 243 aa overlap)%3B Q9HMY4|UROM|VNG2331G S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase from Halobacterium sp. strain NRC-1 (246 aa)%2C FASTA scores: opt: 704%2C E(): 3.1e-35%2C (49.4%25 identity in 245 aa overlap)%3B P42437|NASF_BACSU|NASBE uroporphyrin-III C-methyltransferase from Bacillus subtilis (483 aa)%2C FASTA scores: opt: 610%2C E(): 2.4e-29%2C (42.1%25 identity in 240 aa overlap)%3B etc. And highly similar over entire length to other proteins e.g. Q9L1C9|SCL11.09c uroporphyrinogen III methyltransferase from Streptomyces coelicolor (410 aa)%2C FASTA scores: opt: 1481%2C E(): 5.6e-82%2C(58.45%25 identity in 409 aa overlap)%3B Q9I0M7|CYSG|PA2611 siroheme synthase from Pseudomonas aeruginosa (465 aa)%2CFASTA scores: opt: 609%2C E(): 2.7e-29%2C (34.7%25 identity in 444 aa overlap)%3B P11098|CYSG_ECOLI|B3368|Z4729|ECS4219 siroheme synthase from Escherichia coli stains O157:H7 and K12 (457 aa)%2C FASTA scores: opt: 543%2C E(): 9.1e-27%2C (31.3%25 identity in 450 aa overlap)%3B etc. Belongs to a family that groups SUMT%2C CYSG%2C CBIF/COBM and CBIL/COBI. Note that previously known as cysG2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysG;locus_tag=Rv2847c;product=Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase;protein_id=CCP45648.1;transl_table=11
AL123456.3	EMBL	repeat_region	3155874	3155927	.	-	.	ID=id-AL123456.3:3155874..3155927;Note=54 bp direct repeat 4%2CGGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTAGGCTTGGC;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3155928	3155981	.	-	.	ID=id-AL123456.3:3155928..3155981;Note=54 bp direct repeat 3%2CGGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3155982	3156035	.	-	.	ID=id-AL123456.3:3155982..3156035;Note=54 bp direct repeat 2%2CGGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3156036	3156089	.	-	.	ID=id-AL123456.3:3156036..3156089;Note=54 bp direct repeat 1%2CGGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT;gbkey=repeat_region
AL123456.3	EMBL	gene	3156148	3157521	.	-	.	ID=gene-Rv2848c;Name=cobB;gbkey=Gene;gene=cobB;gene_biotype=protein_coding;locus_tag=Rv2848c
AL123456.3	EMBL	CDS	3156148	3157521	.	-	0	ID=cds-CCP45649.1;Parent=gene-Rv2848c;Dbxref=EnsemblGenomes-Gn:Rv2848c,EnsemblGenomes-Tr:CCP45649,GOA:P9WP97,InterPro:IPR002586,InterPro:IPR004484,InterPro:IPR011698,InterPro:IPR017929,InterPro:IPR027417,InterPro:IPR029062,NCBI_GP:CCP45649.1;Name=CCP45649.1;Note=Rv2848c%2C (MTCY24A1.09)%2C len: 457 aa. Probable cobB%2Ccobyrinic acid A%2CC-diamide synthase%2C highly similar to others e.g. O27509|COBB_METTH|MTH1460 from Methanobacterium thermoautotrophicum (447 aa)%2C FASTA scores: opt: 980%2C E(): 1.3e-49%2C (39.65%25 identity in 454 aa overlap)%3B Q9KBM8|BH1898 from Bacillus halodurans (465 aa)%2C FASTA scores: opt: 928%2CE(): 1.4e-46%2C (37.0%25 identity in 457 aa overlap)%3B O68108|COBB_RHOCA from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (435 aa)%2C FASTA scores: opt: 921%2C E(): 3.3e-46%2C (39.35%25 identity in 437 aa overlap)%3B etc. Belongs to the COBB/COBQ family%2C COBB subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobB;locus_tag=Rv2848c;product=Probable cobyrinic acid A%2CC-diamide synthase CobB;protein_id=CCP45649.1;transl_table=11
AL123456.3	EMBL	gene	3157521	3158144	.	-	.	ID=gene-Rv2849c;Name=cobO;gbkey=Gene;gene=cobO;gene_biotype=protein_coding;gene_synonym=cobA;locus_tag=Rv2849c
AL123456.3	EMBL	CDS	3157521	3158144	.	-	0	ID=cds-CCP45650.1;Parent=gene-Rv2849c;Dbxref=EnsemblGenomes-Gn:Rv2849c,EnsemblGenomes-Tr:CCP45650,GOA:I6Y1V6,InterPro:IPR003724,InterPro:IPR027417,UniProtKB/TrEMBL:I6Y1V6,NCBI_GP:CCP45650.1;Name=CCP45650.1;Note=Rv2849c%2C (MTCY24A1.08)%2C len: 207 aa. Probable cobO%2Ccob(I)alamin adenosyltransferase%2C highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa)%2C FASTA scores: opt: 918%2C E(): 1.1e-55%2C (64.75%25 identity in 207 aa overlap)%3B and similar to others e.g. O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212 aa)%2C FASTA scores: opt: 329%2C E(): 2.8e-15%2C (44.3%25 identity in 185 aa overlap)%3B P29930|COBO_PSEDE from Pseudomonas denitrificans (213 aa)%2C FASTA scores: opt: 280%2C E(): 6.5e-12%2C (38.9%25 identity in 185 aa overlap)%3B P31570|BTUR_SALTY|COBA from Salmonella typhimurium (196 aa)%2C FASTA scores: opt: 278%2C E(): 8.4e-12%2C (39.8%25 identity in 196 aa overlap)%3B etc. Cofactor: manganese. Note that previously known as cobA.;gbkey=CDS;gene=cobO;locus_tag=Rv2849c;product=Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity);protein_id=CCP45650.1;transl_table=11
AL123456.3	EMBL	gene	3158165	3160054	.	-	.	ID=gene-Rv2850c;Name=Rv2850c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2850c
AL123456.3	EMBL	CDS	3158165	3160054	.	-	0	ID=cds-CCP45651.1;Parent=gene-Rv2850c;Dbxref=EnsemblGenomes-Gn:Rv2850c,EnsemblGenomes-Tr:CCP45651,GOA:P9WPR3,InterPro:IPR002035,InterPro:IPR003593,InterPro:IPR011704,InterPro:IPR027417,NCBI_GP:CCP45651.1;Name=CCP45651.1;Note=Rv2850c%2C (MTCY24A1.07)%2C len: 629 aa. Possible magnesium-chelatase%2C highly similar (but with gaps) to magnesium-chelatases from notably photosynthetic organisms involved in chlorophyll biosynthesis e.g. Q9RJ18|SCI8.35c putative chelatase from Streptomyces coelicolor (672 aa)%2CFASTA scores: opt: 1941%2C E(): 2.1e-85%2C (54.65%25 identity in 675 aa overlap)%3B Q9HZQ5|PA2942 probable magnesium chelatase from Pseudomonas aeruginosa (338 aa)%2C FASTA scores: opt: 991%2C E(): 2.7e-40%2C (49.45%25 identity in 368 aa overlap)%3B O33549|BCHI mg protoporphyrin IX chelatase subunit from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa)%2C FASTA scores: opt: 833%2C E(): 9.4e-33%2C (50.65%25 identity in 318 aa overlap)%3B O30819|BCHI_RHOSH magnesium-chelatase 38 KDA subunit from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (334 aa)%2C FASTA scores: opt: 828%2C E(): 1.6e-32%2C (50.3%25 identity in 318 aa overlap)%3B etc. Equivalent to AAK47242 from Mycobacterium tuberculosis strain CDC1551 (610 aa) but longer 19 aa. COULB belong to the mg-chelatase subunits D/I family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2850c;product=Possible magnesium chelatase;protein_id=CCP45651.1;transl_table=11
AL123456.3	EMBL	gene	3160051	3160521	.	-	.	ID=gene-Rv2851c;Name=Rv2851c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2851c
AL123456.3	EMBL	CDS	3160051	3160521	.	-	0	ID=cds-CCP45652.1;Parent=gene-Rv2851c;Dbxref=EnsemblGenomes-Gn:Rv2851c,EnsemblGenomes-Tr:CCP45652,GOA:P9WFQ5,InterPro:IPR000182,InterPro:IPR016181,NCBI_GP:CCP45652.1;Name=CCP45652.1;Note=Rv2851c%2C (MTCY24A1.06)%2C len: 156 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Similar to others e.g. Q9KP14|VC2565 ELAA protein from Vibrio cholerae (149 aa)%2C FASTA scores: opt: 360%2C E(): 1e-18%2C (46.05%25 identity in 139 aa overlap)%3B Q9I717|PA0115 hypothetical protein from Pseudomonas aeruginosa (150 aa)%2CFASTA scores: opt: 341%2C E(): 2.4e-17%2C (43.65%25 identity in 142 aa overlap)%3B Q9K8M4|BH2982 hypothetical protein from Bacillus halodurans (155 aa)%2C FASTA scores: opt: 320%2C E(): 8e-16%2C (40.85%25 identity in 142 aa overlap)%3B P52077|ELAA_ECOLI|B2267 protein ELAA from Escherichia coli strain K12 (153 aa)%2C FASTA scores: opt: 269%2C E(): 3.8e-12%2C(35.7%25 identity in 140 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2851c;product=GCN5-related N-acetyltransferase;protein_id=CCP45652.1;transl_table=11
AL123456.3	EMBL	repeat_region	3160522	3160583	.	-	.	ID=id-AL123456.3:3160522..3160583;Note=62 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	gene	3160580	3162061	.	-	.	ID=gene-Rv2852c;Name=mqo;gbkey=Gene;gene=mqo;gene_biotype=protein_coding;locus_tag=Rv2852c
AL123456.3	EMBL	CDS	3160580	3162061	.	-	0	ID=cds-CCP45653.1;Parent=gene-Rv2852c;Dbxref=EnsemblGenomes-Gn:Rv2852c,EnsemblGenomes-Tr:CCP45653,GOA:P9WJP5,InterPro:IPR006231,NCBI_GP:CCP45653.1;Name=CCP45653.1;Note=Rv2852c%2C (MT2918%2C MTCY24A1.05)%2C len: 493 aa. Probable mqo%2C malate:quinone oxidoreductase%2C highly similar to others e.g. O69282|MQO_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (499 aa)%2C FASTA scores: opt: 1701%2C E(): 1.2e-101%2C (50.7%25 identity in 495 aa overlap)%3B Q9Z9Q7|BH3960 from Bacillus halodurans (500 aa)%2CFASTA scores: opt: 1632%2C E(): 3.3e-97%2C (48.55%25 identity in 486 aa overlap)%3B Q9HYF4|MQOA|PA3452 from Pseudomonas aeruginosa (523 aa)%2C FASTA scores: opt: 1604%2C E(): 2.1e-95%2C(49.1%25 identity in 487 aa overlap) (N-terminus longer)%3B P33940|MQO_ECOLI|B2210 from Escherichia coli strain K12 (548 aa)%2C FASTA scores: opt: 1525%2C E(): 2.7e-90%2C (48.15%25 identity in 492 aa overlap)%3B etc. Belongs to the MQO family. Cofactors: FAD.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mqo;locus_tag=Rv2852c;product=Probable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor]);protein_id=CCP45653.1;transl_table=11
AL123456.3	EMBL	gene	3162268	3164115	.	+	.	ID=gene-Rv2853;Name=PE_PGRS48;gbkey=Gene;gene=PE_PGRS48;gene_biotype=protein_coding;locus_tag=Rv2853
AL123456.3	EMBL	CDS	3162268	3164115	.	+	0	ID=cds-CCP45654.1;Parent=gene-Rv2853;Dbxref=EnsemblGenomes-Gn:Rv2853,EnsemblGenomes-Tr:CCP45654,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MX26,NCBI_GP:CCP45654.1;Name=CCP45654.1;Note=Rv2853%2C (MTCY24A1.04c)%2C len: 615 aa. PE_PGRS48%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to many e.g. O53884|Rv0872c|MTV043.65c from Mycobacterium tuberculosis (606 aa)%2C FASTA scores: opt: 1405%2C E(): 1.4e-97%2C (64.6%25 identity in 619 aa overlap). Equivalent to AAK47245 from Mycobacterium tuberculosis strain CDC1551 (663 aa) but shorter 48 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS48;locus_tag=Rv2853;product=PE-PGRS family protein PE_PGRS48;protein_id=CCP45654.1;transl_table=11
AL123456.3	EMBL	gene	3164152	3165192	.	+	.	ID=gene-Rv2854;Name=Rv2854;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2854
AL123456.3	EMBL	CDS	3164152	3165192	.	+	0	ID=cds-CCP45655.1;Parent=gene-Rv2854;Dbxref=EnsemblGenomes-Gn:Rv2854,EnsemblGenomes-Tr:CCP45655,GOA:O05805,InterPro:IPR029058,UniProtKB/TrEMBL:O05805,NCBI_GP:CCP45655.1;Name=CCP45655.1;Note=Rv2854%2C (MTCY24A1.03c)%2C len: 346 aa. Unknown protein%2C showing similarity with Q9CD03|ML2603 hypothetical protein from Mycobacterium leprae (279 aa)%2C FASTA scores: opt: 154%2C E(): 0.0083%2C (33.35%25 identity in 87 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2854;product=Unknown protein;protein_id=CCP45655.1;transl_table=11
AL123456.3	EMBL	gene	3165205	3166584	.	+	.	ID=gene-Rv2855;Name=mtr;gbkey=Gene;gene=mtr;gene_biotype=protein_coding;gene_synonym=gorA;locus_tag=Rv2855
AL123456.3	EMBL	CDS	3165205	3166584	.	+	0	ID=cds-CCP45656.1;Parent=gene-Rv2855;Dbxref=EnsemblGenomes-Gn:Rv2855,EnsemblGenomes-Tr:CCP45656,GOA:P9WHH3,InterPro:IPR001327,InterPro:IPR004099,InterPro:IPR012999,InterPro:IPR013027,InterPro:IPR016156,InterPro:IPR017817,InterPro:IPR023753,NCBI_GP:CCP45656.1;Name=CCP45656.1;Note=Rv2855%2C (MTCY24A1.02c)%2C len: 459 aa. Mtr%2CNADPH-dependent mycothiol reductase%2C proven enzymatically but previously described as glutathione reductase homolog (gene name: gorA) (see citation below). Similar to others e.g. Q9L7K8|MERA mercuric reductase from Streptomyces sp. CHR28 (474 aa)%2C FASTA scores: opt: 719%2C E(): 9e-38%2C (35.2%25 identity in 460 aa overlap)%3B P30341|MERA_STRLI mercuric reductase from Streptomyces lividans (474 aa)%2C FASTA scores: opt: 712%2C E(): 2.5e-37%2C (34.95%25 identity in 455 aa overlap)%3B Q98ED5|MLL4296 ferric leghemoglobin reductase-2 precursor%2C dihydrolipoamide dehydrogenase from Rhizobium loti (Mesorhizobium loti) (468 aa)%2C FASTA scores: opt: 670%2CE(): 1.1e-34%2C (30.8%25 identity in 471 aa overlap)%3B etc. Belongs to the pyridine nucleotide-disulphide oxidoreductases class-I. Cofactor: FAD.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mtr;locus_tag=Rv2855;product=NADPH-dependent mycothiol reductase Mtr;protein_id=CCP45656.1;transl_table=11
AL123456.3	EMBL	gene	3166684	3167802	.	+	.	ID=gene-Rv2856;Name=nicT;gbkey=Gene;gene=nicT;gene_biotype=protein_coding;locus_tag=Rv2856
AL123456.3	EMBL	CDS	3166684	3167802	.	+	0	ID=cds-CCP45657.1;Parent=gene-Rv2856;Dbxref=EnsemblGenomes-Gn:Rv2856,EnsemblGenomes-Tr:CCP45657,GOA:I6YEJ7,InterPro:IPR004688,InterPro:IPR011541,UniProtKB/TrEMBL:I6YEJ7,NCBI_GP:CCP45657.1;Name=CCP45657.1;Note=Rv2856%2C (MTCY24A1.01c)%2C len: 372 aa. Possible nicT%2Cnickel-transport integral membrane protein%2C similar to transport proteins and hydrogenase cluster proteins e.g. BAB58860|SAV2698 hypothetical 37.9 KDA protein from Staphylococcus aureus subsp. aureus Mu50 (338 aa)%2C FASTA scores: opt: 1082%2C E(): 7.1e-60%2C (48.05%25 identity in 335 aa overlap)%3B Q97ZB2|HOXN high-affinity nickel-transport protein from Sulfolobus solfataricus (373 aa)%2C FASTA scores: opt: 922%2C E(): 6.6e-50%2C (42.2%25 identity in 372 aa overlap)%3B P23516|HOXN_ALCEU high-affinity nickel transport protein (integral membrane protein) from Alcaligenes eutrophus (Ralstonia eutropha) (351 aa)%2C FASTA scores: opt: 904%2C E(): 8.3e-49%2C (41.9%25 identity in 339 aa overlap)%3B Q45247|HUPN_BRAJA hydrogenase nickel incorporation protein from Bradyrhizobium japonicum (381 aa)%2C FASTA scores: opt: 853%2C E(): 1.3e-45%2C (41.65%25 identity in 329 aa overlap)%3B etc. Seems to belong to the HOXN/HUPN/NIXA family of nickel transporters (NiCoT family).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nicT;inference=protein motif:PROSITE:PS00190;locus_tag=Rv2856;product=Possible nickel-transport integral membrane protein NicT;protein_id=CCP45657.1;transl_table=11
AL123456.3	EMBL	gene	3168583	3169359	.	-	.	ID=gene-Rv2857c;Name=Rv2857c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2857c
AL123456.3	EMBL	CDS	3168583	3169359	.	-	0	ID=cds-CCP45658.1;Parent=gene-Rv2857c;Dbxref=EnsemblGenomes-Gn:Rv2857c,EnsemblGenomes-Tr:CCP45658,GOA:I6Y1W3,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:I6Y1W3,NCBI_GP:CCP45658.1;Name=CCP45658.1;Note=Rv2857c%2C (MTV003.03c)%2C len: 258 aa. Probable short-chain dehydrogenase/reductase%2C highly similar to various dehydrogenases e.g. O88068|SCI35.33c probable dehydrogenase (SDR family) from Streptomyces coelicolor (260 aa)%2C FASTA scores: opt: 1208%2C E(): 2e-68%2C (72.35%25 identity in 253 aa overlap)%3B Q9I376|PA1649 from Pseudomonas aeruginosa probable short-chain dehydrogenase (253 aa)%2CFASTA scores: opt: 569%2C E(): 2.1e-28%2C (39.2%25 identity in 255 aa overlap)%3B Q9EX74|MLHA SDR-like enzyme from Rhodococcus erythropolis (246 aa)%2C FASTA scores: opt: 567%2CE(): 2.8e-28%2C (41.15%25 identity in 248 aa overlap)%3B etc. Also similar to many Mycobacterium tuberculosis dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c putative oxidoreductase (260 aa)%2C FASTA score: (38.3%25 identity in 248 aa overlap). Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2857c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP45658.1;transl_table=11
AL123456.3	EMBL	gene	3169356	3170723	.	-	.	ID=gene-Rv2858c;Name=aldC;gbkey=Gene;gene=aldC;gene_biotype=protein_coding;locus_tag=Rv2858c
AL123456.3	EMBL	CDS	3169356	3170723	.	-	0	ID=cds-CCP45659.1;Parent=gene-Rv2858c;Dbxref=EnsemblGenomes-Gn:Rv2858c,EnsemblGenomes-Tr:CCP45659,GOA:O33340,InterPro:IPR015590,InterPro:IPR016160,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR029510,UniProtKB/TrEMBL:O33340,NCBI_GP:CCP45659.1;Name=CCP45659.1;Note=Rv2858c%2C (MTV003.04c)%2C len: 455 aa. Probable aldC%2Caldehyde dehydrogenase%2C similar to many e.g. O88069|SCI35.34c putative aldehyde dehydrogenase from Streptomyces coelicolor (483 aa)%2C FASTA scores: opt: 1872%2CE(): 6.4e-109%2C (64.5%25 identity in 448 aa overlap)%3B Q9FAB1|ALDH|BT-ALDH aldehyde dehydrogenase from Bacillus thermoleovorans (497 aa)%2C FASTA scores: opt: 1157%2C E(): 2.1e-64%2C (44.3%25 identity in 458 aa overlap)%3B O33455|CYMC P-CUMIC aldehyde dehydrogenase from Pseudomonas putida (494 aa)%2C FASTA scores: opt: 1149%2C E(): 6.5e-64%2C (43.15%25 identity in 452 aa overlap)%3B P40047|DHA5_YEAST|ALD5|ALDH5|ALD3|YER073W aldehyde dehydrogenase from Saccharomyces cerevisiae (Baker's yeast) (519 aa)%2C FASTA scores: opt: 1091%2C E(): 2.7e-60%2C (38.55%25 identity in 459 aa overlap)%3B P80668|FEAB_ECOLI|PADA|MAOB|B1385 phenylacetaldehyde dehydrogenase from Escherichia coli strain K12 (499 aa)%2CFASTA scores: opt: 1074%2C E(): 3e-59%2C (42.2%25 identity in 462 aa overlap)%3B etc. Also similar to many M. tuberculosis dehydrogenases e.g. P71823|Rv0768|MTCY369.13 (489 aa)%2CFASTA score: (38.1%25 identity in 467 aa overlap). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site. Belongs to the aldehyde dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aldC;inference=protein motif:PROSITE:PS00687;locus_tag=Rv2858c;product=Probable aldehyde dehydrogenase AldC;protein_id=CCP45659.1;transl_table=11
AL123456.3	EMBL	gene	3170720	3171646	.	-	.	ID=gene-Rv2859c;Name=Rv2859c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2859c
AL123456.3	EMBL	CDS	3170720	3171646	.	-	0	ID=cds-CCP45660.1;Parent=gene-Rv2859c;Dbxref=EnsemblGenomes-Gn:Rv2859c,EnsemblGenomes-Tr:CCP45660,GOA:O33341,InterPro:IPR011697,InterPro:IPR017926,InterPro:IPR029062,NCBI_GP:CCP45660.1;Name=CCP45660.1;Note=Rv2859c%2C (MTV003.05c)%2C len: 308 aa. Possible amidotransferase%2C equivalent (but longer 58 aa) to Q9CBU9|ML1573 possible amidotransferase from Mycobacterium leprae (249 aa)%2C FASTA scores: opt: 1226%2C E(): 3e-64%2C(71.55%25 identity in 239 aa overlap). Also similar to other amidotransferases and hypothetical proteins%2C but shorter in N-terminus e.g. O88072|SCI35.37 hypothetical 25.3 KDA protein from Streptomyces coelicolor (242 aa)%2C FASTA scores: opt: 683%2C E(): 1.2e-32%2C (47.65%25 identity in 235 aa overlap)%3B AAK79730|Q97I88|CAC1764 predicted glutamine amidotransferase from Clostridium acetobutylicum (241 aa)%2CFASTA scores: opt: 458%2C E(): 1.6e-19%2C (32.95%25 identity in 246 aa overlap)%3B AAK75201|Q97QV9|SP1089 glutamine amidotransferase class I from Streptococcus pneumoniae (229 aa)%2C FASTA scores: opt: 431%2C E(): 5.6e-18%2C (34.75%25 identity in 236 aa overlap)%3B etc. Contains three 17 aa repeats at the N-terminus very similar to those in other Mycobacterium tuberculosis proteins e.g. Q10699|YY30_MYCTU|Rv2090|MT2151|MTCY49.30 putative 5'-3' exonuclease RV2090.;gbkey=CDS;locus_tag=Rv2859c;product=Possible amidotransferase;protein_id=CCP45660.1;transl_table=11
AL123456.3	EMBL	repeat_region	3171468	3171518	.	-	.	ID=id-Rv2859c;Note=51 bp direct repeat 1%2CGTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC;gbkey=repeat_region;locus_tag=Rv2859c
AL123456.3	EMBL	repeat_region	3171522	3171572	.	-	.	ID=id-Rv2859c-2;Note=51 bp direct repeat 2%2CGTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC;gbkey=repeat_region;locus_tag=Rv2859c
AL123456.3	EMBL	repeat_region	3171576	3171616	.	-	.	ID=id-Rv2859c-3;Note=(41 bp) part of 51 bp direct repeat 3%2CGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC;gbkey=repeat_region;locus_tag=Rv2859c
AL123456.3	EMBL	gene	3171627	3173000	.	-	.	ID=gene-Rv2860c;Name=glnA4;gbkey=Gene;gene=glnA4;gene_biotype=protein_coding;locus_tag=Rv2860c
AL123456.3	EMBL	CDS	3171627	3173000	.	-	0	ID=cds-CCP45661.1;Parent=gene-Rv2860c;Dbxref=EnsemblGenomes-Gn:Rv2860c,EnsemblGenomes-Tr:CCP45661,GOA:I6X5K1,InterPro:IPR008146,InterPro:IPR008147,InterPro:IPR014746,UniProtKB/TrEMBL:I6X5K1,NCBI_GP:CCP45661.1;Name=CCP45661.1;Note=Rv2860c%2C (MTV003.06c)%2C len: 457 aa. Probable glnA4%2Cglutamine synthetase class II%2C similar to many glutamine synthases e.g. O88070|SCI35.35c from Streptomyces coelicolor (462 aa)%2C FASTA scores: opt: 1947%2C E(): 8.2e-120%2C (64.15%25 identity in 452 aa overlap)%3B Q98H15|MLL3074 from Rhizobium loti (Mesorhizobium loti) (465 aa)%2C FASTA scores: opt: 1321%2C E(): 7.8e-79%2C (46.7%25 identity in 452 aa overlap)%3B Q98EM0|MLL4187 from Rhizobium loti (Mesorhizobium loti) (456 aa)%2C FASTA scores: opt: 698%2CE(): 4.6e-38%2C (33.5%25 identity in 454 aa overlap)%3B Q9CDL9|GLNA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (446 aa)%2C FASTA scores: opt: 633%2CE(): 8.2e-34%2C (32.45%25 identity in 456 aa overlap)%3B etc. Also similar to three other potential glutamine synthases in Mycobacterium tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427 .03c probable glutamine synthetase (446 aa)%2C FASTA score: (31.1%25 identity in 453 aa overlap)%3B Rv1878|glnA3 and Rv2220|glnA1. Belongs to the glutamine synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnA4;locus_tag=Rv2860c;product=Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II);protein_id=CCP45661.1;transl_table=11
AL123456.3	EMBL	gene	3173160	3174017	.	-	.	ID=gene-Rv2861c;Name=mapB;gbkey=Gene;gene=mapB;gene_biotype=protein_coding;gene_synonym=map;locus_tag=Rv2861c
AL123456.3	EMBL	CDS	3173160	3174017	.	-	0	ID=cds-CCP45662.1;Parent=gene-Rv2861c;Dbxref=EnsemblGenomes-Gn:Rv2861c,EnsemblGenomes-Tr:CCP45662,GOA:P9WK19,InterPro:IPR000994,InterPro:IPR001714,InterPro:IPR002467,PDB:1Y1N,PDB:1YJ3,PDB:3IU7,PDB:3IU8,PDB:3IU9,PDB:3PKA,PDB:3PKB,PDB:3PKC,PDB:3PKD,PDB:3PKE,PDB:3ROR,PDB:4IDY,PDB:4IEC,PDB:4IF7,NCBI_GP:CCP45662.1;Name=CCP45662.1;Note=Rv2861c%2C (MT2929%2C MTV003.07c)%2C len: 285 aa. mapB (alternate gene name: map)%2C methionine aminopeptidase%2Cequivalent to Q9CBU7|MAPB|ML1576 methionine aminopeptidase from Mycobacterium leprae (285 aa)%2C FASTA scores: opt: 1729%2C E(): 1e-99%2C (89.75%25 identity in 283 aa overlap). Also highly similar to many e.g. Q9RKR2|MAP3 from Streptomyces coelicolor (285 aa)%2C FASTA scores: opt: 1385%2C E(): 2e-78%2C(70.65%25 identity in 283 aa overlap)%3B Q9SW64|C7A10.320|AT4G37040 from Arabidopsis thaliana (Mouse-ear cress) (305 aa)%2C FASTA scores: opt: 914%2C E(): 3e-49%2C (50.35%25 identity in 286 aa overlap)%3B P07906|AMPM_ECOLI|map|B0168|Z0178|ECS0170 from Escherichia coli strains K12 and O157:H7 (264 aa)%2C FASTA scores: opt: 793%2C E(): 8.5e-42%2C (51.0%25 identity in 245 aa overlap)%3B etc. Belongs to peptidase family M24A%3B also known as the map family 1. Cofactor: cobalt%3B binds 2 ions per subunit. Note that this gene has an N-terminal extension present in the human map%2C but not in the prokaryotic map's. An alternative start%2C with RBS%2C will give a protein equivalent to the shorter prokaryotic map's. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mapB;locus_tag=Rv2861c;product=Methionine aminopeptidase MapB (map) (peptidase M);protein_id=CCP45662.1;transl_table=11
AL123456.3	EMBL	gene	3174059	3174643	.	-	.	ID=gene-Rv2862c;Name=Rv2862c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2862c
AL123456.3	EMBL	CDS	3174059	3174643	.	-	0	ID=cds-CCP45663.1;Parent=gene-Rv2862c;Dbxref=EnsemblGenomes-Gn:Rv2862c,EnsemblGenomes-Tr:CCP45663,InterPro:IPR012551,UniProtKB/TrEMBL:I6Y1W7,NCBI_GP:CCP45663.1;Name=CCP45663.1;Note=Rv2862c%2C (MTV003.08)%2C len: 194 aa. Conserved hypothetical protein%2C showing some similarity with others e.g. Q9X8X5|SCH35.31c hypothetical 19.6 KDA protein from Streptomyces coelicolor (180 aa)%2C FASTA scores: opt: 266%2CE(): 2.2e-11%2C (34.65%25 identity in 179 aa overlap)%3B Q9Z5H1|ML0169|MLCB373.19 hypothetical 22.1 KDA protein from Mycobacterium leprae (200 aa)%2C FASTA scores: opt: 195%2C E(): 2.3e-06%2C (30.15%25 identity in 189 aa overlap)%3B etc. Also some similarity to P71544|Y966_MYCTU|Rv0966c|MT0994|MTCY10D7.08 conserved hypothetical protein from Mycobacterium tuberculosis (230 aa)%2C FASTA scores: opt: 209%2C E(): 2.6e-07%2C (31.5%25 identity in 184 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2862c;product=Conserved hypothetical protein;protein_id=CCP45663.1;transl_table=11
AL123456.3	EMBL	gene	3174747	3174995	.	+	.	ID=gene-Rv2862A;Name=vapB23;gbkey=Gene;gene=vapB23;gene_biotype=protein_coding;locus_tag=Rv2862A
AL123456.3	EMBL	CDS	3174747	3174995	.	+	0	ID=cds-CCP45664.1;Parent=gene-Rv2862A;Dbxref=EnsemblGenomes-Gn:Rv2862A,EnsemblGenomes-Tr:CCP45664,NCBI_GP:CCP45664.1;Name=CCP45664.1;Note=Rv2862A%2C len: 82 aa. Possible vapB23%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv2863 (See Pandey and Gerdes%2C 2005).;gbkey=CDS;gene=vapB23;locus_tag=Rv2862A;product=Possible antitoxin VapB23;protein_id=CCP45664.1;transl_table=11
AL123456.3	EMBL	gene	3174992	3175372	.	+	.	ID=gene-Rv2863;Name=vapC23;gbkey=Gene;gene=vapC23;gene_biotype=protein_coding;locus_tag=Rv2863
AL123456.3	EMBL	CDS	3174992	3175372	.	+	0	ID=cds-CCP45665.1;Parent=gene-Rv2863;Dbxref=EnsemblGenomes-Gn:Rv2863,EnsemblGenomes-Tr:CCP45665,GOA:P9WF89,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45665.1;Name=CCP45665.1;Note=Rv2863%2C (MTV003.09)%2C len: 126 aa. Possible vapC23%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2862A%2Ccontains PIN domain (See Arcus et al.%2C 2005%3B Pandey and Gerdes%2C 2005). Similar to others in Mycobacterium tuberculosis e.g. Q50595|YI38_MYCTU|Rv1838c|MT1886|MTCY1A11.05|MTCY359.35 conserved hypothetical protein (131 aa)%2C FASTA scores: opt: 299%2C E(): 6.5e-15%2C (39.0%25 identity in 123 aa overlap).;gbkey=CDS;gene=vapC23;locus_tag=Rv2863;product=Possible toxin VapC23;protein_id=CCP45665.1;transl_table=11
AL123456.3	EMBL	gene	3175454	3177265	.	-	.	ID=gene-Rv2864c;Name=Rv2864c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2864c
AL123456.3	EMBL	CDS	3175454	3177265	.	-	0	ID=cds-CCP45666.1;Parent=gene-Rv2864c;Dbxref=EnsemblGenomes-Gn:Rv2864c,EnsemblGenomes-Tr:CCP45666,GOA:O33346,InterPro:IPR001460,InterPro:IPR007887,InterPro:IPR012338,UniProtKB/TrEMBL:O33346,NCBI_GP:CCP45666.1;Name=CCP45666.1;Note=Rv2864c%2C (MTV003.10c)%2C len: 603 aa. Possible penicillin-binding lipoprotein%2C probably located in periplasm%2C equivalent to Q9CBU6|ML1577 probable penicillin binding protein from Mycobacterium leprae (608 aa)%2C FASTA scores: opt: 3352%2C E(): 2.1e-193%2C (81.5%25 identity in 606 aa overlap). Also shows some similarity to others e.g. P72405|PCBR from Streptomyces clavuligerus (551 aa)%2C FASTA scores: opt: 543%2C E(): 6.1e-25%2C (28.4%25 identity in 567 aa overlap)%3B Q9F2L0|SCH63.18c from Streptomyces coelicolor (546 aa)%2C FASTA scores: opt: 519%2C E(): 1.7e-23%2C (29.3%25 identity in 577 aa overlap)%3B Q9RKD1|SCE87.07 from Streptomyces coelicolor (541 aa)%2C FASTA scores: opt: 472%2CE(): 1.1e-20%2C (34.3%25 identity in 318 aa overlap)%3B etc. Equivalent to AAK47258 from Mycobacterium tuberculosis strain CDC1551 (618 aa) but shorter 15 aa. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C and PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2864c;product=Possible penicillin-binding lipoprotein;protein_id=CCP45666.1;transl_table=11
AL123456.3	EMBL	gene	3177537	3177818	.	+	.	ID=gene-Rv2865;Name=relF;gbkey=Gene;gene=relF;gene_biotype=protein_coding;gene_synonym=relB2;locus_tag=Rv2865
AL123456.3	EMBL	CDS	3177537	3177818	.	+	0	ID=cds-CCP45667.1;Parent=gene-Rv2865;Dbxref=EnsemblGenomes-Gn:Rv2865,EnsemblGenomes-Tr:CCP45667,GOA:O33347,InterPro:IPR006442,PDB:3G5O,NCBI_GP:CCP45667.1;Name=CCP45667.1;Note=Rv2865%2C (MTV003.11)%2C len: 93 aa. RelF%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv2866 (See Pandey and Gerdes%2C 2005)%2C showing weak similarity with P58235|YR54_SYNY3|SSR2754 hypothetical 9.7 KDA protein from Synechocystis sp. strain PCC 6803 (87 aa)%2C FASTA scores: opt: 134%2C E(): 0.007%2C (30.65%25 identity in 75 aa overlap)%3B BAB58570|SAV2408 conserved hypothetical protein from Staphylococcus aureus subsp. aureus Mu50 (83 aa)%2C FASTA scores: opt: 124%2C E(): 0.037%2C (27.5%25 identity in 80 aa overlap). Also similar to Rv1247|MTV006.19c hypothetical 9.8 KDA protein from Mycobacterium tuberculosis (89 aa)%2CFASTA scores: opt: 249%2C E(): 2.6e-11%2C (44.2%25 identity in 86 aa overlap).;gbkey=CDS;gene=relF;locus_tag=Rv2865;product=Antitoxin RelF;protein_id=CCP45667.1;transl_table=11
AL123456.3	EMBL	gene	3177822	3178085	.	+	.	ID=gene-Rv2866;Name=relG;gbkey=Gene;gene=relG;gene_biotype=protein_coding;gene_synonym=relE2;locus_tag=Rv2866
AL123456.3	EMBL	CDS	3177822	3178085	.	+	0	ID=cds-CCP45668.1;Parent=gene-Rv2866;Dbxref=EnsemblGenomes-Gn:Rv2866,EnsemblGenomes-Tr:CCP45668,GOA:O33348,InterPro:IPR007712,PDB:3G5O,NCBI_GP:CCP45668.1;Name=CCP45668.1;Note=Rv2866%2C (MTV003.12)%2C len: 87 aa. RelG%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv2865 (See Pandey and Gerdes%2C 2005)%2C similar to O50461|Rv1246c|MTV006.18c conserved hypothetical protein from Mycobacterium tuberculosis (97 aa)%2C FASTA scores: opt: 290%2C E(): 3.6e-16%2C(54.1%25 identity in 85 aa overlap).;gbkey=CDS;gene=relG;locus_tag=Rv2866;product=Toxin RelG;protein_id=CCP45668.1;transl_table=11
AL123456.3	EMBL	gene	3178458	3179312	.	-	.	ID=gene-Rv2867c;Name=Rv2867c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2867c
AL123456.3	EMBL	CDS	3178458	3179312	.	-	0	ID=cds-CCP45669.1;Parent=gene-Rv2867c;Dbxref=EnsemblGenomes-Gn:Rv2867c,EnsemblGenomes-Tr:CCP45669,GOA:I6XFI7,InterPro:IPR000182,InterPro:IPR013653,InterPro:IPR016181,InterPro:IPR016794,InterPro:IPR025289,UniProtKB/TrEMBL:I6XFI7,NCBI_GP:CCP45669.1;Name=CCP45669.1;Note=Rv2867c%2C (MTV003.13c)%2C len: 284 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005. Similar to others e.g. Q9KYR8|SC5H4.21 hypothetical 31.3 KDA protein from Streptomyces coelicolor (287 aa)%2C FASTA scores: opt: 798%2C E(): 2.4e-45%2C (47.95%25 identity in 269 aa overlap).;gbkey=CDS;locus_tag=Rv2867c;product=GCN5-related N-acetyltransferase;protein_id=CCP45669.1;transl_table=11
AL123456.3	EMBL	gene	3179368	3180531	.	-	.	ID=gene-Rv2868c;Name=gcpE;gbkey=Gene;gene=gcpE;gene_biotype=protein_coding;locus_tag=Rv2868c
AL123456.3	EMBL	CDS	3179368	3180531	.	-	0	ID=cds-CCP45670.1;Parent=gene-Rv2868c;Dbxref=EnsemblGenomes-Gn:Rv2868c,EnsemblGenomes-Tr:CCP45670,GOA:P9WKG3,InterPro:IPR004588,InterPro:IPR011005,InterPro:IPR013785,InterPro:IPR016425,NCBI_GP:CCP45670.1;Name=CCP45670.1;Note=Rv2868c%2C (MTV003.14c)%2C len: 387 aa. Probable gcpE protein (protein e)%2C equivalent to Q9CBU5|GCPE|ML1581 hypothetical protein GCPE from Mycobacterium leprae (392 aa)%2C FASTA scores: opt: 2247%2C E(): 6.8e-134%2C (87.65%25 identity in 388 aa overlap). Highly similar to essential gene of unknown function from Escherichia coli and other prokaryotes e.g. Q9X7W2|GCPE_STRCO|SC6A5.16 GCPE protein homolog from Streptomyces coelicolor (384 aa)%2C FASTA scores: opt: 1965%2C E(): 3.8e-116%2C (78.2%25 identity in 385 aa overlap)%3B P54482|GCPE_BACSU GCPE protein homolog from Bacillus subtilis (377 aa)%2C FASTA scores: opt: 1157%2C E(): 2.6e-65%2C (49.55%25 identity in 351 aa overlap)%3B P27433|GCPE_ECOLI|B2515|Z3778|ECS3377 GCPE protein (protein E) from Escherichia coli strains K12 and O157:H7 (372 aa)%2CFASTA scores: opt: 984%2C E(): 2e-54%2C (44.15%25 identity in 360 aa overlap)%3B etc. Belongs to the GCPE family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gcpE;locus_tag=Rv2868c;product=Probable GcpE protein;protein_id=CCP45670.1;transl_table=11
AL123456.3	EMBL	gene	3180548	3181762	.	-	.	ID=gene-Rv2869c;Name=rip;gbkey=Gene;gene=rip;gene_biotype=protein_coding;locus_tag=Rv2869c
AL123456.3	EMBL	CDS	3180548	3181762	.	-	0	ID=cds-CCP45671.1;Parent=gene-Rv2869c;Dbxref=EnsemblGenomes-Gn:Rv2869c,EnsemblGenomes-Tr:CCP45671,GOA:P9WHS3,InterPro:IPR001478,InterPro:IPR008915,NCBI_GP:CCP45671.1;Name=CCP45671.1;Note=Rv2869c%2C (MTV003.15c)%2C len: 404 aa. Rip%2Cmetalloprotease%2C regulates intramembrane proteolysis and controls membrane composition (rip%2C see Makinoshima and Glickman%2C 2005). Similar to site two protease (S2P) in higher eukaryotes. Conserved transmembrane protein%2Cequivalent to Q9CBU4|ML1582 probable integral membrane protein from Mycobacterium leprae (404 aa)%2C FASTA scores: opt: 2250%2C E(): 1.1e-128%2C (82.2%25 identity in 404 aa overlap). Also weakly similar to other membrane proteins or hypothetical proteins e.g. Q9A710|CC1916 putative membrane-associated zinc metalloprotease from Caulobacter crescentus (398 aa)%2C FASTA scores: opt: 368%2C E(): 7.8e-15%2C(28.1%25 identity in 427 aa overlap). Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007). Cleaves PbpB|Rv2163c in a Zn2+ -dependent manner (See Mukherjee et al.%2C 2009). Cleaves proteins RskA|Rv0444c%2C RslA|Rv0736%2C and Rv3912%2C in M. tuberculosis Erdman (See Sklar et al.%2C 2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rip;locus_tag=Rv2869c;product=Membrane bound metalloprotease;protein_id=CCP45671.1;transl_table=11
AL123456.3	EMBL	gene	3181770	3183011	.	-	.	ID=gene-Rv2870c;Name=dxr;gbkey=Gene;gene=dxr;gene_biotype=protein_coding;gene_synonym=ispC;locus_tag=Rv2870c
AL123456.3	EMBL	CDS	3181770	3183011	.	-	0	ID=cds-CCP45672.1;Parent=gene-Rv2870c;Dbxref=EnsemblGenomes-Gn:Rv2870c,EnsemblGenomes-Tr:CCP45672,GOA:P9WNS1,InterPro:IPR003821,InterPro:IPR013512,InterPro:IPR013644,InterPro:IPR016040,InterPro:IPR026877,PDB:2C82,PDB:2JCV,PDB:2JCX,PDB:2JCY,PDB:2JD0,PDB:2JD1,PDB:2JD2,PDB:2Y1C,PDB:2Y1D,PDB:2Y1E,PDB:2Y1F,PDB:2Y1G,PDB:3RAS,PDB:3ZHX,PDB:3ZHY,PDB:3ZHZ,PDB:3ZI0,PDB:4A03,PDB:4AIC,PDB:4OOE,PDB:4OOF,NCBI_GP:CCP45672.1;Name=CCP45672.1;Note=Rv2870c%2C (MTCY274.01c%2C MTV003.16c)%2C len: 413 aa. Probable dxr%2C 1-deoxy-D-xylulose 5-phosphate reductoisomerase%2C equivalent to Q9CBU3|DXR|ML1583 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Mycobacterium leprae (406 aa)%2C FASTA scores: opt: 2145%2CE(): 1e-124%2C (84.05%25 identity in 395 aa overlap). Also highly similar to others e.g. Q9AJD7|DXR from Kitasatospora griseola (Streptomyces griseolosporeus) (386 aa)%2C FASTA scores: opt: 1176%2C E(): 5.2e-65%2C (56.45%25 identity in 388 aa overlap)%3B Q9KYS1|DXR_STRCO|SC5H4.18 from Streptomyces coelicolor (401 aa)%2C FASTA scores: opt: 1079%2C E(): 5.1e-59%2C(52.25%25 identity in 396 aa overlap)%3B P45568|DXR|B0173 from Escherichia coli strain K12 (398 aa)%2C FASTA scores: opt: 120%2C E(): 0.032%2C (52.9%25 identity in 34 aa overlap)%3B etc. Contains PS00133 Zinc carboxypeptidases%2C zinc-binding region 2 signature. Belongs to the DXR family. N-terminus shortened since first submission.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dxr;inference=protein motif:PROSITE:PS00133;locus_tag=Rv2870c;product=Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase);protein_id=CCP45672.1;transl_table=11
AL123456.3	EMBL	repeat_region	3181794	3181836	.	+	.	ID=id-AL123456.3:3181794..3181836;Note=(43 bp) part of 51 bp direct repeat%2CGTGTCGACCCGCTGCGCCCGGCTTCGCCGTGCTTGCGATCGCC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3183138	3183395	.	+	.	ID=gene-Rv2871;Name=vapB43;gbkey=Gene;gene=vapB43;gene_biotype=protein_coding;locus_tag=Rv2871
AL123456.3	EMBL	CDS	3183138	3183395	.	+	0	ID=cds-CCP45673.1;Parent=gene-Rv2871;Dbxref=EnsemblGenomes-Gn:Rv2871,EnsemblGenomes-Tr:CCP45673,GOA:P9WL41,InterPro:IPR002145,InterPro:IPR010985,InterPro:IPR013321,NCBI_GP:CCP45673.1;Name=CCP45673.1;Note=Rv2871%2C (MTCY274.02)%2C len: 85 aa. Possible vapB43%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv2872%2Csee Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50456|Rv1241|MTV006.13 (86 aa)%2C FASTA scores: opt: 172%2CE(): 2.9e-05%2C (37.2%25 identity in 86 aa overlap)%3B O53811|Rv0748|MTV041.22 (85 aa)%2C FASTA scores: opt: 170%2CE(): 4e-05%2C (35.3%25 identity in 85 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB43;locus_tag=Rv2871;product=Possible antitoxin VapB43;protein_id=CCP45673.1;transl_table=11
AL123456.3	EMBL	gene	3183382	3183825	.	+	.	ID=gene-Rv2872;Name=vapC43;gbkey=Gene;gene=vapC43;gene_biotype=protein_coding;locus_tag=Rv2872
AL123456.3	EMBL	CDS	3183382	3183825	.	+	0	ID=cds-CCP45674.1;Parent=gene-Rv2872;Dbxref=EnsemblGenomes-Gn:Rv2872,EnsemblGenomes-Tr:CCP45674,GOA:P9WF55,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45674.1;Name=CCP45674.1;Note=Rv2872%2C (MTCY274.03)%2C len: 147 aa. Possible vapC43%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv2871%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53683|Rv0277c|MTV035.05c (142 aa)%2C FASTA scores: opt: 357%2C E(): 1.4e-17%2C (41.45%25 identity in 140 aa overlap)%3B O53812|Rv0749|MTV041.23 (142 aa)%2C FASTA scores: opt: 350%2C E(): 4.3e-17%2C (41.55%25 identity in 142 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC43;locus_tag=Rv2872;product=Possible toxin VapC43. Contains PIN domain.;protein_id=CCP45674.1;transl_table=11
AL123456.3	EMBL	gene	3183905	3184567	.	+	.	ID=gene-Rv2873;Name=mpt83;gbkey=Gene;gene=mpt83;gene_biotype=protein_coding;gene_synonym=mpb83;locus_tag=Rv2873
AL123456.3	EMBL	CDS	3183905	3184567	.	+	0	ID=cds-CCP45675.1;Parent=gene-Rv2873;Dbxref=EnsemblGenomes-Gn:Rv2873,EnsemblGenomes-Tr:CCP45675,GOA:P9WNF3,InterPro:IPR000782,NCBI_GP:CCP45675.1;Name=CCP45675.1;Note=Rv2873%2C (MTCY274.04)%2C len: 220 aa. Mpt83 (alternate gene name: mpb83)%2C cell surface lipoprotein (see citations below). Also similar to upstream ORF Q50769|MP70_MYCTU|MPT70|MPB70|Rv2875|MT2943|MTCY274.06 which is also known as major secreted immunogenic protein MPT70 precursor from Mycobacterium tuberculosis (193 aa)%2CFASTA scores: opt: 806%2C E(): 2.7e-38%2C (70.25%25 identity in 185 aa overlap). Belongs to the MPT70 / MPT83 family. Attached to the membrane by a lipid anchor.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mpt83;locus_tag=Rv2873;product=Cell surface lipoprotein Mpt83 (lipoprotein P23);protein_id=CCP45675.1;transl_table=11
AL123456.3	EMBL	gene	3184847	3186934	.	+	.	ID=gene-Rv2874;Name=dipZ;gbkey=Gene;gene=dipZ;gene_biotype=protein_coding;locus_tag=Rv2874
AL123456.3	EMBL	CDS	3184847	3186934	.	+	0	ID=cds-CCP45676.1;Parent=gene-Rv2874;Dbxref=EnsemblGenomes-Gn:Rv2874,EnsemblGenomes-Tr:CCP45676,GOA:P9WG63,InterPro:IPR000866,InterPro:IPR003834,InterPro:IPR008979,InterPro:IPR012336,PDB:2HYX,NCBI_GP:CCP45676.1;Name=CCP45676.1;Note=Rv2874%2C (MT2942%2C MTCY274.05)%2C len: 695 aa. Possible dipZ%2C cytochrome c-type biogenesis protein (see citation below)%2C probable integral membrane protein%2C similar in part to others or hypothetical proteins e.g. CAC48606|SMB20213 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (627 aa)%2C FASTA scores: opt: 844%2CE(): 7.3e-43%2C (32.65%25 identity in 643 aa overlap)%3B Q9ZMH0|CCDA or JHP0250 putative cytochrome C-type biogenesis protein from Helicobacter pylori J99 (Campylobacter pylori J99) (239 aa)%2C FASTA scores: opt: 250%2C E(): 1.4e-07%2C (27.3%25 identity in 227 aa overlap)%3B Q9LA04|CCDA C-type cytochrome biogenesis protein from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (252 aa)%2C FASTA scores: opt: 245%2C E(): 2.9e-07%2C (27.85%25 identity in 244 aa overlap)%3B etc. Also similar to O06393|CCSA|Rv0527|MTCY25D10.06 cytochrome C-type biogenesis protein from Mycobacterium tuberculosis (259 aa)%2C FASTA scores: opt: 280%2C E(): 2.4e-09%2C (29.3%25 identity in 239 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dipZ;locus_tag=Rv2874;product=Possible integral membrane C-type cytochrome biogenesis protein DipZ;protein_id=CCP45676.1;transl_table=11
AL123456.3	EMBL	gene	3187030	3187611	.	+	.	ID=gene-Rv2875;Name=mpt70;gbkey=Gene;gene=mpt70;gene_biotype=protein_coding;gene_synonym=mpb70;locus_tag=Rv2875
AL123456.3	EMBL	CDS	3187030	3187611	.	+	0	ID=cds-CCP45677.1;Parent=gene-Rv2875;Dbxref=EnsemblGenomes-Gn:Rv2875,EnsemblGenomes-Tr:CCP45677,GOA:P9WNF5,InterPro:IPR000782,PDB:1NYO,NCBI_GP:CCP45677.1;Name=CCP45677.1;Note=Rv2875%2C (MTCY274.06)%2C len: 193 aa. Mpt70 (alternate gene name: mpb70)%2C major secreted immunogenic protein MPT70 precursor (see citations below). Also similar to downstream ORF Q10790|MP83_MYCTU|MPT83|MPB83|Rv2873|MT2940|MTCY274.04 cell surface lipoprotein MPT83 precursor (lipoprotein P23) (220 aa)%2C FASTA scores: opt: 806%2C E(): 1.2e-40%2C (70.25%25 identity in 185 aa overlap). Belongs to the MPT70 / MPT83 family. Generally found as a monomer%3B homodimer in culture fluids.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mpt70;locus_tag=Rv2875;product=Major secreted immunogenic protein Mpt70;protein_id=CCP45677.1;transl_table=11
AL123456.3	EMBL	gene	3187663	3187977	.	+	.	ID=gene-Rv2876;Name=Rv2876;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2876
AL123456.3	EMBL	CDS	3187663	3187977	.	+	0	ID=cds-CCP45678.1;Parent=gene-Rv2876;Dbxref=EnsemblGenomes-Gn:Rv2876,EnsemblGenomes-Tr:CCP45678,GOA:P9WL39,InterPro:IPR024341,NCBI_GP:CCP45678.1;Name=CCP45678.1;Note=Rv2876%2C (MTCY274.07)%2C len: 104 aa. Possible conserved transmembrane protein%2C equivalent (but longer 16 aa) to Q9CBU2|ML1584 possible conserved membrane protein from Mycobacterium leprae (84 aa)%2C FASTA scores: opt: 444%2CE(): 8.3e-26%2C (73.85%25 identity in 88 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2876;product=Possible conserved transmembrane protein;protein_id=CCP45678.1;transl_table=11
AL123456.3	EMBL	gene	3188008	3188871	.	-	.	ID=gene-Rv2877c;Name=Rv2877c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2877c
AL123456.3	EMBL	CDS	3188008	3188871	.	-	0	ID=cds-CCP45679.1;Parent=gene-Rv2877c;Dbxref=EnsemblGenomes-Gn:Rv2877c,EnsemblGenomes-Tr:CCP45679,GOA:I6YEL8,InterPro:IPR003834,UniProtKB/TrEMBL:I6YEL8,NCBI_GP:CCP45679.1;Name=CCP45679.1;Note=Rv2877c%2C (MTCY274.08c)%2C len: 287 aa. Probable conserved integral membrane protein%2C Mer family possibly involved in transport of mercury%2C similar to others%2C and to the fourth protein of the mercury resistance operon of Streptomyces sp (or other organisms)%2C and to putative cytochrome-c biogenesis proteins e.g. Q9XBD1|CZA382.20C putative integral membrane transporter from Amycolatopsis orientalis (298 aa)%2C FASTA scores: opt: 913%2C E(): 7.6e-46%2C(51.55%25 identity in 293 aa overlap)%3B P30344|MER4_STRLI mercury resistance probable HG transport protein from Streptomyces lividans (319 aa)%2C FASTA scores: opt: 427%2CE(): 1.2e-17%2C (32.85%25 identity in 289 aa overlap)%3B Q9M5P3 putative cytochrome C biogenesis protein precursor from Arabidopsis thaliana (Mouse-ear cress) (354 aa)%2C FASTA scores: opt: 229%2C E(): 4e-06%2C (29.85%25 identity in 221 aa overlap)%3B etc. Contains PS00044 Bacterial regulatory proteins%2C lysR family signature. Note that previously known as merT.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv2877c;product=Probable conserved integral membrane protein;protein_id=CCP45679.1;transl_table=11
AL123456.3	EMBL	gene	3188876	3189397	.	-	.	ID=gene-Rv2878c;Name=mpt53;gbkey=Gene;gene=mpt53;gene_biotype=protein_coding;gene_synonym=dsbE;locus_tag=Rv2878c
AL123456.3	EMBL	CDS	3188876	3189397	.	-	0	ID=cds-CCP45680.1;Parent=gene-Rv2878c;Dbxref=EnsemblGenomes-Gn:Rv2878c,EnsemblGenomes-Tr:CCP45680,GOA:P9WG65,InterPro:IPR012336,InterPro:IPR013740,PDB:1LU4,NCBI_GP:CCP45680.1;Name=CCP45680.1;Note=Rv2878c%2C (MT2946%2C MTCY274.09c)%2C len: 173 aa. Mpt53%2Csecreted protein (contains N-terminal signal sequence) (see citations below). Shows some similarity with several disulfide bond interchange proteins e.g. P43787|THIX_HAEIN thioredoxin-like protein HI1115 from Haemophilus influenzae (167 aa)%2C FASTA scores: opt: 200%2C E(): 1.4e-06%2C (28.9%25 identity in 135 aa overlap)%3B P52237|TIPB_PSEFL thiol:disulfide interchange protein TIPB precursor (cytochrome C biogenesis protein TIPB) (178 aa)%2C FASTA scores: opt: 184%2C E(): 1.8e-05%2C (26.3%25 identity in 171 aa overlap)%3B etc. Also highly similar to O53924|DSBF|Rv1677|MTV047.12 putative lipoprotein from Mycobacterium tuberculosis (182 aa)%2C FASTA scores: opt: 482%2C E(): 5.7e-26%2C (52.8%25 identity in 142 aa overlap). Could be belong to the thioredoxin family. Note that also previously known as dsbE.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mpt53;locus_tag=Rv2878c;product=Soluble secreted antigen Mpt53 precursor;protein_id=CCP45680.1;transl_table=11
AL123456.3	EMBL	gene	3189583	3190152	.	-	.	ID=gene-Rv2879c;Name=Rv2879c;end_range=3190152,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2879c;partial=true
AL123456.3	EMBL	CDS	3189583	3190152	.	-	0	ID=cds-CCP45681.1;Parent=gene-Rv2879c;Dbxref=EnsemblGenomes-Gn:Rv2879c,EnsemblGenomes-Tr:CCP45681,GOA:P9WH15,InterPro:IPR004383,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR013785,InterPro:IPR027492,NCBI_GP:CCP45681.1;Name=CCP45681.1;Note=Rv2879c%2C (MTCY274.10c)%2C len: 189 aa. Conserved hypothetical protein%2C similar to others e.g. C-terminus of Q9RVT6|DR0936 conserved hypothetical protein from Deinococcus radiodurans (346 aa)%2C FASTA scores: opt: 505%2CE(): 1e-26%2C (46.5%25 identity in 185 aa overlap)%3B O34617|YLON_BACSU hypothetical 41.6 KDA protein from Bacillus subtilis (363 aa)%2C FASTA scores: opt: 459%2C E(): 1.2e-24%2C (40.5%25 identity in 185 aa overlap)%3B YFGB_ECOLI|P36979 hypothetical 43.1 kDa protein from Escherichia coli (384 aa)%2C FASTA scores%2C opt: 410%2C E(): 2.8e-21%2C (41.7%25 identity in 187 aa overlap)%3B etc. Appears to be a frame shift with respect to following ORF but we can detect no error in the cosmid sequence to account for this.;end_range=3190152,.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2879c;partial=true;product=Conserved hypothetical protein;protein_id=CCP45681.1;transl_table=11
AL123456.3	EMBL	gene	3189851	3190678	.	-	.	ID=gene-Rv2880c;Name=Rv2880c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2880c
AL123456.3	EMBL	CDS	3189851	3190678	.	-	0	ID=cds-CCP45682.1;Parent=gene-Rv2880c;Dbxref=EnsemblGenomes-Gn:Rv2880c,EnsemblGenomes-Tr:CCP45682,GOA:P9WH15,InterPro:IPR004383,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR013785,InterPro:IPR027492,NCBI_GP:CCP45682.1;Name=CCP45682.1;Note=Rv2880c%2C (MTCY274.11c)%2C len: 275 aa. Conserved hypothetical protein%2C highly similar in N-terminus to others e.g. O86754|SC6A9.22c hypothetical 40.4 KDA protein from Streptomyces coelicolor (368 aa)%2C FASTA scores: opt: 663%2C E(): 2.6e-33%2C (52.6%25 identity in 213 aa overlap)%3B Q55880|Y098_SYNY3|SLL0098 hypothetical 38.9 KDA protein from Synechocystis sp. strain PCC 6803 (350 aa)%2C FASTA scores: opt: 362%2C E(): 7.3e-15%2C (38.9%25 identity in 162 aa overlap)%3B O66732|AQ_416 hypothetical 40.2 KDA protein from Aquifex aeolicus (348 aa)%2C FASTA scores: opt: 321%2C E(): 2.4e-12%2C (39.75%25 identity in 146 aa overlap)%3B etc. Appears to be a frame shift with respect to preceding ORF but we can detect no error in the cosmid sequence to account for this.;gbkey=CDS;locus_tag=Rv2880c;product=Conserved hypothetical protein;protein_id=CCP45682.1;transl_table=11
AL123456.3	EMBL	gene	3190701	3191621	.	-	.	ID=gene-Rv2881c;Name=cdsA;gbkey=Gene;gene=cdsA;gene_biotype=protein_coding;locus_tag=Rv2881c
AL123456.3	EMBL	CDS	3190701	3191621	.	-	0	ID=cds-CCP45683.1;Parent=gene-Rv2881c;Dbxref=EnsemblGenomes-Gn:Rv2881c,EnsemblGenomes-Tr:CCP45683,GOA:P9WPF7,InterPro:IPR000374,NCBI_GP:CCP45683.1;Name=CCP45683.1;Note=Rv2881c%2C (MTCY274.12c)%2C len: 306 aa. Probable cdsA%2Cphosphatidate cytidylyltransferase%2C integral membrane protein%2C equivalent to Q9CBU1|CDSA_MYCLE|ML1589 phosphatidate cytidylyltransferase from Mycobacterium leprae (312 aa)%2C FASTA scores: opt: 1470%2C E(): 1.1e-84%2C(70.3%25 identity in 313 aa overlap). Also similar to others e.g. Q9KPV7|VC2255 from Vibrio cholerae (280 aa)%2C FASTA scores: opt: 383%2C E(): 1.1e-16%2C (29.3%25 identity in 280 aa overlap)%3B Q9CDT2|CDSA from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (267 aa)%2C FASTA scores: opt: 361%2C E(): 2.6e-15%2C (29.05%25 identity in 265 aa overlap)%3B P06466|CDSA_ECOLI|CDS|B0175|Z0186|ECS0177 from Escherichia coli strains K12 and O157:H7 (249 aa)%2C FASTA scores: opt: 352%2C E(): 9.2e-15%2C (40.4%25 identity in 156 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the CDS family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cdsA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2881c;product=Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase);protein_id=CCP45683.1;transl_table=11
AL123456.3	EMBL	gene	3191644	3192201	.	-	.	ID=gene-Rv2882c;Name=frr;gbkey=Gene;gene=frr;gene_biotype=protein_coding;locus_tag=Rv2882c
AL123456.3	EMBL	CDS	3191644	3192201	.	-	0	ID=cds-CCP45684.1;Parent=gene-Rv2882c;Dbxref=EnsemblGenomes-Gn:Rv2882c,EnsemblGenomes-Tr:CCP45684,GOA:P9WGY1,InterPro:IPR002661,InterPro:IPR023584,PDB:1WQF,PDB:1WQG,PDB:1WQH,PDB:4KAW,PDB:4KB2,PDB:4KB4,PDB:4KC6,PDB:4KDD,NCBI_GP:CCP45684.1;Name=CCP45684.1;Note=Rv2882c%2C (MTCY274.13c)%2C len: 185 aa. Probable frr%2Cribosome recycling factor%2C equivalent to O33046|RRF_MYCLE|FRR|ML1590|MLCB250.76 ribosome recycling factor from Mycobacterium leprae (185 aa)%2C FASTA scores: opt: 1063%2C E(): 2.6e-60%2C (90.8%25 identity in 185 aa overlap). Also highly similar to others e.g. O86770|RRF_STRCO|FRR|SC6A9.40c from Streptomyces coelicolor (185 aa)%2C FASTA scores: opt: 783%2C E(): 1.5e-42%2C (63.25%25 identity in 185 aa overlap)%3B P81101|RRF_BACSU|FRR from Bacillus subtilis (184 aa)%2C FASTA scores: opt: 640%2C E(): 1.7e-33%2C (51.65%25 identity in 182 aa overlap)%3B P16174|RRF_ECOLI|FRR|B0172|Z0183|ECS0174 from Escherichia coli strains K12 and O157:H7 (185 aa)%2C FASTA scores: opt: 473%2C E(): 1.4e-23%2C (40.2%25 identity in 184 aa overlap)%3B etc. Belongs to the RRF family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=frr;locus_tag=Rv2882c;product=Ribosome recycling factor Frr (ribosome releasing factor) (RRF);protein_id=CCP45684.1;transl_table=11
AL123456.3	EMBL	repeat_region	3192202	3192254	.	-	.	ID=id-AL123456.3:3192202..3192254;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3192255	3192307	.	-	.	ID=id-AL123456.3:3192255..3192307;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3192308	3192360	.	-	.	ID=id-AL123456.3:3192308..3192360;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	3192373	3193158	.	-	.	ID=gene-Rv2883c;Name=pyrH;gbkey=Gene;gene=pyrH;gene_biotype=protein_coding;locus_tag=Rv2883c
AL123456.3	EMBL	CDS	3192373	3193158	.	-	0	ID=cds-CCP45685.1;Parent=gene-Rv2883c;Dbxref=EnsemblGenomes-Gn:Rv2883c,EnsemblGenomes-Tr:CCP45685,GOA:P9WHK5,InterPro:IPR001048,InterPro:IPR011817,InterPro:IPR015963,PDB:3NWY,NCBI_GP:CCP45685.1;Name=CCP45685.1;Note=Rv2883c%2C (MT2951%2C MTCY274.14c)%2C len: 261 aa. Probable pyrH%2C uridylate kinase%2C equivalent to O33045|PYRH_MYCLE|ML1591|MLCB250.75 uridylate kinase from Mycobacterium leprae (279 aa)%2C FASTA scores: opt: 1437%2CE(): 3.8e-81%2C (85.05%25 identity in 274 aa overlap). Also highly similar to others e.g. O69913|PYRH from Streptomyces coelicolor (253 aa)%2C FASTA scores: opt: 1086%2C E(): 1.4e-59%2C(68.9%25 identity in 251 aa overlap)%3B P74457|PYRH_SYNY3|SLL0144 from Synechocystis sp. strain PCC 6803 (260 aa)%2C FASTA scores: opt: 851%2C E(): 4.1e-45%2C(55.85%25 identity in 231 aa overlap)%3B P29464|PYRH_ECOLI|SMBA|B0171|Z0182|ECS0173 from strains K12 and O157:H7 (240 aa)%2C FASTA scores: opt: 666%2C E(): 1.1e-35%2C(45.7%25 identity in 232 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pyrH;locus_tag=Rv2883c;product=Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase);protein_id=CCP45685.1;transl_table=11
AL123456.3	EMBL	gene	3193393	3194151	.	+	.	ID=gene-Rv2884;Name=Rv2884;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2884
AL123456.3	EMBL	CDS	3193393	3194151	.	+	0	ID=cds-CCP45686.1;Parent=gene-Rv2884;Dbxref=EnsemblGenomes-Gn:Rv2884,EnsemblGenomes-Tr:CCP45686,GOA:I6X5M3,InterPro:IPR001867,InterPro:IPR011991,InterPro:IPR016032,UniProtKB/TrEMBL:I6X5M3,NCBI_GP:CCP45686.1;Name=CCP45686.1;Note=Rv2884%2C (MTCY274.15)%2C len: 252 aa. Probable transcriptional regulatory protein%2C highly similar to others e.g. Q05943|GLNR_STRCO|SCD84.26c transcriptional regulatory protein from Streptomyces coelicolor (267 aa)%2CFASTA scores: opt: 609%2C E(): 2.7e-34%2C (46.4%25 identity in 224 aa overlap)%3B Q55733|SLL0396 regulatory components of sensory transduction system from Synechocystis sp. strain PCC 6803 (224 aa)%2C FASTA scores: opt: 330%2C E(): 3e-15%2C(31.8%25 identity in 217 aa overlap)%3B Q9A4S3|CC2757 DNA-binding response regulator from Caulobacter crescentus (223 aa)%2C FASTA scores: opt: 311%2C E(): 6e-14%2C (30.3%25 identity in 221 aa overlap)%3B etc. Also highly similar to O53830|Rv0818|MTV043.10 putative regulatory protein from Mycobacterium tuberculosis (255 aa)%2C FASTA scores: opt: 665%2C E(): 3.8e-38%2C (47.6%25 identity in 227 aa overlap). The N-terminal region is similar to that of other regulatory components of sensory transduction systems.;gbkey=CDS;locus_tag=Rv2884;product=Probable transcriptional regulatory protein;protein_id=CCP45686.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3194166	3196432	.	-	.	ID=id-AL123456.3:3194166..3196432;Note=IS1539%2C len: 2267 nt. Insertion sequence IS1539.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1539
AL123456.3	EMBL	gene	3194166	3195548	.	-	.	ID=gene-Rv2885c;Name=Rv2885c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2885c
AL123456.3	EMBL	CDS	3194166	3195548	.	-	0	ID=cds-CCP45687.1;Parent=gene-Rv2885c;Dbxref=EnsemblGenomes-Gn:Rv2885c,EnsemblGenomes-Tr:CCP45687,GOA:P9WL37,InterPro:IPR001959,InterPro:IPR010095,InterPro:IPR021027,NCBI_GP:CCP45687.1;Name=CCP45687.1;Note=Rv2885c%2C (MTCY274.16c)%2C len: 460 aa. Probable transposase for IS1539. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2885c;product=Probable transposase;protein_id=CCP45687.1;transl_table=11
AL123456.3	EMBL	gene	3195545	3196432	.	-	.	ID=gene-Rv2886c;Name=Rv2886c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2886c
AL123456.3	EMBL	CDS	3195545	3196432	.	-	0	ID=cds-CCP45688.1;Parent=gene-Rv2886c;Dbxref=EnsemblGenomes-Gn:Rv2886c,EnsemblGenomes-Tr:CCP45688,GOA:P9WL35,InterPro:IPR006119,NCBI_GP:CCP45688.1;Name=CCP45688.1;Note=Rv2886c%2C (MTCY274.17c)%2C len: 295 aa. Probable resolvase for IS1539. Contains PS00213 Lipocalin signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00213;locus_tag=Rv2886c;product=Probable resolvase;protein_id=CCP45688.1;transl_table=11
AL123456.3	EMBL	gene	3196431	3196850	.	+	.	ID=gene-Rv2887;Name=Rv2887;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2887
AL123456.3	EMBL	CDS	3196431	3196850	.	+	0	ID=cds-CCP45689.1;Parent=gene-Rv2887;Dbxref=EnsemblGenomes-Gn:Rv2887,EnsemblGenomes-Tr:CCP45689,GOA:P9WME9,InterPro:IPR000835,InterPro:IPR011991,InterPro:IPR023187,NCBI_GP:CCP45689.1;Name=CCP45689.1;Note=Rv2887%2C (MTCY274.18)%2C len: 139 aa. Probable transcriptional regulatory protein%2C highly similar to Q9EX59|SC1A4.04 putative MarR-family transcriptional regulator from Streptomyces coelicolor (151 aa)%2C FASTA scores: opt: 354%2C E(): 6.6e-16%2C (42.95%25 identity in 135 aa overlap)%3B and similar to others e.g. AAF97817|SLYA transcriptional regulator SLYA from Escherichia coli strain EPEC 2348/69 (146 aa)%2C FASTA scores: opt: 181%2C E(): 0.0001%2C(27.25%25 identity in 132 aa overlap)%3B P55740|SLYA_ECOLI|AAG56631|B1642|Z2657|ECS2351 transcriptional regulator SLYA from Escherichia coli strains K12 and O157:H7 (146 aa)%2C FASTA scores: opt: 177%2CE(): 0.00018%2C (27.25%25 identity in 132 aa overlap) %3B etc. Contains probable helix-turn-helix motif at aa 50-71 (Score 1182%2C +3.21 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2887;product=Probable transcriptional regulatory protein;protein_id=CCP45689.1;transl_table=11
AL123456.3	EMBL	gene	3196864	3198285	.	-	.	ID=gene-Rv2888c;Name=amiC;gbkey=Gene;gene=amiC;gene_biotype=protein_coding;locus_tag=Rv2888c
AL123456.3	EMBL	CDS	3196864	3198285	.	-	0	ID=cds-CCP45690.1;Parent=gene-Rv2888c;Dbxref=EnsemblGenomes-Gn:Rv2888c,EnsemblGenomes-Tr:CCP45690,GOA:P9WQ95,InterPro:IPR000120,InterPro:IPR020556,InterPro:IPR023631,NCBI_GP:CCP45690.1;Name=CCP45690.1;Note=Rv2888c%2C (MTCY274.19c)%2C len: 473 aa. Probable amiC%2Camidase%2C equivalent to O33040|AMI3_MYCLE|AMIC|ML1596|MLCB250.65 putative amidase AMIC from Mycobacterium leprae (468 aa)%2C FASTA scores: opt: 2361%2C E(): 4.2e-139%2C (76.7%25 identity in 468 aa overlap). Also similar to others e.g. Q9A8N0|CC1323 putative 6-aminohexanoate-cyclic-dimer hydrolase from Caulobacter crescentus (521 aa)%2C FASTA scores: opt: 925%2C E(): 7.4e-50%2C(36.55%25 identity in 465 aa overlap)%3B O28325|YJ54_ARCFU|AF1954 putative amidase from Archaeoglobus fulgidus (453 aa)%2C FASTA scores: opt: 659%2CE(): 2.2e-33%2C (31.1%25 identity in 460 aa overlap)%3B Q55424|AMID_SYNY3|SLL0828 putative amidase from Synechocystis sp. strain PCC 6803 (506 aa)%2C FASTA scores: opt: 643%2C E(): 2.4e-32%2C (30.7%25 identity in 466 aa overlap)%3B etc. Also similar to O05835|AMI1_MYCTU|AMIA2|Rv2363|MT2432|MTCY27.17c putative amidase AMIA2 (484 aa)%2C FASTA scores: opt: 656%2C E(): 3.6e-33%2C (35.9%25 identity in 465 aa overlap)%3B and Q11056|AMI2_MYCTU|AMIB2|Rv1263|MT1301|MTCY50.19c putative amidase from Mycobacterium tuberculosis (462 aa)%2C FASTA scores: opt: 650%2C E(): 8.2e-33%2C (33.45%25 identity in 472 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-poop). Belongs to the amidase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=amiC;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2888c;product=Probable amidase AmiC (aminohydrolase);protein_id=CCP45690.1;transl_table=11
AL123456.3	EMBL	gene	3198292	3199107	.	-	.	ID=gene-Rv2889c;Name=tsf;gbkey=Gene;gene=tsf;gene_biotype=protein_coding;locus_tag=Rv2889c
AL123456.3	EMBL	CDS	3198292	3199107	.	-	0	ID=cds-CCP45691.1;Parent=gene-Rv2889c;Dbxref=EnsemblGenomes-Gn:Rv2889c,EnsemblGenomes-Tr:CCP45691,GOA:P9WNM1,InterPro:IPR000449,InterPro:IPR001816,InterPro:IPR009060,InterPro:IPR014039,InterPro:IPR018101,NCBI_GP:CCP45691.1;Name=CCP45691.1;Note=Rv2889c%2C (MTCY274.20c)%2C len: 271 aa. Probable tsf%2Celongation factor%2C equivalent to O33039|EFTS_MYCLE|TSF|ML1597|MLCB250.64 elongation factor from Mycobacterium leprae (276 aa)%2C FASTA scores: opt: 1430%2C E(): 1.9e-80%2C (83.7%25 identity in 276 aa overlap). Also highly similar to others e.g. Q9X5Z9|EFTS_STRRA|TSF from Streptomyces ramocissimus (278 aa)%2C FASTA scores: opt: 928%2C E(): 1.1e-49%2C (57.05%25 identity in 277 aa overlap)%3B O31213|EFTS_STRCO|TSF|SC2E1.42 from Streptomyces coelicolor (278 aa)%2C FASTA scores: opt: 927%2C E(): 1.3e-49%2C (56.3%25 identity in 277 aa overlap)%3B P80700|EFTS_BACSU|TSF from Bacillus subtilis (292 aa)%2C FASTA scores: opt: 650%2C E(): 1.3e-32%2C (43.85%25 identity in 276 aa overlap)%3B etc. Contains PS01127 Elongation factor Ts signature 2. Belongs to the EF-ts family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tsf;inference=protein motif:PROSITE:PS01127;locus_tag=Rv2889c;product=Probable elongation factor Tsf (EF-ts);protein_id=CCP45691.1;transl_table=11
AL123456.3	EMBL	gene	3199119	3199982	.	-	.	ID=gene-Rv2890c;Name=rpsB;gbkey=Gene;gene=rpsB;gene_biotype=protein_coding;locus_tag=Rv2890c
AL123456.3	EMBL	CDS	3199119	3199982	.	-	0	ID=cds-CCP45692.1;Parent=gene-Rv2890c;Dbxref=EnsemblGenomes-Gn:Rv2890c,EnsemblGenomes-Tr:CCP45692,GOA:P9WH39,InterPro:IPR001865,InterPro:IPR005706,InterPro:IPR018130,InterPro:IPR023591,NCBI_GP:CCP45692.1;Name=CCP45692.1;Note=Rv2890c%2C (MTCY274.21c)%2C len: 287 aa. rpsB%2C 30s ribosomal protein s2%2C equivalent to O33038|RS2_MYCLE|RPSB|ML1598|MLCB250.63 30S ribosomal protein S2 from Mycobacterium leprae (277 aa)%2C FASTA scores: opt: 1593%2C E(): 2.3e-93%2C (91.5%25 identity in 270 aa overlap). Also highly similar to others e.g. O31212|RS2_STRCO|RPSB|SC2E1.41 from Streptomyces coelicolor (310 aa)%2C FASTA scores: opt: 1302%2C E(): 6.1e-75%2C (70.6%25 identity in 289 aa overlap)%3B Q9KA63|RPSB|BH2427 from Bacillus halodurans (244 aa)%2C FASTA scores: opt: 991%2C E(): 2.3e-55%2C (59.6%25 identity in 255 aa overlap)%3B P21464|RS2_BACSU|RPSB from Bacillus subtilis (245 aa)%2CFASTA scores: opt: 959%2C E(): 2.4e-53%2C (58.55%25 identity in 246 aa overlap)%3B etc. Contains PS00962 Ribosomal protein S2 signature 1. Belongs to the S2P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsB;inference=protein motif:PROSITE:PS00962;locus_tag=Rv2890c;product=30S ribosomal protein S2 RpsB;protein_id=CCP45692.1;transl_table=11
AL123456.3	EMBL	gene	3200266	3201015	.	+	.	ID=gene-Rv2891;Name=Rv2891;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2891
AL123456.3	EMBL	CDS	3200266	3201015	.	+	0	ID=cds-CCP45693.1;Parent=gene-Rv2891;Dbxref=EnsemblGenomes-Gn:Rv2891,EnsemblGenomes-Tr:CCP45693,InterPro:IPR011055,InterPro:IPR016047,NCBI_GP:CCP45693.1;Name=CCP45693.1;Note=Rv2891%2C (MTCY274.22)%2C len: 249 aa (C-terminus overlaps neigbouring ORF). Conserved hypothetical protein%2Csimilar in N-terminus to O69910|SC2E1.40c hypothetical 22.8 KDA protein from Streptomyces coelicolor (226 aa)%2C FASTA scores: opt: 315%2C E(): 3.4e-11%2C (40.7%25 identity in 145 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv2891;product=Conserved hypothetical protein;protein_id=CCP45693.1;transl_table=11
AL123456.3	EMBL	gene	3200794	3202020	.	-	.	ID=gene-Rv2892c;Name=PPE45;gbkey=Gene;gene=PPE45;gene_biotype=protein_coding;locus_tag=Rv2892c
AL123456.3	EMBL	CDS	3200794	3202020	.	-	0	ID=cds-CCP45694.1;Parent=gene-Rv2892c;Dbxref=EnsemblGenomes-Gn:Rv2892c,EnsemblGenomes-Tr:CCP45694,GOA:P9WHZ1,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP45694.1;Name=CCP45694.1;Note=Rv2892c%2C (MTCY274.23c)%2C len: 408 aa. PPE45%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. O06386|Rv3621c|MTCY15C10.31|MTCY07H7B.01 from M. tuberculosis (413 aa)%2C FASTA scores: opt: 957%2C E(): 6.2e-46%2C (44.7%25 identity in 423 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE45;locus_tag=Rv2892c;product=PPE family protein PPE45;protein_id=CCP45694.1;transl_table=11
AL123456.3	EMBL	gene	3202420	3203397	.	+	.	ID=gene-Rv2893;Name=Rv2893;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2893
AL123456.3	EMBL	CDS	3202420	3203397	.	+	0	ID=cds-CCP45695.1;Parent=gene-Rv2893;Dbxref=EnsemblGenomes-Gn:Rv2893,EnsemblGenomes-Tr:CCP45695,GOA:I6YEN3,InterPro:IPR011251,InterPro:IPR019923,UniProtKB/TrEMBL:I6YEN3,NCBI_GP:CCP45695.1;Name=CCP45695.1;Note=Rv2893%2C (MTCY274.24)%2C len: 325 aa. Possible oxidoreductase%2C showing similarity with various proteins and/or oxidoreductases e.g. Q9AE05|RIF11 eleventh protein in the rif biosynthetic gene cluster from Amycolatopsis mediterranei (Nocardia mediterranei) (294 aa)%2C FASTA scores: opt: 270%2C E(): 4.8e-10%2C (34.5%25 identity in 313 aa overlap)%3B O52567 reductase from Amycolatopsis mediterranei (Nocardia mediterranei) (153 aa)%2C FASTA scores: opt: 251%2CE(): 5e-09%2C (42.4%25 identity in 125 aa overlap)%3B Q58929|mer|MJ1534 F420-dependent methylenetetrahydromethanopterin reductase from Methanococcus jannaschii (331 aa)%2C FASTA scores: opt: 249%2CE(): 1.2e-08%2C (29.7%25 identity in 283 aa overlap)%3B etc. Also some similarity with others proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. P71844|Rv0791c|MTCY369.35c putative oxidoreductase (347 aa)%2C FASTA scores: opt: 264%2C E(): 1.3e-09%2C (29.05%25 identity in 272 aa overlap)%3B and P96809|Rv0132|MTCI5.06c putative oxidoreductase (360 aa)%2C FASTA scores: opt: 260%2C E(): 2.4e-09%2C (33.05%25 identity in 239 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2893;product=Possible oxidoreductase;protein_id=CCP45695.1;transl_table=11
AL123456.3	EMBL	gene	3203394	3204290	.	-	.	ID=gene-Rv2894c;Name=xerC;gbkey=Gene;gene=xerC;gene_biotype=protein_coding;locus_tag=Rv2894c
AL123456.3	EMBL	CDS	3203394	3204290	.	-	0	ID=cds-CCP45696.1;Parent=gene-Rv2894c;Dbxref=EnsemblGenomes-Gn:Rv2894c,EnsemblGenomes-Tr:CCP45696,GOA:P9WF35,InterPro:IPR002104,InterPro:IPR004107,InterPro:IPR011010,InterPro:IPR013762,InterPro:IPR023009,InterPro:IPR023109,NCBI_GP:CCP45696.1;Name=CCP45696.1;Note=Rv2894c%2C (MTCY274.25c)%2C len: 298 aa. Probable xerC%2Cintegrase/recombinase%2C equivalent to Q9CBU0|XERC|ML1600|MLCB250.62 integrase/recombinase from Mycobacterium leprae (297 aa)%2C FASTA scores: opt: 1624%2CE(): 2e-97%2C (85.15%25 identity in 296 aa overlap). Also highly similar to others integrases/recombinases (generally xerC and xerD) e.g. Q9HTS4|SSS|PA5280 site-specific recombinase from Pseudomonas aeruginosa (303 aa)%2C FASTA scores: opt: 660%2C E(): 3.2e-35%2C (41.8%25 identity in 299 aa overlap)%3B Q9HXQ6|XERD|PA3738 integrase/recombinase from Pseudomonas aeruginosa (298 aa)%2C FASTA scores: opt: 656%2CE(): 5.7e-35%2C (40.05%25 identity in 297 aa overlap)%3B Q9KCP0|BH1529 integrase/recombinase from Bacillus halodurans (299 aa)%2C FASTA scores: opt: 645%2C E(): 2.9e-34%2C(37.35%25 identity in 300 aa overlap)%3B etc. Also similar to O33200|Rv1701|MTCI125.23 integrase/recombinase from Mycobacterium tuberculosis (311 aa)%2C FASTA scores: opt: 646%2C E(): 2.6e-34%2C (43.1%25 identity in 304 aa overlap). Belongs to the 'phage' integrase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=xerC;locus_tag=Rv2894c;product=Probable integrase/recombinase XerC;protein_id=CCP45696.1;transl_table=11
AL123456.3	EMBL	gene	3204381	3205232	.	-	.	ID=gene-Rv2895c;Name=viuB;gbkey=Gene;gene=viuB;gene_biotype=protein_coding;locus_tag=Rv2895c
AL123456.3	EMBL	CDS	3204381	3205232	.	-	0	ID=cds-CCP45697.1;Parent=gene-Rv2895c;Dbxref=EnsemblGenomes-Gn:Rv2895c,EnsemblGenomes-Tr:CCP45697,GOA:P9WL31,InterPro:IPR007037,InterPro:IPR013113,InterPro:IPR017927,InterPro:IPR017938,NCBI_GP:CCP45697.1;Name=CCP45697.1;Note=Rv2895c%2C (MT2963%2C MTCY274.26c)%2C len: 283 aa. Possible viuB%2C mycobactin utilization protein%2C highly similar to Q9RJ78|SCI41.06 hypothetical 31.5 KDA protein from Streptomyces coelicolor (280 aa)%2C FASTA scores: opt: 639%2C E(): 5.1e-32%2C (46.3%25 identity in 285 aa overlap)%3B and similar to other proteins e.g. Q9F641|MXCB protein of the biosynthetic gene cluster of the myxochelin-type iron chelator from Stigmatella aurantiaca (270 aa)%2C FASTA scores: opt: 417%2C E(): 2.2e-18%2C (34.2%25 identity in 263 aa overlap)%3B Q56646|VIUB_VIBCH|VC2210 vibriobactin utilization protein from Vibrio cholerae (271 aa)%2C FASTA scores: opt: 395%2C E(): 5.1e-17%2C (31.0%25 identity in 274 aa overlap)%3B Q56743|VIUB_VIBVU vulnibactin utilization protein V from Vibrio vulnificus (271 aa)%2C FASTA scores: opt: 390%2C E(): 1e-16%2C (33.95%25 identity in 274 aa overlap)%3B etc. Equivalent to AAK47289 from Mycobacterium tuberculosis strain CDC1551 (321 aa) but shorter 38 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=viuB;locus_tag=Rv2895c;product=Possible mycobactin utilization protein ViuB;protein_id=CCP45697.1;transl_table=11
AL123456.3	EMBL	gene	3205265	3206434	.	-	.	ID=gene-Rv2896c;Name=Rv2896c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2896c
AL123456.3	EMBL	CDS	3205265	3206434	.	-	0	ID=cds-CCP45698.1;Parent=gene-Rv2896c;Dbxref=EnsemblGenomes-Gn:Rv2896c,EnsemblGenomes-Tr:CCP45698,GOA:P9WL29,InterPro:IPR003488,NCBI_GP:CCP45698.1;Name=CCP45698.1;Note=Rv2896c%2C (MTCY274.27c)%2C len: 389 aa. Conserved hypothetical protein%2C similar to others proteins e.g. Q9ZJ08|FIR2 from Rhodococcus fascians (293 aa)%2C FASTA scores: opt: 663%2C E(): 3.3e-32%2C (43.7%25 identity in 286 aa overlap)%3B O69892|SC2E1.21 hypothetical 37.9 KDA protein from Streptomyces coelicolor (382 aa)%2C FASTA scores: opt: 600%2C E(): 2.2e-28%2C (46.45%25 identity in 267 aa overlap)%3B Q9JWZ4|DPRA|NMA0158 DPRA homolog from Neisseria meningitidis (serogroup A) (395 aa)%2C FASTA scores: opt: 495%2C E(): 4.1e-22%2C (34.6%25 identity in 347 aa overlap)%3B etc. Nucleotide position 3205978 in the genome sequence has been corrected%2C A:C resulting in S153A.;gbkey=CDS;locus_tag=Rv2896c;product=Conserved hypothetical protein;protein_id=CCP45698.1;transl_table=11
AL123456.3	EMBL	gene	3206431	3207942	.	-	.	ID=gene-Rv2897c;Name=Rv2897c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2897c
AL123456.3	EMBL	CDS	3206431	3207942	.	-	0	ID=cds-CCP45699.1;Parent=gene-Rv2897c;Dbxref=EnsemblGenomes-Gn:Rv2897c,EnsemblGenomes-Tr:CCP45699,GOA:P9WPR1,InterPro:IPR000523,InterPro:IPR003593,InterPro:IPR004482,InterPro:IPR014721,InterPro:IPR020568,InterPro:IPR025158,InterPro:IPR027417,NCBI_GP:CCP45699.1;Name=CCP45699.1;Note=Rv2897c%2C (MTCY274.28c)%2C len: 503 aa. Conserved hypothetical protein%2C possibly Mg-chelatase%2C highly similar to hypothetical proteins and chelatases e.g. Q9RTV0|DR1656 mg(2+) chelatase family protein from Deinococcus radiodurans (519 aa)%2C FASTA scores: opt: 1333%2C E(): 3.6e-68%2C (46.55%25 identity in 505 aa overlap)%3BQ55372|SLR0904 hypothetical 55.1 KDA protein from Synechocystis sp. strain PCC 6803 (509 aa)%2C FASTA scores: opt: 1271%2C E(): 1.2e-64%2C(42.65%25 identity in 504 aa overlap)%3B Q9HTR4|PA5290 hypothetical protein from Pseudomonas aeruginosa (497 aa)%2CFASTA scores: opt: 1248%2C E(): 2.3e-63%2C (45.9%25 identity in 503 aa overlap)%3B Q9K0Z6|comm|NMB0405 competence protein (mg-chelatase) from Neisseria meningitidis (serogroup B)%2CFASTA scores: opt: 1229%2C E(): 2.8e-62%2C (43.2%25 identity in 509 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2897c;product=Conserved hypothetical protein;protein_id=CCP45699.1;transl_table=11
AL123456.3	EMBL	gene	3207942	3208328	.	-	.	ID=gene-Rv2898c;Name=Rv2898c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2898c
AL123456.3	EMBL	CDS	3207942	3208328	.	-	0	ID=cds-CCP45700.1;Parent=gene-Rv2898c;Dbxref=EnsemblGenomes-Gn:Rv2898c,EnsemblGenomes-Tr:CCP45700,GOA:P9WFM9,InterPro:IPR003509,InterPro:IPR011335,InterPro:IPR011856,NCBI_GP:CCP45700.1;Name=CCP45700.1;Note=Rv2898c%2C (MTCY274.29c)%2C len: 128 aa. Conserved hypothetical protein%2C highly similar to O33024|YS98_MYCLE|ML1607|MLCB250.49 hypothetical 11.0 KDA protein from Mycobacterium leprae (96 aa)%2C FASTA scores: opt: 318%2C E(): 2.3e-16%2C (58.35%25 identity in 96 aa overlap). Also similar to other hypothetical proteins e.g. O69890|YE19_STRCO|SC2E1.19 from Streptomyces coelicolor (130 aa)%2C FASTA scores: opt: 253%2C E(): 1.7e-11%2C (39.65%25 identity in 121 aa overlap)%3B Q9HVZ1|PA4424 from Pseudomonas aeruginosa (125 aa)%2C FASTA scores: opt: 234%2C E(): 4.2e-10%2C(40.85%25 identity in 115 aa overlap)%3B O86871 from Streptomyces lividans (85 aa)%2C FASTA scores: opt: 224%2C E(): 1.8e-09%2C (46.45%25 identity in 84 aa overlap)%3B etc. Equivalent to AAK47292 from Mycobacterium tuberculosis strain CDC1551 (141 aa) but shorter 13 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv2898c;product=Conserved hypothetical protein;protein_id=CCP45700.1;transl_table=11
AL123456.3	EMBL	gene	3208576	3209406	.	-	.	ID=gene-Rv2899c;Name=fdhD;gbkey=Gene;gene=fdhD;gene_biotype=protein_coding;locus_tag=Rv2899c
AL123456.3	EMBL	CDS	3208576	3209406	.	-	0	ID=cds-CCP45701.1;Parent=gene-Rv2899c;Dbxref=EnsemblGenomes-Gn:Rv2899c,EnsemblGenomes-Tr:CCP45701,GOA:P9WNF1,InterPro:IPR003786,InterPro:IPR016193,NCBI_GP:CCP45701.1;Name=CCP45701.1;Note=Rv2899c%2C (MTCY274.30c)%2C len: 276 aa. Possible fdhD protein homolog%2C highly similar to other bacterial fdhd protein homologs or formate dehydrogenase accessory proteins e.g. Q9ZBW0|FDHD_STRCO|SC4B5.08c from Streptomyces coelicolor (282 aa)%2C FASTA scores: opt: 1032%2C E(): 3.6e-59%2C(59.0%25 identity in 278 aa overlap)%3B BAB59387|TVG0258796 from Thermoplasma volcanium (279 aa)%2C FASTA scores: opt: 536%2C E(): 3.4e-27%2C (38.65%25 identity in 282 aa overlap)%3B Q9HL17|FDHD_THEAC|TA0423 from Thermoplasma acidophilum (282 aa)%2C FASTA scores: opt: 529%2C E(): 9.6e-27%2C (38.8%25 identity in 281 aa overlap)%3B P32177|FDHD_ECOLI FDHD protein from Escherichia coli strain K12 (277 aa)%2C FASTA scores: opt: 297%2C E(): 8.6e-12%2C (33.35%25 identity in 261 aa overlap)%3B etc. Contain a Pfam match to entry PF02634 FdhD/NarQ family. Belongs to the FdhD family.;gbkey=CDS;gene=fdhD;locus_tag=Rv2899c;product=Possible FdhD protein homolog;protein_id=CCP45701.1;transl_table=11
AL123456.3	EMBL	gene	3209406	3211745	.	-	.	ID=gene-Rv2900c;Name=fdhF;gbkey=Gene;gene=fdhF;gene_biotype=protein_coding;locus_tag=Rv2900c
AL123456.3	EMBL	CDS	3209406	3211745	.	-	0	ID=cds-CCP45702.1;Parent=gene-Rv2900c;Dbxref=EnsemblGenomes-Gn:Rv2900c,EnsemblGenomes-Tr:CCP45702,GOA:P9WJP9,InterPro:IPR006656,InterPro:IPR006657,InterPro:IPR009010,InterPro:IPR010046,NCBI_GP:CCP45702.1;Name=CCP45702.1;Note=Rv2900c%2C (MTCY274.31c)%2C len: 779 aa. Possible fdhF%2Cformate dehydrogenase%2C highly similar to others formate dehydrogenases and prokaryotic molybdopterin-containing oxidoreductases e.g. Q9S2J9|SC7H2.18 putative formate dehydrogenase from Streptomyces coelicolor (759 aa)%2C FASTA scores: opt: 3038%2C E(): 2.7e-180%2C (59.7%25 identity in 767 aa overlap)%3B Q9HU08|PA5181 probable oxidoreductase from Pseudomonas aeruginosa (773 aa)%2C FASTA scores: opt: 2560%2CE(): 1.1e-150%2C (53.2%25 identity in 761 aa overlap)%3B P78160 formate dehydrogenase a chain (fragment) from Escherichia coli strain K12 (740 aa)%2C FASTA scores: opt: 2002%2C E(): 3.7e-116%2C (43.1%25 identity in 733 aa overlap)%3B P07658|FDHF_ECOLI|P78137|B4079 formate dehydrogenase from Escherichia coli strain K12 (715 aa)%2C FASTA scores: opt: 305%2C E(): 5.6e-13%2C (25.5%25 identity in 748 aa overlap)%3B etc. Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fdhF;locus_tag=Rv2900c;product=Possible formate dehydrogenase H FdhF (formate-hydrogen-lyase-linked%2C selenocysteine-containing polypeptide) (formate dehydrogenase-H alpha subunit) (FDH-H);protein_id=CCP45702.1;transl_table=11
AL123456.3	EMBL	gene	3211803	3212108	.	-	.	ID=gene-Rv2901c;Name=Rv2901c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2901c
AL123456.3	EMBL	CDS	3211803	3212108	.	-	0	ID=cds-CCP45703.1;Parent=gene-Rv2901c;Dbxref=EnsemblGenomes-Gn:Rv2901c,EnsemblGenomes-Tr:CCP45703,GOA:P9WL27,InterPro:IPR019592,NCBI_GP:CCP45703.1;Name=CCP45703.1;Note=Rv2901c%2C (MTCY274.32c)%2C len: 101 aa. Conserved protein%2C very equivalent to O33023|ML1610|MLCB250.41 hypothetical 12.3 KDA protein from Mycobacterium leprae (101 aa)%2C FASTA scores: opt: 658%2C E(): 2.6e-43%2C (99.0%25 identity in 101 aa overlap). Also highly similar to O69889|SC2E1.18 hypothetical protein from Streptomyces coelicolor and Streptomyces lividans (102 aa)%2C FASTA scores: opt: 515%2C E(): 2.2e-32%2C (75.0%25 identity in 100 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2901c;product=Conserved protein;protein_id=CCP45703.1;transl_table=11
AL123456.3	EMBL	gene	3212162	3212956	.	-	.	ID=gene-Rv2902c;Name=rnhB;gbkey=Gene;gene=rnhB;gene_biotype=protein_coding;locus_tag=Rv2902c
AL123456.3	EMBL	CDS	3212162	3212956	.	-	0	ID=cds-CCP45704.1;Parent=gene-Rv2902c;Dbxref=EnsemblGenomes-Gn:Rv2902c,EnsemblGenomes-Tr:CCP45704,GOA:P9WH01,InterPro:IPR001352,InterPro:IPR012337,InterPro:IPR022898,InterPro:IPR024567,NCBI_GP:CCP45704.1;Name=CCP45704.1;Note=Rv2902c%2C (MT2970%2C MTCY274.33c)%2C len: 264 aa. Probable rnhB%2C ribonuclease HII%2C equivalent to O33022|RNH2_MYCLE|RNHB|ML1611|MLCB250.40 ribonuclease HII from Mycobacterium leprae (240 aa)%2C FASTA scores: opt: 1242%2C E(): 6.9e-72%2C (76.75%25 identity in 245 aa overlap). Also similar (but longer ~~20 aa) to others e.g. Q9HXY9|RNHB|PA3642 ribonuclease HII from Pseudomonas aeruginosa (201 aa)%2C FASTA scores: opt: 572%2C E(): 3.1e-29%2C(52.7%25 identity in 184 aa overlap)%3B Q9PEI7|RNH2_XYLFA|RNHB|XF1041 ribonuclease HII from Xylella fastidiosa (234 aa)%2C FASTA scores: opt: 556%2C E(): 3.6e-28%2C(50.25%25 identity in 185 aa overlap)%3B P10442|RNH2_ECOLI|RNHB|B0183 ribonuclease HII from Escherichia coli strain K-12 (213 aa)%2C FASTA scores: opt: 519%2C E(): 7.4e-26%2C (48.65%25 identity in 183 aa overlap)%3B etc. Belongs to the RNASE HII family. Cofactor: manganese (by similarity).;gbkey=CDS;gene=rnhB;locus_tag=Rv2902c;product=Probable ribonuclease HII protein RnhB (RNase HII);protein_id=CCP45704.1;transl_table=11
AL123456.3	EMBL	gene	3212970	3213854	.	-	.	ID=gene-Rv2903c;Name=lepB;gbkey=Gene;gene=lepB;gene_biotype=protein_coding;locus_tag=Rv2903c
AL123456.3	EMBL	CDS	3212970	3213854	.	-	0	ID=cds-CCP45705.1;Parent=gene-Rv2903c;Dbxref=EnsemblGenomes-Gn:Rv2903c,EnsemblGenomes-Tr:CCP45705,GOA:P9WKA1,InterPro:IPR000223,InterPro:IPR015927,InterPro:IPR019533,InterPro:IPR019756,InterPro:IPR019758,InterPro:IPR019759,InterPro:IPR028360,NCBI_GP:CCP45705.1;Name=CCP45705.1;Note=Rv2903c%2C (MTCY274.34c)%2C len: 294 aa. Probable lepB%2Csignal peptidase I (type II membrane protein) (see Braunstein %26 Belisle 2000)%2C equivalent to O33021|LEP_MYCLE|ML1612|MLCB250.39 probable signal peptidase I from Mycobacterium leprae (289 aa)%2C FASTA scores: opt: 1335%2C E(): 1.8e-77%2C (69.75%25 identity in 301 aa overlap). Also similar to many e.g. O86869|SIPX signal peptidase I from Streptomyces lividans (320 aa)%2C FASTA scores: opt: 474%2C E(): 1e-22%2C (43.55%25 identity in 248 aa overlap)%3B O69884|SIP1|SIPW putative signal peptidase I from Streptomyces coelicolor and Streptomyces lividans (259 aa)%2CFASTA scores: opt: 226%2C E(): 5e-07%2C (36.0%25 identity in 214 aa overlap)%3B P42668|LEP_BACLI|sip signal peptidase I from Bacillus licheniformis (186 aa)%2C FASTA scores: opt: 218%2CE(): 1.3e-06%2C (34.5%25 identity in 194 aa overlap)%3B etc. Contains PS00501 Signal peptidases I serine active site%2Cand PS00761 Signal peptidases I signature 3. Belongs to peptidase family S26%3B also known as type I leader peptidase family. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lepB;inference=protein motif:PROSITE:PS00761;locus_tag=Rv2903c;product=Probable signal peptidase I LepB (SPASE I) (leader peptidase I).;protein_id=CCP45705.1;transl_table=11
AL123456.3	EMBL	gene	3213912	3214253	.	-	.	ID=gene-Rv2904c;Name=rplS;gbkey=Gene;gene=rplS;gene_biotype=protein_coding;locus_tag=Rv2904c
AL123456.3	EMBL	CDS	3213912	3214253	.	-	0	ID=cds-CCP45706.1;Parent=gene-Rv2904c;Dbxref=EnsemblGenomes-Gn:Rv2904c,EnsemblGenomes-Tr:CCP45706,GOA:P9WHC9,InterPro:IPR001857,InterPro:IPR008991,InterPro:IPR018257,NCBI_GP:CCP45706.1;Name=CCP45706.1;Note=Rv2904c%2C (MTCY274.35c)%2C len: 113 aa. rplS%2C 50S ribosomal protein L19%2C equivalent to O33020|RL19_MYCLE 50S ribosomal protein L19 from Mycobacterium leprae (113 aa)%2CFASTA scores: opt: 702%2C E(): 1.4e-45%2C (93.8%25 identity in 113 aa overlap). Also highly similar to others e.g. O69883|RL19_STRCO from Streptomyces coelicolor (116 aa)%2CFASTA scores: opt: 571%2C E(): 9.5e-36%2C (77.25%25 identity in 110 aa overlap)%3B O31742|RL19_BACSU from Bacillus subtilis (115 aa)%2C FASTA scores: opt: 523%2C E(): 3.8e-32%2C (72.9%25 identity in 107 aa overlap)%3B RL19_BACST|P30529 from Bacillus stearothermophilus (116 aa)%2C FASTA scores: opt: 518%2C E(): 9.1e-32%2C (71.7%25 identity in 106 aa overlap)%3B etc. Belongs to the L19P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplS;locus_tag=Rv2904c;product=50S ribosomal protein L19 RplS;protein_id=CCP45706.1;transl_table=11
AL123456.3	EMBL	gene	3214628	3215572	.	+	.	ID=gene-Rv2905;Name=lppW;gbkey=Gene;gene=lppW;gene_biotype=protein_coding;locus_tag=Rv2905
AL123456.3	EMBL	CDS	3214628	3215572	.	+	0	ID=cds-CCP45707.1;Parent=gene-Rv2905;Dbxref=EnsemblGenomes-Gn:Rv2905,EnsemblGenomes-Tr:CCP45707,GOA:P9WK67,InterPro:IPR012338,NCBI_GP:CCP45707.1;Name=CCP45707.1;Note=Rv2905%2C (MTCY274.36)%2C len: 314 aa. Probable lppW%2Cconserved ala-rich lipoprotein%2C with slight similarity to beta-lactamases and hypothetical proteins e.g. Q9S1P7|SCJ9A.23 hypothetical 36.3 KDA protein from Streptomyces coelicolor (336 aa)%2C FASTA scores: opt: 222%2CE(): 2.8e-06%2C (25.5%25 identity in 298 aa overlap)%3B O69914|SC3C8.01 putative secreted protein from Streptomyces coelicolor (302 aa)%2C FASTA scores: opt: 201%2C E(): 5.1e-05%2C(24.9%25 identity in 257 aa overlap)%3B P14559|BLAC_STRAL beta-lactamase precursor from Streptomyces albus G (314 aa)%2C FASTA scores: opt: 113%2C E(): 3.3%2C (25.2%25 identity in 278 aa overlap)%3B etc. Has signal peptide and appropriately positioned prokaryotic lipoprotein lipid attachment site: attached to the membrane by a lipid anchor (potential).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppW;locus_tag=Rv2905;product=Probable conserved alanine rich lipoprotein LppW;protein_id=CCP45707.1;transl_table=11
AL123456.3	EMBL	gene	3215665	3216357	.	-	.	ID=gene-Rv2906c;Name=trmD;gbkey=Gene;gene=trmD;gene_biotype=protein_coding;locus_tag=Rv2906c
AL123456.3	EMBL	CDS	3215665	3216357	.	-	0	ID=cds-CCP45708.1;Parent=gene-Rv2906c;Dbxref=EnsemblGenomes-Gn:Rv2906c,EnsemblGenomes-Tr:CCP45708,GOA:P9WFY7,InterPro:IPR002649,InterPro:IPR016009,InterPro:IPR023148,InterPro:IPR029026,InterPro:IPR029028,NCBI_GP:CCP45708.1;Name=CCP45708.1;Note=Rv2906c%2C (MTCY274.37c)%2C len: 230 aa. Probable trmD%2CtRNA m1G methyltransferase%2C equivalent to O33017|TRMD_MYCLE from Mycobacterium leprae (238 aa)%2C FASTA scores: opt: 1363%2C E(): 8.1e-86%2C (87.2%25 identity in 227 aa overlap). Also highly similar to others e.g. O69882|TRMD_STRCO from Streptomyces coelicolor and S. lividans (277 aa)%2C FASTA scores: opt: 841%2C E(): 4.5e-50%2C (55.55%25 identity in 234 aa overlap)%3B Q9A0B6 from Streptococcus pyogenes (243 aa)%2CFASTA scores: opt: 698%2C E(): 2.5e-40%2C (47.6%25 identity in 227 aa overlap)%3B P07020|TRMD_ECOLI|TRMD|B2607|Z3901|ECS3470 from Escherichia coli strain O157:H7 (255 aa)%2C FASTA scores: opt: 573%2C E(): 3.8e-33%2C (42.1%25 identity in 228 aa overlap)%3B etc. Belongs to the RNA methyltransferase TRMD family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trmD;locus_tag=Rv2906c;product=Probable tRNA (guanine-N1)-methyltransferase TrmD (M1G-methyltransferase) (tRNA [GM37] methyltransferase);protein_id=CCP45708.1;transl_table=11
AL123456.3	EMBL	gene	3216361	3216891	.	-	.	ID=gene-Rv2907c;Name=rimM;gbkey=Gene;gene=rimM;gene_biotype=protein_coding;locus_tag=Rv2907c
AL123456.3	EMBL	CDS	3216361	3216891	.	-	0	ID=cds-CCP45709.1;Parent=gene-Rv2907c;Dbxref=EnsemblGenomes-Gn:Rv2907c,EnsemblGenomes-Tr:CCP45709,GOA:P9WH19,InterPro:IPR002676,InterPro:IPR009000,InterPro:IPR011033,InterPro:IPR011961,InterPro:IPR027275,NCBI_GP:CCP45709.1;Name=CCP45709.1;Note=Rv2907c%2C (MTCY274.38c)%2C len: 176 aa. Probable rimM%2C16S rRNA processing protein%2C equivalent to O33016|RIMM_MYCLE probable 16S rRNA processing protein from Mycobacterium leprae (179 aa)%2C FASTA scores: opt: 797%2C E(): 2.4e-46%2C (73.15%25 identity in 175 aa overlap). Also highly similar to others e.g. O69881|RIMM_STRCO from Streptomyces coelicolor (188 aa)%2C FASTA scores: opt: 485%2C E(): 2.3e-25%2C(48.85%25 identity in 176 aa overlap)%3B Q9KA14|RIMM_BACHD from Bacillus halodurans (173 aa)%2C FASTA scores: opt: 289%2C E(): 3.2e-12%2C (30.65%25 identity in 173 aa overlap)%3B P21504|RIMM_ECOLI|RIMM|B2608 from Escherichia coli strain K12 (182 aa)%2C FASTA scores: opt: 237%2C E(): 1e-08%2C (29.4%25 identity in 177 aa overlap). Belongs to the RimM family.;gbkey=CDS;gene=rimM;locus_tag=Rv2907c;product=Probable 16S rRNA processing protein RimM;protein_id=CCP45709.1;transl_table=11
AL123456.3	EMBL	gene	3216905	3217147	.	-	.	ID=gene-Rv2908c;Name=Rv2908c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2908c
AL123456.3	EMBL	CDS	3216905	3217147	.	-	0	ID=cds-CCP45710.1;Parent=gene-Rv2908c;Dbxref=EnsemblGenomes-Gn:Rv2908c,EnsemblGenomes-Tr:CCP45710,GOA:P9WFM7,InterPro:IPR004088,InterPro:IPR009019,InterPro:IPR020627,NCBI_GP:CCP45710.1;Name=CCP45710.1;Note=Rv2908c%2C (MTCY274.40c)%2C len: 80 aa. Conserved hypothetical protein%2C equivalent to O33015|YT08_MYCLE from Mycobacterium leprae (80 aa)%2C FASTA scores: opt: 492%2C E(): 3.1e-29%2C (93.75%25 identity in 80 aa overlap). Also highly similar to others e.g. O69880|YE09_STRCO from Streptomyces coelicolor (79 aa)%2C FASTA scores: opt: 356%2C E(): 3e-19%2C(71.6%25 identity in 74 aa overlap)%3B Q9KA12|BH2482 protein from Bacillus halodurans (76 aa)%2C FASTA scores: opt: 220%2CE(): 2.9e-09%2C (48.6%25 identity in 72 aa overlap)%3B O31738|YLQC_BACSU hypothetical 9.1 KDA protein from Bacillus subtilis (81 aa)%2C FASTA scores: opt: 172%2C E(): 1e-05%2C (39.2%25 identity in 74 aa overlap)%3B etc. Belongs to the UPF0109 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2908c;product=Conserved hypothetical protein;protein_id=CCP45710.1;transl_table=11
AL123456.3	EMBL	gene	3217155	3217643	.	-	.	ID=gene-Rv2909c;Name=rpsP;gbkey=Gene;gene=rpsP;gene_biotype=protein_coding;locus_tag=Rv2909c
AL123456.3	EMBL	CDS	3217155	3217643	.	-	0	ID=cds-CCP45711.1;Parent=gene-Rv2909c;Dbxref=EnsemblGenomes-Gn:Rv2909c,EnsemblGenomes-Tr:CCP45711,GOA:P9WH53,InterPro:IPR000307,InterPro:IPR020592,InterPro:IPR023803,NCBI_GP:CCP45711.1;Name=CCP45711.1;Note=Rv2909c%2C (MTCY274.41c)%2C len: 162 aa. rpsP%2C 30S ribosomal protein S16%2C equivalent to O33014|RS16_MYCLE 30S ribosomal protein S16 from Mycobacterium leprae (160 aa)%2CFASTA scores: opt: 828%2C E(): 1.6e-39%2C (82.5%25 identity in 160 aa overlap). Also highly similar to others e.g. O69879|RS16_STRCO 30S ribosomal protein S16 from Streptomyces coelicolor (139 aa)%2C FASTA scores: opt: 486%2CE(): 1.9e-20%2C (56.95%25 identity in 144 aa overlap)%3B P80379|RS16_THETH 30S ribosomal protein S16 from Thermus Thermophilus (88 aa)%2C FASTA scores: opt: 280%2C E(): 4.8e-09%2C(53.25%25 identity in 77 aa overlap) (C-terminus shorter)%3B P21474|RS16_BACSU|RPSP 30S ribosomal protein S16 (BS17) from Bacillus subtilis (89 aa%2C)%2C FASTA scores: opt: 258%2CE(): 8.2e-08%2C (42.85%25 identity in 91 aa overlap) (C-terminus shorter)%3B etc. Belongs to the S16P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsP;locus_tag=Rv2909c;product=30S ribosomal protein S16 RpsP;protein_id=CCP45711.1;transl_table=11
AL123456.3	EMBL	gene	3217827	3218270	.	-	.	ID=gene-Rv2910c;Name=Rv2910c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2910c
AL123456.3	EMBL	CDS	3217827	3218270	.	-	0	ID=cds-CCP45712.1;Parent=gene-Rv2910c;Dbxref=EnsemblGenomes-Gn:Rv2910c,EnsemblGenomes-Tr:CCP45712,NCBI_GP:CCP45712.1;Name=CCP45712.1;Note=Rv2910c%2C (MTCY274.42c)%2C len: 147 aa. Conserved hypothetical protein%2C showing some similarity with hypothetical proteins from other organisms e.g. Q9JN76|MMYY hypothetical 17.4 KDA protein from Streptomyces coelicolor (153 aa)%2C FASTA scores: opt: 164%2C E(): 0.00026%2C (35.05%25 identity in 129 aa overlap)%3B etc. Also some similarity with protein from Mycobacterium tuberculosis e.g. O07237|Rv0310c|MTCY63.15c (163 aa)%2C FASTA scores: opt: 165%2CE(): 0.00023%2C (26.3%25 identity in 137 aa overlap)%3B P96815|Rv0138|MTCI5.12 (167 aa)%2C FASTA scores: opt: 132%2CE(): 0.048%2C (30.25%25 identity in 109 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2910c;product=Conserved hypothetical protein;protein_id=CCP45712.1;transl_table=11
AL123456.3	EMBL	gene	3218339	3219214	.	+	.	ID=gene-Rv2911;Name=dacB2;gbkey=Gene;gene=dacB2;gene_biotype=protein_coding;gene_synonym=dacB;locus_tag=Rv2911
AL123456.3	EMBL	CDS	3218339	3219214	.	+	0	ID=cds-CCP45713.1;Parent=gene-Rv2911;Dbxref=EnsemblGenomes-Gn:Rv2911,EnsemblGenomes-Tr:CCP45713,GOA:I6Y204,InterPro:IPR001967,InterPro:IPR012338,InterPro:IPR018044,UniProtKB/TrEMBL:I6Y204,NCBI_GP:CCP45713.1;Name=CCP45713.1;Note=Rv2911%2C (MTCY274.43)%2C len: 291 aa. Probable dacB2%2CD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein)%2C an ala-rich protein. Highly similar (except in N-terminus) to Q9CCM2|ML0691 putative D-alanyl-D-alanine carboxypeptidase from Mycobacterium leprae (411 aa)%2C FASTA scores: opt: 749%2C E(): 9.3e-39%2C (46.75%25 identity in 276 aa overlap). Also similar to penicillin binding proteins / D-alanyl-D-alanine carboxypeptidases e.g. Q9KCJ8|SC4G1.16c D-alanyl-D-alanine carboxypeptidase from Streptomyces coelicolor (382 aa)%2C FASTA scores: opt: 386%2C E(): 2.1e-16%2C(31.25%25 identity in 285 aa overlap)%3B P35150|DACB_BACSU penicillin-binding protein 5* precursor from Bacillus subtilis (382 aa)%2C FASTA scores: opt: 384%2C E(): 3.6e-17%2C(30.7%25 identity in 244 aa overlap)%3B Q9K8X5|DACB|BH2877 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) from Bacillus halodurans (395 aa)%2C FASTA scores: opt: 359%2C E(): 9.7e-15%2C (30.3%25 identity in 241 aa overlap)%3B P33364|PBP7_ECOLI|PBPG|B2134 penicillin-binding protein 7 precursor from Escherichia coli strain K12 (313 aa)%2C FASTA scores: opt: 273%2C E(): 7.5e-10%2C (27.8%25 identity in 263 aa overlap)%3B etc. Also similar to O53380|Rv3330|MTV016.30 penicillin-binding protein from Mycobacterium tuberculosis (405 aa)%2C FASTA scores: opt: 746%2C E(): 1.4e-38%2C (47.0%25 identity in 266 aa overlap). Seems to contain PF00768 Peptidase_S11 domain PFAM. Belongs to peptidase family S11%3B also known as the D-alanyl-D-alanine carboxypeptidase 1 family. Thought to be a membrane-bound protein. Note that previously known as dacB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dacB2;locus_tag=Rv2911;product=Probable penicillin-binding protein DacB2 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase);protein_id=CCP45713.1;transl_table=11
AL123456.3	EMBL	gene	3219274	3219861	.	-	.	ID=gene-Rv2912c;Name=Rv2912c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2912c
AL123456.3	EMBL	CDS	3219274	3219861	.	-	0	ID=cds-CCP45714.1;Parent=gene-Rv2912c;Dbxref=EnsemblGenomes-Gn:Rv2912c,EnsemblGenomes-Tr:CCP45714,GOA:P9WMC7,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,InterPro:IPR023772,NCBI_GP:CCP45714.1;Name=CCP45714.1;Note=Rv2912c%2C (MTCY274.44c)%2C len: 195 aa. Probable transcription regulatory protein%2C TetR family%2C showing similarity with others e.g. Q9K3V9|SCD10.17 putative TetR-family transcriptional from Streptomyces coelicolor (202 aa)%2C FASTA scores: opt: 185%2C E(): 4.4e-05%2C (31.15%25 identity in 167 aa overlap)%3B Q9KFQ0 TetR-family from Bacillus halodurans (185 aa)%2C FASTA scores: opt: 164%2C E(): 0.001%2C (35.6%25 identity in 73 aa overlap)%3B P17446|BETI_ECOLI|BETI|B0313 regulatory protein from Escherichia coli strain K12 (195 aa)%2C FASTA scores: opt: 126%2C E(): 0.024%2C (24.5%25 identity in 196 aa overlap)%3B etc. Contains possible helix-turn-helix motif at aa 33-54 (+2.71 SD). Possibly belongs to the TetR/AcrR family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2912c;product=Probable transcriptional regulatory protein (probably TetR-family);protein_id=CCP45714.1;transl_table=11
AL123456.3	EMBL	gene	3219863	3221698	.	-	.	ID=gene-Rv2913c;Name=Rv2913c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2913c
AL123456.3	EMBL	CDS	3219863	3221698	.	-	0	ID=cds-CCP45715.1;Parent=gene-Rv2913c;Dbxref=EnsemblGenomes-Gn:Rv2913c,EnsemblGenomes-Tr:CCP45715,GOA:P9WJH9,InterPro:IPR011059,NCBI_GP:CCP45715.1;Name=CCP45715.1;Note=Rv2913c%2C (MTCY338.01c%2C MTCY274.45c)%2C len: 611 aa. Possible D-amino acid aminohydrolase%2C similar (principally in N-terminus) to D-amino acid aminohydrolases e.g. Q9V2D3|NDAD|PAB0090 D-aminoacylase (aspartate%2C glutamate etc) from Pyrococcus abyssi (526 aa)%2C FASTA scores: opt: 336%2C E(): 2.2e-13%2C (27.55%25 identity in 581 aa overlap)%3B P94212|NDDD_ALCXX N-acyl-D-aspartate deacylase (N-acyl-D-aspartate amidohydrolase) from Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans) (498 aa)%2C FASTA scores: opt: 221%2C E(): 3.4e-06%2C (25.95%25 identity in 532 aa overlap)%3B Q9AGH8 D-aminoacylase from Alcaligenes faecalis (484 aa)%2C FASTA scores: opt: 218%2C E(): 5.1e-06%2C(28.35%25 identity in 434 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2913c;product=Possible D-amino acid aminohydrolase (D-amino acid hydrolase);protein_id=CCP45715.1;transl_table=11
AL123456.3	EMBL	gene	3221767	3223524	.	-	.	ID=gene-Rv2914c;Name=pknI;gbkey=Gene;gene=pknI;gene_biotype=protein_coding;locus_tag=Rv2914c
AL123456.3	EMBL	CDS	3221767	3223524	.	-	0	ID=cds-CCP45716.1;Parent=gene-Rv2914c;Dbxref=EnsemblGenomes-Gn:Rv2914c,EnsemblGenomes-Tr:CCP45716,GOA:P9WI69,InterPro:IPR000719,InterPro:IPR011009,NCBI_GP:CCP45716.1;Name=CCP45716.1;Note=Rv2914c%2C (MTCY338.02c)%2C len: 585 aa. Probable pknI%2Ctransmembrane serine/threonine-protein kinase (see citation below)%2C ala-rich protein%2C highly similar to many in Mycobacterium tuberculosis and other bacteria e.g. Q9RLQ7|MBK putative serine/threonine protein kinase from Mycobacterium bovis BCG (291 aa)%2C FASTA scores: opt: 376%2CE(): 1.1e-10%2C (36.95%25 identity in 287 aa overlap)%3B P33973|PKN1_MYXXA serine/threonine-protein kinase from Myxococcus xanthus (693 aa)%2C FASTA scores: opt: 286%2C E(): 5.4e-10%2C (29.9%25 identity in 374 aa overlap)%3B P72003|PKNF_MYCTU|Rv1746|MT1788|MTCY28.09 probable serine/threonine-protein kinase from Mycobacterium tuberculosis (476 aa)%2C FASTA scores: opt: 675%2C E(): 1.7e-24%2C (39.75%25 identity in 468 aa overlap)%3B Q10697|PKNJ_MYCTU|Rv2088|MT2149|MTCY49.28 probable serine/threonine-protein kinase from Mycobacterium tuberculosis (589 aa)%2C FASTA scores: opt: 574%2C E(): 1e-19%2C(34.85%25 identity in 479 aa overlap)%3B etc. Equivalent to AAK47308 from Mycobacterium tuberculosis strain CDC1551 (603 aa) but shorter 18 aa. Contains Hank's kinase subdomain. Belongs to the Ser/Thr family of protein kinases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknI;locus_tag=Rv2914c;product=Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase);protein_id=CCP45716.1;transl_table=11
AL123456.3	EMBL	gene	3223568	3224680	.	-	.	ID=gene-Rv2915c;Name=Rv2915c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2915c
AL123456.3	EMBL	CDS	3223568	3224680	.	-	0	ID=cds-CCP45717.1;Parent=gene-Rv2915c;Dbxref=EnsemblGenomes-Gn:Rv2915c,EnsemblGenomes-Tr:CCP45717,NCBI_GP:CCP45717.1;Name=CCP45717.1;Note=Rv2915c%2C (MTCY338.03c)%2C len: 370 aa. Conserved protein%2C posssibly XAA-pro dipeptidase (prolidase)%2C highly similar to CAC38796|SCI39.08c conserved hypothetical protein from Streptomyces coelicolor (363 aa)%2C FASTA scores: opt: 1341%2C E(): 5.5e-76%2C (56.65%25 identity in 362 aa overlap)%3B and similar to prolidases (XAA-pro dipeptidase) e.g. Q9ABC9|CC0300 putative XAA-pro dipeptidase from Caulobacter crescentus (428 aa)%2C FASTA scores: opt: 327%2CE(): 7.4e-13%2C (30.2%25 identity in 374 aa overlap)%3B Q97XD4 prolidase from Sulfolobus solfataricus (396 aa)%2C FASTA scores: opt: 271%2C E(): 2.1e-09%2C (30.5%25 identity in 354 aa overlap)%3B Q9WX55 prolidase from Microbacterium esteraromaticum (393 aa)%2C FASTA scores: opt: 256%2C E(): 1.8e-08%2C (27.95%25 identity in 365 aa overlap)%3B etc. Also similar to O53619|Rv0074|MTV030.18 conserved hypothetical protein from Mycobacterium tuberculosis (411 aa)%2C FASTA scores: opt: 243%2C E(): 1.2e-07%2C (27.5%25 identity in 389 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2915c;product=Conserved protein;protein_id=CCP45717.1;transl_table=11
AL123456.3	EMBL	gene	3224708	3226285	.	-	.	ID=gene-Rv2916c;Name=ffh;gbkey=Gene;gene=ffh;gene_biotype=protein_coding;locus_tag=Rv2916c
AL123456.3	EMBL	CDS	3224708	3226285	.	-	0	ID=cds-CCP45718.1;Parent=gene-Rv2916c;Dbxref=EnsemblGenomes-Gn:Rv2916c,EnsemblGenomes-Tr:CCP45718,GOA:P9WGD7,InterPro:IPR000897,InterPro:IPR003593,InterPro:IPR004125,InterPro:IPR004780,InterPro:IPR013822,InterPro:IPR022941,InterPro:IPR027417,NCBI_GP:CCP45718.1;Name=CCP45718.1;Note=Rv2916c%2C (MTCY338.04c)%2C len: 525 aa. Probable ffh%2Csignal recognition particle (SRP) protein (ala-%2C gly-%2Cleu-rich protein) (see citation below)%2C equivalent to O33013|SR54_MYCLE signal recognition particle from Mycobacterium leprae (521 aa)%2C FASTA scores: opt: 2968%2CE(): 1.6e-145%2C (87.85%25 identity in 526 aa overlap). Also highly similar to others e.g. O69874|FFH from Streptomyces coelicolor (550 aa)%2C FASTA scores: opt: 2025%2C E(): 6e-97%2C(63.8%25 identity in 519 aa overlap) (N-terminus longer 34 aa)%3B P37105|SR54_BACSU from Bacillus subtilis (446 aa)%2CFASTA scores: opt: 1451%2C E(): 1.9e-67%2C (51.5%25 identity in 435 aa overlap)%3B BAB57399|FFH from Staphylococcus aureus subsp. aureus Mu50 (455 aa)%2C FASTA scores: opt: 1418%2C E(): 9.4e-66%2C (48.65%25 identity in 448 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the SRP family of GTP-binding proteins. Note that signal recognition particle consists of a small cytoplasmic RNA (SC-RNA) molecule and protein FFH. The protein has a two domain structure: the G-domain binds GTP%3B the M-domain binds the RNA and also binds the signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ffh;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2916c;product=Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein);protein_id=CCP45718.1;transl_table=11
AL123456.3	EMBL	gene	3226363	3228243	.	+	.	ID=gene-Rv2917;Name=Rv2917;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2917
AL123456.3	EMBL	CDS	3226363	3228243	.	+	0	ID=cds-CCP45719.1;Parent=gene-Rv2917;Dbxref=EnsemblGenomes-Gn:Rv2917,EnsemblGenomes-Tr:CCP45719,GOA:P9WL21,InterPro:IPR001650,InterPro:IPR003593,InterPro:IPR006935,InterPro:IPR014001,InterPro:IPR027417,NCBI_GP:CCP45719.1;Name=CCP45719.1;Note=Rv2917%2C (MTCY338.05)%2C len: 626 aa. Conserved hypothetical ala-%2C arg-rich protein%2C highly similar (but longer 34 aa) to O33011|ML1624|MLCB250.18C hypothetical 65.2 KDA protein from Mycobacterium leprae (596 aa)%2C FASTA scores: opt: 3117%2C E(): 9e-183%2C (79.8%25 identity in 584 aa overlap). Also highly similar to Q9S2E8|SCE19A.36C hypothetical 66.2 KDA protein from Streptomyces coelicolor (598 aa)%2C FASTA scores: opt: 1921%2C E(): 1.1e-109%2C (56.08%25 identity in 567 aa overlap)%3B and Q9S3Y6|SDRA SDRA protein from Streptomyces coelicolor (597 aa)%2C FASTA scores: opt: 1896%2C E(): 3.6e-108%2C (55.75%25 identity in 567 aa overlap). And shows some similarity with others proteins from other organisms. Equivalent to AAK47311 putative RNA helicase from Mycobacterium tuberculosis strain CDC1551 (602 aa) but longer 24 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2917;product=Conserved hypothetical alanine and arginine rich protein;protein_id=CCP45719.1;transl_table=11
AL123456.3	EMBL	gene	3228254	3230680	.	-	.	ID=gene-Rv2918c;Name=glnD;gbkey=Gene;gene=glnD;gene_biotype=protein_coding;locus_tag=Rv2918c
AL123456.3	EMBL	CDS	3228254	3230680	.	-	0	ID=cds-CCP45720.1;Parent=gene-Rv2918c;Dbxref=EnsemblGenomes-Gn:Rv2918c,EnsemblGenomes-Tr:CCP45720,GOA:P9WN29,InterPro:IPR002912,InterPro:IPR003607,InterPro:IPR006674,InterPro:IPR010043,InterPro:IPR013546,NCBI_GP:CCP45720.1;Name=CCP45720.1;Note=Rv2918c%2C (MTCY338.07c)%2C len: 808 aa. Probable glnD%2Curidylyltransferase (ala-rich protein)%2C similar to other uridylyltransferases e.g. O69873||SC2E1.02 from Streptomyces coelicolor (835 aa)%2C FASTA scores: opt: 1473%2CE(): 2.8e-81%2C (41.03%25 identity in 858 aa overlap)%3B P43919|GLND_HAEIN from Haemophilus influenzae (863 aa)%2CFASTA scores: opt: 333%2C E(): 2.5e-12%2C (25.4%25 identity in 819 aa overlap)%3B P27249|GLND_ECOLI|GLND|B0167 from Escherichia coli strain K12 (890 aa)%2C FASTA scores: opt: 306%2C E(): 1.1e-10%2C (27.75%25 identity in 858 aa overlap)%3B etc. Belongs to the GlnD family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnD;locus_tag=Rv2918c;product=Probable [protein-PII] uridylyltransferase GlnD (PII uridylyl-transferase) (uridylyl removing enzyme) (UTASE);protein_id=CCP45720.1;transl_table=11
AL123456.3	EMBL	gene	3230738	3231076	.	-	.	ID=gene-Rv2919c;Name=glnB;gbkey=Gene;gene=glnB;gene_biotype=protein_coding;locus_tag=Rv2919c
AL123456.3	EMBL	CDS	3230738	3231076	.	-	0	ID=cds-CCP45721.1;Parent=gene-Rv2919c;Dbxref=EnsemblGenomes-Gn:Rv2919c,EnsemblGenomes-Tr:CCP45721,GOA:P9WN31,InterPro:IPR002187,InterPro:IPR002332,InterPro:IPR011322,InterPro:IPR015867,InterPro:IPR017918,PDB:3BZQ,PDB:3LF0,NCBI_GP:CCP45721.1;Name=CCP45721.1;Note=Rv2919c%2C (MTCY338.08c)%2C len: 112 aa. Probable glnB%2Cnitrogen regulatory protein%2C highly similar to others e.g. Q9X705|GLNB PII protein from Corynebacterium glutamicum (Brevibacterium flavum) (112 aa)%2C FASTA scores: opt: 531%2CE(): 4.5e-30%2C (68.75%25 identity in 112 aa overlap)%3B P21193|GLNB_AZOBR nitrogen regulatory protein P-II from Azospirillum brasilense (112 aa)%2C FASTA scores: opt: 496%2CE(): 1.2e-27%2C (60.7%25 identity in 112 aa overlap)%3B P05826|GLNB_ECOLI|B2553|Z3829|ECS3419|STY2808 nitrogen regulatory protein P-II from Escherichia coli strains K12 and O157:H7 (112 aa)%2C FASTA scores: opt: 487%2C E(): 5.3e-27%2C(61.6%25 identity in 112 aa overlap)%3B etc. Contains PS00496 P-II protein urydylation site. Belongs to the P(II) protein family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glnB;inference=protein motif:PROSITE:PS00496;locus_tag=Rv2919c;product=Probable nitrogen regulatory protein P-II GlnB;protein_id=CCP45721.1;transl_table=11
AL123456.3	EMBL	gene	3231073	3232506	.	-	.	ID=gene-Rv2920c;Name=amt;gbkey=Gene;gene=amt;gene_biotype=protein_coding;locus_tag=Rv2920c
AL123456.3	EMBL	CDS	3231073	3232506	.	-	0	ID=cds-CCP45722.1;Parent=gene-Rv2920c;Dbxref=EnsemblGenomes-Gn:Rv2920c,EnsemblGenomes-Tr:CCP45722,GOA:P9WQ65,InterPro:IPR001905,InterPro:IPR018047,InterPro:IPR024041,InterPro:IPR029020,NCBI_GP:CCP45722.1;Name=CCP45722.1;Note=Rv2920c%2C (MTCY338.09c)%2C len: 477 aa. Probable amt%2Cammonium-transport integral membrane protein (ala-%2C gly-%2Cleu-%2C val-rich protein)%2C highly similar to others e.g. Q9ZBP6|SC7A1.27 ammonium transporter from Streptomyces coelicolor (448 aa)%2C FASTA scores: opt: 1246%2C E(): 7.3e-67%2C(54.1%25 identity in 462 aa overlap)%3B P54146|AMT_CORGL ammonium transport system from Corynebacterium glutamicum (452 aa)%2C FASTA scores: opt: 953%2C E(): 2.1e-49%2C (41.45%25 identity in 475 aa overlap)%3B Q07429|NRGA_BACSU probable ammonium transporter (membrane protein NRGA) from Bacillus subtilis (404 aa)%2C FASTA scores: opt: 721%2C E(): 0%2C (44.4%25 identity in 430 aa overlap)%3B etc. Belongs to the AMT1/MEP/NRGA family of ammonium transporters (TC 2.49).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=amt;locus_tag=Rv2920c;product=Probable ammonium-transport integral membrane protein Amt;protein_id=CCP45722.1;transl_table=11
AL123456.3	EMBL	gene	3232871	3234139	.	-	.	ID=gene-Rv2921c;Name=ftsY;gbkey=Gene;gene=ftsY;gene_biotype=protein_coding;locus_tag=Rv2921c
AL123456.3	EMBL	CDS	3232871	3234139	.	-	0	ID=cds-CCP45723.1;Parent=gene-Rv2921c;Dbxref=EnsemblGenomes-Gn:Rv2921c,EnsemblGenomes-Tr:CCP45723,GOA:P9WGD9,InterPro:IPR000897,InterPro:IPR003593,InterPro:IPR004390,InterPro:IPR013822,InterPro:IPR027417,NCBI_GP:CCP45723.1;Name=CCP45723.1;Note=Rv2921c%2C (MTCY338.10c%2C MT2989)%2C len: 422 aa. Probable ftsY%2C signal recognition particle (SRP) receptor%2Ca membrane-associated cell division protein (see citation below)%2C equivalent to O33010|FTSY_MYCLE cell division protein FTSY homolog from Mycobacterium leprae (430 aa)%2CFASTA scores: opt: 1760%2C E(): 1.1e-108%2C (81.35%25 identity in 429 aa overlap). Also similar to others e.g. Q9I6C1|FTSY|PA0373 signal recognition particle receptor FTSY from Pseudomonas aeruginosa (455 aa)%2C FASTA scores: opt: 882%2C E(): 5.1e-40%2C (42.08%25 identity in 385 aa overlap)%3B Q9KVJ6|FTSY cell division protein from Vibrio cholerae (391 aa)%2C FASTA scores: opt: 837%2C E(): 1.2e-37%2C(36.3%25 identity in 394 aa overlap)%3B P10121|FTSY_ECOLI|FTSY|B3464 cell division protein from Escherichia coli strain K12 (497 aa)%2C FASTA scores: opt: 800%2C E(): 1.3e-35%2C (39.75%25 identity in 327 aa overlap)%3B etc. Also similar to Q9ZBP9|SC7A1.24 putative prokaryotic docking protein from Streptomyces coelicolor (412 aa)%2CFASTA scores: opt: 1461%2C E(): 4.3e-71%2C (60.3%25 identity in 423 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00300 SRP54-type proteins GTP-binding domain signature. Belongs to the SRP family of GTP-binding proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ftsY;inference=protein motif:PROSITE:PS00300;locus_tag=Rv2921c;product=Probable cell division protein FtsY (SRP receptor) (signal recognition particle receptor);protein_id=CCP45723.1;transl_table=11
AL123456.3	EMBL	gene	3234189	3237806	.	-	.	ID=gene-Rv2922c;Name=smc;gbkey=Gene;gene=smc;gene_biotype=protein_coding;locus_tag=Rv2922c
AL123456.3	EMBL	CDS	3234189	3237806	.	-	0	ID=cds-CCP45724.1;Parent=gene-Rv2922c;Dbxref=EnsemblGenomes-Gn:Rv2922c,EnsemblGenomes-Tr:CCP45724,GOA:P9WGF3,InterPro:IPR003395,InterPro:IPR010935,InterPro:IPR011890,InterPro:IPR024704,InterPro:IPR027417,NCBI_GP:CCP45724.1;Name=CCP45724.1;Note=Rv2922c%2C (MT2990%2C MTCY338.11c)%2C len: 1205 aa. Probable smc%2C chromosome partition protein (ala-%2C arg-%2Cleu-%2C glu-rich protein%2C possibly coiled-coil protein) (see * below)%2C equivalent (but longer 84 aa) to Q9CBT5|SMC|ML1629|MLCB250.01 possible cell division protein from Mycobacterium leprae (1203 aa)%2C FASTA scores: opt: 5957%2C E(): 0%2C (79.15%25 identity in 1205 aa overlap). Also highly similar to other chromosome segregation proteins e.g. Q9ZBQ2|SC7A1.21 putative chromosome associated protein from Streptomyces coelicolor (1186 aa)%2C FASTA scores: opt: 2633%2C E(): 4.1e-120%2C (53.03%25 identity in 1205 aa overlap)%3B P51834|SMC_BACSU chromosome partition protein from Bacillus subtilis (1186 aa)%2C FASTA scores: opt: 1009%2C E(): 2.1e-41%2C(30.75%25 identity in 1205 aa overlap)%3B Q9CHC9|SMC chromosome segregation protein from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (924 aa)%2C FASTA scores: opt: 996%2CE(): 7.5e-41%2C (29.75%25 identity in 874 aa overlap)%3B etc. Equivalent to AAK47317 from Mycobacterium tuberculosis strain CDC1551 (1205 aa) but longer 84 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the SMC family. N-terminus shortened since first submission. [* Note: Unpublished. Cobbe N.%2C Heck M.M.S.-Phylogenetic analysis of SMC proteins (OCT-2001)].;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=smc;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2922c;product=Probable chromosome partition protein Smc;protein_id=CCP45724.1;transl_table=11
AL123456.3	EMBL	gene	3237818	3238099	.	-	.	ID=gene-Rv2922A;Name=acyP;gbkey=Gene;gene=acyP;gene_biotype=protein_coding;locus_tag=Rv2922A
AL123456.3	EMBL	CDS	3237818	3238099	.	-	0	ID=cds-CCP45725.1;Parent=gene-Rv2922A;Dbxref=EnsemblGenomes-Gn:Rv2922A,EnsemblGenomes-Tr:CCP45725,GOA:P9WQC9,InterPro:IPR001792,InterPro:IPR017968,NCBI_GP:CCP45725.1;Name=CCP45725.1;Note=Rv2922A%2C len: 93 aa. Probable acyP%2C acylphosphatase (acylphosphate phosphohydrolase)%2C highly similar to others e.g. Q9ZBQ3|SC7A1.20 putative acylphosphatase from Streptomyces coelicolor (93 aa)%2C FASTA scores: opt: 345%2CE(): 9.5e-19%2C (58.9%25 identity in 90 aa overlap)%3B P75877|ACYP_ECOLI|YCCX|B0968|Z1320|ECS1052 putative acylphosphatase from Escherichia coli strains K12 and O157:H7 (92 aa)%2C FASTA scores: opt: 220%2C E(): 2e-09%2C(44.95%25 identity in 89 aa overlap)%3B Q9RVU3|DR0929 putative acylphosphatase from Deinococcus radiodurans (87 aa)%2C FASTA scores: opt: 193%2C E(): 2.1e-07%2C (44.3%25 identity in 79 aa overlap)%3B etc. Belongs to the acylphosphatase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=acyP;locus_tag=Rv2922A;product=Probable acylphosphatase AcyP (acylphosphate phosphohydrolase);protein_id=CCP45725.1;transl_table=11
AL123456.3	EMBL	gene	3238086	3238499	.	-	.	ID=gene-Rv2923c;Name=Rv2923c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2923c
AL123456.3	EMBL	CDS	3238086	3238499	.	-	0	ID=cds-CCP45726.1;Parent=gene-Rv2923c;Dbxref=EnsemblGenomes-Gn:Rv2923c,EnsemblGenomes-Tr:CCP45726,GOA:P9WL19,InterPro:IPR003718,InterPro:IPR015946,NCBI_GP:CCP45726.1;Name=CCP45726.1;Note=Rv2923c%2C (MTCY338.12c)%2C len: 137 aa. Conserved protein%2C showing similarity with other hypothetical proteins e.g. P24246|YHFA_ECOLI|B3356|Z4717|ECS4207 from Escherichia coli strains K12 and O157:H7 (134 aa)%2C FASTA scores: opt: 110%2C E(): 1.9%2C (25.9%25 identity in 135 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2923c;product=Conserved protein;protein_id=CCP45726.1;transl_table=11
AL123456.3	EMBL	gene	3238601	3239470	.	-	.	ID=gene-Rv2924c;Name=fpg;gbkey=Gene;gene=fpg;gene_biotype=protein_coding;gene_synonym=mutM;locus_tag=Rv2924c
AL123456.3	EMBL	CDS	3238601	3239470	.	-	0	ID=cds-CCP45727.1;Parent=gene-Rv2924c;Dbxref=EnsemblGenomes-Gn:Rv2924c,EnsemblGenomes-Tr:CCP45727,GOA:P9WNC3,InterPro:IPR000191,InterPro:IPR000214,InterPro:IPR010663,InterPro:IPR010979,InterPro:IPR012319,InterPro:IPR015886,InterPro:IPR015887,InterPro:IPR020629,NCBI_GP:CCP45727.1;Name=CCP45727.1;Note=Rv2924c%2C (MTCY338.13c)%2C len: 289 aa. Probable fpg (alternate gene name: mutM)%2C formamidopyrimidine-DNA glycosylase (see citation below)%2C equivalent to O69470|FPG_MYCLE formamidopyrimidine-DNA glycosylase from Mycobacterium leprae (282 aa)%2C FASTA scores: opt: 1563%2CE(): 1.3e-96%2C (80.6%25 identity in 289 aa overlap). Also highly similar to other formamidopyrimidine-DNA glycosylases e.g. Q9ZBQ6|FPG_STRCO from Streptomyces coelicolor (286 aa)%2C FASTA scores: opt: 1047%2C E(): 2.9e-62%2C(57.55%25 identity in 292 aa overlap)%3B P95744|FPG_SYNEN from Synechococcus elongatus naegeli (284 aa)%2C FASTA scores: opt: 569%2C E(): 1.9e-30%2C (37.95%25 identity in 290 aa overlap)%3B P05523|FPG_ECOLI|MUTM|FPG|B3635 from Escherichia coli strain K12 (269 aa)%2C FASTA scores: opt: 424%2C E(): 8.2e-21%2C (33.9%25 identity in 289 aa overlap)%3B etc. Belongs to the FPG family. Cofactor: binds 1 zinc ion.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fpg;locus_tag=Rv2924c;product=Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase);protein_id=CCP45727.1;transl_table=11
AL123456.3	EMBL	gene	3239829	3240551	.	-	.	ID=gene-Rv2925c;Name=rnc;gbkey=Gene;gene=rnc;gene_biotype=protein_coding;locus_tag=Rv2925c
AL123456.3	EMBL	CDS	3239829	3240551	.	-	0	ID=cds-CCP45728.1;Parent=gene-Rv2925c;Dbxref=EnsemblGenomes-Gn:Rv2925c,EnsemblGenomes-Tr:CCP45728,GOA:P9WH03,InterPro:IPR000999,InterPro:IPR011907,InterPro:IPR014720,PDB:2A11,NCBI_GP:CCP45728.1;Name=CCP45728.1;Note=Rv2925c%2C (MTCY338.14c)%2C len: 240 aa. Probable rnc%2Cribonuclease III (RNase III)%2C equivalent to O69469|RNC_MYCLE ribonuclease III from Mycobacterium leprae (238 aa). Also highly similar to other ribonucleases III e.g. Q9ZBQ7|RNC_STRCO from Streptomyces coelicolor (272 aa)%2C FASTA scores: opt: 889%2C E(): 5.4e-51%2C (62.2%25 identity in 225 aa overlap) (N-terminus longer 21 aa)%3B P51833|RNC_BACSU from Bacillus subtilis (249 aa)%2C FASTA scores: opt: 493%2C E(): 5e-25%2C (43.25%25 identity in 215 aa overlap)%3B P05797|RNC_ECOLI|RNC|B2567|Z3848|ECS3433 from Escherichia coli strain O157:H7 and K12 (226 aa)%2C FASTA scores: opt: 459%2C E(): 7.9e-23%2C (41.8%25 identity in 213 aa overlap)%3B etc. Contains PS00517 Ribonuclease III family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rnc;inference=protein motif:PROSITE:PS00517;locus_tag=Rv2925c;product=Probable ribonuclease III Rnc (RNase III);protein_id=CCP45728.1;transl_table=11
AL123456.3	EMBL	gene	3240548	3241171	.	-	.	ID=gene-Rv2926c;Name=Rv2926c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2926c
AL123456.3	EMBL	CDS	3240548	3241171	.	-	0	ID=cds-CCP45729.1;Parent=gene-Rv2926c;Dbxref=EnsemblGenomes-Gn:Rv2926c,EnsemblGenomes-Tr:CCP45729,GOA:P9WL17,InterPro:IPR003772,NCBI_GP:CCP45729.1;Name=CCP45729.1;Note=Rv2926c%2C (MTCY338.15c)%2C len: 207 aa. Conserved protein%2C equivalent to O69468|ML1660|MLCB1243.14 hypothetical 23.5 KDA protein from Mycobacterium leprae (217 aa)%2C FASTA scores: opt: 866%2C E(): 1.4e-48%2C (67.2%25 identity in 192 aa overlap). Also similar in part to other hypothetical proteins e.g. Q9WXZ8 conserved hypothetical protein from Thermotoga maritima (182 aa)%2C FASTA scores: opt: 254%2C E(): 3.4e-09%2C (31.45%25 identity in 143 aa overlap)%3B Q9ZBQ9|SC7A1.14 hypothetical 23.5 KDA protein from Streptomyces coelicolor (217 aa)%2C FASTA scores: opt: 244%2C E(): 1.7e-08%2C (45.5%25 identity in 189 aa overlap)%3B O65982 hypothetical 26.2 KDA protein from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (228 aa)%2C FASTA scores: opt: 220%2CE(): 6.1e-07%2C (32.45%25 identity in 148 aa overlap)%3B etc. Equivalent to AAK47323 from Mycobacterium tuberculosis strain CDC1551 (195 aa) but longer 12 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2926c;product=Conserved protein;protein_id=CCP45729.1;transl_table=11
AL123456.3	EMBL	gene	3241222	3241959	.	-	.	ID=gene-Rv2927c;Name=Rv2927c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2927c
AL123456.3	EMBL	CDS	3241222	3241959	.	-	0	ID=cds-CCP45730.1;Parent=gene-Rv2927c;Dbxref=EnsemblGenomes-Gn:Rv2927c,EnsemblGenomes-Tr:CCP45730,GOA:P9WL15,InterPro:IPR028987,NCBI_GP:CCP45730.1;Name=CCP45730.1;Note=Rv2927c%2C (MTCY338.16c)%2C len: 245 aa. Conserved hypothetical protein%2C equivalent to Q9CBS6|ML1661|MLCB1243.13 (alias O69467) hypothetical protein from Mycobacterium leprae (247 aa)%2C FASTA scores: opt: 1440%2C E(): 4.9e-76%2C (90.6%25 identity in 245 aa overlap). Also similar to many hypothetical proteins from other organisms e.g. Q9ZBR0|SC7A1.13 hypothetical 41.0 KDA protein from Streptomyces coelicolor (379 aa)%2C FASTA scores: opt: 266%2C E(): 3.4e-08%2C (29.9%25 identity in 234 aa overlap)%3B etc. Also some similarity with P46815|AG84_MYCLE|ML0922 antigen 84 from Mycobacterium leprae (266 aa)%2C FASTA scores: opt: 193%2C E(): 0.00043%2C(28.7%25 identity in 136 aa overlap) (see citation below)%3B and P46816|AG84_MYCTU|WAG31|Rv2145c|MT2204|MTCY270.23 antigen 84 from Mycobacterium tuberculosis (260 aa)%2C FASTA scores: opt: 178%2C E(): 0.0031%2C (34.35%25 identity in 131 aa overlap) (see citation below). Contains potential coiled-coil region.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2927c;product=Conserved hypothetical protein;protein_id=CCP45730.1;transl_table=11
AL123456.3	EMBL	gene	3242198	3242983	.	+	.	ID=gene-Rv2928;Name=tesA;gbkey=Gene;gene=tesA;gene_biotype=protein_coding;locus_tag=Rv2928
AL123456.3	EMBL	CDS	3242198	3242983	.	+	0	ID=cds-CCP45731.1;Parent=gene-Rv2928;Dbxref=EnsemblGenomes-Gn:Rv2928,EnsemblGenomes-Tr:CCP45731,GOA:P9WQD5,InterPro:IPR001031,InterPro:IPR012223,InterPro:IPR029058,NCBI_GP:CCP45731.1;Name=CCP45731.1;Note=Rv2928%2C (MTCY338.17)%2C len: 261 aa. Probable tesA%2Cthioesterase%2C similar to many e.g. Q9L4W2|NYSE thioesterase involved in synthesis of the polyene antifungal antibiotic nystatin from Streptomyces noursei (see Brautaset et al.%2C2000) (251 aa). TesA|Rv2928 interacts with PpsE|Rv2935%2C by bacterial two-hybrid and GST-pulldown assays (See Rao and Ranganathan%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tesA;locus_tag=Rv2928;product=Probable thioesterase TesA;protein_id=CCP45731.1;transl_table=11
AL123456.3	EMBL	gene	3242970	3243281	.	+	.	ID=gene-Rv2929;Name=Rv2929;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2929
AL123456.3	EMBL	CDS	3242970	3243281	.	+	0	ID=cds-CCP45732.1;Parent=gene-Rv2929;Dbxref=EnsemblGenomes-Gn:Rv2929,EnsemblGenomes-Tr:CCP45732,GOA:P9WL13,NCBI_GP:CCP45732.1;Name=CCP45732.1;Note=Rv2929%2C (MTCY338.18)%2C len: 103 aa. Hypothetical unknown protein%3B some weak similarity to C-terminal half of P18319|UREG_KLEAE urease accessory protein from klebsiella aerogenes (205 aa)%2C FASTA scores: opt: 99%2C E(): 1.1%2C (38.6%25 identity in 57 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv2929;product=Hypothetical protein;protein_id=CCP45732.1;transl_table=11
AL123456.3	EMBL	gene	3243697	3245448	.	+	.	ID=gene-Rv2930;Name=fadD26;gbkey=Gene;gene=fadD26;gene_biotype=protein_coding;locus_tag=Rv2930
AL123456.3	EMBL	CDS	3243697	3245448	.	+	0	ID=cds-CCP45733.1;Parent=gene-Rv2930;Dbxref=EnsemblGenomes-Gn:Rv2930,EnsemblGenomes-Tr:CCP45733,GOA:P9WQ43,InterPro:IPR000873,NCBI_GP:CCP45733.1;Name=CCP45733.1;Note=Rv2930%2C (MT2999%2C MTCY338.19)%2C len: 583 aa. FadD26%2Cfatty-acid-AMP synthetase%2C equivalent to Q9Z5K5|FADD26|ML2358|MLCB12.03c probable acyl-CoA synthase from Mycobacterium leprae (583 aa)%2C FASTA scores: opt: 3026%2C E(): 9.2e-180%2C (76.85%25 identity in 583 aa overlap). Also highly similar to many e.g. Q9CD84|ML0132 putative acyl-CoA synthetase from Mycobacterium leprae (680 aa)%2CFASTA scores: opt: 2324%2C E(): 3.2e-136%2C (61.35%25 identity in 572 aa overlap)%3B P71495 acyl-CoA synthase from Mycobacterium bovis (582 aa)%2C FASTA scores: opt: 2304%2C E(): 5e-135%2C (59.85%25 identity in 583 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50586|FD25_MYCTU|RV1521|MTCY19G5.07 putative fatty-acid--CoA ligase (583 aa)%2C FASTA scores: opt: 2188%2CE(): 7.6e-128%2C (57.55%25 identity in 584 aa overlap)%3B etc. Belongs to the ATP-dependent AMP-binding enzyme family. N-terminus shortened since first submission. Note that Rv2930|fadD26 belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD26;locus_tag=Rv2930;product=Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP45733.1;transl_table=11
AL123456.3	EMBL	gene	3245445	3251075	.	+	.	ID=gene-Rv2931;Name=ppsA;gbkey=Gene;gene=ppsA;gene_biotype=protein_coding;locus_tag=Rv2931
AL123456.3	EMBL	CDS	3245445	3251075	.	+	0	ID=cds-CCP45734.1;Parent=gene-Rv2931;Dbxref=EnsemblGenomes-Gn:Rv2931,EnsemblGenomes-Tr:CCP45734,GOA:P9WQE7,InterPro:IPR001227,InterPro:IPR002198,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR020841,InterPro:IPR020842,NCBI_GP:CCP45734.1;Name=CCP45734.1;Note=Rv2931%2C (MTCY338.20)%2C len: 1876 aa. PpsA%2C type-I polyketide synthase (see citations below)%2C highly similar to others from Mycobacterium leprae e.g. Q9Z5K6|ML2357|MLCB12.02c putative polyketide synthase from Mycobacterium leprae (1871 aa)%2C FASTA scores: opt: 7566%2CE(): 0%2C (76.1%25 identity in 1888 aa overlap)%3B Q9S384|ML2356|MLCB12.01c putative polyketide synthase from Mycobacterium leprae (1540 aa)%2C FASTA scores: opt: 4026%2CE(): 9.8e-212%2C (45.7%25 identity in 1811 aa overlap)%3B Q49932|PKSC|L518_F1_2 putative polyketide synthase (1446 aa)%2C FASTA scores: opt: 4026%2C E(): 9.4e-212%2C (70.6%25 identity in 885 aa overlap). Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7|EPOC polyketide synthase from Polyangium cellulosum (7257 aa)%2C FASTA scores: opt: 2592%2C E(): 5.2e-133%2C (32.55%25 identity in 2245 aa overlap)%3B P22367|MSAS_PENPA 6-methylsalicylic acid synthase from Penicillium patulum (Penicillium griseofulvum) (1774 aa)%2C FASTA scores: opt: 2391%2C E(): 0%2C (34.2%25 identity in 1815 aa overlap)%3B etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 phenolpthiocerol synthesis polyketide synthase (1538 aa)%2C FASTA scores: opt: 4227%2C E(): 0%2C (46.8%25 identity in 1810 aa overlap) (gap in middle)%3B etc. Contains PS00606 Beta-ketoacyl synthases active site%2C and PS00012 Phosphopantetheine attachment site. Note that Rv2931|ppsA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppsA;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2931;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsA;protein_id=CCP45734.1;transl_table=11
AL123456.3	EMBL	gene	3251072	3255688	.	+	.	ID=gene-Rv2932;Name=ppsB;gbkey=Gene;gene=ppsB;gene_biotype=protein_coding;locus_tag=Rv2932
AL123456.3	EMBL	CDS	3251072	3255688	.	+	0	ID=cds-CCP45735.1;Parent=gene-Rv2932;Dbxref=EnsemblGenomes-Gn:Rv2932,EnsemblGenomes-Tr:CCP45735,GOA:P9WQE5,InterPro:IPR001227,InterPro:IPR009081,InterPro:IPR013968,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR020841,NCBI_GP:CCP45735.1;Name=CCP45735.1;Note=Rv2932%2C (MTV011.01%2C MTCY338.21%2C MT3002)%2C len: 1538 aa. PpsB%2C type-I polyketide synthase (see citations below)%2Chighly similar to others from Mycobacterium leprae e.g. Q9S384|ML2356|MLCB12.01c putative polyketide synthase (1540 aa)%2C FASTA scores: opt: 7284%2C E(): 0%2C (76.3%25 identity in 1561 aa overlap)%3B Q49932|PKSC|L518_F1_2 putative polyketide synthase (1446 aa)%2C FASTA scores: opt: 6811%2C E(): 0%2C (76.2%25 identity in 1462 aa overlap)%3B etc. Also similar to polyketide synthases from other bacteria e.g. Q9KIZ6|EPOE EPOE protein from Polyangium cellulosum (3798 aa)%2C FASTA scores: opt: 3052%2C E(): 3.3e-165%2C (38.35%25 identity in 1538 aa overlap)%3B etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10977|PPSA_MYCTU|RV2931 phenolpthiocerol synthesis polyketide synthase (1876 aa)%2CFASTA scores: opt: 4227%2C E(): 0%2C (46.9%25 identity in 1810 aa overlap)%3B P96203|PPSD|Rv2934|MTCY19H9.02 PKSE protein (1827 aa)%2C FASTA scores: opt: 3756%2C E(): 1.8e-205%2C (42.9%25 identity in 1808 aa overlap)%3B etc. Overlaps and extends CDS from neighbouring cosmid MTCY338.21. Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2932|ppsB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally). Nucleotide position 3254365 in the genome sequence has been corrected%2C T:C resulting in L1098L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppsB;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2932;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsB;protein_id=CCP45735.1;transl_table=11
AL123456.3	EMBL	gene	3255685	3262251	.	+	.	ID=gene-Rv2933;Name=ppsC;gbkey=Gene;gene=ppsC;gene_biotype=protein_coding;locus_tag=Rv2933
AL123456.3	EMBL	CDS	3255685	3262251	.	+	0	ID=cds-CCP45736.1;Parent=gene-Rv2933;Dbxref=EnsemblGenomes-Gn:Rv2933,EnsemblGenomes-Tr:CCP45736,GOA:P96202,InterPro:IPR001227,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR013968,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR020807,InterPro:IPR020841,InterPro:IPR020842,InterPro:IPR020843,PDB:1PQW,NCBI_GP:CCP45736.1;Name=CCP45736.1;Note=Rv2933%2C (MTCY19H9.01%2C MTV011.02)%2C len: 2188 aa. ppsC%2C type-I polyketide synthase (see citations below)%2Chighly similar to others from Mycobacterium leprae e.g. Q49933|PKSD|ML2355|L518_F1_3 putative polyketide synthase (2201 aa)%2C FASTA scores: opt: 6973%2C E(): 0%2C (82.32%25 identity in 2217 aa overlap)%3B Q49624|PKS3|MASA|ML1229|B1170_C2_209 probable mycocerosic acid synthase (2118 aa)%2C FASTA scores: opt: 4015%2C E(): 2.9e-208%2C (36.6%25 identity in 2184 aa overlap)%3B etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9L8C7 polyketide synthase from Polyangium cellulosum (7257 aa)%2C FASTA scores: opt: 3909%2C E(): 3.6e-202%2C (40.15%25 identity in 2220 aa overlap)%3B Q9KIZ7|EPOD EPOD protein from Polyangium cellulosum (7257 aa)%2C FASTA scores: opt: 3886%2C E(): 6.2e-201%2C (40.05%25 identity in 2220 aa overlap)%3B etc. And also highly similar to others from Mycobacterium tuberculosis e.g. P96291|Rv2940c (2111 aa)%2CFASTA scores: opt: 4204%2C E(): 0%2C (39.1%25 identity in 2176 aa overlap)%3B Q10977|PPSA_MYCTU|RV2931 phenolpthiocerol synthesis polyketide synthase (1876 aa)%2C FASTA scores: opt: 3793%2C E(): 2.4e-196%2C (46.65%25 identity in 1612 aa overlap)%3B etc. Contains PS00606 Beta-ketoacyl synthases active site%2Cand PS00012 Phosphopantetheine attachment site. Note that Rv2933|ppsC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppsC;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2933;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsC;protein_id=CCP45736.1;transl_table=11
AL123456.3	EMBL	gene	3262248	3267731	.	+	.	ID=gene-Rv2934;Name=ppsD;gbkey=Gene;gene=ppsD;gene_biotype=protein_coding;locus_tag=Rv2934
AL123456.3	EMBL	CDS	3262248	3267731	.	+	0	ID=cds-CCP45737.1;Parent=gene-Rv2934;Dbxref=EnsemblGenomes-Gn:Rv2934,EnsemblGenomes-Tr:CCP45737,GOA:P9WQE3,InterPro:IPR001227,InterPro:IPR002198,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR020807,InterPro:IPR020841,InterPro:IPR020842,NCBI_GP:CCP45737.1;Name=CCP45737.1;Note=Rv2934%2C (MTCY19H9.02)%2C len: 1827 aa. PpsD%2C type-I polyketide synthase (see citations below)%2C highly similar to others from Mycobacterium leprae e.g. Q9CB70|ML2354 polyketide synthase (1822 aa)%2C FASTA scores: opt: 9779%2CE(): 0%2C (80.35%25 identity in 1836 aa overlap)%3B Q49940|L518_F3_67|PFSE (1815 aa)%2C FASTA scores: opt: 9658%2CE(): 0%2C (79.85%25 identity in 1831 aa overlap)%3B etc. Also similar to polyketide synthases from other bacteria e.g. C-terminus of Q9RNB2|MCYD|Q9FDU1 polyketide synthase (MCYD protein) from Microcystis aeruginosa (3906 aa)%2C FASTA scores: opt: 2961%2C E(): 6e-159%2C (32.15%25 identity in 1827 aa overlap)%3B etc. And also highly similar to others from Mycobacterium tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932 phenolpthiocerol synthesis polyketide synthase (1538 aa)%2CFASTA scores: opt: 3756%2C E(): 3.8e-204%2C (42.85%25 identity in 1808 aa overlap) (gaps in middle)%3B P96202|PPSC|RV2933 polyketide synthase (2188 aa)%2C FASTA scores: opt: 3463%2CE(): 1.7e-187%2C (39.2%25 identity in 2165 aa overlap)%3B etc. Contains PS00606 Beta-ketoacyl synthases active site%2CPS00017 ATP/GTP-binding site motif A%2C PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C and PS00012 Phosphopantetheine attachment site. Note that Rv2934|ppsD belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppsD;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2934;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsD;protein_id=CCP45737.1;transl_table=11
AL123456.3	EMBL	gene	3267737	3272203	.	+	.	ID=gene-Rv2935;Name=ppsE;gbkey=Gene;gene=ppsE;gene_biotype=protein_coding;locus_tag=Rv2935
AL123456.3	EMBL	CDS	3267737	3272203	.	+	0	ID=cds-CCP45738.1;Parent=gene-Rv2935;Dbxref=EnsemblGenomes-Gn:Rv2935,EnsemblGenomes-Tr:CCP45738,GOA:P9WQE1,InterPro:IPR001227,InterPro:IPR001242,InterPro:IPR009081,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR018201,InterPro:IPR020801,NCBI_GP:CCP45738.1;Name=CCP45738.1;Note=Rv2935%2C (MTCY19H9.03)%2C len: 1488 aa. PpsE%2C type-I polyketide synthase (see citations below). Contains PS00606 Beta-ketoacyl synthases active site. Note that Rv2935|ppsE belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally). TesA|Rv2928 interacts with PpsE|Rv2935%2C by bacterial two-hybrid and GST-pulldown assays (See Rao and Ranganathan%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppsE;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2935;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsE;protein_id=CCP45738.1;transl_table=11
AL123456.3	EMBL	gene	3272214	3273209	.	+	.	ID=gene-Rv2936;Name=drrA;gbkey=Gene;gene=drrA;gene_biotype=protein_coding;locus_tag=Rv2936
AL123456.3	EMBL	CDS	3272214	3273209	.	+	0	ID=cds-CCP45739.1;Parent=gene-Rv2936;Dbxref=EnsemblGenomes-Gn:Rv2936,EnsemblGenomes-Tr:CCP45739,GOA:P9WQL9,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR005894,InterPro:IPR017871,InterPro:IPR027417,NCBI_GP:CCP45739.1;Name=CCP45739.1;Note=Rv2936%2C (MTCY19H9.04)%2C len: 331 aa. drrA%2Cdaunorubicin-dim-transport resistance ATP-binding protein ABC transporter%2C probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below)%2C equivalent to Q49938|DRRA|ML2352|L518_F2_43|DRRA probable daunorubicin resistance ATP-binding protein from Mycobacterium leprae (331 aa)%2C FASTA scores: opt: 1842%2C E(): 4.2e-103%2C (85.2%25 identity in 331 aa overlap). Also highly similar to others e.g. Q9XCF7 DRRA from Mycobacterium avium (315 aa)%2C FASTA scores: opt: 1040%2C E(): 4.7e-55%2C (54.35%25 identity in 309 aa overlap)%3B Q9X5J8 daunorubicin resistance protein A from Mycobacterium avium (315 aa)%2C FASTA scores: opt: 1030%2C E(): 1.9e-54%2C (53.7%25 identity in 309 aa overlap)%3B P32010|DRRA_STRPE daunorubicin resistance ATP-binding protein from Streptomyces peucetius (330 aa)%2C FASTA scores: opt: 852%2C E(): 9e-44%2C (47.15%25 identity in 318 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters). Note that Rv2936|drrA belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=drrA;inference=protein motif:PROSITE:PS00211;locus_tag=Rv2936;product=Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA;protein_id=CCP45739.1;transl_table=11
AL123456.3	EMBL	gene	3273206	3274075	.	+	.	ID=gene-Rv2937;Name=drrB;gbkey=Gene;gene=drrB;gene_biotype=protein_coding;locus_tag=Rv2937
AL123456.3	EMBL	CDS	3273206	3274075	.	+	0	ID=cds-CCP45740.1;Parent=gene-Rv2937;Dbxref=EnsemblGenomes-Gn:Rv2937,EnsemblGenomes-Tr:CCP45740,GOA:P9WG23,InterPro:IPR000412,InterPro:IPR004377,NCBI_GP:CCP45740.1;Name=CCP45740.1;Note=Rv2937%2C (MTCY19H9.05)%2C len: 289 aa. drrB%2Cdaunorubicin-dim-transport integral membrane protein ABC transporter%2C probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below)%2C equivalent to Q49935|DRRB|ML2351|L518_F1_9 daunorubicin resistance transmembrane protein from Mycobacterium leprae (288 aa)%2C FASTA scores: opt: 1252%2CE(): 5.3e-72%2C (64.0%25 identity in 289 aa overlap). Also similar to others e.g. Q9XCF8 DRRB protein from Mycobacterium avium (246 aa)%2C FASTA scores: opt: 423%2C E(): 1.5e-19%2C (30.85%25 identity in 243 aa overlap)%3B Q9S6H4 daunorubicin resistance protein B from Mycobacterium avium (246 aa)%2C FASTA scores: opt: 420%2C E(): 2.3e-19%2C (30.85%25 identity in 243 aa overlap)%3B P32011|DRRB_STRPE daunorubicin resistance transmembrane protein from Streptomyces peucetius (283 aa)%2C FASTA scores: opt: 242%2C E(): 4.7e-08%2C(27.85%25 identity in 219 aa overlap)%3B etc. Note that Rv293|drrB belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=drrB;locus_tag=Rv2937;product=Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB;protein_id=CCP45740.1;transl_table=11
AL123456.3	EMBL	gene	3274072	3274902	.	+	.	ID=gene-Rv2938;Name=drrC;gbkey=Gene;gene=drrC;gene_biotype=protein_coding;locus_tag=Rv2938
AL123456.3	EMBL	CDS	3274072	3274902	.	+	0	ID=cds-CCP45741.1;Parent=gene-Rv2938;Dbxref=EnsemblGenomes-Gn:Rv2938,EnsemblGenomes-Tr:CCP45741,GOA:P9WG21,InterPro:IPR000412,InterPro:IPR004377,InterPro:IPR005943,InterPro:IPR013525,NCBI_GP:CCP45741.1;Name=CCP45741.1;Note=Rv2938%2C (MTCY19H9.06)%2C len: 276 aa. Probable drrC%2Cdaunorubicin-dim-transport integral membrane protein ABC transporter%2C probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below)%2C equivalent to Q9CB71|ML2350 probable antibiotic resistance membrane protein from Mycobacterium leprae (276 aa)%2C FASTA scores: opt: 1434%2C E(): 1.2e-81%2C (79.0%25 identity in 276 aa overlap)%3B and Q49941|DRRC|L518_F3_76 putative daunorubicin resistance transmembrane protein from Mycobacterium leprae (244 aa)%2C FASTA scores: opt: 1194%2CE(): 8.3e-67%2C (76.85%25 identity in 242 aa overlap). Also similar to others e.g. Q9XCF9 DRRC protein from Mycobacterium avium (263 aa)%2C FASTA scores: opt: 538%2C E(): 3.7e-26%2C (32.65%25 identity in 251 aa overlap)%3B Q9S6H3 daunorubicin resistance protein C from Mycobacterium avium (263 aa)%2C FASTA scores: opt: 533%2C E(): 7.6e-26%2C (32.25%25 identity in 251 aa overlap)%3B P32011|DRRB_STRPE daunorubicin resistance transmembrane protein from Streptomyces peucetius (283 aa)%2C FASTA scores: opt: 276%2C E(): 6.6e-10%2C(21.07%25 identity in 261 aa overlap)%3B etc. Note that Rv2938|drrC belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=drrC;locus_tag=Rv2938;product=Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC;protein_id=CCP45741.1;transl_table=11
AL123456.3	EMBL	gene	3274949	3276217	.	+	.	ID=gene-Rv2939;Name=papA5;gbkey=Gene;gene=papA5;gene_biotype=protein_coding;locus_tag=Rv2939
AL123456.3	EMBL	CDS	3274949	3276217	.	+	0	ID=cds-CCP45742.1;Parent=gene-Rv2939;Dbxref=EnsemblGenomes-Gn:Rv2939,EnsemblGenomes-Tr:CCP45742,GOA:P9WIN5,InterPro:IPR001242,PDB:1Q9J,NCBI_GP:CCP45742.1;Name=CCP45742.1;Note=Rv2939%2C (MTCY19H9.07)%2C len: 422 aa. Possible papA5%2Cconserved polyketide synthase (PKS) associated protein (see Camacho et al.%2C 2001)%2C equivalent to Q49939 hypothetical 45.6 KDA protein from Mycobacterium leprae (423 aa)%2C FASTA scores: opt: 2398%2C E(): 4.5e-144%2C (84.05%25 identity in 426 aa overlap)%3B and Q02279|YMA3_MYCBO hypothetical 38.1 KDA protein from Mycobacterium bovis (354 aa)%2C FASTA scores: opt: 2193%2C E(): 3.6e-131%2C (97.4%25 identity in 343 aa overlap). And C-terminus highly similar to to Q9S381 hypothetical 5.0 KDA protein (fragment) from Mycobacterium leprae (44 aa)%2C FASTA scores: opt: 275%2C E(): 1.4e-10%2C(88.65%25 identity in 44 aa overlap). Also similar in part to various synthetases e.g. Q9AE01|RIF20 RIF20 protein from Amycolatopsis mediterranei (Nocardia mediterranei) (403 aa)%2C FASTA scores: opt: 282%2C E(): 2.7e-10%2C (30.3%25 identity in 393 aa overlap)%3B middle part of Q00869|ESYN1 enniatin sythetase (fragment) (N-methyl peptide synthetase) from Fusarium equiseti (3131 aa)%2C FASTA scores: opt: 180%2C E(): 0.0036%2C (26.85%25 identity in 242 aa overlap)%3B N-terminus of Q9FB18 peptide synthetase NRPS2-1 from Streptomyces verticillus (2626 aa)%2C FASTA scores: opt: 159%2C E(): 0.068%2C(23.65%25 identity in 351 aa overlap)%3B etc. Note that Rv2939|papA5 belongs to the transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=papA5;locus_tag=Rv2939;product=Possible conserved polyketide synthase associated protein PapA5;protein_id=CCP45742.1;transl_table=11
AL123456.3	EMBL	gene	3276380	3282715	.	-	.	ID=gene-Rv2940c;Name=mas;gbkey=Gene;gene=mas;gene_biotype=protein_coding;locus_tag=Rv2940c
AL123456.3	EMBL	CDS	3276380	3282715	.	-	0	ID=cds-CCP45743.1;Parent=gene-Rv2940c;Dbxref=EnsemblGenomes-Gn:Rv2940c,EnsemblGenomes-Tr:CCP45743,GOA:I6Y231,InterPro:IPR001227,InterPro:IPR002198,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020807,InterPro:IPR020841,InterPro:IPR020842,InterPro:IPR020843,UniProtKB/TrEMBL:I6Y231,NCBI_GP:CCP45743.1;Name=CCP45743.1;Note=Rv2940c%2C (MTCY24G1.09%2C MTCY19H9.08c)%2C len: 2111 aa. Probable mas%2C mycocerosic acid synthase membrane associated%2C multifunctional enzyme (see citations below)%2Calmost identical to Q02251|MCAS_MYCBO|mas mycocerosic acid synthase from Mycobacterium bovis (2110 aa)%2C FASTA scores: opt: 13226%2C E(): 0%2C (95.8%25 identity in 2115 aa overlap) (see Mathur %26 Kolattukudy 1992)%3B and equivalent to Q9CD78|mas|ML0139 putative mycocerosic synthase from Mycobacterium leprae (2116 aa)%2C FASTA scores: opt: 12142%2CE(): 0%2C (87.95%25 identity in 2119 aa overlap)%3B and Q49624|PKS3|MASA|ML1229|B1170_C2_209 probable mycocerosic acid synthase from Mycobacterium leprae (2118 aa)%2C FASTA scores: opt: 8421%2C E(): 0%2C (60.8%25 identity in 2127 aa overlap). Also similar to other synthases e.g. C-terminus of Q9L8C7|EPOC polyketide synthase from Polyangium cellulosum (7257 aa)%2C FASTA scores: opt: 4332%2C E(): 0%2C(40.85%25 identity in 2149 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 polyketide synthase (2108 aa)%2C FASTA scores: opt: 5059%2C E(): 0%2C (65.9%25 identity in 2121 aa overlap)%3B etc. Contains several domains%2C organized in the following order: beta-ketoacyl synthase (PS00606)%2C acyl transferase%2C dehydratase-enoyl reductase%2C beta-ketoreductase%2C acyl carrier protein. Contains PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mas;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2940c;product=Probable multifunctional mycocerosic acid synthase membrane-associated Mas;protein_id=CCP45743.1;transl_table=11
AL123456.3	EMBL	gene	3283335	3285077	.	+	.	ID=gene-Rv2941;Name=fadD28;gbkey=Gene;gene=fadD28;gene_biotype=protein_coding;gene_synonym=acoas;locus_tag=Rv2941
AL123456.3	EMBL	CDS	3283335	3285077	.	+	0	ID=cds-CCP45744.1;Parent=gene-Rv2941;Dbxref=EnsemblGenomes-Gn:Rv2941,EnsemblGenomes-Tr:CCP45744,GOA:P9WQ59,InterPro:IPR000873,PDB:3E53,PDB:3T5A,NCBI_GP:CCP45744.1;Name=CCP45744.1;Note=Rv2941%2C (MTCY24G1.08c)%2C len: 580 aa. FadD28 (alternate gene name: acoas)%2C fatty-acid-AMP synthetase (see citations below)%2C almost identical to P71495 acyl-CoA synthase from Mycobacterium bovis (582 aa)%2C FASTA scores: opt: 3828%2C E(): 0%2C (99.15%25 identity in 580 aa overlap)%3B and equivalent to Q9CD79|FADD28|ML0138 acyl-CoA synthetase from Mycobacterium leprae (579 aa)%2C FASTA scores: opt: 3183%2CE(): 8.8e-186%2C (81.9%25 identity in 580 aa overlap). And also highly similar to others Mycobacteria proteins e.g. O07797|FADD23|Rv3826|MTCY409.04c putative fatty-acid-CoA synthetase from Mycobacterium tuberculosis (584 aa)%3B etc. Contains PS00018 EF-hand calcium-binding domain. Note that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally coupled (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD28;inference=protein motif:PROSITE:PS00018;locus_tag=Rv2941;product=Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP45744.1;transl_table=11
AL123456.3	EMBL	gene	3285070	3287832	.	+	.	ID=gene-Rv2942;Name=mmpL7;gbkey=Gene;gene=mmpL7;gene_biotype=protein_coding;locus_tag=Rv2942
AL123456.3	EMBL	CDS	3285070	3287832	.	+	0	ID=cds-CCP45745.1;Parent=gene-Rv2942;Dbxref=EnsemblGenomes-Gn:Rv2942,EnsemblGenomes-Tr:CCP45745,GOA:P9WJU7,InterPro:IPR004869,NCBI_GP:CCP45745.1;Name=CCP45745.1;Note=Rv2942%2C (MTCY24G1.07c)%2C len: 920 aa. MmpL7%2Cconserved transmembrane transport protein (see citations below)%2C member of RND superfamily%2C highly similar to Q9XB10 hypothetical 99.5 KDA protein from Mycobacterium bovis BCG (945 aa)%2C FASTA scores: opt: 488%2C E(): 4.9e-20%2C (29.5%25 identity in 918 aa overlap)%3B and to others from Mycobacteria e.g. O53735|MML4_MYCTU from Mycobacterium tuberculosis (945 aa)%2C FASTA scores: opt: 481%2C E(): 1.2e-19%2C (25.9%25 identity in 922 aa overlap)%3B etc. Also similar to other membrane proteins e.g. O54101|MMLB_STRCO|SC10A5.10c putative membrane protein from Streptomyces coelicolor (847 aa)%2C FASTA scores: opt: 256%2CE(): 7.2e-07%2C (25.15%25 identity in 545 aa overlap)%3B etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site%2C PS00079 Multicopper oxidases signature 1%2C and PS00044 Bacterial regulatory proteins%2ClysR family signature. Belongs to the MmpL family. Note that Rv2941|fadD28 and Rv2942|mmpL7 are transcriptionally coupled (proven experimentally).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL7;inference=protein motif:PROSITE:PS00639;locus_tag=Rv2942;product=Conserved transmembrane transport protein MmpL7;protein_id=CCP45745.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3288463	3290504	.	+	.	ID=id-AL123456.3:3288463..3290504;Note=IS1533%2C len: 2042 nt. Minimum region corresponding to Insertion sequence IS1533.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1533
AL123456.3	EMBL	gene	3288464	3289705	.	+	.	ID=gene-Rv2943;Name=Rv2943;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2943
AL123456.3	EMBL	CDS	3288464	3289705	.	+	0	ID=cds-CCP45746.1;Parent=gene-Rv2943;Dbxref=EnsemblGenomes-Gn:Rv2943,EnsemblGenomes-Tr:CCP45746,GOA:I6X5T4,InterPro:IPR001584,InterPro:IPR011991,InterPro:IPR012337,InterPro:IPR013249,UniProtKB/TrEMBL:I6X5T4,NCBI_GP:CCP45746.1;Name=CCP45746.1;Note=Rv2943%2C (MTCY24G1.06c)%2C len: 413 aa. Probable transposase for insertion sequence IS1533%2C similar to other transposases e.g. P15025|ISTA_ECOLI ista protein (insertion sequence IS21) from Escherichia coli (390 aa)%2C FASTA scores: opt: 268%2C E(): 5.1e-11%2C (24.1%25 identity in 378 aa overlap). Contains potential helix-turn-helix motif at aa 19-40 (Score 1611%2C +4.67 SD).;gbkey=CDS;locus_tag=Rv2943;product=Probable transposase for insertion sequence element IS1533;protein_id=CCP45746.1;transl_table=11
AL123456.3	EMBL	gene	3289705	3290235	.	+	.	ID=gene-Rv2943A;Name=Rv2943A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2943A
AL123456.3	EMBL	CDS	3289705	3290235	.	+	0	ID=cds-CCP45747.1;Parent=gene-Rv2943A;Dbxref=EnsemblGenomes-Gn:Rv2943A,EnsemblGenomes-Tr:CCP45747,GOA:Q6MX22,InterPro:IPR002611,UniProtKB/TrEMBL:Q6MX22,NCBI_GP:CCP45747.1;Name=CCP45747.1;Note=Rv2943A%2C len: 176 aa. Possible transposase%2C similar to many e.g. AJ238712|MBO238712_2 putative transposase (IS21-l) from Mycobacterium bovis BCG (266 aa)%2C FASTA scores: opt: 762%2C E(): 0%2C (100.0%25 identity in 118 aa overlap). Possible frameshift after codon 118 i.e. near position 3290056%2C to fuse with Rv2944.;gbkey=CDS;locus_tag=Rv2943A;product=Possible transposase;protein_id=CCP45747.1;transl_table=11
AL123456.3	EMBL	gene	3289790	3290506	.	+	.	ID=gene-Rv2944;Name=Rv2944;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2944
AL123456.3	EMBL	CDS	3289790	3290506	.	+	0	ID=cds-CCP45748.1;Parent=gene-Rv2944;Dbxref=EnsemblGenomes-Gn:Rv2944,EnsemblGenomes-Tr:CCP45748,GOA:P96287,InterPro:IPR002611,InterPro:IPR003593,InterPro:IPR027417,InterPro:IPR028350,UniProtKB/TrEMBL:P96287,NCBI_GP:CCP45748.1;Name=CCP45748.1;Note=Rv2944%2C (MTCY24G1.05c)%2C len: 238 aa. Possible transposase for IS1533%2C similar to is-element proteins e.g. P15026|ISTB_ECOLI istb protein from Escherichia coli (265 aa)%2C FASTA scores: opt: 475%2C E (): 1.6e-21%2C (48.0%25 identity in 148 aa overlap)%3B Z95436|MTY15C10_14 from Mycobacterium tuberculosis (248 aa)%2C FASTA scores: opt: 784%2C E(): 0%2C(87.4%25 identity in 135 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2944;product=Possible transposase for insertion sequence element IS1533;protein_id=CCP45748.1;transl_table=11
AL123456.3	EMBL	gene	3290624	3291325	.	-	.	ID=gene-Rv2945c;Name=lppX;gbkey=Gene;gene=lppX;gene_biotype=protein_coding;locus_tag=Rv2945c
AL123456.3	EMBL	CDS	3290624	3291325	.	-	0	ID=cds-CCP45749.1;Parent=gene-Rv2945c;Dbxref=EnsemblGenomes-Gn:Rv2945c,EnsemblGenomes-Tr:CCP45749,GOA:P9WK65,InterPro:IPR009830,InterPro:IPR029046,PDB:2BYO,NCBI_GP:CCP45749.1;Name=CCP45749.1;Note=Rv2945c%2C (MTCY24G1.04)%2C len: 233 aa. Probable lppX%2Cconserved lipoprotein%2C equivalent to Q9CD80 putative lipoprotein from Mycobacterium leprae (233 aa)%2C FASTA scores: opt: 1165%2C E(): 2.1e-65%2C (76.4%25 identity in 233 aa overlap)%3B and similar to Q9CCP6|ML0557 from Mycobacterium leprae (238 aa)%2C FASTA scores: opt: 338%2C E(): 7.4e-14%2C(30.75%25 identity in 231 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. P71679|LPRG_MYCTU lipoprotein (236 aa)%2C FASTA scores: opt: 342%2C E(): 4.1e-14%2C(32.05%25 identity in 231 aa overlap)%3B etc. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C and has in its N-terminal a signal peptide. Belongs to the LPPX/lprafg family of lipoproteins. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppX;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2945c;product=Probable conserved lipoprotein LppX;protein_id=CCP45749.1;transl_table=11
AL123456.3	EMBL	gene	3291503	3296353	.	-	.	ID=gene-Rv2946c;Name=pks1;gbkey=Gene;gene=pks1;gene_biotype=protein_coding;locus_tag=Rv2946c
AL123456.3	EMBL	CDS	3291503	3296353	.	-	0	ID=cds-CCP45750.1;Parent=gene-Rv2946c;Dbxref=EnsemblGenomes-Gn:Rv2946c,EnsemblGenomes-Tr:CCP45750,GOA:P96285,InterPro:IPR001227,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR013968,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016040,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR020807,InterPro:IPR020842,InterPro:IPR020843,NCBI_GP:CCP45750.1;Name=CCP45750.1;Note=Rv2946c%2C (MTCY24G1.03)%2C len: 1616 aa. Probable pks1%2Cpolyketide synthase%2C similar to many e.g. ML035|AL583917|Q9CD81 putative polyketide synthase from Mycobacterium leprae (2103 aa)%2C Fasta scores: opt: 8761%2CE(): 0%2C (82.6%25 identity in 1620 aa overlap)%3B etc. Almost identical in part to G560507|Q50470 PKS002C protein from Mycobacterium tuberculosis (fragment) (950 aa)%2C Fasta scores: opt: 5685%2C E(): 0%2C (95.3%25 identity in 927 aa overlap). Also similar to Mycobacterium tuberculosis polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6%25 identity in 1632 aa)%3B pks12|Rv2048c|O53490 (4151 aa) (58.0%25 identity in 1606 aa)%3B pks8|rv1662|O65933 (1602 aa) (59.7%25 identity in 1144 aa). Contains a PS00012 Phosphopantetheine attachment site. Note pks1 has been shown to be involved in the biosynthesis of phthiocerol. pks15/pks1 has been shown to be involved in the biosynthesis of phenolphthiocerol glycolipids.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks1;inference=protein motif:PROSITE:PS00012;locus_tag=Rv2946c;product=Probable polyketide synthase Pks1;protein_id=CCP45750.1;transl_table=11
AL123456.3	EMBL	gene	3296350	3297840	.	-	.	ID=gene-Rv2947c;Name=pks15;gbkey=Gene;gene=pks15;gene_biotype=protein_coding;locus_tag=Rv2947c
AL123456.3	EMBL	CDS	3296350	3297840	.	-	0	ID=cds-CCP45751.1;Parent=gene-Rv2947c;Dbxref=EnsemblGenomes-Gn:Rv2947c,EnsemblGenomes-Tr:CCP45751,GOA:P96284,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR015083,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR018201,InterPro:IPR020841,NCBI_GP:CCP45751.1;Name=CCP45751.1;Note=Rv2947c%2C (MTCY24G1.02)%2C len: 496 aa. Probable pks15%2Cpolyketide synthase. Almost identical to G560508|Q50469 PKS002B protein from Mycobacterium tuberculosis (495 aa)%2CFASTA scores: opt: 3270%2C E(): 0%2C (99.6%25 identity in 496 a a overlap). Similar to Mycobacterium tuberculosis proteins MTCY338.20|RV2931|PPSA_MYCTU ppsA phenolpthiocerol synthesis (1876 aa) (49.9%25 identity in 465 aa overlap)%3B MTCY24G1.09|RV2940C|P96291 Putative mas%2C mycocerosic acid synthase (2111 aa) (50.2%25 identity in 454 aa overlap)%3B and MTCY22H8.03|RV2382C|P71718 hypothetical protein (444 aa) (47.6%25 identity in 437 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site. Note pks15 has been shown to be involved in the biosynthesis of phthiocerol. pks15/pks1 has been shown to be involved in the biosynthesis of phenolphthiocerol glycolipids.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks15;inference=protein motif:PROSITE:PS00606;locus_tag=Rv2947c;product=Probable polyketide synthase Pks15;protein_id=CCP45751.1;transl_table=11
AL123456.3	EMBL	gene	3297837	3299954	.	-	.	ID=gene-Rv2948c;Name=fadD22;gbkey=Gene;gene=fadD22;gene_biotype=protein_coding;locus_tag=Rv2948c
AL123456.3	EMBL	CDS	3297837	3299954	.	-	0	ID=cds-CCP45752.1;Parent=gene-Rv2948c;Dbxref=EnsemblGenomes-Gn:Rv2948c,EnsemblGenomes-Tr:CCP45752,GOA:P9WQ61,InterPro:IPR000873,InterPro:IPR009081,InterPro:IPR020806,InterPro:IPR025110,NCBI_GP:CCP45752.1;Name=CCP45752.1;Note=Rv2948c%2C (MTCY24G1.01)%2C len: 705 aa. FadD22%2Cp-hydroxybenzoyl-AMP ligase. Highly similar to many e.g. Q9CD82|ML0134 putative acyl-CoA synthetase from Mycobacterium leprae (707 aa)%2C fasta scores: opt: 3554%2CE(): 6.4e-209%2C (75.9%25 identity in 705 aa overlap). Almost identical to G560509|Q50468 PKS002A protein from Mycobacterium tuberculosis (705 aa)%2C fasta scores: opt: 4647%2C E(): 0%2C (99.7%25 identity in 705 aa overlap).;gbkey=CDS;gene=fadD22;locus_tag=Rv2948c;product=P-hydroxybenzoyl-AMP ligase FadD22;protein_id=CCP45752.1;transl_table=11
AL123456.3	EMBL	gene	3299971	3300570	.	-	.	ID=gene-Rv2949c;Name=Rv2949c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2949c
AL123456.3	EMBL	CDS	3299971	3300570	.	-	0	ID=cds-CCP45753.1;Parent=gene-Rv2949c;Dbxref=EnsemblGenomes-Gn:Rv2949c,EnsemblGenomes-Tr:CCP45753,GOA:P9WIC5,InterPro:IPR002800,InterPro:IPR028978,NCBI_GP:CCP45753.1;Name=CCP45753.1;Note=Rv2949c%2C (MTCY349.41)%2C len: 199 aa. Chorismate pyruvate lyase%2C equivalent to Q9CD83|ML0133 hypothetical protein from Mycobacterium leprae (210 aa)%2C FASTA scores: opt: 797%2C E(): 7.4e-47%2C (62.55%25 identity in 195 aa overlap). Equivalent to AAK47348 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 13 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2949c;product=Chorismate pyruvate lyase;protein_id=CCP45753.1;transl_table=11
AL123456.3	EMBL	gene	3300596	3302455	.	-	.	ID=gene-Rv2950c;Name=fadD29;gbkey=Gene;gene=fadD29;gene_biotype=protein_coding;locus_tag=Rv2950c
AL123456.3	EMBL	CDS	3300596	3302455	.	-	0	ID=cds-CCP45754.1;Parent=gene-Rv2950c;Dbxref=EnsemblGenomes-Gn:Rv2950c,EnsemblGenomes-Tr:CCP45754,GOA:P95141,InterPro:IPR000873,NCBI_GP:CCP45754.1;Name=CCP45754.1;Note=Rv2950c%2C (MTCY349.40)%2C len: 619 aa. fadD29%2Cfatty-acid-AMP synthetase%2C similar to various mycobacterial enzymes believed to be involved in polyketide or fatty acid synthesis. Equivalent (but shorter 61 aa) to Q9CD84 from Mycobacterium leprae (680 aa)%2C FASTA scores: opt: 3280%2CE(): 2.2e-192%2C (80.15%25 identity in 620 aa overlap)%3B and highly similar to others from Mycobacterium leprae e.g. Q9Z5K5 probable acyl-CoA synthase (583 aa)%2C FASTA scores: opt: 2358%2C E(): 3.4e-136%2C (62.35%25 identity in 579 aa overlap). Also similar to others from Mycobacterium tuberculosis e.g. Q10976|FD26_MYCTU putative fatty-acid--CoA ligase (583 aa)%2C FASTA scores: opt: 2416%2CE(): 1e-139%2C (63.15%25 identity in 581 aa overlap) (N-terminus shorter)%3B etc. Equivalent to AAK47349 from Mycobacterium tuberculosis strain CDC1551 (582 aa) but longer 37 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD29;locus_tag=Rv2950c;product=Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP45754.1;transl_table=11
AL123456.3	EMBL	gene	3303103	3304248	.	-	.	ID=gene-Rv2951c;Name=Rv2951c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2951c
AL123456.3	EMBL	CDS	3303103	3304248	.	-	0	ID=cds-CCP45755.1;Parent=gene-Rv2951c;Dbxref=EnsemblGenomes-Gn:Rv2951c,EnsemblGenomes-Tr:CCP45755,GOA:P9WIB7,InterPro:IPR011251,NCBI_GP:CCP45755.1;Name=CCP45755.1;Note=Rv2951c%2C (MTCY349.39)%2C len: 381 aa. Possible oxidoreductase%2C equivalent to Q9CD85 putative oxidoreductase from Mycobacterium leprae (382 aa)%2C FASTA scores: opt: 2225%2C E(): 7.6e-134%2C (84.8%25 identity in 382 aa overlap)%3B and similar to O30260 conserved hypothetical protein from Mycobacterium leprae (363 aa)%2C FASTA scores: opt: 652%2C E(): 6.1e-34%2C (32.55%25 identity in 344 aa overlap). Also similar to various oxidoreductases e.g. O29071|AF1196 N5%2CN10-methylenetetrahydromethanopterin reductase from Archaeoglobus fulgidus (348 aa)%2C FASTA scores: opt: 381%2C E(): 9.7e-17%2C (27.7%25 identity in 354 aa overlap)%3B Q58929|mer|MJ1534 F420-dependent methylenetetrahydromethanopterin reductase from Methanococcus jannaschii (331 aa)%2C FASTA scores: opt: 372%2CE(): 3.5e-16%2C (30.85%25 identity in 295 aa overlap)%3B Q9UXP0 putative F420-dependent N5%2CN10-methylene-tetrahydromethanopterin reductase from Methanolobus tindarius (326 aa)%2C FASTA scores: opt: 343%2CE(): 2.4e-14%2C (27.4%25 identity in 314 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2951c;product=Possible oxidoreductase;protein_id=CCP45755.1;transl_table=11
AL123456.3	EMBL	gene	3304441	3305253	.	+	.	ID=gene-Rv2952;Name=Rv2952;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2952
AL123456.3	EMBL	CDS	3304441	3305253	.	+	0	ID=cds-CCP45756.1;Parent=gene-Rv2952;Dbxref=EnsemblGenomes-Gn:Rv2952,EnsemblGenomes-Tr:CCP45756,GOA:P9WIN3,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP45756.1;Name=CCP45756.1;Note=Rv2952%2C (MTCY349.38)%2C len: 270 aa. Probable methyltransferase%2C equivalent to Q9CD86|ML0130 hypothetical protein from Mycobacterium leprae (270 aa)%2C FASTA scores: opt: 1584%2C E(): 6.1e-99%2C (83.7%25 identity in 270 aa overlap). Also highly similar to Q9RMN9|MTF2 putative methyltransferase from Mycobacterium smegmatis (274 aa)%2CFASTA scores: opt: 902%2C E(): 3.8e-53%2C (56.35%25 identity in 252 aa overlap). Also similar to other methyltransferases e.g. Q9ADL4|SORM O-methyltransferase from Polyangium cellulosum (346 aa)%2C FASTA scores: opt: 390%2C E(): 1.1e-18%2C(36.25%25 identity in 251 aa overlap)%3B Q54303|RAPM methyltransferase from Streptomyces hygroscopicus (317 aa)%2CFASTA scores: opt: 315%2C E(): 1.1e-13%2C (40.75%25 identity in 135 aa overlap)%3B etc. Very similar to C-terminal part of Q50584|Rv1523|MTCY19G5.05c hypothetical 37.9 KDA protein from Mycobacterium tuberculosis (358 aa)%2C FASTA score: opt: 965%2C E(): 2.7e-57%2C (60.3%25 identity in 247 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2952;product=Possible methyltransferase (methylase);protein_id=CCP45756.1;transl_table=11
AL123456.3	EMBL	gene	3305279	3306535	.	+	.	ID=gene-Rv2953;Name=Rv2953;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2953
AL123456.3	EMBL	CDS	3305279	3306535	.	+	0	ID=cds-CCP45757.1;Parent=gene-Rv2953;Dbxref=EnsemblGenomes-Gn:Rv2953,EnsemblGenomes-Tr:CCP45757,GOA:P9WGV5,InterPro:IPR005097,InterPro:IPR016040,NCBI_GP:CCP45757.1;Name=CCP45757.1;Note=Rv2953%2C (MTCY349.37c)%2C len: 418 aa. Enoyl reductase%2Cequivalent to Q9CD87|ML0129 hypothetical protein from Mycobacterium leprae (418 aa)%2C FASTA scores: opt: 2357%2CE(): 2.7e-143%2C (86.6%25 identity in 418 aa overlap). Also highly similar to Q9X7N5|SC5F2A.12c conserved hypothetical protein from Streptomyces coelicolor (396 aa)%2C FASTA scores: opt: 491%2C E(): 7e-24%2C (38.35%25 identity in 417 aa overlap)%3B and similar to other hypothetical proteins e.g. Q9VG81 CG5167 protein from Drosophila melanogaster (Fruit fly) (431 aa)%2C FASTA scores: opt: 393%2C E(): 1.4e-17%2C(26.55%25 identity in 433 aa overlap)%3B Q9GZE9|F22F7.1 hypothetical protein from Caenorhabditis elegans (426 aa)%2CFASTA scores: opt: 338%2C E(): 4.6e-14%2C (27.05%25 identity in 425 aa overlap)%3B P73855|SLL1601 hypothetical 44.8 KDA protein from Synechocystis sp. (strain PCC 6803) (414 aa)%2CFASTA scores: opt: 565%2C E(): 1.3e-28%2C (35.7%25 identity in 409 aa overlap)%3B etc. Also highly similar to other proteins from Mycobacterium tuberculosis e.g. RV2449C|O53176|MTV008.05C hypothetical 44.4 KDA protein (419 aa)%2C FASTA scores: opt: 1835%2C E(): 7e-110%2C (67.55%25 identity in 419 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2953;product=Enoyl reductase;protein_id=CCP45757.1;transl_table=11
AL123456.3	EMBL	gene	3306666	3307391	.	-	.	ID=gene-Rv2954c;Name=Rv2954c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2954c
AL123456.3	EMBL	CDS	3306666	3307391	.	-	0	ID=cds-CCP45758.1;Parent=gene-Rv2954c;Dbxref=EnsemblGenomes-Gn:Rv2954c,EnsemblGenomes-Tr:CCP45758,GOA:I6X5U4,InterPro:IPR029063,UniProtKB/TrEMBL:I6X5U4,NCBI_GP:CCP45758.1;Name=CCP45758.1;Note=Rv2954c%2C (MTCY349.36)%2C len: 241 aa. Hypothetical unknown protein. Equivalent to AAK47354 from Mycobacterium tuberculosis strain CDC1551 (199 aa) but longer 42 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2954c;product=Hypothetical protein;protein_id=CCP45758.1;transl_table=11
AL123456.3	EMBL	gene	3307580	3308545	.	-	.	ID=gene-Rv2955c;Name=Rv2955c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2955c
AL123456.3	EMBL	CDS	3307580	3308545	.	-	0	ID=cds-CCP45759.1;Parent=gene-Rv2955c;Dbxref=EnsemblGenomes-Gn:Rv2955c,EnsemblGenomes-Tr:CCP45759,GOA:P95137,InterPro:IPR006342,InterPro:IPR029063,UniProtKB/TrEMBL:P95137,NCBI_GP:CCP45759.1;Name=CCP45759.1;Note=Rv2955c%2C (MTCY349.34)%2C len: 321 aa. Conserved protein%2C similar to others e.g. Q98NV5|MLL9724 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (284 aa)%2CFASTA scores: opt: 231%2C E(): 6.5e-08%2C (34.6%25 identity in 182 aa overlap)%3B Q9AGG2|NLPE1 NLPE1 from Rhizobium etli (249 aa)%2C FASTA scores: opt: 212%2C E(): 1.1e-06%2C (27.85%25 identity in 255 aa overlap)%3B Q9KXY2 hypothetical 31.3 KDA protein from Streptomyces coelicolor(291 aa)%2C FASTA scores: opt: 211%2C E(): 1.4e-06%2C (30.9%25 identity in 249 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2955c;product=Conserved protein;protein_id=CCP45759.1;transl_table=11
AL123456.3	EMBL	gene	3308668	3309399	.	+	.	ID=gene-Rv2956;Name=Rv2956;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2956
AL123456.3	EMBL	CDS	3308668	3309399	.	+	0	ID=cds-CCP45760.1;Parent=gene-Rv2956;Dbxref=EnsemblGenomes-Gn:Rv2956,EnsemblGenomes-Tr:CCP45760,GOA:I6Y242,InterPro:IPR006342,InterPro:IPR029063,UniProtKB/TrEMBL:I6Y242,NCBI_GP:CCP45760.1;Name=CCP45760.1;Note=Rv2956%2C (MTCY349.33c)%2C len: 243 aa. Conserved protein%2C highly similar to O86299|GSC GSC protein from Mycobacterium avium subsp. silvaticum Mycobacterium avium (240 aa)%2C FASTA scores: opt: 1070%2C E(): 3.5e-63%2C (67.5%25 identity in 240 aa overlap)%3B and O86294|GSC GSC protein from Mycobacterium paratuberculosis (240 aa)%2C FASTA scores: opt: 1070%2C E(): 3.5e-63%2C (67.5%25 identity in 240 aa overlap). Also some similarity with other proteins from other organisms e.g. Q9L727 nodulation protein NOEI from Rhizobium fredii (Sinorhizobium fredii) (241 aa)%2C FASTA scores: opt: 205%2C E(): 3.5e-06%2C (27.25%25 identity in 198 aa overlap)%3B Q9AGG1|LPEA LPEA protein from Rhizobium etli (286 aa)%2C FASTA scores: opt: 201%2C E(): 7.2e-06%2C (28.85%25 identity in 208 aa overlap)%3B P74191|SLL1173 hypothetical 28.0 KDA protein Synechocystis sp. (strain PCC 6803) (244 aa)%2C FASTA scores: opt: 274%2C E(): 1e-10%2C (30.65%25 identity in 225 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P71792|RV1513|MTCY277.35 hypothetical 26.7 KDA protein (243 aa)%2C FASTA scores: opt: 1105%2C E(): 1.7e-65%2C (70.05%25 identity in 237 aa overlap)%3B etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2956;product=Conserved protein;protein_id=CCP45760.1;transl_table=11
AL123456.3	EMBL	gene	3309470	3310297	.	+	.	ID=gene-Rv2957;Name=Rv2957;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2957
AL123456.3	EMBL	CDS	3309470	3310297	.	+	0	ID=cds-CCP45761.1;Parent=gene-Rv2957;Dbxref=EnsemblGenomes-Gn:Rv2957,EnsemblGenomes-Tr:CCP45761,GOA:P9WMX7,InterPro:IPR001173,InterPro:IPR029044,NCBI_GP:CCP45761.1;Name=CCP45761.1;Note=Rv2957%2C (MTCY349.31c)%2C len: 275 aa. Possible glycosyl transferase %3B possibly secreted protein. Highly similar to O88109|GSD|GTFD GSD protein from Mycobacterium avium subsp. silvaticum%2C Mycobacterium paratuberculosis%2Cand Mycobacterium avium (266 aa)%2C FASTA scores: opt: 1010%2CE(): 2.5e-62%2C (68.8%25 identity in 221 aa overlap). Also some similarity with other proteins and especially glycosyl transferases e.g. Q9AEE4 hypothetical 31.4 KDA protein from Leptospira interrogans (265 aa)%2C FASTA scores: opt: 371%2CE(): 3.3e-18%2C (34.43%25 identity in 212 aa overlap)%3B Q9EXY4 putative glycosyl transferase from Escherichia coli (248 aa)%2C FASTA scores: opt: 339%2C E(): 5e-16%2C (32.4%25 identity in 210 aa overlap)%3B Q9RCC4 glycosyltransferase-like protein from Yersinia pestis (247 aa)%2C FASTA scores: opt: 333%2C E(): 1.3e-15%2C (31.8%25 identity in 217 aa overlap)%3B Q9EXY1 putative glycosyl transferase from Escherichia coli (248 aa)%2C FASTA scores: opt: 328%2C E(): 2.9e-15%2C (31.9%25 identity in 210 aa overlap)%3B etc. Equivalent to AAK47357 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 19 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2957;product=Possible glycosyl transferase;protein_id=CCP45761.1;transl_table=11
AL123456.3	EMBL	gene	3310714	3312000	.	-	.	ID=gene-Rv2958c;Name=Rv2958c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2958c
AL123456.3	EMBL	CDS	3310714	3312000	.	-	0	ID=cds-CCP45762.1;Parent=gene-Rv2958c;Dbxref=EnsemblGenomes-Gn:Rv2958c,EnsemblGenomes-Tr:CCP45762,GOA:P9WFR1,InterPro:IPR002213,NCBI_GP:CCP45762.1;Name=CCP45762.1;Note=Rv2958c%2C (MTCY349.30)%2C len: 428 aa. Possible glycosyl transferase (see citation below)%2C highly similar to Q9CD88|ML0128 putative glycosyl transferase from Mycobacterium leprae (435 aa)%2C FASTA scores: opt: 2116%2CE(): 5.8e-126%2C (75.05%25 identity in 417 aa overlap)%3B and Q9CD91|ML0125 putative glycosyl transferase from Mycobacterium leprae (438 aa)%2C FASTA scores: opt: 2104%2CE(): 3.3e-125%2C (74.65%25 identity in 418 aa overlap). Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3 putative glycosyltransferase from Deinococcus radiodurans (418 aa)%2C FASTA scores: opt: 317%2C E(): 1.9e-12%2C(31.0%25 identity in 297 aa overlap)%3B Q9S1V2 putative glycosyl transferase from Streptomyces coelicolor (407 aa)%2CFASTA scores: opt: 264%2C E(): 4.1e-09%2C (27.2%25 identity in 342 aa overlap)%3B P72650|CRTX|SLR1125 zeaxanthin glucosyl transferase from Synechocystis sp. strain PCC 6803 (419 aa)%2C FASTA scores: opt: 251%2C E(): 2.8e-08%2C (26.8%25 identity in 295 aa overlap)%3B etc. Very similar to P95130|MTCY349.25 from Mycobacterium tuberculosis (449 aa)%2C FASTA score: opt: 2215%2C E(): 3.3e-132%2C (77.25%25 identity in 422 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2958c;product=Possible glycosyl transferase;protein_id=CCP45762.1;transl_table=11
AL123456.3	EMBL	gene	3312101	3312838	.	-	.	ID=gene-Rv2959c;Name=Rv2959c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2959c
AL123456.3	EMBL	CDS	3312101	3312838	.	-	0	ID=cds-CCP45763.1;Parent=gene-Rv2959c;Dbxref=EnsemblGenomes-Gn:Rv2959c,EnsemblGenomes-Tr:CCP45763,GOA:P9WIM5,InterPro:IPR007072,InterPro:IPR029063,NCBI_GP:CCP45763.1;Name=CCP45763.1;Note=Rv2959c%2C (MTCY349.29)%2C len: 245 aa. Possible methyltransferase%2C highly similar to Q9CD89|ML0127 from Mycobacterium leprae (229 aa)%2C FASTA scores: opt: 1183%2CE(): 3.9e-69%2C (76.1%25 identity in 226 aa overlap). Also some similarity with other methyltransferases and other proteins e.g. Q51079 putative methyl transferase from Nocardia lactamdurans (236 aa)%2C FASTA scores: opt: 156%2C E(): 0.0086%2C(23.25%25 identity in 159 aa overlap)%3B Q98ID5 cephalosporin hydroxylase from Rhizobium loti (Mesorhizobium loti) (217 aa)%2C FASTA scores: opt: 275%2C E(): 1.7e-10%2C (29.65%25 identity in 199 aa overlap)%3B etc. And also similar to P72897 hypothetical 27.8 KDA protein from Mycobacterium tuberculosis (249 aa)%2C FASTA scores: opt: 292%2C E(): 1.5e-11%2C (31.25%25 identity in 208 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2959c;product=Possible methyltransferase (methylase);protein_id=CCP45763.1;transl_table=11
AL123456.3	EMBL	gene	3312953	3313201	.	-	.	ID=gene-Rv2960c;Name=Rv2960c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2960c
AL123456.3	EMBL	CDS	3312953	3313201	.	-	0	ID=cds-CCP45764.1;Parent=gene-Rv2960c;Dbxref=EnsemblGenomes-Gn:Rv2960c,EnsemblGenomes-Tr:CCP45764,UniProtKB/TrEMBL:P95133,NCBI_GP:CCP45764.1;Name=CCP45764.1;Note=Rv2960c%2C (MT3036%2C MTCY349.28)%2C len: 82 aa. Hypothetical unknown protein%2C equivalent to AAK47362 from Mycobacterium tuberculosis strain CDC1551 (116 aa) but shorter 34 aa. Shortened version of MTCY349.28 avoiding overlap. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv2960c;product=Hypothetical protein;protein_id=CCP45764.1;transl_table=11
AL123456.3	EMBL	gene	3313283	3313672	.	+	.	ID=gene-Rv2961;Name=Rv2961;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2961
AL123456.3	EMBL	CDS	3313283	3313672	.	+	0	ID=cds-CCP45765.1;Parent=gene-Rv2961;Dbxref=EnsemblGenomes-Gn:Rv2961,EnsemblGenomes-Tr:CCP45765,GOA:P95131,InterPro:IPR002559,UniProtKB/TrEMBL:P95131,NCBI_GP:CCP45765.1;Name=CCP45765.1;Note=Rv2961%2C (MTCY349.26c)%2C len: 129 aa. Probable transposase%2C highly similar to C-terminus of O50414|Rv3387|MTV004.45 putative transposase from Mycobacterium tuberculosis (225 aa)%2C FASTA scores: opt: 605%2C E(): 7.2e-34%2C (66.65%25 identity in 129 aa overlap)%3B and similar to others e.g. CAC47401 putative partial transposase for ISRM17 protein from Rhizobium meliloti (Sinorhizobium meliloti) (174 aa)%2C FASTA scores: opt: 183%2CE(): 2.6e-05%2C (30.25%25 identity in 129 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2961;product=Probable transposase;protein_id=CCP45765.1;transl_table=11
AL123456.3	EMBL	gene	3313773	3315122	.	-	.	ID=gene-Rv2962c;Name=Rv2962c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2962c
AL123456.3	EMBL	CDS	3313773	3315122	.	-	0	ID=cds-CCP45766.1;Parent=gene-Rv2962c;Dbxref=EnsemblGenomes-Gn:Rv2962c,EnsemblGenomes-Tr:CCP45766,GOA:P9WN09,InterPro:IPR002213,NCBI_GP:CCP45766.1;Name=CCP45766.1;Note=Rv2962c%2C (MTCY349.25)%2C len: 449 aa. Possible glycosyl transferase (see citation below)%2C highly similar or identical to Mycobacterium tuberculosis proteins G560522 U0002JA%2C G560521 U0002H%2C G560522 U0002JA%2C G560519 U0002KA. Equivalent (but longer 21 aa) to Q9CD91 putative glycosyl transferase from Mycobacterium leprae (438 aa)%2C FASTA scores: opt: 2229%2C E(): 1.3e-133%2C (77.45%25 identity in 426 aa overlap)%3B and highly similar to Q9CD88 putative glycosyl transferase from Mycobacterium leprae (435 aa)%2C FASTA scores: opt: 2129%2C E(): 2.7e-127%2C (74.35%25 identity in 425 aa overlap)%3B and others from Mycobacterium leprae. Also shows some similarity to variety of glycosyl transferases e.g. Q9RYI3|DRA0329 putative glycosyl transferase from Deinococcus radiodurans (418 aa)%2C FASTA scores: opt: 340%2CE(): 5.5e-14%2C (31.2%25 identity in 330 aa overlap)%3B P72650 zeaxanthin glucosyl transferase from Synechocystis sp. (strain PCC 6803) (419 aa)%2C FASTA scores: opt: 244%2C E(): 6.6e-08%2C (26.2%25 identity in 294 aa overlap)%3B etc. Also highly similar to P95134 hypothetical 46.8 KDA protein from Mycobacterium tuberculosis (428 aa)%2C FASTA scores: opt: 2215%2C E(): 9.6e-133%2C (77.25%25 identity in 422 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2962c;product=Possible glycosyl transferase;protein_id=CCP45766.1;transl_table=11
AL123456.3	EMBL	gene	3315236	3316456	.	+	.	ID=gene-Rv2963;Name=Rv2963;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2963
AL123456.3	EMBL	CDS	3315236	3316456	.	+	0	ID=cds-CCP45767.1;Parent=gene-Rv2963;Dbxref=EnsemblGenomes-Gn:Rv2963,EnsemblGenomes-Tr:CCP45767,InterPro:IPR005524,UniProtKB/TrEMBL:I6YET7,NCBI_GP:CCP45767.1;Name=CCP45767.1;Note=Rv2963%2C (MTCY349.24c)%2C len: 406 aa. Probable integral membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2963;product=Probable integral membrane protein;protein_id=CCP45767.1;transl_table=11
AL123456.3	EMBL	gene	3316529	3317461	.	+	.	ID=gene-Rv2964;Name=purU;gbkey=Gene;gene=purU;gene_biotype=protein_coding;locus_tag=Rv2964
AL123456.3	EMBL	CDS	3316529	3317461	.	+	0	ID=cds-CCP45768.1;Parent=gene-Rv2964;Dbxref=EnsemblGenomes-Gn:Rv2964,EnsemblGenomes-Tr:CCP45768,GOA:P9WHM3,InterPro:IPR002376,InterPro:IPR002912,InterPro:IPR004810,NCBI_GP:CCP45768.1;Name=CCP45768.1;Note=Rv2964%2C (MTCY349.23c)%2C len: 310 aa. Probable purU%2Cformyltetrahydrofolate deformylase%2C highly similar to others e.g. Q9RWT1|DR0584 formyltetrahydrofolate deformylase from Deinococcus radiodurans (298 aa)%2C FASTA scores: opt: 1005%2C E(): 4.9e-52%2C (52.25%25 identity in 297 aa overlap)%3B Q9K7U4 formyltetrahydrofolate deformylase from Bacillus halodurans (289 aa)%2C FASTA scores: opt: 982%2C E(): 1.1e-50%2C (51.8%25 identity in 280 aa overlap)%3B Q55135|PURU_SYNY3|SLL0070 formyltetrahydrofolate deformylase from Synechocystis sp. strain PCC 6803 (284 aa)%2C FASTA scores: opt: 839%2C E(): 2.9e-42%2C (48.2%25 identity in 280 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purU;locus_tag=Rv2964;product=Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase);protein_id=CCP45768.1;transl_table=11
AL123456.3	EMBL	gene	3318330	3318815	.	-	.	ID=gene-Rv2965c;Name=kdtB;gbkey=Gene;gene=kdtB;gene_biotype=protein_coding;gene_synonym=coaD;locus_tag=Rv2965c
AL123456.3	EMBL	CDS	3318330	3318815	.	-	0	ID=cds-CCP45769.1;Parent=gene-Rv2965c;Dbxref=EnsemblGenomes-Gn:Rv2965c,EnsemblGenomes-Tr:CCP45769,GOA:P9WPA5,InterPro:IPR001980,InterPro:IPR004821,InterPro:IPR014729,PDB:1TFU,PDB:3LCJ,PDB:3NBA,PDB:3NBK,PDB:3PNB,PDB:3RBA,PDB:3RFF,PDB:3RHS,PDB:3UC5,PDB:4E1A,NCBI_GP:CCP45769.1;Name=CCP45769.1;Note=Rv2965c%2C (MTCY349.22)%2C len: 161 aa. Probable kdtB (alternate gene name: coaD)%2C phosphopantetheine adenylyltransferase%2C equivalent to O69466|COAD_MYCLE phosphopantetheine adenylyltransferase from Mycobacterium leprae (160 aa)%2C FASTA scores: opt: 881%2C E(): 2.5e-54%2C(84.1%25 identity in 157 aa overlap). Also highly similar to others e.g. Q9ZBR1|COAD_STRCO from Streptomyces coelicolor (159 aa)%2C FASTA scores: opt: 575%2C E(): 5.8e-33%2C (54.1%25 identity in 159 aa overlap)%3B Q9WZK0|COAD_THEMA from Thermotoga maritima (161 aa)%2C FASTA scores: opt: 509%2C E(): 2.4e-28%2C (50.0%25 identity in 154 aa overlap)%3B P23875|COAD_ECOLICOAD|KDTB|B3634|Z5058|ECS4509 from Escherichia coli strain O157:H7 and K12 (159 aa)%2C FASTA scores: opt: 459%2C E(): 7.3e-25%2C (45.15%25 identity in 155 aa overlap)%3B etc. Belongs to the CoaD family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kdtB;locus_tag=Rv2965c;product=Probable phosphopantetheine adenylyltransferase KdtB (pantetheine-phosphate adenylyltransferase) (PPAT) (dephospho-CoA pyrophosphorylase);protein_id=CCP45769.1;transl_table=11
AL123456.3	EMBL	repeat_region	3318835	3318889	.	-	.	ID=id-AL123456.3:3318835..3318889;Note=55 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	gene	3318901	3319467	.	-	.	ID=gene-Rv2966c;Name=Rv2966c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2966c
AL123456.3	EMBL	CDS	3318901	3319467	.	-	0	ID=cds-CCP45770.1;Parent=gene-Rv2966c;Dbxref=EnsemblGenomes-Gn:Rv2966c,EnsemblGenomes-Tr:CCP45770,GOA:I6XFS7,InterPro:IPR002052,InterPro:IPR004398,InterPro:IPR029063,UniProtKB/TrEMBL:I6XFS7,NCBI_GP:CCP45770.1;Name=CCP45770.1;Note=Rv2966c%2C (MTCY349.21)%2C len: 188 aa. Possible methyltransferase%2C equivalent (but shorter 36 aa) to O69465|MLCB1243.09 hypothetical 23.0 KDA protein from Mycobacterium leprae (220 aa)%2C FASTA scores: opt: 872%2C E(): 9.1e-50%2C (74.2%25 identity in 182 aa overlap). Also similar to others e.g. Q9ZBR2|SC7A1.11 putative methylase from Streptomyces coelicolor (195 aa)%2C FASTA scores: opt: 510%2CE(): 3.7e-26%2C (47.5%25 identity in 179 aa overlap)%3B Q9F842 hypothetical methyltransferase (fragment) from Mycobacterium smegmatis (80 aa)%2C FASTA scores: opt: 386%2CE(): 2.5e-18%2C (75.0%25 identity in 80 aa overlap)%3B P10120|YHHF_ECOLI|YHHFZ|B3465 putative methylase from Escherichia colistrain K12 (198 aa)%2C FASTA scores: opt: 319%2C E(): 1.1e-13%2C (35.5%25 identity in 183 aa overlap)%3B etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature.;gbkey=CDS;inference=protein motif:PROSITE:PS00092;locus_tag=Rv2966c;product=Possible methyltransferase (methylase);protein_id=CCP45770.1;transl_table=11
AL123456.3	EMBL	repeat_region	3319468	3319568	.	-	.	ID=id-AL123456.3:3319468..3319568;Note=101 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3319569	3319666	.	-	.	ID=id-AL123456.3:3319569..3319666;Note=98 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	gene	3319663	3323046	.	-	.	ID=gene-Rv2967c;Name=pca;gbkey=Gene;gene=pca;gene_biotype=protein_coding;locus_tag=Rv2967c
AL123456.3	EMBL	CDS	3319663	3323046	.	-	0	ID=cds-CCP45771.1;Parent=gene-Rv2967c;Dbxref=EnsemblGenomes-Gn:Rv2967c,EnsemblGenomes-Tr:CCP45771,GOA:I6YEU0,InterPro:IPR000089,InterPro:IPR000891,InterPro:IPR001882,InterPro:IPR003379,InterPro:IPR005479,InterPro:IPR005481,InterPro:IPR005482,InterPro:IPR005930,InterPro:IPR011053,InterPro:IPR011054,InterPro:IPR011761,InterPro:IPR011764,InterPro:IPR013785,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,UniProtKB/TrEMBL:I6YEU0,NCBI_GP:CCP45771.1;Name=CCP45771.1;Note=Rv2967c%2C (MTCY349.20)%2C len: 1127 aa. Probable pca%2Cpyruvate carboxylase (ala-rich protein)%2C equivalent to Q9F843|PYC pyruvate carboxylase from Mycobacterium smegmatis (1127 aa)%2C FASTA scores: opt: 6232%2C E(): 0%2C(83.3%25 identity in 1127 aa overlap). Also highly similar to others e.g. Q9RK64|SCF11.26c pyruvate carboxylase from Streptomyces coelicolor (1124 aa)%2C FASTA scores: opt: 5526%2CE(): 0%2C (74.65%25 identity in 1125 aa overlap)%3B O54587|PYC pyruvate carboxylase from Corynebacterium glutamicum (Brevibacterium flavum) (1140 aa)%2C FASTA scores: opt: 4811%2CE(): 0%2C (64.5%25 identity in 1132 aa overlap)%3B Q9DDT1 pyruvate carboxylase from Brachydanio rerio (Zebrafish) (1180 aa)%2C FASTA scores: opt: 3133%2C E(): 1.1e-171%2C (47.8%25 identity in 1142 aa overlap)%3B etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2%2C PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site%2C and PS00188 Biotin-requiring enzymes attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pca;inference=protein motif:PROSITE:PS00867;locus_tag=Rv2967c;product=Probable pyruvate carboxylase Pca (pyruvic carboxylase);protein_id=CCP45771.1;transl_table=11
AL123456.3	EMBL	gene	3323071	3323703	.	-	.	ID=gene-Rv2968c;Name=Rv2968c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2968c
AL123456.3	EMBL	CDS	3323071	3323703	.	-	0	ID=cds-CCP45772.1;Parent=gene-Rv2968c;Dbxref=EnsemblGenomes-Gn:Rv2968c,EnsemblGenomes-Tr:CCP45772,InterPro:IPR012932,UniProtKB/TrEMBL:I6X5W1,NCBI_GP:CCP45772.1;Name=CCP45772.1;Note=Rv2968c%2C (MTCY349.19)%2C len: 210 aa. Probable conserved integral membrane protein%2C equivalent to O69464 putative integral membrane protein from Mycobacterium leprae (214 aa)%2C FASTA scores: opt: 1060%2C E(): 1.4e-58%2C(71.95%25 identity in 214 aa overlap). Also highly similar to others e.g. Q9F844 hypothetical integral membrane protein from Mycobacterium smegmatis (187 aa)%2C FASTA scores: opt: 883%2C E(): 1.2e-47%2C (62.8%25 identity in 190 aa overlap)%3B Q9KXP3 putative integral membrane protein from Streptomyces coelicolor (240 aa)%2C FASTA scores: opt: 503%2C E(): 4.6e-24%2C(38.0%25 identity in 192 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2968c;product=Probable conserved integral membrane protein;protein_id=CCP45772.1;transl_table=11
AL123456.3	EMBL	gene	3323709	3324476	.	-	.	ID=gene-Rv2969c;Name=Rv2969c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2969c
AL123456.3	EMBL	CDS	3323709	3324476	.	-	0	ID=cds-CCP45773.1;Parent=gene-Rv2969c;Dbxref=EnsemblGenomes-Gn:Rv2969c,EnsemblGenomes-Tr:CCP45773,GOA:O33272,InterPro:IPR012336,PDB:4IHU,PDB:4JR4,PDB:4JR6,PDB:4K6X,UniProtKB/TrEMBL:O33272,NCBI_GP:CCP45773.1;Name=CCP45773.1;Note=Rv2969c%2C (MTCY349.18)%2C len: 255 aa. Possible conserved membrane or exported protein%2C equivalent to Q9CBS4|ML1667 possible conserved membrane protein from Mycobacterium leprae (264 aa)%2C FASTA scores: opt: 1101%2CE(): 9.9e-68%2C (65.9%25 identity in 258 aa overlap)%3B and highly similar to O69463 putative transmembrane protein from Mycobacterium leprae (258 aa)%2C FASTA scores: opt: 1097%2C E(): 1.8e-67%2C (65.5%25 identity in 258 aa overlap). C-terminus also highly similar to Q9KK65|996A160 exported protein (fragment) from Mycobacterium avium (85 aa)%2C FASTA scores: opt: 418%2C E(): 2e-21%2C (72.95%25 identity in 85 aa overlap). Also weakly similar to membrane or exported proteins e.g. Q9S2U7|SC4G6.04c putative integral membrane protein from Streptomyces coelicolor (275 aa)%2C FASTA scores: opt: 312%2C E(): 7.6e-14%2C (28.25%25 identity in 230 aa overlap)%3B Q9XAB6|SCC22.22C putative secreted protein from Streptomyces coelicolor (255 aa)%2C FASTA scores: opt: 181%2CE(): 6.4e-05%2C (27.0%25 identity in 226 aa overlap)%3B etc. Also some similarity with P72001|PKNE_MYCTU from Mycobacterium tuberculosis (566 aa)%2C FASTA scores: opt: 264%2C E(): 2.3e-10%2C (30.5%25 identity in 177 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2969c;product=Possible conserved membrane or secreted protein;protein_id=CCP45773.1;transl_table=11
AL123456.3	EMBL	gene	3324573	3325703	.	-	.	ID=gene-Rv2970c;Name=lipN;gbkey=Gene;gene=lipN;gene_biotype=protein_coding;locus_tag=Rv2970c
AL123456.3	EMBL	CDS	3324573	3325703	.	-	0	ID=cds-CCP45774.1;Parent=gene-Rv2970c;Dbxref=EnsemblGenomes-Gn:Rv2970c,EnsemblGenomes-Tr:CCP45774,GOA:P95125,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:P95125,NCBI_GP:CCP45774.1;Name=CCP45774.1;Note=Rv2970c%2C (MTCY349.17)%2C len: 376 aa. Probable lipN%2Clipase/esterase%2C similar to others e.g. Q9AA37|CC0771 putative esterase from Caulobacter crescentus (380 aa)%2CFASTA scores: opt: 822%2C E(): 8e-46%2C (42.15%25 identity in 318 aa overlap)%3B Q9XDR4 esterase HDE from petroleum-degrading bacterium HD-1 (317 aa)%2C FASTA scores: opt: 738%2C E(): 2e-40%2C (48.85%25 identity in 262 aa overlap)%3B O52270 lipase from Pseudomonas sp. (strain B11-1) (308 aa)%2C FASTA scores: opt: 683%2C E(): 7.3e-37%2C (41.3%25 identity in 288 aa overlap)%3B etc. Also similar to P71668 hypothetical 34.1 KDA protein from Mycobacterium tuberculosis (320 aa)%2C FASTA scores: opt: 715%2C E(): 6.3e-39%2C (42.3%25 identity in 298 aa overlap). Equivalent to AAK47374 from Mycobacterium tuberculosis strain CDC1551 (309 aa) but longer 67 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipN;locus_tag=Rv2970c;product=Probable lipase/esterase LipN;protein_id=CCP45774.1;transl_table=11
AL123456.3	EMBL	gene	3325934	3326104	.	+	.	ID=gene-Rv2970A;Name=Rv2970A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2970A
AL123456.3	EMBL	CDS	3325934	3326104	.	+	0	ID=cds-CCP45775.1;Parent=gene-Rv2970A;Dbxref=EnsemblGenomes-Gn:Rv2970A,EnsemblGenomes-Tr:CCP45775,GOA:I6XFT2,InterPro:IPR018170,InterPro:IPR023210,UniProtKB/TrEMBL:I6XFT2,NCBI_GP:CCP45775.1;Name=CCP45775.1;Note=Rv2970A%2C len: 56 aa. Conserved hypothetical protein%2Csimilar to C-terminal part of several oxidoreductases e.g. Rv2971|Z83018|MTCY349_22 from Mycobacterium tuberculosis (282 aa)%2C FASTA scores: opt: 158%2C E(): 3.6e-06%2C (45.0%25 identity in 60 aa overlap). May represent a gene fragment.;gbkey=CDS;locus_tag=Rv2970A;product=Conserved hypothetical protein;protein_id=CCP45775.1;transl_table=11
AL123456.3	EMBL	gene	3326101	3326949	.	+	.	ID=gene-Rv2971;Name=Rv2971;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2971
AL123456.3	EMBL	CDS	3326101	3326949	.	+	0	ID=cds-CCP45776.1;Parent=gene-Rv2971;Dbxref=EnsemblGenomes-Gn:Rv2971,EnsemblGenomes-Tr:CCP45776,GOA:P9WQA5,InterPro:IPR001395,InterPro:IPR018170,InterPro:IPR020471,InterPro:IPR023210,PDB:4OTK,NCBI_GP:CCP45776.1;Name=CCP45776.1;Note=Rv2971%2C (MTCY349.16c)%2C len: 282 aa. Probable oxidoreductase%2C possibly aldo/keto reductase%2C equivalent to O69462 putative oxidoreductase from Mycobacterium leprae (282 aa)%2C FASTA scores: opt: 1495%2C E(): 4.9e-93%2C (82.35%25 identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C oxidoreductase from Streptomyces coelicolor (276 aa)%2C FASTA scores: opt: 849%2C E(): 1.2e-49%2C(51.7%25 identity in 267 aa overlap)%3B Q9ZBW7|SC4B5.01C putative oxidoreductase from Streptomyces coelicolor (277 aa)%2C FASTA scores: opt: 847%2C E(): 1.7e-49%2C (49.1%25 identity in 271 aa overlap)%3B Q46857|YQHE_ECOLI|YQHE|B3012 hypothetical oxidoreductase from Escherichia coli strain K12 (275 aa)%2C FASTA scores: opt: 827%2C E(): 3.7e-48%2C (47.45%25 identity in 276 aa overlap)%3B etc. Contains PS00063 Aldo/keto reductase family putative active site signature%3B and PS00062 Aldo/keto reductase family signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00063;locus_tag=Rv2971;product=Probable oxidoreductase;protein_id=CCP45776.1;transl_table=11
AL123456.3	EMBL	gene	3327023	3327736	.	-	.	ID=gene-Rv2972c;Name=Rv2972c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2972c
AL123456.3	EMBL	CDS	3327023	3327736	.	-	0	ID=cds-CCP45777.1;Parent=gene-Rv2972c;Dbxref=EnsemblGenomes-Gn:Rv2972c,EnsemblGenomes-Tr:CCP45777,InterPro:IPR011089,UniProtKB/TrEMBL:I6X5W6,NCBI_GP:CCP45777.1;Name=CCP45777.1;Note=Rv2972c%2C (MTCY349.15)%2C len: 237 aa. Possible conserved membrane or exported protein%2C equivalent (but longer 52 aa) to O69461|MLCB1243.02 hypothetical 20.5 KDA protein from Mycobacterium leprae (180 aa)%2C FASTA scores: opt: 581%2C E(): 8.2e-32%2C (55.75%25 identity in 174 aa overlap). Also similar to membrane or exported proteins e.g. Q9F2P3|SCE41.16C putative lipoprotein from Streptomyces coelicolor (258 aa)%2C FASTA scores: opt: 498%2CE(): 4.1e-26%2C (44.08%25 identity in 186 aa overlap)%3B Q99QB5|SCP1.323C putative secreted protein from Streptomyces coelicolor (219 aa)%2C FASTA scores: opt: 329%2CE(): 8.5e-15%2C (36.35%25 identity in 176 aa overlap)%3B Q9ACQ1|SCP1.267 putative secreted protein from Streptomyces coelicolor (219 aa)%2C FASTA scores: opt: 286%2C E(): 6.6e-12%2C(32.03%25 identity in 231 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2972c;product=Possible conserved membrane or exported protein;protein_id=CCP45777.1;transl_table=11
AL123456.3	EMBL	gene	3327733	3329946	.	-	.	ID=gene-Rv2973c;Name=recG;gbkey=Gene;gene=recG;gene_biotype=protein_coding;locus_tag=Rv2973c
AL123456.3	EMBL	CDS	3327733	3329946	.	-	0	ID=cds-CCP45778.1;Parent=gene-Rv2973c;Dbxref=EnsemblGenomes-Gn:Rv2973c,EnsemblGenomes-Tr:CCP45778,GOA:P9WMQ7,InterPro:IPR001650,InterPro:IPR004609,InterPro:IPR011545,InterPro:IPR012340,InterPro:IPR014001,InterPro:IPR027417,NCBI_GP:CCP45778.1;Name=CCP45778.1;Note=Rv2973c%2C (MTCY349.14)%2C len: 737 aa. Probable recG%2CATP-dependent DNA helicase (see citation below)%2C equivalent to O69460|RECG_MYCLE ATP-dependent DNA helicase from Mycobacterium leprae (743 aa)%2C FASTA scores: opt: 3846%2CE(): 0%2C (79.3%25 identity in 744 aa overlap). Also highly similar to others e.g. Q9ZBR3|SC7A1.10 putative ATP-dependent DNA helicase from Streptomyces coelicolor (742 aa)%2C FASTA scores: opt: 1249%2C E(): 1.1e-67%2C (46.2%25 identity in 758 aa overlap)%3B Q9PGE8 ATP-dependent DNA helicase from Xylella fastidiosa (718 aa)%2C FASTA scores: opt: 1174%2C E(): 3.5e-63%2C (42.1%25 identity in 539 aa overlap)%3B P24230|RECG_ECOLI|RECG|B3652 from Escherichia coli strain K12 (693 aa)%2C FASTA scores: opt: 457%2C E(): 7.3e-22%2C (35.2%25 identity in 733 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the helicase family%2C RECG subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=recG;inference=protein motif:PROSITE:PS00017;locus_tag=Rv2973c;product=Probable ATP-dependent DNA helicase RecG;protein_id=CCP45778.1;transl_table=11
AL123456.3	EMBL	gene	3329949	3331361	.	-	.	ID=gene-Rv2974c;Name=Rv2974c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2974c
AL123456.3	EMBL	CDS	3329949	3331361	.	-	0	ID=cds-CCP45779.1;Parent=gene-Rv2974c;Dbxref=EnsemblGenomes-Gn:Rv2974c,EnsemblGenomes-Tr:CCP45779,GOA:I6Y259,InterPro:IPR004007,InterPro:IPR019986,UniProtKB/TrEMBL:I6Y259,NCBI_GP:CCP45779.1;Name=CCP45779.1;Note=Rv2974c%2C (MTCY349.13)%2C len: 470 aa. Conserved hypothetical ala-rich protein%2C highly similar to others e.g. C-terminus of Q9ZBR4|SC7A1.09 hypothetical 59.5 KDA protein from Streptomyces coelicolor (589 aa)%2C FASTA scores: opt: 774%2C E(): 1.3e-36%2C (41.0%25 identity in 495 aa overlap)%3B Q9K9Z6|BH2498 hypothetical protein from Bacillus halodurans (557 aa)%2C FASTA scores: opt: 268%2C E(): 8e-08%2C(27.7%25 identity in 502 aa overlap) (N-terminus longer 76 aa)%3B Q9X293 conserved hypothetical protein from Thermotoga maritima (497 aa)%2C FASTA scores: opt: 265%2C E(): 1.1e-07%2C(24.9%25 identity in 470 aa overlap) (N-terminus longer 43 aa)%3B etc. Also some similarity with P47609|Y369_MYCGE|MG369 hypothetical protein from Mycoplasma genitalium (557 aa)%2CFASTA scores: opt: 154%2C E(): 0.25%2C (20.25%25 identity in 489 aa overlap)%3B this%2C and following ORF%2C are similar to Y369_MYCGE but no cosmid sequence error was identified.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2974c;product=Conserved hypothetical alanine rich protein;protein_id=CCP45779.1;transl_table=11
AL123456.3	EMBL	gene	3331358	3331612	.	-	.	ID=gene-Rv2975c;Name=Rv2975c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2975c
AL123456.3	EMBL	CDS	3331358	3331612	.	-	0	ID=cds-CCP45780.1;Parent=gene-Rv2975c;Dbxref=EnsemblGenomes-Gn:Rv2975c,EnsemblGenomes-Tr:CCP45780,GOA:P95120,InterPro:IPR004007,UniProtKB/TrEMBL:P95120,NCBI_GP:CCP45780.1;Name=CCP45780.1;Note=Rv2975c%2C (MTCY349.12)%2C len: 84 aa. Conserved hypothetical protein%2C similar to N-terminus of others e.g. Q9ZBR4|SC7A1.09 hypothetical 59.5 KDA protein from Streptomyces coelicolor (589 aa)%2C FASTA scores: opt: 141%2CE(): 0.0019%2C (41.25%25 identity in 80 aa overlap)%3B Q98R49|MYPU_1610 hypothetical protein from Mycoplasma pulmonis (545 aa)%2C FASTA scores: opt: 127%2C E(): 0.023%2C(48.0%25 identity in 50 aa overlap)%3B Q9K9Z6|BH2498 hypothetical protein from Bacillus halodurans (557 aa)%2CFASTA scores: opt: 126%2C E(): 0.028%2C (34.55%25 identity in 81 aa overlap)%3B etc. Also some similarity with N-terminus of P47609|Y369_MYCGE|MG369 hypothetical protein from Mycoplasma genitalium (557 aa)%2C FASTA scores: opt: 108%2CE(): 0.7%2C (36.75%25 identity in 49 aa overlap)%3B this%2C and preceding ORF%2C are similar to Y369_MYCGE and YLOV protein but no cosmid sequence error was identified.;gbkey=CDS;locus_tag=Rv2975c;product=Conserved hypothetical protein;protein_id=CCP45780.1;transl_table=11
AL123456.3	EMBL	gene	3332071	3332754	.	-	.	ID=gene-Rv2976c;Name=ung;gbkey=Gene;gene=ung;gene_biotype=protein_coding;locus_tag=Rv2976c
AL123456.3	EMBL	CDS	3332071	3332754	.	-	0	ID=cds-CCP45781.1;Parent=gene-Rv2976c;Dbxref=EnsemblGenomes-Gn:Rv2976c,EnsemblGenomes-Tr:CCP45781,GOA:P9WFQ9,InterPro:IPR002043,InterPro:IPR005122,InterPro:IPR018085,PDB:2ZHX,PDB:3A7N,NCBI_GP:CCP45781.1;Name=CCP45781.1;Note=Rv2976c%2C (MTCY349.11)%2C len: 227 aa. Probable ung%2Curacil-DNA glycosylase (see citation below)%2C equivalent to Q9CBS3 uracil-DNA glycosylase from Mycobacterium leprae (227 aa)%2C FASTA scores: opt: 1394%2C E(): 8.8e-85%2C (88.1%25 identity in 227 aa overlap). Also highly similar to others e.g. Q9EX12 from Streptomyces coelicolor (225 aa)%2C FASTA scores: opt: 1134%2C E(): 1.3e-67%2C (72.75%25 identity in 224 aa overlap)%3B Q9K682|UNG_BACHD from Bacillus halodurans (224 aa)%2C FASTA scores: opt: 652%2C E(): 8.9e-36%2C (45.5%25 identity in 222 aa overlap)%3B P39615|UNG_BACSU from Bacillus subtilis (225 aa)%2C FASTA scores: opt: 625%2C E(): 5.4e-34%2C (45.5%25 identity in 222 aa overlap)%3B etc. Belongs to the uracil-DNA glycosylase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ung;locus_tag=Rv2976c;product=Probable uracil-DNA glycosylase Ung (UDG);protein_id=CCP45781.1;transl_table=11
AL123456.3	EMBL	gene	3332787	3333788	.	-	.	ID=gene-Rv2977c;Name=thiL;gbkey=Gene;gene=thiL;gene_biotype=protein_coding;locus_tag=Rv2977c
AL123456.3	EMBL	CDS	3332787	3333788	.	-	0	ID=cds-CCP45782.1;Parent=gene-Rv2977c;Dbxref=EnsemblGenomes-Gn:Rv2977c,EnsemblGenomes-Tr:CCP45782,GOA:P9WG71,InterPro:IPR000728,InterPro:IPR006283,InterPro:IPR010918,InterPro:IPR016188,NCBI_GP:CCP45782.1;Name=CCP45782.1;Note=Rv2977c%2C (MTCY349.10)%2C len: 333 aa. Possible thiL%2Cthiamin-monophosphate kinase%2C equivalent to Q9CBS2 probable thiamine-monophosphate kinase from Mycobacterium leprae (325 aa)%2C FASTA scores: opt: 1738%2C E(): 4.5e-98%2C (80.9%25 identity in 314 aa overlap). Also highly similar to others e.g. Q9ZBR7|SC7A1.06 putative thiamine monphosphate kinase from Streptomyces coelicolor (322 aa)%2C FASTA scores: opt: 959%2C E(): 7.8e-51%2C (51.1%25 identity in 319 aa overlap)%3B O05514|THIL_BACSU thiamine-monophosphate kinase from Bacillus subtilis (325 aa)%2C FASTA scores: opt: 476%2C E(): 1.5e-21%2C (35.15%25 identity in 273 aa overlap)%3B P77785|THIL_ECOLI|THIL|B0417 thiamine-monophosphate kinase from Escherichia coli strain K12 (325 aa)%2C FASTA scores: opt: 418%2C E(): 5e-18%2C (36.9%25 identity in 282 aa overlap)%3B etc. Belongs to the thiamine-monophosphate kinase family. Note that the start%2C as given%2C is in IS1538.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=thiL;locus_tag=Rv2977c;product=Probable thiamine-monophosphate kinase ThiL (thiamine-phosphate kinase);protein_id=CCP45782.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3333768	3335792	.	-	.	ID=id-AL123456.3:3333768..3335792;Note=IS1538%2C len: 2025 nt. Similar to other Insertion sequence elements in M. tuberculosis e.g. IS1535%2C IS1536%2CIS1537%2C %26 IS1539 (EM_NEW:MTCY274 Z74024 Mycobacterium tuberculosis cosmid Y274);gbkey=mobile_element;mobile_element_type=insertion sequence:IS1538
AL123456.3	EMBL	repeat_region	3333768	3333773	.	+	.	ID=id-AL123456.3:3333768..3333773;Note=6 bp inverted repeat at the left end of IS1538%2CTGAGTG;gbkey=repeat_region
AL123456.3	EMBL	gene	3333785	3335164	.	-	.	ID=gene-Rv2978c;Name=Rv2978c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2978c
AL123456.3	EMBL	CDS	3333785	3335164	.	-	0	ID=cds-CCP45783.1;Parent=gene-Rv2978c;Dbxref=EnsemblGenomes-Gn:Rv2978c,EnsemblGenomes-Tr:CCP45783,InterPro:IPR001959,InterPro:IPR010095,InterPro:IPR021027,UniProtKB/TrEMBL:I6Y263,NCBI_GP:CCP45783.1;Name=CCP45783.1;Note=Rv2978c%2C (MTCY349.09)%2C len: 459 aa. Probable transposase for IS1538%2C very similar to several other putative transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809 (460 aa)%2C FASTA scores: opt: 2613%2C E(): 0%2C (83.0%25 identity in 458 aa overlap)%3B etc. Low level matches to other tranposases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2978c;product=Probable transposase;protein_id=CCP45783.1;transl_table=11
AL123456.3	EMBL	gene	3335164	3335748	.	-	.	ID=gene-Rv2979c;Name=Rv2979c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2979c
AL123456.3	EMBL	CDS	3335164	3335748	.	-	0	ID=cds-CCP45784.1;Parent=gene-Rv2979c;Dbxref=EnsemblGenomes-Gn:Rv2979c,EnsemblGenomes-Tr:CCP45784,GOA:I6XFU1,InterPro:IPR006118,InterPro:IPR006119,UniProtKB/TrEMBL:I6XFU1,NCBI_GP:CCP45784.1;Name=CCP45784.1;Note=Rv2979c%2C (MTCY349.08)%2C len: 194 aa. Probable resolvase for IS1538%2C with low level matches to transposon resolvases%3B highly similar from aa 101 to YX1C_MYCTU|Q10831 from Mycobacterium tuberculosis (295 aa)%2C FASTA scores: opt: 809%2C E(): 0%2C (69.1%25 identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site%2Cand possible helix-turn-helix motiv at aa 2-23.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00397;locus_tag=Rv2979c;product=Probable resolvase;protein_id=CCP45784.1;transl_table=11
AL123456.3	EMBL	repeat_region	3335787	3335792	.	-	.	ID=id-AL123456.3:3335787..3335792;Note=6 bp inverted repeat at the right end of IS1538%2CTGAGTG.;gbkey=repeat_region
AL123456.3	EMBL	gene	3335960	3336505	.	+	.	ID=gene-Rv2980;Name=Rv2980;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2980
AL123456.3	EMBL	CDS	3335960	3336505	.	+	0	ID=cds-CCP45785.1;Parent=gene-Rv2980;Dbxref=EnsemblGenomes-Gn:Rv2980,EnsemblGenomes-Tr:CCP45785,InterPro:IPR021903,UniProtKB/TrEMBL:P95115,NCBI_GP:CCP45785.1;Name=CCP45785.1;Note=Rv2980%2C (MTCY349.07c)%2C len: 181 aa. Possible conserved secreted protein%2C equivalent to Q9CBS1 possible secreted protein from Mycobacterium leprae (191 aa)%2C FASTA scores: opt: 794%2C E(): 2.3e-40%2C (67.25%25 identity in 177 aa overlap). Also some weak similarity with other hypothetical proteins or secreted proteins e.g. C-terminus of Q98F98|MLL3872 MLL3872 protein from Rhizobium loti (Mesorhizobium loti) (575 aa)%2C FASTA scores: opt: 148%2C E(): 0.16%2C (28.35%25 identity in 194 aa overlap)%3B Q9L0W9|SCH22A.13C putative secreted protein from Streptomyces coelicolor (167 aa)%2C FASTA scores: opt: 114%2CE(): 7.5%2C (40.0%25 identity in 80 aa overlap)%3B etc. Equivalent to AAK47385 from Mycobacterium tuberculosis strain CDC1551 (214 aa) but shorter 33 aa. Has hydrophobic stretch near N-terminus. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2980;product=Possible conserved secreted protein;protein_id=CCP45785.1;transl_table=11
AL123456.3	EMBL	gene	3336796	3337917	.	-	.	ID=gene-Rv2981c;Name=ddlA;gbkey=Gene;gene=ddlA;gene_biotype=protein_coding;gene_synonym=ddl;locus_tag=Rv2981c
AL123456.3	EMBL	CDS	3336796	3337917	.	-	0	ID=cds-CCP45786.1;Parent=gene-Rv2981c;Dbxref=EnsemblGenomes-Gn:Rv2981c,EnsemblGenomes-Tr:CCP45786,GOA:P9WP31,InterPro:IPR000291,InterPro:IPR005905,InterPro:IPR011095,InterPro:IPR011127,InterPro:IPR011761,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,PDB:3LWB,NCBI_GP:CCP45786.1;Name=CCP45786.1;Note=Rv2981c%2C (MTCY349.06)%2C len: 373 aa. Probable ddlA (alternate gene name: ddl)%2C D-alanine--D-alanine ligase a (see citation below)%2C equivalent to Q9CBS0|Q9CBS0 D-alanine-D-alanine ligase a from Mycobacterium leprae (384 aa)%2C FASTA scores: opt: 2001%2C E(): 2.4e-115%2C (81.75%25 identity in 367 aa overlap)%3B and Q9ZGN0|DDL_MYCSM D-alanine--D-alanine ligase from Mycobacterium smegmatis (373 aa)%2C FASTA scores: opt: 1934%2C E(): 3.1e-111%2C (77.95%25 identity in 372 aa overlap). Also highly similar to others e.g. Q9ZBR9|DDL_STRCO from Streptomyces coelicolor (389 aa)%2C FASTA scores: opt: 1187%2C E(): 2.2e-65%2C (52.0%25 identity in 379 aa overlap)%3B P15051|DDLA_SALTY from Salmonella typhimurium and Salmonella typhi (363 aa)%2C FASTA scores: opt: 946%2C E(): 1.3e-50%2C (44.5%25 identity in 364 aa overlap)%3B P23844|DDLA_ECOLI|DDLA|B0381|Z0477|ECS0431 from Escherichia coli strain O157:H7 and K12 (364 aa)%2C FASTA scores: opt: 938%2C E(): 3.9e-50%2C (43.55%25 identity in 363 aa overlap)%3B etc. Contains PS00843 D-alanine--D-alanine ligase signature 1. Belongs to the D-alanine--D-alanine ligase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ddlA;inference=protein motif:PROSITE:PS00843;locus_tag=Rv2981c;product=Probable D-alanine--D-alanine ligase DdlA (D-alanylalanine synthetase) (D-ala-D-ala ligase);protein_id=CCP45786.1;transl_table=11
AL123456.3	EMBL	gene	3337995	3338999	.	-	.	ID=gene-Rv2982c;Name=gpdA2;gbkey=Gene;gene=gpdA2;gene_biotype=protein_coding;gene_synonym=gpsA;locus_tag=Rv2982c
AL123456.3	EMBL	CDS	3337995	3338999	.	-	0	ID=cds-CCP45787.1;Parent=gene-Rv2982c;Dbxref=EnsemblGenomes-Gn:Rv2982c,EnsemblGenomes-Tr:CCP45787,GOA:P9WN77,InterPro:IPR006109,InterPro:IPR006168,InterPro:IPR008927,InterPro:IPR011128,InterPro:IPR013328,InterPro:IPR016040,NCBI_GP:CCP45787.1;Name=CCP45787.1;Note=Rv2982c%2C (MTCY349.05)%2C len: 334 aa. Probable gpdA2 (alternate gene name: gpsA)%2C glycerol-3-phosphate dehydrogenase [NAD(P)+]%2C equivalent to Q9CBR9|GPDA_MYCLE glycerol-3-phosphate dehydrogenase [NAD(P)+] from Mycobacterium leprae (349 aa)%2C FASTA scores: opt: 1686%2CE(): 1.7e-95%2C (77.95%25 identity in 349 aa overlap). Also highly similar to others e.g. Q9ZBS0|GPDA_STRCO from Streptomyces coelicolor (336 aa)%2C FASTA scores: opt: 1165%2CE(): 9.8e-64%2C (56.25%25 identity in 327 aa overlap)%3B P46919|GPDA_BACSU from Bacillus subtilis (345 aa)%2C FASTA scores: opt: 872%2C E(): 7.5e-46%2C (44.9%25 identity in 325 aa overlap)%3B P37606|GPDA_ECOLI|GPSA|B3608|Z5035|ECS4486. from Escherichia coli strain O157:H7 and K12 (339 aa)%2C FASTA scores: opt: 799%2C E(): 2.1e-41%2C (42.9%25 identity in 331 aa overlap)%3B etc. Also highly similar to O53761|GPD2_MYCTU probable glycerol-3-phosphate dehydrogenase from Mycobacterium tuberculosis (341 aa)%2C FASTA scores: opt: 740%2C E(): 8.4e-38%2C (40.35%25 identity in 322 aa overlap). Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gpdA2;locus_tag=Rv2982c;product=Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase);protein_id=CCP45787.1;transl_table=11
AL123456.3	EMBL	gene	3339118	3339762	.	+	.	ID=gene-Rv2983;Name=Rv2983;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2983
AL123456.3	EMBL	CDS	3339118	3339762	.	+	0	ID=cds-CCP45788.1;Parent=gene-Rv2983;Dbxref=EnsemblGenomes-Gn:Rv2983,EnsemblGenomes-Tr:CCP45788,GOA:P9WP83,InterPro:IPR002835,InterPro:IPR029044,NCBI_GP:CCP45788.1;Name=CCP45788.1;Note=Rv2983%2C (MTCY349.04c)%2C len: 214 aa. Conserved hypothetical ala-rich protein%2C equivalent to O33128|ML1680|MLCB637.37c hypothetical 22.0 KDA protein from Mycobacterium leprae (216 aa)%2C FASTA scores: opt: 1080%2C E(): 9e-61%2C (79.05%25 identity in 215 aa overlap). Also similar to other hypothetical proteins e.g. Q9ZBS2|SC7A1.01C from Streptomyces coelicolor (212 aa)%2CFASTA scores: opt: 420%2C E(): 2.9e-19%2C (43.5%25 identity in 207 aa overlap)%3B O26710|MTH613 from Methanothermobacter thermautotrophicus (223 aa)%2C FASTA scores: opt: 193%2C E(): 5.8e-05%2C (30.0%25 identity in 190 aa overlap)%3B Q9RKG8|SCE46.21 from Streptomyces coelicolor (210 aa)%2CFASTA scores: opt: 139%2C E(): 0.14%2C (27.65%25 identity in 206 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2983;product=Conserved hypothetical alanine rich protein;protein_id=CCP45788.1;transl_table=11
AL123456.3	EMBL	gene	3339854	3342082	.	+	.	ID=gene-Rv2984;Name=ppk1;gbkey=Gene;gene=ppk1;gene_biotype=protein_coding;locus_tag=Rv2984
AL123456.3	EMBL	CDS	3339854	3342082	.	+	0	ID=cds-CCP45789.1;Parent=gene-Rv2984;Dbxref=EnsemblGenomes-Gn:Rv2984,EnsemblGenomes-Tr:CCP45789,GOA:P9WHV9,InterPro:IPR003414,InterPro:IPR024953,InterPro:IPR025198,InterPro:IPR025200,NCBI_GP:CCP45789.1;Name=CCP45789.1;Note=Rv2984%2C (MTCY349.03c)%2C len: 742 aa. Ppk1%2Cpolyphosphate kinase (See Sureka et al.%2C 2007)%2C equivalent to O33127|PPK_MYCLE polyphosphate kinase from Mycobacterium leprae (739 aa)%2C FASTA scores: opt: 4264%2C E(): 0%2C (87.85%25 identity in 742 aa overlap). Also highly similar to others e.g. Q9KZV6|PPK_STRCO from Streptomyces coelicolor (746 aa)%2C FASTA scores: opt: 1979%2C E(): 2.6e-117%2C (59.9%25 identity in 701 aa overlap)%3B Q9KD27|PPK_BACHD from Bacillus halodurans (705 aa)%2C FASTA scores: opt: 1319%2C E(): 1.4e-75%2C(45.55%25 identity in 674 aa overlap)%3B Q9PAC7|PPK_XYLFA from Xylella fastidiosa (698 aa)%2C FASTA scores: opt: 1300%2C E(): 2.2e-74%2C (43.3%25 identity in 693 aa overlap)%3B etc. Belongs to the polyphosphate kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppk1;locus_tag=Rv2984;product=Polyphosphate kinase PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase);protein_id=CCP45789.1;transl_table=11
AL123456.3	EMBL	gene	3342165	3343118	.	+	.	ID=gene-Rv2985;Name=mutT1;gbkey=Gene;gene=mutT1;gene_biotype=protein_coding;locus_tag=Rv2985
AL123456.3	EMBL	CDS	3342165	3343118	.	+	0	ID=cds-CCP45790.1;Parent=gene-Rv2985;Dbxref=EnsemblGenomes-Gn:Rv2985,EnsemblGenomes-Tr:CCP45790,GOA:P9WIY3,InterPro:IPR000086,InterPro:IPR013078,InterPro:IPR015797,InterPro:IPR020084,InterPro:IPR020476,InterPro:IPR029033,NCBI_GP:CCP45790.1;Name=CCP45790.1;Note=Rv2985%2C (MTCY349.02c)%2C len: 317 aa. Possible mutT1%2Clong MutT protein (hydrolase) (see citation below)%2C highly similar to O33126|MLCB637.35 hypothetical 34.5 KDA protein from Mycobacterium leprae (312 aa)%2C FASTA scores: opt: 1514%2C E(): 5.1e-91%2C (71.85%25 identity in 316 aa overlap)%3B and Q9CBR8|ML1682 hypothetical protein from Mycobacterium leprae (311 aa)%2C FASTA scores: opt: 1510%2C E(): 9.2e-91%2C(71.5%25 identity in 316 aa overlap). Also similar to Q50195|L222-ORF6|ML2698 hypothetical protein from Mycobacterium leprae (251 aa)%2C FASTA scores: opt: 231%2C E(): 1.1e-07%2C (36.7%25 identity in 128 aa overlap). Also similar to shorter mutt proteins and related hypothetical protein e.g. Q9EUS6 hypothetical 16.6 KDA protein from Streptomyces griseus subsp. griseus (152 aa)%2C FASTA scores: opt: 380%2CE(): 1.7e-17%2C (50.75%25 identity in 130 aa overlap)%3B Q9KZV8|SCD84.10C putative mutt-like protein from Streptomyces coelicolor (142 aa)%2C FASTA scores: opt: 376%2CE(): 2.9e-17%2C (46.1%25 identity in 128 aa overlap)%3B P96590|mutt mutt protein from Bacillus subtilis (149 aa)%2CFASTA scores: opt: 180%2C E(): 0.00017%2C (35.25%25 identity in 122 aa overlap)%3B etc. Also similar to O05437 hypothetical 27.1 KDA protein from Mycobacterium tuberculosis (248 aa)%2CFASTA scores: opt: 224%2C E(): 3.2e-07%2C (34.03%25 identity in 144 aa overlap). Contains PS00893 mutT domain signature. Seems to belong to the mutt/NUDIX family protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mutT1;inference=protein motif:PROSITE:PS00893;locus_tag=Rv2985;product=Possible hydrolase MutT1;protein_id=CCP45790.1;transl_table=11
AL123456.3	EMBL	gene	3343176	3343820	.	-	.	ID=gene-Rv2986c;Name=hupB;gbkey=Gene;gene=hupB;gene_biotype=protein_coding;gene_synonym=hlp,hup,lbp21;locus_tag=Rv2986c
AL123456.3	EMBL	CDS	3343176	3343820	.	-	0	ID=cds-CCP45791.1;Parent=gene-Rv2986c;Dbxref=EnsemblGenomes-Gn:Rv2986c,EnsemblGenomes-Tr:CCP45791,GOA:P9WMK7,InterPro:IPR000119,InterPro:IPR010992,InterPro:IPR020816,PDB:4DKY,PDB:4PT4,NCBI_GP:CCP45791.1;Name=CCP45791.1;Note=Rv2986c%2C (MTCY349.01)%2C len: 214 aa. hupB (alternate gene names: hup%2C hlp%2C lbp21)%2C DNA-binding protein HU homolog (resembles fusion between HU and histone) (see Pethe et al.%2C 2002)%2C equivalent to others from Mycobacteria e.g. Q9XB18|DBH_MYCBO from Mycobacterium bovis (205 aa)%2CFASTA scores: opt: 1050%2C E(): 5.6e-45%2C (95.35%25 identity in 214 aa overlap)%3B Q9ZHC5|DBH_MYCSM from Mycobacterium smegmatis (208 aa)%2C FASTA scores: opt: 1035%2C E(): 3.1e-44%2C(80.2%25 identity in 217 aa overlap)%3B and O33125|DBH_MYCLE from Mycobacterium leprae (200 aa)%2C FASTA scores: opt: 914%2CE(): 2.7e-38%2C (80.1%25 identity in 216 aa overlap). Also highly similar to others from other organisms e.g. O86537|DBH2_STRCO from Streptomyces coelicolor (218 aa)%2CFASTA scores: opt: 569%2C E(): 2.6e-21%2C (51.35%25 identity in 220 aa overlap)%3B P08821|DBH1_BACSU from Bacillus subtilis (92 aa)%2C FASTA scores: opt: 280%2C E(): 2.5e-07%2C (45.05%25 identity in 91 aa overlap) (C-terminus shorter)%3B etc. Contains PS00045 Bacterial histone-like DNA-binding proteins signature. Belongs to the bacterial histone-like protein family. Note that its C-terminal domain is very rich in lysine and alanine.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hupB;inference=protein motif:PROSITE:PS00045;locus_tag=Rv2986c;product=DNA-binding protein HU homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein);protein_id=CCP45791.1;transl_table=11
AL123456.3	EMBL	gene	3344033	3344629	.	-	.	ID=gene-Rv2987c;Name=leuD;gbkey=Gene;gene=leuD;gene_biotype=protein_coding;locus_tag=Rv2987c
AL123456.3	EMBL	CDS	3344033	3344629	.	-	0	ID=cds-CCP45792.1;Parent=gene-Rv2987c;Dbxref=EnsemblGenomes-Gn:Rv2987c,EnsemblGenomes-Tr:CCP45792,GOA:P9WK95,InterPro:IPR000573,InterPro:IPR004431,InterPro:IPR015928,InterPro:IPR015937,PDB:3H5E,PDB:3H5H,PDB:3H5J,NCBI_GP:CCP45792.1;Name=CCP45792.1;Note=Rv2987c%2C (MTV012.01c)%2C len: 198 aa. Probable leuD%2C3-isopropylmalate dehydratase%2C small subunit%2C equivalent to O33124|LEUD_MYCLE 3-isopropylmalate dehydratase small subunit from Mycobacterium leprae (198 aa)%2C FASTA scores: opt: 1155%2C E(): 4.2e-72%2C (87.75%25 identity in 196 aa overlap). Also highly similar to many e.g. O86535|LEUD_STRCO from Streptomyces coelicolor (197 aa)%2CFASTA scores: opt: 765%2C E(): 2.6e-45%2C (59.0%25 identity in 195 aa overlap)%3B P04787|LEUD_SALTY from Salmonella typhimurium (201 aa)%2C FASTA scores: opt: 528%2C E(): 5.2e-29%2C(45.05%25 identity in 191 aa overlap)%3B P30126|LEUD_ECOLI|LEUD|B0071 from Escherichia coli strain K12 (201 aa)%2C FASTA scores: opt: 498%2C E(): 6e-27%2C (43.45%25 identity in 191 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=leuD;locus_tag=Rv2987c;product=Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI);protein_id=CCP45792.1;transl_table=11
AL123456.3	EMBL	gene	3344654	3346075	.	-	.	ID=gene-Rv2988c;Name=leuC;gbkey=Gene;gene=leuC;gene_biotype=protein_coding;locus_tag=Rv2988c
AL123456.3	EMBL	CDS	3344654	3346075	.	-	0	ID=cds-CCP45793.1;Parent=gene-Rv2988c;Dbxref=EnsemblGenomes-Gn:Rv2988c,EnsemblGenomes-Tr:CCP45793,GOA:P9WQF5,InterPro:IPR001030,InterPro:IPR004430,InterPro:IPR015931,InterPro:IPR015932,InterPro:IPR015937,InterPro:IPR018136,NCBI_GP:CCP45793.1;Name=CCP45793.1;Note=Rv2988c%2C (MTV012.02c)%2C len: 473 aa. Probable leuC%2C3-isopropylmalate dehydratase%2C large subunit%2C equivalent to O33123|LEU2_MYCLE 3-isopropylmalate dehydratase small subunit from Mycobacterium leprae (476 aa)%2C FASTA scores: opt: 2818%2C E(): 1.3e-171%2C (88.75%25 identity in 471 aa overlap). Also highly similar to many e.g. Q44427|LEU2_ACTTI from Actinoplanes teichomyceticus (485 aa)%2C FASTA scores: opt: 1958%2C E(): 6.5e-117%2C (71.0%25 identity in 479 aa overlap)%3B P55251|LEU2_RHIPU from Rhizomucor pusillus (755 aa)%2C FASTA scores: opt: 1937%2C E(): 1.9e-115%2C (61.25%25 identity in 467 aa overlap) (C-terminus longer)%3B P30127|LEU2_ECOLI|LEUC|B0072 from Escherichia coli strain K12 (465 aa)%2C FASTA scores: opt: 1896%2C E(): 5.5e-113%2C (61.6%25 identity in 456 aa overlap)%3B etc. Contains PS00450 Aconitase family signature. Belongs to the aconitase/IPM isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=leuC;inference=protein motif:PROSITE:PS00450;locus_tag=Rv2988c;product=Probable 3-isopropylmalate dehydratase (large subunit) LeuC (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI);protein_id=CCP45793.1;transl_table=11
AL123456.3	EMBL	gene	3346147	3346848	.	+	.	ID=gene-Rv2989;Name=Rv2989;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2989
AL123456.3	EMBL	CDS	3346147	3346848	.	+	0	ID=cds-CCP45794.1;Parent=gene-Rv2989;Dbxref=EnsemblGenomes-Gn:Rv2989,EnsemblGenomes-Tr:CCP45794,GOA:O53238,InterPro:IPR005471,InterPro:IPR011991,InterPro:IPR014757,InterPro:IPR029016,UniProtKB/TrEMBL:O53238,NCBI_GP:CCP45794.1;Name=CCP45794.1;Note=Rv2989%2C (MTV012.03)%2C len: 233 aa. Probable transcriptional regulator (ala-rich protein)%2C highly similar to O86533|SC1C2.33c putative transcriptional regulator from Streptomyces coelicolor (238 aa)%2C FASTA scores: opt: 711%2C E(): 2.3e-38%2C (53.05%25 identity in 230 aa overlap)%3B and similar to others e.g. Q9KND6 putative transcriptional regulator from Vibrio cholerae (244 aa)%2CFASTA scores: opt: 232%2C E(): 1.2e-07%2C (29.75%25 identity in 232 aa overlap)%3B Q9R9U0|SRPS efflux pump regulator from Pseudomonas putida (259 aa)%2C FASTA scores: opt: 224%2C E(): 4.1e-07%2C (28.35%25 identity in 247 aa overlap)%3B etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O06806|Rv1773c|MTCY28.39 hypothetical 26.6 KDA protein (248 aa)%2C FASTA scores: opt: 239%2C E(): 4.4e-08%2C (29.85%25 identity in 231 aa overlap)%3B P71977|RV1719|MTCY04C12.04 hypothetical 27.9 KDA protein (259 aa)%2C FASTA scores: opt: 215%2C E(): 1.6e-06%2C (31.85%25 identity in 223 aa overlap)%3B etc. Equivalent to AAK47396 from Mycobacterium tuberculosis strain CDC1551 (267 aa) but shorter 34 aa. Contains possible helix-turn-helix motif at aa 25-46 (Score 1005%2C+2.61 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2989;product=Probable transcriptional regulatory protein;protein_id=CCP45794.1;transl_table=11
AL123456.3	EMBL	gene	3346859	3347719	.	-	.	ID=gene-Rv2990c;Name=Rv2990c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2990c
AL123456.3	EMBL	CDS	3346859	3347719	.	-	0	ID=cds-CCP45795.1;Parent=gene-Rv2990c;Dbxref=EnsemblGenomes-Gn:Rv2990c,EnsemblGenomes-Tr:CCP45795,InterPro:IPR029063,UniProtKB/TrEMBL:I6YEW1,NCBI_GP:CCP45795.1;Name=CCP45795.1;Note=Rv2990c%2C (MTV012.04c)%2C len: 286 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv2990c;product=Hypothetical protein;protein_id=CCP45795.1;transl_table=11
AL123456.3	EMBL	gene	3347982	3348473	.	+	.	ID=gene-Rv2991;Name=Rv2991;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2991
AL123456.3	EMBL	CDS	3347982	3348473	.	+	0	ID=cds-CCP45796.1;Parent=gene-Rv2991;Dbxref=EnsemblGenomes-Gn:Rv2991,EnsemblGenomes-Tr:CCP45796,GOA:O53240,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019920,PDB:1RFE,UniProtKB/TrEMBL:O53240,NCBI_GP:CCP45796.1;Name=CCP45796.1;Note=Rv2991%2C (MTV012.05)%2C len: 163 aa. Conserved protein%2Csimilar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa)%2C FASTA scores: opt: 266%2C E(): 2.1e-11%2C (34.85%25 identity in 155 aa overlap)%3B Q9CNX3|PM0299 hypothetical protein from Pasteurella multocida (171 aa)%2C FASTA scores: opt: 175%2CE(): 5.1e-05%2C (31.3%25 identity in 131 aa overlap)%3B Q9KZI9|SCG8A.10 conserved hypothetical protein from Streptomyces coelicolor (142 aa)%2C FASTA scores: opt: 163%2CE(): 0.00031%2C (32.4%25 identity in 108 aa overlap)%3B etc. Also some similarity to O06553|MTCI65.22|Rv1155 hypothetical protein from Mycobacterium tuberculosis (147 aa)%2C FASTA scores: opt: 127%2C E(): 0.1%2C (32.9%25 identity in 73 aa overlap)%3B and to several proteins of similar size that confer resistance to 5-Nitroimidazole antibiotics in Bacteroides.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2991;product=Conserved protein;protein_id=CCP45796.1;transl_table=11
AL123456.3	EMBL	gene	3348547	3348619	.	-	.	ID=gene-gluU;Name=gluU;gbkey=Gene;gene=gluU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	3348547	3348619	.	-	.	ID=rna-gluU;Parent=gene-gluU;Note=codon recognized: GAG%3B gluU%2C tRNA-Glu%3B anticodon ctc%2C length %3D 73;anticodon=(pos:complement(3348583..3348585));gbkey=tRNA;gene=gluU;product=tRNA-Glu
AL123456.3	EMBL	exon	3348547	3348619	.	-	.	ID=exon-gluU-1;Parent=rna-gluU;Note=codon recognized: GAG%3B gluU%2C tRNA-Glu%3B anticodon ctc%2C length %3D 73;anticodon=(pos:complement(3348583..3348585));gbkey=tRNA;gene=gluU;product=tRNA-Glu
AL123456.3	EMBL	gene	3348659	3348730	.	-	.	ID=gene-glnU;Name=glnU;gbkey=Gene;gene=glnU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	3348659	3348730	.	-	.	ID=rna-glnU;Parent=gene-glnU;Note=codon recognized: CAG%3B glnU%2C tRNA-Gln%3B anticodon ctg%2C length %3D 72;anticodon=(pos:complement(3348695..3348697));gbkey=tRNA;gene=glnU;product=tRNA-Gln
AL123456.3	EMBL	exon	3348659	3348730	.	-	.	ID=exon-glnU-1;Parent=rna-glnU;Note=codon recognized: CAG%3B glnU%2C tRNA-Gln%3B anticodon ctg%2C length %3D 72;anticodon=(pos:complement(3348695..3348697));gbkey=tRNA;gene=glnU;product=tRNA-Gln
AL123456.3	EMBL	gene	3348805	3350277	.	-	.	ID=gene-Rv2992c;Name=gltS;gbkey=Gene;gene=gltS;gene_biotype=protein_coding;gene_synonym=gltX;locus_tag=Rv2992c
AL123456.3	EMBL	CDS	3348805	3350277	.	-	0	ID=cds-CCP45797.1;Parent=gene-Rv2992c;Dbxref=EnsemblGenomes-Gn:Rv2992c,EnsemblGenomes-Tr:CCP45797,GOA:P9WFV9,InterPro:IPR000924,InterPro:IPR004527,InterPro:IPR008925,InterPro:IPR014729,InterPro:IPR020058,InterPro:IPR020061,InterPro:IPR020751,PDB:2JA2,PDB:3PNV,PDB:3PNY,NCBI_GP:CCP45797.1;Name=CCP45797.1;Note=Rv2992c%2C (MTV012.06c)%2C len: 490 aa. GltS (alternate gene name: gltX)%2C glutamyl-tRNA synthase%2C equivalent to O33120|SYE_MYCLE glutamyl-tRNA synthetase from Mycobacterium leprae (502 aa)%2C FASTA scores: opt: 2660%2CE(): 2.3e-163%2C (81.35%25 identity in 488 aa overlap). Also highly similar to others e.g. O86528|SYE_STRCO from Streptomyces coelicolor (494 aa)%2C FASTA scores: opt: 1777%2CE(): 1.4e-106%2C (57.45%25 identity in 484 aa overlap)%3B P22250|SYE_BACSU from Bacillus subtilis (483 aa)%2C FASTA scores: opt: 1099%2C E(): 5.4e-63%2C (38.45%25 identity in 489 aa overlap)%3B O51345|SYE_BORBU|GLTX|BB0372 from Borrelia burgdorferi (Lyme disease spirochete) (490 aa)%2C FASTA scores: opt: 1009%2C E(): 3.3e-57%2C (34.85%25 identity in 491 aa overlap)%3B etc. Belongs to class-I aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gltS;locus_tag=Rv2992c;product=Glutamyl-tRNA synthetase GltS (glutamate--tRNA ligase) (glutamyl-tRNA synthase) (GLURS);protein_id=CCP45797.1;transl_table=11
AL123456.3	EMBL	gene	3350274	3350993	.	-	.	ID=gene-Rv2993c;Name=Rv2993c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2993c
AL123456.3	EMBL	CDS	3350274	3350993	.	-	0	ID=cds-CCP45798.1;Parent=gene-Rv2993c;Dbxref=EnsemblGenomes-Gn:Rv2993c,EnsemblGenomes-Tr:CCP45798,GOA:I6Y276,InterPro:IPR002529,InterPro:IPR011234,InterPro:IPR018833,UniProtKB/TrEMBL:I6Y276,NCBI_GP:CCP45798.1;Name=CCP45798.1;Note=Rv2993c%2C (MTV012.07c)%2C len: 239 aa. Possible 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase%2C equivalent to O33119|ML1689|MLCB637.28 possible 2-hydroxyhepta-2%2C4-diene- 1%2C7-dioate isomerase from Mycobacterium leprae (242 aa)%2C FASTA scores: opt: 1427%2CE(): 4.4e-86%2C (85.9%25 identity in 241 aa overlap). Also similar to others e.g. Q9LBE3|DR1609 from Deinococcus radiodurans (250 aa)%2C FASTA scores: opt: 723%2C E(): 5.5e-40%2C(49.05%25 identity in 216 aa overlap)%3B O27551|MTH1507 from Methanothermobacter thermautotrophicus (260 aa)%2C FASTA scores: opt: 708%2C E(): 5.4e-39%2C (52.1%25 identity in 213 aa overlap)%3B Q9HQR6|VNG1037G|HPCE from Halobacterium sp. (strain NRC-1) (244 aa)%2C FASTA scores: opt: 590%2C E(): 2.7e-31%2C (43.65%25 identity in 220 aa overlap)%3B etc. Start chosen by homology%2C but ORF could continue upstream.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2993c;product=Possible 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase (HHDD isomerase);protein_id=CCP45798.1;transl_table=11
AL123456.3	EMBL	gene	3351269	3352606	.	+	.	ID=gene-Rv2994;Name=Rv2994;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2994
AL123456.3	EMBL	CDS	3351269	3352606	.	+	0	ID=cds-CCP45799.1;Parent=gene-Rv2994;Dbxref=EnsemblGenomes-Gn:Rv2994,EnsemblGenomes-Tr:CCP45799,GOA:P9WJW7,InterPro:IPR011701,InterPro:IPR016196,InterPro:IPR020846,NCBI_GP:CCP45799.1;Name=CCP45799.1;Note=Rv2994%2C (MTV012.08)%2C len: 445 aa. Probable conserved integral membrane protein%2C member of major facilitator superfamily (MFS) possibly involved in transport of drug. C-terminal part highly similar to O33118|MLCB637.27c hypothetical 14.7 KDA protein (probable pseudogene product) from Mycobacterium leprae (134 aa)%2C FASTA scores: opt: 483%2CE(): 2.7e-21%2C (60.9%25 identity in 138 aa overlap). Also similar to various transporters e.g. Q9I5C8|PA0811 probable MFS transporter from Pseudomonas aeruginosa (415 aa)%2C FASTA scores: opt: 289%2C E(): 1.3e-09%2C (26.05%25 identity in 399 aa overlap)%3B O30210|AF0025 cyanate transport protein from Archaeoglobus fulgidus (393 aa)%2C FASTA scores: opt: 281%2CE(): 3.7e-09%2C (24.05%25 identity in 399 aa overlap)%3B Q9RI35|SCJ12.25C putative nitrate/nitrite transporter from Streptomyces coelicolor (412 aa)%2C FASTA scores: opt: 264%2CE(): 3.8e-08%2C (24.95%25 identity in 409 aa overlap)%3B Q9A5N5|CC2412 major facilitator family transporter from Caulobacter crescentus (405 aa)%2C FASTA scores: opt: 263%2CE(): 4.3e-08%2C (27.55%25 identity in 399 aa overlap)%3B etc. First start taken%3B similarity to P21191|NORA_STAAU quinolone resistance protein from Staphylococcus aureus (388 aa) suggests alternative start at 7319 but then no positively charged aa before first transmembrane segment.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2994;product=Probable conserved integral membrane protein;protein_id=CCP45799.1;transl_table=11
AL123456.3	EMBL	gene	3352458	3353468	.	-	.	ID=gene-Rv2995c;Name=leuB;gbkey=Gene;gene=leuB;gene_biotype=protein_coding;locus_tag=Rv2995c
AL123456.3	EMBL	CDS	3352458	3353468	.	-	0	ID=cds-CCP45800.1;Parent=gene-Rv2995c;Dbxref=EnsemblGenomes-Gn:Rv2995c,EnsemblGenomes-Tr:CCP45800,GOA:P9WKK9,InterPro:IPR001804,InterPro:IPR019818,InterPro:IPR023698,InterPro:IPR024084,PDB:1W0D,PDB:2G4O,NCBI_GP:CCP45800.1;Name=CCP45800.1;Note=Rv2995c%2C (MTV012.09)%2C len: 336 aa. Probable leuB%2C3-isopropylmalate dehydrogenase%2C identical except a single bp to P94929|LEU3_MYCBO 3-isopropylmalate dehydrogenase from Mycobacterium bovis (336 aa) (see citation below)%2CFASTA scores: opt: 2168%2C E(): 5.1e-132%2C (99.7%25 identity in 336 aa overlap)%3B and equivalent to O33117|LEU3_MYCLE 3-isopropylmalate dehydrogenase from Mycobacterium leprae (336 aa)%2C FASTA scores: opt: 1864%2C E(): 1.8e-112%2C (83.95%25 identity in 336 aa overlap). Also highly similar to others e.g. P94631|LEU3_CORGL from Corynebacterium glutamicum (340 aa)%2C FASTA scores: opt: 1526%2C E(): 1e-90%2C (69.9%25 identity in 339 aa overlap)%3B O86504 from Streptomyces coelicolor (347 aa)%2C FASTA scores: opt: 1470%2C E(): 4.2e-87%2C (67.85%25 identity in 339 aa overlap)%3B Q9UZ05|PAB2424 from Pyrococcus abyssi (354 aa)%2C FASTA scores: opt: 998%2C E(): 1e-56%2C (50.0%25 identity in 322 aa overlap)%3B etc. Note that also shows high similarity with many tartrate dehydrogenases. Belongs to the isocitrate and isopropylmalate dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=leuB;locus_tag=Rv2995c;product=Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH);protein_id=CCP45800.1;transl_table=11
AL123456.3	EMBL	gene	3353483	3355069	.	-	.	ID=gene-Rv2996c;Name=serA1;gbkey=Gene;gene=serA1;gene_biotype=protein_coding;gene_synonym=serA;locus_tag=Rv2996c
AL123456.3	EMBL	CDS	3353483	3355069	.	-	0	ID=cds-CCP45801.1;Parent=gene-Rv2996c;Dbxref=EnsemblGenomes-Gn:Rv2996c,EnsemblGenomes-Tr:CCP45801,GOA:P9WNX3,InterPro:IPR002912,InterPro:IPR006139,InterPro:IPR006140,InterPro:IPR006236,InterPro:IPR016040,InterPro:IPR029009,InterPro:IPR029752,InterPro:IPR029753,PDB:1YGY,PDB:3DC2,PDB:3DDN,NCBI_GP:CCP45801.1;Name=CCP45801.1;Note=Rv2996c%2C (MTV012.10)%2C len: 528 aa. Probable serA1%2CD-3-phosphoglycerate dehydrogenase%2C equivalent to SERA_MYCLE D-3-phosphoglycerate dehydrogenase from Mycobacterium leprae (528 aa)%2C FASTA scores: opt: 2974%2CE(): 1.9e-166%2C (89.6%25 identity in 528 aa overlap). Also highly similar to many e.g. Q9Z564 from Streptomyces coelicolor (529 aa)%2C FASTA scores: opt: 1879%2C E(): 2.1e-102%2C (57.6%25 identity in 526 aa overlap)%3B O29445|SERA_ARCFU from Archaeoglobus fulgidus (527 aa)%2CFASTA scores: opt: 1252%2C E(): 9.6e-66%2C (41.3%25 identity in 530 aa overlap)%3B P35136|SERA_BACSU from Bacillus subtilis (525 aa)%2C FASTA scores: opt: 1172%2C E(): 4.5e-61%2C (37.9%25 identity in 528 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature%2C and PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenases family. Note that previously known as serA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=serA1;inference=protein motif:PROSITE:PS00670;locus_tag=Rv2996c;product=Probable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH);protein_id=CCP45801.1;transl_table=11
AL123456.3	EMBL	gene	3355099	3356541	.	+	.	ID=gene-Rv2997;Name=Rv2997;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2997
AL123456.3	EMBL	CDS	3355099	3356541	.	+	0	ID=cds-CCP45802.1;Parent=gene-Rv2997;Dbxref=EnsemblGenomes-Gn:Rv2997,EnsemblGenomes-Tr:CCP45802,UniProtKB/TrEMBL:I6YAU3,NCBI_GP:CCP45802.1;Name=CCP45802.1;Note=Rv2997%2C (MTV012.11)%2C len: 480 aa. Possible ala-rich dehydrogenase%2C similar to others dehydrogenases and hypothetical proteins e.g. Q9EYI5 putative dehydrogenase from Streptomyces nogalater (472 aa)%2C FASTA scores: opt: 1131%2C E(): 1.7e-61%2C (41.0%25 identity in 471 aa overlap)%3B Q9ZBG4|SC9B5.16 putative dehydrogenase from Streptomyces coelicolor (472 aa)%2C FASTA scores: opt: 1064%2C E(): 2e-57%2C(39.05%25 identity in 471 aa overlap)%3B Q98BS8 probable dehydrogenase from Rhizobium loti (Mesorhizobium loti) (524 aa)%2C FASTA scores: opt: 196%2C E(): 0.00021%2C (25.1%25 identity in 526 aa overlap)%3B etc. Shows strong similarity throughout its length to O06826|MTCY493.22c|Rv1432 hypothetical 50.5 KDA protein from Mycobacterium tuberculosis (473 aa)%2C FASTA scores: opt: 1220%2C E(): 6.1e-67%2C (42.35%25 identity in 465 aa overlap).;gbkey=CDS;locus_tag=Rv2997;product=Possible alanine rich dehydrogenase;protein_id=CCP45802.1;transl_table=11
AL123456.3	EMBL	gene	3356815	3357276	.	+	.	ID=gene-Rv2998;Name=Rv2998;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2998
AL123456.3	EMBL	CDS	3356815	3357276	.	+	0	ID=cds-CCP45803.1;Parent=gene-Rv2998;Dbxref=EnsemblGenomes-Gn:Rv2998,EnsemblGenomes-Tr:CCP45803,GOA:O53245,UniProtKB/TrEMBL:O53245,NCBI_GP:CCP45803.1;Name=CCP45803.1;Note=Rv2998%2C (MTV012.12)%2C len: 153 aa. Hypothetical unknown protein. Note that equivalent to AAK47405 Hypothetical 19.4 kDa protein from Mycobacterium tuberculosis strain CDC1551 (186 aa) but sequence differs in N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv2998;product=Hypothetical protein;protein_id=CCP45803.1;transl_table=11
AL123456.3	EMBL	gene	3357225	3357428	.	-	.	ID=gene-Rv2998A;Name=Rv2998A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv2998A
AL123456.3	EMBL	CDS	3357225	3357428	.	-	0	ID=cds-CCP45804.1;Parent=gene-Rv2998A;Dbxref=EnsemblGenomes-Gn:Rv2998A,EnsemblGenomes-Tr:CCP45804,GOA:Q6MX20,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR009082,UniProtKB/TrEMBL:Q6MX20,NCBI_GP:CCP45804.1;Name=CCP45804.1;Note=Rv2998A%2C len: 67 aa. Probable conserved hypothetical protein%2C (possibly gene fragment)%2C highly similar to central part of two-component sensor proteins e.g. O07777|Rv0601c|MTCY19H5.21 two component sensor (fragment) from Mycobacterium tuberculosis (156 aa)%2C FASTA scores: opt: 212%2C E(): 3.7e-09%2C (58.2%25 identity in 67 aa overlap)%3B Q9L2B6|SC8F4.08 probable two-component sensor kinase from Streptomyces coelicolor (478 aa)%2C FASTA scores: opt: 193%2CE(): 2.6e-07%2C (47.05%25 identity in 68 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv2998A;product=Conserved hypothetical protein;protein_id=CCP45804.1;transl_table=11
AL123456.3	EMBL	gene	3357602	3358567	.	+	.	ID=gene-Rv2999;Name=lppY;gbkey=Gene;gene=lppY;gene_biotype=protein_coding;locus_tag=Rv2999
AL123456.3	EMBL	CDS	3357602	3358567	.	+	0	ID=cds-CCP45805.1;Parent=gene-Rv2999;Dbxref=EnsemblGenomes-Gn:Rv2999,EnsemblGenomes-Tr:CCP45805,GOA:O53246,InterPro:IPR011094,UniProtKB/TrEMBL:O53246,NCBI_GP:CCP45805.1;Name=CCP45805.1;Note=Rv2999%2C (MTV012.13)%2C len: 321 aa. Probable lppY%2Cconserved lipoprotein%2C highly similar to O07774|LPQO|Rv0604|MTCY19H5.18c putative lipoprotein from Mycobacterium tuberculosis (316 aa)%2C FASTA scores: opt: 1153%2C E(): 5e-62%2C (53.2%25 identity in 312 aa overlap)%3B and showing similarity with AAK80743|CAC2799 uncharacterized conserved protein similar to LPPY/LPQO of Mycobacterium tuberculosis from Clostridium acetobutylicum (152 aa)%2CFASTA scores: opt: 165%2C E(): 0.0077%2C (26.08%25 identity in 138 aa overlap)%3B and Q9F2T1|SCD65.01c putative lipoprotein (fragment) from Streptomyces coelicolor (146 aa)%2C FASTA scores: opt: 126%2C E(): 1.6%2C (%25 identity in aa overlap). Equivalent to AAK47407 from Mycobacterium tuberculosis strain CDC1551 (329 aa) but shorter 8 aa. Contains probable N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppY;inference=protein motif:PROSITE:PS00013;locus_tag=Rv2999;product=Probable conserved lipoprotein LppY;protein_id=CCP45805.1;transl_table=11
AL123456.3	EMBL	gene	3358612	3359271	.	+	.	ID=gene-Rv3000;Name=Rv3000;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3000
AL123456.3	EMBL	CDS	3358612	3359271	.	+	0	ID=cds-CCP45806.1;Parent=gene-Rv3000;Dbxref=EnsemblGenomes-Gn:Rv3000,EnsemblGenomes-Tr:CCP45806,GOA:I6X5Z8,InterPro:IPR003439,InterPro:IPR005226,InterPro:IPR027417,UniProtKB/TrEMBL:I6X5Z8,NCBI_GP:CCP45806.1;Name=CCP45806.1;Note=Rv3000%2C (MTV012.14)%2C len: 219 aa. Possible conserved transmembrane protein%2C similar to various membrane proteins e.g. P77307|YBBM_ECOLI|B0491 hypothetical 28.2 KDA protein (potential integral membrane protein) from Escherichia coli strain K12 (259 aa)%2C FASTA scores: opt: 292%2C E(): 3.1e-11%2C(30.25%25 identity in 218 aa overlap)%3B N-terminus of Q9BJF3 putative ABC transporter (fragment) from Sterkiella histriomuscorum (1319 aa)%2C FASTA scores: opt: 274%2C E(): 1.3e-09%2C (39.6%25 identity in 101 aa overlap)%3B Q9C9W0|T23K23.21 putative ABC transporter from Arabidopsis thaliana (Mouse-ear cress) (263 aa)%2C FASTA scores: opt: 258%2C E(): 4.4e-09%2C (30.1%25 identity in 196 aa overlap)%3B P74369|YG47_SYNY3|SLR1647 hypothetical 28.1 KDA protein (potential integral membrane protein) from Synechocystis sp. strain PCC 6803 (259 aa)%2C FASTA scores: opt: 257%2C E(): 5.1e-09%2C (37.75%25 identity in 98 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3000;product=Possible conserved transmembrane protein;protein_id=CCP45806.1;transl_table=11
AL123456.3	EMBL	gene	3359585	3360586	.	-	.	ID=gene-Rv3001c;Name=ilvC;gbkey=Gene;gene=ilvC;gene_biotype=protein_coding;locus_tag=Rv3001c
AL123456.3	EMBL	CDS	3359585	3360586	.	-	0	ID=cds-CCP45807.1;Parent=gene-Rv3001c;Dbxref=EnsemblGenomes-Gn:Rv3001c,EnsemblGenomes-Tr:CCP45807,GOA:P9WKJ7,InterPro:IPR000506,InterPro:IPR008927,InterPro:IPR013023,InterPro:IPR013116,InterPro:IPR013328,NCBI_GP:CCP45807.1;Name=CCP45807.1;Note=Rv3001c%2C (MT3081%2C MTV012.15c)%2C len: 333 aa. Probable ilvC%2C ketol-acid reductoisomerase%2C equivalent or highly similar to others e.g. Q59500|ILVC_MYCAV from Mycobacterium avium (333 aa)%2C FASTA scores: opt: 1977%2C E(): 3.2e-113%2C(87.7%25 identity in 333 aa overlap)%3B O33114|ILVC_MYCLE from Mycobacterium leprae (333 aa)%2C FASTA scores: opt: 1924%2CE(): 5.3e-110%2C (86.5%25 identity in 333 aa overlap)%3B Q9Z565|ILVC_STRCO|SC8D9.26 from Streptomyces coelicolor (332 aa)%2C FASTA scores: opt: 1494%2C E(): 8.3e-84%2C (67.5%25 identity in 326 aa overlap)%3B Q59818|ILVC_STRAW from Streptomyces avermitilis (333 aa) FASTA scores: opt: 1487%2CE(): 2.2e-83%2C (66.8%25 identity in 326 aa overlap)%3B etc. Belongs to the KETOL-acid reductoisomerases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvC;locus_tag=Rv3001c;product=Probable KETOL-acid reductoisomerase IlvC (acetohydroxy-acid isomeroreductase) (alpha-keto-beta-hydroxylacil reductoisomerase);protein_id=CCP45807.1;transl_table=11
AL123456.3	EMBL	gene	3360624	3361130	.	-	.	ID=gene-Rv3002c;Name=ilvN;gbkey=Gene;gene=ilvN;gene_biotype=protein_coding;gene_synonym=ilvH;locus_tag=Rv3002c
AL123456.3	EMBL	CDS	3360624	3361130	.	-	0	ID=cds-CCP45808.1;Parent=gene-Rv3002c;Dbxref=EnsemblGenomes-Gn:Rv3002c,EnsemblGenomes-Tr:CCP45808,GOA:P9WKJ3,InterPro:IPR002912,InterPro:IPR004789,InterPro:IPR019455,NCBI_GP:CCP45808.1;Name=CCP45808.1;Note=Rv3002c%2C (MT3082%2C MTV012.16c)%2C len: 168 aa. Probable ilvN (alternate gene name: ilvH)%2C acetolactate synthase%2Csmall subunit%2C equivalent or highly similar to others e.g. O33113|ILVH_MYCLE|MLCB637.21 from Mycobacterium leprae (169 aa)%2C FASTA scores: opt: 843%2C E(): 5.1e-47%2C (83.5%25 identity in 164 aa overlap)%3B Q59499|ILVH_MYCAV|ILVN from Mycobacterium avium (167 aa)%2C FASTA scores: opt: 798%2C E(): 3.7e-44%2C (81.05%25 identity in 169 aa overlap)%3B Q9Z566|ILVN from Streptomyces coelicolor (174 aa)%2C FASTA scores: opt: 678%2C E(): 1.7e-36%2C (64.8%25 identity in 159 aa overlap)%3B etc. Belongs to the acetolactate synthase small subunit family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvN;locus_tag=Rv3002c;product=Probable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) (AHAS) (ALS);protein_id=CCP45808.1;transl_table=11
AL123456.3	EMBL	gene	3361130	3362986	.	-	.	ID=gene-Rv3003c;Name=ilvB1;gbkey=Gene;gene=ilvB1;gene_biotype=protein_coding;gene_synonym=ilvB;locus_tag=Rv3003c
AL123456.3	EMBL	CDS	3361130	3362986	.	-	0	ID=cds-CCP45809.1;Parent=gene-Rv3003c;Dbxref=EnsemblGenomes-Gn:Rv3003c,EnsemblGenomes-Tr:CCP45809,GOA:P9WG41,InterPro:IPR000399,InterPro:IPR011766,InterPro:IPR012000,InterPro:IPR012001,InterPro:IPR012846,InterPro:IPR029035,InterPro:IPR029061,NCBI_GP:CCP45809.1;Name=CCP45809.1;Note=Rv3003c%2C (MT3083%2C MTV012.17c)%2C len: 618 aa. ilvB1%2Cacetolactate synthase%2C large subunit%2C equivalent or highly similar to others e.g. O33112|ILVB_MYCLE|MLCB637.20|ML1696 from Mycobacterium leprae (625 aa)%2C FASTA scores: opt: 3653%2C E(): 5.4e-208%2C (87.1%25 identity in 627 aa overlap)%3B Q59498|ILVB_MYCAV from Mycobacterium avium (621 aa)%2C FASTA scores: opt: 3473%2C E(): 2.3e-197%2C (84.7%25 identity in 614 aa overlap)%3B P42463|ILVB_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (626 aa)%2C FASTA scores: opt: 2754%2CE(): 5.9e-155%2C (65.8%25 identity in 589 aa overlap)%3B etc. Contains PS00187 Thiamine pyrophosphate enzymes signature. Cofactor: thiamine pyrophosphate%2C and magnesium (by similarity). Note that previously known as ilvB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvB1;inference=protein motif:PROSITE:PS00187;locus_tag=Rv3003c;product=Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase);protein_id=CCP45809.1;transl_table=11
AL123456.3	EMBL	gene	3363348	3363686	.	+	.	ID=gene-Rv3004;Name=cfp6;gbkey=Gene;gene=cfp6;gene_biotype=protein_coding;locus_tag=Rv3004
AL123456.3	EMBL	CDS	3363348	3363686	.	+	0	ID=cds-CCP45810.1;Parent=gene-Rv3004;Dbxref=EnsemblGenomes-Gn:Rv3004,EnsemblGenomes-Tr:CCP45810,GOA:P9WIR1,InterPro:IPR019692,InterPro:IPR020535,NCBI_GP:CCP45810.1;Name=CCP45810.1;Note=Rv3004%2C (MT3084.1%2C MTV012.18)%2C len: 112 aa. Cfp6%2Clow molecular weight protein antigen 6 (CFP-6) (See Bhaskar et al.%2C 2000). Weak homology with Q9RKZ5|SC6D7.02 putative membrane protein from Streptomyces coelicolor (156 aa)%2CFASTA scores: opt: 109%2C E(): 0.78%2C (39.4%25 identity in 122 aa overlap). Caution: the initiator methionine may be further upstream making the sequence a precursor. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cfp6;locus_tag=Rv3004;product=Low molecular weight protein antigen 6 (CFP-6);protein_id=CCP45810.1;transl_table=11
AL123456.3	EMBL	gene	3363693	3364532	.	-	.	ID=gene-Rv3005c;Name=Rv3005c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3005c
AL123456.3	EMBL	CDS	3363693	3364532	.	-	0	ID=cds-CCP45811.1;Parent=gene-Rv3005c;Dbxref=EnsemblGenomes-Gn:Rv3005c,EnsemblGenomes-Tr:CCP45811,InterPro:IPR011637,UniProtKB/TrEMBL:I6YAV3,NCBI_GP:CCP45811.1;Name=CCP45811.1;Note=Rv3005c%2C (MTV012.19c)%2C len: 279 aa. Conserved hypothetical protein%2C equivalent to O33110|MLCB637.18|ML1698 hypothetical 29.5 KDA protein from Mycobacterium leprae (277 aa)%2C FASTA scores: opt: 1245%2CE(): 1.2e-65%2C (70.5%25 identity in 278 aa overlap). Also similar%2C but longer approximately 100 aa in N-terminus%2C to other hypothetical proteins%2C few membrane proteins%2C e.g. Q9RKN9|SCC75A.35 putative membrane protein from Streptomyces coelicolor (180 aa)%2C FASTA scores: opt: 326%2CE(): 3.9e-12%2C (44.2%25 identity in 138 aa overlap)%3B P96694|YDFP|AB001488 hypothetical protein from Bacillus subtilis (129 aa)%2C FASTA scores: opt:273%2C E(): 3.7e-09%2C(33.1%25 identity in 130 aa overlap)%3B Q9KKT1|VCA1019 hypothetical protein from Vibrio cholerae (148 aa)%2C FASTA scores: opt: 258%2C E(): 3.1e-08%2C (34.9%25 identity in 126 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3005c;product=Conserved hypothetical protein;protein_id=CCP45811.1;transl_table=11
AL123456.3	EMBL	gene	3364709	3365830	.	+	.	ID=gene-Rv3006;Name=lppZ;gbkey=Gene;gene=lppZ;gene_biotype=protein_coding;locus_tag=Rv3006
AL123456.3	EMBL	CDS	3364709	3365830	.	+	0	ID=cds-CCP45812.1;Parent=gene-Rv3006;Dbxref=EnsemblGenomes-Gn:Rv3006,EnsemblGenomes-Tr:CCP45812,GOA:I6Y293,InterPro:IPR011041,InterPro:IPR011042,InterPro:IPR012938,UniProtKB/TrEMBL:I6Y293,NCBI_GP:CCP45812.1;Name=CCP45812.1;Note=Rv3006%2C (MTV012.20)%2C len: 373 aa. Probable lppZ%2Cconserved lipoprotein%2C equivalent to O33109|MLCB637.17C|ML1699 putative lipoprotein from M. leprae (372 aa)%2C FASTA scores: opt: 2211%2C E(): 4.3e-100%2C(87.1%25 identity in 373 aa overlap). Shows also similarity (in part) with Q9Z571|SC8D9.20c putative oxidoreductase from Streptomyces coelicolor (447 aa)%2C FASTA scores: opt: 185%2C E(): 0.051%2C (31.6%25 identity in 300 aa overlap)%3B Q9Z9R3|BH2090 glucose dehydrogenase-B from Bacillus halodurans (371 aa)%2C FASTA scores: opt: 206%2C E(): 0.0043%2C(28.3%25 identity in 205 aa overlap)%3B and other glucose dehydrogenases B. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C followed by a proline-rich domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppZ;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3006;product=Probable conserved lipoprotein LppZ;protein_id=CCP45812.1;transl_table=11
AL123456.3	EMBL	gene	3365836	3366450	.	-	.	ID=gene-Rv3007c;Name=Rv3007c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3007c
AL123456.3	EMBL	CDS	3365836	3366450	.	-	0	ID=cds-CCP45813.1;Parent=gene-Rv3007c;Dbxref=EnsemblGenomes-Gn:Rv3007c,EnsemblGenomes-Tr:CCP45813,GOA:O53254,InterPro:IPR002563,InterPro:IPR012349,UniProtKB/TrEMBL:O53254,NCBI_GP:CCP45813.1;Name=CCP45813.1;Note=Rv3007c%2C (MTV012.21c)%2C len: 204 aa. Possible oxidoreductase%2C similar to Q9EWU5|3SC5B7.04c putative oxidoreductase from Streptomyces coelicolor (162 aa)%2C FASTA scores: opt: 376%2C E(): 1.5e-18%2C (41.35%25 identity in 150 aa overlap)%3B Q9K416|SCG22.29c putative flavin-dependent reductase protein from Streptomyces coelicolor (169 aa)%2CFASTA scores: opt: 246%2C E(): 1e-09%2C (34.1%25 identity in 135 aa overlap)%3B and some similarity to coupling proteins of 4-hydroxyphenylacetic hydroxylase/monooxygenase e.g. Q9HWT6|HPAC|PA4092 Pseudomonas aeruginosa (170 aa)%2C FASTA score: opt: 214%3B O68232|HPAC Photorhabdus luminescens (Xenorhabdus luminescens) (172 aa)%2C FASTA score: opt: 198%3B Q9RPU2|HPAC Salmonella dublin (170 aa)%2C FASTA score: opt: 197%3B etc. Equivalent to AAK47416 from Mycobacterium tuberculosis strain CDC1551 (236 aa) but shorter 32 aa. Start chosen by similarity.;gbkey=CDS;locus_tag=Rv3007c;product=Possible oxidoreductase;protein_id=CCP45813.1;transl_table=11
AL123456.3	EMBL	gene	3366644	3367267	.	+	.	ID=gene-Rv3008;Name=Rv3008;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3008
AL123456.3	EMBL	CDS	3366644	3367267	.	+	0	ID=cds-CCP45814.1;Parent=gene-Rv3008;Dbxref=EnsemblGenomes-Gn:Rv3008,EnsemblGenomes-Tr:CCP45814,UniProtKB/TrEMBL:I6YEY1,NCBI_GP:CCP45814.1;Name=CCP45814.1;Note=Rv3008%2C (MTV012.22)%2C len: 207 aa (start uncertain). Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3008;product=Hypothetical protein;protein_id=CCP45814.1;transl_table=11
AL123456.3	EMBL	gene	3367264	3368793	.	-	.	ID=gene-Rv3009c;Name=gatB;gbkey=Gene;gene=gatB;gene_biotype=protein_coding;locus_tag=Rv3009c
AL123456.3	EMBL	CDS	3367264	3368793	.	-	0	ID=cds-CCP45815.1;Parent=gene-Rv3009c;Dbxref=EnsemblGenomes-Gn:Rv3009c,EnsemblGenomes-Tr:CCP45815,GOA:P9WN61,InterPro:IPR003789,InterPro:IPR004413,InterPro:IPR006075,InterPro:IPR017958,InterPro:IPR017959,InterPro:IPR018027,NCBI_GP:CCP45815.1;Name=CCP45815.1;Note=Rv3009c%2C (MT3089%2C MTV012.23c)%2C len: 509 aa. Probable gatB%2C Glu- tRNA-Gln amidotransferase%2C subunit B %2Cequivalent to O33107|GATB_MYCLE|MLCB637_15 glutamyl-tRNA(GLN) amidotransferase from Mycobacterium leprae (509 aa)%2C FASTA scores: opt: 2973%2C E(): 2.9e-173%2C(88.4%25 identity in 509 aa overlap). Also highly similar to other Glu- tRNA-Gln amidotransferases e.g. Q9Z578|GATB|SC8D9.13 from Streptomyces coelicolor (504 aa)%2CFASTA scores: opt: 2264%2C E(): 3.6e-130%2C (66.0%25 identity in 495 aa overlap)%3B P74215|GATB_SYNY3|SLL1435 from Synechocystis sp. strain PCC 6803 (519 aa)%2C FASTA scores: opt: 1289%2C E(): 6.7e-71%2C (42.0%25 identity in 485 aa overlap)%3B Q9X100|GATB_THEMA|TM1273 glutamyl-tRNA(GLN) amidotransferase from Thermotoga maritima (482 aa)%2C FASTA scores: opt: 1165%2C E(): 2.2e-63%2C (40.05%25 identity in 487 aa overlap)%3B etc. For more information about function%2C see citation below. Similar to many members of the pet112 family. Belongs to the GatB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gatB;inference=protein motif:PROSITE:PS00041;locus_tag=Rv3009c;product=Probable glutamyl-tRNA(GLN) amidotransferase (subunit B) GatB (Glu-ADT subunit B);protein_id=CCP45815.1;transl_table=11
AL123456.3	EMBL	gene	3368823	3369854	.	-	.	ID=gene-Rv3010c;Name=pfkA;gbkey=Gene;gene=pfkA;gene_biotype=protein_coding;locus_tag=Rv3010c
AL123456.3	EMBL	CDS	3368823	3369854	.	-	0	ID=cds-CCP45816.1;Parent=gene-Rv3010c;Dbxref=EnsemblGenomes-Gn:Rv3010c,EnsemblGenomes-Tr:CCP45816,GOA:P9WID7,InterPro:IPR000023,InterPro:IPR012003,InterPro:IPR012829,InterPro:IPR015912,InterPro:IPR022953,NCBI_GP:CCP45816.1;Name=CCP45816.1;Note=Rv3010c%2C (MTV012.24c)%2C len: 343 aa. Probable pfkA%2Cphosphofructokinase%2C equivalent to O33106|K6PF_MYCLE|MLCB637.14 6-phosphofructokinase from Mycobacterium leprae (343 aa)%2C FASTA scores: opt: 2099%2CE(): 4.1e-122%2C (90.4%25 identity in 343 aa overlap). Also highly similar to others e.g. Q9FC99|K6P3_STRCO from Streptomyces coelicolor (341 aa)%2C FASTA scores: opt: 1329%2CE(): 1.1e-74%2C (58.9%25 identity in 338 aa overlap)%3B Q9L1L8|K6P2_STRCO|PFKA2|PFK2|SC6A11.02 6-phosphofructokinase 2 from Streptomyces coelicolor (341 aa)%2C FASTA scores: opt: 1303%2C E(): 4.5e-73%2C (56.7%25 identity in 342 aa overlap)%3B Q9KH71|PFP PPI-dependent phosphofructokinase from Dictyoglomus thermophilum (346 aa)%2C FASTA scores: opt: 893%2C E(): 8.4e-48%2C (41.85%25 identity in 344 aa overlap)%3B etc. Contains PS00433 Phosphofructokinase signature. Belongs to the phosphofructokinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pfkA;inference=protein motif:PROSITE:PS00433;locus_tag=Rv3010c;product=Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase);protein_id=CCP45816.1;transl_table=11
AL123456.3	EMBL	gene	3369950	3371434	.	-	.	ID=gene-Rv3011c;Name=gatA;gbkey=Gene;gene=gatA;gene_biotype=protein_coding;locus_tag=Rv3011c
AL123456.3	EMBL	CDS	3369950	3371434	.	-	0	ID=cds-CCP45817.1;Parent=gene-Rv3011c;Dbxref=EnsemblGenomes-Gn:Rv3011c,EnsemblGenomes-Tr:CCP45817,GOA:P9WQA1,InterPro:IPR000120,InterPro:IPR004412,InterPro:IPR020556,InterPro:IPR023631,NCBI_GP:CCP45817.1;Name=CCP45817.1;Note=Rv3011c%2C (MT3091%2C MTV012.25c)%2C len: 494 aa. Probable gatA%2C Glu-tRNA-Gln amidotransferase%2C subunit A %2C equivalent to O33105|GATA|ML1702|MLCB637.13 glutamyl-tRNA(GLN) amidotransferase from Mycobacterium leprae (497 aa)%2C FASTA scores: opt: 2839%2C E(): 3.5e-161%2C (88.8%25 identity in 492 aa overlap). Also highly similar to other Glu-tRNA-Gln amidotransferases e.g. Q9Z580|GATA_STRCO from Streptomyces coelicolor (497 aa)%2C FASTA scores: opt: 2231%2C E(): 4.5e-125%2C (70.3%25 identity in 486 aa overlap)%3B P73558|GATA_SYNY3|SLR0877 from Synechocystis sp. strain PCC 6803 (483 aa)%2C FASTA scores: opt: 1593%2C E(): 3.3e-87%2C(55.85%25 identity in 487 aa overlap)%3B O06491|GATA_BACSU glutamyl-tRNA(GLN) amidotransferase from Bacillus subtilis (485 aa)%2C FASTA scores: opt: 1389%2C E(): 4.3e-75%2C (51.7%25 identity in 468 aa overlap)%3B etc. For more information about function%2C see citation below. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the amidase family. Nucleotide position 3370177 in the genome sequence has been corrected%2C T:G resulting in M420L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gatA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3011c;product=Probable glutamyl-tRNA(GLN) amidotransferase (subunit A) GatA (Glu-ADT subunit A);protein_id=CCP45817.1;transl_table=11
AL123456.3	EMBL	gene	3371431	3371730	.	-	.	ID=gene-Rv3012c;Name=gatC;gbkey=Gene;gene=gatC;gene_biotype=protein_coding;locus_tag=Rv3012c
AL123456.3	EMBL	CDS	3371431	3371730	.	-	0	ID=cds-CCP45818.1;Parent=gene-Rv3012c;Dbxref=EnsemblGenomes-Gn:Rv3012c,EnsemblGenomes-Tr:CCP45818,GOA:P9WN59,InterPro:IPR003837,NCBI_GP:CCP45818.1;Name=CCP45818.1;Note=Rv3012c%2C (MT3092%2C MTV012.26c)%2C len: 99 aa. Probable gatC%2C Glu-tRNA-Gln amidotransferase%2C subunit C%2C equivalent to O33104|GATC_MYCLE|MLCB637.12 glutamyl-tRNA(GLN) amidotransferase from Mycobacterium leprae (99 aa)%2C FASTA scores: opt: 483%2C E(): 3.1e-25%2C (74.75%25 identity in 99 aa overlap). Also highly similar to other Glu-tRNA-Gln amidotransferases e.g. Q9Z581|GATC_STRCO|SC8D9.10 from Streptomyces coelicolor (98 aa)%2C FASTA scores: opt: 298%2CE(): 4e-13%2C (53.7%25 identity in 95 aa overlap)%3B O06492|GATC_BACSU from B. subtilis (96 aa)%2C FASTA scores: opt: 222%2C E(): 3.7e-08%2C (43.15%25 identity in 95 aa overlap)%3B Q9KF29|BH0665 from Bacillus halodurans (96 aa)%2C FASTA scores: opt: 211%2C E(): 1.9e-07%2C (41.05%25 identity in 95 aa overlap)%3B etc. For more information about function%2C see citation below. Belongs to the GatC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gatC;locus_tag=Rv3012c;product=Probable glutamyl-tRNA(GLN) amidotransferase (subunit C) GatC (Glu-ADT subunit C);protein_id=CCP45818.1;transl_table=11
AL123456.3	EMBL	gene	3371815	3372471	.	+	.	ID=gene-Rv3013;Name=Rv3013;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3013
AL123456.3	EMBL	CDS	3371815	3372471	.	+	0	ID=cds-CCP45819.1;Parent=gene-Rv3013;Dbxref=EnsemblGenomes-Gn:Rv3013,EnsemblGenomes-Tr:CCP45819,GOA:O53260,InterPro:IPR002912,UniProtKB/TrEMBL:O53260,NCBI_GP:CCP45819.1;Name=CCP45819.1;Note=Rv3013%2C (MTV012.27)%2C len: 218 aa. Conserved protein%2Cequivalent to O33103|MLCB637_11c hypothetical 24.4 KDA protein from Mycobacterium leprae (230 aa)%2C FASTA scores: opt: 1188%2C E(): 2.6e-67%2C (83.95%25 identity in 218 aa overlap). Equivalent to AAK47422 from Mycobacterium tuberculosis strain CDC1551 (240 aa) but shorter 22 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3013;product=Conserved protein;protein_id=CCP45819.1;transl_table=11
AL123456.3	EMBL	gene	3372545	3374620	.	-	.	ID=gene-Rv3014c;Name=ligA;gbkey=Gene;gene=ligA;gene_biotype=protein_coding;gene_synonym=lig;locus_tag=Rv3014c
AL123456.3	EMBL	CDS	3372545	3374620	.	-	0	ID=cds-CCP45820.1;Parent=gene-Rv3014c;Dbxref=EnsemblGenomes-Gn:Rv3014c,EnsemblGenomes-Tr:CCP45820,GOA:P9WNV1,InterPro:IPR001357,InterPro:IPR001679,InterPro:IPR003583,InterPro:IPR004149,InterPro:IPR004150,InterPro:IPR010994,InterPro:IPR012340,InterPro:IPR013839,InterPro:IPR013840,InterPro:IPR018239,PDB:1ZAU,PDB:3SGI,NCBI_GP:CCP45820.1;Name=CCP45820.1;Note=Rv3014c%2C (MT3094%2C MTV012.28c)%2C len: 691 aa. ligA (alternate gene name: lig)%2C DNA ligase NAD-dependent (see citation below)%2C equivalent to O33102|DNLJ_MYCLE|LIGA|LIG|ML1705|MLCB637.10 DNA ligase from Mycobacterium leprae (694 aa)%2C FASTA scores: opt: 3844%2C E(): 0%2C (84.7%25 identity in 687 aa overlap). Also highly similar to many prokaryotic and eukaryotic ligases e.g. Q9Z585|LIGA|SC8D9.06 from Streptomyces coelicolor (735 aa)%2C FASTA scores: opt: 2002%2C E(): 4e-113%2C (59.4%25 identity in 714 aa overlap)%3B P49421|DNLJ_RHOMR|LIGA|LIG from Rhodothermus marinus (712 aa)%2C FASTA scores: opt: 1835%2CE(): 4.6e-103%2C (45.55%25 identity in 685 aa overlap)%3B P15042|DNLJ_ECOLI|LIGA|LIG|DNAL|PDEC|lop|B2411 from Escherichia coli strain K12 (671 aa)%2C FASTA scores: opt: 1696%2C E(): 1.1e-94%2C (43.8%25 identity in 680 aa overlap)%3B etc. Belongs to the NAD-dependent DNA ligase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ligA;locus_tag=Rv3014c;product=DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]);protein_id=CCP45820.1;transl_table=11
AL123456.3	EMBL	gene	3374651	3375664	.	-	.	ID=gene-Rv3015c;Name=Rv3015c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3015c
AL123456.3	EMBL	CDS	3374651	3375664	.	-	0	ID=cds-CCP45821.1;Parent=gene-Rv3015c;Dbxref=EnsemblGenomes-Gn:Rv3015c,EnsemblGenomes-Tr:CCP45821,GOA:I6YAW3,InterPro:IPR002629,UniProtKB/TrEMBL:I6YAW3,NCBI_GP:CCP45821.1;Name=CCP45821.1;Note=Rv3015c%2C (MTV012.29c)%2C len: 337 aa. Conserved hypothetical protein%2C equivalent to Q9CBR6|ML1706 hypothetical protein from Mycobacterium leprae (337 aa)%2CFASTA scores: opt: 1703%2C E(): 3.1e-92%2C (78.05%25 identity in 337 aa overlap)%3B and (but longer 47 aa) O33101|MLCB637.09 hypothetical 30.0 KDA protein from Mycobacterium leprae (290 aa)%2C FASTA scores: opt: 1564%2C E(): 2.4e-78%2C (78.6%25 identity in 290 aa overlap). Also similar to Q9Z586|SC8D9.05 hypothetical 35.0 KDA protein from Streptomyces coelicolor (331 aa)%2C FASTA scores: opt: 774%2CE(): 4.7e-38%2C (43.4%25 identity in 334 aa overlap)%3B and showing similarity with other proteins e.g. Q39586|METE_CHLRE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase from Chlamydomonas reinhardtii (814 aa)%2CFASTA scores: opt: 162%2C E(): 0.048%2C (27.05%25 identity in 355 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3015c;product=Conserved hypothetical protein;protein_id=CCP45821.1;transl_table=11
AL123456.3	EMBL	gene	3375758	3376387	.	+	.	ID=gene-Rv3016;Name=lpqA;gbkey=Gene;gene=lpqA;gene_biotype=protein_coding;locus_tag=Rv3016
AL123456.3	EMBL	CDS	3375758	3376387	.	+	0	ID=cds-CCP45822.1;Parent=gene-Rv3016;Dbxref=EnsemblGenomes-Gn:Rv3016,EnsemblGenomes-Tr:CCP45822,InterPro:IPR026954,UniProtKB/TrEMBL:I6Y2A3,NCBI_GP:CCP45822.1;Name=CCP45822.1;Note=Rv3016%2C (MTV012.30)%2C len: 209 aa. Probable lpqA%2Clipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqA;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3016;product=Probable lipoprotein LpqA;protein_id=CCP45822.1;transl_table=11
AL123456.3	EMBL	gene	3376490	3376852	.	-	.	ID=gene-Rv3017c;Name=esxQ;gbkey=Gene;gene=esxQ;gene_biotype=protein_coding;gene_synonym=ES6_8,TB12.9;locus_tag=Rv3017c
AL123456.3	EMBL	CDS	3376490	3376852	.	-	0	ID=cds-CCP45823.1;Parent=gene-Rv3017c;Dbxref=EnsemblGenomes-Gn:Rv3017c,EnsemblGenomes-Tr:CCP45823,InterPro:IPR010310,NCBI_GP:CCP45823.1;Name=CCP45823.1;Note=Rv3017c%2C (MT3097%2C MTV012.31c)%2C len: 120 aa. EsxQ%2CESAT-6 like protein (see citation below)%2C possibly secreted protein%2C very similar to AAK47433|MT3104 putative secreted ESAT-6 like protein 9 from Mycobacterium tuberculosis strain CDC1551 (96 aa)%2C FASTA scores: opt: 315%2C E(): 1.2e-14%2C (65.7%25 identity in 70 aa overlap)%3B Rv3019c|O53266|MTV012.33c putative secreted ESAT-6 like protein 9 from Mycobacterium tuberculosis (96 aa)%2C FASTA scores: opt: 315%2C E(): 1.2e-14%2C (65.7%25 identity in 70 aa overlap) and Rv0288|O53693|CFP7|MT0301|MTV035.16 10 KDA antigen CFP7 (low molecular weight protein antigen 7) (CFP-7) from Mycobacterium tuberculosis (95 aa)%2C FASTA scores: opt: 303%2C E(): 7.4e-14%2C (66.2%25 identity in 68 aa overlap). An alternative start site exists at 3376801. Belongs to the ESAT6 family. Note previously known as TB12.9.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxQ;locus_tag=Rv3017c;product=ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8);protein_id=CCP45823.1;transl_table=11
AL123456.3	EMBL	gene	3376939	3378243	.	-	.	ID=gene-Rv3018c;Name=PPE46;gbkey=Gene;gene=PPE46;gene_biotype=protein_coding;locus_tag=Rv3018c
AL123456.3	EMBL	CDS	3376939	3378243	.	-	0	ID=cds-CCP45824.1;Parent=gene-Rv3018c;Dbxref=EnsemblGenomes-Gn:Rv3018c,EnsemblGenomes-Tr:CCP45824,GOA:P9WHY9,InterPro:IPR000030,NCBI_GP:CCP45824.1;Name=CCP45824.1;Note=Rv3018c%2C (MTV012.32c)%2C len: 434 aa. PPE46%2C Member of PPE family but lacks Gly%2C Ala rich repeats at C-terminal domain%2C closest to MTCY261.19. See citation below. Also very similar to following ORF MTV012.35c. Nearly identical in parts to Mycobacterium tuberculosis protein erroneously described as dihydrofolate reductase (X59271|MTFOLA_1) P31500|DYR_MYCTU (214 aa)%2C FASTA scores: opt: 972%2C E(): 4.4e-42%2C (80.0%25 identity in 195 aa overlap)%3B and Z97559|MTCY261_19 from Mycobacterium tuberculosis cosmid (473 aa)%2C FASTA scores: opt: 806%2C E(): 0%3B (38.8%25 identity in 479 aa overlap)%3B and O53268|MTV012.35c from Mycobacterium tuberculosis (358 aa)%2C FASTA scores: opt: 1714%2C E(): 3.3e-79%2C (78.3%25 identity in 355 aa overlap).;gbkey=CDS;gene=PPE46;locus_tag=Rv3018c;product=PPE family protein PPE46;protein_id=CCP45824.1;transl_table=11
AL123456.3	EMBL	gene	3378329	3378415	.	-	.	ID=gene-Rv3018A;Name=PE27A;gbkey=Gene;gene=PE27A;gene_biotype=protein_coding;locus_tag=Rv3018A
AL123456.3	EMBL	CDS	3378329	3378415	.	-	0	ID=cds-CCP45825.1;Parent=gene-Rv3018A;Dbxref=EnsemblGenomes-Gn:Rv3018A,EnsemblGenomes-Tr:CCP45825,UniProtKB/TrEMBL:Q6MX19,NCBI_GP:CCP45825.1;Name=CCP45825.1;Note=Rv3018A%2C len: 28 aa. PE27A%2C Member of Mycobacterium tuberculosis PE family (see Brennan and Delogu%2C 2002)%2C most similar to Rv0285 (102 aa)%2C FASTA scores: opt: 147%2C E(): 3.5e-05%2C (92.85%25 identity in 28 aa overlap)%3B etc.;gbkey=CDS;gene=PE27A;locus_tag=Rv3018A;product=PE family protein PE27A;protein_id=CCP45825.1;transl_table=11
AL123456.3	EMBL	gene	3378711	3379001	.	-	.	ID=gene-Rv3019c;Name=esxR;gbkey=Gene;gene=esxR;gene_biotype=protein_coding;gene_synonym=ES6_9,TB10.3;locus_tag=Rv3019c
AL123456.3	EMBL	CDS	3378711	3379001	.	-	0	ID=cds-CCP45826.1;Parent=gene-Rv3019c;Dbxref=EnsemblGenomes-Gn:Rv3019c,EnsemblGenomes-Tr:CCP45826,GOA:P9WNI9,InterPro:IPR010310,PDB:3H6P,NCBI_GP:CCP45826.1;Name=CCP45826.1;Note=Rv3019c%2C (MT3104%2C MTV012.33c)%2C len: 96 aa. EsxR%2Csecreted ESAT-6 like protein (see citations below)%2C most similar to O53693|AAK44525|Rv0288|CFP7|MT0301|MTV035.16 10 KDA antigen CFP7 (low molecular weight protein antigen 7) (CFP-7) from Mycobacterium tuberculosis (95 aa)%2C FASTA scores: opt: 566%2C E(): 5.1e-31%2C (84.3%25 identity in 95 aa overlap). Also similar to Q9CD33|ML2531 possible cell surface protein from Mycobacterium leprae (96 aa)%2C FASTA scores: opt: 472%2C E(): 8.3e-25%2C (66.6%25 identity in 96 aa overlap)%3B O53264|Rv3017c|MTV012.31c putative secreted antigen from Mycobacterium tuberculosis (120 aa)%2C FASTA scores: opt: 321%2C E(): 9.6e-15%2C (67.15%25 identity in 70 aa overlap)%3B Q57165|AAK48357|O84901|X79562|ESAT6|Rv3875|MT3989|MTV027.1 0esat6 gene from Mycobacterium tuberculosis strain Erdman (94 aa)%2C FASTA scores: opt: 131%2C E(): 0.028%2C (26.1%25 identity in 88 aa overlap). Belongs to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxR;locus_tag=Rv3019c;product=Secreted ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9);protein_id=CCP45826.1;transl_table=11
AL123456.3	EMBL	gene	3379036	3379329	.	-	.	ID=gene-Rv3020c;Name=esxS;gbkey=Gene;gene=esxS;gene_biotype=protein_coding;gene_synonym=PE28;locus_tag=Rv3020c
AL123456.3	EMBL	CDS	3379036	3379329	.	-	0	ID=cds-CCP45827.1;Parent=gene-Rv3020c;Dbxref=EnsemblGenomes-Gn:Rv3020c,EnsemblGenomes-Tr:CCP45827,GOA:Q6MX18,InterPro:IPR010310,PDB:3H6P,UniProtKB/TrEMBL:Q6MX18,NCBI_GP:CCP45827.1;Name=CCP45827.1;Note=Rv3020c%2C (MTV012.34c)%2C len: 97 aa. EsxS%2C ESAT-6 like protein. PE-family related protein%3B distant member of the Mycobacterium tuberculosis PE family%2C similar to AAK44524|MT0300 PE family protein from M. tuberculosis strain CDC1551 (97 aa)%2C FASTA scores: opt: 564%2C E(): 5.9e-30%2C (91.75%25 identity in 97 aa overlap). Has potential helix-turn-helix motif at positions 14-35. Seems to belong to the ESAT6 family (see Betts et al.%2C 2002). Note that previously known as PE28. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;gbkey=CDS;gene=esxS;locus_tag=Rv3020c;product=ESAT-6 like protein EsxS;protein_id=CCP45827.1;transl_table=11
AL123456.3	EMBL	pseudogene	3379376	3380452	.	-	.	ID=gene-Rv3021c;Name=PPE47;gbkey=Gene;gene=PPE47;gene_biotype=pseudogene;locus_tag=Rv3021c;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	3379376	3380452	.	-	0	ID=cds-Rv3021c;Parent=gene-Rv3021c;Dbxref=InterPro:IPR000030,PSEUDO:CCP45828.1;Note=Rv3021c%2C (MTV012.35c)%2C len: 358 aa. PPE47%2C Member of Mycobacterium tuberculosis PPE family. Should be continuation of upstream ORF MTV012.36c but is frameshifted due to missing base at 36448 in v012. Sequence has been checked but no error apparent. Very similar to neighbouring ORF O53265|MTV012.32c|Rv3018c from Mycobacterium tuberculosis (434 aa)%2C FASTA scores: opt: 1714%2C E(): 6.6e-770%2C (78.3%25 identity in 355 aa overlap) and AAK47430|MT3101 (strongly in the N-terminal part) (310 aa)%2CFASTA scores: opt: 897%2C E(): 4.5e-37%2C (66.95%25 identity in 227 aa overlap).;gbkey=CDS;gene=PPE47;locus_tag=Rv3021c;product=PPE family protein PPE47;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	pseudogene	3380440	3380682	.	-	.	ID=gene-Rv3022c;Name=PPE48;gbkey=Gene;gene=PPE48;gene_biotype=pseudogene;locus_tag=Rv3022c;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	3380440	3380682	.	-	0	ID=cds-Rv3022c;Parent=gene-Rv3022c;Note=Rv3022c%2C (MTV012.36c)%2C len: 81 aa. PPE48%2C Member of M. tuberculosis PPE family with frameshift due to missing bp in codon 82. The ORF continues in downstream MTV012.35c. The sequence has been checked and no errors were detected. Identical to neigbouring ORF O53265|Rv3018c|MTV012.32c (434 aa)%2C FASTA scores: opt: 526%2C E(): 6.2e-26%2C (100.0%25 identity in 81 aa overlap)%3B and O69706|Rv739c|MTV025.087c (77 aa)%2CFASTA scores: opt: 392%2C E(): 3.4e-18%2C (72.7%25 identity in 77 aa overlap).;gbkey=CDS;gene=PPE48;locus_tag=Rv3022c;product=PPE family protein PPE48;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	3380679	3380993	.	-	.	ID=gene-Rv3022A;Name=PE29;gbkey=Gene;gene=PE29;gene_biotype=protein_coding;locus_tag=Rv3022A
AL123456.3	EMBL	CDS	3380679	3380993	.	-	0	ID=cds-CCP45830.1;Parent=gene-Rv3022A;Dbxref=EnsemblGenomes-Gn:Rv3022A,EnsemblGenomes-Tr:CCP45830,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MX17,NCBI_GP:CCP45830.1;Name=CCP45830.1;Note=Rv3022A%2C len: 104 aa. PE29%2C Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu%2C 2002)%2C similar to many others e.g. Rv0285|AL021930_12 from Mycobacterium tuberculosis (102 aa)%2C FASTA scores: opt: 497%2C E(): 3e-21%2C (80.39%25 identity in 102 aa overlap)%3B etc.;gbkey=CDS;gene=PE29;locus_tag=Rv3022A;product=PE family protein PE29;protein_id=CCP45830.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3381351	3382674	.	+	.	ID=id-AL123456.3:3381351..3382674;Note=IS1081-5%2C len: 1324 nt. Insertion sequence IS1081.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1081-5
AL123456.3	EMBL	repeat_region	3381351	3381365	.	+	.	ID=id-AL123456.3:3381351..3381365;Note=15 bp Inverted repeat at left end of IS1081:TCGCGTGATCCTTCG;gbkey=repeat_region
AL123456.3	EMBL	gene	3381375	3382622	.	-	.	ID=gene-Rv3023c;Name=Rv3023c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3023c
AL123456.3	EMBL	CDS	3381375	3382622	.	-	0	ID=cds-CCP45831.1;Parent=gene-Rv3023c;Dbxref=EnsemblGenomes-Gn:Rv3023c,EnsemblGenomes-Tr:CCP45831,GOA:P96354,InterPro:IPR001207,UniProtKB/TrEMBL:P96354,NCBI_GP:CCP45831.1;Name=CCP45831.1;Note=Rv3023c%2C (MTV012.38c)%2C len: 415 aa. Probable IS1081 transposase. Contains PS01007 Transposases%2C Mutator family%2Csignature. Similars to P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c and Rv2512c|MTCY07A7.18c transposases for insertion sequence element IS1081 (415 aa)%2C FASTA scores: opt: 2675%2C E(): 1.8e-162%2C (100.0%25 identity in 415 aa overlap). Belongs to the mutator family of transposase.;gbkey=CDS;inference=protein motif:PROSITE:PS01007;locus_tag=Rv3023c;product=Probable transposase;protein_id=CCP45831.1;transl_table=11
AL123456.3	EMBL	repeat_region	3382660	3382674	.	-	.	ID=id-AL123456.3:3382660..3382674;Note=15 bp Inverted repeat at the right end of IS1081:TCGCGTGATCCTTCG;gbkey=repeat_region
AL123456.3	EMBL	gene	3382785	3383888	.	-	.	ID=gene-Rv3024c;Name=trmU;gbkey=Gene;gene=trmU;gene_biotype=protein_coding;locus_tag=Rv3024c
AL123456.3	EMBL	CDS	3382785	3383888	.	-	0	ID=cds-CCP45832.1;Parent=gene-Rv3024c;Dbxref=EnsemblGenomes-Gn:Rv3024c,EnsemblGenomes-Tr:CCP45832,GOA:P9WJS5,InterPro:IPR004506,InterPro:IPR014729,InterPro:IPR023382,NCBI_GP:CCP45832.1;Name=CCP45832.1;Note=Rv3024c%2C (MT3108%2C MTV012.39c)%2C len: 367 aa. Probable trmU%2C tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase %2Cequivalent to O33099|TRMU_MYCLE|ML1707|MLCB637.07 probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase from Mycobacterium leprae (358 aa)%2C FASTA scores: opt: 2033%2C E(): 5.5e-116%2C (85.45%25 identity in 357 aa overlap). Also highly similar to others e.g. O86583|TRMU_STRCO|SC2A11.22 from Streptomyces coelicolor (376 aa)%2C FASTA scores: opt: 1336%2C E(): 1e-73%2C (56.9%25 identity in 369 aa overlap)%3B BAB49856|MLR2824 from Rhizobium loti (378 aa)%2C FASTA scores: opt: 826%2C E(): 8.3e-43%2C (42.35%25 identity in 359 aa overlap)%3B Q9ZDM1|TRMU_RICPR|RP306 from Rickettsia prowazekii (358 aa)%2C FASTA scores: opt: 800%2C E(): 3e-41%2C (40.1%25 identity in 359 aa overlap)%3B etc. Belongs to the TrmU family.;gbkey=CDS;gene=trmU;locus_tag=Rv3024c;product=Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU;protein_id=CCP45832.1;transl_table=11
AL123456.3	EMBL	gene	3383885	3385066	.	-	.	ID=gene-Rv3025c;Name=iscS;gbkey=Gene;gene=iscS;gene_biotype=protein_coding;gene_synonym=nifS;locus_tag=Rv3025c
AL123456.3	EMBL	CDS	3383885	3385066	.	-	0	ID=cds-CCP45833.1;Parent=gene-Rv3025c;Dbxref=EnsemblGenomes-Gn:Rv3025c,EnsemblGenomes-Tr:CCP45833,GOA:P9WQ71,InterPro:IPR000192,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR016454,PDB:4ISY,NCBI_GP:CCP45833.1;Name=CCP45833.1;Note=Rv3025c%2C (MTV012.40c)%2C len: 393 aa. IscS (alternate gene name: nifS)%2C cysteine desulfurase (NifS-like protein) %2C equivalent to MLCB637.06|O33098 NIFS-like protein from Mycobacterium leprae (396 aa)%2C FASTA scores: opt: 2186%2CE(): 2.7e-122%2C (84.9%25 identity in 391 aa overlap). Also highly similar to many e.g. O86581|SC2A11.20 putative pyridoxal-phosphate-dependent aminotransferase from Streptomyces coelicolor (389 aa)%2C FASTA scores: opt: 1568%2CE(): 1.1e-85%2C (61.7%25 identity in 389 aa overlap)%3B P57795|ISCS|NIFS cysteine desulfurase (NIFS protein homolog) from Methanosarcina thermophila (404 aa)%2C FASTA scores: opt: 1059%2C E(): 1.6e-55%2C (46.2%25 identity in 381 aa overlap)%3B O54055|ISCS_RUMFL|ISCS|NIFS cysteine desulfurase from Ruminococcus flavefaciens (396 aa)%2C FASTA scores: opt: 973%2C E(): 2e-50%2C (43.3%25 identity in 381 aa overlap)%3B P57794|NIFS_ACEDI cysteine desulfurase from Acetobacter diazotrophicus (400 aa)%2C FASTA scores: opt: 958%2C E(): 1.6e-49%2C (41.1%25 identity in 392 aa overlap)%3B etc. Also similar to Rv1464|MTV007.11 from Mycobacterium tuberculosis. Contains PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. Belongs to class-V of pyridoxal-phosphate-dependent aminotransferases%2C NIFS/ISCS subfamily. Cofactor: pyridoxal phosphate (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=iscS;inference=protein motif:PROSITE:PS00595;locus_tag=Rv3025c;product=Cysteine desulfurase IscS (NIFS protein homolog) (nitrogenase metalloclusters biosynthesis protein NIFS);protein_id=CCP45833.1;transl_table=11
AL123456.3	EMBL	gene	3385163	3386077	.	-	.	ID=gene-Rv3026c;Name=Rv3026c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3026c
AL123456.3	EMBL	CDS	3385163	3386077	.	-	0	ID=cds-CCP45834.1;Parent=gene-Rv3026c;Dbxref=EnsemblGenomes-Gn:Rv3026c,EnsemblGenomes-Tr:CCP45834,GOA:I6XFY8,InterPro:IPR002123,UniProtKB/TrEMBL:I6XFY8,NCBI_GP:CCP45834.1;Name=CCP45834.1;Note=Rv3026c%2C (MTV012.41c)%2C len: 304 aa. Conserved hypothetical protein%2C similar to Q9RCZ0|SCM10.08C putative acyltransferase from Streptomyces coelicolor (275 aa)%2CFASTA scores: opt: 393%2C E(): 2.2e-17%2C (41.4%25 identity in 299 aa overlap). Similar in part to other hypothetical proteins and acyltransferases e.g. BAB51968|MLR5533 from Rhizobium loti (266 aa)%2C FASTA scores: opt: 280%2C E(): 2.4e-10%2C (29.45%25 identity in 258 aa overlap)%3B Q9KIH9 putative acyltransferase (putative acyltransferase transmembrane protein) from Rhizobium meliloti (Sinorhizobium meliloti) (292 aa)%2C FASTA scores: opt: 252%2CE(): 1.4e-08%2C (30.5%25 identity in 210 aa overlap)%3B O69114|PLSC putative 1-acyl-SN-glycerol-3-phosphate acyltransferase from Burkholderia pseudomallei (Pseudomonas pseudomallei) (289 aa)%2C FASTA scores: opt: 216%2C E(): 2.4e-06%2C (30.85%25 identity in 269 aa overlap)%3B etc. So may be a member of acyltransferase family protein.;gbkey=CDS;locus_tag=Rv3026c;product=Conserved hypothetical protein;protein_id=CCP45834.1;transl_table=11
AL123456.3	EMBL	gene	3386074	3386919	.	-	.	ID=gene-Rv3027c;Name=Rv3027c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3027c
AL123456.3	EMBL	CDS	3386074	3386919	.	-	0	ID=cds-CCP45835.1;Parent=gene-Rv3027c;Dbxref=EnsemblGenomes-Gn:Rv3027c,EnsemblGenomes-Tr:CCP45835,GOA:I6YEZ8,InterPro:IPR016181,UniProtKB/TrEMBL:I6YEZ8,NCBI_GP:CCP45835.1;Name=CCP45835.1;Note=Rv3027c%2C (MTV012.42c)%2C len: 281 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in N-terminal part. See Vetting et al. 2005. Similar%2C to others e.g. Q9RCY9|SCM10.09c from Streptomyces coelicolor (256 aa)%2C FASTA scores: opt: 498%2CE(): 7.8e-24%2C (47.7%25 identity in 237 aa overlap)%3B BAB50158|MLR3216 from Rhizobium loti (291 aa)%2C FASTA scores: opt: 359%2C E(): 3.7e-15%2C (33.35%25 identity in 246 aa overlap)%3B etc. Start changed since first submission%2Cextended by 25 aa.;gbkey=CDS;locus_tag=Rv3027c;product=GCN5-related N-acetyltransferase;protein_id=CCP45835.1;transl_table=11
AL123456.3	EMBL	gene	3387075	3388031	.	-	.	ID=gene-Rv3028c;Name=fixB;gbkey=Gene;gene=fixB;gene_biotype=protein_coding;gene_synonym=etfA;locus_tag=Rv3028c
AL123456.3	EMBL	CDS	3387075	3388031	.	-	0	ID=cds-CCP45836.1;Parent=gene-Rv3028c;Dbxref=EnsemblGenomes-Gn:Rv3028c,EnsemblGenomes-Tr:CCP45836,GOA:P9WNG9,InterPro:IPR001308,InterPro:IPR014729,InterPro:IPR014730,InterPro:IPR014731,InterPro:IPR018206,InterPro:IPR029035,NCBI_GP:CCP45836.1;Name=CCP45836.1;Note=Rv3028c%2C (MTV012.43c)%2C len: 318 aa. Probable fixB (alternate gene name: etfA)%2C electron transfer flavoprotein (alpha subunit) for various dehydrogenases. Equivalent to O33096|ETFA_MYCLE|FIXB|ML1711|MLCB637.04 electron transfer flavoprotein from Mycobacterium leprae (318 aa)%2C FASTA scores: opt: 1788%2C E(): 1.1e-87%2C (89.3%25 identity in 318 aa overlap). Also highly similar to many e.g. Q9K418|SCG22.27c from Streptomyces coelicolor (320 aa)%2C FASTA scores: opt: 1161%2C E(): 1.6e-54%2C (59.45%25 identity in 323 aa overlap)%3B AAK08137|etfa from Rhodobacter sphaeroides (308 aa)%2C FASTA scores: opt: 792%2C E(): 5.1e-35%2C (45.95%25 identity in 309 aa overlap)%3B P38974|ETFA_PARDE electron transfer flavoprotein from Paracoccus denitrificans (307 aa)%2C FASTA scores: opt: 789%2C E(): 7.4e-35%2C (45.95%25 identity in 309 aa overlap)%3B etc. Belongs to the Etf alpha-subunit / FixB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fixB;locus_tag=Rv3028c;product=Probable electron transfer flavoprotein (alpha-subunit) FixB (alpha-ETF) (electron transfer flavoprotein large subunit) (ETFLS);protein_id=CCP45836.1;transl_table=11
AL123456.3	EMBL	gene	3388070	3388870	.	-	.	ID=gene-Rv3029c;Name=fixA;gbkey=Gene;gene=fixA;gene_biotype=protein_coding;gene_synonym=etfB;locus_tag=Rv3029c
AL123456.3	EMBL	CDS	3388070	3388870	.	-	0	ID=cds-CCP45837.1;Parent=gene-Rv3029c;Dbxref=EnsemblGenomes-Gn:Rv3029c,EnsemblGenomes-Tr:CCP45837,GOA:P9WNG7,InterPro:IPR000049,InterPro:IPR012255,InterPro:IPR014729,InterPro:IPR014730,NCBI_GP:CCP45837.1;Name=CCP45837.1;Note=Rv3029c%2C (MTV012.44c)%2C len: 266 aa. Probable fixA (alternate gene name: etfB)%2C electron transfer flavoprotein (beta-subunit). Equivalent of O33095|ETFB_MYCLE|FixA|MLCB637.03 electron transfer flavoprotein from Mycobacterium leprae (266 aa)%2C FASTA scores: opt: 1603%2C E(): 7.6e-87%2C (95.1%25 identity in 266 aa overlap). Also highly similar to others e.g. Q9K417|SCG22.28c from Streptomyces coelicolor (262 aa)%2CFASTA scores: opt: 860%2C E(): 2.3e-43%2C (52.4%25 identity in 263 aa overlap)%3B O85691|ETFB_MEGEL from Megasphaera elsdenii (270 aa)%2C FASTA scores: opt: 548%2C E(): 4.2e-25%2C(35.15%25 identity in 273 aa overlap)%3B etc. Also highly similar in particular to Q9KHD0|NONH flavoprotein reductase from Streptomyces griseus subsp. griseus (this one is required for macrotetrolide biosynthesis in Streptomyces griseus) (261 aa)%2C FASTA scores: opt: 867%2C E(): 8.8e-44%2C(54.0%25 identity in 263 aa overlap). Belongs to the Etf beta-subunit / FixA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fixA;locus_tag=Rv3029c;product=Probable electron transfer flavoprotein (beta-subunit) FixA (beta-ETF) (electron transfer flavoprotein small subunit) (ETFSS);protein_id=CCP45837.1;transl_table=11
AL123456.3	EMBL	gene	3389101	3389925	.	+	.	ID=gene-Rv3030;Name=Rv3030;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3030
AL123456.3	EMBL	CDS	3389101	3389925	.	+	0	ID=cds-CCP45838.1;Parent=gene-Rv3030;Dbxref=EnsemblGenomes-Gn:Rv3030,EnsemblGenomes-Tr:CCP45838,GOA:P9WJZ1,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP45838.1;Name=CCP45838.1;Note=Rv3030%2C (MTV012.45)%2C len: 274 aa. Conserved protein%2Cequivalent to O33094|MLCB637.02c|ML1713 hypothetical 30.8 KDa protein from Mycobacterium leprae (280 aa)%2C FASTA scores: opt: 1388%2C E(): 5.5e-83%2C (78.2%25 identity in 280 aa overlap). N-terminus has similarity to hypothetical proteins from a number of organisms and to Q54303|EMBL:X86780|RAPM methyltransferase from Streptomyces hygroscopicus (317 aa)%2C FASTA scores: opt: 191%2C E(): 3.6e-05%2C (35.65%25 identity in 101 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3030;product=Conserved protein;protein_id=CCP45838.1;transl_table=11
AL123456.3	EMBL	gene	3389922	3391502	.	+	.	ID=gene-Rv3031;Name=Rv3031;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3031
AL123456.3	EMBL	CDS	3389922	3391502	.	+	0	ID=cds-CCP45839.1;Parent=gene-Rv3031;Dbxref=EnsemblGenomes-Gn:Rv3031,EnsemblGenomes-Tr:CCP45839,GOA:P9WQ27,InterPro:IPR004300,InterPro:IPR011330,InterPro:IPR015293,InterPro:IPR027291,InterPro:IPR028995,NCBI_GP:CCP45839.1;Name=CCP45839.1;Note=Rv3031%2C (MTV012.46)%2C len: 526 aa. Conserved protein%2Cequivalent to Q9CBR4|ML1714 hypothetical protein from Mycobacterium leprae (522 aa)%2C FASTA scores: opt: 3167%2CE(): 4.4e-190%2C (86.15%25 identity in 526 aa overlap)%3B and highly similar to truncated O33093|MLCB637.01c hypothetical 37.2 KDA protein (fragment) from Mycobacterium leprae (338 aa)%2C FASTA scores: opt: 2041%2C E(): 5.7e-120%2C (84.8%25 identity in 342 aa overlap). Also some similarity to hypothetical proteins Q9V0M7|PAB1857 from Pyrococcus abyssi (602 aa)%2C FASTA scores: opt: 477%2C E(): 3.5e-22%2C (31.2%25 identity in 556 aa overlap)%3B and Synechocystis P74630|D90916|SLL0735 from Synechocystis sp. strain PCC 6803 (529 aa)%2C FASTA scores: opt: 282%2C E(): 4.7e-10%2C (28.6%25 identity in 560 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3031;product=Conserved protein;protein_id=CCP45839.1;transl_table=11
AL123456.3	EMBL	gene	3391534	3392778	.	+	.	ID=gene-Rv3032;Name=Rv3032;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3032
AL123456.3	EMBL	CDS	3391534	3392778	.	+	0	ID=cds-CCP45840.1;Parent=gene-Rv3032;Dbxref=EnsemblGenomes-Gn:Rv3032,EnsemblGenomes-Tr:CCP45840,GOA:P9WMY9,InterPro:IPR001296,InterPro:IPR028098,NCBI_GP:CCP45840.1;Name=CCP45840.1;Note=Rv3032%2C (MTV012.47)%2C len: 414 aa. Alpha (1->4) glucosyltransferase (See Stadthagen et al.%2C 2007). Equivalent to Q9CBR3|ML1715 putative transferase from Mycobacterium leprae (438 aa)%2C FASTA scores: opt: 2456%2CE(): 7.3e-145%2C (87.9%25 identity in 414 aa overlap). Also similar to hypothetical proteins and various transferases e.g. P73369|SLL1971 hypothetical 46.2 KDA protein from Synechocystis sp. strain PCC 6803 (404 aa)%2C FASTA scores: opt: 584%2C E(): 7.3e-29%2C (34.5%25 identity in 400 aa overlap)%3B Q9Z5B7|SC2G5.06 putative transferase from Streptomyces coelicolor (406 aa)%2C FASTA scores: opt: 509%2C E(): 3.3e-24%2C(35.9%25 identity in 413 aa overlap)%3B Q9UZA1|PAB0827 galactosyltransferase (LPS biosynthesis RFBU related protein) from Pyrococcus abyssi (371 aa)%2C FASTA scores: opt: 381%2C E(): 2.6e-16%2C (26.75%25 identity in 404 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3032;product=Alpha (1->4) glucosyltransferase;protein_id=CCP45840.1;transl_table=11
AL123456.3	EMBL	gene	3392812	3393201	.	+	.	ID=gene-Rv3032A;Name=Rv3032A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3032A
AL123456.3	EMBL	CDS	3392812	3393201	.	+	0	ID=cds-CCP45841.1;Parent=gene-Rv3032A;Dbxref=EnsemblGenomes-Gn:Rv3032A,EnsemblGenomes-Tr:CCP45841,UniProtKB/TrEMBL:I6X630,NCBI_GP:CCP45841.1;Name=CCP45841.1;Note=Rv3032A%2C len: 129 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3032A;product=Conserved protein;protein_id=CCP45841.1;transl_table=11
AL123456.3	EMBL	gene	3393380	3393928	.	+	.	ID=gene-Rv3033;Name=Rv3033;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3033
AL123456.3	EMBL	CDS	3393380	3393928	.	+	0	ID=cds-CCP45842.1;Parent=gene-Rv3033;Dbxref=EnsemblGenomes-Gn:Rv3033,EnsemblGenomes-Tr:CCP45842,InterPro:IPR025637,UniProtKB/TrEMBL:I6YAY5,NCBI_GP:CCP45842.1;Name=CCP45842.1;Note=Rv3033%2C (MTV012.48)%2C len: 182 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3033;product=Unknown protein;protein_id=CCP45842.1;transl_table=11
AL123456.3	EMBL	gene	3394019	3394921	.	-	.	ID=gene-Rv3034c;Name=Rv3034c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3034c
AL123456.3	EMBL	CDS	3394019	3394921	.	-	0	ID=cds-CCP45843.1;Parent=gene-Rv3034c;Dbxref=EnsemblGenomes-Gn:Rv3034c,EnsemblGenomes-Tr:CCP45843,GOA:O53281,InterPro:IPR001451,InterPro:IPR011004,NCBI_GP:CCP45843.1;Name=CCP45843.1;Note=Rv3034c%2C (MTV012.49c)%2C len: 300 aa. Possible transferase (2.-.-.-)%2C equivalent to AAK47449|MT3119 Hexapeptide transferase family protein from M. tuberculosis strain CDC1551 but N-terminus shorter 39 residues (262 aa)%2CFASTA scores: opt: 1773%2C E(): 4.7e-105%2C (100.0%25 identity in 262 aa overlap). Similar to Q9CBR1|ML1719 from Mycobacterium leprae but also shorter in N-terminus (245 aa)%2C FASTA scores: opt: 1549%2C E(): 6.6e-91%2C (90.6%25 identity in 244 aa overlap). Some weakly similarity with other transferases (C-terminal part shows some similarity to acetyltransferase from Methanococcus jannaschii (214 aa)). Alternative start possible at 3395077 but codon usage not as good.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3034c;product=Possible transferase;protein_id=CCP45843.1;transl_table=11
AL123456.3	EMBL	gene	3395379	3396461	.	+	.	ID=gene-Rv3035;Name=Rv3035;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3035
AL123456.3	EMBL	CDS	3395379	3396461	.	+	0	ID=cds-CCP45844.1;Parent=gene-Rv3035;Dbxref=EnsemblGenomes-Gn:Rv3035,EnsemblGenomes-Tr:CCP45844,InterPro:IPR011047,InterPro:IPR018391,InterPro:IPR027295,UniProtKB/TrEMBL:I6XFZ8,NCBI_GP:CCP45844.1;Name=CCP45844.1;Note=Rv3035%2C (MTV012.50)%2C len: 360 aa. Conserved protein%2Cequivalent to Q9CBR0|ML1720 hypothetical protein from Mycobacterium leprae (364 aa)%2C FASTA scores: opt: 1963%2CE(): 1.4e-108%2C (75.8%25 identity in 363 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3035;product=Conserved protein;protein_id=CCP45844.1;transl_table=11
AL123456.3	EMBL	gene	3396458	3397141	.	-	.	ID=gene-Rv3036c;Name=TB22.2;gbkey=Gene;gene=TB22.2;gene_biotype=protein_coding;locus_tag=Rv3036c
AL123456.3	EMBL	CDS	3396458	3397141	.	-	0	ID=cds-CCP45845.1;Parent=gene-Rv3036c;Dbxref=EnsemblGenomes-Gn:Rv3036c,EnsemblGenomes-Tr:CCP45845,InterPro:IPR021729,UniProtKB/TrEMBL:I6YF08,NCBI_GP:CCP45845.1;Name=CCP45845.1;Note=Rv3036c%2C (MTV012.51c)%2C len: 227 aa. Probable TB22.2%2Cconserved secreted protein%2C with putative N-terminal signal peptide%2C highly similar to secreted immunogenic protein MPT64/MPB64 P19996|Rv1980c|MTCY39.39 from Mycobacterium tuberculosis and Mycobacterium bovis (228 aa)%2C FASTA scores: opt: 681%2C E(): 2.5e-35%2C (45.8%25 identity in 227 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB22.2;locus_tag=Rv3036c;product=Probable conserved secreted protein TB22.2;protein_id=CCP45845.1;transl_table=11
AL123456.3	EMBL	gene	3397214	3398290	.	-	.	ID=gene-Rv3037c;Name=Rv3037c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3037c
AL123456.3	EMBL	CDS	3397214	3398290	.	-	0	ID=cds-CCP45846.1;Parent=gene-Rv3037c;Dbxref=EnsemblGenomes-Gn:Rv3037c,EnsemblGenomes-Tr:CCP45846,GOA:P9WJZ3,InterPro:IPR029063,NCBI_GP:CCP45846.1;Name=CCP45846.1;Note=Rv3037c%2C (MTV012.52c)%2C len: 358 aa. Conserved hypothetical protein%2C similar in part to others e.g. O86799|SC6G4.36c from Streptomyces coelicolor (426 aa)%2CFASTA scores: opt: 545%2C E(): 5.5e-27%2C (36.15%25 identity in 354 aa overlap)%3B Q9UZW6|PAB0687 from Pyrococcus abyssi (386 aa)%2C FASTA scores: opt: 262%2C E(): 3.5e-09%2C (31.0%25 identity in 200 aa overlap).;gbkey=CDS;locus_tag=Rv3037c;product=Conserved hypothetical protein;protein_id=CCP45846.1;transl_table=11
AL123456.3	EMBL	gene	3398425	3399408	.	-	.	ID=gene-Rv3038c;Name=Rv3038c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3038c
AL123456.3	EMBL	CDS	3398425	3399408	.	-	0	ID=cds-CCP45847.1;Parent=gene-Rv3038c;Dbxref=EnsemblGenomes-Gn:Rv3038c,EnsemblGenomes-Tr:CCP45847,GOA:I6YAZ1,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:I6YAZ1,NCBI_GP:CCP45847.1;Name=CCP45847.1;Note=Rv3038c%2C (MTV012.53c)%2C len: 327 aa. Conserved protein%2C equivalent to Q9CBQ9|ML1723 hypothetical protein from Mycobacterium leprae (327 aa)%2C FASTA scores: opt: 1843%2C E(): 6.1e-108%2C (80.75%25 identity in 327 aa overlap). Weak similarity with e.g. Q9KZI3|SCG8A.16 putative methyltransferase from Streptomyces coelicolor (199 aa)%2CFASTA scores: opt: 227%2C E(): 3.9e-07%2C (31.95%25 identity in 191 aa overlap) and O52570 methyltransferase from Amycolatopsis mediterranei (272 aa)%2C FASTA scores: opt: 228%2C E(): 4.3e-07%2C (31.7%25 identity in 164 aa overlap). Contains PS00044 Bacterial regulatory proteins%2C lysR family signature but shows no similarity to known LysR family members.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv3038c;product=Conserved protein;protein_id=CCP45847.1;transl_table=11
AL123456.3	EMBL	gene	3399419	3400183	.	-	.	ID=gene-Rv3039c;Name=echA17;gbkey=Gene;gene=echA17;gene_biotype=protein_coding;locus_tag=Rv3039c
AL123456.3	EMBL	CDS	3399419	3400183	.	-	0	ID=cds-CCP45848.1;Parent=gene-Rv3039c;Dbxref=EnsemblGenomes-Gn:Rv3039c,EnsemblGenomes-Tr:CCP45848,GOA:P9WNN3,InterPro:IPR001753,InterPro:IPR029045,NCBI_GP:CCP45848.1;Name=CCP45848.1;Note=Rv3039c%2C (MTV012.54c)%2C len: 254 aa. Probable echA17%2CEnoyl-CoA Hydratase/Isomerase Superfamily member (crotonase). Similar to many e.g. Q9L1E6|SC3D11.16 putative enoyl-CoA hydratase from Streptomyces coelicolor (255 aa)%2CFASTA scores: opt: 625%2C E(): 1.5e-30%2C (45.55%25 identity in 224 aa overlap)%3B O07137||ECH8_MYCLE|ML2402|MLCB1306.05c probable enoyl-CoA hydratase ECHA8 from Mycobacterium leprae (257 aa)%2C FASTA scores: opt: 448%2C E(): 6.4e-20%2C(35.3%25 identity in 235 aa overlap)%2C P97087|CRT crotonase / enoyl-CoA hydratase from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa)%2CFASTA scores: opt: 420%2C E(): 3.1e-18%2C (31.2%25 identity in 234 aa overlap). Also similar to Mycobacterium tuberculosis AAK45356|O53418|Rv1070c|ECHA8|MT1100|MTV017.23c probable enoyl-CoA hydratase ECHA8 (257 aa)%2C FASTA scores: opt: 450%2CE(): 4.9e-20%2C (36.4%25 identity in 226 aa overlap). Belongs to the enoyl-CoA hydratase/isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA17;locus_tag=Rv3039c;product=Probable enoyl-CoA hydratase EchA17 (crotonase) (unsatured acyl-CoA hydratase) (enoyl hydrase);protein_id=CCP45848.1;transl_table=11
AL123456.3	EMBL	gene	3400192	3401058	.	-	.	ID=gene-Rv3040c;Name=Rv3040c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3040c
AL123456.3	EMBL	CDS	3400192	3401058	.	-	0	ID=cds-CCP45849.1;Parent=gene-Rv3040c;Dbxref=EnsemblGenomes-Gn:Rv3040c,EnsemblGenomes-Tr:CCP45849,GOA:O53287,InterPro:IPR000086,InterPro:IPR015797,UniProtKB/TrEMBL:O53287,NCBI_GP:CCP45849.1;Name=CCP45849.1;Note=Rv3040c%2C (MTV012.55c)%2C len: 288 aa. Conserved protein%2C highly similar to Q9XA40|SCH17.07c hypothetical protein from Streptomyces coelicolor (312 aa)%2C FASTA scores: opt: 648%2C E(): 5.2e-34%2C (50.0%25 identity in 260 aa overlap). Also similar to Q9F7R7 predicted mutt superfamily hydrolase from uncultured proteobacterium EBAC31A08 (264 aa)%2C FASTA scores: opt: 295%2C E(): 1.3e-11%2C (27.2%25 identity in 257 aa overlap)%3B AAK24293|CC2322 hypothetical protein from Caulobacter crescentus (254 aa)%2C blast scores: 185 (32%25 identity) and 131 (37%25 identity)%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3040c;product=Conserved protein;protein_id=CCP45849.1;transl_table=11
AL123456.3	EMBL	gene	3401055	3401918	.	-	.	ID=gene-Rv3041c;Name=Rv3041c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3041c
AL123456.3	EMBL	CDS	3401055	3401918	.	-	0	ID=cds-CCP45850.1;Parent=gene-Rv3041c;Dbxref=EnsemblGenomes-Gn:Rv3041c,EnsemblGenomes-Tr:CCP45850,GOA:I6YF11,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR027417,UniProtKB/TrEMBL:I6YF11,NCBI_GP:CCP45850.1;Name=CCP45850.1;Note=Rv3041c%2C (MTV012.56c)%2C len: 287 aa. Probable conserved ATP-binding protein ABC transporter (see citation below)%2C equivalent to Q9CBQ7|ML1726 putative ABC transporter protein ATP-binding protein from Mycobacterium leprae (305 aa)%2C FASTA scores: opt: 1576%2C E(): 8.6e-85%2C(83.4%25 identity in 289 aa overlap). Also similar to other putative ATP-binding proteins ABC transporters e.g. Q9X9Z4|SCI5.06C from Streptomyces coelicolor (265 aa)%2CFASTA scores: opt: 893%2C E(): 4.8e-45%2C (53.3%25 identity in 257 aa overlap)%3B Q9L156|SC5C11.16c from Streptomyces coelicolor (279 aa)%2C FASTA scores: opt: 680%2C E(): 1.3e-32%2C(45.4%25 identity in 271 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3041c;product=Probable conserved ATP-binding protein ABC transporter;protein_id=CCP45850.1;transl_table=11
AL123456.3	EMBL	gene	3401933	3403162	.	-	.	ID=gene-Rv3042c;Name=serB2;gbkey=Gene;gene=serB2;gene_biotype=protein_coding;locus_tag=Rv3042c
AL123456.3	EMBL	CDS	3401933	3403162	.	-	0	ID=cds-CCP45851.1;Parent=gene-Rv3042c;Dbxref=EnsemblGenomes-Gn:Rv3042c,EnsemblGenomes-Tr:CCP45851,GOA:O53289,InterPro:IPR002912,InterPro:IPR004469,InterPro:IPR006383,InterPro:IPR023190,InterPro:IPR023214,UniProtKB/TrEMBL:O53289,NCBI_GP:CCP45851.1;Name=CCP45851.1;Note=Rv3042c%2C (MTV012.57c)%2C len: 409 aa. Probable serB2%2CPhosphoserine phosphatase%2C equivalent to Q9CBQ6|ML1727 putative phosphoserine phosphatase from Mycobacterium leprae (411 aa)%2C FASTA scores: opt: 2173%2C E(): 1.3e-117%2C(86.3%25 identity in 408 aa overlap). Also similar to other e.g. Q9S281|SCI28.02 from Streptomyces coelicolor (410 aa)%2CFASTA scores: opt: 1209%2C E(): 3e-62%2C (51.75%25 identity in 400 aa overlap)%3B Q9HUK|PA4960 from Pseudomonas aeruginosa (429 aa)%2C FASTA scores: opt: 704%2C E(): 3.1e-33%2C (40.95%25 identity in 393 aa overlap)%3B O28142|SERB_ARCTU|AF2138 from Archaeoglobus fulgidus (344 aa)%2C FASTA scores: opt: 671%2CE(): 2e-31%2C (37.25%25 identity in 325 aa overlap)%3B and P06862|SERB_ECOLI (322 aa)%2C FASTA scores: opt: 628%2C E(): 5.7e-29%2C (46.8%25 identity in 235 aa overlap). Belongs to the SerB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=serB2;locus_tag=Rv3042c;product=Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase);protein_id=CCP45851.1;transl_table=11
AL123456.3	EMBL	gene	3403200	3404921	.	-	.	ID=gene-Rv3043c;Name=ctaD;gbkey=Gene;gene=ctaD;gene_biotype=protein_coding;locus_tag=Rv3043c
AL123456.3	EMBL	CDS	3403200	3404921	.	-	0	ID=cds-CCP45852.1;Parent=gene-Rv3043c;Dbxref=EnsemblGenomes-Gn:Rv3043c,EnsemblGenomes-Tr:CCP45852,GOA:P9WP71,InterPro:IPR000883,InterPro:IPR014241,InterPro:IPR023615,InterPro:IPR023616,NCBI_GP:CCP45852.1;Name=CCP45852.1;Note=Rv3043c%2C (MTV012.58c)%2C len: 573 aa. Probable ctaD%2Cintegral membrane cytochrome C oxidase polypeptide I%2Cequivalent to Q9CBQ5|ML1728 from Mycobacterium leprae (574 aa)%2C FASTA scores: opt: 3738%2C E(): 3.8e-216%2C (95.4%25 identity in 566 aa overlap). Also similar to other cytochrome C oxidases polypeptide I e.g. Q9AEL9|CTAD from Corynebacterium glutamicum (Brevibacterium flavum) (584 aa)%2C FASTA scores: opt: 3065%2C E(): 6.8e-176%2C (72.65%25 identity in 567 aa overlap)%3B Q9X813|SC6G10.28c from Streptomyces coelicolor (578 aa)%2C FASTA scores: opt: 2888%2CE(): 2.6e-165%2C (71.7%25 identity in 544 aa overlap)%3B Q9K451|CTAD from Streptomyces coelicolor (573 aa)%2C FASTA scores: opt: 2757%2C E(): 1.8e-157%2C (70.2%25 identity in 537 aa overlap). Contains PS00077 Cytochrome c oxidase subunit I%2Ccopper B binding region signature. Belongs to the heme-copper respiratory oxidase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctaD;inference=protein motif:PROSITE:PS00077;locus_tag=Rv3043c;product=Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1);protein_id=CCP45852.1;transl_table=11
AL123456.3	EMBL	gene	3405136	3406215	.	+	.	ID=gene-Rv3044;Name=fecB;gbkey=Gene;gene=fecB;gene_biotype=protein_coding;locus_tag=Rv3044
AL123456.3	EMBL	CDS	3405136	3406215	.	+	0	ID=cds-CCP45853.1;Parent=gene-Rv3044;Dbxref=EnsemblGenomes-Gn:Rv3044,EnsemblGenomes-Tr:CCP45853,GOA:O53291,InterPro:IPR002491,UniProtKB/TrEMBL:O53291,NCBI_GP:CCP45853.1;Name=CCP45853.1;Note=Rv3044%2C (MTV012.59)%2C len: 359 aa. Probable fecB%2CFeIII dicitrate-binding periplasmic lipoprotein (see citation below)%2C equivalent to Q9CBQ4|FECB|ML1729 putative FEIII-dicitrate transporter lipoprotein from Mycobacterium leprae (364 aa)%2C FASTA scores: opt: 1816%2C E(): 1.1e-96%2C(75.65%25 identity in 357 aa overlap)%3B and Q9LA57|FECB from Mycobacterium avium (364 aa)%2C FASTA scores: opt: 1769%2C E(): 5.1e-94. Similar to many periplasmic FeIII-dicitrate transporters e.g. P72593|FECB|SLR1319 from Synechocystis sp. strain PCC 6803 (315 aa)%2C FASTA scores: opt: 459%2C E(): 3.6e-19%2C (31.35%25 identity in 303 aa overlap)%3B and P72611|FECB|SLR1492 from Synechocystis sp. strain PCC 6803. N-terminus longer (approximately 30 aa) to AAK47459 from Mycobacterium tuberculosis strain CDC1551 (327 aa). Has signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fecB;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3044;product=Probable FEIII-dicitrate-binding periplasmic lipoprotein FecB;protein_id=CCP45853.1;transl_table=11
AL123456.3	EMBL	gene	3406285	3407325	.	+	.	ID=gene-Rv3045;Name=adhC;gbkey=Gene;gene=adhC;gene_biotype=protein_coding;locus_tag=Rv3045
AL123456.3	EMBL	CDS	3406285	3407325	.	+	0	ID=cds-CCP45854.1;Parent=gene-Rv3045;Dbxref=EnsemblGenomes-Gn:Rv3045,EnsemblGenomes-Tr:CCP45854,GOA:P9WQC5,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,NCBI_GP:CCP45854.1;Name=CCP45854.1;Note=Rv3045%2C (MTV012.60)%2C len: 346 aa. Probable adhC%2CNADP-dependent alcohol dehydrogenase%2C equivalent to Q9CBQ3|ADHA|ML1730 alcohol dehydrogenases from Mycobacterium leprae (362 aa)%2C FASTA scores: opt: 1982%2CE(): 1.3e-111%2C (85.85%25 identity in 346 aa overlap)%3B Q9AE96|ADHC from Mycobacterium smegmatis (348 aa)%2C FASTA scores: opt: 1808%2C E(): 3.4e-101%2C (78.95%25 identity in 347 aa overlap)%3B Q9EWF1|SCK13.33c putative dehydrogenase from Streptomyces coelicolor (346 aa)%2C FASTA scores: opt: 1508%2CE(): 3.3e-83%2C (64.45%25 identity in 346 aa overlap)%3B O06007|ADHA from Bacillus subtilis (349 aa)%2C FASTA scores: opt: 1412%2C E(): 1.9e-77%2C (61.8%25 identity in 335 aa overlap)%3B etc. Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Belongs to the zinc-containing alcohol dehydrogenase family. High similarity with other bacterial ADH'S.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adhC;inference=protein motif:PROSITE:PS00059;locus_tag=Rv3045;product=Probable NADP-dependent alcohol dehydrogenase AdhC;protein_id=CCP45854.1;transl_table=11
AL123456.3	EMBL	gene	3407314	3407688	.	-	.	ID=gene-Rv3046c;Name=Rv3046c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3046c
AL123456.3	EMBL	CDS	3407314	3407688	.	-	0	ID=cds-CCP45855.1;Parent=gene-Rv3046c;Dbxref=EnsemblGenomes-Gn:Rv3046c,EnsemblGenomes-Tr:CCP45855,InterPro:IPR021784,UniProtKB/TrEMBL:I6YF16,NCBI_GP:CCP45855.1;Name=CCP45855.1;Note=Rv3046c%2C (MTV012.61c)%2C len: 124 aa. Conserved protein%2C similar to several hypothetical mycobacterial proteins e.g. Q50171|ML2258 U296W hypothetical protein from Mycobacterium leprae (100 aa)%2C FASTA scores: opt: 194%2C E(): 7.6e-06%2C (35.9%25 identity in 103 aa overlap)%3B and O06409|Rv0543c|MTCY25D10.22c from Mycobacterium tuberculosis (100 aa)%2C FASTA scores: opt: 192%2C E(): 1e-05%2C(34.7%25 identity in 98 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3046c;product=Conserved protein;protein_id=CCP45855.1;transl_table=11
AL123456.3	EMBL	gene	3408022	3408306	.	-	.	ID=gene-Rv3047c;Name=Rv3047c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3047c
AL123456.3	EMBL	CDS	3408022	3408306	.	-	0	ID=cds-CCP45856.1;Parent=gene-Rv3047c;Dbxref=EnsemblGenomes-Gn:Rv3047c,EnsemblGenomes-Tr:CCP45856,UniProtKB/TrEMBL:I6X642,NCBI_GP:CCP45856.1;Name=CCP45856.1;Note=Rv3047c%2C (MTV012.62c)%2C len: 94 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3047c;product=Hypothetical protein;protein_id=CCP45856.1;transl_table=11
AL123456.3	EMBL	gene	3408404	3409378	.	-	.	ID=gene-Rv3048c;Name=nrdF2;gbkey=Gene;gene=nrdF2;gene_biotype=protein_coding;gene_synonym=nrdG;locus_tag=Rv3048c
AL123456.3	EMBL	CDS	3408404	3409378	.	-	0	ID=cds-CCP45857.1;Parent=gene-Rv3048c;Dbxref=EnsemblGenomes-Gn:Rv3048c,EnsemblGenomes-Tr:CCP45857,GOA:P9WH71,InterPro:IPR000358,InterPro:IPR009078,InterPro:IPR012348,InterPro:IPR026023,InterPro:IPR026494,PDB:1UZR,NCBI_GP:CCP45857.1;Name=CCP45857.1;Note=Rv3048c%2C (MTV012.63c)%2C len: 324 aa. NrdF2%2Cribonucleoside-diphosphate reductase%2C beta chain (see citation below)%2C equivalent to Q9CBQ2|RIR2_MYCL|NRDF|ML1731 ribonucleoside-diphosphate reductase beta chain from Mycobacterium leprae (325 aa)%2C FASTA scores: opt: 2009%2CE(): 1.3e-123%2C (93.5%25 identity in 324 aa overlap). Also similar to other ribonucleoside-diphosphate reductases e.g. Q9XD62|NRDF from Corynebacterium glutamicum (Brevibacterium flavum) (334 aa)%2C FASTA scores: opt: 1648%2C E(): 4.2e-100%2C(78.35%25 identity in 314 aa overlap)%3B O69274|NRDF from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (329 aa)%2C FASTA scores: opt: 1626%2C E(): 1.1e-98%2C (75.3%25 identity in 320 aa overlap)%3B P37146|NRDF|B2676 from Escherichia coli (319 aa)%2C FASTA scores: opt: 1569%2C E(): 5.7e-95%2C (71.3%25 identity in 317 aa overlap). Contains PS00368 Ribonucleotide reductase small subunit signature. Belongs to the ribonucleoside diphosphate reductase small chain family. Cofactor: binds 2 iron ions (by similarity). Note that previously known as nrdG.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrdF2;inference=protein motif:PROSITE:PS00368;locus_tag=Rv3048c;product=Ribonucleoside-diphosphate reductase (beta chain) NrdF2 (ribonucleotide reductase small subunit) (R2F protein);protein_id=CCP45857.1;transl_table=11
AL123456.3	EMBL	gene	3409509	3411083	.	-	.	ID=gene-Rv3049c;Name=Rv3049c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3049c
AL123456.3	EMBL	CDS	3409509	3411083	.	-	0	ID=cds-CCP45858.1;Parent=gene-Rv3049c;Dbxref=EnsemblGenomes-Gn:Rv3049c,EnsemblGenomes-Tr:CCP45858,GOA:I6Y2E2,UniProtKB/TrEMBL:I6Y2E2,NCBI_GP:CCP45858.1;Name=CCP45858.1;Note=Rv3049c%2C (MTV012.64c)%2C len: 524 aa. Probable monooxygenase%2C similar to several monooxygenases e.g. Q9I3H5|PA1538 probable flavin-containing monooxygenase from Pseudomonas aeruginosa (527 aa)%2C FASTA scores: opt: 1577%2CE(): 3.9e-90%2C (47.3%25 identity in 501 aa overlap)%3B Q9RKB5|SCE87.23c monooxygenase from Streptomyces coelicolor (519 aa)%2C FASTA scores: opt: 1522%2C E(): 9.8e-87%2C (47.4%25 identity in 485 aa overlap)%3B Q9I218|PA2097 probable flavin-binding monooxygenase from Pseudomonas aeruginosa (491 aa)%2C FASTA scores: opt: 1366%2C E(): 4.2e-77%2C (43.75%25 identity in 489 aa overlap)%3B etc. Also similar to Q10532|Rv0892|Y892_MYCTU|MT0916|MTCY31.20 probable monooxygenase from Mycobacterium tuberculosis strain H37Rv (495 aa)%2C FASTA scores: opt: 1147%2C E(): 1.5e-63%2C (38.0%25 identity in 479 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3049c;product=Probable monooxygenase;protein_id=CCP45858.1;transl_table=11
AL123456.3	EMBL	gene	3411217	3411957	.	-	.	ID=gene-Rv3050c;Name=Rv3050c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3050c
AL123456.3	EMBL	CDS	3411217	3411957	.	-	0	ID=cds-CCP45859.1;Parent=gene-Rv3050c;Dbxref=EnsemblGenomes-Gn:Rv3050c,EnsemblGenomes-Tr:CCP45859,GOA:I6XG13,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:I6XG13,NCBI_GP:CCP45859.1;Name=CCP45859.1;Note=Rv3050c%2C (MTV012.65c)%2C len: 246 aa. Probable transcriptional regulatory protein TetR-family%2C equivalent but shorter to Q9CBQ1|ML1733 from Mycobacterium leprae (275 aa)%2C FASTA scores: opt: 1381%2C(E): 2.7e-79%2C (86.25%25 identity in 240 aa overlap)%3B AAK44712|MT0489 from Mycobacterium tuberculosis strain CDC1551 (256 aa)%2C FASTA scores: opt: 328%2C(E): 1.8e-13%2C (30.75%25 identity in 234 aa overlap)%3B etc. Also some similarity to O53757|Rv0472c|MTV038.16c. Alternative starts possible at 68052 or 67923. Has potential helix-turn-helix motif at positons 51-72.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3050c;product=Probable transcriptional regulatory protein (probably AsnC-family);protein_id=CCP45859.1;transl_table=11
AL123456.3	EMBL	gene	3412085	3414166	.	-	.	ID=gene-Rv3051c;Name=nrdE;gbkey=Gene;gene=nrdE;gene_biotype=protein_coding;locus_tag=Rv3051c
AL123456.3	EMBL	CDS	3412085	3414166	.	-	0	ID=cds-CCP45860.1;Parent=gene-Rv3051c;Dbxref=EnsemblGenomes-Gn:Rv3051c,EnsemblGenomes-Tr:CCP45860,GOA:P9WH75,InterPro:IPR000788,InterPro:IPR008926,InterPro:IPR013346,InterPro:IPR013509,InterPro:IPR013554,InterPro:IPR026459,NCBI_GP:CCP45860.1;Name=CCP45860.1;Note=Rv3051c%2C (MTV012.66c)%2C len: 693 aa. NrdE%2Cribonucleotide-diphosphate reductase%2C alpha chain (see citations below)%2C equivalent to Q9CBQ0|NRDE|ML1734 from Mycobacterium leprae (693 aa)%2C FASTA scores: opt: 4259%2CE(): 0%2C (93.2%25 identity in 693 aa overlap). Similar to other Ribonucleoside-diphosphate reductases e.g. Q9XD63|NRDE from Corynebacterium glutamicum (Brevibacterium flavum) (707 aa)%2C FASTA scores: opt: 3683%2CE(): 0%2C (79.35%25 identity in 693 aa overlap)%3B O69273|NRDE from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (720 aa)%2C FASTA scores: opt: 3555%2C E(): 1.7e-214%2C (76.1%25 identity in 694 aa overlap)%3B P39452|NRDE|B2675 from Escherichia coli (713 aa)%2CFASTA scores: opt: 3430%2C E(): 1.1e-206%2C (73.6%25 identity in 693 aa overlap)%3B etc. Equivalent to AAK47468|MT3137 from Mycobacterium tuberculosis strain CDC1551 (725 aa) but shorter in N-terminus. Contains PS00089 Ribonucleotide reductase large subunit signature. Belongs to the ribonucleoside diphosphate reductase large chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrdE;inference=protein motif:PROSITE:PS00089;locus_tag=Rv3051c;product=Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein);protein_id=CCP45860.1;transl_table=11
AL123456.3	EMBL	gene	3414232	3414684	.	-	.	ID=gene-Rv3052c;Name=nrdI;gbkey=Gene;gene=nrdI;gene_biotype=protein_coding;locus_tag=Rv3052c
AL123456.3	EMBL	CDS	3414232	3414684	.	-	0	ID=cds-CCP45861.1;Parent=gene-Rv3052c;Dbxref=EnsemblGenomes-Gn:Rv3052c,EnsemblGenomes-Tr:CCP45861,InterPro:IPR004465,InterPro:IPR020852,InterPro:IPR029039,NCBI_GP:CCP45861.1;Name=CCP45861.1;Note=Rv3052c%2C (MTCY22D7.30)%2C len: 150 aa. Probable nrdI%2Cequivalent to Q9CBP9|NRDI|ML1735 from Mycobacterium leprae (138 aa)%2C FASTA scores: opt: 765%2C E(): 3.8e-44%2C (79.7%25 identity in 138 aa overlap)%2C and similar to many NRDI proteins e.g. Q47415|NRDI_ECOLI|B2674 from Escherichia coli (136 aa)%2C FASTA scores: opt: 574%2C E(): 1.9e-31%2C (62.2%25 identity in 135 aa overlap). Belongs to the NRDI family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nrdI;locus_tag=Rv3052c;product=Probable NrdI protein;protein_id=CCP45861.1;transl_table=11
AL123456.3	EMBL	gene	3414719	3414958	.	-	.	ID=gene-Rv3053c;Name=nrdH;gbkey=Gene;gene=nrdH;gene_biotype=protein_coding;locus_tag=Rv3053c
AL123456.3	EMBL	CDS	3414719	3414958	.	-	0	ID=cds-CCP45862.1;Parent=gene-Rv3053c;Dbxref=EnsemblGenomes-Gn:Rv3053c,EnsemblGenomes-Tr:CCP45862,GOA:I6YB06,InterPro:IPR002109,InterPro:IPR011909,InterPro:IPR012336,PDB:4F2I,PDB:4K8M,UniProtKB/TrEMBL:I6YB06,NCBI_GP:CCP45862.1;Name=CCP45862.1;Note=Rv3053c%2C (MTCY22D7.29)%2C len: 79 aa. Probable nrdH%2Cglutaredoxin-like protein%2C equivalent to Q9CBP8|NRDH|ML1736 from Mycobacterium leprae (80 aa)%2C FASTA scores: opt: 478%2CE(): 2.7e-27%2C (91.15%25 identity in 79 aa overlap)%2C and similar to many glutaredoxin-like proteins e.g. Q9XD65|NRDH from Corynebacterium glutamicum (Brevibacterium flavum) (77 aa)%2C FASTA scores: opt: 382%2C E(): 1.5e-20%2C (72.35%25 identity in 76 aa overlap)%3B and Q56108|NRDH_SALTY from Salmonella typhimurium (81 aa)%2C FASTA scores: opt: 243%2C E(): 9.9e-11%2C(45.85%25 identity in 72 aa overlap). Belongs to the glutaredoxin family.;gbkey=CDS;gene=nrdH;locus_tag=Rv3053c;product=Probable glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH;protein_id=CCP45862.1;transl_table=11
AL123456.3	EMBL	gene	3415435	3415989	.	-	.	ID=gene-Rv3054c;Name=Rv3054c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3054c
AL123456.3	EMBL	CDS	3415435	3415989	.	-	0	ID=cds-CCP45863.1;Parent=gene-Rv3054c;Dbxref=EnsemblGenomes-Gn:Rv3054c,EnsemblGenomes-Tr:CCP45863,GOA:P95105,InterPro:IPR005025,InterPro:IPR029039,UniProtKB/TrEMBL:P95105,NCBI_GP:CCP45863.1;Name=CCP45863.1;Note=Rv3054c%2C (MTCY22D7.28)%2C len: 184 aa. Conserved hypothetical protein%2C similar to Q9RD22|SCM1.21 putative secreted protein from Streptomyces coelicolor (187 aa)%2CFASTA scores: opt: 651%2C E(): 1.5e-33%2C (56.8%25 identity in 175 aa overlap). Also shares similarity with other hypothetical proteins and Chromate reductases e.g. AAK56853|CHRR from Pseudomonas putida (186 aa)%2C FASTA scores: opt: 339%2C E(): 3.3e-14%2C (38.75%25 identity in 160 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599) near C-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00599;locus_tag=Rv3054c;product=Conserved hypothetical protein;protein_id=CCP45863.1;transl_table=11
AL123456.3	EMBL	gene	3416081	3416695	.	+	.	ID=gene-Rv3055;Name=Rv3055;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3055
AL123456.3	EMBL	CDS	3416081	3416695	.	+	0	ID=cds-CCP45864.1;Parent=gene-Rv3055;Dbxref=EnsemblGenomes-Gn:Rv3055,EnsemblGenomes-Tr:CCP45864,GOA:P95103,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:P95103,NCBI_GP:CCP45864.1;Name=CCP45864.1;Note=Rv3055%2C (MTCY22D7.26c)%2C len: 204 aa. Possible transcriptional regulatory protein%2C similar to Q9RD23|SCM1.20c putative TetR-family transcriptional regulator from Streptomyces coelicolor (234 aa)%2C FASTA scores: opt: 471%2C E(): 4.6e-23%2C (44.9%25 identity in 187 aa overlap)%3B and with low similarity to other e.g. Q9ADK8|2SCK31.12 putative TetR-family transcriptional regulator from Streptomyces coelicolor (198 aa)%2C FASTA scores: opt: 208%2C 2.5e-06%2C (32.9%25 identity in 155 aa overlap)%3B Q9ADD9|SCBAC20F6.11c putative TetR-family transcriptional from Streptomyces coelicolor (199 aa)%2CFASTA scores: opt: 182%2C E(): 0.00012%2C (31.0%25 identity in 184 aa overlap). Contains potential helix-turn-helix motif from aa 48 to 69 (+3.42 SD). so may belong to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3055;product=Possible transcriptional regulatory protein (probably TetR-family);protein_id=CCP45864.1;transl_table=11
AL123456.3	EMBL	gene	3416705	3417745	.	+	.	ID=gene-Rv3056;Name=dinP;gbkey=Gene;gene=dinP;gene_biotype=protein_coding;gene_synonym=dinB2;locus_tag=Rv3056
AL123456.3	EMBL	CDS	3416705	3417745	.	+	0	ID=cds-CCP45865.1;Parent=gene-Rv3056;Dbxref=EnsemblGenomes-Gn:Rv3056,EnsemblGenomes-Tr:CCP45865,GOA:P9WNT1,InterPro:IPR001126,InterPro:IPR017961,InterPro:IPR017963,InterPro:IPR022880,NCBI_GP:CCP45865.1;Name=CCP45865.1;Note=Rv3056%2C (MTCY22D7.25c%2C MT3142)%2C len: 346 aa. Possible dinP (alternate gene name: dinB2)%2CDNA-damage-inducible protein (DNA polymerase V) (see citations below)%2C similar to others e.g. AAK45855|MT1589 from Mycobacterium tuberculosis strain CDC1551 (485 aa)%2CFASTA scores: opt: 620%2C E(): 6.1e-32%2C (37.2%25 identity in 344 aa overlap)%3B BAB49140|MLR1877 from Rhizobium loti (Mesorhizobium loti) (415 aa)%2C FASTA scores: opt: 533%2C E(): 1.8e-26%2C (34.35%25 identity in 358 aa overlap)%3B and BAB54888|MLL9709 from Rhizobium loti (Mesorhizobium loti) (361 aa)%2C FASTA scores: opt: 532%2C E(): 1.8e-26%2C (35.35%25 identity in 348 aa overlap). Extensive similarity to proteins induced by DNA damage such as dinP%2C mucB%2C umuC. Belongs to the DNA polymerase type-Y family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dinP;locus_tag=Rv3056;product=Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed));protein_id=CCP45865.1;transl_table=11
AL123456.3	EMBL	gene	3417799	3418662	.	-	.	ID=gene-Rv3057c;Name=Rv3057c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3057c
AL123456.3	EMBL	CDS	3417799	3418662	.	-	0	ID=cds-CCP45866.1;Parent=gene-Rv3057c;Dbxref=EnsemblGenomes-Gn:Rv3057c,EnsemblGenomes-Tr:CCP45866,GOA:I6YB11,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:I6YB11,NCBI_GP:CCP45866.1;Name=CCP45866.1;Note=Rv3057c%2C (MTCY22D7.24)%2C len: 287 aa. Probable oxidoreductase%2C probably short-chain alcohol dehydrogenase/reductase. Equivalent to Q9CBP7|ML1740 possible short chain dehydrogenases/reductase from Mycobacterium leprae (312 aa)%2C FASTA scores: opt: 1563%2CE(): 6e-89%2C (81.8%25 identity in 280 aa overlap). Also similar to many oxidoreductases e.g. Q9ZBX8|SCD78.21c putative oxidoreductase from Streptomyces coelicolor (585 aa)%2C FASTA scores: opt: 541%2C E(): 6.7e-26%2C (37.25%25 identity in 263 aa overlap)%3B AAK47506|MT3170 oxidoreductase%2Cshort-chain dehydrogenase/reductase family from Mycobacterium tuberculosis strain CDC1551 (276 aa)%2C FASTA scores: opt: 521%2C E(): 6.1e-25%2C (36.25%25 identity in 276 aa overlap)%3B AAK45541|MT1283 oxidoreductase%2C short-chain dehydrogenase/reductase family from Mycobacterium tuberculosis strain CDC1551 (276 aa)%2C FASTA scores: opt: 471%2C E(): 7.2e-22%2C (32.4%25 identity in 281 aa overlap). Also similar to O50460|Rv1245c|MTV006.17C dehydrogenase (276 aa). Contains short-chain alcohol dehydrogenase family signature (PS00061). May belong to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv3057c;product=Probable short chain alcohol dehydrogenase/reductase;protein_id=CCP45866.1;transl_table=11
AL123456.3	EMBL	gene	3418726	3419376	.	-	.	ID=gene-Rv3058c;Name=Rv3058c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3058c
AL123456.3	EMBL	CDS	3418726	3419376	.	-	0	ID=cds-CCP45867.1;Parent=gene-Rv3058c;Dbxref=EnsemblGenomes-Gn:Rv3058c,EnsemblGenomes-Tr:CCP45867,GOA:P95100,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:P95100,NCBI_GP:CCP45867.1;Name=CCP45867.1;Note=Rv3058c%2C (MTCY22D7.23)%2C len: 216 aa. Possible transcriptional regulatory protein%2C TetR-family%2C showing reasonable similarity to others e.g. AAK48337|MT3970 from Mycobacterium tuberculosis strain CDC1551 (216 aa)%2C FASTA scores: opt: 261%2C E(): 2.8e-10%2C (31.7%25 identity in 221 aa overlap)%3B Q49962|ML1070|U1756B from Mycobacterium leprae (217 aa)%2C FASTA scores: opt: 234%2C E(): 1.8e-08%2C (27.2%25 identity in 195 aa overlap)%3B Q9CDD3|ML0064 from Mycobacterium leprae (214 aa)%2C FASTA scores: opt: 199%2C E(): 3.6e-06%2C (25.65%25 identity in 195 aa overlap)%3B O66121|CPRS from Streptomyces coelicolor (215 aa)%2C FASTA scores: opt: 183%2C E(): 4.2e-05%2C (26.0%25 identity in 196 aa overlap). Equivalent to AAK47476|MT3144 from Mycobacterium tuberculosis strain CDC1551 (237 aa) but N-terminus shorter 21 residues. Start was predicted by TBParse but alternatives (ATG) are possible. Could belong to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3058c;product=Possible transcriptional regulatory protein (probably TetR-family);protein_id=CCP45867.1;transl_table=11
AL123456.3	EMBL	gene	3419492	3420970	.	+	.	ID=gene-Rv3059;Name=cyp136;gbkey=Gene;gene=cyp136;gene_biotype=protein_coding;locus_tag=Rv3059
AL123456.3	EMBL	CDS	3419492	3420970	.	+	0	ID=cds-CCP45868.1;Parent=gene-Rv3059;Dbxref=EnsemblGenomes-Gn:Rv3059,EnsemblGenomes-Tr:CCP45868,GOA:P9WPM7,InterPro:IPR001128,InterPro:IPR002403,InterPro:IPR017972,NCBI_GP:CCP45868.1;Name=CCP45868.1;Note=Rv3059%2C (MTCY22D7.22c)%2C len: 492 aa. Probable cyp136%2C cytochrome P450 136%2C similar to other cytochrome P450-dependent oxidases e.g. Q59990|CYP120|CYP|SLR0574 putative cytochrome P450 120 from Synechocystis sp. strain PCC 6803 (444 aa)%2C FASTA scores: opt: 579%2C E(): 1.5e-29%2C(27.3%25 identity in 443 aa overlap)%3B Q64654|CYP51|CP51_RAT cytochrome P450 51 (lanosterol 14-alpha demethylase) from Rattus norvegicus (Rat) (503 aa)%2C FASTA scores: opt: 549%2CE(): 1.4e-27%2C (26.2%25 identity in 458 aa overlap)%3B Q9JIY3|CYP51 lanosterol 14-alpha-demethylase from Mus musculus (Mouse) (486 aa)%2C FASTA scores: opt: 546%2C E(): 2.1e-27%2C (25.75%25 identity in 458 aa overlap). Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp136;inference=protein motif:PROSITE:PS00086;locus_tag=Rv3059;product=Probable cytochrome P450 136 Cyp136;protein_id=CCP45868.1;transl_table=11
AL123456.3	EMBL	gene	3421741	3423213	.	-	.	ID=gene-Rv3060c;Name=Rv3060c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3060c
AL123456.3	EMBL	CDS	3421741	3423213	.	-	0	ID=cds-CCP45869.1;Parent=gene-Rv3060c;Dbxref=EnsemblGenomes-Gn:Rv3060c,EnsemblGenomes-Tr:CCP45869,GOA:P95098,InterPro:IPR000524,InterPro:IPR008920,InterPro:IPR011711,InterPro:IPR011991,UniProtKB/TrEMBL:P95098,NCBI_GP:CCP45869.1;Name=CCP45869.1;Note=Rv3060c%2C (MTCY22D7.21)%2C len: 490 aa. Probable transcriptional regulatory protein%2C showing reasonable similarity to several members of the GntR family e.g. BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti) (247 aa)%2C FASTA scores: opt: 274%2C E(): 3.5e-10%2C (30.35%25 identity in 224 aa overlap)%3B P96570|ESMR from Burkholderia cepacia (Pseudomonas cepacia) (277 aa)%2C FASTA scores: opt: 229%2C E(): 2.8e-07%2C (25.85%25 identity in 240 aa overlap)%3B Q9S276|SCI28.07 from Streptomyces coelicolor (230 aa)%2CFASTA scores: opt: 211%2C E(): 3.4e-06%2C (27.25%25 identity in 220 aa overlap)%3B etc. Seems to have two domains: residues 1-260 resemble UxuR%2C and 260-490 resemble PdhR%2C ExuR%2C etc. Contains bacterial regulatory proteins%2C GntR family signature (PS00043). Helix-turn-helix motif (+3.13 SD) at aa 38-59. Seems to belong to the GntR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00043;locus_tag=Rv3060c;product=Probable transcriptional regulatory protein (probably GntR-family);protein_id=CCP45869.1;transl_table=11
AL123456.3	EMBL	gene	3423262	3425427	.	-	.	ID=gene-Rv3061c;Name=fadE22;gbkey=Gene;gene=fadE22;gene_biotype=protein_coding;locus_tag=Rv3061c
AL123456.3	EMBL	CDS	3423262	3425427	.	-	0	ID=cds-CCP45870.1;Parent=gene-Rv3061c;Dbxref=EnsemblGenomes-Gn:Rv3061c,EnsemblGenomes-Tr:CCP45870,GOA:I6X654,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6X654,NCBI_GP:CCP45870.1;Name=CCP45870.1;Note=Rv3061c%2C (MTCY22D7.20)%2C len: 721 aa. Probable fadE22%2C Acyl-CoA Dehydrogenase%2C similar to many e.g. AAK44503|MT0284 from Mycobacterium tuberculosis strain CDC1551 (731 aa)%2C FASTA scores: opt: 1804%2C E(): 1.1e-101%2C(43.45%25 identity in 743 aa overlap)%3B AAK48037|MT3678 from Mycobacterium tuberculosis strain CDC1551 (711 aa)%2C FASTA scores: opt: 1630%2C E(): 3.9e-91%2C (42.55%25 identity in 733 aa overlap)%3B and extensive similarity in C-terminal part to many acyl-CoA dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter crescentus (407 aa)%2C FASTA scores: opt: 767%2CE(): 4.8e-39%2C (36.7%25 identity in 376 aa overlap). Also similar to many hypothetical proteins. Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE22;locus_tag=Rv3061c;product=Probable acyl-CoA dehydrogenase FadE22;protein_id=CCP45870.1;transl_table=11
AL123456.3	EMBL	gene	3425584	3427107	.	+	.	ID=gene-Rv3062;Name=ligB;gbkey=Gene;gene=ligB;gene_biotype=protein_coding;locus_tag=Rv3062
AL123456.3	EMBL	CDS	3425584	3427107	.	+	0	ID=cds-CCP45871.1;Parent=gene-Rv3062;Dbxref=EnsemblGenomes-Gn:Rv3062,EnsemblGenomes-Tr:CCP45871,GOA:P9WNV5,InterPro:IPR000977,InterPro:IPR012308,InterPro:IPR012309,InterPro:IPR012310,InterPro:IPR012340,InterPro:IPR016059,InterPro:IPR022865,NCBI_GP:CCP45871.1;Name=CCP45871.1;Note=Rv3062%2C (MTCY22D7.19c)%2C len: 507 aa. Probable ligB%2CDNA ligase ATP-dependent (see citation below)%2C highly similar to numerous archaebacterial and eukaryotic polynucleotide DNA ligases%2C e.g. Q9FCB1|DNLI_STRCO|LIG|2SCG58.02 from Streptomyces coelicolor (512 aa)%2C FASTA scores: opt: 1677%2C E(): 2.5e-90%2C(55.65%25 identity in 512 aa overlap)%3B Q9HR35|DNLI_HALN1|LIG|VNG0881G from Halobacterium sp. strain NRC-1 (561 aa)%2C FASTA scores: opt: 985%2C E(): 5.6e-50%2C (42.25%25 identity in 440 aa overlap)%3B Q9V185|DNLI_PYRAB|LIG|PAB2002 from Pyrococcus abyssi (559 aa)%2C FASTA scores: opt: 978%2C E(): 1.4e-49%2C (39.05%25 identity in 443 aa overlap)%3B etc. Also similar to Rv3731|MTV025.079|LIGC possible DNA ligase from M. tuberculosis (358 aa). Similarity at N-terminus is poor so first start codon was taken. Contains (PS00697) ATP-dependent DNA ligase AMP-binding site signature%2C and (PS00017) ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-dependent DNA ligase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ligB;inference=protein motif:PROSITE:PS00697;locus_tag=Rv3062;product=Probable ATP-dependent DNA ligase LigB (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase);protein_id=CCP45871.1;transl_table=11
AL123456.3	EMBL	gene	3427243	3429519	.	+	.	ID=gene-Rv3063;Name=cstA;gbkey=Gene;gene=cstA;gene_biotype=protein_coding;locus_tag=Rv3063
AL123456.3	EMBL	CDS	3427243	3429519	.	+	0	ID=cds-CCP45872.1;Parent=gene-Rv3063;Dbxref=EnsemblGenomes-Gn:Rv3063,EnsemblGenomes-Tr:CCP45872,GOA:P9WP47,InterPro:IPR003706,InterPro:IPR025299,NCBI_GP:CCP45872.1;Name=CCP45872.1;Note=Rv3063%2C (MTCY22D7.18c)%2C len: 758 aa. Probable cstA%2Cintegral membrane starvation-induced stress response protein%2C similar to other e.g. P15078|CSTA_ECOLI|B0598 from Escherichia coli strain K12 (701 aa)%2C FASTA scores: opt: 2357%2C E(): 9.5e-137%2C (51.25%25 identity in 712 aa overlap)%3B AAG54933|CSTA from Escherichia coli strain O157:H7 EDL933 (701 aa)%2C FASTA scores: opt: 2356%2C E(): 1.1e-136%2C (51.1%25 identity in 712 aa overlap)%3B etc. Predicted to be membrane associated. Similarity suggests start at GTG at 16801 in Y22D7 but no RBS obvious so TBParse-predicted start at 16881 taken. Belongs to the CstA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cstA;locus_tag=Rv3063;product=Probable carbon starvation protein A homolog CstA;protein_id=CCP45872.1;transl_table=11
AL123456.3	EMBL	gene	3429825	3430250	.	-	.	ID=gene-Rv3064c;Name=Rv3064c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3064c
AL123456.3	EMBL	CDS	3429825	3430250	.	-	0	ID=cds-CCP45873.1;Parent=gene-Rv3064c;Dbxref=EnsemblGenomes-Gn:Rv3064c,EnsemblGenomes-Tr:CCP45873,InterPro:IPR011637,UniProtKB/TrEMBL:I6XG31,NCBI_GP:CCP45873.1;Name=CCP45873.1;Note=Rv3064c%2C (MTCY22D7.17)%2C len: 141 aa. Probable conserved integral membrane protein%2C similar to many e.g. Q9KY40|SCC8A.08 putative integral membrane protein from Streptomyces coelicolor (153 aa)%2C FASTA scores: opt: 391%2CE(): 2.4e-18%2C (48.45%25 identity in 130 aa overlap)%3B Q9K461|SC2H12.23c putative integral membrane protein from Streptomyces coelicolor (151 aa)%2C FASTA scores: opt: 339%2CE(): 5.1e-15%2C (46.7%25 identity in 124 aa overlap)%3B BAB48975|MLR1652 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (130 aa)%2C FASTA scores: opt: 319%2C E(): 8.7e-14%2C (41.45%25 identity in 123 aa overlap)%3B Q9JR31|NMA2196|NMB0291 conserved hypothetical inner membrane protein from Neisseria meningitidis serogroup a and B (132 aa)%2C FASTA scores: opt: 303%2C E(): 9.4e-13%2C(43.65%25 identity in 126 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3064c;product=Probable conserved integral membrane protein;protein_id=CCP45873.1;transl_table=11
AL123456.3	EMBL	gene	3430387	3430710	.	+	.	ID=gene-Rv3065;Name=mmr;gbkey=Gene;gene=mmr;gene_biotype=protein_coding;gene_synonym=emrE;locus_tag=Rv3065
AL123456.3	EMBL	CDS	3430387	3430710	.	+	0	ID=cds-CCP45874.1;Parent=gene-Rv3065;Dbxref=EnsemblGenomes-Gn:Rv3065,EnsemblGenomes-Tr:CCP45874,GOA:P9WGF1,InterPro:IPR000390,PDB:2IQ4,NCBI_GP:CCP45874.1;Name=CCP45874.1;Note=Rv3065%2C (MT3150.1%2C MTCY22D7.17c)%2C len: 107 aa. Mmr%2Cintegral membrane multidrugs resistance transporter (see citation below)%2C equivalent to Q9CBP1|ML1756 probable multidrug resistance protein from Mycobacterium leprae (107 aa)%2C FASTA scores: opt: 534%2C E(): 3.3e-28%2C (77.55%25 identity in 107 aa overlap). Also highly similar to bacterial proteins involved in resistance to ethidium bromide or methyl viologen e.g. O87866|QACG_STASP quaternary ammonium compound-resistance protein QACG (quarternary ammonium determinant G) from Staphylococcus sp. strain ST94 (107 aa)%2C FASTA scores: opt: 307%2C E(): 1.8e-13%2C (39.8%25 identity in 103 aa overlap)%3B P96460|QAC quaternary ammonium compounds resistance protein QAC from Staphylococcus aureus (107 aa)%2C FASTA scores: opt: 304%2C E(): 2.8e-13%2C (40.4%25 identity in 104 aa overlap)%3B Q57225|QACE_ECOLI quaternary ammonium compound-resistance protein QACE (quarternary ammonium determinant E) from Escherichia coli (110 aa)%2CFASTA scores: opt: 300%2C E(): 5.2e-13%2C (48.15%25 identity in 108 aa overlap)%3B AAG55967|Z1870 methylviologen resistance protein encoded within prophage CP-933X from Escherichia coli strain O157:H7 EDL933 (110 aa)%3B P23895|EMRE|MVRC|EB|B0543 EMRE protein from Escherichia coli (110 aa)%2C FASTA scores: opt: 290%2C E(): 2.3e-12%2C(43.55%25 identity in 101 aa overlap)%3B etc. Also similar to the SugE protein of enteric bacteria. Belongs to the small multidrug resistance (SMR) protein family. Note that previously known as emrE.;gbkey=CDS;gene=mmr;locus_tag=Rv3065;product=Multidrugs-transport integral membrane protein Mmr;protein_id=CCP45874.1;transl_table=11
AL123456.3	EMBL	gene	3430707	3431315	.	+	.	ID=gene-Rv3066;Name=Rv3066;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3066
AL123456.3	EMBL	CDS	3430707	3431315	.	+	0	ID=cds-CCP45875.1;Parent=gene-Rv3066;Dbxref=EnsemblGenomes-Gn:Rv3066,EnsemblGenomes-Tr:CCP45875,GOA:I6X658,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,PDB:3T6N,UniProtKB/TrEMBL:I6X658,NCBI_GP:CCP45875.1;Name=CCP45875.1;Note=Rv3066%2C (MTCY22D7.15c)%2C len: 202 aa. Probable transcriptional regulatory protein deoR-family%2C with some similarity to transcriptional regulators and hypothetical proteins%2C e.g. Q9X9V5|SCI7.35c hypothetical 21.1 KDA protein from Streptomyces coelicolor (197 aa)%2C FASTA scores: opt: 398%2C E(): 5.7e-19%2C (40.3%25 identity in 191 aa overlap)%3B AAG55222|Z1073 putative DeoR-type transcriptional regulator from Escherichia coli strain O157:H7 EDL933 (178 aa)%2C FASTA scores: opt: 257%2C E(): 7.9e-10%2C (28.4%25 identity in 176 aa overlap)%3B Q9HXU1|PA3699 probable transcriptional regulator (TetR/AcrR family) from Pseudomonas aeruginosa (237 aa)%2C FASTA scores: opt: 229%2C E(): 6.7e-08%2C (32.1%25 identity in 187 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3066;product=Probable transcriptional regulatory protein (probably DeoR-family);protein_id=CCP45875.1;transl_table=11
AL123456.3	EMBL	gene	3431428	3431838	.	+	.	ID=gene-Rv3067;Name=Rv3067;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3067
AL123456.3	EMBL	CDS	3431428	3431838	.	+	0	ID=cds-CCP45876.1;Parent=gene-Rv3067;Dbxref=EnsemblGenomes-Gn:Rv3067,EnsemblGenomes-Tr:CCP45876,InterPro:IPR007969,UniProtKB/TrEMBL:I6YB21,NCBI_GP:CCP45876.1;Name=CCP45876.1;Note=Rv3067%2C (MTCY22D7.14c)%2C len: 136 aa. Conserved hypothetical protein%2C weakly similar to other mycobacterium proteins e.g. O53953|Rv1804c|MTV049.26c (108 aa)%2C FASTA scores: opt: 183%2C E(): 0.00053%2C (36.6%25 identity in 82 aa overlap)%3B O07222|Rv1810|MTCY16F9.04c (118 aa)%2C FASTA scores: opt: 149%2C E(): 0.05%2C (30.95%25 identity in 84 aa overlap). Has hydrophobic stretch at N-terminus. Start chosen on basis of codon usage but upstream ATG also possible.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3067;product=Conserved hypothetical protein;protein_id=CCP45876.1;transl_table=11
AL123456.3	EMBL	gene	3431840	3431912	.	-	.	ID=gene-alaU;Name=alaU;gbkey=Gene;gene=alaU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	3431840	3431912	.	-	.	ID=rna-alaU;Parent=gene-alaU;Note=codon recognized: GCC%3B alaU%2C tRNA-Ala%2C anticodon ggc%2C length %3D 73;anticodon=(pos:complement(3431877..3431879));gbkey=tRNA;gene=alaU;product=tRNA-Ala
AL123456.3	EMBL	exon	3431840	3431912	.	-	.	ID=exon-alaU-1;Parent=rna-alaU;Note=codon recognized: GCC%3B alaU%2C tRNA-Ala%2C anticodon ggc%2C length %3D 73;anticodon=(pos:complement(3431877..3431879));gbkey=tRNA;gene=alaU;product=tRNA-Ala
AL123456.3	EMBL	gene	3431979	3433622	.	-	.	ID=gene-Rv3068c;Name=pgmA;gbkey=Gene;gene=pgmA;gene_biotype=protein_coding;locus_tag=Rv3068c
AL123456.3	EMBL	CDS	3431979	3433622	.	-	0	ID=cds-CCP45877.1;Parent=gene-Rv3068c;Dbxref=EnsemblGenomes-Gn:Rv3068c,EnsemblGenomes-Tr:CCP45877,GOA:I6Y2G3,InterPro:IPR005843,InterPro:IPR005844,InterPro:IPR005845,InterPro:IPR005846,InterPro:IPR005852,InterPro:IPR016055,InterPro:IPR016066,UniProtKB/TrEMBL:I6Y2G3,NCBI_GP:CCP45877.1;Name=CCP45877.1;Note=Rv3068c%2C (MTCY22D7.13)%2C len: 547 aa. Probable pgmA%2Cphosphoglucomutase%2C highly similar to other phosphoglucomutases e.g. Q9L117|PGM from Streptomyces coelicolor (546 aa)%2C FASTA scores: opt: 2569%2C E(): 2.8e-149%2C (71.4%25 identity in 545 aa overlap)%3B Q9ABY5|CC0085 from Caulobacter crescentus (545 aa)%2C FASTA scores: opt: 2465%2C E(): 6.2e-143%2C (70.4%25 identity in 541 aa overlap)%3B P38569|PGMU_ACEXY|CELB from Acetobacter xylinum (555 aa)%2CFASTA scores: opt: 2206%2C E(): 4e-127%2C (62.25%25 identity in 543 aa overlap)%3B P74643|PGM|SLL0726 from Synechocystis sp. strain PCC 6803 (567 aa)%2C FASTA scores: opt: 2168%2C E(): 8.5e-125%2C (60.0%25 identity in 550 aa overlap)%3B P36938|PGMU_ECOLI|PGM|B0688 from Escherichia coli (546 aa)%2CFASTA scores: opt: 2111%2C E(): 2.5e-121%2C (58.2%25 identity in 550 aa overlap). Also similar to other phosphomannomutases. Has phosphoglucomutase and phosphomannomutase signature (PS00710) and ATP/GTP-binding site motif A (P-loop) (PS00017). Belongs to the phosphohexose mutases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pgmA;inference=protein motif:PROSITE:PS00710;locus_tag=Rv3068c;product=Probable phosphoglucomutase PgmA (glucose phosphomutase) (PGM);protein_id=CCP45877.1;transl_table=11
AL123456.3	EMBL	gene	3433692	3434090	.	+	.	ID=gene-Rv3069;Name=Rv3069;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3069
AL123456.3	EMBL	CDS	3433692	3434090	.	+	0	ID=cds-CCP45878.1;Parent=gene-Rv3069;Dbxref=EnsemblGenomes-Gn:Rv3069,EnsemblGenomes-Tr:CCP45878,GOA:P9WP63,InterPro:IPR003691,NCBI_GP:CCP45878.1;Name=CCP45878.1;Note=Rv3069%2C (MTCY22D7.12c)%2C len: 132 aa. Probable conserved transmembrane protein%2C similar to several hypothetical and CRCB bacterial proteins e.g. Q9A6V2|CC1981 CRCB protein (see citation below%3B seems to be involved in camphor resistance and chromosome condensation%2C promoting or protecting chromosome folding) from Caulobacter crescentus (127 aa)%2C FASTA scores: opt: 275%2C E(): 1.6e-11%2C(41.1%25 identity in 124 aa overlap)%3B Q9FC39|SC4G1.10 putative integral membrane protein from Streptomyces coelicolor (154 aa)%2C FASTA scores: opt: 258%2C E(): 2.5e-10%2C(42.15%25 identity in 121 aa overlap)%3B Q9V0X2|PAB1925 CRCB protein (see citation below) from Pyrococcus abyssi (123 aa)%2C FASTA scores: opt: 256%2C E(): 2.8e-10%2C (39.8%25 identity in 113 aa overlap)%3B O59171|PH1502 hypothetical 13.6 KDA protein from Pyrococcus horikoshii (123 aa)%2C FASTA scores: opt: 249%2C E(): 8.2e-10%2C (38.65%25 identity in 119 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3069;product=Probable conserved transmembrane protein;protein_id=CCP45878.1;transl_table=11
AL123456.3	EMBL	gene	3434087	3434467	.	+	.	ID=gene-Rv3070;Name=Rv3070;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3070
AL123456.3	EMBL	CDS	3434087	3434467	.	+	0	ID=cds-CCP45879.1;Parent=gene-Rv3070;Dbxref=EnsemblGenomes-Gn:Rv3070,EnsemblGenomes-Tr:CCP45879,GOA:P9WP61,InterPro:IPR003691,NCBI_GP:CCP45879.1;Name=CCP45879.1;Note=Rv3070%2C (MTCY22D7.11c)%2C len: 126 aa. Probable conserved integral membrane protein%2C similar to several hypothetical and CRCB bacterial proteins e.g. Q9FC37|SC4G1.12 putative integral membrane protein from Streptomyces coelicolor (124 aa)%2C FASTA scores: opt: 280%2CE(): 3.1e-11%2C (45.3%25 identity in 117 aa overlap)%3B O25823|HP1225 conserved hypothetical integral membrane protein from Helicobacter pylori (Campylobacter pylori) (130 aa)%2C FASTA scores: opt: 225%2C E(): 1e-07%2C (33.35%25 identity in 123 aa overlap)%3B O07590|YHDU hypothetical 12.4 KDA protein from Bacillus subtilis (118 aa)%2C FASTA scores: opt: 224%2C E(): 1.1e-07%2C (37.85%25 identity in 111 aa overlap)%3B Q9KVS9|VC0060 CRCB protein (see Hu et al.%2C 1996%3B seems involved in camphor resistance and chromosome condensation%2C promoting or protecting chromosome folding) from Vibrio cholera (126 aa)%2C FASTA scores: opt: 221%2C E(): 1.8e-07%2C (33.35%25 identity in 126 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3070;product=Probable conserved integral membrane protein;protein_id=CCP45879.1;transl_table=11
AL123456.3	EMBL	gene	3434464	3435573	.	+	.	ID=gene-Rv3071;Name=Rv3071;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3071
AL123456.3	EMBL	CDS	3434464	3435573	.	+	0	ID=cds-CCP45880.1;Parent=gene-Rv3071;Dbxref=EnsemblGenomes-Gn:Rv3071,EnsemblGenomes-Tr:CCP45880,GOA:P95087,InterPro:IPR003793,InterPro:IPR011322,InterPro:IPR015867,UniProtKB/TrEMBL:P95087,NCBI_GP:CCP45880.1;Name=CCP45880.1;Note=Rv3071%2C (MTCY22D7.10c)%2C len: 369 aa. Conserved hypothetical protein%2C weakly similar in N-terminus of Q9A4V0|CC2725 hypothetical protein CC2725 from Caulobacter crescentus (113 aa)%2C FASTA scores: opt: 141%2C E(): 0.031%2C(27.6%25 identity in 105 aa overlap). C-terminal region also weakly similar to other hypothetical proteins e.g. Q9FC38|YG11_STRCO from Streptomyces coelicolor (114 aa)%2CFASTA scores: opt: 151%2C E(): 0.007%2C (31.65%25 identity in 98 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3071;product=Conserved hypothetical protein;protein_id=CCP45880.1;transl_table=11
AL123456.3	EMBL	gene	3435798	3436322	.	-	.	ID=gene-Rv3072c;Name=Rv3072c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3072c
AL123456.3	EMBL	CDS	3435798	3436322	.	-	0	ID=cds-CCP45881.1;Parent=gene-Rv3072c;Dbxref=EnsemblGenomes-Gn:Rv3072c,EnsemblGenomes-Tr:CCP45881,GOA:P95086,InterPro:IPR011251,UniProtKB/TrEMBL:P95086,NCBI_GP:CCP45881.1;Name=CCP45881.1;Note=Rv3072c%2C (MTCY22D7.09)%2C len: 174 aa. Hypothetical protein%2C similar in part to O87779 hypothetical 18.1 KDA protein (fragment) from Mycobacterium paratuberculosis (166 aa)%2C FASTA scores: opt: 238%2C E(): 2.5e-08%2C (42.6%25 identity in 108 aa overlap)%3B Q9AH10 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa)%2C FASTA scores: opt: 228%2C E(): 1.7e-07%2C (34.25%25 identity in 111 aa overlap)%3B P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 possible oxidoreductase from Mycobacterium tuberculosis strain H37Rv (304 aa)%2C FASTA scores: opt: 208%2C E(): 3.2e-06%2C (38.9%25 identity in 108 aa overlap)%3B etc. N-terminal region similar to several proteins from Mycobacterium tuberculosis.;gbkey=CDS;locus_tag=Rv3072c;product=Conserved hypothetical protein;protein_id=CCP45881.1;transl_table=11
AL123456.3	EMBL	gene	3436329	3436685	.	-	.	ID=gene-Rv3073c;Name=Rv3073c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3073c
AL123456.3	EMBL	CDS	3436329	3436685	.	-	0	ID=cds-CCP45882.1;Parent=gene-Rv3073c;Dbxref=EnsemblGenomes-Gn:Rv3073c,EnsemblGenomes-Tr:CCP45882,InterPro:IPR007438,NCBI_GP:CCP45882.1;Name=CCP45882.1;Note=Rv3073c%2C (MTCY22D7.08)%2C len: 118 aa. Conserved hypothetical protein%2C highly similar to other e.g. Q9F3D7|SC2H2.18 from Streptomyces coelicolor (119 aa)%2CFASTA scores: opt: 399%2C E(): 2.5e-20%2C (53.05%25 identity in 115 aa overlap)%3B Q9K4K9|SC5F8.15c from Streptomyces coelicolor (117 aa)%2C FASTA scores: opt: 334%2C E(): 6e-16%2C(49.1%25 identity in 112 aa overlap)%3B Q9HKD5|TA0666 from Thermoplasma acidophilum (134 aa)%2C FASTA scores: opt: 334%2CE(): 6.7e-16%2C (42.35%25 identity in 111 aa overlap)%3B BAB53507|MLL7394 from Rhizobium loti (Mesorhizobium loti) (120 aa)%2C FASTA scores: opt: 309%2C E(): 3e-14%2C (43.65%25 identity in 110 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3073c;product=Conserved hypothetical protein;protein_id=CCP45882.1;transl_table=11
AL123456.3	EMBL	gene	3436779	3438053	.	+	.	ID=gene-Rv3074;Name=Rv3074;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3074
AL123456.3	EMBL	CDS	3436779	3438053	.	+	0	ID=cds-CCP45883.1;Parent=gene-Rv3074;Dbxref=EnsemblGenomes-Gn:Rv3074,EnsemblGenomes-Tr:CCP45883,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:I6XG38,NCBI_GP:CCP45883.1;Name=CCP45883.1;Note=Rv3074%2C (MTCY22D7.07c)%2C len: 424 aa. Conserved hypothetical protein%2C highly similar but shorter (46 aa) to P71806|Rv1378c|MTCY02B12.12c hypothetical 51.3 KDA protein from Mycobacterium tuberculosis (475 aa)%2C FASTA scores: opt: 2009%2C E(): 5.8e-113%2C (72.95%25 identity in 429 aa overlap)%3B and also similar to other hypothetical mycobacterium proteins e.g. O33266|Rv0336|MTCY279.03 (503 aa)%2C FASTA scores: opt: 337%2C E(): 7.5e-13%2C (28.6%25 identity in 381 aa overlap)%3B O33360|Rv0515|MTCY20G10.05 (503 aa)%2CFASTA scores: opt: 337%2C E(): 7.5e-13%2C (28.6%25 identity in 381 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3074;product=Conserved hypothetical protein;protein_id=CCP45883.1;transl_table=11
AL123456.3	EMBL	gene	3438050	3438973	.	-	.	ID=gene-Rv3075c;Name=Rv3075c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3075c
AL123456.3	EMBL	CDS	3438050	3438973	.	-	0	ID=cds-CCP45884.1;Parent=gene-Rv3075c;Dbxref=EnsemblGenomes-Gn:Rv3075c,EnsemblGenomes-Tr:CCP45884,GOA:I6YF40,InterPro:IPR005000,InterPro:IPR011206,InterPro:IPR015813,UniProtKB/TrEMBL:I6YF40,NCBI_GP:CCP45884.1;Name=CCP45884.1;Note=Rv3075c%2C (MTCY22D7.06)%2C len: 307 aa. Conserved protein%2C with some similarity to Q9I562|PA0883 probable acyl-CoA lyase beta chain from Pseudomonas aeruginosa (275 aa)%2C FASTA scores: opt: 408%2C E(): 9.2e-19%2C (35.15%25 identity in 273 aa overlap)%3B Q9S2U9|SC4G6.02 putative citrate lyase beta chain from Streptomyces coelicolor (274 aa)%2C FASTA scores: opt: 384%2C E(): 3.1e-17%2C (34.7%25 identity in 265 aa overlap)%3B O06162|cite|Rv2498c|MTCY07A7.04c from Mycobacterium tuberculosis (273 aa)%2C FASTA scores: opt: 349%2C E(): 5.1e-15%2C (35.2%25 identity in 264 aa overlap)%3B etc. Several initiation codons possible%2C first one chosen.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3075c;product=Conserved protein;protein_id=CCP45884.1;transl_table=11
AL123456.3	EMBL	gene	3439072	3439548	.	+	.	ID=gene-Rv3076;Name=Rv3076;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3076
AL123456.3	EMBL	CDS	3439072	3439548	.	+	0	ID=cds-CCP45885.1;Parent=gene-Rv3076;Dbxref=EnsemblGenomes-Gn:Rv3076,EnsemblGenomes-Tr:CCP45885,InterPro:IPR019587,InterPro:IPR023393,UniProtKB/TrEMBL:I6X666,NCBI_GP:CCP45885.1;Name=CCP45885.1;Note=Rv3076%2C (MTCY22D7.05c)%2C len: 158 aa. Conserved hypothetical protein%2C weakly similar to Q9AK12|SC8D11.07 hypothetical 17.0 KDA protein from Streptomyces coelicolor (151 aa)%2C FASTA scores: opt: 110%2C E(): 1.5%2C (25.5%25 identity in 145 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3076;product=Conserved hypothetical protein;protein_id=CCP45885.1;transl_table=11
AL123456.3	EMBL	gene	3439541	3441352	.	+	.	ID=gene-Rv3077;Name=Rv3077;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3077
AL123456.3	EMBL	CDS	3439541	3441352	.	+	0	ID=cds-CCP45886.1;Parent=gene-Rv3077;Dbxref=EnsemblGenomes-Gn:Rv3077,EnsemblGenomes-Tr:CCP45886,GOA:Q6MX15,InterPro:IPR000917,InterPro:IPR017849,InterPro:IPR017850,UniProtKB/TrEMBL:Q6MX15,NCBI_GP:CCP45886.1;Name=CCP45886.1;Note=Rv3077%2C (MTCY22D7.04c)%2C len: 603 aa. Possible hydrolase%2C with some similarity to variety of hydrolases (aryl- and steryl sulfatases principaly) e.g. Q45087|PEHA phosphonate monoester hydrolase from Burkholderia caryophylli (514 aa)%2C FASTA scores: opt: 239%2C E(): 7.2e-07%2C(23.95%25 identity in 413 aa overlap)%3B Q9I1E5|PA2333 probable sulfatase from Pseudomonas aeruginosa (538 aa)%2C FASTA scores: opt: 231%2C E(): 2.3e-06%2C (28.1%25 identity in 516 aa overlap)%3B P31447|YIDJ_ECOLI|B3678 putative sulfatase from Escherichia coli (497 aa)%2C FASTA scores: opt: 222%2C E(): 7.4e-06%2C (27.7%25 identity in 390 aa overlap)%3B etc. Note that previously known as atsF.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3077;product=Possible hydrolase;protein_id=CCP45886.1;transl_table=11
AL123456.3	EMBL	gene	3441353	3441754	.	+	.	ID=gene-Rv3078;Name=hab;gbkey=Gene;gene=hab;gene_biotype=protein_coding;locus_tag=Rv3078
AL123456.3	EMBL	CDS	3441353	3441754	.	+	0	ID=cds-CCP45887.1;Parent=gene-Rv3078;Dbxref=EnsemblGenomes-Gn:Rv3078,EnsemblGenomes-Tr:CCP45887,UniProtKB/TrEMBL:I6Y2H3,NCBI_GP:CCP45887.1;Name=CCP45887.1;Note=Rv3078%2C (MTCY22D7.03c)%2C len: 133 aa. Probable hab%2Chydroxylaminobenzene mutase (5.-.-.-) (see Davis et al.%2C2000)%2C highly similar to two hydroxylaminobenzene mutases from Pseudomonas pseudoalcaligenes O52214|HABA (135 aa)%2CFASTA scores: opt: 495%2C E(): 6.8e-25%2C (51.1%25 identity in 133 aa overlap)%3B and O52216|HABB (164 aa)%2C FASTA scores: opt: 479%2C E(): 8.2e-24%2C (51.9%25 identity in 133 aa overlap) (see Davis et al.%2C 2000)%3B and to Q9AH35|NBZB hydroxylaminobenzene mutase from Pseudomonas putida (164 aa)%2C FASTA scores: opt: 476%2C E(): 1.3e-23%2C (51.8%25 identity in 133 aa overlap) (see Park %26 Kim 2000). Gene name according to Pseudomonas pseudoalcaligenes nomenclature. Also similarity with putative different membrane proteins involved in transport (protein predicted to be a transmembrane protein).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hab;locus_tag=Rv3078;product=Probable hydroxylaminobenzene mutase Hab;protein_id=CCP45887.1;transl_table=11
AL123456.3	EMBL	gene	3441770	3442597	.	-	.	ID=gene-Rv3079c;Name=Rv3079c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3079c
AL123456.3	EMBL	CDS	3441770	3442597	.	-	0	ID=cds-CCP45888.1;Parent=gene-Rv3079c;Dbxref=EnsemblGenomes-Gn:Rv3079c,EnsemblGenomes-Tr:CCP45888,GOA:I6XG43,InterPro:IPR011251,InterPro:IPR019921,UniProtKB/TrEMBL:I6XG43,NCBI_GP:CCP45888.1;Name=CCP45888.1;Note=Rv3079c%2C (MTCY22D7.02)%2C len: 275 aa. Conserved protein%2C similar to other hypothetical mycobacterium proteins e.g. P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 possible oxidoreductase from Mycobacterium tuberculosis strain H37Rv (282 aa)%2C FASTA scores: opt: 668%2C E(): 2.4e-34%2C (40.55%25 identity in 281 aa overlap)%3B O06216|Rv2161c|MTCY270.07 from Mycobacterium tuberculosis strain H37Rv (288 aa)%2C FASTA scores: opt: 595%2C E(): 8.5e-30%2C (40.9%25 identity in 274 aa overlap)%3B O87779 from Mycobacterium paratuberculosis (166 aa)%2C FASTA scores: opt: 464%2C E(): 7.2e-22%2C (41.55%25 identity in 166 aa overlap)%3B etc. Also some similarity to other proteins e.g. Q9AH10 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa)%2C FASTA scores: opt: 401%2C E(): 9.6e-18%2C (30.2%25 identity in 288 aa overlap)%3B Q9AE04|RIF17 RIF17 protein from Amycolatopsis mediterranei (356 aa)%2CFASTA scores: opt: 298%2C E(): 2.8e-11%2C (35.0%25 identity in 203 aa overlap)%3B AAK48081|MT3720 luciferase-related protein from Mycobacterium tuberculosis strain CDC1551 (395 aa)%2CFASTA scores: opt: 223%2C E(): 1.4e-06%2C (29.4%25 identity in 211 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3079c;product=Conserved protein;protein_id=CCP45888.1;transl_table=11
AL123456.3	EMBL	gene	3442656	3445988	.	-	.	ID=gene-Rv3080c;Name=pknK;gbkey=Gene;gene=pknK;gene_biotype=protein_coding;locus_tag=Rv3080c
AL123456.3	EMBL	CDS	3442656	3445988	.	-	0	ID=cds-CCP45889.1;Parent=gene-Rv3080c;Dbxref=EnsemblGenomes-Gn:Rv3080c,EnsemblGenomes-Tr:CCP45889,GOA:P9WI65,InterPro:IPR000719,InterPro:IPR011009,InterPro:IPR011990,InterPro:IPR016236,InterPro:IPR017441,InterPro:IPR027417,NCBI_GP:CCP45889.1;Name=CCP45889.1;Note=Rv3080c%2C (MTV013.01c-MTCY22D7.01)%2C len: 1110 aa. pknK%2C serine/threonine protein kinase involved in transcriptional regulatory function (see citation below). Similar but shorter in N-terminus (approximately 300 residues) to others e.g. Q48411|ACOK transcriptional regulatory protein of aco ABCD operon from Klebsiella pneumoniae (921 aa)%2C FASTA scores: opt: 886%2C E(): 7.6e-37%2C(27.75%25 identity in 829 aa overlap)%3B Q9HX92|PA3921 probable transcriptional regulator from Pseudomonas aeruginosa (belongs to the LuxR/UhpA family of transcriptional regulators) (906 aa)%2C FASTA scores: opt: 760%2C E(): 1.5e-30%2C(29.55%25 identity in 822 aa overlap)%3B Q9I2X9|PA1760 probable transcriptional regulator from Pseudomonas aeruginosa (belongs to the LuxR/UhpA family of transcriptional regulators) (907 aa)%2C FASTA scores: opt: 696%2C E(): 2.3e-27%2C(25.85%25 identity in 685 aa overlap)%3B P06993|malt (alias BAB37683|ECS4260 and AAG58520|malt) positive regulator of MAL regulon from Escherichia coli strain O157:H7 (901 aa)%2CFASTA scores: opt: 660%2C E(): 1.4e-25%2C (29.25%25 identity in 530 aa overlap)%3B Q9KNF3|VCA0011 malt regulatory protein from Vibrio cholerae (belongs to the LuxR/UhpA family of transcriptional regulators) (921 aa)%2C FASTA scores: opt: 626%2C E(): 7.2e-24%2C (25.8%25 identity in 659 aa overlap)%3B etc. N-terminal region similar to N-terminus of serine/threonine kinases e.g. Q9KK90|PKMA serine/threonine kinase (similar to the Ser/Thr family of protein kinases) from Amycolatopsis mediterranei (589 aa)%2C FASTA scores: opt: 545%2C E(): 5.7e-20%2C (34.45%25 identity in 334 aa overlap)%3B Q9RPT5|AMK serine/threonine protein kinase homolog (similar to the Ser/Thr family of protein kinases) from Amycolatopsis mediterranei (606 aa)%2C FASTA scores: opt: 537%2C E(): 1.5e-19%2C (35.55%25 identity in 346 aa overlap)%3B Q9L0I0|PKAD protein serine/threonine kinase from Streptomyces coelicolor (599 aa)%2C FASTA scores: opt: 520%2CE(): 1e-18%2C (36.1%25 identity in 324 aa overlap)%3B etc. N-terminal part also similar to O53510|PKNL_MYCTU|Rv2176|MT2232|MTV021.09 probable serine/threonine-protein kinase from Mycobacterium tuberculosis strain H37Rv (399 aa)%2C FASTA scores: opt: 511%2CE(): 2.1e-18%2C (35.15%25 identity in 313 aa overlap). Contains PS00107 Protein kinases ATP-binding region signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains Hank's kinase subdomain. First part of the protein seems belong to the Ser/Thr family of protein kinases%2C and second parts seems belongs to the LuxR/UhpA family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pknK;inference=protein motif:PROSITE:PS00107;locus_tag=Rv3080c;product=Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K);protein_id=CCP45889.1;transl_table=11
AL123456.3	EMBL	gene	3446040	3447278	.	+	.	ID=gene-Rv3081;Name=Rv3081;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3081
AL123456.3	EMBL	CDS	3446040	3447278	.	+	0	ID=cds-CCP45890.1;Parent=gene-Rv3081;Dbxref=EnsemblGenomes-Gn:Rv3081,EnsemblGenomes-Tr:CCP45890,GOA:O53298,InterPro:IPR018700,UniProtKB/TrEMBL:O53298,NCBI_GP:CCP45890.1;Name=CCP45890.1;Note=Rv3081%2C (MTV013.02)%2C len: 412 aa. Conserved hypothetical protein. Second part of the protein (approximately residues 250-412) shares weak similarity with other hypothetical proteins e.g. Q9YEU3|APE0488 from Aeropyrum pernix (188 aa)%2C FASTA scores: opt: 149%2C E(): 0.019%2C E(): 0.019%2C (29.5%25 identity in 173 aa overlap)%3B and first part shares weak similarity with C-terminal part of Q9RVT9|DR0933 alpha-amlyase from Deinococcus radiodurans (644 aa)%2C FASTA scores: opt: 127%2C E(): 1.4%2C (27.25%25 identity in 198 aa overlap). Equivalent to AAK47502|MT3166 hypothetical 48.3 KDA protein from Mycobacterium tuberculosis strain CDC1551 (436 aa) but shorter 24 aa in N-terminus. Contains PS00850 Glycine radical signature and possible helix-turn-helix motif at aa 53-74.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00850;locus_tag=Rv3081;product=Conserved hypothetical protein;protein_id=CCP45890.1;transl_table=11
AL123456.3	EMBL	gene	3447404	3448426	.	-	.	ID=gene-Rv3082c;Name=virS;gbkey=Gene;gene=virS;gene_biotype=protein_coding;locus_tag=Rv3082c
AL123456.3	EMBL	CDS	3447404	3448426	.	-	0	ID=cds-CCP45891.1;Parent=gene-Rv3082c;Dbxref=EnsemblGenomes-Gn:Rv3082c,EnsemblGenomes-Tr:CCP45891,GOA:P9WMJ3,InterPro:IPR009057,InterPro:IPR018060,NCBI_GP:CCP45891.1;Name=CCP45891.1;Note=Rv3082c%2C (MT3167%2C MTV013.03c)%2C len: 340 aa. VirS%2Ctranscriptional regulatory protein araC/xylS family%2Cprobably involved in virulence (see citations below). Similar to many transcriptional regulators araC/xylS family e.g. Q9HZ25|PA3215 probable transcriptional regulator (AraC/XylS family) from Pseudomonas aeruginosa (337 aa)%2CFASTA scores: opt: 379%2C E(): 3e-17%2C (30.4%25 identity in 306 aa overlap)%3B Q9Z3Y6|PHBR polyhydroxybutyrate transcriptional activator from Pseudomonas sp. 61-3 (379 aa)%2C FASTA scores: opt: 336%2C E(): 2e-14%2C (26.35%25 identity in 334 aa overlap)%3B P72171|ORUR|PA0831 ornithine utilization transcriptional regulator oruR from Pseudomonas aeruginosa (339 aa)%2C FASTA scores: opt: 274%2C E(): 1.9e-10%2C(23.7%25 identity in 321 aa overlap)%3B Q9ZFW7 virulence regulating homolog from Pseudomonas alcaligenes (346 aa)%2CFASTA scores: opt: 262%2C E(): 1.2e-09%2C (24.5%25 identity in 339 aa overlap)%3B etc. Also similar to O69703|Rv3736|MTV025.084 putative regulatory protein (AraC/XylS family) from Mycobacterium tuberculosis strain H37Rv (353 aa)%2C FASTA scores: opt: 656%2C E(): 3.5e-35%2C(36.95%25 identity in 333 aa overlap). Has potential helix-turn-helix motif at positions 252-273. Belongs to the AraC/XylS family of transcriptional regulators. Substrate of PknK.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=virS;locus_tag=Rv3082c;product=Virulence-regulating transcriptional regulator VirS (AraC/XylS family);protein_id=CCP45891.1;transl_table=11
AL123456.3	EMBL	gene	3448504	3449991	.	+	.	ID=gene-Rv3083;Name=Rv3083;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3083
AL123456.3	EMBL	CDS	3448504	3449991	.	+	0	ID=cds-CCP45892.1;Parent=gene-Rv3083;Dbxref=EnsemblGenomes-Gn:Rv3083,EnsemblGenomes-Tr:CCP45892,GOA:P9WNF7,NCBI_GP:CCP45892.1;Name=CCP45892.1;Note=Rv3083%2C (MTV013.04)%2C len: 495 aa. Probable monooxygenase%2C highly similar to other putative monooxygenases flavin-binding family e.g. AAK48336|MT3969 from Mycobacterium tuberculosis strain CDC1551 (489 aa)%2CFASTA scores: opt: 1692%2C E(): 4.9e-98%2C (49.7%25 identity in 489 aa overlap)%3B Q9A588|CC2569 from Caulobacter crescentus (498 aa)%2C FASTA scores: opt: 1684%2C E(): 1.6e-97%2C (52.25%25 identity in 484 aa overlap)%3B Q9APW3 from Pseudomonas aeruginosa (508 aa)%2C FASTA scores: opt: 1603%2C E(): 1.8e-92%2C(49.8%25 identity in 484 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3083;product=Probable monooxygenase (hydroxylase);protein_id=CCP45892.1;transl_table=11
AL123456.3	EMBL	gene	3449997	3450923	.	+	.	ID=gene-Rv3084;Name=lipR;gbkey=Gene;gene=lipR;gene_biotype=protein_coding;locus_tag=Rv3084
AL123456.3	EMBL	CDS	3449997	3450923	.	+	0	ID=cds-CCP45893.1;Parent=gene-Rv3084;Dbxref=EnsemblGenomes-Gn:Rv3084,EnsemblGenomes-Tr:CCP45893,GOA:P9WK85,InterPro:IPR013094,InterPro:IPR029058,NCBI_GP:CCP45893.1;Name=CCP45893.1;Note=Rv3084%2C (MTV013.05)%2C len: 308 aa. Probable lipR%2CN-Acetyl-hydrolase/esterase%2C similar to other e.g. Q01109|BAH_STRH from Streptomyces hygroscopicus (299 aa)%2CFASTA scores: opt: 558%2C E(): 4.1e-26%2C (40.25%25 identity in 246 aa overlap)%3B Q9X8J4|SCE9.22 from Streptomyces coelicolor (266 aa)%2C FASTA scores: opt: 544%2C E(): 2.5e-25%2C(36.95%25 identity in 257 aa overlap)%3B Q56171|DEA from Streptomyces viridochromogenes (299 aa)%2C FASTA scores: opt: 532%2C E(): 1.4e-24%2C (38.6%25 identity in 254 aa overlap)%3B etc. Also similar to O06350|LIPF|Rv3487c|MTCY13E12.41c (277 aa)%2CFASTA score: opt: 291%2C E(): 8.5e-10%2C (28.5%25 identity in 239 aa overlap). May belong to the 'GDXG' family of lipolytic enzymes.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipR;locus_tag=Rv3084;product=Probable acetyl-hydrolase/esterase LipR;protein_id=CCP45893.1;transl_table=11
AL123456.3	EMBL	gene	3450920	3451750	.	+	.	ID=gene-Rv3085;Name=Rv3085;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3085
AL123456.3	EMBL	CDS	3450920	3451750	.	+	0	ID=cds-CCP45894.1;Parent=gene-Rv3085;Dbxref=EnsemblGenomes-Gn:Rv3085,EnsemblGenomes-Tr:CCP45894,GOA:P9WGP9,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP45894.1;Name=CCP45894.1;Note=Rv3085%2C (MTV013.06)%2C len: 276 aa. Probable short-chain dehydrogenase/reductase%2C similar to various oxidoreductases in the short chain dehydrogenases/reductases family e.g. Q9CC98|ML1094 short chain alcohol dehydrogenase from Mycobacterium leprae (277 aa)%2C FASTA scores: opt: 1059%2C E(): 4.8e-56%2C (61.65%25 identity in 266 aa overlap)%3B Q9I3H6|PA1537 probable short-chain dehydrogenase from Pseudomonas aeruginos (295 aa)%2C FASTA scores: opt: 858%2C E(): 4.7e-44%2C (48.4%25 identity in 285 aa overlap)%3B Q9CBP7|ML1740 possible short chain reductase from Mycobacterium leprae (312 aa)%2C FASTA scores: opt: 500%2C E(): 1e-22%2C (36.6%25 identity in 257 aa overlap)%3B etc. Also similar to mycobacterium proteins O50460|Rv1245c|MTV006.17c dehydrogenase similar to the short-chain dehydrogenases/reductases family (276 aa)%2CFASTA scores: opt: 1200%2C E(): 1.9e-64%2C (65.2%25 identity in 273 aa overlap)%3B and P95101|Rv3057c|MTCY22D7.24 hypothetical dehydrogenase (287 aa). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv3085;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP45894.1;transl_table=11
AL123456.3	EMBL	gene	3451781	3452887	.	+	.	ID=gene-Rv3086;Name=adhD;gbkey=Gene;gene=adhD;gene_biotype=protein_coding;locus_tag=Rv3086
AL123456.3	EMBL	CDS	3451781	3452887	.	+	0	ID=cds-CCP45895.1;Parent=gene-Rv3086;Dbxref=EnsemblGenomes-Gn:Rv3086,EnsemblGenomes-Tr:CCP45895,GOA:P9WQB9,InterPro:IPR002085,InterPro:IPR002328,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,InterPro:IPR023921,NCBI_GP:CCP45895.1;Name=CCP45895.1;Note=Rv3086%2C (MTV013.07)%2C len: 368 aa. Probable adhD%2Czinc-type alcohol dehydrogenase%2C highly similar to many e.g. O69045 hypothetical alcohol dehydrogenase from Rhodococcus rhodochrous (370 aa)%2C FASTA scores: opt: 1255%2CE(): 8.7e-68%2C (50.4%25 identity in 367 aa overlap)%3B P25406|ADHB_UROHA alcohol dehydrogenase I-B from Uromastyx hardwickii (Indian spiny-tailed lizard) (375 aa)%2C FASTA scores: opt: 787%2C E(): 8.2e-40%2C (35.9%25 identity in 373 aa overlap)%3B P72324||ADHI_RHOSH alcohol dehydrogenase class III from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (376 aa)%2C FASTA scores: opt: 787%2C E(): 8.3e-40%2C (35.1%25 identity in 379 aa overlap). Also highly similar to P71818|Rv0761c|MTCY369.06c hypothetical zinc-type alcohol dehydrogenase-like protein from Mycobacterium tuberculosis strain H37Rv (375 aa)%2C FASTA scores: opt: 1186%2C E(): 1.2e-63%2C (47.3%25 identity in 368 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. Belongs to the zinc-containing alcohol dehydrogenase. Possibly requires zinc for its activity.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=adhD;inference=protein motif:PROSITE:PS00059;locus_tag=Rv3086;product=Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase);protein_id=CCP45895.1;transl_table=11
AL123456.3	EMBL	gene	3452925	3454343	.	+	.	ID=gene-Rv3087;Name=Rv3087;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3087
AL123456.3	EMBL	CDS	3452925	3454343	.	+	0	ID=cds-CCP45896.1;Parent=gene-Rv3087;Dbxref=EnsemblGenomes-Gn:Rv3087,EnsemblGenomes-Tr:CCP45896,GOA:P9WKB1,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP45896.1;Name=CCP45896.1;Note=Rv3087%2C (MTV013.08)%2C len: 472 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C similar to several Mycobacterium tuberculosis proteins e.g. MTCY08D5.16%2C MTCY28.26%2C MTCY493.29c. Also similar to Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from Mycobacterium leprae (491 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3087;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP45896.1;transl_table=11
AL123456.3	EMBL	gene	3454340	3455764	.	+	.	ID=gene-Rv3088;Name=tgs4;gbkey=Gene;gene=tgs4;gene_biotype=protein_coding;locus_tag=Rv3088
AL123456.3	EMBL	CDS	3454340	3455764	.	+	0	ID=cds-CCP45897.1;Parent=gene-Rv3088;Dbxref=EnsemblGenomes-Gn:Rv3088,EnsemblGenomes-Tr:CCP45897,GOA:P9WKC3,InterPro:IPR004255,InterPro:IPR009721,InterPro:IPR014292,NCBI_GP:CCP45897.1;Name=CCP45897.1;Note=Rv3088%2C (MTV013.09)%2C len: 474 aa. Putative tgs4%2Ctriacylglycerol synthase (See Daniel et al.%2C 2004)%2C similar to several Mycobacterium tuberculosis proteins e.g. MTCY31.23 (505 aa)%2C MTCY13E12.34c (497 aa) and MTCY493.29c (459 aa). Also similar to Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from Mycobacterium leprae (491 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tgs4;locus_tag=Rv3088;product=Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4;protein_id=CCP45897.1;transl_table=11
AL123456.3	EMBL	gene	3455761	3457272	.	+	.	ID=gene-Rv3089;Name=fadD13;gbkey=Gene;gene=fadD13;gene_biotype=protein_coding;locus_tag=Rv3089
AL123456.3	EMBL	CDS	3455761	3457272	.	+	0	ID=cds-CCP45898.1;Parent=gene-Rv3089;Dbxref=EnsemblGenomes-Gn:Rv3089,EnsemblGenomes-Tr:CCP45898,GOA:P9WQ37,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,PDB:3R44,PDB:3T5B,PDB:3T5C,NCBI_GP:CCP45898.1;Name=CCP45898.1;Note=Rv3089%2C (MTV013.10)%2C len: 503 aa. Probable fadD13%2CAcyl-CoA Synthetase%2C similar to many e.g. MTCI28.06%2CMTCY08D5.09%2C MTCY06G11.08 from Mycobacterium tuberculosis strain H37Rv%3B and to Q9F7P5 predicted acid--CoA ligase FADD13 from uncultured proteobacterium EBAC31A08 (504 aa)%2CFASTA scores: opt: 1126%2C E(): 2.4e-62%2C (38.85%25 identity in 502 aa overlap)%3B Q9EY88|FCS feruloyl-CoA synthetase from Amycolatopsis sp. strain HR167 (491 aa)%2C FASTA scores: opt: 1073%2C E(): 4.5e-59%2C (38.5%25 identity in 504 aa overlap)%3B BAB49118|MLR1843 probable acid-CoA ligase from Rhizobium loti (Mesorhizobium loti) (495 aa)%2C FASTA scores: opt: 937%2CE(): 1.2e-50%2C (36.2%25 identity in 503 aa overlap)%3B Q9KZC1|SC6F7.21 probable long-chain-fatty-acid-CoA ligase from Streptomyces coelicolor (511 aa)%2C FASTA scores: opt: 899%2C E(): 2.8e-48%2C (36.1%25 identity in 510 aa overlap)%3B Q9A5P7|CC2400 putative acid-CoA ligase from Caulobacter crescentus (496 aa)%2C FASTA scores: opt: 874%2C E(): 9.8e-47%2C(35.1%25 identity in 507 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature and PS00061 Short-chain alcohol dehydrogenase family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD13;inference=protein motif:PROSITE:PS00455;locus_tag=Rv3089;product=Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase);protein_id=CCP45898.1;transl_table=11
AL123456.3	EMBL	gene	3458211	3459098	.	+	.	ID=gene-Rv3090;Name=Rv3090;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3090
AL123456.3	EMBL	CDS	3458211	3459098	.	+	0	ID=cds-CCP45899.1;Parent=gene-Rv3090;Dbxref=EnsemblGenomes-Gn:Rv3090,EnsemblGenomes-Tr:CCP45899,GOA:O05769,InterPro:IPR001107,UniProtKB/TrEMBL:O05769,NCBI_GP:CCP45899.1;Name=CCP45899.1;Note=Rv3090%2C (MTCY164.01)%2C len: 295 aa. Unknown Ala-%2CVal-rich protein. Hydrophobic stretch at N-terminus.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3090;product=Unknown alanine and valine rich protein;protein_id=CCP45899.1;transl_table=11
AL123456.3	EMBL	gene	3459116	3460807	.	+	.	ID=gene-Rv3091;Name=Rv3091;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3091
AL123456.3	EMBL	CDS	3459116	3460807	.	+	0	ID=cds-CCP45900.1;Parent=gene-Rv3091;Dbxref=EnsemblGenomes-Gn:Rv3091,EnsemblGenomes-Tr:CCP45900,GOA:I6YB49,InterPro:IPR002641,InterPro:IPR016035,UniProtKB/TrEMBL:I6YB49,NCBI_GP:CCP45900.1;Name=CCP45900.1;Note=Rv3091%2C (MTCY164.02)%2C len: 563 aa. Conserved protein%2C similar in part to O60859 neuropathy target esterase from Homo sapiens (Human) (1327 aa)%2C FASTA scores: opt: 177%2C E(): 0.0062%2C (30.65%25 identity in 173 aa overlap)%3B and Q9I385|PA1640 hypothetical protein from Pseudomonas aeruginosa (345 aa)%2C FASTA scores: opt: 152%2C E(): 0.069%2C(27.8%25 identity in 180 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3091;product=Conserved protein;protein_id=CCP45900.1;transl_table=11
AL123456.3	EMBL	gene	3460814	3461734	.	-	.	ID=gene-Rv3092c;Name=Rv3092c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3092c
AL123456.3	EMBL	CDS	3460814	3461734	.	-	0	ID=cds-CCP45901.1;Parent=gene-Rv3092c;Dbxref=EnsemblGenomes-Gn:Rv3092c,EnsemblGenomes-Tr:CCP45901,InterPro:IPR008526,UniProtKB/TrEMBL:I6Y2I9,NCBI_GP:CCP45901.1;Name=CCP45901.1;Note=Rv3092c%2C (MTCY164.03c)%2C len: 306 aa. Probable conserved integral membrane protein%2C highly similar to Q9RUT5|DR1297 conserved hypothetical protein from Deinococcus radiodurans (311 aa)%2C FASTA scores: opt: 941%2CE(): 9.8e-51%2C (55.65%25 identity in 309 aa overlap)%3B Q9A8B8|CC1436 hypothetical protein from Caulobacter crescentus (314 aa)%2C FASTA scores: opt: 791%2C E(): 1.6e-41%2C(46.9%25 identity in 305 aa overlap)%3B and also highly similar to Q9I2N8|PA1857 hypothetical protein from Pseudomonas aeruginosa (307 aa)%2C FASTA scores: opt: 373%2C E(): 8.1e-16%2C(40.8%25 identity in 321 aa overlap)%3B BAB36119|ECS2696 putative methyl-independent mismatch repair protein from Escherichia coli strain O157:H7 (305 aa)%2C FASTA scores: opt: 335%2C E(): 1.7e-13%2C (39.75%25 identity in 307 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3092c;product=Probable conserved integral membrane protein;protein_id=CCP45901.1;transl_table=11
AL123456.3	EMBL	gene	3461760	3462764	.	-	.	ID=gene-Rv3093c;Name=Rv3093c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3093c
AL123456.3	EMBL	CDS	3461760	3462764	.	-	0	ID=cds-CCP45902.1;Parent=gene-Rv3093c;Dbxref=EnsemblGenomes-Gn:Rv3093c,EnsemblGenomes-Tr:CCP45902,GOA:O05772,InterPro:IPR011251,InterPro:IPR022526,UniProtKB/TrEMBL:O05772,NCBI_GP:CCP45902.1;Name=CCP45902.1;Note=Rv3093c%2C (MTCY164.04c)%2C len: 334 aa. Hypothetical oxidoreductase%2C with some similarity with various oxidoreductases e.g. Q58929|mer|MJ1534 N5%2CN10-methylene tetrahydromethanopterin reductase from Methanococcus jannaschii (331 aa)%2C FASTA scores: opt: 300%2C E(): 1.1e-10%2C(24.1%25 identity in 324 aa overlap)%3B and Q9ZA30|GRA-ORF29 putative FMN-dependent monooxygenase from Streptomyces violaceoruber (343 aa)%2C FASTA scores: opt: 264%2C E(): 1.5e-08%2C (30.45%25 identity in 335 aa overlap)%3B Q9CCV8|ML0348 possible coenzyme F420-dependent oxidoreductase from Mycobacterium leprae (350 aa)%2C FASTA scores: opt: 220%2C E(): 6.4e-06%2C (26.5%25 identity in 328 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3093c;product=Hypothetical oxidoreductase;protein_id=CCP45902.1;transl_table=11
AL123456.3	EMBL	gene	3462761	3463891	.	-	.	ID=gene-Rv3094c;Name=Rv3094c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3094c
AL123456.3	EMBL	CDS	3462761	3463891	.	-	0	ID=cds-CCP45903.1;Parent=gene-Rv3094c;Dbxref=EnsemblGenomes-Gn:Rv3094c,EnsemblGenomes-Tr:CCP45903,GOA:O05773,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013107,InterPro:IPR013786,UniProtKB/TrEMBL:O05773,NCBI_GP:CCP45903.1;Name=CCP45903.1;Note=Rv3094c%2C (MTCY164.05c)%2C len: 376 aa. Conserved hypothetical protein%2C some similarity with various proteins e.g. Q9RMR9|NRGC NRGC protein (corresponding gene seems regulated by NifA) from Bradyrhizobium japonicum (388 aa)%2CFASTA scores: opt: 677%2C E(): 5.8e-35%2C (34.55%25 identity in 353 aa overlap)%3B P26698|PIGM_RHOSO pigment protein from Rhodococcus sp. strain ATCC 21145 (387 aa)%2C FASTA scores: opt: 480%2C E(): 1.2e-22%2C (28.7%25 identity in 376 aa overlap)%3B Q9F0J3|NCNH hydroxylase from Streptomyces arenae (405 aa)%2CFASTA scores: opt: 441%2C E(): 3.3e-20%2C (29.25%25 identity in 352 aa overlap)%3B etc. Equivalent to AAK47516 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but N-terminus shorter 19 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3094c;product=Conserved hypothetical protein;protein_id=CCP45903.1;transl_table=11
AL123456.3	EMBL	gene	3463973	3464449	.	+	.	ID=gene-Rv3095;Name=Rv3095;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3095
AL123456.3	EMBL	CDS	3463973	3464449	.	+	0	ID=cds-CCP45904.1;Parent=gene-Rv3095;Dbxref=EnsemblGenomes-Gn:Rv3095,EnsemblGenomes-Tr:CCP45904,GOA:P9WMG3,InterPro:IPR002577,InterPro:IPR011991,NCBI_GP:CCP45904.1;Name=CCP45904.1;Note=Rv3095%2C (MTCY164.06)%2C len: 158 aa. Possible regulatory protein%2C because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa)%2C FASTA scores: opt: 486%2C E(): 1.6e-25%2C(45.95%25 identity in 148 aa overlap)%3B Q9AAF6|CC0645 from Caulobacter crescentus (188 aa)%2C FASTA scores: opt: 479%2CE(): 5.3e-25%2C (45.75%25 identity in 153 aa overlap)%3B Q9K408|2SCG61.07 from Streptomyces coelicolor (157 aa)%2CFASTA scores: opt: 407%2C E(): 2.8e-20%2C (43.9%25 identity in 139 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3095;product=Hypothetical transcriptional regulatory protein;protein_id=CCP45904.1;transl_table=11
AL123456.3	EMBL	gene	3464547	3465686	.	+	.	ID=gene-Rv3096;Name=Rv3096;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3096
AL123456.3	EMBL	CDS	3464547	3465686	.	+	0	ID=cds-CCP45905.1;Parent=gene-Rv3096;Dbxref=EnsemblGenomes-Gn:Rv3096,EnsemblGenomes-Tr:CCP45905,GOA:I6YB54,InterPro:IPR013781,InterPro:IPR017853,InterPro:IPR024778,UniProtKB/TrEMBL:I6YB54,NCBI_GP:CCP45905.1;Name=CCP45905.1;Note=Rv3096%2C (MTCY164.07)%2C len: 379 aa. Hypothetical protein%2C with slight similarity to several proteins e.g. Q09671|OYEB_SCHPO|SPAC5H10.10 putative NADPH dehydrogenase C5H10.10 (old yellow enzyme homolog) from Schizosaccharomyces pombe (Fission yeast) (392 aa)%2C FASTA scores: opt: 125%2C E(): 1.1%2C (25.45%25 identity in 165 aa overlap)%3B and Q12603|XYNA_DICTH beta-1%2C4-xylanase (endo-1%2C4-beta-xylanase) from Dictyoglomus thermophilum (352 aa)%2C FASTA scores: opt: 124%2C E(): 1.2%2C (25.65%25 identity in 195 aa overlap)%3B etc. Contains glycosyl hydrolases family 5 signature (PS00659). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00659;locus_tag=Rv3096;product=Conserved hypothetical protein;protein_id=CCP45905.1;transl_table=11
AL123456.3	EMBL	gene	3465778	3467091	.	-	.	ID=gene-Rv3097c;Name=lipY;gbkey=Gene;gene=lipY;gene_biotype=protein_coding;gene_synonym=PE_PGRS63;locus_tag=Rv3097c
AL123456.3	EMBL	CDS	3465778	3467091	.	-	0	ID=cds-CCP45906.1;Parent=gene-Rv3097c;Dbxref=EnsemblGenomes-Gn:Rv3097c,EnsemblGenomes-Tr:CCP45906,GOA:I6Y2J4,InterPro:IPR000084,InterPro:IPR013094,InterPro:IPR029058,UniProtKB/TrEMBL:I6Y2J4,NCBI_GP:CCP45906.1;Name=CCP45906.1;Note=Rv3097c%2C (MTCY164.08c)%2C len: 437 aa. LipY%2Ctriacylglycerol lipase. Belongs to the hormone-sensitive lipase family (See Deb et al.%2C 2006) and member of the M. tuberculosis PE-family PGRS subfamily of gly-rich proteins (see citation below)%3B N-terminal part similar to N-terminus of M. tuberculosis PE-PGRS family members e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich 49.6 kDa protein (603 aa). Other relatives include MTCY1A11.25c%3B MTCY21B4.13c%3B MTCY270.06%3B MTCY359.33%3B MTC1A11.04. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipY;locus_tag=Rv3097c;product=PE-PGRS family protein%2C triacylglycerol lipase LipY (esterase/lipase) (triglyceride lipase) (tributyrase);protein_id=CCP45906.1;transl_table=11
AL123456.3	EMBL	gene	3467210	3467662	.	-	.	ID=gene-Rv3098c;Name=Rv3098c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3098c
AL123456.3	EMBL	CDS	3467210	3467662	.	-	0	ID=cds-CCP45907.1;Parent=gene-Rv3098c;Dbxref=EnsemblGenomes-Gn:Rv3098c,EnsemblGenomes-Tr:CCP45907,UniProtKB/TrEMBL:O05776,NCBI_GP:CCP45907.1;Name=CCP45907.1;Note=Rv3098c%2C (MTCY164.09c)%2C len: 150 aa. Hypothetical unknown protein (shorter version of MTCY164.09c). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3098c;product=Hypothetical protein;protein_id=CCP45907.1;transl_table=11
AL123456.3	EMBL	gene	3467606	3467926	.	+	.	ID=gene-Rv3098A;Name=Rv3098A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3098A
AL123456.3	EMBL	CDS	3467606	3467926	.	+	0	ID=cds-CCP45908.1;Parent=gene-Rv3098A;Dbxref=EnsemblGenomes-Gn:Rv3098A,EnsemblGenomes-Tr:CCP45908,GOA:V5QRX7,InterPro:IPR003477,InterPro:IPR011067,UniProtKB/TrEMBL:V5QRX7,NCBI_GP:CCP45908.1;Name=CCP45908.1;Note=Rv3098A%2C len: 106 aa. PemK-like protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3098A;product=PemK-like protein;protein_id=CCP45908.1;transl_table=11
AL123456.3	EMBL	gene	3467967	3468334	.	-	.	ID=gene-ssr;Name=ssr;gbkey=Gene;gene=ssr;gene_biotype=misc_RNA
AL123456.3	EMBL	transcript	3467967	3468334	.	-	.	ID=rna-ssr;Parent=gene-ssr;Note=ssr%2C match to EM_BA:MT10SARNA X60301 M.tuberculosis gene for 10Sa RNA. Ends changed since first submission (-239 nt).;gbkey=misc_RNA;gene=ssr;product=10Sa RNA
AL123456.3	EMBL	exon	3467967	3468334	.	-	.	ID=exon-ssr-1;Parent=rna-ssr;Note=ssr%2C match to EM_BA:MT10SARNA X60301 M.tuberculosis gene for 10Sa RNA. Ends changed since first submission (-239 nt).;gbkey=misc_RNA;gene=ssr;product=10Sa RNA
AL123456.3	EMBL	gene	3468413	3469264	.	-	.	ID=gene-Rv3099c;Name=Rv3099c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3099c
AL123456.3	EMBL	CDS	3468413	3469264	.	-	0	ID=cds-CCP45909.1;Parent=gene-Rv3099c;Dbxref=EnsemblGenomes-Gn:Rv3099c,EnsemblGenomes-Tr:CCP45909,GOA:O05777,InterPro:IPR010872,InterPro:IPR017517,InterPro:IPR024344,InterPro:IPR027369,UniProtKB/TrEMBL:O05777,NCBI_GP:CCP45909.1;Name=CCP45909.1;Note=Rv3099c%2C (MTCY164.10c)%2C len: 283 aa. Conserved protein%2C some similarity with hypothetical proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor (274 aa)%2CFASTA scores: opt: 384%2C E(): 1.8e-17%2C (32.7%25 identity in 269 aa overlap)%3B and P71606|Y036_MYCTU|Rv0036c from Mycobacterium tuberculosis strain H37Rv (257 aa)%2C FASTA scores: opt: 179%2C E(): 0.00024%2C (25.85%25 identity in 205 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3099c;product=Conserved protein;protein_id=CCP45909.1;transl_table=11
AL123456.3	EMBL	gene	3469301	3469783	.	-	.	ID=gene-Rv3100c;Name=smpB;gbkey=Gene;gene=smpB;gene_biotype=protein_coding;locus_tag=Rv3100c
AL123456.3	EMBL	CDS	3469301	3469783	.	-	0	ID=cds-CCP45910.1;Parent=gene-Rv3100c;Dbxref=EnsemblGenomes-Gn:Rv3100c,EnsemblGenomes-Tr:CCP45910,GOA:P9WGD3,InterPro:IPR000037,InterPro:IPR020081,InterPro:IPR023620,NCBI_GP:CCP45910.1;Name=CCP45910.1;Note=Rv3100c%2C (MTCY164.11c)%2C len: 160 aa. Probable smpB%2Csmall protein b related to several bacterial small protein b homologs e.g. O32881|SSRP_MYCLE|ML0671|MLCB1779.19c from Mycobacterium leprae (160 aa)%2C FASTA scores: opt: 914%2C E(): 1.1e-52%2C (84.9%25 identity in 159 aa overlap)%3B Q9L1S9|SMPB from Streptomyces coelicolor (159 aa)%2C FASTA scores: opt: 568%2C E(): 3.3e-30%2C (55.15%25 identity in 145 aa overlap)%3B O32230|SSRP_BACSU from Bacillus subtilis (156 aa)%2C FASTA scores: opt: 511%2C E(): 1.7e-26%2C (47.05%25 identity in 153 aa overlap)%3B etc. Belongs to the SSRP family. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=smpB;locus_tag=Rv3100c;product=Probable SSRA-binding protein SmpB;protein_id=CCP45910.1;transl_table=11
AL123456.3	EMBL	gene	3469786	3470679	.	-	.	ID=gene-Rv3101c;Name=ftsX;gbkey=Gene;gene=ftsX;gene_biotype=protein_coding;locus_tag=Rv3101c
AL123456.3	EMBL	CDS	3469786	3470679	.	-	0	ID=cds-CCP45911.1;Parent=gene-Rv3101c;Dbxref=EnsemblGenomes-Gn:Rv3101c,EnsemblGenomes-Tr:CCP45911,GOA:P9WG19,InterPro:IPR003838,InterPro:IPR004513,PDB:4N8N,PDB:4N8O,NCBI_GP:CCP45911.1;Name=CCP45911.1;Note=Rv3101c%2C (MTCY164.12c)%2C len: 297 aa. Putative ftsX%2Ccell division protein%2C septation component transport integral membrane protein ABC transporter (see citations below)%2C equivalent to O32882|FTSX_MYCLE|ML0670|MLCB1779.20c cell division protein from Mycobacterium leprae (297 aa)%2CFASTA scores: opt: 1597%2C E(): 9.2e-93%2C (80.8%25 identity in 297 aa overlap)%3B and similar to others e.g. Q9L1S7|SCE59.27c from Streptomyces coelicolor (305 aa)%2CFASTA scores: opt: 585%2C E(): 1.9e-29%2C (34.55%25 identity in 304 aa overlap)%3B O34876|FTSX_BACSU from Bacillus subtilis (296 aa)%2C FASTA scores: opt: 318%2C E(): 9.1e-13%2C (24.65%25 identity in 300 aa overlap)%3B Q9K6X3|FTSX|BH3601 from Bacillus halodurans (298 aa)%2C FASTA scores: opt: 290%2C E(): 5.2e-11%2C (22.75%25 identity in 299 aa overlap)%3B etc. Belongs to the FTSX family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ftsX;locus_tag=Rv3101c;product=Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter);protein_id=CCP45911.1;transl_table=11
AL123456.3	EMBL	gene	3470680	3471369	.	-	.	ID=gene-Rv3102c;Name=ftsE;gbkey=Gene;gene=ftsE;gene_biotype=protein_coding;locus_tag=Rv3102c
AL123456.3	EMBL	CDS	3470680	3471369	.	-	0	ID=cds-CCP45912.1;Parent=gene-Rv3102c;Dbxref=EnsemblGenomes-Gn:Rv3102c,EnsemblGenomes-Tr:CCP45912,GOA:O05779,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR005286,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O05779,NCBI_GP:CCP45912.1;Name=CCP45912.1;Note=Rv3102c%2C (MTCY164.13_2c)%2C len: 229 aa. Putative ftsE%2C cell division protein%2C septation component transport ATP-binding protein ABC transporter (see citations below)%2Cequivalent to O32883|FTSE|ML0669 cell division ATP-binding protein from Mycobacterium leprae (229 aa)%2C FASTA scores: opt: 1384%2C E(): 2.4e-74%2C (91.7%25 identity in 229 aa overlap)%3B and similar to Q9L1S6|FTSE from Streptomyces coelicolor (229 aa)%2C FASTA scores: opt: 914%2C E(): 8.7e-47%2C(62.85%25 identity in 226 aa overlap)%3B Q9A0S4|FTSE|SPY0644 from Streptococcus pyogenes (230 aa)%2C FASTA scores: opt: 866%2C E(): 5.7e-44%2C (57.9%25 identity in 228 aa overlap)%3B Q9CGX0|FTSE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (230 aa)%2C FASTA scores: opt: 792%2CE(): 1.3e-39%2C (52.2%25 identity in 228 aa overlap)%3B etc. Other relatives from Mycobacterium tuberculosis include: MTCY253.24%3B MTCY16B7.10%3B MTCY9C4.04c%3B MTCY50.01%3B MTCY05A6.09c%3B MTCY04C12.31. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and ABC transporters family signature (PS00211). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ftsE;inference=protein motif:PROSITE:PS00211;locus_tag=Rv3102c;product=Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter);protein_id=CCP45912.1;transl_table=11
AL123456.3	EMBL	gene	3471413	3471850	.	-	.	ID=gene-Rv3103c;Name=Rv3103c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3103c
AL123456.3	EMBL	CDS	3471413	3471850	.	-	0	ID=cds-CCP45913.1;Parent=gene-Rv3103c;Dbxref=EnsemblGenomes-Gn:Rv3103c,EnsemblGenomes-Tr:CCP45913,GOA:O05780,UniProtKB/TrEMBL:O05780,NCBI_GP:CCP45913.1;Name=CCP45913.1;Note=Rv3103c%2C (MTCY164.13c)%2C len: 145 aa. Hypothetical unknown pro-rich protein%2C with some similarity to Proline-rich proteins e.g. Q39789 proline-rich cell wall protein from Gossypium hirsutum (Upland cotton) (214 aa)%2CFASTA scores: opt: 267%2C E(): 0.00014%2C (40%25 identity in 110 aa overlap). Equivalent to AAK47525 from M. tuberculosis strain CDC1551 (158 aa) but shorter 13 aa.;gbkey=CDS;locus_tag=Rv3103c;product=Hypothetical proline-rich protein;protein_id=CCP45913.1;transl_table=11
AL123456.3	EMBL	gene	3471852	3472778	.	-	.	ID=gene-Rv3104c;Name=Rv3104c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3104c
AL123456.3	EMBL	CDS	3471852	3472778	.	-	0	ID=cds-CCP45914.1;Parent=gene-Rv3104c;Dbxref=EnsemblGenomes-Gn:Rv3104c,EnsemblGenomes-Tr:CCP45914,GOA:O05781,InterPro:IPR006685,InterPro:IPR010920,InterPro:IPR011014,InterPro:IPR011066,UniProtKB/TrEMBL:O05781,NCBI_GP:CCP45914.1;Name=CCP45914.1;Note=Rv3104c%2C (MTCY164.14c)%2C len: 308 aa. Possible conserved transmembrane protein%2C with some similarity to hypthetical proteins e.g. Q9L1X9|SC8E4A.26 putative membrane protein from Streptomyces coelicolor (408 aa)%2CFASTA scores: opt: 514%2C E(): 4.3e-25%2C (35.2%25 identity in 287 aa overlap)%3B Q9XA89|CF43A.26c hypothetical 36.1 KDA protein from Streptomyces coelicolor (333 aa)%2C FASTA scores: opt: 482%2C E(): 3.7e-23%2C (34.9%25 identity in 301 aa overlap)%3B Q55987|SLR0765 hypothetical 68.9 KDA protein from Synechocystis sp. strain PCC 6803 (617 aa)%2C FASTA scores: opt: 429%2C E(): 1.3e-19%2C (30.6%25 identity in 278 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3104c;product=Possible conserved transmembrane protein;protein_id=CCP45914.1;transl_table=11
AL123456.3	EMBL	gene	3472768	3473904	.	-	.	ID=gene-Rv3105c;Name=prfB;gbkey=Gene;gene=prfB;gene_biotype=protein_coding;locus_tag=Rv3105c
AL123456.3	EMBL	CDS	3472768	3473904	.	-	0	ID=cds-CCP45915.1;Parent=gene-Rv3105c;Dbxref=EnsemblGenomes-Gn:Rv3105c,EnsemblGenomes-Tr:CCP45915,GOA:P9WHG1,InterPro:IPR000352,InterPro:IPR004374,InterPro:IPR005139,InterPro:IPR014720,InterPro:IPR020853,NCBI_GP:CCP45915.1;Name=CCP45915.1;Note=Rv3105c%2C (MTCY164.15c)%2C len: 378 aa. Probable prfB%2Cpeptide chain release factor 2%2C equivalent to O32885|RF2_MYCLE|ML0667|MLCB1779.24c from Mycobacterium leprae%2C FASTA scores: opt: 2197%2C E(): 1.8e-126%2C (90.05%25 identity in 372 aa overlap)%3B and also similar to other peptide chain release factors e.g. Q9L1S3|PRFB from Streptomyces coelicolor (368 aa)%2C FASTA scores: opt: 1674%2CE(): 1.2e-94%2C (69.3%25 identity in 365 aa overlap)%3B O67695|RF2_AQUAE|PRFB|AQ_1840 from Aquifex aeolicus (373 aa)%2C FASTA scores: opt: 1082%2C E(): 1.3e-58%2C (44.45%25 identity in 369 aa overlap)%3B P28367|RF2_BACSU from B. subtilis (366 aa)%2C FASTA scores: opt: 1030%2C E(): 1.9e-55%2C(44.0%25 identity in 359 aa overlap)%3B etc. Also related to Q10605|MTCY373.19|RF1_MYCTU|Rv1299|MT1338 peptide chain release factor 1 (rf-1) (357 aa)%2C FASTA scores: opt: 646%2CE(): 1.1e-34%2C (38.6%25 identity in 350 aa overlap). Contains prokaryotic-type class I peptide chain release factors signature (PS00745). Belongs to the prokaryotic and mitochondrial release factors family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=prfB;inference=protein motif:PROSITE:PS00745;locus_tag=Rv3105c;product=Probable peptide chain release factor 2 PrfB (RF-2);protein_id=CCP45915.1;transl_table=11
AL123456.3	EMBL	gene	3474007	3475377	.	+	.	ID=gene-Rv3106;Name=fprA;gbkey=Gene;gene=fprA;gene_biotype=protein_coding;locus_tag=Rv3106
AL123456.3	EMBL	CDS	3474007	3475377	.	+	0	ID=cds-CCP45916.1;Parent=gene-Rv3106;Dbxref=EnsemblGenomes-Gn:Rv3106,EnsemblGenomes-Tr:CCP45916,GOA:P9WIQ3,InterPro:IPR016040,InterPro:IPR021163,PDB:1LQT,PDB:1LQU,PDB:2C7G,NCBI_GP:CCP45916.1;Name=CCP45916.1;Note=Rv3106%2C (MTCY164.16)%2C len: 456 aa. FprA%2CNADPH:adrenodoxin oxidoreductase (NADPH-ferredoxin reductase) (see citations below)%2C equivalent to O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae (456 aa)%2C FASTA scores: opt: 2505%2C E(): 1.2e-142%2C (81%2C05%25 identity in 459 aa overlap)%3B also similar to other NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from Deinococcus radiodurans (479 aa)%2C FASTA scores: opt: 1331%2CE(): 2.6e-72%2C (48.9%25 identity in 454 aa overlap)%3B Q9RK35|SCF15.02 from Streptomyces coelicolor (454 aa)%2CFASTA scores: opt: 1102%2C E(): 1.3e-58%2C (41.35%25 identity in 462 aa overlap)%3B P82861 from Salvelinus fontinalis (Brook trout) (498 aa)%2C FASTA scores: opt: 827%2C E(): 4e-42%2C (41.3%25 identity in 460 aa overlap)%3B Q9V3T9|ADRO_DROME from Drosophila melanogaster (Fruit fly) (466 aa)%2C FASTA scores: opt: 790%2C E(): 6.3e-40%2C (39.45%25 identity in 459 aa overlap)%3B etc. Also similar to Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium tuberculosis strain H37Rv (575 aa)%2C FASTA scores: opt: 894%2CE(): 4.4e-46%2C (42.05%25 identity in 459 aa overlap). Cofactor: FAD;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fprA;locus_tag=Rv3106;product=NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase);protein_id=CCP45916.1;transl_table=11
AL123456.3	EMBL	gene	3475378	3476961	.	-	.	ID=gene-Rv3107c;Name=agpS;gbkey=Gene;gene=agpS;gene_biotype=protein_coding;locus_tag=Rv3107c
AL123456.3	EMBL	CDS	3475378	3476961	.	-	0	ID=cds-CCP45917.1;Parent=gene-Rv3107c;Dbxref=EnsemblGenomes-Gn:Rv3107c,EnsemblGenomes-Tr:CCP45917,GOA:O05784,InterPro:IPR004113,InterPro:IPR006094,InterPro:IPR016164,InterPro:IPR016166,InterPro:IPR016167,InterPro:IPR016169,InterPro:IPR016171,InterPro:IPR025650,UniProtKB/TrEMBL:O05784,NCBI_GP:CCP45917.1;Name=CCP45917.1;Note=Rv3107c%2C (MTCY164.17c)%2C len: 527 aa. Possible agpS%2Calkyl-dihydroxyacetonephosphate synthase%2C similar to others and some various enzymes e.g. AAK46595|MT2311 putative alkyl-dihydroxyacetonephosphate synthase from Mycobacterium tuberculosis strain CDC1551 (529 aa)%2C FASTA scores: opt: 1052%2C E(): 2.1e-58%2C (37.1%25 identity in 542 aa overlap)%3B Q9RJ97|SCF91.28c putative flavoprotein from Streptomyces coelicolor (530 aa)%2C FASTA scores: opt: 972%2C E(): 2.2e-53%2C(36.2%25 identity in 544 aa overlap)%3B O96759|ADAS_DICDI alkyldihydroxyacetonephosphate synthase from Dictyostelium discoideum (Slime mold) (611 aa)%2C FASTA scores: opt: 617%2CE(): 4.5e-31%2C (33.95%25 identity in 480 aa overlap)%3B O97157|ADAS_TRYBB alkyldihydroxyacetonephosphate synthase from Trypanosoma brucei (613 aa)%2C FASTA scores: opt: 567%2CE(): 6.2e-28%2C (29.15%25 identity in 521 aa overlap)%3B etc. Also similar to O53525|Rv2251|MTV022.01 hypothetical 49.8 KDA protein from Mycobacterium tuberculosis strain H37Rv (475 aa)%2C FASTA scores: opt: 1019%2C E(): 2.3e-56%2C (38.6%25 identity in 487 aa overlap). Belongs to the FAD-binding oxidoreductase/transferase family 4. Cofactor: FAD (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=agpS;locus_tag=Rv3107c;product=Possible alkyldihydroxyacetonephosphate synthase AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate synthase);protein_id=CCP45917.1;transl_table=11
AL123456.3	EMBL	gene	3477060	3477500	.	+	.	ID=gene-Rv3108;Name=Rv3108;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3108
AL123456.3	EMBL	CDS	3477060	3477500	.	+	0	ID=cds-CCP45918.1;Parent=gene-Rv3108;Dbxref=EnsemblGenomes-Gn:Rv3108,EnsemblGenomes-Tr:CCP45918,UniProtKB/TrEMBL:O05785,NCBI_GP:CCP45918.1;Name=CCP45918.1;Note=Rv3108%2C (MTCY164.18)%2C len: 146 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv3108;product=Hypothetical protein;protein_id=CCP45918.1;transl_table=11
AL123456.3	EMBL	gene	3477649	3478728	.	+	.	ID=gene-Rv3109;Name=moaA1;gbkey=Gene;gene=moaA1;gene_biotype=protein_coding;gene_synonym=moaA;locus_tag=Rv3109
AL123456.3	EMBL	CDS	3477649	3478728	.	+	0	ID=cds-CCP45919.1;Parent=gene-Rv3109;Dbxref=EnsemblGenomes-Gn:Rv3109,EnsemblGenomes-Tr:CCP45919,GOA:P9WJS3,InterPro:IPR000385,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR010505,InterPro:IPR013483,InterPro:IPR013785,NCBI_GP:CCP45919.1;Name=CCP45919.1;Note=Rv3109%2C (MTCY164.19)%2C len: 359 aa. Probable moaA1%2Cmolybdenum cofactor biosynthesis protein%2C highly similar to others e.g. P39757|MOAA_BACSU|NARA|NARAB from Bacillus subtilis (341 aa)%2C FASTA scores: opt: 810%2C E(): 6.2e-44%2C(39.75%25 identity in 327 aa overlap)%3B O67929|MOAA_AQUAE|AQ_2183 from Aquifex aeolicus (320 aa)%2CFASTA scores: opt: 794%2C E(): 6e-43%2C (40.55%25 identity in 323 aa overlap)%3B Q9ZIM6|MOAA_STACA from Staphylococcus carnosus (340 aa)%2C FASTA scores: opt: 783%2C E(): 3.2e-42%2C (38.65%25 identity in 326 aa overlap)%3B etc. Also highly similar to O53143|MOAA3|MOA3_MYCTU|MT3427 molybdenum cofactor biosynthesis protein A 3 from Mycobacterium tuberculosis strain F4 (378 aa)%2C FASTA scores: opt: 1762%2C E(): 4.7e-104%2C(74.3%25 identity in 350 aa overlap)%3B and similar to O53881|MOA2_MYCTU|MOAA2|Rv0869c|MT0892|MTV043.62 molybdenum cofactor biosynthesis protein A 2 from Mycobacterium tuberculosis strain H37Rv (360 aa)%2C FASTA scores: opt: 657%2CE(): 3e-34%2C (36.55%25 identity in 309 aa overlap). Belongs to the MoaA / NifB / PqqE family. Note that previously known as moaA. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moaA1;locus_tag=Rv3109;product=Probable molybdenum cofactor biosynthesis protein A MoaA1;protein_id=CCP45919.1;transl_table=11
AL123456.3	EMBL	gene	3478779	3479174	.	+	.	ID=gene-Rv3110;Name=moaB1;gbkey=Gene;gene=moaB1;gene_biotype=protein_coding;gene_synonym=moaB;locus_tag=Rv3110
AL123456.3	EMBL	CDS	3478779	3479174	.	+	0	ID=cds-CCP45920.1;Parent=gene-Rv3110;Dbxref=EnsemblGenomes-Gn:Rv3110,EnsemblGenomes-Tr:CCP45920,GOA:Q6MX13,InterPro:IPR001533,UniProtKB/TrEMBL:Q6MX13,NCBI_GP:CCP45920.1;Name=CCP45920.1;Note=Rv3110%2C (MTCY164.20)%2C len: 131 aa. Probable moaB1%2Cpterin-4-alpha-carbinolamine dehydratase%2C similar to others e.g. P73790|SSL2296 from Synechocystis sp. strain PCC 6803 (96 aa)%2C FASTA scores: opt: 195%2C E(): 6.2e-07%2C (35.4%25 identity in 96 aa overlap)%3B Q9PAB4|PHS_XYLFA|XF2604 from Xylella fastidiosa (116 aa)%2C FASTA scores: opt: 187%2C E(): 2.6e-06%2C (36.25%25 identity in 102 aa overlap)%3B AAK42360|Q97WM6|PHS_SULSO|SSO2187 from Sulfolobus solfataricus (114 aa)%2C FASTA scores: opt: 177%2C E(): 1.3e-05%2C (34.6%25 identity in 78 aa overlap)%3B etc. Also highly similar to AAK47768|MT3426 pterin-4-alpha-carbinolamine dehydratase from Mycobacterium tuberculosis CDC1551 (124 aa)%2C FASTA scores: opt: 383%2C E(): 7.7e-20%2C (50.0%25 identity in 110 aa overlap). Belongs to the pterin-4-alpha-carbinolamine dehydratase family. Note that previously known as moaB. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=moaB1;locus_tag=Rv3110;product=Probable pterin-4-alpha-carbinolamine dehydratase MoaB1 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD);protein_id=CCP45920.1;transl_table=11
AL123456.3	EMBL	gene	3479171	3479683	.	+	.	ID=gene-Rv3111;Name=moaC1;gbkey=Gene;gene=moaC1;gene_biotype=protein_coding;gene_synonym=moaC;locus_tag=Rv3111
AL123456.3	EMBL	CDS	3479171	3479683	.	+	0	ID=cds-CCP45921.1;Parent=gene-Rv3111;Dbxref=EnsemblGenomes-Gn:Rv3111,EnsemblGenomes-Tr:CCP45921,GOA:P9WJR9,InterPro:IPR002820,InterPro:IPR023045,InterPro:IPR023046,NCBI_GP:CCP45921.1;Name=CCP45921.1;Note=Rv3111%2C (MTCY164.21)%2C len: 170 aa. Probable moaC1%2Cmolybdopterin cofactor biosynthesis protein%2C highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa)%2C FASTA scores: opt: 576%2C E(): 2.2e-29%2C(62.1%25 identity in 153 aa overlap)%3B Q9ZFA6|MOAC from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (159 aa)%2C FASTA scores: opt: 541%2C E(): 3.4e-27%2C (59.85%25 identity in 157 aa overlap)%3B BAB48171|MLR0616 from Rhizobium loti (Mesorhizobium loti) (160 aa)%2C FASTA scores: opt: 531%2C E(): 1.5e-26%2C (58.75%25 identity in 160 aa overlap)%3B P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa)%2C FASTA scores: opt: 527%2C E(): 2.6e-26%2C (58.5%25 identity in 159 aa overlap)%3B etc. Also highly similar to O53376|MOAC3|Rv3324c|MTV016.24c putative molybdenum cofactor biosynthesis protein C 3 from Mycobacterium tuberculosis (177 aa)%2C FASTA scores: opt: 738%2C E(): 1.7e-39%2C (71.5%25 identity in 165 aa overlap)%3B AAK47767|MT3425 molybdopterin cofactor biosynthesis protein C from Mycobacterium tuberculosis strain CDC1551 (184 aa)%2CFASTA scores: opt: 734%2C E(): 3.1e-39%2C (71.8%25 identity in 163 aa overlap)%3B and Rv0864|MOAC2|MTV043.57 putative molybdenum cofactor biosynthesis protein C 2 (167 aa). Note that previously known as moaC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moaC1;locus_tag=Rv3111;product=Probable molybdenum cofactor biosynthesis protein C MoaC1;protein_id=CCP45921.1;transl_table=11
AL123456.3	EMBL	gene	3479700	3479951	.	+	.	ID=gene-Rv3112;Name=moaD1;gbkey=Gene;gene=moaD1;gene_biotype=protein_coding;gene_synonym=moaD;locus_tag=Rv3112
AL123456.3	EMBL	CDS	3479700	3479951	.	+	0	ID=cds-CCP45922.1;Parent=gene-Rv3112;Dbxref=EnsemblGenomes-Gn:Rv3112,EnsemblGenomes-Tr:CCP45922,GOA:L7N6B4,InterPro:IPR003749,InterPro:IPR010034,InterPro:IPR012675,InterPro:IPR016155,UniProtKB/TrEMBL:L7N6B4,NCBI_GP:CCP45922.1;Name=CCP45922.1;Note=Rv3112%2C (MTCY164.22)%2C len: 83 aa. Probable moaD1%2Cmolybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1))%2C similar to others e.g. Q9HJF0|TA1019 from Thermoplasma acidophilum (85 aa)%2C FASTA scores: opt: 144%2C E(): 0.0012%2C (31.7%25 identity in 82 aa overlap)%3B BAB59710|TVG0556526 from Thermoplasma volcanium (90 aa)%2C FASTA scores: opt: 144%2C E(): 0.0012%2C (31.7%25 identity in 82 aa overlap)%3B P30748|MOAD_ECOLI|CHLA4|CHLM|B0784 from Escherichia coli strain K12 (81 aa)%2C FASTA scores: opt: 116%2C E(): 0.11%2C(36.9%25 identity in 84 aa overlap)%3B etc. N-terminus also highly similar to to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE fusion protein from Mycobacterium tuberculosis (221 aa)%2C FASTA scores: opt: 333%2C E(): 2e-16%2C (65.05%25 identity in 83 aa overlap)%3B and some similarity with Rv0868c|MTV043.61c|MOAD2 putative molybdenum cofactor biosynthesis protein D 2 (92 aa). Note that previously known as moaD. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=moaD1;locus_tag=Rv3112;product=Probable molybdenum cofactor biosynthesis protein D MoaD1 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor%2C subunit 1);protein_id=CCP45922.1;transl_table=11
AL123456.3	EMBL	gene	3480074	3480742	.	+	.	ID=gene-Rv3113;Name=Rv3113;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3113
AL123456.3	EMBL	CDS	3480074	3480742	.	+	0	ID=cds-CCP45923.1;Parent=gene-Rv3113;Dbxref=EnsemblGenomes-Gn:Rv3113,EnsemblGenomes-Tr:CCP45923,GOA:O05790,InterPro:IPR006439,InterPro:IPR023214,UniProtKB/TrEMBL:O05790,NCBI_GP:CCP45923.1;Name=CCP45923.1;Note=Rv3113%2C (MTCY164.23)%2C len: 222 aa. Possible phosphatase%2C with weak similarity to other phosphatases e.g. Q9KYY0|SCE33.02c from Streptomyces coelicolor (223 aa)%2C FASTA scores: opt: 368%2C E(): 1.2e-16%2C (32.9%25 identity in 222 aa overlap)%3B and Q55039|GPH_SYNP7|CBBZ phosphoglycolate phosphatase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (212 aa)%2C FASTA scores: opt: 176%2C E(): 0.00025%2C (24.7%25 identity in 182 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3113;product=Possible phosphatase;protein_id=CCP45923.1;transl_table=11
AL123456.3	EMBL	gene	3480759	3481289	.	+	.	ID=gene-Rv3114;Name=Rv3114;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3114
AL123456.3	EMBL	CDS	3480759	3481289	.	+	0	ID=cds-CCP45924.1;Parent=gene-Rv3114;Dbxref=EnsemblGenomes-Gn:Rv3114,EnsemblGenomes-Tr:CCP45924,GOA:O05791,InterPro:IPR002125,InterPro:IPR016193,UniProtKB/TrEMBL:O05791,NCBI_GP:CCP45924.1;Name=CCP45924.1;Note=Rv3114%2C (MTCY164.24)%2C len: 176 aa. Conserved hypothetical protein%2C with some similarity to Q9F9W7 cytosine deaminase from Bifidobacterium longum (143 aa)%2CFASTA scores: opt: 207%2C E(): 2.2e-07%2C (37.05%25 identity in 108 aa overlap)%3B and Q9RV23|DR1207 cell cycle protein MESJ%2Cputative/cytosine deaminase-related protein from Deinococcus radiodurans (600 aa)%2C FASTA scores: opt: 212%2CE(): 3.5e-07%2C (33.35%25 identity in 177 aa overlap). Equivalent to AAK47536|MT3196 cytidine and deoxycytidylate deaminase family protein from Mycobacterium tuberculosis strain CDC1551 (187 aa) but shorter 11 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3114;product=Conserved hypothetical protein;protein_id=CCP45924.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3481399	3482722	.	+	.	ID=id-AL123456.3:3481399..3482722;Note=IS1081-6%2C len: 1324 nt. Insertion sequence IS1081. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1081-6
AL123456.3	EMBL	repeat_region	3481399	3481413	.	+	.	ID=id-AL123456.3:3481399..3481413;Note=15 bp inverted repeat at left end of IS1081: TCGCGTGATCCTTCG. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3481451	3482698	.	+	.	ID=gene-Rv3115;Name=Rv3115;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3115
AL123456.3	EMBL	CDS	3481451	3482698	.	+	0	ID=cds-CCP45925.1;Parent=gene-Rv3115;Dbxref=EnsemblGenomes-Gn:Rv3115,EnsemblGenomes-Tr:CCP45925,GOA:P96354,InterPro:IPR001207,UniProtKB/TrEMBL:P96354,NCBI_GP:CCP45925.1;Name=CCP45925.1;Note=Rv3115%2C (MTCY164.25)%2C len: 415 aa. Probable IS1081 transposase%2C similar to others. Has transposases%2C mutator family%2C signature (PS01007). Other copies are MTCY10G2.02c%2CMTCY441.35%2C MTCY77.03c. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;inference=protein motif:PROSITE:PS01007;locus_tag=Rv3115;product=Probable transposase;protein_id=CCP45925.1;transl_table=11
AL123456.3	EMBL	repeat_region	3482708	3482722	.	-	.	ID=id-AL123456.3:3482708..3482722;Note=15 bp inverted repeat at right end of IS1081: TCGCGTGATCCTTCG. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3482776	3483945	.	+	.	ID=gene-Rv3116;Name=moeB2;gbkey=Gene;gene=moeB2;gene_biotype=protein_coding;gene_synonym=moeB;locus_tag=Rv3116
AL123456.3	EMBL	CDS	3482776	3483945	.	+	0	ID=cds-CCP45926.1;Parent=gene-Rv3116;Dbxref=EnsemblGenomes-Gn:Rv3116,EnsemblGenomes-Tr:CCP45926,GOA:L7N674,InterPro:IPR000594,InterPro:IPR001763,InterPro:IPR007901,InterPro:IPR009036,InterPro:IPR016040,UniProtKB/TrEMBL:L7N674,NCBI_GP:CCP45926.1;Name=CCP45926.1;Note=Rv3116%2C (MTCY164.26)%2C len: 389 aa. Probable moeB2%2Cmolybdopterin cofactor biosynthesis protein%2C equivalent to Q9CCG8|MOEZ|ML0817 protein probably involved in molybdopterin biosynthesis from Mycobacterium leprae (395 aa)%2C FASTA scores: opt: 1433%2C E(): 8e-80%2C (57.8%25 identity in 384 aa overlap). Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 putative sulfurylase from Streptomyces coelicolor (392 aa)%2C FASTA scores: opt: 1562%2C E(): 1.1e-87%2C (58.15%25 identity in 380 aa overlap)%3B Q9XC37|PDTORFF MOEB-like protein (putative sulfurylase) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa)%2C FASTA scores: opt: 1311%2C E(): 2.1e-72%2C (52.4%25 identity in 395 aa overlap)%3B O54307|MPT|MOEB MPT-synthase sulfurylase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa)%2C FASTA scores: opt: 1238%2C E(): 5.7e-68%2C (51.4%25 identity in 393 aa overlap)%3B P74344|MOEB|SLL1536 molybdopterin biosynthesis MOEB protein from Synechocystis sp. strain PCC 6803 (392 aa)%2C FASTA scores: opt: 1212%2C E(): 2.2e-66%2C (46.5%25 identity in 398 aa overlap)%3B etc. Also highly similar to O05860|MTCY07D11.20|MOEB1|Rv3206c putative molybdenum cofactor biosynthesis protein from Mycobacterium tuberculosis strain H37Rv (392 aa)%2C FASTA scores: opt: 1445%2C E(): 1.5e-80%2C (56.25%25 identity in 400 aa overlap). Belongs to the HesA /MoeB/ThiF family. Note that previously known as moeB. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=moeB2;locus_tag=Rv3116;product=Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase);protein_id=CCP45926.1;transl_table=11
AL123456.3	EMBL	gene	3483974	3484807	.	+	.	ID=gene-Rv3117;Name=cysA3;gbkey=Gene;gene=cysA3;gene_biotype=protein_coding;gene_synonym=sseC3;locus_tag=Rv3117
AL123456.3	EMBL	CDS	3483974	3484807	.	+	0	ID=cds-CCP45927.1;Parent=gene-Rv3117;Dbxref=EnsemblGenomes-Gn:Rv3117,EnsemblGenomes-Tr:CCP45927,GOA:P9WHF9,InterPro:IPR001307,InterPro:IPR001763,PDB:3AAX,PDB:3AAY,PDB:3HWI,NCBI_GP:CCP45927.1;Name=CCP45927.1;Note=Rv3117%2C (MTCY164.27%2C MT3199%2C O05793)%2C len: 277 aa. Probable cysA3 (alternate gene name: sseC3)%2C thiosulfate sulfurtransferase (see Wooff et al.%2C 2002)%2C equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE putative sulfurtransferase thiosulfate from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa)%2C FASTA scores: opt: 1442%2C E(): 1.7e-84%2C (75.55%25 identity in 274 aa overlap)%3B Q9RXT9DR0217|DR0217 from Deinococcus radiodurans (286 aa)%2C FASTA scores: opt: 1046%2CE(): 2.6e-59%2C (53.8%25 identity in 275 aa overlap)%3B Q9HMT7|TSSA|VNG2393G from Halobacterium sp. strain NRC-1 (293 aa)%2C FASTA scores: opt: 1030%2C E(): 2.7e-58%2C (56.1%25 identity in 278 aa overlap)%3B Q9Y8N8|APE2595 from Aeropyrum pernix (218 aa)%2C FASTA scores: opt: 808%2C E(): 2.7e-44%2C(53.5%25 identity in 215 aa overlap)%3B etc. Identical second copy present as Rv0815c|AL022004|MTV043.07c|MT0837|O05793|cysA2 (277 aa) (100.0%25 identity in 277 aa overlap). Also shows some similarity to P96888|THT2_MYCTU|SSEA|Rv3283|MT3382|MTCY71.23 putative thiosulfate sulfurtransferase from Mycobacterium tuberculosis (297 aa)%2C FASTA scores: opt: 955%2C E(): 1.6e-53%2C (50.2%25 identity in 271 aa overlap)%3B and Q59570|THT3_MYCTU|SSEB|Rv2291|MT2348|MTCY339.19c putative thiosulfate sulfurtransferase from Mycobacterium tuberculosis (284 aa)%2C FASTA scores: E(): 1.4e-14%2C (26.7%25 identity in 292 aa overlap). Contains rhodanese active site and C-terminal signatures (PS00380%2C PS00683). Belongs to the rhodanese family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysA3;inference=protein motif:PROSITE:PS00683;locus_tag=Rv3117;product=Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase);protein_id=CCP45927.1;transl_table=11
AL123456.3	EMBL	gene	3484809	3485111	.	+	.	ID=gene-Rv3118;Name=sseC1;gbkey=Gene;gene=sseC1;gene_biotype=protein_coding;gene_synonym=sseC;locus_tag=Rv3118
AL123456.3	EMBL	CDS	3484809	3485111	.	+	0	ID=cds-CCP45928.1;Parent=gene-Rv3118;Dbxref=EnsemblGenomes-Gn:Rv3118,EnsemblGenomes-Tr:CCP45928,InterPro:IPR008969,InterPro:IPR010814,InterPro:IPR014766,NCBI_GP:CCP45928.1;Name=CCP45928.1;Note=Rv3118%2C (MTCY164.28%2C O05794)%2C len: 100 aa. SseC1%2Cconserved hypothetical protein%2C equivalent to Q9CBC7|ML2199 hypothetical protein from Mycobacterium leprae (100 aa)%2CFASTA scores: opt: 545%2C E(): 3.1e-30%2C (84.0%25 identity in 10 aa overlap). Also similar to hypothetical proteins e.g. Q50035 from Saccharopolyspora erythraea (Streptomyces erythraeus) (101 aa)%2C FASTA scores: opt: 345%2C E(): 9.7e-17%2C(57.15%25 identity in 98 aa overlap)%3B and Q9K4H3|SCD66.02 from Streptomyces coelicolor (95 aa)%2C FASTA scores: opt: 249%2C E(): 2.8e-10%2C (48.5%25 identity in 99 aa overlap). Some weak similarity with Q9ZB84|PCAG protocatechuate 3%2C4-dioxygenase alpha-subunit from Pseudomonas marginata (196 aa)%2C FASTA scores: opt: 109%2C E(): 1.4%2C (31.3%25 identity in 83 aa overlap)%3B and other bacterial proteins. Identical second copy present as Rv0814c|AL022004|MTV043.06c|SSEC2 from Mycobacterium tuberculosis (100 aa) (100.0%25 identity in 100 aa overlap). Note that previously known as sseC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=sseC1;locus_tag=Rv3118;product=Conserved hypothetical protein SseC1;protein_id=CCP45928.1;transl_table=11
AL123456.3	EMBL	gene	3485132	3485575	.	+	.	ID=gene-Rv3119;Name=moaE1;gbkey=Gene;gene=moaE1;gene_biotype=protein_coding;gene_synonym=moaE;locus_tag=Rv3119
AL123456.3	EMBL	CDS	3485132	3485575	.	+	0	ID=cds-CCP45929.1;Parent=gene-Rv3119;Dbxref=EnsemblGenomes-Gn:Rv3119,EnsemblGenomes-Tr:CCP45929,GOA:P9WJR3,InterPro:IPR003448,PDB:2WP4,NCBI_GP:CCP45929.1;Name=CCP45929.1;Note=Rv3119%2C (MTCY164.29)%2C len: 147 aa. Probable moaE1%2Cmolybdopterin converting factor E (molybdopterin converting factor (subunit 2))%2C highly similar to others e.g. O31705|MOAE from Bacillus subtilis (157 aa)%2C FASTA scores: opt: 390%2C E(): 8.6e-19%2C (43.95%25 identity in 132 aa overlap)%3B Q9K8I7|MOAE|BH3019 from Bacillus halodurans (156 aa)%2C FASTA scores: opt: 369%2C E(): 2e-17%2C (42.4%25 identity in 132 aa overlap)%3B P30749|MOAE_ECOLI|CHLA5|B0785 from Escherichia coli strain K12 (149 aa)%2C FASTA scores: opt: 312%2C E(): 1.1e-13%2C (38.45%25 identity in 130 aa overlap)%3B etc. Also highly similar (but shorter 74 aa) to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE fusion protein from Mycobacterium tuberculosis (221 aa)%2C FASTA scores: opt: 733%2C E(): 3.9e-41%2C (76.2%25 identity in 143 aa overlap)%3B and highly similar to O53878|MOAE2|Rv0866|MTV043.59 putative molybdopterin synthase large subunit from Mycobacterium tuberculosis (141 aa)%2C FASTA scores: opt: 321%2C E(): 2.6e-14%2C (40.9%25 identity in 132 aa overlap). Note that previously known as moaE. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moaE1;locus_tag=Rv3119;product=Probable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor%2C subunit 2);protein_id=CCP45929.1;transl_table=11
AL123456.3	EMBL	gene	3485572	3486174	.	+	.	ID=gene-Rv3120;Name=Rv3120;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3120
AL123456.3	EMBL	CDS	3485572	3486174	.	+	0	ID=cds-CCP45930.1;Parent=gene-Rv3120;Dbxref=EnsemblGenomes-Gn:Rv3120,EnsemblGenomes-Tr:CCP45930,GOA:O05796,InterPro:IPR029063,UniProtKB/TrEMBL:O05796,NCBI_GP:CCP45930.1;Name=CCP45930.1;Note=Rv3120%2C (MTCY164.30)%2C len: 200 aa. Conserved hypothetical protein%2C with weak similarity to several hypothetical proteins and many N-methyl transferases e.g. Q9X9V1|ORF8 putative methyltransferase from Streptomyces coelicolor A3(2) (208 aa)%2C FASTA scores: opt: 177%2C E(): 0.00011%2C (34.6%25 identity in 130 aa overlap)%3B Q9XA90|SCF43A.25c putative methyltransferase from Streptomyces coelicolor (215 aa)%2C FASTA scores: opt: 147%2CE(): 0.011%2C (31.3%25 identity in 166 aa overlap)%3B BAB52127|MLL5735 probable methyltransferase from Rhizobium loti (Mesorhizobium loti) (247 aa)%2C FASTA scores: opt: 133%2CE(): 0.11%2C (29.75%25 identity in 158 aa overlap). Highly similar to O53374|Rv3322c|MTV016.22c possible methyltransferase from Mycobacterium tuberculosis strain H37Rv (204 aa)%2C FASTA scores: opt: 691%2C E(): 1.1e-38%2C(57.0%25 identity in 200 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3120;product=Conserved hypothetical protein;protein_id=CCP45930.1;transl_table=11
AL123456.3	EMBL	gene	3486509	3487711	.	+	.	ID=gene-Rv3121;Name=cyp141;gbkey=Gene;gene=cyp141;gene_biotype=protein_coding;locus_tag=Rv3121
AL123456.3	EMBL	CDS	3486509	3487711	.	+	0	ID=cds-CCP45931.1;Parent=gene-Rv3121;Dbxref=EnsemblGenomes-Gn:Rv3121,EnsemblGenomes-Tr:CCP45931,GOA:P9WPL7,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,NCBI_GP:CCP45931.1;Name=CCP45931.1;Note=Rv3121%2C (MTCY164.31)%2C len: 400 aa. Probable cyp141%2Ccytochrome P-450 integral membrane protein%2C similar to other cytochrome P450-dependent oxidases e.g. Q9X5P9|CYP107N1 from Streptomyces lavendulae (410 aa)%2CFASTA scores: opt: 825%2C E(): 3.1e-42%2C (33.35%25 identity in 393 aa overlap)%3B Q59819|OLEP|CYP107D1 from Streptomyces antibioticus (407 aa)%2C FASTA scores: opt: 812%2C E(): 1.9e-41%2C (34.85%25 identity in 396 aa overlap)%3B O32460|CYP107M1 from Actinomadura hibisca (411 aa)%2C FASTA scores: opt: 713%2C E(): 1.6e-35%2C (31.05%25 identity in 396 aa overlap)%3B P55544|CPXP_RHISN|CYP112A|Y4LD from Rhizobium sp. strain NGR234 (400 aa)%2C FASTA scores: opt: 688%2C E(): 5.1e-34%2C (33.0%25 identity in 406 aa overlap)%3B etc. Also similar to MTCY339.44c%2C MTCY369.22%2C MTCY50.26%2C MTCY03C7.11%2CMTCY339.34c%2C MTCY339.42%2C MTCY369.11c. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). Belongs to the cytochrome P450 family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;gene=cyp141;inference=protein motif:PROSITE:PS00086;locus_tag=Rv3121;product=Probable cytochrome P450 141 Cyp141;protein_id=CCP45931.1;transl_table=11
AL123456.3	EMBL	gene	3488089	3488559	.	+	.	ID=gene-Rv3122;Name=Rv3122;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3122
AL123456.3	EMBL	CDS	3488089	3488559	.	+	0	ID=cds-CCP45932.1;Parent=gene-Rv3122;Dbxref=EnsemblGenomes-Gn:Rv3122,EnsemblGenomes-Tr:CCP45932,UniProtKB/TrEMBL:O07033,NCBI_GP:CCP45932.1;Name=CCP45932.1;Note=Rv3122%2C (MTCY164.32)%2C len: 156 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv3122;product=Hypothetical protein;protein_id=CCP45932.1;transl_table=11
AL123456.3	EMBL	gene	3488569	3489063	.	+	.	ID=gene-Rv3123;Name=Rv3123;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3123
AL123456.3	EMBL	CDS	3488569	3489063	.	+	0	ID=cds-CCP45933.1;Parent=gene-Rv3123;Dbxref=EnsemblGenomes-Gn:Rv3123,EnsemblGenomes-Tr:CCP45933,UniProtKB/TrEMBL:O07034,NCBI_GP:CCP45933.1;Name=CCP45933.1;Note=Rv3123%2C (MTCY164.33)%2C len: 164 aa. Hypothetical unknown protein%2C but N-terminus shares weak similarity with N-terminal part of O93439|CMESO-1 BHLH transcription factor from Gallus gallus (Chicken) (287 aa)%2C FASTA scores: opt: 129%2C E(): 0.81%2C (38.75%25 identity in 80 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3123;product=Hypothetical protein;protein_id=CCP45933.1;transl_table=11
AL123456.3	EMBL	gene	3489506	3490375	.	+	.	ID=gene-Rv3124;Name=moaR1;gbkey=Gene;gene=moaR1;gene_biotype=protein_coding;locus_tag=Rv3124
AL123456.3	EMBL	CDS	3489506	3490375	.	+	0	ID=cds-CCP45934.1;Parent=gene-Rv3124;Dbxref=EnsemblGenomes-Gn:Rv3124,EnsemblGenomes-Tr:CCP45934,GOA:O05797,InterPro:IPR001867,InterPro:IPR005158,InterPro:IPR011990,InterPro:IPR011991,InterPro:IPR016032,NCBI_GP:CCP45934.1;Name=CCP45934.1;Note=Rv3124%2C (MTCY164.34)%2C len: 289 aa. MoaR1%2Ctranscriptional regulatory protein%2C similar to many Streptomyces and Mycobacterium tuberculosis regulatory proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15 from Mycobacterium tuberculosis strain H37Rv (388 aa)%2CFASTA scores: opt: 963%2C E(): 2e-56%2C (55.15%25 identity in 252 aa overlap)%3B O53145 from Mycobacterium tuberculosis (381 aa)%3B P71484|EMBR from Mycobacterium avium (384 aa)%2C FASTA scores: opt: 859%2C E(): 1.5e-49%2C (52.2%25 identity in 249 aa overlap)%3B Q9XCC3|TYLT from Streptomyces fradiae (404 aa)%2CFASTA scores: opt: 462%2C E(): 3.1e-23%2C (35.05%25 identity in 254 aa overlap)%3B Q9XCC4|TYLS from Streptomyces fradiae (277 aa)%2C FASTA scores: opt: 456%2C E(): 5.6e-23%2C (33.45%25 identity in 269 aa overlap)%3B etc. Start chosen by similarity%2Calternative possible (see AAK47548 from Mycobacterium tuberculosis strain CDC1551%2C longer N-terminus (311 aa)). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;gene=moaR1;locus_tag=Rv3124;product=Transcriptional regulatory protein MoaR1;protein_id=CCP45934.1;transl_table=11
AL123456.3	EMBL	gene	3490476	3491651	.	-	.	ID=gene-Rv3125c;Name=PPE49;gbkey=Gene;gene=PPE49;gene_biotype=protein_coding;locus_tag=Rv3125c
AL123456.3	EMBL	CDS	3490476	3491651	.	-	0	ID=cds-CCP45935.1;Parent=gene-Rv3125c;Dbxref=EnsemblGenomes-Gn:Rv3125c,EnsemblGenomes-Tr:CCP45935,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP45935.1;Name=CCP45935.1;Note=Rv3125c%2C (MTCY164.35c)%2C len: 391 aa. PPE49%2C Member of the Mycobacterium tuberculosis PPE family%2C similar to other e.g. P95247|Rv2352c|MTCY98.21c (391 aa)%2C FASTA scores: opt: 1576%2C E(): 3.8e-72%2C (62.55%25 identity in 398 aa overlap)%2C MTCY98.0029c%2C MTCY03A2.22c%2C MTCY10G2.10%2CMTCY02B10.25c%2C MTCI364.08%2C M TCY21C12.09c%2C MTCY48.17. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE49;locus_tag=Rv3125c;product=PPE family protein PPE49;protein_id=CCP45935.1;transl_table=11
AL123456.3	EMBL	gene	3491808	3492122	.	-	.	ID=gene-Rv3126c;Name=Rv3126c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3126c
AL123456.3	EMBL	CDS	3491808	3492122	.	-	0	ID=cds-CCP45936.1;Parent=gene-Rv3126c;Dbxref=EnsemblGenomes-Gn:Rv3126c,EnsemblGenomes-Tr:CCP45936,NCBI_GP:CCP45936.1;Name=CCP45936.1;Note=Rv3126c%2C (MTCY164.36c)%2C unknown%2C len: 104 aa. Hypothetical unknown protein. Shortened version of MTCY164.36c%2C avoiding overlap. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv3126c;product=Hypothetical protein;protein_id=CCP45936.1;transl_table=11
AL123456.3	EMBL	gene	3492147	3493181	.	+	.	ID=gene-Rv3127;Name=Rv3127;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3127
AL123456.3	EMBL	CDS	3492147	3493181	.	+	0	ID=cds-CCP45937.1;Parent=gene-Rv3127;Dbxref=EnsemblGenomes-Gn:Rv3127,EnsemblGenomes-Tr:CCP45937,GOA:P9WL07,InterPro:IPR000415,NCBI_GP:CCP45937.1;Name=CCP45937.1;Note=Rv3127%2C (MTCY164.37)%2C len: 344 aa. Conserved protein%2C highly similar to Mycobacterium tuberculosis protein O53476|Rv2032|MTV018.19 (331 aa)%2C FASTA scores: opt: 1212%2C E(): 6e-69%2C (56.7%25 identity in 321 aa overlap)%2Cand also similar to P95195|MTCY03A2.27c (332 aa)%2C FASTA scores: opt: 521%2C E(): 1.6e-25%3B (35.0%25 identity in 326 aa overlap). Some similarity to C-terminal half of hypothetical Mycobacterium tuberculosis proteins. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3127;product=Conserved protein;protein_id=CCP45937.1;transl_table=11
AL123456.3	EMBL	pseudogene	3493168	3494181	.	-	.	ID=gene-Rv3128c;Name=Rv3128c;gbkey=Gene;gene_biotype=pseudogene;locus_tag=Rv3128c;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	3493168	3494181	.	-	0	ID=cds-Rv3128c;Parent=gene-Rv3128c;Note=Rv3128c%2C (MTCY164.38c)%2C len: 337 aa. Conserved hypothetical protein%2C similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon but is similar throughout its length to Rv2807|MTCY16B7.36c|Z81331 conserved hypothetical protein from Mycobacterium tuberculosis (384 aa)%2C FASTA scores: opt: 954%2C E(): 0%2C (47.2%25 identity in 339 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3128c;product=Conserved hypothetical protein;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	3494660	3494992	.	+	.	ID=gene-Rv3129;Name=Rv3129;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3129
AL123456.3	EMBL	CDS	3494660	3494992	.	+	0	ID=cds-CCP45939.1;Parent=gene-Rv3129;Dbxref=EnsemblGenomes-Gn:Rv3129,EnsemblGenomes-Tr:CCP45939,GOA:P9WL05,InterPro:IPR012349,InterPro:IPR024747,NCBI_GP:CCP45939.1;Name=CCP45939.1;Note=Rv3129%2C (MTCY164.40)%2C len: 110 aa. Conserved hypothetical protein%2C with some similarity to various hypothetical proteins from Streptomyces coelicolor e.g. Q9RI34|SCJ12.26 hypothetical 14.5 KDA protein (137 aa)%2CFASTA scores: opt: 141%2C E(): 0.0016%2C (39.3%25 identity in 84 aa overlap)%3B Q9RI49|SCJ12.09c hypothetical 15.8 KDA protein (146 aa)%2C FASTA scores: opt: 141%2C E(): 0.0017%2C (38.05%25 identity in 92 aa overlap)%3B Q9RJ05|SCJ1.09C possible DNA-binding protein (233 aa)%2C FASTA scores: opt: 140%2C E(): 0.0029%2C (34.85%25 identity in 89 aa overlap)%3B Q9XA48|SCGD3.31c putative branched-chain alpha keto acid dehydrogenase E1 beta subunit (334 aa)%3B etc.;gbkey=CDS;locus_tag=Rv3129;product=Conserved hypothetical protein;protein_id=CCP45939.1;transl_table=11
AL123456.3	EMBL	gene	3494975	3496366	.	-	.	ID=gene-Rv3130c;Name=tgs1;gbkey=Gene;gene=tgs1;gene_biotype=protein_coding;locus_tag=Rv3130c
AL123456.3	EMBL	CDS	3494975	3496366	.	-	0	ID=cds-CCP45940.1;Parent=gene-Rv3130c;Dbxref=EnsemblGenomes-Gn:Rv3130c,EnsemblGenomes-Tr:CCP45940,GOA:P9WKC9,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP45940.1;Name=CCP45940.1;Note=Rv3130c%2C (MTCY03A2.28%2C MTCY164.41c)%2C len: 463 aa. tgs1%2C triacylglycerol synthase (See Daniel et al.%2C 2004%3B Sirakova et al.%2C 2006)%2C similar to several hypothetical Mycobacterium tuberculosis strain H37Rv proteins e.g. O06795|YH60_MYCTU|Rv1760|MTCY28.26 hypothetical 54.1 KDA protein (502 aa)%2C FASTA scores: opt: 586%2C E(): 9.8e-29%2C(28.95%25 identity in 463 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tgs1;locus_tag=Rv3130c;product=Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1;protein_id=CCP45940.1;transl_table=11
AL123456.3	EMBL	gene	3496551	3497549	.	+	.	ID=gene-Rv3131;Name=Rv3131;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3131
AL123456.3	EMBL	CDS	3496551	3497549	.	+	0	ID=cds-CCP45941.1;Parent=gene-Rv3131;Dbxref=EnsemblGenomes-Gn:Rv3131,EnsemblGenomes-Tr:CCP45941,GOA:P9WIZ7,InterPro:IPR000415,InterPro:IPR029479,NCBI_GP:CCP45941.1;Name=CCP45941.1;Note=Rv3131%2C (MTCY03A2.27c)%2C len: 332 aa. Conserved protein%2C similar to other hypothetical bacterial proteins e.g. O53476|Rv2032|MTV018.19 (331 aa)%2C FASTA scores: opt: 568%2C E(): 2.5e-27%2C (36.7%25 identity in 321 aa overlap)%3B O05800|Rv3127|MTCY164.37 (344 aa)%2C FASTA scores: opt: 521%2CE(): 1.9e-24%2C (34.95%25 identity in 326 aa overlap)%3B Q9RI33|SCJ12.27c from Streptomyces coelicolor (335 aa)%2CFASTA scores: opt: 441%2C E(): 1.3e-19%2C (35.75%25 identity in 319 aa overlap)%3B Q9RI44|SCJ12.14 from Streptomyces coelicolor (309 aa)%2C FASTA scores: opt: 328%2C E(): 9.3e-13%2C(27.9%25 identity in 308 aa overlap)%3B Q9CBP5|ML1751 from Mycobacterium leprae (721 aa)%2C FASTA scores: opt: 137%2C E(): 0.78%2C (26.15%25 identity in 298 aa overlap)%3B etc. Equivalent to AAK47555 from Mycobacterium tuberculosis strain CDC1551 but shorter 12 aa. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3131;product=Conserved protein;protein_id=CCP45941.1;transl_table=11
AL123456.3	EMBL	gene	3497529	3499265	.	-	.	ID=gene-Rv3132c;Name=devS;gbkey=Gene;gene=devS;gene_biotype=protein_coding;gene_synonym=dosS;locus_tag=Rv3132c
AL123456.3	EMBL	CDS	3497529	3499265	.	-	0	ID=cds-CCP45942.1;Parent=gene-Rv3132c;Dbxref=EnsemblGenomes-Gn:Rv3132c,EnsemblGenomes-Tr:CCP45942,GOA:P9WGK3,InterPro:IPR003018,InterPro:IPR003594,InterPro:IPR005467,InterPro:IPR011712,InterPro:IPR027035,InterPro:IPR029016,PDB:2W3D,PDB:2W3E,PDB:2W3F,PDB:2W3G,PDB:2W3H,PDB:2Y79,PDB:3ZXO,NCBI_GP:CCP45942.1;Name=CCP45942.1;Note=Rv3132c%2C (MTCY03A2.26)%2C len: 578 aa. DevS (alternate gene name: dosS)%2C membrane-bound two component sensor histidine kinase (see citations below%3B dev for Differentially Expressed in Virulent strain)%2C similar to others two component sensors e.g. Q9RI43|SCJ12.15c putative two-component sensor from Streptomyces coelicolor (585 aa)%2CFASTA scores: opt: 1305%2C E(): 2.5e-69%2C (41.35%25 identity in 573 aa overlap)%3B Q9ZBY4|SCD78.15 putative two component sensor from Streptomyces coelicolor (560 aa)%2C FASTA scores: opt: 1194%2C E(): 8.1e-63%2C (41.05%25 identity in 558 aa overlap)%3B O85371|CPRS two component regulator from Rhodococcus sp (563 aa)%2C FASTA scores: opt: 803%2C E(): 8.3e-40%2C (38.4%25 identity in 552 aa overlap)%3B Q9L094|SCC24.23 putative two-component sensor histidine kinase from Streptomyces coelicolor (similarity only in C-terminus for this one)%3B etc. Also highly similar to mycobacterium O53473|Rv2027c|MTV018.14c putative membrane protein (573 aa)%2C FASTA scores: opt: 2333%2C E(): 7.6e-130%2C(61.45%25 identity in 576 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C 2008). Contains GAF domain that binds heme.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=devS;locus_tag=Rv3132c;product=Two component sensor histidine kinase DevS;protein_id=CCP45942.1;transl_table=11
AL123456.3	EMBL	gene	3499262	3499915	.	-	.	ID=gene-Rv3133c;Name=devR;gbkey=Gene;gene=devR;gene_biotype=protein_coding;gene_synonym=dosR;locus_tag=Rv3133c
AL123456.3	EMBL	CDS	3499262	3499915	.	-	0	ID=cds-CCP45943.1;Parent=gene-Rv3133c;Dbxref=EnsemblGenomes-Gn:Rv3133c,EnsemblGenomes-Tr:CCP45943,GOA:P9WMF9,InterPro:IPR000792,InterPro:IPR001789,InterPro:IPR011006,InterPro:IPR011991,InterPro:IPR016032,PDB:1ZLJ,PDB:1ZLK,PDB:3C3W,PDB:3C57,NCBI_GP:CCP45943.1;Name=CCP45943.1;Note=Rv3133c%2C (MTCY03A2.25)%2C len: 217 aa. DevR (alternate gene name: dosR)%2C two component transcriptional regulator (see Dasgupta et al.%2C 2000%3B dev for Differentially Expressed in Virulent strain)%2C highly similar to several e.g. O85372|CPRR two component regulator from Rhodococcus sp. (212 aa)%2C FASTA scores: opt: 868%2C E(): 6.2e-46%2C (65.05%25 identity in 206 aa overlap)%3B Q9RI42|SCJ12.16c putative LuxR family two-component response regulator from Streptomyces coelicolor (233 aa)%2C FASTA scores: opt: 849%2C E(): 9.7e-45%2C(60.55%25 identity in 218 aa overlap)%3B Q9XA59|SCGD3.19 putative two-component system response transcriptional regulator from Streptomyces coelicolor (218 aa)%2C FASTA scores: opt: 835%2C E(): 6.5e-44%2C (61.55%25 identity in 208 aa overlap)%3B and similar to others. Contains bacterial regulatory proteins%2C LuxR family signature (PS00622) near C-terminus as seen in bvgA%2C comA%2C dctR%2C degU%2C evgA%2C fimZ%2CfixJ%2C gacA%2C glpR%2C narL%2C narP%2C nodW%2C rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15 SD). Belongs to the LuxR/UhpA family of transcriptional regulators. The N-terminal region is similar to that of other regulatory components of sensory transduction systems.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=devR;inference=protein motif:PROSITE:PS00622;locus_tag=Rv3133c;product=Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family);protein_id=CCP45943.1;transl_table=11
AL123456.3	EMBL	gene	3499943	3500749	.	-	.	ID=gene-Rv3134c;Name=Rv3134c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3134c
AL123456.3	EMBL	CDS	3499943	3500749	.	-	0	ID=cds-CCP45944.1;Parent=gene-Rv3134c;Dbxref=EnsemblGenomes-Gn:Rv3134c,EnsemblGenomes-Tr:CCP45944,GOA:P9WFD3,InterPro:IPR006015,InterPro:IPR006016,InterPro:IPR014729,NCBI_GP:CCP45944.1;Name=CCP45944.1;Note=Rv3134c%2C (MTCY03A2.240%2C len: 268 aa. Universal stress protein family protein. Ala-%2C Val- rich (see citations below)%2C related to other hypothetical Mycobacterium tuberculosis proteins e.g. O53474|Rv2028c|MTV018.15c (279 aa)%2C FASTA scores: opt: 562%2CE(): 3.2e-28%2C (40.65%25 identity in 273 aa overlap)%3B O06188|Rv2624c|MTCY01A10.08 (272 aa)%2C FASTA scores: opt: 458%2C E(): 1.1e-21%2C (36.55%25 identity in 271 aa overlap)%3B O53472|R2026c|MTV018.13c (294 aa)%2C FASTA scores: opt: 232%2CE(): 1.9e-07%2C (30.45%25 identity in 276 aa overlap)%3B etc. Shares some similarity with other hypothetical proteins from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c (294 aa)%2CFASTA scores: opt: 207%2C E(): 6.9e-06%2C (28.9%25 identity in 263 aa overlap)%3B Q9K4L5|SC5F8.09 putative stress-inducible protein (312 aa)%2C FASTA scores: opt: 204%2C E(): 1.1e-05%2C(28.4%25 identity in 271 aa overlap)%3B etc. Equivalent to AAK47558|MT3220 Universal stress protein family from Mycobacterium tuberculosis strain CDC1551 (268 aa). Rv3134c seems cotranscribed with devR-devS (see Sherman et al.%2C2001).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3134c;product=Universal stress protein family protein;protein_id=CCP45944.1;transl_table=11
AL123456.3	EMBL	gene	3501334	3501732	.	+	.	ID=gene-Rv3135;Name=PPE50;gbkey=Gene;gene=PPE50;gene_biotype=protein_coding;locus_tag=Rv3135
AL123456.3	EMBL	CDS	3501334	3501732	.	+	0	ID=cds-CCP45945.1;Parent=gene-Rv3135;Dbxref=EnsemblGenomes-Gn:Rv3135,EnsemblGenomes-Tr:CCP45945,GOA:Q6MX07,InterPro:IPR000030,NCBI_GP:CCP45945.1;Name=CCP45945.1;Note=Rv3135%2C (MTCY03A2.23c)%2C len: 132 aa. PPE50%2C Member of the Mycobacterium tuberculosis Ala-%2C Gly-rich PPE family%2C similar to P95190|Rv3136|MTCY03A2.22c (380 aa)%2CFASTA scores: opt: 494%2C E(): 6.7e-25%2C (57.25%25 identity in 131 aa overlap) (next ORF downstream)%2C MTY21C12_9%2CMTCY3C7_24%2C MTCI125_27%2C MTV049_12%2C MTV049_9%2C MTV049_11%2CMTCY274_24 etc.;gbkey=CDS;gene=PPE50;locus_tag=Rv3135;product=PPE family protein PPE50;protein_id=CCP45945.1;transl_table=11
AL123456.3	EMBL	gene	3501794	3502936	.	+	.	ID=gene-Rv3136;Name=PPE51;gbkey=Gene;gene=PPE51;gene_biotype=protein_coding;locus_tag=Rv3136
AL123456.3	EMBL	CDS	3501794	3502936	.	+	0	ID=cds-CCP45946.1;Parent=gene-Rv3136;Dbxref=EnsemblGenomes-Gn:Rv3136,EnsemblGenomes-Tr:CCP45946,GOA:P9WHY3,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP45946.1;Name=CCP45946.1;Note=Rv3136%2C (MTCY03A2.22c)%2C len: 380 aa. PPE51%2C Member of the Mycobacterium tuberculosis Ala-%2C Gly-rich PPE family%2C similar to Q9AGF0|Ov2770c Rv2770c-like protein from M. microti (397 aa)%2C FASTA scores: opt: 917%2C E(): 9e-41%2C(46.15%25 identity in 388 aa overlap)%3B O33312|Rv2770c|MTV002.35c%2C MTV002_36%2C MTCI125_26%2CMTCY10G2_10%2C MTCI364_8%2C MTV049_28%2C MTV049_29%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE51;locus_tag=Rv3136;product=PPE family protein PPE51;protein_id=CCP45946.1;transl_table=11
AL123456.3	EMBL	gene	3502945	3503277	.	-	.	ID=gene-Rv3136A;Name=Rv3136A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3136A
AL123456.3	EMBL	CDS	3502945	3503277	.	-	0	ID=cds-CCP45947.1;Parent=gene-Rv3136A;Dbxref=EnsemblGenomes-Gn:Rv3136A,EnsemblGenomes-Tr:CCP45947,UniProtKB/TrEMBL:I6Y2Q7,NCBI_GP:CCP45947.1;Name=CCP45947.1;Note=Rv3136A%2C len: 110 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3136A;product=Conserved protein;protein_id=CCP45947.1;transl_table=11
AL123456.3	EMBL	gene	3503393	3504175	.	+	.	ID=gene-Rv3137;Name=Rv3137;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3137
AL123456.3	EMBL	CDS	3503393	3504175	.	+	0	ID=cds-CCP45948.1;Parent=gene-Rv3137;Dbxref=EnsemblGenomes-Gn:Rv3137,EnsemblGenomes-Tr:CCP45948,GOA:P95189,InterPro:IPR000760,InterPro:IPR011809,InterPro:IPR020583,NCBI_GP:CCP45948.1;Name=CCP45948.1;Note=Rv3137%2C (MTCY03A2.21c)%2C len: 260 aa. Probable monophosphatase%2C equivalent to O32889|MLCB1779_19|ML0662 putative monophosphatase from Mycobacterium leprae (255 aa)%2C FASTA scores: opt: 1403%2C E(): 1.2e-81%2C (81.8%25 identity in 253 aa overlap). Also similar to Q9K4B1|SC7E4.05c from Streptomyces coelicolor (266 aa)%2C FASTA scores: opt: 969%2CE(): 3.5e-54%2C (57.9%25 identity in 259 aa overlap)%3B Q53743|PUR3 mono-phosphatase from Streptomyces lipmanii (Streptomyces alboniger) (273 aa)%2C FASTA scores: opt: 862%2CE(): 2.1e-47%2C (55.25%25 identity in 257 aa overlap)%3B BAB50023|MLL3039 mono-phosphatase from Rhizobium loti (Mesorhizobium loti) (262 aa)%2C FASTA scores: opt: 448%2C E(): 3.2e-21%2C (31.37%25 identity in 255 aa overlap)%3B etc. Contains inositol monophosphatase family signature 1 (PS00629).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00629;locus_tag=Rv3137;product=Probable monophosphatase;protein_id=CCP45948.1;transl_table=11
AL123456.3	EMBL	gene	3504195	3505283	.	+	.	ID=gene-Rv3138;Name=pflA;gbkey=Gene;gene=pflA;gene_biotype=protein_coding;locus_tag=Rv3138
AL123456.3	EMBL	CDS	3504195	3505283	.	+	0	ID=cds-CCP45949.1;Parent=gene-Rv3138;Dbxref=EnsemblGenomes-Gn:Rv3138,EnsemblGenomes-Tr:CCP45949,GOA:P95188,InterPro:IPR006638,InterPro:IPR007197,InterPro:IPR016431,InterPro:IPR027596,UniProtKB/TrEMBL:P95188,NCBI_GP:CCP45949.1;Name=CCP45949.1;Note=Rv3138%2C (MTCY03A2.20c)%2C len: 362 aa. Probable pflA%2Cpyruvate formate lyase activating protein%2C similar to other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa)%2C FASTA scores: opt: 926%2C E(): 1.1e-52%2C (39.95%25 identity in 343 aa overlap)%3B O27446|MTH1395 from Methanobacterium thermoautotrophicum (335 aa)%2C FASTA scores: opt: 909%2C E(): 1.3e-51%2C (42.2%25 identity in 327 aa overlap)%3B O28939|AF1330 from Archaeoglobus fulgidus (336 aa)%2C FASTA scores: opt: 884%2C E(): 5.6e-50%2C (42.0%25 identity in 319 aa overlap)%3B etc. Also similar to O50099|PH1391 hypothetical 40.2 KDA protein from Pyrococcus horikoshii (348 aa)%2C FASTA scores: opt: 934%2C E(): 3.3e-53%2C (40.5%25 identity in 343 aa overlap)%3B and other hypothetical proteins.;gbkey=CDS;gene=pflA;locus_tag=Rv3138;product=Probable pyruvate formate lyase activating protein PflA (formate acetyltransferase activating enzyme) ([pyruvate formate-lyase] activating enzyme);protein_id=CCP45949.1;transl_table=11
AL123456.3	EMBL	gene	3505363	3506769	.	+	.	ID=gene-Rv3139;Name=fadE24;gbkey=Gene;gene=fadE24;gene_biotype=protein_coding;locus_tag=Rv3139
AL123456.3	EMBL	CDS	3505363	3506769	.	+	0	ID=cds-CCP45950.1;Parent=gene-Rv3139;Dbxref=EnsemblGenomes-Gn:Rv3139,EnsemblGenomes-Tr:CCP45950,GOA:P95187,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P95187,NCBI_GP:CCP45950.1;Name=CCP45950.1;Note=Rv3139%2C (MTCY03A2.19c)%2C len: 468 aa. Probable fadE24%2C acyl-CoA dehydrogenase (1.3.99.-)%2C equivalent to O32890|MLCB1779.30|FADE24|ML0661 putative acyl-CoA dehydrogenase from Mycobacterium leprae (465 aa)%2C FASTA scores: opt: 2587%2C E(): 4e-153%2C (83.6%25 identity in 464 aa overlap). Similar to other e.g. Q9HUH0|PA4995 from Pseudomonas aeruginosa (429 aa)%2C FASTA scores: opt: 1139%2CE(): 2.8e-63%2C (45.3%25 identity in 426 aa overlap)%3B Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa)%2C FASTA scores: opt: 603%2C E(): 4.7e-30%2C (30.3%25 identity in 366 aa overlap)%3B Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa)%2C FASTA scores: opt: 601%2C E(): 6.3e-30%2C (32.25%25 identity in 363 aa overlap)%3B etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073) near C-terminus. Belongs to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE24;inference=protein motif:PROSITE:PS00073;locus_tag=Rv3139;product=Probable acyl-CoA dehydrogenase FadE24;protein_id=CCP45950.1;transl_table=11
AL123456.3	EMBL	gene	3506790	3507995	.	+	.	ID=gene-Rv3140;Name=fadE23;gbkey=Gene;gene=fadE23;gene_biotype=protein_coding;locus_tag=Rv3140
AL123456.3	EMBL	CDS	3506790	3507995	.	+	0	ID=cds-CCP45951.1;Parent=gene-Rv3140;Dbxref=EnsemblGenomes-Gn:Rv3140,EnsemblGenomes-Tr:CCP45951,GOA:P95186,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,UniProtKB/TrEMBL:P95186,NCBI_GP:CCP45951.1;Name=CCP45951.1;Note=Rv3140%2C (MTCY03A2.18c)%2C len: 401 aa. Probable fadE23%2C acyl-CoA dehydrogenase (1.3.99.-) (see citation below)%2C equivalent to O32891|MLCB1779.31|FADE23|ML0660 putative acyl-CoA dehydrogenase from Mycobacterium leprae (400 aa)%2C FASTA scores: opt: 2307%2C E(): 3e-136%2C (89.5%25 identity in 401 aa overlap). Also similar to others e.g. Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa)%2C FASTA scores: opt: 1558%2C E(): 1.2e-89%2C (61.0%25 identity in 400 aa overlap)%3B O31251 from Acinetobacter sp. ADP1 (401 aa)%2CFASTA scores: opt: 1509%2C E(): 1.3e-86%2C (58.2%25 identity in 402 aa overlap)%3B Q9K6D1|ACDA or BH3798 from Bacillus halodurans (380 aa)%2C FASTA scores: opt: 612%2C E(): 8.4e-31%2C(38.2%25 identity in 293 aa overlap)%3B Q9AHX9|FADFX from Pseudomonas putida (375 aa)%2C FASTA scores: opt: 584%2C E(): 4.6e-29%2C (32.7%25 identity in 379 aa overlap)%3B etc. Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE23;locus_tag=Rv3140;product=Probable acyl-CoA dehydrogenase FadE23;protein_id=CCP45951.1;transl_table=11
AL123456.3	EMBL	gene	3508095	3509066	.	+	.	ID=gene-Rv3141;Name=fadB4;gbkey=Gene;gene=fadB4;gene_biotype=protein_coding;locus_tag=Rv3141
AL123456.3	EMBL	CDS	3508095	3509066	.	+	0	ID=cds-CCP45952.1;Parent=gene-Rv3141;Dbxref=EnsemblGenomes-Gn:Rv3141,EnsemblGenomes-Tr:CCP45952,GOA:P95185,InterPro:IPR002085,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,UniProtKB/TrEMBL:P95185,NCBI_GP:CCP45952.1;Name=CCP45952.1;Note=Rv3141%2C (MTCY03A2.17c)%2C len: 323 aa. Probable fadB4%2Cquinone oxidoreductase%2C showing strong similarity to variety of quinone oxidoreductases and domains in polyketide and fatty acid synthases e.g. Q9HTV6|PA5234 probable oxidoreductase from Pseudomonas aeruginosa (325 aa)%2C FASTA scores: opt: 737%2C E(): 1.4e-35%2C (39.65%25 identity in 328 aa overlap)%3B Q9RYQ7|DRA0251 putative NADPH quinone oxidoreductase from Deinococcus radiodurans (336 aa)%2C FASTA scores: opt: 688%2C E(): 1e-32%2C (40.6%25 identity in 325 aa overlap)%3B Q9RVG8|DR1061 putative NADPH quinone oxidoreductase from Deinococcus radiodurans (388 aa)%2C FASTA scores: opt: 559%2C E(): 3.3e-25%2C (36.3%25 identity in 325 aa overlap)%3B BAB49685|MLL2594 probable quinone oxidoreductase from Rhizobium loti (Mesorhizobium loti) (326 aa)%2C FASTA scores: opt: 519%2C E(): 5.9e-23%2C (34.25%25 identity in 330 aa overlap)%3B Q9LXZ4|T5P19_110 quinone reductase-like protein from Arabidopsis thaliana (348 aa)%2C FASTA scores: opt: 517%2CE(): 8.1e-23%2C (33.55%25 identity in 322 aa overlap)%3B etc. Also similar to Q9AA38|CC0770 zinc-containing alcohol dehydrogenase from Caulobacter crescentus (325 aa)%2C FASTA scores: opt: 673%2C E(): 7.2e-32%2C (40.2%25 identity in 326 aa overlap)%3B and Q9ABX4|CC0096 zinc-containing alcohol dehydrogenase from Caulobacter crescentus (332 aa)%2C FASTA scores: opt: 623%2C E(): 5.7e-29%2C (40.7%25 identity in 334 aa overlap). Also resembles Mycobacterium tuberculosis proteins P96826|Rv0149|MTCI5_23%2C MTCY13D12.11%2C MTCY24G1.03%2CMTCY19H9.01. Belongs to the zinc-containing alcohol dehydrogenase family%2C quinone oxidoreductase subfamily. Thought to be differentially expressed within host cells (see Triccas et al.%2C 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadB4;locus_tag=Rv3141;product=Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin);protein_id=CCP45952.1;transl_table=11
AL123456.3	EMBL	gene	3509118	3509546	.	-	.	ID=gene-Rv3142c;Name=Rv3142c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3142c
AL123456.3	EMBL	CDS	3509118	3509546	.	-	0	ID=cds-CCP45953.1;Parent=gene-Rv3142c;Dbxref=EnsemblGenomes-Gn:Rv3142c,EnsemblGenomes-Tr:CCP45953,UniProtKB/TrEMBL:P95184,NCBI_GP:CCP45953.1;Name=CCP45953.1;Note=Rv3142c%2C (MTCY03A2.16)%2C len: 142 aa. Hypothetical unknown protein. Equivalent to AAK47569 from Mycobacterium tuberculosis strain CDC1551 but shorter 33 aa.;gbkey=CDS;locus_tag=Rv3142c;product=Hypothetical protein;protein_id=CCP45953.1;transl_table=11
AL123456.3	EMBL	gene	3509654	3510055	.	+	.	ID=gene-Rv3143;Name=Rv3143;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3143
AL123456.3	EMBL	CDS	3509654	3510055	.	+	0	ID=cds-CCP45954.1;Parent=gene-Rv3143;Dbxref=EnsemblGenomes-Gn:Rv3143,EnsemblGenomes-Tr:CCP45954,GOA:P9WGL7,InterPro:IPR001789,InterPro:IPR011006,NCBI_GP:CCP45954.1;Name=CCP45954.1;Note=Rv3143%2C (MTCY03A2.15c)%2C len: 133 aa. Probable response regulator%2C similar to other sensory transduction regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor (133 aa)%2C FASTA scores: opt: 474%2C E(): 2.8e-24%2C(54.15%25 identity in 120 aa overlap)%3B Q9KZ82|SCE25.04c from Streptomyces coelicolor (225 aa)%2C FASTA scores: opt: 144%2CE(): 0.016%2C (32.3%25 identity in 127 aa overlap)%3B Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa)%2C FASTA scores: opt: 145%2C E(): 0.024%2C (30.65%25 identity in 124 aa overlap). Similar to other regulatory components of sensory transduction systems.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3143;product=Probable response regulator;protein_id=CCP45954.1;transl_table=11
AL123456.3	EMBL	gene	3510088	3511317	.	-	.	ID=gene-Rv3144c;Name=PPE52;gbkey=Gene;gene=PPE52;gene_biotype=protein_coding;locus_tag=Rv3144c
AL123456.3	EMBL	CDS	3510088	3511317	.	-	0	ID=cds-CCP45955.1;Parent=gene-Rv3144c;Dbxref=EnsemblGenomes-Gn:Rv3144c,EnsemblGenomes-Tr:CCP45955,InterPro:IPR000030,UniProtKB/TrEMBL:I6X6H8,NCBI_GP:CCP45955.1;Name=CCP45955.1;Note=Rv3144c%2C (MTCY03A2.14)%2C len: 409 aa. PPE52%2C Member of the Mycobacterium tuberculosis PPE family%2C Gly-%2CAla-rich%2C similar to others e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa)%2C FASTA scores: opt: 1007%2C E(): 5.2e-35%2C (56.2%25 identity in 306 aa overlap)%3B and MTV014_3%2C MTCY6G11_5%2CMTCY98.0034c%2C MTCY31.06c%2C MTCY48.17%2C MTCY98.0029c%2CMTCY03C7.17c%2C etc. Nucleotide position 3510642 in the genome sequence has been corrected%2C T:C resulting in S226G.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE52;locus_tag=Rv3144c;product=PPE family protein PPE52;protein_id=CCP45955.1;transl_table=11
AL123456.3	EMBL	gene	3511682	3512068	.	+	.	ID=gene-Rv3145;Name=nuoA;gbkey=Gene;gene=nuoA;gene_biotype=protein_coding;locus_tag=Rv3145
AL123456.3	EMBL	CDS	3511682	3512068	.	+	0	ID=cds-CCP45956.1;Parent=gene-Rv3145;Dbxref=EnsemblGenomes-Gn:Rv3145,EnsemblGenomes-Tr:CCP45956,GOA:P9WIW7,InterPro:IPR000440,InterPro:IPR023043,NCBI_GP:CCP45956.1;Name=CCP45956.1;Note=Rv3145%2C (MTCY03A2.13c)%2C len: 128 aa. Probable nuoA%2Cintegral membrane NADH dehydrogenase%2C chain A%2C similar to others e.g. Q9XAQ4|NUOA from Streptomyces coelicolor (119 aa)%2C FASTA scores: opt: 405%2C E(): 5.4e-20%2C (68.75%25 identity in 128 aa overlap)%3B Q9RU86|DR1506 from Deinococcus radiodurans (160 aa)%2C FASTA scores: opt: 327%2C E(): 9e-15%2C(40.3%25 identity in 124 aa overlap)%3B BAB47039|NDHC from Triticum aestivum (Wheat)%2C FASTA scores: opt: 273%2C E(): 2.6e-11%2C (38.1%25 identity in 126 aa overlap)%3B etc. Also similar to a NADH-plastoquinone oxidoreductases e.g. P26303|NU3C_WHEAT|NDHC from Triticum aestivum (Wheat) (120 aa)%2C FASTA scores: opt: 273%2C E(): 2.6e-1%2C (38.1%25 identity in 126 aa overlap). Belongs to the complex I subunit 3 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoA;locus_tag=Rv3145;product=Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A);protein_id=CCP45956.1;transl_table=11
AL123456.3	EMBL	gene	3512077	3512631	.	+	.	ID=gene-Rv3146;Name=nuoB;gbkey=Gene;gene=nuoB;gene_biotype=protein_coding;locus_tag=Rv3146
AL123456.3	EMBL	CDS	3512077	3512631	.	+	0	ID=cds-CCP45957.1;Parent=gene-Rv3146;Dbxref=EnsemblGenomes-Gn:Rv3146,EnsemblGenomes-Tr:CCP45957,GOA:P9WJH1,InterPro:IPR006137,InterPro:IPR006138,NCBI_GP:CCP45957.1;Name=CCP45957.1;Note=Rv3146%2C (MTCY03A2.12c)%2C len: 184 aa. Probable nuoB%2CNADH dehydrogenase%2C chain B%2C similar to others e.g. Q9XAQ5|NUOB from Streptomyces coelicolor (184 aa)%2C FASTA scores: opt: 989%2C E(): 1.4e-56%2C (78.25%25 identity in 184 aa overlap)%3B Q56218|NQO6_THETH|NQO6 from Thermus aquaticus (subsp. thermophilus) (181 aa)%2C FASTA scores: opt: 720%2CE(): 2.6e-39%2C (64.45%25 identity in 152 aa overlap)%3B Q9RU87|DR1505 from Deinococcus radiodurans (181 aa)%2C FASTA scores: opt: 719%2C E(): 3e-39%2C (62.6%25 identity in 155 aa overlap)%3B etc. Belongs to the complex I 20 KDA subunit family. May contain an iron-sulfur 4FE-4S cluster.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoB;locus_tag=Rv3146;product=Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B);protein_id=CCP45957.1;transl_table=11
AL123456.3	EMBL	gene	3512628	3513338	.	+	.	ID=gene-Rv3147;Name=nuoC;gbkey=Gene;gene=nuoC;gene_biotype=protein_coding;locus_tag=Rv3147
AL123456.3	EMBL	CDS	3512628	3513338	.	+	0	ID=cds-CCP45958.1;Parent=gene-Rv3147;Dbxref=EnsemblGenomes-Gn:Rv3147,EnsemblGenomes-Tr:CCP45958,GOA:P9WJH3,InterPro:IPR001268,InterPro:IPR010218,NCBI_GP:CCP45958.1;Name=CCP45958.1;Note=Rv3147%2C (MTCY03A2.11c)%2C len: 236 aa. Probable nuoC%2CNADH dehydrogenase%2C chain C%2C similar to others e.g. Q9XAQ6|NUOC from Streptomyces coelicolor (251 aa)%2C FASTA scores: opt: 1113%2C E(): 2.6e-64%2C (67.35%25 identity in 236 aa overlap)%3B Q9A6X2|CC1954 from Caulobacter crescentus (197 aa)%2C FASTA scores: opt: 351%2C E(): 1.6e-15%2C (41.65%25 identity in 132 aa overlap)%3B BAB48757|MLL1369 from Rhizobium loti (Mesorhizobium loti) (201 aa)%2C FASTA scores: opt: 347%2C E(): 3e-15%2C (42.4%25 identity in 132 aa overlap)%3B etc. Also similar to Q9UUU0|NUGM NUGM protein precursor from Yarrowia lipolytica (Candida lipolytica) (281 aa)%2C FASTA scores: opt: 356%2C E(): 1.1e-15%2C (34.55%25 identity in 162 aa overlap). Also similar to MTCY251.05%2C FASTA score: E():4.9e-05. Equivalent to AAK47574 from Mycobacterium tuberculosis strain CDC1551 but longer 26 aa. Belongs to the complex I 30 KDA subunit family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoC;locus_tag=Rv3147;product=Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C);protein_id=CCP45958.1;transl_table=11
AL123456.3	EMBL	gene	3513338	3514660	.	+	.	ID=gene-Rv3148;Name=nuoD;gbkey=Gene;gene=nuoD;gene_biotype=protein_coding;locus_tag=Rv3148
AL123456.3	EMBL	CDS	3513338	3514660	.	+	0	ID=cds-CCP45959.1;Parent=gene-Rv3148;Dbxref=EnsemblGenomes-Gn:Rv3148,EnsemblGenomes-Tr:CCP45959,GOA:P9WJH5,InterPro:IPR001135,InterPro:IPR014029,InterPro:IPR022885,InterPro:IPR029014,NCBI_GP:CCP45959.1;Name=CCP45959.1;Note=Rv3148%2C (MTCY03A2.10c)%2C len: 440 aa. Probable nuoD%2CNADH dehydrogenase%2C chain B%2C similar to others e.g. Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa)%2C FASTA scores: opt: 2198%2C E(): 1e-131%2C (73.9%25 identity in 429 aa overlap)%3B P15689|NUCM_PARTE from Paramecium tetraurelia (400 aa)%2C FASTA scores: opt: 922%2C E(): 5.8e-51%2C (38.5%25 identity in 408 aa overlap)%3B Q9RU89|NUOD_DEIRA|DR1503 from Deinococcus radiodurans (401 aa)%2C FASTA scores: opt: 922%2CE(): 5.8e-51%2C (47.75%25 identity in 404 aa overlap)%3B etc. Equivalent to AAK47575 from Mycobacterium tuberculosis strain CDC1551 but longer 42 aa. Contains helix-turn-helix motif at aa 340-361. Belongs to the complex I 49 KDA subunit family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoD;locus_tag=Rv3148;product=Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D);protein_id=CCP45959.1;transl_table=11
AL123456.3	EMBL	gene	3514657	3515415	.	+	.	ID=gene-Rv3149;Name=nuoE;gbkey=Gene;gene=nuoE;gene_biotype=protein_coding;locus_tag=Rv3149
AL123456.3	EMBL	CDS	3514657	3515415	.	+	0	ID=cds-CCP45960.1;Parent=gene-Rv3149;Dbxref=EnsemblGenomes-Gn:Rv3149,EnsemblGenomes-Tr:CCP45960,GOA:P9WIV5,InterPro:IPR002023,InterPro:IPR012336,NCBI_GP:CCP45960.1;Name=CCP45960.1;Note=Rv3149%2C (MTCY03A2.09c)%2C len: 252 aa. Probable nuoE%2CNADH dehydrogenase%2C chain E%2C similar to others e.g. Q9XAQ8|NUOE from Streptomyces coelicolor (290 aa)%2C FASTA scores: opt: 1002%2C E(): 5.7e-55%2C (69.5%25 identity in 213 aa overlap)%3B P40915|NUHM_NEUCR|NUO-24 from Neurospora crassa (263 aa)%2C FASTA scores: opt: 412%2C E(): 1.9e-18%2C (38055%25 identity in 192 aa overlap)%3B P19234|NUHM_RAT from Rattus norvegicus (Rat) (241 aa)%2C FASTA scores: opt: 410%2C E(): 2.4e-18%2C (23.9%25 identity in 237 aa overlap)%3B etc. Belongs to the complex I 24 KDA subunit family. Binds a 2FE-2S cluster (potential).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoE;locus_tag=Rv3149;product=Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E);protein_id=CCP45960.1;transl_table=11
AL123456.3	EMBL	gene	3515412	3516749	.	+	.	ID=gene-Rv3150;Name=nuoF;gbkey=Gene;gene=nuoF;gene_biotype=protein_coding;locus_tag=Rv3150
AL123456.3	EMBL	CDS	3515412	3516749	.	+	0	ID=cds-CCP45961.1;Parent=gene-Rv3150;Dbxref=EnsemblGenomes-Gn:Rv3150,EnsemblGenomes-Tr:CCP45961,GOA:P9WIV7,InterPro:IPR001949,InterPro:IPR011537,InterPro:IPR011538,InterPro:IPR019554,InterPro:IPR019575,NCBI_GP:CCP45961.1;Name=CCP45961.1;Note=Rv3150%2C (MTCY03A2.08c)%2C len: 445 aa. Probable nuoF%2CNADH dehydrogenase%2C chain F%2C similar to others e.g. Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449 aa)%2CFASTA scores: opt: 2314%2C E(): 3.5e-139%2C (76.25%25 identity in 434 aa overlap)%3B NUF2_RHIME from Rhizobium meliloti (421 aa)%2C FASTA scores: opt: 1545%2C E(): 1.8e-90%2C (53.1%25 identity in 424 aa overlap)%3B Q9RU92|DR1500 from Deinococcus radiodurans (444 aa)%2C FASTA scores: opt: 1445%2C E(): 4.1e-84%2C (52.9%25 identity in 427 aa overlap)%3B etc. Contains respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2 (PS00645). Belongs to the complex I 51 KDA subunit family. Cofactor: FMN and one 4FE-4S cluster (probable).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoF;inference=protein motif:PROSITE:PS00645;locus_tag=Rv3150;product=Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F);protein_id=CCP45961.1;transl_table=11
AL123456.3	EMBL	gene	3516746	3519166	.	+	.	ID=gene-Rv3151;Name=nuoG;gbkey=Gene;gene=nuoG;gene_biotype=protein_coding;locus_tag=Rv3151
AL123456.3	EMBL	CDS	3516746	3519166	.	+	0	ID=cds-CCP45962.1;Parent=gene-Rv3151;Dbxref=EnsemblGenomes-Gn:Rv3151,EnsemblGenomes-Tr:CCP45962,GOA:P9WIV9,InterPro:IPR000283,InterPro:IPR001041,InterPro:IPR006656,InterPro:IPR006657,InterPro:IPR006963,InterPro:IPR009010,InterPro:IPR010228,InterPro:IPR012675,InterPro:IPR019574,NCBI_GP:CCP45962.1;Name=CCP45962.1;Note=Rv3151%2C (MTCY03A2.07c)%2C len: 806 aa. Probable nuoG%2CNADH dehydrogenase I%2C chain G%2C similar to others e.g. Q9XAR0|NUOG_STRCO from Streptomyces coelicolor (843 aa)%2CFASTA scores: opt: 1968 %2CE(): 5.2e-107%2C (62.45%25 identity in 818 aa overlap)%3B P56914|NUG2_RHIME from Rhizobium meliloti (853 aa)%2C FASTA scores: opt: 964%2C E(): 1.6e-48%2C (30.6%25 identity in 840 aa overlap)%3B etc. But also similarity with other proteins e.g. P77908|FDHA formate dehydrogenase%2Calpha subunit (formate dehydrogenase [NADP+]) from Moorella thermoacetica (Clostridium thermoaceticum) (893 aa)%2C FASTA scores: opt: 928%2C E(): 2e-46%2C (28.65%25 identity in 865 aa overlap)%3B and Q9UUU3|NUAM NUAM protein precursor from Yarrowia lipolytica (Candida lipolytica) (728 aa)%2C FASTA scores: opt: 894%2C E(): 1.7e-44%2C (31.95%25 identity in 676 aa overlap). Equivalent to AAK47578 from Mycobacterium tuberculosis strain CDC1551 but longer 15 aa. Contains respiratory-chain NADH dehydrogenase 75 kDa subunit signature 2 (PS00642). Belongs to the complex I 75 KDA subunit family. Cofactor: may bind two 4FE-4S cluster and one 2FE-2S cluster.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoG;inference=protein motif:PROSITE:PS00642;locus_tag=Rv3151;product=Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G);protein_id=CCP45962.1;transl_table=11
AL123456.3	EMBL	gene	3519282	3520514	.	+	.	ID=gene-Rv3152;Name=nuoH;gbkey=Gene;gene=nuoH;gene_biotype=protein_coding;locus_tag=Rv3152
AL123456.3	EMBL	CDS	3519282	3520514	.	+	0	ID=cds-CCP45963.1;Parent=gene-Rv3152;Dbxref=EnsemblGenomes-Gn:Rv3152,EnsemblGenomes-Tr:CCP45963,GOA:P9WIX1,InterPro:IPR001694,InterPro:IPR018086,NCBI_GP:CCP45963.1;Name=CCP45963.1;Note=Rv3152%2C (MTCY03A2.06c)%2C len: 410 aa. Probable nuoH%2Cintegral membrane NADH dehydrogenase I%2C chain H%2C similar to others e.g. Q9XAR1 Q9XAR1|NUOH from Streptomyces coelicolor (467 aa)%2C FASTA scores: opt: 1630%2C E(): 3.4e-90%2C (58.35%25 identity in 413 aa overlap)%3B Q9RU94|DR1498 from Deinococcus radiodurans (397 aa)%2C FASTA scores: opt: 1081%2C E(): 2e-57%2C(45.5%25 identity in 391 aa overlap)%3B Q9ZCF7|NUOH_RICPR|RP796 from Rickettsia prowazekii (339 aa)%2C FASTA scores: opt: 976%2C E(): 3.4e-51%2C (46.2%25 identity in 329 aa overlap)%3B etc. Contains respiratory-chain NADH dehydrogenase subunit 1 signature 2 (PS00668). Some similarity to MTCY251.02 (FASTA score: E(): 1.2e-07). Belongs to the complex I subunit 1 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoH;inference=protein motif:PROSITE:PS00668;locus_tag=Rv3152;product=Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H);protein_id=CCP45963.1;transl_table=11
AL123456.3	EMBL	gene	3520507	3521142	.	+	.	ID=gene-Rv3153;Name=nuoI;gbkey=Gene;gene=nuoI;gene_biotype=protein_coding;locus_tag=Rv3153
AL123456.3	EMBL	CDS	3520507	3521142	.	+	0	ID=cds-CCP45964.1;Parent=gene-Rv3153;Dbxref=EnsemblGenomes-Gn:Rv3153,EnsemblGenomes-Tr:CCP45964,GOA:P9WJG9,InterPro:IPR001450,InterPro:IPR010226,InterPro:IPR017896,InterPro:IPR017900,NCBI_GP:CCP45964.1;Name=CCP45964.1;Note=Rv3153%2C (MTCY03A2.05c)%2C len: 211 aa. Probable nuoI%2CNADH dehydrogenase I%2C chain I%2C similar to others e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211 aa)%2C FASTA scores: opt: 825%2C E(): 9.3e-44%2C (70.1%25 identity in 164 aa overlap)%3B Q56224|NQO9_THETH from Thermus aquaticus (subsp. thermophilus) (182 aa)%2C FASTA scores: opt: 543%2C E(): 1.8e-26%2C (50.9%25 identity in 163 aa overlap)%3B Q9RU95|DR1497 from Deinococcus radiodurans (178 aa)%2C FASTA scores: opt: 527%2C E(): 1.7e-25%2C (48.75%25 identity in 162 aa overlap)%3B etc. Contains two 4Fe-4S ferredoxins%2C iron-sulfur binding region signatures (PS00198). Belongs to the complex I 23 KDA subunit family. The iron-sulfur centers are similar to those of 'bacterial-type' 4FE-4S ferredoxins. Cofactor: binds two 4FE-4S clusters.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoI;inference=protein motif:PROSITE:PS00198;locus_tag=Rv3153;product=Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I);protein_id=CCP45964.1;transl_table=11
AL123456.3	EMBL	gene	3521139	3521927	.	+	.	ID=gene-Rv3154;Name=nuoJ;gbkey=Gene;gene=nuoJ;gene_biotype=protein_coding;locus_tag=Rv3154
AL123456.3	EMBL	CDS	3521139	3521927	.	+	0	ID=cds-CCP45965.1;Parent=gene-Rv3154;Dbxref=EnsemblGenomes-Gn:Rv3154,EnsemblGenomes-Tr:CCP45965,GOA:P95172,InterPro:IPR001457,UniProtKB/TrEMBL:P95172,NCBI_GP:CCP45965.1;Name=CCP45965.1;Note=Rv3154%2C (MTCY03A2.04c)%2C len: 262 aa. Probable nuoJ%2Ctransmembrane NADH dehydrogenase I%2C chain J%2C similar to others e.g. Q9XAR3|NUOJ from Streptomyces coelicolor (285 aa)%2C FASTA scores: opt: 991%2C E(): 3.2e-52%2C (63.7%25 identity in 243 aa overlap)%3B Q9JX90|NUOJ|NMA0006 from Neisseria meningitidis (serogroup A) (223 aa)%2C FASTA scores: opt: 329%2C E(): 9.6e-13%2C (34.85%25 identity in 175 aa overlap)%3B Q9K1B2|NMB0253 from Neisseria meningitidis (serogroup B) (223 aa)%2C FASTA scores: opt: 326%2C E(): 1.5e-12%2C (34.85%25 identity in 175 aa overlap)%3B etc. But also similarity with Q00243|NU6C_PLEBO|NDH6 NADH-plastoquinone oxidoreductase chain 6 homolog (catalytic activity: NADH + plastoquinone %3D NAD(+) + plastoquinol) from Plectonema boryanum (199 aa)%2CFASTA scores: opt: 287%2C E(): 2.8e-10%2C (34.35%25 identity in 195 aa overlap). Similar to polypeptide 6 of the NADH-ubiquinol oxidoreductase of chloroplasts or mitochondria.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoJ;locus_tag=Rv3154;product=Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J);protein_id=CCP45965.1;transl_table=11
AL123456.3	EMBL	gene	3521924	3522223	.	+	.	ID=gene-Rv3155;Name=nuoK;gbkey=Gene;gene=nuoK;gene_biotype=protein_coding;locus_tag=Rv3155
AL123456.3	EMBL	CDS	3521924	3522223	.	+	0	ID=cds-CCP45966.1;Parent=gene-Rv3155;Dbxref=EnsemblGenomes-Gn:Rv3155,EnsemblGenomes-Tr:CCP45966,GOA:P9WIX3,InterPro:IPR001133,NCBI_GP:CCP45966.1;Name=CCP45966.1;Note=Rv3155%2C (MTCY03A2.03c)%2C len: 99 aa. Probable nuoK%2Cintegral membrane NADH dehydrogenase I%2C chain K%2C similar to others e.g. Q9XAR4|NUOK from Streptomyces coelicolor (99 aa)%2C FASTA scores: opt: 509%2C E(): 2.7e-31%2C (78.55%25 identity in 98 aa overlap)%3B Q56226|NQOB_THETH|NQO11 from Thermus aquaticus (subsp. thermophilus) (95 aa)%2C blast scores: initn: 298%2C init1: 180%2C bits: 85.7%2C FASTA scores: opt: 313%2CE(): 9.4e-17%2C (53.7%25 identity in 95 aa overlap)%3B Q9RU97|DR1495 from Deinococcus radiodurans (103 aa)%2C FASTA scores: opt: 309%2C E(): 2e-16%2C (52.0%25 identity in 100 aa overlap)%3B etc. But also similarity with NADH-plastoquinone oxidoreductases chain 4L e.g. Q9MUL4|NULC_MESVI|NDHE from Mesostigma viride (catalytic activity: NADH + plastoquinone %3D NAD(+) + plastoquinol) (101 aa)%2C FASTA scores: opt: 280%2CE(): 2.8e-14%2C (40.6%25 identity in 101 aa overlap)%3B and P06261|NULC_TOBAC|NDHE|NDH4L from Nicotiana tabacum (Common tobacco) (101 aa)%2C FASTA scores: opt: 259%2C E(): 1e-12%2C(43.0%25 identity in 93 aa overlap). Similar to polypeptide 4L of the NADH-ubiquinol oxidoreductase of chloroplasts or mitochondria.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoK;locus_tag=Rv3155;product=Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase chain K);protein_id=CCP45966.1;transl_table=11
AL123456.3	EMBL	gene	3522234	3524135	.	+	.	ID=gene-Rv3156;Name=nuoL;gbkey=Gene;gene=nuoL;gene_biotype=protein_coding;locus_tag=Rv3156
AL123456.3	EMBL	CDS	3522234	3524135	.	+	0	ID=cds-CCP45967.1;Parent=gene-Rv3156;Dbxref=EnsemblGenomes-Gn:Rv3156,EnsemblGenomes-Tr:CCP45967,GOA:P9WIW1,InterPro:IPR001516,InterPro:IPR001750,InterPro:IPR003945,InterPro:IPR018393,NCBI_GP:CCP45967.1;Name=CCP45967.1;Note=Rv3156%2C (MTCY03A2.02c)%2C len: 633 aa. Probable nuoL%2Cintegral membrane NADH dehydrogenase I%2C chain L%2C similar to others e.g. Q9XAR5|NUOL_STRCO from Streptomyces coelicolor (654 aa)%2C FASTA scores: opt: 2074%2C E(): 1.1e-111%2C (61.1%25 identity in 648 aa overlap)%3B Q56227|NQOC_THETH|NQO12 from Thermus aquaticus (subsp. thermophilus) (606 aa)%2C FASTA scores: opt: 1420%2C E(): 3.8e-74%2C (43.35%25 identity in 630 aa overlap)%3B Q9ZJV6|NUOL|JHP1192 from Helicobacter pylori J99 (Campylobacter pylori J99) (612 aa)%2C FASTA scores: opt: 1279%2C E(): 4.7e-66%2C (41.65%25 identity in 516 aa overlap)%3B etc. Also similar to MTCY251.04 (FASTA score: E(): 1.3e-11) and MTCY03A2.01c (FASTA score: E(): 2.3e-10). Similar to polypeptide 5 of the NADH-ubiquinol oxidoreductase of chloroplasts or mitochondrial.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoL;locus_tag=Rv3156;product=Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L);protein_id=CCP45967.1;transl_table=11
AL123456.3	EMBL	gene	3524132	3525793	.	+	.	ID=gene-Rv3157;Name=nuoM;gbkey=Gene;gene=nuoM;gene_biotype=protein_coding;locus_tag=Rv3157
AL123456.3	EMBL	CDS	3524132	3525793	.	+	0	ID=cds-CCP45968.1;Parent=gene-Rv3157;Dbxref=EnsemblGenomes-Gn:Rv3157,EnsemblGenomes-Tr:CCP45968,GOA:P9WIW5,InterPro:IPR001750,InterPro:IPR003918,InterPro:IPR010227,NCBI_GP:CCP45968.1;Name=CCP45968.1;Note=Rv3157%2C (MTCY03A2.01c-MTV014.01c)%2C len: 553 aa. Probable nuoM%2C integral membrane NADH dehydrogenase I%2Cchain M%2C similar to others e.g. Q9XAR6|NUOM from Streptomyces coelicolor (523 aa)%2C FASTA scores: opt: 1621%2CE(): 4.2e-89%2C (56.55%25 identity in 541 aa overlap)%3B P50974|NUOM_RHOCA|NUOM from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (512 aa)%2C FASTA scores: opt: 996%2C E(): 6.5e-52%2C (38.2%25 identity in 521 aa overlap)%3B P29925|NQOD_PARDE|NQO13 from Paracoccus denitrificans (513 aa)%2C FASTA scores: opt: 987%2C E(): 2.2e-51%2C (37.05%25 identity in 540 aa overlap)%3B etc. Also similar to MTCY251.04 (FASTA score: E(): 3.3e-16) and MTCY03A2.02c (FASTA score: E(): 9.6e-13). Similar to polypeptide 4 of the NADH-ubiquinol oxidoreductase of chloroplasts or mitochondrial.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoM;locus_tag=Rv3157;product=Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M);protein_id=CCP45968.1;transl_table=11
AL123456.3	EMBL	gene	3525790	3527385	.	+	.	ID=gene-Rv3158;Name=nuoN;gbkey=Gene;gene=nuoN;gene_biotype=protein_coding;locus_tag=Rv3158
AL123456.3	EMBL	CDS	3525790	3527385	.	+	0	ID=cds-CCP45969.1;Parent=gene-Rv3158;Dbxref=EnsemblGenomes-Gn:Rv3158,EnsemblGenomes-Tr:CCP45969,GOA:P9WIW9,InterPro:IPR001750,InterPro:IPR010096,NCBI_GP:CCP45969.1;Name=CCP45969.1;Note=Rv3158%2C (MTV014.02c)%2C len: 531 aa. Probable nuoN%2Cintegral membrane NADH dehydrogenase I%2C chain N%2C similar to others e.g. Q9XAR7|SC10A7.08c from Streptomyces coelicolor (552 aa)%2C FASTA scores: opt: 1493%2C E(): 1.1e-81%2C (56.7%25 identity in 543 aa overlap)%3B Q9PGI2|XF0318 from Xylella fastidiosa (485 aa)%2C FASTA scores: opt: 942%2C E(): 7.4e-49%2C(39.6%25 identity in 379 aa overlap)%3B CAB51628|NUON2 from Rhizobium meliloti (Sinorhizobium meliloti) (479 aa)%2C FASTA scores: opt: 934%2C E(): 2.2e-48%2C (35.5%25 identity in 479 aa overlap)%3B etc. But also similarity with NADH-plastoquinone oxidoreductases chain 4L (catalytic activity: NADH + plastoquinone %3D NAD(+) + plastoquinol) e.g. P29801|NU2C_SYNP7|NDHB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (521 aa)%2C FASTA scores: opt: 921%2C E(): 1.4e-47%2C (40.25%25 identity in 395 aa overlap). Belongs to the complex I subunit 2 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nuoN;locus_tag=Rv3158;product=Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N);protein_id=CCP45969.1;transl_table=11
AL123456.3	EMBL	gene	3527391	3529163	.	-	.	ID=gene-Rv3159c;Name=PPE53;gbkey=Gene;gene=PPE53;gene_biotype=protein_coding;locus_tag=Rv3159c
AL123456.3	EMBL	CDS	3527391	3529163	.	-	0	ID=cds-CCP45970.1;Parent=gene-Rv3159c;Dbxref=EnsemblGenomes-Gn:Rv3159c,EnsemblGenomes-Tr:CCP45970,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:Q6MX04,NCBI_GP:CCP45970.1;Name=CCP45970.1;Note=Rv3159c%2C (MTV014.03c)%2C len: 590 aa. PPE53%2C Member of the Mycobacterium tuberculosis PPE_family of Gly-%2C Asn-rich proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582 aa)%2C FASTA scores: opt: 2289%2C E(): 3.2e-98%2C (63.5%25 identity in 600 aa overlap)%3B and also similar to MTCY48_17%2CMTV041_29%2C MTCY6G11_5%2C MTCY98_24%2C etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE53;locus_tag=Rv3159c;product=PPE family protein PPE53;protein_id=CCP45970.1;transl_table=11
AL123456.3	EMBL	gene	3529338	3529979	.	-	.	ID=gene-Rv3160c;Name=Rv3160c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3160c
AL123456.3	EMBL	CDS	3529338	3529979	.	-	0	ID=cds-CCP45971.1;Parent=gene-Rv3160c;Dbxref=EnsemblGenomes-Gn:Rv3160c,EnsemblGenomes-Tr:CCP45971,GOA:O53310,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,InterPro:IPR023772,UniProtKB/TrEMBL:O53310,NCBI_GP:CCP45971.1;Name=CCP45971.1;Note=Rv3160c%2C (MTV014.04c)%2C len: 213 aa. Possible transcriptional regulator%2C with some similarity to others e.g. Q9S3L4|AMTR AMTR protein (global repressor in the nitrogen regulation system%3B see Jakoby et al.%2C 2000) (222 aa)%2C FASTA scores: opt: 182%2C E(): 7.3e-05%2C (27.9%25 identity in 208 aa overlap)%3B Q9X7X9|SC6A5.33c putative regulatory protein from Streptomyces coelicolor (223 aa)%2C FASTA scores: opt: 176%2C E(): 0.00018%2C (26.5%25 identity in 185 aa overlap)%3B Q9XA31|SCH69.03c putative transcriptional regulator from Streptomyces coelicolor (209 aa)%2C FASTA scores: opt: 173%2C E(): 0.00027%2C (27.25%25 identity in 176 aa overlap)%3B BAB54133|MLL7734 transcriptional regulator from Rhizobium loti (Mesorhizobium loti) (213 aa)%2C FASTA scores: opt: 172%2C E(): 0.00031%2C (23.55%25 identity in 204 aa overlap)%3B etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis strain H37Rv e.g. P96839|Rv3557v|MTCY06G11.04c (200 aa)%2C FASTA scores: opt: 169%2C E(): 0.00046%2C (26.75%25 identity in 157 aa overlap). Contains probable helix-turn-helix motif from aa 31 to 52 (Score 1857%2C +5.51 SD). Similar to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3160c;product=Possible transcriptional regulatory protein (probably TetR-family);protein_id=CCP45971.1;transl_table=11
AL123456.3	EMBL	gene	3529990	3531138	.	-	.	ID=gene-Rv3161c;Name=Rv3161c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3161c
AL123456.3	EMBL	CDS	3529990	3531138	.	-	0	ID=cds-CCP45972.1;Parent=gene-Rv3161c;Dbxref=EnsemblGenomes-Gn:Rv3161c,EnsemblGenomes-Tr:CCP45972,GOA:O53311,InterPro:IPR001663,InterPro:IPR015879,InterPro:IPR017941,UniProtKB/TrEMBL:O53311,NCBI_GP:CCP45972.1;Name=CCP45972.1;Note=Rv3161c%2C (MTV014.05c)%2C len: 382 aa. Possible dioxygenase%2C similar to subunit of several dioxygenases and related proteins e.g. BAB50510|MLR3662 dioxygenase%2C alpha subunit from Rhizobium loti (Mesorhizobium loti) (400 aa)%2CFASTA scores: opt: 413%2C E(): 6.2e-20%2C (28.4%25 identity in 331 aa overlap)%3B Q9A3T0|CC3122 rieske 2FE-2S family protein from Caulobacter crescentus (404 aa)%2C FASTA scores: opt: 405%2C E(): 2.1e-19%2C (27.95%25 identity in 372 aa overlap)%3B Q9HTF4|PA5410 probable ring hydroxylating dioxygenase%2Calpha-subunit from Pseudomonas aeruginosa (429 aa)%2C FASTA scores: opt: 392%2C E(): 1.6e-18%2C (25.8%25 identity in 399 aa overlap)%3B Q9AGK6|PHTAA phthalate dioxygenase large subunit from Arthrobacter keyseri (473 aa)%2C FASTA scores: opt: 385%2CE(): 5.2e-18%2C (34.0%25 identity in 206 aa overlap)%3B P76253|YEAW_ECOLI putative dioxygenase%2C alpha subunit from Escherichia coli (374 aa)%2C FASTA scores: opt: 376%2C E(): 1.7e-17%2C (27.05%25 identity in 344 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3161c;product=Possible dioxygenase;protein_id=CCP45972.1;transl_table=11
AL123456.3	EMBL	gene	3531208	3531645	.	-	.	ID=gene-Rv3162c;Name=Rv3162c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3162c
AL123456.3	EMBL	CDS	3531208	3531645	.	-	0	ID=cds-CCP45973.1;Parent=gene-Rv3162c;Dbxref=EnsemblGenomes-Gn:Rv3162c,EnsemblGenomes-Tr:CCP45973,UniProtKB/TrEMBL:O53312,NCBI_GP:CCP45973.1;Name=CCP45973.1;Note=Rv3162c%2C (MTV014.06c)%2C len: 145 aa. Possible integral membrane protein%2C with some similarity to C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical protein from Mycobacterium tuberculosis (287 aa)%2C FASTA scores: opt: 112%2C E(): 6.9%2C (29.65%25 identity in 135 aa overlap)%3B and other hypothetical proteins from other organisms.;gbkey=CDS;locus_tag=Rv3162c;product=Possible integral membrane protein;protein_id=CCP45973.1;transl_table=11
AL123456.3	EMBL	gene	3531642	3532913	.	-	.	ID=gene-Rv3163c;Name=Rv3163c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3163c
AL123456.3	EMBL	CDS	3531642	3532913	.	-	0	ID=cds-CCP45974.1;Parent=gene-Rv3163c;Dbxref=EnsemblGenomes-Gn:Rv3163c,EnsemblGenomes-Tr:CCP45974,InterPro:IPR002881,UniProtKB/TrEMBL:O53313,NCBI_GP:CCP45974.1;Name=CCP45974.1;Note=Rv3163c%2C (MTV014.07c)%2C len: 423 aa. Possible conserved secreted protein%2C with some similarity to other hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from Streptomyces coelicolor (460 aa)%2C FASTA scores: opt: 666%2CE(): 1.5e-33%2C (33.55%25 identity in 417 aa overlap)%3B O58486|PH0774 from Pyrococcus horikoshii (410 aa)%2C FASTA scores: opt: 329%2C E(): 6.9e-13%2C (23.8%25 identity in 424 aa overlap)%3B Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa)%2CFASTA scores: opt: 322%2C E(): 1.9e-12%2C (24.15%25 identity in 389 aa overlap)%3B etc. Also some similarity with P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium tuberculosis (317 aa)%2C FASTA scores: opt: 198%2C E(): 6.3e-05%2C (26.75%25 identity in 269 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.;gbkey=CDS;inference=protein motif:PROSITE:PS00402;locus_tag=Rv3163c;product=Possible conserved secreted protein;protein_id=CCP45974.1;transl_table=11
AL123456.3	EMBL	gene	3532943	3533905	.	-	.	ID=gene-Rv3164c;Name=moxR3;gbkey=Gene;gene=moxR3;gene_biotype=protein_coding;locus_tag=Rv3164c
AL123456.3	EMBL	CDS	3532943	3533905	.	-	0	ID=cds-CCP45975.1;Parent=gene-Rv3164c;Dbxref=EnsemblGenomes-Gn:Rv3164c,EnsemblGenomes-Tr:CCP45975,GOA:O53314,InterPro:IPR011703,InterPro:IPR016366,InterPro:IPR027417,UniProtKB/TrEMBL:O53314,NCBI_GP:CCP45975.1;Name=CCP45975.1;Note=Rv3164c%2C (MTV014.08c)%2C len: 320 aa. Probable moxR3%2Cmethanol dehydrogenase regulatory protein%2C highly similar to Q9Z538|SC9B2.21c putative regulatory protein from Streptomyces coelicolor (332 aa)%2C FASTA scores: opt: 1227%2CE(): 1.7e-67%2C (60.25%25 identity in 302 aa overlap)%3B Q9UZ67|MOXR-3|PAB0848 methanol dehydrogenase regulatory protein from Pyrococcus abyssi (314 aa)%2C FASTA scores: opt: 1126%2C E(): 2.3e-61%2C (54.1%25 identity in 305 aa overlap)%3B Q9HSH7|MOXR|VNG0223G methanol dehydrogenase regulatory protein from Halobacterium sp. strain NRC-1 (318 aa)%2C FASTA scores: opt: 1072%2C E(): 4.5e-58%2C (51.45%25 identity in 315 aa overlap)%3B Q9RVV4|DR0918 MOXR-related protein from Deinococcus radiodurans (354 aa)%2C FASTA scores: opt: 1000%2CE(): 1.2e-53%2C (50.95%25 identity in 318 aa overlap)%3B etc. Also high similarity with several hypothetical bacterial proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moxR3;locus_tag=Rv3164c;product=Probable methanol dehydrogenase transcriptional regulatory protein MoxR3;protein_id=CCP45975.1;transl_table=11
AL123456.3	EMBL	gene	3533913	3534395	.	-	.	ID=gene-Rv3165c;Name=Rv3165c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3165c
AL123456.3	EMBL	CDS	3533913	3534395	.	-	0	ID=cds-CCP45976.1;Parent=gene-Rv3165c;Dbxref=EnsemblGenomes-Gn:Rv3165c,EnsemblGenomes-Tr:CCP45976,GOA:O53315,UniProtKB/TrEMBL:O53315,NCBI_GP:CCP45976.1;Name=CCP45976.1;Note=Rv3165c%2C (MTV014.09)c%2C len: 160 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3165c;product=Unknown protein;protein_id=CCP45976.1;transl_table=11
AL123456.3	EMBL	gene	3534392	3535351	.	-	.	ID=gene-Rv3166c;Name=Rv3166c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3166c
AL123456.3	EMBL	CDS	3534392	3535351	.	-	0	ID=cds-CCP45977.1;Parent=gene-Rv3166c;Dbxref=EnsemblGenomes-Gn:Rv3166c,EnsemblGenomes-Tr:CCP45977,InterPro:IPR025403,UniProtKB/TrEMBL:O53316,NCBI_GP:CCP45977.1;Name=CCP45977.1;Note=Rv3166c%2C (MTV014.10c)%2C len: 319 aa. Probable transmembrane protein%2C similar but longer (52 aa) to O32895|MLCB1779.35c hypothetical protein from Mycobacterium leprae (119 aa)%2C FASTA scores: opt: 289%2C E(): 3.7e-10%2C(44.25%25 identity in 122 aa overlap). Also some similarity to Q9Z536|SC9B2.23c putative transmembrane protein from Streptomyces coelicolor (339 aa)%2C FASTA scores: opt: 247%2CE(): 2.5e-07%2C (28.2%25 identity in 326 aa overlap)%3B and in N-terminus to Q9RS20|DR2307 putative multidrug-efflux transporter from Deinococcus radiodurans (410 aa)%2C FASTA scores: opt: 135%2CE(): 1%2C (32.35%25 identity in 136 aa overlap).;gbkey=CDS;locus_tag=Rv3166c;product=Conserved hypothetical protein;protein_id=CCP45977.1;transl_table=11
AL123456.3	EMBL	gene	3535431	3536057	.	-	.	ID=gene-Rv3167c;Name=Rv3167c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3167c
AL123456.3	EMBL	CDS	3535431	3536057	.	-	0	ID=cds-CCP45978.1;Parent=gene-Rv3167c;Dbxref=EnsemblGenomes-Gn:Rv3167c,EnsemblGenomes-Tr:CCP45978,GOA:O53317,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O53317,NCBI_GP:CCP45978.1;Name=CCP45978.1;Note=Rv3167c%2C (MTV014.11c)%2C len: 208 aa. Probable transcriptional regulator%2C TetR family%2C similar to several transcriptional regulators e.g. Q9L2A4|SC8F4.22c (TetR/AcrR family) from Streptomyces coelicolor (234 aa)%2C FASTA scores: opt: 317%2C E(): 7.5e-13%2C (33.35%25 identity in 210 aa overlap)%3B Q9RK47|SCF12.11 (TetR/AcrR family) from Streptomyces coelicolor (206 aa)%2C FASTA scores: opt: 293%2CE(): 2.1e-11%2C (32.65%25 identity in 199 aa overlap)%3B Q54288 regulator of antibiotic transport complexes (TetR/AcrR family) (204 aa)%2C FASTA scores: opt: 260%2C E(): 2.4e-09%2C(30.75%25 identity in 205 aa overlap)%3B etc. Equivalent to AAK47595 from Mycobacterium tuberculosis strain CDC1551 but shorter 21 aa. Contains probable helix-turn-helix motif from aa 42 to 63 (Score 1727%2C +5.07 SD). May belong to the TetR/AcrR family of transcriptional regulators.;gbkey=CDS;locus_tag=Rv3167c;product=Probable transcriptional regulatory protein (probably TetR-family);protein_id=CCP45978.1;transl_table=11
AL123456.3	EMBL	gene	3536102	3537238	.	+	.	ID=gene-Rv3168;Name=Rv3168;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3168
AL123456.3	EMBL	CDS	3536102	3537238	.	+	0	ID=cds-CCP45979.1;Parent=gene-Rv3168;Dbxref=EnsemblGenomes-Gn:Rv3168,EnsemblGenomes-Tr:CCP45979,GOA:P9WI99,InterPro:IPR002575,InterPro:IPR011009,PDB:3ATS,PDB:3ATT,NCBI_GP:CCP45979.1;Name=CCP45979.1;Note=Rv3168%2C (MTV014.12)%2C len: 378 aa. Putative aminoglycoside phosphotransferase%2C similar to hypothetical proteins e.g. Q9M7Y6|F3E22.6 from Arabidopsis thaliana (Mouse-ear cress) (314 aa)%2C FASTA scores: opt: 236%2C E(): 1.1e-07%2C (27.35%25 identity in 234 aa overlap)%3B Q9RYW2|DRA0194 from Deinococcus radiodurans (386 aa)%2C FASTA scores: opt: 207%2C E(): 9.1e-06%2C (23.45%25 identity in 320 aa overlap)%3B etc. Also some similarity with O69727|Rc3761c|MTV025.109c hypothetical protein from Mycobacterium tuberculosis (351 aa)%2C FASTA scores: opt: 193%2C E(): 6.4e-05%2C (29.4%25 identity in 242 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3168;product=Putative aminoglycoside phosphotransferase;protein_id=CCP45979.1;transl_table=11
AL123456.3	EMBL	gene	3537238	3538362	.	+	.	ID=gene-Rv3169;Name=Rv3169;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3169
AL123456.3	EMBL	CDS	3537238	3538362	.	+	0	ID=cds-CCP45980.1;Parent=gene-Rv3169;Dbxref=EnsemblGenomes-Gn:Rv3169,EnsemblGenomes-Tr:CCP45980,GOA:O53319,UniProtKB/TrEMBL:O53319,NCBI_GP:CCP45980.1;Name=CCP45980.1;Note=Rv3169%2C (MTV014.13)%2C len: 374 aa. Conserved protein%2Cwith similarity to other hypothetical proteins: Q9A8W6|CC1232 from Caulobacter crescentus (368 aa)%2C FASTA scores: opt: 669%2C E(): 3.3e-34%2C (34.05%25 identity in 376 aa overlap)%3B and O32901|MLCB1779.41 from Mycobacterium leprae (127 aa)%2C FASTA scores: opt: 179%2C E(): 0.00034%2C (29.0%25 identity in 131 aa overlap). Also weak similarity with P95149|Rv1866|MTCY359.07c (804 aa)%2C FASTA scores: opt: 121%2CE(): 6.4%2C (37.0%25 identity in 119 aa overlap). Equivalent to AAK47597 from Mycobacterium tuberculosis strain CDC1551 but shorter 43 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00092;locus_tag=Rv3169;product=Conserved protein;protein_id=CCP45980.1;transl_table=11
AL123456.3	EMBL	gene	3538505	3539851	.	+	.	ID=gene-Rv3170;Name=aofH;gbkey=Gene;gene=aofH;gene_biotype=protein_coding;locus_tag=Rv3170
AL123456.3	EMBL	CDS	3538505	3539851	.	+	0	ID=cds-CCP45981.1;Parent=gene-Rv3170;Dbxref=EnsemblGenomes-Gn:Rv3170,EnsemblGenomes-Tr:CCP45981,GOA:P9WQ15,InterPro:IPR001613,InterPro:IPR002937,InterPro:IPR016040,NCBI_GP:CCP45981.1;Name=CCP45981.1;Note=Rv3170%2C (MT3259%2C MTV014.14)%2C len: 448 aa. Probable aofH%2C flavin-containing (mono)amine oxidase%2C equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below)%2C and similar to many eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) (522 aa)%2C FASTA scores: opt: 869%2C E(): 5.3e-44%2C (37.7%25 identity in 448 aa overlap)%3B P21396|AOFA_RAT|MAOA from Rattus norvegicus (Rat) (526 aa)%2C FASTA scores: opt: 839%2C E(): 3.2e-42%2C (37.45%25 identity in 446 aa overlap)%3B Q99NA8|MAO-a from Cavia porcellus (Guinea pig) (506 aa)%2C FASTA scores: opt: 836%2CE(): 4.6e-42%2C (37.0%25 identity in 446 aa overlap)%3B P21398|AOFA_BOVIN from Bos taurus (Bovine) (527 aa)%2C FASTA scores: opt: 806%2C E(): 2.8e-40%2C (37.0%25 identity in 446 aa overlap)%3B P21397|AOFA_HUMAN (527 aa)%2C FASTA scores: opt: 801%2C E(): 5.6e-40%2C (37.2%25 identity in 446 aa overlap)%3B etc. Alternative start possible at position 3538487. Belongs to the flavin monoamine oxidase family. Cofactor: FAD (potential).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aofH;locus_tag=Rv3170;product=Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO);protein_id=CCP45981.1;transl_table=11
AL123456.3	EMBL	gene	3539846	3540745	.	-	.	ID=gene-Rv3171c;Name=hpx;gbkey=Gene;gene=hpx;gene_biotype=protein_coding;locus_tag=Rv3171c
AL123456.3	EMBL	CDS	3539846	3540745	.	-	0	ID=cds-CCP45982.1;Parent=gene-Rv3171c;Dbxref=EnsemblGenomes-Gn:Rv3171c,EnsemblGenomes-Tr:CCP45982,GOA:O53321,InterPro:IPR029058,UniProtKB/TrEMBL:O53321,NCBI_GP:CCP45982.1;Name=CCP45982.1;Note=Rv3171c%2C (MTV014.15c)%2C len: 299 aa. Possible hpx%2Cnon-heme haloperoxidase%2C similar to other hydrolases (principaly epoxide hydrolases) and non-heme chloroperoxidases e.g. Q9RKB6|SCE87.22c putative hydrolase from Streptomyces coelicolor (314 aa)%2C FASTA scores: opt: 431%2C E(): 6e-20%2C (38.05%25 identity in 297 aa overlap)%3B Q9HZ14|PA3226 probable hydrolase (similar to alpha/beta hydrolase fold) from Pseudomonas aeruginosa (275 aa)%2C FASTA scores: opt: 236%2C E(): 1e-07%2C (29.6%25 identity in 277 aa overlap)%3B Q9DBL9|1300003 D03RIK protein similar to alpha/beta hydrolase fold from Mus musculus (Mouse) (351 aa)%2C FASTA scores: opt: 223%2C E(): 8.3e-07%2C (24.35%25 identity in 304 aa overlap)%3B AAK46260|MT1988 epoxide hydrolase from Mycobacterium tuberculosis strain CDC1551 (356 aa)%2C FASTA scores: opt: 223%2C E(): 8.4e-07%2C (40.7%25 identity in 113 aa overlap)%3B P49323|PRXC_STRLI|CPO|CPOL non-heme chloroperoxidase (chloride peroxidase) from Streptomyces lividans (275 aa)%2C FASTA scores: opt: 220%2C E(): 1e-06%2C(29.5%25 identity in 305 aa overlap)%3B etc. Equivalent to AAK47599 Hydrolase%2C alpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 but shorter 24 aa. Start chosen by similarity%2C alternative with good RBS possible.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hpx;locus_tag=Rv3171c;product=Possible non-heme haloperoxidase Hpx;protein_id=CCP45982.1;transl_table=11
AL123456.3	EMBL	gene	3540882	3541364	.	-	.	ID=gene-Rv3172c;Name=Rv3172c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3172c
AL123456.3	EMBL	CDS	3540882	3541364	.	-	0	ID=cds-CCP45983.1;Parent=gene-Rv3172c;Dbxref=EnsemblGenomes-Gn:Rv3172c,EnsemblGenomes-Tr:CCP45983,UniProtKB/TrEMBL:O53322,NCBI_GP:CCP45983.1;Name=CCP45983.1;Note=Rv3172c%2C (MTV014.16c)%2C len: 160 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3172c;product=Hypothetical protein;protein_id=CCP45983.1;transl_table=11
AL123456.3	EMBL	gene	3541443	3542045	.	-	.	ID=gene-Rv3173c;Name=Rv3173c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3173c
AL123456.3	EMBL	CDS	3541443	3542045	.	-	0	ID=cds-CCP45984.1;Parent=gene-Rv3173c;Dbxref=EnsemblGenomes-Gn:Rv3173c,EnsemblGenomes-Tr:CCP45984,GOA:O53323,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O53323,NCBI_GP:CCP45984.1;Name=CCP45984.1;Note=Rv3173c%2C (MTV014.17c)%2C len: 200 aa. Probable transcriptional regulatory protein TetR family%2C similar to several bacterial putative regulatory proteins e.g. Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa)%2CFASTA scores: opt: 319%2C E(): 1.7e-13%2C (34.55%25 identity in 195 aa overlap)%3B O85695|3SCF60.04 from Streptomyces lividans and Streptomyces coelicolor (192 aa)%2C FASTA scores: opt: 297%2C E(): 4.3e-12%2C (37.45%25 identity in 187 aa overlap)%3B BAB50853|MLR4117 from Rhizobium loti (Mesorhizobium loti) (205 aa)%2C FASTA scores: opt: 280%2C E(): 5.5e-11%2C (31.45%25 identity in 194 aa overlap)%3B BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti) (194 aa)%2C FASTA scores: opt: 270%2C E(): 2.3e-10%2C (34.05%25 identity in 185 aa overlap)%3B etc. Also similar to other regulators from Mycobacterium tuberculosis e.g. P96839|Rv3557c|MTCY06G11.04c (200 aa)%2C FASTA scores: opt: 154%2C E(): 0.0013%2C (38.8%25 identity in 80 aa overlap). Contains probable helix-turn-helix motif from aa 39 to 60 (Score 1251%2C +3.45 SD). Similar to the TetR/AcrR family of transcriptional regulators. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3173c;product=Probable transcriptional regulatory protein (probably TetR/AcrR-family);protein_id=CCP45984.1;transl_table=11
AL123456.3	EMBL	gene	3542138	3542845	.	+	.	ID=gene-Rv3174;Name=Rv3174;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3174
AL123456.3	EMBL	CDS	3542138	3542845	.	+	0	ID=cds-CCP45985.1;Parent=gene-Rv3174;Dbxref=EnsemblGenomes-Gn:Rv3174,EnsemblGenomes-Tr:CCP45985,GOA:O53324,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O53324,NCBI_GP:CCP45985.1;Name=CCP45985.1;Note=Rv3174%2C (MTV014.18)%2C len: 235 aa. Probable oxidoreductase short-chain dehyrogenase/reductase%2C similar to others e.g. Q9RPT7|sits from Streptomyces albus (223 aa)%2C FASTA scores: opt: 654%2C E(): 6.1e-32%2C (49.3%25 identity in 215 aa overlap)%3B Q9RI61|SCJ11.46 from Streptomyces coelicolor (230 aa)%2C FASTA scores: opt: 626%2C E(): 2.9e-30%2C(50.9%25 identity in 224 aa overlap)%3B Q9A5Z1|CC2306 from Caulobacter crescentus (252 aa)%2C FASTA scores: opt: 430%2CE(): 1.3e-18%2C (39.45%25 identity in 228 aa overlap)%3B Q51641 insect-type dehydrogenase (249 aa)%2C FASTA scores: opt: 301%2CE(): 5.7e-11%2C (38.3%25 identity in 188 aa overlap)%3B Q9HXC9|PA3883 from Pseudomonas aeruginosa (276 aa)%2C FASTA scores: opt: 296%2C E(): 1.2e-10%2C (29.55%25 identity in 247 aa overlap)%3B etc. May belong to the short-chain dehydrogenases/reductases (SDR) family. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3174;product=Probable short-chain dehydrogenase/reductase;protein_id=CCP45985.1;transl_table=11
AL123456.3	EMBL	gene	3542860	3544347	.	+	.	ID=gene-Rv3175;Name=Rv3175;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3175
AL123456.3	EMBL	CDS	3542860	3544347	.	+	0	ID=cds-CCP45986.1;Parent=gene-Rv3175;Dbxref=EnsemblGenomes-Gn:Rv3175,EnsemblGenomes-Tr:CCP45986,GOA:O53325,InterPro:IPR000120,InterPro:IPR023631,UniProtKB/TrEMBL:O53325,NCBI_GP:CCP45986.1;Name=CCP45986.1;Note=Rv3175%2C (MTV014.19)%2C len: 495 aa. Possible amidase %2Csimilar to others e.g. Q9F6D0|ZHUL enantiomer selective amidase from Streptomyces sp. R1128 (507 aa)%2C FASTA scores: opt: 1328 %2CE(): 7.5e-69%2C (44.5%25 identity in 492 aa overlap)%3B BAB51815|MLR5350 probable amidase from Rhizobium loti (Mesorhizobium loti) (457 aa)%2C FASTA scores: opt: 7487%2C E(): 1.3e-35%2C (35.9%25 identity in 482 aa overlap)%3B O28325|YJ54_ARCFU|AF1954 putative amidase from Archaeoglobus fulgidus (453 aa)%2C FASTA scores: opt: 532%2CE(): 3.2e-23%2C (32.05%25 identity in 471 aa overlap)%3B etc. But also similar to glutamyl-tRNA amidotransferases who belong to amidase family e.g. Q9RTA9|DR1856 glutamyl-tRNA(GLN) amidotransferase%2C subunit A from Deinococcus radiodurans (482 aa)%2C FASTA scores: opt: 560%2C E(): 8.2e-25%2C (30.6%25 identity in 513 aa overlap)%3B Q9LCX3|GATA GLU/asp-tRNA amidotransferase subunit A from Thermus aquaticus (subsp. thermophilus) (471 aa)%2C FASTA scores: opt: 558%2C E(): 1.1e-24%2C (30.85%25 identity in 486 aa overlap)%3B Q49091|GATA_MORCA glutamyl-tRNA(GLN) amidotransferase subunit A from Moraxella catarrhalis (492 aa)%2C FASTA scores: opt: 526%2C E(): 7.5e-23%2C (30.45%25 identity in 473 aa overlap)%3B etc. Seems to belong to the amidase family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3175;product=Possible amidase (aminohydrolase);protein_id=CCP45986.1;transl_table=11
AL123456.3	EMBL	gene	3544344	3545300	.	-	.	ID=gene-Rv3176c;Name=mesT;gbkey=Gene;gene=mesT;gene_biotype=protein_coding;gene_synonym=lipS;locus_tag=Rv3176c
AL123456.3	EMBL	CDS	3544344	3545300	.	-	0	ID=cds-CCP45987.1;Parent=gene-Rv3176c;Dbxref=EnsemblGenomes-Gn:Rv3176c,EnsemblGenomes-Tr:CCP45987,GOA:Q6MX03,InterPro:IPR029058,UniProtKB/TrEMBL:Q6MX03,NCBI_GP:CCP45987.1;Name=CCP45987.1;Note=Rv3176c%2C (MTV014.20c)%2C len: 318 aa. Probable mesT%2Cepoxide hydrolase%2C similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST protein (mesoderm specific transcript (mouse) homolog) (similar to alpha/beta hydrolase fold) from Homo sapiens (Human) (335 aa)%2C FASTA scores: opt: 348%2C E(): 6e-15%2C (32.15%25 identity in 280 aa overlap)%3B AAH06639|Q07646 MEST protein from Mus musculus (Mouse) (335 aa)%2C FASTA scores: opt: 342%2C E(): 1.4e-14%2C(31.45%25 identity in 280 aa overlap)%3B Q9I8E7|MEST epoxide hydrolase from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa)%2C FASTA scores: opt: 322%2C E(): 2.7e-13%2C (29.55%25 identity in 301 aa overlap)%3B Q9PUC9|PEG1|MEST epoxide hydrolase from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa)%2C FASTA scores: opt: 322%2CE(): 2.8e-13%2C (32.35%25 identity in 207 aa overlap)%3B Q9HYH6|PA3429 probable epoxide hydrolase from Pseudomonas aeruginosa (298 aa)%2C FASTA scores: opt: 258%2C E(): 3e-09%2C(29.85%25 identity in 288 aa overlap)%3B O31243|ECHA epoxide hydrolase from Agrobacterium radiobacter (294 aa)%2C FASTA scores: opt: 202%2C E(): 1.1e-05%2C (27.0%25 identity in 278 aa overlap)%3B etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c hypothetical 31.7 KDA protein from Mycobacterium tuberculosis (288 aa)%2C FASTA scores: opt: 294%2C E(): 1.5e-11%2C (29.95%25 identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. Similar to alpha/beta hydrolase fold. May belong to peptidase family S33. Note that previously known as lipS. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mesT;locus_tag=Rv3176c;product=Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase);protein_id=CCP45987.1;transl_table=11
AL123456.3	EMBL	gene	3545447	3546307	.	+	.	ID=gene-Rv3177;Name=Rv3177;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3177
AL123456.3	EMBL	CDS	3545447	3546307	.	+	0	ID=cds-CCP45988.1;Parent=gene-Rv3177;Dbxref=EnsemblGenomes-Gn:Rv3177,EnsemblGenomes-Tr:CCP45988,GOA:O53327,InterPro:IPR000073,InterPro:IPR029058,UniProtKB/TrEMBL:O53327,NCBI_GP:CCP45988.1;Name=CCP45988.1;Note=Rv3177%2C (MTV014.21)%2C len: 286 aa. Possible peroxidase (non-haem peroxidase)%2C highly similar to Q9KJF9|W78 cultivar specificity protein (similar to alpha/beta hydrolase fold) W78 from Rhizobium leguminosarum (287 aa)%2C FASTA scores: opt: 1059%2C E(): 2.3e-59%2C (61.4%25 identity in 272 aa overlap)%3B BAB48728|MLL1328 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (286 aa)%2CFASTA scores: opt: 746%2C E(): 1.1e-39%2C (43.25%25 identity in 282 aa overlap). Similar to nonheme chloroperoxidases and related esterases e.g. O73957|SAL lipolytic enzyme from Sulfolobus acidocaldarius (314 aa)%2C FASTA scores: opt: 408%2CE(): 1.9e-18%2C (32.4%25 identity in 287 aa overlap)%3B Q9AJM9|BIOH protein involved in biotin synthesis from Kurthia sp. 538-KA26 (267 aa)%2C FASTA scores: opt: 324 %2CE(): 3.2e-13%2C (30.0%25 identity in 250 aa overlap)%3B Q9CBB1|ML2269 putative hydrolase (similar to alpha/beta hydrolase fold) from Mycobacterium leprae (265 aa)%3B O05691|THCF_RHOER non-heme haloperoxidase from Rhodococcus erythropolis (similar to other bacterial non-heme BROMO- and chloro-peroxidases) (274 aa)%2C FASTA scores: opt: 279%2C E(): 2.2e-10%2C (29.0%25 identity in 276 aa overlap)%3B Q53540|est esterase (similar to alpha/beta hydrolase fold) from Pseudomonas putida (276 aa)%2C FASTA scores: opt: 271%2C E(): 7.1e-10%2C (29.65%25 identity in 280 aa overlap)%3B etc. Also similar to O06420|BPOC|Rv0554|MTCY25D10.33 hypothetical 28.3 KDA protein (similar to alpha/beta hydrolase fold) from M. tuberculosis (262 aa)%2C FASTA scores: opt: 280 %2CE(): 1.8e-10%2C (28.0%25 identity in 257 aa overlap). Equivalent to AAK47605 from Mycobacterium tuberculosis strain CDC1551 (300 aa) but shorter 14 aa. Similar to alpha/beta hydrolase fold. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3177;product=Possible peroxidase (non-haem peroxidase);protein_id=CCP45988.1;transl_table=11
AL123456.3	EMBL	gene	3546438	3546797	.	+	.	ID=gene-Rv3178;Name=Rv3178;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3178
AL123456.3	EMBL	CDS	3546438	3546797	.	+	0	ID=cds-CCP45989.1;Parent=gene-Rv3178;Dbxref=EnsemblGenomes-Gn:Rv3178,EnsemblGenomes-Tr:CCP45989,GOA:O53328,InterPro:IPR004378,NCBI_GP:CCP45989.1;Name=CCP45989.1;Note=Rv3178%2C (MTV014.22)%2C len: 119 aa. Hypothetical protein%2C with some similarity to other hypothetical bacterial proteins (principally mycobacterium and streptomyces proteins) e.g. P71854|Rv3547|MTCY03C7.09c from Mycobacterium tuberculosis strain H37Rv (151 aa)%2C FASTA scores: opt: 310%2C E(): 2e-14%2C (40.5%25 identity in 116 aa overlap)%3B Q9ZH81 from M. paratuberculosis (144 aa)%2C FASTA scores: opt: 274%2C E(): 5.6e-12%2C (38.9%25 identity in 108 aa overlap)%3B O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa)%2C FASTA scores: opt: 235%2CE(): 2.7e-09%2C (35.2%25 identity in 108 aa overlap)%3B Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148 aa)%3B Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa)%3B etc. Equivalent to AAK47606 from Mycobacterium tuberculosis strain CDC1551 (171 aa) but shorter 52 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3178;product=Conserved hypothetical protein;protein_id=CCP45989.1;transl_table=11
AL123456.3	EMBL	gene	3547618	3548907	.	+	.	ID=gene-Rv3179;Name=Rv3179;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3179
AL123456.3	EMBL	CDS	3547618	3548907	.	+	0	ID=cds-CCP45990.1;Parent=gene-Rv3179;Dbxref=EnsemblGenomes-Gn:Rv3179,EnsemblGenomes-Tr:CCP45990,InterPro:IPR025420,InterPro:IPR027417,UniProtKB/TrEMBL:O53329,NCBI_GP:CCP45990.1;Name=CCP45990.1;Note=Rv3179%2C (MTV014.23)%2C len: 429 aa. Conserved protein%2Chighly similar to Q9KH61 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa)%2C FASTA scores: opt: 2466%2C E(): 1.5e-148%2C (89.7%25 identity in 428 aa overlap) (no article found on the NCBI web site (July 2001))%3B and to other hypothetical bacterial proteins e.g. O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411 aa)%2CFASTA scores: opt: 1031%2C E(): 8e-58%2C (41.5%25 identity in 417 aa overlap)%3B BAB54715|MLR9349 from Rhizobium loti (Mesorhizobium loti) (435 aa)%2C FASTA scores: opt: 365%2C E(): 1.1e-15%2C (31.75%25 identity in 416 aa overlap)%3B etc. Equivalent to AAK47609 from Mycobacterium tuberculosis strain CDC1551 (454 aa) but shorter 25 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3179;product=Conserved protein;protein_id=CCP45990.1;transl_table=11
AL123456.3	EMBL	gene	3549254	3549688	.	-	.	ID=gene-Rv3180c;Name=Rv3180c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3180c
AL123456.3	EMBL	CDS	3549254	3549688	.	-	0	ID=cds-CCP45991.1;Parent=gene-Rv3180c;Dbxref=EnsemblGenomes-Gn:Rv3180c,EnsemblGenomes-Tr:CCP45991,GOA:P9WF51,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP45991.1;Name=CCP45991.1;Note=Rv3180c%2C (MTV014.24c)%2C len: 144 aa. Hypothetical unknown ala-rich protein. Contains probable coiled-coil domain from aa 40 to 70. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv3180c;product=Hypothetical alanine rich protein;protein_id=CCP45991.1;transl_table=11
AL123456.3	EMBL	gene	3549691	3550143	.	-	.	ID=gene-Rv3181c;Name=Rv3181c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3181c
AL123456.3	EMBL	CDS	3549691	3550143	.	-	0	ID=cds-CCP45992.1;Parent=gene-Rv3181c;Dbxref=EnsemblGenomes-Gn:Rv3181c,EnsemblGenomes-Tr:CCP45992,GOA:P9WF15,InterPro:IPR006442,NCBI_GP:CCP45992.1;Name=CCP45992.1;Note=Rv3181c%2C (MTV014.25c)%2C len: 150 aa. Conserved protein%2C with some similarity to other mycobacterium proteins e.g. Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c (99 aa)%2C FASTA scores: opt: 123%2C E(): 0.25%2C (33.7%25 identity in 89 aa overlap)%3B and O50412|Rv3385c|MTV004.43c (102 aa)%2CFASTA scores: opt: 123%2C E(): 0.26%2C (39.7%25 identity in 68 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3181c;product=Conserved protein;protein_id=CCP45992.1;transl_table=11
AL123456.3	EMBL	gene	3550374	3550718	.	+	.	ID=gene-Rv3182;Name=Rv3182;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3182
AL123456.3	EMBL	CDS	3550374	3550718	.	+	0	ID=cds-CCP45993.1;Parent=gene-Rv3182;Dbxref=EnsemblGenomes-Gn:Rv3182,EnsemblGenomes-Tr:CCP45993,InterPro:IPR009241,UniProtKB/TrEMBL:O53332,NCBI_GP:CCP45993.1;Name=CCP45993.1;Note=Rv3182%2C (MTV014.26)%2C len: 114 aa. Hypothetical protein%2C with some similarity to other hypothetical bacterial proteins e.g. O53468|Rv2022c|MTV018.09c from M. tuberculosis (201 aa)%2C FASTA scores: opt: 335%2C E(): 3.6e-16%2C (51.9%25 identity in 104 aa overlap)%3B and Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119 aa)%2CFASTA scores: opt: 250%2C E(): 1.6e-10%2C (42.1%25 identity in 95 aa overlap). Equivalent to AAK47614 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but longer 20 aa. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3182;product=Conserved hypothetical protein;protein_id=CCP45993.1;transl_table=11
AL123456.3	EMBL	gene	3550715	3551044	.	+	.	ID=gene-Rv3183;Name=Rv3183;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3183
AL123456.3	EMBL	CDS	3550715	3551044	.	+	0	ID=cds-CCP45994.1;Parent=gene-Rv3183;Dbxref=EnsemblGenomes-Gn:Rv3183,EnsemblGenomes-Tr:CCP45994,GOA:O53333,InterPro:IPR001387,InterPro:IPR010982,UniProtKB/TrEMBL:O53333,NCBI_GP:CCP45994.1;Name=CCP45994.1;Note=Rv3183%2C (MTV014.27)%2C len: 109 aa. Possible transcriptional regulator%2C similar to others e.g. Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa)%2C FASTA scores: opt: 119%2C E(): 0.47%2C (40.55%25 identity in 74 aa overlap)%3B Q9X153|TM1330 from Thermotoga maritima (111 aa)%2CFASTA scores: opt: 115%2C E(): 0.91%2C (40.35%25 identity in 57 aa overlap)%3B P95258|Rv1956|MTCY09F9.08c (alias AAK46277 putative DNA-binding protein from strain CDC1551) (149 aa)%2CFASTA scores: opt: 116%2C E(): 1%2C (42.25%25 identity in 71 aa overlap). Also similar to O53467|Rv2021c|MTV018.08c from Mycobacterium tuberculosis (101 aa)%2C FASTA scores: opt: 214%2C E(): 5.8e-07%2C (43.0%25 identity in 107 aa overlap). Contains probable helix-turn-helix motif from aa 51 to 72 (Score 1803%2C +5.33 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv3183;product=Possible transcriptional regulatory protein;protein_id=CCP45994.1;transl_table=11
AL123456.3	EMBL	repeat_region	3551227	3551229	.	+	.	ID=id-AL123456.3:3551227..3551229;Note=3 bp direct repeat%2C cga%2C at 5'-end of IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	3551230	3552584	.	+	.	ID=id-AL123456.3:3551230..3552584;Note=IS6110-12%2C len: 1355 nt. Insertion sequence IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-12
AL123456.3	EMBL	repeat_region	3551230	3551257	.	+	.	ID=id-AL123456.3:3551230..3551257;Note=28 bp inverted repeat at left end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3551281	3551607	.	+	.	ID=gene-Rv3184;Name=Rv3184;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3184
AL123456.3	EMBL	CDS	3551281	3551607	.	+	0	ID=cds-CCP45995.1;Parent=gene-Rv3184;Dbxref=EnsemblGenomes-Gn:Rv3184,EnsemblGenomes-Tr:CCP45995,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP45995.1;Name=CCP45995.1;Note=Rv3184%2C (MTV014.28)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3184 and Rv3185%2Cthe sequence UUUUAAAG (directly upstream of Rv3185) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3184;product=Probable transposase for insertion sequence element IS6110 (fragment);protein_id=CCP45995.1;transl_table=11
AL123456.3	EMBL	gene	3551556	3552542	.	+	.	ID=gene-Rv3185;Name=Rv3185;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3185;partial=true;start_range=.,3551556
AL123456.3	EMBL	CDS	3551556	3552542	.	+	0	ID=cds-CCP45996.1;Parent=gene-Rv3185;Dbxref=EnsemblGenomes-Gn:Rv3185,EnsemblGenomes-Tr:CCP45996,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP45996.1;Name=CCP45996.1;Note=Rv3185%2C (MTV014.29)%2C len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3184 and Rv3185%2C the sequence UUUUAAAG (directly upstream of Rv3185) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 16 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3185;partial=true;product=Probable transposase;protein_id=CCP45996.1;start_range=.,3551556;transl_table=11
AL123456.3	EMBL	repeat_region	3552557	3552584	.	-	.	ID=id-AL123456.3:3552557..3552584;Note=28 bp inverted repeat at right end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3552585	3552587	.	+	.	ID=id-AL123456.3:3552585..3552587;Note=3 bp direct repeat%2C cga%2C at 3'-end of IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3552710	3552712	.	+	.	ID=id-AL123456.3:3552710..3552712;Note=3 bp direct repeat%2C att%2C at 5'-end of IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	3552713	3554067	.	+	.	ID=id-AL123456.3:3552713..3554067;Note=IS6110-13%2C len: 1355 nt. Insertion sequence IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-13
AL123456.3	EMBL	repeat_region	3552713	3552740	.	+	.	ID=id-AL123456.3:3552713..3552740;Note=28 bp inverted repeat at left end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3552764	3553090	.	+	.	ID=gene-Rv3186;Name=Rv3186;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3186
AL123456.3	EMBL	CDS	3552764	3553090	.	+	0	ID=cds-CCP45997.1;Parent=gene-Rv3186;Dbxref=EnsemblGenomes-Gn:Rv3186,EnsemblGenomes-Tr:CCP45997,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP45997.1;Name=CCP45997.1;Note=Rv3186%2C (MTV014.30)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3186 and Rv3187%2Cthe sequence UUUUAAAG (directly upstream of Rv3187) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3186;product=Probable transposase for insertion sequence element IS6110 (fragment);protein_id=CCP45997.1;transl_table=11
AL123456.3	EMBL	gene	3553039	3554025	.	+	.	ID=gene-Rv3187;Name=Rv3187;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3187;partial=true;start_range=.,3553039
AL123456.3	EMBL	CDS	3553039	3554025	.	+	0	ID=cds-CCP45998.1;Parent=gene-Rv3187;Dbxref=EnsemblGenomes-Gn:Rv3187,EnsemblGenomes-Tr:CCP45998,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP45998.1;Name=CCP45998.1;Note=Rv3187%2C (MTV014.31)%2C len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3186 and Rv3187%2C the sequence UUUUAAAG (directly upstream of Rv3187) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 16 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3187;partial=true;product=Probable transposase;protein_id=CCP45998.1;start_range=.,3553039;transl_table=11
AL123456.3	EMBL	repeat_region	3554040	3554067	.	-	.	ID=id-AL123456.3:3554040..3554067;Note=28 bp inverted repeat at right end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3554068	3554070	.	+	.	ID=id-AL123456.3:3554068..3554070;Note=3 bp direct repeat%2C att%2C at 5'-end of IS6110. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3554298	3554645	.	+	.	ID=gene-Rv3188;Name=Rv3188;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3188
AL123456.3	EMBL	CDS	3554298	3554645	.	+	0	ID=cds-CCP45999.1;Parent=gene-Rv3188;Dbxref=EnsemblGenomes-Gn:Rv3188,EnsemblGenomes-Tr:CCP45999,InterPro:IPR024467,UniProtKB/TrEMBL:O53334,NCBI_GP:CCP45999.1;Name=CCP45999.1;Note=Rv3188%2C (MTV014.32)%2C len: 115 aa. Conserved hypothetical protein%2C with similarity to other proteins from Mycobacterium tuberculosis: Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 hypothetical protein (113 aa)%2C FASTA scores: opt: 184%2C E(): 8.1e-06%2C(28.45%25 identity in 109 aa overlap)%3B and O06299|Rv0348|MTCY13E10.08 hypothetical protein (217 aa)%2CFASTA scores: opt: 129%2C E(): 0.074%2C (30.0%25 identity in 100 aa overlap). Also some similarity with C-terminus of Q9XA59|SCGD3.19 putative two-component system response transcriptional regulator from Streptomyces coelicolor (218 aa)%2C FASTA scores: opt: 114%2C E(): 0.76%2C (30.0%25 identity in 110 aa overlap) (for this one%2C no similarity exists in the N-terminal region with the N-terminus of other regulatory components of sensory transduction systems). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3188;product=Conserved hypothetical protein;protein_id=CCP45999.1;transl_table=11
AL123456.3	EMBL	gene	3554642	3555262	.	+	.	ID=gene-Rv3189;Name=Rv3189;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3189
AL123456.3	EMBL	CDS	3554642	3555262	.	+	0	ID=cds-CCP46000.1;Parent=gene-Rv3189;Dbxref=EnsemblGenomes-Gn:Rv3189,EnsemblGenomes-Tr:CCP46000,InterPro:IPR014914,UniProtKB/TrEMBL:O53335,NCBI_GP:CCP46000.1;Name=CCP46000.1;Note=Rv3189%2C (MTV014.33)%2C len: 206 aa. Conserved hypothetical protein%2C weakly similar to other proteins from Mycobacterium tuberculosis e.g. O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa)%2C FASTA scores: opt: 135%2C E(): 0.79%2C (27.8%25 identity in 187 aa overlap)%3B and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186 aa)%2CFASTA scores: opt: 122%2C E(): 0.85%2C (32.25%25 identity in 93 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3189;product=Conserved hypothetical protein;protein_id=CCP46000.1;transl_table=11
AL123456.3	EMBL	gene	3555422	3556687	.	-	.	ID=gene-Rv3190c;Name=Rv3190c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3190c
AL123456.3	EMBL	CDS	3555422	3556687	.	-	0	ID=cds-CCP46001.1;Parent=gene-Rv3190c;Dbxref=EnsemblGenomes-Gn:Rv3190c,EnsemblGenomes-Tr:CCP46001,GOA:O53336,UniProtKB/TrEMBL:O53336,NCBI_GP:CCP46001.1;Name=CCP46001.1;Note=Rv3190c%2C (MTV014.34c)%2C len: 421 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3190c;product=Hypothetical protein;protein_id=CCP46001.1;transl_table=11
AL123456.3	EMBL	gene	3556855	3557064	.	+	.	ID=gene-Rv3190A;Name=Rv3190A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3190A
AL123456.3	EMBL	CDS	3556855	3557064	.	+	0	ID=cds-CCP46002.1;Parent=gene-Rv3190A;Dbxref=EnsemblGenomes-Gn:Rv3190A,EnsemblGenomes-Tr:CCP46002,UniProtKB/TrEMBL:I6XGJ1,NCBI_GP:CCP46002.1;Name=CCP46002.1;Note=Rv3190A%2C len: 69 aa. Conserved protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3190A;product=Conserved protein;protein_id=CCP46002.1;transl_table=11
AL123456.3	EMBL	gene	3557311	3558345	.	-	.	ID=gene-Rv3191c;Name=Rv3191c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3191c
AL123456.3	EMBL	CDS	3557311	3558345	.	-	0	ID=cds-CCP46003.1;Parent=gene-Rv3191c;Dbxref=EnsemblGenomes-Gn:Rv3191c,EnsemblGenomes-Tr:CCP46003,GOA:O53337,InterPro:IPR001584,InterPro:IPR009057,InterPro:IPR012337,InterPro:IPR025246,UniProtKB/TrEMBL:O53337,NCBI_GP:CCP46003.1;Name=CCP46003.1;Note=Rv3191c%2C (MTV014.35c)%2C len: 344 aa. Probable transposase%2C similar to many especially Q9K2N8 putative transposase from Pseudomonas aeruginosa (338 aa)%2C FASTA scores: opt: 837%2C E(): 1.3e-43%2C (42.55%25 identity in 336 aa overlap)%3B Q9RBF4 insertion sequence IS1088 from Alcaligenes eutrophus (Ralstonia eutropha) (342 aa)%2C FASTA scores: opt: 823%2C E(): 9.2e-43%2C (43.05%25 identity in 337 aa overlap)%3B and Q51379 putative transposase from Pseudomonas alcaligenes (338 aa)%2C FASTA scores: opt: 818%2C E(): 1.8e-42%2C (42.35%25 identity in 333 aa overlap). Contains probable helix-turn-helix motif from aa 25 to 46 (Score 1968%2C +5.89 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3191c;product=Probable transposase;protein_id=CCP46003.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3557314	3558345	.	-	.	ID=id-Rv3191c;Note=IS1603%2C len: 1032 nt. Insertion sequence IS1603. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1603
AL123456.3	EMBL	gene	3559370	3559443	.	-	.	ID=gene-metU;Name=metU;gbkey=Gene;gene=metU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	3559370	3559443	.	-	.	ID=rna-metU;Parent=gene-metU;Note=codon recognized: AUG%3B metU%2C tRNA-fMet%2C anticodon cat%2C length %3D 74. Described in EM_BA: MTMETA Y08623 M.tuberculosis as metA gene. Name changed to metU as metA encodes homoserine transsuccinylase. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;anticodon=(pos:complement(3559407..3559409));gbkey=tRNA;gene=metU;product=tRNA-Met
AL123456.3	EMBL	exon	3559370	3559443	.	-	.	ID=exon-metU-1;Parent=rna-metU;Note=codon recognized: AUG%3B metU%2C tRNA-fMet%2C anticodon cat%2C length %3D 74. Described in EM_BA: MTMETA Y08623 M.tuberculosis as metA gene. Name changed to metU as metA encodes homoserine transsuccinylase. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;anticodon=(pos:complement(3559407..3559409));gbkey=tRNA;gene=metU;product=tRNA-Met
AL123456.3	EMBL	gene	3559563	3560024	.	+	.	ID=gene-Rv3192;Name=Rv3192;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3192
AL123456.3	EMBL	CDS	3559563	3560024	.	+	0	ID=cds-CCP46004.1;Parent=gene-Rv3192;Dbxref=EnsemblGenomes-Gn:Rv3192,EnsemblGenomes-Tr:CCP46004,GOA:O53338,InterPro:IPR011251,UniProtKB/TrEMBL:O53338,NCBI_GP:CCP46004.1;Name=CCP46004.1;Note=Rv3192%2C (MTV014.36)%2C len: 153 aa. Conserved hypothetical ala- and pro-rich protein%2C with weak similarity to N-terminal half of several proteins e.g. Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 hypothetical 37.3 KDA protein from Mycobacterium tuberculosis (340 aa)%2CFASTA scores: opt: 245%2C E(): 3.7e-08%2C (33.1%25 identity in 157 aa overlap)%3B O30260|AF2411 conserved hypothetical protein from Archaeoglobus fulgidus (363 aa)%2C FASTA scores: opt: 144%2C E(): 0.072%2C (32.6%25 identity in 92 aa overlap)%3B Q9ZA30|GRA-ORF29 putative FMN-dependent monooxygenase from Streptomyces violaceoruber (343 aa)%2C FASTA scores: opt: 133%2C E(): 0.33%2C (25.15%25 identity in 159 aa overlap).;gbkey=CDS;locus_tag=Rv3192;product=Conserved hypothetical alanine and proline-rich protein;protein_id=CCP46004.1;transl_table=11
AL123456.3	EMBL	gene	3560194	3563172	.	-	.	ID=gene-Rv3193c;Name=Rv3193c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3193c
AL123456.3	EMBL	CDS	3560194	3563172	.	-	0	ID=cds-CCP46005.1;Parent=gene-Rv3193c;Dbxref=EnsemblGenomes-Gn:Rv3193c,EnsemblGenomes-Tr:CCP46005,GOA:P9WFL3,InterPro:IPR005372,NCBI_GP:CCP46005.1;Name=CCP46005.1;Note=Rv3193c%2C (MTV014.37c)%2C len: 992 aa. Probable conserved transmembrane protein%2C with hydrophobic N-terminal domain (~~1-340 aa)%2C highly similar to Q9CCM6|ML0644 putative integral membrane protein from Mycobacterium leprae (983 aa)%2C FASTA scores: opt: 5421%2CE(): 0%2C (86.15%25 identity in 989 aa overlap)%3B and O53609|Rv0064|MTV030.07 putative membrane protein from Mycobacterium tuberculosis strain H37Rv (979 aa)%2C FASTA scores: opt: 3204%2C E(): 2.1e-142%2C (50.25%25 identity in 985 aa overlap). C-terminal part (709-990 aa) highly similar to O32904|MLCB1779.46 hypothetical 29.1 KDA protein from Mycobacterium leprae (277 aa)%2C FASTA scores: opt: 1521%2CE(): 3.4e-64%2C (82.6%25 identity in 282 aa overlap). Also some similarity to hypothetical proteins generally transmembrane e.g. Q9FCI4|2SC3B6.28 from Streptomyces coelicolor (815 aa)%2C FASTA scores: opt: 951%2C E(): 3.4e-37%2C (39.2%25 identity in 826 aa overlap)%3B P72637|SLL1060 from Synechocystis sp. strain PCC 6803 (1032 aa)%2C FASTA scores: opt: 938%2C E(): 1.6e-36%2C (29.95%25 identity in 855 aa overlap)%3B O28851|AF1421 from Archaeoglobus fulgidus (880 aa)%2C FASTA scores: opt: 526%2C E(): 2.6e-17%2C (28.05%25 identity in 970 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3193c;product=Probable conserved transmembrane protein;protein_id=CCP46005.1;transl_table=11
AL123456.3	EMBL	gene	3563264	3564286	.	-	.	ID=gene-Rv3194c;Name=Rv3194c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3194c
AL123456.3	EMBL	CDS	3563264	3564286	.	-	0	ID=cds-CCP46006.1;Parent=gene-Rv3194c;Dbxref=EnsemblGenomes-Gn:Rv3194c,EnsemblGenomes-Tr:CCP46006,GOA:O53340,InterPro:IPR001478,InterPro:IPR008269,InterPro:IPR014721,InterPro:IPR020568,InterPro:IPR027065,UniProtKB/TrEMBL:O53340,NCBI_GP:CCP46006.1;Name=CCP46006.1;Note=Rv3194c%2C (MTV014.38c)%2C len: 340 aa. Possible conserved secreted protein (N-terminal stretch hydrophobic)%2C equivalent to Q9CCM7|ML0643 putative secreted protein from Mycobacterium leprae (340 aa)%2C FASTA scores: opt: 1822%2C E(): 1.6e-102%2C (80.3%25 identity in 340 aa overlap). Also similar to other proteins e.g. Q9FCI6|2SC3B6.26 putative secreted protein from Streptomyces coelicolor (364 aa)%2C FASTA scores: opt: 430%2CE(): 1.1e-18%2C (40.95%25 identity in 359 aa overlap)%3B Q9S3Y5|SDRC SDRC protein from Streptomyces coelicolor (241 aa)%2C FASTA scores: opt: 396%2C E(): 8.9e-17%2C (35.2%25 identity in 318 aa overlap) (similarity in part for this one)%3B O34470|YLBL YLBL protein from Bacillus subtilis (350 aa)%2CFASTA scores: opt: 385%2C E(): 5.6e-16%2C (27.7%25 identity in 350 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3194c;product=Possible conserved secreted protein;protein_id=CCP46006.1;transl_table=11
AL123456.3	EMBL	gene	3564364	3565782	.	+	.	ID=gene-Rv3195;Name=Rv3195;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3195
AL123456.3	EMBL	CDS	3564364	3565782	.	+	0	ID=cds-CCP46007.1;Parent=gene-Rv3195;Dbxref=EnsemblGenomes-Gn:Rv3195,EnsemblGenomes-Tr:CCP46007,InterPro:IPR018766,UniProtKB/TrEMBL:O53341,NCBI_GP:CCP46007.1;Name=CCP46007.1;Note=Rv3195%2C (MTV014.39)%2C len: 472 aa. Hypothetical protein%2C equivalent to Q49746|ML0642|B1937_C3_231 hypothetical 50.3 KDA protein from Mycobacterium leprae (479 aa)%2C FASTA scores: opt: 2503%2C E(): 1e-138%2C (79.35%25 identity in 475 aa overlap). Similar in part to Q9FCI9|2SC3B6.23c conserved hypothetical protein from Streptomyces coelicolor (487 aa)%2C FASTA scores: opt: 1382%2CE(): 2.7e-73%2C (46.4%25 identity in 489 aa overlap)%3B Q9X8I7|SCE9.14 hypothetical 41.2 KDA protein from Streptomyces coelicolor (375 aa)%2C FASTA scores: opt: 319%2CE(): 2.4e-11%2C (25.6%25 identity in 383 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3195;product=Conserved hypothetical protein;protein_id=CCP46007.1;transl_table=11
AL123456.3	EMBL	gene	3565788	3566687	.	+	.	ID=gene-Rv3196;Name=Rv3196;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3196
AL123456.3	EMBL	CDS	3565788	3566687	.	+	0	ID=cds-CCP46008.1;Parent=gene-Rv3196;Dbxref=EnsemblGenomes-Gn:Rv3196,EnsemblGenomes-Tr:CCP46008,UniProtKB/TrEMBL:O53342,NCBI_GP:CCP46008.1;Name=CCP46008.1;Note=Rv3196%2C (MTV014.40)%2C len: 299 aa. Hypothetical protein%2C with some similarity to other hypothetical proteins e.g. Q9FCJ5|2SC3B6.17c putative secreted protein from Streptomyces coelicolor (442 aa)%2C FASTA scores: opt: 233%2C E(): 3.5e-07%2C (29.9%25 identity in 261 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;locus_tag=Rv3196;product=Conserved hypothetical protein;protein_id=CCP46008.1;transl_table=11
AL123456.3	EMBL	gene	3566696	3566896	.	-	.	ID=gene-Rv3196A;Name=Rv3196A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3196A
AL123456.3	EMBL	CDS	3566696	3566896	.	-	0	ID=cds-CCP46009.1;Parent=gene-Rv3196A;Dbxref=EnsemblGenomes-Gn:Rv3196A,EnsemblGenomes-Tr:CCP46009,UniProtKB/TrEMBL:L7N668,NCBI_GP:CCP46009.1;Name=CCP46009.1;Note=Rv3196A%2C len: 66 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3196A;product=Unknown protein;protein_id=CCP46009.1;transl_table=11
AL123456.3	EMBL	gene	3567024	3568367	.	+	.	ID=gene-Rv3197;Name=Rv3197;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3197
AL123456.3	EMBL	CDS	3567024	3568367	.	+	0	ID=cds-CCP46010.1;Parent=gene-Rv3197;Dbxref=EnsemblGenomes-Gn:Rv3197,EnsemblGenomes-Tr:CCP46010,GOA:O53343,InterPro:IPR002575,InterPro:IPR004147,InterPro:IPR011009,UniProtKB/TrEMBL:O53343,NCBI_GP:CCP46010.1;Name=CCP46010.1;Note=Rv3197%2C (MTV014.41)%2C len: 447 aa. Probable conserved ATP-binding protein ABC transporter%2C highly similar to Mycobacterium leprae proteins: Q9CCM8|ML0640 hypothetical protein (473 aa)%2C FASTA scores: opt: 2512%2C E(): 2.1e-140%2C(83.0%25 identity in 447 aa overlap). Interestingly%2C the N-terminal half (1-219 aa) corresponds to Q49747|ABC1|B1937_C3_233 ABC1 protein from Mycobacterium leprae (267 aa)%2C FASTA scores: opt: 1276%2C E(): 6.3e-68%2C(88.6%25 identity in 219 aa overlap)%3B and the C-terminal half (239-447 aa) corresponds to Q49745|B1937_C2_179 hypothetical 23.1 KDA protein (206 aa)%2C FASTA scores: opt: 1138%2C E(): 6.5e-60%2C (77.05%25 identity in 209 aa overlap)%3B two adjacent orfs from Mycobacterium leprae. Also highly similar to other proteins (generally ABC transporters) e.g. Q9FCJ6|2SC3B6.16c hypothetical 51.3 KDA protein from Streptomyces coelicolor (469 aa)%2C FASTA scores: opt: 1340%2CE(): 1.8e-71%2C (45.9%25 identity in 449 aa overlap)%3B O65576|ABC1AT ABC1 protein (alias Q9SBB2|T15B16.14|AT4G01660 putative ABC transporter) from Arabidopsis thaliana (Mouse-ear cress) (623 aa)%2C FASTA scores: opt: 543%2C E(): 1.7e-24%2C (28.4%25 identity in 405 aa overlap)%3B O27682|MTH1645 ABC transporter from Methanobacterium thermoautotrophicum (623 aa)%2C FASTA scores: opt: 497%2C E(): 7.8e-22%2C (33.0%25 identity in 309 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3197;product=Probable conserved ATP-binding protein ABC transporter;protein_id=CCP46010.1;transl_table=11
AL123456.3	EMBL	gene	3568401	3568679	.	-	.	ID=gene-Rv3197A;Name=whiB7;gbkey=Gene;gene=whiB7;gene_biotype=protein_coding;gene_synonym=whmC;locus_tag=Rv3197A
AL123456.3	EMBL	CDS	3568401	3568679	.	-	0	ID=cds-CCP46011.1;Parent=gene-Rv3197A;Dbxref=EnsemblGenomes-Gn:Rv3197A,EnsemblGenomes-Tr:CCP46011,GOA:Q6MX01,InterPro:IPR003482,InterPro:IPR017956,NCBI_GP:CCP46011.1;Name=CCP46011.1;Note=Rv3197A%2C len: 92 aa. Probable whiB7 (alternate gene name: whmC)%2C WhiB-like regulatory protein (see citation below)%2C similar to WhiB paralogue of Streptomyces coelicolor%2C wblE gene product (85 aa). Equivalent to Q49765|WHIB7|ML0639|B1937_F2_68 putative transcriptional regulator WHIB7 from Mycobacterium leprae (89 aa)%2C FASTA scores: opt: 441%2C E(): 6.3e-24%2C (69.3%25 identity in 88 aa overlap). Similar to Q9FCJ8|2SC3B6.14 putative DNA-binding protein from Streptomyces coelicolor (122 aa)%2C FASTA scores: opt: 348%2C E(): 2.2e-17%2C (57.7%25 identity in 78 aa overlap)%3B Q9AD55|SCP1.95 putative regulatory protein from Streptomyces coelicolor (102 aa)%2C FASTA scores: opt: 166%2CE(): 7.1e-05%2C (39.4%25 identity in 76 aa overlap)%3B etc.;gbkey=CDS;gene=whiB7;locus_tag=Rv3197A;product=Probable transcriptional regulatory protein WhiB-like WhiB7;protein_id=CCP46011.1;transl_table=11
AL123456.3	EMBL	gene	3569109	3571211	.	-	.	ID=gene-Rv3198c;Name=uvrD2;gbkey=Gene;gene=uvrD2;gene_biotype=protein_coding;locus_tag=Rv3198c
AL123456.3	EMBL	CDS	3569109	3571211	.	-	0	ID=cds-CCP46012.1;Parent=gene-Rv3198c;Dbxref=EnsemblGenomes-Gn:Rv3198c,EnsemblGenomes-Tr:CCP46012,GOA:P9WMP9,InterPro:IPR000212,InterPro:IPR002121,InterPro:IPR010997,InterPro:IPR014016,InterPro:IPR014017,InterPro:IPR027417,NCBI_GP:CCP46012.1;Name=CCP46012.1;Note=Rv3198c%2C (MTV014.42c)%2C len: 700 aa. Probable UvrD2%2CATP dependent DNA helicase II (see citation below)%2Cequivalent to P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 probable DNA helicase II homolog from Mycobacterium leprae (717 aa)%2CFASTA scores: opt: 3749%2C E(): 0%2C (82.85%25 identity in 706 aa overlap)%3B and C-terminal half (466-700 aa) corresponds to Q49764|RECQ|B1937_F2_66 putative DNA helicase RECQ (242 aa)%2C FASTA scores: opt: 1267%2C E(): 1.4e-69%2C (82.5%25 identity in 234 aa overlap)%3B products of two adjacent ORFS in Mycobacterium leprae. Also similar to other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces coelicolor (785 aa)%2C FASTA scores: opt: 1687%2C E(): 1.2e-94%2C (52.05%25 identity in 728 aa overlap)%3B P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-dependent DNA helicase PCRA from Mycobacterium tuberculosis (771 aa)%2CFASTA scores: opt: 715%2C E(): 1e-35%2C (34.1%25 identity in 710 aa overlap)%3B Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-dependent DNA helicase PCRA from Mycobacterium leprae (778 aa)%2C FASTA scores: opt: 687%2C E(): 5.1e-34%2C (32.0%25 identity in 719 aa overlap)%3B O83991|TP1028 DNA helicase II (UVRD) from Treponema pallidum (670 aa)%2C FASTA scores: opt: 652%2C E(): 6e-32%2C (30.25%25 identity in 671 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the UVRD subfamily of helicases.;gbkey=CDS;gene=uvrD2;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3198c;product=Probable ATP-dependent DNA helicase II UvrD2;protein_id=CCP46012.1;transl_table=11
AL123456.3	EMBL	gene	3571335	3571589	.	+	.	ID=gene-Rv3198A;Name=Rv3198A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3198A
AL123456.3	EMBL	CDS	3571335	3571589	.	+	0	ID=cds-CCP46013.1;Parent=gene-Rv3198A;Dbxref=EnsemblGenomes-Gn:Rv3198A,EnsemblGenomes-Tr:CCP46013,GOA:P9WN17,InterPro:IPR002109,InterPro:IPR011915,InterPro:IPR012336,PDB:2LQO,PDB:2LQQ,NCBI_GP:CCP46013.1;Name=CCP46013.1;Note=Rv3198A%2C len: 84 aa. Possible glutaredoxin protein %2Chighly similar to Q9FCK1|2SC3B6.11c putative glutaredoxin-like protein from Streptomyces coelicolor (80 aa)%2C FASTA scores: opt: 293%2C E(): 2.2e-14%2C (55.15%25 identity in 78 aa overlap)%3B and Q9RSN9|DR2085 putative glutaredoxin from Deinococcus radiodurans (81 aa)%2C FASTA scores: opt: 198%2C E(): 1.2e-07%2C (53.55%25 identity in 56 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9X8C2|SCE36.09 hypothetical 13.0 KDA protein from Streptomyces coelicolor (114 aa)%2C FASTA scores: opt: 181%2CE(): 2.6e-06%2C (44.45%25 identity in 72 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3198A;product=Possible glutaredoxin protein;protein_id=CCP46013.1;transl_table=11
AL123456.3	EMBL	gene	3571602	3572543	.	-	.	ID=gene-Rv3199c;Name=nudC;gbkey=Gene;gene=nudC;gene_biotype=protein_coding;locus_tag=Rv3199c
AL123456.3	EMBL	CDS	3571602	3572543	.	-	0	ID=cds-CCP46014.1;Parent=gene-Rv3199c;Dbxref=EnsemblGenomes-Gn:Rv3199c,EnsemblGenomes-Tr:CCP46014,GOA:P9WIX5,InterPro:IPR000086,InterPro:IPR015375,InterPro:IPR015376,InterPro:IPR015797,InterPro:IPR020084,InterPro:IPR022925,NCBI_GP:CCP46014.1;Name=CCP46014.1;Note=Rv3199c%2C (MTV014.43)c%2C len: 313 aa. Probable nudC%2CNADH pyrophosphatase%2C similar in particular to Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa)%2CFASTA scores: opt: 493%2C E(): 7.4e-24%2C (39.65%25 identity in 232 aa overlap)%3B Q9ABG1|CC0266 mutt/NUDIX family protein from Caulobacter crescentus (313 aa)%2C FASTA scores: opt: 479%2C E(): 5.1e-23%2C (38.3%25 identity in 222 aa overlap)%3B O86062|NUDC_PSEAE|NUDC|PA1823 NADH pyrophosphatase from Pseudomonas aeruginosa (278 aa)%2C FASTA scores: opt: 371%2C2 E(): 3e-16%2C (43.15%25 identity in 153 aa overlap)%3B Q9RV62|NUDC_DEIRA|NUDC|DR1168 NADH pyrophosphatase from Deinococcus radiodurans (280 aa)%2C FASTA scores: opt: 363%2CE(): 9.6e-16%2C (34.45%25 identity in 270 aa overlap)%3B etc. Caution: equivalent to AAK47636 from Mycobacterium tuberculosis strain CDC1551 (386 aa) but shorter 72 aa. Contains PS00893 mutT domain signature. Belongs to the NUDIX hydrolase family%2C NUDC subfamily. Cofactor: requires divalent ions: manganese or magnesium.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nudC;inference=protein motif:PROSITE:PS00893;locus_tag=Rv3199c;product=Probable NADH pyrophosphatase NudC (NAD+ diphosphatase) (NAD+ pyrophosphatase) (NADP pyrophosphatase);protein_id=CCP46014.1;transl_table=11
AL123456.3	EMBL	gene	3572602	3573669	.	-	.	ID=gene-Rv3200c;Name=Rv3200c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3200c
AL123456.3	EMBL	CDS	3572602	3573669	.	-	0	ID=cds-CCP46015.1;Parent=gene-Rv3200c;Dbxref=EnsemblGenomes-Gn:Rv3200c,EnsemblGenomes-Tr:CCP46015,GOA:O53346,InterPro:IPR003148,InterPro:IPR013099,InterPro:IPR016040,UniProtKB/TrEMBL:O53346,NCBI_GP:CCP46015.1;Name=CCP46015.1;Note=Rv3200c%2C (MTV014.44c)%2C len: 355 aa. Possible transmembrane cation transporter%2C similar to many transmembrane proteins and putative potassium channels e.g. Q9XA52|SCGD3.27C putative membrane protein from Streptomyces coelicolor (365 aa)%2C FASTA scores: opt: 1022%2CE(): 2.6e-53%2C (49.85%25 identity in 325 aa overlap)%3B Q9RRZ3|DR2336 putative potassium channel from Deinococcus radiodurans (320 aa)%2C FASTA scores: opt: 436%2C E(): 1e-18%2C(30.9%25 identity in 304 aa overlap)%3B O28600|AF1673 putative potassium channel from Archaeoglobus fulgidus (314 aa)%2CFASTA scores: opt: 363%2C E(): 2.1e-14%2C (27.2%25 identity in 309 aa overlap)%3B Q57604|Y13B_METJAMJ0138.1|MJ0138.1 putative potassium channel from Methanococcus jannaschii (333 aa)%2C FASTA scores: opt: 356%2C E(): 5.7e-14%2C (26.0%25 identity in 281 aa overlap)%3B P73132|SLL0993 potassium channel from Synechocystis sp. strain PCC 6803 (365 aa)%2CFASTA scores: opt: 330%2C E(): 2.1e-12%2C (27.8%25 identity in 324 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3200c;product=Possible transmembrane cation transporter;protein_id=CCP46015.1;transl_table=11
AL123456.3	EMBL	gene	3573731	3577036	.	-	.	ID=gene-Rv3201c;Name=Rv3201c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3201c
AL123456.3	EMBL	CDS	3573731	3577036	.	-	0	ID=cds-CCP46016.1;Parent=gene-Rv3201c;Dbxref=EnsemblGenomes-Gn:Rv3201c,EnsemblGenomes-Tr:CCP46016,GOA:O53347,InterPro:IPR000212,InterPro:IPR011335,InterPro:IPR014016,InterPro:IPR014017,InterPro:IPR027417,UniProtKB/TrEMBL:O53347,NCBI_GP:CCP46016.1;Name=CCP46016.1;Note=Rv3201c%2C (MTV014.45c)%2C len: 1101 aa. Probable ATP-dependent DNA helicase%2C similar to others e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 aa)%2CFASTA scores: opt: 1209%2C E(): 5.4e-63%2C (38.45%25 identity in 1199 aa overlap)%3B P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from Mycobacterium tuberculosis (771 aa)%2C FASTA scores: opt: 403%2C E(): 6.5e-16%2C (28.15%25 identity in 717 aa overlap)%3B Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa)%2CFASTA scores: opt: 349%2C E(): 1.3e-12%2C (29.2%25 identity in 1144 aa overlap)%3B Q9L3M1|UVRD from Prochlorococcus sp. (512 aa%3B fragment)%2C FASTA scores: opt: 290%2C E(): 2e-09%2C (27.95%25 identity in 479 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3201c;product=Probable ATP-dependent DNA helicase;protein_id=CCP46016.1;transl_table=11
AL123456.3	EMBL	gene	3577033	3580200	.	-	.	ID=gene-Rv3202c;Name=Rv3202c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3202c
AL123456.3	EMBL	CDS	3577033	3580200	.	-	0	ID=cds-CCP46017.1;Parent=gene-Rv3202c;Dbxref=EnsemblGenomes-Gn:Rv3202c,EnsemblGenomes-Tr:CCP46017,GOA:O53348,InterPro:IPR000212,InterPro:IPR014016,InterPro:IPR014017,InterPro:IPR027417,UniProtKB/TrEMBL:O53348,NCBI_GP:CCP46017.1;Name=CCP46017.1;Note=Rv3202c%2C (MTCY07D11.24%2C MTV014.46c)%2C len: 1055 aa. Possible ATP-dependent DNA helicase%2C showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 putative ATP-dependent DNA helicase from Streptomyces coelicolor (1159 aa)%2C FASTA scores: opt: 666%2C E(): 1e-29%2C (34.5%25 identity in 1154 aa overlap)%3B Q9L7T3|UVRD|PA5443 mismatch repair protein MUTU (DNA helicase II) from Pseudomonas aeruginosa (728 aa)%2C FASTA scores: opt: 239%2C E(): 7.3e-06%2C(23.8%25 identity in 677 aa overlap) (no similarity in C-terminal part for this one)%3B etc. C-terminal region similar to Q9FDU2|ORF3 ORF3 protein (fragment) from Streptomyces griseus (551 aa)%2C FASTA scores: opt: 800%2C E(): 1.7e-37%2C (36.2%25 identity in 525 aa overlap)%3B and Q9ZG15 hypothetical 35.5 KDA protein from Rhodococcus erythropolis (323 aa)%2C FASTA scores: opt: 232%2C E(): 9.7e-06%2C (28.55%25 identity in 266 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3202c;product=Possible ATP-dependent DNA helicase;protein_id=CCP46017.1;transl_table=11
AL123456.3	EMBL	gene	3580638	3581312	.	+	.	ID=gene-Rv3203;Name=lipV;gbkey=Gene;gene=lipV;gene_biotype=protein_coding;locus_tag=Rv3203
AL123456.3	EMBL	CDS	3580638	3581312	.	+	0	ID=cds-CCP46018.1;Parent=gene-Rv3203;Dbxref=EnsemblGenomes-Gn:Rv3203,EnsemblGenomes-Tr:CCP46018,GOA:L0TC47,InterPro:IPR000073,InterPro:IPR000639,InterPro:IPR029058,UniProtKB/TrEMBL:L0TC47,NCBI_GP:CCP46018.1;Name=CCP46018.1;Note=Rv3203%2C (MTCY07D11.23c)%2C len: 224 aa. Possible lipV%2Chydrolase lipase%2C showing some similarity to other lipases e.g. Q9JSN0|NMA2216 putative hydrolase from Neisseria meningitidis (serogroup A) (312 aa)%2C FASTA scores: opt: 192%2C E(): 0.00016%2C (45.2%25 identity in 73 aa overlap)%3B Q9RK95|SCF1.09 putative hydrolase from Streptomyces coelicolor (258 aa)%2C FASTA scores: opt: 188%2C E(): 0.00024%2C(30.1%25 identity in 226 aa overlap)%3B Q9KZC3|SC6F7.19c putative lipase from Streptomyces coelicolor (269 aa)%2CFASTA scores: opt: 179%2C E(): 0.00086%2C (36.35%25 identity in 121 aa overlap)%3B etc. Equivalent to AAK47641 Hydrolase%2Calpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 (261 aa) but shorter 37 aa. Contains serine active site signature of lipases (PS00120).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipV;inference=protein motif:PROSITE:PS00120;locus_tag=Rv3203;product=Possible lipase LipV;protein_id=CCP46018.1;transl_table=11
AL123456.3	EMBL	gene	3581315	3581620	.	+	.	ID=gene-Rv3204;Name=Rv3204;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3204
AL123456.3	EMBL	CDS	3581315	3581620	.	+	0	ID=cds-CCP46019.1;Parent=gene-Rv3204;Dbxref=EnsemblGenomes-Gn:Rv3204,EnsemblGenomes-Tr:CCP46019,GOA:O05862,InterPro:IPR011991,InterPro:IPR014048,UniProtKB/TrEMBL:O05862,NCBI_GP:CCP46019.1;Name=CCP46019.1;Note=Rv3204%2C (MTCY07D11.22c)%2C len: 101 aa. Possible DNA methyltransferase%2C similar to many hypothetical bacteriel proteins and methyltransferases e.g. Q9KT40|VC1065 methylated-DNA--protein-cysteine methyltransferase-related protein from Vibrio cholerae (100 aa)%2C FASTA scores: opt: 170%2C E(): 2.8e-05%2C (34.35%25 identity in 99 aa overlap)%3B Q9UTN9|SPAC1250.04c putative methyltransferase from Schizosaccharomyces pombe (Fission yeast) (108 aa)%2C FASTA scores: opt: 161%2C E(): 0.00013%2C (36.65%25 identity in 101 aa overlap)%3B Q9YDF4|APE0959 175 AA long hypothetical methylated-DNA--protein-cysteine methyltransferase from Aeropyrum pernix (175 aa)%2C FASTA scores: opt: 144%2C E(): 0.003%2C (37.95%25 identity in 87 aa overlap)%3B Q50855 putative methylguanine-DNA methyltransferase from Myxococcus xanthus (147 aa)%2C FASTA scores: opt: 141%2C E(): 0.0041%2C (37.65%25 identity in 93 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3204;product=Possible DNA-methyltransferase (modification methylase);protein_id=CCP46019.1;transl_table=11
AL123456.3	EMBL	gene	3581627	3582505	.	-	.	ID=gene-Rv3205c;Name=Rv3205c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3205c
AL123456.3	EMBL	CDS	3581627	3582505	.	-	0	ID=cds-CCP46020.1;Parent=gene-Rv3205c;Dbxref=EnsemblGenomes-Gn:Rv3205c,EnsemblGenomes-Tr:CCP46020,GOA:O05861,InterPro:IPR013402,UniProtKB/TrEMBL:O05861,NCBI_GP:CCP46020.1;Name=CCP46020.1;Note=Rv3205c%2C (MTCY07D11.21)%2C len: 292 aa. Conserved protein%2C highly similar to Q9CCG7|ML0818 hypothetical protein from Mycobacterium leprae (297 aa)%2C FASTA scores: opt: 1745%2C E(): 9.1e-98%2C (87.3%25 identity in 291 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3205c;product=Conserved protein;protein_id=CCP46020.1;transl_table=11
AL123456.3	EMBL	gene	3582532	3583710	.	-	.	ID=gene-Rv3206c;Name=moeB1;gbkey=Gene;gene=moeB1;gene_biotype=protein_coding;gene_synonym=moeZ;locus_tag=Rv3206c
AL123456.3	EMBL	CDS	3582532	3583710	.	-	0	ID=cds-CCP46021.1;Parent=gene-Rv3206c;Dbxref=EnsemblGenomes-Gn:Rv3206c,EnsemblGenomes-Tr:CCP46021,GOA:P9WMN7,InterPro:IPR000594,InterPro:IPR001763,InterPro:IPR007901,InterPro:IPR009036,InterPro:IPR016040,NCBI_GP:CCP46021.1;Name=CCP46021.1;Note=Rv3206c%2C (MTCY07D11.20)%2C len: 392 aa. Probable moeB1%2C molybdopterin cofactor biosynthesis protein%2Cequivalent to Q9CCG8|MOEZ|ML0817 protein probably involved in molybdopterin biosynthesis from Mycobacterium leprae (395 aa)%2C FASTA scores: opt: 2285%2C E(): 3.3e-130%2C (86.45%25 identity in 391 aa overlap.) Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 putative sulfurylase from Streptomyces coelicolor (392 aa)%2C FASTA scores: opt: 1776%2C E(): 1.4e-99%2C (65.3%25 identity in 395 aa overlap)%3B Q9XC37|PDTORFF MOEB-like protein (putative sulfurylase) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa)%2C FASTA scores: opt: 1526%2C E(): 1.5e-84%2C (59.1%25 identity in 391 aa overlap)%3B O54307|MPT|MOEB MPT-synthase sulfurylase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa)%2C FASTA scores: opt: 1309%2C E(): 1.8e-71%2C (52.95%25 identity in 387 aa overlap)%3B P74344|MOEB|SLL1536 molybdopterin biosynthesis MOEB protein from Synechocystis sp. strain PCC 6803 (392 aa)%2C FASTA scores: opt: 1308%2C E(): 2e-71%2C (50.65%25 identity in 397 aa overlap)%3B etc. Also highly similar to O05792|MOEB2|Rv3116|MTCY164.26 putative molybdenum cofactor biosynthesis protein from Mycobacterium tuberculosis (389 aa)%2C FASTA scores: opt: 1440%2C E(): 2.3e-79%2C (57.25%25 identity in 386 aa overlap). Has hydrophobic segment from ~~45-71. Belongs to the HesA/MoeB/ThiF FAMILY. Note that previously known as moeZ. Thought to be differentially expressed within host cells (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moeB1;locus_tag=Rv3206c;product=Probable molybdenum cofactor biosynthesis protein MoeB1 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase);protein_id=CCP46021.1;transl_table=11
AL123456.3	EMBL	gene	3583801	3584658	.	-	.	ID=gene-Rv3207c;Name=Rv3207c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3207c
AL123456.3	EMBL	CDS	3583801	3584658	.	-	0	ID=cds-CCP46022.1;Parent=gene-Rv3207c;Dbxref=EnsemblGenomes-Gn:Rv3207c,EnsemblGenomes-Tr:CCP46022,GOA:O05859,InterPro:IPR006026,InterPro:IPR022603,InterPro:IPR024079,UniProtKB/TrEMBL:O05859,NCBI_GP:CCP46022.1;Name=CCP46022.1;Note=Rv3207c%2C (MTCY07D11.19)%2C len: 285 aa. Conserved protein%2C highly similar but shorter (57 aa) to Q9CCG9|ML0816 hypothetical protein from Mycobacterium leprae (341 aa)%2C FASTA scores: opt: 1676%2C E(): 9.7e-96%2C(81.0%25 identity in 284 aa overlap). Also similar to C-terminus of Q9FBI6|SCP8.36 hypothetical protein from Streptomyces coelicolor (559 aa)%2C FASTA scores: opt: 426%2CE(): 8.4e-19%2C (37.35%25 identity in 281 aa overlap)%3B and similar to other hypothetical proteins (generally membrane proteins) e.g. Q9K456|SC2H12.28C putative membrane protein from Streptomyces coelicolor (314 aa)%2C FASTA scores: opt: 341%2C E(): 8.8e-14%2C (29.75%25 identity in 296 aa overlap). Contains neutral zinc metallopeptidases%2C zinc-binding region signature (PS00142).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv3207c;product=Conserved protein;protein_id=CCP46022.1;transl_table=11
AL123456.3	EMBL	gene	3585004	3585690	.	+	.	ID=gene-Rv3208;Name=Rv3208;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3208
AL123456.3	EMBL	CDS	3585004	3585690	.	+	0	ID=cds-CCP46023.1;Parent=gene-Rv3208;Dbxref=EnsemblGenomes-Gn:Rv3208,EnsemblGenomes-Tr:CCP46023,GOA:O05858,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,UniProtKB/TrEMBL:O05858,NCBI_GP:CCP46023.1;Name=CCP46023.1;Note=Rv3208%2C (MTCY07D11.18c)%2C len: 228 aa. Probable transcriptional regulator%2C TetR family%2C equivalent to Q9CCH0|ML0815 putative TetR-family transcriptional regulator from Mycobacterium leprae (228 aa)%2C FASTA scores: opt: 1248%2C E(): 1.4e-74%2C (82.4%25 identity in 227 aa overlap). Also highly similar to Q9FBI8|SCP8.33c putative TetR-family transcriptional regulator from Streptomyces coelicolor (213 aa)%2C FASTA scores: opt: 629%2C E(): 4e-34%2C(45.8%25 identity in 203 aa overlap)%3B Q9KIL9|F58R F58R (fragment) from Streptomyces coelicolor A3(2) (149 aa)%2CFASTA scores: opt: 497%2C E(): 1.3e-25%2C (50.35%25 identity in 147 aa overlap)%3B Q9K3T5|SCE66.08 putative TetR-family transcriptional regulator from Streptomyces coelicolor (225 aa)%2C FASTA scores: opt: 344%2C E(): 1.8e-15%2C (31.15%25 identity in 212 aa overlap)%3B Q9RYK4|DRA0308 transcriptional regulator%2C TetR family from Deinococcus radiodurans (239 aa)%2C FASTA scores: opt: 290%2C E(): 6.5e-12%2C (30.5%25 identity in 223 aa overlap)%3B etc. And also similar to Mycobacterium tuberculosis proteins P96381|Rv1019|MTCY10G2.30c hypothetical 21.7 KDA protein (197 aa)%2C FASTA scores: opt: 356%2C E(): 2.7e-16%2C (34.4%25 identity in 189 aa overlap)%3B MTV034_4%3B MTY07A7A_3%3B MTV032_1%3B MTCY07A7_12%3B etc. Contains probable helix-turn-helix motif at aa 60-81 (Score 1517%2C+4.35 SD). Similar to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3208;product=Probable transcriptional regulatory protein (probably TetR-family);protein_id=CCP46023.1;transl_table=11
AL123456.3	EMBL	gene	3585677	3585949	.	-	.	ID=gene-Rv3208A;Name=TB9.4;gbkey=Gene;gene=TB9.4;gene_biotype=protein_coding;locus_tag=Rv3208A
AL123456.3	EMBL	CDS	3585677	3585949	.	-	0	ID=cds-CCP46024.1;Parent=gene-Rv3208A;Dbxref=EnsemblGenomes-Gn:Rv3208A,EnsemblGenomes-Tr:CCP46024,InterPro:IPR021456,UniProtKB/TrEMBL:Q6MWZ8,NCBI_GP:CCP46024.1;Name=CCP46024.1;Note=Rv3208A%2C len: 90 aa. TB9.4%2C conserved protein (see citations below)%2C equivalent to Q9CCH1|ML0814 hypothetical protein from Mycobacterium leprae (82 aa)%2C FASTA scores: opt: 411%2C E(): 1.8e-22%2C (81.0%25 identity in 79 aa overlap). Also similar%2C but shorter in N-terminus%2C to Q9FBI9|SCP8.32c putative ATP-binding protein from Streptomyces coelicolor (94 aa)%2C FASTA scores: opt: 246%2C E(): 8.1e-11%2C (53.4%25 identity in 73 aa overlap)%3B Q9DGP6 (alias Q9DGP4) glutamate decarboxylase 67 KDA isoform (fragment) from Alepocephalus bairdii (182 aa)%2C FASTA scores: opt: 100%2C E(): 2.6%2C (35.3%25 identity in 85 aa overlap). Corresponds to Statens Serum Institute antigen%2C CYP10 TB9.4. Has N-terminal sequence%2Cvevkigitdsprelv.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB9.4;locus_tag=Rv3208A;product=Conserved protein TB9.4;protein_id=CCP46024.1;transl_table=11
AL123456.3	EMBL	gene	3586274	3586834	.	+	.	ID=gene-Rv3209;Name=Rv3209;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3209
AL123456.3	EMBL	CDS	3586274	3586834	.	+	0	ID=cds-CCP46025.1;Parent=gene-Rv3209;Dbxref=EnsemblGenomes-Gn:Rv3209,EnsemblGenomes-Tr:CCP46025,GOA:O05857,InterPro:IPR008693,UniProtKB/TrEMBL:O05857,NCBI_GP:CCP46025.1;Name=CCP46025.1;Note=Rv3209%2C (MTCY07D11.17c)%2C len: 186 aa. Conserved hypothetical thr-%2C pro-rich protein%2C equivalent (but shorter 36 aa in N-terminus) to Q9CCH2|ML0813 putative membrane protein from Mycobacterium leprae (195 aa)%2C FASTA scores: opt: 508%2C E(): 1.4e-15%2C (58.4%25 identity in 185 aa overlap). Also some similarity with Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c probable conserved transmembrane transport protein from M. tuberculosis (299 aa)%2C FASTA scores: opt: 339%2C E(): 3.7e-08%2C (35.0%25 identity in 180 aa overlap)%3B and Q9CCE9|MMPS3|ML0877 putative membrane protein from Mycobacterium leprae (293 aa)%2C FASTA scores: opt: 272%2C E(): 2.8e-05%2C (36.4%25 identity in 173 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv3209;product=Conserved hypothetical threonine and proline rich protein;protein_id=CCP46025.1;transl_table=11
AL123456.3	EMBL	gene	3586844	3587539	.	-	.	ID=gene-Rv3210c;Name=Rv3210c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3210c
AL123456.3	EMBL	CDS	3586844	3587539	.	-	0	ID=cds-CCP46026.1;Parent=gene-Rv3210c;Dbxref=EnsemblGenomes-Gn:Rv3210c,EnsemblGenomes-Tr:CCP46026,InterPro:IPR009078,InterPro:IPR012347,UniProtKB/TrEMBL:O05856,NCBI_GP:CCP46026.1;Name=CCP46026.1;Note=Rv3210c%2C (MTCY07D11.16)%2C len: 231 aa. Conserved protein%2C similar (but N-terminus shorter) to Q9FBJ1|SCP8.30 conserved hypothetical protein from Streptomyces coelicolor (260 aa)%2C FASTA scores: opt: 599%2C E(): 1.1e-30%2C (42.5%25 identity in 233 aa overlap)%3B and some similarity to Q9RRV1|DR2384 phenylacetic acid degradation protein PAAC from Deinococcus radiodurans (263 aa)%2C FASTA scores: opt: 129%2C E(): 0.43%2C (27.9%25 identity in 172 aa overlap)%3B and Q9F621 FLGK protein from Rhizobium meliloti (Sinorhizobium meliloti) (472 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3210c;product=Conserved protein;protein_id=CCP46026.1;transl_table=11
AL123456.3	EMBL	gene	3587798	3589381	.	+	.	ID=gene-Rv3211;Name=rhlE;gbkey=Gene;gene=rhlE;gene_biotype=protein_coding;locus_tag=Rv3211
AL123456.3	EMBL	CDS	3587798	3589381	.	+	0	ID=cds-CCP46027.1;Parent=gene-Rv3211;Dbxref=EnsemblGenomes-Gn:Rv3211,EnsemblGenomes-Tr:CCP46027,GOA:O05855,InterPro:IPR000629,InterPro:IPR001650,InterPro:IPR011545,InterPro:IPR014001,InterPro:IPR014014,InterPro:IPR027417,UniProtKB/TrEMBL:O05855,NCBI_GP:CCP46027.1;Name=CCP46027.1;Note=Rv3211%2C (MTCY07D11.15c)%2C len: 527 aa. Probable rhlE%2CATP-dependent RNA helicase%2C equivalent (but shorter 22 aa) to Q9CCH3|RHLE|ML0811 putative ATP-dependent RNA helicase from Mycobacterium leprae (544 aa)%2C FASTA scores: opt: 2497%2C E(): 8.7e-131%2C (74.75%25 identity in 531 aa overlap). Also highly similar to other RNA helicases e.g. Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879 aa)%2CFASTA scores: opt: 1458%2C E(): 3.6e-73%2C (52.5%25 identity in 522 aa overlap)%3B Q9DF36 from Xenopus laevis (African clawed frog) (800 aa)%2C FASTA scores: opt: 792%2C E(): 2.3e-36%2C(37.15%25 identity in 385 aa overlap)%3B Q99Z38|dead|SPY1415 from Streptococcus pyogenes (759 aa)%2C FASTA scores: opt: 779%2C E(): 1.1e-35%2C (37.1%25 identity in 380 aa overlap)%3B P33906|dead|CSDA from Klebsiella pneumoniae (642 aa)%2C FASTA scores: opt: 768%2C E(): 4e-35%2C (43.4%25 identity in 387 aa overlap)%3B etc. Contains ATP/GTP-binding site motif A (PS00017) and dead-box subfamily ATP-dependent helicases signature (PS00039). Similar to dead/DEAH box helicase family and similar to helicase C-terminal domain.;gbkey=CDS;gene=rhlE;inference=protein motif:PROSITE:PS00039;locus_tag=Rv3211;product=Probable ATP-dependent RNA helicase RhlE;protein_id=CCP46027.1;transl_table=11
AL123456.3	EMBL	gene	3589394	3590617	.	+	.	ID=gene-Rv3212;Name=Rv3212;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3212
AL123456.3	EMBL	CDS	3589394	3590617	.	+	0	ID=cds-CCP46028.1;Parent=gene-Rv3212;Dbxref=EnsemblGenomes-Gn:Rv3212,EnsemblGenomes-Tr:CCP46028,GOA:O05854,InterPro:IPR011047,UniProtKB/TrEMBL:O05854,NCBI_GP:CCP46028.1;Name=CCP46028.1;Note=Rv3212%2C (MTCY07D11.14c)%2C len: 407 aa. Conserved ala-%2C val-rich protein%2C equivalent to Q9CCH4|ML0810 putative membrane protein from Mycobacterium leprae (407 aa)%2C FASTA scores: opt: 2158%2C E(): 5.3e-119%2C (79.85%25 identity in 407 aa overlap). Weak similarity to several eukaryotic transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 trans-acting transcriptional protein from Herpes simplex virus (type 1 / strain 17) (775 aa)%2C FASTA scores: opt: 115%2C E(): 2%2C (26.9%25 identity in 334 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3212;product=Conserved alanine valine rich protein;protein_id=CCP46028.1;transl_table=11
AL123456.3	EMBL	gene	3590692	3591492	.	-	.	ID=gene-Rv3213c;Name=Rv3213c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3213c
AL123456.3	EMBL	CDS	3590692	3591492	.	-	0	ID=cds-CCP46029.1;Parent=gene-Rv3213c;Dbxref=EnsemblGenomes-Gn:Rv3213c,EnsemblGenomes-Tr:CCP46029,GOA:O05853,InterPro:IPR002586,InterPro:IPR027417,UniProtKB/TrEMBL:O05853,NCBI_GP:CCP46029.1;Name=CCP46029.1;Note=Rv3213c%2C (MTCY07D11.13)%2C len: 266 aa. Possible soj/parA-related protein%2C very similar in particular to Soj/ParA proteins (and relatives) from Bacillus subtilis that inhibit the initiation of sporulation by preventing phosphorylation of Spo0A (see Quisel %26 Grossman 2000) e.g. Q9S228|SCI51.12c from Streptomyces coelicolor (340 aa)%2CFASTA scores: opt: 746%2C E(): 1.6e-40%2C (48.2%25 identity in 249 aa overlap)%3B Q9HT11|SOJ|PA5563 from Pseudomonas aeruginosa (262 aa)%2C FASTA scores: opt: 649%2C E(): 2.1e-34%2C(42.2%25 identity in 256 aa overlap)%3B Q9PB62|XF2282 from Xylella fastidiosa (264 aa)%2C FASTA scores: opt: 624%2C E(): 8.3e-33%2C (42.25%25 identity in 251 aa overlap)%3B Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus halodurans (253 aa)%2C FASTA scores: opt: 621%2C E(): 1.2e-32%2C (41.55%25 identity in 248 aa overlap)%3B P37522|SOJ_BACSU (253 aa)%2C FASTA scores: opt: 620%2C E(): 1.4e-32%2C (41.65%25 identity in 245%3B etc. Also similar to various mycobacterial proteins: U00021_10 from Mycobacterium leprae%2C MTCI125_29 from Mycobacterium tuberculosis%2C MLCB1351_6 from Mycobacterium leprae%2C MTV028_9c|Rv3918c|para probable chromosome partitioning protein from Mycobacterium tuberculosis%2CMSGDNAB_18 from Mycobacterium leprae. Seems to belong to the para family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3213c;product=Possible SOJ/para-related protein;protein_id=CCP46029.1;transl_table=11
AL123456.3	EMBL	repeat_region	3591493	3591569	.	-	.	ID=id-AL123456.3:3591493..3591569;Note=77 bp Mycobacterial Interspersed Repetitive Unit%2CClass I;gbkey=repeat_region
AL123456.3	EMBL	gene	3591646	3592257	.	+	.	ID=gene-Rv3214;Name=gpm2;gbkey=Gene;gene=gpm2;gene_biotype=protein_coding;gene_synonym=entD;locus_tag=Rv3214
AL123456.3	EMBL	CDS	3591646	3592257	.	+	0	ID=cds-CCP46030.1;Parent=gene-Rv3214;Dbxref=EnsemblGenomes-Gn:Rv3214,EnsemblGenomes-Tr:CCP46030,GOA:Q6MWZ7,InterPro:IPR013078,InterPro:IPR029033,UniProtKB/TrEMBL:Q6MWZ7,NCBI_GP:CCP46030.1;Name=CCP46030.1;Note=Rv3214%2C (MTCY07D11.12c)%2C len: 203 aa. Possible gpm2%2Cphosphoglycerate mutase%2C similar to many mutases especially phosphoglycerate mutases e.g. Q9F3H5|2SCC13.14c putative mutase from Streptomyces coelicolor (198 aa)%2C FASTA scores: opt: 487%2C E(): 4.4e-25%2C (42.25%25 identity in 194 aa overlap)%3B BAB49378|MLL2186 probable phosphoglycerate mutase from Rhizobium loti (Mesorhizobium loti) (193 aa)%2C FASTA scores: opt: 423%2C E(): 7e-21%2C (41.2%25 identity in 182 aa overlap)%3B Q9RKV8|SC9G1.08c putative phosphatase from Streptomyces coelicolor (199 aa)%2C FASTA scores: opt: 419%2CE(): 1.3e-20%2C (41.1%25 identity in 185 aa overlap)%3B Q9RDL0|SCC123.14c putative phosphoglycerate mutase from Streptomyces coelicolor (223 aa)%2C FASTA scores: opt: 240%2CE(): 8.8e-09%2C (36.9%25 identity in 168 aa overlap)%3B Q9X194|TM1374 phosphoglycerate mutase from Thermotoga maritima (201 aa)%2C FASTA scores: opt: 218%2C E(): 2.3e-07%2C(33.15%25 identity in 202 aa overlap)%3B etc. But N-terminus also similar to Q9CCH5|ENTC|ML0808 putative isochorismate synthase from Mycobacterium leprae (577 aa)%2C FASTA scores: opt: 346%2C E(): 2.1e-15%2C (55.05%25 identity in 109 aa overlap). N-terminus shows also some similarity with other M. tuberculosis proteins e.g. MTCY427.09c%3B MTCY20G9.15%3B MTCY428.28. Equivalent to AAK47652 from Mycobacterium tuberculosis strain CDC1551 (228 aa) but shorter 25 aa. Note that previously known as entD.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gpm2;locus_tag=Rv3214;product=Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM);protein_id=CCP46030.1;transl_table=11
AL123456.3	EMBL	gene	3592254	3593372	.	+	.	ID=gene-Rv3215;Name=entC;gbkey=Gene;gene=entC;gene_biotype=protein_coding;locus_tag=Rv3215
AL123456.3	EMBL	CDS	3592254	3593372	.	+	0	ID=cds-CCP46031.1;Parent=gene-Rv3215;Dbxref=EnsemblGenomes-Gn:Rv3215,EnsemblGenomes-Tr:CCP46031,GOA:P9WFW9,InterPro:IPR004561,InterPro:IPR005801,InterPro:IPR015890,NCBI_GP:CCP46031.1;Name=CCP46031.1;Note=Rv3215%2C (MTCY07D11.11c)%2C len: 372 aa. Probable entC%2Cisochorismate synthase%2C equivalent to Q9CCH5|ENTC|ML0808 putative isochorismate synthase from Mycobacterium leprae (577 aa)%2C FASTA scores: opt: 1817%2C E(): 5.5e-105%2C (73.5%25 identity in 366 aa overlap). Also similar to others e.g. Q9F639|MXCD protein involved in myxochelin-type iron chelator biosynthesis (see citation below) from Stigmatella aurantiaca (408 aa)%2C FASTA scores: opt: 893%2C E(): 6.2e-48%2C(41.6%25 identity in 382 aa overlap)%3B P45744|DHBC_BACSU isochorismate synthase from Bacillus subtilis (398 aa)%2CFASTA scores: opt: 883%2C E(): 2.5e-47%2C (40.45%25 identity in 393 aa overlap)%3B Q9KI93|CSBC isochorismate synthase (fragment) from Azotobacter vinelandii (361 aa)%2C FASTA scores: opt: 794%2C E(): 7.6e-42%2C (45.65%25 identity in 298 aa overlap)%3B and the two Escherichia coli proteins AAG54928|ENTC (alias BAB34055|ECS0632) isochorismate hydroxymutase 2 from Escherichia coli strain O157:H7 (391 aa)%2C FASTA scores: opt: 744%2C E(): 1e-38%2C (38.8%25 identity in 340 aa overlap)%3B P10377|ENTC|B0593 isochorismate synthase from Escherichia coli strain K12 (391 aa)%2C FASTA scores: opt: 744%2C E(): 1e-38%2C (38.8%25 identity in 340 aa overlap)%3B etc. Stronger similarity to Escherichia coli entC. Also similar to MTCY253.35.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=entC;locus_tag=Rv3215;product=Probable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis);protein_id=CCP46031.1;transl_table=11
AL123456.3	EMBL	pseudogene	3593369	3593437	.	+	.	ID=gene-Rv3216;Name=Rv3216;gbkey=Gene;gene_biotype=pseudogene;is_ordered=true;locus_tag=Rv3216;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	pseudogene	3593439	3593852	.	+	.	ID=gene-Rv3216;Name=Rv3216;gbkey=Gene;gene_biotype=pseudogene;is_ordered=true;locus_tag=Rv3216;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	3593369	3593437	.	+	0	ID=cds-Rv3216;Parent=gene-Rv3216;Dbxref=PSEUDO:CCP46032.1;Note=Rv3216%2C (MTCY07D11.10c)%2C len: 160 aa. Acetyltransferase (2.3.1.-)%2C contains GNAT domain (Gcn5-related N-acetyltransferase. See Vetting et al. 2005)%2C probably pseudogene as appears frameshifted due to 1bp insertion at position 3593438. Frameshift present in all sequenced tubercle bacilli. Start changed since first submission%2C extended by 50aa. Similar to many acetyltransferases e.g. Q9AB32|CC0402 acetyltransferase (GNAT family) from Caulobacter crescentus (159 aa)%2C FASTA scores: opt: 325%2C E(): 3.8e-17%2C (45.65%25 identity in 103 aa overlap)%3B P79081|ATS1 putative acetyltransferase ATS1 from Schizosaccharomyces pombe (Fission yeast) (168 aa)%2C FASTA scores: opt: 313%2C E(): 3.1e-16%2C (47.6%25 identity in 105 aa overlap).;gbkey=CDS;locus_tag=Rv3216;product=GCN5-related N-acetyltransferase%2C pseudogene;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	CDS	3593439	3593852	.	+	0	ID=cds-Rv3216;Parent=gene-Rv3216;Dbxref=PSEUDO:CCP46032.1;Note=Rv3216%2C (MTCY07D11.10c)%2C len: 160 aa. Acetyltransferase (2.3.1.-)%2C contains GNAT domain (Gcn5-related N-acetyltransferase. See Vetting et al. 2005)%2C probably pseudogene as appears frameshifted due to 1bp insertion at position 3593438. Frameshift present in all sequenced tubercle bacilli. Start changed since first submission%2C extended by 50aa. Similar to many acetyltransferases e.g. Q9AB32|CC0402 acetyltransferase (GNAT family) from Caulobacter crescentus (159 aa)%2C FASTA scores: opt: 325%2C E(): 3.8e-17%2C (45.65%25 identity in 103 aa overlap)%3B P79081|ATS1 putative acetyltransferase ATS1 from Schizosaccharomyces pombe (Fission yeast) (168 aa)%2C FASTA scores: opt: 313%2C E(): 3.1e-16%2C (47.6%25 identity in 105 aa overlap).;gbkey=CDS;locus_tag=Rv3216;product=GCN5-related N-acetyltransferase%2C pseudogene;pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	gene	3593804	3594235	.	-	.	ID=gene-Rv3217c;Name=Rv3217c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3217c
AL123456.3	EMBL	CDS	3593804	3594235	.	-	0	ID=cds-CCP46033.1;Parent=gene-Rv3217c;Dbxref=EnsemblGenomes-Gn:Rv3217c,EnsemblGenomes-Tr:CCP46033,UniProtKB/TrEMBL:O05849,NCBI_GP:CCP46033.1;Name=CCP46033.1;Note=Rv3217c%2C (MTCY07D11.09)%2C len: 143 aa. Probable conserved integral membrane protein%2C equivalent (highly similar but shorter 30 aa) to Q9CCH6|ML0806 putative membrane protein from Mycobacterium leprae (173 aa). Also similar to others e.g. Q9F3L9|2SC7G11.04 putative integral membrane protein from Streptomyces coelicolor (152 aa)%2CFASTA scores: opt: 177%2C E(): 0.00024%2C (33.8%25 identity in 136 aa overlap). And shows similarity to O34238|MVIN|VC0680 virulence factor MVIN homolog from Vibrio (525 aa)%2C FASTA scores: opt: 126%2C E(): 0.97%2C (30.9%25 identity in 68 aa overlap). First GTG taken. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;gbkey=CDS;locus_tag=Rv3217c;product=Probable conserved integral membrane protein;protein_id=CCP46033.1;transl_table=11
AL123456.3	EMBL	gene	3594468	3595433	.	+	.	ID=gene-Rv3218;Name=Rv3218;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3218
AL123456.3	EMBL	CDS	3594468	3595433	.	+	0	ID=cds-CCP46034.1;Parent=gene-Rv3218;Dbxref=EnsemblGenomes-Gn:Rv3218,EnsemblGenomes-Tr:CCP46034,GOA:O05848,InterPro:IPR001206,InterPro:IPR016064,InterPro:IPR017438,UniProtKB/TrEMBL:O05848,NCBI_GP:CCP46034.1;Name=CCP46034.1;Note=Rv3218%2C (MTCY07D11.08c)%2C len: 321 aa. Conserved protein%2C similar to several hypothetical bacterial proteins e.g. Q9F3M0|2SC7G11.03c from Streptomyces coelicolor (322 aa)%2C FASTA scores: opt: 694%2C E(): 4.2e-35%2C (39.95%25 identity in 328 aa overlap)%3B Q9A0J4|SPY0752 from Streptomyces pyogenes (340 aa)%2C FASTA scores: opt: 187%2C E(): 0.00033%2C(30.5%25 identity in 141 aa overlap)%3B O31502|YERQ from Bacillus subtilis (303 aa)%2C FASTA scores: opt: 184%2C E(): 0.00045%2C (34.15%25 identity in 126 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3218;product=Conserved protein;protein_id=CCP46034.1;transl_table=11
AL123456.3	EMBL	gene	3595713	3595967	.	+	.	ID=gene-Rv3219;Name=whiB1;gbkey=Gene;gene=whiB1;gene_biotype=protein_coding;gene_synonym=whmE;locus_tag=Rv3219
AL123456.3	EMBL	CDS	3595713	3595967	.	+	0	ID=cds-CCP46035.1;Parent=gene-Rv3219;Dbxref=EnsemblGenomes-Gn:Rv3219,EnsemblGenomes-Tr:CCP46035,GOA:P9WF43,InterPro:IPR003482,NCBI_GP:CCP46035.1;Name=CCP46035.1;Note=Rv3219%2C (MTCY07D11.07c)%2C len: 84 aa. WhiB1 (alternate gene name: whmE)%2C WhiB-like regulatory protein (see Hutter and Dick%2C 1999)%2C similar to WhiB paralogue of Streptomyces coelicolor. Equivalent to Q9CCH7|WHIB1|ML0804 putative transcriptional regulator from Mycobacterium leprae (84 aa)%2C FASTA scores: opt: 580%2C E(): 3.5e-35%2C(95.25%25 identity in 84 aa overlap). Highly similar to several e.g. Q9X952|WBLE developmental regulatory protein WhiB-paralog from Streptomyces coelicolor (85 aa)%2C FASTA scores: opt: 477%2C E(): 9.2e-28%2C (75.3%25 identity in 81 aa overlap)%3B Q9AD55|SCP1.95 putative regulatory protein from Streptomyces coelicolor (102 aa)%2C FASTA scores: opt: 383%2CE(): 6.1e-21%2C (60.75%25 identity in 79 aa overlap)%3B Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83 aa)%2CFASTA scores: opt: 346%2C E(): 2.5e-18%2C (54.75%25 identity in 84 aa overlap)%3B etc.;gbkey=CDS;gene=whiB1;locus_tag=Rv3219;product=Transcriptional regulatory protein WhiB-like WhiB1. Contains [4FE-4S]2+ cluster.;protein_id=CCP46035.1;transl_table=11
AL123456.3	EMBL	gene	3596029	3597534	.	-	.	ID=gene-Rv3220c;Name=Rv3220c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3220c
AL123456.3	EMBL	CDS	3596029	3597534	.	-	0	ID=cds-CCP46036.1;Parent=gene-Rv3220c;Dbxref=EnsemblGenomes-Gn:Rv3220c,EnsemblGenomes-Tr:CCP46036,GOA:P9WGL5,InterPro:IPR000014,InterPro:IPR003594,InterPro:IPR005467,InterPro:IPR011495,InterPro:IPR022066,PDB:2YKF,PDB:2YKH,NCBI_GP:CCP46036.1;Name=CCP46036.1;Note=Rv3220c%2C (MTCY07D11.06)%2C len: 501 aa. Probable sensor (probably histidine kinase)%2C equivalent to Q9CCH8|ML0803 putative two-component system sensor kinase from Mycobacterium leprae (500 aa). Similar to others e.g. Q9F3M1|2SC7G11.01 putative histidine kinase (fragment) from Streptomyces coelicolor (372 aa)%2C FASTA scores: opt: 1038%2CE(): 7.4e-56%2C (48.95%25 identity in 380 aa overlap)%3B Q9A3K5|CC3198 sensor histidine kinase from Caulobacter crescentus (327 aa)%2C FASTA scores: opt: 311%2C E(): 1.2e-11%2C(33.35%25 identity in 201 aa overlap) (similarity only in C-terminal part for this one)%3B Q9A2T2|CC3474 putative sensor histidine kinase from Caulobacter crescentus (547 aa)%3B etc. C-terminal half shows similarity to many sensor proteins%2C that respond to various stimuli from Methanobacterium thermoautotrophicum e.g. O26568|MTH468 sensory transduction histidine kinase (554 aa)%2C FASTA scores: opt: 425%2C E(): 2.1e-18%2C (34.0%25 identity in 244 aa overlap)%3B O26546|MTH446 sensory transduction regulatory protein (583 aa)%2C FASTA scores: opt: 380%2C E(): 1.2e-15%2C(37.15%25 identity in 202 aa overlap)%3B O26913|MTH823 sensory transduction regulatory protein (677 aa)%2C FASTA scores: opt: 375%2C E(): 2.7e-15%2C (35.4%25 identity in 195 aa overlap)%3B etc. Seems similar to other prokaryotic sensory transduction histidine kinases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3220c;product=Probable two component sensor kinase;protein_id=CCP46036.1;transl_table=11
AL123456.3	EMBL	gene	3597551	3597766	.	-	.	ID=gene-Rv3221c;Name=TB7.3;gbkey=Gene;gene=TB7.3;gene_biotype=protein_coding;locus_tag=Rv3221c
AL123456.3	EMBL	CDS	3597551	3597766	.	-	0	ID=cds-CCP46037.1;Parent=gene-Rv3221c;Dbxref=EnsemblGenomes-Gn:Rv3221c,EnsemblGenomes-Tr:CCP46037,InterPro:IPR000089,InterPro:IPR011053,NCBI_GP:CCP46037.1;Name=CCP46037.1;Note=Rv3221c%2C (MTCY07D11.05)%2C len: 71 aa. TB7.3%2CBiotinylated protein (see citations below)%2C equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3 homolog from Mycobacterium leprae (70 aa)%2C FASTA scores: opt: 367%2CE(): 4e-18%2C (90.0%25 identity in 70 aa overlap)%3B Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from Mycobacterium smegmatis (70 aa)%2C FASTA scores: opt: 341%2CE(): 2.1e-16%2C (84.05%25 identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G biotin carboxylase from Halobacterium sp. strain NRC-1 (610 aa)%2C FASTA scores: opt: 212%2C E(): 4e-07%2C (50.0%25 identity in 68 aa overlap)%3B Q58628|PYCB_METJA|MJ1231 pyruvate carboxylase subunit B from Methanococcus jannaschii (567 aa)%2C FASTA scores: opt: 192%2C E(): 7.8e-06%2C (44.8%25 identity in 58 aa overlap)%3B Q9ZAA7|GCDC glutaconyl-CoA decarboxylase gamma subunit from Acidaminococcus fermentans (145 aa)%2C FASTA scores: opt: 184%2C E(): 8.9e-06%2C (39.4%25 identity in 66 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=TB7.3;locus_tag=Rv3221c;product=Biotinylated protein TB7.3;protein_id=CCP46037.1;transl_table=11
AL123456.3	EMBL	gene	3598051	3598356	.	-	.	ID=gene-Rv3221A;Name=rshA;gbkey=Gene;gene=rshA;gene_biotype=protein_coding;locus_tag=Rv3221A
AL123456.3	EMBL	CDS	3598051	3598356	.	-	0	ID=cds-CCP46038.1;Parent=gene-Rv3221A;Dbxref=EnsemblGenomes-Gn:Rv3221A,EnsemblGenomes-Tr:CCP46038,GOA:P9WJ69,InterPro:IPR014295,InterPro:IPR024020,InterPro:IPR027383,NCBI_GP:CCP46038.1;Name=CCP46038.1;Note=Rv3221A%2C len: 101 aa. RshA%2C anti-sigma factor%2Csimilar to Q9XCD7|AAD41811.1 unknown protein from Mycobacterium smegmatis%2C linked to sigma factor sigH (see Fernandes et al.%2C 1999) (101 aa)%2C FASTA scores: opt: 422%2CE(): 3.4e-22%2C (64.9%25 identity in 94 aa overlap)%3B and to Q9RL96|RsrA anti-sigma factor from Streptomyces coelicolor (see Kang et al.%2C 1999) (105 aa)%2C FASTA scores: opt: 163%2CE(): 0.00016%2C (32.05%25 identity in 78 aa overlap).;gbkey=CDS;gene=rshA;locus_tag=Rv3221A;product=Anti-sigma factor RshA;protein_id=CCP46038.1;transl_table=11
AL123456.3	EMBL	gene	3598353	3598904	.	-	.	ID=gene-Rv3222c;Name=Rv3222c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3222c
AL123456.3	EMBL	CDS	3598353	3598904	.	-	0	ID=cds-CCP46039.1;Parent=gene-Rv3222c;Dbxref=EnsemblGenomes-Gn:Rv3222c,EnsemblGenomes-Tr:CCP46039,UniProtKB/TrEMBL:O05844,NCBI_GP:CCP46039.1;Name=CCP46039.1;Note=Rv3222c%2C (MTCY07D11.04)%2C len: 183 aa. Hypothetical protein%2C with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa)%2C FASTA scores: opt: 131%2C E(): 0.77%2C (33.35%25 identity in 126 aa overlap)%3B Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa)%2C FASTA scores: opt: 133%2C E(): 1.6%2C(36.25%25 identity in 149 aa overlap)%3B etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa)%2C FASTA scores: opt: 141%2C E(): 0.5%2C (31.2%25 identity in 170 aa overlap)%3B AAK45760|MT1497.1 PE_PGRS family protein from strain CDC1551 (1408 aa)%2C FASTA scores: opt: 137%2C E(): 2%2C(31.75%25 identity in 148 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3222c;product=Conserved hypothetical protein;protein_id=CCP46039.1;transl_table=11
AL123456.3	EMBL	gene	3598901	3599551	.	-	.	ID=gene-Rv3223c;Name=sigH;gbkey=Gene;gene=sigH;gene_biotype=protein_coding;gene_synonym=rpoE;locus_tag=Rv3223c
AL123456.3	EMBL	CDS	3598901	3599551	.	-	0	ID=cds-CCP46040.1;Parent=gene-Rv3223c;Dbxref=EnsemblGenomes-Gn:Rv3223c,EnsemblGenomes-Tr:CCP46040,GOA:P9WGH9,InterPro:IPR000838,InterPro:IPR007627,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,InterPro:IPR014293,NCBI_GP:CCP46040.1;Name=CCP46040.1;Note=Rv3223c%2C (MTCY07D11.03)%2C len: 216 aa. SigH (alternate gene name: rpoE)%2C alternative RNA polymerase sigma factor (see citations below)%2C similar to many e.g. Q9XCD8|sigh from Mycobacterium smegmatis (215 aa)%2C FASTA scores: opt: 1187%2C E(): 8.1e-69%2C (87.75%25 identity in 212 aa overlap)%3B O87834|SIGR from Streptomyces coelicolor (227 aa)%2C FASTA scores: opt: 913%2C E(): 2.6e-51%2C (68.8%25 identity in 202 aa overlap)%3B O68520|RPOE1 from Myxococcus xanthus (213 aa)%2C FASTA scores: opt: 452%2C E(): 6.7e-22%2C (42.8%25 identity in 187 aa overlap)%3B Q06198|RPSH_PSEAE|ALGU|ALGT|PA0762 from Pseudomonas aeruginosa (193 aa)%2C FASTA scores: opt: 301%2C E(): 2.7e-12%2C(29.9%25 identity in 194 aa overlap)%3B etc. Equivalent to AAK47662 RNA polymerase sigma-70 factor from Mycobacterium tuberculosis strain CDC1551 (284 aa)%2C but shorter 68 aa. Has sigma-70 factors ECF subfamily signature (PS01063). So belongs to the sigma-70 factor family%2C ECF subfamily. Start chosen on basis of similarity%2C other potential starts upstream.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigH;inference=protein motif:PROSITE:PS01063;locus_tag=Rv3223c;product=Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE);protein_id=CCP46040.1;transl_table=11
AL123456.3	EMBL	gene	3599851	3600699	.	+	.	ID=gene-Rv3224;Name=Rv3224;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3224
AL123456.3	EMBL	CDS	3599851	3600699	.	+	0	ID=cds-CCP46041.1;Parent=gene-Rv3224;Dbxref=EnsemblGenomes-Gn:Rv3224,EnsemblGenomes-Tr:CCP46041,GOA:O05842,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:O05842,NCBI_GP:CCP46041.1;Name=CCP46041.1;Note=Rv3224%2C (MTCY07D11.02c)%2C len: 282 aa. Probable iron-regulated oxidoreductase%2C possible short-chain dehydrogenase/reductase%2C highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa)%2C FASTA scores: opt: 1053%2C E(): 6.4e-59%2C(57.95%25 identity in 276 aa overlap)%3B Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa)%2C FASTA scores: opt: 1051%2C E(): 8.5e-59%2C(55.9%25 identity in 281 aa overlap)%3B and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosophila melanogaster (Fruit fly) (412 aa)%2C FASTA scores: opt: 966%2CE(): 2.5e-53%2C (52.15%25 identity in 278 aa overlap). Similar to various proteins (principaly oxidoreductases) e.g. Q18639|C45B11.3 hypothetical protein (similar to the SDR family) from Caenorhabditis elegans (293 aa)%2C FASTA scores: opt: 921%2C E(): 1.2e-50%2C (51.3%25 identity in 271 aa overlap)%3B Q9HZV5|PA2892 probable short-chain dehydrogenase from Pseudomonas aeruginosa (274 aa)%2C FASTA scores: opt: 847%2CE(): 5.1e-46%2C (49.25%25 identity in 274 aa overlap)%3B Q9I6V0|PA0182 probable short-chain dehydrogenase (similar to the SDR family) from Pseudomonas aeruginosa (250 aa)%2CFASTA scores: opt: 333%2C E(): 8.3e-14%2C (29.8%25 identity in 245 aa overlap)%3B Q9HY98|PA3511 probable short-chain dehydrogenase from Pseudomonas aeruginosa (253 aa)%2C FASTA scores: opt: 330%2C E(): 1.3e-13%2C (31.2%25 identity in 250 aa overlap)%3B etc. Related proteins in Mycobacterium tuberculosis include MTCY02B10.14%2C MTCY369.14%2C and MTCY09F9.36. Has ATP/GTP-binding site motif A%2C (PS00017) near C-terminus. May be belong to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3224;product=Possible iron-regulated short-chain dehydrogenase/reductase;protein_id=CCP46041.1;transl_table=11
AL123456.3	EMBL	gene	3600635	3600823	.	+	.	ID=gene-Rv3224A;Name=Rv3224A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3224A
AL123456.3	EMBL	CDS	3600635	3600823	.	+	0	ID=cds-CCP46042.1;Parent=gene-Rv3224A;Dbxref=EnsemblGenomes-Gn:Rv3224A,EnsemblGenomes-Tr:CCP46042,UniProtKB/TrEMBL:Q6MWZ5,NCBI_GP:CCP46042.1;Name=CCP46042.1;Note=Rv3224A%2C len: 62 aa. Conserved hypothetical protein (possibly gene fragment)%2C overlaps Rv3224. Similar to N-terminus of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa)%2C FASTA scores: opt: 104%2C E(): 0.78%2C (59.37%25 identity in 32 aa overlap). Note that upstream ORF Rv3224B is similar to C-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;locus_tag=Rv3224A;product=Conserved hypothetical protein;protein_id=CCP46042.1;transl_table=11
AL123456.3	EMBL	gene	3600801	3601019	.	+	.	ID=gene-Rv3224B;Name=Rv3224B;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3224B
AL123456.3	EMBL	CDS	3600801	3601019	.	+	0	ID=cds-CCP46043.1;Parent=gene-Rv3224B;Dbxref=EnsemblGenomes-Gn:Rv3224B,EnsemblGenomes-Tr:CCP46043,GOA:Q6MWZ4,InterPro:IPR007214,UniProtKB/TrEMBL:Q6MWZ4,NCBI_GP:CCP46043.1;Name=CCP46043.1;Note=Rv3224B%2C len: 72 aa. Conserved hypothetical protein (possibly gene fragment)%2C similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa)%2C FASTA scores: opt: 229%2C E(): 2e-09%2C (60.00%25 identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv3224B;product=Conserved hypothetical protein;protein_id=CCP46043.1;transl_table=11
AL123456.3	EMBL	gene	3601016	3602440	.	-	.	ID=gene-Rv3225c;Name=Rv3225c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3225c
AL123456.3	EMBL	CDS	3601016	3602440	.	-	0	ID=cds-CCP46044.1;Parent=gene-Rv3225c;Dbxref=EnsemblGenomes-Gn:Rv3225c,EnsemblGenomes-Tr:CCP46044,GOA:O05841,InterPro:IPR000182,InterPro:IPR002575,InterPro:IPR011009,InterPro:IPR016181,InterPro:IPR024165,UniProtKB/TrEMBL:O05841,NCBI_GP:CCP46044.1;Name=CCP46044.1;Note=Rv3225c%2C (MTCY07D11.01)%2C len: 474 aa. Conserved hypothetical protein has GNAT (Gcn5-related N-acetyltransferase) domain in N-terminal part (see Vetting et al. 2005) and phosphotransferase domain in C-terminal part. C-terminal part shows similarity to various bacterial phosphotransferases e.g. BAB49093|MLL1809 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (298 aa)%2CFASTA scores: opt: 557%2C E(): 2.8e-26%2C (34.55%25 identity in 295 aa overlap)%3B P14509|KKA8_ECOLI|APHA aminoglycoside 3'-phosphotransferase from Escherichia coli (271 aa)%2C FASTA scores: opt: 194%2C E(): 0.00018%2C (27.75%25 identity in 227 aa overlap)%3B Q53826|CPH capreomycin phosphotransferase from Streptomyces capreolus (281 aa)%2C FASTA scores: opt: 178%2CE(): 0.0017%2C (30.5%25 identity in 269 aa overlap).;gbkey=CDS;locus_tag=Rv3225c;product=GCN5-related N-acetyltransferase%2C phosphorylase;protein_id=CCP46044.1;transl_table=11
AL123456.3	EMBL	gene	3602564	3603322	.	-	.	ID=gene-Rv3226c;Name=Rv3226c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3226c
AL123456.3	EMBL	CDS	3602564	3603322	.	-	0	ID=cds-CCP46045.1;Parent=gene-Rv3226c;Dbxref=EnsemblGenomes-Gn:Rv3226c,EnsemblGenomes-Tr:CCP46045,InterPro:IPR003738,UniProtKB/TrEMBL:O05872,NCBI_GP:CCP46045.1;Name=CCP46045.1;Note=Rv3226c%2C (MTCY20B11.01c)%2C len: 252 aa. Conserved hypothetical protein%2C similar to various hypothetical bacterial proteins e.g. Q9CCI2|ML0793 putative bacteriophage protein from Mycobacterium leprae (252 aa)%2CFASTA scores: opt: 1183%2C E(): 3.8e-68%2C (70.65%25 identity in 252 aa overlap)%3B BAB54183|MLR7795 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (369 aa)%2C FASTA scores: opt: 417%2C E(): 2.9e-19%2C (33.75%25 identity in 252 aa overlap)%3B O64131 YOQW protein from Bacteriophage SPBc2 (224 aa)%2C FASTA scores: opt: 413%2C E(): 3.4e-19%2C (38.5%25 identity in 244 aa overlap)%3B O31916 YOQW protein from Bacillus subtilis (224 aa)%2C FASTA scores: opt: 413%2C E(): 3.4e-19%2C(38.5%25 identity in 244 aa overlap)%3B O34906 YOAM protein from Bacillus subtilis (227 aa)%2C FASTA scores: opt: 401%2CE(): 2e-18%2C (37.7%25 identity in 244 aa overlap)%3B Q9K4A5|SC7E4.11 hypothetical 30.8 KDA protein from Streptomyces coelicolor (271 aa)%2C FASTA scores: opt: 383%2CE(): 3.3e-17%2C (39.6%25 identity in 283 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3226c;product=Conserved hypothetical protein;protein_id=CCP46045.1;transl_table=11
AL123456.3	EMBL	gene	3603377	3604729	.	+	.	ID=gene-Rv3227;Name=aroA;gbkey=Gene;gene=aroA;gene_biotype=protein_coding;locus_tag=Rv3227
AL123456.3	EMBL	CDS	3603377	3604729	.	+	0	ID=cds-CCP46046.1;Parent=gene-Rv3227;Dbxref=EnsemblGenomes-Gn:Rv3227,EnsemblGenomes-Tr:CCP46046,GOA:P9WPY5,InterPro:IPR001986,InterPro:IPR006264,InterPro:IPR013792,InterPro:IPR023193,PDB:2BJB,PDB:2O0B,PDB:2O0D,PDB:2O0E,PDB:2O0X,PDB:2O0Z,PDB:2O15,NCBI_GP:CCP46046.1;Name=CCP46046.1;Note=Rv3227%2C (MTCY20B11.02)%2C len: 450 aa. AroA%2C3-phosphoshikimate 1-carboxyvinyl transferase (see citation below)%2C equivalent (but C-terminus longer) to Q9CCI3|AROA|ML0792 putative 3-phosphoshikimate 1-carboxyvinyl transferase from Mycobacterium leprae (430 aa)%2C FASTA scores: opt: 1466%2C E(): 1.4e-78%2C (55.05%25 identity in 427 aa overlap). Contains PS00885 EPSP synthase signature 2. Belongs to the EPSP synthase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aroA;inference=protein motif:PROSITE:PS00885;locus_tag=Rv3227;product=3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS);protein_id=CCP46046.1;transl_table=11
AL123456.3	EMBL	gene	3604726	3605718	.	+	.	ID=gene-Rv3228;Name=Rv3228;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3228
AL123456.3	EMBL	CDS	3604726	3605718	.	+	0	ID=cds-CCP46047.1;Parent=gene-Rv3228;Dbxref=EnsemblGenomes-Gn:Rv3228,EnsemblGenomes-Tr:CCP46047,GOA:O05873,InterPro:IPR004881,InterPro:IPR010914,InterPro:IPR027417,UniProtKB/TrEMBL:O05873,NCBI_GP:CCP46047.1;Name=CCP46047.1;Note=Rv3228%2C (MTCY20B11.03)%2C len: 330 aa. Conserved hypothetical protein%2C equivalent to Q9CCI4|ML0791 hypothetical protein from Mycobacterium leprae (327 aa)%2CFASTA scores: opt: 1828%2C E(): 1e-98%2C (84.0%25 identity in 331 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces coelicolor (337 aa)%2C FASTA scores: opt: 1051%2C E(): 1e-53%2C (52.65%25 identity in 338 aa overlap)%3B Q9HUL3|PA4952 from Pseudomonas aeruginosa (339 aa)%2C FASTA scores: opt: 392 %2CE(): 1.4e-15%2C(34.85%25 identity in 281 aa overlap)%3B Q9PFV1|XF0556 from Xylella fastidiosa (341 aa)%2C FASTA scores: opt: 367%2C E(): 4e-14%2C (36.85%25 identity in 247 aa overlap)%3B P45339|YJEQ_HAEIN|HI1714 from Haemophilus influenzae (346 aa)%2C FASTA scores: opt: 355%2C E(): 2e-13%2C (31.65%25 identity in 281 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3228;product=Conserved hypothetical protein;protein_id=CCP46047.1;transl_table=11
AL123456.3	EMBL	gene	3605751	3607034	.	-	.	ID=gene-Rv3229c;Name=desA3;gbkey=Gene;gene=desA3;gene_biotype=protein_coding;locus_tag=Rv3229c
AL123456.3	EMBL	CDS	3605751	3607034	.	-	0	ID=cds-CCP46048.1;Parent=gene-Rv3229c;Dbxref=EnsemblGenomes-Gn:Rv3229c,EnsemblGenomes-Tr:CCP46048,GOA:P9WNZ3,InterPro:IPR005804,NCBI_GP:CCP46048.1;Name=CCP46048.1;Note=Rv3229c%2C (MTCY20B11.04c)%2C len: 427 aa. DesA3%2Clinoleoyl-CoA desaturase%2C showing similarity with desaturases and other proteins e.g. Q08871|DES6|SLL0262 linoleoyl-CoA desaturase from Synechocystis sp. strain PCC 6803 (359 aa)%2C FASTA scores: opt: 319%2C E(): 4e-13%2C (25.1%25 identity in 295 aa overlap)%3B Q54795|DESD delta 6 desaturase from Spirulina platensis (368 aa)%2C FASTA scores: opt: 268%2CE(): 7.7e-10%2C (25.0%25 identity in 300 aa overlap)%3B Q9ZTU8|S276 protein with similarity to cytochrome B5 domain from Triticum aestivum (Wheat) (469 aa)%2C FASTA scores: opt: 240%2C E(): 5.9e-08%2C (27.05%25 identity in 266 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=desA3;locus_tag=Rv3229c;product=Possible linoleoyl-CoA desaturase (delta(6)-desaturase);protein_id=CCP46048.1;transl_table=11
AL123456.3	EMBL	gene	3607112	3608254	.	-	.	ID=gene-Rv3230c;Name=Rv3230c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3230c
AL123456.3	EMBL	CDS	3607112	3608254	.	-	0	ID=cds-CCP46049.1;Parent=gene-Rv3230c;Dbxref=EnsemblGenomes-Gn:Rv3230c,EnsemblGenomes-Tr:CCP46049,GOA:P9WNE9,InterPro:IPR001041,InterPro:IPR001221,InterPro:IPR001433,InterPro:IPR001709,InterPro:IPR008333,InterPro:IPR012675,InterPro:IPR017927,InterPro:IPR017938,NCBI_GP:CCP46049.1;Name=CCP46049.1;Note=Rv3230c%2C (MTCY20B11.05c)%2C len: 380 aa. Putative oxidoreductase%2C with some similarity to various proteins%2Cespecially reductases e.g. Q9HUS4|PA4889 probable oxidoreductase from Pseudomonas aeruginosa (366 aa)%2C FASTA scores: opt: 516%2C E(): 1.8e-24%2C (33.8%25 identity in 367 aa overlap)%3B P95533|TDNB electron transfer protein from Pseudomonas putida (337 aa)%2C FASTA scores: opt: 380%2C E(): 4e-16%2C (30.7%25 identity in 277 aa overlap)%3B BAB34381|ECS0958 NADH oxidoreductase for the HCP from Escherichia coli strain O157:H7 (322 aa)%2C FASTA scores: opt: 369%2C E(): 1.8e-15%2C (28.65%25 identity in 328 aa overlap)%3B Q44253|ATDA5 aniline dioxygenase reductase component from Acinetobacter sp. (336 aa)%2C FASTA scores: opt: 305%2C E(): 1.6e-11%2C (27.4%25 identity in 303 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3230c;product=Hypothetical oxidoreductase;protein_id=CCP46049.1;transl_table=11
AL123456.3	EMBL	gene	3608364	3608873	.	-	.	ID=gene-Rv3231c;Name=Rv3231c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3231c
AL123456.3	EMBL	CDS	3608364	3608873	.	-	0	ID=cds-CCP46050.1;Parent=gene-Rv3231c;Dbxref=EnsemblGenomes-Gn:Rv3231c,EnsemblGenomes-Tr:CCP46050,UniProtKB/TrEMBL:O05876,NCBI_GP:CCP46050.1;Name=CCP46050.1;Note=Rv3231c%2C (MTCY20B11.06c)%2C len: 169 aa. Conserved protein%2C similar to Q9KYX9|SCE33.03c hypothetical 17.4 KDA protein from Streptomyces coelicolor (167 aa)%2C FASTA scores: opt: 415%2C E(): 6.6e-19%2C (49.1%25 identity in 171 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3231c;product=Conserved protein;protein_id=CCP46050.1;transl_table=11
AL123456.3	EMBL	gene	3608870	3609757	.	-	.	ID=gene-Rv3232c;Name=ppk2;gbkey=Gene;gene=ppk2;gene_biotype=protein_coding;locus_tag=Rv3232c
AL123456.3	EMBL	CDS	3608870	3609757	.	-	0	ID=cds-CCP46051.1;Parent=gene-Rv3232c;Dbxref=EnsemblGenomes-Gn:Rv3232c,EnsemblGenomes-Tr:CCP46051,GOA:O05877,InterPro:IPR016898,InterPro:IPR022486,InterPro:IPR022488,InterPro:IPR027417,UniProtKB/TrEMBL:O05877,NCBI_GP:CCP46051.1;Name=CCP46051.1;Note=Rv3232c%2C (MTCY20B11.07c)%2C len: 295 aa (start uncertain). Ppk2%2C polyphosphate kinase 2%2C highly similar to Q9I154|PA2428 hypothetical protein from Pseudomonas aeruginosa (304 aa)%2C FASTA scores: opt: 1057%2C E(): 6.8e-62%2C(60.7%25 identity in 252 aa overlap)%3B Q9I6Z1|PA0141 hypothetical protein from Pseudomonas aeruginosa (298 aa)%2CFASTA scores: opt: 990%2C E(): 1.6e-57%2C (54.6%25 identity in 249 aa overlap)%3B and other hypothetical bacterial proteins. Note that previously known as pvdS. Ppk2|Rv3232c and NdkA|Rv2445c interact (See Sureka et al.%2C 2009).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppk2;locus_tag=Rv3232c;product=Polyphosphate kinase Ppk2 (polyphosphoric acid kinase);protein_id=CCP46051.1;transl_table=11
AL123456.3	EMBL	gene	3609781	3610371	.	-	.	ID=gene-Rv3233c;Name=Rv3233c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3233c
AL123456.3	EMBL	CDS	3609781	3610371	.	-	0	ID=cds-CCP46052.1;Parent=gene-Rv3233c;Dbxref=EnsemblGenomes-Gn:Rv3233c,EnsemblGenomes-Tr:CCP46052,GOA:O05878,UniProtKB/TrEMBL:O05878,NCBI_GP:CCP46052.1;Name=CCP46052.1;Note=Rv3233c%2C (MTCY20B11.08c)%2C len: 196 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C similar to C-terminus of Q9RIU8|SCM11.13c hypothetical 47.1 KDA protein from Streptomyces coelicolor (446 aa)%2C FASTA scores: opt: 308%2C E(): 1.2e-12%2C (32.0%25 identity in 200 aa overlap)%3B and several hypothetical M. tuberculosis proteins e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa)%2CFASTA scores: opt: 248%2C E(): 9.8e-09%2C (27.5%25 identity in 200 aa overlap)%3B MTCY28_26%3B MTCY493_29%3B MTCY31_25%3B MTCY31_25.;gbkey=CDS;locus_tag=Rv3233c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP46052.1;transl_table=11
AL123456.3	EMBL	gene	3610374	3611189	.	-	.	ID=gene-Rv3234c;Name=tgs3;gbkey=Gene;gene=tgs3;gene_biotype=protein_coding;locus_tag=Rv3234c
AL123456.3	EMBL	CDS	3610374	3611189	.	-	0	ID=cds-CCP46053.1;Parent=gene-Rv3234c;Dbxref=EnsemblGenomes-Gn:Rv3234c,EnsemblGenomes-Tr:CCP46053,GOA:P9WKC5,InterPro:IPR004255,NCBI_GP:CCP46053.1;Name=CCP46053.1;Note=Rv3234c%2C (MTCY20B11.09c)%2C len: 271 aa. Putative tgs3%2C triacylglycerol synthase (See Daniel et al.%2C 2004)%2Csimilar to C-terminus of Mycobacterium tuberculosis hypothetical proteins e.g. P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa)%2C FASTA scores: opt: 498%2C E(): 5.2e-24%2C (36.8%25 identity in 261 aa overlap)%3B MTCY03A2.28%3B MTCY31.23%3B MTCY493_29%3B MTCY28_26%3B MTV013_8%3B MTY13E12_33%3B etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from Mycobacterium leprae (491 aa)%2C FASTA scores: opt: 309%2C E(): 4.3e-12%2C (33.35%25 identity in 189 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tgs3;locus_tag=Rv3234c;product=Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3;protein_id=CCP46053.1;transl_table=11
AL123456.3	EMBL	gene	3611300	3611941	.	+	.	ID=gene-Rv3235;Name=Rv3235;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3235
AL123456.3	EMBL	CDS	3611300	3611941	.	+	0	ID=cds-CCP46054.1;Parent=gene-Rv3235;Dbxref=EnsemblGenomes-Gn:Rv3235,EnsemblGenomes-Tr:CCP46054,GOA:O05880,UniProtKB/TrEMBL:O05880,NCBI_GP:CCP46054.1;Name=CCP46054.1;Note=Rv3235%2C (MTCY20B11.10)%2C len: 213 aa. Hypothetical unknown ala-%2C arg-%2C pro-rich protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3235;product=Hypothetical alanine arginine proline rich protein;protein_id=CCP46054.1;transl_table=11
AL123456.3	EMBL	gene	3611959	3613116	.	-	.	ID=gene-Rv3236c;Name=Rv3236c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3236c
AL123456.3	EMBL	CDS	3611959	3613116	.	-	0	ID=cds-CCP46055.1;Parent=gene-Rv3236c;Dbxref=EnsemblGenomes-Gn:Rv3236c,EnsemblGenomes-Tr:CCP46055,GOA:L7N665,InterPro:IPR006153,UniProtKB/TrEMBL:L7N665,NCBI_GP:CCP46055.1;Name=CCP46055.1;Note=Rv3236c%2C (MTCY20B11.11c)%2C len: 385 aa. Probable conserved integral membrane transport protein%2C possibly cation (Na/H) transporter%2C equivalent to Q9CCI5|ML0782 putative transmembrane transport protein from Mycobacterium leprae (385 aa)%2C FASTA scores: opt: 1975%2C E(): 2.4e-108%2C(81.55%25 identity in 385 aa overlap). Highly similar to others e.g. O69958|SC4H2.03c putative transmembrane transport protein from Streptomyces coelicolor (411 aa)%2CFASTA scores: opt: 1226%2C E(): 1.6e-64%2C (53.5%25 identity in 372 aa overlap)%3B Q9XAKO|SC66T3.13c putative transmembrane transport protein from Streptomyces coelicolor (403 aa)%2CFASTA scores: opt: 1198%2C E(): 6.8e-63%2C (53.25%25 identity in 370 aa overlap)%3B Q9RV80|DR1149 putative Na+/H+ antiporter from Deinococcus radiodurans (383 aa)%2C FASTA scores: opt: 1069%2C E(): 2.3e-55%2C (47.35%25 identity in 376 aa overlap)%3B Q9L191|SC10G8.11 putative transmembrane transport protein from Streptomyces coelicolor (446 aa)%2C FASTA scores: opt: 695%2C E(): 1.9e-33%2C (38.05%25 identity in 384 aa overlap)%3B Q9RRW8|DR2367 putative glutathione-regulated potassium-efflux system protein KEFB from Deinococcus radiodurans (575 aa)%2C FASTA scores: opt: 414%2C E(): 6.2e-17%2C(30.25%25 identity in 380 aa overlap)%3B etc. Seems to belong to the CPA2 family. Note that previously known as kefB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3236c;product=Probable conserved integral membrane transport protein;protein_id=CCP46055.1;transl_table=11
AL123456.3	EMBL	gene	3613121	3613603	.	-	.	ID=gene-Rv3237c;Name=Rv3237c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3237c
AL123456.3	EMBL	CDS	3613121	3613603	.	-	0	ID=cds-CCP46056.1;Parent=gene-Rv3237c;Dbxref=EnsemblGenomes-Gn:Rv3237c,EnsemblGenomes-Tr:CCP46056,GOA:O05882,InterPro:IPR006037,InterPro:IPR026278,UniProtKB/TrEMBL:O05882,NCBI_GP:CCP46056.1;Name=CCP46056.1;Note=Rv3237c%2C (MTCY20B11.12c)%2C len: 160 aa. Conserved protein%2C equivalent to Q9CCI6|ML0781 hypothetical protein from Mycobacterium leprae (160 aa)%2C FASTA scores: opt: 828%2CE(): 1.5e-45%2C (80.6%25 identity in 160 aa overlap)%3B and similar to other hypothetical bacterial proteins and more weakly to putative potassium channels e.g. Q9RV81|DR1148 conserved hypothetical protein from Deinococcus radiodurans (175 aa)%2C FASTA scores: opt: 420%2C E(): 9.5e-20%2C (37.95%25 identity in 158 aa overlap)%3B O69959|SC4H2.04c hypothetical 17.1 KDA protein from Streptomyces coelicolor (161 aa)%2CFASTA scores: opt: 315%2C E(): 3.8e-13%2C (40.0%25 identity in 150 aa overlap)%3B Q9HNH3|PCHB|VNG2104G potassium channel homolog from Halobacterium sp. strain NRC-1 (418 aa)%2C FASTA scores: opt: 158%2C E(): 0.007%2C (31.45%25 identity in 124 aa overlap)%3B Q58752|YD57_METJA|MJ1357 putative potassium channel protein from Methanococcus jannaschii (343 aa)%2CFASTA scores: opt: 143%2C E(): 0.053%2C (33.8%25 identity in 68 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3237c;product=Conserved protein;protein_id=CCP46056.1;transl_table=11
AL123456.3	EMBL	gene	3613664	3614398	.	-	.	ID=gene-Rv3238c;Name=Rv3238c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3238c
AL123456.3	EMBL	CDS	3613664	3614398	.	-	0	ID=cds-CCP46057.1;Parent=gene-Rv3238c;Dbxref=EnsemblGenomes-Gn:Rv3238c,EnsemblGenomes-Tr:CCP46057,InterPro:IPR009915,UniProtKB/TrEMBL:O05883,NCBI_GP:CCP46057.1;Name=CCP46057.1;Note=Rv3238c%2C (MTCY20B11.13c)%2C len: 244 aa. Probable conserved integral membrane protein%2C similar to several hypothetical proteins and transmembrane proteins e.g. Q9UN92|NRM29 multispanning nuclear envelope membrane protein NURIM (fragment) from Homo sapiens (Human) (261 aa)%2C FASTA scores: opt: 281%2C E(): 3.3e-11%2C (30.7%25 identity in 189 aa overlap)%3B Q9VEG9|CG7655 hypothetical protein from Drosophila melanogaster (Fruit fly) (253 aa)%2C FASTA scores: opt: 242%2C E(): 1.1e-08%2C (27.7%25 identity in 242 aa overlap)%3B BAB48937|MLR1600 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (222 aa)%2C FASTA scores: opt: 137%2C E(): 0.066%2C (28.1%25 identity in 185 aa overlap)%3B BAB57936|SAV1774 aesenical pump membrane protein homolog from Staphylococcus aureus subsp. aureus Mu50 (430 aa)%2C FASTA scores: opt: 125%2CE(): 0.68%2C (25.7%25 identity in 144 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3238c;product=Probable conserved integral membrane protein;protein_id=CCP46057.1;transl_table=11
AL123456.3	EMBL	gene	3614457	3617603	.	-	.	ID=gene-Rv3239c;Name=Rv3239c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3239c
AL123456.3	EMBL	CDS	3614457	3617603	.	-	0	ID=cds-CCP46058.1;Parent=gene-Rv3239c;Dbxref=EnsemblGenomes-Gn:Rv3239c,EnsemblGenomes-Tr:CCP46058,GOA:O05884,InterPro:IPR000595,InterPro:IPR001411,InterPro:IPR001423,InterPro:IPR002641,InterPro:IPR004638,InterPro:IPR005829,InterPro:IPR011701,InterPro:IPR014710,InterPro:IPR016035,InterPro:IPR016196,InterPro:IPR018488,InterPro:IPR018490,InterPro:IPR020846,UniProtKB/TrEMBL:O05884,NCBI_GP:CCP46058.1;Name=CCP46058.1;Note=Rv3239c%2C (MTCY20B11.14c)%2C len: 1048 aa. Probable conserved transmembrane protein%2C organised in two domains. Domain comprising first ~~500 aa residues is similar to various antibiotic resistance and efflux proteins and contains sugar transport proteins signature 1 (PS00216)%3B e.g. Q9RL22|SC5G9.04c putative transmembrane efflux protein from Streptomyces coelicolor (489 aa)%2C FASTA scores: opt: 905%2C E(): 3.1e-41%2C (36.95%25 identity in 482 aa overlap)%3B and O68912|FRNF putative antibiotic antiporter from Streptomyces roseofulvus (517 aa)%2C FASTA scores: opt: 866%2CE(): 4.1e-39%2C (37.1%25 identity in 512 aa overlap). Second part%2C corresponding to last 550 aa residues%2C is very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kDa protein from Mycobacterium tuberculosis (583 aa)%2C FASTA scores: E(): 2.1e-28%2C (36.5%25 identity in 572 aa overlap). Also equivalent to Rv3728|MTV025.076 putative two-domain membrane protein (similar to sugar transporter family) from Mycobacterium tuberculosis (1065 aa)%2C FASTA scores: opt: 4328%2C E(): 0%2C (64.15%25 identity in 1046 aa overlap)%3B and similar to other Mycobacterium tuberculosis proteins: MTCY3G12.01%2C E(): 6.3e-32%3B MTCY98.02c%2C E(): 6.3e-32%3B MTCY9C4.03c%2C E(): 1.5e-26%3B MTCY369.27c%2C E(): 2.5e-26. Equivalent to AAK47679 Drug transporter from Mycobacterium tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa. Contains cyclic nucleotide-binding domain signature 2 (PS00889). Probably member of major facilitator superfamily (MFS).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00889;locus_tag=Rv3239c;product=Probable conserved transmembrane transport protein;protein_id=CCP46058.1;transl_table=11
AL123456.3	EMBL	gene	3617682	3620531	.	-	.	ID=gene-Rv3240c;Name=secA1;gbkey=Gene;gene=secA1;gene_biotype=protein_coding;gene_synonym=secA;locus_tag=Rv3240c
AL123456.3	EMBL	CDS	3617682	3620531	.	-	0	ID=cds-CCP46059.1;Parent=gene-Rv3240c;Dbxref=EnsemblGenomes-Gn:Rv3240c,EnsemblGenomes-Tr:CCP46059,GOA:P9WGP5,InterPro:IPR000185,InterPro:IPR011115,InterPro:IPR011116,InterPro:IPR011130,InterPro:IPR014018,InterPro:IPR020937,InterPro:IPR027417,PDB:1NKT,PDB:1NL3,NCBI_GP:CCP46059.1;Name=CCP46059.1;Note=Rv3240c%2C (MTCY20B11.15c)%2C len: 949 aa. Probable secA1%2C preprotein translocase subunit%2C component of secretion apparatus (see citations below)%2C highly similar to many e.g. P57996|SEA1_MYCLE from Mycobacterium leprae (940 aa)%2C FASTA scores: opt: 5044%2C E(): 0%2C (87.5%25 identity in 849 aa overlap)%3B P95759|SECA_STRGR from Streptomyces griseus (940 aa)%2C FASTA scores: opt: 2612%2C E(): 1.9e-134%2C(61.35%25 identity in 960 aa overlap)%3B P28366|SECA_BACSU|div+ from Bacillus subtilis (841 aa)%2C FASTA scores: opt: 1776%2CE(): 4.9e-89%2C (48.05%25 identity in 837 aa overlap)%3B etc. Belongs to the SecA family. Part of the prokaryotic protein translocation apparatus which comprise SECA%2C SECD|Rv2587c%2CSECE|Rv0638%2C SECF|Rv2586c%2C SECG|Rv1440 and SECY|Rv0732. Note that previously known as secA. Binds ATP.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=secA1;locus_tag=Rv3240c;product=Probable preprotein translocase SecA1 1 subunit;protein_id=CCP46059.1;transl_table=11
AL123456.3	EMBL	gene	3620610	3621254	.	-	.	ID=gene-Rv3241c;Name=Rv3241c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3241c
AL123456.3	EMBL	CDS	3620610	3621254	.	-	0	ID=cds-CCP46060.1;Parent=gene-Rv3241c;Dbxref=EnsemblGenomes-Gn:Rv3241c,EnsemblGenomes-Tr:CCP46060,GOA:O05886,InterPro:IPR003489,UniProtKB/TrEMBL:O05886,NCBI_GP:CCP46060.1;Name=CCP46060.1;Note=Rv3241c%2C (MTCY20B11.16c)%2C len: 214 aa. Conserved protein%2C similar to many hypothetical proteins and to some putative ribosomal proteins e.g. Q9CCI7|ML0778 hypothetical protein from Mycobacterium leprae (229 aa)%2C FASTA scores: opt: 1234%2C E(): 1.3e-72%2C (89.3%25 identity in 206 aa overlap)%3B Q9KYX2|SCE33.11c hypothetical 27.9 KDA protein from Streptomyces coelicolor (254 aa)%2C FASTA scores: opt: 487%2C E(): 2.2e-24%2C (47.6%25 identity in 210 aa overlap)%3B Q9FLV3 protein similar to ribosomal protein 30S subunit from Arabidopsis thaliana (Mouse-ear cress) (365 aa)%2C FASTA scores: opt: 264%2C E(): 7e-10%2C (26.4%25 identity in 212 aa overlap)%3B P19954|RR30_SPIOL|RPS22 plastid-specific 30S ribosomal protein 1%2C chloroplast%2C from Spinacia oleracea (Spinach) (302 aa)%2C FASTA scores: opt: 261%2C E(): 9.3e-10%2C(26.15%25 identity in 214 aa overlap)%3B P47995|YSEA_STACA hypothetical protein in SECA 5'region (ORF1) (fragment) (belongs to the S30AE family of ribosomal proteins) from Staphylococcus carnosus (165 aa)%2C FASTA scores: opt: 201%2CE(): 4.2e-06%2C (33.35%25 identity in 147 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3241c;product=Conserved protein;protein_id=CCP46060.1;transl_table=11
AL123456.3	EMBL	gene	3621570	3622211	.	-	.	ID=gene-Rv3242c;Name=Rv3242c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3242c
AL123456.3	EMBL	CDS	3621570	3622211	.	-	0	ID=cds-CCP46061.1;Parent=gene-Rv3242c;Dbxref=EnsemblGenomes-Gn:Rv3242c,EnsemblGenomes-Tr:CCP46061,InterPro:IPR029057,UniProtKB/TrEMBL:O05887,NCBI_GP:CCP46061.1;Name=CCP46061.1;Note=Rv3242c%2C (MTCY20B11.17c)%2C len: 213 aa. Conserved hypothetical protein%2C highly similar in N-terminus to Q9CCI9|ML0776 hypothetical protein from Mycobacterium leprae (85 aa)%2C FASTA scores: opt: 324%2C E(): 1.7e-13%2C(78.1%25 identity in 64 aa overlap). Also similar to Q9RUJ7|DR1389 putative competence protein COMF from Deinococcus radiodurans (219 aa)%2C FASTA scores: opt: 223%2CE(): 6.3e-07%2C (35.8%25 identity in 215 aa overlap)%3B BAB50338|MLL3453 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (240 aa)%2C FASTA scores: opt: 218%2C E(): 1.4e-06%2C (28.5%25 identity in 224 aa overlap)%3B Q9A9Y1|CC0830 competence protein F from Caulobacter crescentus (265 aa)%2CFASTA scores: opt: 182%2C E(): 0.00026%2C (30.15%25 identity in 219 aa overlap)%3B etc. Equivalent to AAK47682 from Mycobacterium tuberculosis strain CDC1551 (241 aa) but shorter 29 aa. Contains purine/pyrimidine phosphoribosyl transferases signature (PS00103). Seems to belong to purine/pyrimidine phosphoribosyl transferase family.;gbkey=CDS;inference=protein motif:PROSITE:PS00103;locus_tag=Rv3242c;product=Conserved hypothetical protein;protein_id=CCP46061.1;transl_table=11
AL123456.3	EMBL	gene	3622249	3623091	.	-	.	ID=gene-Rv3243c;Name=Rv3243c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3243c
AL123456.3	EMBL	CDS	3622249	3623091	.	-	0	ID=cds-CCP46062.1;Parent=gene-Rv3243c;Dbxref=EnsemblGenomes-Gn:Rv3243c,EnsemblGenomes-Tr:CCP46062,GOA:O05888,InterPro:IPR021373,UniProtKB/TrEMBL:O05888,NCBI_GP:CCP46062.1;Name=CCP46062.1;Note=Rv3243c%2C (MTCY20B11.18c)%2C len: 280 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3243c;product=Unknown protein;protein_id=CCP46062.1;transl_table=11
AL123456.3	EMBL	gene	3623159	3624910	.	-	.	ID=gene-Rv3244c;Name=lpqB;gbkey=Gene;gene=lpqB;gene_biotype=protein_coding;locus_tag=Rv3244c
AL123456.3	EMBL	CDS	3623159	3624910	.	-	0	ID=cds-CCP46063.1;Parent=gene-Rv3244c;Dbxref=EnsemblGenomes-Gn:Rv3244c,EnsemblGenomes-Tr:CCP46063,GOA:P9WK37,InterPro:IPR018910,InterPro:IPR019606,InterPro:IPR023959,NCBI_GP:CCP46063.1;Name=CCP46063.1;Note=Rv3244c%2C (MTCY20B11.19c)%2C len: 583 aa. Probable lpqB%2C conserved lipoprotein%3B contains appropriately placed lipoprotein signature (PS00013). Equivalent to Q9CCJ0|LPQB|ML0775 putative lipoprotein from Mycobacterium leprae (589 aa)%2C FASTA scores: opt: 3375%2C E(): 1.4e-186%2C(87.9%25 identity in 579 aa overlap). Also similar to various proteins (in particular transferases) e.g. Q9KYX0|SCE33.13c putative lipoprotein from Streptomyces coelicolor (615 aa)%2CFASTA scores: opt: 228%2C E(): 1.3e-05%2C (25.5%25 identity in 624 aa overlap)%3B O87992|BBLPS1.19c putative glutamine amidotransferase from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (628 aa)%2C FASTA scores: opt: 162%2C E(): 0.079%2C (28.05%25 identity in 171 aa overlap)%3B Q9L2F4|SC7A8.01 putative sugar kinase (fragment) from Streptomyces coelicolor (434 aa)%2C FASTA scores: opt: 143%2CE(): 0.72%2C (27.65%25 identity in 293 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqB;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3244c;product=Probable conserved lipoprotein LpqB;protein_id=CCP46063.1;transl_table=11
AL123456.3	EMBL	gene	3624910	3626613	.	-	.	ID=gene-Rv3245c;Name=mtrB;gbkey=Gene;gene=mtrB;gene_biotype=protein_coding;locus_tag=Rv3245c
AL123456.3	EMBL	CDS	3624910	3626613	.	-	0	ID=cds-CCP46064.1;Parent=gene-Rv3245c;Dbxref=EnsemblGenomes-Gn:Rv3245c,EnsemblGenomes-Tr:CCP46064,GOA:P9WGK9,InterPro:IPR003594,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR009082,NCBI_GP:CCP46064.1;Name=CCP46064.1;Note=Rv3245c%2C (MTCY20B11.20c)%2C len: 567 aa. MtrB%2Csensor-like histidine kinase (see citations below)%2Cequivalent to Q9CCJ1|MTRB or ML0774 putative two-component system sensor kinase from Mycobacterium leprae (562 aa)%2CFASTA scores: opt: 3208%2C E(): 7.4e-173%2C (88.7%25 identity in 566 aa overlap). Also similar to others e.g. Q9KYW9|SCE33.14c putative two-component system histidine kinase from Streptomyces coelicolor (688 aa)%2C FASTA scores: opt: 1355%2C E(): 1.1e-68%2C (48.95%25 identity in 515 aa overlap)%3B etc. Relatives in Mycobacterium tuberculosis are: MTCY369.03%2C E(): 1.5e-22%3B MTCY20G9.16%2C E(): 1.9e-17. Similar to other prokaryotic sensory transduction histidine kinases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mtrB;locus_tag=Rv3245c;product=Two component sensory transduction histidine kinase MtrB;protein_id=CCP46064.1;transl_table=11
AL123456.3	EMBL	repeat_region	3626614	3626666	.	-	.	ID=id-AL123456.3:3626614..3626666;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	3626663	3627349	.	-	.	ID=gene-Rv3246c;Name=mtrA;gbkey=Gene;gene=mtrA;gene_biotype=protein_coding;locus_tag=Rv3246c
AL123456.3	EMBL	CDS	3626663	3627349	.	-	0	ID=cds-CCP46065.1;Parent=gene-Rv3246c;Dbxref=EnsemblGenomes-Gn:Rv3246c,EnsemblGenomes-Tr:CCP46065,GOA:P9WGM7,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,PDB:2GWR,PDB:3NHZ,NCBI_GP:CCP46065.1;Name=CCP46065.1;Note=Rv3246c%2C (MTCY20B11.21c)%2C len: 228 aa. MtrA%2Ctranscriptional activator%2C response regulator (see citations below)%2C equivalent to Q9CCJ2|MTRA|ML0773 putative two-component response regulator from Mycobacterium leprae (228 aa)%2C FASTA scores: opt: 1458%2C E(): 1.4e-85%2C (98.7%25 identity in 228 aa overlap). Also highly similar to others e.g. Q9F9J5|SCRA putative response regulator from Streptomyces coelicolor (228 aa)%2C FASTA scores: opt: 1141%2CE(): 1.9e-65%2C (74.9%25 identity in 227 aa overlap)%3B Q9KYW8|SCE33.15c putative two-component system response regulator from Streptomyces coelicolor (229 aa)%2C FASTA scores: opt: 1141%2C E(): 1.9e-65%2C (74.9%25 identity in 227 aa overlap)%3B Q9F868|REGX3 response regulator REGX3 from Mycobacterium smegmatis (228 aa)%2C FASTA scores: opt: 730%2CE(): 2.3e-39%2C (50.90%25 identity in 222 aa overlap)%3B etc. Relatives in Mycobacterium tuberculosis are: U01971|MTU01971_1%3B Q11156|RGX3_MYCTU%3B MTCY20G9.17%2C E(): 0%3B MTCY31.31c%2C E(): 3.4e-29%3B MTCY369.02%2C E(): 5.7e-28. Similar to bacterial regulatory proteins involved in signal transduction. The N-terminal region is similar to that of other regulatory components of sensory transduction systems. Experiments showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mtrA;locus_tag=Rv3246c;product=Two component sensory transduction transcriptional regulatory protein MtrA;protein_id=CCP46065.1;transl_table=11
AL123456.3	EMBL	gene	3627419	3628063	.	-	.	ID=gene-Rv3247c;Name=tmk;gbkey=Gene;gene=tmk;gene_biotype=protein_coding;locus_tag=Rv3247c
AL123456.3	EMBL	CDS	3627419	3628063	.	-	0	ID=cds-CCP46066.1;Parent=gene-Rv3247c;Dbxref=EnsemblGenomes-Gn:Rv3247c,EnsemblGenomes-Tr:CCP46066,GOA:P9WKE1,InterPro:IPR018094,InterPro:IPR018095,InterPro:IPR027417,PDB:1G3U,PDB:1GSI,PDB:1GTV,PDB:1MRN,PDB:1MRS,PDB:1N5I,PDB:1N5J,PDB:1N5K,PDB:1N5L,PDB:1W2G,PDB:1W2H,NCBI_GP:CCP46066.1;Name=CCP46066.1;Note=Rv3247c%2C (MTCY20B11.22c)%2C len: 214 aa. tmk%2Cthymidylate kinase%2C equivalent to Q9CCJ3|TMK|ML0772 putative thymidylate kinase from Mycobacterium leprae (210 aa)%2C FASTA scores: opt: 1023%2C E(): 4.8e-57%2C (77.3%25 identity in 207 aa overlap). Also similar to other thymidylate kinases e.g. Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from Caulobacter crescentus (208 aa)%2C FASTA scores: opt: 179%2C E(): 0.0003%2C(31.3%25 identity in 214 aa overlap)%3B Q9V1E9|KTHY_PYRAB|TMK|PAB0319 from Pyrococcus abyssi (205 aa)%2C FASTA scores: opt: 176%2C E(): 0.00045%2C (29.1%25 identity in 189 aa overlap)%3B etc. Belongs to the thymidylate kinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tmk;locus_tag=Rv3247c;product=Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK);protein_id=CCP46066.1;transl_table=11
AL123456.3	EMBL	gene	3628160	3629647	.	-	.	ID=gene-Rv3248c;Name=sahH;gbkey=Gene;gene=sahH;gene_biotype=protein_coding;locus_tag=Rv3248c
AL123456.3	EMBL	CDS	3628160	3629647	.	-	0	ID=cds-CCP46067.1;Parent=gene-Rv3248c;Dbxref=EnsemblGenomes-Gn:Rv3248c,EnsemblGenomes-Tr:CCP46067,GOA:P9WGV3,InterPro:IPR000043,InterPro:IPR015878,InterPro:IPR016040,InterPro:IPR020082,PDB:2ZIZ,PDB:2ZJ0,PDB:2ZJ1,PDB:3CE6,PDB:3DHY,NCBI_GP:CCP46067.1;Name=CCP46067.1;Note=Rv3248c%2C (MTCY20B11.23c)%2C len: 495 aa. Probable sahH%2C adenosylhomocysteinase%2C equivalent to Q9CCJ4|SAHH|ML0771 putative S-adenosyl-L-homocysteine hydrolase from Mycobacterium leprae (492 aa)%2C FASTA scores: opt: 3019%2C E(): 1.3e-177%2C (91.4%25 identity in 489 aa overlap). Also highly similar to other adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces coelicolor (485 aa)%2C FASTA scores: opt: 2258%2C E(): 5.7e-131%2C (70.0%25 identity in 483 aa overlap)%3B P51540|SAHH_TRIVA from Trichomonas vaginalis (486 aa)%2CFASTA scores: opt: 2005%2C E(): 1.8e-115%2C (62.05%25 identity in 477 aa overlap)%3B P35007|SAHH_CATRO from Catharanthus roseus (Rosy periwinkle) (Madagascar periwinkle) (485 aa)%2C FASTA scores: opt: 1941%2C E(): 1.5e-111%2C (60.15%25 identity in 492 aa overlap)%3B etc. Has S-adenosyl-L-homocysteine hydrolase signature (PS00739). Belongs to the adenosylhomocysteinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sahH;inference=protein motif:PROSITE:PS00739;locus_tag=Rv3248c;product=Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase);protein_id=CCP46067.1;transl_table=11
AL123456.3	EMBL	gene	3629752	3630387	.	-	.	ID=gene-Rv3249c;Name=Rv3249c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3249c
AL123456.3	EMBL	CDS	3629752	3630387	.	-	0	ID=cds-CCP46068.1;Parent=gene-Rv3249c;Dbxref=EnsemblGenomes-Gn:Rv3249c,EnsemblGenomes-Tr:CCP46068,GOA:O05892,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:O05892,NCBI_GP:CCP46068.1;Name=CCP46068.1;Note=Rv3249c%2C (MTCY20B11.24c)%2C len: 211 aa. Possible transcriptional regulatory protein%2C TetR family%2C with similarity to several e.g. Q9AE61|ALKB1 putative TetR-regulatory from Rhodococcus erythropolis (208 aa)%2CFASTA scores: opt: 503%2C E(): 7.7e-26%2C (40.6%25 identity in 192 aa overlap)%3B CAC37620 putative TetR-regulatory protein from Prauserella rugosa (212 aa)%2C FASTA scores: opt: 246%2CE(): 4.4e-09%2C (27.95%25 identity in 186 aa overlap)%3B Q9K4B0|SC7E4.06 putative TetR-family transcriptional from Streptomyces coelicolor (203 aa)%2C FASTA scores: opt: 224%2CE(): 1.1e-07%2C (34.5%25 identity in 197 aa overlap)%3B Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.27 hypothetical transcriptional regulator from Mycobacterium tuberculosis (202 aa)%2C FASTA scores: opt: 191%2C E(): 1.6e-05%2C (28.35%25 identity in 180 aa overlap)%3B etc. Equivalent to AAK47689 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 19 aa. Could belong to the TetR/AcrR family of transcriptional regulators. Possible helix-turn helix motif at aa 44-65 (+6.66 SD).;gbkey=CDS;locus_tag=Rv3249c;product=Possible transcriptional regulatory protein (probably TetR-family);protein_id=CCP46068.1;transl_table=11
AL123456.3	EMBL	gene	3630384	3630566	.	-	.	ID=gene-Rv3250c;Name=rubB;gbkey=Gene;gene=rubB;gene_biotype=protein_coding;locus_tag=Rv3250c
AL123456.3	EMBL	CDS	3630384	3630566	.	-	0	ID=cds-CCP46069.1;Parent=gene-Rv3250c;Dbxref=EnsemblGenomes-Gn:Rv3250c,EnsemblGenomes-Tr:CCP46069,GOA:I6YFL7,InterPro:IPR004039,InterPro:IPR018527,InterPro:IPR024934,InterPro:IPR024935,UniProtKB/TrEMBL:I6YFL7,NCBI_GP:CCP46069.1;Name=CCP46069.1;Note=Rv3250c%2C (MTCY20B11.25c)%2C len: 60 aa. Probable rubB%2Crubredoxin%2C highly similar to other rubredoxins e.g. Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa)%2C FASTA scores: opt: 391%2C E(): 2.2e-21%2C (83.05%25 identity in 59 aa overlap)%3B Q9AE63|RUBA2 from Rhodococcus erythropolis (63 aa)%2C FASTA scores: opt: 380%2C E(): 1.4e-20%2C (83.9%25 identity in 56 aa overlap)%3B P42453|RUBR_ACICA|RUBA from Acinetobacter calcoaceticus (54 aa)%2C FASTA scores: opt: 315%2C E(): 4.9e-16%2C (69.8%25 identity in 53 aa overlap)%3B Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa)%2C FASTA scores: opt: 298%2C E(): 8e-15%2C (64.15%25 identity in 53 aa overlap)%3B Q9PGC3|XF0379 from Xylella fastidiosa (57 aa)%2CFASTA scores: opt: 263%2C E(): 2.5e-12%2C (59.25%25 identity in 54 aa overlap)%3B etc. Also similar to neighbouring ORF M. tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin signature (PS00202). Belongs to the rubredoxin family.;gbkey=CDS;gene=rubB;inference=protein motif:PROSITE:PS00202;locus_tag=Rv3250c;product=Probable rubredoxin RubB;protein_id=CCP46069.1;transl_table=11
AL123456.3	EMBL	gene	3630571	3630738	.	-	.	ID=gene-Rv3251c;Name=rubA;gbkey=Gene;gene=rubA;gene_biotype=protein_coding;locus_tag=Rv3251c
AL123456.3	EMBL	CDS	3630571	3630738	.	-	0	ID=cds-CCP46070.1;Parent=gene-Rv3251c;Dbxref=EnsemblGenomes-Gn:Rv3251c,EnsemblGenomes-Tr:CCP46070,GOA:O05894,InterPro:IPR004039,InterPro:IPR018527,InterPro:IPR024934,InterPro:IPR024935,UniProtKB/TrEMBL:O05894,NCBI_GP:CCP46070.1;Name=CCP46070.1;Note=Rv3251c%2C (MTCY20B11.26c)%2C len: 55 aa. Probable rubA%2Crubredoxin%2C highly similar to other rubredoxins (but sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus erythropolis (61 aa)%2C FASTA scores: opt: 335%2C E(): 1e-17%2C(73.6%25 identity in 53 aa overlap)%3B P00272|RUB2_PSEOL|ALKG from Pseudomonas oleovorans (172 aa)%2C FASTA scores: opt: 278%2C E(): 2.7e-13%2C (65.3%25 identity in 49 aa overlap)%3B CAC38028|ALKG from Alcanivorax borkumensis (174 aa)%2C FASTA scores: opt: 271%2C E(): 8.6e-13%2C (62.0%25 identity in 50 aa overlap)%3B Q9WWW4|ALKG from Pseudomonas putida (175 aa)%2CFASTA scores: opt: 270%2C E(): 1e-12%2C (61.8%25 identity in 55 aa overlap)%3B etc. Also highly similar to C-terminus of Q9XBM1|ALKB alkane 1-monooxygenase from Prauserella rugosa (490 aa)%2C FASTA scores: opt: 296%2C E(): 2.9e-14%2C (75.5%25 identity in 49 aa overlap). Also similar to neighbouring ORF Mycobacterium tuberculosis rubB (MTCY20B11.25c). Contains rubredoxin signature (PS00202). Belongs to the rubredoxin family.;gbkey=CDS;gene=rubA;inference=protein motif:PROSITE:PS00202;locus_tag=Rv3251c;product=Probable rubredoxin RubA;protein_id=CCP46070.1;transl_table=11
AL123456.3	EMBL	gene	3630738	3631988	.	-	.	ID=gene-Rv3252c;Name=alkB;gbkey=Gene;gene=alkB;gene_biotype=protein_coding;locus_tag=Rv3252c
AL123456.3	EMBL	CDS	3630738	3631988	.	-	0	ID=cds-CCP46071.1;Parent=gene-Rv3252c;Dbxref=EnsemblGenomes-Gn:Rv3252c,EnsemblGenomes-Tr:CCP46071,GOA:O05895,InterPro:IPR005804,UniProtKB/TrEMBL:O05895,NCBI_GP:CCP46071.1;Name=CCP46071.1;Note=Rv3252c%2C (MTCY20B11.27c)%2C len: 416 aa. Probable alkB%2C transmembrane alkane-1-monooxygenase%2C highly similar to many (see Marin et al.%2C 2001) e.g. Q9AE68|ALKB2 from Rhodococcus erythropolis (408 aa)%2C FASTA scores: opt: 2018%2CE(): 9.6e-122%2C (68.6%25 identity in 415 aa overlap)%3B Q9AFD5|ALKB from Nocardioides sp. CF8 (483 aa)%2C FASTA scores: opt: 1485%2C E(): 1.4e-87%2C (56.55%25 identity in 405 aa overlap)%3B Q9XAU0|ALKB1 from Rhodococcus erythropolis (391 aa)%2C FASTA scores: opt: 1400%2C E(): 3.3e-82%2C (62.6%25 identity in 396 aa overlap)%3B Q9XBM1|ALKB from Prauserella rugosa (490 aa)%2C FASTA scores: opt: 1266%2C E(): 1.5e-73%2C (57.55%25 identity in 410 aa overlap)%3B CAC40954|ALKB4 from Rhodococcus erythropolis (386 aa)%2C FASTA scores: opt: 1190%2CE(): 9.1e-69%2C (54.3%25 identity in 383 aa overlap)%3B etc.;gbkey=CDS;gene=alkB;locus_tag=Rv3252c;product=Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (fatty acid omega-hydroxylase) (alkane hydroxylase-rubredoxin);protein_id=CCP46071.1;transl_table=11
AL123456.3	EMBL	gene	3632097	3633584	.	-	.	ID=gene-Rv3253c;Name=Rv3253c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3253c
AL123456.3	EMBL	CDS	3632097	3633584	.	-	0	ID=cds-CCP46072.1;Parent=gene-Rv3253c;Dbxref=EnsemblGenomes-Gn:Rv3253c,EnsemblGenomes-Tr:CCP46072,GOA:O05896,InterPro:IPR002293,UniProtKB/TrEMBL:O05896,NCBI_GP:CCP46072.1;Name=CCP46072.1;Note=Rv3253c%2C (MTCY20B11.28c)%2C len: 495 aa. Possible cationic amino acid transporter%2C integral membrane protein%2Csimilar to many e.g. O69844|SC1C3.02 putative cationic amino acid transporter from Streptomyces coelicolor (503 aa)%2C FASTA scores: opt: 1649%2C E(): 5.8e-92%2C (52.6%25 identity in 485 aa overlap)%3B Q9AE69 putative transporter (fragment) from Rhodococcus erythropolis (385 aa)%2C FASTA scores: opt: 1594%2C E(): 9.7e-89%2C (62.0%25 identity in 387 aa overlap)%3B Q9PBD7|XF2207 cationic amino acid transporter from Xylella fastidiosa (483 aa)%2C FASTA scores: opt: 1079%2C E(): 1.2e-57%2C(40.55%25 identity in 493 aa overlap)%3B Q9SRU9|F20H23.25 putative cationic amino acid transporter from Arabidopsis thaliana (Mouse-ear cress) (614 aa)%2C FASTA scores: opt: 802%2C E(): 6.7e-41%2C (36.4%25 identity in 445 aa overlap)%3B P30823|CTR1_RAT|SLC7A1|ATRC1 high-affinity cationic amino acid transporter-1 from Rattus norvegicus (Rat) (624 aa)%2CFASTA scores: opt: 782%2C E(): 1.1e-39%2C (36.1%25 identity in 432 aa overlap)%3B etc. Relatives in Mycobacterium tuberculosis include: MTCY3G12.14%2C E(): 5.6e-31%3B MTCY39.19%2CE(): 1.6e-14. Seems to belong to the APC family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3253c;product=Possible cationic amino acid transport integral membrane protein;protein_id=CCP46072.1;transl_table=11
AL123456.3	EMBL	gene	3633675	3635063	.	+	.	ID=gene-Rv3254;Name=Rv3254;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3254
AL123456.3	EMBL	CDS	3633675	3635063	.	+	0	ID=cds-CCP46073.1;Parent=gene-Rv3254;Dbxref=EnsemblGenomes-Gn:Rv3254,EnsemblGenomes-Tr:CCP46073,GOA:O05897,UniProtKB/TrEMBL:O05897,NCBI_GP:CCP46073.1;Name=CCP46073.1;Note=Rv3254%2C (MTCY20B11.29)%2C len: 462 aa. Conserved hypothetical protein%2C similar to CAC37877|SC1G7.02 putative secreted protein from Streptomyces coelicolor (440 aa)%2CFASTA scores: opt: 606%2C E(): 6.2e-31%2C (31.7%25 identity in 445 aa overlap)%3B O86550|SC1F2.13c hypothetical 50.7 KDA protein from Streptomyces coelicolor (476 aa)%2C FASTA scores: opt: 577%2C E(): 4.5e-29%2C (32.5%25 identity in 400 aa overlap)%3B Q9L0A8|SCC24.09 putative secreted protein from Streptomyces coelicolor (468 aa)%2C FASTA scores: opt: 380%2CE(): 1.3e-16%2C (30.7%25 identity in 391 aa overlap)%3B BAB48792|MLL1411 probable FAD-dependent monooxygenase from Rhizobium loti (Mesorhizobium loti) (421 aa)%2C FASTA scores: opt: 128%2C E(): 1.1%2C (25.2%25 identity in 397 aa overlap)%3B Q9L7X9|BENF benzoate-specific porin-like protein from Pseudomonas putida (397 aa)%2C FASTA scores: opt: 119%2C E(): 4%2C (24.85%25 identity in 157 aa overlap)%3B etc. Also similar to N-terminus of AAK46259|MT1987 putative ferredoxin reductase%2C electron transfer component from Mycobacterium tuberculosis strain CDC1551 (839 aa)%2C FASTA scores: opt: 493%2C E(): 1.5e-23%2C (30.65%25 identity in 382 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3254;product=Conserved hypothetical protein;protein_id=CCP46073.1;transl_table=11
AL123456.3	EMBL	gene	3635041	3636267	.	-	.	ID=gene-Rv3255c;Name=manA;gbkey=Gene;gene=manA;gene_biotype=protein_coding;locus_tag=Rv3255c
AL123456.3	EMBL	CDS	3635041	3636267	.	-	0	ID=cds-CCP46074.1;Parent=gene-Rv3255c;Dbxref=EnsemblGenomes-Gn:Rv3255c,EnsemblGenomes-Tr:CCP46074,GOA:O05898,InterPro:IPR001250,InterPro:IPR011051,InterPro:IPR014710,InterPro:IPR016305,UniProtKB/TrEMBL:O05898,NCBI_GP:CCP46074.1;Name=CCP46074.1;Note=Rv3255c%2C (MTCY20B11.30c)%2C len: 408 aa. Probable manA%2C mannose-6-phosphate isomerase%2C equivalent to Q9CCJ5|MANA|ML0765 putative mannose-6-phosphate isomerase from Mycobacterium leprae (410 aa)%2C FASTA scores: opt: 2271%2C E(): 1.6e-133%2C (84.45%25 identity in 411 aa overlap). Also similar to many others e.g. Q9KZL9|MANA from Streptomyces coelicolor (383 aa)%2C FASTA scores: opt: 946%2CE(): 2.4e-51%2C (44.4%25 identity in 403 aa overlap)%3B Q9KV87|VC0269 from Vibrio cholerae (399 aa)%2C FASTA scores: opt: 726%2C E(): 1.1e-37%2C (34.15%25 identity in 404 aa overlap)%3B Q9CMJ5|PMI|PM0829 from Pasteurella multocida (400 aa)%2C FASTA scores: opt: 640%2C E(): 2.4e-32%2C (32.5%25 identity in 391 aa overlap)%3B etc. Similar to family 1 of mannose-6-phosphate isomerases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=manA;locus_tag=Rv3255c;product=Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (phosphohexomutase);protein_id=CCP46074.1;transl_table=11
AL123456.3	EMBL	gene	3636275	3637315	.	-	.	ID=gene-Rv3256c;Name=Rv3256c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3256c
AL123456.3	EMBL	CDS	3636275	3637315	.	-	0	ID=cds-CCP46075.1;Parent=gene-Rv3256c;Dbxref=EnsemblGenomes-Gn:Rv3256c,EnsemblGenomes-Tr:CCP46075,GOA:O05899,UniProtKB/TrEMBL:O05899,NCBI_GP:CCP46075.1;Name=CCP46075.1;Note=Rv3256c%2C (MTV015.01c-MTCY20B11.31c)%2C len: 346 aa. Conserved protein%2C equivalent to Q9CCJ6|ML0764 hypothetical protein from Mycobacterium leprae (365 aa)%2C FASTA scores: opt: 1574%2C E(): 1.4e-82%2C (75.35%25 identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa)%2C FASTA scores: opt: 171%2C E(): 0.012%2C (31.1%25 identity in 376 aa overlap)%3B P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa)%2C FASTA scores: opt: 140%2C E(): 0.84%2C (28.75%25 identity in 233 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3256c;product=Conserved protein;protein_id=CCP46075.1;transl_table=11
AL123456.3	EMBL	gene	3637312	3638709	.	-	.	ID=gene-Rv3257c;Name=pmmA;gbkey=Gene;gene=pmmA;gene_biotype=protein_coding;locus_tag=Rv3257c
AL123456.3	EMBL	CDS	3637312	3638709	.	-	0	ID=cds-CCP46076.1;Parent=gene-Rv3257c;Dbxref=EnsemblGenomes-Gn:Rv3257c,EnsemblGenomes-Tr:CCP46076,GOA:O86374,InterPro:IPR005841,InterPro:IPR005843,InterPro:IPR005844,InterPro:IPR005845,InterPro:IPR005846,InterPro:IPR016055,UniProtKB/TrEMBL:O86374,NCBI_GP:CCP46076.1;Name=CCP46076.1;Note=Rv3257c%2C (MTV015.02c)%2C len: 465 aa. Probable pmmA%2Cphosphomannomutase%2C equivalent to Q9CCJ7|PMMA|ML0763 phosphomannomutase from Mycobacterium leprae (468 aa)%2CFASTA scores: opt: 2533%2C E(): 2e-145%2C (83.1%25 identity in 468 aa overlap). Also similar to many e.g. Q9KZL6|MANB from Streptomyces coelicolor (454 aa)%2C FASTA scores: opt: 1820%2CE(): 2e-102%2C (63.2%25 identity in 459 aa overlap)%3B Q9PGN8|XF0260 from Xylella fastidiosa (500 aa)%2C FASTA scores: opt: 1085%2C E(): 4.7e-58%2C (40.7%25 identity in 462 aa overlap)%3B Q9EY19|MANB from Salmonella enterica subsp. arizonae (456 aa)%2C FASTA scores: opt: 988%2C E(): 3.1e-52%2C(38.65%25 identity in 445 aa overlap)%3B etc. Belongs to the phosphohexose mutases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pmmA;locus_tag=Rv3257c;product=Probable phosphomannomutase PmmA (PMM) (phosphomannose mutase);protein_id=CCP46076.1;transl_table=11
AL123456.3	EMBL	gene	3638811	3639302	.	-	.	ID=gene-Rv3258c;Name=Rv3258c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3258c
AL123456.3	EMBL	CDS	3638811	3639302	.	-	0	ID=cds-CCP46077.1;Parent=gene-Rv3258c;Dbxref=EnsemblGenomes-Gn:Rv3258c,EnsemblGenomes-Tr:CCP46077,InterPro:IPR021888,UniProtKB/TrEMBL:O53351,NCBI_GP:CCP46077.1;Name=CCP46077.1;Note=Rv3258c%2C (MTV015.03c)%2C len: 163 aa. Conserved hypothetical protein%2C equivalent to Q9CCJ8|ML0762 hypothetical protein from Mycobacterium leprae (165 aa)%2CFASTA scores: opt: 840%2C E(): 9.9e-42%2C (76.9%25 identity in 169 aa overlap). Also similar to Q9KZL4|SCE34.11c hypothetical 15.0 KDA protein from Streptomyces coelicolor (140 aa)%2C FASTA scores: opt: 353%2C E(): 1.1e-13%2C (48.3%25 identity in 147 aa overlap)%3B and shows really weak similarity to other bacterial proteins.;gbkey=CDS;locus_tag=Rv3258c;product=Conserved hypothetical protein;protein_id=CCP46077.1;transl_table=11
AL123456.3	EMBL	gene	3639425	3639844	.	+	.	ID=gene-Rv3259;Name=Rv3259;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3259
AL123456.3	EMBL	CDS	3639425	3639844	.	+	0	ID=cds-CCP46078.1;Parent=gene-Rv3259;Dbxref=EnsemblGenomes-Gn:Rv3259,EnsemblGenomes-Tr:CCP46078,InterPro:IPR010428,UniProtKB/TrEMBL:O53352,NCBI_GP:CCP46078.1;Name=CCP46078.1;Note=Rv3259%2C (MTV015.04)%2C len: 139 aa. Conserved hypothetical protein%2C equivalent%2C but shorter 29 aa%2C to Q9CCJ9|ML0761 hypothetical protein from Mycobacterium leprae (167 aa)%2C FASTA scores: opt: 846%2C E(): 2.2e-47%2C(89.2%25 identity in 139 aa overlap). C-terminus highly similar to Q9S425 hypothetical 6.0 KDA protein (fragment) from Mycobacterium smegmatis (54 aa)%2C FASTA scores: opt: 275%2C E(): 2.7e-11%2C (81.15%25 identity in 53 aa overlap). Also similar to Q9KZL3|SCE34.12 from Streptomyces coelicolor (117 aa)%2C FASTA scores: opt: 152%2C E(): 0.004%2C (34.15%25 identity in 126 aa overlap). Equivalent to AAK47699 from Mycobacterium tuberculosis strain CDC1551 (175 aa) but shorter 36 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv3259;product=Conserved hypothetical protein;protein_id=CCP46078.1;transl_table=11
AL123456.3	EMBL	gene	3639872	3640141	.	-	.	ID=gene-Rv3260c;Name=whiB2;gbkey=Gene;gene=whiB2;gene_biotype=protein_coding;gene_synonym=whmD;locus_tag=Rv3260c
AL123456.3	EMBL	CDS	3639872	3640141	.	-	0	ID=cds-CCP46079.1;Parent=gene-Rv3260c;Dbxref=EnsemblGenomes-Gn:Rv3260c,EnsemblGenomes-Tr:CCP46079,GOA:O53353,InterPro:IPR003482,NCBI_GP:CCP46079.1;Name=CCP46079.1;Note=Rv3260c%2C (MTV015.05c)%2C len: 89 aa. Probable whiB2 (alternate gene name: whmD)%2C WhiB-like regulatory protein (see Hutter %26 Dick 1999)%2C similar to WhiB paralogue of Streptomyces coelicolor%2C wblE gene product (85 aa). Equivalent to Q9CCK0|WHIB2|ML0760 putative transcriptional regulator from Mycobacterium leprae (89 aa)%2C FASTA scores: opt: 550%2C E(): 6.1e-31%2C (85.4%25 identity in 89 aa overlap). Also similar to others e.g. Q9S426 WHMD regulatory protein (see Gomez %26 Bishai 2000) from Mycobacterium smegmatis (129 aa)%2C FASTA scores: opt: 488%2C E(): 1.4e-26%2C (83.55%25 identity in 85 aa overlap)%3B Q06387|WHIB-STV WHIB-STV protein from Streptomyces griseocarneus (87 aa)%2C FASTA scores: opt: 443%2CE(): 1.2e-23%2C (74.7%25 identity in 83 aa overlap)%3B Q05429|WHIB|WHIB1 transcription-like factor WhiB from Streptomyces aureofaciens (87 aa)%2C FASTA scores: opt: 442%2CE(): 1.3e-23%2C (74.7%25 identity in 83 aa overlap)%3B etc. Equivalent to AAK47700 WhiB-related protein from Mycobacterium tuberculosis strain CDC1551 (123 aa) but shorter 34 aa. Also similar to other Mycobacterium tuberculosis proteins: MTCY07D11.07c (45.1%25 identity in 71 aa overlap) and MTCY78.13c (37.4%25 identity in 91 aa overlap). Start chosen by homology but ORF continues to ATG upstream at 3754.;gbkey=CDS;gene=whiB2;locus_tag=Rv3260c;product=Probable transcriptional regulatory protein WhiB-like WhiB2;protein_id=CCP46079.1;transl_table=11
AL123456.3	EMBL	gene	3640543	3641538	.	+	.	ID=gene-Rv3261;Name=fbiA;gbkey=Gene;gene=fbiA;gene_biotype=protein_coding;locus_tag=Rv3261
AL123456.3	EMBL	CDS	3640543	3641538	.	+	0	ID=cds-CCP46080.1;Parent=gene-Rv3261;Dbxref=EnsemblGenomes-Gn:Rv3261,EnsemblGenomes-Tr:CCP46080,GOA:P9WP81,InterPro:IPR002882,InterPro:IPR010115,NCBI_GP:CCP46080.1;Name=CCP46080.1;Note=Rv3261%2C (MTCY71.01)%2C len: 331 aa. Probable fbiA%2CF420 biosynthesis protein%2C equivalent to FBIA F420 biosynthesis protein fbiA from Mycobacterium bovis BCG (see citations below). Also equivalent%2C but shorter 46 aa%2C to Q9CCK1|ML0759 hypothetical protein from Mycobacterium leprae (379 aa)%2C FASTA scores: opt: 1855%2C E(): 3.9e-110%2C(79.3%25 identity in 333 aa overlap). Also similar to others e.g. Q9KZK9|SCE34.17 hypothetical 33.6 KDA protein from Streptomyces coelicolor (319 aa)%2C FASTA scores: opt: 1151%2CE(): 1.2e-65%2C (55.1%25 identity in 332 aa overlap)%3B O29345|AF0917 conserved hypothetical protein from Archaeoglobus fulgidus (296 aa)%2C FASTA scores: opt: 469%2CE(): 1.7e-22%2C (31.15%25 identity in 302 aa overlap)%3B Q58653|MJ1256 hypothetical protein from Methanococcus jannaschii (311 aa)%2C FASTA scores: opt: 436%2C E(): 2.2e-20%2C(27.35%25 identity in 274 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fbiA;locus_tag=Rv3261;product=Probable F420 biosynthesis protein FbiA;protein_id=CCP46080.1;transl_table=11
AL123456.3	EMBL	gene	3641535	3642881	.	+	.	ID=gene-Rv3262;Name=fbiB;gbkey=Gene;gene=fbiB;gene_biotype=protein_coding;locus_tag=Rv3262
AL123456.3	EMBL	CDS	3641535	3642881	.	+	0	ID=cds-CCP46081.1;Parent=gene-Rv3262;Dbxref=EnsemblGenomes-Gn:Rv3262,EnsemblGenomes-Tr:CCP46081,GOA:P9WP79,InterPro:IPR000415,InterPro:IPR002847,InterPro:IPR008225,InterPro:IPR019943,InterPro:IPR023661,InterPro:IPR029479,NCBI_GP:CCP46081.1;Name=CCP46081.1;Note=Rv3262%2C (MTCY71.02)%2C len: 448 aa. Probable fbiB%2CF420 biosynthesis protein%2C equivalent to FBIB F420 biosynthesis protein fbiB from Mycobacterium bovis BCG (see citations below). Also equivalent to Q9CCK2|ML0758 putative oxidoreductase from Mycobacterium leprae (457 aa)%2C FASTA scores: opt: 2411%2C E(): 3.5e-137%2C (82.25%25 identity in 445 aa overlap). Also similar to Q9KZK8|SCE34.18 putative oxidoreductase from Streptomyces coelicolor (443 aa)%2C FASTA scores: opt: 1180%2C E(): 2.2e-63%2C (51.75%25 identity in 433 aa overlap)%3B other oxidoreductases in C-terminus%3B and several hypothetical bacterial proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fbiB;locus_tag=Rv3262;product=Probable F420 biosynthesis protein FbiB;protein_id=CCP46081.1;transl_table=11
AL123456.3	EMBL	gene	3643177	3644838	.	+	.	ID=gene-Rv3263;Name=Rv3263;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3263
AL123456.3	EMBL	CDS	3643177	3644838	.	+	0	ID=cds-CCP46082.1;Parent=gene-Rv3263;Dbxref=EnsemblGenomes-Gn:Rv3263,EnsemblGenomes-Tr:CCP46082,GOA:P96868,InterPro:IPR002052,InterPro:IPR002296,InterPro:IPR029063,UniProtKB/TrEMBL:P96868,NCBI_GP:CCP46082.1;Name=CCP46082.1;Note=Rv3263%2C (MTCY71.03)%2C len: 553 aa. Probable DNA methylase%2C equivalent to Q9CCK4|ML0756 probable DNA methylase from Mycobacterium leprae (555 aa)%2C FASTA scores: opt: 2980%2C E(): 2.1e-184%2C (81.9%25 identity in 541 aa overlap). Also similar to others e.g. P25240|MT57_ECOLI|ECO57IM modification methylase from Escherichia coli (544 aa)%2C FASTA scores: opt: 595%2C E(): 1e-30%2C (30.35%25 identity in 507 aa overlap)%3B P25201|MTA1_ACICA|ACCIM modification methylase ACCI from Acinetobacter calcoaceticus (540 aa)%2C FASTA scores: opt: 366%2C E(): 5.7e-16%2C (23.35%25 identity in 467 aa overlap)%3B Q56752|M-ACCI ACCI methylase from Bergeyella zoohelcum (541 aa)%2C FASTA scores: opt: 365%2C E(): 6.6e-16%2C (22.95%25 identity in 466 aa overlap)%3B etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Alternative start site at aa 25.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00092;locus_tag=Rv3263;product=Probable DNA methylase (modification methylase) (methyltransferase);protein_id=CCP46082.1;transl_table=11
AL123456.3	EMBL	gene	3644898	3645977	.	-	.	ID=gene-Rv3264c;Name=manB;gbkey=Gene;gene=manB;gene_biotype=protein_coding;gene_synonym=hddC;locus_tag=Rv3264c
AL123456.3	EMBL	CDS	3644898	3645977	.	-	0	ID=cds-CCP46083.1;Parent=gene-Rv3264c;Dbxref=EnsemblGenomes-Gn:Rv3264c,EnsemblGenomes-Tr:CCP46083,GOA:L7N6A5,InterPro:IPR001451,InterPro:IPR005835,InterPro:IPR029044,UniProtKB/TrEMBL:L7N6A5,NCBI_GP:CCP46083.1;Name=CCP46083.1;Note=Rv3264c%2C (MTCY71.04c)%2C len: 359 aa. ManB (alternate gene name: hddC)%2C D-alpha-D-mannose-1-phosphate guanylyltransferase (see citations below)%2C equivalent to Q9CCK6|RMLA2|ML0753 putative sugar-phosphate nucleotidyl transferase from Mycobacterium leprae (358 aa)%2C FASTA scores: opt: 2075%2C E(): 2.7e-115%2C (86.9%25 identity in 359 aa overlap). Also similar to others e.g. Q9KZK6|SCE34.20c putative nucleotide phosphorylase from Streptomyces coelicolor (360 aa)%2C FASTA scores: opt: 1314%2C E(): 2.2e-70%2C(57.0%25 identity in 358 aa overlap)%3B Q9KZP4|SC1A8A.08 putative mannose-1-phosphate guanyltransferase from Streptomyces coelicolor (831 aa)%2C FASTA scores: opt: 699%2CE(): 8.6e-34%2C (34.45%25 identity in 354 aa overlap) (only similarity in N-terminus for this one)%3B P74589|SLL1496 mannose-1-phosphate guanyltransferase from Synechocystis sp. strain PCC 6803 (843 aa)%2C FASTA scores: opt: 692%2C E(): 2.3e-33%2C (35.1%25 identity in 342 aa overlap) (only similarity in N-terminus for this one too)%3B BAB59222|TVG0079558 mannose-1-phosphate guanyltransferase from Thermoplasma volcanium (359 aa)%2C FASTA scores: opt: 664%2C E(): 5.2e-32%2C (34.6%25 identity in 338 aa overlap)%3B Q9ZTW5|GMP GDP-mannose pyrophosphorylase from Solanum tuberosum (Potato) (361 aa)%2C FASTA scores: opt: 636%2C E(): 2.3e-30%2C (34.65%25 identity in 361 aa overlap)%3B etc. Belongs to family 2 of mannose-6-phosphate isomerases. Note that previously known as rmlA2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=manB;locus_tag=Rv3264c;product=D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (D-alpha-D-heptose-1-phosphate guanylyltransferase);protein_id=CCP46083.1;transl_table=11
AL123456.3	EMBL	gene	3645979	3646884	.	-	.	ID=gene-Rv3265c;Name=wbbL1;gbkey=Gene;gene=wbbL1;gene_biotype=protein_coding;gene_synonym=wbbL;locus_tag=Rv3265c
AL123456.3	EMBL	CDS	3645979	3646884	.	-	0	ID=cds-CCP46084.1;Parent=gene-Rv3265c;Dbxref=EnsemblGenomes-Gn:Rv3265c,EnsemblGenomes-Tr:CCP46084,GOA:P9WMY3,InterPro:IPR029044,NCBI_GP:CCP46084.1;Name=CCP46084.1;Note=Rv3265c%2C (MTCY71.05c)%2C len: 301 aa. wbbL1%2CdTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol a-3-L-rhamnosyl transferase (see citations below)%2C equivalent to Q9CCK7|WBBL|ML0752 putative dTDP-rhamnosyl transferase from Mycobacterium leprae (308 aa)%2C FASTA scores: opt: 1788%2CE(): 3e-104%2C (85.05%25 identity in 301 aa overlap)%3B and Q9RN50|WBBL|Q9RN49 (see note * below) dTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol%2Ca-3-L-rhamnosyl transferase from Mycobacterium smegmatis (296 aa)%2C FASTA scores: opt: 1494%2C E(): 6.1e-86%2C (72.35%25 identity in 293 aa overlap). Note that previously known as wbbL. [* Note: unpublished (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme%2C dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol%2C a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A.%2C Motichka K.%2C Jucker M.%2C Wu H.P.%2C Uhlic B.C.%2C Stern R.J.%2C Scherman M.S.%2C Vissa V.D.%2C Yan W.%2C Pan F.%2C Kimbrel S.%2C Kundu M.%2C McNeil M.].;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=wbbL1;locus_tag=Rv3265c;product=dTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol%2Ca-3-L-rhamnosyl transferase WbbL1 (alpha-L-rhamnose-(1->3)-alpha-D-GlcNAc(1->P)-P-decaprenyl);protein_id=CCP46084.1;transl_table=11
AL123456.3	EMBL	gene	3646895	3647809	.	-	.	ID=gene-Rv3266c;Name=rmlD;gbkey=Gene;gene=rmlD;gene_biotype=protein_coding;locus_tag=Rv3266c
AL123456.3	EMBL	CDS	3646895	3647809	.	-	0	ID=cds-CCP46085.1;Parent=gene-Rv3266c;Dbxref=EnsemblGenomes-Gn:Rv3266c,EnsemblGenomes-Tr:CCP46085,GOA:P9WH09,InterPro:IPR005913,InterPro:IPR016040,NCBI_GP:CCP46085.1;Name=CCP46085.1;Note=Rv3266c%2C (MTCY71.06c)%2C len: 304 aa. RmlD%2CdTDP-6-deoxy-L-lyxo-4-hexulose reductase (dTDP-rhamnose modification protein) (see citations below)%2C highly similar to Q9CCK8 putative dTDP-rhamnose modification protein from Mycobacterium leprae (311 aa)%2C FASTA scores%2C opt: 1440%2CE(): 1.1e-78%2C (74.7%25 identity in 312 aa overlap)%3B and similar to several dTDP-4-dehydrorhamnose reductase e.g. STRL_STRGR|P29781 from Streptomyces griseus (304 aa)%2C FASTA scores%2C opt: 788%2C E(): 0%2C (47.4%25 identity in 304 aa overlap).;gbkey=CDS;gene=rmlD;locus_tag=Rv3266c;product=dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-rhamnose modification protein) (dTDP-rhamnose biosynthesis protein) (dTDP-rhamnose synthase);protein_id=CCP46085.1;transl_table=11
AL123456.3	EMBL	gene	3647885	3649381	.	+	.	ID=gene-Rv3267;Name=Rv3267;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3267
AL123456.3	EMBL	CDS	3647885	3649381	.	+	0	ID=cds-CCP46086.1;Parent=gene-Rv3267;Dbxref=EnsemblGenomes-Gn:Rv3267,EnsemblGenomes-Tr:CCP46086,GOA:P96872,InterPro:IPR004474,InterPro:IPR027381,UniProtKB/TrEMBL:P96872,NCBI_GP:CCP46086.1;Name=CCP46086.1;Note=Rv3267%2C (MTCY71.07)%2C len: 498 aa. Conserved protein%2CCPSA-related protein%2C equivalent to Q9CCK9|ML0750 hypothetical protein from Mycobacterium leprae (489 aa)%2CFASTA scores: opt: 2523%2C E(): 5e-138%2C (78.9%25 identity in 498 aa overlap)%3B and Q50160|CPSA (hypothetical protein CPSA) from Mycobacterium leprae (516 aa)%2C FASTA scores: opt: 868%2C E(): 1.2e-42%2C (34.7%25 identity in 507 aa overlap). Also similar to O06347|CPSA|Rv3484|MTCY13E12.37 CPSA from Mycobacterium tuberculosis (512 aa)%2C FASTA scores: opt: 928%2C E(): 4.2e-46%2C (37.35%25 identity in 498 aa overlap)%3B and O53834|Rv0822c|MTV043.14c hypothetical 72.9 KDA protein from Mycobacterium tuberculosis (684 aa)%2C FASTA scores: opt: 434%2C E(): 1.5e-17%2C (30.9%25 identity in 541 aa overlap). Also similar to Q9KZK0|SCE34.26 conserved hypothetical protein from Streptomyces coelicolor (507 aa)%2C FASTA scores: opt: 437%2C E(): 8.1e-18%2C (28.55%25 identity in 469 aa overlap)%3B O68907 FRNA protein from Streptomyces roseofulvus (770 aa)%2C FASTA scores: opt: 388%2C E(): 7.6e-15%2C (32.6%25 identity in 267 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3267;product=Conserved protein (CPSA-related protein);protein_id=CCP46086.1;transl_table=11
AL123456.3	EMBL	gene	3649420	3650109	.	+	.	ID=gene-Rv3268;Name=Rv3268;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3268
AL123456.3	EMBL	CDS	3649420	3650109	.	+	0	ID=cds-CCP46087.1;Parent=gene-Rv3268;Dbxref=EnsemblGenomes-Gn:Rv3268,EnsemblGenomes-Tr:CCP46087,InterPro:IPR017523,UniProtKB/TrEMBL:P96873,NCBI_GP:CCP46087.1;Name=CCP46087.1;Note=Rv3268%2C (MTCY71.08)%2C len: 229 aa. Conserved hypothetical protein%2C similar to Q9KZK4|SCE34.22 hypothetical 27.1 KDA protein from Streptomyces coelicolor (263 aa)%2C FASTA scores: opt: 442%2C E(): 5.9e-20%2C (40.1%25 identity in 242 aa overlap). Also weak similarity to N-terminal part (approximately 1530 to 1740 residues) of O07944|SNBDE pristinamycin I synthase 3 and 4 from Streptomyces pristinaespiralis (4848 aa)%2C FASTA scores: opt: 159%2C E(): 0.11%2C (30.35%25 identity in 224 aa overlap).;gbkey=CDS;locus_tag=Rv3268;product=Conserved hypothetical protein;protein_id=CCP46087.1;transl_table=11
AL123456.3	EMBL	gene	3650234	3650515	.	+	.	ID=gene-Rv3269;Name=Rv3269;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3269
AL123456.3	EMBL	CDS	3650234	3650515	.	+	0	ID=cds-CCP46088.1;Parent=gene-Rv3269;Dbxref=EnsemblGenomes-Gn:Rv3269,EnsemblGenomes-Tr:CCP46088,GOA:P96874,InterPro:IPR009963,UniProtKB/TrEMBL:P96874,NCBI_GP:CCP46088.1;Name=CCP46088.1;Note=Rv3269%2C (MTCY71.09)%2C len: 93 aa. Conserved protein%2Csimilar to many Mycobacterium proteins and chaperonins/heat shock proteins e.g. Q9CCL0|ML0748 hypothetical protein from Mycobacterium leprae (92 aa)%2C FASTA scores: opt: 427%2C E(): 6.8e-21%2C (73.65%25 identity in 91 aa overlap)%3B Q10865|Rv1993c|MT2049|MTCY39.26c hypothetical protein from Mycobacterium tuberculosis (90 aa)%2C FASTA scores: opt: 313%2CE(): 1.2e-13%2C (60.7%25 identity in 84 aa overlap)%3B P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c (98 aa)%2C FASTA scores: opt: 294%2C E(): 2.2e-12%2C (55.1%25 identity in 98 aa overlap)%3B Q50827|MOPA|GROEL|CH60_MYCVA chaperonin (protein CPN60) from Mycobacterium vaccae (120 aa)%2C FASTA scores: opt: 107%2C E(): 2.1%2C (39.5%25 identity in 81 aa overlap)%3B Q9AEB3|HSP65 heat shock protein (fragment) from Mycobacterium gadium (122 aa)%2C FASTA scores: opt: 102%2C E(): 4.4%2C (38.25%25 identity in 81 aa overlap)%3B Q49374|CH60_MYCGN|MOPA|GROEL chaperonin (protein CPN60) from Mycobacterium genavense (120 aa)%2C FASTA scores: opt: 99%2C E(): 6.8%2C (40.25%25 identity in 82 aa overlap)%3B etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3269;product=Conserved protein;protein_id=CCP46088.1;transl_table=11
AL123456.3	EMBL	gene	3650526	3652682	.	+	.	ID=gene-Rv3270;Name=ctpC;gbkey=Gene;gene=ctpC;gene_biotype=protein_coding;locus_tag=Rv3270
AL123456.3	EMBL	CDS	3650526	3652682	.	+	0	ID=cds-CCP46089.1;Parent=gene-Rv3270;Dbxref=EnsemblGenomes-Gn:Rv3270,EnsemblGenomes-Tr:CCP46089,GOA:P9WPT5,InterPro:IPR001757,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,InterPro:IPR027256,NCBI_GP:CCP46089.1;Name=CCP46089.1;Note=Rv3270%2C (MT3370%2C MTCY71.10)%2C len: 718 aa. Probable ctpC%2C metal cation-transport ATPase P-type%2C integral membrane protein%2C equivalent to Q9CCL1|CTPC|ML0747 putative cation transport ATPase from Mycobacterium leprae (725 aa)%2CFASTA scores: opt: 3908%2C E(): 0%2C (85.95%25 identity in 713 aa overlap). Also similar to O66027|MTAA metal transporting ATPase MTA72 from Mycobacterium tuberculosis (680 aa)%2CFASTA scores: opt: 3756%2C E(): 5.5e-213%2C (91.45%25 identity in 679 aa overlap)%3B and to other ATPases e.g. Q9ZHC7|SILP_SALTY putative cation transporting P-type ATPase from Salmonella typhimurium (824 aa)%2C FASTA scores: opt: 1145%2C E(): 1.3e-59%2C (36.55%25 identity in 643 aa overlap)%3B Q9HX93|PA3920 probable metal transporting P-type ATPase from Pseudomonas aeruginosa (792 aa)%2C FASTA scores: opt: 1140%2C E(): 2.4e-59%2C (35.95%25 identity in 745 aa overlap)%3B etc. Contains PS00154 E1-E2 ATPases phosphorylation site. Belongs to the cation transport ATPases family (E1-E2 ATPases)%2C subfamily IB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ctpC;inference=protein motif:PROSITE:PS00154;locus_tag=Rv3270;product=Probable metal cation-transporting P-type ATPase C CtpC;protein_id=CCP46089.1;transl_table=11
AL123456.3	EMBL	gene	3652679	3653347	.	-	.	ID=gene-Rv3271c;Name=Rv3271c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3271c
AL123456.3	EMBL	CDS	3652679	3653347	.	-	0	ID=cds-CCP46090.1;Parent=gene-Rv3271c;Dbxref=EnsemblGenomes-Gn:Rv3271c,EnsemblGenomes-Tr:CCP46090,GOA:P96876,InterPro:IPR002524,InterPro:IPR026765,InterPro:IPR027469,UniProtKB/TrEMBL:P96876,NCBI_GP:CCP46090.1;Name=CCP46090.1;Note=Rv3271c%2C (MTCY71.11c)%2C len: 222 aa. Probable conserved integral membrane protein%2C similar to others e.g. Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa)%2CFASTA scores: opt: 360%2C E(): 4.7e-16%2C (33.85%25 identity in 195 aa overlap)%3B Q9X897|SCE2.02c from Streptomyces coelicolor (234 aa)%2C FASTA scores: opt: 357%2C E(): 7.3e-16%2C(33.85%25 identity in 195 aa overlap)%3B Q9D0E0 2610024A01RIK protein from Mus musculus (Mouse) (288 aa)%2C FASTA scores: opt: 191%2C E(): 3.7e-05%2C (23.65%25 identity in 207 aa overlap).;gbkey=CDS;locus_tag=Rv3271c;product=Probable conserved integral membrane protein;protein_id=CCP46090.1;transl_table=11
AL123456.3	EMBL	gene	3653448	3654632	.	+	.	ID=gene-Rv3272;Name=Rv3272;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3272
AL123456.3	EMBL	CDS	3653448	3654632	.	+	0	ID=cds-CCP46091.1;Parent=gene-Rv3272;Dbxref=EnsemblGenomes-Gn:Rv3272,EnsemblGenomes-Tr:CCP46091,GOA:P96877,InterPro:IPR003673,InterPro:IPR023606,UniProtKB/TrEMBL:P96877,NCBI_GP:CCP46091.1;Name=CCP46091.1;Note=Rv3272%2C (MTCY71.12)%2C len: 394 aa. Conserved hypothetical protein%2C similar to various proteins e.g. Q9I672|PA0446 hypothetical protein from Pseudomonas aeruginosa (407 aa)%2C FASTA scores: opt: 643%2C E(): 6.8e-32%2C(33.15%25 identity in 389 aa overlap)%3B Q9RJU8|SCF41.21 putative racemase from Streptomyces coelicolor (403 aa)%2CFASTA scores: opt: 541%2C E(): 1.1e-25%2C (31.95%25 identity in 385 aa overlap)%3B O87838|SC8A6.04c putative transferase from Streptomyces coelicolor (410 aa)%2C FASTA scores: opt: 539%2CE(): 1.5e-25%2C (29.95%25 identity in 395 aa overlap)%3B Q9I563|PA0882 from Pseudomonas aeruginosa (400 aa)%2C FASTA scores: opt: 530%2C E(): 5.2e-25%2C (28.8%25 identity in 396 aa overlap)%3B BAB60328|TVG1215416 L-carnitine dehydratase from Thermoplasma volcanium (399 aa)%2C FASTA scores: opt: 529%2CE(): 6e-25%2C (32.9%25 identity in 383 aa overlap)%3B etc. C-terminus is similar to Q49678|U00012_27|B1308_C3_195 from Mycobacterium leprae (130 aa) (60.0%25 identity in 115 aa overlap). Also partially similar to MTCY359_7 from M. tuberculosis (778 aa) (29.9%25 identity in 388 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3272;product=Conserved hypothetical protein;protein_id=CCP46091.1;transl_table=11
AL123456.3	EMBL	gene	3654637	3656931	.	+	.	ID=gene-Rv3273;Name=Rv3273;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3273
AL123456.3	EMBL	CDS	3654637	3656931	.	+	0	ID=cds-CCP46092.1;Parent=gene-Rv3273;Dbxref=EnsemblGenomes-Gn:Rv3273,EnsemblGenomes-Tr:CCP46092,GOA:P96878,InterPro:IPR001765,InterPro:IPR011547,InterPro:IPR015892,UniProtKB/TrEMBL:P96878,NCBI_GP:CCP46092.1;Name=CCP46092.1;Note=Rv3273%2C (MTCY71.13)%2C len: 764 aa. Probable transmembrane protein (N-terminal part is hydrophobic) with probable carbonic anhydrase activity (in C-terminal part). Possibly involved in transport of sulfate. Equivalent to Q9CBA3|ML2279 putative transmembrane transport protein from Mycobacterium leprae (496 aa)%2C FASTA scores: opt: 1637%2CE(): 1.8e-89%2C (59.15%25 identity in 487 aa overlap). Similar to various proteins (principally sulfate transporters) e.g. Q9X927|SCH5.25 putative integral membrane protein from Streptomyces coelicolor (830 aa)%2C FASTA scores: opt: 1325%2CE(): 8e-71%2C (40.85%25 identity in 788 aa overlap)%3B Q9I729|PA0103 probable sulfate transporter from Pseudomonas aeruginosa (523 aa)%2C FASTA scores: opt: 1015%2C E(): 1.3e-52%2C(39.95%25 identity in 488 aa overlap)%3B Q9KN88|VCA0077 sulfate permease family protein from Vibrio cholerae (553 aa)%2CFASTA scores: opt: 629%2C E(): 9.6e-30%2C (30.95%25 identity in 423 aa overlap)%3B etc. C-terminal part (aa 550-764) shows similarity to carbonic anhydrase e.g. P27134|CYNT_SYNP7 carbonic anhydrase (272 aa)%2C FASTA scores: opt: 350%2C E(): 8.1e-15%2C (33.8%25 identity in 201 aa overlap). Contains PS00704 Prokaryotic-type carbonic anhydrases signature 1. Seems to belong to the SulP family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00704;locus_tag=Rv3273;product=Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase);protein_id=CCP46092.1;transl_table=11
AL123456.3	EMBL	gene	3656920	3658089	.	-	.	ID=gene-Rv3274c;Name=fadE25;gbkey=Gene;gene=fadE25;gene_biotype=protein_coding;locus_tag=Rv3274c
AL123456.3	EMBL	CDS	3656920	3658089	.	-	0	ID=cds-CCP46093.1;Parent=gene-Rv3274c;Dbxref=EnsemblGenomes-Gn:Rv3274c,EnsemblGenomes-Tr:CCP46093,GOA:P9WQG1,InterPro:IPR006089,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,NCBI_GP:CCP46093.1;Name=CCP46093.1;Note=Rv3274c%2C (MTCY71.14c)%2C len: 389 aa. Probable fadE25%2CAcyl-CoA Dehydrogenase%2C equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 probable acyl-CoA dehydrogenase FADE25 from Mycobacterium leprae (389 aa)%2C FASTA scores: opt: 2394%2C E(): 3.8e-143%2C (92.05%25 identity in 389 aa overlap). Also similar to many e.g. Q9RIQ5|fade fatty acid acyl-CoA dehydrogenase from Streptomyces lividans (385 aa)%2C FASTA scores: opt: 1692%2CE(): 4.9e-99%2C (67.35%25 identity in 383 aa overlap)%3B P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa)%2CFASTA scores: opt: 1212%2C E(): 7.2e-69%2C (51.85%25 identity in 376 aa overlap)%3B Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa)%2C FASTA scores: opt: 1209%2C E(): 1.1e-68%2C(51.7%25 identity in 377 aa overlap)%3B P52042|ACDS_CLOAB|BCD from Clostridium acetobutylicum (379 aa)%2C FASTA scores: opt: 1056%2C E(): 4.6e-59%2C (44.6%25 identity in 379 aa overlap)%3B etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1%2C PS00073 Acyl-CoA dehydrogenases signature 2. Belongs to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE25;inference=protein motif:PROSITE:PS00073;locus_tag=Rv3274c;product=Probable acyl-CoA dehydrogenase FadE25;protein_id=CCP46093.1;transl_table=11
AL123456.3	EMBL	gene	3658114	3658638	.	-	.	ID=gene-Rv3275c;Name=purE;gbkey=Gene;gene=purE;gene_biotype=protein_coding;locus_tag=Rv3275c
AL123456.3	EMBL	CDS	3658114	3658638	.	-	0	ID=cds-CCP46094.1;Parent=gene-Rv3275c;Dbxref=EnsemblGenomes-Gn:Rv3275c,EnsemblGenomes-Tr:CCP46094,GOA:P9WHM1,InterPro:IPR000031,InterPro:IPR024694,PDB:3LP6,NCBI_GP:CCP46094.1;Name=CCP46094.1;Note=Rv3275c%2C (MTCY71.15c%2C PUR6)%2C len: 174 aa. Probable purE%2C phosphoribosylaminoimidazole carboxylase catalytic subunit%2C equivalent to P46702|PUR6_MYCLE|pure|ML0736|B1308_F3_98 from Mycobacterium leprae (171 aa)%2C FASTA scores: opt: 878%2C E(): 1.5e-43%2C (81.55%25 identity in 168 aa overlap). Also similar to others e.g. Q9AXD0|AIRC from Nicotiana tabacum (Common tobacco) (623 aa)%2C FASTA scores: opt: 712%2C E(): 1.4e-33%2C(69.35%25 identity in 160 aa overlap) (similarity in C-terminal part for this one)%3B Q44679|PUR6_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (177 aa)%2C FASTA scores: opt: 651%2C E(): 1.5e-30%2C (68.25%25 identity in 148 aa overlap)%3B Q55498|PUR6_SYNY3|pure|SLL0901 from Synechocystis sp. strain PCC 6803 (176 aa)%2C FASTA scores: opt: 639%2C E(): 7.1e-30%2C (60.5%25 identity in 167 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purE;locus_tag=Rv3275c;product=Probable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AIRC);protein_id=CCP46094.1;transl_table=11
AL123456.3	EMBL	gene	3658635	3659924	.	-	.	ID=gene-Rv3276c;Name=purK;gbkey=Gene;gene=purK;gene_biotype=protein_coding;locus_tag=Rv3276c
AL123456.3	EMBL	CDS	3658635	3659924	.	-	0	ID=cds-CCP46095.1;Parent=gene-Rv3276c;Dbxref=EnsemblGenomes-Gn:Rv3276c,EnsemblGenomes-Tr:CCP46095,GOA:P9WHL9,InterPro:IPR003135,InterPro:IPR005875,InterPro:IPR011054,InterPro:IPR011761,InterPro:IPR013816,InterPro:IPR016185,NCBI_GP:CCP46095.1;Name=CCP46095.1;Note=Rv3276c%2C (MTCY71.16c)%2C len: 429 aa. Probable purK%2Cphosphoribosylaminoimidazole carboxylase ATPase subunit %2Cequivalent to P46701|PURK_MYCLE|ML0735|B1308_F1_32 phosphoribosylaminoimidazole carboxylase ATPase subunit from Mycobacterium leprae (439 aa)%2C FASTA scores: opt: 2168%2C E(): 2.3e-123%2C (76.15%25 identity in 444 aa overlap). Also similar to others e.g. Q44678|PURK_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (413 aa)%2C FASTA scores: opt: 1179%2C E(): 9.1e-64%2C (48.35%25 identity in 389 aa overlap)%3B Q9KZ85|PURK from Streptomyces coelicolor (368 aa)%2C FASTA scores: opt: 1150%2C E(): 4.7e-62%2C(55.35%25 identity in 345 aa overlap)%3B Q54975|PURK_SYNP7 from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (395 aa)%2C FASTA scores: opt: 772%2C E(): 3e-39%2C (38.1%25 identity in 383 aa overlap)%3B etc. Belongs to the PurK / PurT family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=purK;locus_tag=Rv3276c;product=Probable phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AIRC);protein_id=CCP46095.1;transl_table=11
AL123456.3	EMBL	repeat_region	3658658	3658715	.	-	.	ID=id-Rv3276c;Note=58 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region;gene=purK;locus_tag=Rv3276c
AL123456.3	EMBL	gene	3659878	3660696	.	+	.	ID=gene-Rv3277;Name=Rv3277;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3277
AL123456.3	EMBL	CDS	3659878	3660696	.	+	0	ID=cds-CCP46096.1;Parent=gene-Rv3277;Dbxref=EnsemblGenomes-Gn:Rv3277,EnsemblGenomes-Tr:CCP46096,GOA:P96882,InterPro:IPR007267,UniProtKB/TrEMBL:P96882,NCBI_GP:CCP46096.1;Name=CCP46096.1;Note=Rv3277%2C (MTCY71.17)%2C len: 272 aa. Probable conserved transmembrane protein%2C equivalent%2C but longer 49 aa%2C to Q49673|B1308_C1_121|ML0734 putative membrane protein from Mycobacterium leprae (228 aa)%2C FASTA scores: opt: 1266%2CE(): 6.1e-78%2C (84.2%25 identity in 228 aa overlap). Also similar to various proteins (principally unknowns) e.g. Q9KZ84|SCE25.02 putative integral membrane protein from Streptomyces coelicolor (190 aa)%2C FASTA scores: opt: 197%2CE(): 3.6e-06%2C (32.0%25 identity in 150 aa overlap)%3B BAB50058|MLL3086 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (136 aa)%2C FASTA scores: opt: 176%2C E(): 6.9e-05%2C (34.7%25 identity in 147 aa overlap)%3B O29640|AF0615 hypothetical protein from Archaeoglobus fulgidus (129 aa)%2CFASTA scores: opt: 120%2C E(): 0.38%2C (23.35%25 identity in 120 aa overlap)%3B Q9KJU8|GTCA teichoic acid glycosylation protein from Listeria innocua (145 aa)%2C FASTA scores: opt: 117%2C E(): 0.67%2C (23.85%25 identity in 151 aa overlap)%3B etc. Equivalent to AAK47718 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 16 aa. Contains PS00044 Bacterial regulatory proteins%2C lysR family signature. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv3277;product=Probable conserved transmembrane protein;protein_id=CCP46096.1;transl_table=11
AL123456.3	EMBL	gene	3660651	3661169	.	-	.	ID=gene-Rv3278c;Name=Rv3278c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3278c
AL123456.3	EMBL	CDS	3660651	3661169	.	-	0	ID=cds-CCP46097.1;Parent=gene-Rv3278c;Dbxref=EnsemblGenomes-Gn:Rv3278c,EnsemblGenomes-Tr:CCP46097,GOA:P96883,InterPro:IPR005182,UniProtKB/TrEMBL:P96883,NCBI_GP:CCP46097.1;Name=CCP46097.1;Note=Rv3278c%2C (MTCY71.18c)%2C len: 172 aa. Probable conserved transmembrane protein%2C equivalent to Q9CCL2|ML0733 putative membrane protein from Mycobacterium leprae (172 aa)%2C FASTA scores: opt: 1024%2C E(): 6e-61%2C(83.15%25 identity in 172 aa overlap)%3B and Q49672|B1308_F2_67 hypothetical protein from Mycobacterium leprae (181 aa)%2CFASTA scores: opt: 1024%2C E(): 6.3e-61%2C (83.15%25 identity in 172 aa overlap) (this is certainly the same putative protein but with N-terminus longer). Also some similarity to other hypothetical proteins (generally membrane proteins) e.g. O26822|MTH726 hypothetical protein from Methanobacterium thermoautotrophicum (204 aa)%2C FASTA scores: opt: 147%2C E(): 0.0079%2C (24.6%25 identity in 187 aa overlap)%3B Q9X8H4|SCE9.01 hypothetical 47.7 KDA protein (fragment) from Streptomyces coelicolor (436 aa)%2C FASTA scores: opt: 151%2C E(): 0.0079%2C (28.1%25 identity in 153 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3278c;product=Probable conserved transmembrane protein;protein_id=CCP46097.1;transl_table=11
AL123456.3	EMBL	gene	3661212	3662012	.	-	.	ID=gene-Rv3279c;Name=birA;gbkey=Gene;gene=birA;gene_biotype=protein_coding;locus_tag=Rv3279c
AL123456.3	EMBL	CDS	3661212	3662012	.	-	0	ID=cds-CCP46098.1;Parent=gene-Rv3279c;Dbxref=EnsemblGenomes-Gn:Rv3279c,EnsemblGenomes-Tr:CCP46098,GOA:I6YFP0,InterPro:IPR003142,InterPro:IPR004143,InterPro:IPR004408,PDB:4OP0,UniProtKB/TrEMBL:I6YFP0,NCBI_GP:CCP46098.1;Name=CCP46098.1;Note=Rv3279c%2C (MTCY71.19c)%2C len: 266 aa. Possible birA%2Cbifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase%2C equivalent to Q9CCL3|BIRA|ML0732 biotin APO-protein ligase from Mycobacterium leprae (274 aa)%2C FASTA scores: opt: 1189%2CE(): 2.3e-66%2C (71.2%25 identity in 271 aa overlap). But as it lacks a BirA h-t-h domain at N-terminus%2C may simply be biotin apo-protein ligase. Also similar to others e.g. Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312 aa)%2CFASTA scores: opt: 347%2C E(): 2.7e-14%2C (32.95%25 identity in 270 aa overlap)%3B Q9HWC0|BIRA|PA4280 from Pseudomonas aeruginosa (312 aa)%2C FASTA scores: opt: 335%2C E(): 1.5e-13%2C(34.2%25 identity in 272 aa overlap)%3B Q9A6Z0|CC1936 from Caulobacter crescentus (250 aa)%2C FASTA scores: opt: 332%2CE(): 1.9e-13%2C (33.6%25 identity in 238 aa overlap)%3B P06709|BIRA_ECOLI (321 aa)%2C FASTA scores: opt: 314%2C E(): 3.1e-12%2C (34.15%25 identity in 249 aa overlap)%3B etc. Similar with other bacterial BIRA and with eukaryotic biotin APO-protein ligase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=birA;locus_tag=Rv3279c;product=Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligase);protein_id=CCP46098.1;transl_table=11
AL123456.3	EMBL	gene	3662062	3663708	.	+	.	ID=gene-Rv3280;Name=accD5;gbkey=Gene;gene=accD5;gene_biotype=protein_coding;locus_tag=Rv3280
AL123456.3	EMBL	CDS	3662062	3663708	.	+	0	ID=cds-CCP46099.1;Parent=gene-Rv3280;Dbxref=EnsemblGenomes-Gn:Rv3280,EnsemblGenomes-Tr:CCP46099,GOA:P9WQH7,InterPro:IPR000022,InterPro:IPR011762,InterPro:IPR011763,InterPro:IPR029045,PDB:2A7S,PDB:2BZR,NCBI_GP:CCP46099.1;Name=CCP46099.1;Note=Rv3280%2C (MTCY71.20%2C pccB)%2C len: 548 aa. Probable accD5%2C propionyl-CoA carboxylase beta chain 5%2C equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 probable propionyl-CoA carboxylase beta chain 5 from Mycobacterium leprae (549 aa)%2C FASTA scores: opt: 3241%2C E(): 4e-192%2C(88.7%25 identity in 549 aa overlap). Also similar to many e.g. O87201|DTSR2 DTSR2 protein involved in glutamate production from Corynebacterium glutamicum (Brevibacterium flavum) (537 aa)%2C FASTA scores: opt: 2604%2C E(): 6.9e-153%2C(74.1%25 identity in 529 aa overlap) (see Kimura et al.%2C1996)%3B P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa)%2C FASTA scores: opt: 2466%2C E(): 2.2e-144%2C (70.2%25 identity in 530 aa overlap)%3B O88155|DTSR1 DTSR1 protein from Corynebacterium glutamicum (Brevibacterium flavum) (543 aa)%2C FASTA scores: opt: 2375%2CE(): 8.8e-139%2C (67.1%25 identity in 529 aa overlap%3B Q9X4K7|PCCB from Streptomyces coelicolor (530 aa)%2C FASTA scores: opt: 2360%2C E(): 7.3e-138%2C (67.9%25 identity in 533 aa overlap)%3B O24789|mxpccb from Myxococcus xanthus (524 aa)%2CFASTA scores: opt: 1868%2C E(): 1.5e-107%2C (56.85%25 identity in 524 aa overlap)%3B etc. Also similar with methylmalonyl-CoA decarboxylases e.g. O59018|PH1287 from Pyrococcus horikoshii (522 aa)%2C FASTA scores: opt: 1841%2C E(): 6.7e-106%2C (54.15%25 identity in 528 aa overlap). Also similarity with MTCY427.28 (43.8%25 identity in 434 aa overlap). Belongs to the ACCD/PCCB family. AccA3 (Rv3285)%2CAccD5 (Rv3280)%2C AccD4 (Rv3799)%2C and AccE5 (Rv3281) form a biotin-dependent acyl-CoA carboxylase in M. tuberculosis H37Rv (See Oh et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accD5;locus_tag=Rv3280;product=Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase);protein_id=CCP46099.1;transl_table=11
AL123456.3	EMBL	gene	3663689	3664222	.	+	.	ID=gene-Rv3281;Name=accE5;gbkey=Gene;gene=accE5;gene_biotype=protein_coding;locus_tag=Rv3281
AL123456.3	EMBL	CDS	3663689	3664222	.	+	0	ID=cds-CCP46100.1;Parent=gene-Rv3281;Dbxref=EnsemblGenomes-Gn:Rv3281,EnsemblGenomes-Tr:CCP46100,GOA:P96886,UniProtKB/TrEMBL:P96886,NCBI_GP:CCP46100.1;Name=CCP46100.1;Note=Rv3281%2C (MTCY71.21)%2C len: 177 aa. Probable accE5%2Cbifunctional acetyl-/propionyl-coenzyme A carboxylase%2Cepsilon chain%2C equivalent (but longer 14 aa and with a gap between aa 82-102) to AAK47723|MT3380 from Mycobacterium tuberculosis strain CDC1551 (142 aa)%2C FASTA scores: opt: 830%2C E(): 3.1e-40%2C (86.5%25 identity in 163 aa overlap). C-terminus highly similar to Q49671|B1308_C3_211|ML0730 from Mycobacterium leprae (84 aa)%2C FASTA scores: opt: 393%2CE(): 7.6e-16%2C (68.95%25 identity in 87 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). AccA3 (Rv3285)%2C AccD5 (Rv3280)%2CAccD4 (Rv3799)%2C and AccE5 (Rv3281) form a biotin-dependent acyl-CoA carboxylase in M. tuberculosis H37Rv (See Oh et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accE5;locus_tag=Rv3281;product=Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (epsilon chain) AccE5;protein_id=CCP46100.1;transl_table=11
AL123456.3	EMBL	gene	3664219	3664887	.	+	.	ID=gene-Rv3282;Name=Rv3282;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3282
AL123456.3	EMBL	CDS	3664219	3664887	.	+	0	ID=cds-CCP46101.1;Parent=gene-Rv3282;Dbxref=EnsemblGenomes-Gn:Rv3282,EnsemblGenomes-Tr:CCP46101,GOA:P9WK27,InterPro:IPR003697,InterPro:IPR029001,NCBI_GP:CCP46101.1;Name=CCP46101.1;Note=Rv3282%2C (MTCY71.22)%2C len: 222 aa. Conserved hypothetical protein%2C equivalent to Q49670|ML0729 1308R (hypothetical protein ML0729) from Mycobacterium leprae (213 aa)%2C FASTA scores: opt: 945%2C E(): 5.5e-54%2C (68.55%25 identity in 213 aa overlap). Also similar to Q9EWV6|2SCK31.18 conserved hypothetical protein from Streptomyces coelicolor (206 aa)%2C FASTA scores: opt: 459%2CE(): 1.3e-22%2C (47.35%25 identity in 209 aa overlap)%3B P74331|MAF or SLL0905 MAF protein from Synechocystis sp. strain PCC 6803 (195 aa)%2C FASTA scores: opt: 401%2C E(): 6.9e-19%2C (43.0%25 identity in 207 aa overlap)%3B and shows weak similarity with various proteins e.g. Q9BUL6 acetylserotonin O-methyltransferase-like from Homo sapiens (Human) (621 aa)%2C FASTA scores: opt: 282%2C E(): 8.9e-11%2C(31.6%25 identity in 193 aa overlap)%3B O95671|ASMTL ASMTL protein from Homo sapiens (Human) (629 aa)%2C FASTA scores: opt: 282%2C E(): 9e-11%2C (31.6%25 identity in 193 aa overlap)%3B BAB51136|MLR4491 MAF protein from Rhizobium loti (Mesorhizobium loti) (199 aa)%2C FASTA scores: opt: 269%2C E(): 2.3e-10%2C (29.3%25 identity in 198 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3282;product=Conserved hypothetical protein;protein_id=CCP46101.1;transl_table=11
AL123456.3	EMBL	gene	3664928	3665821	.	+	.	ID=gene-Rv3283;Name=sseA;gbkey=Gene;gene=sseA;gene_biotype=protein_coding;locus_tag=Rv3283
AL123456.3	EMBL	CDS	3664928	3665821	.	+	0	ID=cds-CCP46102.1;Parent=gene-Rv3283;Dbxref=EnsemblGenomes-Gn:Rv3283,EnsemblGenomes-Tr:CCP46102,GOA:P9WHF7,InterPro:IPR001307,InterPro:IPR001763,PDB:3HZU,NCBI_GP:CCP46102.1;Name=CCP46102.1;Note=Rv3283%2C (MTCY71.23)%2C len: 297 aa. Probable sseA%2Cthiosulfate sulfurtransferase%2C equivalent P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 putative thiosulfate sulfurtransferase SSEA from Mycobacterium leprae (296 aa)%2C FASTA scores: opt: 1742%2C E(): 5.5e-108%2C(83.45%25 identity in 296 aa overlap). Also highly similar to others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans (286 aa)%2C FASTA scores: opt: 1057%2C E(): 1.2e-62%2C (53.86%25 identity in 273 aa overlap)%3B P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa)%2C FASTA scores: opt: 1006%2C E(): 2.7e-59%2C (51.25%25 identity in 277 aa overlap)%3B P71121|THTR_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (225 aa)%2C FASTA scores: opt: 897%2C E(): 3.6e-52%2C (59.05%25 identity in 215 aa overlap)%3B etc. Also highly similar to O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c|M T0837|MTV043.07c|THTR_MYCTU putative thiosulfate sulfurtransferase from Mycobacterium tuberculosis (277 aa)%2C FASTA scores: opt: 955%2C E(): 6.3e-56%2C (50.2%25 identity in 271 aa overlap)%3B and Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 putative thiosulfate sulfurtransferase from Mycobacterium leprae (277 aa)%2C FASTA scores: opt: 931%2C E(): 2.5e-54%2C (48.9%25 identity in 276 aa overlap). Shows some similarity to MTCY339.19c (30.3%25 identity in 254 aa overlap). Contains PS00683 Rhodanese C-terminal signature. Belongs to the rhodanese family. Thought to be differentially expressed within host cells (see Triccas et al.%2C 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sseA;inference=protein motif:PROSITE:PS00683;locus_tag=Rv3283;product=Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase);protein_id=CCP46102.1;transl_table=11
AL123456.3	EMBL	gene	3665818	3666249	.	+	.	ID=gene-Rv3284;Name=Rv3284;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3284
AL123456.3	EMBL	CDS	3665818	3666249	.	+	0	ID=cds-CCP46103.1;Parent=gene-Rv3284;Dbxref=EnsemblGenomes-Gn:Rv3284,EnsemblGenomes-Tr:CCP46103,InterPro:IPR003808,NCBI_GP:CCP46103.1;Name=CCP46103.1;Note=Rv3284%2C (MTCY71.24%2C unknown)%2C len: 143 aa. Conserved hypothetical protein%2C with similarity to other bacterial hypothetical proteins e.g. Q9RXU0|DR0216 from Deinococcus radiodurans (147 aa)%2C FASTA scores: opt: 425%2C E(): 9.1e-21%2C(46.55%25 identity in 146 aa overlap)%3B BAB37094|ECS3671 from Escherichia coli strain O157:H7 (147 aa)%2C FASTA scores: opt: 187%2C E(): 2.2e-05%2C (29.5%25 identity in 139 aa overlap)%3B AAG57925|YGDK from Escherichia coli strain O157:H7 EDL933 (147 aa)%2C FASTA scores: opt: 187%2C E(): 2.2e-05%2C (32.05%25 identity in 139 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3284;product=Conserved hypothetical protein;protein_id=CCP46103.1;transl_table=11
AL123456.3	EMBL	gene	3666357	3668159	.	+	.	ID=gene-Rv3285;Name=accA3;gbkey=Gene;gene=accA3;gene_biotype=protein_coding;locus_tag=Rv3285
AL123456.3	EMBL	CDS	3666357	3668159	.	+	0	ID=cds-CCP46104.1;Parent=gene-Rv3285;Dbxref=EnsemblGenomes-Gn:Rv3285,EnsemblGenomes-Tr:CCP46104,GOA:P96890,InterPro:IPR000089,InterPro:IPR001882,InterPro:IPR005479,InterPro:IPR005481,InterPro:IPR005482,InterPro:IPR011053,InterPro:IPR011054,InterPro:IPR011761,InterPro:IPR011764,InterPro:IPR013815,InterPro:IPR013816,InterPro:IPR016185,UniProtKB/TrEMBL:P96890,NCBI_GP:CCP46104.1;Name=CCP46104.1;Note=Rv3285%2C (MTCY71.25)%2C len: 600 aa. Probable accA3%2Cbifunctional protein acetyl-/propionyl-coenzyme A carboxylase%2C alpha chain (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 acetyl-/propionyl-coenzyme A carboxylase alpha chain from Mycobacterium leprae (598 aa)%2C FASTA scores: opt: 3510%2CE(): 1.1e-196%2C (89.3%25 identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC acyl coenzyme A carboxylase from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa)%2C FASTA scores: opt: 2776%2CE(): 5.6e-154%2C (71.95%25 identity in 592 aa overlap)%3B Q54119|BCPA2 biotin carboxylase and biotin carboxyl carrier protein from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa)%2C FASTA scores: opt: 2723%2C E(): 6.7e-151%2C (70.5%25 identity in 590 aa overlap)%3B Q54105|BCPA biotin carboxylase and biotin carboxyl carrier protein from Saccharopolyspora erythraea (Streptomyces erythraeus) (597 aa)%2C FASTA scores: opt: 2721%2C E(): 8.9e-151%2C (70.05%25 identity in 594 aa overlap)%3B Q9EWV4|2SCK31.20 putative acyl-CoA carboxylase complex a subunit from Streptomyces coelicolor (590 aa)%2C FASTA scores: opt: 2626%2C E(): 2.9e-145%2C (68.25%25 identity in 595 aa overlap)%3B etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2%2C PS00188 Biotin-requiring enzymes attachment site. Similar to other biotin-dependent enzymes and carbamoyl-phosphate synthetases. AccA3 (Rv3285)%2C AccD5 (Rv3280)%2C AccD4 (Rv3799)%2C and AccE5 (Rv3281) form a biotin-dependent acyl-CoA carboxylase in M. tuberculosis H37Rv (See Oh et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accA3;inference=protein motif:PROSITE:PS00867;locus_tag=Rv3285;product=Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP);protein_id=CCP46104.1;transl_table=11
AL123456.3	EMBL	gene	3668169	3668954	.	-	.	ID=gene-Rv3286c;Name=sigF;gbkey=Gene;gene=sigF;gene_biotype=protein_coding;locus_tag=Rv3286c
AL123456.3	EMBL	CDS	3668169	3668954	.	-	0	ID=cds-CCP46105.1;Parent=gene-Rv3286c;Dbxref=EnsemblGenomes-Gn:Rv3286c,EnsemblGenomes-Tr:CCP46105,GOA:P9WGI3,InterPro:IPR000943,InterPro:IPR007624,InterPro:IPR007627,InterPro:IPR007630,InterPro:IPR011991,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,InterPro:IPR014322,NCBI_GP:CCP46105.1;Name=CCP46105.1;Note=Rv3286c%2C (MTCY71.26)%2C len: 261 aa. SigF%2C stress response/stationary phase RNA polymerase sigma factor (see citations below)%2C similar to several Streptomyces RNA polymerase sigma factors e.g. Q9RPC8|sigh from Streptomyces coelicolor A3(2) (354 aa)%2C FASTA scores: opt: 869%2C E(): 1.1e-45%2C (51.15%25 identity in 258 aa overlap)%3B Q9RIT0|SIG1 from Streptomyces coelicolor (361 aa)%2C FASTA scores: opt: 869%2C E(): 1.1e-45%2C (51.15%25 identity in 258 aa overlap)%3B Q9ADM4|2SC10A7.38c from Streptomyces coelicolor (318 aa)%2CFASTA scores: opt: 776%2C E(): 4.6e-40%2C (48.75%25 identity in 240 aa overlap)%3B P37971|RPOF_STRCO|SIGF|RPOX|2SCD60.01c from Streptomyces coelicolor (287 aa)%2C FASTA scores: opt: 717%2C E(): 1.6e-36%2C (44.5%25 identity in 245 aa overlap)%3B P37970|RPOF_STRAU|SIGF|RPOX from Streptomyces aureofaciens (297 aa)%3B etc. Contains possible helix-turn-helix motif at aa 229-250 (+7.38 SD). Similar to the sigma-70 factor family. Seems expressed in stationary phase and under stress conditions in vitro (see citations below).;gbkey=CDS;gene=sigF;locus_tag=Rv3286c;product=Alternative RNA polymerase sigma factor SigF;protein_id=CCP46105.1;transl_table=11
AL123456.3	EMBL	gene	3668951	3669388	.	-	.	ID=gene-Rv3287c;Name=rsbW;gbkey=Gene;gene=rsbW;gene_biotype=protein_coding;gene_synonym=usfX;locus_tag=Rv3287c
AL123456.3	EMBL	CDS	3668951	3669388	.	-	0	ID=cds-CCP46106.1;Parent=gene-Rv3287c;Dbxref=EnsemblGenomes-Gn:Rv3287c,EnsemblGenomes-Tr:CCP46106,GOA:P9WGX7,NCBI_GP:CCP46106.1;Name=CCP46106.1;Note=Rv3287c%2C (MTCY71.27c)%2C len: 145 aa. RsbW (alternate gene name: usfX)%2C anti-sigma factor (see citations below)%2Csimilar to Q49667|B1308_F3_89 from Mycobacterium leprae (75 aa)%2C FASTA scores: opt: 308%2C E(): 2.5e-15%2C (72.2%25 identity in 72 aa overlap)%3B Q9R3X8|PRS1|USHX|PRS PRS1 protein (anti-sigma factor) from Streptomyces coelicolor (137 aa)%2CFASTA scores: opt: 184%2C E(): 3.7e-06%2C (36.8%25 identity in 106 aa overlap)%3B O50231 putative sigma-B regulator from Bacillus licheniformis (160 aa)%2C FASTA scores: opt: 122%2CE(): 0.13%2C (23.9%25 identity in 92 aa overlap)%3B and P17904|RSBW_BACSU anti-sigma B factor (sigma-B negative effector RSBW) from Bacillus subtilis (160 aa)%2C FASTA scores: opt: 108%2C E(): 1.3%2C (21.25%25 identity in 127 aa overlap). Equivalent to AAK47729 from Mycobacterium tuberculosis strain CDC1551 (145 aa) but longer 99 aa. Induction by heat shock%2C salt stress%2C oxidative stress%2Cglucose limitation and oxygen limitation. N-terminus shortened since first submission (previously 242 aa). Binds ATP%2C GTP.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rsbW;locus_tag=Rv3287c;product=Anti-sigma factor RsbW (sigma negative effector);protein_id=CCP46106.1;transl_table=11
AL123456.3	EMBL	gene	3669586	3669999	.	-	.	ID=gene-Rv3288c;Name=usfY;gbkey=Gene;gene=usfY;gene_biotype=protein_coding;locus_tag=Rv3288c
AL123456.3	EMBL	CDS	3669586	3669999	.	-	0	ID=cds-CCP46107.1;Parent=gene-Rv3288c;Dbxref=EnsemblGenomes-Gn:Rv3288c,EnsemblGenomes-Tr:CCP46107,UniProtKB/TrEMBL:L7N685,NCBI_GP:CCP46107.1;Name=CCP46107.1;Note=Rv3288c%2C (MTCY71.28c)%2C len: 137 aa. UsfY%2C putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=usfY;locus_tag=Rv3288c;product=Putative protein UsfY;protein_id=CCP46107.1;transl_table=11
AL123456.3	EMBL	gene	3670034	3670411	.	-	.	ID=gene-Rv3289c;Name=Rv3289c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3289c
AL123456.3	EMBL	CDS	3670034	3670411	.	-	0	ID=cds-CCP46108.1;Parent=gene-Rv3289c;Dbxref=EnsemblGenomes-Gn:Rv3289c,EnsemblGenomes-Tr:CCP46108,GOA:P96894,UniProtKB/TrEMBL:P96894,NCBI_GP:CCP46108.1;Name=CCP46108.1;Note=Rv3289c%2C (MTCY71.29c)%2C len: 125 aa. Possible transmembrane protein%2C showing slight similarity to other membrane proteins or glycoproteins.;gbkey=CDS;locus_tag=Rv3289c;product=Possible transmembrane protein;protein_id=CCP46108.1;transl_table=11
AL123456.3	EMBL	gene	3670445	3671794	.	-	.	ID=gene-Rv3290c;Name=lat;gbkey=Gene;gene=lat;gene_biotype=protein_coding;locus_tag=Rv3290c
AL123456.3	EMBL	CDS	3670445	3671794	.	-	0	ID=cds-CCP46109.1;Parent=gene-Rv3290c;Dbxref=EnsemblGenomes-Gn:Rv3290c,EnsemblGenomes-Tr:CCP46109,GOA:P9WQ77,InterPro:IPR005814,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR017657,PDB:2CIN,PDB:2CJD,PDB:2CJG,PDB:2CJH,PDB:2JJE,PDB:2JJF,PDB:2JJG,PDB:2JJH,NCBI_GP:CCP46109.1;Name=CCP46109.1;Note=Rv3290c%2C (MTCY71.30)%2C len: 449 aa. Probable lat%2Clysine-epsilon aminotransferase%2C similar to Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa)%2C FASTA scores: opt: 1702%2C E(): 1.1e-99%2C (60.35%25 identity in 439 aa overlap)%3B and Q01767|Q53823|LAT_STRCL from Streptomyces clavuligerus (457 aa)%2C FASTA scores: opt: 1676%2C E(): 4.9e-98%2C (60.15%25 identity in 434 aa overlap). Also some similarity to 4-aminobutyrate aminotransferase proteins (gamma-amino-N-butyrate transaminases). Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lat;locus_tag=Rv3290c;product=Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase);protein_id=CCP46109.1;transl_table=11
AL123456.3	EMBL	gene	3671845	3672297	.	-	.	ID=gene-Rv3291c;Name=lrpA;gbkey=Gene;gene=lrpA;gene_biotype=protein_coding;locus_tag=Rv3291c
AL123456.3	EMBL	CDS	3671845	3672297	.	-	0	ID=cds-CCP46110.1;Parent=gene-Rv3291c;Dbxref=EnsemblGenomes-Gn:Rv3291c,EnsemblGenomes-Tr:CCP46110,GOA:I6YBQ3,InterPro:IPR000485,InterPro:IPR011008,InterPro:IPR011991,InterPro:IPR019887,InterPro:IPR019888,UniProtKB/TrEMBL:I6YBQ3,NCBI_GP:CCP46110.1;Name=CCP46110.1;Note=Rv3291c%2C (MTCY71.31c)%2C len: 150 aa. Probable lrpA%2Ctranscriptional regulator Lrp/AsnC-family%2C similar to other regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces coelicolor (165 aa)%2C FASTA scores: opt: 503%2C E(): 9.1e-26%2C(50.35%25 identity in 143 aa overlap)%3B Q9KYP0|SCD69.13 from Streptomyces coelicolor (167 aa)%2C FASTA scores: opt: 310%2CE(): 2.7e-13%2C (37.2%25 identity in 129 aa overlap)%3B BAB50701|MLL3910 from Rhizobium loti (Mesorhizobium loti) (152 aa)%2C FASTA scores: opt: 282%2C E(): 1.6e-11%2C (39.55%25 identity in 129 aa overlap)%3B O87635|LRP_KLEAE from Klebsiella aerogenes (163 aa)%2C FASTA scores: opt: 279%2C E(): 2.5e-11%2C (38.1%25 identity in 147 aa overlap)%3B etc. Contains helix-turn-helix motif at aa 22-43 (+3.94 SD). Could belong to the Lrp/AsnC family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lrpA;locus_tag=Rv3291c;product=Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family);protein_id=CCP46110.1;transl_table=11
AL123456.3	EMBL	gene	3672328	3673575	.	+	.	ID=gene-Rv3292;Name=Rv3292;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3292
AL123456.3	EMBL	CDS	3672328	3673575	.	+	0	ID=cds-CCP46111.1;Parent=gene-Rv3292;Dbxref=EnsemblGenomes-Gn:Rv3292,EnsemblGenomes-Tr:CCP46111,InterPro:IPR009770,NCBI_GP:CCP46111.1;Name=CCP46111.1;Note=Rv3292%2C (MTCY71.32)%2C len: 415 aa. Conserved hypothetical protein%2C similar to P76097|YDCJ_ECOLI|B1423 hypothetical 51.0 KDA protein from Escherichia coli strain K12 (447 aa)%2C FASTA scores: opt: 747%2C E(): 5.6e-39%2C (38.55%25 identity in 449 aa overlap)%3B BAB35451|ECS2028 hypothetical 51.0 KDA protein from Escherichia coli strain O157:H7 (447 aa)%2C FASTA scores: opt: 744%2C E(): 8.6e-39%2C (38.3%25 identity in 449 aa overlap)%3B AAG56352|Z2297 protein from Escherichia coli O157:H7 EDL933 (212 aa)%2C FASTA scores: opt: 454%2C E(): 4.6e-21%2C (41.75%25 identity in 206 aa overlap)%3B and similar in part with Q49664|B1308_C1_136 from Mycobacterium leprae (71 aa)%2C FASTA scores: opt: 305%2C E(): 3.2e-12%2C (70.0%25 identity in 70 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3292;product=Conserved hypothetical protein;protein_id=CCP46111.1;transl_table=11
AL123456.3	EMBL	gene	3673602	3675086	.	+	.	ID=gene-Rv3293;Name=pcd;gbkey=Gene;gene=pcd;gene_biotype=protein_coding;gene_synonym=aldB;locus_tag=Rv3293
AL123456.3	EMBL	CDS	3673602	3675086	.	+	0	ID=cds-CCP46112.1;Parent=gene-Rv3293;Dbxref=EnsemblGenomes-Gn:Rv3293,EnsemblGenomes-Tr:CCP46112,GOA:L7N650,InterPro:IPR015590,InterPro:IPR016161,InterPro:IPR016162,InterPro:IPR016163,InterPro:IPR029510,UniProtKB/TrEMBL:L7N650,NCBI_GP:CCP46112.1;Name=CCP46112.1;Note=Rv3293%2C (MTCY71.33)%2C len: 494 aa. Probable pcd%2Cpiperideine-6-carboxylic acid dehydrogenase%2C highly similar to others e.g. O85725|PCD semialdehyde dehydrogenase from Streptomyces clavuligerus (512 aa)%2C FASTA scores: opt: 2214%2C E(): 6.7e-121%2C (68.75%25 identity in 496 aa overlap) (see Alexander %26 Jensen 1998)%3B Q9I4U7|PA1027 probable aldehyde dehydrogenase from Pseudomonas aeruginosa (529 aa)%2C FASTA scores: opt: 1984%2C E(): 1.4e-107%2C (64.5%25 identity in 493 aa overlap)%3B BAB49892|MLL2867 aldehyde dehydrogenase from Rhizobium loti (Mesorhizobium loti) (504 aa)%2C FASTA scores: opt: 1964%2C E(): 2e-106%2C (62.8%25 identity in 476 aa overlap)%3B Q9A8Y1|CC1216 aldehyde dehydrogenase from Caulobacter crescentus (507 aa)%2C FASTA scores: opt: 1909%2C E(): 3.1e-103%2C (59.95%25 identity in 497 aa overlap)%3B O54199|PCD piperideine-6-carboxilic acid dehydrogenase from Streptomyces clavuligerus (496 aa)%2C FASTA scores: opt: 1748%2C E(): 6.4e-94%2C (60.6%25 identity in 467 aa overlap)%3B and Q9F1U8|PCD piperideine-6-carboxylate dehydrogenase from 'Flavobacterium' lutescens (510 aa)%2C FASTA scores: opt: 1656%2C E(): 1.4e-88%2C (54.05%25 identity in 481 aa overlap) (see Fujii et al.%2C 2000)%3B etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Note that ORF Rv3290c seems to encoded the putative lat enzyme. Note that previously known as aldB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pcd;inference=protein motif:PROSITE:PS00687;locus_tag=Rv3293;product=Probable piperideine-6-carboxilic acid dehydrogenase Pcd (piperideine-6-carboxylate dehydrogenase);protein_id=CCP46112.1;transl_table=11
AL123456.3	EMBL	gene	3675186	3675995	.	-	.	ID=gene-Rv3294c;Name=Rv3294c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3294c
AL123456.3	EMBL	CDS	3675186	3675995	.	-	0	ID=cds-CCP46113.1;Parent=gene-Rv3294c;Dbxref=EnsemblGenomes-Gn:Rv3294c,EnsemblGenomes-Tr:CCP46113,InterPro:IPR025420,UniProtKB/TrEMBL:L7N658,NCBI_GP:CCP46113.1;Name=CCP46113.1;Note=Rv3294c%2C len: 269 aa. Conserved hypothetical protein%2C similar to several conserved hypothetical proteins from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa)%2CFASTA scores: opt: 682%2C E(): 3.6e-37%2C (44.85%25 identity in 243 aa overlap)%3B O53329|Rv3179 (454 aa)%2C FASTA scores: opt: 561%2C E(): 3.3e-29%2C (42.20%25 identity in 218 aa overlap)%3B Q10849|YK08_MYCTU|Rv2008c (441 aa)%2C FASTA scores: opt: 194%2CE(): 3.9e-05%2C (30.10%25 identity in 239 aa overlap). Also some similarity with proteins from other organisms. Replace previous Rv3294 on opposite strand.;gbkey=CDS;locus_tag=Rv3294c;product=Conserved hypothetical protein;protein_id=CCP46113.1;transl_table=11
AL123456.3	EMBL	gene	3676066	3676731	.	+	.	ID=gene-Rv3295;Name=Rv3295;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3295
AL123456.3	EMBL	CDS	3676066	3676731	.	+	0	ID=cds-CCP46114.1;Parent=gene-Rv3295;Dbxref=EnsemblGenomes-Gn:Rv3295,EnsemblGenomes-Tr:CCP46114,GOA:P96900,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,UniProtKB/TrEMBL:P96900,NCBI_GP:CCP46114.1;Name=CCP46114.1;Note=Rv3295%2C (MTCY71.35)%2C len: 221 aa. Probable transcriptional regulator TetR-family%2C equivalent to Q9CCL4|ML0717 putative TetR-family transcriptional regulator from Mycobacterium leprae (223 aa)%2C FASTA scores: opt: 1260%2C E(): 7.2e-75%2C (85.45%25 identity in 220 aa overlap). Also highly similar to other streptomyces regulators e.g. Q9RD77|SCF43.11 from Streptomyces coelicolor (205 aa)%2C FASTA scores: opt: 442%2C E(): 9.8e-22%2C(38.6%25 identity in 202 aa overlap)%3B Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa)%2C FASTA scores: opt: 215%2CE(): 5.9e-07%2C (31.85%25 identity in 135 aa overlap)%3B Q9L0U5|SCD35.06 from Streptomyces coelicolor (240 aa)%2CFASTA scores: opt: 214%2C E(): 7.4e-07%2C (28.2%25 identity in 156 aa overlap)%3B etc. Similar to the TetR/AcrR family of transcriptional regulators. Contains potential helix-turn-helix motif at aa 33-54 (+4.42 SD).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3295;product=Probable transcriptional regulatory protein (probably TetR-family);protein_id=CCP46114.1;transl_table=11
AL123456.3	EMBL	gene	3676775	3681316	.	+	.	ID=gene-Rv3296;Name=lhr;gbkey=Gene;gene=lhr;gene_biotype=protein_coding;locus_tag=Rv3296
AL123456.3	EMBL	CDS	3676775	3681316	.	+	0	ID=cds-CCP46115.1;Parent=gene-Rv3296;Dbxref=EnsemblGenomes-Gn:Rv3296,EnsemblGenomes-Tr:CCP46115,GOA:P96901,InterPro:IPR001650,InterPro:IPR003593,InterPro:IPR011545,InterPro:IPR013701,InterPro:IPR014001,InterPro:IPR027417,UniProtKB/TrEMBL:P96901,NCBI_GP:CCP46115.1;Name=CCP46115.1;Note=Rv3296%2C (MTCY71.36)%2C len: 1513 aa. Probable lhr%2CATP-dependent helicase%2C similar to others e.g. P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 (1538 aa)%2C FASTA scores: opt: 2930%2C E(): 1.5e-159%2C (47.55%25 identity in 1569 aa overlap)%3B AAG56642|LHR from Escherichia coli stain O157:H7 EDL933 (1538 aa)%2C FASTA scores: opt: 2930%2C E(): 1.5e-159%2C (47.6%25 identity in 1561 aa overlap)%3B O86821|SC7C7.16c from Streptomyces coelicolor (1690 aa)%2CFASTA scores: opt: 2919%2C E(): 7e-159%2C (53.55%25 identity in 1703 aa overlap)%3B Q9HYW9|PA3272 from Pseudomonas aeruginosa (1448 aa)%2C FASTA scores: opt: 907%2C E(): 6.2e-44%2C (35.85%25 identity in 1512 aa overlap)%3B etc. Similar to dead/DEAH box helicase family and to helicase C-terminal domain. Contains PS00017 ATP/GTP-binding site motif A and possible helix-turn-helix motif.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lhr;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3296;product=Probable ATP-dependent helicase Lhr (large helicase-related protein);protein_id=CCP46115.1;transl_table=11
AL123456.3	EMBL	gene	3681320	3682087	.	+	.	ID=gene-Rv3297;Name=nei;gbkey=Gene;gene=nei;gene_biotype=protein_coding;locus_tag=Rv3297
AL123456.3	EMBL	CDS	3681320	3682087	.	+	0	ID=cds-CCP46116.1;Parent=gene-Rv3297;Dbxref=EnsemblGenomes-Gn:Rv3297,EnsemblGenomes-Tr:CCP46116,GOA:P9WNC1,InterPro:IPR000214,InterPro:IPR010979,InterPro:IPR012319,InterPro:IPR015886,InterPro:IPR015887,NCBI_GP:CCP46116.1;Name=CCP46116.1;Note=Rv3297%2C (MTCY71.37%2C MT3396)%2C len: 255 aa. Probable nei%2C endonuclease VIII (see citation below)%2C similar to others e.g. O86820|END8_STRCO|NEI|SC7C7.15c from Streptomyces coelicolor (276 aa)%2C FASTA scores: opt: 770%2CE(): 1.2e-42%2C (50.35%25 identity in 268 aa overlap)%3B P50465|END8_ECOLI|NEI|B0714 from Escherichia coli strain K12 (262 aa)%2C FASTA scores: opt: 310%2C E(): 6.3e-13%2C (28.1%25 identity in 267 aa overlap)%3B AAG55037|NEI from Escherichia coli strain O157:H7 EDL933 (263 aa)%2C FASTA scores: opt: 301%2C E(): 2.4e-12%2C (27.7%25 identity in 267 aa overlap)%3B etc. Belongs to the FPG family.;gbkey=CDS;gene=nei;locus_tag=Rv3297;product=Probable endonuclease VIII Nei;protein_id=CCP46116.1;transl_table=11
AL123456.3	EMBL	gene	3682110	3683024	.	-	.	ID=gene-Rv3298c;Name=lpqC;gbkey=Gene;gene=lpqC;gene_biotype=protein_coding;locus_tag=Rv3298c
AL123456.3	EMBL	CDS	3682110	3683024	.	-	0	ID=cds-CCP46117.1;Parent=gene-Rv3298c;Dbxref=EnsemblGenomes-Gn:Rv3298c,EnsemblGenomes-Tr:CCP46117,InterPro:IPR029058,UniProtKB/TrEMBL:P96903,NCBI_GP:CCP46117.1;Name=CCP46117.1;Note=Rv3298c%2C (MTCY71.38c)%2C len: 304 aa. Possible lpqC%2Cesterase lipoprotein%2C equivalent to Q9CCL5|LPQC|ML0715 putative secreted hydrolase from Mycobacterium leprae (304 aa)%2C FASTA scores: opt: 1543%2C E(): 1.3e-87%2C (71.6%25 identity in 303 aa overlap)%3B and Q49658|B1308_F2_43 tubulin family protein from Mycobacterium leprae (302 aa)%2C FASTA scores: opt: 1541%2C E(): 1.7e-87%2C (72.0%25 identity in 300 aa overlap). Also similar to Q9I5Z3|PA0543 hypothetical protein from Pseudomonas aeruginosa (322 aa)%2C FASTA scores: opt: 439%2C E(): 8.9e-20%2C (32.3%25 identity in 319 aa overlap)%3B Q9F2K9|SCH63.19c putative secreted protein from Streptomyces coelicolor (348 aa)%2C FASTA scores: opt: 394%2CE(): 5.5e-17%2C (30.25%25 identity in 334 aa overlap)%3B etc. And similar to O86367|LPQP|Rv0671|MTCI376.03c from Mycobacterium tuberculosis strain H37Rv (280 aa)%2C FASTA scores: opt: 519%2C E(): 9.8e-25%2C (39.25%25 identity in 275 aa overlap). Probably lipoprotein%2C esterase membrane-bound%2Cwith 18 aa signal sequence as it contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqC;locus_tag=Rv3298c;product=Possible esterase lipoprotein LpqC;protein_id=CCP46117.1;transl_table=11
AL123456.3	EMBL	gene	3683051	3685963	.	-	.	ID=gene-Rv3299c;Name=atsB;gbkey=Gene;gene=atsB;gene_biotype=protein_coding;locus_tag=Rv3299c
AL123456.3	EMBL	CDS	3683051	3685963	.	-	0	ID=cds-CCP46118.1;Parent=gene-Rv3299c;Dbxref=EnsemblGenomes-Gn:Rv3299c,EnsemblGenomes-Tr:CCP46118,GOA:O65931,InterPro:IPR000917,InterPro:IPR009200,InterPro:IPR017849,InterPro:IPR017850,InterPro:IPR024607,UniProtKB/TrEMBL:O65931,NCBI_GP:CCP46118.1;Name=CCP46118.1;Note=Rv3299c%2C (MTCI418A.01c%2C MTCY71.39c)%2C len: 970 aa. Probable atsB%2C arylsulfatase%2C similar to P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from Pseudomonas aeruginosa (535 aa)%2C FASTA scores: opt: 645%2CE(): 5.8e-31%2C (32.0%25 identity in 550 aa overlap)%3B Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa)%2C FASTA scores: opt: 504%2C E(): 1.7e-22%2C (26.3%25 identity in 566 aa overlap)%3B and P20713|ATSA|ARS_KLEAE (precursor) from Klebsiella pneumoniae (464 aa)%2C FASTA scores: opt: 502%2CE(): 1.8e-22%2C (26.85%25 identity in 451 aa overlap). Also similar to Mycobacterium tuberculosis proteins O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6%25 identity in 796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa) (38.4%25 identity in 797 aa overlap). Equivalent to AAK47741 from Mycobacterium tuberculosis strain CDC1551 (992 aa) but shorter 22 aa. Contains PS00523 Sulfatases signature 1 and PS01095 Chitinases family 18 active site signature. Belongs to the sulfatase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=atsB;inference=protein motif:PROSITE:PS01095;locus_tag=Rv3299c;product=Probable arylsulfatase AtsB (aryl-sulfate sulphohydrolase) (sulfatase);protein_id=CCP46118.1;transl_table=11
AL123456.3	EMBL	gene	3685983	3686900	.	-	.	ID=gene-Rv3300c;Name=Rv3300c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3300c
AL123456.3	EMBL	CDS	3685983	3686900	.	-	0	ID=cds-CCP46119.1;Parent=gene-Rv3300c;Dbxref=EnsemblGenomes-Gn:Rv3300c,EnsemblGenomes-Tr:CCP46119,GOA:O07166,InterPro:IPR006145,InterPro:IPR006224,InterPro:IPR020103,UniProtKB/TrEMBL:O07166,NCBI_GP:CCP46119.1;Name=CCP46119.1;Note=Rv3300c%2C (MTCI418A.02c)%2C len: 305 aa. Conserved hypothetical protein%2C similar to various proteins (notably pseudoridine synthase family proteins) e.g. Q9RJ76|SCI41.08 putative ribosomal pseudouridine synthase from Streptomyces coelicolor (324 aa)%2C FASTA scores: opt: 876%2C E(): 4.5e-48%2C(52.1%25 identity in 313 aa overlap)%3B Q9I272|PA2043 hypothetical protein from Pseudomonas aeruginosa (300 aa)%2CFASTA scores: opt: 676%2C E(): 1.8e-35%2C (42.55%25 identity in 268 aa overlap)%3B Q9JZW8|NMB0867 YABO/YCEC/SFHB family protein from Neisseria meningitidis (serogroup B) (307 aa)%2CFASTA scores: opt: 597%2C E(): 1.8e-30%2C (42.9%25 identity in 282 aa overlap)%3B Q9JUY2|NMA1085 hypothetical protein from Neisseria meningitidis (serogroup A) (307 aa)%2C FASTA scores: opt: 597%2C E(): 1.8e-30%2C (42.9%25 identity in 282 aa overlap)%3B Q12362|RIB2_YEAST|RIB2|YOL066C DRAP deaminase (pseudouridine synthase family protein) from Saccharomyces cerevisiae (Baker's yeast) (591 aa)%2C FASTA scores: opt: 338%2C E(): 6.9e-14%2C (32.95%25 identity in 246 aa overlap)%3B Q9RTS2|DR1684 putative pseudouridine synthase from Deinococcus radiodurans (321 aa)%2C FASTA scores: opt: 319%2CE(): 6.5e-13%2C (32.75%25 identity in 235 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308 aa) (28.8%25 identity in 299 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3300c;product=Conserved hypothetical protein;protein_id=CCP46119.1;transl_table=11
AL123456.3	EMBL	gene	3686912	3687577	.	-	.	ID=gene-Rv3301c;Name=phoY1;gbkey=Gene;gene=phoY1;gene_biotype=protein_coding;locus_tag=Rv3301c
AL123456.3	EMBL	CDS	3686912	3687577	.	-	0	ID=cds-CCP46120.1;Parent=gene-Rv3301c;Dbxref=EnsemblGenomes-Gn:Rv3301c,EnsemblGenomes-Tr:CCP46120,GOA:P9WI97,InterPro:IPR026022,InterPro:IPR028366,NCBI_GP:CCP46120.1;Name=CCP46120.1;Note=Rv3301c%2C (MTCI418A.03c)%2C len: 221 aa. Probable phoY1%2C phosphate-transport system regulatory protein%2Chighly similar to Q50047|phoY|PHOU1|PHOY1|ML2188 phosphate transport system protein PHOU homolog 1 from Mycobacterium leprae (222 aa)%2C FASTA scores: opt: 929%2C E(): 7.8e-51%2C(61.45%25 identity in 218 aa overlap). Also highly similar to Q9FCE2|2SCD46.42c putative regulatory protein (fragment) from Streptomyces coelicolor (123 aa)%2C FASTA scores: opt: 324%2C E(): 1.8e-13%2C (43.65%25 identity in 103 aa overlap)%3B Q9L0R3|SCD8A.01c putative phosphate transport system regulatory protein (fragment) from Streptomyces coelicolor (139 aa)%2C FASTA scores: opt: 309%2C E(): 1.7e-12%2C (36.7%25 identity in 139 aa overlap)%3B Q52989|PHOU_RHIME phosphate transport system protein from Rhizobium meliloti (Sinorhizobium meliloti) (237 aa)%2C FASTA scores: opt: 292%2CE(): 3.1e-11%2C (26.3%25 identity in 213 aa overlap)%3B etc. And highly similar to Mycobacterium tuberculosis O53833|PHU2_MYCTU|MTV043_13c|PHOU2|PHOY2|Rv0821c|MT0843 phosphate transport system protein PHOU homolog 2 (213 aa) (63.4%25 identity in 213 aa overlap). Belongs to the PHOU family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=phoY1;locus_tag=Rv3301c;product=Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1;protein_id=CCP46120.1;transl_table=11
AL123456.3	EMBL	gene	3687685	3689442	.	-	.	ID=gene-Rv3302c;Name=glpD2;gbkey=Gene;gene=glpD2;gene_biotype=protein_coding;locus_tag=Rv3302c
AL123456.3	EMBL	CDS	3687685	3689442	.	-	0	ID=cds-CCP46121.1;Parent=gene-Rv3302c;Dbxref=EnsemblGenomes-Gn:Rv3302c,EnsemblGenomes-Tr:CCP46121,GOA:P9WN79,InterPro:IPR000447,InterPro:IPR006076,NCBI_GP:CCP46121.1;Name=CCP46121.1;Note=Rv3302c%2C (MTCI418A.04c%2C MTV016.01c)%2C len: 585 aa. Probable glpd2%2C glycerol-3-phosphate dehydrogenase%2Cequivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 glycerol-3-phosphate dehydrogenase from Mycobacterium leprae (585 aa)%2C FASTA scores: opt: 3489%2C E(): 2.2e-198%2C(90.75%25 identity in 584 aa overlap). Also highly similar to many e.g. Q9L0I3|SCD63.06 from Streptomyces coelicolor (568 aa)%2C FASTA scores: opt: 2203%2C E(): 1.6e-122%2C (59.95%25 identity in 564 aa overlap)%3B Q9RVK8|DR1019 from Deinococcus radiodurans (522 aa)%2C FASTA scores: opt: 949%2C E(): 1.4e-48%2C(37.0%25 identity in 538 aa overlap)%3B BAB53412|MLR7270 from Rhizobium loti (Mesorhizobium loti) (505 aa)%2C FASTA scores: opt: 861%2C E(): 2.2e-43%2C (37.3%25 identity in 488 aa overlap)%3B P18158|GLPD_BACSU from B. subtilis (555 aa)%2C FASTA scores: opt: 768%2C E(): 7.2e-38%2C (32.85%25 identity in 484 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis protein Q10502|GLPD_MYCTU|MTCY427_31c|Rv2249c glycerol-3-phosphate dehydrogenase (516 aa)%2C FASTA scores: opt: 843%2C E(): 2.6e-42%2C (36.5%25 identity in 515 aa overlap). Contains PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. Cofactor: FAD (by similarity). Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glpD2;inference=protein motif:PROSITE:PS00978;locus_tag=Rv3302c;product=Probable glycerol-3-phosphate dehydrogenase GlpD2;protein_id=CCP46121.1;transl_table=11
AL123456.3	EMBL	gene	3689457	3690938	.	-	.	ID=gene-Rv3303c;Name=lpdA;gbkey=Gene;gene=lpdA;gene_biotype=protein_coding;locus_tag=Rv3303c
AL123456.3	EMBL	CDS	3689457	3690938	.	-	0	ID=cds-CCP46122.1;Parent=gene-Rv3303c;Dbxref=EnsemblGenomes-Gn:Rv3303c,EnsemblGenomes-Tr:CCP46122,GOA:P9WHH7,InterPro:IPR001327,InterPro:IPR004099,InterPro:IPR013027,InterPro:IPR016156,InterPro:IPR023753,PDB:1XDI,NCBI_GP:CCP46122.1;Name=CCP46122.1;Note=Rv3303c%2C (MTV016.02c)%2C len: 493 aa. Probable lpdA%2Cquinone reductase%2C similar to e.g. Q9EWV3|2SCK31.22c putative oxidoreductase from Streptomyces coelicolor (475 aa)%2C FASTA scores: opt: 1420%2C E(): 2.4e-77%2C (54.9%25 identity in 471 aa overlap)%3B Q9A7J2|CC1731 lipoamide dehydrogenase (E3 component%2Cpyruvate dehydrogenase complex) from Caulobacter crescentus (466 aa)%2C FASTA scores: opt: 696%2CE(): 3.6e-34%2C (29.6%25 identity in 463 aa overlap)%3B Q04829|LPD|DLDH_HALVO dihydrolipoamide dehydrogenase from Halobacterium volcanii (Haloferax volcanii) (474 aa)%2C FASTA scores: opt: 675%2C E(): 6.5e-33%2C (29.3%25 identity in 471 aa overlap)%3B P50970|DLDH_ZYMMO|LPD dihydrolipoamide dehydrogenase from Zymomonas mobilis%2C FASTA scores: opt: 658%2C E(): 6.6e-32%2C (30.4%25 identity in 464 aa overlap)%3B etc. Belongs to the pyridine nucleotide-disulfide oxidoreductases class-I. Cofactor: FAD.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpdA;locus_tag=Rv3303c;product=NAD(P)H quinone reductase LpdA;protein_id=CCP46122.1;transl_table=11
AL123456.3	EMBL	gene	3691141	3691620	.	+	.	ID=gene-Rv3304;Name=Rv3304;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3304
AL123456.3	EMBL	CDS	3691141	3691620	.	+	0	ID=cds-CCP46123.1;Parent=gene-Rv3304;Dbxref=EnsemblGenomes-Gn:Rv3304,EnsemblGenomes-Tr:CCP46123,GOA:O53356,InterPro:IPR013024,InterPro:IPR017939,UniProtKB/TrEMBL:O53356,NCBI_GP:CCP46123.1;Name=CCP46123.1;Note=Rv3304%2C (MTV016.03)%2C len: 159 aa. Conserved protein%2Cvery similar to Q9CCL6|ML0711 hypothetical protein from Mycobacterium leprae (159 aa)%2C FASTA scores: opt: 1041%2CE(): 6.1e-62%2C (91.8%25 identity in 159 aa overlap)%3B and Q49927|L308_F3_97 from M. leprae (174 aa)%2C FASTA scores: opt: 974%2C E(): 1.8e-57%2C (91.2%25 identity in 149 aa overlap). Also highly similar to Q9AD81|SCK13.10c conserved hypothetical protein from Streptomyces coelicolor (145 aa)%2CFASTA scores: opt: 615%2C E(): 7.8e-34%2C (60.55%25 identity in 147 aa overlap)%3B and shows some similarity to other various hypotheticals proteins. ORF continues upstream with possible start at 2198 (equivalent to AAK47746 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 53 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3304;product=Conserved protein;protein_id=CCP46123.1;transl_table=11
AL123456.3	EMBL	gene	3691639	3692808	.	-	.	ID=gene-Rv3305c;Name=amiA1;gbkey=Gene;gene=amiA1;gene_biotype=protein_coding;gene_synonym=amiA;locus_tag=Rv3305c
AL123456.3	EMBL	CDS	3691639	3692808	.	-	0	ID=cds-CCP46124.1;Parent=gene-Rv3305c;Dbxref=EnsemblGenomes-Gn:Rv3305c,EnsemblGenomes-Tr:CCP46124,GOA:L7N663,InterPro:IPR002933,InterPro:IPR011650,InterPro:IPR017439,UniProtKB/TrEMBL:L7N663,NCBI_GP:CCP46124.1;Name=CCP46124.1;Note=Rv3305c%2C (MTV016.04c)%2C len: 389 aa. Possible amiA1%2CN-acyl-L-amino acid amidohydrolase (or peptidase)%2C similar to many proteins e.g. Q9AK43|2SCK8.09 putative peptidase from Streptomyces coelicolor (410 aa)%2C FASTA scores: opt: 1015%2C E(): 3.9e-54%2C (50.8%25 identity in 374 aa overlap)%3B Q9UZ30|PAB0873 amino acid amidohydrolase from Pyrococcus abyssi (383 aa)%2C FASTA scores: opt: 823%2C E(): 1.6e-42%2C(38.2%25 identity in 369 aa overlap)%3B O58453|PH0722 long hypothetical amino acid amidohydrolase from Pyrococcus horikoshii (388 aa)%2C FASTA scores: opt: 815%2C E(): 4.8e-42%2C(38.75%25 identity in 369 aa overlap)%3B O34980|YTNL_BACSU hypothetical 45.2 KDA protein from B. subtilis (416 aa)%2CFASTA scores: opt: 805%2C E(): 2.1e-41%2C (37.85%25 identity in 367 aa overlap)%3B Q9KCF8|BH1613 N-acyl-L-amino acid amidohydrolase from Bacillus halodurans (404 aa)%2C FASTA scores: opt: 795%2C E(): 8.1e-41%2C (37.7%25 identity in 382 aa overlap)%3B BAB50445|MLR3583 hypothetical hippurate hydrolase from Rhizobium loti (Mesorhizobium loti) (387 aa)%2C FASTA scores: opt: 761%2C E(): 8.9e-39%2C (37.65%25 identity in 385 aa overlap)%3B Q9RXH4|DR0339 putative N-acyl-L-amino acid amidohydrolase from Deinococcus radiodurans (392 aa)%2C FASTA scores: opt: 745%2C E(): 8.4e-38%2C (36.15%25 identity in 379 aa overlap)%3B etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. Note that previously known as amiA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=amiA1;inference=protein motif:PROSITE:PS00639;locus_tag=Rv3305c;product=Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase);protein_id=CCP46124.1;transl_table=11
AL123456.3	EMBL	gene	3692805	3693989	.	-	.	ID=gene-Rv3306c;Name=amiB1;gbkey=Gene;gene=amiB1;gene_biotype=protein_coding;gene_synonym=amiB;locus_tag=Rv3306c
AL123456.3	EMBL	CDS	3692805	3693989	.	-	0	ID=cds-CCP46125.1;Parent=gene-Rv3306c;Dbxref=EnsemblGenomes-Gn:Rv3306c,EnsemblGenomes-Tr:CCP46125,GOA:L7N690,InterPro:IPR002933,InterPro:IPR011650,InterPro:IPR017144,InterPro:IPR017439,UniProtKB/TrEMBL:L7N690,NCBI_GP:CCP46125.1;Name=CCP46125.1;Note=Rv3306c%2C (MTV016.05c)%2C len: 394 aa. Probable amiB1%2Caminohydrolase%2C similar to several belonging to peptidase family M40 (and to hypothetical proteins) e.g. P54983|AMHX_BACSU amidohydrolase AMHX from Bacillus subtilis (389 aa)%2C FASTA scores: opt: 286%2C E(): 9.9e-10%2C(26.6%25 identity in 351 aa overlap)%3B P76052|ABGB_ECOLI Aminobenzoyl-glutamate utilizatio from Escherichia coli (481 aa)%2C FASTA scores: opt: 383%2C E(): 2.1e-15%2C (30.5%25 identity in 328 aa overlap)%3B P44765|YDAJ_HAEIN hypothetical protein HI0584 from Haemophilus influenzae (423 aa)%2C FASTA scores: opt: 297%2C E(): 2.4e-10%2C (29.6%25 identity in 274 aa overlap). Note that previously known as amiB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=amiB1;locus_tag=Rv3306c;product=Probable amidohydrolase AmiB1 (aminohydrolase);protein_id=CCP46125.1;transl_table=11
AL123456.3	EMBL	gene	3694054	3694860	.	+	.	ID=gene-Rv3307;Name=deoD;gbkey=Gene;gene=deoD;gene_biotype=protein_coding;gene_synonym=punA;locus_tag=Rv3307
AL123456.3	EMBL	CDS	3694054	3694860	.	+	0	ID=cds-CCP46126.1;Parent=gene-Rv3307;Dbxref=EnsemblGenomes-Gn:Rv3307,EnsemblGenomes-Tr:CCP46126,GOA:P9WP01,InterPro:IPR000845,InterPro:IPR001369,InterPro:IPR011268,InterPro:IPR011269,InterPro:IPR018099,PDB:1G2O,PDB:1I80,PDB:1N3I,PDB:3IOM,PDB:3SCZ,NCBI_GP:CCP46126.1;Name=CCP46126.1;Note=Rv3307%2C (MTV016.06)%2C len: 268 aa. Probable deoD (alternate gene name: punA)%2C purine nucleoside phosphorylase%2C similar to others especially P46862|PUNA_MYCLE|DEOD_MYCLE|ML0707|L308_F2_56 from M. leprae (268 aa)%2C FASTA scores: opt: 1373%2C E(): 1.5e-74%2C(82.05%25 identity in 262 aa overlap)%3B Q9EWV2|2SCK31.24 from Streptomyces coelicolor (274 aa)%2C FASTA scores: opt: 1026%2CE(): 6.4e-54%2C (60.5%25 identity in 266 aa overlap)%3B P81989|PUNA_CELSP from Cellulomonas sp (282 aa)%2C FASTA scores: opt: 963%2C E(): 3.6e-50%2C (58.9%25 identity in 270 aa overlap)%3B Q9X1T2|TM1596 from Thermotoga maritima (265 aa)%2CFASTA scores: opt: 584%2C E(): 1.1e-27%2C (39.55%25 identity in 263 aa overlap)%3B etc. Belongs to the PNP/MTAP family 2 of phosphorylases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=deoD;locus_tag=Rv3307;product=Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP);protein_id=CCP46126.1;transl_table=11
AL123456.3	EMBL	gene	3694864	3696468	.	+	.	ID=gene-Rv3308;Name=pmmB;gbkey=Gene;gene=pmmB;gene_biotype=protein_coding;locus_tag=Rv3308
AL123456.3	EMBL	CDS	3694864	3696468	.	+	0	ID=cds-CCP46127.1;Parent=gene-Rv3308;Dbxref=EnsemblGenomes-Gn:Rv3308,EnsemblGenomes-Tr:CCP46127,GOA:O53360,InterPro:IPR005841,InterPro:IPR005843,InterPro:IPR005844,InterPro:IPR005845,InterPro:IPR005846,InterPro:IPR016055,InterPro:IPR016066,UniProtKB/TrEMBL:O53360,NCBI_GP:CCP46127.1;Name=CCP46127.1;Note=Rv3308%2C (MTV016.07)%2C len: 534 aa. Probable pmmB%2Cphosphomannomutase%2C equivalent to Q9CCL7|PMMB|ML0706 putative phospho-sugar mutase from Mycobacterium leprae (538 aa)%2C FASTA scores: opt: 2681%2C E(): 1.4e-150%2C (76.95%25 identity in 538 aa overlap). Also similar to others e.g. Q9AD82|SCK13.08c from Streptomyces coelicolor (549 aa)%2CFASTA scores: opt: 1378%2C E(): 8.9e-74%2C (46.7%25 identity in 529 aa overlap)%3B Q9ZHL4|PMM (fragment so no homology at N-terminus for this one) from Haemophilus ducreyi (443 aa)%2CFASTA scores: opt: 935%2C E(): 9.6e-48%2C (39.4%25 identity in 449 aa overlap)%3B P18159|YHXB_BACSU from Bacillus subtilis (565 aa)%2C FASTA scores: opt: 776%2C E(): 2.7e-38%2C (31.7%25 identity in 574 aa overlap)%3B etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. Belongs to the phosphohexose mutases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pmmB;inference=protein motif:PROSITE:PS00710;locus_tag=Rv3308;product=Probable phosphomannomutase PmmB (phosphomannose mutase);protein_id=CCP46127.1;transl_table=11
AL123456.3	EMBL	gene	3696470	3697093	.	-	.	ID=gene-Rv3309c;Name=upp;gbkey=Gene;gene=upp;gene_biotype=protein_coding;locus_tag=Rv3309c
AL123456.3	EMBL	CDS	3696470	3697093	.	-	0	ID=cds-CCP46128.1;Parent=gene-Rv3309c;Dbxref=EnsemblGenomes-Gn:Rv3309c,EnsemblGenomes-Tr:CCP46128,GOA:P9WFF3,InterPro:IPR005765,InterPro:IPR029057,NCBI_GP:CCP46128.1;Name=CCP46128.1;Note=Rv3309c%2C (MTV016.08c)%2C len: 207 aa. Probable upp%2Curacil phosphoribosyltransferase%2C identical to P94928|UPP uracil phosphoribosyltransferase from Mycobacterium bovis (207 aa). Also similar to others e.g. P36399|UPP_STRSL from Streptococcus salivarius (209 aa)%2C FASTA scores: opt: 658%2CE(): 4.7e-35%2C (48.3%25 identity in 207 aa overlap)%3B Q9A194|UPP|SPY0392 from Streptococcus pyogenes (209 aa)%2CFASTA scores: opt:650%2C E(): 1.5e-34%2C (47.35%25 identity in 207 aa overlap)%3B Q9RE01|UPP from Lactobacillus plantarum (209 aa)%2C FASTA scores: opt: 644%2C E(): 3.7e-34%2C (46.4%25 identity in 207 aa overlap)%3B etc. Belongs to the uprtase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=upp;locus_tag=Rv3309c;product=Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase);protein_id=CCP46128.1;transl_table=11
AL123456.3	EMBL	gene	3697198	3698097	.	+	.	ID=gene-Rv3310;Name=sapM;gbkey=Gene;gene=sapM;gene_biotype=protein_coding;locus_tag=Rv3310
AL123456.3	EMBL	CDS	3697198	3698097	.	+	0	ID=cds-CCP46129.1;Parent=gene-Rv3310;Dbxref=EnsemblGenomes-Gn:Rv3310,EnsemblGenomes-Tr:CCP46129,GOA:O53361,InterPro:IPR007312,InterPro:IPR017850,UniProtKB/TrEMBL:O53361,NCBI_GP:CCP46129.1;Name=CCP46129.1;Note=Rv3310%2C (MTV016.09)%2C sapM%2C len: 299 aa. Secreted acid phosphatase%2C with N-terminal sequence beginning with ASAL...%2C (see Saleh and Belisle%2C 2000). Similar to several fungal or bacterial acid phosphatases e.g. BAB50846|MLR4110 from Rhizobium loti (Mesorhizobium loti) (292 aa)%2C FASTA scores: opt: 460%2C E(): 4.8e-22%2C (38.65%25 identity in 295 aa overlap)%3B P34724|PHOA_ASPNG from Aspergillus niger (417 aa)%2C FASTA scores: opt: 172%2C E(): 0.0013%2C (29.1%25 identity in 306 aa overlap)%3B P08540|PHOX_KLULA from Kluyveromyces lactis (Yeast) (421 aa)%2C FASTA scores: opt: 170%2C E(): 0.0018%2C (27.8%25 identity in 266 aa overlap)%3B P37274|PHOA_PENCH from Penicillium chrysogenum (412 aa)%2CFASTA scores: opt: 163%2C E(): 0.0049%2C (29.05%25 identity in 303 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sapM;locus_tag=Rv3310;product=Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase);protein_id=CCP46129.1;transl_table=11
AL123456.3	EMBL	gene	3698121	3699383	.	+	.	ID=gene-Rv3311;Name=Rv3311;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3311
AL123456.3	EMBL	CDS	3698121	3699383	.	+	0	ID=cds-CCP46130.1;Parent=gene-Rv3311;Dbxref=EnsemblGenomes-Gn:Rv3311,EnsemblGenomes-Tr:CCP46130,UniProtKB/TrEMBL:O53362,NCBI_GP:CCP46130.1;Name=CCP46130.1;Note=Rv3311%2C (MTV016.10)%2C len: 420 aa. Conserved protein%2Cequivalent to Mycobacterium leprae hypothetical proteins Q9CCL8|ML0703 (423 aa)%2C FASTA scores: opt: 2185%2C E(): 5.5e-120%2C (77.55%25 identity in 423 aa overlap)%3B Q49918|L308_F2_61 (167 aa)%2C FASTA scores: opt: 929%2C E(): 3.5e-47%2C (84.4%25 identity in 167 aa overlap) (similarity at C-terminus for this one)%3B and Q49914|L308_F1_17 (166 aa)%2CFASTA scores: opt: 900%2C E(): 1.7e-45%2C (79.0%25 identity in 162 aa overlap) (similarity at N-terminus for this one)%3B Q49923|U0308N (86 aa) FASTA scores: opt: 149%2C E(): 0.052%2C(48.35%25 identity in 60 aa overlap)%3B etc. Note that the Rv3311 corresponding protein in Mycobacterium leprae is similar to products of two adjacent ORFs. Also some similarity to Q9XI61|F9L1.1 hypothetical protein from Arabidopsis thaliana (Mouse-ear cress) (523 aa)%2C FASTA scores: opt: 134%2C E(): 1.8%2C (25.1%25 identity in 203 aa overlap). Equivalent to AAK47753 from Mycobacterium tuberculosis strain CDC1551 (431 aa) but shorter 12 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3311;product=Conserved protein;protein_id=CCP46130.1;transl_table=11
AL123456.3	EMBL	gene	3699404	3700330	.	-	.	ID=gene-Rv3312c;Name=Rv3312c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3312c
AL123456.3	EMBL	CDS	3699404	3700330	.	-	0	ID=cds-CCP46131.1;Parent=gene-Rv3312c;Dbxref=EnsemblGenomes-Gn:Rv3312c,EnsemblGenomes-Tr:CCP46131,InterPro:IPR029058,UniProtKB/TrEMBL:O53363,NCBI_GP:CCP46131.1;Name=CCP46131.1;Note=Rv3312c%2C (MTV016.11)%2C len: 308 aa. Hypothetical protein%2C similar to various proteins (principally hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7 hypothetical protein from Arabidopsis thaliana (Mouse-ear cress) (326 aa)%2C FASTA scores: opt: 261%2C E(): 2.6e-09%2C(27.55%25 identity in 323 aa overlap)%3B Q9FWB6 putative alpha/beta hydrolase from Oryza sativa (Rice) (354 aa)%2CFASTA scores: opt: 241%2C E(): 4.9e-08%2C (28.9%25 identity in 301 aa overlap) (note that Q9FWB6 correspond to Q9FWB5 putative alpha/beta hydrolase (353 aa) but longer 1 aa%3B and to Q9AUW9 hypothetical protein (332 aa) but longer 22 aa)%3B Q9M382|F24B22.200 hypothetical protein from Arabidopsis thaliana (Mouse-ear cress) (342 aa)%2C FASTA scores: opt: 222%2C E(): 8e-07%2C (27.6%25 identity in 319 aa overlap)%3B Q9HWM9|PA4152 probable hydrolase from Pseudomonas aeruginosa (370 aa)%2C FASTA scores: opt: 176%2C E(): 0.00071%2C(29.2%25 identity in 209 aa overlap)%3B Q9L3R2 hydrolase from Rhizobium leguminosarum (261 aa)%2C FASTA scores: opt: 174%2CE(): 0.00071%2C (28.9%25 identity in 173 aa overlap)%3B P49323|PRXC_STRLI|CPO|CPOL non-heme chloroperoxidase from Streptomyces lividans (275 aa)%2C FASTA scores: opt: 172%2CE(): 0.001%2C (30.9%25 identity in 194 aa overlap) (similarity only at N-terminus for this one)%3B etc. Some similarity in N-terminal part to non-heme chloroperoxidases. Also similar to O05293|Rv1191|MTCI364.03 hypothetical protein from M. tuberculosis (304 aa)%2C FASTA scores: opt: 417%2C E(): 3.1e-19%2C (32.6%25 identity in 279 aa overlap) (note that Rv1191 is equivalent to AAK45485 from Mycobacterium tuberculosis strain CDC1551 but shorter 14 aa%2C and that AAK45485 is annoted Hydrolase%2C alpha/beta hydrolase family).;gbkey=CDS;locus_tag=Rv3312c;product=Conserved hypothetical protein;protein_id=CCP46131.1;transl_table=11
AL123456.3	EMBL	gene	3700705	3701016	.	-	.	ID=gene-Rv3312A;Name=Rv3312A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3312A
AL123456.3	EMBL	CDS	3700705	3701016	.	-	0	ID=cds-CCP46132.1;Parent=gene-Rv3312A;Dbxref=EnsemblGenomes-Gn:Rv3312A,EnsemblGenomes-Tr:CCP46132,GOA:P9WI87,NCBI_GP:CCP46132.1;Name=CCP46132.1;Note=Rv3312A%2C len: 103 aa. Secreted protein antigen%2Cdescribed in Corixa patent as having N-terminal sequence YYWCPGQPFDPAWGP. Equivalent to AAK47756 from Mycobacterium tuberculosis strain CDC1551 (114 aa) but shorter 11 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3312A;product=Secreted protein antigen;protein_id=CCP46132.1;transl_table=11
AL123456.3	EMBL	gene	3701087	3702184	.	-	.	ID=gene-Rv3313c;Name=add;gbkey=Gene;gene=add;gene_biotype=protein_coding;locus_tag=Rv3313c
AL123456.3	EMBL	CDS	3701087	3702184	.	-	0	ID=cds-CCP46133.1;Parent=gene-Rv3313c;Dbxref=EnsemblGenomes-Gn:Rv3313c,EnsemblGenomes-Tr:CCP46133,GOA:P63907,InterPro:IPR001365,InterPro:IPR006330,InterPro:IPR028893,NCBI_GP:CCP46133.1;Name=CCP46133.1;Note=Rv3313c%2C (MTV016.13)%2C len: 365 aa. Probable add%2Cadenosine deaminase%2C equivalent to Q9CCL9|add|ML0700 putative adenosine deaminase from Mycobacterium leprae (362 aa)%2C FASTA scores: opt: 2097%2C E(): 1.4e-127%2C (88.2%25 identity in 356 aa overlap). Also similar to many e.g. Q9AK25|2SCK8.27 from Streptomyces coelicolor (396 aa)%2CFASTA scores: opt: 1578%2C E(): 3.7e-94%2C (66.65%25 identity in 360 aa overlap)%3B Q17747|C06G3.5 from Caenorhabditis elegans (349 aa)%2C FASTA scores: opt: 435%2C E(): 1.1e-20%2C (29.6%25 identity in 348 aa overlap)%3B P22333|ADD_ECOLI|B1623 from Escherichia coli strain K12 (333 aa)%2C FASTA scores: opt: 380%2C E(): 3.7e-17%2C (29.4%25 identity in 340 aa overlap)%3B etc. Belongs to the adenosine and AMP deaminases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=add;locus_tag=Rv3313c;product=Probable adenosine deaminase Add (adenosine aminohydrolase);protein_id=CCP46133.1;transl_table=11
AL123456.3	EMBL	gene	3702184	3703467	.	-	.	ID=gene-Rv3314c;Name=deoA;gbkey=Gene;gene=deoA;gene_biotype=protein_coding;locus_tag=Rv3314c
AL123456.3	EMBL	CDS	3702184	3703467	.	-	0	ID=cds-CCP46134.1;Parent=gene-Rv3314c;Dbxref=EnsemblGenomes-Gn:Rv3314c,EnsemblGenomes-Tr:CCP46134,GOA:P9WFS1,InterPro:IPR000053,InterPro:IPR000312,InterPro:IPR013102,InterPro:IPR017459,InterPro:IPR017872,InterPro:IPR018090,NCBI_GP:CCP46134.1;Name=CCP46134.1;Note=Rv3314c%2C (MTV016.14)%2C len: 427 aa. Probable deoA%2Cthymidine phosporylase%2C highly similar to many e.g. Q9AK36|DEOA from Streptomyces coelicolor (427 aa)%2C FASTA scores: opt: 1668%2C E(): 3.2e-90%2C (62.35%25 identity in 425 aa overlap)%3B Q9CFM5|PDP from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (430 aa)%2C FASTA scores: opt: 1031%2C E(): 5.5e-53%2C (46.45%25 identity in 392 aa overlap)%3B P19971|TYPH_HUMAN|ECGF1 from Homo sapiens (Human) (482 aa)%2CFASTA scores: opt: 957%2C E(): 1.3e-48%2C (44.45%25 identity in 441 aa overlap)%3B P07650|TYPH_ECOLI|DEOA|TPP|TTG|B4382 from Escherichia coli strain K12 (440 aa)%2C FASTA scores: opt: 847%2C E(): 3.2e-42%2C (41.55%25 identity in 438 aa overlap)%3B etc. Contains PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. Belongs to the thymidine/pyrimidine-nucleoside phosphorylases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=deoA;inference=protein motif:PROSITE:PS00647;locus_tag=Rv3314c;product=Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase);protein_id=CCP46134.1;transl_table=11
AL123456.3	EMBL	gene	3703464	3703865	.	-	.	ID=gene-Rv3315c;Name=cdd;gbkey=Gene;gene=cdd;gene_biotype=protein_coding;locus_tag=Rv3315c
AL123456.3	EMBL	CDS	3703464	3703865	.	-	0	ID=cds-CCP46135.1;Parent=gene-Rv3315c;Dbxref=EnsemblGenomes-Gn:Rv3315c,EnsemblGenomes-Tr:CCP46135,GOA:P9WPH3,InterPro:IPR002125,InterPro:IPR016193,PDB:3IJF,NCBI_GP:CCP46135.1;Name=CCP46135.1;Note=Rv3315c%2C (MTV016.15c)%2C len: 133 aa. Probable cdd%2Ccytidine deaminase%2C equivalent to Q9CBD3|CDD|ML2174 cytidine deaminase from Mycobacterium leprae (134 aa)%2CFASTA scores: opt: 516%2C E(): 5.8e-28%2C (56.8%25 identity in 132 aa overlap). Also highly similar to many e.g. Q9AK37|2SCK8.15 from Streptomyces coelicolor (130 aa)%2CFASTA scores: opt: 523%2C E(): 1.9e-28%2C (60.0%25 identity in 130 aa overlap)%3B Q9KD53|CDD|BH1366 from Bacillus halodurans (132 aa)%2C FASTA scores: opt: 305%2C E(): 9.2e-14%2C (41.55%25 identity in 130 aa overlap)%3B P56389|CDD_MOUSE|CDA|CDD from Mus musculus (Mouse) (146 aa)%2C FASTA scores: opt: 287%2C E(): 1.6e-12%2C (40.3%25 identity in 124 aa overlap)%3B P19079|CDD_BACSU (136 aa)%2C FASTA scores: opt: 270%2C E(): 2.1e-11%2C (28.6%25 identity in 127 aa overlap)%3B etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. Belongs to the cytidine and deoxycytidylate deaminases family. Cofactor: zinc (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cdd;inference=protein motif:PROSITE:PS00903;locus_tag=Rv3315c;product=Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase);protein_id=CCP46135.1;transl_table=11
AL123456.3	EMBL	gene	3704102	3704440	.	+	.	ID=gene-Rv3316;Name=sdhC;gbkey=Gene;gene=sdhC;gene_biotype=protein_coding;locus_tag=Rv3316
AL123456.3	EMBL	CDS	3704102	3704440	.	+	0	ID=cds-CCP46136.1;Parent=gene-Rv3316;Dbxref=EnsemblGenomes-Gn:Rv3316,EnsemblGenomes-Tr:CCP46136,GOA:O53368,InterPro:IPR000701,InterPro:IPR014314,UniProtKB/TrEMBL:O53368,NCBI_GP:CCP46136.1;Name=CCP46136.1;Note=Rv3316%2C (MTV016.16)%2C len: 112 aa. Probable sdhC%2Ccytochrome B-556 of succinate dehydrogenase SdhC subunit %2Ctransmembrane protein%2C equivalent (but shorter 35 aa) to Q9CCM0|SDHC|ML0699 putative succinate dehydrogenase cytochrome B-556 subunit from Mycobacterium leprae (153 aa)%2C FASTA scores: opt: 692%2C E(): 1.2e-39%2C (88.4%25 identity in 112 aa overlap). Also similar to others e.g. Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126 aa)%2CFASTA scores: opt: 484%2C E(): 8.3e-26%2C (65.65%25 identity in 99 aa overlap)%3B Q9RVR8|DR0954 from Deinococcus radiodurans (118 aa)%2C FASTA scores: opt: 195%2C E(): 1.7e-06%2C (36.8%25 identity in 87 aa overlap)%3B Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium sp. strain NRC-1 (130 aa)%2C FASTA scores: opt: 192%2C E(): 2.9e-06%2C (37.85%25 identity in 74 aa overlap)%3B P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis (Natronobacterium pharaonis) (130 aa)%2C FASTA scores: opt: 183%2C E(): 1.1e-05%2C (35.15%25 identity in 74 aa overlap)%3B etc. Part of an enzyme complex containing four subunits: a flavoprotein%2C an iron-sulfur%2C cytochrome B-556%2C and an hydrophobic anchor protein. Belongs to the cytochrome B560 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sdhC;locus_tag=Rv3316;product=Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP46136.1;transl_table=11
AL123456.3	EMBL	gene	3704437	3704871	.	+	.	ID=gene-Rv3317;Name=sdhD;gbkey=Gene;gene=sdhD;gene_biotype=protein_coding;locus_tag=Rv3317
AL123456.3	EMBL	CDS	3704437	3704871	.	+	0	ID=cds-CCP46137.1;Parent=gene-Rv3317;Dbxref=EnsemblGenomes-Gn:Rv3317,EnsemblGenomes-Tr:CCP46137,GOA:O53369,InterPro:IPR000701,UniProtKB/TrEMBL:O53369,NCBI_GP:CCP46137.1;Name=CCP46137.1;Note=Rv3317%2C (MTV016.17)%2C len: 144 aa. Probable sdhD%2Cmembrane anchor of succinate dehydrogenase SdhD subunit %2Cequivalent (but shorter 19 aa) to Q49915|SDHD|ML0698|L308_F1_25 putative succinate dehydrogenase hydrophobic membrane anchor protein from Mycobacterium leprae (163 aa)%2C FASTA scores: opt: 878%2C E(): 1.9e-51%2C (85.2%25 identity in 142 aa overlap). Also similar to others e.g. Q9KZ89|SC5G8.25c from Streptomyces coelicolor (160 aa)%2C FASTA scores: opt: 553%2C E(): 6.6e-30%2C(58.85%25 identity in 141 aa overlap)%3B Q9RVR9|DR0953 from Deinococcus radiodurans (125 aa)%2C FASTA scores: opt: 251%2CE(): 5.5e-10%2C (37.15%25 identity in 113 aa overlap)%3B O29573|DHSD_ARCFU|SDHD|AF0684 from Archaeoglobus fulgidus (117 aa)%2C FASTA scores: opt: 160%2C E(): 0.00056%2C (25.95%25 identity in 108 aa overlap)%3B etc. Part of an enzyme complex containing four subunits: a flavoprotein%2C an iron-sulfur%2Ccytochrome B-556%2C and an hydrophobic anchor protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sdhD;locus_tag=Rv3317;product=Probable succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP46137.1;transl_table=11
AL123456.3	EMBL	repeat_region	3704895	3705004	.	-	.	ID=id-AL123456.3:3704895..3705004;Note=110 bp Mycobacterial Interspersed Repetitive Unit%2CClass III;gbkey=repeat_region
AL123456.3	EMBL	gene	3705000	3706772	.	+	.	ID=gene-Rv3318;Name=sdhA;gbkey=Gene;gene=sdhA;gene_biotype=protein_coding;locus_tag=Rv3318
AL123456.3	EMBL	CDS	3705000	3706772	.	+	0	ID=cds-CCP46138.1;Parent=gene-Rv3318;Dbxref=EnsemblGenomes-Gn:Rv3318,EnsemblGenomes-Tr:CCP46138,GOA:O53370,InterPro:IPR003952,InterPro:IPR003953,InterPro:IPR011281,InterPro:IPR014006,InterPro:IPR015939,InterPro:IPR027477,UniProtKB/TrEMBL:O53370,NCBI_GP:CCP46138.1;Name=CCP46138.1;Note=Rv3318%2C (MTV016.18)%2C len: 590 aa. Probable sdhA%2Cflavoprotein of succinate dehydrogenase SdhA subunit%2Cequivalent to Q9CCM1|SDHA|ML0697 succinate dehydrogenase flavoprotein subunit from Mycobacterium leprae (584 aa)%2CFASTA scores: opt: 3657%2C E(): 1.2e-217%2C (92.55%25 identity in 590 aa overlap). Also highly similar to others e.g. Q9KZ90|DHSA from Streptomyces coelicolor (584 aa)%2C FASTA scores: opt: 2813%2C E(): 1.1e-165%2C (70.5%25 identity in 586 aa overlap)%3B Q9RVS0|DR0952 from Deinococcus radiodurans (583 aa)%2C FASTA scores: opt: 2203%2C E(): 4.1e-128%2C (57.35%25 identity in 593 aa overlap)%3B P31038|DHSA_RICPR|SDHA|RP128 from Rickettsia prowazekii (596 aa)%2C FASTA scores: opt: 1892%2C E(): 5.8e-109%2C (50.0%25 identity in 588 aa overlap)%3B P10444|DHSA_ECOLI|SDHA|B0723|Z0877|ECS0748 from Escherichia coli strains K12 and O157:H7 (588 aa)%2C FASTA scores: opt: 1844%2C E(): 5.2e-106%2C (48.75%25 identity in 591 aa overlap)%3B etc. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. Cofactor: FAD. Similar to the flavoprotein subunits of other species succinate dehydrogenase and of fumarate reductase. Part of an enzyme complex containing four subunits: a flavoprotein%2C an iron-sulfur%2C cytochrome B-556%2C and an hydrophobic anchor protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sdhA;inference=protein motif:PROSITE:PS00504;locus_tag=Rv3318;product=Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP46138.1;transl_table=11
AL123456.3	EMBL	gene	3706772	3707563	.	+	.	ID=gene-Rv3319;Name=sdhB;gbkey=Gene;gene=sdhB;gene_biotype=protein_coding;locus_tag=Rv3319
AL123456.3	EMBL	CDS	3706772	3707563	.	+	0	ID=cds-CCP46139.1;Parent=gene-Rv3319;Dbxref=EnsemblGenomes-Gn:Rv3319,EnsemblGenomes-Tr:CCP46139,GOA:O53371,InterPro:IPR001041,InterPro:IPR004489,InterPro:IPR009051,InterPro:IPR012675,InterPro:IPR017896,InterPro:IPR017900,InterPro:IPR025192,UniProtKB/TrEMBL:O53371,NCBI_GP:CCP46139.1;Name=CCP46139.1;Note=Rv3319%2C (MTV016.19)%2C len: 263 aa. Probable sdhB%2Ciron-sulphur protein succinate dehydrogenase SdhB subunit %2Cequivalent to Q49916|SDHB|ML0696|L308_F1_28 succinate dehydrogenase iron-sulfur protein from Mycobacterium leprae (264 aa)%2C FASTA scores: opt: 1678%2C E(): 4.7e-99%2C (89.8%25 identity in 264 aa overlap). Also highly similar to other e.g. Q9KZ91|DHSB from Streptomyces coelicolor (257 aa)%2CFASTA scores: opt: 1125%2C E(): 4.6e-64%2C (64.1%25 identity in 262 aa overlap)%3B Q9RVS1|DR0951 from Deinococcus radiodurans (264 aa)%2C FASTA scores: opt: 1014%2C E(): 5e-57%2C (57.25%25 identity in 255 aa overlap)%3B Q9PEF5|XF1073 from Xylella fastidiosa (261 aa)%2C FASTA scores: opt: 681%2C E(): 5.8e-36%2C(45.1%25 identity in 244 aa overlap)%3B P07014|DHSB_ECOLI|SDHB|B0724 from Escherichia coli strain K12 (238 aa)%2C FASTA scores: opt: 657%2C E(): 1.8e-34%2C (43.75%25 identity in 240 aa overlap)%3B etc. Contains PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature. Cofactor: binds three different iron-sulfur clusters: a 2FE-2S%2C a 3FE-4S and a 4FE-4S. The iron-sulfur centers are similar to those of 'plant-type' 2FE-2S and 'bacterial-type' 4FE-4S ferredoxins. Part of an enzyme complex containing four subunits: a flavoprotein%2C an iron-sulfur%2C cytochrome B-556%2C and an hydrophobic anchor protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sdhB;inference=protein motif:PROSITE:PS00198;locus_tag=Rv3319;product=Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);protein_id=CCP46139.1;transl_table=11
AL123456.3	EMBL	gene	3707642	3708070	.	-	.	ID=gene-Rv3320c;Name=vapC44;gbkey=Gene;gene=vapC44;gene_biotype=protein_coding;locus_tag=Rv3320c
AL123456.3	EMBL	CDS	3707642	3708070	.	-	0	ID=cds-CCP46140.1;Parent=gene-Rv3320c;Dbxref=EnsemblGenomes-Gn:Rv3320c,EnsemblGenomes-Tr:CCP46140,GOA:P9WF53,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP46140.1;Name=CCP46140.1;Note=Rv3320c%2C (MTV016.20c)%2C len: 142 aa. Possible vapC44%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv0300%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to several others in Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P95023|Rv2530c|MTCY159.26 (139 aa)%2C FASTA scores: opt: 292%2C E(): 4.8e-14%2C (41.5%25 identity in 135 aa overlap)%3B O53219|Rv2494|MTV008.50 (141 aa)%2C FASTA scores: opt: 287%2C E(): 1.1e-13%2C (41.6%25 identity in 125 aa overlap)%3B O07760|Rv0617|MTCY19H5.04c (133 aa)%2C FASTA scores: opt: 252%2C E(): 3.3e-11%2C (37.8%25 identity in 127 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC44;locus_tag=Rv3320c;product=Possible toxin VapC44. Contains PIN domain.;protein_id=CCP46140.1;transl_table=11
AL123456.3	EMBL	gene	3708074	3708316	.	-	.	ID=gene-Rv3321c;Name=vapB44;gbkey=Gene;gene=vapB44;gene_biotype=protein_coding;locus_tag=Rv3321c
AL123456.3	EMBL	CDS	3708074	3708316	.	-	0	ID=cds-CCP46141.1;Parent=gene-Rv3321c;Dbxref=EnsemblGenomes-Gn:Rv3321c,EnsemblGenomes-Tr:CCP46141,GOA:P9WJ17,InterPro:IPR002145,NCBI_GP:CCP46141.1;Name=CCP46141.1;Note=Rv3321c%2C (MTV016.21c)%2C len: 80 aa. Possible vapB44%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv0299%2Csee Arcus et al. 2005. Similar to several others in Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. AAK48167|MT3800 DNA-binding protein (COPG family) from strain CDC1551 (74 aa)%2C FASTA scores: opt: 142%2C E(): 0.0016%2C (48.85%25 identity in 43 aa overlap)%3B AAK46916|MT2606 hypothetical 8.0 KDA protein from strain CDC1551 (74 aa)%2CFASTA scores: opt: 139%2C E(): 0.0026%2C (37.2%25 identity in 78 aa overlap)%3B O50456|Rv1241|MTV006.13 hypothetical 9.9 KDA protein from strain H37Rv (86 aa)%2C FASTA scores: opt: 134%2CE(): 0.0066%2C (39.0%25 identity in 82 aa overlap)%3B etc.;gbkey=CDS;gene=vapB44;locus_tag=Rv3321c;product=Possible antitoxin VapB44;protein_id=CCP46141.1;transl_table=11
AL123456.3	EMBL	gene	3708438	3709052	.	-	.	ID=gene-Rv3322c;Name=Rv3322c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3322c
AL123456.3	EMBL	CDS	3708438	3709052	.	-	0	ID=cds-CCP46142.1;Parent=gene-Rv3322c;Dbxref=EnsemblGenomes-Gn:Rv3322c,EnsemblGenomes-Tr:CCP46142,GOA:L7N687,InterPro:IPR029063,UniProtKB/TrEMBL:L7N687,NCBI_GP:CCP46142.1;Name=CCP46142.1;Note=Rv3322c%2C (MTV016.22c)%2C len: 204 aa. Conserved hypothetical protein%2C showing weak similarity to proteins including several methyltransferases e.g. Q9X9V1|ORF8 putative methyltransferase from Streptomyces coelicolor (208 aa)%2C FASTA scores: opt: 193%2C E(): 1e-05%2C (36.35%25 identity in 132 aa overlap)%3B and Q9XA90|SCF43A.25c putative methyltransferase from Streptomyces coelicolor (215 aa)%2CFASTA scores: opt: 161%2C E(): 0.0014%2C (32.05%25 identity in 131 aa overlap)%3B P74712|SLR1183 hypothetical 21.3 KDA protein from Synechocystis sp. strain PCC 6803 (194 aa)%2CFASTA scores: opt: 155%2C E(): 0.0032%2C (27.35%25 identity in 150 aa overlap)%3B Q9ABW8|CC0102 rRNA methyltransferase RSMB from Caulobacter crescentus (429 aa)%2C FASTA scores: opt: 148%2C E(): 0.018%2C (31.5%25 identity in 162 aa overlap)%3B etc. Also highly similar to O05796|Rv3120|MTCY164.30 hypothetical 21.8 KDA protein from Mycobacterium tuberculosis (200 aa)%2C FASTA scores: opt: 691%2C E(): 1.2e-38%2C (56.5%25 identity in 200 aa overlap)%3B and shows weak similarity to O69667|Rv3699|MTV025.047 putative methyltransferase from Mycobacterium tuberculosis (233 aa)%2CFASTA scores: opt: 155%2C E(): 0.0037%2C (29.15%25 identity in 168 aa overlap).;gbkey=CDS;locus_tag=Rv3322c;product=Possible methyltransferase;protein_id=CCP46142.1;transl_table=11
AL123456.3	EMBL	gene	3709049	3709714	.	-	.	ID=gene-Rv3323c;Name=moaX;gbkey=Gene;gene=moaX;gene_biotype=protein_coding;locus_tag=Rv3323c
AL123456.3	EMBL	CDS	3709049	3709714	.	-	0	ID=cds-CCP46143.1;Parent=gene-Rv3323c;Dbxref=EnsemblGenomes-Gn:Rv3323c,EnsemblGenomes-Tr:CCP46143,GOA:Q6MWY3,InterPro:IPR003448,InterPro:IPR003749,InterPro:IPR010034,InterPro:IPR012675,InterPro:IPR016155,UniProtKB/TrEMBL:Q6MWY3,NCBI_GP:CCP46143.1;Name=CCP46143.1;Note=Rv3323c%2C (MTV016.23c)%2C len: 221 aa. Probable moaX%2CMoaD-MoaE fusion protein%2C similar (whole or partial) to several MoaD and MoaE proteins e.g. Q9RR88|DR2607 molybdenum cofactor biosynthesis protein D/E from Deinococcus radiodurans (229 aa)%2C FASTA scores: opt: 407%2CE(): 1.8e-18%2C (32.75%25 identity in 223 aa overlap)%3B Q9K8I7|MOAE|BH3019 molybdopterin converting factor (subunit 2) from Bacillus halodurans (156 aa)%2C FASTA scores: opt: 375%2C E(): 1.3e-16%2C (41.65%25 identity in 132 aa overlap)%3B O31705|MOAE molybdopterin converting factor (subunit 2) from Bacillus subtilis (157 aa)%2C FASTA scores: opt: 368%2CE(): 3.6e-16%2C (41.65%25 identity in 132 aa overlap)%3B etc. C-terminus highly similar to O05795|MOAE_MYCTU|Rv3119|MT3201|MTCY164.29|MOAE1 putative molybdenum cofactor biosynthesis protein E from Mycobacterium tuberculosis (147 aa)%2C FASTA scores: opt: 733%2C E(): 5.4e-39%2C (76.2%25 identity in 143 aa overlap)%3B and N-terminus highly similar to O05789|MOAD1|Rv3112|MTCY164.22 putative molybdenum cofactor biosynthesis protein D from Mycobacterium tuberculosis (83 aa)%2C FASTA scores: opt: 333%2CE(): 3.2e-14%2C (65.05%25 identity in 83 aa overlap).;gbkey=CDS;gene=moaX;locus_tag=Rv3323c;product=Probable MoaD-MoaE fusion protein MoaX;protein_id=CCP46143.1;transl_table=11
AL123456.3	EMBL	gene	3709715	3710248	.	-	.	ID=gene-Rv3324c;Name=moaC3;gbkey=Gene;gene=moaC3;gene_biotype=protein_coding;locus_tag=Rv3324c
AL123456.3	EMBL	CDS	3709715	3710248	.	-	0	ID=cds-CCP46144.1;Parent=gene-Rv3324c;Dbxref=EnsemblGenomes-Gn:Rv3324c,EnsemblGenomes-Tr:CCP46144,GOA:P9WJR5,InterPro:IPR002820,InterPro:IPR023045,InterPro:IPR023046,NCBI_GP:CCP46144.1;Name=CCP46144.1;Note=Rv3324c%2C (MTV016.24c)%2C len: 177 aa. Probable moaC3%2Cmolybdopterin cofactor biosynthesis protein%2C highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa)%2C FASTA scores: opt: 567%2C E(): 7.5e-30%2C(58.35%25 identity in 156 aa overlap)%3B Q9RKA8|MOAC from Streptomyces coelicolor (170 aa)%2C FASTA scores: opt: 553%2CE(): 6.3e-29%2C (58.25%25 identity in 158 aa overlap)%3B P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa)%2C FASTA scores: opt: 516%2C E(): 1.5e-26%2C (55.95%25 identity in 159 aa overlap)%3B etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 putative molybdenum cofactor biosynthesis protein C from Mycobacterium tuberculosis (170 aa)%2C FASTA scores: opt: 734%2C E(): 1.3e-40%2C (71.8%25 identity in 163 aa overlap)%3B and Rv0864|MOAC2|MTV043.57 putative molybdenum cofactor biosynthesis protein (167 aa).;gbkey=CDS;gene=moaC3;locus_tag=Rv3324c;product=Probable molybdenum cofactor biosynthesis protein C 3 MoaC3;protein_id=CCP46144.1;transl_table=11
AL123456.3	EMBL	pseudogene	3710245	3710379	.	-	.	ID=gene-Rv3324A;Name=Rv3324A;gbkey=Gene;gene_biotype=pseudogene;locus_tag=Rv3324A;pseudo=true;pseudogene=unknown
AL123456.3	EMBL	CDS	3710245	3710379	.	-	0	ID=cds-Rv3324A;Parent=gene-Rv3324A;Note=Rv3324A%2C len: 44 aa. Probable pseudogene moaB3%2Cfragment of pterin-4-alpha-carbinolamine dehydratase%2Cequivalent to C-terminus of MT3426|Q8VJ32 pterin-4-alpha-carbinolamine dehydratase from Mycobacterium tuberculosis strain CDC1551 (124 aa)%2C FASTA scores: opt: 309%2C E(): 1.1e-20%2C (100.000%25 identity in 44 aa overlap)%2Cand C-terminus of Mb3354c|moaB3 probable pterin-4-alpha-carbinolamine dehydratase from Mycobacterium bovis (124 aa). Note that a deletion of DNA (RvD5 region) in Mycobacterium tuberculosis strain H37Rv resulted in a truncated CDS comparatively to Mycobacterium bovis or Mycobacterium tuberculosis strain CDC1551 genomes (see citations below).;gbkey=CDS;locus_tag=Rv3324A;product=Probable fragment of pterin-4-alpha-carbinolamine dehydratase MOAB3 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD);pseudo=true;pseudogene=unknown;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3710382	3711736	.	+	.	ID=id-AL123456.3:3710382..3711736;Note=IS6110-14%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-14
AL123456.3	EMBL	repeat_region	3710382	3710409	.	+	.	ID=id-AL123456.3:3710382..3710409;Note=28 bp inverted repeat at left end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	3710433	3710759	.	+	.	ID=gene-Rv3325;Name=Rv3325;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3325
AL123456.3	EMBL	CDS	3710433	3710759	.	+	0	ID=cds-CCP46146.1;Parent=gene-Rv3325;Dbxref=EnsemblGenomes-Gn:Rv3325,EnsemblGenomes-Tr:CCP46146,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP46146.1;Name=CCP46146.1;Note=Rv3325%2C (MTV016.25)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3325 and Rv3326%2Cthe sequence UUUUAAAG (directly upstream of Rv3326) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Belongs to the transposase family 8.;gbkey=CDS;locus_tag=Rv3325;product=Probable transposase for insertion sequence element IS6110 (fragment);protein_id=CCP46146.1;transl_table=11
AL123456.3	EMBL	gene	3710708	3711694	.	+	.	ID=gene-Rv3326;Name=Rv3326;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3326;partial=true;start_range=.,3710708
AL123456.3	EMBL	CDS	3710708	3711694	.	+	0	ID=cds-CCP46147.1;Parent=gene-Rv3326;Dbxref=EnsemblGenomes-Gn:Rv3326,EnsemblGenomes-Tr:CCP46147,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP46147.1;Name=CCP46147.1;Note=Rv3326%2C (MTV016.26)%2C len: 328 aa. Probable transposase for insertion element IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3325 and Rv3326%2Cthe sequence UUUUAAAG (directly upstream of Rv3326) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 16 aa).;gbkey=CDS;locus_tag=Rv3326;partial=true;product=Probable transposase;protein_id=CCP46147.1;start_range=.,3710708;transl_table=11
AL123456.3	EMBL	repeat_region	3711709	3711736	.	-	.	ID=id-AL123456.3:3711709..3711736;Note=28 bp inverted repeat at right end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	mobile_genetic_element	3711737	3712822	.	+	.	ID=id-AL123456.3:3711737..3712822;Note=IS1547-2%2C len: 1086 nt. Region corresponding to Insertion sequence IS1547%2C positions 1982 3067 in EM_NEW:MTY13470.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1547-2
AL123456.3	EMBL	gene	3711749	3713461	.	+	.	ID=gene-Rv3327;Name=Rv3327;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3327
AL123456.3	EMBL	CDS	3711749	3713461	.	+	0	ID=cds-CCP46148.1;Parent=gene-Rv3327;Dbxref=EnsemblGenomes-Gn:Rv3327,EnsemblGenomes-Tr:CCP46148,GOA:O53377,InterPro:IPR002525,InterPro:IPR003346,InterPro:IPR029032,UniProtKB/TrEMBL:O53377,NCBI_GP:CCP46148.1;Name=CCP46148.1;Note=Rv3327%2C (MTV016.27)%2C len: 570 aa. Probable fusion protein. Indeed%2C N-terminal part corresponds to entire O07269 transposase of IS1547 (383 aa)%2C and C-terminal part identical to MTCI249B.03c (210 aa). N-terminal part is identical to MTV042_7 (188 aa)%3B C-terminal part (aa 378-570) is similar to hypothetical 20.5 kDa protein from Escherichia coli P76222|YNJA_ECOLI (182 aa)%2C FASTA scores: opt: 292%2C E(): 5.3e-11%2C (32.6%25 identity in 181 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3327;product=Probable transposase fusion protein;protein_id=CCP46148.1;transl_table=11
AL123456.3	EMBL	gene	3713394	3714332	.	-	.	ID=gene-Rv3328c;Name=sigJ;gbkey=Gene;gene=sigJ;gene_biotype=protein_coding;locus_tag=Rv3328c
AL123456.3	EMBL	CDS	3713394	3714332	.	-	0	ID=cds-CCP46149.1;Parent=gene-Rv3328c;Dbxref=EnsemblGenomes-Gn:Rv3328c,EnsemblGenomes-Tr:CCP46149,GOA:L0TCG5,InterPro:IPR007627,InterPro:IPR009959,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,NCBI_GP:CCP46149.1;Name=CCP46149.1;Note=Rv3328c%2C (MTV016.28c)%2C len: 312 aa. Probable sigJ%2Calternative RNA polymerase sigma factor (see citations below)%2C highly similar to many e.g. Q9K3H7|2SCG18.10c from Streptomyces coelicolor (295 aa)%2C FASTA scores: opt: 642%2CE(): 7.3e-31%2C (42.8%25 identity in 292 aa overlap)%3B Q9A3D8|CC3266 from Caulobacter crescentus (291 aa)%2C FASTA scores: opt: 607%2C E(): 8.4e-29%2C (39.8%25 identity in 294 aa overlap)%3B Q9RD74|SCF43.14c from Streptomyces coelicolor (324 aa)%2C FASTA scores: opt: 555%2C E(): 1.1e-25%2C (41.1%25 identity in 297 aa overlap)%3B etc. Similar also to U00022_20 from Mycobacterium leprae%3B and MTCI28_22 and MSU87307_1. Also similar to O50445|SIGI|Rv1189|MTV005.25|MTCI364.01 putative RNA polymerase sigma factor from Mycobacterium tuberculosis (290 aa)%2C FASTA scores: opt: 426%2C E(): 4.2e-18%2C (32.65%25 identity in 294 aa overlap). Equivalent to AAK47774 from Mycobacterium tuberculosis strain CDC1551 (282 aa) but longer 30 aa. Contains probable helix-turn-helix motif at aa 129-150 (Score 1126%2C +3.02 SD). Belongs to the sigma-70 factor family%2C ECF subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigJ;locus_tag=Rv3328c;product=Probable alternative RNA polymerase sigma factor (fragment) SigJ;protein_id=CCP46149.1;transl_table=11
AL123456.3	EMBL	gene	3714392	3715708	.	+	.	ID=gene-Rv3329;Name=Rv3329;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3329
AL123456.3	EMBL	CDS	3714392	3715708	.	+	0	ID=cds-CCP46150.1;Parent=gene-Rv3329;Dbxref=EnsemblGenomes-Gn:Rv3329,EnsemblGenomes-Tr:CCP46150,GOA:O53379,InterPro:IPR005814,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:O53379,NCBI_GP:CCP46150.1;Name=CCP46150.1;Note=Rv3329%2C (MTV016.29)%2C len: 438 aa (start uncertain). Probable aminotransferase%2C similar to many e.g. O86744|SC6A9.12 from Streptomyces coelicolor (457 aa)%2CFASTA scores: opt: 2120%2C E(): 5.1e-125%2C (70.1%25 identity in 438 aa overlap)%3B Q9I6J2|PA0299 from Pseudomonas aeruginosa (456 aa)%2C FASTA scores: opt: 983%2C E(): 5.7e-54%2C (38.1%25 identity in 425 aa overlap)%3B Q53196|Y4UB_RHISN from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (467 aa)%2CFASTA scores: opt: 971%2C E(): 3.3e-53%2C (39.25%25 identity in 438 aa overlap)%3B P33189|YHXA_BACSU from Bacillus subtilis (450 aa)%2C FASTA scores: opt: 933%2C E(): 7.5e-51%2C (40.25%25 identity in 435 aa overlap)%3B etc. Equivalent to AAK47775 from Mycobacterium tuberculosis strain CDC1551 (466 aa) but shorter 28 aa. Cofactor: pyridoxal phosphate. Could belong to class-III of pyridoxal-phosphate-dependent aminotransferases.;gbkey=CDS;locus_tag=Rv3329;product=Probable aminotransferase;protein_id=CCP46150.1;transl_table=11
AL123456.3	EMBL	gene	3715777	3716994	.	+	.	ID=gene-Rv3330;Name=dacB1;gbkey=Gene;gene=dacB1;gene_biotype=protein_coding;locus_tag=Rv3330
AL123456.3	EMBL	CDS	3715777	3716994	.	+	0	ID=cds-CCP46151.1;Parent=gene-Rv3330;Dbxref=EnsemblGenomes-Gn:Rv3330,EnsemblGenomes-Tr:CCP46151,GOA:O53380,InterPro:IPR001967,InterPro:IPR012338,InterPro:IPR018044,UniProtKB/TrEMBL:O53380,NCBI_GP:CCP46151.1;Name=CCP46151.1;Note=Rv3330%2C (MTV016.30)%2C len: 405 aa. Probable dacB1%2CD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein)%2C equivalent to Mycobacterium leprae proteins Q9CCM2|ML0691 putative D-alanyl-D-alanine carboxypeptidase (411 aa)%2C FASTA scores: opt: 2066%2C E(): 2.5e-102%2C (77.15%25 identity in 416 aa overlap)%3B Q49917|L308_F1_36 (228 aa)%2CFASTA scores: opt: 1241%2C E(): 7.9e-59%2C (78.9%25 identity in 232 aa overlap) (note that this protein corresponds to C-terminal part of the putative protein encoded by Rv3330%2Caa 174-405)%3B and Q49921|PBPC (182 aa)%2C FASTA scores: opt: 736%2C E(): 3.7e-32%2C (73.95%25 identity in 169 aa overlap) (note that this protein corresponds to N-terminal part of the putative protein encoded by Rv3330%2C aa 1-158)%3B note L308_F1_36 (228 aa) and PBPC (182 aa) are two consecutive Mycobacterium leprae ORFs. Also similar to others e.g. Q9FC34|SC4G1.16c putative D-alanyl-D-alanine carboxypeptidase from Streptomyces coelicolor (413 aa)%2CFASTA scores: opt: 572%2C E(): 3.4e-23%2C (33.75%25 identity in 382 aa overlap)%3B P35150|DACB_BACSU penicillin-binding protein 5* precursor (D-alanyl-D-alanine carboxypeptidase) from Bacillus subtilis (382 aa)%2C FASTA scores: opt: 422%2CE(): 2.8e-15%2C (31.3%25 identity in 249 aa overlap)%3B Q9K8X5|DACB|BH2877 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) from Bacillus halodurans (395 aa)%2C FASTA scores: opt: 421%2C E(): 3.2e-15%2C (31.95%25 identity in 241 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis Q10828|Rv2911|MTCY274.43 probable penicillin-binding protein (belongs to peptidase family S11%3B also known as the D-alanyl-D-alanine carboxypeptidase 1 family) (291 aa)%2C FASTA scores: opt: 746%2C E(): 1.6e-32%2C(47.0%25 identity in 266 aa overlap). Has hydrophobic stretches at both N- and C-termini. Certainly membrane-bound protein. Belongs to peptidase family S11%3B also known as the D-alanyl-D-alanine carboxypeptidase 1 family. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dacB1;locus_tag=Rv3330;product=Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase);protein_id=CCP46151.1;transl_table=11
AL123456.3	EMBL	gene	3717090	3718598	.	+	.	ID=gene-Rv3331;Name=sugI;gbkey=Gene;gene=sugI;gene_biotype=protein_coding;locus_tag=Rv3331
AL123456.3	EMBL	CDS	3717090	3718598	.	+	0	ID=cds-CCP46152.1;Parent=gene-Rv3331;Dbxref=EnsemblGenomes-Gn:Rv3331,EnsemblGenomes-Tr:CCP46152,GOA:L0TDU1,InterPro:IPR003663,InterPro:IPR005828,InterPro:IPR005829,InterPro:IPR016196,InterPro:IPR020846,UniProtKB/TrEMBL:L0TDU1,NCBI_GP:CCP46152.1;Name=CCP46152.1;Note=Rv3331%2C (MTV016.31)%2C len: 502 aa (start uncertain). Probable sugI%2C sugar-transport integral membrane protein%2Cpossibly member of major facilitator superfamily (MFS)%2Csimilar to several transporters e.g. P37021|GALP_ECOLI|B2943 galactose-proton symporter (galactose transporter) from Escherichia coli strain K12 (464 aa)%2C FASTA scores: opt: 818%2C E(): 1.8e-39%2C (31.85%25 identity in 446 aa overlap)%3B P96742|YWTG metabolite-transport-related protein from Bacillus subtilis (457 aa)%2C FASTA scores: opt: 810%2C E(): 5e-39%2C (33.2%25 identity in 428 aa overlap)%3B AAG58074|GALP (alias BAB37242|ECS3819) galactose-proton symport of transport system from Escherichia coli strain O157:H7 EDL933 (464 aa)%2C FASTA scores: opt: 810%2C E(): 5.1e-39%2C (32.2%25 identity in 432 aa overlap)%3B P46333|CSBC_BACSU|SS92BR probable metabolite transport protein from Bacillus subtilis (461 aa)%2C FASTA scores: opt: 792%2C E(): 5.4e-38%2C (33.7%25 identity in 442 aa overlap)%3B etc. Equivalent to AAK47777|MT343 from Mycobacterium tuberculosis strain CDC1551 (500 aa) but with some divergence between residues 229 and 254. Contains PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2. Belongs to the sugar transporter family.;gbkey=CDS;gene=sugI;inference=protein motif:PROSITE:PS00217;locus_tag=Rv3331;product=Probable sugar-transport integral membrane protein SugI;protein_id=CCP46152.1;transl_table=11
AL123456.3	EMBL	gene	3718595	3719746	.	+	.	ID=gene-Rv3332;Name=nagA;gbkey=Gene;gene=nagA;gene_biotype=protein_coding;locus_tag=Rv3332
AL123456.3	EMBL	CDS	3718595	3719746	.	+	0	ID=cds-CCP46153.1;Parent=gene-Rv3332;Dbxref=EnsemblGenomes-Gn:Rv3332,EnsemblGenomes-Tr:CCP46153,GOA:O53382,InterPro:IPR003764,InterPro:IPR006680,InterPro:IPR011059,UniProtKB/TrEMBL:O53382,NCBI_GP:CCP46153.1;Name=CCP46153.1;Note=Rv3332%2C (MTV016.32)%2C len: 383 aa. Probable nagA%2CN-acetylglucosamine-6-phosphate deacetylase%2C similar to many e.g. Q9KXV7|SCD95A.17c putative deacetylase from Streptomyces coelicolor (381 aa)%2C FASTA scores: opt: 1090%2CE(): 1.6e-55%2C (47.8%25 identity in 385 aa overlap)%3B Q9PDB4|XF1465 N-acetylglucosamine-6-phosphate deacetylase from Xylella fastidiosa (386 aa)%2C FASTA scores: opt: 667%2CE(): 3.5e-31%2C (38.3%25 identity in 394 aa overlap)%3B Q9AAZ9|CC0443 N-acetylglucosamine-6-phosphate deacetylase from Caulobacter crescentus (378 aa)%2C FASTA scores: opt: 661%2C E(): 7.5e-31%2C (38.9%25 identity in 383 aa overlap)%3B O34450||NAGA_BACSU N-acetylglucosamine-6-phosphate deacetylase from Bacillus subtilis (396 aa)%2C FASTA scores: opt: 571%2C E(): 1.2e-25%2C (32.45%25 identity in 376 aa overlap)%3B etc. Equivalent to AAK47778 from Mycobacterium tuberculosis strain CDC1551 (346 aa) but longer 37 aa. Belongs to the NagA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nagA;locus_tag=Rv3332;product=Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase);protein_id=CCP46153.1;transl_table=11
AL123456.3	EMBL	gene	3719937	3720782	.	-	.	ID=gene-Rv3333c;Name=Rv3333c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3333c
AL123456.3	EMBL	CDS	3719937	3720782	.	-	0	ID=cds-CCP46154.1;Parent=gene-Rv3333c;Dbxref=EnsemblGenomes-Gn:Rv3333c,EnsemblGenomes-Tr:CCP46154,InterPro:IPR007969,UniProtKB/TrEMBL:O53383,NCBI_GP:CCP46154.1;Name=CCP46154.1;Note=Rv3333c%2C (MTV016.33c)%2C len: 281 aa. Hypothetical unknown pro-rich protein. Equivalent to AAK47780 hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (265 aa) but longer 16 aa. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv3333c;product=Hypothetical proline rich protein;protein_id=CCP46154.1;transl_table=11
AL123456.3	EMBL	gene	3721257	3721697	.	+	.	ID=gene-Rv3334;Name=Rv3334;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3334
AL123456.3	EMBL	CDS	3721257	3721697	.	+	0	ID=cds-CCP46155.1;Parent=gene-Rv3334;Dbxref=EnsemblGenomes-Gn:Rv3334,EnsemblGenomes-Tr:CCP46155,GOA:O53384,InterPro:IPR000551,InterPro:IPR009061,InterPro:IPR015358,UniProtKB/TrEMBL:O53384,NCBI_GP:CCP46155.1;Name=CCP46155.1;Note=Rv3334%2C (MTV016.34)%2C len: 146 aa. Probable transcriptional regulator%2C similar to many regulatory proteins (notably mercury resistance operon regulators) e.g. Q9HXV1|PA3689 probable transcriptional regulator MerR family from Pseudomonas aeruginosa (156 aa)%2C FASTA scores: opt: 275%2C E(): 1.6e-11%2C (35.95%25 identity in 139 aa overlap)%3B Q9AKR6|PBRR lead resistance operon regulator from Ralstonia metallidurans strain CH34 (plasmid pMOL30) (145 aa)%2C FASTA scores: opt: 267%2C E(): 5.2e-11%2C (35.8%25 identity in 134 aa overlap)%3B P95838|MERR mercuric resistance operon regulator from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (144 aa)%2C FASTA scores: opt: 266%2C E(): 6e-11%2C(31.35%25 identity in 118 aa overlap)%3B P22853|MERR_BACSR mercuric resistance operon regulator from Bacillus sp. strain RC607 (132 aa)%2C FASTA scores: opt: 262%2C E(): 1e-10%2C(34.6%25 identity in 130 aa overlap)%3B etc. Contains probable helix-turn-helix motif at aa 1-22 (Score 1478%2C +4.22 SD). Seems to belong to the MerR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3334;product=Probable transcriptional regulatory protein (probably MerR-family);protein_id=CCP46155.1;transl_table=11
AL123456.3	EMBL	gene	3721731	3722600	.	-	.	ID=gene-Rv3335c;Name=Rv3335c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3335c
AL123456.3	EMBL	CDS	3721731	3722600	.	-	0	ID=cds-CCP46156.1;Parent=gene-Rv3335c;Dbxref=EnsemblGenomes-Gn:Rv3335c,EnsemblGenomes-Tr:CCP46156,InterPro:IPR005274,InterPro:IPR017039,UniProtKB/TrEMBL:O53385,NCBI_GP:CCP46156.1;Name=CCP46156.1;Note=Rv3335c%2C (MTV016.35c)%2C len: 289 aa. Probable conserved integral membrane protein%2C equivalent to Q49909|ML0687 putative membrane protein U0308AA from Mycobacterium leprae (313 aa)%2C FASTA scores: opt: 1299%2CE(): 8.9e-75%2C (68.75%25 identity in 288 aa overlap). Also similar to other hypothetical bacterial proteins e.g. BAB37825|ECS4402 from Escherichia coli strain O157:H7 (alias P37642|YHJD_ECOLI|B3522 strain K12) (337 aa)%2C FASTA scores: opt: 591%2C E(): 4.2e-30%2C (35.15%25 identity in 273 aa overlap)%3B P45417|YHJD_ERWCH from Erwinia chrysanthemi (328 aa)%2C FASTA scores: opt: 500%2C E(): 2.2e-24%2C (34.9%25 identity in 275 aa overlap)%3B Q9KZA0|SC5G8.14 putative integral membrane protein from Streptomyces coelicolor (321 aa)%2CFASTA scores: opt: 321%2C E(): 4.3e-13%2C (27.3%25 identity in 271 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3335c;product=Probable conserved integral membrane protein;protein_id=CCP46156.1;transl_table=11
AL123456.3	EMBL	gene	3722621	3723631	.	-	.	ID=gene-Rv3336c;Name=trpS;gbkey=Gene;gene=trpS;gene_biotype=protein_coding;locus_tag=Rv3336c
AL123456.3	EMBL	CDS	3722621	3723631	.	-	0	ID=cds-CCP46157.1;Parent=gene-Rv3336c;Dbxref=EnsemblGenomes-Gn:Rv3336c,EnsemblGenomes-Tr:CCP46157,GOA:P9WFT3,InterPro:IPR001412,InterPro:IPR002305,InterPro:IPR002306,InterPro:IPR014729,InterPro:IPR024109,NCBI_GP:CCP46157.1;Name=CCP46157.1;Note=Rv3336c%2C (MTV016.36c)%2C len: 336 aa. Probable trpS%2Ctryptophanyl-tRNA synthetase%2C equivalent to Q49901|SYW_MYCLE|TRPS|ML0686|L308_C1_147 tryptophanyl-tRNA synthetase from Mycobacterium leprae (343 aa)%2C FASTA scores: opt: 1859%2C E(): 4.8e-107%2C (83.75%25 identity in 339 aa overlap). Also similar to many e.g. Q9KZA7|TRPS2 from Streptomyces coelicolor (339 aa)%2C FASTA scores: opt: 1359%2CE(): 2.6e-76%2C (60.3%25 identity in 335 aa overlap)%3B Q9EYY6|TRPS from Klebsiella aerogenes (334 aa)%2C FASTA scores: opt: 1077%2C E(): 5.5e-59%2C (52.15%25 identity in 328 aa overlap)%3B P00954|SYW_ECOLI|TRPS|B3384 from Escherichia coli strain K12 (334 aa)%2C FASTA scores: opt: 1074%2C E(): 8.3e-59%2C(51.85%25 identity in 328 aa overlap)%3B etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Belongs to class-I aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trpS;inference=protein motif:PROSITE:PS00178;locus_tag=Rv3336c;product=Probable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tryptophan translase);protein_id=CCP46157.1;transl_table=11
AL123456.3	EMBL	gene	3723656	3724042	.	+	.	ID=gene-Rv3337;Name=Rv3337;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3337
AL123456.3	EMBL	CDS	3723656	3724042	.	+	0	ID=cds-CCP46158.1;Parent=gene-Rv3337;Dbxref=EnsemblGenomes-Gn:Rv3337,EnsemblGenomes-Tr:CCP46158,InterPro:IPR029058,UniProtKB/TrEMBL:O53387,NCBI_GP:CCP46158.1;Name=CCP46158.1;Note=Rv3337%2C (MTV016.37)%2C len: 128 aa. Conserved hypothetical protein%2C equivalent to N-terminus of Q49926|ML0685 TPEA (putative hydrolase) from Mycobacterium leprae (303 aa)%2C FASTA scores: opt: 362%2C E(): 5.7e-17%2C(74.3%25 identity in 70 aa overlap). Also weak similarity in N-terminus to Q98JT7|BAB49078|MLR1789 probable epoxide hydrolase from Rhizobium loti (Mesorhizobium loti) (300 aa)%2C FASTA scores: opt: 122%2C E(): 0.74%2C (31.95%25 identity in 97 aa overlap). Homology suggests this ORF should be in frame with the following ORF MTV016.38 but no sequence error could be found. Short distance to start of trpS suggests region may not be protein-coding. C-terminus extended since first submission (+47 aa).;gbkey=CDS;locus_tag=Rv3337;product=Conserved hypothetical protein;protein_id=CCP46158.1;transl_table=11
AL123456.3	EMBL	gene	3723904	3724548	.	+	.	ID=gene-Rv3338;Name=Rv3338;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3338
AL123456.3	EMBL	CDS	3723904	3724548	.	+	0	ID=cds-CCP46159.1;Parent=gene-Rv3338;Dbxref=EnsemblGenomes-Gn:Rv3338,EnsemblGenomes-Tr:CCP46159,InterPro:IPR029058,UniProtKB/TrEMBL:O53388,NCBI_GP:CCP46159.1;Name=CCP46159.1;Note=Rv3338%2C (MTV016.38)%2C len: 214 aa. Hypothetical protein%2C equivalent to C-termini of Q49926|ML0685 TPEA (putative hydrolase) from Mycobacterium leprae (303 aa)%2CFASTA scores: opt: 984%2C E(): 2.6e-56%2C (65.4%25 identity in 214 aa overlap)%3B and O32873|MLCB1779.02 hypothetical 31.8 KDA protein (similar to alpha/beta hydrolase fold) from Mycobacterium leprae (292 aa)%2C FASTA scores: opt: 984%2C E(): 2.5e-56%2C (65.4%25 identity in 214 aa overlap). Also similar to C-termini of several hypothetical proteins (generally hydrolases) e.g. Q9K3H6|2SCG18.11 putative hydrolase from Streptomyces coelicolor (316 aa)%2C FASTA scores: opt: 213%2CE(): 1.4e-06%2C (29.75%25 identity in 185 aa overlap). Homology suggests that this ORF should be in frame with the previous ORF MTV016.37 but no sequence error could be found.;gbkey=CDS;locus_tag=Rv3338;product=Conserved hypothetical protein;protein_id=CCP46159.1;transl_table=11
AL123456.3	EMBL	gene	3724615	3725844	.	-	.	ID=gene-Rv3339c;Name=icd1;gbkey=Gene;gene=icd1;gene_biotype=protein_coding;locus_tag=Rv3339c
AL123456.3	EMBL	CDS	3724615	3725844	.	-	0	ID=cds-CCP46160.1;Parent=gene-Rv3339c;Dbxref=EnsemblGenomes-Gn:Rv3339c,EnsemblGenomes-Tr:CCP46160,GOA:P9WKL1,InterPro:IPR004790,InterPro:IPR019818,InterPro:IPR024084,PDB:4HCX,NCBI_GP:CCP46160.1;Name=CCP46160.1;Note=Rv3339c%2C (MTV016.39c)%2C len: 409 aa. Probable icd1%2Cisocitrate dehydrogenase NADP-dependent%2C highly similar to many e.g. Q9A5C8|CC2522 from Caulobacter crescentus (403 aa)%2C FASTA scores: opt: 1972%2C E(): 4.6e-115%2C (72.45%25 identity in 403 aa overlap)%3B AAF73472|ICD from Rhizobium meliloti (404 aa)%2C FASTA scores: opt: 1968%2C E(): 8.1e-115%2C(73.2%25 identity in 403 aa overlap)%3B P50215|IDH_SPHYA from Sphingomonas yanoikuyae (406 aa)%2C FASTA scores: opt: 1964%2CE(): 1.4e-114%2C (71.45%25 identity in 403 aa overlap)%3B etc. Contains PS00470 Isocitrate and isopropylmalate dehydrogenases signature. Belongs to the isocitrate and isopropylmalate dehydrogenases family. Note that in H37Rv%2CRv0066c is named icd2 and Rv3339c is icd1 while in CDC1551 and Erdman strains%2C Rv0066c is icd1 and Rv3339c is icd2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=icd1;inference=protein motif:PROSITE:PS00470;locus_tag=Rv3339c;product=Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP);protein_id=CCP46160.1;transl_table=11
AL123456.3	EMBL	gene	3726127	3727476	.	+	.	ID=gene-Rv3340;Name=metC;gbkey=Gene;gene=metC;gene_biotype=protein_coding;locus_tag=Rv3340
AL123456.3	EMBL	CDS	3726127	3727476	.	+	0	ID=cds-CCP46161.1;Parent=gene-Rv3340;Dbxref=EnsemblGenomes-Gn:Rv3340,EnsemblGenomes-Tr:CCP46161,GOA:O53390,InterPro:IPR000277,InterPro:IPR006235,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:O53390,NCBI_GP:CCP46161.1;Name=CCP46161.1;Note=Rv3340%2C (MTV016.40)%2C len: 449 aa. Probable metC%2CO-acetyl-L-homoserine sulfhydrylase%2C highly similar to many e.g. Q9K9P2|BH2603 O-acetylhomoserine sulfhydrylase from Bacillus halodurans (430 aa)%2C FASTA scores: opt: 1716%2C E(): 3.3e-97%2C (60.45%25 identity in 425 aa overlap)%3B Q9HUE4|METY|PA5025 homocysteine synthase from Pseudomonas aeruginosa (425 aa)%2C FASTA scores: opt: 1517%2C E(): 4.4e-85%2C(56.95%25 identity in 425 aa overlap)%3B Q9WZY4|TM0882 O-acetylhomoserine sulfhydrylase from Thermotoga maritima (430 aa)%2C FASTA scores: opt: 1488%2C E(): 2.6e-83%2C (55.75%25 identity in 418 aa overlap)%3B BAB54344|MLR8465 O-acetylhomoserine sulfhydrylase from Rhizobium loti (Mesorhizobium loti) (426 aa)%2C FASTA scores: opt: 1445%2CE(): 1.1e-80%2C (53.2%25 identity in 419 aa overlap)%3B P50125|CYSD_EMENI O-acetylhomoserine (thiol)-lyase from Emericella nidulans (Aspergillus nidulans) (437 aa)%2C FASTA scores: opt: 1442%2C E(): 1.7e-80%2C (53.7%25 identity in 430 aa overlap)%3B etc. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. Cofactor: pyridoxal phosphate. Belongs to the trans-sulfuration enzymes family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metC;inference=protein motif:PROSITE:PS00868;locus_tag=Rv3340;product=Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase);protein_id=CCP46161.1;transl_table=11
AL123456.3	EMBL	gene	3727488	3728627	.	+	.	ID=gene-Rv3341;Name=metA;gbkey=Gene;gene=metA;gene_biotype=protein_coding;locus_tag=Rv3341
AL123456.3	EMBL	CDS	3727488	3728627	.	+	0	ID=cds-CCP46162.1;Parent=gene-Rv3341;Dbxref=EnsemblGenomes-Gn:Rv3341,EnsemblGenomes-Tr:CCP46162,GOA:P9WJY9,InterPro:IPR000073,InterPro:IPR008220,InterPro:IPR029058,NCBI_GP:CCP46162.1;Name=CCP46162.1;Note=Rv3341%2C (MTV016.41)%2C len: 379 aa. Probable metA%2Chomoserine o-acetyltransferase (see citation below)%2Cequivalent to O32874|METX_MYCLE|meta|ML0682|MLCB1779.11 homoserine O-acetyltransferase from Mycobacterium leprae (382 aa)%2C FASTA scores: opt: 2263%2C E(): 9.2e-129%2C (85.0%25 identity in 380 aa overlap). Also highly similar to many e.g. O68640|METX_CORGL|meta from Corynebacterium glutamicum (Brevibacterium flavum) (379 aa)%2C FASTA scores: opt: 1135%2CE(): 5.9e-61%2C (48.5%25 identity in 371 aa overlap)%3B Q9AAS1|CC0525 from Caulobacter crescentus (382 aa)%2C FASTA scores: opt: 860%2C E(): 2e-44%2C (40.5%25 identity in 363 aa overlap)%3B P94891|METX_LEPME from Leptospira meyeri (379 aa)%2C FASTA scores: opt: 787%2C E(): 4.9e-40%2C (38.2%25 identity in 385 aa overlap)%3B etc. Belongs to the ab hydrolase family%2C HTA subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=metA;locus_tag=Rv3341;product=Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA);protein_id=CCP46162.1;transl_table=11
AL123456.3	EMBL	gene	3728624	3729355	.	+	.	ID=gene-Rv3342;Name=Rv3342;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3342
AL123456.3	EMBL	CDS	3728624	3729355	.	+	0	ID=cds-CCP46163.1;Parent=gene-Rv3342;Dbxref=EnsemblGenomes-Gn:Rv3342,EnsemblGenomes-Tr:CCP46163,GOA:P9WK01,InterPro:IPR013216,InterPro:IPR029063,NCBI_GP:CCP46163.1;Name=CCP46163.1;Note=Rv3342%2C (MTV016.42)%2C len: 243 aa. Possible methyltransferase%2C similar to various proteins e.g. Q9I5X8|PA0558 hypothetical protein from Pseudomonas aeruginosa (255 aa)%2C FASTA scores: opt: 496%2C E(): 4.4e-24%2C(39.85%25 identity in 236 aa overlap)%3B Q9XBC9|CZA382.22c putative rRNA methylase from Amycolatopsis orientalis (259 aa)%2C FASTA scores: opt: 473%2C E(): 1.2e-22%2C (42.45%25 identity in 245 aa overlap)%3B Q9UTA8|SPAC25B8.10 putative methyltransferase from Schizosaccharomyces pombe (Fission yeast) (256 aa)%2C FASTA scores: opt: 470%2C E(): 1.9e-22%2C(35.7%25 identity in 238 aa overlap)%3B and Q9UTA9|SPAC25B8.09 putative methyltransferase from Schizosaccharomyces pombe (Fission yeast) (251 aa)%2C FASTA scores: opt: 418%2C E(): 3.4e-19%2C (31.2%25 identity in 237 aa overlap)%3B etc. Start uncertain. Belongs to the methyltransferase superfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3342;product=Possible methyltransferase (methylase);protein_id=CCP46163.1;transl_table=11
AL123456.3	EMBL	gene	3729364	3736935	.	-	.	ID=gene-Rv3343c;Name=PPE54;gbkey=Gene;gene=PPE54;gene_biotype=protein_coding;locus_tag=Rv3343c
AL123456.3	EMBL	CDS	3729364	3736935	.	-	0	ID=cds-CCP46164.1;Parent=gene-Rv3343c;Dbxref=EnsemblGenomes-Gn:Rv3343c,EnsemblGenomes-Tr:CCP46164,GOA:Q6MWY2,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP46164.1;Name=CCP46164.1;Note=Rv3343c%2C (MTV016.43c)%2C len: 2523 aa. PPE54%2C Member of the Mycobacterium tuberculosis PPE family%2C MPTR subgroup of Gly-%2C Asn-rich proteins. Most similar to O50379|Rv3350c|MTV004.07c|MTV004_5 from Mycobacterium tuberculosis strain H37Rv (3716 aa)%2C FASTA scores: opt: 4672%2C E(): 4e-211%2C (44.2%25 identity in 3174 aa overlap)%3B and also similar to MTV004_3%2C MTCY63_9%2C MTY13E10_17%2CMTY13E10_16%2C MTCY180_1%2C MTV050_1%2C MTCY3C7_23%2C MTV014_3%2CMTCY63_10%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE54;locus_tag=Rv3343c;product=PPE family protein PPE54;protein_id=CCP46164.1;transl_table=11
AL123456.3	EMBL	gene	3736984	3738438	.	-	.	ID=gene-Rv3344c;Name=PE_PGRS49;end_range=3738438,.;gbkey=Gene;gene=PE_PGRS49;gene_biotype=protein_coding;locus_tag=Rv3344c;partial=true
AL123456.3	EMBL	CDS	3736984	3738438	.	-	0	ID=cds-CCP46165.1;Parent=gene-Rv3344c;Dbxref=EnsemblGenomes-Gn:Rv3344c,EnsemblGenomes-Tr:CCP46165,UniProtKB/TrEMBL:L0TFC2,NCBI_GP:CCP46165.1;Name=CCP46165.1;Note=Rv3344c%2C (MTV016.44c)%2C len: 484 aa. PE_PGRS49%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-%2C ala-rich proteins (see Brennan and Delogu%2C 2002). Appears to be a gene fragment%2C should be in-frame with following ORF%2C MTV016.45c%2C frameshift required around 49595 but could not be found on checking BAC and cosmid clones. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53557|Rv3512|MTV023.19 (1079 aa)%2C FASTA scores: opt: 1595%2CE(): 1.8e-54%2C (52.0%25 identity in 544 aa overlap).;end_range=3738438,.;gbkey=CDS;gene=PE_PGRS49;locus_tag=Rv3344c;partial=true;product=PE-PGRS family protein PE_PGRS49;protein_id=CCP46165.1;transl_table=11
AL123456.3	EMBL	gene	3738158	3742774	.	-	.	ID=gene-Rv3345c;Name=PE_PGRS50;gbkey=Gene;gene=PE_PGRS50;gene_biotype=protein_coding;locus_tag=Rv3345c
AL123456.3	EMBL	CDS	3738158	3742774	.	-	0	ID=cds-CCP46166.1;Parent=gene-Rv3345c;Dbxref=EnsemblGenomes-Gn:Rv3345c,EnsemblGenomes-Tr:CCP46166,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MWY0,NCBI_GP:CCP46166.1;Name=CCP46166.1;Note=Rv3345c%2C (MTV004.01c-MTV016.45c)%2C len: 1538 aa. PE_PGRS50%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C 2002). Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419%3B and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS50;locus_tag=Rv3345c;product=PE-PGRS family protein PE_PGRS50;protein_id=CCP46166.1;transl_table=11
AL123456.3	EMBL	gene	3743198	3743455	.	-	.	ID=gene-Rv3346c;Name=Rv3346c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3346c
AL123456.3	EMBL	CDS	3743198	3743455	.	-	0	ID=cds-CCP46167.1;Parent=gene-Rv3346c;Dbxref=EnsemblGenomes-Gn:Rv3346c,EnsemblGenomes-Tr:CCP46167,GOA:O50377,InterPro:IPR021385,UniProtKB/TrEMBL:O50377,NCBI_GP:CCP46167.1;Name=CCP46167.1;Note=Rv3346c%2C (MTV004.02c)%2C len: 85 aa. Conserved transmembrane protein%2C highly similar to mycobacterium hypothetical proteins O50384|Rv3355c|MTV004.12c from strain H37Rv (97 aa)%2C FASTA scores: opt: 413%2C E(): 4.6e-23%2C(85.55%25 identity in 97 aa overlap)%3B O32878|MLCB1779.16c|ML0675 from Mycobacterium leprae (91 aa)%2C FASTA scores: opt: 349%2C E(): 1.7e-18%2C (67.35%25 identity in 95 aa overlap). Contains possible membrane spanning regions.;gbkey=CDS;locus_tag=Rv3346c;product=Conserved transmembrane protein;protein_id=CCP46167.1;transl_table=11
AL123456.3	EMBL	repeat_region	3743198	3743404	.	+	.	ID=id-AL123456.3:3743198..3743404;Note=207 bp imperfect direct repeat 1%2C 199/207 bp identical to second copy at 3769514..3769720;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3743402	3743510	.	+	.	ID=id-AL123456.3:3743402..3743510;Note=109 bp imperfect direct repeat 1%2C 95/109 bp identical to second copy at 3769754..3769862;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3743508	3743605	.	+	.	ID=id-AL123456.3:3743508..3743605;Note=98 bp imperfect direct repeat 1%2C 82/98 bp identical to the second copy at 3770994..3771091;gbkey=repeat_region
AL123456.3	EMBL	gene	3743711	3753184	.	-	.	ID=gene-Rv3347c;Name=PPE55;gbkey=Gene;gene=PPE55;gene_biotype=protein_coding;locus_tag=Rv3347c
AL123456.3	EMBL	CDS	3743711	3753184	.	-	0	ID=cds-CCP46168.1;Parent=gene-Rv3347c;Dbxref=EnsemblGenomes-Gn:Rv3347c,EnsemblGenomes-Tr:CCP46168,GOA:Q6MWX9,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:Q6MWX9,NCBI_GP:CCP46168.1;Name=CCP46168.1;Note=Rv3347c%2C (MTV004.03c)%2C len: 3157 aa. PPE55%2C Member of the Mycobacterium tuberculosis PPE family%2C Gly-%2C Ala-%2CAsn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551%2C e.g. O50379|Rv3350c|MTV004.07c (3716 aa)%2C FASTA scores: opt: 6497%2C E(): 0%2C (61.65%25 identity in 3756 aa overlap)%3B and other upstream ORFs MTV004_5%2C MTY13E10_15%2C MTCY28_16%2CMTCY63_9%2C MTY13E10_17%2C MTCY180_1%3B etc. Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE55;locus_tag=Rv3347c;product=PPE family protein PPE55;protein_id=CCP46168.1;transl_table=11
AL123456.3	EMBL	gene	3753765	3754256	.	+	.	ID=gene-Rv3348;Name=Rv3348;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3348
AL123456.3	EMBL	CDS	3753765	3754256	.	+	0	ID=cds-CCP46169.1;Parent=gene-Rv3348;Dbxref=EnsemblGenomes-Gn:Rv3348,EnsemblGenomes-Tr:CCP46169,GOA:P96234,InterPro:IPR002525,UniProtKB/TrEMBL:P96234,NCBI_GP:CCP46169.1;Name=CCP46169.1;Note=Rv3348%2C (MTV004.04)%2C len: 163 aa. Probable transposase%2C partially similar to several insertion elements e.g. P19834|YI11_STRCL insertion element IS116 hypothetical 44.8 KDA protein (similar to IS900 of Mycobacterium paratuberculosis) from Streptomyces clavuligerus (399 aa)%2C FASTA scores: opt: 146%2C E(): 0.016%2C(29.1%25 identity in 158 aa overlap).;gbkey=CDS;locus_tag=Rv3348;product=Probable transposase;protein_id=CCP46169.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3753765	3754253	.	+	.	ID=id-Rv3348;Note=IS1608'%2C len: 489 nt. Insertion sequence IS1608'.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1608'
AL123456.3	EMBL	gene	3754293	3755033	.	-	.	ID=gene-Rv3349c;Name=Rv3349c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3349c
AL123456.3	EMBL	CDS	3754293	3755033	.	-	0	ID=cds-CCP46170.1;Parent=gene-Rv3349c;Dbxref=EnsemblGenomes-Gn:Rv3349c,EnsemblGenomes-Tr:CCP46170,GOA:V5QQS8,InterPro:IPR002560,UniProtKB/TrEMBL:V5QQS8,NCBI_GP:CCP46170.1;Name=CCP46170.1;Note=Rv3349c%2C (MTV004.05c)%2C len: 246 aa. Probable transposase pseudogene fragment%2C similar to part of Q50911|U10634 IS204 putative transposase from nocardia asteroides (377 aa)%2C FASTA scores: opt: 288%2C E(): 8.3e-11%2C(48.5%25 identity in 97 aa overlap)%3B and others.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3349c;product=Probable transposase;protein_id=CCP46170.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3754296	3755033	.	-	.	ID=id-Rv3349c;Note=IS1561'%2C len: 738 nt. Insertion sequence IS1561'.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1561'
AL123456.3	EMBL	gene	3755952	3767102	.	-	.	ID=gene-Rv3350c;Name=PPE56;gbkey=Gene;gene=PPE56;gene_biotype=protein_coding;locus_tag=Rv3350c
AL123456.3	EMBL	CDS	3755952	3767102	.	-	0	ID=cds-CCP46171.1;Parent=gene-Rv3350c;Dbxref=EnsemblGenomes-Gn:Rv3350c,EnsemblGenomes-Tr:CCP46171,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:Q6MWX8,NCBI_GP:CCP46171.1;Name=CCP46171.1;Note=Rv3350c%2C (MTV004.07c)%2C len: 3716 aa. PPE56%2C Member of the Mycobacterium tuberculosis PPE family of Gly-%2C Ala-%2CAsn-rich proteins%2C similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551%2C e.g. O50378|Rv3347c|MTV004.03c (3157 aa)%2C FASTA scores: opt: 6497%2C E(): 0%2C (61.65%25 identity in 3756 aa overlap)%3B MTCY28_16%2C MTV050_2%2C MTY13E10_17%2C MTCY63_10%2C MTCY180_1%2CMTCY63_9%2C MTV050_1%2C MTV014_3%2C MTY13E10_15%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE56;locus_tag=Rv3350c;product=PPE family protein PPE56;protein_id=CCP46171.1;transl_table=11
AL123456.3	EMBL	gene	3767346	3768140	.	-	.	ID=gene-Rv3351c;Name=Rv3351c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3351c
AL123456.3	EMBL	CDS	3767346	3768140	.	-	0	ID=cds-CCP46172.1;Parent=gene-Rv3351c;Dbxref=EnsemblGenomes-Gn:Rv3351c,EnsemblGenomes-Tr:CCP46172,GOA:O50380,InterPro:IPR012951,UniProtKB/TrEMBL:O50380,NCBI_GP:CCP46172.1;Name=CCP46172.1;Note=Rv3351c%2C (MTV004.08c)%2C len: 264 aa. Hypothetical protein%2C highly similar to C-terminal region (aa 292-479) of O53608|Rv0063|MTV030.06 oxidoreductase from Mycobacterium tuberculosis (479 aa)%2C FASTA scores: opt: 699%2C E(): 1.7e-36%2C (54.75%25 identity in 190 aa overlap). Shows some similarity to Q9KYD6|SCD72A.20 putative lipoprotein (fragment) from Streptomyces coelicolor (403 aa)%2C FASTA scores: opt: 192%2C E(): 9.1e-05%2C (27.9%25 identity in 154 aa overlap)%3B and P71091|YGAK hypothetical 54.4 KDA protein from Bacillus subtilis (480 aa)%2C FASTA scores: opt: 174%2C E(): 0.0014%2C (26.5%25 identity in 166 aa overlap). Note that the two upstream ORFs Rv3352c and Rv3353c also show similarity to Rv0063 (MTV030_7). Sequence was checked but no errors found. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;locus_tag=Rv3351c;product=Conserved hypothetical protein;protein_id=CCP46172.1;transl_table=11
AL123456.3	EMBL	gene	3768222	3768593	.	-	.	ID=gene-Rv3352c;Name=Rv3352c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3352c
AL123456.3	EMBL	CDS	3768222	3768593	.	-	0	ID=cds-CCP46173.1;Parent=gene-Rv3352c;Dbxref=EnsemblGenomes-Gn:Rv3352c,EnsemblGenomes-Tr:CCP46173,GOA:O50381,InterPro:IPR006094,InterPro:IPR016166,InterPro:IPR016169,UniProtKB/TrEMBL:O50381,NCBI_GP:CCP46173.1;Name=CCP46173.1;Note=Rv3352c%2C (MTV004.09c)%2C len: 123 aa. Possible oxidoreductase%2C similar to part of several oxidoreductases (and hypothetical proteins) from diverse organisms e.g. Q9KYD6|SCD72A.20 putative lipoprotein (fragment) from Streptomyces coelicolor (403 aa)%2C FASTA scores: opt: 348%2CE(): 7.9e-15%2C (51.0%25 identity in 102 aa overlap)%3B BAB53081|MLR6875 probable oxidoreductase from Rhizobium loti (Mesorhizobium loti) (479 aa)%2C FASTA scores: opt: 262%2CE(): 2.3e-09%2C (53.85%25 identity in 78 aa overlap)%3B O94206|OX1 oxidoreductase from Claviceps purpurea (Ergot fungus) (483 aa)%2C FASTA scores: opt: 245%2C E(): 2.7e-08%2C(42.6%25 identity in 115 aa overlap)%3B Q9KHK2|ENCM putative FAD-dependent oxygenase ENCM from Streptomyces maritimus (464 aa)%2C FASTA scores: opt: 238%2C E(): 7.2e-08%2C (43.95%25 identity in 91 aa overlap)%3B etc. Also highly similar to part of O53608|Rv0063|MTV030.06 oxidoreductase (479 aa)%2CFASTA scores: opt: 599%2C E(): 1.6e-30%2C (71.55%25 identity in 123 aa overlap)%3B and to other Mycobacterium tuberculosis proteins e.g. Rv3353c and Rv3351c. All show similarity to a family of oxidoreductases in Mycobacterium tuberculosis%2Csuggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found.;gbkey=CDS;locus_tag=Rv3352c;product=Possible oxidoreductase;protein_id=CCP46173.1;transl_table=11
AL123456.3	EMBL	gene	3768736	3768996	.	-	.	ID=gene-Rv3353c;Name=Rv3353c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3353c
AL123456.3	EMBL	CDS	3768736	3768996	.	-	0	ID=cds-CCP46174.1;Parent=gene-Rv3353c;Dbxref=EnsemblGenomes-Gn:Rv3353c,EnsemblGenomes-Tr:CCP46174,UniProtKB/TrEMBL:O50382,NCBI_GP:CCP46174.1;Name=CCP46174.1;Note=Rv3353c%2C (MTV004.10c)%2C len: 86 aa. Hypothetical protein%2C showing some similarity to Q9X5Q4|MITR MITR protein from Streptomyces lavendulae (514 aa)%2C FASTA scores: opt: 134%2C E(): 0.09%2C (29.5%25 identity in 78 aa overlap)%3B and weak to Q49720|B1549_C3_218 from Mycobacterium leprae (222 aa)%2C FASTA scores: opt: 99%2C E(): 8.8%2C (32.9%25 identity in 76 aa overlap). But highly similar to N-terminal part of O53608|Rv0063|MTV030.06 oxidoreductase from Mycobacterium tuberculosis (479 aa)%2CFASTA scores: opt: 305%2C E(): 4.9e-13%2C (52.9%25 identity in 87 aa overlap)%3B and some similarity can be found with Rv3352c and Rv3351c. All show similarity to a family of oxidoreductases in Mycobacterium tuberculosis%2C suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found. Start changed since original submission.;gbkey=CDS;locus_tag=Rv3353c;product=Conserved hypothetical protein;protein_id=CCP46174.1;transl_table=11
AL123456.3	EMBL	gene	3769111	3769500	.	+	.	ID=gene-Rv3354;Name=Rv3354;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3354
AL123456.3	EMBL	CDS	3769111	3769500	.	+	0	ID=cds-CCP46175.1;Parent=gene-Rv3354;Dbxref=EnsemblGenomes-Gn:Rv3354,EnsemblGenomes-Tr:CCP46175,GOA:O50383,InterPro:IPR007969,UniProtKB/TrEMBL:O50383,NCBI_GP:CCP46175.1;Name=CCP46175.1;Note=Rv3354%2C (MTV004.11)%2C len: 129 aa. Conserved hypothetical protein%2C equivalent (but shorter 29 aa) to Q9CCM4|ML0676 hypothetical protein from Mycobacterium leprae (158 aa)%2C FASTA scores: opt: 467%2C E(): 3.3e-21%2C(55.9%25 identity in 127 aa overlaps). Highly similar to O33192|LPRJ|Rv1690|MTCI125.12 hypothetical protein from Mycobacterium tuberculosis (127 aa)%2C FASTA scores: opt: 329%2C E(): 4.7e-13%2C (46.95%25 identity in 115 aa overlap)%3B and also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O07222|Rv1810|MTCY16F9.04c (118 aa)%2C FASTA scores: opt: 195%2C E(): 4.2e-05%2C (37.15%25 identity in 113 aa overlap)%3B MTCI125_11%2C MTCY16F9_4%2C MTV049_25. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3354;product=Conserved hypothetical protein;protein_id=CCP46175.1;transl_table=11
AL123456.3	EMBL	gene	3769514	3769807	.	-	.	ID=gene-Rv3355c;Name=Rv3355c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3355c
AL123456.3	EMBL	CDS	3769514	3769807	.	-	0	ID=cds-CCP46176.1;Parent=gene-Rv3355c;Dbxref=EnsemblGenomes-Gn:Rv3355c,EnsemblGenomes-Tr:CCP46176,InterPro:IPR021385,UniProtKB/TrEMBL:O50384,NCBI_GP:CCP46176.1;Name=CCP46176.1;Note=Rv3355c%2C (MTV004.12c)%2C len: 97 aa. Probable integral membrane protein%2C equivalent to O32878|MLCB1779.16c|ML0675 hypothetical 9.6 KDA protein from Mycobacterium leprae (91 aa)%2C FASTA scores: opt: 439%2C E(): 3.9e-23%2C (78.9%25 identity in 90 aa overlap). Identical%2C but with a gap%2C to O50377|Rv3346c|MTV004.02c hypothetical 8.9 KDA protein from Mycobacterium tuberculosis (85 aa)%2C FASTA scores: opt: 413%2CE(): 2.1e-21%2C (85.55%25 identity in 97 aa overlap). Also some similarity to other proteins e.g. Q9K3J5|SC2A6.10 putative integral membrane protein from Streptomyces coelicolor (178 aa)%2C FASTA scores: opt: 147%2C E(): 0.003%2C (31.25%25 identity in 80 aa overlap).;gbkey=CDS;locus_tag=Rv3355c;product=Probable integral membrane protein;protein_id=CCP46176.1;transl_table=11
AL123456.3	EMBL	repeat_region	3769514	3769720	.	+	.	ID=id-AL123456.3:3769514..3769720;Note=207 bp imperfect direct repeat 2%2C 199/207 bp identical to first copy at 3743198..3743404;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	3769754	3769862	.	+	.	ID=id-AL123456.3:3769754..3769862;Note=109 bp imperfect direct repeat 2%2C 95/109 bp identical to first copy at 3743402..3743510;gbkey=repeat_region
AL123456.3	EMBL	gene	3769804	3770649	.	-	.	ID=gene-Rv3356c;Name=folD;gbkey=Gene;gene=folD;gene_biotype=protein_coding;locus_tag=Rv3356c
AL123456.3	EMBL	CDS	3769804	3770649	.	-	0	ID=cds-CCP46177.1;Parent=gene-Rv3356c;Dbxref=EnsemblGenomes-Gn:Rv3356c,EnsemblGenomes-Tr:CCP46177,GOA:P9WG81,InterPro:IPR000672,InterPro:IPR016040,InterPro:IPR020630,InterPro:IPR020631,PDB:2C2X,PDB:2C2Y,NCBI_GP:CCP46177.1;Name=CCP46177.1;Note=Rv3356c%2C (MTV004.13c)%2C len: 281 aa. Probable folD%2Cbifunctional enzyme include methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase %2Cequivalent to O32879|fold|ML0674 methylenetetrahydrofolate dehydrogenase (putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase) from Mycobacterium leprae (282 aa)%2C FASTA scores: opt: 1624%2CE(): 1.2e-93%2C (86.45%25 identity in 281 aa overlap). Also similar to many others e.g. Q9K3J6|fold from Streptomyces coelicolor (284 aa)%2C FASTA scores: opt: 1223%2C E(): 9.5e-69%2C(66.65%25 identity in 279 aa overlap)%3B Q9K966|fold from Bacillus halodurans (279 aa)%2C FASTA scores: opt: 886%2C E(): 7.7e-48%2C (47.15%25 identity in 280 aa overlap)%3B P54382|FOLD_BACSU from Bacillus subtilis (283 aa)%2C FASTA scores: opt: 820%2C E(): 9.7e-44%2C (45.7%25 identity in 280 aa overlap)%3B P51696|FOLD_PHOPO from Photobacterium phosphoreum (285 aa)%2C FASTA scores: opt: 778%2C E(): 4e-41%2C (44.9%25 identity in 283 aa overlap)%3B P24186|FOLD_ECOLI|ads|B0529 from Escherichia coli (287 aa)%2C FASTA scores: opt: 741%2CE(): 0%2C44.4%2C (44.4%25 identity in 277 aa overlap)%3B etc. Also highly similar to MLCB1779_9 from Mycobacterium leprae cosmid B1779 (282 aa) (86.5%25 identity in 281 aa overlap). Similar to other dehydrogenase/cyclohydrolase enzymes or domains.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=folD;locus_tag=Rv3356c;product=Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase;protein_id=CCP46177.1;transl_table=11
AL123456.3	EMBL	gene	3770773	3771048	.	+	.	ID=gene-Rv3357;Name=relJ;gbkey=Gene;gene=relJ;gene_biotype=protein_coding;gene_synonym=relB3,yefM;locus_tag=Rv3357
AL123456.3	EMBL	CDS	3770773	3771048	.	+	0	ID=cds-CCP46178.1;Parent=gene-Rv3357;Dbxref=EnsemblGenomes-Gn:Rv3357,EnsemblGenomes-Tr:CCP46178,GOA:P9WF25,InterPro:IPR006442,PDB:3CTO,PDB:3D55,PDB:3OEI,NCBI_GP:CCP46178.1;Name=CCP46178.1;Note=Rv3357%2C (MTV004.14)%2C len: 91 aa. RelJ%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv3358 (See Cherny et al.%2C 2004%3B Pandey and Gerdes%2C 2005)%2C highly similar to other hypothetical proteins e.g. Q9Z4V7|YU1E_STRCO (alias CAC37261|SCBAC17D6.02) ORFU1E (belongs to the PHD/YEFM family) from Streptomyces coelicolor (87 aa)%2C FASTA scores: opt: 344%2C E(): 1.9e-17%2C (62.05%25 identity in 87 aa overlap)%3B P46147|YEFM_ECOLI|B2017 from Escherichia coli strain K12 (83 aa)%2C FASTA scores: opt: 215%2C E(): 1.6e-08%2C (50.0%25 identity in 72 aa overlap)%3B BAB58570|SAV2408 from Staphylococcus aureus subsp. aureus Mu50 (83 aa)%2C FASTA scores: opt: 161%2C E(): 8.8e-05%2C (39.95%25 identity in 77 aa overlap)%3B Q9Z5W8 putative PHD protein from Francisella novicid (85 aa)%2C FASTA scores: opt: 143%2C E(): 0.0016%2C(28.9%25 identity in 83 aa overlap)%3B etc. Also similar to Rv1247c|MTV006.19c (89 aa) (36.9%25 identity in 84 aa overlap). Seems to belong to the PHD/YEFM family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=relJ;locus_tag=Rv3357;product=Antitoxin RelJ;protein_id=CCP46178.1;transl_table=11
AL123456.3	EMBL	repeat_region	3770994	3771091	.	+	.	ID=id-AL123456.3:3770994..3771091;Note=98 bp imperfect direct repeat 2%2C 82/98 bp identical to the first copy at 3743508..3743605;gbkey=repeat_region
AL123456.3	EMBL	gene	3771045	3771302	.	+	.	ID=gene-Rv3358;Name=relK;gbkey=Gene;gene=relK;gene_biotype=protein_coding;gene_synonym=relE3,yoeB;locus_tag=Rv3358
AL123456.3	EMBL	CDS	3771045	3771302	.	+	0	ID=cds-CCP46179.1;Parent=gene-Rv3358;Dbxref=EnsemblGenomes-Gn:Rv3358,EnsemblGenomes-Tr:CCP46179,GOA:P9WF09,InterPro:IPR009614,PDB:3OEI,NCBI_GP:CCP46179.1;Name=CCP46179.1;Note=Rv3358%2C (MTV004.15)%2C len: 85 aa. RelK%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv3357 (See Cherny et al.%2C 2004%3B Pandey and Gerdes%2C 2005)%2C highly similar to other hypohetical proteins e.g. Q9Z4V8|SCBAC17D6.03 from Streptomyces coelicolor (84 aa)%2C FASTA scores: opt: 393%2CE(): 1.1e-21%2C (59.75%25 identity in 82 aa overlap)%3B P56605|YOEB_ECOLI from Escherichia coli (84 aa)%2C FASTA scores: opt: 305%2C E(): 2.2e-15%2C (49.35%25 identity in 77 aa overlap)%3B Q9Z5W7 putative doc protein from Francisella novicida (68 aa)%2C FASTA scores: opt: 253%2C E(): 9.6e-12%2C(51.6%25 identity in 62 aa overlap)%3B BAB58569|SAV2407 from Staphylococcus aureus subsp. aureus Mu50 (88 aa)%2C FASTA scores: opt: 250%2C E(): 2e-11%2C (40.5%25 identity in 84 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=relK;locus_tag=Rv3358;product=Toxin RelK;protein_id=CCP46179.1;transl_table=11
AL123456.3	EMBL	gene	3771344	3772534	.	+	.	ID=gene-Rv3359;Name=Rv3359;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3359
AL123456.3	EMBL	CDS	3771344	3772534	.	+	0	ID=cds-CCP46180.1;Parent=gene-Rv3359;Dbxref=EnsemblGenomes-Gn:Rv3359,EnsemblGenomes-Tr:CCP46180,GOA:O50388,InterPro:IPR001155,InterPro:IPR013785,UniProtKB/TrEMBL:O50388,NCBI_GP:CCP46180.1;Name=CCP46180.1;Note=Rv3359%2C (MTV004.16)%2C len: 396 aa. Possible oxidoreductase%2C similar to N-terminal part of various proteins (hypothetical unknowns or oxidoreductases) e.g. Q9ZB94 hypothetical 69.3 KDA protein from Rhodococcus erythropolis (649 aa)%2C FASTA scores: opt: 509%2C E(): 3e-24%2C(30.0%25 identity in 380 aa overlap)%3B O29991|AF0248 NADH-dependent flavin oxidoreductase from Archaeoglobus fulgidus (378 aa)%2C FASTA scores: opt: 478%2C E(): 1.6e-22%2C(32.45%25 identity in 379 aa overlap)%3B Q9HUH9|PA4986 probable oxidoreductase from Pseudomonas aeruginosa (648 aa)%2C FASTA scores: opt: 412%2C E(): 3.3e-18%2C (30.45%25 identity in 384 aa overlap)%3B Q9KCT8|BH1481 NADH oxidase from Bacillus halodurans (338 aa)%2C FASTA scores: opt: 404%2C E(): 6.1e-18%2C(30.2%25 identity in 275 aa overlap)%3B etc. Some weak similarity to Mycobacterium leprae MLCB1779_10.;gbkey=CDS;locus_tag=Rv3359;product=Possible oxidoreductase;protein_id=CCP46180.1;transl_table=11
AL123456.3	EMBL	gene	3772651	3773019	.	+	.	ID=gene-Rv3360;Name=Rv3360;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3360
AL123456.3	EMBL	CDS	3772651	3773019	.	+	0	ID=cds-CCP46181.1;Parent=gene-Rv3360;Dbxref=EnsemblGenomes-Gn:Rv3360,EnsemblGenomes-Tr:CCP46181,InterPro:IPR000253,InterPro:IPR008984,UniProtKB/TrEMBL:O50389,NCBI_GP:CCP46181.1;Name=CCP46181.1;Note=Rv3360%2C (MTV004.17)%2C len: 122 aa. Hypothetical protein%2C highly similar to the N-terminus of O65934|Rv1747|MTCY28.10|MTCY04C12.31 probable ABC-transporter ATP-binding protein from Mycobacterium tuberculosis (865 aa)%2C FASTA scores: opt: 480%2C E(): 4.7e-25%2C (61.0%25 identity in 118 aa overlap)%3B and some similarity with the N-terminus of P96214|Rv3863|MTCY01A6.05c hypothetical 41.1 KDA protein from Mycobacterium tuberculosis (392 aa)%2C FASTA scores: opt: 138%2C E(): 0.033%2C (31.95%25 identity in 97 aa overlap). Some weak similarity with the N-terminus of other hypothetical proteins e.g. P73823|CYAA|SLR1991 adenylate cyclase from Synechocystis sp. strain PCC 6803 (337 aa)%2CFASTA scores: opt: 127%2C E(): 0.16%2C (28.55%25 identity in 112 aa overlap).;gbkey=CDS;locus_tag=Rv3360;product=Conserved hypothetical protein;protein_id=CCP46181.1;transl_table=11
AL123456.3	EMBL	gene	3773016	3773567	.	-	.	ID=gene-Rv3361c;Name=Rv3361c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3361c
AL123456.3	EMBL	CDS	3773016	3773567	.	-	0	ID=cds-CCP46182.1;Parent=gene-Rv3361c;Dbxref=EnsemblGenomes-Gn:Rv3361c,EnsemblGenomes-Tr:CCP46182,InterPro:IPR001646,UniProtKB/TrEMBL:I6YBX3,NCBI_GP:CCP46182.1;Name=CCP46182.1;Note=Rv3361c%2C (MTV004.18c)%2C len: 183 aa. Conserved protein%2C with some similarity to various proteins e.g. P74221|YB52_SYNY3|SLR1152 hypothetical 36.2 KDA protein SLR (contains 5 pentapeptide repeat domains) from Synechocystis sp. strain PCC 6803 (331 aa)%2C FASTA scores: opt: 252%2C E(): 3.9e-10%2C (30.55%25 identity in 167 aa overlap)%3B Q9SE95 FH protein interacting protein FIP2 from Arabidopsis thaliana (Mouse-ear cress) (298 aa)%2C FASTA scores: opt: 207%2C E(): 4.4e-07%2C (30.35%25 identity in 168 aa overlap)%3B Q9A735|CC1891 pentapeptide repeat family protein from Caulobacter crescentus (250 aa)%2C FASTA scores: opt: 181%2C E(): 2.3e-05%2C(24.05%25 identity in 187 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3361c;product=Conserved protein;protein_id=CCP46182.1;transl_table=11
AL123456.3	EMBL	gene	3773574	3774155	.	-	.	ID=gene-Rv3362c;Name=Rv3362c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3362c
AL123456.3	EMBL	CDS	3773574	3774155	.	-	0	ID=cds-CCP46183.1;Parent=gene-Rv3362c;Dbxref=EnsemblGenomes-Gn:Rv3362c,EnsemblGenomes-Tr:CCP46183,GOA:O50391,InterPro:IPR004130,InterPro:IPR027417,UniProtKB/TrEMBL:O50391,NCBI_GP:CCP46183.1;Name=CCP46183.1;Note=Rv3362c%2C (MTV004.19c)%2C len: 193 aa. Probable ATP/GTP-binding protein%2C similar to others from Streptomyces coelicolor e.g. O86519|SC1C2.18c (174 aa)%2CFASTA scores: opt: 731%2C E(): 9.8e-41%2C (66.85%25 identity in 169 aa overlap)%3B Q9XAE1|SC6G9.41c (191 aa)%2C FASTA scores: opt: 730%2C E(): 1.2e-40%2C (63.55%25 identity in 173 aa overlap)%3B Q9L235|SC1A2.06 (184 aa)%2C FASTA scores: opt: 650%2CE(): 1.9e-35%2C (55.95%25 identity in 177 aa overlap)%3B Q9RJ74|SCI41.10c (176 aa)%2C FASTA scores: opt: 618%2C E(): 2.3e-33%2C (55.9%25 identity in 161 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3362c;product=Probable ATP/GTP-binding protein;protein_id=CCP46183.1;transl_table=11
AL123456.3	EMBL	gene	3774136	3774504	.	-	.	ID=gene-Rv3363c;Name=Rv3363c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3363c
AL123456.3	EMBL	CDS	3774136	3774504	.	-	0	ID=cds-CCP46184.1;Parent=gene-Rv3363c;Dbxref=EnsemblGenomes-Gn:Rv3363c,EnsemblGenomes-Tr:CCP46184,GOA:O50392,InterPro:IPR007995,UniProtKB/TrEMBL:O50392,NCBI_GP:CCP46184.1;Name=CCP46184.1;Note=Rv3363c%2C (MTV004.20c)%2C len: 122 aa. Conserved hypothetical protein%2C similar to others from Streptomyces coelicolor e.g. O86523|SC1C2.23c (132 aa)%2C FASTA scores: opt: 236%2C E(): 9e-09%2C (38.5%25 identity in 122 aa overlap)%3B O86520|SC1C2.19c (190 aa)%2C FASTA scores: opt: 231%2C E(): 2.7e-08%2C (41.0%25 identity in 122 aa overlap)%3B Q9X834|SC9B1.14c (119 aa)%2C FASTA scores: opt: 188%2C E(): 1.1e-05%2C (37.5%25 identity in 120 aa overlap)%3B Q9ADJ4|SCBAC14E8.05 (113 aa)%2C FASTA scores: opt: 167%2C E(): 0.00025%2C (33.05%25 identity in 109 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3363c;product=Conserved hypothetical protein;protein_id=CCP46184.1;transl_table=11
AL123456.3	EMBL	gene	3774482	3774874	.	-	.	ID=gene-Rv3364c;Name=Rv3364c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3364c
AL123456.3	EMBL	CDS	3774482	3774874	.	-	0	ID=cds-CCP46185.1;Parent=gene-Rv3364c;Dbxref=EnsemblGenomes-Gn:Rv3364c,EnsemblGenomes-Tr:CCP46185,InterPro:IPR004942,UniProtKB/TrEMBL:O50393,NCBI_GP:CCP46185.1;Name=CCP46185.1;Note=Rv3364c%2C (MTV004.21c)%2C len: 130 aa. Conserved protein%2C highly similar to others from Streptomyces coelicolor e.g. O86524|SC1C2.24c (137 aa)%2C FASTA scores: opt: 466%2C E(): 1.3e-22%2C (58.6%25 identity in 116 aa overlap)%3B O86521|SC1C2.20c (140 aa)%2C FASTA scores: opt: 445%2C E(): 2.7e-21%2C (56.9%25 identity in 116 aa overlap)%3B Q9KZI6|SCG8A.13c (145 aa)%2C FASTA scores: opt: 341%2C E(): 9.5e-15%2C (51.3%25 identity in 113 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3364c;product=Conserved protein;protein_id=CCP46185.1;transl_table=11
AL123456.3	EMBL	gene	3774871	3777501	.	-	.	ID=gene-Rv3365c;Name=Rv3365c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3365c
AL123456.3	EMBL	CDS	3774871	3777501	.	-	0	ID=cds-CCP46186.1;Parent=gene-Rv3365c;Dbxref=EnsemblGenomes-Gn:Rv3365c,EnsemblGenomes-Tr:CCP46186,GOA:Q93IG6,InterPro:IPR003594,InterPro:IPR003660,UniProtKB/TrEMBL:Q93IG6,NCBI_GP:CCP46186.1;Name=CCP46186.1;Note=Rv3365c%2C (MTV004.22c)%2C len: 876 aa. Conserved protein%2C similar to various proteins from Streptomyces coelicolor e.g. O86525|SC1C2.25c hypothetical 139.7 KDA protein (similar to other prokaryotic sensory transduction histidine kinases) (1329 aa)%2C FASTA scores: opt: 879%2C E(): 5.4e-32%2C (29.9%25 identity in 924 aa overlap) (similarity in N-terminal part for this one)%3B O86522|SC1C2.21c hypothetical 119.9 KDA protein (similar to other prokaryotic sensory transduction histidine kinases) (1111 aa)%2C FASTA scores: opt: 855%2C E(): 5.6e-31%2C (28.9%25 identity in 892 aa overlap) (similarity in N-terminal part for this one)%3B Q9KZI5|SCG8A.14c putative membrane protein (862 aa)%2CFASTA scores: opt: 791%2C E(): 3.3e-28%2C (30.8%25 identity in 828 aa overlap)%3B Q9KZN0|SC1A8A.22c (943 aa)%2C FASTA scores: opt: 660%2C E(): 2.5e-22%2C (27.65%25 identity in 893 aa overlap)%3B etc. Similar in part to two consecutive Mycobacterium leprae hypothetical ORFs%2C probably representing a pseudogene: O07701|MLCL383.27 (118 aa)%2CFASTA scores: opt: 430%2C E(): 1e-12%2C (58.25%25 identity in 115 aa overlap)%3B and O07700|MLCL383.26 (111 aa)%2C FASTA scores: opt: 271%2C E(): 1.3e-05%2C (50.4%25 identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases%2Czinc-binding region signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv3365c;product=Conserved protein;protein_id=CCP46186.1;transl_table=11
AL123456.3	EMBL	gene	3777737	3778201	.	+	.	ID=gene-Rv3366;Name=spoU;gbkey=Gene;gene=spoU;gene_biotype=protein_coding;locus_tag=Rv3366
AL123456.3	EMBL	CDS	3777737	3778201	.	+	0	ID=cds-CCP46187.1;Parent=gene-Rv3366;Dbxref=EnsemblGenomes-Gn:Rv3366,EnsemblGenomes-Tr:CCP46187,GOA:O50394,InterPro:IPR001537,InterPro:IPR016914,InterPro:IPR029026,InterPro:IPR029028,UniProtKB/TrEMBL:O50394,NCBI_GP:CCP46187.1;Name=CCP46187.1;Note=Rv3366%2C (MTV004.23)%2C len: 154 aa. Probable spoU%2CtRNA/rRNA methylase%2C equivalent to Q9CCU7|ML0419 putative tRNA/rRNA methyltransferase from Mycobacterium leprae (158 aa)%2C FASTA scores: opt: 861%2C E(): 1.2e-50%2C (83.75%25 identity in 154 aa overlap)%3B and O07698|MLCL383.24c rRNA methylase from Mycobacterium leprae (169 aa)%2C FASTA scores: opt: 861%2CE(): 1.3e-50%2C (83.75%25 identity in 154 aa overlap). Also highly similar to many members of the spoU family of rRNA methylases e.g. Q9K199|NMB0268 RNA methyltransferase (TRMH family) from Neisseria meningitidis (serogroup B) (154 aa)%2CFASTA scores: opt: 534%2C E(): 7.6e-29%2C (50.0%25 identity in 154 aa overlap)%3B and Q9JSM8|NMA2218 from Neisseria meningitidis (serogroup A) (154 aa)%2C FASTA scores: opt: 526%2C E(): 2.6e-28%2C (49.35%25 identity in 154 aa overlap)%3B Q9HU57|PA5127 from Pseudomonas aeruginosa (153 aa)%2C FASTA scores: opt: 531%2C E(): 1.2e-28%2C (52.95%25 identity in 151 aa overlap)%3B P33899|YIBK_ECOLI|B3606 from Escherichia coli strain K12 (157 aa)%2C FASTA scores: opt: 511%2C E(): 2.6e-27%2C(49.35%25 identity in 154 aa overlap)%3B etc. Belongs to the RNA methyltransferase TrmH family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=spoU;locus_tag=Rv3366;product=Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase);protein_id=CCP46187.1;transl_table=11
AL123456.3	EMBL	gene	3778568	3780334	.	+	.	ID=gene-Rv3367;Name=PE_PGRS51;gbkey=Gene;gene=PE_PGRS51;gene_biotype=protein_coding;locus_tag=Rv3367
AL123456.3	EMBL	CDS	3778568	3780334	.	+	0	ID=cds-CCP46188.1;Parent=gene-Rv3367;Dbxref=EnsemblGenomes-Gn:Rv3367,EnsemblGenomes-Tr:CCP46188,InterPro:IPR000084,UniProtKB/TrEMBL:L0TCB8,NCBI_GP:CCP46188.1;Name=CCP46188.1;Note=Rv3367%2C (MTV004.25)%2C len: 588 aa. PE_PGRS51%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50415|Rv3388|MTV004.46 (731 aa)%2C FASTA scores: opt: 1999%2C E(): 7.2e-72%2C (55.0%25 identity in 620 aa overlap)%3B and MTV004_44%2C MTV043_65%2C MTV006_15%2C MTCY63_2%2CMTCY21B4_13%2C MTV023_21%2C MTV008_43%2C MTCY24A1_4%2C MTV023_15%3B etc. Equivalent to AAK47814 from Mycobacterium tuberculosis strain CDC1551 (628 aa) but shorter 37 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS51;locus_tag=Rv3367;product=PE-PGRS family protein PE_PGRS51;protein_id=CCP46188.1;transl_table=11
AL123456.3	EMBL	gene	3780335	3780979	.	-	.	ID=gene-Rv3368c;Name=Rv3368c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3368c
AL123456.3	EMBL	CDS	3780335	3780979	.	-	0	ID=cds-CCP46189.1;Parent=gene-Rv3368c;Dbxref=EnsemblGenomes-Gn:Rv3368c,EnsemblGenomes-Tr:CCP46189,GOA:O50397,InterPro:IPR000415,InterPro:IPR029479,UniProtKB/TrEMBL:O50397,NCBI_GP:CCP46189.1;Name=CCP46189.1;Note=Rv3368c%2C (MTV004.26c)%2C len: 214 aa. Possible oxidoreductase%2C equivalent to O07697|MLCL383.23|ML0418 hypothetical 23.6 KDA protein (putative oxidoreductase) from Mycobacterium leprae (210 aa)%2C FASTA scores: opt: 1215%2C E(): 1.5e-74%2C (81.4%25 identity in 210 aa overlap). Also similar to O30106|AF0131 putative NAD(P)H-flavin oxidoreductase from Archaeoglobus fulgidus (194 aa)%2C FASTA scores: opt: 139%2C E(): 0.028%2C (29.0%25 identity in 207 aa overlap)%3B Q60049|NOX_THETH NADH dehydrogenase from Thermus aquaticus (subsp. thermophilus) (205 aa)%2C FASTA scores: opt: 169%2C E(): 0.00028%2C (28.3%25 identity in 212 aa overlap)%3B and shows some similarity to other hypothetical proteins (unknowns or oxidoreductases).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3368c;product=Possible oxidoreductase;protein_id=CCP46189.1;transl_table=11
AL123456.3	EMBL	gene	3780978	3781412	.	+	.	ID=gene-Rv3369;Name=Rv3369;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3369
AL123456.3	EMBL	CDS	3780978	3781412	.	+	0	ID=cds-CCP46190.1;Parent=gene-Rv3369;Dbxref=EnsemblGenomes-Gn:Rv3369,EnsemblGenomes-Tr:CCP46190,GOA:O50398,InterPro:IPR011576,InterPro:IPR012349,InterPro:IPR019966,UniProtKB/TrEMBL:O50398,NCBI_GP:CCP46190.1;Name=CCP46190.1;Note=Rv3369%2C (MTV004.27)%2C len: 144 aa. Conserved protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c hypothetical 14.7 KDA protein from Mycobacterium leprae (131 aa)%2C FASTA scores: opt: 174%2C E(): 6e-05%2C (67.55%25 identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa)%2CFASTA scores: opt: 125%2C E(): 0.13%2C (31.05%25 identity in 116 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3369;product=Conserved protein;protein_id=CCP46190.1;transl_table=11
AL123456.3	EMBL	gene	3781501	3784740	.	-	.	ID=gene-Rv3370c;Name=dnaE2;gbkey=Gene;gene=dnaE2;gene_biotype=protein_coding;locus_tag=Rv3370c
AL123456.3	EMBL	CDS	3781501	3784740	.	-	0	ID=cds-CCP46191.1;Parent=gene-Rv3370c;Dbxref=EnsemblGenomes-Gn:Rv3370c,EnsemblGenomes-Tr:CCP46191,GOA:P9WNT5,InterPro:IPR003141,InterPro:IPR004013,InterPro:IPR004365,InterPro:IPR004805,InterPro:IPR011708,InterPro:IPR016195,InterPro:IPR023073,InterPro:IPR029460,NCBI_GP:CCP46191.1;Name=CCP46191.1;Note=Rv3370c%2C (MTV004.28c)%2C len: 1079 aa. Probable dnaE2%2CDNA polymerase III%2C alpha chain (see citations below)%2Csimilar to many e.g. BAB51086|MLR4428 from Rhizobium loti (Mesorhizobium loti) (1118 aa)%2C FASTA scores: opt: 1103%2CE(): 8.9e-59%2C (37.65%25 identity in 1075 aa overlap)%3B Q9S291|SCI11.28c from Streptomyces coelicolor (1185 aa)%2CFASTA scores: opt: 937%2C E(): 1e-48%2C (33.4%25 identity in 1090 aa overlap)%3B O67125|DP3A_AQUAE|DNAE|AQ_1008 from Aquifex aeolicus (1161 aa)%2C FASTA scores: opt: 895%2C E(): 3.4e-46%2C(29.9%25 identity in 1071 aa overlap)%3B O51526|DP3A_BORBU from Borrelia burgdorferi (Lyme disease spirochete) (1147 aa)%2CFASTA scores: opt: 835%2C E(): 1.4e-42%2C (30.05%25 identity in 888 aa overlap)%3B etc. Equivalent to AAK47817 from Mycobacterium tuberculosis strain CDC1551 (1098 aa) but shorter 19 aa. Also similar to Mycobacterium tuberculosis DP3A_MYCTU|MTCY48.18c|dnaE1 (29.6%25 identity in 1110 aa overlap). Belongs to DNA polymerase type-C family%2C DNAE subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaE2;locus_tag=Rv3370c;product=Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase);protein_id=CCP46191.1;transl_table=11
AL123456.3	EMBL	gene	3784932	3786272	.	+	.	ID=gene-Rv3371;Name=Rv3371;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3371
AL123456.3	EMBL	CDS	3784932	3786272	.	+	0	ID=cds-CCP46192.1;Parent=gene-Rv3371;Dbxref=EnsemblGenomes-Gn:Rv3371,EnsemblGenomes-Tr:CCP46192,GOA:P9WKA9,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP46192.1;Name=CCP46192.1;Note=Rv3371%2C (MTV004.29)%2C len: 446 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C similar to many Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. O07035|YV30_MYCTU|Rv3130c|MTCY03A2.28|MTCY164.41c (463 aa)%2CFASTA scores: opt: 556%2C E(): 7.7e-28%2C (44.95%25 identity in 447 aa overlap)%3B MTY20B11_9%2C MTCY28_26%2C MTV013_8%2CMTCY21B4_43%2C MTCY493_29%3B etc. Also similar to O07692|MLCL383_9|MLCL383.18c hypothetical 14.1 KDA protein from Mycobacterium leprae (129 aa)%2C FASTA scores: opt: 293%2CE(): 1.3e-11%2C (47.85%25 identity in 117 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3371;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP46192.1;transl_table=11
AL123456.3	EMBL	gene	3786314	3787489	.	+	.	ID=gene-Rv3372;Name=otsB2;gbkey=Gene;gene=otsB2;gene_biotype=protein_coding;locus_tag=Rv3372
AL123456.3	EMBL	CDS	3786314	3787489	.	+	0	ID=cds-CCP46193.1;Parent=gene-Rv3372;Dbxref=EnsemblGenomes-Gn:Rv3372,EnsemblGenomes-Tr:CCP46193,GOA:P9WFZ5,InterPro:IPR003337,InterPro:IPR006379,InterPro:IPR023214,NCBI_GP:CCP46193.1;Name=CCP46193.1;Note=Rv3372%2C (MTV004.30)%2C len: 391 aa. otsB2%2Ctrehalose-6-phosphate phosphatase%2C equivalent to Q49734|OTSB2|OTSP|B1620_F1_1|MLCL383.17c putative trehalose-phosphatase from Mycobacterium leprae (429 aa)%2CFASTA scores: opt: 1675%2C E(): 2.4e-91%2C (67.05%25 identity in 425 aa overlap). Also weakly similar to several trehalose phosphatases e.g. Q9C8B3|F10O5.8 from Arabidopsis thaliana (Mouse-ear cress) (366 aa)%2C FASTA scores: opt: 432%2C E(): 3.1e-18%2C (36.65%25 identity in 281 aa overlap)%3B O27788|MTH1760 from Methanobacterium thermoautotrophicum (264 aa)%2C FASTA scores: opt: 347%2C E(): 2.5e-13%2C (30.75%25 identity in 221 aa overlap)%3B Q9FWQ2 from Oryza sativa (Rice) (382 aa)%2C FASTA scores: opt: 338%2C E(): 1.1e-12%2C(32.5%25 identity in 320 aa overlap)%3B etc. Also similar to part of Mycobacterium tuberculosis Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa)%2C FASTA scores: opt: 1192%2C E(): 1.6e-62%2C (56.65%25 identity in 339 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=otsB2;locus_tag=Rv3372;product=Trehalose 6-phosphate phosphatase OtsB2 (trehalose-phosphatase) (TPP);protein_id=CCP46193.1;transl_table=11
AL123456.3	EMBL	gene	3787726	3788367	.	+	.	ID=gene-Rv3373;Name=echA18;gbkey=Gene;gene=echA18;gene_biotype=protein_coding;locus_tag=Rv3373
AL123456.3	EMBL	CDS	3787726	3788367	.	+	0	ID=cds-CCP46194.1;Parent=gene-Rv3373;Dbxref=EnsemblGenomes-Gn:Rv3373,EnsemblGenomes-Tr:CCP46194,GOA:O50402,InterPro:IPR001753,InterPro:IPR018376,InterPro:IPR029045,UniProtKB/TrEMBL:O50402,NCBI_GP:CCP46194.1;Name=CCP46194.1;Note=Rv3373%2C (MTV004.31)%2C len: 213 aa. Probable echA18%2Cenoyl-CoA hydratase%2C similar to others e.g. P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa)%2C FASTA scores: opt: 423%2CE(): 3.4e-20%2C (37.95%25 identity in 174 aa overlap)%3B Q9X7Q4|SC5F2A.31c from Streptomyces coelicolor (257 aa)%2CFASTA scores: opt: 399%2C E(): 1.2e-18%2C (45.05%25 identity in 171 aa overlap)%3B BAB52005|MLL5584 from Rhizobium loti (Mesorhizobium loti) (257 aa)%2C FASTA scores: opt: 385%2C E(): 9.6e-18%2C (41.95%25 identity in 174 aa overlap)%3B etc. Also some similarity to 3-hydroxybutyryl-CoA dehydratases e.g. P52046|CRT_CLOAB from Clostridium acetobutylicum (261 aa)%2CFASTA scores: opt: 414%2C E(): 1.3e-19%2C (38.3%25 identity in 175 aa overlap). And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c probable enoyl-CoA hydratase (257 aa)%2C FASTA scores: opt: 365%2C E(): 1.9e-16%2C (39.1%25 identity in 174 aa overlap). Belongs to the enoyl-CoA hydratase/isomerase family. Note that this homology extends across the stop codon and directly into the next ORF MTV004.29%2C suggesting a possible readthrough of the TGA stop codon.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA18;locus_tag=Rv3373;product=Probable enoyl-CoA hydratase EchA18 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP46194.1;transl_table=11
AL123456.3	EMBL	gene	3788368	3788616	.	+	.	ID=gene-Rv3374;Name=echA18.1;gbkey=Gene;gene=echA18.1;gene_biotype=protein_coding;gene_synonym=echA18';locus_tag=Rv3374
AL123456.3	EMBL	CDS	3788368	3788616	.	+	0	ID=cds-CCP46195.1;Parent=gene-Rv3374;Dbxref=EnsemblGenomes-Gn:Rv3374,EnsemblGenomes-Tr:CCP46195,InterPro:IPR029045,UniProtKB/TrEMBL:Q6MWX6,NCBI_GP:CCP46195.1;Name=CCP46195.1;Note=Rv3374%2C (MTV004.32)%2C len: 82 aa. Probable echA18.1%2Cenoyl-CoA hydratase C-terminus%2C similar to the C-terminus of several enoyl-CoA hydratases e.g. Q9I5I4|PA0745 from Pseudomonas aeruginosa (272 aa)%2C FASTA scores: opt: 123%2CE(): 0.13%2C (34.55%25 identity in 81 aa overlap)%3B P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa)%2CFASTA scores: opt: 115%2C E(): 0.45%2C (32.95%25 identity in 82 aa overlap)%3B Q9I002|PA2841 from Pseudomonas aeruginosa (263 aa)%2C FASTA scores: opt: 108%2C E(): 1.4%2C (30.95%25 identity in 84 aa overlap)%3B etc. Also some similarity to C-terminus of O29956|AF0285 3-hydroxyacyl-CoA dehydrogenase from Archaeoglobus fulgidus (658 aa)%2C FASTA scores: opt: 116%2CE(): 0.81%2C (34.15%25 identity in 82 aa overlap)%3B and other enzymes. And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c probable enoyl-CoA hydratase (257 aa)%2C FASTA scores: opt: 111%2C E(): 0.83%2C (36.05%25 identity in 86 aa overlap). This homology extends across the upstream TGA stop codon into the upstream ORF MTV004.28%2C suggesting possible readthrough of the previous stop codon. Note that previously known as echA18'.;gbkey=CDS;gene=echA18.1;locus_tag=Rv3374;product=Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP46195.1;transl_table=11
AL123456.3	EMBL	gene	3788621	3790048	.	+	.	ID=gene-Rv3375;Name=amiD;gbkey=Gene;gene=amiD;gene_biotype=protein_coding;locus_tag=Rv3375
AL123456.3	EMBL	CDS	3788621	3790048	.	+	0	ID=cds-CCP46196.1;Parent=gene-Rv3375;Dbxref=EnsemblGenomes-Gn:Rv3375,EnsemblGenomes-Tr:CCP46196,GOA:P9WQ93,InterPro:IPR000120,InterPro:IPR020556,InterPro:IPR023631,NCBI_GP:CCP46196.1;Name=CCP46196.1;Note=Rv3375%2C (MTV004.33)%2C len: 475 aa. Probable amiD%2Camidase%2C similar to various amidases e.g. Q53116|AMDA enantiomerase-selective amidase from Rhodococcus sp. (462 aa)%2C FASTA scores: opt: 1036%2C E(): 1.6e-54%2C (38.6%25 identity in 464 aa overlap)%3B Q9ZHK8|PZAA nicotinamidase/pyrazinamidase from Mycobacterium smegmatis (468 aa)%2C FASTA scores: opt: 930%2C E(): 3.4e-48%2C (36.3%25 identity in 463 aa overlap)%3B Q9A551|CC2613 pyrazinamidase/nicotinamidase from Caulobacter crescentus (464 aa)%2C FASTA scores: opt: 841%2C E(): 7.1e-43%2C (39.45%25 identity in 469 aa overlap)%3B O69768|AMID_PSEPU amidase from Pseudomonas putida (466 aa)%2C FASTA scores: opt: 800%2C E(): 2e-40%2C (33.6%25 identity in 467 aa overlap)%3B O28325|YJ54_ARCFU|AF1954 putative amidase from Archaeoglobus fulgidu (453 aa)%2C FASTA scores: opt: 669%2CE(): 1.3e-32%2C (30.4%25 identity in 467 aa overlap)%3B etc. Also some similarity to AMIB2|Rv1263|MT1301|MTCY50.19c putative amidase from Mycobacterium tuberculosis (462 aa)%2C (31.5%25 identity in 466 aa overlap). Seems belong to the amidase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=amiD;locus_tag=Rv3375;product=Probable amidase AmiD (acylamidase) (acylase);protein_id=CCP46196.1;transl_table=11
AL123456.3	EMBL	gene	3790156	3790809	.	+	.	ID=gene-Rv3376;Name=Rv3376;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3376
AL123456.3	EMBL	CDS	3790156	3790809	.	+	0	ID=cds-CCP46197.1;Parent=gene-Rv3376;Dbxref=EnsemblGenomes-Gn:Rv3376,EnsemblGenomes-Tr:CCP46197,GOA:P9WMS5,InterPro:IPR006439,InterPro:IPR023214,NCBI_GP:CCP46197.1;Name=CCP46197.1;Note=Rv3376%2C (MTV004.34)%2C len: 217 aa. Hypothetical protein%2C similar to various bacterial proteins (notably hydrolases) e.g. Q9RUP0|DR1344 hydrolase from Deinococcus radiodurans (222 aa)%2C FASTA scores: opt: 348%2C E(): 1.8e-15%2C(36.75%25 identity in 215 aa overlap)%3B Q9RXA1|DR0414 hydrolase (CBBY/CBBZ/GPH/YIEH family) from Deinococcus radiodurans (155 aa)%2C FASTA scores: opt: 233%2C E(): 3.5e-08%2C(36.4%25 identity in 151 aa overlap)%3B Q9X0Q9|TM1177 conserved hypothetical protein from Thermotoga maritima (225 aa)%2CFASTA scores: opt: 231%2C E(): 6.6e-08%2C (27.6%25 identity in 221 aa overlap)%3B Q9ABI3|CC0244 hydrolase%2C haloacid dehalogenase-like from Caulobacter crescentus (213 aa)%2CFASTA scores: opt: 213%2C E(): 9.1e-07%2C (28.95%25 identity in 221 aa overlap)%3B BAB38231|ECS4808 putative phosphatase from Escherichia coli strain O157:H7 (206 aa)%2C FASTA scores: opt: 210%2C E(): 1.4e-06%2C (26.95%25 identity in 193 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3376;product=Conserved hypothetical protein;protein_id=CCP46197.1;transl_table=11
AL123456.3	EMBL	gene	3790848	3792353	.	-	.	ID=gene-Rv3377c;Name=Rv3377c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3377c
AL123456.3	EMBL	CDS	3790848	3792353	.	-	0	ID=cds-CCP46198.1;Parent=gene-Rv3377c;Dbxref=EnsemblGenomes-Gn:Rv3377c,EnsemblGenomes-Tr:CCP46198,GOA:O50406,InterPro:IPR008930,NCBI_GP:CCP46198.1;Name=CCP46198.1;Note=Rv3377c%2C (MTV004.35c)%2C len: 501 aa. Halimadienyl diphosphate synthase%3B similarity with various proteins%2Cnotably cyclases involved in steroid biosynthesis in plants and bacteria e.g. BAB52679|MLR6369 from Rhizobium loti (Mesorhizobium loti) (516 aa)%2C FASTA scores: opt: 533%2C E(): 5.6e-27%2C (30.45%25 identity in 522 aa overlap)%3B Q9ZTN8 copalyl diphosphate synthase 1 from Cucurbita maxima (Pumpkin) (Winter squash) (823 aa)%2C FASTA scores: opt: 484%2CE(): 1.2e-23%2C (28.35%25 identity in 388 aa overlap)%3B Q38710|AC22 abietadiene cyclase from Abies grandis (868 aa)%2C FASTA scores: opt: 382%2C E(): 5.2e-17%2C (25.55%25 identity in 462 aa overlap)%3B Q41771|AN1 kaurene synthase a from Zea mays (Maize) (823 aa)%2C FASTA scores: opt: 377%2C E(): 1.1e-16%2C (29.75%25 identity in 390 aa overlap)%3B Q9AJE4 diterpene cyclase-1 from Kitasatospora griseola (Streptomyces griseolosporeus) (499 aa)%2C FASTA scores: opt: 336%2C E(): 3.2e-14%2C (27.5%25 identity in 513 aa overlap)%3B Q9SAU6 E-alpha-bisabolene synthase (fragment) from Abies grandis (782 aa)%2C FASTA scores: opt: 317%2C E(): 7.8e-13%2C(25.25%25 identity in 479 aa overlap)%3B etc. Note that this and the upstream ORF MTV004.36c have a significantly lower GC bias than the rest of the genome. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007). Cofactor: Mg2+.;gbkey=CDS;locus_tag=Rv3377c;product=Halimadienyl diphosphate synthase;protein_id=CCP46198.1;transl_table=11
AL123456.3	EMBL	gene	3792358	3793248	.	-	.	ID=gene-Rv3378c;Name=Rv3378c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3378c
AL123456.3	EMBL	CDS	3792358	3793248	.	-	0	ID=cds-CCP46199.1;Parent=gene-Rv3378c;Dbxref=EnsemblGenomes-Gn:Rv3378c,EnsemblGenomes-Tr:CCP46199,GOA:P9WJ61,InterPro:IPR001441,PDB:3WQK,PDB:3WQL,PDB:3WQM,PDB:3WQN,PDB:4CMV,PDB:4CMW,PDB:4CMX,PDB:4KT8,NCBI_GP:CCP46199.1;Name=CCP46199.1;Note=Rv3378c%2C (MTV004.36c)%2C len: 296 aa. Diterpene synthase. Note that this ORF and the downstream ORF MTV004.35c have a significantly lower GC bias than the rest of the genome. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007). Cofactor: Mg2+.;gbkey=CDS;locus_tag=Rv3378c;product=Diterpene synthase;protein_id=CCP46199.1;transl_table=11
AL123456.3	EMBL	gene	3793257	3794867	.	-	.	ID=gene-Rv3379c;Name=dxs2;gbkey=Gene;gene=dxs2;gene_biotype=protein_coding;locus_tag=Rv3379c
AL123456.3	EMBL	CDS	3793257	3794867	.	-	0	ID=cds-CCP46200.1;Parent=gene-Rv3379c;Dbxref=EnsemblGenomes-Gn:Rv3379c,EnsemblGenomes-Tr:CCP46200,GOA:O50408,InterPro:IPR005475,InterPro:IPR005476,InterPro:IPR005477,InterPro:IPR009014,InterPro:IPR020826,InterPro:IPR029061,UniProtKB/TrEMBL:O50408,NCBI_GP:CCP46200.1;Name=CCP46200.1;Note=Rv3379c%2C (MTV004.37c)%2C len: 536 aa. Probable dxs2%2C1-deoxy-D-xylulose 5-phosphate synthase%2C similar to many e.g. Q9F1V2|DXS from Kitasatospora griseola (Streptomyces griseolosporeus) (649 aa)%2C FASTA scores: opt: 1274%2C E(): 5.4e-71%2C (50.9%25 identity in 570 aa overlap)%3B Q9X7W3|DXS_STRCO|SC6A5.17 from Streptomyces coelicolor (656 aa)%2C FASTA scores: opt: 1248%2C E(): 2.2e-69%2C (50.55%25 identity in 568 aa overlap)%3B Q9RBN6|DXS_STRC1 from Streptomyces sp. strain CL190 (631 aa)%2C FASTA scores: opt: 1237%2C E(): 1e-68%2C (49.1%25 identity in 570 aa overlap)%3B Q50000|DXS_MYCLE|TKTB|ML1038 from Mycobacterium leprae (643 aa)%2C FASTA scores: opt: 1215%2C E(): 2.4e-67%2C (46.75%25 identity in 571 aa overlap)%3B Q9R6S7|DXS_SYNLE from Synechococcus leopoliensis (636 aa)%2C FASTA scores: opt: 849%2C E(): 8.9e-45%2C (38.55%25 identity in 550 aa overlap)%3B etc. Also similar to O07184|DXS_MYCTU|Rv2682c|MT2756|MTCY05A6.03c from Mycobacterium tuberculosis (638 aa)%2C FASTA scores: opt: 1226%2C E(): 4.9e-68%2C (48.9%25 identity in 558 aa overlap). Belongs to the transketolase family%2C DXS subfamily. Cofactor: thiamine pyrophosphate (by similarity). Note that the N-terminus of this putative protein appears to have been interrupted by the adjacent IS6110 element.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dxs2;locus_tag=Rv3379c;product=Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS);protein_id=CCP46200.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3795058	3796412	.	+	.	ID=id-AL123456.3:3795058..3796412;Note=IS6110-15%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-15
AL123456.3	EMBL	repeat_region	3795058	3795085	.	+	.	ID=id-AL123456.3:3795058..3795085;Note=28 bp inverted repeat at the left end of IS6110%2CTGAACCGCCCCGGTGAGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	3795100	3796086	.	-	.	ID=gene-Rv3380c;Name=Rv3380c;end_range=3796086,.;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3380c;partial=true
AL123456.3	EMBL	CDS	3795100	3796086	.	-	0	ID=cds-CCP46201.1;Parent=gene-Rv3380c;Dbxref=EnsemblGenomes-Gn:Rv3380c,EnsemblGenomes-Tr:CCP46201,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP46201.1;Name=CCP46201.1;Note=Rv3380c%2C (MTV004.38c)%2C len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3380c and Rv3381c%2C the sequence UUUUAAAG (directly upstream of Rv3380c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (+ 34 aa).;end_range=3796086,.;gbkey=CDS;locus_tag=Rv3380c;partial=true;product=Probable transposase;protein_id=CCP46201.1;transl_table=11
AL123456.3	EMBL	gene	3796035	3796361	.	-	.	ID=gene-Rv3381c;Name=Rv3381c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3381c
AL123456.3	EMBL	CDS	3796035	3796361	.	-	0	ID=cds-CCP46202.1;Parent=gene-Rv3381c;Dbxref=EnsemblGenomes-Gn:Rv3381c,EnsemblGenomes-Tr:CCP46202,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP46202.1;Name=CCP46202.1;Note=Rv3381c%2C (MTV004.39c)%2C len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3380c and Rv3381c%2C the sequence UUUUAAAG (directly upstream of Rv3380c) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990).;gbkey=CDS;locus_tag=Rv3381c;product=Probable transposase for insertion sequence element IS6110 (fragment);protein_id=CCP46202.1;transl_table=11
AL123456.3	EMBL	repeat_region	3796385	3796412	.	-	.	ID=id-AL123456.3:3796385..3796412;Note=28 bp inverted repeat at the right end of IS6110%2CTGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	3796448	3797437	.	-	.	ID=gene-Rv3382c;Name=lytB1;gbkey=Gene;gene=lytB1;gene_biotype=protein_coding;locus_tag=Rv3382c
AL123456.3	EMBL	CDS	3796448	3797437	.	-	0	ID=cds-CCP46203.1;Parent=gene-Rv3382c;Dbxref=EnsemblGenomes-Gn:Rv3382c,EnsemblGenomes-Tr:CCP46203,GOA:P9WKF9,InterPro:IPR003451,NCBI_GP:CCP46203.1;Name=CCP46203.1;Note=Rv3382c%2C (MTV004.40c)%2C len: 329 aa. Probable lytB1%2ClytB-related protein%2C highly similar to many e.g. Q9HVM7|LYTB_PSEAE|PA4557 from Pseudomonas aeruginosa (314 aa)%2C FASTA scores: opt: 1048%2C E(): 2e-55%2C (53.2%25 identity in 314 aa overlap)%3B Q9JR39|LYTB|NMA0624|NMB1831 from Neisseria meningitidis (serogroup a and B) (322 aa)%2C FASTA scores: opt: 1041%2C E(): 5.4e-55%2C (52.25%25 identity in 312 aa overlap)%3B P22565|LYTB_ECOLI|B0029 from Escherichia coli strain K12 (316 aa)%2C FASTA scores: opt: 1013%2C E(): 2.5e-53%2C(51.45%25 identity in 311 aa overlap) (for more information about lytB protein%2C see citation below)%3B Q9X781|LYTB_MYCLE|LYTB2|ML1938|MLCB1222.06c from Mycobacterium leprae (332 aa)%2C FASTA scores: opt: 979%2C E(): 2.8e-51%2C (51.3%25 identity in 312 aa overlap)%3B etc. Also similar to Q9PAS9|XF2416 drug tolerance protein from Xylella fastidiosa (316 aa)%2C FASTA scores: opt: 1043%2C E(): 4.1e-55%2C (53.65%25 identity in 315 aa overlap). And similar to O53458|Rv1110|LYTB2|MTV017.63 from Mycobacterium tuberculosis (335 aa)%2C FASTA scores: opt: 975%2C E(): 4.9e-51%2C (51.3%25 identity in 312 aa overlap). Belongs to the LytB family.;gbkey=CDS;gene=lytB1;locus_tag=Rv3382c;product=Probable LYTB-related protein LytB1;protein_id=CCP46203.1;transl_table=11
AL123456.3	EMBL	gene	3797437	3798489	.	-	.	ID=gene-Rv3383c;Name=idsB;gbkey=Gene;gene=idsB;gene_biotype=protein_coding;locus_tag=Rv3383c
AL123456.3	EMBL	CDS	3797437	3798489	.	-	0	ID=cds-CCP46204.1;Parent=gene-Rv3383c;Dbxref=EnsemblGenomes-Gn:Rv3383c,EnsemblGenomes-Tr:CCP46204,GOA:O50410,InterPro:IPR000092,InterPro:IPR008949,InterPro:IPR017446,UniProtKB/TrEMBL:O50410,NCBI_GP:CCP46204.1;Name=CCP46204.1;Note=Rv3383c%2C (MTV004.41c)%2C len: 350 aa. Possible idsB%2Cpolyprenyl transferase (polyprenyl diphosphate synthase) %2Csimilar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR geranyl transferase from Streptomyces coelicolor (386 aa)%2C FASTA scores: opt: 908%2CE(): 3.7e-50%2C (48.8/%25 identity in 334 aa overlap)%3B Q9KWG0|GGDPS geranyl geranyl diphosphate synthase from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa)%2C FASTA scores: opt: 801%2C E(): 2e-43%2C (41.5%25 identity in 347 aa overlap)%3B Q9X7V8|SC6A5.12 putative polyprenyl synthetase from Streptomyces coelicolor (378 aa)%2C FASTA scores: opt: 779%2C E(): 5.3e-42%2C (44.45%25 identity in 324 aa overlap)%3B Q9S5E9 farnesyl%2C geranylgeranyl%2C geranylfarnesyl%2Chexaprenyl%2C heptaprenyl diphosphate synthase (self-HEPPS) from Synechococcus elongatus (324 aa)%2C FASTA scores: opt: 563%2C E(): 2.3e-28%2C (39.85%25 identity in 241 aa overlap) (see citation below)%3B O26156|IDSA_METTH|MTH50 bifunctional short chain isoprenyl diphosphate synthase [includes: farnesyl pyrophosphate synthetase (FPP synthetase) (dimethylallyltransferase) and geranyltranstransferase] from Methanobacterium thermoautotrophicum (325 aa)%2C FASTA scores: opt: 540%2C E(): 6.5e-27%2C (35.75%25 identity in 319 aa overlap)%3B P95999|GGPP_SULSO|GDS|GDS-1|SSO0061|C05010|C05_049 geranylgeranyl pyrophosphate synthetase (GGPP synthetase) (GGPS) [includes: dimethylallyltransferase and geranyltranstransferase and farnesyltranstransferase] from Sulfolobus solfataricus (332 aa)%2C FASTA scores: opt: 511%2CE(): 4.5e-25 (36.9%25 identity in 244 aa overlap)%3B etc. Also similar to Q50727|GGPP_MYCTU|Rv3398c|MT3506|MTCY78.30 probable multifunctional geranylgeranyl pyrophosphate synthetase [includes: dimethylallyltransferase%3B geranyltranstransferase%3B farnesyltranstransferase] from Mycobacterium tuberculosis (359 aa)%2C FASTA scores: opt: 687%2C E(): 3.4e-36%2C (39.1%25 identity in 325 aa overlap). Contains PS00723 Polyprenyl synthetases signature 1. Belongs to the FPP/GGPP synthetases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=idsB;inference=protein motif:PROSITE:PS00723;locus_tag=Rv3383c;product=Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase);protein_id=CCP46204.1;transl_table=11
AL123456.3	EMBL	gene	3799243	3799635	.	-	.	ID=gene-Rv3384c;Name=vapC46;gbkey=Gene;gene=vapC46;gene_biotype=protein_coding;locus_tag=Rv3384c
AL123456.3	EMBL	CDS	3799243	3799635	.	-	0	ID=cds-CCP46205.1;Parent=gene-Rv3384c;Dbxref=EnsemblGenomes-Gn:Rv3384c,EnsemblGenomes-Tr:CCP46205,GOA:O50411,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP46205.1;Name=CCP46205.1;Note=Rv3384c%2C (MTV004.42c)%2C len: 130 aa. Possible vapC46%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv3385c%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis e.g. P95252|Rv1962c|MTCY09F9.02 (135 aa)%2C FASTA scores: opt: 266%2C E(): 1.6e-10%2C (43.1%25 identity in 130 aa overlap)%3B and Q50717|YY08_MYCTU|Rv3408|MTCY78.20c (136 aa)%2C FASTA scores: opt: 243%2C E(): 4.8e-09%2C (35.1%25 identity in 131 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC46;locus_tag=Rv3384c;product=Possible toxin VapC46. Contains PIN domain.;protein_id=CCP46205.1;transl_table=11
AL123456.3	EMBL	gene	3799635	3799943	.	-	.	ID=gene-Rv3385c;Name=vapB46;gbkey=Gene;gene=vapB46;gene_biotype=protein_coding;locus_tag=Rv3385c
AL123456.3	EMBL	CDS	3799635	3799943	.	-	0	ID=cds-CCP46206.1;Parent=gene-Rv3385c;Dbxref=EnsemblGenomes-Gn:Rv3385c,EnsemblGenomes-Tr:CCP46206,GOA:P9WF13,InterPro:IPR006442,NCBI_GP:CCP46206.1;Name=CCP46206.1;Note=Rv3385c%2C (MTV004.43c)%2C len: 102 aa. Possible vapB46%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv3386c%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis hypothetical proteins e.g. Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 (99 aa)%2C FASTA scores: opt: 155%2C E(): 0.001%2C (41.05%25 identity in 78 aa overlap)%3B O07782|Rv0596c|MTCY19H5.26 (85 aa)%2C FASTA scores: opt: 136%2C E(): 0.016%2C (39.45%25 identity in 71 aa overlap)%3B P96916|Rv0626|MTCY20H10.07 (86 aa)%2C FASTA scores: opt: 130%2CE(): 0.04%2C (51.2%25 identity in 41 aa overlap)%3B etc. Also similar to prevent host death (PHD) proteins e.g. CAA66834|PHD from Escherichia coli (73 aa)%2C FASTA scores: opt: 113%2C E(): 0.45%2C (39.4%25 identity in 66 aa overlap)%3B and Q06253|PHD_BPP1 from Bacteriophage P1 (73 aa)%2C FASTA scores: opt: 113%2C E(): 0.45%2C (39.4%25 identity in 66 aa overlap).;gbkey=CDS;gene=vapB46;locus_tag=Rv3385c;product=Possible antitoxin VapB46;protein_id=CCP46206.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3799987	3801554	.	+	.	ID=id-AL123456.3:3799987..3801554;Note=IS1560-2%2C len: 1568 nt. Possible Insertion sequence element IS_1560. Second copy in MTCY10G2 from 11273 to 12919.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1560-2
AL123456.3	EMBL	repeat_region	3799987	3800011	.	+	.	ID=id-AL123456.3:3799987..3800011;Note=25 bp inverted repeat at the right end of putative IS1560%2C TAATTACTAGGACCTGAAAAAGTCG;gbkey=repeat_region
AL123456.3	EMBL	gene	3800092	3800796	.	+	.	ID=gene-Rv3386;Name=Rv3386;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3386
AL123456.3	EMBL	CDS	3800092	3800796	.	+	0	ID=cds-CCP46207.1;Parent=gene-Rv3386;Dbxref=EnsemblGenomes-Gn:Rv3386,EnsemblGenomes-Tr:CCP46207,GOA:O50413,InterPro:IPR008490,UniProtKB/TrEMBL:O50413,NCBI_GP:CCP46207.1;Name=CCP46207.1;Note=Rv3386%2C (MTV004.44)%2C len: 234 aa. Possible transposase%2C showing very weak similarity to several is element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa)%2C FASTA scores: opt: 507%2C E(): 8.3e-25%2C (83.9%25 identity in 87 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3386;product=Possible transposase;protein_id=CCP46207.1;transl_table=11
AL123456.3	EMBL	gene	3800786	3801463	.	+	.	ID=gene-Rv3387;Name=Rv3387;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3387
AL123456.3	EMBL	CDS	3800786	3801463	.	+	0	ID=cds-CCP46208.1;Parent=gene-Rv3387;Dbxref=EnsemblGenomes-Gn:Rv3387,EnsemblGenomes-Tr:CCP46208,UniProtKB/TrEMBL:O50414,NCBI_GP:CCP46208.1;Name=CCP46208.1;Note=Rv3387%2C (MTV004.45)%2C len: 225 aa. Possible transposase%2C showing very weak similarity to other is element proteins%2C and similar to various hypothetical proteins.;gbkey=CDS;locus_tag=Rv3387;product=Possible transposase;protein_id=CCP46208.1;transl_table=11
AL123456.3	EMBL	repeat_region	3801530	3801554	.	-	.	ID=id-AL123456.3:3801530..3801554;Note=25 bp inverted repeat at the right end of putative IS1560%2C TAATTACTAAGACCTGAAAAAGTCG;gbkey=repeat_region
AL123456.3	EMBL	gene	3801653	3803848	.	+	.	ID=gene-Rv3388;Name=PE_PGRS52;gbkey=Gene;gene=PE_PGRS52;gene_biotype=protein_coding;locus_tag=Rv3388
AL123456.3	EMBL	CDS	3801653	3803848	.	+	0	ID=cds-CCP46209.1;Parent=gene-Rv3388;Dbxref=EnsemblGenomes-Gn:Rv3388,EnsemblGenomes-Tr:CCP46209,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MWX5,NCBI_GP:CCP46209.1;Name=CCP46209.1;Note=Rv3388%2C (MTV004.46)%2C len: 731 aa. PE_PGRS52%2C Member of the M. tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C similar to many PE-family proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53553|YZ08_MYCTU|RV3508|MTV023.15 (1901 aa)%2C FASTA scores: opt: 2380%2C E(): 3.6e-87%2C (53.8%25 identity in 773 aa overlap)%3B and MTV023_21%2C MTV023_18%2CMTV023_14%2C MTV039_16%2C MTCY441_4. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS52;locus_tag=Rv3388;product=PE-PGRS family protein PE_PGRS52;protein_id=CCP46209.1;transl_table=11
AL123456.3	EMBL	gene	3803919	3804791	.	-	.	ID=gene-Rv3389c;Name=htdY;gbkey=Gene;gene=htdY;gene_biotype=protein_coding;locus_tag=Rv3389c
AL123456.3	EMBL	CDS	3803919	3804791	.	-	0	ID=cds-CCP46210.1;Parent=gene-Rv3389c;Dbxref=EnsemblGenomes-Gn:Rv3389c,EnsemblGenomes-Tr:CCP46210,InterPro:IPR002539,InterPro:IPR029069,UniProtKB/TrEMBL:I6YBZ8,NCBI_GP:CCP46210.1;Name=CCP46210.1;Note=Rv3389c%2C (MTV004.47c)%2C len: 290 aa. Probable htdY%2C3-hydroxyacyl-thioester dehydratase (See Gurvitz et al.%2C2009)%2C shows structural similarity to six others in Mycobacterium tuberculosis (see Castell et al.%2C 2005) especially Rv3538. Also shows similarity to members of short-chain dehydrogenases/reductases (SDR) family e.g. Q9L009|SCC30.12c putative dehydrogenase from Streptomyces coelicolor (333 aa)%2C FASTA scores: opt: 602%2C E(): 2.7e-30%2C(40.35%25 identity in 305 aa overlap)%3B Q19058|E04F6.3 hydratase-dehydrogenase-epimerase from Caenorhabditis elegans (298 aa)%2C FASTA scores: opt: 573%2C E(): 1.6e-28%2C(41.0%25 identity in 266 aa overlap)%3B Q9LBK1|PHAJ2|PA1018 (R)-specific enoyl-CoA hydratase from Pseudomonas aeruginosa (288 aa)%2C FASTA scores: opt: 601%2C E(): 2.7e-30%2C(40.5%25 identity in 294 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=htdY;locus_tag=Rv3389c;product=Probable 3-hydroxyacyl-thioester dehydratase HtdY;protein_id=CCP46210.1;transl_table=11
AL123456.3	EMBL	gene	3804865	3805575	.	+	.	ID=gene-Rv3390;Name=lpqD;gbkey=Gene;gene=lpqD;gene_biotype=protein_coding;locus_tag=Rv3390
AL123456.3	EMBL	CDS	3804865	3805575	.	+	0	ID=cds-CCP46211.1;Parent=gene-Rv3390;Dbxref=EnsemblGenomes-Gn:Rv3390,EnsemblGenomes-Tr:CCP46211,GOA:O50416,InterPro:IPR013078,InterPro:IPR029033,UniProtKB/TrEMBL:O50416,NCBI_GP:CCP46211.1;Name=CCP46211.1;Note=Rv3390%2C (MTV004.48)%2C len: 236 aa. Probable lpqD%2C a conserved lipoprotein with some similarity to various bacterial proteins e.g. Q9F3Q7|SC10F4.03 putative isomerase from Streptomyces coelicolor (224 aa)%2C FASTA scores: opt: 416%2C E(): 2.5e-18%2C (33.0%25 identity in 197 aa overlap)%3B Q9ZAX0|PGM 2%2C3-PDG dependent phosphoglycerate mutase from Amycolatopsis methanolica (205 aa)%2C FASTA scores: opt: 314%2CE(): 3.7e-12%2C (28.55%25 identity in 203 aa overlap)%3B P73454|SLR1748 hypothetical 24.2 KDA protein from Synechocystis sp. strain PCC 6803 (214 aa)%2C FASTA scores: opt: 201%2C E(): 2.8e-05%2C (23.8%25 identity in 189 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. O53817|Rv0754|MTV041.28 PGRS-family protein (584 aa)%2C FASTA scores: opt: 219%2C E(): 5.1e-06%2C (39.8%25 identity in 226 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqD;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3390;product=Probable conserved lipoprotein LpqD;protein_id=CCP46211.1;transl_table=11
AL123456.3	EMBL	gene	3805621	3807573	.	+	.	ID=gene-Rv3391;Name=acrA1;gbkey=Gene;gene=acrA1;gene_biotype=protein_coding;locus_tag=Rv3391
AL123456.3	EMBL	CDS	3805621	3807573	.	+	0	ID=cds-CCP46212.1;Parent=gene-Rv3391;Dbxref=EnsemblGenomes-Gn:Rv3391,EnsemblGenomes-Tr:CCP46212,GOA:O50417,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR013120,InterPro:IPR016040,UniProtKB/TrEMBL:O50417,NCBI_GP:CCP46212.1;Name=CCP46212.1;Note=Rv3391%2C (MTV004.49)%2C len: 650 aa. Possible acrA1%2Cmulti functional protein with fatty acyl-CoA reductase activity in C-terminal part. Indeed C-terminal part highly similar to P94129|ACR1 fatty acyl-CoA reductase from Acinetobacter calcoaceticus (295 aa)%2C FASTA scores: opt: 767%2C E(): 1.4e-36%2C (45.4%25 identity in 260 aa overlap)%3B and similar to other oxidoreductases dehydrogenases/reductases e.g. Q9Y3A1 CGI-93 protein (similarity with SDR family) from Homo sapiens (Human) (291 aa)%2C FASTA scores: opt: 363%2CE(): 1.5e-13%2C (38.65%25 identity in 194 aa overlap)%3B Q9L146|SC6D11.09 putative oxidoreductase (similarity with SDR family) from Streptomyces coelicolor (343 aa)%2C FASTA scores: opt: 346%2C E(): 1.6e-12%2C (30.4%25 identity in 283 aa overlap)%3B Q9HSR4|YUSZ1|VNG0115G oxidoreductase from Halobacterium sp. strain NRC-1 (260 aa)%2C FASTA scores: opt: 338%2C E(): 3.7e-12%2C (33.85%25 identity in 248 aa overlap)%3B etc. C-terminus also similar to Mycobacterium tuberculosis proteins Q10783|YF43_MYCTU|Rv1543|MTCY48.22c putative oxidoreductase (341 aa)%2C FASTA scores: opt: 787%2C E(): 1.2e-37%2C (39.8%25 identity in 319 aa overlap)%3B O06413|Rv0547c|MTCY25D10.26c hypothetical 31.8 KDA protein (294 aa)%2C FASTA scores: opt: 565%2C E(): 4.7e-25%2C (36.8%25 identity in 242 aa overlap)%3B O53398|Rv1050|MTV017.03 oxidoreductase (SDR family) (301 aa)%2C FASTA scores: opt: 436%2C E(): 1.1e-17%2C (32.2%25 identity in 292 aa overlap). N-terminus (aa 1-320) is similar to P37693|HETM_ANASP polyketide synthase hetM from Anabaena sp. (506 aa)%2C FASTA scores: opt: 188%2C E(): 1.3e-07%2C (27.7%25 identity in 361 aa overlap)%3B so certainly a multi-domain enzyme. Seems to belong to the short-chain dehydrogenases/reductases (SDR) family. Note that this ORF corresponds to the gene ORF2|Q11197 (see Yuan et al.%2C 1995)%2C but longer 266 aa%2C due to use of a more upstream start site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=acrA1;locus_tag=Rv3391;product=Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1;protein_id=CCP46212.1;transl_table=11
AL123456.3	EMBL	gene	3807574	3808437	.	-	.	ID=gene-Rv3392c;Name=cmaA1;gbkey=Gene;gene=cmaA1;gene_biotype=protein_coding;locus_tag=Rv3392c
AL123456.3	EMBL	CDS	3807574	3808437	.	-	0	ID=cds-CCP46213.1;Parent=gene-Rv3392c;Dbxref=EnsemblGenomes-Gn:Rv3392c,EnsemblGenomes-Tr:CCP46213,GOA:P9WPB7,InterPro:IPR003333,InterPro:IPR029063,PDB:1KP9,PDB:1KPG,PDB:1KPH,NCBI_GP:CCP46213.1;Name=CCP46213.1;Note=Rv3392c%2C (MTV004.50)%2C len: 287 aa. CmaA1%2Ccyclopropane mycolic acid synthase 1%2C characterized in 1995 as CFA1_MYCTU|Q11195|CMAA1|CMA1 cyclopropane-fatty-acyl-phospholipid synthase 1 (see citations below). Highly similar to Mycobacterium tuberculosis proteins MTCY20H10.23c (58.7%25 identity in 286 aa overlap)%3B MTCY20H10.24c (68.6%25 identity)%3B MTCY20H10.25c (73.5%25 identity)%3B MTCY20H10.26c (57.0%25 identity)%3B and MTCY20G9.30c (55.7%25 identity). Also highly similar to Q9CBK3|MMAA4|ML1903 methyl mycolic acid synthases from Mycobacterium leprae (298 aa)%2C FASTA scores: opt: 1098%2CE(): 1e-63%2C (57.0%25 identity in 286 aa overlap). Equivalent to AAK44898|MT0672 from Mycobacterium tuberculosis strain CDC1551 (317 aa) but shorter 30 aa and with some differences in residues between the proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cmaA1;locus_tag=Rv3392c;product=Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1);protein_id=CCP46213.1;transl_table=11
AL123456.3	EMBL	gene	3808461	3809387	.	+	.	ID=gene-Rv3393;Name=iunH;gbkey=Gene;gene=iunH;gene_biotype=protein_coding;locus_tag=Rv3393
AL123456.3	EMBL	CDS	3808461	3809387	.	+	0	ID=cds-CCP46214.1;Parent=gene-Rv3393;Dbxref=EnsemblGenomes-Gn:Rv3393,EnsemblGenomes-Tr:CCP46214,GOA:O50418,InterPro:IPR001910,InterPro:IPR023186,UniProtKB/TrEMBL:O50418,NCBI_GP:CCP46214.1;Name=CCP46214.1;Note=Rv3393%2C (MTV004.51)%2C len: 308 aa. Probable iunH%2Cnucleoside hydrolase%2C similar to others e.g. Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa)%2C FASTA scores: opt: 497%2C E(): 6e-24%2C (34.3%25 identity in 312 aa overlap)%3B Q27546|IUNH_CRIFA from Crithidia fasciculata (314 aa)%2CFASTA scores: opt: 475%2C E(): 1.4e-22%2C (31.45%25 identity in 318 aa overlap)%3B Q9CK67|IUNH from Pasteurella multocida (310 aa)%2C FASTA scores: opt: 464%2C E(): 6.9e-22%2C (30.9%25 identity in 314 aa overlap)%3B Q9A549|CC2615 from Caulobacter crescentus (323 aa)%2C FASTA scores: opt: 464%2C E(): 7.2e-22%2C(37.85%25 identity in 280 aa overlap)%3B etc. Note that also similar to BAB34113|ECS0690 (alias AAG54985|YBEK) putative tRNA synthetase from Escherichia coli strain O157:H7 (311 aa)%2C FASTA scores: opt: 483%2C E(): 4.5e-23%2C (33.0%25 identity in 315 aa overlap). The active site histidine is conserved.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=iunH;locus_tag=Rv3393;product=Probable nucleoside hydrolase IunH (purine nucleosidase);protein_id=CCP46214.1;transl_table=11
AL123456.3	EMBL	gene	3809442	3811025	.	-	.	ID=gene-Rv3394c;Name=Rv3394c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3394c
AL123456.3	EMBL	CDS	3809442	3811025	.	-	0	ID=cds-CCP46215.1;Parent=gene-Rv3394c;Dbxref=EnsemblGenomes-Gn:Rv3394c,EnsemblGenomes-Tr:CCP46215,GOA:O50419,InterPro:IPR001126,InterPro:IPR017961,InterPro:IPR017963,UniProtKB/TrEMBL:O50419,NCBI_GP:CCP46215.1;Name=CCP46215.1;Note=Rv3394c%2C (MTV004.52c)%2C len: 527 aa. Hypothetical protein%2C with some similarity to various bacterial proteins e.g. BAB51085|MLR4427 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (545 aa)%2C FASTA scores: opt: 267%2CE(): 2.8e-08%2C (26.5%25 identity in 509 aa overlap)%3B BAB48362|MLR0866 DNA damage inducible protein P from Rhizobium loti (Mesorhizobium loti) (438 aa)%2C FASTA scores: opt: 245%2C E(): 4.6e-07%2C (25.5%25 identity in 290 aa overlap)%3B Q9S292|SCI11.27c hypothetical protein from Streptomyces coelicolor (322 aa)%2C FASTA scores: opt: 202%2C E(): 0.00012%2C(28.5%25 identity in 323 aa overlap)%3B etc. Also similarity with P95102|DINP|RV3056|MTCY22D7.25c hypothetical protein from Mycobacterium tuberculosis (346 aa)%2C FASTA scores: opt: 211%2C E(): 3.9e-05%2C (26.45%25 identity in 306 aa overlap). Equivalent to AAK47838 from Mycobacterium tuberculosis strain CDC1551 (492 aa) but longer 35 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3394c;product=Conserved hypothetical protein;protein_id=CCP46215.1;transl_table=11
AL123456.3	EMBL	gene	3811022	3811636	.	-	.	ID=gene-Rv3395c;Name=Rv3395c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3395c
AL123456.3	EMBL	CDS	3811022	3811636	.	-	0	ID=cds-CCP46216.1;Parent=gene-Rv3395c;Dbxref=EnsemblGenomes-Gn:Rv3395c,EnsemblGenomes-Tr:CCP46216,GOA:P9WKZ9,NCBI_GP:CCP46216.1;Name=CCP46216.1;Note=Rv3395c%2C (MTCY78.33)%2C len: 204 aa. Conserved hypothetical protein%2C with some similarity with RECA proteins (recombinases A) e.g. P16238|RECA_THIFE from Thiobacillus ferrooxidans (346 aa)%2C FASTA scores: opt: 131%2CE(): 1.1%2C (31.45%25 identity in 140 aa overlap)%3B Q59560|RECA_MYCSM from Mycobacterium smegmatis (349 aa)%2CFASTA scores: opt: 121%2C E(): 4.4%2C (30.25%25 identity in 129 aa overlap)%3B etc. Note that shortened since first submission to avoid overlap with Rv3395A. Equivalent to AAK47839 from Mycobacterium tuberculosis strain CDC1551 (227 aa) but shorter 23 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3395c;product=Conserved hypothetical protein;protein_id=CCP46216.1;transl_table=11
AL123456.3	EMBL	gene	3811719	3812345	.	+	.	ID=gene-Rv3395A;Name=Rv3395A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3395A
AL123456.3	EMBL	CDS	3811719	3812345	.	+	0	ID=cds-CCP46217.1;Parent=gene-Rv3395A;Dbxref=EnsemblGenomes-Gn:Rv3395A,EnsemblGenomes-Tr:CCP46217,UniProtKB/TrEMBL:Q6MWX4,NCBI_GP:CCP46217.1;Name=CCP46217.1;Note=Rv3395A%2C len: 208 aa. Probable membrane protein%2Cwith potential transmembrane stretches from aa 7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C putative lipoprotein from Streptomyces coelicolor (258 aa)%2C FASTA scores: opt: 107%2C E(): 7.4%2C (34.05%25 identity in 94 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3395A;product=Probable membrane protein;protein_id=CCP46217.1;transl_table=11
AL123456.3	EMBL	gene	3812501	3814078	.	-	.	ID=gene-Rv3396c;Name=guaA;gbkey=Gene;gene=guaA;gene_biotype=protein_coding;locus_tag=Rv3396c
AL123456.3	EMBL	CDS	3812501	3814078	.	-	0	ID=cds-CCP46218.1;Parent=gene-Rv3396c;Dbxref=EnsemblGenomes-Gn:Rv3396c,EnsemblGenomes-Tr:CCP46218,GOA:P9WMS7,InterPro:IPR001674,InterPro:IPR004739,InterPro:IPR014729,InterPro:IPR017926,InterPro:IPR022310,InterPro:IPR022955,InterPro:IPR025777,InterPro:IPR029062,NCBI_GP:CCP46218.1;Name=CCP46218.1;Note=Rv3396c%2C (MTCY78.32)%2C len: 525 aa. Probable guaA%2Cgmp synthase (see citation below)%2C equivalent to P46810|GUAA_MYCLE|ML0395|B1620_C2_205 GMP synthase [glutamine-hydrolyzing] from Mycobacterium leprae (529 aa)%2CFASTA scores: opt: 2992%2C E(): 8.5e-168%2C (86.85%25 identity in 525 aa overlap). Also highly similar to others e.g. O52831|GUAA_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (524 aa)%2C FASTA scores: opt: 2636%2C E(): 5.9e-147%2C (76.2%25 identity in 521 aa overlap)%3B Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa)%2CFASTA scores: opt: 2451%2C E(): 4.1e-136%2C (71.55%25 identity in 513 aa overlap)%3B Q9KF78|GUAA_BACHD from Bacillus Halodurans (513 aa)%2C FASTA scores: opt: 1819%2C E(): 4.1e-99%2C (52.55%25 identity in 510 aa overlap)%3B etc. Contains PS00442 Glutamine amidotransferases class-I active site. Belongs to the type-1 glutamine amidotransferase family in the N-terminal section. And belongs to the GMP synthase family in the C-terminal section.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=guaA;inference=protein motif:PROSITE:PS00442;locus_tag=Rv3396c;product=Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase);protein_id=CCP46218.1;transl_table=11
AL123456.3	EMBL	gene	3814090	3814998	.	-	.	ID=gene-Rv3397c;Name=phyA;gbkey=Gene;gene=phyA;gene_biotype=protein_coding;gene_synonym=crtB;locus_tag=Rv3397c
AL123456.3	EMBL	CDS	3814090	3814998	.	-	0	ID=cds-CCP46219.1;Parent=gene-Rv3397c;Dbxref=EnsemblGenomes-Gn:Rv3397c,EnsemblGenomes-Tr:CCP46219,GOA:P9WHP3,InterPro:IPR002060,InterPro:IPR008949,InterPro:IPR017828,InterPro:IPR019845,NCBI_GP:CCP46219.1;Name=CCP46219.1;Note=Rv3397c%2C (MTCY78.31)%2C len: 302 aa. Probable phyA (alternate gene name: crtB)%2C phytoene synthase%2C similar to many others e.g. Q9X7V5|SC6A5.09 from Streptomyces coelicolor (312 aa)%2C FASTA scores: opt: 791%2C E(): 2.8e-43%2C(48.25%25 identity in 286 aa overlap)%3B Q9RW07|DR0862 from Deinococcus radiodurans (325 aa)%2C FASTA scores: opt: 482%2CE(): 1.5e-23%2C (35.25%25 identity in 292 aa overlap)%3B Q9JRU9|NMB1168|NMB1130 from Neisseria meningitidis (serogroup B) (290 aa)%2C FASTA scores: opt: 446%2C E(): 2.8e-21%2C (34.25%25 identity in 260 aa overlap)%3B P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419 aa)%2C FASTA scores: opt: 431%2C E(): 3.4e-20%2C (33.0%25 identity in 288 aa overlap)%3B etc. Also similar to Q9JUF5|NMA1339 putative poly-isoprenyl transferase from Neisseria meningitidis (serogroup A) (290 aa)%2C FASTA scores: opt: 450%2C E(): 1.6e-21%2C (34.6%25 identity in 260 aa overlap). And similar to crtB|O05424 phytoene synthase from Mycobacterium marinum (319 aa)%2C blastp scores: 113%2C E%3D 6e-24%2C Identities %3D 89/283 (31%25) (see citation below). Contains PS01045 Squalene and phytoene synthases signature 2. Belongs to the phytoene/squalene synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=phyA;inference=protein motif:PROSITE:PS01045;locus_tag=Rv3397c;product=Probable phytoene synthase PhyA;protein_id=CCP46219.1;transl_table=11
AL123456.3	EMBL	gene	3815027	3816106	.	-	.	ID=gene-Rv3398c;Name=idsA1;gbkey=Gene;gene=idsA1;gene_biotype=protein_coding;gene_synonym=idsA;locus_tag=Rv3398c
AL123456.3	EMBL	CDS	3815027	3816106	.	-	0	ID=cds-CCP46220.1;Parent=gene-Rv3398c;Dbxref=EnsemblGenomes-Gn:Rv3398c,EnsemblGenomes-Tr:CCP46220,GOA:P9WKH1,InterPro:IPR000092,InterPro:IPR008949,InterPro:IPR017446,NCBI_GP:CCP46220.1;Name=CCP46220.1;Note=Rv3398c%2C (MTCY78.30)%2C len: 359 aa. Probable idsA1%2Cgeranylgeranyl pyrophosphate synthetase (GGPP synthetase) including: dimethylallyltransferase %2Cgeranyltranstransferase%2C and farnesyltranstransferase. Most similar to AE000797_3|O26156|Q53479 bifunctional short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrop (325 aa)%2C FASTA scores: opt: 605%2C E(): 0%2C(37.1%25 identity in 329 aa overlap)%3B homology suggests ATG at 30121 or TTG at 30145 to be the initiation codon. Contains PS00444 Polyprenyl synthetases signature 2. Belongs to the FPP/GGPP synthetases family%3B belongs to a family that groups together FPP synthetase%2C GGPP synthetase and hexaprenyl pyrophosphate synthetase. Note that previously known as idsA.;gbkey=CDS;gene=idsA1;inference=protein motif:PROSITE:PS00444;locus_tag=Rv3398c;product=Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase): dimethylallyltransferase (prenyltransferase) (geranyl-diphosphate synthase) + geranyltranstransferase (farnesyl-diphosphate synthase) (farnesyl-pyrophosphate synthetase) (farnesyl diphosphate synthetase) (FPP synthetase) + farnesyltranstransferase (geranylgeranyl-diphosphate synthase);protein_id=CCP46220.1;transl_table=11
AL123456.3	EMBL	gene	3816129	3817175	.	+	.	ID=gene-Rv3399;Name=Rv3399;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3399
AL123456.3	EMBL	CDS	3816129	3817175	.	+	0	ID=cds-CCP46221.1;Parent=gene-Rv3399;Dbxref=EnsemblGenomes-Gn:Rv3399,EnsemblGenomes-Tr:CCP46221,GOA:P9WFH1,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP46221.1;Name=CCP46221.1;Note=Rv3399%2C (MTCY78.29c)%2C len: 348 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C similar to other Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c (367 aa)%2C FASTA scores: opt: 1188%2C E(): 7.7e-69%2C (60.05%25 identity in 308 aa overlap)%3B MTCY31.21c (38.0%25 identity in 308 aa overlap)%2C MTV041_5%2CMTCY4C12_14%2C MTY13D12_21%2C MTV043_22%2C MTCY210_44%2C MTCI5_19%2CMTCI5_20%2C MTV035_9%2C MTCY180_22%2C MTCY31_23%2C MTY13D12_1%2CMTCY180_29%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3399;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP46221.1;transl_table=11
AL123456.3	EMBL	gene	3817239	3818027	.	+	.	ID=gene-Rv3400;Name=Rv3400;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3400
AL123456.3	EMBL	CDS	3817239	3818027	.	+	0	ID=cds-CCP46222.1;Parent=gene-Rv3400;Dbxref=EnsemblGenomes-Gn:Rv3400,EnsemblGenomes-Tr:CCP46222,GOA:P9WKZ7,InterPro:IPR006439,InterPro:IPR010976,InterPro:IPR023198,InterPro:IPR023214,NCBI_GP:CCP46222.1;Name=CCP46222.1;Note=Rv3400%2C (MTCY78.28c)%2C len: 262 aa. Probable hydrolase%2C strongly equivalent to Q49741|YY00_MYCLE|ML0393|B1620_F3_119 hypothetical 28.6 KDA protein from Mycobacterium leprae (261 aa)%2C FASTA scores: opt: 1293%2C E(): 2.2e-71%2C (74.45%25 identity in 262 aa overlap). Similar to several various proteins (notably hydrolases) e.g. Q9L2I7|SCF42.32 putative hydrolase from Streptomyces coelicolor (246 aa)%2C FASTA scores: opt: 888%2CE(): 7.7e-47%2C (56.35%25 identity in 245 aa overlap)%3B Q9EX06|2SCG38.13 putative hydrolase from Streptomyces coelicolor (238 aa)%2C FASTA scores: opt: 195%2C E(): 8.1e-05%2C(29.5%25 identity in 234 aa overlap)%3B Q9I5X4|PA0562 probable hydrolase from Pseudomonas aeruginosa (224 aa)%2C FASTA scores: opt: 190%2C E(): 0.00015%2C (27.8%25 identity in 248 aa overlap)%3B O06995|PGMB_BACSU|YVDM putative beta-phosphoglucomutase from Bacillus subtilis (226 aa)%2CFASTA scores: opt: 190%2C E(): 0.00016%2C (33.9%25 identity in 245 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa)%2C FASTA scores: opt: 413%2C E(): 2e-17%2C (34.9%25 identity in 238 aa overlap). Interestingly%2C note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3400;product=Probable hydrolase;protein_id=CCP46222.1;transl_table=11
AL123456.3	EMBL	gene	3818042	3820402	.	+	.	ID=gene-Rv3401;Name=Rv3401;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3401
AL123456.3	EMBL	CDS	3818042	3820402	.	+	0	ID=cds-CCP46223.1;Parent=gene-Rv3401;Dbxref=EnsemblGenomes-Gn:Rv3401,EnsemblGenomes-Tr:CCP46223,GOA:P9WN13,InterPro:IPR005194,InterPro:IPR005195,InterPro:IPR005196,InterPro:IPR008928,InterPro:IPR011013,InterPro:IPR012341,InterPro:IPR017045,NCBI_GP:CCP46223.1;Name=CCP46223.1;Note=Rv3401%2C (MTCY78.27c)%2C len: 786 aa. Conserved protein%2C may be an hydrolase or a transferase%2C equivalent to Q49736|ML0392|B1620_F1_30 hypothetical 88.1 KDA protein from Mycobacterium leprae (792 aa)%2C FASTA scores: opt: 4820%2C E(): 0%2C (91.45%25 identity in 782 aa overlap). Also highly similar to Q9L2I8|SCF42.31c putative glycosyl transferase from Streptomyces coelicolor (792 aa)%2C FASTA scores: opt: 3060%2C E(): 2.9e-179%2C (59.25%25 identity in 785 aa overlap)%3B and similar to others e.g. Q9K109|NMB0390 maltose phosphorylase from Neisseria meningitidis (serogroup B) (752 aa)%2C FASTA scores: opt: 980%2C E(): 3.5e-52%2C (29.2%25 identity in 774 aa overlap)%3B Q9JSW8|MAPA|NMA2098 putative maltose phosphorylase from Neisseria meningitidis (serogroup A) (752 aa)%2C FASTA scores: opt: 956%2C E(): 1e-50%2C (28.4%25 identity in 764 aa overlap)%3B O06993|YVDK_BACSU hypothetical 88.3 KDA protein (belongs to family 65 of glycosyl hydrolases) from Bacillus subtilis (757 aa)%2C FASTA scores: opt: 926%2C E(): 6.9e-49%2C(28.5%25 identity in 754 aa overlap)%3B Q9CF04|MAPA maltosephosphorylase from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (751 aa)%2C FASTA scores: opt: 907%2C E(): 1e-47%2C (26.95%25 identity in 753 aa overlap)%3B P77154|YCJT_ECOLI|B1316 hypothetical 84.9 KDA protein (belongs to family 65 of glycosyl hydrolases) from Escherichia coli strain K12 (755 aa)%2C FASTA scores: opt: 392%2C E(): 2.9e-16%2C (27.5%25 identity in 774 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa)%2C (27.2%25 identity in 802 aa overlap)%3B note that Rv3400 and Rv3401 are similar to beginning and end of Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx. 270 aa missing from the middle.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3401;product=Conserved protein;protein_id=CCP46223.1;transl_table=11
AL123456.3	EMBL	gene	3820653	3821891	.	-	.	ID=gene-Rv3402c;Name=Rv3402c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3402c
AL123456.3	EMBL	CDS	3820653	3821891	.	-	0	ID=cds-CCP46224.1;Parent=gene-Rv3402c;Dbxref=EnsemblGenomes-Gn:Rv3402c,EnsemblGenomes-Tr:CCP46224,GOA:P9WGJ7,InterPro:IPR000653,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,NCBI_GP:CCP46224.1;Name=CCP46224.1;Note=Rv3402c%2C (MTCY78.26)%2C len: 412 aa. Conserved hypothetical protein%2C probably involved in cell process%2Csimilar to various proteins generally involved in extracellular compounds (lipopolysaccharide O-antigen) biosynthesis e.g. O68392|RFBE perosamine synthetase from Brucella melitensis (367 aa)%2C FASTA scores: opt: 420%2C E(): 1.2e-19%2C (26.15%25 identity in 375 aa overlap)%3B Q9L6C1 3%2C4-dehydratase-like protein from Streptomyces antibioticus (393 aa)%2C FASTA scores: opt: 419%2C E(): 1.5e-19%2C (30.65%25 identity in 385 aa overlap)%3B Q9RR26|OLENI dehydratase from Streptomyces antibioticus (393 aa)%2C FASTA scores: opt: 416%2CE(): 2.3e-19%2C (30.65%25 identity in 385 aa overlap)%3B O33942 eryciv protein from Saccharopolyspora erythraea (Streptomyces erythraeus) (401 aa)%2C FASTA scores: opt: 410%2CE(): 5.6e-19%2C (31.75%25 identity in 362 aa overlap)%3B Q9UZI4|ASPB-LIKE1|PAB0774 aspartate aminotransferase (ASPB-LIKE1) from Pyrococcus abyssi (366 aa)%2C FASTA scores: opt: 402%2C E(): 1.7e-18%2C (27.05%25 identity in 377 aa overlap)%3B O88001|WLBC putative amino-sugar biosynthesis protein from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (366 aa)%2C FASTA scores: opt: 394%2C E(): 5.6e-18%2C (26.8%25 identity in 347 aa overlap)%3B Q45378|BPLC DNA for lipopolysaccharide biosynthesis from Bordetella pertussis (366 aa)%2C FASTA scores: opt: 393%2C E(): 6.5e-18%2C(26.8%25 identity in 347 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3402c;product=Conserved hypothetical protein;protein_id=CCP46224.1;transl_table=11
AL123456.3	EMBL	gene	3822262	3823863	.	-	.	ID=gene-Rv3403c;Name=Rv3403c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3403c
AL123456.3	EMBL	CDS	3822262	3823863	.	-	0	ID=cds-CCP46225.1;Parent=gene-Rv3403c;Dbxref=EnsemblGenomes-Gn:Rv3403c,EnsemblGenomes-Tr:CCP46225,GOA:P9WKZ5,NCBI_GP:CCP46225.1;Name=CCP46225.1;Note=Rv3403c%2C (MTCY78.25)%2C len: 533 aa. Hypothetical unknown protein%2C but some weak similarity to Q9KJP2 hypothetical 54.9 KDA protein from Myxococcus xanthus (504 aa)%2C FASTA scores: opt: 157%2C E(): 0.011%2C (24.1%25 identity in 548 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3403c;product=Hypothetical protein;protein_id=CCP46225.1;transl_table=11
AL123456.3	EMBL	gene	3823880	3824584	.	-	.	ID=gene-Rv3404c;Name=Rv3404c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3404c
AL123456.3	EMBL	CDS	3823880	3824584	.	-	0	ID=cds-CCP46226.1;Parent=gene-Rv3404c;Dbxref=EnsemblGenomes-Gn:Rv3404c,EnsemblGenomes-Tr:CCP46226,GOA:P9WKZ3,InterPro:IPR002376,InterPro:IPR015518,NCBI_GP:CCP46226.1;Name=CCP46226.1;Note=Rv3404c%2C (MTCY78.24)%2C len: 234 aa. Conserved hypothetical protein%2C some similarity to several methionyl-tRNA formyltransferases e.g. BAB51418|MLL4854 from Rhizobium loti (Mesorhizobium loti) (317 aa)%2C FASTA scores: opt: 210%2C E(): 1.7e-06%2C (27.55%25 identity in 178 aa overlap)%3B P94463|FMT_BACSU from Bacillus subtilis (317 aa)%2CFASTA scores: opt: 199 %2CE(): 8.8e-06%2C (28.25%25 identity in 177 aa overlap)%3B O51091||FMT_BORBU|BB0064 from Borrelia burgdorferi (Lyme disease spirochete) (312 aa)%2C FASTA scores: opt: 187%2C E(): 5.2e-05%2C (30.2%25 identity in 192 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3404c;product=Conserved hypothetical protein;protein_id=CCP46226.1;transl_table=11
AL123456.3	EMBL	gene	3824702	3825268	.	-	.	ID=gene-Rv3405c;Name=Rv3405c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3405c
AL123456.3	EMBL	CDS	3824702	3825268	.	-	0	ID=cds-CCP46227.1;Parent=gene-Rv3405c;Dbxref=EnsemblGenomes-Gn:Rv3405c,EnsemblGenomes-Tr:CCP46227,GOA:P9WMC3,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,InterPro:IPR023772,NCBI_GP:CCP46227.1;Name=CCP46227.1;Note=Rv3405c%2C (MTCY78.23)%2C len: 188 aa. Possible transcriptional regulator%2C showing weak similarity to other bacterial regulatory proteins e.g. Q9KE70|BH0987 from Bacillus halodurans (203 aa)%2C FASTA scores: opt: 168%2C E(): 0.0016%2C (34.8%25 identity in 92 aa overlap)%3B Q9A5F7|CC2493 Caulobacter crescentus (204 aa)%2C FASTA scores: opt: 160%2CE(): 0.0051%2C (32.6%25 identity in 89 aa overlap)%3B Q9RDR0|SC4A7.02 from Streptomyces coelicolor (227 aa)%2CFASTA scores: opt: 159%2C E(): 0.0064%2C (37.0%25 identity in 189 aa overlap)%3B etc. Also some similarity to hypothetical Mycobacterium tuberculosis regulatory proteins e.g. O05858|Rv3208|MTCY07D11.18c%2C MTCI125_6%2C MTCY7D11_18%2CMTCY10G2_30%3B etc. Contains potential helix-turn-helix motif from aa 39-60 (+2.97 SD).;gbkey=CDS;locus_tag=Rv3405c;product=Possible transcriptional regulatory protein;protein_id=CCP46227.1;transl_table=11
AL123456.3	EMBL	gene	3825330	3826217	.	+	.	ID=gene-Rv3406;Name=Rv3406;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3406
AL123456.3	EMBL	CDS	3825330	3826217	.	+	0	ID=cds-CCP46228.1;Parent=gene-Rv3406;Dbxref=EnsemblGenomes-Gn:Rv3406,EnsemblGenomes-Tr:CCP46228,GOA:P9WKZ1,InterPro:IPR003819,PDB:4FFA,NCBI_GP:CCP46228.1;Name=CCP46228.1;Note=Rv3406%2C (MTCY78.22c)%2C len: 295 aa. Probable dioxygenase%2C highly similar to Q9WWU|ATSK putative alpha-ketoglutarate dependent dioxygenase from Pseudomonas putida (301 aa)%2C FASTA scores: opt: 994%2C E(): 3.9e-57%2C(53.7%25 identity in 283 aa overlap)%3B Q9I6U1|PA0193 hypothetical protein from Pseudomonas aeruginosa (300 aa)%2CFASTA scores: opt: 1024%2C E(): 4.4e-59%2C (53.65%25 identity in 287 aa overlap)%3B Q9HX81|TAUD|PA3935 taurine dioxygenase from Pseudomonas aeruginosa (277 aa)%2C FASTA scores: opt: 599%2C E(): 1.4e-31%2C (39.35%25 identity in 277 aa overlap)%3B and similar to other dioxygenases e.g. AAG54718|TAUD (alias BAB33845|ECS0422) taurine dioxygenase 2-oxoglutarate-dependent from Escherichia coli strain O157:H7 (283 aa)%2C FASTA scores: opt: 595%2C E(): 2.5e-31%2C(38.1%25 identity in 281 aa overlap)%3B etc. Belongs to the TfdA family of dioxygenases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3406;product=Probable dioxygenase;protein_id=CCP46228.1;transl_table=11
AL123456.3	EMBL	gene	3826252	3826551	.	+	.	ID=gene-Rv3407;Name=vapB47;gbkey=Gene;gene=vapB47;gene_biotype=protein_coding;locus_tag=Rv3407
AL123456.3	EMBL	CDS	3826252	3826551	.	+	0	ID=cds-CCP46229.1;Parent=gene-Rv3407;Dbxref=EnsemblGenomes-Gn:Rv3407,EnsemblGenomes-Tr:CCP46229,GOA:P9WF23,InterPro:IPR006442,NCBI_GP:CCP46229.1;Name=CCP46229.1;Note=Rv3407%2C (MTCY78.21c)%2C len: 99 aa. Possible vapB47%2Cantitoxin%2C part of toxin-antitoxin (TA) operon with Rv3408%2Csee Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK46285|MT2013 (90 aa)%2C FASTA scores: opt: 160%2C E(): 0.00021%2C (37.1%25 identity in 89 aa overlap)%3B O50412|Rv3385c|MTV004.43c (102 aa)%2C FASTA scores: opt: 155%2C E(): 0.00051%2C (41.05%25 identity in 78 aa overlap)%2C MTCY19H5.26%2C MTCY20H10.07%2C MTI376.09c%2CMTCY427.21%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapB47;locus_tag=Rv3407;product=Possible antitoxin VapB47;protein_id=CCP46229.1;transl_table=11
AL123456.3	EMBL	gene	3826548	3826958	.	+	.	ID=gene-Rv3408;Name=vapC47;gbkey=Gene;gene=vapC47;gene_biotype=protein_coding;locus_tag=Rv3408
AL123456.3	EMBL	CDS	3826548	3826958	.	+	0	ID=cds-CCP46230.1;Parent=gene-Rv3408;Dbxref=EnsemblGenomes-Gn:Rv3408,EnsemblGenomes-Tr:CCP46230,GOA:P9WF49,InterPro:IPR002716,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP46230.1;Name=CCP46230.1;Note=Rv3408%2C (MTCY78.20c)%2C len: 136 aa. Possible vapC47%2Ctoxin%2C part of toxin-antitoxin (TA) operon with Rv3407%2Ccontains PIN domain%2C see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50411|Rv3384c|MTV004.42c (130 aa)%2C FASTA scores: opt: 243%2C E(): 1.7e-09%2C (35.1%25 identity in 131 aa overlap)%3B P95252|Rv1962c|MTCY09F9.02 (135 aa)%2C FASTA scores: opt: 191%2C E(): 5e-06%2C (35.5%25 identity in 138 aa overlap)%2C etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=vapC47;locus_tag=Rv3408;product=Possible toxin VapC47. Contains PIN domain.;protein_id=CCP46230.1;transl_table=11
AL123456.3	EMBL	gene	3826991	3828727	.	-	.	ID=gene-Rv3409c;Name=choD;gbkey=Gene;gene=choD;gene_biotype=protein_coding;locus_tag=Rv3409c
AL123456.3	EMBL	CDS	3826991	3828727	.	-	0	ID=cds-CCP46231.1;Parent=gene-Rv3409c;Dbxref=EnsemblGenomes-Gn:Rv3409c,EnsemblGenomes-Tr:CCP46231,GOA:P9WMV9,InterPro:IPR006076,InterPro:IPR007867,NCBI_GP:CCP46231.1;Name=CCP46231.1;Note=Rv3409c%2C (MTCY78.19)%2C len: 578 aa. ChoD%2C cholesterol oxidase%2C equivalent to Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) putative cholesterol oxidase from Mycobacterium leprae (569 aa)%2C FASTA scores: opt: 3510%2CE(): 3.8e-198%2C (88.6%25 identity in 569 aa overlap). Belongs to the GMC oxidoreductases family. Cofactor: FAD flavoprotein. Contains PS00017 ATP/GTP-binding site motif A.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=choD;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3409c;product=Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase);protein_id=CCP46231.1;transl_table=11
AL123456.3	EMBL	gene	3828783	3829910	.	-	.	ID=gene-Rv3410c;Name=guaB3;gbkey=Gene;gene=guaB3;gene_biotype=protein_coding;locus_tag=Rv3410c
AL123456.3	EMBL	CDS	3828783	3829910	.	-	0	ID=cds-CCP46232.1;Parent=gene-Rv3410c;Dbxref=EnsemblGenomes-Gn:Rv3410c,EnsemblGenomes-Tr:CCP46232,GOA:P9WKI5,InterPro:IPR001093,InterPro:IPR005992,InterPro:IPR013785,NCBI_GP:CCP46232.1;Name=CCP46232.1;Note=Rv3410c%2C (MTCY78.18)%2C len: 375 aa. Probable guaB3%2Cinosine-5'-monophosphate (imp) dehydrogenase%2C equivalent to Q49721|YY10_MYCLE|ML0388|B1620_C2_193 hypothetical 38.9 KDA protein from Mycobacterium leprae (375 aa)%2C FASTA scores: opt: 2182%2C E(): 9.5e-122%2C (90.6%25 identity in 373 aa overlap). Highly similar to Q9RHY9 GUAB ORF genes for imp dehydrogenase%2C hypothetical protein from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (376 aa)%2C FASTA scores: opt: 1490%2C E(): 7.6e-81%2C (61.0%25 identity in 382 aa overlap)%3B Q9L0I6|SCD63.03 putative inosine-5'-monophosphate dehydrogenase from Streptomyces coelicolor (374 aa)%2C FASTA scores: opt: 1275%2C E(): 3.8e-68%2C (52.95%25 identity in 372 aa overlap)%3B P73853|GUAB|SLR1722 imp dehydrogenase subunit from Synechocystis sp. strain PCC 6803 (387 aa)%2C FASTA scores: opt: 882%2C E(): 6.7e-45%2C (41.3%25 identity in 373 aa overlap)%3B and similar to other inosine-5'-monophosphate dehydrogenases e.g. P44334|IMDH_HAEIN|GUAB|HI0221 from Haemophilus influenzae (488 aa)%2C FASTA scores: opt: 267%2CE(): 1.8e-08%2C (34.25%25 identity in 216 aa overlap)%3B etc. Also highly similar to the C-terminus of Q50753|GUAA/B homology to Mycobacterium leprae GUAA (fragment) from Mycobacterium tuberculosis (130 aa)%2C FASTA scores: opt: 506%2C E(): 4.6e-23%2C (85.05%25 identity in 87 aa overlap). Similar to other eukaryotic and prokaryotic IMPDH and to GMP reductase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=guaB3;locus_tag=Rv3410c;product=Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD);protein_id=CCP46232.1;transl_table=11
AL123456.3	EMBL	gene	3829930	3831519	.	-	.	ID=gene-Rv3411c;Name=guaB2;gbkey=Gene;gene=guaB2;gene_biotype=protein_coding;locus_tag=Rv3411c
AL123456.3	EMBL	CDS	3829930	3831519	.	-	0	ID=cds-CCP46233.1;Parent=gene-Rv3411c;Dbxref=EnsemblGenomes-Gn:Rv3411c,EnsemblGenomes-Tr:CCP46233,GOA:P9WKI7,InterPro:IPR000644,InterPro:IPR001093,InterPro:IPR005990,InterPro:IPR013785,InterPro:IPR015875,NCBI_GP:CCP46233.1;Name=CCP46233.1;Note=Rv3411c%2C (MTCY78.17)%2C len: 529 aa. Probable guaB2%2Cinosine-5'-monophosphate (imp) dehydrogenase%2C equivalent to Q49729|IMDH_MYCLE|GUAB|ML0387|B1620_C3_238 inosine-5'-monophosphate dehydrogenase from Mycobacterium leprae (529 aa)%2C FASTA scores: opt: 3154%2C E(): 4.4e-165%2C(92.45%25 identity in 529 aa overlap). Highly similar to other inosine-5'-monophosphate dehydrogenases e.g. Q9RHZ0|GUAB from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (506 aa)%2C FASTA scores: opt: 2284%2C E(): 1.5e-117%2C (67.9%25 identity in 505 aa overlap)%3B Q9L0I7|SCD63.02 from Streptomyces coelicolor (501 aa)%2CFASTA scores: opt: 2178%2C E(): 9e-112%2C (67.2%25 identity in 491 aa overlap)%3B O67820|IMDH_AQUAE|GUAB|AQ_2023 from Aquifex aeolicus (490 aa)%2C FASTA scores: opt: 1820%2C E(): 3.2e-92%2C (58.1%25 identity in 487 aa overlap)%3B etc. Also similar to Q50716|YY10_MYCTU|Rv3410c|MT3518|MTCY78.18 hypothetical 38.9 KDA protein from Mycobacterium tuberculosis (38.6%25 identity in 158 aa overlap). Contains PS00487 imp dehydrogenase / GMP reductase signature. Similar to other eukaryotic and prokaryotic IMPDH and to GMP reductase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=guaB2;inference=protein motif:PROSITE:PS00487;locus_tag=Rv3411c;product=Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD);protein_id=CCP46233.1;transl_table=11
AL123456.3	EMBL	gene	3831726	3832136	.	+	.	ID=gene-Rv3412;Name=Rv3412;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3412
AL123456.3	EMBL	CDS	3831726	3832136	.	+	0	ID=cds-CCP46234.1;Parent=gene-Rv3412;Dbxref=EnsemblGenomes-Gn:Rv3412,EnsemblGenomes-Tr:CCP46234,NCBI_GP:CCP46234.1;Name=CCP46234.1;Note=Rv3412%2C (MTCY78.16c)%2C len: 136 aa. Hypothetical protein%2C strongly similar to Q49742|YY12_MYCLE|ML0386|B1620_F3_131 hypothetical 15.3 KDA protein from Mycobacterium leprae (137 aa)%2C FASTA scores: opt: 933%2C E(): 6.3e-52%2C (93.4%25 identity in 136 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv3412;product=Conserved hypothetical protein;protein_id=CCP46234.1;transl_table=11
AL123456.3	EMBL	gene	3832146	3833045	.	-	.	ID=gene-Rv3413c;Name=Rv3413c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3413c
AL123456.3	EMBL	CDS	3832146	3833045	.	-	0	ID=cds-CCP46235.1;Parent=gene-Rv3413c;Dbxref=EnsemblGenomes-Gn:Rv3413c,EnsemblGenomes-Tr:CCP46235,GOA:P9WJ71,PDB:3VEP,NCBI_GP:CCP46235.1;Name=CCP46235.1;Note=Rv3413c%2C (MTCY78.16)%2C len: 299 aa. Unknown ala-%2Cpro-rich protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3413c;product=Unknown alanine and proline rich protein;protein_id=CCP46235.1;transl_table=11
AL123456.3	EMBL	gene	3833038	3833676	.	-	.	ID=gene-Rv3414c;Name=sigD;gbkey=Gene;gene=sigD;gene_biotype=protein_coding;locus_tag=Rv3414c
AL123456.3	EMBL	CDS	3833038	3833676	.	-	0	ID=cds-CCP46236.1;Parent=gene-Rv3414c;Dbxref=EnsemblGenomes-Gn:Rv3414c,EnsemblGenomes-Tr:CCP46236,GOA:P9WGG9,InterPro:IPR000838,InterPro:IPR007627,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,PDB:3VEP,PDB:3VFZ,NCBI_GP:CCP46236.1;Name=CCP46236.1;Note=Rv3414c%2C (MTCY78.15)%2C len: 212 aa. Probable sigD%2Calternative RNA polymerase sigma-D factor (see citations below)%2C similar to others (notably from Streptomyces coelicolor) e.g. Q9L0I8|SCD63.01 from Streptomyces coelicolor (195 aa)%2C FASTA scores: opt: 533%2C E(): 9.6e-28%2C(47.25%25 identity in 182 aa overlap)%3B Q9FDS3|ADSA from Streptomyces griseus (258 aa)%2C FASTA scores: opt: 223%2C E(): 1.8e-07%2C (28.95%25 identity in 183 aa overlap)%3B BAB48649|MLL1224 from Rhizobium loti (Mesorhizobium loti) (187 aa)%2C FASTA scores: opt: 202%2C E(): 3.2e-06%2C (30.4%25 identity in 194 aa overlap)%3B P38133|RPOE_STRCO|SIGE|SCE94.07 from Streptomyces coelicolor (176 aa)%2C FASTA scores: opt: 200%2C E(): 4.1e-06%2C(35.25%25 identity in 156 aa overlap)%3B P37978|CNRH_ALCEU from Alcaligenes eutrophus (Ralstonia eutropha)%2C FASTA scores: opt: 197%2C E(): 6.9e-06%2C (30.35%25 identity in 191 aa overlap)%3B etc. C-terminus strongly similar to N-terminal part of Q49727|S1620B|B1620_C3_233 hypothetical 6.2 KDA protein from Mycobacterium leprae (59 aa)%2C FASTA scores: opt: 217%2C E(): 1.3e-07%2C (90.25%25 identity in 41 aa overlap). Belongs to the sigma-70 factor family.;gbkey=CDS;gene=sigD;locus_tag=Rv3414c;product=Probable alternative RNA polymerase sigma-D factor SigD;protein_id=CCP46236.1;transl_table=11
AL123456.3	EMBL	gene	3833694	3834521	.	-	.	ID=gene-Rv3415c;Name=Rv3415c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3415c
AL123456.3	EMBL	CDS	3833694	3834521	.	-	0	ID=cds-CCP46237.1;Parent=gene-Rv3415c;Dbxref=EnsemblGenomes-Gn:Rv3415c,EnsemblGenomes-Tr:CCP46237,UniProtKB/TrEMBL:I6YG27,NCBI_GP:CCP46237.1;Name=CCP46237.1;Note=Rv3415c%2C (MTCY78.14)%2C len: 275 aa. Conserved hypothetical protein%2C equivalent to Q9CCV3|ML0383 hypothetical protein from Mycobacterium leprae (281 aa)%2CFASTA scores: opt: 1278%2C E(): 4.2e-71%2C (73.5%25 identity in 279 aa overlap). Also some similarity with P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26 riboflavin biosynthesis protein R (339 aa)%2C FASTA scores: opt: 143%2CE(): 0.13%2C (28.25%25 identity in 184 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3415c;product=Conserved hypothetical protein;protein_id=CCP46237.1;transl_table=11
AL123456.3	EMBL	gene	3834892	3835200	.	+	.	ID=gene-Rv3416;Name=whiB3;gbkey=Gene;gene=whiB3;gene_biotype=protein_coding;gene_synonym=whmB;locus_tag=Rv3416
AL123456.3	EMBL	CDS	3834892	3835200	.	+	0	ID=cds-CCP46238.1;Parent=gene-Rv3416;Dbxref=EnsemblGenomes-Gn:Rv3416,EnsemblGenomes-Tr:CCP46238,GOA:P9WF41,InterPro:IPR003482,NCBI_GP:CCP46238.1;Name=CCP46238.1;Note=Rv3416%2C (MTCY78.13c)%2C len: 102 aa. WhiB3 (alternate gene name: whmB)%2C WhiB-like regulatory protein (see citations below)%2C similar to WhiB paralogue of Streptomyces coelicolor%2C wblE gene product (85 aa). Equivalent to Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_137 probable transcription factor WHIB3 from Mycobacterium leprae (102 aa)%2C FASTA scores: opt: 657%2C E(): 7.9e-39%2C (86.25%25 identity in 102 aa overlap). Also highly similar to Q9Z6E9|WHIB3 from Mycobacterium smegmatis (96 aa)%2C FASTA scores: opt: 604%2C E(): 3.5e-35%2C (80.4%25 identity in 102 aa overlap)%3B and O88103|WHID|SC6G4.45c|WBLB from Streptomyces coelicolor (112 aa)%2C FASTA scores: opt: 437%2C E(): 1.4e-23%2C (62.5%25 identity in 96 aa overlap). Also similar to O05847|WHIB1|Rv3219|MTCY07D11.07c from Mycobacterium tuberculosis (84 aa)%2C FASTA scores: opt: 215%2C E(): 2.5e-08%2C(44.45%25 identity in 81 aa overlap). Note that primer extension analysis revealed three transcriptional start sites and that expression from the three potential promoters is growth phase-dependent (see Mulder et al.%2C1999). Moreover%2C the transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al.%2C 2000). [4Fe-4S] cluster is degraded by oxygen and reacts with no (See Singh et al.%2C 2007).;gbkey=CDS;gene=whiB3;locus_tag=Rv3416;product=Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster.;protein_id=CCP46238.1;transl_table=11
AL123456.3	EMBL	gene	3835272	3836891	.	-	.	ID=gene-Rv3417c;Name=groEL1;gbkey=Gene;gene=groEL1;gene_biotype=protein_coding;gene_synonym=cpn60_1;locus_tag=Rv3417c
AL123456.3	EMBL	CDS	3835272	3836891	.	-	0	ID=cds-CCP46239.1;Parent=gene-Rv3417c;Dbxref=EnsemblGenomes-Gn:Rv3417c,EnsemblGenomes-Tr:CCP46239,GOA:P9WPE9,InterPro:IPR001844,InterPro:IPR002423,InterPro:IPR018370,InterPro:IPR027409,InterPro:IPR027413,PDB:3M6C,NCBI_GP:CCP46239.1;Name=CCP46239.1;Note=Rv3417c%2C (MTCY78.12)%2C len: 539 aa. GroEL1 (alternate genbe name: cpn60_1)%2C 60 kDa chaperonin 1 (protein cpn60 1) (see citations below)%2C equivalent to P37578|CH61_MYCLE|B1620_C3_228|GROL1|GROEL1|GROEL-1|GROE1|ML0381|B229_ 60 KDA chaperonin 1 from Mycobacterium leprae (537 aa)%2CFASTA scores: opt: 2846%2C E(): 1.5e-154%2C (82.95%25 identity in 539 aa overlap). Also highly similar to others e.g. Q00767|CH61_STRAL|GROL1|GROEL1 from Streptomyces albus G (539 aa)%2C FASTA scores: opt: 2130%2C E(): 8.1e-114%2C (61.9%25 identity in 541 aa overlap)%3B P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces coelicolor (540 aa)%2C FASTA scores: opt: 2119%2C E(): 3.4e-113%2C (61.8%25 identity in 542 aa overlap)%3B etc. Also similar to P06806|CH62_MYCTU|Q48931|Rv0440|MTV037.04|GROL2|GROEL2|GRO EL-2|HSP65 (62.2%25 identity in 527 aa overlap). Contains PS00017 ATP/GTP-binding site motif A%2C PS00296 Chaperonins cpn60 signature. Belongs to the chaperonin (HSP60) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=groEL1;inference=protein motif:PROSITE:PS00296;locus_tag=Rv3417c;product=60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1);protein_id=CCP46239.1;transl_table=11
AL123456.3	EMBL	gene	3836986	3837288	.	-	.	ID=gene-Rv3418c;Name=groES;gbkey=Gene;gene=groES;gene_biotype=protein_coding;gene_synonym=cpn10,mpt57;locus_tag=Rv3418c
AL123456.3	EMBL	CDS	3836986	3837288	.	-	0	ID=cds-CCP46240.1;Parent=gene-Rv3418c;Dbxref=EnsemblGenomes-Gn:Rv3418c,EnsemblGenomes-Tr:CCP46240,GOA:P9WPE5,InterPro:IPR011032,InterPro:IPR018369,InterPro:IPR020818,PDB:1HX5,PDB:1P3H,PDB:1P82,PDB:1P83,NCBI_GP:CCP46240.1;Name=CCP46240.1;Note=Rv3418c%2C (MTCY78.11)%2C len: 100 aa. GroES (alternate gene names: cpn10%2C mpt57)%2C 10 kDa chaperonin (protein cpn10) (see citations below)%2C equivalent to P24301|CH10_MYCLE|MOPB|GROES|CHPA|ML0380|B1620_C3_227|B229 _C3_247 from Mycobacterium leprae (99 aa)%2C FASTA scores: opt: 568%2CE(): 2.1e-31%2C (89.9%25 identity in 99 aa overlap). And also strongly identical to others e.g. O86017|CH10_MYCAV|MOPB|GROES from Mycobacterium avium and Mycobacterium paratuberculosis (99 aa)%2C FASTA scores: opt: 611%2C E(): 2.9e-34%2C (96.95%25 identity in 99 aa overlap)%3B P15020|CH10_MYCBO|MOPB|GROES from Mycobacterium bovis (99 aa)%2C FASTA scores: opt: 596%2C E(): 2.9e-33%2C (98.95%25 identity in 94 aa overlap)%3B P40172|CH10_STRCO|GROES|SC6G4.39 from Streptomyces coelicolor and Streptomyces lividans (102 aa)%2CFASTA scores: opt: 480%2C E(): 1.6e-25%2C (76.75%25 identity in 99 aa overlap)%3B etc. Also identical to MSG10KAG_1%2CMT10KAG_1%2C MTBCGA_1. Contains PS00681 Chaperonins cpn10 signature. Belongs to the GROES chaperonin family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=groES;inference=protein motif:PROSITE:PS00681;locus_tag=Rv3418c;product=10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen);protein_id=CCP46240.1;transl_table=11
AL123456.3	EMBL	gene	3837555	3838589	.	-	.	ID=gene-Rv3419c;Name=gcp;gbkey=Gene;gene=gcp;gene_biotype=protein_coding;locus_tag=Rv3419c
AL123456.3	EMBL	CDS	3837555	3838589	.	-	0	ID=cds-CCP46241.1;Parent=gene-Rv3419c;Dbxref=EnsemblGenomes-Gn:Rv3419c,EnsemblGenomes-Tr:CCP46241,GOA:P9WHT7,InterPro:IPR000905,InterPro:IPR017860,InterPro:IPR017861,InterPro:IPR022450,NCBI_GP:CCP46241.1;Name=CCP46241.1;Note=Rv3419c%2C (MTCY78.10)%2C len: 344 aa. Probable gcp%2Cglycoprotease%2C equivalent to P37969|GCP_MYCLE|GCP|ML0379|U229E|U1620c|B229_C3_246|B1620 _C3_226 probable glycoprotease from Mycobacterium leprae (351 aa)%2CFASTA scores: opt: 1898%2C E(): 2.4e-101%2C (86.1%25 identity in 345 aa overlap). Highly similar to others e.g. O86793|GCP_STRCO|GCP|SC6G4.30 from Streptomyces coelicolor (374 aa)%2C FASTA scores: opt: 1282%2C E(): 4.1e-66%2C (60.45%25 identity in 344 aa overlap)%3B Q9WXZ2|TM0145 from Thermotoga maritima (327 aa)%2C FASTA scores: opt: 867%2C E(): 1.9e-42%2C(45.4%25 identity in 337 aa overlap)%3B P05852|GCP_ECOLI|B3064 from Escherichia coli strain K12 (337 aa)%2C FASTA scores: opt: 838%2C E(): 9e-41%2C (46.55%25 identity in 346 aa overlap)%3B etc. Shows some similarity to Q50707|YY21_MYCTU|Rv3421c|MTCY78.08 (33.9%25 identity in 127 aa overlap). Contains PS01016 Glycoprotease family signature. Belongs to peptidase family M22%3B also known as the glycoprotease family. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;gbkey=CDS;gene=gcp;inference=protein motif:PROSITE:PS01016;locus_tag=Rv3419c;product=Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease);protein_id=CCP46241.1;transl_table=11
AL123456.3	EMBL	gene	3838586	3839062	.	-	.	ID=gene-Rv3420c;Name=rimI;gbkey=Gene;gene=rimI;gene_biotype=protein_coding;locus_tag=Rv3420c
AL123456.3	EMBL	CDS	3838586	3839062	.	-	0	ID=cds-CCP46242.1;Parent=gene-Rv3420c;Dbxref=EnsemblGenomes-Gn:Rv3420c,EnsemblGenomes-Tr:CCP46242,GOA:I6YG32,InterPro:IPR000182,InterPro:IPR006464,InterPro:IPR016181,UniProtKB/TrEMBL:I6YG32,NCBI_GP:CCP46242.1;Name=CCP46242.1;Note=Rv3420c%2C (MTCY78.09)%2C len: 158 aa. Probable rimI%2Cribosomal-protein-alanine acetyltransferase%2C contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Equivalent to C-terminal part of Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa)%2C FASTA scores: opt: 772%2C E(): 2.7e-44%2C (72.1%25 identity in 154 aa overlap). Similar notably to ribosomal-protein-alanine acetyltransferases e.g. Q9AC11|CC0058 from Caulobacter crescentus (150 aa)%2C FASTA scores: opt: 223%2C E(): 4.9e-08%2C(37.5%25 identity in 136 aa overlap)%3B Q9KFD4|BH0547 from Bacillus halodurans (151 aa)%2C FASTA scores: opt: 222%2C E(): 5.8e-08%2C (35.2%25 identity in 142 aa overlap)%3B Q9PG61|XF0441 from Xylella fastidiosa (156 aa)%2C FASTA scores: opt: 207%2CE(): 5.9e-07%2C (32.2%25 identity in 149 aa overlap)%3B Q9HVB7|RIMI|PA4678 from Pseudomonas aeruginosa (150 aa)%2CFASTA scores: opt: 203%2C E(): 1.1e-06%2C (32.45%25 identity in 151 aa overlap)%3B P09453|RIMI_ECOLI|B4373 from Escherichia coli strain K12 (148 aa)%2C FASTA scores: opt: 196%2C E(): 3.1e-06%2C (33.55%25 identity in 149 aa overlap)%3B etc. Belongs to the acetyltransferase family%2C RIMI subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rimI;locus_tag=Rv3420c;product=Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18);protein_id=CCP46242.1;transl_table=11
AL123456.3	EMBL	gene	3839059	3839694	.	-	.	ID=gene-Rv3421c;Name=Rv3421c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3421c
AL123456.3	EMBL	CDS	3839059	3839694	.	-	0	ID=cds-CCP46243.1;Parent=gene-Rv3421c;Dbxref=EnsemblGenomes-Gn:Rv3421c,EnsemblGenomes-Tr:CCP46243,GOA:P9WKY7,InterPro:IPR000905,InterPro:IPR022496,NCBI_GP:CCP46243.1;Name=CCP46243.1;Note=Rv3421c%2C (MTCY78.08)%2C len: 211 aa. Conserved hypothetical protein%2C equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa)%2C FASTA scores: opt: 1000%2C E(): 1.8e-50%2C (75.6%25 identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa)%2C FASTA scores: opt: 453%2C E(): 3.3e-19%2C (48.1%25 identity in 212 aa overlap)%3B Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa)%2C FASTA scores: opt: 248%2C E(): 2e-07%2C (34.3%25 identity in 210 aa overlap)%3B Q9KQK9|VC1989 from Vibrio cholerae (237 aa)%2CFASTA scores: opt: 238%2C E(): 8.2e-07%2C (28.85%25 identity in 208 aa overlap)%3B BAB51966|Mlr5530 from Rhizobium loti (Mesorhizobium loti) (225 aa)%2C FASTA scores: opt: 237%2C E(): 9e-07%2C (35.0%25 identity in 220 aa overlap)%3B etc. Some similarity to upstream Q50709|GCP_MYCTU|Rv3419c|MT3528|MTCY78.10 from Mycobacterium tuberculosis (344 aa)%2C (33.9%25 identity in 127 aa overlap).;gbkey=CDS;locus_tag=Rv3421c;product=Conserved hypothetical protein;protein_id=CCP46243.1;transl_table=11
AL123456.3	EMBL	gene	3839691	3840197	.	-	.	ID=gene-Rv3422c;Name=Rv3422c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3422c
AL123456.3	EMBL	CDS	3839691	3840197	.	-	0	ID=cds-CCP46244.1;Parent=gene-Rv3422c;Dbxref=EnsemblGenomes-Gn:Rv3422c,EnsemblGenomes-Tr:CCP46244,GOA:P9WFS7,InterPro:IPR003442,InterPro:IPR027417,NCBI_GP:CCP46244.1;Name=CCP46244.1;Note=Rv3422c%2C (MTCY78.07)%2C len: 168 aa. Conserved hypothetical protein%2C equivalent to Q49864|YY22_MYCLE|ML0377|U229F|B229_C2_205 hypothetical 17.6 KDA protein from Mycobacterium leprae (161 aa)%2C FASTA scores: opt: 752%2C E(): 8.3e-38%2C (77.4%25 identity in 146 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces coelicolor (148 aa)%2C FASTA scores: opt: 377%2C E(): 1.2e-15%2C(50.85%25 identity in 120 aa overlap)%3B Q9X1W7|TM1632 from Thermotoga maritima (161 aa)%2C FASTA scores: opt: 247%2C E(): 6.2e-08%2C (39.4%25 identity in 137 aa overlap)%3B Q9RRY1|DR2351 from Deinococcus radiodurans (148 aa)%2C FASTA scores: opt: 236%2C E(): 2.6e-07%2C (38.6%25 identity in 127 aa overlap)%3B etc. Contains PS00017 ATP /GTP-binding site motif A.;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3422c;product=Conserved hypothetical protein;protein_id=CCP46244.1;transl_table=11
AL123456.3	EMBL	gene	3840194	3841420	.	-	.	ID=gene-Rv3423c;Name=alr;gbkey=Gene;gene=alr;gene_biotype=protein_coding;locus_tag=Rv3423c
AL123456.3	EMBL	CDS	3840194	3841420	.	-	0	ID=cds-CCP46245.1;Parent=gene-Rv3423c;Dbxref=EnsemblGenomes-Gn:Rv3423c,EnsemblGenomes-Tr:CCP46245,GOA:P9WQA9,InterPro:IPR000821,InterPro:IPR001608,InterPro:IPR009006,InterPro:IPR011079,InterPro:IPR020622,InterPro:IPR029066,PDB:1XFC,NCBI_GP:CCP46245.1;Name=CCP46245.1;Note=Rv3423c%2C (MTCY78.06)%2C len: 408 aa. Alr%2C alanine racemase%2C equivalent to P38056|ALR_MYCLE|ML0375|B229_C3_243 alanine racemase from Mycobacterium leprae (388 aa)%2C FASTA scores: opt: 2160%2C E(): 2.3e-124%2C (84.35%25 identity in 384 aa overlap). Also highly similar to other alanine racemases e.g. Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa)%2CFASTA scores: opt: 2103%2C E(): 6.8e-121%2C (83.6%25 identity in 384 aa overlap)%3B P94967|ALR_MYCSM from Mycobacterium smegmatis (389 aa)%2C FASTA scores: opt: 1721%2C E(): 1.3e-97%2C(67.25%25 identity in 385 aa overlap)%3B O86786|ALR_STRCO|SC6G4.23 from Streptomyces coelicolor (391 aa)%2C FASTA scores: opt: 1041%2C E(): 3.7e-56%2C (47.65%25 identity in 380 aa overlap)%3B etc. Contains Pfam entry PF00842 Alanine racemase. Belongs to the alanine racemase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=alr;locus_tag=Rv3423c;product=Alanine racemase Alr;protein_id=CCP46245.1;transl_table=11
AL123456.3	EMBL	gene	3841714	3842076	.	-	.	ID=gene-Rv3424c;Name=Rv3424c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3424c
AL123456.3	EMBL	CDS	3841714	3842076	.	-	0	ID=cds-CCP46246.1;Parent=gene-Rv3424c;Dbxref=EnsemblGenomes-Gn:Rv3424c,EnsemblGenomes-Tr:CCP46246,NCBI_GP:CCP46246.1;Name=CCP46246.1;Note=Rv3424c%2C (MTCY78.05)%2C len: 120 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3424c;product=Hypothetical protein;protein_id=CCP46246.1;transl_table=11
AL123456.3	EMBL	gene	3842239	3842769	.	+	.	ID=gene-Rv3425;Name=PPE57;gbkey=Gene;gene=PPE57;gene_biotype=protein_coding;locus_tag=Rv3425
AL123456.3	EMBL	CDS	3842239	3842769	.	+	0	ID=cds-CCP46247.1;Parent=gene-Rv3425;Dbxref=EnsemblGenomes-Gn:Rv3425,EnsemblGenomes-Tr:CCP46247,InterPro:IPR000030,NCBI_GP:CCP46247.1;Name=CCP46247.1;Note=Rv3425%2C (MTCY78.04c)%2C len: 176 aa. PPE57%2C Member of the M. tuberculosis PPE family%2C similar to many e.g. O06246|Rv3429|MTCY77.01 (178 aa)%2C FASTA scores: opt: 781%2CE(): 7e-44%2C (69.9%25 identity in 176 aa overlap)%3B and downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa)%2CFASTA scores: opt: 517%2C E(): 1.2e-26%2C (68.0%25 identity in 125 aa overlap)%3B MTV049_11%2C MTCY428_16%2C MTV049_22%2CMTV049_30%2C MTCY261_4%3B etc.;gbkey=CDS;gene=PPE57;locus_tag=Rv3425;product=PPE family protein PPE57;protein_id=CCP46247.1;transl_table=11
AL123456.3	EMBL	gene	3843036	3843734	.	+	.	ID=gene-Rv3426;Name=PPE58;gbkey=Gene;gene=PPE58;gene_biotype=protein_coding;locus_tag=Rv3426
AL123456.3	EMBL	CDS	3843036	3843734	.	+	0	ID=cds-CCP46248.1;Parent=gene-Rv3426;Dbxref=EnsemblGenomes-Gn:Rv3426,EnsemblGenomes-Tr:CCP46248,GOA:Q50702,InterPro:IPR000030,NCBI_GP:CCP46248.1;Name=CCP46248.1;Note=Rv3426%2C (MTCY78.03c)%2C len: 232 aa. PPE58%2C Member of the M. tuberculosis PPE family%2C similar to many e.g. the downstream O06246|Rv3429|MTCY77.01 (178 aa)%2C FASTA scores: opt: 555%2C E(): 6.5e-26%2C (72.0%25 identity in 125 aa overlap)%3B and upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa)%2CFASTA scores: opt: 517%2C E(): 1.1e-23%2C (68.0%25 identity in 125 aa overlap)%3B MTV049_30%2C MTCY3C7_24%2C MTCY428_16%2CMTCY3A2_22%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE58;locus_tag=Rv3426;product=PPE family protein PPE58;protein_id=CCP46248.1;transl_table=11
AL123456.3	EMBL	gene	3843885	3844640	.	-	.	ID=gene-Rv3427c;Name=Rv3427c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3427c
AL123456.3	EMBL	CDS	3843885	3844640	.	-	0	ID=cds-CCP46249.1;Parent=gene-Rv3427c;Dbxref=EnsemblGenomes-Gn:Rv3427c,EnsemblGenomes-Tr:CCP46249,GOA:Q50701,InterPro:IPR002611,InterPro:IPR003593,InterPro:IPR027417,InterPro:IPR028350,NCBI_GP:CCP46249.1;Name=CCP46249.1;Note=Rv3427c%2C (MTCY78.02)%2C len: 251 aa. Possible transposase%2C similar to other e.g. Q9APG8|ORF2 putative transposase subunit 2 from Pseudomonas putida (251 aa)%2CFASTA scores: opt: 479%2C E(): 1.8e-21%2C (34.85%25 identity in 238 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3427c;product=Possible transposase;protein_id=CCP46249.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3843888	3845970	.	-	.	ID=id-AL123456.3:3843888..3845970;Note=IS1532%2C len: 2083 nt. Insertion sequence IS1532.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1532
AL123456.3	EMBL	gene	3844738	3845970	.	-	.	ID=gene-Rv3428c;Name=Rv3428c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3428c
AL123456.3	EMBL	CDS	3844738	3845970	.	-	0	ID=cds-CCP46250.1;Parent=gene-Rv3428c;Dbxref=EnsemblGenomes-Gn:Rv3428c,EnsemblGenomes-Tr:CCP46250,GOA:Q50700,InterPro:IPR001584,InterPro:IPR012337,NCBI_GP:CCP46250.1;Name=CCP46250.1;Note=Rv3428c%2C (MTCY78.01%2C len: 410 aa. Possible transposase insertion sequence%2C similar to others e.g. Q9APG9|ORF1 from Pseudomonas putida (509 aa)%2C FASTA scores: opt: 578%2C E(): 1.1e-29%2C (32.45%25 identity in 376 aa overlap)%3B P55379|Y4BL_RHISN from Rhizobium sp. strain NGR234 (516 aa)%2C FASTA scores: opt: 665%2C E(): 2.7e-35%2C(35.3%25 identity in 391 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3428c;product=Possible transposase;protein_id=CCP46250.1;transl_table=11
AL123456.3	EMBL	gene	3847165	3847701	.	+	.	ID=gene-Rv3429;Name=PPE59;gbkey=Gene;gene=PPE59;gene_biotype=protein_coding;locus_tag=Rv3429
AL123456.3	EMBL	CDS	3847165	3847701	.	+	0	ID=cds-CCP46251.1;Parent=gene-Rv3429;Dbxref=EnsemblGenomes-Gn:Rv3429,EnsemblGenomes-Tr:CCP46251,InterPro:IPR000030,NCBI_GP:CCP46251.1;Name=CCP46251.1;Note=Rv3429%2C (MTCY77.01)%2C len: 178 aa. PPE59%2C Member of the M. tuberculosis PPE family%2C similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa)%2CFASTA scores: opt: 781%2C E(): 1.9e-44%2C (69.9%25 identity in 176 aa overlap)%3B and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa)%2C FASTA scores: opt: 555%2C E(): 1.7e-29%2C (72.0%25 identity in 125 aa overlap) (but diverges at 3' end)%3B etc.;gbkey=CDS;gene=PPE59;locus_tag=Rv3429;product=PPE family protein PPE59;protein_id=CCP46251.1;transl_table=11
AL123456.3	EMBL	gene	3847642	3848805	.	-	.	ID=gene-Rv3430c;Name=Rv3430c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3430c
AL123456.3	EMBL	CDS	3847642	3848805	.	-	0	ID=cds-CCP46252.1;Parent=gene-Rv3430c;Dbxref=EnsemblGenomes-Gn:Rv3430c,EnsemblGenomes-Tr:CCP46252,GOA:I6YC39,InterPro:IPR001584,InterPro:IPR012337,UniProtKB/TrEMBL:I6YC39,NCBI_GP:CCP46252.1;Name=CCP46252.1;Note=Rv3430c%2C (MTCY77.02c)%2C len: 387 aa. Possible IS1540 transposase%2C similar to several e.g. Q49592 transposase from Mycobacterium intracellulare (340 aa)%2C FASTA scores: opt: 1377%2C E(): 1.6e-81%2C (64.2%25 identity in 338 aa overlap)%3B similarity is lost at C-terminus due to possible frameshift after aa 297.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3430c;product=Possible transposase;protein_id=CCP46252.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3847644	3848806	.	-	.	ID=id-AL123456.3:3847644..3848806;Note=IS1540%2C len: 1163 nt. Insertion sequence IS1540.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1540
AL123456.3	EMBL	gene	3849294	3850139	.	-	.	ID=gene-Rv3431c;Name=Rv3431c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3431c
AL123456.3	EMBL	CDS	3849294	3850139	.	-	0	ID=cds-CCP46253.1;Parent=gene-Rv3431c;Dbxref=EnsemblGenomes-Gn:Rv3431c,EnsemblGenomes-Tr:CCP46253,GOA:I6XH73,InterPro:IPR001207,UniProtKB/TrEMBL:I6XH73,NCBI_GP:CCP46253.1;Name=CCP46253.1;Note=Rv3431c%2C (MTCY77.03c)%2C len: 281 aa. Possible truncated transposase for IS1552%2C similar to%2C but shorter than other transposases e.g. P72303 from Rhodococcus opacus (418 aa)%2C FASTA scores: opt: 1509%2C E(): 1.2e-91%2C (80.95%25 identity in 278 aa overlap)%3B Q9AKV5 from Mycobacterium paratuberculosis (395 aa)%2C FASTA scores: opt: 1115%2C E(): 7.8e-66%2C (63.45%25 identity in 268 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3431c;product=Possible transposase (fragment);protein_id=CCP46253.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3849296	3850140	.	-	.	ID=id-AL123456.3:3849296..3850140;Note=IS1552%2C len: 845 nt. Insertion sequence IS1552.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1552
AL123456.3	EMBL	gene	3850372	3851754	.	-	.	ID=gene-Rv3432c;Name=gadB;gbkey=Gene;gene=gadB;gene_biotype=protein_coding;locus_tag=Rv3432c
AL123456.3	EMBL	CDS	3850372	3851754	.	-	0	ID=cds-CCP46254.1;Parent=gene-Rv3432c;Dbxref=EnsemblGenomes-Gn:Rv3432c,EnsemblGenomes-Tr:CCP46254,GOA:I6YG46,InterPro:IPR002129,InterPro:IPR010107,InterPro:IPR015421,InterPro:IPR015424,UniProtKB/TrEMBL:I6YG46,NCBI_GP:CCP46254.1;Name=CCP46254.1;Note=Rv3432c%2C (MTCY77.04c)%2C len: 460 aa. Probable gadB%2Cglutamate decarboxylase%2C similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa)%2C FASTA scores: opt: 1684%2C E(): 6.2e-99%2C (55.35%25 identity in 457 aa overlap)%3B Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa)%2C FASTA scores: opt: 1650%2CE(): 8.9e-97%2C (57.4%25 identity in 446 aa overlap)%3B Q9AQU4|gad from Oryza sativa (Rice) (501 aa)%2C FASTA scores: opt: 1498%2C E(): 3.7e-87%2C (51.6%25 identity in 432 aa overlap)%3B Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa)%2C FASTA scores: opt: 1485%2C E(): 2.5e-86%2C (51.15%25 identity in 437 aa overlap)%3B etc. Belongs to group II decarboxylases (DDC%2C gad%2C HDC and TYRDC).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gadB;locus_tag=Rv3432c;product=Probable glutamate decarboxylase GadB;protein_id=CCP46254.1;transl_table=11
AL123456.3	EMBL	gene	3851792	3853213	.	-	.	ID=gene-Rv3433c;Name=Rv3433c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3433c
AL123456.3	EMBL	CDS	3851792	3853213	.	-	0	ID=cds-CCP46255.1;Parent=gene-Rv3433c;Dbxref=EnsemblGenomes-Gn:Rv3433c,EnsemblGenomes-Tr:CCP46255,GOA:P9WF11,InterPro:IPR000631,InterPro:IPR004443,InterPro:IPR017953,InterPro:IPR029056,NCBI_GP:CCP46255.1;Name=CCP46255.1;Note=Rv3433c%2C (MTCY77.05)%2C len: 473 aa. Conserved protein%2C member of YKL151c/yjeF family%2C equivalent to P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 hypothetical 47.2 KDA protein from Mycobacterium leprae (473 aa)%2C FASTA scores: opt: 2650%2C E(): 5e-136%2C (84.55%25 identity in 473 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa)%2C FASTA scores: opt: 700%2C E(): 1.2e-30%2C (33.7%25 identity in 484 aa overlap)%3B O86783|SC6G4.20c from Streptomyces coelicolor (485 aa)%2C FASTA scores: opt: 563%2C E(): 3.2e-23%2C (48.45%25 identity in 489 aa overlap)%3B Q9LC81 from Arthrobacter sp. Q36 (313 aa)%2C FASTA scores: opt: 553%2C E(): 7.9e-23%2C (44.2%25 identity in 303 aa overlap)%3B etc. Contains Pfam match to entry PF01256 hypothetical UPFOO31 family signature and PF03853 YjeF-related protein N-terminus. Belongs to the UPF0031 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01050;locus_tag=Rv3433c;product=Conserved protein;protein_id=CCP46255.1;transl_table=11
AL123456.3	EMBL	gene	3853215	3853928	.	-	.	ID=gene-Rv3434c;Name=Rv3434c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3434c
AL123456.3	EMBL	CDS	3853215	3853928	.	-	0	ID=cds-CCP46256.1;Parent=gene-Rv3434c;Dbxref=EnsemblGenomes-Gn:Rv3434c,EnsemblGenomes-Tr:CCP46256,GOA:I6YC44,UniProtKB/TrEMBL:I6YC44,NCBI_GP:CCP46256.1;Name=CCP46256.1;Note=Rv3434c%2C (MTCY77.06c)%2C len: 237 aa. Possible conserved transmembrane protein%2C showing some similarity with Q9CGH7|YLDB hypothetical protein from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (258 aa)%2CFASTA scores: opt: 248%2C E(): 1.6e-09%2C (28.8%25 identity in 198 aa overlap)%3B and P94983|Rv1648|MTCY06H11.13 from Mycobacterium tuberculosis (268 aa)%2C FASTA scores: opt: 205%2C E(): 1.2e-06%2C (31.45%25 identity in 194 aa overlap).;gbkey=CDS;locus_tag=Rv3434c;product=Possible conserved transmembrane protein;protein_id=CCP46256.1;transl_table=11
AL123456.3	EMBL	gene	3853939	3854793	.	-	.	ID=gene-Rv3435c;Name=Rv3435c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3435c
AL123456.3	EMBL	CDS	3853939	3854793	.	-	0	ID=cds-CCP46257.1;Parent=gene-Rv3435c;Dbxref=EnsemblGenomes-Gn:Rv3435c,EnsemblGenomes-Tr:CCP46257,GOA:O06252,InterPro:IPR027948,UniProtKB/TrEMBL:O06252,NCBI_GP:CCP46257.1;Name=CCP46257.1;Note=Rv3435c%2C (MTCY77.07c)%2C len: 284 aa. Probable conserved transmembrane protein%2C showing some similarity with P95061|Rv0713|MTCY210.32 hypothetical 33.9 KDA protein from Mycobacterium tuberculosis (313 aa)%2C FASTA scores: opt: 557%2C E(): 1.3e-26%2C (35.8%25 identity in 282 aa overlap)%3B and O32991|MLCB2492.12 from Mycobacterium leprae (95 aa)%2CFASTA scores: opt: 150%2C E(): 0.022%2C (35.3%25 identity in 85 aa overlap). Equivalent to AAK47881 from Mycobacterium tuberculosis strain CDC1551 (312 aa) but shorter 28 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3435c;product=Probable conserved transmembrane protein;protein_id=CCP46257.1;transl_table=11
AL123456.3	EMBL	gene	3855015	3856889	.	-	.	ID=gene-Rv3436c;Name=glmS;gbkey=Gene;gene=glmS;gene_biotype=protein_coding;locus_tag=Rv3436c
AL123456.3	EMBL	CDS	3855015	3856889	.	-	0	ID=cds-CCP46258.1;Parent=gene-Rv3436c;Dbxref=EnsemblGenomes-Gn:Rv3436c,EnsemblGenomes-Tr:CCP46258,GOA:P9WN49,InterPro:IPR001347,InterPro:IPR005855,InterPro:IPR017932,InterPro:IPR029055,NCBI_GP:CCP46258.1;Name=CCP46258.1;Note=Rv3436c%2C (MTCY77.08c)%2C len: 624 aa. Probable glmS%2Cglucosamine--fructose-6-phosphate aminotransferase%2Cequivalent to P40831|GLMS_MYCLE|ML0371|B229_C3_238 glucosamine--fructose-6-phosphate aminotransferase [isomerizing] from Mycobacterium leprae (623 aa)%2C FASTA scores: opt: 3584%2C E(): 4.7e-214%2C (89.3%25 identity in 627 aa overlap). Also highly similar to others e.g. O68956|GLMS_MYCSM from Mycobacterium smegmatis (627 aa)%2CFASTA scores: opt: 3517%2C E(): 6.5e-210%2C (87.25%25 identity in 627 aa overlap)%3B O86781|GLMS_STRCO|SC6G4.18 from Streptomyces coelicolor (614 aa)%2C FASTA scores: opt: 2364%2CE(): 1.3e-138%2C (64.95%25 identity in 625 aa overlap)%3B Q9K1P9|NMB0031 from Neisseria meningitidis (serogroup B) and Q9JWN9|GLMS|NMA0276 from Neisseria meningitidis (serogroup A) (612 aa)%2C FASTA scores: opt: 1445%2C E(): 8.4e-82%2C (43.55%25 identity in 627 aa overlap)%3B etc. Belongs to the type-2 gatase domain in the N-terminal section. Belongs to the sis family%2C GLMS subfamily%2C in the C-terminal section.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glmS;locus_tag=Rv3436c;product=Probable glucosamine--fructose-6-phosphate aminotransferase [isomerizing] GlmS (hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (glucosamine-6-phosphate synthase);protein_id=CCP46258.1;transl_table=11
AL123456.3	EMBL	gene	3856911	3857387	.	+	.	ID=gene-Rv3437;Name=Rv3437;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3437
AL123456.3	EMBL	CDS	3856911	3857387	.	+	0	ID=cds-CCP46259.1;Parent=gene-Rv3437;Dbxref=EnsemblGenomes-Gn:Rv3437,EnsemblGenomes-Tr:CCP46259,GOA:I6YG51,InterPro:IPR018929,UniProtKB/TrEMBL:I6YG51,NCBI_GP:CCP46259.1;Name=CCP46259.1;Note=Rv3437%2C (MTCY77.09)%2C len: 158 aa. Questionable ORF. Possible conserved transmenbrane protein%2C C-terminus similar to N-terminal part of O06345|Rv3482c|MTCY13E12.35c hypothetical 28.5 KDA protein from Mycobacterium tuberculosis (260 aa)%2C FASTA scores: opt: 140%2C E(): 0.1%2C(58.8%25 identity in 34 aa overlap)%3B and Q9XAN5|SC4C6.05c putative membrane protein from Streptomyces (347 aa)%2Ccoelicolor FASTA scores: opt: 112%2C E(): 6.8%2C (50.0%25 identity in 32 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3437;product=Possible conserved transmembrane protein;protein_id=CCP46259.1;transl_table=11
AL123456.3	EMBL	gene	3857397	3858239	.	+	.	ID=gene-Rv3438;Name=Rv3438;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3438
AL123456.3	EMBL	CDS	3857397	3858239	.	+	0	ID=cds-CCP46260.1;Parent=gene-Rv3438;Dbxref=EnsemblGenomes-Gn:Rv3438,EnsemblGenomes-Tr:CCP46260,InterPro:IPR029058,InterPro:IPR029059,UniProtKB/TrEMBL:I6X7B3,NCBI_GP:CCP46260.1;Name=CCP46260.1;Note=Rv3438%2C (MTCY77.10)%2C len: 280 aa. Conserved protein%2Cequivalent to Q9CCV6|ML0370 hypothetical protein from Mycobacterium leprae (289 aa)%2C FASTA scores: opt: 1491%2CE(): 9.2e-81%2C (79.85%25 identity in 283 aa overlap)%3B and highly similar (but shorter 41 aa) to Q49872|B229_F1_20 hypothetical 34.0 KDA protein from Mycobacterium leprae (324 aa)%2C FASTA scores: opt: 1491%2C E(): 1e-80%2C (79.85%25 identity in 283 aa overlap). Shows some similarity to Q9KIU3|LIPA lipase from plasmid pAH114 uncultured bacterium (281 aa)%2C FASTA scores: opt: 168%2C E(): 0.0081%2C (29.3%25 identity in 140 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3438;product=Conserved protein;protein_id=CCP46260.1;transl_table=11
AL123456.3	EMBL	gene	3858259	3859662	.	-	.	ID=gene-Rv3439c;Name=Rv3439c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3439c
AL123456.3	EMBL	CDS	3858259	3859662	.	-	0	ID=cds-CCP46261.1;Parent=gene-Rv3439c;Dbxref=EnsemblGenomes-Gn:Rv3439c,EnsemblGenomes-Tr:CCP46261,UniProtKB/TrEMBL:I6YC49,NCBI_GP:CCP46261.1;Name=CCP46261.1;Note=Rv3439c%2C (MTCY77.11c)%2C len: 467 aa. Conserved hypothetical ala-%2C pro-rich protein%2C similar in part to N-terminal part of Q49853|B229_C1_154 hypothetical 11.2 KDA protein from Mycobacterium leprae (103 aa)%2C FASTA scores: opt: 265%2C E(): 0.0013%2C (51.1%25 identity in 90 aa overlap).;gbkey=CDS;locus_tag=Rv3439c;product=Conserved hypothetical alanine and proline rich protein;protein_id=CCP46261.1;transl_table=11
AL123456.3	EMBL	gene	3859665	3859976	.	-	.	ID=gene-Rv3440c;Name=Rv3440c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3440c
AL123456.3	EMBL	CDS	3859665	3859976	.	-	0	ID=cds-CCP46262.1;Parent=gene-Rv3440c;Dbxref=EnsemblGenomes-Gn:Rv3440c,EnsemblGenomes-Tr:CCP46262,UniProtKB/TrEMBL:O06257,NCBI_GP:CCP46262.1;Name=CCP46262.1;Note=Rv3440c%2C (MTCY77.12c)%2C len: 103 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3440c;product=Hypothetical protein;protein_id=CCP46262.1;transl_table=11
AL123456.3	EMBL	gene	3860024	3861370	.	-	.	ID=gene-Rv3441c;Name=mrsA;gbkey=Gene;gene=mrsA;gene_biotype=protein_coding;locus_tag=Rv3441c
AL123456.3	EMBL	CDS	3860024	3861370	.	-	0	ID=cds-CCP46263.1;Parent=gene-Rv3441c;Dbxref=EnsemblGenomes-Gn:Rv3441c,EnsemblGenomes-Tr:CCP46263,GOA:P9WN41,InterPro:IPR005841,InterPro:IPR005843,InterPro:IPR005844,InterPro:IPR005845,InterPro:IPR005846,InterPro:IPR006352,InterPro:IPR016055,InterPro:IPR016066,NCBI_GP:CCP46263.1;Name=CCP46263.1;Note=Rv3441c%2C (MTCY77.13c)%2C len: 448 aa. Probable mrsA%2Cphosphoglucomutase or phosphomannomutase%2C equivalent to Q49869|URED|B229_C3_234 MRSA protein homolog from Mycobacterium leprae (463 aa)%2C FASTA scores: opt: 2449%2CE(): 6.3e-135%2C (87.65%25 identity in 445 aa overlap)%3B and highly similar (but longer 178 aa) to Q49862|UREC|B229_C2_192 putative urease operon UREC protein from Mycobacterium leprae (288 aa)%2C FASTA scores: opt: 1442%2C E(): 1.3e-76%2C (86.5%25 identity in 267 aa overlap). Highly similar to phospho-sugar mutases e.g. Q53876|SC6G4.14 putative phospho-sugar mutase (similar to phosphomannomutases) from Streptomyces coelicolor (452 aa)%2CFASTA scores: opt: 1710%2C E(): 5e-92%2C (60.45%25 identity in 450 aa overlap)%3B Q9KG46|BH0267 phosphoglucosamine mutase from Bacillus halodurans (447 aa)%2C FASTA scores: opt: 1351%2CE(): 3.5e-71%2C (48.4%25 identity in 444 aa overlap)%3B BAB58323|GLMM phosphoglucosamine-mutase from Staphylococcus aureus subsp. aureus Mu50 (451 aa) and Q99QR5|GLMM(FEMD)|SA1965 phosphoglucosamine-mutase from Staphylococcus aureus subsp. aureus N315. (451 aa)%2C FASTA scores: opt: 1315%2C E(): 4.3e-69%2C (48.45%25 identity in 446 aa overlap)%3B P95685|FEMD|GLMM phosphoglucosamine-mutase (451 aa)%2C FASTA scores: opt: 1310%2C E(): 8.5e-69%2C (48.2%25 identity in 446 aa overlap)%3B P95575|MRSA_PSESY MRSA protein homolog from Pseudomonas syringae (pv. syringae) (447 aa)%2C FASTA scores: opt: 1143%2C E(): 4.2e-59%2C (42.75%25 identity in 447 aa overlap)%3B etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. Belongs to the phosphohexose mutases family.;gbkey=CDS;gene=mrsA;inference=protein motif:PROSITE:PS00710;locus_tag=Rv3441c;product=Probable phospho-sugar mutase / MrsA protein homolog;protein_id=CCP46263.1;transl_table=11
AL123456.3	EMBL	gene	3861495	3861950	.	-	.	ID=gene-Rv3442c;Name=rpsI;gbkey=Gene;gene=rpsI;gene_biotype=protein_coding;locus_tag=Rv3442c
AL123456.3	EMBL	CDS	3861495	3861950	.	-	0	ID=cds-CCP46264.1;Parent=gene-Rv3442c;Dbxref=EnsemblGenomes-Gn:Rv3442c,EnsemblGenomes-Tr:CCP46264,GOA:P9WH25,InterPro:IPR000754,InterPro:IPR014721,InterPro:IPR020568,InterPro:IPR020574,InterPro:IPR023035,NCBI_GP:CCP46264.1;Name=CCP46264.1;Note=Rv3442c%2C (MTCY77.14c)%2C len: 151 aa. rpsI%2C 30S ribosomal protein S9%2C equivalent to P40828|RS9_MYCLE|ML0365|B229_C2_191 30S ribosomal protein S9 (153 aa)%2C FASTA scores: opt: 800%2C E(): 2.1e-42%2C (83.85%25 identity in 155 aa overlap). Also highly similar to others e.g. Q53875|RS9_STRCO|SC6G4.13 from Streptomyces coelicolor (170 aa)%2C FASTA scores: opt: 533%2C E(): 5.7e-26%2C (60.75%25 identity in 135 aa overlap)%3B Q9KGD4|RPSI|BH0169 (BS10) from Bacillus halodurans (130 aa)%2C FASTA scores: opt: 469%2C E(): 3.8e-22%2C (58.65%25 identity in 121 aa overlap)%3B Q9CDG7|RPSI from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (130 aa)%2C FASTA scores: opt: 451%2C E(): 4.9e-21%2C(58.65%25 identity in 121 aa overlap)%3B P07842|RS9_BACST|RPSI from Bacillus stearothermophilus (129 aa)%2C FASTA scores: opt: 448%2C E(): 7.4e-21%2C (54.55%25 identity in 121 aa overlap)%3B etc. Contains PS00360 Ribosomal protein S9 signature. Belongs to the S9P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsI;inference=protein motif:PROSITE:PS00360;locus_tag=Rv3442c;product=30S ribosomal protein S9 RpsI;protein_id=CCP46264.1;transl_table=11
AL123456.3	EMBL	gene	3861947	3862390	.	-	.	ID=gene-Rv3443c;Name=rplM;gbkey=Gene;gene=rplM;gene_biotype=protein_coding;locus_tag=Rv3443c
AL123456.3	EMBL	CDS	3861947	3862390	.	-	0	ID=cds-CCP46265.1;Parent=gene-Rv3443c;Dbxref=EnsemblGenomes-Gn:Rv3443c,EnsemblGenomes-Tr:CCP46265,GOA:P9WHE1,InterPro:IPR005822,InterPro:IPR005823,InterPro:IPR023563,InterPro:IPR023564,NCBI_GP:CCP46265.1;Name=CCP46265.1;Note=Rv3443c%2C (MTCY77.15c)%2C len: 147 aa. rplM%2C 50S ribosomal protein L13%2C equivalent to P38014|RL13_MYCLE|RPLM|ML0364|B229_C3_232 from Mycobacterium leprae (147 aa)%2C FASTA scores: opt: 917%2C E(): 7.5e-53%2C (91.15%25 identity in 147 aa overlap). Also highly similar to others e.g. Q53874|RL13_STRCO|RPLM|SC6G4.12 from Streptomyces coelicolor (147 aa)%2C FASTA scores: opt: 668%2CE(): 1.1e-36%2C (65.5%25 identity in 145 aa overlap)%3B Q9X1G5|RL13_THEMA|RPLM|TM1454 from Thermotoga maritima (149 aa)%2C FASTA scores: opt: 536%2C E(): 4.4e-28%2C (53.65%25 identity in 136 aa overlap)%3B O67722|RL13_AQUAE|RPLM|AQ_1877 from Aquifex aeolicus (144 aa)%2C FASTA scores: opt: 529%2C E(): 1.2e-27%2C (53.2%25 identity in 141 aa overlap)%3B etc. Belongs to the L13P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplM;locus_tag=Rv3443c;product=50S ribosomal protein L13 RplM;protein_id=CCP46265.1;transl_table=11
AL123456.3	EMBL	gene	3862624	3862926	.	-	.	ID=gene-Rv3444c;Name=esxT;gbkey=Gene;gene=esxT;gene_biotype=protein_coding;locus_tag=Rv3444c
AL123456.3	EMBL	CDS	3862624	3862926	.	-	0	ID=cds-CCP46266.1;Parent=gene-Rv3444c;Dbxref=EnsemblGenomes-Gn:Rv3444c,EnsemblGenomes-Tr:CCP46266,InterPro:IPR010310,UniProtKB/TrEMBL:I6YC53,NCBI_GP:CCP46266.1;Name=CCP46266.1;Note=Rv3444c%2C (MTCY77.16c)%2C len: 100 aa. EsxT%2C ESAT-6 like protein (see citation below)%2C equivalent to Q9CCV7|ML0363 possible secreted protein from Mycobacterium leprae (104 aa)%2C FASTA scores: opt: 362%2C E(): 1.1e-18%2C(71.25%25 identity in 73 aa overlap). C-terminal part highly similar to Q49852|B229_C1_150 hypothetical 5.3 KDA protein from Mycobacterium leprae (49 aa)%2C FASTA scores: opt: 227%2CE(): 1.4e-09%2C (68.9%25 identity in 45 aa overlap). Seems to belong to the ESAT6 family.;gbkey=CDS;gene=esxT;locus_tag=Rv3444c;product=Putative ESAT-6 like protein EsxT;protein_id=CCP46266.1;transl_table=11
AL123456.3	EMBL	gene	3862947	3863264	.	-	.	ID=gene-Rv3445c;Name=esxU;gbkey=Gene;gene=esxU;gene_biotype=protein_coding;locus_tag=Rv3445c
AL123456.3	EMBL	CDS	3862947	3863264	.	-	0	ID=cds-CCP46267.1;Parent=gene-Rv3445c;Dbxref=EnsemblGenomes-Gn:Rv3445c,EnsemblGenomes-Tr:CCP46267,InterPro:IPR010310,UniProtKB/TrEMBL:I6Y3I6,NCBI_GP:CCP46267.1;Name=CCP46267.1;Note=Rv3445c%2C (MTCY77.17c)%2C len: 105 aa. EsxU%2C ESAT-6 like protein (see citations below)%2C showing weak similarity to O30373|VCD|PA2257 pyoverdine biosynthesis protein from Pseudomonas aeruginosa (215 aa)%2C FASTA scores: opt: 103%2CE(): 5.6%2C (32.35%25 identity in 133 aa overlap). Seems to belong to the ESAT6 family. Start changed since first submission (-20 aa).;gbkey=CDS;gene=esxU;locus_tag=Rv3445c;product=ESAT-6 like protein EsxU;protein_id=CCP46267.1;transl_table=11
AL123456.3	EMBL	gene	3863317	3864531	.	-	.	ID=gene-Rv3446c;Name=Rv3446c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3446c
AL123456.3	EMBL	CDS	3863317	3864531	.	-	0	ID=cds-CCP46268.1;Parent=gene-Rv3446c;Dbxref=EnsemblGenomes-Gn:Rv3446c,EnsemblGenomes-Tr:CCP46268,InterPro:IPR023840,UniProtKB/TrEMBL:O06263,NCBI_GP:CCP46268.1;Name=CCP46268.1;Note=Rv3446c%2C (MTCY77.18c)%2C len: 404 aa. Hypothetical unknown ala-%2C val-rich protein.;gbkey=CDS;locus_tag=Rv3446c;product=Hypothetical alanine and valine rich protein;protein_id=CCP46268.1;transl_table=11
AL123456.3	EMBL	gene	3864528	3868238	.	-	.	ID=gene-Rv3447c;Name=eccC4;gbkey=Gene;gene=eccC4;gene_biotype=protein_coding;locus_tag=Rv3447c
AL123456.3	EMBL	CDS	3864528	3868238	.	-	0	ID=cds-CCP46269.1;Parent=gene-Rv3447c;Dbxref=EnsemblGenomes-Gn:Rv3447c,EnsemblGenomes-Tr:CCP46269,GOA:P9WNA7,InterPro:IPR002543,InterPro:IPR003593,InterPro:IPR023836,InterPro:IPR023837,InterPro:IPR027417,NCBI_GP:CCP46269.1;Name=CCP46269.1;Note=Rv3447c%2C (MTCY77.19c)%2C len: 1236 aa. EccC4%2C esx conserved component%2C ESX-4 type VII secretion system protein%2C probable membrane protein%2C similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa)%2C FASTA scores: opt: 1186%2C E(): 1.9e-60%2C (42.9%25 identity in 1312 aa overlap)%3B Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa)%2C FASTA scores: opt: 932%2C E(): 9.2e-46%2C (27.2%25 identity in 1374 aa overlap)%3B Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa)%2C FASTA scores: opt: 910%2C E(): 1.5e-44%2C (34.4%25 identity in 1319 aa overlap)%3B Q9KE81|BH0975 hypothetical protein from Bacillus halodurans (1489 aa)%2C FASTA scores: opt: 805%2C E(): 1.9e-38%2C(25.85%25 identity in 1292 aa overlap)%3B etc. The C-terminal region is similar to Q9CDD7|ML0052 (alias O33086|MLCB628.15c) hypothetical protein from Mycobacterium leprae (597 aa)%2C FASTA scores: opt: 850%2C E(): 2.3e-41%2C(35.2%25 identity in 588 aa overlap)%3B and O6973|Rv3871|MTV027.06 hypothetical protein from Mycobacterium tuberculosis (591 aa)%2C FASTA scores: opt: 845%2C E(): 4.3e-41%2C (35.3%25 identity in 586 aa overlap). N-terminal part shows similarity with hypothetical proteins from Mycobacterium tuberculosis e.g. O69735|Rv3870|MTV027.05 (747 aa)%2C FASTA scores: opt: 761%2CE(): 3.6e-36%2C (38.2%25 identity in 746 aa overlap). Equivalent to AAK47893 from Mycobacterium tuberculosis strain CDC1551 (1200 aa) but longer 36 aa. Contains three of PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccC4;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3447c;product=ESX conserved component EccC4. ESX-4 type VII secretion system protein. Probable membrane protein.;protein_id=CCP46269.1;transl_table=11
AL123456.3	EMBL	gene	3868352	3869755	.	+	.	ID=gene-Rv3448;Name=eccD4;gbkey=Gene;gene=eccD4;gene_biotype=protein_coding;locus_tag=Rv3448
AL123456.3	EMBL	CDS	3868352	3869755	.	+	0	ID=cds-CCP46270.1;Parent=gene-Rv3448;Dbxref=EnsemblGenomes-Gn:Rv3448,EnsemblGenomes-Tr:CCP46270,GOA:P9WNQ1,InterPro:IPR006707,InterPro:IPR024962,NCBI_GP:CCP46270.1;Name=CCP46270.1;Note=Rv3448%2C (MTCY77.20)%2C len: 467 aa. EccD4%2C esx conserved component%2C ESX-4 type VII secretion system protein%2C probable integral membrane protein%2C showing some similarity with Q9CD35|ML2529 from Mycobacterium leprae (485 aa)%2C FASTA scores: opt: 371%2C E(): 3.6e-14%2C (27.25%25 identity in 481 aa overlap)%3B and two proteins from Mycobacterium tuberculosis O86362|Rv0290|MTV035.18 (472 aa)%2C FASTA scores: opt: 429%2C E(): 1.6e-17%2C (28.6%25 identity in 479 aa overlap)%3B and O05457|Rv3887c|MTCY15F10.25 (509 aa)%2C FASTA scores: opt: 203%2C E(): 0.00019%2C (25.6%25 identity in 492 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.;gbkey=CDS;gene=eccD4;inference=protein motif:PROSITE:PS00402;locus_tag=Rv3448;product=ESX conserved component EccD4. ESX-4 type VII secretion system protein. Probable integral membrane protein.;protein_id=CCP46270.1;transl_table=11
AL123456.3	EMBL	gene	3869752	3871119	.	+	.	ID=gene-Rv3449;Name=mycP4;gbkey=Gene;gene=mycP4;gene_biotype=protein_coding;locus_tag=Rv3449
AL123456.3	EMBL	CDS	3869752	3871119	.	+	0	ID=cds-CCP46271.1;Parent=gene-Rv3449;Dbxref=EnsemblGenomes-Gn:Rv3449,EnsemblGenomes-Tr:CCP46271,GOA:I6YC58,InterPro:IPR000209,InterPro:IPR015500,InterPro:IPR022398,InterPro:IPR023827,InterPro:IPR023828,InterPro:IPR023834,UniProtKB/TrEMBL:I6YC58,NCBI_GP:CCP46271.1;Name=CCP46271.1;Note=Rv3449%2C (MTCY13E12.02)%2C len: 455 aa. Probable mycP4%2Cmembrane-anchored serine protease (mycosin) (see citation below)%2C similar to hypothetical unknowns or proteases from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK48366|MT3998 subtilase family protein from Mycobacterium tuberculosis strain CDC1551 (411 aa)%2C FASTA scores: opt: 747%2C E(): 3.5e-33%2C (45.65%25 identity in 416 aa overlap)%3B O05461|Rv3883c|MTCY15F10.29 membrane-anchored mycosin MYCP1 (446 aa)%2C FASTA scores: opt: 747%2C E(): 3.8e-33%2C (45.45%25 identity in 451 aa overlap)%3B O53695|Rv0291|MTV035.19 probable membrane-anchored mycosin MYCP2 (461 aa)%2C FASTA scores: opt: 660%2C E(): 1.9e-28%2C (44.0%25 identity in 457 aa overlap)%3B etc. And similar to hypothetical proteases from Mycobacterium leprae e.g. O33076|MLCB628.04|ML0041 hypothetical 45.7 KDA protein (probable secreted protease) (446 aa)%2C FASTA scores: opt: 683%2C E(): 1.1e-29%2C (43.8%25 identity in 450 aa overlap)%3B Q9CD36|ML2528 putative protease (475 aa)%2C FASTA scores: opt: 608%2C E(): 1.3e-25%2C(43.0%25 identity in 451 aa overlap)%3B Q9CBV3|ML1538 possible protease (567 aa)%2C FASTA scores: opt: 389%2C E(): 9.7e-14%2C(33.8%25 identity in 562 aa overlap)%3B etc. Also some similarity to other proteases from several organisms e.g. O31788|APRX alkaline serine protease from Bacillus subtilis (442 aa)%2C FASTA scores: opt: 296%2C E(): 8.3e-09%2C (29.4%25 identity in 313 aa overlap)%3B O86650|SC3C3.17c putative secreted serine protease from Streptomyces coelicolor (450 aa)%2C FASTA scores: opt: 279%2C E(): 7e-08%2C (33.55%25 identity in 343 aa overlap)%3B Q9KBJ7|APRX|BH193 intracellular alkaline serine protease from Bacillus halodurans (444 aa)%2CFASTA scores: opt: 257%2C E(): 1.1e-06%2C (28.65%25 identity in 335 aa overlap)%3B O86642|SC3C3.08 serine protease from Streptomyces coelicolor (413 aa)%2C FASTA scores: opt: 243%2CE(): 5.7e-06%2C (38.25%25 identity in 387 aa overlap)%3B etc. Has putative signal peptide at N-terminus and hydrophobic stretch at C-terminus. Contains three signatures typical of subtilase family: aspartic acid active site (PS00136)%2Chistidine active site (PS00137)%2C and serine active site (PS00138). Belongs to peptidase family S8 (also known as the subtilase family)%2C pyrolysin subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mycP4;inference=protein motif:PROSITE:PS00138;locus_tag=Rv3449;product=Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4);protein_id=CCP46271.1;transl_table=11
AL123456.3	EMBL	gene	3871084	3872496	.	-	.	ID=gene-Rv3450c;Name=eccB4;gbkey=Gene;gene=eccB4;gene_biotype=protein_coding;locus_tag=Rv3450c
AL123456.3	EMBL	CDS	3871084	3872496	.	-	0	ID=cds-CCP46272.1;Parent=gene-Rv3450c;Dbxref=EnsemblGenomes-Gn:Rv3450c,EnsemblGenomes-Tr:CCP46272,GOA:P9WNR1,InterPro:IPR007795,NCBI_GP:CCP46272.1;Name=CCP46272.1;Note=Rv3450c%2C (MTCY13E12.03c)%2C len: 470 aa. EccB4%2C esx conserved component%2C ESX-4 type VII secretion system protein%2C probable membrane protein (possible membrane spanning region near N-terminus). Similar to hypothetical unknowns proteins from Mycobacterium leprae e.g. O33088|MLCB628.17C|ML0054 hypothetical 51.9 KDA protein (putative membrane protein)(481 aa)%2C FASTA scores: opt: 708%2C E(): 6.4e-32%2C (32.9%25 identity in 480 aa overlap)%3B Q9CD29|ML2536 (552 aa)%2C FASTA scores: opt: 394%2C E(): 1.7e-14%2C (33.6%25 identity in 503 aa overlap)%3B etc. Also similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O69734|Rv3869|MTV027.04 (480 aa)%2C FASTA scores: opt: 717%2C E(): 2e-32%2C (32.55%25 identity in 479 aa overlap)%3B O05449|Rv3895c|MTCY15F10.17 (495 aa)%2C FASTA scores: opt: 670%2C E(): 8.3e-30%2C (36.4%25 identity in 475 aa overlap)%3B O5368|Rv0283|MTV035.11 (538 aa)%2C FASTA scores: opt: 467%2C E(): 1.5e-18%2C (36.3%25 identity in 493 aa overlap)%3B etc.;gbkey=CDS;gene=eccB4;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3450c;product=ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein.;protein_id=CCP46272.1;transl_table=11
AL123456.3	EMBL	gene	3872617	3873405	.	+	.	ID=gene-Rv3451;Name=cut3;gbkey=Gene;gene=cut3;gene_biotype=protein_coding;gene_synonym=clp3,culp3;locus_tag=Rv3451
AL123456.3	EMBL	CDS	3872617	3873405	.	+	0	ID=cds-CCP46273.1;Parent=gene-Rv3451;Dbxref=EnsemblGenomes-Gn:Rv3451,EnsemblGenomes-Tr:CCP46273,GOA:P9WP39,InterPro:IPR000675,InterPro:IPR011150,InterPro:IPR029058,NCBI_GP:CCP46273.1;Name=CCP46273.1;Note=Rv3451%2C (MTCY13E12.04)%2C len: 262 aa. Probable cut3%2Ccutinase precursor%2C similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa)%2C FASTA scores: opt: 540%2C E(): 3.5e-24%2C (43.4%25 identity in 219 aa overlap)%3B Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa)%2C FASTA scores: opt: 214%2C E(): 2e-05%2C(31.45%25 identity in 210 aa overlap)%3B Q9Y7G8 from Pyrenopeziza brassicae (203 aa)%2C FASTA scores: opt: 203%2CE(): 8.5e-05%2C (31.05%25 identity in 190 aa overlap)%3B P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa)%2C FASTA scores: opt: 155%2C E(): 0.054%2C (31.65%25 identity in 120 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. the downstream ORF O06319|Rv3452|MTCY13E12.05 hypothetical 23.1 KDA protein (226 aa)%2C FASTA scores: opt: 775%2C E(): 1e-37%2C (58.65%25 identity in 220 aa overlap)%3B Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c probable cutinase precursor (219 aa)%2C FASTA scores: opt: 565%2C E(): 1.3e-25%2C (44.85%25 identity in 223 aa overlap)%3B Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 probable cutinase precursor (217 aa)%2C FASTA scores: opt: 489%2C E(): 3e-21%2C (47.05%25 identity in 221 aa overlap)%3B etc. Equivalent to AAK47897 from Mycobacterium tuberculosis strain CDC1551 (247 aa) but longer 15 aa. Contains cutinase%2C serine active site motif (PS00155). Belongs to the cutinase family. Alternative start possible at 3733. Start changed since first submission (+15 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cut3;inference=protein motif:PROSITE:PS00155;locus_tag=Rv3451;product=Probable cutinase precursor Cut3;protein_id=CCP46273.1;transl_table=11
AL123456.3	EMBL	gene	3873452	3874132	.	+	.	ID=gene-Rv3452;Name=cut4;gbkey=Gene;gene=cut4;gene_biotype=protein_coding;gene_synonym=clp4,culp4;locus_tag=Rv3452
AL123456.3	EMBL	CDS	3873452	3874132	.	+	0	ID=cds-CCP46274.1;Parent=gene-Rv3452;Dbxref=EnsemblGenomes-Gn:Rv3452,EnsemblGenomes-Tr:CCP46274,GOA:O06319,InterPro:IPR000675,InterPro:IPR029058,UniProtKB/TrEMBL:O06319,NCBI_GP:CCP46274.1;Name=CCP46274.1;Note=Rv3452%2C (MTCY13E12.05)%2C len: 226 aa. Probable cut4%2Ccutinase precursor%2C similar to other e.g. Q9KK87 from Mycobacterium avium (220 aa)%2C FASTA scores: opt: 522%2C E(): 7.3e-24%2C (46.6%25 identity in 221 aa overlap)%3B P30272|CUTI_MAGGR|CUT1 from Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) (228 aa)%2C FASTA scores: opt: 205%2C E(): 3.8e-05%2C (29.25%25 identity in 164 aa overlap)%3B Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa)%2C FASTA scores: opt: 204%2C E(): 3.9e-05%2C(33.5%25 identity in 209 aa overlap)%3B etc. Similar to other proteins from Mycobacterium tuberculosis e.g. upstream ORF O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 probable cutinase precursor (247 aa)%2C FASTA scores: opt: 773%2C E(): 1.3e-38%2C (59.35%25 identity in 209 aa overlap)%3B Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c probable cutinase precursor (219 aa)%2C FASTA scores: opt: 704%2C E(): 1.3e-34%2C (53.4%25 identity in 219 aa overlap)%3B etc. Contains PS00155 Cutinase%2C serine active site. Belongs to the cutinase family. Alternative start possible at 4553 in cSCY13E12 but no RBS.;gbkey=CDS;gene=cut4;inference=protein motif:PROSITE:PS00155;locus_tag=Rv3452;product=Probable cutinase precursor Cut4;protein_id=CCP46274.1;transl_table=11
AL123456.3	EMBL	gene	3874404	3874736	.	+	.	ID=gene-Rv3453;Name=Rv3453;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3453
AL123456.3	EMBL	CDS	3874404	3874736	.	+	0	ID=cds-CCP46275.1;Parent=gene-Rv3453;Dbxref=EnsemblGenomes-Gn:Rv3453,EnsemblGenomes-Tr:CCP46275,GOA:O06320,UniProtKB/TrEMBL:O06320,NCBI_GP:CCP46275.1;Name=CCP46275.1;Note=Rv3453%2C (MTCY13E12.06)%2C len: 110 aa. Possible conserved transmembrane protein%2C showing weak similarity with other proteins e.g. Q9F6C3 putative ABC transporter from Propionibacterium thoenii (424 aa)%2C FASTA scores: opt: 104%2C E(): 6.8%2C (40.6%25 identity in 69 aa overlap).;gbkey=CDS;locus_tag=Rv3453;product=Possible conserved transmembrane protein;protein_id=CCP46275.1;transl_table=11
AL123456.3	EMBL	gene	3874822	3876090	.	+	.	ID=gene-Rv3454;Name=Rv3454;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3454
AL123456.3	EMBL	CDS	3874822	3876090	.	+	0	ID=cds-CCP46276.1;Parent=gene-Rv3454;Dbxref=EnsemblGenomes-Gn:Rv3454,EnsemblGenomes-Tr:CCP46276,UniProtKB/TrEMBL:O06321,NCBI_GP:CCP46276.1;Name=CCP46276.1;Note=Rv3454%2C (MTCY13E12.07)%2C len: 422 aa. Probable conserved integral membrane protein%2C showing some similarity to various proteins (generally transporters) e.g. Q9I5C8|PA0811 probable MFS transporter from Pseudomonas aeruginosa (415 aa)%2C FASTA scores: opt: 145%2CE(): 0.13%2C (28.2%25 identity in 188 aa overlap)%3B Q01266|YHYC_PSESN hypothetical protein in HYUC 3'region (ORF 5) (fragment) from Pseudomonas sp. strain NS671 (245 aa)%2C FASTA scores: opt: 130%2C E(): 0.75%2C (24.65%25 identity in 134 aa overlap)%3B Q9I242|PA2073 probable transporter (membrane subunit) from Pseudomonas aeruginosa (476 aa)%2CFASTA scores: opt: 125%2C E(): 2.5%2C (24.6%25 identity in 252 aa overlap)%3B etc. Equivalent to AAK47900 from Mycobacterium tuberculosis strain CDC1551 (562 aa) but shorter 140 aa. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3454;product=Probable conserved integral membrane protein;protein_id=CCP46276.1;transl_table=11
AL123456.3	EMBL	gene	3876052	3876822	.	-	.	ID=gene-Rv3455c;Name=truA;gbkey=Gene;gene=truA;gene_biotype=protein_coding;locus_tag=Rv3455c
AL123456.3	EMBL	CDS	3876052	3876822	.	-	0	ID=cds-CCP46277.1;Parent=gene-Rv3455c;Dbxref=EnsemblGenomes-Gn:Rv3455c,EnsemblGenomes-Tr:CCP46277,GOA:P9WHP9,InterPro:IPR001406,InterPro:IPR020094,InterPro:IPR020095,InterPro:IPR020097,InterPro:IPR020103,NCBI_GP:CCP46277.1;Name=CCP46277.1;Note=Rv3455c%2C (MTCY13E12.08c)%2C len: 256 aa. Probable truA%2C pseudouridine synthase A%2C equivalent to Q9X796|TRUA_MYCLE|ML1955|MLCB1222.25c tRNA pseudouridine synthase a from Mycobacterium leprae (249 aa)%2C FASTA scores: opt: 1345%2C E(): 3.2e-80%2C (77.25%25 identity in 246 aa overlap). Also highly similar to others e.g. O86776|TRUA_STRCO|SC6G4.09 from Streptomyces coelicolor (284 aa)%2C FASTA scores: opt: 595%2C E(): 1.7e-31%2C (49.8%25 identity in 259 aa overlap)%3B Q9RS37|DR2290 from Deinococcus radiodurans (280 aa)%2C FASTA scores: opt: 383%2C E(): 1e-17%2C(41.2%25 identity in 216 aa overlap)%3B Q9PJT0|TRUA_CHLMU|TC0748 from Chlamydia muridarum (267 aa)%2CFASTA scores: opt: 334%2C E(): 1.5e-14%2C (37.65%25 identity in 231 aa overlap)%3B P07649|TRUA_ECOLI|hist|ASUC|LEUK|B2318 from Escherichia coli strain K12 (270 aa)%2C FASTA scores: opt: 315%2C E(): 2.5e-13%2C (33.35%25 identity in 240 aa overlap)%3B etc. Belongs to the TruA family of pseudouridine synthases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=truA;locus_tag=Rv3455c;product=Probable tRNA pseudouridine synthase a TruA (pseudouridylate synthase I) (pseudouridine synthase I) (uracil hydrolyase);protein_id=CCP46277.1;transl_table=11
AL123456.3	EMBL	gene	3876890	3877432	.	-	.	ID=gene-Rv3456c;Name=rplQ;gbkey=Gene;gene=rplQ;gene_biotype=protein_coding;locus_tag=Rv3456c
AL123456.3	EMBL	CDS	3876890	3877432	.	-	0	ID=cds-CCP46278.1;Parent=gene-Rv3456c;Dbxref=EnsemblGenomes-Gn:Rv3456c,EnsemblGenomes-Tr:CCP46278,GOA:P9WHD3,InterPro:IPR000456,NCBI_GP:CCP46278.1;Name=CCP46278.1;Note=Rv3456c%2C (MTCY13E12.09c)%2C len: 180 aa. rplQ%2C 50S ribosomal protein L17%2C equivalent to Q9X797|RL17_MYCLE|ML1956|MLCB1222.26c 50S ribosomal protein L17 from Mycobacterium leprae (170 aa)%2C FASTA scores: opt: 874%2C E(): 9.5e-45%2C (81.85%25 identity in 171 aa overlap). Also highly similar to other e.g. O86775|RL17_STRCO|SC6G4.08 from Streptomyces coelicolor (168 aa)%2C FASTA scores: opt: 609%2C E(): 3.7e-29%2C (60.0%25 identity in 170 aa overlap)%3B BAB47931|MLR0326 from Rhizobium loti (Mesorhizobium loti) (143 aa)%2C FASTA scores: opt: 404%2C E(): 3.7e-17%2C (49.65%25 identity in 139 aa overlap)%3B Q9Z9H5|RL17_THETH|RPLQ from Thermus aquaticus (subsp. thermophilus) (118 aa)%2C FASTA scores: opt: 366%2CE(): 5.5e-15%2C (53.15%25 identity in 111 aa overlap)%3B P02416|RL17_ECOLI|RPLQ|B3294 from Escherichia coli strain K12 (127 aa)%2C FASTA scores: opt: 347%2C E(): 7.6e-14%2C (50.4%25 identity in 119 aa overlap)%3B etc. Belongs to the L17P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rplQ;locus_tag=Rv3456c;product=50S ribosomal protein L17 RplQ;protein_id=CCP46278.1;transl_table=11
AL123456.3	EMBL	gene	3877464	3878507	.	-	.	ID=gene-Rv3457c;Name=rpoA;gbkey=Gene;gene=rpoA;gene_biotype=protein_coding;locus_tag=Rv3457c
AL123456.3	EMBL	CDS	3877464	3878507	.	-	0	ID=cds-CCP46279.1;Parent=gene-Rv3457c;Dbxref=EnsemblGenomes-Gn:Rv3457c,EnsemblGenomes-Tr:CCP46279,GOA:P9WGZ1,InterPro:IPR009025,InterPro:IPR011260,InterPro:IPR011262,InterPro:IPR011263,InterPro:IPR011773,NCBI_GP:CCP46279.1;Name=CCP46279.1;Note=Rv3457c%2C (MTCY13E12.10c)%2C len: 347 aa. Probable rpoA%2C alpha chain of RNA polymerase%2C equivalent to Q9X798|RPOA_MYCLE|ML1957|MLCB1222.27c DNA-directed RNA polymerase alpha from Mycobacterium leprae (347 aa)%2C FASTA scores: opt: 2139%2C E(): 1.3e-123%2C (95.65%25 identity in 347 aa overlap). Also highly similar to others e.g. P72404|RPOA_STRCO|C6G4.07 from Streptomyces coelicolor (340 aa)%2C FASTA scores: opt: 1672%2C E(): 4.7e-95%2C (75.55%25 identity in 348 aa overlap)%3B Q9X4V6|RPOA_STRGT from Streptomyces granaticolor (340 aa)%2C FASTA scores: opt: 1671%2C E(): 5.4e-95%2C (75.55%25 identity in 348 aa overlap)%3B P20429|RPOA_BACSU from Bacillus subtilis (314 aa)%2C FASTA scores: opt: 939%2C E(): 3e-50%2C (48.9%25 identity in 311 aa overlap)%3B etc. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). Belongs to the RNA polymerase alpha chain family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpoA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3457c;product=Probable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed RNA nucleotidyltransferase);protein_id=CCP46279.1;transl_table=11
AL123456.3	EMBL	gene	3878659	3879264	.	-	.	ID=gene-Rv3458c;Name=rpsD;gbkey=Gene;gene=rpsD;gene_biotype=protein_coding;locus_tag=Rv3458c
AL123456.3	EMBL	CDS	3878659	3879264	.	-	0	ID=cds-CCP46280.1;Parent=gene-Rv3458c;Dbxref=EnsemblGenomes-Gn:Rv3458c,EnsemblGenomes-Tr:CCP46280,GOA:P9WH35,InterPro:IPR001912,InterPro:IPR002942,InterPro:IPR005709,InterPro:IPR018079,InterPro:IPR022801,NCBI_GP:CCP46280.1;Name=CCP46280.1;Note=Rv3458c%2C (MTCY13E12.11c)%2C len: 201 aa. rpsD%2C 30S ribosomal protein S4%2C equivalent to Q9X799|RS4_MYCLE|RPSD|ML1958|MLCB1222.28c 30S ribosomal protein S4 from Mycobacterium leprae (201 aa)%2C FASTA scores: opt: 1271%2C E(): 2.2e-73%2C (93.5%25 identity in 201 aa overlap)%3B and P45811|RS4_MYCBO|RPSD from Mycobacterium bovis (131 aa)%2C FASTA scores: opt: 867%2C E(): 4.9e-48%2C(100.0%25 identity in 130 aa overlap). Also highly similar to others e.g. P81288|RS4_BACST|RPSD from Bacillus stearothermophilus (198 aa)%2C FASTA scores: opt: 665%2C E(): 4e-35%2C (52.25%25 identity in 201 aa overlap)%3B Q9K7Z8|RPSD|BH3209 from Bacillus halodurans (200 aa)%2C FASTA scores: opt: 626%2C E(): 1.2e-32%2C (48.75%25 identity in 203 aa overlap)%3B Q9X1I3|RS4_THEMA|RPSD|TM1473 from Thermotoga maritima (209 aa)%2C FASTA scores: opt: 591%2C E(): 2e-30%2C(45.0%25 identity in 209 aa overlap)%3B etc. Contains ribosomal protein S4 signature (PS00632) and ATP/GTP binding site motif A (PS00017). Belongs to the S4P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsD;inference=protein motif:PROSITE:PS00632;locus_tag=Rv3458c;product=30S ribosomal protein S4 RpsD;protein_id=CCP46280.1;transl_table=11
AL123456.3	EMBL	gene	3879273	3879692	.	-	.	ID=gene-Rv3459c;Name=rpsK;gbkey=Gene;gene=rpsK;gene_biotype=protein_coding;locus_tag=Rv3459c
AL123456.3	EMBL	CDS	3879273	3879692	.	-	0	ID=cds-CCP46281.1;Parent=gene-Rv3459c;Dbxref=EnsemblGenomes-Gn:Rv3459c,EnsemblGenomes-Tr:CCP46281,GOA:P9WH65,InterPro:IPR001971,InterPro:IPR018102,InterPro:IPR019981,NCBI_GP:CCP46281.1;Name=CCP46281.1;Note=Rv3459c%2C (MTCY13E12.12c)%2C len: 139 aa. rpsK%2C 30S ribosomal protein S11%2C equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S ribosomal protein S11 from Mycobacterium leprae (138 aa)%2C FASTA scores: opt: 819%2C E(): 7.6e-44%2C (89.95%25 identity in 139 aa overlap)%3B and P45812|RS11_MYCBO 30S ribosomal protein S11 from Mycobacterium bovis (139 aa)%2C FASTA scores: opt: 867%2CE(): 8.4e-47%2C (94.25%25 identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa)%2C FASTA scores: opt: 729%2C E(): 2.6e-38%2C (79.85%25 identity in 139 aa overlap)%3B O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa)%2C FASTA scores: opt: 618%2C E(): 1.7e-31%2C (70.3%25 identity in 128 aa overlap)%3B P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa)%2C FASTA scores: opt: 601%2C E(): 2e-30%2C(69.0%25 identity in 129 aa overlap)%3B etc. Contains ribosomal protein S11 signature (PS00054). Belongs to the S11P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsK;inference=protein motif:PROSITE:PS00054;locus_tag=Rv3459c;product=30S ribosomal protein S11 RpsK;protein_id=CCP46281.1;transl_table=11
AL123456.3	EMBL	gene	3879696	3880070	.	-	.	ID=gene-Rv3460c;Name=rpsM;gbkey=Gene;gene=rpsM;gene_biotype=protein_coding;locus_tag=Rv3460c
AL123456.3	EMBL	CDS	3879696	3880070	.	-	0	ID=cds-CCP46282.1;Parent=gene-Rv3460c;Dbxref=EnsemblGenomes-Gn:Rv3460c,EnsemblGenomes-Tr:CCP46282,GOA:P9WH61,InterPro:IPR001892,InterPro:IPR010979,InterPro:IPR018269,InterPro:IPR019980,InterPro:IPR027437,NCBI_GP:CCP46282.1;Name=CCP46282.1;Note=Rv3460c%2C (MTCY13E12.13c)%2C len: 124 aa. rpsM%2C 30S ribosomal protein S13%2C equivalent to Q9X7A1|RS13_MYCLE|RPSM|ML1960|MLCB1222.30c 30S ribosomal protein S13 from Mycobacterium leprae (124 aa)%2C FASTA scores: opt: 762%2C E(): 1.5e-43%2C (92.75%25 identity in 124 aa overlap)%3B and P45813|RS13_MYCBO|RPSM from Mycobacterium bovis (123 aa)%2C FASTA scores: opt: 727%2C E(): 3e-41%2C (98.25%25 identity in 114 aa overlap). Also highly similar to others e.g. O86773|RS13_STRCO|SC6G4.05 from Streptomyces coelicolor (126 aa)%2C FASTA scores: opt: 631%2C E(): 6.2e-35%2C(73.75%25 identity in 122 aa overlap)%3B Q9RA65|RPS13 from Thermus aquaticus (subsp. thermophilus) (126 aa)%2C FASTA scores: opt: 552%2C E(): 9.8e-30%2C (62.6%25 identity in 123 aa overlap)%3B P20282|RS13_BACSU|RPSM from Bacillus subtilis (120 aa)%2C FASTA scores: opt: 533%2C E(): 1.7e-28%2C (64245%25 identity in 121 aa overlap)%3B etc. Contains ribosomal protein S13 signature (PS00646). Belongs to the S13P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpsM;inference=protein motif:PROSITE:PS00646;locus_tag=Rv3460c;product=30S ribosomal protein S13 RpsM;protein_id=CCP46282.1;transl_table=11
AL123456.3	EMBL	gene	3880286	3880399	.	-	.	ID=gene-Rv3461c;Name=rpmJ;gbkey=Gene;gene=rpmJ;gene_biotype=protein_coding;locus_tag=Rv3461c
AL123456.3	EMBL	CDS	3880286	3880399	.	-	0	ID=cds-CCP46283.1;Parent=gene-Rv3461c;Dbxref=EnsemblGenomes-Gn:Rv3461c,EnsemblGenomes-Tr:CCP46283,GOA:P9WH89,InterPro:IPR000473,NCBI_GP:CCP46283.1;Name=CCP46283.1;Note=Rv3461c%2C (MTCY13E12.14c)%2C len: 37 aa. rpmJ%2C 50S ribosomal protein L36%2C equivalent to P45810|RL36_MYCBO|RPMJ from Mycobacterium bovis (37 aa)%3B and Q9X7A2|RL36_MYCLE|RPMJ|ML1961|MLCB1222.31c 50S ribosomal protein L36 from Mycobacterium leprae (37 aa)%2C FASTA scores: opt: 241%2C E(): 9.7e-14%2C (86.5%25 identity in 37 aa overlap). Also highly similar to others e.g. O86772|RL36_STRCO|SC6G4.04 from Streptomyces coelicolor (37 aa)%2C FASTA scores: opt: 233%2C E(): 4.5e-13%2C (83.8%25 identity in 37 aa overlap)%3B P07841|RL36_BACST|RPMJ from Bacillus stearothermophilus (37 aa)%2C FASTA scores: opt: 214%2C E(): 1.6e-11%2C (72.95%25 identity in 37 aa overlap)%3B P12230|RK36_SPIOL|RPL36 from Spinacia oleracea (Spinach) (37 aa)%2C FASTA scores: opt: 211%2C E(): 2.9e-11%2C (70.25%25 identity in 37 aa overlap)%3B etc. Contains PS00828 Ribosomal protein L36 signature. Belongs to the L36P family of ribosomal proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rpmJ;inference=protein motif:PROSITE:PS00828;locus_tag=Rv3461c;product=50S ribosomal protein L36 RpmJ;protein_id=CCP46283.1;transl_table=11
AL123456.3	EMBL	gene	3880432	3880653	.	-	.	ID=gene-Rv3462c;Name=infA;gbkey=Gene;gene=infA;gene_biotype=protein_coding;locus_tag=Rv3462c
AL123456.3	EMBL	CDS	3880432	3880653	.	-	0	ID=cds-CCP46284.1;Parent=gene-Rv3462c;Dbxref=EnsemblGenomes-Gn:Rv3462c,EnsemblGenomes-Tr:CCP46284,GOA:P9WKK3,InterPro:IPR004368,InterPro:IPR006196,InterPro:IPR012340,InterPro:IPR022967,PDB:3I4O,NCBI_GP:CCP46284.1;Name=CCP46284.1;Note=Rv3462c%2C (MTCY13E12.15c)%2C len: 73 aa. Probable infA%2Cinitiation factor if-1%2C equivalent to P45957|ML1962|INFA translation initiation factor if-1 from Mycobacterium bovis (72 aa) and Mycobacterium leprae (72 aa)%2C FASTA scores: opt: 472%2C E(): 6.6e-28%2C (100.0%25 identity in 72 aa overlap). Also highly similar to others e.g. O54209|IF1_STRCO|INFA|SC6G4.03 from Streptomyces coelicolor (73 aa)%2C FASTA scores: opt: 424%2C E(): 2e-24%2C (84.95%25 identity in 73 aa overlap)%3B O50630|IF1_BACHD|INFA|BH0158 from Bacillus halodurans (71 aa)%2C FASTA scores: opt: 388%2CE(): 8.1e-22%2C (77.8%25 identity in 72 aa overlap)%3B Q9XD14|IF1_LEPIN|INFA from Leptospira interrogans (71 aa)%2CFASTA scores: opt: 376%2C E(): 6e-21%2C (80.0%25 identity in 70 aa overlap)%3B etc. Contains 1 'S1 motif' domain. Belongs to the if-1 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=infA;locus_tag=Rv3462c;product=Probable translation initiation factor if-1 InfA;protein_id=CCP46284.1;transl_table=11
AL123456.3	EMBL	gene	3880907	3881764	.	+	.	ID=gene-Rv3463;Name=Rv3463;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3463
AL123456.3	EMBL	CDS	3880907	3881764	.	+	0	ID=cds-CCP46285.1;Parent=gene-Rv3463;Dbxref=EnsemblGenomes-Gn:Rv3463,EnsemblGenomes-Tr:CCP46285,GOA:I6X7D4,InterPro:IPR011251,InterPro:IPR019922,UniProtKB/TrEMBL:I6X7D4,NCBI_GP:CCP46285.1;Name=CCP46285.1;Note=Rv3463%2C (MTCY13E12.16)%2C len: 285 aa. Conserved protein%2C similar to Q9RDA2|SCE20.23 hypothetical 31.4 KDA protein from Streptomyces coelicolor (290 aa)%2C FASTA scores: opt: 770%2C E(): 2.2e-41%2C (48.6%25 identity in 247 aa overlap)%3B and Q9X7Y1|SC6A5.35 putative oxidoreductase from Streptomyces coelicolor (341 aa)%2C (see blastp results)%2CFASTA scores: opt: 119%2C E(): 2.9%2C (24.1%25 identity in 274 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3463;product=Conserved protein;protein_id=CCP46285.1;transl_table=11
AL123456.3	EMBL	gene	3881837	3882832	.	+	.	ID=gene-Rv3464;Name=rmlB;gbkey=Gene;gene=rmlB;gene_biotype=protein_coding;gene_synonym=rfbB;locus_tag=Rv3464
AL123456.3	EMBL	CDS	3881837	3882832	.	+	0	ID=cds-CCP46286.1;Parent=gene-Rv3464;Dbxref=EnsemblGenomes-Gn:Rv3464,EnsemblGenomes-Tr:CCP46286,GOA:P9WN65,InterPro:IPR001509,InterPro:IPR005888,InterPro:IPR016040,NCBI_GP:CCP46286.1;Name=CCP46286.1;Note=Rv3464%2C (MTCY13E12.17)%2C len: 331 aa. RmlB (alternate gene name: rfbB)%2C dTDP-glucose-4%2C6-dehydratase (see citations below)%2C nearly identical to Q50556|RMLB rhamnose biosynthesis protein from Mycobacterium tuberculosis (329 aa) (previously rfbB%2C now known as rmlB). Equivalent to Q9CBH7|RMLB|ML1964 dTDP-glucose 4%2C6-dehydratase (alias Q9X7A3|RMLB putative dTDP-(glucose or rhamnose)-4%2C6-dehydratase (331 aa)) from Mycobacterium leprae (333 aa)%2C FASTA scores: opt: 1925%2C E(): 1.9e-112%2C(84.0%25 identity in 331 aa overlap). Also highly similar to others e.g. Q9UZH2|RFBB|PAB0785 from Pyrococcus abyssi (333 aa)%2C FASTA scores: opt: 1115%2C E(): 4.2e-62%2C (51.55%25 identity in 322 aa overlap)%3B O27817|MTH1789 from Methanobacterium thermoautotrophicum (336 aa)%2C FASTA scores: opt: 1104%2C E(): 2.1e-61%2C (51.65%25 identity in 331 aa overlap)%3B BAB60064|TVG0950610 from Thermoplasma volcanium (318 aa)%2C FASTA scores: opt: 1102%2C E(): 2.6e-61%2C (49.65%25 identity in 310 aa overlap)%3B etc. Also related to P72050|MTCY13D12.18|RV3784 hypothetical 36.3 KDA protein (similar to galactowaldenases from eukaryotic and prokaryotic origin) from Mycobacterium tuberculosis (326 aa)%2C FASTA scores: E(): 1.4e-26%2C (33.8%25 identity in 320 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rmlB;locus_tag=Rv3464;product=dTDP-glucose 4%2C6-dehydratase RmlB;protein_id=CCP46286.1;transl_table=11
AL123456.3	EMBL	gene	3882834	3883442	.	+	.	ID=gene-Rv3465;Name=rmlC;gbkey=Gene;gene=rmlC;gene_biotype=protein_coding;gene_synonym=rfbC;locus_tag=Rv3465
AL123456.3	EMBL	CDS	3882834	3883442	.	+	0	ID=cds-CCP46287.1;Parent=gene-Rv3465;Dbxref=EnsemblGenomes-Gn:Rv3465,EnsemblGenomes-Tr:CCP46287,GOA:P9WH11,InterPro:IPR000888,InterPro:IPR011051,InterPro:IPR014710,PDB:1PM7,PDB:1UPI,PDB:2IXC,NCBI_GP:CCP46287.1;Name=CCP46287.1;Note=Rv3465%2C (MTCY13E12.18)%2C len: 202 aa. RmlC (alternate gene name: rfbC)%2C dTDP-4-dehydrorhamnose 3%2C5-epimerase (see citations below)%2C nearly identical to O33170|RMLC RMLC protein from Mycobacterium tuberculosis (203 aa)%2C FASTA scores: opt: 1171%2C E(): 2.6e-71%2C (89.5%25 identity in 200 aa overlap) (previously known as rfbC). Equivalent to Q9X7A4|RMLC|ML1965 putative dTDP-4-dehydrorhamnose 3%2C5-epimerase from Mycobacterium leprae (202 aa)%2C FASTA scores: opt: 1072%2C E(): 1.1e-64%2C (75.4%25 identity in 199 aa overlap). Also highly similar to others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis (198 aa)%2C FASTA scores: opt: 671%2C E(): 7e-38%2C (51.3%25 identity in 193 aa overlap)%3B Q9L6C5 from Streptomyces antibioticus (202 aa)%2C FASTA scores: opt: 665%2C E(): 1.8e-37%2C (49.25%25 identity in 197 aa overlap)%3B P29783|STRM_STRGR from Streptomyces griseus (200 aa)%2C FASTA scores: opt: 608%2C E(): 1.2e-33%2C (49.25%25 identity in 201 aa overlap)%3B Q54265|STRM from Streptomyces glaucescens (200 aa)%2C FASTA scores: opt: 603%2C E(): 2.5e-33%2C (46.7%25 identity in 197 aa overlap)%3B etc. Also highly similar to Q9S4D4|TYLJ putative NDP-hexose 3-epimerase from Streptomyces fradiae (205 aa)%2C FASTA scores: opt: 625%2C E(): 8.6e-35%2C (45.9%25 identity in 194 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rmlC;locus_tag=Rv3465;product=dTDP-4-dehydrorhamnose 3%2C5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3%2C5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3%2C5-epimerase);protein_id=CCP46287.1;transl_table=11
AL123456.3	EMBL	gene	3883525	3884193	.	+	.	ID=gene-Rv3466;Name=Rv3466;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3466
AL123456.3	EMBL	CDS	3883525	3884193	.	+	0	ID=cds-CCP46288.1;Parent=gene-Rv3466;Dbxref=EnsemblGenomes-Gn:Rv3466,EnsemblGenomes-Tr:CCP46288,InterPro:IPR003870,NCBI_GP:CCP46288.1;Name=CCP46288.1;Note=Rv3466%2C (MTCY13E12.19)%2C len: 222 aa. Conserved hypothetical ORF in REP13E12 repeat%2C but extending 5' of repeat. Has segment of identity to other REP13E12 ORF's e.g. MTCY336.16%2C MTCI65.15c%2C MTCY09F9.19%2C cMTCY251.14c. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3466;product=Conserved hypothetical protein;protein_id=CCP46288.1;transl_table=11
AL123456.3	EMBL	repeat_region	3883550	3884921	.	+	.	ID=id-AL123456.3:3883550..3884921;Note=REP-8%2C len: 1372 nt. REP13E12%2C copies in Mycobacterium tuberculosis cosmids: cY336 from 14471 to 15821 (approx. 100%25 identity)%3B cY251 from 11693 to 13109 (approx. 100%25 identity)%3B cI65 from 14515 to 15905 (approx 75%25 identity)%3B cI125 from 27240 to 28597 (approx. 65%25 Identity)%3B cY22G8 from 13352 to 14689 (approx. 65%25 identity)%3B and cY9F9 from 9019 to 10451 (approx. 65%25 identity)%3B also nearly identical to EM_BA :MB35021 U35021 Mycobacterium bovis BCG DNA flanking deletion region 3 from 56 to 1466. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=repeat_region
AL123456.3	EMBL	gene	3883964	3884917	.	+	.	ID=gene-Rv3467;Name=Rv3467;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3467
AL123456.3	EMBL	CDS	3883964	3884917	.	+	0	ID=cds-CCP46289.1;Parent=gene-Rv3467;Dbxref=EnsemblGenomes-Gn:Rv3467,EnsemblGenomes-Tr:CCP46289,InterPro:IPR003615,InterPro:IPR003870,UniProtKB/TrEMBL:Q50655,NCBI_GP:CCP46289.1;Name=CCP46289.1;Note=Rv3467%2C (MTCY13E12.20)%2C len: 317 aa. Conserved hypothetical ORF in REP13E12 repeat%2C identical to ORF's from other REP13E12 copies e.g. MTCY251.13c%2C MTCI65.15c%2CMTCY09F9.19%2C cMTCY336.17. Also identical to Mycobacterium bovis Q50655 hypothetical 34.6 kDa protein (317 aa) in identical repeat.;gbkey=CDS;locus_tag=Rv3467;product=Conserved hypothetical protein;protein_id=CCP46289.1;transl_table=11
AL123456.3	EMBL	gene	3884975	3886069	.	-	.	ID=gene-Rv3468c;Name=Rv3468c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3468c
AL123456.3	EMBL	CDS	3884975	3886069	.	-	0	ID=cds-CCP46290.1;Parent=gene-Rv3468c;Dbxref=EnsemblGenomes-Gn:Rv3468c,EnsemblGenomes-Tr:CCP46290,GOA:Q6MWX3,InterPro:IPR001509,InterPro:IPR016040,UniProtKB/TrEMBL:Q6MWX3,NCBI_GP:CCP46290.1;Name=CCP46290.1;Note=Rv3468c%2C (MTCY13E12.21c)%2C len: 364 aa. Possible dTDP-glucose-4%2C6-dehydratase%2C but experimental study shown that the purified protein didn't have dTDP-glucose dehydratase (rmlB) activity (see Ma et al.%2C 2001). Similar to others e.g. O08246|MTME from Streptomyces argillaceus (331 aa)%2C FASTA scores: opt: 238%2C E(): 1.2e-07%2C (29.65%25 identity in 344 aa overlap)%3B Q9LFG7|F4P12_220 from Arabidopsis thaliana (Mouse-ear cress) (433 aa)%2C FASTA scores: opt: 237%2C E(): 1.8e-07%2C (27.25%25 identity in 308 aa overlap)%3B Q9LZI2|F26K9_260 from Arabidopsis thaliana (Mouse-ear cress) (445 aa)%2C FASTA scores: opt: 225%2C E(): 1e-06%2C (25.95%25 identity in 335 aa overlap)%3B etc. Also similar to various enzymes and hypothetical unknowns proteins e.g. BAB48655|MLL1234 UDP-glucose 4-epimerase from Rhizobium loti (Mesorhizobium loti) (307 aa)%2C FASTA scores: opt: 757%2C E(): 4.6e-40%2C (43.4%25 identity in 302 aa overlap). First start taken%2C alternative at 17080 in cSCYY13E12 suggested by similarity. Note that previously known as rmlB3 (see Ma et al.%2C 2001).;gbkey=CDS;locus_tag=Rv3468c;product=Possible dTDP-glucose 4%2C6-dehydratase;protein_id=CCP46290.1;transl_table=11
AL123456.3	EMBL	gene	3886073	3887083	.	-	.	ID=gene-Rv3469c;Name=mhpE;gbkey=Gene;gene=mhpE;gene_biotype=protein_coding;locus_tag=Rv3469c
AL123456.3	EMBL	CDS	3886073	3887083	.	-	0	ID=cds-CCP46291.1;Parent=gene-Rv3469c;Dbxref=EnsemblGenomes-Gn:Rv3469c,EnsemblGenomes-Tr:CCP46291,GOA:O06334,InterPro:IPR000891,InterPro:IPR013785,InterPro:IPR017629,UniProtKB/TrEMBL:O06334,NCBI_GP:CCP46291.1;Name=CCP46291.1;Note=Rv3469c%2C (MTCY13E12.22c)%2C len: 336 aa. Probable mhpE%2C 4-hydroxy-2-oxovalerate aldolase%2C similar to others (principally from Pseudomonas species) e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338 aa)%2C FASTA scores: opt: 615%2C E(): 7.9e-31%2C (37.65%25 identity in 332 aa overlap)%3B Q9X9Q0|NIKB NIKB protein (see Bruntner et al.%2C 1999) from Streptomyces tendae (357 aa)%2C FASTA scores: opt: 571%2C E(): 4.4e-28%2C (34.5%25 identity in 339 aa overlap)%3B P51014|BPHF_PSES1 from Pseudomonas sp. strain KKS102 (352 aa)%2C FASTA scores: opt: 549%2C E(): 9.9e-27%2C(31.2%25 identity in 314 aa overlap)%3B Q51983|CMTG_PSEPU from Pseudomonas putida (350 aa)%2C FASTA scores: opt: 543%2C E(): 2.3e-26%2C (30.7%25 identity in 319 aa overlap)%3B P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa)%2C FASTA scores: opt: 517%2C E(): 9.1e-25%2C (31.75%25 identity in 312 aa overlap)%3B etc. Also similar to P71867|MTCY03C7.22|Rv3534c hypothetical 36.4 KDA protein from Mycobacterium tuberculosis (346 aa)%2C FASTA scores: E(): 7.5e-24%2C (31.9%25 identity in 310 aa overlap).;gbkey=CDS;gene=mhpE;locus_tag=Rv3469c;product=Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA);protein_id=CCP46291.1;transl_table=11
AL123456.3	EMBL	gene	3887144	3888802	.	-	.	ID=gene-Rv3470c;Name=ilvB2;gbkey=Gene;gene=ilvB2;gene_biotype=protein_coding;locus_tag=Rv3470c
AL123456.3	EMBL	CDS	3887144	3888802	.	-	0	ID=cds-CCP46292.1;Parent=gene-Rv3470c;Dbxref=EnsemblGenomes-Gn:Rv3470c,EnsemblGenomes-Tr:CCP46292,GOA:O06335,InterPro:IPR000399,InterPro:IPR011766,InterPro:IPR012000,InterPro:IPR012001,InterPro:IPR029035,InterPro:IPR029061,NCBI_GP:CCP46292.1;Name=CCP46292.1;Note=Rv3470c%2C (MTCY13E12.23c)%2C len: 552 aa. Probable ilvB2%2C acetolactate synthase large subunit%2C similar to others e.g. P73913|ILVG|SLR2088 from Synechocystis sp. strain PCC 6803 (621 aa)%2C FASTA scores: opt: 779%2C E(): 4.5e-39%2C (30.7%25 identity in 567 aa overlap)%3B O78518|ILVB_GUITH from Guillardia theta (Cryptomonas phi) (575 aa)%2C FASTA scores: opt: 742%2C E(): 6.9e-37%2C (28.8%25 identity in 566 aa overlap)%3B Q59950|ILVX from Spirulina platensis (612 aa)%2C FASTA scores: opt: 715%2C E(): 3e-35%2C(28.45%25 identity in 569 aa overlap)%3B etc. Contains thiamine pyrophosphate enzymes signature (PS00187).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvB2;inference=protein motif:PROSITE:PS00187;locus_tag=Rv3470c;product=Probable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS);protein_id=CCP46292.1;transl_table=11
AL123456.3	EMBL	gene	3888808	3889341	.	-	.	ID=gene-Rv3471c;Name=Rv3471c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3471c
AL123456.3	EMBL	CDS	3888808	3889341	.	-	0	ID=cds-CCP46293.1;Parent=gene-Rv3471c;Dbxref=EnsemblGenomes-Gn:Rv3471c,EnsemblGenomes-Tr:CCP46293,GOA:O06336,InterPro:IPR006045,InterPro:IPR011051,InterPro:IPR014710,UniProtKB/TrEMBL:O06336,NCBI_GP:CCP46293.1;Name=CCP46293.1;Note=Rv3471c%2C (MTCY13E12.24c)%2C len: 177 aa. Conserved hypothetical protein%2C similar to Q59013|MJ1618 hypothetical protein from Methanococcus jannaschii (125 aa)%2C FASTA scores: opt: 262%2C E(): 1.2e-09%2C (39.05%25 identity in 105 aa overlap)%3B and O26452|MTH352 conserved protein from Methanobacterium thermoautotrophicum (131 aa)%2C FASTA scores: opt: 222%2C E(): 3.8e-07%2C (35.05%25 identity in 117 aa overlap). Equivalent to AAK47934 from Mycobacterium tuberculosis strain CDC1551 (184 aa) but shorter 7 aa.;gbkey=CDS;locus_tag=Rv3471c;product=Conserved hypothetical protein;protein_id=CCP46293.1;transl_table=11
AL123456.3	EMBL	gene	3889362	3889868	.	+	.	ID=gene-Rv3472;Name=Rv3472;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3472
AL123456.3	EMBL	CDS	3889362	3889868	.	+	0	ID=cds-CCP46294.1;Parent=gene-Rv3472;Dbxref=EnsemblGenomes-Gn:Rv3472,EnsemblGenomes-Tr:CCP46294,UniProtKB/TrEMBL:I6YG83,NCBI_GP:CCP46294.1;Name=CCP46294.1;Note=Rv3472%2C (MTCY13E12.25)%2C len: 168 aa. Conserved protein%2C showing some similarity to other proteins e.g. Q9ZAT9|DPSH daunorubicin biosynthesis enzyme from Streptomyces peucetius (194 aa)%2C FASTA scores: opt: 181%2CE(): 6.8e-05%2C (30.7%25 identity in 127 aa overlap)%3B Q53879 DAUH/E from Streptomyces sp. C5 (151 aa)%2C FASTA scores: opt: 168%2C E(): 0.00038%2C (29.25%25 identity in 127 aa overlap)%3B and Q9L4U3|AKNV from Streptomyces galilaeus (144 aa)%2C FASTA scores: opt: 122%2C E(): 0.36%2C (31.25%25 identity in 129 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3472;product=Conserved protein;protein_id=CCP46294.1;transl_table=11
AL123456.3	EMBL	gene	3889948	3890733	.	-	.	ID=gene-Rv3473c;Name=bpoA;gbkey=Gene;gene=bpoA;gene_biotype=protein_coding;locus_tag=Rv3473c
AL123456.3	EMBL	CDS	3889948	3890733	.	-	0	ID=cds-CCP46295.1;Parent=gene-Rv3473c;Dbxref=EnsemblGenomes-Gn:Rv3473c,EnsemblGenomes-Tr:CCP46295,GOA:O06338,InterPro:IPR000639,InterPro:IPR029058,UniProtKB/TrEMBL:O06338,NCBI_GP:CCP46295.1;Name=CCP46295.1;Note=Rv3473c%2C (MTCY13E12.26c)%2C len: 261 aa. Possible bpoA%2C peroxidase (non-haem peroxidase)%2C similar to various enzymes or hypothetical unknown proteins e.g. O85849 hypothetical 26.2 KDA protein from Sphingomonas aromaticivorans (247 aa)%2C FASTA scores: opt: 684%2C E(): 4.9e-34%2C (43.8%25 identity in 242 aa overlap)%3B AAK45412|MT1155 hydrolase%2C alpha/beta hydrolase fold family from Mycobacterium tuberculosis strain CDC1551 (311 aa)%2CFASTA scores: opt: 675%2C E(): 2e-33%2C (39.45%25 identity in 256 aa overlap)%3B Q9K3V0|SCD10.27 putative hydrolase from Streptomyces coelicolor (352 aa)%2C FASTA scores: opt: 248%2CE(): 9.7e-08%2C (26.05%25 identity in 261 aa overlap)%3B P29715|BPA2_STRAU|BPOA2 non-haem bromoperoxidase (bromide peroxidase) (277 aa)%2C FASTA scores: opt: 237%2C E(): 3.6e-07%2C(29.45%25 identity in 265 aa overlap)%3B O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase (278 aa)%2C FASTA scores: opt: 236%2C E(): 4.2e-07%2C (29.45%25 identity in 265 aa overlap)%3B AAK62388|T5L19.180 lipase-like protein from Arabidopsis thaliana (Mouse-ear cress) (350 aa)%2C FASTA scores: opt: 236%2C E(): 5.1e-07%2C (26.65%25 identity in 274 aa overlap)%3B etc. Also similar to O06575|BPOB|Rv1123c|MTCY22G8.12c hypothetical 32.5 KDA protein from Mycobacterium tuberculosis (302 aa)%2C FASTA scores: opt: 675%2C E(): 2e-33%2C (39.45%25 identity in 256 aa overlap). Equivalent to AAK47936 from Mycobacterium tuberculosis strain CDC1551 (294 aa) but shorter 33 aa. May have been inactivated or truncated by neighbouring IS6110.;gbkey=CDS;gene=bpoA;locus_tag=Rv3473c;product=Possible peroxidase BpoA (non-haem peroxidase);protein_id=CCP46295.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	3890779	3892133	.	+	.	ID=id-AL123456.3:3890779..3892133;Note=IS6110-16%2C len: 1355 nt. Insertion sequence IS6110.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS6110-16
AL123456.3	EMBL	repeat_region	3890779	3890806	.	+	.	ID=id-AL123456.3:3890779..3890806;Note=28 bp inverted repeat at left end of IS6110 :TGAACCGCCCCGGCATGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	3890830	3891156	.	+	.	ID=gene-Rv3474;Name=Rv3474;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3474
AL123456.3	EMBL	CDS	3890830	3891156	.	+	0	ID=cds-CCP46296.1;Parent=gene-Rv3474;Dbxref=EnsemblGenomes-Gn:Rv3474,EnsemblGenomes-Tr:CCP46296,GOA:P9WKH5,InterPro:IPR002514,InterPro:IPR009057,NCBI_GP:CCP46296.1;Name=CCP46296.1;Note=Rv3474%2C (MTCY13E12.27)%2C len: 108 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3474 and Rv3475%2C the sequence UUUUAAAG (directly upstream of Rv3475) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Belongs to the transposase family 8.;gbkey=CDS;locus_tag=Rv3474;product=Possible transposase for insertion element IS6110 (fragment);protein_id=CCP46296.1;transl_table=11
AL123456.3	EMBL	gene	3891105	3892091	.	+	.	ID=gene-Rv3475;Name=Rv3475;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3475;partial=true;start_range=.,3891105
AL123456.3	EMBL	CDS	3891105	3892091	.	+	0	ID=cds-CCP46297.1;Parent=gene-Rv3475;Dbxref=EnsemblGenomes-Gn:Rv3475,EnsemblGenomes-Tr:CCP46297,GOA:P9WKH9,InterPro:IPR001584,InterPro:IPR012337,InterPro:IPR025948,NCBI_GP:CCP46297.1;Name=CCP46297.1;Note=Rv3475%2C (MTCY13E12.28)%2C len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3474 and Rv3475%2C the sequence UUUUAAAG (directly upstream of Rv3475) maybe responsible for such a frameshifting event (see McAdam et al.%2C 1990). Start changed since first submission (- 18 aa).;gbkey=CDS;locus_tag=Rv3475;partial=true;product=Possible transposase for insertion element IS6110 [second part];protein_id=CCP46297.1;start_range=.,3891105;transl_table=11
AL123456.3	EMBL	repeat_region	3892106	3892133	.	-	.	ID=id-AL123456.3:3892106..3892133;Note=28 bp inverted repeat at right end of IS6110 :TGAACCGCCCCGGTGAGTCCGGAGACTC;gbkey=repeat_region
AL123456.3	EMBL	gene	3892371	3893720	.	-	.	ID=gene-Rv3476c;Name=kgtP;gbkey=Gene;gene=kgtP;gene_biotype=protein_coding;locus_tag=Rv3476c
AL123456.3	EMBL	CDS	3892371	3893720	.	-	0	ID=cds-CCP46298.1;Parent=gene-Rv3476c;Dbxref=EnsemblGenomes-Gn:Rv3476c,EnsemblGenomes-Tr:CCP46298,GOA:I6XHB8,InterPro:IPR005828,InterPro:IPR005829,InterPro:IPR016196,InterPro:IPR020846,UniProtKB/TrEMBL:I6XHB8,NCBI_GP:CCP46298.1;Name=CCP46298.1;Note=Rv3476c%2C (MTCY13E12.29c)%2C len: 449 aa. Probable kgtP%2C dicarboxylate-transport integral membrane protein%2Cpossibly member of major facilitator superfamily (MFS)%2Chighly similar to others e.g. Q9HT43|PA5530 from Pseudomonas aeruginosa (435 aa)%2C FASTA scores: opt: 1209%2CE(): 2.3e-68%2C (47.05%25 identity in 425 aa overlap)%3B Q9I6Q9|PCAT|PA0229 from Pseudomonas aeruginosa (432 aa)%2CFASTA scores: opt: 1131%2C E(): 1.8e-63%2C (40.4%25 identity in 438 aa overlap)%3B Q9WWZ2 from Pseudomonas putida (429 aa)%2CFASTA scores: opt: 1090%2C E(): 6.5e-61%2C (41.2%25 identity in 425 aa overlap)%3B P17448|KGTP_ECOLI|WITA|B2587 from Escherichia coli strain K12 (432 aa)%2C FASTA scores: opt: 1083%2C E(): 1.8e-60%2C (40.05%25 identity in 422 aa overlap)%3B etc. Also similar to O05301|MTCI364.12|Rv1200 hypothetical 44.6 KDA protein from Mycobacterium tuberculosis (425 aa)%2CFASTA scores: E(): 5.2e-25%2C (28.5%25 identity in 382 aa overlap). Contains sugar transport protein signatures 1 and 2 (PS00216%2C PS00217). Belongs to the sugar transporter family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kgtP;inference=protein motif:PROSITE:PS00217;locus_tag=Rv3476c;product=Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter);protein_id=CCP46298.1;transl_table=11
AL123456.3	EMBL	gene	3894093	3894389	.	+	.	ID=gene-Rv3477;Name=PE31;gbkey=Gene;gene=PE31;gene_biotype=protein_coding;locus_tag=Rv3477
AL123456.3	EMBL	CDS	3894093	3894389	.	+	0	ID=cds-CCP46299.1;Parent=gene-Rv3477;Dbxref=EnsemblGenomes-Gn:Rv3477,EnsemblGenomes-Tr:CCP46299,InterPro:IPR000084,UniProtKB/TrEMBL:I6YG87,NCBI_GP:CCP46299.1;Name=CCP46299.1;Note=Rv3477%2C (MTCY13E12.30)%2C len: 98 aa. PE31%2C Member of the Mycobacterium tuberculosis PE family (see Brennan %26 Delogu 2002)%2C similar to O53941|Rv1791|MTV049.13 (99 aa)%2CFASTA scores: opt: 373%2C E(): 4.3e-18%2C (64.65%25 identity in 99 aa overlap)%3B MTCI364.07%3B MTCY21C12.10c%3B MTCY1A11.25c%3B MTC1A11.04%3B MTCY359.33%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE31;locus_tag=Rv3477;product=PE family protein PE31;protein_id=CCP46299.1;transl_table=11
AL123456.3	EMBL	gene	3894426	3895607	.	+	.	ID=gene-Rv3478;Name=PPE60;gbkey=Gene;gene=PPE60;gene_biotype=protein_coding;gene_synonym=mtb39c;locus_tag=Rv3478
AL123456.3	EMBL	CDS	3894426	3895607	.	+	0	ID=cds-CCP46300.1;Parent=gene-Rv3478;Dbxref=EnsemblGenomes-Gn:Rv3478,EnsemblGenomes-Tr:CCP46300,InterPro:IPR000030,InterPro:IPR022171,UniProtKB/TrEMBL:Q6MWX1,NCBI_GP:CCP46300.1;Name=CCP46300.1;Note=Rv3478%2C (MTCY13E12.31)%2C len: 393 aa. PPE60 (alternate gene name: mtb39c). Member of the M. tuberculosis PPE family%2C highly similar to others e.g. Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa)%2CFASTA scores: opt: 2165%2C E(): 1.1e-109%2C (85.35%25 identity in 396 aa overlap)%3B MTCI364.08%3B MTCY10G2.10%3B MTCY03A2.22c%3B MTCY274.23c%3B MTCY164.34c%3B MTCY98.0029c%3B etc. Note that expression of Rv3478 was demonstrated in lysates by immunodetection (see Dillon et al.%2C 1999).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE60;locus_tag=Rv3478;product=PE family protein PPE60;protein_id=CCP46300.1;transl_table=11
AL123456.3	EMBL	gene	3895820	3898885	.	+	.	ID=gene-Rv3479;Name=Rv3479;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3479
AL123456.3	EMBL	CDS	3895820	3898885	.	+	0	ID=cds-CCP46301.1;Parent=gene-Rv3479;Dbxref=EnsemblGenomes-Gn:Rv3479,EnsemblGenomes-Tr:CCP46301,GOA:O06342,InterPro:IPR002641,InterPro:IPR016035,InterPro:IPR019894,InterPro:IPR024282,UniProtKB/TrEMBL:O06342,NCBI_GP:CCP46301.1;Name=CCP46301.1;Note=Rv3479%2C (MTCY13E12.32)%2C len: 1021 aa. Possible transmembrane protein%2C with hydrophobic stretches at C-terminus. Start changed since first submission (-54 aa). Alternative nucleotide at position 3896340 (T->G%3B L174R) has been observed.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3479;product=Possible transmembrane protein;protein_id=CCP46301.1;transl_table=11
AL123456.3	EMBL	gene	3898909	3900402	.	-	.	ID=gene-Rv3480c;Name=Rv3480c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3480c
AL123456.3	EMBL	CDS	3898909	3900402	.	-	0	ID=cds-CCP46302.1;Parent=gene-Rv3480c;Dbxref=EnsemblGenomes-Gn:Rv3480c,EnsemblGenomes-Tr:CCP46302,GOA:P9WKA7,InterPro:IPR004255,InterPro:IPR009721,InterPro:IPR014292,NCBI_GP:CCP46302.1;Name=CCP46302.1;Note=Rv3480c%2C (MTCY13E12.33c)%2C len: 497 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa)%2C FASTA scores: opt: 520%2C E(): 2e-23%2C (39.95%25 identity in 488 aa overlap)%3B Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505 aa)%2C FASTA scores: opt: 434%2C E(): 2.7e-18%2C (34.2%25 identity in 497 aa overlap)%3B AAK45165|MT0919 (520 aa)%2C FASTA scores: opt: 434%2C E(): 2.7e-18%2C (34.2%25 identity in 497 aa overlap)%3B etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from Mycobacterium leprae (491 aa)%2C FASTA scores: opt: 272%2C E(): 1e-08%2C (28.85%25 identity in 485 aa overlap)%3B and Q9RIU8|CM11.13c hypothetical 47.1 KDA protein from Streptomyces coelicolor (446 aa)%2C FASTA scores: opt: 254%2CE(): 1.1e-07%2C (30.4%25 identity in 497 aa overlap). Seems to belong to the UPF0089 family.;gbkey=CDS;locus_tag=Rv3480c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP46302.1;transl_table=11
AL123456.3	EMBL	gene	3900493	3901182	.	-	.	ID=gene-Rv3481c;Name=Rv3481c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3481c
AL123456.3	EMBL	CDS	3900493	3901182	.	-	0	ID=cds-CCP46303.1;Parent=gene-Rv3481c;Dbxref=EnsemblGenomes-Gn:Rv3481c,EnsemblGenomes-Tr:CCP46303,InterPro:IPR021315,UniProtKB/TrEMBL:I6XHC3,NCBI_GP:CCP46303.1;Name=CCP46303.1;Note=Rv3481c%2C (MTCY13E12.34c)%2C len: 229 aa. Probable integral membrane protein. No real similarity with others.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3481c;product=Probable integral membrane protein;protein_id=CCP46303.1;transl_table=11
AL123456.3	EMBL	gene	3901324	3902106	.	-	.	ID=gene-Rv3482c;Name=Rv3482c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3482c
AL123456.3	EMBL	CDS	3901324	3902106	.	-	0	ID=cds-CCP46304.1;Parent=gene-Rv3482c;Dbxref=EnsemblGenomes-Gn:Rv3482c,EnsemblGenomes-Tr:CCP46304,InterPro:IPR018929,UniProtKB/TrEMBL:I6YG92,NCBI_GP:CCP46304.1;Name=CCP46304.1;Note=Rv3482c%2C (MTCY13E12.35c)%2C len: 260 aa. Probable conserved membrane protein. N-terminal region shares some similarity with N-terminus of O88067|SCI35.32c putative membrane protein from Streptomyces coelicolor (319 aa)%2CFASTA scores: opt: 155%2C E(): 0.023%2C (54.55%25 identity in 33 aa overlap)%3B and with C-terminus of O06254|Rv3437|MTCY77.09 hypothetical 17.9 KDA protein from Mycobacterium tuberculosis strain H37Rv (alias AAK47883|MT3542.1 from strain CDC1551) (158 aa)%2C FASTA scores: opt: 140%2C E(): 0.11%2C (58.8%25 identity in 34 aa overlap). Some similarity to others e.g. Q9XAN5|SC4C6.05c putative membrane protein from Streptomyces coelicolor (347 aa)%2C FASTA scores: opt: 131%2CE(): 0.75%2C (29.4%25 identity in 221 aa overlap). First start taken.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3482c;product=Probable conserved membrane protein;protein_id=CCP46304.1;transl_table=11
AL123456.3	EMBL	gene	3902150	3902812	.	-	.	ID=gene-Rv3483c;Name=Rv3483c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3483c
AL123456.3	EMBL	CDS	3902150	3902812	.	-	0	ID=cds-CCP46305.1;Parent=gene-Rv3483c;Dbxref=EnsemblGenomes-Gn:Rv3483c,EnsemblGenomes-Tr:CCP46305,InterPro:IPR025971,UniProtKB/TrEMBL:I6X7F2,NCBI_GP:CCP46305.1;Name=CCP46305.1;Note=Rv3483c%2C (MTCY13E12.36c)%2C len: 220 aa. Possible exported protein%2C similar to Q9CC94|ML1099 putative lipoprotein from Mycobacterium leprae (202 aa)%2C FASTA scores: opt: 276%2C E(): 1.4e-08%2C (33.1%25 identity in 148 aa overlap). Also showing similarity with Mycobacterium tuberculosis proteins Q11065|LPRE_MYCTU|LPRE|Rv1252c|MT1291|MTCY50.30. putative lipoprotein precursor (202 aa)%2C FASTA scores: opt: 276%2CE(): 1.4e-08%2C (29.5%25 identity in 200 aa overlap)%3B O53445|Rv1097c|MTV017.50c hypothetical 29.9 KDA protein (293 aa)%2C FASTA scores: opt: 161%2C E(): 0.047%2C (25.4%25 identity in 118 aa overlap)%3B P71882|LPPP_MYCTU|Rv2330c|MT2392|MTCY3G12.04 putative lipoprotein precursor (175 aa)%2C FASTA scores: opt: 146%2CE(): 0.21%2C (28.25%25 identity in 184 aa overlap)%3B and O06170|Rv2507|MTCY07A7.13 hypothetical 28.5 KDA protein (273 aa)%2C FASTA scores: opt: 148%2C E(): 0.23%2C (25.15%25 identity in 191 aa overlap). Contains possible N-terminal signal sequence;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3483c;product=Possible exported protein;protein_id=CCP46305.1;transl_table=11
AL123456.3	EMBL	gene	3903078	3904616	.	+	.	ID=gene-Rv3484;Name=cpsA;gbkey=Gene;gene=cpsA;gene_biotype=protein_coding;locus_tag=Rv3484
AL123456.3	EMBL	CDS	3903078	3904616	.	+	0	ID=cds-CCP46306.1;Parent=gene-Rv3484;Dbxref=EnsemblGenomes-Gn:Rv3484,EnsemblGenomes-Tr:CCP46306,GOA:O06347,InterPro:IPR004474,InterPro:IPR027381,UniProtKB/TrEMBL:O06347,NCBI_GP:CCP46306.1;Name=CCP46306.1;Note=Rv3484%2C (MTCY13E12.37)%2C len: 512 aa. Possible cpsA%2Chypothetical protein%2C equivalent to Q50160|CPSA|ML2247 hypothetical protein CPSA from Mycobacterium leprae (516 aa)%2C FASTA scores: opt: 2557%2C E(): 1.6e-143%2C (74.9%25 identity in 518 aa overlap)%3B and with good similarity to Q9CCK9|ML0750 hypothetical protein from Mycobacterium leprae (489 aa)%2C FASTA scores: opt: 855%2C E(): 4.6e-43%2C(34.45%25 identity in 502 aa overlap). Also similar (or with similarity) to hypothetical proteins from Mycobacterium tuberculosis: P96872|Rv3267|MTCY71.07 (498 aa)%2C FASTA scores: opt: 928%2C E(): 2.3e-47%2C (37.35%25 identity in 498 aa overlap)%3B and O53834|Rv0822c|MTV043.14c (684 aa)%2C FASTA scores: opt: 425%2C E(): 1.5e-17%2C (26.15%25 identity in 524 aa overlap). Shows also similarity with various bacterial proteins e.g. Q9KZK0|SCE34.26 conserved hypothetical protein from Streptomyces coelicolor (507 aa)%2C FASTA scores: opt: 329%2C E(): 5.3e-12%2C (28.85%25 identity in 478 aa overlap)%3B Q9K4E6|2SC6G5.02 conserved hypothetical protein%2Cpossible membrane protein%2C from Streptomyces coelicolor (382 aa)%2C FASTA scores: opt: 305%2C E(): 1.1e-10%2C (29.8%25 identity in 386 aa overlap)%3B O69850|SC1C3.08c putative transcriptional regulator from Streptomyces coelicolor (366 aa)%2C FASTA scores: opt: 304%2C E(): 1.2e-10%2C (29.6%25 identity in 395 aa overlap)%3B Q9KZK3|SCE34.23 putative transcriptional regulator from Streptomyces coelicolor (396 aa)%2C FASTA scores: opt: 296%2C E(): 3.8e-10%2C (31.25%25 identity in 349 aa overlap)%3B AAK43602|CPSA CPSA protein from Streptococcus agalactiae (485 aa)%2C FASTA scores: opt: 250%2CE(): 2.4e-07%2C (30.25%25 identity in 162 aa overlap)%3B etc. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cpsA;locus_tag=Rv3484;product=Possible conserved protein CpsA;protein_id=CCP46306.1;transl_table=11
AL123456.3	EMBL	gene	3904622	3905566	.	-	.	ID=gene-Rv3485c;Name=Rv3485c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3485c
AL123456.3	EMBL	CDS	3904622	3905566	.	-	0	ID=cds-CCP46307.1;Parent=gene-Rv3485c;Dbxref=EnsemblGenomes-Gn:Rv3485c,EnsemblGenomes-Tr:CCP46307,GOA:O06348,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:O06348,NCBI_GP:CCP46307.1;Name=CCP46307.1;Note=Rv3485c%2C (MTCY13E12.38c)%2C len: 314 aa. Probable short-chain dehydrogenase/reductase%2C similar%2C but longer 41 aa%2C to P71824|Rv0769|MTCY369.14 putative short-chain type dehydrogenase/reductase CY369.14 from Mycobacterium tuberculosis (248 aa)%2C FASTA scores: opt: 462%2C E(): 1.8e-19%2C (34.0%25 identity in 253 aa overlap). Also similar to various dehydrogenases e.g. P25529|HDHA_ECOLI|HSDH|B1619 NAD-dependent 7 alpha-hydroxysteroid dehydrogenase (SDR family) from Escherichia coli strain K12 (alias BAB35750|ECS2327 or AAG56608|HDHA for strain O157:H7) (255 aa)%2C FASTA scores: opt: 462%2C E(): 1.8e-19%2C (34.7%25 identity in 248 aa overlap)%3B Q9FD15|RUBG putative reductase (SDR family) from Streptomyces collinus (249 aa)%2C FASTA scores: opt: 446%2C E(): 1.5e-18%2C (36.1%25 identity in 255 aa overlap)%3B BAB51974|MLL5540 putative dehydrogenase from Rhizobium loti (Mesorhizobium loti) (253 aa)%2C FASTA scores: opt: 442%2C E(): 2.5e-18%2C (36.25%25 identity in 251 aa overlap)%3B Q08632|SDR1_PICAB short-chain type dehydrogenase/reductase (SDR family) from Picea abies (Norway spruce) (Picea excelsa) (271 aa)%2C FASTA scores: opt: 441%2C E(): 3.1e-18%2C(32.3%25 identity in 260 aa overlap)%3B Q9A326|CC3380 2-deoxy-D-gluconate 3-dehydrogenase from Caulobacter crescentus (260 aa)%2C FASTA scores: opt: 436%2C E(): 5.7e-18%2C(32.8%25 identity in 253 aa overlap)%3B Q16698|DECR_HUMAN 2%2C4-dienoyl-CoA reductase%2C mitochondrial precursor from Homo sapiens (Human) (335 aa)%2C FASTA scores: opt: 430%2C E(): 1.5e-17%2C (30.4%25 identity in 306 aa overlap)%3B etc. Contains short-chain alcohol dehydrogenase family signature (PS00061). Belongs to the short-chain dehydrogenases/reductases family (SDR).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv3485c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP46307.1;transl_table=11
AL123456.3	EMBL	gene	3905772	3906221	.	+	.	ID=gene-Rv3486;Name=Rv3486;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3486
AL123456.3	EMBL	CDS	3905772	3906221	.	+	0	ID=cds-CCP46308.1;Parent=gene-Rv3486;Dbxref=EnsemblGenomes-Gn:Rv3486,EnsemblGenomes-Tr:CCP46308,InterPro:IPR011637,UniProtKB/TrEMBL:O06349,NCBI_GP:CCP46308.1;Name=CCP46308.1;Note=Rv3486%2C (MTCY13E12.39)%2C len: 149 aa. Conserved protein%2C similar to Q9RC47|YFID|BH3304 hypothetical protein from Bacillus halodurans (129 aa)%2C FASTA scores: opt: 186%2CE(): 2.1e-05%2C (40.0%25 identity in 95 aa overlap)%3B and Q9KKT1|VCA1019 hypothetical protein from Vibrio cholerae (148 aa)%2C FASTA scores: opt: 128%2C E(): 0.15%2C (35.25%25 identity in 139 aa overlap). Some similarity to other proteins e.g. P54720|YFID_BACSU hypothetical protein from Bacillus subtilis (134 aa)%2C FASTA scores: opt: 165%2C E(): 0.00052%2C (31.75%25 identity in 126 aa overlap). Equivalent to AAK47949 from Mycobacterium tuberculosis strain CDC1551 (163 aa) but shorter 14 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3486;product=Conserved protein;protein_id=CCP46308.1;transl_table=11
AL123456.3	EMBL	gene	3906174	3907007	.	-	.	ID=gene-Rv3487c;Name=lipF;gbkey=Gene;gene=lipF;gene_biotype=protein_coding;locus_tag=Rv3487c
AL123456.3	EMBL	CDS	3906174	3907007	.	-	0	ID=cds-CCP46309.1;Parent=gene-Rv3487c;Dbxref=EnsemblGenomes-Gn:Rv3487c,EnsemblGenomes-Tr:CCP46309,GOA:O06350,InterPro:IPR002168,InterPro:IPR013094,InterPro:IPR029058,NCBI_GP:CCP46309.1;Name=CCP46309.1;Note=Rv3487c%2C (MTCY13E12.41c)%2C len: 277 aa. Probable lipF%2C esterase/lipase (see citation below)%2C highly similar%2Cbut shorter 50 aa%2C to O53424|LIPU|Rv1076|MTV017.29 putative esterase/lipase from Mycobacterium tuberculosis (297 aa)%2CFASTA scores: opt: 1229%2C E(): 3.3e-71%2C (76.4%25 identity in 246 aa overlap)%3B and similar to other putative lipases from Mycobacterium tuberculosis e.g. P71759|LIPK|RV2385|MTCY253.36c (306 aa)%2C FASTA scores: opt: 468%2C E(): 1.2e-22%2C (36.2%25 identity in 254 aa overlap). Equivalent%2C but shorter 79 aa%2C to Q9ZBM4|MLCB1450.08|ML0314 putative hydrolase (putative esterase) from Mycobacterium leprae (335 aa)%2C FASTA scores: opt: 1225%2C E(): 6.6e-71%2C(73.6%25 identity in 250 aa overlap). Also similar to esterases and lipases of around 300 aa e.g. Q44087|est esterase precursor from Acinetobacter lwoffii (303 aa)%2CFASTA scores: opt: 428%2C E(): 4.3e-20%2C (31.85%25 identity in 251 aa overlap)%3B P18773|EST_ACICA esterase from Acinetobacter calcoaceticus (303 aa)%2C FASTA scores: opt: 420%2C E(): 1.4e-19%2C (31.5%25 identity in 251 aa overlap)%3B Q9KIU1 esterase from uncultured bacterium Plasmid pAH116 (308 aa)%2C FASTA scores: opt: 405%2C E(): 1.3e-18%2C (35.1%25 identity in 242 aa overlap)%3B Q9X8J4|SCE9.22 putative esterase from Streptomyces coelicolor (266 aa)%2C FASTA scores: opt: 390%2C E(): 1e-17%2C (35.85%25 identity in 237 aa overlap)%3B etc. Equivalent to AAK47950 from Mycobacterium tuberculosis strain CDC1551 (327 aa) but shorter 50 aa.;gbkey=CDS;gene=lipF;locus_tag=Rv3487c;product=Probable esterase/lipase LipF;protein_id=CCP46309.1;transl_table=11
AL123456.3	EMBL	gene	3907667	3907990	.	+	.	ID=gene-Rv3488;Name=Rv3488;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3488
AL123456.3	EMBL	CDS	3907667	3907990	.	+	0	ID=cds-CCP46310.1;Parent=gene-Rv3488;Dbxref=EnsemblGenomes-Gn:Rv3488,EnsemblGenomes-Tr:CCP46310,InterPro:IPR005149,InterPro:IPR011991,UniProtKB/TrEMBL:I6X7F9,NCBI_GP:CCP46310.1;Name=CCP46310.1;Note=Rv3488%2C (MTCY13E12.41)%2C len: 107 aa. Hypothetical protein%2C similar to various bacterial proteins e.g. O28730|AF1542 conserved hypothetical protein from Archaeoglobus fulgidus (101 aa)%2C FASTA scores: opt: 321%2CE(): 6.4e-15%2C (50.55%25 identity in 87 aa overlap)%3B O50207 SQ1_IV (fragment) from Rhodococcus erythropolis (59 aa)%2CFASTA scores: opt: 298%2C E(): 1.4e-13%2C (71.2%25 identity in 59 aa overlap)%3B Q9KFB0|BH0575 BH0575 protein from Bacillus halodurans (102 aa)%2C FASTA scores: opt: 294%2C E(): 4.1e-13%2C(43.15%25 identity in 95 aa overlap)%3B etc. Also similar to Mycobacterium tuberculosis P71704|Rv0047c|MTCY21D4.10c (180 aa) (37.8%25 identity in 82 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3488;product=Conserved hypothetical protein;protein_id=CCP46310.1;transl_table=11
AL123456.3	EMBL	gene	3908072	3908236	.	+	.	ID=gene-Rv3489;Name=Rv3489;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3489
AL123456.3	EMBL	CDS	3908072	3908236	.	+	0	ID=cds-CCP46311.1;Parent=gene-Rv3489;Dbxref=EnsemblGenomes-Gn:Rv3489,EnsemblGenomes-Tr:CCP46311,UniProtKB/TrEMBL:I6YC91,NCBI_GP:CCP46311.1;Name=CCP46311.1;Note=Rv3489%2C (MTCY13E12.42)%2C len: 54 aa. Unknown protein. No similarity with other proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3489;product=Unknown protein;protein_id=CCP46311.1;transl_table=11
AL123456.3	EMBL	gene	3908236	3909738	.	+	.	ID=gene-Rv3490;Name=otsA;gbkey=Gene;gene=otsA;gene_biotype=protein_coding;locus_tag=Rv3490
AL123456.3	EMBL	CDS	3908236	3909738	.	+	0	ID=cds-CCP46312.1;Parent=gene-Rv3490;Dbxref=EnsemblGenomes-Gn:Rv3490,EnsemblGenomes-Tr:CCP46312,GOA:P9WN11,InterPro:IPR001830,NCBI_GP:CCP46312.1;Name=CCP46312.1;Note=Rv3490%2C (MTCY13E12.43)%2C len: 500 aa. otsA%2C alpha%2Calpha-trehalose-phosphate synthase (see citations below)%2Cequivalent to Q50167|OTSA|ML2254 probable trehalose-phosphate synthase from Mycobacterium leprae (498 aa)%2C FASTA scores: opt: 2706%2C E(): 1.6e-166%2C (80.3%25 identity in 497 aa overlap). Also similar to others e.g. Q92410|TPS1_CANAL from Candida albicans (Yeast) (478 aa)%2CFASTA scores: opt: 895%2C E(): 4.9e-50%2C (37.15%25 identity in 479 aa overlap)%3B Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YBR 0922 from Saccharomyces cerevisiae (Baker's yeast) (495 aa)%2CFASTA scores: opt: 847%2C E(): 6.2e-47%2C (36.1%25 identity in 490 aa overlap)%3B BAB48232|MLL0691 from Rhizobium loti (Mesorhizobium loti) (520 aa)%2C FASTA scores: opt: 884%2C E(): 2.7e-49%2C (36.2%25 identity in 478 aa overlap)%3B etc. Equivalent to AAK47953 from Mycobacterium tuberculosis strain CDC1551 (478 aa) but longer 22 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=otsA;locus_tag=Rv3490;product=Alpha%2C alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-UDP glucosyl transferase);protein_id=CCP46312.1;transl_table=11
AL123456.3	EMBL	gene	3909890	3910468	.	+	.	ID=gene-Rv3491;Name=Rv3491;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3491
AL123456.3	EMBL	CDS	3909890	3910468	.	+	0	ID=cds-CCP46313.1;Parent=gene-Rv3491;Dbxref=EnsemblGenomes-Gn:Rv3491,EnsemblGenomes-Tr:CCP46313,UniProtKB/TrEMBL:I6XHD1,NCBI_GP:CCP46313.1;Name=CCP46313.1;Note=Rv3491%2C (MTCY13E12.44)%2C len: 192 aa. Unknown protein. No significant homology with other proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3491;product=Unknown protein;protein_id=CCP46313.1;transl_table=11
AL123456.3	EMBL	gene	3910465	3910947	.	-	.	ID=gene-Rv3492c;Name=Rv3492c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3492c
AL123456.3	EMBL	CDS	3910465	3910947	.	-	0	ID=cds-CCP46314.1;Parent=gene-Rv3492c;Dbxref=EnsemblGenomes-Gn:Rv3492c,EnsemblGenomes-Tr:CCP46314,InterPro:IPR021055,UniProtKB/TrEMBL:I6YGA5,NCBI_GP:CCP46314.1;Name=CCP46314.1;Note=Rv3492c%2C (MTCY13E12.45c)%2C len: 160 aa. Conserved hypothetical Mce-associated protein%2C showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3) (160 aa)%2C FASTA scores: opt: 214%2C E(): 2.6e-07%2C (25.3%25 identity in 154 aa overlap)%3B and Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220 aa)%2CFASTA scores: opt: 187%2C E(): 2e-05%2C (23.4%25 identity in 154 aa overlap). Contains lipocalin signature at C-terminus (PS00213). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00213;locus_tag=Rv3492c;product=Conserved hypothetical Mce associated protein;protein_id=CCP46314.1;transl_table=11
AL123456.3	EMBL	gene	3910947	3911675	.	-	.	ID=gene-Rv3493c;Name=Rv3493c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3493c
AL123456.3	EMBL	CDS	3910947	3911675	.	-	0	ID=cds-CCP46315.1;Parent=gene-Rv3493c;Dbxref=EnsemblGenomes-Gn:Rv3493c,EnsemblGenomes-Tr:CCP46315,UniProtKB/TrEMBL:I6X7G4,NCBI_GP:CCP46315.1;Name=CCP46315.1;Note=Rv3493c%2C (MTCY13E12.46c)%2C len: 242 aa. Conserved hypothetical Mce-associated ala-%2C val-rich protein%2C showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near Mce operon1) from Mycobacterium tuberculosis (244 aa)%2C FASTA scores: opt: 163%2C E(): 0.046%2C (24.65%25 identity in 211 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3493c;product=Conserved hypothetical Mce associated alanine and valine rich protein;protein_id=CCP46315.1;transl_table=11
AL123456.3	EMBL	gene	3911675	3913369	.	-	.	ID=gene-Rv3494c;Name=mce4F;gbkey=Gene;gene=mce4F;gene_biotype=protein_coding;locus_tag=Rv3494c
AL123456.3	EMBL	CDS	3911675	3913369	.	-	0	ID=cds-CCP46316.1;Parent=gene-Rv3494c;Dbxref=EnsemblGenomes-Gn:Rv3494c,EnsemblGenomes-Tr:CCP46316,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:I6YC95,NCBI_GP:CCP46316.1;Name=CCP46316.1;Note=Rv3494c%2C (MTV023.01c)%2C len: 564 aa. Mce4F%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C similar to Mycobacterium tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515 aa)%3B O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa)%3B and O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to others e.g. Q9CD09|MCE1F|ML2594 putative secreted protein from Mycobacterium leprae (516 aa)%2C FASTA scores: opt: 1040%2C E(): 3.6e-31%2C (35.9%25 identity in 529 aa overlap)%3B Q9F361|SC8A2.02c putative secreted protein from Streptomyces coelicolor (433 aa)%2C FASTA scores: opt: 570%2CE(): 3.7e-14%2C (30.8%25 identity in 458 aa overlap)%3B etc. Has hydrophobic stretch%2C possibly a signal peptide at the N-terminus. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce4F;locus_tag=Rv3494c;product=Mce-family protein Mce4F;protein_id=CCP46316.1;transl_table=11
AL123456.3	EMBL	gene	3913380	3914534	.	-	.	ID=gene-Rv3495c;Name=lprN;gbkey=Gene;gene=lprN;gene_biotype=protein_coding;gene_synonym=mce4E;locus_tag=Rv3495c
AL123456.3	EMBL	CDS	3913380	3914534	.	-	0	ID=cds-CCP46317.1;Parent=gene-Rv3495c;Dbxref=EnsemblGenomes-Gn:Rv3495c,EnsemblGenomes-Tr:CCP46317,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:I6Y3P1,NCBI_GP:CCP46317.1;Name=CCP46317.1;Note=Rv3495c%2C (MTV023.02c)%2C len: 384 aa. Possible lprN (alternate gene name: mce4E)%2C lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E (390 aa)%3B O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa)%3B and O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also similar to others e.g. Q9F360|SC8A2.03c putative secreted protein from Streptomyces coelicolor (413 aa)%2C FASTA scores: opt: 656%2C E(): 2.2e-32%2C (37.55%25 identity in 317 aa overlap)%3B Q9CD10|LPRK|ML2593 putative lipoprotein from Mycobacterium leprae (392 aa)%2C FASTA scores: opt: 616%2C E(): 5.5e-30%2C (28.95%25 identity in 373 aa overlap)%3B etc. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lprN;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3495c;product=Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E);protein_id=CCP46317.1;transl_table=11
AL123456.3	EMBL	gene	3914531	3915886	.	-	.	ID=gene-Rv3496c;Name=mce4D;gbkey=Gene;gene=mce4D;gene_biotype=protein_coding;locus_tag=Rv3496c
AL123456.3	EMBL	CDS	3914531	3915886	.	-	0	ID=cds-CCP46318.1;Parent=gene-Rv3496c;Dbxref=EnsemblGenomes-Gn:Rv3496c,EnsemblGenomes-Tr:CCP46318,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR024516,UniProtKB/TrEMBL:I6XHD6,NCBI_GP:CCP46318.1;Name=CCP46318.1;Note=Rv3496c%2C (MTV023.03c)%2C len: 451 aa. Mce4D%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa)%3B O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa)%3B and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 putative secreted protein from Mycobacterium leprae (531 aa)%2C FASTA scores: opt: 837%2CE(): 2.6e-34%2C (34.55%25 identity in 446 aa overlap)%3B Q9F359|SC8A2.04c putative secreted protein from Streptomyces coelicolor (337 aa)%2C FASTA scores: opt: 606%2CE(): 4.9e-23%2C (32.35%25 identity in 300 aa overlap)%3B etc. Hydrophobic region at N-terminus. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=mce4D;locus_tag=Rv3496c;product=Mce-family protein Mce4D;protein_id=CCP46318.1;transl_table=11
AL123456.3	EMBL	gene	3915883	3916956	.	-	.	ID=gene-Rv3497c;Name=mce4C;gbkey=Gene;gene=mce4C;gene_biotype=protein_coding;locus_tag=Rv3497c
AL123456.3	EMBL	CDS	3915883	3916956	.	-	0	ID=cds-CCP46319.1;Parent=gene-Rv3497c;Dbxref=EnsemblGenomes-Gn:Rv3497c,EnsemblGenomes-Tr:CCP46319,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR008360,UniProtKB/TrEMBL:I6YGB1,NCBI_GP:CCP46319.1;Name=CCP46319.1;Note=Rv3497c%2C (MTV023.04c)%2C len: 357 aa. Mce4C%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa)%3B O07787|Rv0591|MTCY19H5.31|mce2C (481 aa)%3B and O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to others e.g. Q9F358|SC8A2.05c putative secreted protein from Streptomyces coelicolor (351 aa)%2C FASTA scores: opt: 658%2CE(): 1.1e-30%2C (33.95%25 identity in 318 aa overlap)%3B Q9CD12|MCE1C|ML2591 putative secreted protein from Mycobacterium leprae (519 aa)%2C FASTA scores: opt: 555%2C E(): 1.2e-24%2C (28.35%25 identity in 328 aa overlap)%3B etc. Hydrophobic region at N-terminus. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce4C;locus_tag=Rv3497c;product=Mce-family protein Mce4C;protein_id=CCP46319.1;transl_table=11
AL123456.3	EMBL	gene	3916946	3917998	.	-	.	ID=gene-Rv3498c;Name=mce4B;gbkey=Gene;gene=mce4B;gene_biotype=protein_coding;locus_tag=Rv3498c
AL123456.3	EMBL	CDS	3916946	3917998	.	-	0	ID=cds-CCP46320.1;Parent=gene-Rv3498c;Dbxref=EnsemblGenomes-Gn:Rv3498c,EnsemblGenomes-Tr:CCP46320,InterPro:IPR003399,InterPro:IPR005693,UniProtKB/TrEMBL:I6X7G8,NCBI_GP:CCP46320.1;Name=CCP46320.1;Note=Rv3498c%2C (MTV023.05c)%2C len: 350 aa. Mce4B%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346 aa)%3B O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa)%3B and O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to others e.g. Q9CD13|MCE1B|ML2590 putative secreted protein from Mycobacterium leprae (346 aa)%2C FASTA scores: opt: 803%2CE(): 6.1e-41%2C (41.05%25 identity in 346 aa overlap)%3B Q9F357|SC8A2.06c putative secreted protein from Streptomyces coelicolor (354 aa)%2C FASTA scores: opt: 624%2CE(): 3.4e-30%2C (32.55%25 identity in 338 aa overlap)%3B etc. Hydrophobic region at N-terminus. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce4B;locus_tag=Rv3498c;product=Mce-family protein Mce4B;protein_id=CCP46320.1;transl_table=11
AL123456.3	EMBL	gene	3917998	3919200	.	-	.	ID=gene-Rv3499c;Name=mce4A;gbkey=Gene;gene=mce4A;gene_biotype=protein_coding;gene_synonym=mce4;locus_tag=Rv3499c
AL123456.3	EMBL	CDS	3917998	3919200	.	-	0	ID=cds-CCP46321.1;Parent=gene-Rv3499c;Dbxref=EnsemblGenomes-Gn:Rv3499c,EnsemblGenomes-Tr:CCP46321,InterPro:IPR003399,InterPro:IPR005693,InterPro:IPR024516,UniProtKB/TrEMBL:I6YC99,NCBI_GP:CCP46321.1;Name=CCP46321.1;Note=Rv3499c%2C (MTV023.06c)%2C len: 400 aa. Mce4A%3B belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa)%3B O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa)%3B and O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar to others e.g. Q9F356|SC8A2.07c putative secreted protein from Streptomyces coelicolor (418 aa)%2C FASTA scores: opt: 619%2C E(): 7.8e-30%2C (32.4%25 identity in 352 aa overlap)%3B Q9S4U5|MCE1 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa)%2C FASTA scores: opt: 529%2CE(): 2.1e-24%2C (30.35%25 identity in 448 aa overlap)%3B Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441 aa)%2CFASTA scores: opt: 515%2C E(): 1.4e-23%2C (28.35%25 identity in 430 aa overlap)%3B etc. Contains a possible N-terminal signal sequence. Note that previously known as mce4. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mce4A;locus_tag=Rv3499c;product=Mce-family protein Mce4A;protein_id=CCP46321.1;transl_table=11
AL123456.3	EMBL	gene	3919220	3920062	.	-	.	ID=gene-Rv3500c;Name=yrbE4B;gbkey=Gene;gene=yrbE4B;gene_biotype=protein_coding;gene_synonym=supB;locus_tag=Rv3500c
AL123456.3	EMBL	CDS	3919220	3920062	.	-	0	ID=cds-CCP46322.1;Parent=gene-Rv3500c;Dbxref=EnsemblGenomes-Gn:Rv3500c,EnsemblGenomes-Tr:CCP46322,InterPro:IPR003453,UniProtKB/TrEMBL:I6Y3P5,NCBI_GP:CCP46322.1;Name=CCP46322.1;Note=Rv3500c%2C (MTV023.07c)%2C len: 280 aa. YrbE4B%2Cconserved integral membrane protein%2C part of mce4 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289 aa)%3B O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa)%3B and O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type%2C e.g. Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289 aa)%2CFASTA scores: opt: 973%2C E(): 1.5e-50%2C (50.2%25 identity in 269 aa overlap)%3B P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa)%2C FASTA scores: opt: 270%2C E(): 6e-11%2C(25.4%25 identity in 264 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yrbE4B;locus_tag=Rv3500c;product=Conserved integral membrane protein YrbE4B. Possible ABC transporter.;protein_id=CCP46322.1;transl_table=11
AL123456.3	EMBL	gene	3920097	3920861	.	-	.	ID=gene-Rv3501c;Name=yrbE4A;gbkey=Gene;gene=yrbE4A;gene_biotype=protein_coding;gene_synonym=supA;locus_tag=Rv3501c
AL123456.3	EMBL	CDS	3920097	3920861	.	-	0	ID=cds-CCP46323.1;Parent=gene-Rv3501c;Dbxref=EnsemblGenomes-Gn:Rv3501c,EnsemblGenomes-Tr:CCP46323,InterPro:IPR003453,UniProtKB/TrEMBL:O53546,NCBI_GP:CCP46323.1;Name=CCP46323.1;Note=Rv3501c%2C (MTV023.08c)%2C len: 254 aa. YrbE4A%2Cconserved integral membrane protein%2C part of mce4 operon and member of YrbE family (see citations below)%2C highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa)%3B O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa)%3B and O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly similar to conserved hypothetical integral membrane proteins of the P45030|YRBE_HAEIN (261 aa) type%2C e.g. Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267 aa)%2CFASTA scores: opt: 1059%2C E(): 1e-57%2C (64.75%25 identity in 247 aa overlap)%3B P45030|YRBE_HAEIN|HI1086 from Haemophilus influenzae (261 aa)%2C FASTA scores: opt: 313%2C E(): 3e-14%2C(25.7%25 identity in 241 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=yrbE4A;locus_tag=Rv3501c;product=Conserved integral membrane protein YrbE4A. Possible ABC transporter.;protein_id=CCP46323.1;transl_table=11
AL123456.3	EMBL	gene	3921087	3922040	.	-	.	ID=gene-Rv3502c;Name=Rv3502c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3502c
AL123456.3	EMBL	CDS	3921087	3922040	.	-	0	ID=cds-CCP46324.1;Parent=gene-Rv3502c;Dbxref=EnsemblGenomes-Gn:Rv3502c,EnsemblGenomes-Tr:CCP46324,GOA:O53547,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:O53547,NCBI_GP:CCP46324.1;Name=CCP46324.1;Note=Rv3502c%2C (MTV023.09c)%2C len: 317 aa (start uncertain). Probable short-chain dehydrogenase/reductase %2Csimilar to Mycobacterium tuberculosis proteins P71853|Rv3548c|MTCY03C7.08 hypothetical 31.1 KDA protein (304 aa)%2C FASTA scores: opt: 739%2C E(): 6.2e-35%2C (45.15%25 identity in 310 aa overlap)%3B and Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 putative oxidoreductase (247 aa)%2C FASTA scores: opt: 475%2C E(): 5.1e-20%2C (40.15%25 identity in 254 aa overlap). Also similar to various dehydrogenases e.g. Q9I4V1|PA1023 probable short-chain dehydrogenase from Pseudomonas aeruginosa (305 aa)%2C FASTA scores: opt: 535%2C E(): 2.3e-23%2C (37.1%25 identity in 302 aa overlap)%3B Q9UVH9|FOX2 FOX2 protein (SDR family) (1015 aa)%2C FASTA scores: opt: 487%2C E(): 3.2e-20%2C (38.4%25 identity in 276 aa overlap)%3B P22414|FOX2_CANTR peroxisomal hydratase-dehydrogenase%2C D-3-hydroxyacyl CoA dehydrogenase (SDR family) from Candida tropicalis (Yeast) (906 aa) FASTA scores: opt: 481%2C E(): 6.4e-20%2C (38.0%25 identity in 250 aa overlap)%3B P50171|DHB8_MOUSE|HSD17B8|HKE6|H2-KE6 estradiol 17 beta-dehydrogenase 8 from Mus musculus (Mouse) (260 aa) FASTA scores: opt: 459%2C E(): 4.3e-19%2C (39.75%25 identity in 259 aa overlap)%3B CAC41362|BKR1 3-oxyacyl-[acyl-carrier protein] reductase (fragment) from Brassica napus (Rape) (317 aa)%2C FASTA scores: opt: 447%2C E(): 2.4e-18%2C (39.2%25 identity in 255 aa overlap)%3B etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv3502c;product=Probable short-chain type dehydrogenase/reductase. Possible 17-beta-hydroxysteroid dehydrogenase.;protein_id=CCP46324.1;transl_table=11
AL123456.3	EMBL	gene	3922065	3922256	.	-	.	ID=gene-Rv3503c;Name=fdxD;gbkey=Gene;gene=fdxD;gene_biotype=protein_coding;locus_tag=Rv3503c
AL123456.3	EMBL	CDS	3922065	3922256	.	-	0	ID=cds-CCP46325.1;Parent=gene-Rv3503c;Dbxref=EnsemblGenomes-Gn:Rv3503c,EnsemblGenomes-Tr:CCP46325,GOA:I6X7H4,InterPro:IPR001080,UniProtKB/TrEMBL:I6X7H4,NCBI_GP:CCP46325.1;Name=CCP46325.1;Note=Rv3503c%2C (MTV023.10c)%2C len: 63 aa. Probable fdxD%2Cferredoxin%2C equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276%2C E(): 1.8e-13%2C (75.9%25 identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa)%2C FASTA scores: opt: 177%2C E(): 2.1e-06%2C (43.35%25 identity in 60 aa overlap)%3B Q9X4X8|DITA3 dioxygenase DITA ferredoxin component from Pseudomonas abietaniphila (78 aa)%2C FASTA scores: opt: 166%2CE(): 1.4e-05%2C (36.2%25 identity in 58 aa overlap)%3B P00203|FER_MOOTH from Moorella thermoacetica (Clostridium thermoaceticum) (63 aa)%2C FASTA scores: opt: 157%2C E(): 5.4e-05%2C (36.65%25 identity in 60 aa overlap)%3B P18325|FER2_STRGO|SUBB from Streptomyces griseolus (64 aa) FASTA scores: opt: 157%2C E(): 5.5e-05%2C (39.35%25 identity in 61 aa overlap)%3B etc. Belongs to the bacterial type ferredoxin family.;gbkey=CDS;gene=fdxD;locus_tag=Rv3503c;product=Probable ferredoxin FdxD;protein_id=CCP46325.1;transl_table=11
AL123456.3	EMBL	gene	3922471	3923673	.	+	.	ID=gene-Rv3504;Name=fadE26;gbkey=Gene;gene=fadE26;gene_biotype=protein_coding;locus_tag=Rv3504
AL123456.3	EMBL	CDS	3922471	3923673	.	+	0	ID=cds-CCP46326.1;Parent=gene-Rv3504;Dbxref=EnsemblGenomes-Gn:Rv3504,EnsemblGenomes-Tr:CCP46326,GOA:I6YCA3,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6YCA3,NCBI_GP:CCP46326.1;Name=CCP46326.1;Note=Rv3504%2C (MTV023.11)%2C len: 400 aa. Probable fadE26%2Cacyl-CoA dehydrogenase%2C similar to other acyl-CoA dehydrogenases from Mycobacterium tuberculosis e.g. P71858|FADE29|Rv3543c|MTCY03C7.13 (387 aa) FASTA scores: opt: 1031%2C E(): 7.5e-59%2C (46.25%25 identity in 402 aa overlap)%3B and P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa)%2CFASTA scores: opt: 617%2C E(): 3.1e-32%2C (32.6%25 identity in 423 aa overlap)%3B etc. Also similar to others e.g. Q9A6G3|CC2131 from Caulobacter crescentus (403 aa) FASTA scores: opt: 710%2C E(): 3.2e-38%2C (33.4%25 identity in 413 aa overlap)%3B Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa)%2C FASTA scores: opt: 522%2C E(): 3.7e-26%2C (34.1%25 identity in 358 aa overlap)%3B Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa)%2C FASTA scores: opt: 509%2C E(): 2.6e-25%2C(34.45%25 identity in 363 aa overlap)%3B etc. Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE26;locus_tag=Rv3504;product=Probable acyl-CoA dehydrogenase FadE26;protein_id=CCP46326.1;transl_table=11
AL123456.3	EMBL	gene	3923698	3924819	.	+	.	ID=gene-Rv3505;Name=fadE27;gbkey=Gene;gene=fadE27;gene_biotype=protein_coding;locus_tag=Rv3505
AL123456.3	EMBL	CDS	3923698	3924819	.	+	0	ID=cds-CCP46327.1;Parent=gene-Rv3505;Dbxref=EnsemblGenomes-Gn:Rv3505,EnsemblGenomes-Tr:CCP46327,GOA:I6Y3Q0,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6Y3Q0,NCBI_GP:CCP46327.1;Name=CCP46327.1;Note=Rv3505%2C (MTV023.12)%2C len: 373 aa. Probable fadE27%2Cacyl-CoA dehydrogenase%2C similar to other acyl-CoA dehydrogenases from Mycobacterium tuberculosis e.g. P71857|FADE28|Rv3544c|MTCY03C7.12 (339 aa) FASTA scores: opt: 497%2C E(): 1.8e-22%2C (30.3%25 identity in 343 aa overlap)%3B and P95281|FADE18|Rv1933c|MTCY09F9.31 (363 aa) FASTA scores: opt: 421%2C E(): 6.4e-18%2C (32.35%25 identity in 334 aa overlap). Also similar to other e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa)%2C FASTA scores: opt: 425%2CE(): 3.5e-18%2C (30.75%25 identity in 351 aa overlap)%3B Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa) FASTA scores: opt: 317%2C E(): 1e-11%2C (32.8%25 identity in 372 aa overlap)%3B Q9L8Q3|PDTORFO from Pseudomonas stutzeri (Pseudomonas perfectomarina) (513 aa)%2C FASTA scores: opt: 301%2C E(): 1.2e-10%2C (25.9%25 identity in 394 aa overlap)%3B etc. Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE27;locus_tag=Rv3505;product=Probable acyl-CoA dehydrogenase FadE27;protein_id=CCP46327.1;transl_table=11
AL123456.3	EMBL	gene	3924890	3926398	.	+	.	ID=gene-Rv3506;Name=fadD17;gbkey=Gene;gene=fadD17;gene_biotype=protein_coding;locus_tag=Rv3506
AL123456.3	EMBL	CDS	3924890	3926398	.	+	0	ID=cds-CCP46328.1;Parent=gene-Rv3506;Dbxref=EnsemblGenomes-Gn:Rv3506,EnsemblGenomes-Tr:CCP46328,GOA:O53551,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,NCBI_GP:CCP46328.1;Name=CCP46328.1;Note=Rv3506%2C (MTV023.13)%2C len: 502 aa. fadD17%2Cfatty-acid-CoA synthetase (ligase)%2C similar to P72007|FADD1|RV1750c|MTCY28.13c|MTCY04C12.34 from Mycobacterium tuberculosis (532 aa)%2C FASTA scores: opt: 666%2C E(): 9.8e-32%2C (52.05%25 identity in 488 aa overlap). Also similar to various ligases/synthetases e.g. Q9EY88|FCS feruloyl-CoA synthetase from Amycolatopsis sp. HR167 (491 aa)%2C FASTA scores: opt: 490%2C E(): 2.1e-21%2C (30.3%25 identity in 462 aa overlap)%3B BAB33463|ECS0040 (alias AAG54340|CAIC) probable crotonobetaine/carnitine-CoA ligase from Escherichia coli strain O157:H7 (522 aa)%2C FASTA scores: opt: 478%2C E(): 1.1e-20%2C (28.5%25 identity in 347 aa overlap)%3B Q9KHL1|ENCH putative acyl-CoA ligase from Streptomyces maritimus (535 aa)%2C FASTA scores: opt: 477%2C E(): 1.3e-20%2C(28.7%25 identity in 453 aa overlap)%3B Q50017|XCLC|ML1051 acyl-CoA synthase from Mycobacterium leprae (476 aa)%2C FASTA scores: opt: 472%2C E(): 2.3e-20%2C (31.35%25 identity in 469 aa overlap)%3B P31552|CAIC_ECOLI|B0037 from Escherichia coli strain K12 (522 aa)%2C FASTA scores: opt: 467%2C E(): 4.8e-20%2C(28.75%25 identity in 348 aa overlap)%3B Q9KBC2|BH2006 from Bacillus halodurans long-chain acyl-CoA synthetase (ligase) (513 aa)%2C FASTA scores: opt: 462%2C E(): 9.4e-20%2C (27.65%25 identity in 463 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD17;inference=protein motif:PROSITE:PS00455;locus_tag=Rv3506;product=Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase);protein_id=CCP46328.1;transl_table=11
AL123456.3	EMBL	gene	3926569	3930714	.	+	.	ID=gene-Rv3507;Name=PE_PGRS53;gbkey=Gene;gene=PE_PGRS53;gene_biotype=protein_coding;locus_tag=Rv3507
AL123456.3	EMBL	CDS	3926569	3930714	.	+	0	ID=cds-CCP46329.1;Parent=gene-Rv3507;Dbxref=EnsemblGenomes-Gn:Rv3507,EnsemblGenomes-Tr:CCP46329,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MWW9,NCBI_GP:CCP46329.1;Name=CCP46329.1;Note=Rv3507%2C (MTV023.14)%2C len: 1381 aa. PE_PGRS53%2C Member of the Mycobacterium tuberculosis PE protein family%2C PGRS subfamily of gly-rich proteins (see citation below)%2Csimilar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O06810|Rv1450c|MTCY493.04 (1329 aa)%2CFASTA scores: opt: 2173%2C E(): 1.4e-135%2C (51.15%25 identity in 1412 aa overlap). Equivalent to AAK47970 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but with some minor differences between the proteins. Contains two PS00583 pfkB family of carbohydrate kinases signatures 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS53;inference=protein motif:PROSITE:PS00583;locus_tag=Rv3507;product=PE-PGRS family protein PE_PGRS53;protein_id=CCP46329.1;transl_table=11
AL123456.3	EMBL	gene	3931005	3936710	.	+	.	ID=gene-Rv3508;Name=PE_PGRS54;gbkey=Gene;gene=PE_PGRS54;gene_biotype=protein_coding;locus_tag=Rv3508
AL123456.3	EMBL	CDS	3931005	3936710	.	+	0	ID=cds-CCP46330.1;Parent=gene-Rv3508;Dbxref=EnsemblGenomes-Gn:Rv3508,EnsemblGenomes-Tr:CCP46330,InterPro:IPR000084,NCBI_GP:CCP46330.1;Name=CCP46330.1;Note=Rv3508%2C (MTV023.15)%2C len: 1901 aa. PE_PGRS54%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan %26 Delogu 2002)%2C similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. downstream O53559|Rv3514|MTV023.21 (1489 aa)%2CFASTA scores: opt: 6598%2C E(): 0%2C (71.05%25 identity in 1533 aa overlap). Equivalent to AAK47971 from Mycobacterium tuberculosis strain CDC1551 (1384 aa) but shorter 13 aa and with some minor differences between the proteins. Contains five PS00583 pfkB family of carbohydrate kinases signatures 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS54;inference=protein motif:PROSITE:PS00583;locus_tag=Rv3508;product=PE-PGRS family protein PE_PGRS54;protein_id=CCP46330.1;transl_table=11
AL123456.3	EMBL	gene	3936877	3938424	.	-	.	ID=gene-Rv3509c;Name=ilvX;gbkey=Gene;gene=ilvX;gene_biotype=protein_coding;locus_tag=Rv3509c
AL123456.3	EMBL	CDS	3936877	3938424	.	-	0	ID=cds-CCP46331.1;Parent=gene-Rv3509c;Dbxref=EnsemblGenomes-Gn:Rv3509c,EnsemblGenomes-Tr:CCP46331,GOA:O53554,InterPro:IPR011766,InterPro:IPR012001,InterPro:IPR029061,NCBI_GP:CCP46331.1;Name=CCP46331.1;Note=Rv3509c%2C (MTV023.16)%2C len: 515 aa. Probable ilvX%2Cacetohydroxyacid synthase%2C equivalent to Mycobacterium leprae protein described as Acetolactate synthase I%2C valine sensitive%2C large subunit Q49865|ILVX|ILVI1|B229_C3_222 (515 aa)%2C FASTA scores: opt: 2762%2C E(): 8.8e-145%2C (82.9%25 identity in 515 aa overlap). Also similar to various enzymes (principally acetohydroxyacid/acetolactate synthases) e.g. Q9AB41|CC0393 thiamine-pyrophosphate-requiring enzyme from Caulobacter crescentus (512 aa)%2C FASTA scores: opt: 1572%2C E(): 2.8e-79%2C(50.95%25 identity in 514 aa overlap)%3B BAB50432|MLL3567 acetolactate synthase I from Rhizobium loti (Mesorhizobium loti) (517 aa)%2C FASTA scores: opt: 1440%2C E(): 5.2e-72%2C(47.9%25 identity in 548 aa overlap)%3B P20906|MDLC_PSEPU benzoylformate decarboxylase from Pseudomonas putida (528 aa)%2C FASTA scores: opt: 356%2C E(): 2.5e-12%2C (28.1%25 identity in 530 aa overlap)%3B Q9L123|SC6D11.33c putative decarboxylase from Streptomyces coelicolor (526 aa)%2C FASTA scores: opt: 325%2C E(): 1.3e-10%2C (33.2%25 identity in 530 aa overlap)%3B Q9RDF9|SCC57A.40c putative acetolactate synthase from Streptomyces coelicolor (564 aa)%2C FASTA scores: opt: 304%2C E(): 1.9e-09%2C (28.55%25 identity in 550 aa overlap)%3B P94783 valine-sensitive acetohydroxy acid synthase from Citrobacter freundii (561 aa)%2C FASTA scores: opt: 278%2C E(): 5.1e-08%2C (25.8%25 identity in 550 aa overlap)%3B Q42767|AHAS acetohydroxyacid synthase from Gossypium hirsutum (Upland cotton) (659 aa)%2C FASTA scores: opt: 278%2C E(): 5.8e-08%2C(26.15%25 identity in 558 aa overlap)%3B etc. Note that other Mycobacterium tuberculosis proteins%2C e.g. O53250|MTV012.17c|ILVB_MYCTU|Rv3003c|MT3083|MTV012.17c%2C showbetter similarity to Acetolactate synthase I. Similar to other enzymes which require TPP. Cofactor: thiamin pyrophosphate (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ilvX;locus_tag=Rv3509c;product=Probable acetohydroxyacid synthase IlvX (acetolactate synthase);protein_id=CCP46331.1;transl_table=11
AL123456.3	EMBL	gene	3938421	3939257	.	-	.	ID=gene-Rv3510c;Name=Rv3510c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3510c
AL123456.3	EMBL	CDS	3938421	3939257	.	-	0	ID=cds-CCP46332.1;Parent=gene-Rv3510c;Dbxref=EnsemblGenomes-Gn:Rv3510c,EnsemblGenomes-Tr:CCP46332,GOA:I6Y3Q7,InterPro:IPR006992,UniProtKB/TrEMBL:I6Y3Q7,NCBI_GP:CCP46332.1;Name=CCP46332.1;Note=Rv3510c%2C (MTV023.17)%2C len: 278 aa. Conserved protein%2C similar to Q50662|Rv2303c|MTCY339.06 hypothetical 34.6 KDA protein from Mycobacterium tuberculosis (307 aa)%2CFASTA scores: opt: 416%2C E(): 1.2e-19%2C (35.7%25 identity in 255 aa overlap). Middle of the putative protein highly similar to N-terminal end of Q49860|B229_C2_182 hypothetical 11.0 KDA protein from Mycobacterium leprae (95 aa)%2C FASTA scores: opt: 304%2C E(): 7.9e-13%2C (83.65%25 identity in 55 aa overlap). Also some similarity with other bacterial proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa)%2C FASTA scores: opt: 293%2C E(): 9.6e-12%2C (31.3%25 identity in 198 aa overlap)%3B Q9XDF3|NONC NONC protein from Streptomyces griseus subsp. griseus (317 aa)%2C FASTA scores: opt: 270%2C E(): 3.4e-10%2C (29.95%25 identity in 227 aa overlap)%3B Q54229|NONR macrotetrolide antibiotic-resistance protein from Streptomyces griseus (347 aa)%2C FASTA scores: opt: 270%2C E(): 3.6e-10%2C (29.95%25 identity in 227 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3510c;product=Conserved protein;protein_id=CCP46332.1;transl_table=11
AL123456.3	EMBL	gene	3939617	3941761	.	+	.	ID=gene-Rv3511;Name=PE_PGRS55;gbkey=Gene;gene=PE_PGRS55;gene_biotype=protein_coding;locus_tag=Rv3511
AL123456.3	EMBL	CDS	3939617	3941761	.	+	0	ID=cds-CCP46333.1;Parent=gene-Rv3511;Dbxref=EnsemblGenomes-Gn:Rv3511,EnsemblGenomes-Tr:CCP46333,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MWW8,NCBI_GP:CCP46333.1;Name=CCP46333.1;Note=Rv3511%2C (MTV023.18)%2C len: 714 aa. PE_PGRS55%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C 2002)%2Csimilar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 2563%2C E(): 1.5e-94%2C (59.65%25 identity in 773 aa overlap)%3B and upstream O53553|Rv3508|MTV023.15 (1901 aa)%2CFASTA scores: opt: 2455%2C E(): 3.9e-90%2C (60.4%25 identity in 737 aa overlap)%3B etc. Contains PS00583 pfkB family of carbohydrate kinases signature 1.;gbkey=CDS;gene=PE_PGRS55;inference=protein motif:PROSITE:PS00583;locus_tag=Rv3511;product=PE-PGRS family protein PE_PGRS55;protein_id=CCP46333.1;transl_table=11
AL123456.3	EMBL	gene	3941724	3944963	.	+	.	ID=gene-Rv3512;Name=PE_PGRS56;gbkey=Gene;gene=PE_PGRS56;gene_biotype=protein_coding;locus_tag=Rv3512;partial=true;start_range=.,3941724
AL123456.3	EMBL	CDS	3941724	3944963	.	+	0	ID=cds-CCP46334.1;Parent=gene-Rv3512;Dbxref=EnsemblGenomes-Gn:Rv3512,EnsemblGenomes-Tr:CCP46334,GOA:Q6MWW7,UniProtKB/TrEMBL:Q6MWW7,NCBI_GP:CCP46334.1;Name=CCP46334.1;Note=Rv3512%2C (MTV023.19)%2C len: 1079 aa. PE_PGRS56%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA scores: opt: 3688%2C E(): 4.5e-130%2C (53.95%25 identity in 1136 aa overlap)%3B and downstream O53559|Rv3514|MTV023.21 (1489 aa)%2C FASTA scores: opt: 3611%2C E(): 3.6e-127%2C (53.15%25 identity in 1195 aa overlap)%3B etc. Frameshifted PGRS protein%2C could be continuation of upstream MTV023.18%2C but no error could be found.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS56;locus_tag=Rv3512;partial=true;product=PE-PGRS family protein PE_PGRS56;protein_id=CCP46334.1;start_range=.,3941724;transl_table=11
AL123456.3	EMBL	gene	3945092	3945748	.	-	.	ID=gene-Rv3513c;Name=fadD18;gbkey=Gene;gene=fadD18;gene_biotype=protein_coding;locus_tag=Rv3513c
AL123456.3	EMBL	CDS	3945092	3945748	.	-	0	ID=cds-CCP46335.1;Parent=gene-Rv3513c;Dbxref=EnsemblGenomes-Gn:Rv3513c,EnsemblGenomes-Tr:CCP46335,GOA:I6YGC8,InterPro:IPR025110,UniProtKB/TrEMBL:I6YGC8,NCBI_GP:CCP46335.1;Name=CCP46335.1;Note=Rv3513c%2C (MTV023.20c)%2C len: 218 aa (Start uncertain). Probable fadD18%2C fatty-acid-CoA synthetase (C-terminal fragment)%2C almost identical to C-terminal end of downstream O53560|FADD19|Rv3515c|MTV023.22c%2C probably result of partial gene duplication. Also similar at the C-terminus to other fatty-acid-CoA synthetases e.g. Q9EXL2|FADD from Streptomyces griseus (540 aa)%2C FASTA scores: opt: 586%2C E(): 1.2e-28%2C (52.45%25 identity in 185 aa overlap)%3B AAB87139|MIG medium chain acyl-CoA synthetase precursor from Mycobacterium avium (550 aa)%2C FASTA scores: opt: 506%2C E(): 9.5e-24%2C (50.0%25 identity in 150 aa overlap)%3B Q9A7C3|CC1801 putative 4-coumarate--CoA ligase from Caulobacter crescentus (561 aa)%2C FASTA scores: opt: 430%2CE(): 4.4e-19%2C (45.75%25 identity in 153 aa overlap)%3B Q9KDT0|BH1131 acid-CoA ligase from Bacillus halodurans (546 aa)%2C FASTA scores: opt: 338%2C E(): 1.9e-13%2C (38.05%25 identity in 142 aa overlap)%3B Q9RTR4|DR1692 long-chain fatty acid--CoA ligase from Deinococcus radiodurans (584 aa)%2CFASTA scores: opt: 331%2C E(): 5.3e-13%2C (35.15%25 identity in 145 aa overlap)%3B etc.;gbkey=CDS;gene=fadD18;locus_tag=Rv3513c;product=Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP46335.1;transl_table=11
AL123456.3	EMBL	repeat_region	3945098	3945597	.	-	.	ID=id-Rv3513c;Note=500 bp perfect direct repeat 2%3B second copy at 3950830..3951329.;gbkey=repeat_region;gene=fadD18;locus_tag=Rv3513c
AL123456.3	EMBL	gene	3945794	3950263	.	+	.	ID=gene-Rv3514;Name=PE_PGRS57;gbkey=Gene;gene=PE_PGRS57;gene_biotype=protein_coding;locus_tag=Rv3514
AL123456.3	EMBL	CDS	3945794	3950263	.	+	0	ID=cds-CCP46336.1;Parent=gene-Rv3514;Dbxref=EnsemblGenomes-Gn:Rv3514,EnsemblGenomes-Tr:CCP46336,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MWW6,NCBI_GP:CCP46336.1;Name=CCP46336.1;Note=Rv3514%2C (MTV023.21)%2C len: 1489 aa. PE_PGRS57%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C similar to others from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. AAK47971 (1715 aa) FASTA scores: opt: 6940%2CE(): 0%2C (67.0%25 identity in 1713 aa overlap)%3B and upstream O53553|YZ08_MYCTU|Rv3508|MTV023.15 (1901 aa)%2C FASTA scores: opt: 6598%2CE(): 0%2C (71.05%25 identity in 1533 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS57;inference=protein motif:PROSITE:PS00583;locus_tag=Rv3514;product=PE-PGRS family protein PE_PGRS57;protein_id=CCP46336.1;transl_table=11
AL123456.3	EMBL	gene	3950824	3952470	.	-	.	ID=gene-Rv3515c;Name=fadD19;gbkey=Gene;gene=fadD19;gene_biotype=protein_coding;locus_tag=Rv3515c
AL123456.3	EMBL	CDS	3950824	3952470	.	-	0	ID=cds-CCP46337.1;Parent=gene-Rv3515c;Dbxref=EnsemblGenomes-Gn:Rv3515c,EnsemblGenomes-Tr:CCP46337,GOA:P9WQ51,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,NCBI_GP:CCP46337.1;Name=CCP46337.1;Note=Rv3515c%2C (MTV023.22c)%2C len: 548 aa. fadD19%2Cfatty-acid-CoA synthetase%2C similar (or with similarity) to many e.g. Q9EXL2|FADD FADD protein from Streptomyces griseus (540 aa)%2C FASTA scores: opt: 1449%2C E(): 1.5e-81%2C(46.0%25 identity in 535 aa overlap)%3B AAB87139|MIG medium chain acyl-CoA synthetase precursor from Mycobacterium avium (550 aa)%2C FASTA scores: opt: 1226%2C E(): 7.6e-68%2C(40.7%25 identity in 543 aa overlap)%3B Q9A7C3|CC1801 putative 4-coumarate--CoA ligase from Caulobacter crescentus (561 aa)%2C FASTA scores: opt: 979%2C E(): 1.2e-52%2C (34.05%25 identity in 531 aa overlap)%3B O28502|AF1772 long-chain-fatty-acid--CoA ligase (FADD-7) from Archaeoglobus fulgidus (569 aa)%2C FASTA scores: opt: 560%2CE(): 6.9e-27%2C (29.3%25 identity in 543 aa overlap)%3B Q9A8N2|CC1321 long-chain-fatty-acid--CoA ligase from Caulobacter crescentus (583 aa)%2C FASTA scores: opt: 544%2CE(): 6.7e-26%2C (27.2%25 identity in 518 aa overlap)%3B P29212|LCFA_ECOLI|FADD|OLDD|B1805 long-chain-fatty-acid--CoA ligase from Escherichia coli strain K12 (561 aa)%2C FASTA scores: opt: 460%2C E(): 4e-22%2C(26.3%25 identity in 567 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Note that upstream MTV023.20c|Rv3513c|fadD18 is identical to C-terminal part of FADD19|Rv3515c|MTV023.22c (probably result of partial gene duplication).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD19;inference=protein motif:PROSITE:PS00455;locus_tag=Rv3515c;product=Fatty-acid-CoA ligase FadD19 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP46337.1;transl_table=11
AL123456.3	EMBL	repeat_region	3950830	3951329	.	-	.	ID=id-Rv3515c;Note=500 bp perfect direct repeat 1%3B second copy at 3945098..3945597.;gbkey=repeat_region;gene=fadD19;locus_tag=Rv3515c
AL123456.3	EMBL	gene	3952544	3953335	.	+	.	ID=gene-Rv3516;Name=echA19;gbkey=Gene;gene=echA19;gene_biotype=protein_coding;locus_tag=Rv3516
AL123456.3	EMBL	CDS	3952544	3953335	.	+	0	ID=cds-CCP46338.1;Parent=gene-Rv3516;Dbxref=EnsemblGenomes-Gn:Rv3516,EnsemblGenomes-Tr:CCP46338,GOA:O53561,InterPro:IPR001753,InterPro:IPR029045,UniProtKB/TrEMBL:O53561,NCBI_GP:CCP46338.1;Name=CCP46338.1;Note=Rv3516%2C (MTV023.23)%2C len: 263 aa. Possible echA19%2Cenoyl-CoA hydratase%2C similar to other e.g. Q9ZHG2|ECHA1 from Rhodococcus fascians (275 aa) FASTA scores: opt: 613%2CE(): 6.4e-32%2C (45.15%25 identity in 259 aa overlap)%3B P76082|PAAF_ECOLI|B1393 from Escherichia coli strain K12 (255 aa)%2C FASTA scores: opt: 523%2C E(): 3.3e-26%2C (33.6%25 identity in 256 aa overlap)%3B Q9I393|PA1629 from Pseudomonas aeruginosa (261 aa)%2C FASTA scores: opt: 475%2C E(): 3.8e-23%2C(36.85%25 identity in 247 aa overlap)%3B etc. Also similar to many carnitine racemases eg BAB52369|MLL6015 from Rhizobium loti (Mesorhizobium loti) (257 aa)%2C FASTA scores: opt: 546%2CE(): 1.1e-27%2C (36.65%25 identity in 251 aa overlap). Similar to several putative enoyl-CoA hydratases from Mycobacterium tuberculosis%2C e.g. P96404|ECHA1|Rv0222|MTCY08D5.17 (262 aa)%2C FASTA scores: opt: 630%2C E(): 5.1e-33%2C (44.5%25 identity in 254 aa overlap)%3B and O53783|ECHA5|Rv0675|MTV040.03 (263 aa) FASTA scores: opt: 499%2C E(): 1.1e-24%2C (40.5%25 identity in 252 aa overlap). Could belong to the enoyl-CoA hydratase/isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA19;locus_tag=Rv3516;product=Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP46338.1;transl_table=11
AL123456.3	EMBL	gene	3953431	3954270	.	+	.	ID=gene-Rv3517;Name=Rv3517;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3517
AL123456.3	EMBL	CDS	3953431	3954270	.	+	0	ID=cds-CCP46339.1;Parent=gene-Rv3517;Dbxref=EnsemblGenomes-Gn:Rv3517,EnsemblGenomes-Tr:CCP46339,GOA:O53562,InterPro:IPR025159,UniProtKB/TrEMBL:O53562,NCBI_GP:CCP46339.1;Name=CCP46339.1;Note=Rv3517%2C (MTV023.24)%2C len: 279 aa. Hypothetical protein%2C similar to several hypothetical mycobacterial proteins e.g. P71763|Rv1482c|MTCY277.03c from Mycobacterium tuberculosis strain H37Rv (339 aa) (alias AAK45794|MT1529 from Mycobacterium tuberculosis strain CDC1551 (292 aa) but longer) FASTA scores: opt: 1040%2C E(): 3.7e-60%2C (59.0%25 identity in 273 aa overlap)%3B O07396|MAV346 from Mycobacterium avium (346 aa) FASTA scores: opt: 1018%2C E(): 1e-58%2C (57.2%25 identity in 278 aa overlap)%3B O53421|Rv1073|MTV017.26 from Mycobacterium tuberculosis strain H37Rv (283 aa)%2C FASTA scores: opt: 903%2C E(): 2.4e-51%2C (48.0%25 identity in 277 aa overlap)%3B Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa) FASTA scores: opt: 158%2C E(): 0.0015%2C (41.8%25 identity in 55 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3517;product=Conserved hypothetical protein;protein_id=CCP46339.1;transl_table=11
AL123456.3	EMBL	gene	3954325	3955521	.	-	.	ID=gene-Rv3518c;Name=cyp142;gbkey=Gene;gene=cyp142;gene_biotype=protein_coding;locus_tag=Rv3518c
AL123456.3	EMBL	CDS	3954325	3955521	.	-	0	ID=cds-CCP46340.1;Parent=gene-Rv3518c;Dbxref=EnsemblGenomes-Gn:Rv3518c,EnsemblGenomes-Tr:CCP46340,GOA:P9WPL5,InterPro:IPR001128,InterPro:IPR002397,InterPro:IPR017972,PDB:2XKR,NCBI_GP:CCP46340.1;Name=CCP46340.1;Note=Rv3518c%2C (MTV023.25c)%2C len: 398 aa. Probable cyp142%2Ccytochrome P450 monoxygenase%2C member of Cytochrome P450 family and similar to many e.g. Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 798%2C E(): 2e-43%2C (36.7%25 identity in 403 aa overlap)%3B P33271|CPXK_SACER|CYP107B1 from Saccharopolyspora erythraea (Streptomyces erythraeus) (405 aa)%2C FASTA scores: opt: 725%2CE(): 9.1e-39%2C (37.1%25 identity in 407 aa overlap)%3B Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa)%2C FASTA scores: opt: 691%2C E(): 1.3e-36%2C (37.2%25 identity in 317 aa overlap)%3B etc. Also similar to Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA scores: opt: 692%2C E(): 1.2e-36%2C (36.8%25 identity in 402 aa overlap). Equivalent to AAK47979 from Mycobacterium tuberculosis strain CDC1551 (372 aa) but longer 26 aa. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp142;inference=protein motif:PROSITE:PS00086;locus_tag=Rv3518c;product=Probable cytochrome P450 monooxygenase 142 Cyp142;protein_id=CCP46340.1;transl_table=11
AL123456.3	EMBL	gene	3955550	3956260	.	+	.	ID=gene-Rv3519;Name=Rv3519;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3519
AL123456.3	EMBL	CDS	3955550	3956260	.	+	0	ID=cds-CCP46341.1;Parent=gene-Rv3519;Dbxref=EnsemblGenomes-Gn:Rv3519,EnsemblGenomes-Tr:CCP46341,GOA:O53564,InterPro:IPR010451,InterPro:IPR023375,UniProtKB/TrEMBL:O53564,NCBI_GP:CCP46341.1;Name=CCP46341.1;Note=Rv3519%2C (MTV023.26)%2C len: 236 aa (start uncertain). Unknown protein. The C-terminal end is highly similar to N-terminal end of AAK47980|MT3620 hypothetical 7.8 KDA protein from Mycobacterium tuberculosis strain CDC1551 (73 aa)%2C FASTA scores: opt: 279%2C E(): 9.4e-12%2C (95.65%25 identity in 46 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3519;product=Unknown protein;protein_id=CCP46341.1;transl_table=11
AL123456.3	EMBL	gene	3956325	3957368	.	-	.	ID=gene-Rv3520c;Name=Rv3520c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3520c
AL123456.3	EMBL	CDS	3956325	3957368	.	-	0	ID=cds-CCP46342.1;Parent=gene-Rv3520c;Dbxref=EnsemblGenomes-Gn:Rv3520c,EnsemblGenomes-Tr:CCP46342,GOA:O53565,InterPro:IPR011251,InterPro:IPR019951,NCBI_GP:CCP46342.1;Name=CCP46342.1;Note=Rv3520c%2C (MTV023.27c)%2C len: 347 aa. Possible coenzyme F420-dependent oxidoreductase%2C equivalent to Q9CCV8|ML0348 possible coenzyme F420-dependent oxidoreductase from Mycobacterium leprae (350 aa)%2C FASTA scores: opt: 2029%2C E(): 9.1e-120%2C (86.85%25 identity in 342 aa overlap). Similar to many coenzyme F420-dependent enzymes (and other proteins) e.g. Q9AD98|SCI52.11c putative ATP/GTP-binding protein from Streptomyces coelicolor (351 aa)%2C FASTA scores: opt: 859%2C E(): 1.6e-46%2C (41.9%25 identity in 346 aa overlap)%3B Q9X7Y1|SC6A5.35 putative oxidoreductase from Streptomyces coelicolor (341 aa)%2C FASTA scores: opt: 800%2C E(): 7.9e-43%2C (38.95%25 identity in 339 aa overlap)%3B Q9ZA30|GRA-ORF29 putative FMN-dependent monooxygenase from Streptomyces violaceoruber (343 aa)%2C FASTA scores: opt: 354%2C E(): 6.7e-15%2C (34.2%25 identity in 336 aa overlap)%3B Q49598|mer coenzyme F420-dependent N5%2CN10-methylenetetrahydromethanopterin reductase from Methanopyrus kandleri (349 aa)%2C FASTA scores: opt: 283%2CE(): 1.9e-10%2C (26.75%25 identity in 329 aa overlap)%3B Q58929|mer|MJ1534 F420-dependent methylenetetrahydromethanopterin reductase from Methanococcus jannaschii (331 aa)%2C FASTA scores: opt: 227%2CE(): 5.8e-07%2C (26.35%25 identity in 334 aa overlap)%3B O27784|MTH1752 coenzyme F420-dependent N5%2CN10-methylene tetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (321 aa)%2C FASTA scores: opt: 207%2C E(): 1e-05%2C (27.4%25 identity in 336 aa overlap)%3B etc. Also similar to Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 hypothetical 37.3 KDA protein from Mycobacterium tuberculosis (340 aa)%2C FASTA scores: opt: 313%2C E(): 2.5e-12%2C (28.0%25 identity in 311 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3520c;product=Possible coenzyme F420-dependent oxidoreductase;protein_id=CCP46342.1;transl_table=11
AL123456.3	EMBL	gene	3957521	3958432	.	+	.	ID=gene-Rv3521;Name=Rv3521;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3521
AL123456.3	EMBL	CDS	3957521	3958432	.	+	0	ID=cds-CCP46343.1;Parent=gene-Rv3521;Dbxref=EnsemblGenomes-Gn:Rv3521,EnsemblGenomes-Tr:CCP46343,InterPro:IPR002878,InterPro:IPR012340,UniProtKB/TrEMBL:O53566,NCBI_GP:CCP46343.1;Name=CCP46343.1;Note=Rv3521%2C (MTV023.28)%2C len: 303 aa. Conserved hypothetical protein%2C similar to (although longer than) other conserved hypothetical proteins e.g. O29296|AF0966 from Archaeoglobus fulgidus (176 aa)%2C FASTA scores: opt: 286%2C E(): 5.4e-11%2C (31.15%25 identity in 170 aa overlap)%3B O30036|AF0203 from Archaeoglobus fulgidus (149 aa) FASTA scores: opt: 259%2C E(): 2.3e-09%2C (33.8%25 identity in 142 aa overlap)%3B O29297|AF0965 from Archaeoglobus fulgidus (154 aa)%2C FASTA scores: opt: 241%2C E(): 3.2e-08%2C (31.4%25 identity in 137 aa overlap)%3B Q9Y995|APE2390 from Aeropyrum pernix (157 aa)%2C FASTA scores: opt: 204%2C E(): 6.8e-06%2C (27.45%25 identity in 153 aa overlap)%3B BAB60424|TVG1322512 from Thermoplasma volcanium (164 aa)%2C FASTA scores: opt: 183%2CE(): 0.00015%2C (29.75%25 identity in 148 aa overlap)%3B etc. Equivalent to AAK47982 from Mycobacterium tuberculosis strain CDC1551 (334 aa) but shorter 31 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3521;product=Conserved hypothetical protein;protein_id=CCP46343.1;transl_table=11
AL123456.3	EMBL	gene	3958448	3959512	.	+	.	ID=gene-Rv3522;Name=ltp4;gbkey=Gene;gene=ltp4;gene_biotype=protein_coding;locus_tag=Rv3522
AL123456.3	EMBL	CDS	3958448	3959512	.	+	0	ID=cds-CCP46344.1;Parent=gene-Rv3522;Dbxref=EnsemblGenomes-Gn:Rv3522,EnsemblGenomes-Tr:CCP46344,GOA:O53567,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,UniProtKB/TrEMBL:O53567,NCBI_GP:CCP46344.1;Name=CCP46344.1;Note=Rv3522%2C (MTV023.29)%2C len: 354 aa. Possible ltp4%2Clipid carrier protein or keto acyl-CoA thiolase%2C similar to several e.g. O30103|AF0134 3-ketoacyl-CoA thiolase (ACAB-4) from Archaeoglobus fulgidus (398 aa) FASTA scores: opt: 352%2C E(): 5.3e-15%2C (30.45%25 identity in 381 aa overlap)%3B O29295|AF0967 3-ketoacyl-CoA thiolase (ACAB-9) from Archaeoglobus fulgidus (400 aa) FASTA scores: opt: 312%2CE(): 1.8e-12%2C (28.05%25 identity in 367 aa overlap)%3B O29294|AF0968 3-ketoacyl-CoA thiolase (ACAB-10) from Archaeoglobus fulgidus (388 aa)%2C FASTA scores: opt: 293%2CE(): 2.9e-11%2C (25.9%25 identity in 309 aa overlap)%3B O58409|PH0676 long hypothetical nonspecific lipid-transfer protein (acethyl CoA synthetase) from Pyrococcus horikoshii (389 aa)%2C FASTA scores: opt: 292%2C E(): 3.3e-11%2C (25.8%25 identity in 368 aa overlap)%3B Q9Y9A3|APE2382 long hypothetical non specific lipid-transfer protein from Aeropyrum pernix (360 aa) FASTA scores: opt: 270%2C E(): 7.8e-10%2C (27.25%25 identity in 363 aa overlap)%3B Q9YDI4|APE0929 long hypothetical nonspecific lipid-transfer protein from Aeropyrum pernix (400 aa)%2C FASTA scores: opt: 258%2C E(): 4.9e-09%2C (26.45%25 identity in 306 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;gene=ltp4;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3522;product=Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4;protein_id=CCP46344.1;transl_table=11
AL123456.3	EMBL	gene	3959529	3960713	.	+	.	ID=gene-Rv3523;Name=ltp3;gbkey=Gene;gene=ltp3;gene_biotype=protein_coding;locus_tag=Rv3523
AL123456.3	EMBL	CDS	3959529	3960713	.	+	0	ID=cds-CCP46345.1;Parent=gene-Rv3523;Dbxref=EnsemblGenomes-Gn:Rv3523,EnsemblGenomes-Tr:CCP46345,GOA:I6YGD8,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,UniProtKB/TrEMBL:I6YGD8,NCBI_GP:CCP46345.1;Name=CCP46345.1;Note=Rv3523%2C (MTCY03C7.33c)%2C len: 394 aa. Probable ltp3%2Clipid carrier protein or keto acyl-CoA thiolase%2C similar to several e.g. O30037|AF0202 3-ketoacyl-CoA thiolase (ACAB-6) from Archaeoglobus fulgidus (380 aa) FASTA scores: opt: 782%2C E(): 1.7e-40%2C (38.35%25 identity in 386 aa overlap)%3B Q9Y9A1|APE2384 long hypothetical non specific lipid-transfer protein (acethyl CoA synthetase) from Aeropyrum pernix (394 aa)%2C FASTA scores: opt: 626%2C E(): 5.9e-31%2C (35.75%25 identity in 386 aa overlap)%3B BAB59210|TVG0067506 lipid transfer protein from Thermoplasma volcanium (390 aa)%2C FASTA scores: opt: 591%2CE(): 8.1e-29%2C (34.35%25 identity in 384 aa overlap)%3B Q9YDI4|APE0929 long hypothetical nonspecific lipid-transfer protein from Aeropyrum pernix (400 aa) FASTA scores: opt: 588%2C E(): 1.3e-28%2C (31.6%25 identity in 408 aa overlap)%3B O30104|AF0133 3-ketoacyl-CoA thiolase (ACAB-3) from Archaeoglobus fulgidus (411 aa) FASTA scores: opt: 583%2CE(): 2.6e-28%2C (39.8%25 identity in 412 aa overlap)%3B O29811|AF0438 3-ketoacyl-CoA thiolase (ACAB-8) from Archaeoglobus fulgidus (387 aa)%2C FASTA scores: opt: 574%2CE(): 8.8e-28%2C (30.95%25 identity in 388 aa overlap)%3B etc.;gbkey=CDS;gene=ltp3;locus_tag=Rv3523;product=Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3;protein_id=CCP46345.1;transl_table=11
AL123456.3	EMBL	gene	3960755	3961786	.	+	.	ID=gene-Rv3524;Name=Rv3524;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3524
AL123456.3	EMBL	CDS	3960755	3961786	.	+	0	ID=cds-CCP46346.1;Parent=gene-Rv3524;Dbxref=EnsemblGenomes-Gn:Rv3524,EnsemblGenomes-Tr:CCP46346,InterPro:IPR001258,InterPro:IPR011042,InterPro:IPR013017,UniProtKB/TrEMBL:I6X7J6,NCBI_GP:CCP46346.1;Name=CCP46346.1;Note=Rv3524%2C (MTCY03C7.32c)%2C len: 343 aa. Probable conserved membrane protein%2C showing some similarity to C-terminal part of putative Mycobacterium tuberculosis proteins O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.08 serine-threonine protein kinase PknD (664 aa) FASTA scores: opt: 727%2C E(): 8.3e-36%2C (45.3%25 identity in 298 aa overlap)%3B O53893|Rv0980c|MTV044.08c PGRS-family protein (457 aa)%2CFASTA scores: opt: 208%2C E(): 4.4e-05%2C (33.75%25 identity in 166 aa overlap)%3B and O53891|Rv0978c|MTV044.06c PGRS-family protein (331 aa) FASTA scores: opt: 153%2C E(): 0.062%2C(30.75%25 identity in 117 aa overlap). Contains PS00237 G-protein coupled receptors signature.;gbkey=CDS;inference=protein motif:PROSITE:PS00237;locus_tag=Rv3524;product=Probable conserved membrane protein;protein_id=CCP46346.1;transl_table=11
AL123456.3	EMBL	gene	3961800	3962324	.	-	.	ID=gene-Rv3525c;Name=Rv3525c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3525c
AL123456.3	EMBL	CDS	3961800	3962324	.	-	0	ID=cds-CCP46347.1;Parent=gene-Rv3525c;Dbxref=EnsemblGenomes-Gn:Rv3525c,EnsemblGenomes-Tr:CCP46347,InterPro:IPR001451,InterPro:IPR011004,UniProtKB/TrEMBL:I6YCB9,NCBI_GP:CCP46347.1;Name=CCP46347.1;Note=Rv3525c%2C (MTCY3C7.31)%2C len: 174 aa. Possible siderophore-binding protein%2C similar to ferripyochelin binding proteins (and related) e.g. Q9RSN5|DR2089 ferripyochelin-binding protein from Deinococcus radiodurans (240 aa)%2C FASTA scores: opt: 472%2C E(): 3.3e-21%2C (46.9%25 identity in 162 aa overlap)%3B O59257|PH1591 long hypothetical ferripyochelin binding protein from Pyrococcus horikoshii (173 aa)%2C FASTA scores: opt: 431%2C E(): 6.7e-19%2C(40.0%25 identity in 170 aa overlap)%3B Q9V158|FBP|PAB0393 ferripyochelin binding protein from Pyrococcus abyssi (173 aa)%2C FASTA scores: opt: 429%2C E(): 8.9e-19%2C (39.4%25 identity in 170 aa overlap)%3B BAB47820|MLR0180 ferripyochelin binding protein-like from Rhizobium loti (Mesorhizobium loti) (175 aa)%2C FASTA scores: opt: 415%2C E(): 6.1e-18%2C (42.55%25 identity in 141 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3525c;product=Possible siderophore-binding protein;protein_id=CCP46347.1;transl_table=11
AL123456.3	EMBL	gene	3962439	3963599	.	+	.	ID=gene-Rv3526;Name=kshA;gbkey=Gene;gene=kshA;gene_biotype=protein_coding;locus_tag=Rv3526
AL123456.3	EMBL	CDS	3962439	3963599	.	+	0	ID=cds-CCP46348.1;Parent=gene-Rv3526;Dbxref=EnsemblGenomes-Gn:Rv3526,EnsemblGenomes-Tr:CCP46348,GOA:P71875,InterPro:IPR017941,PDB:2ZYL,PDB:4QCK,NCBI_GP:CCP46348.1;Name=CCP46348.1;Note=Rv3526%2C (MTCY03C7.30c)%2C len: 386 aa. kshA%2C oxygenase component of 3-ketosteroid-9-alpha-hydroxylase%2C highly similar%2C except in C-terminus (also longer 69 aa)%2C to O69348|ORF12 protein (function unknown) from Rhodococcus erythropolis (316 aa) FASTA scores: opt: 1137%2C E(): 6.9e-65%2C (59.6%25 identity in 250 aa overlap). Also some similarity with several aminopyrrolnitrin oxidases (PRND proteins%2C involved in the pathway for pyrrolnitrin biosynthesis%2C a secondary metabolite derived from tryptophan which has strong anti-fungal activity) e.g. Q9RPG0|PRND from Myxococcus fulvus (379 aa)%2C FASTA scores: opt: 322%2C E(): 4.4e-13%2C (25.85%25 identity in 352 aa overlap)%3B Q9RPG4|PRND from Burkholderia cepacia (Pseudomonas cepacia) (373 aa) FASTA scores: opt: 306%2C E(): 4.5e-12%2C (25.2%25 identity in 373 aa overlap)%3B P95483|PRND from Pseudomonas fluorescens (363 aa)%2C FASTA scores: opt: 305%2C E(): 5.1e-12%2C (25.0%25 identity in 372 aa overlap)%3B etc. And also some similarity to other putative enzymes like dioxygenases%2C oxidases%2C vanillate O-demethyl oxygenase%2Cetc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kshA;locus_tag=Rv3526;product=Oxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA;protein_id=CCP46348.1;transl_table=11
AL123456.3	EMBL	gene	3963605	3964054	.	+	.	ID=gene-Rv3527;Name=Rv3527;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3527
AL123456.3	EMBL	CDS	3963605	3964054	.	+	0	ID=cds-CCP46349.1;Parent=gene-Rv3527;Dbxref=EnsemblGenomes-Gn:Rv3527,EnsemblGenomes-Tr:CCP46349,UniProtKB/TrEMBL:I6XHG6,NCBI_GP:CCP46349.1;Name=CCP46349.1;Note=Rv3527%2C (MTCY03C7.29c)%2C len: 149 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3527;product=Hypothetical protein;protein_id=CCP46349.1;transl_table=11
AL123456.3	EMBL	gene	3964479	3965192	.	-	.	ID=gene-Rv3528c;Name=Rv3528c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3528c
AL123456.3	EMBL	CDS	3964479	3965192	.	-	0	ID=cds-CCP46350.1;Parent=gene-Rv3528c;Dbxref=EnsemblGenomes-Gn:Rv3528c,EnsemblGenomes-Tr:CCP46350,InterPro:IPR029063,UniProtKB/TrEMBL:I6YGE4,NCBI_GP:CCP46350.1;Name=CCP46350.1;Note=Rv3528c%2C (MTCY03C7.28)%2C len: 237 aa. Unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3528c;product=Unknown protein;protein_id=CCP46350.1;transl_table=11
AL123456.3	EMBL	gene	3965884	3967038	.	-	.	ID=gene-Rv3529c;Name=Rv3529c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3529c
AL123456.3	EMBL	CDS	3965884	3967038	.	-	0	ID=cds-CCP46351.1;Parent=gene-Rv3529c;Dbxref=EnsemblGenomes-Gn:Rv3529c,EnsemblGenomes-Tr:CCP46351,InterPro:IPR027417,UniProtKB/TrEMBL:I6YCC4,NCBI_GP:CCP46351.1;Name=CCP46351.1;Note=Rv3529c%2C (MTCY03C7.27)%2C len: 384 aa. Conserved hypothetical protein%2C showing some similarity to Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 hypothetical 46.1 KDA protein from Mycobacterium tuberculosis (388 aa) FASTA scores: opt: 261%2C E(): 1.6e-09%2C (27.25%25 identity in 253 aa overlap).;gbkey=CDS;locus_tag=Rv3529c;product=Conserved hypothetical protein;protein_id=CCP46351.1;transl_table=11
AL123456.3	EMBL	gene	3967038	3967820	.	-	.	ID=gene-Rv3530c;Name=Rv3530c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3530c
AL123456.3	EMBL	CDS	3967038	3967820	.	-	0	ID=cds-CCP46352.1;Parent=gene-Rv3530c;Dbxref=EnsemblGenomes-Gn:Rv3530c,EnsemblGenomes-Tr:CCP46352,GOA:I6Y3S9,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:I6Y3S9,NCBI_GP:CCP46352.1;Name=CCP46352.1;Note=Rv3530c%2C (MTCY03C7.26)%2C len: 260 aa. Possible oxidoreductase%2C similar to various oxidoreductases and hypothetical proteins e.g. BAB53258|Q987E5|MLL7083 probable oxidoreductase from Rhizobium loti (Mesorhizobium loti) (258 aa)%2C FASTA scores: opt: 405%2C E(): 5.3e-18%2C (33.45%25 identity in 263 aa overlap)%3B Q9VNF3|CG12171 hypothetical protein from Drosophila melanogaster (Fruit fly) (257 aa)%2CFASTA scores: opt: 404%2C E(): 6.1e-18%2C (32.8%25 identity in 256 aa overlap)%3B Q9A3X5|CC3076 oxidoreductase (short-chain dehydrogenase/reductase family) from Caulobacter crescentus (254 aa)%2C FASTA scores: opt: 400%2C E(): 1.1e-17%2C (31.0%25 identity in 255 aa overlap)%3B BAB50080|MLR3115 dehydrogenase from Rhizobium loti (Mesorhizobium loti) (259 aa)%2C FASTA scores: opt: 393%2C E(): 3e-17%2C (31.9%25 identity in 254 aa overlap)%3B Q9F5J1|SIM-NJ1|SIMD2 putative 3-keto-acyl-reductase from Streptomyces antibioticus (273 aa)%2C FASTA scores: opt: 388%2C E(): 6.3e-17%2C (31.6%25 identity in 250 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3530c;product=Possible oxidoreductase;protein_id=CCP46352.1;transl_table=11
AL123456.3	EMBL	gene	3967817	3968944	.	-	.	ID=gene-Rv3531c;Name=Rv3531c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3531c
AL123456.3	EMBL	CDS	3967817	3968944	.	-	0	ID=cds-CCP46353.1;Parent=gene-Rv3531c;Dbxref=EnsemblGenomes-Gn:Rv3531c,EnsemblGenomes-Tr:CCP46353,InterPro:IPR010621,UniProtKB/TrEMBL:I6XHH2,NCBI_GP:CCP46353.1;Name=CCP46353.1;Note=Rv3531c%2C (MTCY03C7.25)%2C len: 375 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3531c;product=Hypothetical protein;protein_id=CCP46353.1;transl_table=11
AL123456.3	EMBL	gene	3969343	3970563	.	+	.	ID=gene-Rv3532;Name=PPE61;gbkey=Gene;gene=PPE61;gene_biotype=protein_coding;locus_tag=Rv3532
AL123456.3	EMBL	CDS	3969343	3970563	.	+	0	ID=cds-CCP46354.1;Parent=gene-Rv3532;Dbxref=EnsemblGenomes-Gn:Rv3532,EnsemblGenomes-Tr:CCP46354,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP46354.1;Name=CCP46354.1;Note=Rv3532%2C (MTCY03C7.24c)%2C len: 406 aa. PPE61%2C Member of the Mycobacterium tuberculosis PPE protein family%2Csimilar to many%2C e.g. O53956|Rv1807|MTV049.29 (403 aa)%2CFASTA scores: opt: 954%2C E(): 1.1e-43%2C (44.1%25 identity in 417 aa overlap);gbkey=CDS;gene=PPE61;locus_tag=Rv3532;product=PPE family protein PPE61;protein_id=CCP46354.1;transl_table=11
AL123456.3	EMBL	gene	3970705	3972453	.	-	.	ID=gene-Rv3533c;Name=PPE62;gbkey=Gene;gene=PPE62;gene_biotype=protein_coding;locus_tag=Rv3533c
AL123456.3	EMBL	CDS	3970705	3972453	.	-	0	ID=cds-CCP46355.1;Parent=gene-Rv3533c;Dbxref=EnsemblGenomes-Gn:Rv3533c,EnsemblGenomes-Tr:CCP46355,InterPro:IPR000030,InterPro:IPR002989,NCBI_GP:CCP46355.1;Name=CCP46355.1;Note=Rv3533c%2C (MTCY03C7.23)%2C len: 582 aa. PPE62%2C Member of the Mycobacterium tuberculosis PPE protein family%2Csimilar to many%2C e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: opt: 2289%2C E(): 2.3e-95%2C (63.5%25 identity in 600 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;gbkey=CDS;gene=PPE62;locus_tag=Rv3533c;product=PPE family protein PPE62;protein_id=CCP46355.1;transl_table=11
AL123456.3	EMBL	gene	3972552	3973592	.	-	.	ID=gene-Rv3534c;Name=hsaF;gbkey=Gene;gene=hsaF;gene_biotype=protein_coding;locus_tag=Rv3534c
AL123456.3	EMBL	CDS	3972552	3973592	.	-	0	ID=cds-CCP46356.1;Parent=gene-Rv3534c;Dbxref=EnsemblGenomes-Gn:Rv3534c,EnsemblGenomes-Tr:CCP46356,GOA:P9WMK5,InterPro:IPR000891,InterPro:IPR012425,InterPro:IPR013785,InterPro:IPR017629,PDB:4JN6,NCBI_GP:CCP46356.1;Name=CCP46356.1;Note=Rv3534c%2C (MTCY03C7.22)%2C len: 346 aa. Probable hsaF%2C4-hydroxy-2-oxovalerate aldolase%2C highly similar to others e.g. P51015|BPHI_PSESP from Pseudomonas sp. strain LB400 (346 aa)%2C FASTA scores: opt: 1150%2C E(): 2.3e-61%2C (51.35%25 identity in 331 aa overlap)%3B Q52040|BPHX3 from Pseudomonas pseudoalcaligenes (346 aa)%2C FASTA scores: opt: 1147%2C E(): 3.5e-61%2C (51.35%25 identity in 331 aa overlap)%3B P51017|NAHM_PSEPU from Pseudomonas putida (346 aa)%2C FASTA scores: opt: 1145%2C E(): 4.7e-61%2C (50.9%25 identity in 330 aa overlap) (see citation below)%3B P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa)%2C FASTA scores: opt: 1133%2C E(): 2.4e-60%2C (52.0%25 identity in 327 aa overlap)%3B O24833|ATDG from Acinetobacter sp (340 aa)%2C FASTA scores: opt: 1132%2C E(): 2.7e-60%2C (50.45%25 identity in 331 aa overlap)%3B etc. Note that also highly similar to Q9ZI56|NAHM 2-oxo-4-hydroxypentanoate aldolase from Pseudomonas stutzeri (Pseudomonas perfectomarina) (346 aa) FASTA scores: opt: 1168%2C E(): 2e-62%2C (51.05%25 identity in 331 aa overlap) (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsaF;locus_tag=Rv3534c;product=Probable 4-hydroxy-2-oxovalerate aldolase (HOA);protein_id=CCP46356.1;transl_table=11
AL123456.3	EMBL	gene	3973589	3974500	.	-	.	ID=gene-Rv3535c;Name=hsaG;gbkey=Gene;gene=hsaG;gene_biotype=protein_coding;locus_tag=Rv3535c
AL123456.3	EMBL	CDS	3973589	3974500	.	-	0	ID=cds-CCP46357.1;Parent=gene-Rv3535c;Dbxref=EnsemblGenomes-Gn:Rv3535c,EnsemblGenomes-Tr:CCP46357,GOA:P9WQH3,InterPro:IPR000534,InterPro:IPR003361,InterPro:IPR015426,InterPro:IPR016040,PDB:4JN6,NCBI_GP:CCP46357.1;Name=CCP46357.1;Note=Rv3535c%2C (MTCY03C7.21)%2C len: 303 aa. Probable hsaG%2Cacetaldehyde dehydrogenase%2C highly similar to many e.g. BAB62056|TDNI from Pseudomonas putida (302 aa)%2C FASTA scores: opt: 1159%2C E(): 1.5e-62%2C (60.45%25 identity in 301 aa overlap)%3B Q9ZI57|NAHO from Pseudomonas stutzeri (Pseudomonas perfectomarina) (307 aa) FASTA scores: opt: 1151%2C E(): 4.6e-62%2C (59.55%25 identity in 299 aa overlap)%3B Q9F9I4|CDOI from Comamonas sp. JS765 (302 aa) FASTA scores: opt: 1136%2C E(): 3.6e-61%2C (60.15%25 identity in 301 aa overlap)%3B Q51962|NAHO from Pseudomonas putida (307 aa)%2CFASTA scores: opt: 1133%2C E(): 5.6e-61%2C (58.55%25 identity in 299 aa overlap) (see citation below)%3B P77580|MHPF_ECOLI|MHPF|MHPE|B0351 from Escherichia coli strain K12 (316 aa)%2C FASTA scores: opt: 1040%2C E(): 2.2e-55%2C(56.85%25 identity in 306 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsaG;locus_tag=Rv3535c;product=Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]);protein_id=CCP46357.1;transl_table=11
AL123456.3	EMBL	gene	3974511	3975296	.	-	.	ID=gene-Rv3536c;Name=hsaE;gbkey=Gene;gene=hsaE;gene_biotype=protein_coding;locus_tag=Rv3536c
AL123456.3	EMBL	CDS	3974511	3975296	.	-	0	ID=cds-CCP46358.1;Parent=gene-Rv3536c;Dbxref=EnsemblGenomes-Gn:Rv3536c,EnsemblGenomes-Tr:CCP46358,GOA:I6XHH5,InterPro:IPR002529,InterPro:IPR011234,UniProtKB/TrEMBL:I6XHH5,NCBI_GP:CCP46358.1;Name=CCP46358.1;Note=Rv3536c%2C (MTCY03C7.20)%2C len: 261 aa. Probable hsaE%2Chydratase%2C 2-oxo-hepta-3-ene-1%2C7-dioate hydratase or 2-keto-4-pentenoate hydratase. Indeed%2C highly similar to many 2-oxo-hepta-3-ene-1%2C7-dioate hydratases e.g. Q9CKS2|HPAH|PM1534 from Pasteurella multocida (267 aa) FASTA scores: opt: 743%2C E(): 1.5e-39%2C (45.5%25 identity in 266 aa overlap) Q9RZ31|DRA0122 from Deinococcus radiodurans (268 aa)%2C FASTA scores: opt: 709%2C E(): 2e-37%2C (45.5%25 identity in 266 aa overlap)%3B Q9HWQ4|HPCG|PA4127 from Pseudomonas aeruginosa (267 aa)%2C FASTA scores: opt: 703%2CE(): 4.8e-37%2C (45.1%25 identity in 266 aa overlap)%3B Q46982|HPAH|HPCG from Escherichia colis strain ATCC 11105 (267 aa)%2C FASTA scores: opt: 679%2C E(): 1.6e-35%2C (41.35%25 identity in 266 aa overlap)%3B etc. But also highly similar to many 2-keto-4-pentenoate hydratases (2-hydroxypentadienoic acidhydratases) e.g. Q9LAF7|PHED from Bacillus thermoglucosidasius (258 aa)%2C FASTA scores: opt: 698%2C E(): 9.7e-37%2C (42.45%25 identity in 252 aa overlap)%3B Q52442|BPHH from Pseudomonas sp (260 aa) FASTA scores: opt: 675%2C E(): 2.7e-35%2C (41.4%25 identity in 251 aa overlap)%3B P77608|MHPD_ECOLI|B0350 from Escherichia coli strain K12 (269 aa)%2C FASTA scores: opt: 674%2C E(): 3.2e-35%2C(42.75%25 identity in 255 aa overlap)%3B Q52038|BPHX1 from Pseudomonas pseudoalcaligenes (260 aa)%2C FASTA scores: opt: 663%2C E(): 1.5e-34%2C (40.6%25 identity in 251 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsaE;locus_tag=Rv3536c;product=Probable hydratase;protein_id=CCP46358.1;transl_table=11
AL123456.3	EMBL	gene	3975369	3977060	.	+	.	ID=gene-Rv3537;Name=kstD;gbkey=Gene;gene=kstD;gene_biotype=protein_coding;locus_tag=Rv3537
AL123456.3	EMBL	CDS	3975369	3977060	.	+	0	ID=cds-CCP46359.1;Parent=gene-Rv3537;Dbxref=EnsemblGenomes-Gn:Rv3537,EnsemblGenomes-Tr:CCP46359,GOA:P71864,InterPro:IPR003953,InterPro:IPR027477,NCBI_GP:CCP46359.1;Name=CCP46359.1;Note=Rv3537%2C (MTCY03C7.19c)%2C len: 563 aa. Probable kstD%2Cdehydrogenase%2C similar to many dehydrogenases or hypothetical proteins e.g. Q9I1M6|PA2243 hypothetical protein from Pseudomonas aeruginosa (577 aa)%2C FASTA scores: opt: 984%2C E(): 1.2e-48%2C (34.75%25 identity in 573 aa overlap)%3B Q06401|3O1D_COMTE 3-oxosteroid 1-dehydrogenase from Comamonas testosteroni (Pseudomonas testosteroni) (573 aa)%2C FASTA scores: opt: 955%2C E(): 5.5e-47%2C (33.05%25 identity in 590 aa overlap)%3B Q9RA02|KSTD1 3-ketosteroid dehydrogenase from Rhodococcus erythropolis (510 aa)%2C FASTA scores: opt: 631%2C E(): 1.4e-28%2C (39.15%25 identity in 557 aa overlap)%3B P77815|KSDD 3-ketosteroid-1-dehydrogenase from Nocardioides simplex (Arthrobacter simplex) (515 aa)%2C FASTA scores: opt: 469%2C E(): 2.4e-19%2C (35.45%25 identity in 564 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kstD;locus_tag=Rv3537;product=Probable dehydrogenase;protein_id=CCP46359.1;transl_table=11
AL123456.3	EMBL	gene	3977062	3977922	.	+	.	ID=gene-Rv3538;Name=Rv3538;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3538
AL123456.3	EMBL	CDS	3977062	3977922	.	+	0	ID=cds-CCP46360.1;Parent=gene-Rv3538;Dbxref=EnsemblGenomes-Gn:Rv3538,EnsemblGenomes-Tr:CCP46360,GOA:Q6MWW2,InterPro:IPR002539,InterPro:IPR029069,UniProtKB/TrEMBL:Q6MWW2,NCBI_GP:CCP46360.1;Name=CCP46360.1;Note=Rv3538%2C (MTCY03C7.18c)%2C len: 286 aa. Probable double hotdog R-specific hydratase%2C substrate unknown%2C shows structural similarity to six others in Mycobacterium tuberculosis (see Castell et al (2005) below) especially Rv3389. Probable dehydrogenase%2C similar to Q9L009|SCC30.12c putative dehydrogenase from Streptomyces coelicolor (333 aa)%2C FASTA scores: opt: 842%2C E(): 3.6e-44%2C (48.4%25 identity in 285 aa overlap)%3B and similar to C-terminal part of other (principally estradiol 17 beta-dehydrogenases/17-beta-hydroxysteroid dehydrogenases) e.g. P70540 peroxisomal multifunctional enzyme type II (SDR family) from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 622%2C E(): 1.9e-30%2C (37.45%25 identity in 283 aa overlap)%3B or P70523|MPF-2 multifunctional protein 2 (SDR family) (beta-oxidation protein displaying 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity) from Rattus norvegicus (Rat) (734 aa)%2C FASTA scores: opt: 616%2C E(): 4.3e-30%2C (37.1%25 identity in 283 aa overlap)%3B P51659|DHB4_HUMAN|HSD17B4|EDH17B4 estradiol 17 beta-dehydrogenase from Homo sapiens (Human) (736 aa)%2CFASTA scores: opt: 614%2C E(): 5.7e-30%2C (35.9%25 identity in 284 aa overlap)%3B P97852|DHB4_RAT|HSD17B4|EDH17B4 estradiol 17 beta-dehydrogenase from Rattus norvegicus (Rat) (735 aa) FASTA scores: opt: 613%2C E(): 6.6e-30%2C (37.1%25 identity in 283 aa overlap)%3B Q9DBM3|HSD17B4 estradiol 17 beta-dehydrogenase from Mus musculus (Mouse) (735 aa) FASTA scores: opt: 611%2C E(): 8.7e-30%2C (36.5%25 identity in 285 aa overlap)%3B etc. Also similar to Q11198|Rv3389c|MTV004.47c hypothetical 30.3 KDA protein from Mycobacterium tuberculosis (290 aa)%2C FASTA scores: opt: 609%2C E(): 5.3e-30%2C (39.65%25 identity in 285 aa overlap). Note that previously known as ufaA2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3538;product=Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.;protein_id=CCP46360.1;transl_table=11
AL123456.3	EMBL	gene	3978059	3979498	.	+	.	ID=gene-Rv3539;Name=PPE63;gbkey=Gene;gene=PPE63;gene_biotype=protein_coding;locus_tag=Rv3539
AL123456.3	EMBL	CDS	3978059	3979498	.	+	0	ID=cds-CCP46361.1;Parent=gene-Rv3539;Dbxref=EnsemblGenomes-Gn:Rv3539,EnsemblGenomes-Tr:CCP46361,GOA:P9WHX5,InterPro:IPR000030,InterPro:IPR013228,NCBI_GP:CCP46361.1;Name=CCP46361.1;Note=Rv3539%2C (MTCY03C7.17c)%2C len: 479 aa. PPE63%2C Member of the Mycobacterium tuberculosis PPE protein family%2Csimilar to many e.g. O53949|Rv1800|MTV049.22 (655 aa)%2CFASTA scores: opt: 914%2C E(): 7.3e-47%2C (37.55%25 identity in 490 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE63;locus_tag=Rv3539;product=PPE family protein PPE63;protein_id=CCP46361.1;transl_table=11
AL123456.3	EMBL	gene	3979499	3980659	.	-	.	ID=gene-Rv3540c;Name=ltp2;gbkey=Gene;gene=ltp2;gene_biotype=protein_coding;locus_tag=Rv3540c
AL123456.3	EMBL	CDS	3979499	3980659	.	-	0	ID=cds-CCP46362.1;Parent=gene-Rv3540c;Dbxref=EnsemblGenomes-Gn:Rv3540c,EnsemblGenomes-Tr:CCP46362,GOA:I6Y3T7,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,UniProtKB/TrEMBL:I6Y3T7,NCBI_GP:CCP46362.1;Name=CCP46362.1;Note=Rv3540c%2C (MTCY03C7.16)%2C len: 386 aa. Probable ltp2%2Clipid-transfer protein or keto acyl-CoA thiolase%2C similar to several e.g. Q9X4X2|DITF DITF protein (hypothetical protein%2C similar to non-specific lipid-transfer protein and 3-ketoacyl-CoA thiolase) from Pseudomonas abietaniphila (397 aa)%2C FASTA scores: opt: 665%2C E(): 5.3e-34%2C (33.4%25 identity in 392 aa overlap)%3B O30255|AF2416 3-ketoacyl-CoA thiolase (ACAB-12) from Archaeoglobus fulgidus (384 aa)%2CFASTA scores: opt: 496%2C E(): 1.6e-23%2C (30.35%25 identity in 389 aa overlap)%3B O28978|AF1291 3-ketoacyl-CoA thiolase (ACAB-11) from Archaeoglobus fulgidus (392 aa)%2C FASTA scores: opt: 494%2C E(): 2.2e-23%2C (30.6%25 identity in 379 aa overlap)%3B O26884|MTH793 lipid-transfer protein (sterol or nonspecific) from Methanobacterium thermoautotrophicum (383 aa)%2C FASTA scores: opt: 487%2C E(): 5.9e-23%2C (30.4%25 identity in 388 aa overlap)%3B etc.;gbkey=CDS;gene=ltp2;locus_tag=Rv3540c;product=Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2;protein_id=CCP46362.1;transl_table=11
AL123456.3	EMBL	gene	3980659	3981048	.	-	.	ID=gene-Rv3541c;Name=Rv3541c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3541c
AL123456.3	EMBL	CDS	3980659	3981048	.	-	0	ID=cds-CCP46363.1;Parent=gene-Rv3541c;Dbxref=EnsemblGenomes-Gn:Rv3541c,EnsemblGenomes-Tr:CCP46363,InterPro:IPR029069,UniProtKB/TrEMBL:I6XHI0,NCBI_GP:CCP46363.1;Name=CCP46363.1;Note=Rv3541c%2C (MTCY03C7.15)%2C len: 129 aa. Conserved protein%2C showing some similarity to Q9CBJ7|ML1909 hypothetical protein from Mycobacterium leprae (142 aa) FASTA scores: opt: 110%2C E(): 1.2%2C (27.95%25 identity in 118 aa overlap)%3B and other (see also blastp results) e.g. Q9L0M3|SCD82.08 hypothetical 15.2 KDA protein from Streptomyces coelicolor (142 aa)%2C FASTA scores: opt: 127%2CE(): 0.086%2C (27.65%25 identity in 123 aa overlap). Contains PS00075 Dihydrofolate reductase signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00075;locus_tag=Rv3541c;product=Conserved protein;protein_id=CCP46363.1;transl_table=11
AL123456.3	EMBL	gene	3981045	3981980	.	-	.	ID=gene-Rv3542c;Name=Rv3542c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3542c
AL123456.3	EMBL	CDS	3981045	3981980	.	-	0	ID=cds-CCP46364.1;Parent=gene-Rv3542c;Dbxref=EnsemblGenomes-Gn:Rv3542c,EnsemblGenomes-Tr:CCP46364,InterPro:IPR002878,InterPro:IPR012340,InterPro:IPR029069,UniProtKB/TrEMBL:I6YGF8,NCBI_GP:CCP46364.1;Name=CCP46364.1;Note=Rv3542c%2C (MTCY03C7.14)%2C len: 311 aa. Hypothetical protein%2C showing some similarity to other e.g. Q58947|MJ1552 from Methanococcus jannaschii (141 aa) FASTA scores: opt: 177%2C E(): 0.00065%2C (46.65%25 identity in 60 aa overlap)%3B BAB59276|TVG0142586 from Thermoplasma volcanium (135 aa)%2C FASTA scores: opt: 175%2C E(): 0.00083%2C (35.65%25 identity in 87 aa overlap)%3B Q9HI85|TA1457 from Thermoplasma acidophilum (135 aa)%2C FASTA scores: opt: 162%2C E(): 0.0052%2C(31.8%25 identity in 107 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3542c;product=Conserved hypothetical protein;protein_id=CCP46364.1;transl_table=11
AL123456.3	EMBL	gene	3981977	3983140	.	-	.	ID=gene-Rv3543c;Name=fadE29;gbkey=Gene;gene=fadE29;gene_biotype=protein_coding;locus_tag=Rv3543c
AL123456.3	EMBL	CDS	3981977	3983140	.	-	0	ID=cds-CCP46365.1;Parent=gene-Rv3543c;Dbxref=EnsemblGenomes-Gn:Rv3543c,EnsemblGenomes-Tr:CCP46365,GOA:P71858,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P71858,NCBI_GP:CCP46365.1;Name=CCP46365.1;Note=Rv3543c%2C (MTCY03C7.13)%2C len: 387 aa. Probable fadE29%2C acyl-CoA dehydrogenase%2C similar to many e.g. Q9A8P3|CC1310 from Caulobacter crescentus (404 aa)%2C FASTA scores: opt: 624%2C E(): 9.4e-32%2C (32.75%25 identity in 400 aa overlap)%3B Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa)%2C FASTA scores: opt: 550%2C E(): 3.9e-27%2C (33.7%25 identity in 350 aa overlap)%3B O28976|AF1293 from Archaeoglobus fulgidus (384 aa)%2C FASTA scores: opt: 529%2C E(): 8.1e-26%2C(30.0%25 identity in 393 aa overlap)%3B etc. Also similar to other from Mycobacterium tuberculosis e.g. O53549|FADE26|Rv3504|MTV023.11 (400 aa)%2C FASTA scores: opt: 1031%2C E(): 2.8e-57%2C (46.0%25 identity in 402 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE29;locus_tag=Rv3543c;product=Probable acyl-CoA dehydrogenase FadE29;protein_id=CCP46365.1;transl_table=11
AL123456.3	EMBL	gene	3983125	3984144	.	-	.	ID=gene-Rv3544c;Name=fadE28;gbkey=Gene;gene=fadE28;gene_biotype=protein_coding;locus_tag=Rv3544c
AL123456.3	EMBL	CDS	3983125	3984144	.	-	0	ID=cds-CCP46366.1;Parent=gene-Rv3544c;Dbxref=EnsemblGenomes-Gn:Rv3544c,EnsemblGenomes-Tr:CCP46366,GOA:P71857,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P71857,NCBI_GP:CCP46366.1;Name=CCP46366.1;Note=Rv3544c%2C (MTCY03C7.12)%2C len: 339 aa. Probable fadE28%2C acyl-CoA dehydrogenase%2C similar to many e.g. Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa)%2CFASTA scores: opt: 334%2C E(): 5.1e-13%2C (27.65%25 identity in 329 aa overlap)%3B Q9A5G8|CC2479 from Caulobacter crescentus (344 aa)%2C FASTA scores: opt: 278%2C E(): 1.2e-09%2C (26.95%25 identity in 319 aa overlap)%3B O29813|AF0436 from Archaeoglobus fulgidus (382 aa) FASTA scores: opt: 205%2CE(): 3.5e-05%2C (24.75%25 identity in 384 aa overlap)%3B etc. Also similar to other from Mycobacterium tuberculosis e.g. O53550|FADE27|Rv3505|MTV023.12 (373 aa) FASTA scores: opt: 497%2C E(): 7e-23%2C (30.3%25 identity in 343 aa overlap)%3B and to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 probable acyl-CoA dehydrogenase from Mycobacterium leprae (389 aa) FASTA scores: opt: 165%2C E(): 0.0012%2C (25.2%25 identity in 345 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE28;locus_tag=Rv3544c;product=Probable acyl-CoA dehydrogenase FadE28;protein_id=CCP46366.1;transl_table=11
AL123456.3	EMBL	gene	3984144	3985445	.	-	.	ID=gene-Rv3545c;Name=cyp125;gbkey=Gene;gene=cyp125;gene_biotype=protein_coding;locus_tag=Rv3545c
AL123456.3	EMBL	CDS	3984144	3985445	.	-	0	ID=cds-CCP46367.1;Parent=gene-Rv3545c;Dbxref=EnsemblGenomes-Gn:Rv3545c,EnsemblGenomes-Tr:CCP46367,GOA:P9WPP1,InterPro:IPR001128,InterPro:IPR002397,PDB:2X5L,PDB:2X5W,PDB:2XC3,PDB:2XN8,PDB:3IVY,PDB:3IW0,PDB:3IW1,PDB:3IW2,NCBI_GP:CCP46367.1;Name=CCP46367.1;Note=Rv3545c%2C (MT3649%2C MTCY03C7.11)%2C len: 433 aa. Probable cyp125%2C cytochrome P-450%2C similar to others e.g. Q59723|LINC|CYP111 from Pseudomonas incognita (406 aa)%2CFASTA scores: opt: 831%2C E(): 8e-45%2C (34.75%25 identity in 406 aa overlap)%3B Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces coelicolor (411 aa)%2C FASTA scores: opt: 694%2C E(): 3.3e-36%2C(32.35%25 identity in 417 aa overlap)%3B Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa) FASTA scores: opt: 664%2CE(): 2.5e-34%2C (34.15%25 identity in 413 aa overlap)%3B O08469|CPXY_BACSU|CYPA|CYP107J1 from Bacillus subtilis (410 aa)%2C FASTA scores: opt: 579%2C E(): 5.6e-29%2C (30.05%25 identity in 366 aa overlap)%3B etc. Also similar to other from Mycobacterium tuberculosis e.g. Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA scores: opt: 1040%2C E(): 6.1e-58%2C (40.75%25 identity in 432 aa overlap). Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp125;locus_tag=Rv3545c;product=Probable cytochrome P450 125 Cyp125;protein_id=CCP46367.1;transl_table=11
AL123456.3	EMBL	gene	3985557	3986732	.	+	.	ID=gene-Rv3546;Name=fadA5;gbkey=Gene;gene=fadA5;gene_biotype=protein_coding;locus_tag=Rv3546
AL123456.3	EMBL	CDS	3985557	3986732	.	+	0	ID=cds-CCP46368.1;Parent=gene-Rv3546;Dbxref=EnsemblGenomes-Gn:Rv3546,EnsemblGenomes-Tr:CCP46368,GOA:I6XHI4,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020613,InterPro:IPR020616,InterPro:IPR020617,UniProtKB/TrEMBL:I6XHI4,NCBI_GP:CCP46368.1;Name=CCP46368.1;Note=Rv3546%2C (MTCY03C7.10c)%2C len: 391 aa. Probable fadA5%2Cacetyl-CoA acetyltransferase%2C similar to many e.g. Q9AA29|CC0779 from Caulobacter crescentus (390 aa)%2C FASTA scores: opt: 999%2C E(): 7.1e-54%2C (43.5%25 identity in 400 aa overlap)%3B Q9K783|BH3487 from Bacillus halodurans (393 aa)%2CFASTA scores: opt: 843%2C E(): 2.6e-44%2C (37.45%25 identity in 398 aa overlap)%3B Q9RRK9|DR2480 from Deinococcus radiodurans (399 aa)%2C FASTA scores: opt: 826%2C E(): 2.8e-43%2C (38.15%25 identity in 396 aa overlap)%3B P45369|THIL_CHRVI|PHBA from Chromatium vinosum (394 aa) FASTA scores: opt: 790%2C E(): 4.5e-41%2C (39.4%25 identity in 401 aa overlap)%3B etc. Contains PS00737 Thiolases signature 2. Belongs to the thiolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadA5;inference=protein motif:PROSITE:PS00737;locus_tag=Rv3546;product=Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase);protein_id=CCP46368.1;transl_table=11
AL123456.3	EMBL	gene	3986844	3987299	.	+	.	ID=gene-Rv3547;Name=ddn;gbkey=Gene;gene=ddn;gene_biotype=protein_coding;locus_tag=Rv3547
AL123456.3	EMBL	CDS	3986844	3987299	.	+	0	ID=cds-CCP46369.1;Parent=gene-Rv3547;Dbxref=EnsemblGenomes-Gn:Rv3547,EnsemblGenomes-Tr:CCP46369,GOA:P9WP15,InterPro:IPR004378,InterPro:IPR012349,PDB:3R5L,PDB:3R5P,PDB:3R5R,PDB:3R5W,NCBI_GP:CCP46369.1;Name=CCP46369.1;Note=Rv3547%2C (MTCY03C7.09c)%2C len: 151 aa. Ddn%2Cdeazaflavin-dependent nitroreducatse (See Singh et al.%2C2008). Similar to hypothetical proteins e.g. O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa)%2C FASTA scores: opt: 353%2CE(): 6.3e-17%2C (42.55%25 identity in 134 aa overlap)%3B Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa) FASTA scores: opt: 290%2C E(): 2.1e-12%2C (38.5%25 identity in 122 aa overlap) (similarity in N-terminus for this protein)%3B BAB52932|Q988L5|MLL6688 from Rhizobium loti (Mesorhizobium loti) (148 aa)%2C FASTA scores: opt: 105%2C E(): 3%2C (26.75%25 identity in 86 aa overlap). Also similar to mycobacterial hypothetical proteins e.g. Q9ZH81 from Mycobacterium paratuberculosis (144 aa)%2C FASTA scores: opt: 366%2C E(): 8.2e-18%2C (43.9%25 identity in 123 aa overlap)%3B and Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c from Mycobacterium tuberculosis (148 aa)%2C FASTA scores: opt: 330%2C E(): 2.2e-15%2C (39.75%25 identity in 151 aa overlap)%3B etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ddn;locus_tag=Rv3547;product=Deazaflavin-dependent nitroreductase Ddn;protein_id=CCP46369.1;transl_table=11
AL123456.3	EMBL	gene	3987382	3988296	.	-	.	ID=gene-Rv3548c;Name=Rv3548c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3548c
AL123456.3	EMBL	CDS	3987382	3988296	.	-	0	ID=cds-CCP46370.1;Parent=gene-Rv3548c;Dbxref=EnsemblGenomes-Gn:Rv3548c,EnsemblGenomes-Tr:CCP46370,GOA:P71853,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:P71853,NCBI_GP:CCP46370.1;Name=CCP46370.1;Note=Rv3548c%2C (MTCY03C7.08)%2C len: 304 aa. Probable short-chain dehydrogenase/reductase%2C highly similar to various dehydrogenases/reductases (generally belonging to the SDR family) e.g. Q9I4V1|PA1023 from Pseudomonas aeruginosa (305 aa)%2C FASTA scores: opt: 446%2C E(): 1.7e-17%2C(43.75%25 identity in 256 aa overlap)%3B Q9A6K0|CC2093 from Caulobacter crescentus (301 aa) FASTA scores: opt: 437%2CE(): 5.3e-17%2C (42.8%25 identity in 257 aa overlap)%3B Q9HYH8|PA3427 from Pseudomonas aeruginosa (303 aa)%2C FASTA scores: opt: 399%2C E(): 6.5e-15%2C (45.5%25 identity in 257 aa overlap)%3B Q9VXJ0|CG3415 from Drosophila melanogaster (Fruit fly) (598 aa)%2C FASTA scores: opt: 402%2C E(): 7.5e-15%2C (40.7%25 identity in 285 aa overlap)%3B etc. Also highly similar to O53547|Rv3502c|MTV023.09c putative short-chain type dehydrogenase/reductase from (317 aa) FASTA scores: opt: 739%2C E(): 1.6e-33%2C (45.15%25 identity in 310 aa overlap)%3B and other proteins from Mycobacterium tuberculosis. Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv3548c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP46370.1;transl_table=11
AL123456.3	EMBL	gene	3988319	3989098	.	-	.	ID=gene-Rv3549c;Name=Rv3549c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3549c
AL123456.3	EMBL	CDS	3988319	3989098	.	-	0	ID=cds-CCP46371.1;Parent=gene-Rv3549c;Dbxref=EnsemblGenomes-Gn:Rv3549c,EnsemblGenomes-Tr:CCP46371,GOA:I6YCE1,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,UniProtKB/TrEMBL:I6YCE1,NCBI_GP:CCP46371.1;Name=CCP46371.1;Note=Rv3549c%2C (MTCY03C7.07)%2C len: 259 aa. Probable short-chain dehydrogenase/reductase%2C similar to various dehydrogenases/reductases (generally belong to the SDR family) e.g. Q9UKU3 from Homo sapiens (Human) (270 aa)%2CFASTA scores: opt: 451%2C E(): 4.8e-21%2C (38.05%25 identity in 247 aa overlap)%3B Q9S274|SCI28.09c from Streptomyces coelicolor (234 aa)%2C FASTA scores: opt: 439%2C E(): 2.4e-20%2C(36.8%25 identity in 231 aa overlap)%3B Q9PFI6|XF0671 from Xylella fastidiosa (247 aa)%2C FASTA scores: opt: 437%2C E(): 3.4e-20%2C (37.7%25 identity in 252 aa overlap)%3B etc. Also highly similar to O33308|FABG5|Rv2766c|MTV002.31c alcohol dehydrogenase (SDR family) from Mycobacterium tuberculosis (260 aa)%2C FASTA scores: opt: 504%2C E(): 2.3e-24%2C (38.5%25 identity in 244 aa overlap). Contains PS00061 Short-chain alcohol dehydrogenase family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;gbkey=CDS;inference=protein motif:PROSITE:PS00061;locus_tag=Rv3549c;product=Probable short-chain type dehydrogenase/reductase;protein_id=CCP46371.1;transl_table=11
AL123456.3	EMBL	gene	3989153	3989896	.	+	.	ID=gene-Rv3550;Name=echA20;gbkey=Gene;gene=echA20;gene_biotype=protein_coding;locus_tag=Rv3550
AL123456.3	EMBL	CDS	3989153	3989896	.	+	0	ID=cds-CCP46372.1;Parent=gene-Rv3550;Dbxref=EnsemblGenomes-Gn:Rv3550,EnsemblGenomes-Tr:CCP46372,GOA:I6Y3U6,InterPro:IPR001753,InterPro:IPR029045,UniProtKB/TrEMBL:I6Y3U6,NCBI_GP:CCP46372.1;Name=CCP46372.1;Note=Rv3550%2C (MTCY03C7.06c)%2C len: 247 aa. Probable echA20%2C enoyl-CoA hydratase%2C similar to others e.g. Q9A7B0|CC1814 from Caulobacter crescentus (275 aa)%2C FASTA scores: opt: 488%2C E(): 3.5e-24%2C (36.4%25 identity in 239 aa overlap)%3B O84978|PHAA from Pseudomonas putida (293 aa)%2CFASTA scores: opt: 383%2C E(): 2e-17%2C (33.85%25 identity in 254 aa overlap)%3B BAB48479|Q98LI4|MLL1009 from Rhizobium loti (Mesorhizobium loti) (258 aa)%2C FASTA scores: opt: 378%2C E(): 3.8e-17%2C (21.45%25 identity in 231 aa overlap)%3B etc. Could belong to the enoyl-CoA hydratase/isomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA20;locus_tag=Rv3550;product=Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP46372.1;transl_table=11
AL123456.3	EMBL	gene	3989896	3990774	.	+	.	ID=gene-Rv3551;Name=Rv3551;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3551
AL123456.3	EMBL	CDS	3989896	3990774	.	+	0	ID=cds-CCP46373.1;Parent=gene-Rv3551;Dbxref=EnsemblGenomes-Gn:Rv3551,EnsemblGenomes-Tr:CCP46373,GOA:P9WPW1,InterPro:IPR004165,NCBI_GP:CCP46373.1;Name=CCP46373.1;Note=Rv3551%2C (MTCY03C7.05c)%2C len: 292 aa. Possible CoA-transferase%2C alpha subunit%2C similar in part to other CoA-transferases e.g. Q59111|GCTA_ACIFE|GCTA glutaconate CoA-transferase subunit A (GCT large subunit) from Acidaminococcus fermentans (319 aa) FASTA scores: opt: 247%2CE(): 6.3e-09%2C (27.35%25 identity in 307 aa overlap)%3B Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa)%2C FASTA scores: opt: 222%2C E(): 2.3e-07%2C (27.55%25 identity in 243 aa overlap)%3B BAB50895|MLL4183 from Rhizobium loti (Mesorhizobium loti) (285 aa)%2C FASTA scores: opt: 206%2C E(): 2.8e-06%2C (27.4%25 identity in 281 aa overlap)%3B etc. Also some similarity with O06167|SCOA_MYCTU|RVv504c|MT2579|MTCY07A7.10c probable succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A from Mycobacterium tuberculosis (248 aa)%2C FASTA scores: opt: 210%2C E(): 1.4e-06%2C (25.5%25 identity in 247 aa overlap). Belongs to the glutaconate CoA-transferase subunit A family. Note that this putative protein may combine with the putative protein encoded by the downstream ORF Rv3552 to form a CoA-transferase that comprises two subunits.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3551;product=Possible CoA-transferase (alpha subunit);protein_id=CCP46373.1;transl_table=11
AL123456.3	EMBL	gene	3990771	3991523	.	+	.	ID=gene-Rv3552;Name=Rv3552;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3552
AL123456.3	EMBL	CDS	3990771	3991523	.	+	0	ID=cds-CCP46374.1;Parent=gene-Rv3552;Dbxref=EnsemblGenomes-Gn:Rv3552,EnsemblGenomes-Tr:CCP46374,GOA:P9WPV9,NCBI_GP:CCP46374.1;Name=CCP46374.1;Note=Rv3552%2C (MTCY03C7.03c)%2C len: 250 aa. Possible CoA-transferase%2C beta subunit%2C similar in part to other CoA-transferases e.g. Q9I6R1|PA0227 from Pseudomonas aeruginosa (260 aa)%2C FASTA scores: opt: 233%2C E(): 8.6e-08%2C(24.8%25 identity in 238 aa overlap)%3B BAB50894|MLL4181 from Rhizobium loti (Mesorhizobium loti) (264 aa)%2C FASTA scores: opt: 210%2C E(): 2.6e-06%2C (24.15%25 identity in 203 aa overlap)%3B and AAK41345|Q97Z51|GCTB from Sulfolobus solfataricus (245 aa)%2C FASTA scores: opt: 122%2C E(): 1.1%2C(25.5%25 identity in 243 aa overlap). Possibly belongs to the glutaconate CoA-transferase subunit B family. Note that this putative protein may combine with the putative protein encoded by the upstream ORF Rv3551 to form a CoA-transferase that comprises two subunits.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3552;product=Possible CoA-transferase (beta subunit);protein_id=CCP46374.1;transl_table=11
AL123456.3	EMBL	repeat_region	3991568	3991625	.	-	.	ID=id-AL123456.3:3991568..3991625;Note=58 bp Mycobacterial Interspersed Repetitive Unit%2CClass III.;gbkey=repeat_region
AL123456.3	EMBL	gene	3991621	3992688	.	+	.	ID=gene-Rv3553;Name=Rv3553;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3553
AL123456.3	EMBL	CDS	3991621	3992688	.	+	0	ID=cds-CCP46375.1;Parent=gene-Rv3553;Dbxref=EnsemblGenomes-Gn:Rv3553,EnsemblGenomes-Tr:CCP46375,GOA:P71847,InterPro:IPR004136,InterPro:IPR013785,UniProtKB/TrEMBL:P71847,NCBI_GP:CCP46375.1;Name=CCP46375.1;Note=Rv3553%2C (MTCY03C7.02c)%2C len: 355 aa. Possible oxidoreductase%2C highly similar (except in C-terminus) to Q9A327|CC3379 hypothetical protein from Caulobacter crescentus (321 aa)%2C FASTA scores: opt: 639%2C E(): 4.6e-29%2C(46.35%25 identity in 248 aa overlap)%3B and Q9WZQ7|TM0800 conserved hypothetical protein from Thermotoga maritima (314 aa)%2C FASTA scores: opt: 622%2C E(): 4.1e-28%2C (37.95%25 identity in 340 aa overlap). Also similar to two trans-2-enoyl-ACP reductases%3B Q99YD4|FABK|SPY1751 from Streptococcus pyogenes (323 aa)%2C FASTA scores: opt: 604%2CE(): 4.4e-27%2C (33.25%25 identity in 346 aa overlap)%3B and Q9FBC5|FABK from Streptococcus pneumoniae (324 aa)%2C FASTA scores: opt: 553%2C E(): 3.3e-24%2C (32.1%25 identity in 346 aa overlap)%3B and similar with several 2-nitropropane dioxygenases%2C e.g. Q9F7P8 from uncultured proteobacterium EBAC31A08 (322 aa)%2C FASTA scores: opt: 505%2C E(): 1.7e-21%2C(33.6%25 identity in 348 aa overlap)%3B Q9FMG0 (alias AAK44141) from Arabidopsis thaliana (Mouse-ear cress) (333 aa)%2C FASTA scores: opt: 489%2C E(): 1.4e-20%2C (33.15%25 identity in 341 aa overlap)%3B O28109|AF2173 (NCD2) from Archaeoglobus fulgidus (274 aa)%2C FASTA scores: opt: 456%2C E(): 8.9e-19%2C (36.3%25 identity in 237 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3553;product=Possible oxidoreductase;protein_id=CCP46375.1;transl_table=11
AL123456.3	EMBL	gene	3992685	3994742	.	+	.	ID=gene-Rv3554;Name=fdxB;gbkey=Gene;gene=fdxB;gene_biotype=protein_coding;locus_tag=Rv3554
AL123456.3	EMBL	CDS	3992685	3994742	.	+	0	ID=cds-CCP46376.1;Parent=gene-Rv3554;Dbxref=EnsemblGenomes-Gn:Rv3554,EnsemblGenomes-Tr:CCP46376,GOA:P71846,InterPro:IPR001041,InterPro:IPR001433,InterPro:IPR005804,InterPro:IPR006058,InterPro:IPR008333,InterPro:IPR012675,InterPro:IPR017927,InterPro:IPR017938,UniProtKB/TrEMBL:P71846,NCBI_GP:CCP46376.1;Name=CCP46376.1;Note=Rv3554%2C (MTCY06G11.01%2C MTCY03C7.01c)%2C len: 685 aa. Possible fdxB%2C two-domain protein%2C with ferredoxin reductase electron transfer component in C-terminal part and unknown function in N-terminal part. Indeed%2C N-terminal end is similar to O85832 hypothetical 36.1 KDA protein from Sphingomonas aromaticivorans strain F199 (catabolic plasmid pNL1) (309 aa)%2C FASTA scores: opt: 615%2C E(): 2.5e-30%2C(33.1%25 identity in 311 aa overlap)%3B and P73428|SLL1468 hypothetical 36.2 KDA protein from Synechocystis sp. strain PCC 6803 (312 aa)%2C FASTA scores: opt: 317%2C E(): 4.5e-12%2C(30.2%25 identity in 268 aa overlap). And C-terminal end is similar to Q9F9U6|PAAE protein involved in aerobic phenylacetate metabolism from Azoarcus evansii (360 aa)%2CFASTA scores: opt: 935%2C E(): 7e-50%2C (43.85%25 identity in 351 aa overlap)%3B CAC44653|PAAE|SCBAC17A6.08 putative phenylacetic acid degradation NADH oxidoreductase from Streptomyces coelicolor (368 aa)%2C FASTA scores: opt: 93%2CE(): 9.5e-50%2C (41.95%25 identity in 372 aa overlap)%3B Q9FA57|PACI ferredoxin from Azoarcus evansii (360 aa)%2CFASTA scores: opt: 925%2C E(): 2.9e-49%2C (43.3%25 identity in 351 aa overlap)%3B P76081|PAAE_ECOLI|B1392 probable phenylacetic acid degradation NADH oxidoreductase from Escherichia coli strains K12 and W (356 aa)%2C FASTA scores: opt: 910%2C E(): 2.4e-48%2C (43.05%25 identity in 353 aa overlap)%3B Q9APJ6|PAAE electron transfer protein (fragment) from Hyphomicrobium chloromethanicum (241 aa)%2C FASTA scores: opt: 404%2C E(): 1.7e-17%2C (35.45%25 identity in 234 aa overlap)%3B BAB51608|MLL5100 ferredoxin from Rhizobium loti (Mesorhizobium loti) (365 aa)%2C FASTA scores: opt: 316%2C E(): 5.8e-12%2C (28.95%25 identity in 349 aa overlap)%3B etc. C-terminus also similar to P96853|Rv3571|MTCY06G11.18 putative electron transfer protein from Mycobacterium tuberculosis (358 aa)%2C FASTA scores: opt: 450%2C E(): 3.6e-20%2C (32.95%25 identity in 358 aa overlap). Contains PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature. Belongs to the 2FE2S plant-type ferredoxin family. Cofactor: binds a 2FE-2S cluster (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fdxB;inference=protein motif:PROSITE:PS00197;locus_tag=Rv3554;product=Possible electron transfer protein FdxB;protein_id=CCP46376.1;transl_table=11
AL123456.3	EMBL	gene	3994830	3995699	.	-	.	ID=gene-Rv3555c;Name=Rv3555c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3555c
AL123456.3	EMBL	CDS	3994830	3995699	.	-	0	ID=cds-CCP46377.1;Parent=gene-Rv3555c;Dbxref=EnsemblGenomes-Gn:Rv3555c,EnsemblGenomes-Tr:CCP46377,GOA:P96837,InterPro:IPR007569,InterPro:IPR011335,InterPro:IPR025159,UniProtKB/TrEMBL:P96837,NCBI_GP:CCP46377.1;Name=CCP46377.1;Note=Rv3555c%2C (MTCY06G11.02c)%2C len: 289 aa. Conserved protein%2C highly similar to others from Mycobacterium tuberculosis e.g. O53562|AL022022|Rv3517|MTV023.24 (279 aa)%2C FASTA scores: opt: 874%2C E(): 8.3e-48%2C (49.45%25 identity in 275 aa overlap)%3B P71763|Rv1482c|MTCY277.03c (339 aa)%2CFASTA scores: opt: 755%2C E(): 3e-40%2C (45.75%25 identity in 260 aa overlap)%3B O69681|Rv3714c|MTV025.062c (296 aa)%2C FASTA scores: opt: 733%2C E(): 6.4e-39%2C (44.1%25 identity in 281 aa overlap)%3B etc. Also highly similar to other mycobacterial hypothetical proteins e.g. O07396|MAV346 from Mycobacterium avium (346 aa)%2C FASTA scores: opt: 714%2C E(): 1.1e-37%2C(44.6%25 identity in 260 aa overlap)%3B and Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa)%2CFASTA scores: opt: 130%2C E(): 0.17%2C (35.1%25 identity in 57 aa overlap) (only partial homology with this protein). Shows some similarity to P52392|NHSR_STRAS putative nosiheptide resistance regulatory protein (ORF699) from Streptomyces actuosus (233 aa)%2C FASTA scores: opt: 120%2C E(): 1.9%2C(25.25%25 identity in 194 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3555c;product=Conserved protein;protein_id=CCP46377.1;transl_table=11
AL123456.3	EMBL	gene	3995804	3996964	.	-	.	ID=gene-Rv3556c;Name=fadA6;gbkey=Gene;gene=fadA6;gene_biotype=protein_coding;locus_tag=Rv3556c
AL123456.3	EMBL	CDS	3995804	3996964	.	-	0	ID=cds-CCP46378.1;Parent=gene-Rv3556c;Dbxref=EnsemblGenomes-Gn:Rv3556c,EnsemblGenomes-Tr:CCP46378,GOA:I6XHJ3,InterPro:IPR002155,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR020613,InterPro:IPR020616,InterPro:IPR020617,UniProtKB/TrEMBL:I6XHJ3,NCBI_GP:CCP46378.1;Name=CCP46378.1;Note=Rv3556c%2C (MTCY06G11.03)%2C len: 386 aa. Probable fadA6%2C acetyl-CoA acetyltransferase%2C similar to many e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor (389 aa)%2CFASTA scores: opt: 1091%2C E(): 2.9e-58%2C (48.1%25 identity in 399 aa overlap)%3B Q9AAT4|CC0510 from Caulobacter crescentus (391 aa)%2C FASTA scores: opt: 902%2C E(): 6.6e-47%2C (40.25%25 identity in 395 aa overlap)%3B P45359|THL_CLOAB from Clostridium acetobutylicum (392 aa)%2C FASTA scores: opt: 872%2C E(): 4.2e-45%2C (37.9%25 identity in 396 aa overlap)%3B Q9I2A8|ATOB|PA2001 from Pseudomonas aeruginosa (393 aa)%2CFASTA scores: opt: 872%2C E(): 4.2e-45%2C (41.3%25 identity in 397 aa overlap)%3B etc. Contains PS00737 Thiolases signature 2. Belongs to the thiolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadA6;inference=protein motif:PROSITE:PS00737;locus_tag=Rv3556c;product=Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase);protein_id=CCP46378.1;transl_table=11
AL123456.3	EMBL	gene	3997029	3997631	.	-	.	ID=gene-Rv3557c;Name=Rv3557c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3557c
AL123456.3	EMBL	CDS	3997029	3997631	.	-	0	ID=cds-CCP46379.1;Parent=gene-Rv3557c;Dbxref=EnsemblGenomes-Gn:Rv3557c,EnsemblGenomes-Tr:CCP46379,GOA:P9WMB9,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,NCBI_GP:CCP46379.1;Name=CCP46379.1;Note=Rv3557c%2C (MTCY06G11.04c)%2C len: 200 aa. Transcriptional regulator%2C TetR family%2C similar to other e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa) FASTA scores: opt: 326%2C E(): 2.3e-14%2C (31.2%25 identity in 189 aa overlap)%3B Q9HZW2|PA2885 from Pseudomonas aeruginosa (198 aa)%2C FASTA scores: opt: 308%2C E(): 3.5e-13%2C (31.55%25 identity in 187 aa overlap)%3B Q9RFR4 from Pseudomonas fluorescens (207 aa)%2C FASTA scores: opt: 291%2C E(): 4.7e-12%2C(29.75%25 identity in 195 aa overlap)%3B Q9K8P5|BH2958 from Bacillus halodurans (215 aa)%2C FASTA scores: opt: 271%2C E(): 9.9e-11%2C (23.95%25 identity in 192 aa overlap)%3B etc. Also similar to proteins from Mycobacterium tuberculosis e.g. O53641|Rv0158|MTV032.01 (214 aa)%2C FASTA scores: opt: 232%2CE(): 3.5e-08%2C (25.5%25 identity in 192 aa overlap)%3B and O06169|Rv2506|MTCY07A7.12 (215 aa)%2C FASTA scores: opt: 215%2CE(): 4.5e-07%2C (35.15%25 identity in 148 aa overlap)%3B etc. Seems to belong to the TetR/AcrR family of transcriptional regulators.;gbkey=CDS;locus_tag=Rv3557c;product=Transcriptional regulatory protein (probably TetR-family);protein_id=CCP46379.1;transl_table=11
AL123456.3	EMBL	gene	3997980	3999638	.	+	.	ID=gene-Rv3558;Name=PPE64;gbkey=Gene;gene=PPE64;gene_biotype=protein_coding;locus_tag=Rv3558
AL123456.3	EMBL	CDS	3997980	3999638	.	+	0	ID=cds-CCP46380.1;Parent=gene-Rv3558;Dbxref=EnsemblGenomes-Gn:Rv3558,EnsemblGenomes-Tr:CCP46380,InterPro:IPR000030,InterPro:IPR002989,UniProtKB/TrEMBL:Q6MWW0,NCBI_GP:CCP46380.1;Name=CCP46380.1;Note=Rv3558%2C (MTCY06G11.05)%2C len: 552 aa. PPE64%2C Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins%2C similar to many e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa)%2C FASTA scores: opt: 1908%2C E(): 1.7e-83%2C (58.5%25 identity in 583 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C2008).;gbkey=CDS;gene=PPE64;locus_tag=Rv3558;product=PPE family protein PPE64;protein_id=CCP46380.1;transl_table=11
AL123456.3	EMBL	gene	3999647	4000435	.	-	.	ID=gene-Rv3559c;Name=Rv3559c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3559c
AL123456.3	EMBL	CDS	3999647	4000435	.	-	0	ID=cds-CCP46381.1;Parent=gene-Rv3559c;Dbxref=EnsemblGenomes-Gn:Rv3559c,EnsemblGenomes-Tr:CCP46381,GOA:I6YCF0,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,UniProtKB/TrEMBL:I6YCF0,NCBI_GP:CCP46381.1;Name=CCP46381.1;Note=Rv3559c%2C (MTCY06G11.06c)%2C len: 262 aa. Probable oxidoreductase%2C similar to various oxidoreductases e.g. Q9F5J1|SIM-NJ1|SIMD2 putative 3-keto-acyl-reductase (SDR family) from Streptomyces antibioticus (273 aa)%2C FASTA scores: opt: 510%2C E(): 2.8e-24%2C (40.15%25 identity in 249 aa overlap)%3BQ9L2C9|SC7A8.29 putative dehydrogenase from Streptomyces coelicolor (255 aa)%2C FASTA scores: opt: 500%2CE(): 1.1e-23%2C (41.4%25 identity in 239 aa overlap)%3B Q9HQ41|FABG|VNG1341G 3-oxoacyl-[acyl-carrier-protein] reductase from Halobacterium sp. strain NRC-1 (255 aa) FASTA scores: opt: 500%2C E(): 1.1e-23%2C (40.0%25 identity in 250 aa overlap)%3B etc. Also similar to oxidoreductases from Mycobacterium tuberculosis eg Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 putative oxidoreductase (247 aa)%2C FASTA scores: opt: 497%2C E(): 1.6e-23%2C (39.2%25 identity in 245 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3559c;product=Probable oxidoreductase;protein_id=CCP46381.1;transl_table=11
AL123456.3	EMBL	gene	4000432	4001589	.	-	.	ID=gene-Rv3560c;Name=fadE30;gbkey=Gene;gene=fadE30;gene_biotype=protein_coding;locus_tag=Rv3560c
AL123456.3	EMBL	CDS	4000432	4001589	.	-	0	ID=cds-CCP46382.1;Parent=gene-Rv3560c;Dbxref=EnsemblGenomes-Gn:Rv3560c,EnsemblGenomes-Tr:CCP46382,GOA:I6Y3V5,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6Y3V5,NCBI_GP:CCP46382.1;Name=CCP46382.1;Note=Rv3560c%2C (MTCY06G11.07c)%2C len: 385 aa. Probable fadE30%2C acyl-CoA dehydrogenase%2C similar to many e.g. Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa)%2C FASTA scores: opt: 845%2C E(): 1.6e-47%2C (39.2%25 identity in 388 aa overlap)%3B Q9A5G9|CC2478 from Caulobacter crescentus (407 aa)%2C FASTA scores: opt: 734%2C E(): 2.8e-40%2C (35.5%25 identity in 386 aa overlap)%3B Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa)%2C FASTA scores: opt: 656%2C E(): 3.2e-35%2C(37.9%25 identity in 351 aa overlap)%3B etc. Also similar to acyl-CoA dehydrogenases from Mycobacterium tuberculosis e.g. P95280|FADE17|Rv1934c|MTCY09F9.30 (409 aa)%2C FASTA scores: opt: 939%2C E(): 1.4e-53%2C (43.8%25 identity in 404 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;gbkey=CDS;gene=fadE30;locus_tag=Rv3560c;product=Probable acyl-CoA dehydrogenase FadE30;protein_id=CCP46382.1;transl_table=11
AL123456.3	EMBL	gene	4001637	4003160	.	+	.	ID=gene-Rv3561;Name=fadD3;gbkey=Gene;gene=fadD3;gene_biotype=protein_coding;locus_tag=Rv3561
AL123456.3	EMBL	CDS	4001637	4003160	.	+	0	ID=cds-CCP46383.1;Parent=gene-Rv3561;Dbxref=EnsemblGenomes-Gn:Rv3561,EnsemblGenomes-Tr:CCP46383,GOA:P96843,InterPro:IPR000873,InterPro:IPR020845,InterPro:IPR025110,NCBI_GP:CCP46383.1;Name=CCP46383.1;Note=Rv3561%2C (MTCY06G11.08)%2C len: 507 aa. Probable fadD3%2Cfatty-acid-CoA synthetase%2C similar to many substrate-CoA symthetases/ligases e.g. Q9KBC2|BH2006 long-chain acyl-CoA synthetase from Bacillus halodurans (513 aa)%2C FASTA scores: opt: 821%2C E(): 1.6e-43%2C (32.9%25 identity in 517 aa overlap)%3B Q9EY88|FCS feruloyl-CoA synthetase from Amycolatopsis sp. HR167 (491 aa) FASTA scores: opt: 767%2C E(): 3.5e-40%2C(37.65%25 identity in 502 aa overlap)%3B Q9ZIP5|MATB malonyl CoA synthetase from Rhizobium leguminosarum (504 aa)%2C FASTA scores: opt: 758%2C E(): 1.3e-39%2C (33.7%25 identity in 472 aa overlap)%3B Q9CD27|FADD2|ML2546 acyl-CoA synthase from Mycobacterium leprae (548 aa)%2C FASTA scores: opt: 700%2C E(): 5.6e-36%2C (31.85%25 identity in 515 aa overlap)%3B P29212|LCFA_ECOLI|FADD|OLDD|B1805 long-chain-fatty-acid--CoA ligase from Escherichia coli strain K12 (561 aa)%2C FASTA scores: opt: 532%2C E(): 6.3e-28%2C(30.0%25 identity in 533 aa overlap)%3B etc. Also similar to other from Mycobacterium tuberculosis eg O53306|FADD13|Rv3089|MTV013.10 (503 aa)%2C FASTA scores: opt: 819%2C E(): 2.1e-43%2C (35.1%25 identity in 490 aa overlap). Contains PS00455 Putative AMP-binding domain signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD3;inference=protein motif:PROSITE:PS00455;locus_tag=Rv3561;product=Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);protein_id=CCP46383.1;transl_table=11
AL123456.3	EMBL	gene	4003161	4004294	.	+	.	ID=gene-Rv3562;Name=fadE31;gbkey=Gene;gene=fadE31;gene_biotype=protein_coding;locus_tag=Rv3562
AL123456.3	EMBL	CDS	4003161	4004294	.	+	0	ID=cds-CCP46384.1;Parent=gene-Rv3562;Dbxref=EnsemblGenomes-Gn:Rv3562,EnsemblGenomes-Tr:CCP46384,GOA:I6YGH7,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6YGH7,NCBI_GP:CCP46384.1;Name=CCP46384.1;Note=Rv3562%2C (MTCY06G11.09)%2C len: 377 aa. Probable fadE31%2C acyl-CoA dehydrogenase%2C similar to many e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa)%2CFASTA scores: opt: 657%2C E(): 1.7e-34%2C (36.45%25 identity in 351 aa overlap)%3B Q9A5G9|CC2478 from Caulobacter crescentus (407 aa)%2C FASTA scores: opt: 653%2C E(): 3.2e-34%2C (33.95%25 identity in 392 aa overlap)%3B Q9EX72|MLHC from Rhodococcus erythropolis (324 aa) FASTA scores: opt: 631%2C E(): 6.5e-33%2C(36.95%25 identity in 330 aa overlap)%3B P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa)%2C FASTA scores: opt: 347%2CE(): 1e-15%2C (28.6%25 identity in 385 aa overlap)%3B etc. Also similar to other from Mycobacterium tuberculosis e.g. P96842|FADE30|Rv3560c|MTCY06G11.07c (385 aa)%2C FASTA scores: opt: 843%2C E(): 2.3e-46%2C (38.95%25 identity in 380 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE31;locus_tag=Rv3562;product=Probable acyl-CoA dehydrogenase FadE31;protein_id=CCP46384.1;transl_table=11
AL123456.3	EMBL	gene	4004291	4005250	.	+	.	ID=gene-Rv3563;Name=fadE32;gbkey=Gene;gene=fadE32;gene_biotype=protein_coding;locus_tag=Rv3563
AL123456.3	EMBL	CDS	4004291	4005250	.	+	0	ID=cds-CCP46385.1;Parent=gene-Rv3563;Dbxref=EnsemblGenomes-Gn:Rv3563,EnsemblGenomes-Tr:CCP46385,GOA:P96845,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P96845,NCBI_GP:CCP46385.1;Name=CCP46385.1;Note=Rv3563%2C (MTCY06G11.10)%2C len: 319 aa. Probable fadE32%2C acyl-CoA dehydrogenase%2C similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa)%2C FASTA scores: opt: 347%2C E(): 7.6e-14%2C (35.15%25 identity in 333 aa overlap)%3B Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa)%2C FASTA scores: opt: 300%2C E(): 5.3e-11%2C (32.4%25 identity in 349 aa overlap)%3B Q9A5G8|CC2479 from Caulobacter crescentus (344 aa)%2C FASTA scores: opt: 285%2C E(): 4.1e-10%2C(30.4%25 identity in 329 aa overlap)%3B P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa)%2C FASTA scores: opt: 230%2CE(): 1.1e-07%2C (25.5%25 identity in 357 aa overlap)%3B etc. Also similar to other from Mycobacterium tuberculosis eg P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa)%2C FASTA scores: opt: 478%2C E(): 7.6e-22%2C (32.9%25 identity in 292 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE32;locus_tag=Rv3563;product=Probable acyl-CoA dehydrogenase FadE32;protein_id=CCP46385.1;transl_table=11
AL123456.3	EMBL	gene	4005247	4006203	.	+	.	ID=gene-Rv3564;Name=fadE33;gbkey=Gene;gene=fadE33;gene_biotype=protein_coding;locus_tag=Rv3564
AL123456.3	EMBL	CDS	4005247	4006203	.	+	0	ID=cds-CCP46386.1;Parent=gene-Rv3564;Dbxref=EnsemblGenomes-Gn:Rv3564,EnsemblGenomes-Tr:CCP46386,GOA:I6YCF5,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:I6YCF5,NCBI_GP:CCP46386.1;Name=CCP46386.1;Note=Rv3564%2C (MTCY06G11.11)%2C len: 318 aa. Probable fadE33%2C acyl-CoA dehydrogenase%2C similar to others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa)%2C FASTA scores: opt: 373%2C E(): 1.9e-15%2C (34.3%25 identity in 338 aa overlap)%3B Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa)%2C FASTA scores: opt: 277%2C E(): 1.4e-09%2C (31.95%25 identity in 335 aa overlap)%3B Q9X7Y6|SC6A5.40c from Streptomyces coelicolor (395 aa)%2C FASTA scores: opt: 273%2C E(): 2.5e-09%2C(30.1%25 identity in 352 aa overlap)%3B P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa)%2C FASTA scores: opt: 478%2CE(): 7.9e-22%2C (32.9%25 identity in 292 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. P96845|FADE32|Rv3563|MTCY06G11.10 (319 aa)%2C FASTA scores: opt: 478%2C E(): 7.9e-22%2C (32.9%25 identity in 292 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE33;locus_tag=Rv3564;product=Probable acyl-CoA dehydrogenase FadE33;protein_id=CCP46386.1;transl_table=11
AL123456.3	EMBL	gene	4006200	4007366	.	+	.	ID=gene-Rv3565;Name=aspB;gbkey=Gene;gene=aspB;gene_biotype=protein_coding;locus_tag=Rv3565
AL123456.3	EMBL	CDS	4006200	4007366	.	+	0	ID=cds-CCP46387.1;Parent=gene-Rv3565;Dbxref=EnsemblGenomes-Gn:Rv3565,EnsemblGenomes-Tr:CCP46387,GOA:P96847,InterPro:IPR004838,InterPro:IPR004839,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,UniProtKB/TrEMBL:P96847,NCBI_GP:CCP46387.1;Name=CCP46387.1;Note=Rv3565%2C (MTCY06G11.12)%2C len: 388 aa. Possible aspB%2Caspartate aminotransferase%2C similar to many e.g. Q9A5J2|CC2455 aminotransferase class I from Caulobacter crescentus (381 aa)%2C FASTA scores: opt: 1112%2C E(): 1e-61%2C(45.85%25 identity in 384 aa overlap)%3B Q9HV76|PA4722 probable aminotransferase from Pseudomonas aeruginosa (390 aa)%2CFASTA scores: opt: 863%2C E(): 3.1e-46%2C (37.2%25 identity in 390 aa overlap)%3B Q9RWP3|DR0623 aspartate aminotransferase from Deinococcus radiodurans (388 aa)%2C FASTA scores: opt: 713%2C E(): 6.3e-37%2C (35.5%25 identity in 383 aa overlap)%3B Q9HQK2|ASPC2|VNG1121G aspartate aminotransferase from Halobacterium sp. strain NRC-1 (391 aa)%2C FASTA scores: opt: 710%2C E(): 9.8e-37%2C (34.45%25 identity in 380 aa overlap)%3B O33822|AAT_THEAQ|ASPC aspartate aminotransferase from Thermus aquaticus (383 aa)%2C FASTA scores: opt: 695%2C E(): 8.2e-36%2C (35.1%25 identity in 376 aa overlap)%3B etc. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. Belongs to class-I of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aspB;inference=protein motif:PROSITE:PS00105;locus_tag=Rv3565;product=Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase);protein_id=CCP46387.1;transl_table=11
AL123456.3	EMBL	gene	4007331	4008182	.	-	.	ID=gene-Rv3566c;Name=nat;gbkey=Gene;gene=nat;gene_biotype=protein_coding;gene_synonym=nhoA;locus_tag=Rv3566c
AL123456.3	EMBL	CDS	4007331	4008182	.	-	0	ID=cds-CCP46388.1;Parent=gene-Rv3566c;Dbxref=EnsemblGenomes-Gn:Rv3566c,EnsemblGenomes-Tr:CCP46388,GOA:P9WJI5,InterPro:IPR001447,NCBI_GP:CCP46388.1;Name=CCP46388.1;Note=Rv3566c%2C (MT3671%2C MTCY06G11.13c)%2C len: 283 aa. Nat (alternate gene name: nhoA)%2C arylamine N-acetyltransferase (see citations below)%2C highly similar to O86309|NAT_MYCSM arylamine N-acetyltransferase from Mycobacterium smegmatis (see citation below) (275 aa)%2C FASTA scores: opt: 1114%2CE(): 3e-66%2C (60.95%25 identity in 274 aa overlap). Also highly similar to others e.g. Q98D42|BAB51429|MLR4870 from Rhizobium loti (Mesorhizobium loti) (278 aa)%2C FASTA scores: opt: 697%2C E(): 1.1e-38%2C (44.1%25 identity in 272 aa overlap)%3B P77567|NHOA_ECOLI|B1463 from Escherichia coli strain K12 (281 aa)%2C FASTA scores: opt: 537%2C E(): 4.4e-28%2C (38.85%25 identity in 273 aa overlap)%3B Q00267|NHOA_SALTY from Salmonella typhimurium (281 aa)%2C FASTA scores: opt: 507%2CE(): 4.3e-26%2C (34.8%25 identity in 273 aa overlap)%3B etc. Belongs to the arylamine N-acetyltransferase family. Note that previously known as nhoA (332 aa) and that nucleotide 4007874 has been changed since first submission (G deleted).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nat;locus_tag=Rv3566c;product=Arylamine N-acetyltransferase Nat (arylamine acetylase);protein_id=CCP46388.1;transl_table=11
AL123456.3	EMBL	gene	4008167	4008433	.	-	.	ID=gene-Rv3566A;Name=Rv3566A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3566A
AL123456.3	EMBL	CDS	4008167	4008433	.	-	0	ID=cds-CCP46389.1;Parent=gene-Rv3566A;Dbxref=EnsemblGenomes-Gn:Rv3566A,EnsemblGenomes-Tr:CCP46389,UniProtKB/TrEMBL:I6YGI1,NCBI_GP:CCP46389.1;Name=CCP46389.1;Note=Rv3566A%2C len: 88 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3566A;product=Hypothetical protein;protein_id=CCP46389.1;transl_table=11
AL123456.3	EMBL	gene	4008719	4009282	.	-	.	ID=gene-Rv3567c;Name=hsaB;gbkey=Gene;gene=hsaB;gene_biotype=protein_coding;locus_tag=Rv3567c
AL123456.3	EMBL	CDS	4008719	4009282	.	-	0	ID=cds-CCP46390.1;Parent=gene-Rv3567c;Dbxref=EnsemblGenomes-Gn:Rv3567c,EnsemblGenomes-Tr:CCP46390,GOA:P9WND9,InterPro:IPR002563,InterPro:IPR012349,NCBI_GP:CCP46390.1;Name=CCP46390.1;Note=Rv3567c%2C (MTCY06G11.14c)%2C len: 187 aa. Possible hsaB%2C oxidoreductase%2C similar to various oxidoreductases and hypothetical proteins e.g. O69360 ORF61 protein from Rhodococcus erythropolis (194 aa) FASTA scores: opt: 974%2CE(): 3e-59%2C (77.05%25 identity in 183 aa overlap)%3B Q9JN75|MMYF putative oxidoreductase from Streptomyces coelicolor (174 aa)%2C FASTA scores: opt: 451%2C E(): 1e-23%2C(43.65%25 identity in 158 aa overlap)%3B P54990|NTAB_CHEHE|NMOB nitrilotriacetate monooxygenase component B from Chelatobacter heintzii (322 aa)%2C FASTA scores: opt: 409%2CE(): 1.3e-20%2C (38.3%25 identity in 167 aa overlap)Chelatobacter heintzii%3B AAK62356 putative NADH:FMN oxidoreductase from Burkholderia sp. DBT1 (177 aa)%2C FASTA scores: opt: 360%2C E(): 1.6e-17%2C (36.15%25 identity in 155 aa overlap).;gbkey=CDS;gene=hsaB;locus_tag=Rv3567c;product=Possible oxidoreductase. Possible 3-hydroxy-9%2C10-seconandrost-1%2C3%2C5(10)-triene-9%2C17-dione hydroxylase.;protein_id=CCP46390.1;transl_table=11
AL123456.3	EMBL	gene	4009297	4010199	.	-	.	ID=gene-Rv3568c;Name=hsaC;gbkey=Gene;gene=hsaC;gene_biotype=protein_coding;gene_synonym=bphC;locus_tag=Rv3568c
AL123456.3	EMBL	CDS	4009297	4010199	.	-	0	ID=cds-CCP46391.1;Parent=gene-Rv3568c;Dbxref=EnsemblGenomes-Gn:Rv3568c,EnsemblGenomes-Tr:CCP46391,GOA:P9WNW7,InterPro:IPR000486,InterPro:IPR004360,InterPro:IPR029068,PDB:2ZI8,PDB:2ZYQ,NCBI_GP:CCP46391.1;Name=CCP46391.1;Note=Rv3568c%2C (MTCY06G11.15c)%2C len: 300 aa. HsaC%2C highly similar to e.g. Q9KWQ5|BPHC5 from Rhodococcus sp. RHA1 (300 aa)%2C FASTA scores: opt: 1715%2C E(): 3.8e-103%2C (82.15%25 identity in 297 aa overlap)%3B O50479|EDOB from Rhodococcus rhodochrous (300 aa) FASTA scores: opt: 1714%2C E(): 4.4e-103%2C (82.5%25 identity in 297 aa overlap)%3B O69359|BPHC6 from Rhodococcus erythropolis (300 aa)%2C FASTA scores: opt: 1647%2C E(): 9.1e-99%2C (78.25%25 identity in 299 aa overlap)%3B Q9RBT2|BPHC1 from Pseudomonas sp. SY5 (301 aa) Pseudomonas sp. SY5 (298 aa) FASTA scores: opt: 767%2C E(): 3.9e-42%2C(42.8%25 identity in 299 aa overlap)%3B P47228|BPHC_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (297 aa)%2C FASTA scores: opt: 670%2C E(): 6.8e-36%2C (40.55%25 identity in 296 aa overlap)%3B etc. Contains PS00082 Extradiol ring-cleavage dioxygenases signature. Belongs to the extradiol ring-cleavage dioxygenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsaC;inference=protein motif:PROSITE:PS00082;locus_tag=Rv3568c;product=3%2C4-DHSA dioxygenase;protein_id=CCP46391.1;transl_table=11
AL123456.3	EMBL	gene	4010196	4011071	.	-	.	ID=gene-Rv3569c;Name=hsaD;gbkey=Gene;gene=hsaD;gene_biotype=protein_coding;gene_synonym=bphD;locus_tag=Rv3569c
AL123456.3	EMBL	CDS	4010196	4011071	.	-	0	ID=cds-CCP46392.1;Parent=gene-Rv3569c;Dbxref=EnsemblGenomes-Gn:Rv3569c,EnsemblGenomes-Tr:CCP46392,GOA:P9WNH5,InterPro:IPR000073,InterPro:IPR029058,PDB:2VF2,PDB:2WUD,PDB:2WUE,PDB:2WUF,PDB:2WUG,NCBI_GP:CCP46392.1;Name=CCP46392.1;Note=Rv3569c%2C (MTCY06G11.16c)%2C len: 291 aa. HsaD%2C highly similar to e.g. Q9KWQ6|BPHD2 from Rhodococcus sp. RHA1 (292 aa)%2C FASTA scores: opt: 1468%2C E(): 1.3e-85%2C (75.5%25 identity in 294 aa overlap)%3B Q52036 from Pseudomonas putida (286 aa)%2C FASTA scores: opt: 785%2C E(): 1.9e-42%2C (45.1%25 identity in 295 aa overlap)%3B Q52011|BPHD from Pseudomonas pseudoalcaligenes (286 aa)%2C FASTA scores: opt: 774%2C E(): 9.3e-42%2C (44.05%25 identity in 295 aa overlap)%3B P47229|BPHD_BURCE from Burkholderia cepacia (Pseudomonas cepacia) (286 aa) FASTA scores: opt: 772%2C E(): 1.2e-41%2C(44.5%25 identity in 295 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A. Similar to alpha/beta hydrolase fold.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsaD;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3569c;product=4%2C9-DHSA hydrolase;protein_id=CCP46392.1;transl_table=11
AL123456.3	EMBL	gene	4011086	4012270	.	-	.	ID=gene-Rv3570c;Name=hsaA;gbkey=Gene;gene=hsaA;gene_biotype=protein_coding;locus_tag=Rv3570c
AL123456.3	EMBL	CDS	4011086	4012270	.	-	0	ID=cds-CCP46393.1;Parent=gene-Rv3570c;Dbxref=EnsemblGenomes-Gn:Rv3570c,EnsemblGenomes-Tr:CCP46393,GOA:P9WJA1,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013107,InterPro:IPR013786,PDB:3AFE,PDB:3AFF,NCBI_GP:CCP46393.1;Name=CCP46393.1;Note=Rv3570c%2C (MTCY06G11.17c)%2C len: 394 aa. Possible hsaA%2C oxidoreductase%2C most similar to hydroxylases and oxygenases (and also some similarity to acyl-CoA dehydrogenases) e.g. O69349 hydroxylase from Rhodococcus erythropolis (393 aa)%2C FASTA scores: opt: 958%2C E(): 1.1e-53%2C (39.95%25 identity in 383 aa overlap)%3B P26698|PIGM_RHOSO pigment protein from Rhodococcus sp. strain ATCC 21145 (387 aa)%2C FASTA scores: opt: 665%2C E(): 5.4e-35%2C (32.2%25 identity in 382 aa overlap)%3B Q9ZGA9|LANZ5 oxygenase homolog from Streptomyces cyanogenus (397 aa) FASTA scores: opt: 588%2C E(): 4.5e-30%2C (30.55%25 identity in 386 aa overlap)%3B Q9F0J3|NCNH hydroxylase from Streptomyces arenae (405 aa)%2C FASTA scores: opt: 580%2C E(): 1.5e-29%2C(31.25%25 identity in 336 aa overlap)%3B O69789|BPFA indole dioxygenase from Rhodococcus opacus (399 aa)%2C FASTA scores: opt: 558%2C E(): 3.7e-28%2C (31.8%25 identity in 387 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hsaA;locus_tag=Rv3570c;product=Possible oxidoreductase. Possible 3-hydroxy-9%2C10-seconandrost-1%2C3%2C5(10)-triene-9%2C17-dione hydroxylase.;protein_id=CCP46393.1;transl_table=11
AL123456.3	EMBL	gene	4012417	4013493	.	+	.	ID=gene-Rv3571;Name=kshB;gbkey=Gene;gene=kshB;gene_biotype=protein_coding;gene_synonym=hmp;locus_tag=Rv3571
AL123456.3	EMBL	CDS	4012417	4013493	.	+	0	ID=cds-CCP46394.1;Parent=gene-Rv3571;Dbxref=EnsemblGenomes-Gn:Rv3571,EnsemblGenomes-Tr:CCP46394,GOA:P9WJ93,InterPro:IPR001041,InterPro:IPR001221,InterPro:IPR001433,InterPro:IPR001709,InterPro:IPR006058,InterPro:IPR008333,InterPro:IPR012675,InterPro:IPR017927,InterPro:IPR017938,NCBI_GP:CCP46394.1;Name=CCP46394.1;Note=Rv3571%2C (MTCY06G11.18)%2C len: 358 aa. kshB%2C reductase component of 3-ketosteroid-9-alpha-hydroxylase%2C similar to several e.g. Q44253|ATDA5 aniline dioxygenase reductase component from Acinetobacter sp (336 aa) FASTA scores: opt: 748%2C E(): 1.5e-38%2C (34.95%25 identity in 346 aa overlap)%3B P95533|TDNB electron transfer protein from Pseudomonas putida (337 aa)%2C FASTA scores: opt: 723%2C E(): 5.2e-37%2C(36.35%25 identity in 341 aa overlap)%3B AAK65059|SMA0752 possible dioxygenase reductase subunit from Rhizobium meliloti (Sinorhizobium meliloti) (353 aa) FASTA scores: opt: 495%2C E(): 4.9e-23%2C (31.9%25 identity in 345 aa overlap)%3B P76081|PAAE_ECOLI|B1392 probable phenylacetic acid degradation NADH oxidoreductase (356 aa)%2C FASTA scores: opt: 364%2C E(): 5.1e-15%2C (34.45%25 identity in 357 aa overlap)%3B Q9L131|HMPA flavohemoprotein from Streptomyces coelicolor (398 aa)%2C FASTA scores: opt: 352%2C E(): 3e-14%2C(32.8%25 identity in 247 aa overlap)%3B etc. Contains PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature. Note that it has been shown hmp transcription increased at early stationary phase and is lower at late stationary phase and during exponential growth. Note that previously known as hmp.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kshB;inference=protein motif:PROSITE:PS00197;locus_tag=Rv3571;product=Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB;protein_id=CCP46394.1;transl_table=11
AL123456.3	EMBL	gene	4013511	4014041	.	+	.	ID=gene-Rv3572;Name=Rv3572;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3572
AL123456.3	EMBL	CDS	4013511	4014041	.	+	0	ID=cds-CCP46395.1;Parent=gene-Rv3572;Dbxref=EnsemblGenomes-Gn:Rv3572,EnsemblGenomes-Tr:CCP46395,UniProtKB/TrEMBL:I6X7P2,NCBI_GP:CCP46395.1;Name=CCP46395.1;Note=Rv3572%2C (MTCY06G11.19)%2C len: 176 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3572;product=Unknown protein;protein_id=CCP46395.1;transl_table=11
AL123456.3	EMBL	gene	4014077	4016212	.	-	.	ID=gene-Rv3573c;Name=fadE34;gbkey=Gene;gene=fadE34;gene_biotype=protein_coding;locus_tag=Rv3573c
AL123456.3	EMBL	CDS	4014077	4016212	.	-	0	ID=cds-CCP46396.1;Parent=gene-Rv3573c;Dbxref=EnsemblGenomes-Gn:Rv3573c,EnsemblGenomes-Tr:CCP46396,GOA:P96855,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,InterPro:IPR013786,UniProtKB/TrEMBL:P96855,NCBI_GP:CCP46396.1;Name=CCP46396.1;Note=Rv3573c%2C (MTCY06G11.20c)%2C len: 711 aa. Probable fadE34%2C acyl-CoA dehydrogenase%2C similar to others%2Cespecially in C-terminal half%2C e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa) FASTA scores: opt: 780%2CE(): 2.8e-39%2C (44.1%25 identity in 347 aa overlap)%3B Q9A6N8|CC2049 from Caulobacter crescentus (401 aa)%2C FASTA scores: opt: 705%2C E(): 8.7e-35%2C (41.5%25 identity in 342 aa overlap)%3B Q9EX72|MLHC from Rhodococcus erythropolis (324 aa)%2C FASTA scores: opt: 673%2C E(): 6.1e-33%2C (42.05%25 identity in 283 aa overlap)%3B P41367|ACDM_PIG|ACADM from Sus scrofa (Pig)(421 aa) FASTA scores: opt: 325%2C E(): 4.9e- 13%2C (28.5%25 identity in 368 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. P95097|FADE22|Rv3061c|MTCY22D7.20 (721 aa)%2C FASTA scores: opt: 1635%2C E(): 2.7e-90%2C (42.65%25 identity in 729 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE34;inference=protein motif:PROSITE:PS01156;locus_tag=Rv3573c;product=Probable acyl-CoA dehydrogenase FadE34;protein_id=CCP46396.1;transl_table=11
AL123456.3	EMBL	gene	4016484	4017083	.	+	.	ID=gene-Rv3574;Name=kstR;gbkey=Gene;gene=kstR;gene_biotype=protein_coding;locus_tag=Rv3574
AL123456.3	EMBL	CDS	4016484	4017083	.	+	0	ID=cds-CCP46397.1;Parent=gene-Rv3574;Dbxref=EnsemblGenomes-Gn:Rv3574,EnsemblGenomes-Tr:CCP46397,GOA:P96856,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,PDB:3MNL,NCBI_GP:CCP46397.1;Name=CCP46397.1;Note=Rv3574%2C (MTCY06G11.21)%2C len: 199 aa. Probable kstR%2Ctranscriptional regulator TetR family%2C similar to others e.g. Q9KXK1|SCC53.10 from Streptomyces coelicolor (250 aa) FASTA scores: opt: 492%2C E(): 4.8e-25%2C (44.8%25 identity in 183 aa overlap)%3B Q9RA03|KSTR from Rhodococcus erythropolis (208 aa)%2C FASTA scores: opt: 294%2C E(): 3.1e-12%2C (28.9%25 identity in 187 aa overlap)%3B BAB54261|MLR7895 from Rhizobium loti (Mesorhizobium loti) (193 aa)%2C FASTA scores: opt: 166%2C E(): 0.00062%2C (32.05%25 identity in 78 aa overlap)%3B P17446|BETI_ECOLI|B0313 from Escherichia coli strain K12 (195 aa)%2C FASTA scores: opt: 142%2C E(): 0.0034%2C (25. 6%25 identity in 168 aa overlap)%3B etc. Equivalent to AAK48038 from Mycobacterium tuberculosis strain CDC1551 (243 aa) but shorter 44 aa. Contains possible helix-turn-helix motif from aa 37-58 (+3.70 SD). Possibly belongs to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=kstR;locus_tag=Rv3574;product=Transcriptional regulatory protein KstR (probably TetR-family);protein_id=CCP46397.1;transl_table=11
AL123456.3	EMBL	gene	4017089	4018168	.	-	.	ID=gene-Rv3575c;Name=Rv3575c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3575c
AL123456.3	EMBL	CDS	4017089	4018168	.	-	0	ID=cds-CCP46398.1;Parent=gene-Rv3575c;Dbxref=EnsemblGenomes-Gn:Rv3575c,EnsemblGenomes-Tr:CCP46398,GOA:P96857,InterPro:IPR000843,InterPro:IPR010982,InterPro:IPR028082,UniProtKB/TrEMBL:P96857,NCBI_GP:CCP46398.1;Name=CCP46398.1;Note=Rv3575c%2C (MTCY06G11.22c)%2C len: 359 aa. Probable transcriptional regulator belonging to lacI family%2C similar to others e.g. BAB53947|MLL8376 from Rhizobium loti (Mesorhizobium loti) (358 aa)%2C FASTA scores: opt: 707%2C E(): 2.6e-35%2C (35.5%25 identity in 355 aa overlap)%3B Q9RRI9|DR2501 from Deinococcus radiodurans (359 aa) FASTA scores: opt: 544%2C E(): 1.6e-25%2C (40.35%25 identity in 347 aa overlap)%3B Q9RL31|SCF51A.34 from Streptomyces coelicolor (347 aa)%2CFASTA scores: opt: 307%2C E(): 2.9e-11%2C (30.0%25 identity in 330 aa overlap)%3B O87590|CELR_THEFU from Thermomonospora fusca (340 aa)%2C FASTA scores: opt: 280%2C E(): 1.2e-09%2C(32.3%25 identity in 353 aa overlap)%3B P21867|RAFR_ECOLI from Escherichia coli (335 aa) FASTA scores: opt: 241%2C E(): 2.6e-07%2C (27.15%25 identity in 269 aa overlap)%3B etc. Equivalent to AAK48039 from Mycobacterium tuberculosis strain CDC1551 (404 aa) but shorter 45 aa. Contains possible helix-turn-helix motif%2C at aa 9-30 (+5.86 SD). Could belong to the LacI family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3575c;product=Transcriptional regulatory protein (probably LacI-family);protein_id=CCP46398.1;transl_table=11
AL123456.3	EMBL	gene	4018358	4019071	.	+	.	ID=gene-Rv3576;Name=lppH;gbkey=Gene;gene=lppH;gene_biotype=protein_coding;gene_synonym=pknM;locus_tag=Rv3576
AL123456.3	EMBL	CDS	4018358	4019071	.	+	0	ID=cds-CCP46399.1;Parent=gene-Rv3576;Dbxref=EnsemblGenomes-Gn:Rv3576,EnsemblGenomes-Tr:CCP46399,InterPro:IPR026954,UniProtKB/TrEMBL:I6YGJ4,NCBI_GP:CCP46399.1;Name=CCP46399.1;Note=Rv3576%2C (MTCY06G11.23)%2C len: 237 aa. Possible lppH%2Cconserved lipoprotein%2C similar in part with proteins from Mycobacterium tuberculosis%3B C-terminus of Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50.16 probable serine/threonine-protein kinase (626 aa) FASTA scores: opt: 396%2C E(): 6.5e-19%2C (36.0%25 identity in 200 aa overlap)%3B and with P71740|LPPR|Rv2403c|MTCY253.17 probable lipoprotein protein (251 aa)%2C FASTA scores: opt: 134%2C E(): 0.087%2C(22.7%25 identity in 207 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as pknM.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lppH;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3576;product=Possible conserved lipoprotein LppH;protein_id=CCP46399.1;transl_table=11
AL123456.3	EMBL	gene	4019262	4020128	.	+	.	ID=gene-Rv3577;Name=Rv3577;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3577
AL123456.3	EMBL	CDS	4019262	4020128	.	+	0	ID=cds-CCP46400.1;Parent=gene-Rv3577;Dbxref=EnsemblGenomes-Gn:Rv3577,EnsemblGenomes-Tr:CCP46400,GOA:P96859,InterPro:IPR001279,UniProtKB/TrEMBL:P96859,NCBI_GP:CCP46400.1;Name=CCP46400.1;Note=Rv3577%2C (MTCY06G11.24)%2C len: 288 aa (other start sites possible upstream%3B equivalent to AAK48041 from Mycobacterium tuberculosis strain CDC1551 (379 aa) but shorter 91 aa). Hypothetical protein%2C showing some similarity to Q9RI88|SCJ11.16c hypothetical 37.9 KDA protein from Streptomyces coelicolor (349 aa) FASTA scores: opt: 285%2C E(): 1.5e-10%2C (27.45%25 identity in 266 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3577;product=Conserved hypothetical protein;protein_id=CCP46400.1;transl_table=11
AL123456.3	EMBL	gene	4020142	4021383	.	+	.	ID=gene-Rv3578;Name=arsB2;gbkey=Gene;gene=arsB2;gene_biotype=protein_coding;locus_tag=Rv3578
AL123456.3	EMBL	CDS	4020142	4021383	.	+	0	ID=cds-CCP46401.1;Parent=gene-Rv3578;Dbxref=EnsemblGenomes-Gn:Rv3578,EnsemblGenomes-Tr:CCP46401,GOA:I6YCG9,InterPro:IPR000802,UniProtKB/TrEMBL:I6YCG9,NCBI_GP:CCP46401.1;Name=CCP46401.1;Note=Rv3578%2C (MTCY06G11.25)%2C len: 413 aa. Possible arsB2%2Carsenical pump integral membrane protein%2C similar to many e.g. Q9I1J6|ARSB|PA2278 from Pseudomonas aeruginosa (427 aa)%2C FASTA scores: opt: 375%2C E(): 3.1e-15%2C (32.15%25 identity in 429 aa overlap)%3B Q9K8K7|ARSB|BH2999 from Bacillus halodurans (436 aa)%2C FASTA scores: opt: 360%2C E(): 2.5e-14%2C(28.7%25 identity in 432 aa overlap)%3B P52146|ARB2_ECOLI from Escherichia coli (plasmid R46) (429 aa)%2C FASTA scores: opt: 345%2C E(): 2e-13%2C (29.8%25 identity in 426 aa overlap)%3B etc. Also highly similar to Q9KYM0|SC9H11.21c probable membrane efflux protein from Streptomyces coelicolor (446 aa)%2C FASTA scores: opt: 730%2C E(): 1.7e-36%2C (53.95%25 identity in 443 aa overlap). Seems to belong to the ARS family.;gbkey=CDS;gene=arsB2;locus_tag=Rv3578;product=Possible arsenical pump integral membrane protein ArsB2;protein_id=CCP46401.1;transl_table=11
AL123456.3	EMBL	gene	4021425	4022393	.	-	.	ID=gene-Rv3579c;Name=Rv3579c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3579c
AL123456.3	EMBL	CDS	4021425	4022393	.	-	0	ID=cds-CCP46402.1;Parent=gene-Rv3579c;Dbxref=EnsemblGenomes-Gn:Rv3579c,EnsemblGenomes-Tr:CCP46402,GOA:P9WFY5,InterPro:IPR001537,InterPro:IPR004441,InterPro:IPR013123,InterPro:IPR029026,InterPro:IPR029028,InterPro:IPR029064,NCBI_GP:CCP46402.1;Name=CCP46402.1;Note=Rv3579c%2C (MTCY06G11.26c)%2C len: 322 aa. Possible tRNA/rRNA methyltransferase%2C equivalent%2C but longer 31 aa%2Cto Q9CCW4|ML0324 putative methyltransferase from Mycobacterium leprae (278 aa)%2C FASTA scores: opt: 1517%2CE(): 3.4e-79%2C (83.75%25 identity in 277 aa overlap). Also highly similar to Q9L0Q5|SCD8A.09 from Streptomyces coelicolor (314 aa)%2C FASTA scores: opt: 937%2C E(): 3.4e-46%2C(56.75%25 identity in 319 aa overlap)%3B and similar to others e.g. Q06753|YACO_BACSU from Bacillus subtilis (249 aa)%2CFASTA scores: opt: 616%2C E(): 4.9e-28%2C (41.05%25 identity in 246 aa overlap)%3B Q9KGF2|BH0113 from Bacillus halodurans (249 aa)%2C FASTA scores: opt: 596%2C E(): 6.7e-27%2C (38.5%25 identity in 244 aa overlap)%3B P74328|Y955_SYNY3|SLR0955 from Synechocystis sp. strain PCC 6803 (384 aa)%2C FASTA scores: opt: 585%2C E(): 4e-26%2C (35.85%25 identity in 304 aa overlap)%3B P39290|YJFH_ECOLI|B4180 from Escherichia coli strain K12 (243 aa)%2C FASTA scores: opt: 521%2C E(): 1.2e-22%2C (38.1%25 identity in 244 aa overlap)%3B etc. Equivalent to AAK48043 from Mycobacterium tuberculosis strain CDC1551 (253 aa) but longer 69 aa. Possibly belongs to the RNA methyltransferase TrmH family.;gbkey=CDS;locus_tag=Rv3579c;product=Possible tRNA/rRNA methyltransferase;protein_id=CCP46402.1;transl_table=11
AL123456.3	EMBL	gene	4022394	4023803	.	-	.	ID=gene-Rv3580c;Name=cysS1;gbkey=Gene;gene=cysS1;gene_biotype=protein_coding;locus_tag=Rv3580c
AL123456.3	EMBL	CDS	4022394	4023803	.	-	0	ID=cds-CCP46403.1;Parent=gene-Rv3580c;Dbxref=EnsemblGenomes-Gn:Rv3580c,EnsemblGenomes-Tr:CCP46403,GOA:P9WFW1,InterPro:IPR009080,InterPro:IPR014729,InterPro:IPR015273,InterPro:IPR015803,InterPro:IPR024909,NCBI_GP:CCP46403.1;Name=CCP46403.1;Note=Rv3580c%2C (MTCY06G11.27c)%2C len: 469 aa. Probable cysS1%2C cysteinyl-tRNA synthetase%2C equivalent to P57990|SYC1_MYCLE|CYSS1|CYSS|ML0323 cysteinyl-tRNA synthetase 1 from Mycobacterium leprae (473 aa) FASTA scores: opt: 2825%2C E(): 3.4e-172%2C (86.5%25 identity in 467 aa overlap). Also similar to many e.g. Q9L0Q6|SCD8A.08 from Streptomyces coelicolor (613 aa)%2C FASTA scores: opt: 1834%2CE(): 4.7e-109%2C (57.5%25 identity in 461 aa overlap)%3B Q9I2U7|CYSS|PA1795 from Pseudomonas aeruginosa (460 aa) FASTA scores: opt: 1197%2C E(): 1.2e-68%2C (41.65%25 identity in 468 aa overlap)%3B P21888|SYC_ECOLI P21888|CYSS|B0526 from Escherichia coli strain K12 (461 aa)%2C FASTA scores: opt: 1189%2C E(): 4e-68%2C (43.0%25 identity in 463 aa overlap)%3B etc. Belongs to class-I aminoacyl-tRNA synthetase family. Strongly similar to methionyl-tRNA synthetase.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cysS1;locus_tag=Rv3580c;product=Cysteinyl-tRNA synthetase 1 CysS1 (cysteine--tRNA ligase 1) (CYSRS 1) (cysteine translase);protein_id=CCP46403.1;transl_table=11
AL123456.3	EMBL	gene	4023868	4024347	.	-	.	ID=gene-Rv3581c;Name=ispF;gbkey=Gene;gene=ispF;gene_biotype=protein_coding;locus_tag=Rv3581c
AL123456.3	EMBL	CDS	4023868	4024347	.	-	0	ID=cds-CCP46404.1;Parent=gene-Rv3581c;Dbxref=EnsemblGenomes-Gn:Rv3581c,EnsemblGenomes-Tr:CCP46404,GOA:P9WKG5,InterPro:IPR003526,InterPro:IPR020555,NCBI_GP:CCP46404.1;Name=CCP46404.1;Note=Rv3581c%2C (MT3687%2C MTCY06G11.28c)%2C len: 159 aa. Probable ispF%2C 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase%2C equivalent to Q9CCW5|ML0322 putative 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase from Mycobacterium leprae (158 aa)%2C FASTA scores: opt: 830%2C E(): 2.9e-47%2C (79.1%25 identity in 158 aa overlap). Also highly similar to others e.g. Q9L0Q7|ISPF_STRCO|SCD8A.07 from Streptomyces coelicolor (170 aa)%2C FASTA scores: opt: 585%2CE(): 2.9e-31%2C (56.5%25 identity in 154 aa overlap)%3B Q9PDT5|ISPF_XYLFA|XF1294 from Xylella fastidiosa (176 aa)%2CFASTA scores: opt: 398%2C E(): 4.6e-19%2C (44.9%25 identity in 156 aa overlap)%3B Q08113|ISDF_RHOCA|ISPDF from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (379 aa)%2C FASTA scores: opt: 387%2C E(): 4.5e-18%2C (42.85%25 identity in 154 aa overlap) (only similar with C-terminal end of this bifunctional protein ISPD and ISPF)%3B Q06756|ISPF_BACSU from Bacillus subtilis (158 aa)%2C FASTA scores: opt: 367%2C E(): 4.5e-17%2C (41.2%25 identity in 153 aa overlap)%3B etc. Belongs to the IspF family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ispF;locus_tag=Rv3581c;product=Probable 2C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase IspF (MECPS);protein_id=CCP46404.1;transl_table=11
AL123456.3	EMBL	gene	4024344	4025039	.	-	.	ID=gene-Rv3582c;Name=ispD;gbkey=Gene;gene=ispD;gene_biotype=protein_coding;locus_tag=Rv3582c
AL123456.3	EMBL	CDS	4024344	4025039	.	-	0	ID=cds-CCP46405.1;Parent=gene-Rv3582c;Dbxref=EnsemblGenomes-Gn:Rv3582c,EnsemblGenomes-Tr:CCP46405,GOA:P9WKG9,InterPro:IPR001228,InterPro:IPR018294,InterPro:IPR029044,PDB:2XWN,PDB:3OKR,PDB:3Q7U,PDB:3Q80,NCBI_GP:CCP46405.1;Name=CCP46405.1;Note=Rv3582c%2C (MT3688%2C MTCY06G11.29c)%2C len: 231 aa. ispD%2C4-diphosphocytidyl-2C-methyl-D-erythritol synthase %2Cequivalent to Q9CCW6|ML0321 putative 4-diphosphocytidyl-2C-methyl-D-erythritol synthase from Mycobacterium leprae (241 aa)%2C FASTA scores: opt: 694%2C E(): 1.7e-35%2C (66.95%25 identity in 236 aa overlap). Also highly similar to others e.g. Q9L0Q8|ISPD_STRCO|SCD8A.06 from Streptomyces coelicolor (270 aa)%2C FASTA scores: opt: 537%2CE(): 7.5e-26%2C (43.4%25 identity in 242 aa overlap)%3B P74323|ISPD_SYNY3|SLR0951 from Synechocystis sp. strain PCC 6803 (230 aa)%2C FASTA scores: opt: 410%2C E(): 3.8e-18%2C(36.15%25 identity in 224 aa overlap)%3B Q9KGF8|ISPD_BACHD|BH0107 from Bacillus halodurans (228 aa) FASTA scores: opt: 367%2C E(): 1.6e-15%2C (34.65%25 identity in 228 aa overlap)%3B Q08113|ISDF_RHOCA|ISPDF from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (379 aa)FASTA scores: opt: 359%2C E(): 7.8e-15%2C (34.1%25 identity in 223 aa overlap) (only similar with N-terminus of this bifunctional protein ISPD and ISPF)%3B Q46893|ISPD_ECOLI|B2747 from Escherichia coli strain K12 (235 aa)%2C FASTA scores: opt: 336%2C E(): 1.3e-13%2C (33.65%25 identity in 223 aa overlap)%3B etc. Belongs to the ISPD family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ispD;locus_tag=Rv3582c;product=4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (MEP cytidylyltransferase) (MCT);protein_id=CCP46405.1;transl_table=11
AL123456.3	EMBL	gene	4025056	4025544	.	-	.	ID=gene-Rv3583c;Name=Rv3583c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3583c
AL123456.3	EMBL	CDS	4025056	4025544	.	-	0	ID=cds-CCP46406.1;Parent=gene-Rv3583c;Dbxref=EnsemblGenomes-Gn:Rv3583c,EnsemblGenomes-Tr:CCP46406,GOA:P9WJG3,InterPro:IPR003711,PDB:4ILU,PDB:4KBM,PDB:4KMC,PDB:4MFR,NCBI_GP:CCP46406.1;Name=CCP46406.1;Note=Rv3583c%2C (MTV024.01c%2C MTCY06G11.30c)%2C len: 162 aa. Possible transcriptional factor%2C identical to Q9CCW7|ML0320 putative transcription factor from Mycobacterium leprae (165 aa)%2C FASTA scores: opt: 1004%2C E(): 6.1e-56%2C (97.55%25 identity in 162 aa overlap)%3B and Q9ZBM8|MLCB1450.01c putative transcriptional regulator from Mycobacterium leprae (94 aa)%2C FASTA scores: opt: 600%2C E(): 6e-31%2C (97.85%25 identity in 94 aa overlap). Also highly similar to others e.g. Q9L0Q9|SCD8A.05 from Streptomyces coelicolor (160 aa)%2CFASTA scores: opt: 878%2C E(): 4.3e-48%2C (85.0%25 identity in 160 aa overlap)%3B Q9K600|BH3935 from Bacillus halodurans (153 aa) FASTA scores: opt: 383%2C E(): 3.1e-17%2C (36.4%25 identity in 151 aa overlap)%3B Q9KD36|BH1383 from Bacillus halodurans (164 aa) FASTA scores: opt: 305%2C E(): 2.4e-12%2C(33.55%25 identity in 164 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3583c;product=Possible transcription factor;protein_id=CCP46406.1;transl_table=11
AL123456.3	EMBL	gene	4025830	4026378	.	+	.	ID=gene-Rv3584;Name=lpqE;gbkey=Gene;gene=lpqE;gene_biotype=protein_coding;locus_tag=Rv3584
AL123456.3	EMBL	CDS	4025830	4026378	.	+	0	ID=cds-CCP46407.1;Parent=gene-Rv3584;Dbxref=EnsemblGenomes-Gn:Rv3584,EnsemblGenomes-Tr:CCP46407,GOA:P9WK63,NCBI_GP:CCP46407.1;Name=CCP46407.1;Note=Rv3584%2C (MTV024.02)%2C len: 182 aa. Possible lpqE%2Cconserved lipoprotein%2C equivalent to Q9ZBM7|MLCB1450.02|LPQE|ML0319 putative lipoprotein from Mycobacterium leprae (183 aa)%2C FASTA scores: opt: 722%2C E(): 6.2e-37%2C (63.45%25 identity in 175 aa overlap). Also similar in part to Q9KK69 exported protein 996A010 (fragment) from Mycobacterium avium (41 aa)%2C FASTA scores: opt: 180%2C E(): 0.00012%2C (69.25%25 identity in 39 aa overlap)%3B and Q9L0R0|SCD8A.04c putative lipoprotein from Streptomyces coelicolor (241 aa)%2C FASTA scores: opt: 127%2C E(): 0.86%2C(27.15%25 identity in 173 aa overlap). Equivalent to AAK48048 from Mycobacterium tuberculosis strain CDC1551 (238 aa) but shorter 56 aa. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqE;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3584;product=Possible conserved lipoprotein LpqE;protein_id=CCP46407.1;transl_table=11
AL123456.3	EMBL	gene	4026444	4027886	.	+	.	ID=gene-Rv3585;Name=radA;gbkey=Gene;gene=radA;gene_biotype=protein_coding;locus_tag=Rv3585
AL123456.3	EMBL	CDS	4026444	4027886	.	+	0	ID=cds-CCP46408.1;Parent=gene-Rv3585;Dbxref=EnsemblGenomes-Gn:Rv3585,EnsemblGenomes-Tr:CCP46408,GOA:P9WHJ9,InterPro:IPR003593,InterPro:IPR004504,InterPro:IPR014721,InterPro:IPR020568,InterPro:IPR020588,InterPro:IPR027417,NCBI_GP:CCP46408.1;Name=CCP46408.1;Note=Rv3585%2C (MTV024.03)%2C len: 480 aa. Probable radA%2C DNA repair protein (see citation below)%2C similar to many e.g. Q9X8L5|SCE94.02 from Streptomyces coelicolor (469 aa)%2CFASTA scores: opt: 1607%2C E(): 3.1e-84%2C (56.15%25 identity in 454 aa overlap)%3B Q9JV51|RADA|NMA0992 from Neisseria meningitidis (serogroup A) (459 aa)%2C FASTA scores: opt: 1275%2C E(): 2.5e-65%2C (45.0%25 identity in 458 aa overlap)%3B and Q9K040|RADA|NMB0782 from Neisseria meningitidis (serogroup B) (459 aa)%2C FASTA scores: opt: 1269%2C E(): 5.4e-65%2C (44.5%25 identity in 456 aa overlap)%3B P37572|RADA_BACSU|SMS from Bacillus subtilis (458 aa)%2C FASTA scores: opt: 1204%2C E(): 2.7e-61%2C (39.55%25 identity in 455 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the RadA family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=radA;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3585;product=DNA repair protein RadA (DNA repair protein SMS);protein_id=CCP46408.1;transl_table=11
AL123456.3	EMBL	gene	4027891	4028967	.	+	.	ID=gene-Rv3586;Name=Rv3586;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3586
AL123456.3	EMBL	CDS	4027891	4028967	.	+	0	ID=cds-CCP46409.1;Parent=gene-Rv3586;Dbxref=EnsemblGenomes-Gn:Rv3586,EnsemblGenomes-Tr:CCP46409,GOA:P9WNW5,InterPro:IPR003390,InterPro:IPR010994,InterPro:IPR018906,InterPro:IPR023763,NCBI_GP:CCP46409.1;Name=CCP46409.1;Note=Rv3586%2C (MTV024.04)%2C len: 358 aa. Conserved hypothetical protein%2C highly similar to Q9X8L6|SCE94.03 putative DNA-binding protein from Streptomyces coelicolor (374 aa)%2C FASTA scores: opt: 1338%2C E(): 5e-75%2C (59.95%25 identity in 347 aa overlap)%3B P37573|YACK_BACSU hypothetical 40.7 KDA protein from Bacillus subtilis (360 aa)%2C FASTA scores: opt: 875%2C E(): 1.4e-46%2C (42.15%25 identity in 344 aa overlap)%3B Q9KGG0|BH0105 hypothetical protein from Bacillus halodurans (357 aa)%2C FASTA scores: opt: 844%2C E(): 1.1e-44%2C(40.3%25 identity in 350 aa overlap)%3B Q9WY43|TM0200 conserved hypothetical protein from Thermotoga maritima (357 aa)%2CFASTA scores: opt: 735%2C E(): 5.7e-38%2C (39.4%25 identity in 353 aa overlap). Also some similarity with other proteins. Contains probable coiled-coil from 144 to 179.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3586;product=Conserved hypothetical protein;protein_id=CCP46409.1;transl_table=11
AL123456.3	EMBL	gene	4028968	4029762	.	-	.	ID=gene-Rv3587c;Name=Rv3587c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3587c
AL123456.3	EMBL	CDS	4028968	4029762	.	-	0	ID=cds-CCP46410.1;Parent=gene-Rv3587c;Dbxref=EnsemblGenomes-Gn:Rv3587c,EnsemblGenomes-Tr:CCP46410,GOA:O53572,UniProtKB/TrEMBL:O53572,NCBI_GP:CCP46410.1;Name=CCP46410.1;Note=Rv3587c%2C (MTV024.05c)%2C len: 264 aa. Probable conserved membrane protein%2C equivalent to Q9CBJ2|ML1918 hypothetical membrane protein from Mycobacterium leprae (263 aa)%2C FASTA scores: opt: 1438%2C E(): 2.4e-57%2C (77.55%25 identity in 267 aa overlap). Contains hydrophobic stretch in N-terminus%3B possible signal sequence. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3587c;product=Probable conserved membrane protein;protein_id=CCP46410.1;transl_table=11
AL123456.3	EMBL	gene	4029871	4030494	.	-	.	ID=gene-Rv3588c;Name=canB;gbkey=Gene;gene=canB;gene_biotype=protein_coding;locus_tag=Rv3588c
AL123456.3	EMBL	CDS	4029871	4030494	.	-	0	ID=cds-CCP46411.1;Parent=gene-Rv3588c;Dbxref=EnsemblGenomes-Gn:Rv3588c,EnsemblGenomes-Tr:CCP46411,GOA:P9WPJ9,InterPro:IPR001765,InterPro:IPR015892,PDB:1YM3,PDB:2A5V,NCBI_GP:CCP46411.1;Name=CCP46411.1;Note=Rv3588c%2C (MTV024.06c)%2C len: 207 aa. CanB%2CBeta-carbonic anhydrase%2C proven biochemically (See Suarez Covarrubias et al. 2005) similar to others e.g. Q9CBJ1|ML1919 putative carbonic anhydrase from Mycobacterium leprae (213 aa)%2C FASTA scores: opt: 1160%2CE(): 3.1e-66%2C (84.55%25 identity in 207 aa overlap). Also similar to many e.g. Q9X903|SCH35.03 from Streptomyces coelicolor (207 aa)%2C FASTA scores: opt: 689%2C E(): 1.6e-36%2C(53.85%25 identity in 195 aa overlap)%3B Q9RS89|DR2238 from Deinococcus radiodurans (264 aa)%2C FASTA scores: opt: 451%2CE(): 2e-21%2C (39.7%25 identity in 189 aa overlap)%3B Q39589|beta-CA1 from Chlamydomonas reinhardtii (267 aa) FASTA scores: opt: 419%2C E(): 2.1e-19%2C (36.55%25 identity in 197 aa overlap)%3B etc. Contains PS00704 and PS00705 Prokaryotic-type carbonic anhydrases signature 1 and 2. Belongs to the plant and prokaryotic carbonic anhydrase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=canB;inference=protein motif:PROSITE:PS00705;locus_tag=Rv3588c;product=Beta-carbonic anhydrase CanB;protein_id=CCP46411.1;transl_table=11
AL123456.3	EMBL	gene	4030493	4031407	.	+	.	ID=gene-Rv3589;Name=mutY;gbkey=Gene;gene=mutY;gene_biotype=protein_coding;locus_tag=Rv3589
AL123456.3	EMBL	CDS	4030493	4031407	.	+	0	ID=cds-CCP46412.1;Parent=gene-Rv3589;Dbxref=EnsemblGenomes-Gn:Rv3589,EnsemblGenomes-Tr:CCP46412,GOA:P9WQ09,InterPro:IPR000445,InterPro:IPR003265,InterPro:IPR003651,InterPro:IPR011257,InterPro:IPR023170,NCBI_GP:CCP46412.1;Name=CCP46412.1;Note=Rv3589%2C (MTV024.07)%2C len: 304 aa. Probable mutY%2Cadenine glycosylase (see citation below)%2C equivalent to Q9CBJ0|MUTY|ML1920 probable DNA glycosylase from Mycobacterium leprae (297 aa)%2C FASTA scores: opt: 1592%2CE(): 2.6e-94%2C (74.9%25 identity in 303 aa overlap). Also similar to many DNA glycosylases (generally adenine glycosylases) e.g. Q9S6T7|SCE94.06 from Streptomyces coelicolor (308 aa)%2C FASTA scores: opt: 965%2C E(): 2.6e-54%2C(50.5%25 identity in 297 aa overlap)%3B Q9S6G1|MUTY from Streptomyces antibioticus (307 aa)%2C FASTA scores: opt: 901%2CE(): 3.1e-50%2C (48.5%25 identity in 303 aa overlap)%3B Q9HPQ6|MUTY|VNG1520G from Halobacterium sp. strain NRC-1 (312 aa)%2C FASTA scores: opt: 566%2C E(): 7.2e-29%2C (39.85%25 identity in 296 aa overlap)%3B BAB53965|MLL7523 from Rhizobium loti (Mesorhizobium loti) (396 aa)%2C FASTA scores: opt: 511%2C E(): 2.8e-25%2C (39.65%25 identity in 237 aa overlap)%3B Q05869|MUTY_SALTY|MUTB from Salmonella typhimurium (350 aa)%2C FASTA scores: opt: 421%2C E(): 3.8e-20%2C(35.2%25 identity in 227 aa overlap)%3B etc. Could belong to the nth/MUTY family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mutY;locus_tag=Rv3589;product=Probable adenine glycosylase MutY;protein_id=CCP46412.1;transl_table=11
AL123456.3	EMBL	gene	4031404	4033158	.	-	.	ID=gene-Rv3590c;Name=PE_PGRS58;gbkey=Gene;gene=PE_PGRS58;gene_biotype=protein_coding;locus_tag=Rv3590c
AL123456.3	EMBL	CDS	4031404	4033158	.	-	0	ID=cds-CCP46413.1;Parent=gene-Rv3590c;Dbxref=EnsemblGenomes-Gn:Rv3590c,EnsemblGenomes-Tr:CCP46413,InterPro:IPR000084,UniProtKB/TrEMBL:I6XHM5,NCBI_GP:CCP46413.1;Name=CCP46413.1;Note=Rv3590c%2C (MTV024.08c%2C MTCY6F7.04)%2C len: 584 aa. PE_PGRS58%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2C highly similar to e.g. O53439|Rv1091|MTV017.44 (853 aa)%2C FASTA scores: opt: 2005%2C E(): 1.4e-70%2C (54.95%25 identity in 646 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS58;locus_tag=Rv3590c;product=PE-PGRS family protein PE_PGRS58;protein_id=CCP46413.1;transl_table=11
AL123456.3	EMBL	gene	4033269	4034042	.	-	.	ID=gene-Rv3591c;Name=Rv3591c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3591c
AL123456.3	EMBL	CDS	4033269	4034042	.	-	0	ID=cds-CCP46414.1;Parent=gene-Rv3591c;Dbxref=EnsemblGenomes-Gn:Rv3591c,EnsemblGenomes-Tr:CCP46414,GOA:I6YGL1,InterPro:IPR029058,UniProtKB/TrEMBL:I6YGL1,NCBI_GP:CCP46414.1;Name=CCP46414.1;Note=Rv3591c%2C (MTCY6F7.03)%2C len: 257 aa. Possible hydrolase%2C equivalent to Q9CBI9|ML1921 hypothetical protein from Mycobacterium leprae (256 aa) FASTA scores: opt: 1421%2CE(): 5.6e-83%2C (78.5%25 identity in 251 aa overlap). Also similar to others e.g. Q9K3V0|SCD10.27 putative hydrolase from Streptomyces coelicolor (352 aa)%2C FASTA scores: opt: 193%2C E(): 5.2e-05%2C (33.35%25 identity in 270 aa overlap)%3B O33745|STTC thioesterase from Streptomyces sp (308 aa) FASTA scores: opt: 242%2C E(): 3.6e-08%2C (30.35%25 identity in 270 aa overlap)%3B Q9RK95|SCF1.09 putative hydrolase from Streptomyces coelicolor (258 aa)%2C FASTA scores: opt: 239%2CE(): 4.9e-08%2C (30.75%25 identity in 247 aa overlap)%3B Q9HZ14|PA3226 probable hydrolase from Pseudomonas aeruginosa (275 aa)%2C FASTA scores: opt: 226%2C E(): 3.4e-07%2C(26.6%25 identity in 252 aa overlap)%3B Q9HPT9|est|VNG1474G carboxylesterase from Halobacterium sp. strain NRC-1 (274 aa)%2C FASTA scores: opt: 215%2C E(): 1.7e-06%2C (26.95%25 identity in 256 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3591c;product=Possible hydrolase;protein_id=CCP46414.1;transl_table=11
AL123456.3	EMBL	gene	4034057	4034374	.	+	.	ID=gene-Rv3592;Name=mhuD;gbkey=Gene;gene=mhuD;gene_biotype=protein_coding;gene_synonym=TB11.2;locus_tag=Rv3592
AL123456.3	EMBL	CDS	4034057	4034374	.	+	0	ID=cds-CCP46415.1;Parent=gene-Rv3592;Dbxref=EnsemblGenomes-Gn:Rv3592,EnsemblGenomes-Tr:CCP46415,GOA:P9WKH3,InterPro:IPR007138,InterPro:IPR011008,PDB:3HX9,PDB:4NL5,NCBI_GP:CCP46415.1;Name=CCP46415.1;Note=Rv3592%2C (MTCY6F7.02c)%2C len: 105 aa. Possible mhuD%2Cheme-degrading protein%2C equivalent to Q9CBI8|ML1922 hypothetical protein from Mycobacterium leprae (105 aa) FASTA scores: opt: 591%2C E(): 2.5e-34%2C (84.6%25 identity in 104 aa overlap). Shows some similarity with other bacterial hypothetical proteins e.g. Q9RXN8|DR0272 from Deinococcus radiodurans (109 aa)%2C FASTA scores: opt: 178%2C E(): 1e-05%2C(34.3%25 identity in 102 aa overlap)%3B P38049|YHGC_BACSU from Bacillus subtilis (166 aa) FASTA scores: opt: 175%2C E(): 2.4e-05%2C (40.85%25 identity in 71 aa overlap)%3B Q9K649|BH3883 from Bacillus halodurans (102 aa) FASTA scores: opt: 162%2CE(): 0.00012%2C (33.75%25 identity in 80 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mhuD;locus_tag=Rv3592;product=Possible heme degrading protein MhuD;protein_id=CCP46415.1;transl_table=11
AL123456.3	EMBL	gene	4034352	4035710	.	+	.	ID=gene-Rv3593;Name=lpqF;gbkey=Gene;gene=lpqF;gene_biotype=protein_coding;locus_tag=Rv3593
AL123456.3	EMBL	CDS	4034352	4035710	.	+	0	ID=cds-CCP46416.1;Parent=gene-Rv3593;Dbxref=EnsemblGenomes-Gn:Rv3593,EnsemblGenomes-Tr:CCP46416,GOA:O06155,InterPro:IPR012338,UniProtKB/TrEMBL:O06155,NCBI_GP:CCP46416.1;Name=CCP46416.1;Note=Rv3593%2C (MTCY6F7.01c)%2C len: 452 aa. Probable lpqF%2Cconserved lipoprotein%2C equivalent to Q9CBI7|MPQF|ML1923 probale secreted protein from Mycobacterium leprae (454 aa)%2C FASTA scores: opt: 2465%2C E(): 5.7e-144%2C (79.15%25 identity in 451 aa overlap). Also similar to Q9KJ91 hypothetical 47.1 KDA protein from Streptomyces clavuligerus (430 aa)%2C FASTA scores: opt: 609%2C E(): 5.2e-30%2C (30.3%25 identity in 350 aa overlap)%3B and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 beta lactamase-related protein from Deinococcus radiodurans (499 aa)%2C FASTA scores: opt: 322%2CE(): 2.5e-12%2C (28.25%25 identity in 322 aa overlap). Equivalent to AAK48057 from Mycobacterium tuberculosis strain CDC1551 (438 aa) but longer 14 aa. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;gbkey=CDS;gene=lpqF;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3593;product=Probable conserved lipoprotein LpqF;protein_id=CCP46416.1;transl_table=11
AL123456.3	EMBL	gene	4035857	4036684	.	+	.	ID=gene-Rv3594;Name=Rv3594;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3594
AL123456.3	EMBL	CDS	4035857	4036684	.	+	0	ID=cds-CCP46417.1;Parent=gene-Rv3594;Dbxref=EnsemblGenomes-Gn:Rv3594,EnsemblGenomes-Tr:CCP46417,GOA:I6Y3Z2,InterPro:IPR002502,UniProtKB/TrEMBL:I6Y3Z2,NCBI_GP:CCP46417.1;Name=CCP46417.1;Note=Rv3594%2C (MTCY07H7B.28c)%2C len: 275 aa. Hypothetical protein%2C highly similar in part with Q9ZX49|GP29 from Mycobacteriophage TM4 (547 aa)%2C FASTA scores: opt: 526%2CE(): 1.3e-25%2C (46.25%25 identity in 186 aa overlap)%3B and Q9FZS0|LYSA|GP2 from Mycobacterium phage Ms6 (384 aa) FASTA scores: opt: 147%2C E(): 0.064%2C (33.35%25 identity in 84 aa overlap).;gbkey=CDS;locus_tag=Rv3594;product=Conserved hypothetical protein;protein_id=CCP46417.1;transl_table=11
AL123456.3	EMBL	gene	4036731	4038050	.	-	.	ID=gene-Rv3595c;Name=PE_PGRS59;gbkey=Gene;gene=PE_PGRS59;gene_biotype=protein_coding;locus_tag=Rv3595c
AL123456.3	EMBL	CDS	4036731	4038050	.	-	0	ID=cds-CCP46418.1;Parent=gene-Rv3595c;Dbxref=EnsemblGenomes-Gn:Rv3595c,EnsemblGenomes-Tr:CCP46418,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MWV6,NCBI_GP:CCP46418.1;Name=CCP46418.1;Note=Rv3595c%2C (MTCY07H7B.27)%2C len: 439 aa. PE_PGRS59%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citation below)%2Csimilar to many e.g. O53439|Rv1091|MTV017.44 (853 aa)%2CFASTA scores: opt: 1644%2C E(): 1.2e-57%2C (58.75%25 identity in 492 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS59;locus_tag=Rv3595c;product=PE-PGRS family protein PE_PGRS59;protein_id=CCP46418.1;transl_table=11
AL123456.3	EMBL	gene	4038158	4040704	.	-	.	ID=gene-Rv3596c;Name=clpC1;gbkey=Gene;gene=clpC1;gene_biotype=protein_coding;gene_synonym=clpC;locus_tag=Rv3596c
AL123456.3	EMBL	CDS	4038158	4040704	.	-	0	ID=cds-CCP46419.1;Parent=gene-Rv3596c;Dbxref=EnsemblGenomes-Gn:Rv3596c,EnsemblGenomes-Tr:CCP46419,GOA:P9WPC9,InterPro:IPR001270,InterPro:IPR001943,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR004176,InterPro:IPR018368,InterPro:IPR019489,InterPro:IPR023150,InterPro:IPR027417,PDB:3WDB,PDB:3WDC,PDB:3WDD,PDB:3WDE,NCBI_GP:CCP46419.1;Name=CCP46419.1;Note=Rv3596c%2C (MTCY07H7B.26)%2C len: 848 aa. Probable clpC1%2C ATP-dependent protease ATP-binding subunit%2Cequivalent to P24428|CLPC_MYCLE probable ATP-dependent CLP protease ATP-binding subunit from Mycobacterium leprae (848 aa) (see Misra et al.%2C 1996)%2C FASTA scores: opt: 5286%2C E(): 0%2C (97.15%25 identity in 845 aa overlap). Also highly similar to members of the clpA/clpB family e.g. Q9S6T8|SCE94.24c from Streptomyces coelicolor (841 aa) FASTA scores: opt: 4399%2C E(): 0%2C (81.0%25 identity in 848 aa overlap)%3B Q9KGG2|CLPC|BH0103 from Bacillus halodurans (813 aa)%2C FASTA scores: opt: 3279%2C E(): 3.8e-173%2C (61.9%25 identity in 808 aa overlap)%3B Q55662|CLPC|SLL0020 from Synechocystis sp. strain PCC 6803 (821 aa)%2C FASTA scores: opt: 3201%2C E(): 7.6e-169%2C(60.5%25 identity in 820 aa overlap)%3B P51332|CLPC_PORPU from Porphyra purpurea (821 aa)%2C FASTA scores: opt: 3045%2C E(): 3e-160%2C (57.65%25 identity in 817 aa overlap)%3B P37571|CLPC_BACSU|MECB from Bacillus subtilis (810 aa)%2CFASTA scores: opt: 2969%2C E(): 4.6e-156%2C (61.15%25 identity in 811 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Note that previously known as clpC. Belongs to the CLPA/CLPB family%2C CLPC subfamily. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=clpC1;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3596c;product=Probable ATP-dependent protease ATP-binding subunit ClpC1;protein_id=CCP46419.1;transl_table=11
AL123456.3	EMBL	gene	4040879	4040938	.	+	.	ID=gene-mpr17;Name=mpr17;gbkey=Gene;gene=mpr17;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	4040879	4040938	.	+	.	ID=rna-mpr17;Parent=gene-mpr17;Note=mpr17%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C 82-118 nt bands detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr17;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	4040879	4040938	.	+	.	ID=exon-mpr17-1;Parent=rna-mpr17;Note=mpr17%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C 82-118 nt bands detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr17;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	4040981	4041319	.	-	.	ID=gene-Rv3597c;Name=lsr2;gbkey=Gene;gene=lsr2;gene_biotype=protein_coding;locus_tag=Rv3597c
AL123456.3	EMBL	CDS	4040981	4041319	.	-	0	ID=cds-CCP46420.1;Parent=gene-Rv3597c;Dbxref=EnsemblGenomes-Gn:Rv3597c,EnsemblGenomes-Tr:CCP46420,GOA:P9WIP7,InterPro:IPR024412,PDB:2KNG,PDB:4E1P,PDB:4E1R,NCBI_GP:CCP46420.1;Name=CCP46420.1;Note=Rv3597c%2C (MTCY07H7B.25)%2C len: 112 aa. Lsr2%2CH-NS-like protein%2C identical to P24094|LSR2_MYCLE|ML0234 LSR2 protein precursor (15 KDA antigen) (A15) from Mycobacterium leprae (112 aa)%2C FASTA scores: opt: 698%2C E(): 6.7e-37%2C (92.85%25 identity in 112 aa overlap). Also highly similar to others e.g. Q9X8N1|SCE94.26c from Streptomyces coelicolor (111 aa)%2C FASTA scores: opt: 379%2C E(): 4.4e-17%2C(58.05%25 identity in 112 aa overlap)%3B Q9ETI2|LSR2 from Corynebacterium equii (Rhodococcus equi) (119 aa)%2C FASTA scores: opt: 328%2C E(): 6.9e-14%2C (47.5%25 identity in 120 aa overlap)%3B and Q9RKK8|SCD25.12c from Streptomyces coelicolor (105 aa)%2C FASTA scores: opt: 293%2C E(): 9.4e-12%2C (47.75%25 identity in 111 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lsr2;locus_tag=Rv3597c;product=Iron-regulated H-NS-like protein Lsr2;protein_id=CCP46420.1;transl_table=11
AL123456.3	EMBL	gene	4041423	4042940	.	-	.	ID=gene-Rv3598c;Name=lysS;gbkey=Gene;gene=lysS;gene_biotype=protein_coding;locus_tag=Rv3598c
AL123456.3	EMBL	CDS	4041423	4042940	.	-	0	ID=cds-CCP46421.1;Parent=gene-Rv3598c;Dbxref=EnsemblGenomes-Gn:Rv3598c,EnsemblGenomes-Tr:CCP46421,GOA:P9WFU9,InterPro:IPR002313,InterPro:IPR004364,InterPro:IPR004365,InterPro:IPR006195,InterPro:IPR012340,InterPro:IPR018149,InterPro:IPR018150,NCBI_GP:CCP46421.1;Name=CCP46421.1;Note=Rv3598c%2C (MTCY07H7B.24)%2C len: 505 aa. Probable lysS%2Clysyl-tRNA synthetase 1%2C equivalent to P46861|SYK_MYCLE|LYSS|ML0233 lysyl-tRNA synthetase from Mycobacterium leprae (507 aa)%2C FASTA scores: opt: 2835%2CE(): 4.5e-172%2C (85.45%25 identity in 501 aa overlap)%3B and similar with C-terminal part of Q9CC23|LYSX|ML1393 C-term lysyl-tRNA synthase from Mycobacterium leprae (1039 aa) FASTA scores: opt: 1257%2C E(): 7.6e-72%2C (44.55%25 identity in 505 aa overlap). Also similar to others e.g. P37477|SYK_BACSU|LYSS from Bacillus subtilis (499 aa) FASTA scores: opt: 1294%2C E(): 1.9e-74%2C (42.35%25 identity in 498 aa overlap)%3B Q9RHV9|SYK_BACST|LYSS from Bacillus stearothermophilus (494 aa)%2C FASTA scores: opt: 1258%2C E(): 3.5e-72%2C (41.15%25 identity in 498 aa overlap)%3B Q9PEB6|SYK_XYLFA|LYSS|XF1112 from Xylella fastidiosa (506 aa)%2C FASTA scores: opt: 1228%2C E(): 2.9e-70%2C (43.05%25 identity in 495 aa overlap)%3B etc. Also similar to P94974|SYK2_MYCTU|LYSS2|LYSX|Rv1640c|MTCY06H11.04c lysyl-tRNA synthetase 2 from Mycobacterium tuberculosis (1172 aa)%2C FASTA scores: opt: 1295%2C E(): 3.3e-74%2C (45.65%25 identity in 506 aa overlap). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lysS;inference=protein motif:PROSITE:PS00179;locus_tag=Rv3598c;product=Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase);protein_id=CCP46421.1;transl_table=11
AL123456.3	EMBL	gene	4042952	4043035	.	-	.	ID=gene-Rv3599c;Name=Rv3599c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3599c
AL123456.3	EMBL	CDS	4042952	4043035	.	-	0	ID=cds-CCP46422.1;Parent=gene-Rv3599c;Dbxref=EnsemblGenomes-Gn:Rv3599c,EnsemblGenomes-Tr:CCP46422,UniProtKB/TrEMBL:O06283,NCBI_GP:CCP46422.1;Name=CCP46422.1;Note=Rv3599c%2C (MTCY07H7B.23)%2C len: 27 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3599c;product=Hypothetical short protein;protein_id=CCP46422.1;transl_table=11
AL123456.3	EMBL	gene	4043041	4043859	.	-	.	ID=gene-Rv3600c;Name=Rv3600c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3600c
AL123456.3	EMBL	CDS	4043041	4043859	.	-	0	ID=cds-CCP46423.1;Parent=gene-Rv3600c;Dbxref=EnsemblGenomes-Gn:Rv3600c,EnsemblGenomes-Tr:CCP46423,GOA:P9WPA1,InterPro:IPR004619,NCBI_GP:CCP46423.1;Name=CCP46423.1;Note=Rv3600c%2C (MTCY07H7B.22)%2C len: 272 aa. Conserved protein%2C identical to Q9CD56|ML0232 hypothetical protein from Mycobacterium leprae (274 aa)%2C FASTA scores: opt: 1585%2C E(): 1.3e-92%2C (90.5%25 identity in 274 aa overlap). Also highly similar to others e.g. Q9X8N6|SCE94.31c from Streptomyces coelicolor (265 aa) FASTA scores: opt: 878%2CE(): 3.9e-48%2C (51.5%25 identity in 268 aa overlap)%3B and Q9KGH5|BH0086 from Bacillus halodurans (254 aa)%2C FASTA scores: opt: 611%2C E(): 2.4e-31%2C (37.5%25 identity in 264 aa overlap). And similar to various bacterial proteins e.g. Q9F985 putative 32 KDA replication protein from Bacillus stearothermophilus (258 aa)%2C FASTA scores: opt: 594%2C E(): 2.8e-30%2C (37.45%25 identity in 267 aa overlap)%3B P37564|YACB_BACSU from Bacillus subtilis (233 aa)%2C FASTA scores: opt: 522%2C E(): 8.8e-26%2C (38.95%25 identity in 213 aa overlap)%3B Q9RX54|DR0461 conserved hypothetical protein from Deinococcus radiodurans (262 aa)%2C FASTA scores: opt: 503%2CE(): 1.5e-24%2C (38.45%25 identity in 268 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3600c;product=Conserved protein;protein_id=CCP46423.1;transl_table=11
AL123456.3	EMBL	gene	4043862	4044281	.	-	.	ID=gene-Rv3601c;Name=panD;gbkey=Gene;gene=panD;gene_biotype=protein_coding;locus_tag=Rv3601c
AL123456.3	EMBL	CDS	4043862	4044281	.	-	0	ID=cds-CCP46424.1;Parent=gene-Rv3601c;Dbxref=EnsemblGenomes-Gn:Rv3601c,EnsemblGenomes-Tr:CCP46424,GOA:P9WIL3,InterPro:IPR003190,InterPro:IPR009010,PDB:2C45,NCBI_GP:CCP46424.1;Name=CCP46424.1;Note=Rv3601c%2C (MTCY07H7B.21)%2C len: 139 aa. Probable panD%2Caspartate 1-decarboxylase%2C identical to Q9CD57|PAND|ML0231 putative aspartate-1-decarboxylase from Mycobacterium leprae (142 aa)%2C FASTA scores: opt: 733%2C E(): 5.5e-41%2C(82.85%25 identity in 140 aa overlap). Also highly similar to many e.g. CAC44328|PAND from Streptomyces coelicolor (139 aa)%2C FASTA scores: opt: 578%2C E(): 6.4e-31%2C (75.0%25 identity in 120 aa overlap)%3B Q9X4N0|PAND from Corynebacterium glutamicum (Brevibacterium flavum) (136 aa)%2C FASTA scores: opt: 506%2C E(): 3e-26%2C (62.2%25 identity in 135 aa overlap)%3B P52999|PAND_BACSU from Bacillus subtilis (127 aa) FASTA scores: opt: 421%2C E(): 9.6e-21%2C (54.75%25 identity in 123 aa overlap)%3B P31664|PAND_ECOLI|B0131 from Escherichia coli strain K12 (126 aa)%2C FASTA scores: opt: 388%2C E(): 1.3e-18%2C(50.45%25 identity in 113 aa overlap)%3B etc.;gbkey=CDS;gene=panD;locus_tag=Rv3601c;product=Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase);protein_id=CCP46424.1;transl_table=11
AL123456.3	EMBL	gene	4044281	4045210	.	-	.	ID=gene-Rv3602c;Name=panC;gbkey=Gene;gene=panC;gene_biotype=protein_coding;locus_tag=Rv3602c
AL123456.3	EMBL	CDS	4044281	4045210	.	-	0	ID=cds-CCP46425.1;Parent=gene-Rv3602c;Dbxref=EnsemblGenomes-Gn:Rv3602c,EnsemblGenomes-Tr:CCP46425,GOA:P9WIL5,InterPro:IPR003721,InterPro:IPR014729,PDB:1MOP,PDB:1N2B,PDB:1N2E,PDB:1N2G,PDB:1N2H,PDB:1N2I,PDB:1N2J,PDB:1N2O,PDB:2A7X,PDB:2A84,PDB:2A86,PDB:2A88,PDB:3COV,PDB:3COW,PDB:3COY,PDB:3COZ,PDB:3IMC,PDB:3IME,PDB:3IMG,PDB:3IOB,PDB:3IOC,PDB:3IOD,PDB:3IOE,PDB:3ISJ,PDB:3IUB,PDB:3IUE,PDB:3IVC,PDB:3IVG,PDB:3IVX,PDB:3LE8,PDB:4DDH,PDB:4DDK,PDB:4DDM,PDB:4DE5,PDB:4EF6,PDB:4EFK,PDB:4FZJ,PDB:4G5F,PDB:4G5Y,NCBI_GP:CCP46425.1;Name=CCP46425.1;Note=Rv3602c%2C (MTCY07H7B.20)%2C len: 309 aa. panC%2Cpantoate--beta-alanine ligase%2C equivalent to O69524|PANC_MYCLE|ML0230|MLCB2548.01c pantoate--beta-alanine ligase from Mycobacterium leprae (313 aa)%2C FASTA scores: opt: 1541%2C E(): 3.4e-84%2C (82.15%25 identity in 297 aa overlap). Also similar to others e.g. O67891|PANC_AQUAE|AQ_2132 from Aquifex aeolicus (282 aa) FASTA scores: opt: 774%2C E(): 8.6e-39%2C (46.9%25 identity in 273 aa overlap)%3B Q9HV69|PANC_PSEAE|PA4730 from Pseudomonas aeruginosa (283 aa)%2C FASTA scores: opt: 770%2C E(): 1.5e-38%2C(51.45%25 identity in 276 aa overlap)%3B Q9A6C8|CC2166 from Caulobacter crescentus (285 aa)%2C FASTA scores: opt: 744%2CE(): 5.2e-37%2C (47.75%25 identity in 268 aa overlap)%3B P31663|PANC_ECOLI|B0133 from Escherichia coli strain K12 (283 aa)%2C FASTA scores: opt: 695%2C E(): 4.1e-34%2C (46.1%25 identity in 271 aa overlap)%3B etc. Belongs to the pantothenate synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=panC;locus_tag=Rv3602c;product=Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme);protein_id=CCP46425.1;transl_table=11
AL123456.3	EMBL	gene	4045207	4046118	.	-	.	ID=gene-Rv3603c;Name=Rv3603c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3603c
AL123456.3	EMBL	CDS	4045207	4046118	.	-	0	ID=cds-CCP46426.1;Parent=gene-Rv3603c;Dbxref=EnsemblGenomes-Gn:Rv3603c,EnsemblGenomes-Tr:CCP46426,GOA:O06279,InterPro:IPR008927,InterPro:IPR016040,InterPro:IPR018931,InterPro:IPR019665,UniProtKB/TrEMBL:O06279,NCBI_GP:CCP46426.1;Name=CCP46426.1;Note=Rv3603c%2C (MTCY07H7B.19)%2C len: 303 aa. Conserved hypothetical ala-%2C leu-rich protein%2C identical except at N-terminus (really different) to AAK48066|MT3708 chalcone/stilbene synthase family protein from Mycobacterium tuberculosis strain CDC1551 (361 aa) FASTA scores: opt: 1742%2C E(): 8.3e-95%2C (100.0%25 identity in 275 aa overlap). Equivalent to O69525|MLCB2548.02c|ML0229 hypothetical 32.7 KDA protein from Mycobacterium leprae (309 aa)%2C FASTA scores: opt: 947%2C E(): 2.4e-48%2C (67.85%25 identity in 311 aa overlap). Also highly similar to Q9X845|SCE126.02c hypothetical 42.2 KDA protein from Streptomyces coelicolor (420 aa)%2C FASTA scores: opt: 683%2CE(): 8.5e-33%2C (49.3%25 identity in 284 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3603c;product=Conserved hypothetical alanine and leucine rich protein;protein_id=CCP46426.1;transl_table=11
AL123456.3	EMBL	gene	4046303	4047496	.	-	.	ID=gene-Rv3604c;Name=Rv3604c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3604c
AL123456.3	EMBL	CDS	4046303	4047496	.	-	0	ID=cds-CCP46427.1;Parent=gene-Rv3604c;Dbxref=EnsemblGenomes-Gn:Rv3604c,EnsemblGenomes-Tr:CCP46427,GOA:O06278,UniProtKB/TrEMBL:O06278,NCBI_GP:CCP46427.1;Name=CCP46427.1;Note=Rv3604c%2C (MTCY07H7B.18)%2C len: 397 aa. Probable conserved ala-%2C arg-%2C pro-rich transmembrane protein%2Cequivalent to O69526|MLCB2548.03c|ML0228 putative membrane protein from Mycobacterium leprae (432 aa)%2C FASTA scores: opt: 869%2C E(): 2.9e-31%2C (59.7%25 identity in 432 aa overlap). Contains two possible membrane-spanning domains. N-terminus shortened since first submission (previously 462 aa). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3604c;product=Probable conserved transmembrane protein rich in alanine and arginine and proline;protein_id=CCP46427.1;transl_table=11
AL123456.3	EMBL	gene	4047705	4048181	.	-	.	ID=gene-Rv3605c;Name=Rv3605c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3605c
AL123456.3	EMBL	CDS	4047705	4048181	.	-	0	ID=cds-CCP46428.1;Parent=gene-Rv3605c;Dbxref=EnsemblGenomes-Gn:Rv3605c,EnsemblGenomes-Tr:CCP46428,InterPro:IPR021517,UniProtKB/TrEMBL:O06277,NCBI_GP:CCP46428.1;Name=CCP46428.1;Note=Rv3605c%2C (MTCY07H7B.17)%2C len: 158 aa. Probable conserved secreted or membrane protein%2C identical to O69527|MLCB2548.04c|ML0227 putative membrane protein from Mycobacterium leprae (158 aa)%2C FASTA scores: opt: 944%2C E(): 2.6e-56%2C (85.45%25 identity in 158 aa overlap). Also similar to other proteins e.g. Q9X8I2|SCE9.09 possible secreted protein from Streptomyces coelicolor (162 aa)%2C FASTA scores: opt: 174%2C E(): 9.2e-05%2C (31.25%25 identity in 128 aa overlap)%3B etc. Contains possible N-terminal signal sequence. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv3605c;product=Probable conserved secreted protein;protein_id=CCP46428.1;transl_table=11
AL123456.3	EMBL	gene	4048181	4048747	.	-	.	ID=gene-Rv3606c;Name=folK;gbkey=Gene;gene=folK;gene_biotype=protein_coding;locus_tag=Rv3606c
AL123456.3	EMBL	CDS	4048181	4048747	.	-	0	ID=cds-CCP46429.1;Parent=gene-Rv3606c;Dbxref=EnsemblGenomes-Gn:Rv3606c,EnsemblGenomes-Tr:CCP46429,GOA:P9WNC7,InterPro:IPR000550,NCBI_GP:CCP46429.1;Name=CCP46429.1;Note=Rv3606c%2C (MTCY07H7B.16)%2C len: 188 aa. Probable folK%2C2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase%2C equivalent to O69528|HPPK_MYCLE|folk|ML0226\MLCB2548.05c 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase from Mycobacterium leprae (191 aa) FASTA scores: opt: 772%2C E(): 1.2e-44%2C (63.15%25 identity in 190 aa overlap). Also similar to many e.g. P71512|HPPK_METEX|folk|FOLA from Methylobacterium extorquens (158 aa)%2C FASTA scores: opt: 292%2C E(): 1.4e-12%2C(36.85%25 identity in 171 aa overlap)%3B O33726|HPPK_STRPY|folk|SPY1100 from Streptococcus pyogenes (166 aa)%2C FASTA scores: opt: 234%2C E(): 1.1e-08%2C (34.3%25 identity in 175 aa overlap)%3B Q9X8I1|SCE9.08 from Streptomyces coelicolor (203 aa)%2C FASTA scores: opt: 232%2CE(): 1.7e-08%2C (43.25%25 identity in 185 aa overlap)%3B P26281|HPPK_ECOLI|folk|B0142 from Escherichia coli strain K12 (158 aa)%2C FASTA scores: opt: 198%2C E(): 2.6e-06%2C (32.85%25 identity in 143 aa overlap)%3B etc. Belongs to the HppK family.;gbkey=CDS;gene=folK;locus_tag=Rv3606c;product=2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase FolK (7%2C8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7%2C8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7%2C8-dihydropterin diphosphokinase);protein_id=CCP46429.1;transl_table=11
AL123456.3	EMBL	gene	4048744	4049145	.	-	.	ID=gene-Rv3607c;Name=folB;gbkey=Gene;gene=folB;gene_biotype=protein_coding;gene_synonym=folX;locus_tag=Rv3607c
AL123456.3	EMBL	CDS	4048744	4049145	.	-	0	ID=cds-CCP46430.1;Parent=gene-Rv3607c;Dbxref=EnsemblGenomes-Gn:Rv3607c,EnsemblGenomes-Tr:CCP46430,GOA:P9WNC5,InterPro:IPR006156,InterPro:IPR006157,PDB:1NBU,PDB:1Z9W,NCBI_GP:CCP46430.1;Name=CCP46430.1;Note=Rv3607c%2C (MTCY07H7B.15)%2C len: 133 aa. Probable folB%2Cdihydroneopterin aldolase%2C equivalent to O69529|FOLB_MYCLE|ML0225|MLCB2548.06c probable dihydroneopterin aldolase from Mycobacterium leprae (132 aa)%2C FASTA scores: opt: 673%2C E(): 5.1e-37%2C (74.8%25 identity in 131 aa overlap). Also similar to many e.g. Q9X8I0|FOLB_STRCO|SCE9.07 from Streptomyces coelicolor (119 aa)%2C FASTA scores: opt: 334%2C E(): 4.5e-15%2C (46.15%25 identity in 117 aa overlap)%3B P74342|FOLB_SYNY3|SLR1626 from Synechocystis sp. strain PCC 6803 (118 aa) FASTA scores: opt: 287%2C E(): 5e-12%2C (38.45%25 identity in 117 aa overlap)%3B P28823|FOLB_BACSU|FOLA from Bacillus subtilis (120 aa)%2CFASTA scores: opt: 283%2C E(): 9.2e-12%2C (39.0%25 identity in 118 aa overlap)%3B etc. Belongs to the DHNA family. Note that previously known as folX.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=folB;locus_tag=Rv3607c;product=Probable dihydroneopterin aldolase FolB (DHNA);protein_id=CCP46430.1;transl_table=11
AL123456.3	EMBL	gene	4049138	4049980	.	-	.	ID=gene-Rv3608c;Name=folP1;gbkey=Gene;gene=folP1;gene_biotype=protein_coding;locus_tag=Rv3608c
AL123456.3	EMBL	CDS	4049138	4049980	.	-	0	ID=cds-CCP46431.1;Parent=gene-Rv3608c;Dbxref=EnsemblGenomes-Gn:Rv3608c,EnsemblGenomes-Tr:CCP46431,GOA:P9WND1,InterPro:IPR000489,InterPro:IPR006390,InterPro:IPR011005,PDB:1EYE,NCBI_GP:CCP46431.1;Name=CCP46431.1;Note=Rv3608c%2C (MTCY07H7B.14)%2C len: 280 aa. Probable folP1%2C dihydropteroate synthase 1%2C equivalent to O69530|FOLP (alias Q9S0T0|FOLP and Q9R2U9|FOLP) dihydroneopterin aldolase from Mycobacterium leprae (284 aa)%2C FASTA scores: opt: 1418%2C E(): 7.2e-77%2C (76.75%25 identity in 284 aa overlap). Also highly similar to many e.g. Q9X8H8|SCE9.05 from Streptomyces coelicolor (288 aa)%2CFASTA scores: opt: 953%2C E(): 2.4e-49%2C (56.0%25 identity in 266 aa overlap)%3B Q9A3I0|CC3224 from Caulobacter crescentus (274 aa)%2C FASTA scores: opt: 682%2C E(): 2.6e-33%2C (45.5%25 identity in 268 aa overlap)%3B P73248|DHPS_SYNY3|FOLP|SLR2026 from Synechocystis sp. strain PCC 6803 (289 aa)%2C FASTA scores: opt: 665%2C E(): 2.7e-32%2C (44.55%25 identity in 265 aa overlap)%3B P26282|DHPS_ECOLI|FOLP|B3177 from Escherichia coli strain K12 (282 aa)%2C FASTA scores: opt: 642%2C E(): 6.1e-31%2C (41.95%25 identity in 274 aa overlap)%3B etc. Contains PS00792 Dihydropteroate synthase signature 1%2C PS00793 Dihydropteroate synthase signature 2. Similar to other species DHPS.;gbkey=CDS;gene=folP1;inference=protein motif:PROSITE:PS00793;locus_tag=Rv3608c;product=Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1);protein_id=CCP46431.1;transl_table=11
AL123456.3	EMBL	gene	4049977	4050585	.	-	.	ID=gene-Rv3609c;Name=folE;gbkey=Gene;gene=folE;gene_biotype=protein_coding;gene_synonym=gchA;locus_tag=Rv3609c
AL123456.3	EMBL	CDS	4049977	4050585	.	-	0	ID=cds-CCP46432.1;Parent=gene-Rv3609c;Dbxref=EnsemblGenomes-Gn:Rv3609c,EnsemblGenomes-Tr:CCP46432,GOA:P9WN57,InterPro:IPR001474,InterPro:IPR018234,InterPro:IPR020602,NCBI_GP:CCP46432.1;Name=CCP46432.1;Note=Rv3609c%2C (MTCY07H7B.13)%2C len: 202 aa. Probable folE (alternate gene name: gchA)%2C GTP cyclohydrolase I%2Cequivalent to O69531|GCH1_MYCLE|FOLE|ML0223|MLCB2548.08c GTP cyclohydrolase I from Mycobacterium leprae (205 aa) FASTA scores: opt: 1112%2C E(): 3.8e-63%2C (81.95%25 identity in 205 aa overlap). Also highly similar to many e.g. Q9X8I3|GCH1_STRCO|FOLE|SCE9.10c from Streptomyces coelicolor (201 aa)%2C FASTA scores: opt: 873%2C E(): 4.2e-48%2C(67.4%25 identity in 187 aa overlap)%3B Q9KCC7|MTRA|BH1646 from Bacillus halodurans (188 aa)%2C FASTA scores: opt: 757%2C E(): 8.1e-41%2C (62.3%25 identity in 183 aa overlap)%3B P19465|GCH1_BACSU|FOLE|MTRA from Bacillus subtilis (190 aa)%2C FASTA scores: opt: 750%2C E(): 2.3e-40%2C (58.95%25 identity in 190 aa overlap)%3B etc. Contains PS00860 GTP cyclohydrolase I signature 2. Belongs to the GTP cyclohydrolase I family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=folE;inference=protein motif:PROSITE:PS00860;locus_tag=Rv3609c;product=GTP cyclohydrolase I FolE (GTP-ch-I);protein_id=CCP46432.1;transl_table=11
AL123456.3	EMBL	gene	4050601	4052883	.	-	.	ID=gene-Rv3610c;Name=ftsH;gbkey=Gene;gene=ftsH;gene_biotype=protein_coding;locus_tag=Rv3610c
AL123456.3	EMBL	CDS	4050601	4052883	.	-	0	ID=cds-CCP46433.1;Parent=gene-Rv3610c;Dbxref=EnsemblGenomes-Gn:Rv3610c,EnsemblGenomes-Tr:CCP46433,GOA:P9WQN3,InterPro:IPR000642,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR003960,InterPro:IPR005936,InterPro:IPR027417,NCBI_GP:CCP46433.1;Name=CCP46433.1;Note=Rv3610c%2C (MT3714%2C MTCY07H7B.12)%2C len: 760 aa. FtsH%2Cmembrane-bound protease (cell division protein) (see citations below)%2C equivalent to Q9CD58|FTSH_MYCLE|ML0222 (alias O69532|FTSH) cell division protein FTSH homolog from Mycobacterium leprae (787 aa)%2C FASTA scores: opt: 4388%2CE(): 9.6e-205%2C (87.2%25 identity in 790 aa overlap). Also highly similar to many FTSH proteins e.g. O52395|FTSH from Mycobacterium smegmatis (769 aa)%2C FASTA scores: opt: 3976%2CE(): 7.6e-185%2C (82.4%25 identity in 761 aa overlap)%3B Q9X8I4|SCE9.11c from Streptomyces coelicolor (668 aa)%2CFASTA scores: opt: 2417%2C E(): 1.4e-109%2C (57.2%25 identity in 668 aa overlap)%3B P72991|FTH4_SYNY3|SLR1604 from Synechocystis sp. strain PCC 6803 (616 aa)%2C FASTA scores: opt: 1926%2C E(): 7.2e-86%2C (49.35%25 identity in 612 aa overlap)%3B P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from Escherichia coli strain K12 (644 aa)%2C FASTA scores: opt: 1859%2C E(): 1.3e-82%2C (48.95%25 identity in 605 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C and PS00674 AAA-protein family signature. Belongs to the AAA family of ATPases and peptidase family M41 (zinc metalloprotease). Cofactor: binds one zinc ion (potential). Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ftsH;inference=protein motif:PROSITE:PS00674;locus_tag=Rv3610c;product=Membrane-bound protease FtsH (cell division protein);protein_id=CCP46433.1;transl_table=11
AL123456.3	EMBL	repeat_region	4052949	4052966	.	-	.	ID=id-AL123456.3:4052949..4052966;Note=18 bp direct repeat 2%2C GGGTTTGCGATCGCCACG;gbkey=repeat_region
AL123456.3	EMBL	gene	4052950	4053603	.	+	.	ID=gene-Rv3611;Name=Rv3611;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3611
AL123456.3	EMBL	CDS	4052950	4053603	.	+	0	ID=cds-CCP46434.1;Parent=gene-Rv3611;Dbxref=EnsemblGenomes-Gn:Rv3611,EnsemblGenomes-Tr:CCP46434,GOA:O06272,UniProtKB/TrEMBL:O06272,NCBI_GP:CCP46434.1;Name=CCP46434.1;Note=Rv3611%2C (MTCY07H7B.11c)%2C len: 217 aa. Hypothetical unknown arg-%2C pro-rich protein. Possible ORF containing several direct repeats.;gbkey=CDS;locus_tag=Rv3611;product=Hypothetical arginine and proline rich protein;protein_id=CCP46434.1;transl_table=11
AL123456.3	EMBL	repeat_region	4052971	4052994	.	-	.	ID=id-AL123456.3:4052971..4052994;Note=(24 bp) part of 111 bp direct repeat unit 6%2CGTGGCGACCCGCTGCACCCGGCTC;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	4052995	4053105	.	-	.	ID=id-AL123456.3:4052995..4053105;Note=111 bp direct repeat unit 5%2C GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	4053004	4053021	.	-	.	ID=id-AL123456.3:4053004..4053021;Note=18 bp direct repeat 1%2C GGGTTTGCGATCGCCACG;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	4053106	4053216	.	-	.	ID=id-AL123456.3:4053106..4053216;Note=111 bp direct repeat unit 4%2C GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	4053217	4053327	.	-	.	ID=id-AL123456.3:4053217..4053327;Note=111 bp direct repeat unit 3%2C GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	4053328	4053438	.	-	.	ID=id-AL123456.3:4053328..4053438;Note=111 bp direct repeat unit 2%2C GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	4053439	4053549	.	-	.	ID=id-AL123456.3:4053439..4053549;Note=111 bp direct repeat unit 1%2C GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG;gbkey=repeat_region
AL123456.3	EMBL	gene	4053518	4053847	.	-	.	ID=gene-Rv3612c;Name=Rv3612c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3612c
AL123456.3	EMBL	CDS	4053518	4053847	.	-	0	ID=cds-CCP46435.1;Parent=gene-Rv3612c;Dbxref=EnsemblGenomes-Gn:Rv3612c,EnsemblGenomes-Tr:CCP46435,UniProtKB/TrEMBL:I6YGR2,NCBI_GP:CCP46435.1;Name=CCP46435.1;Note=Rv3612c%2C (MTCY07H7B.10)%2C len: 109 aa. Conserved hypothetical protein. Residues 58 to 81 highly similar to N-terminal part of AAK46718|MT2424 hypothetical 3.9 KDA protein from Mycobacterium tuberculosis strain CDC1551 (36 aa)%2C FASTA scores: opt: 108%2C E(): 0.38%2C (69.25%25 identity in 26 aa overlap).;gbkey=CDS;locus_tag=Rv3612c;product=Conserved hypothetical protein;protein_id=CCP46435.1;transl_table=11
AL123456.3	EMBL	gene	4053881	4054042	.	-	.	ID=gene-Rv3613c;Name=Rv3613c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3613c
AL123456.3	EMBL	CDS	4053881	4054042	.	-	0	ID=cds-CCP46436.1;Parent=gene-Rv3613c;Dbxref=EnsemblGenomes-Gn:Rv3613c,EnsemblGenomes-Tr:CCP46436,UniProtKB/TrEMBL:O06270,NCBI_GP:CCP46436.1;Name=CCP46436.1;Note=Rv3613c%2C (MTCY07H7B.09)%2C len: 53 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3613c;product=Hypothetical protein;protein_id=CCP46436.1;transl_table=11
AL123456.3	EMBL	gene	4054142	4054696	.	-	.	ID=gene-Rv3614c;Name=espD;gbkey=Gene;gene=espD;gene_biotype=protein_coding;gene_synonym=snm10;locus_tag=Rv3614c
AL123456.3	EMBL	CDS	4054142	4054696	.	-	0	ID=cds-CCP46437.1;Parent=gene-Rv3614c;Dbxref=EnsemblGenomes-Gn:Rv3614c,EnsemblGenomes-Tr:CCP46437,GOA:P9WJD5,NCBI_GP:CCP46437.1;Name=CCP46437.1;Note=Rv3614c%2C (MTCY07H7B.08)%2C len: 184 aa. EspD%2C ESX-1 secretion-associated protein%2C equivalent to Q49730|ML0407|B1620_C3_264|MLCL383.03 hypothetical 24.2 KDA protein from Mycobacterium leprae (216 aa) FASTA scores: opt: 899%2C E(): 1.7e-51%2C (71.3%25 identity in 188 aa overlap)%3B and similar to two hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa)%2C FASTA scores: opt: 285%2CE(): 1.2e-11%2C (38.35%25 identity in 172 aa overlap)%3B and O33090|MLCB628.19c (338 aa)%2C FASTA scores: opt: 289%2C E(): 1.2e-11%2C (38.95%25 identity in 172 aa overlap). Also highly similar to O69732|Rv3867|MTV027.02 hypothetical 19.9 KDA protein from Mycobacterium tuberculosis (183 aa)%2C FASTA scores: opt: 563%2C E(): 1e-29%2C (54.9%25 identity in 173 aa overlap). Rv3614c and Rv3882c interact%2C by yeast two-hybrid analysis (See MacGurn et al.%2C 2005). EspD|Rv3614c is still secreted by M. tuberculosis H37Rv and Erdman ESX-1 secretion system mutants%2C but at levels lower than in wild-type (See Chen et al.%2C 2012).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espD;locus_tag=Rv3614c;product=ESX-1 secretion-associated protein EspD;protein_id=CCP46437.1;transl_table=11
AL123456.3	EMBL	gene	4054812	4055123	.	-	.	ID=gene-Rv3615c;Name=espC;gbkey=Gene;gene=espC;gene_biotype=protein_coding;gene_synonym=snm9;locus_tag=Rv3615c
AL123456.3	EMBL	CDS	4054812	4055123	.	-	0	ID=cds-CCP46438.1;Parent=gene-Rv3615c;Dbxref=EnsemblGenomes-Gn:Rv3615c,EnsemblGenomes-Tr:CCP46438,GOA:P9WJD7,InterPro:IPR022536,NCBI_GP:CCP46438.1;Name=CCP46438.1;Note=Rv3615c%2C (MTCY07H7B.07)%2C len: 103 aa. EspC%2C ESX-1 secretion-associated protein%2C equivalent to Q49723|ML0406|B1620_C2_214|MLCL383 hypothetical 11.1 KDA protein from Mycobacterium leprae (106 aa)%2C FASTA scores: opt: 364%2C E(): 4.1e-18%2C (60.85%25 identity in 92 aa overlap). Also shows similarity to P96212|Rv3865|MTCY01A6.03 hypothetical 10.6 KDA protein from Mycobacterium tuberculosis (103 aa)%2C FASTA scores: opt: 198%2C E(): 6.8e-07%2C (36.25%25 identity in 102 aa overlap). Has been shown to interact with itself%2C by yeast two-hybrid analysis (See MacGurn et al.%2C 2005).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espC;locus_tag=Rv3615c;product=ESX-1 secretion-associated protein EspC;protein_id=CCP46438.1;transl_table=11
AL123456.3	EMBL	gene	4055197	4056375	.	-	.	ID=gene-Rv3616c;Name=espA;gbkey=Gene;gene=espA;gene_biotype=protein_coding;locus_tag=Rv3616c
AL123456.3	EMBL	CDS	4055197	4056375	.	-	0	ID=cds-CCP46439.1;Parent=gene-Rv3616c;Dbxref=EnsemblGenomes-Gn:Rv3616c,EnsemblGenomes-Tr:CCP46439,GOA:P9WJE1,NCBI_GP:CCP46439.1;Name=CCP46439.1;Note=Rv3616c%2C (MTCY07H7B.06)%2C len: 392 aa. EspA%2C ESX-1 secretion-associated protein A. Ala-%2C gly-rich protein%2Cequivalent to Q49722|ML0405|B1620_C2_213|MLCL383.01 hypothetical 40.8 KDA protein from Mycobacterium leprae (394 aa) FASTA scores: opt: 1620%2C E(): 5.3e-75%2C (62.7%25 identity in 394 aa overlap). Also similar to P96213|Rv3864|MTCY01A6.04c hypothetical 42.1 KDA protein from Mycobacterium tuberculosis (402 aa)%2C FASTA scores: opt: 389%2C E(): 1.1e-12%2C (31.75%25 identity in 400 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espA;locus_tag=Rv3616c;product=ESX-1 secretion-associated protein A%2C EspA;protein_id=CCP46439.1;transl_table=11
AL123456.3	EMBL	gene	4057733	4058701	.	+	.	ID=gene-Rv3617;Name=ephA;gbkey=Gene;gene=ephA;gene_biotype=protein_coding;locus_tag=Rv3617
AL123456.3	EMBL	CDS	4057733	4058701	.	+	0	ID=cds-CCP46440.1;Parent=gene-Rv3617;Dbxref=EnsemblGenomes-Gn:Rv3617,EnsemblGenomes-Tr:CCP46440,GOA:I6YGS0,InterPro:IPR000639,InterPro:IPR029058,UniProtKB/TrEMBL:I6YGS0,NCBI_GP:CCP46440.1;Name=CCP46440.1;Note=Rv3617%2C (MTCY07H7B.05c%2C MTCY15C10.35c)%2C len: 322 aa. Probable ephA%2C epoxide hydrolase (see citation below)%2Csimilar to many e.g. Q9A8W9|CC1229 from Caulobacter crescentus (330 aa)%2C FASTA scores: opt: 965%2C E(): 1.8e-51%2C(46.15%25 identity in 323 aa overlap)%3B Q9M9W5|F18C1.13 from Arabidopsis thaliana (Mouse-ear cress) (331 aa)%2C FASTA scores: opt: 778%2C E(): 4.3e-40%2C (40.35%25 identity in 332 aa overlap)%3B Q9S7P1 from Oryza sativa (Rice) (322 aa)%2C FASTA scores: opt: 774%2C E(): 7.4e-40%2C (41.1%25 identity in 321 aa overlap)%3B P80299|HYES_RAT|EPHX2 from Rattus norvegicus (Rat) (554 aa)%2C FASTA scores: opt: 759%2C E(): 9.5e-39%2C(40.5%25 identity in 306 aa overlap) (similarity only with the C-terminal part for this one)%3B etc. Similar to alpha/beta hydrolase fold. Contains PS00888 Cyclic nucleotide-binding domain signature 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ephA;inference=protein motif:PROSITE:PS00888;locus_tag=Rv3617;product=Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase);protein_id=CCP46440.1;transl_table=11
AL123456.3	EMBL	gene	4058698	4059885	.	+	.	ID=gene-Rv3618;Name=Rv3618;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3618
AL123456.3	EMBL	CDS	4058698	4059885	.	+	0	ID=cds-CCP46441.1;Parent=gene-Rv3618;Dbxref=EnsemblGenomes-Gn:Rv3618,EnsemblGenomes-Tr:CCP46441,GOA:I6X7W8,InterPro:IPR011251,UniProtKB/TrEMBL:I6X7W8,NCBI_GP:CCP46441.1;Name=CCP46441.1;Note=Rv3618%2C (MTCY15C10.34c%2C MTCY07H7B.04c)%2C len: 395 aa. Possible monooxygenase%2C similar to others (principally bacterial luciferases alpha chain) e.g. Q9JN87|MMYO putative alkanal monooxygenase from Streptomyces coelicolor (373 aa)%2C FASTA scores: opt: 949%2C E(): 8.9e-54%2C (41.7%25 identity in 374 aa overlap)%3B Q9EUT9|limb limonene monooxygenase from Rhodococcus erythropolis (387 aa)%2C FASTA scores: opt: 856%2C E(): 9.1e-48%2C (42.0%25 identity in 388 aa overlap)%3B AAK72698 LUXA-like protein from Bradyrhizobium japonicum (458 aa) FASTA scores: opt: 350%2C E(): 4.4e-15%2C(29.7%25 identity in 347 aa overlap)%3B Q9K4C1|2SC6G5.34c putative alkanal monooxygenase (luciferase) from Streptomyces coelicolor (342 aa)%2C FASTA scores: opt: 291%2CE(): 2.2e-11%2C (26.5%25 identity in 362 aa overlap)%3B etc. Also similar to P95278|Rv1936|MTCY09F9.28c hypothetical 41.8 KDA protein from Mycobacterium tuberculosis (369 aa)%2C FASTA scores: opt: 473%2C E(): 4.3e-23%2C (32.55%25 identity in 378 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3618;product=Possible monooxygenase;protein_id=CCP46441.1;transl_table=11
AL123456.3	EMBL	gene	4059984	4060268	.	-	.	ID=gene-Rv3619c;Name=esxV;gbkey=Gene;gene=esxV;gene_biotype=protein_coding;gene_synonym=ES6_1,Mtb9.9D;locus_tag=Rv3619c
AL123456.3	EMBL	CDS	4059984	4060268	.	-	0	ID=cds-CCP46442.1;Parent=gene-Rv3619c;Dbxref=EnsemblGenomes-Gn:Rv3619c,EnsemblGenomes-Tr:CCP46442,GOA:P9WNK1,InterPro:IPR009416,InterPro:IPR010310,NCBI_GP:CCP46442.1;Name=CCP46442.1;Note=Rv3619c%2C (MTCY15C10.33%2C MTCY07H7B.03%2C MT3721)%2C len: 94 aa. EsxV%2C ESAT-6 like protein (see citations below)%2Chighly similar to many Mycobacterial ESAT-6 like proteins e.g. O53942|ES65_MYCTU putative ESAT-6 like protein 5 from Mycobacterium tuberculosis (94 aa)%2C FASTA scores: opt: 582%2CE(): 4.4e-33%2C (92.55%25 identity in 94 aa overlap)%3B Q49946|ES6X_MYCLE|U1756D putative ESAT-6 like protein X from Mycobacterium leprae (95 aa)%2C FASTA scores: opt: 409%2CE(): 2.5e-21%2C (64.15%25 identity in 92 aa overlap)%3B etc. Strictly identical to P96364|ES61_MYCTU|Rv1037c|MT1066|MTCY10G2.12 putative ESAT-6 like protein 1 (94 aa). Belongs to the ESAT6 family. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=esxV;locus_tag=Rv3619c;product=Putative ESAT-6 like protein EsxV (ESAT-6 like protein 1);protein_id=CCP46442.1;transl_table=11
AL123456.3	EMBL	gene	4060295	4060591	.	-	.	ID=gene-Rv3620c;Name=esxW;gbkey=Gene;gene=esxW;gene_biotype=protein_coding;gene_synonym=ES6_10,QILSS;locus_tag=Rv3620c
AL123456.3	EMBL	CDS	4060295	4060591	.	-	0	ID=cds-CCP46443.1;Parent=gene-Rv3620c;Dbxref=EnsemblGenomes-Gn:Rv3620c,EnsemblGenomes-Tr:CCP46443,InterPro:IPR010310,NCBI_GP:CCP46443.1;Name=CCP46443.1;Note=Rv3620c%2C (MTCY15C10.32%2C MTCY07H7B.02%2C MT3722)%2C len: 98 aa. EsxW%2C ESAT-6 like protein (see citation below). Member of the M. tuberculosis hypothetical QILSS protein family with Rv1038c%2C Rv1792%2C Rv2347c and Rv1197|O05299|ES63_MYCTU|MT1235|MTCI364.09 putative ESAT-6 like protein 3 from Mycobacterium tuberculosis (98 aa)%2CFASTA scores: opt: 638%2C E(): 2.3e-36%2C (97.95%25 identity in 98 aa overlap). Also similar to Q49945|ES6Y_MYCLE putative ESAT-6 like protein Y from Mycobacterium leprae (100 aa)%2CFASTA scores: opt: 370%2C E(): 2.1e-18%2C (57.9%25 identity in 95 aa overlap)%3B etc. Belongs to the ESAT6 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxW;locus_tag=Rv3620c;product=Putative ESAT-6 like protein EsxW (ESAT-6 like protein 10);protein_id=CCP46443.1;transl_table=11
AL123456.3	EMBL	gene	4060648	4061889	.	-	.	ID=gene-Rv3621c;Name=PPE65;gbkey=Gene;gene=PPE65;gene_biotype=protein_coding;locus_tag=Rv3621c
AL123456.3	EMBL	CDS	4060648	4061889	.	-	0	ID=cds-CCP46444.1;Parent=gene-Rv3621c;Dbxref=EnsemblGenomes-Gn:Rv3621c,EnsemblGenomes-Tr:CCP46444,InterPro:IPR000030,InterPro:IPR022171,NCBI_GP:CCP46444.1;Name=CCP46444.1;Note=Rv3621c%2C (MTCY15C10.31%2C MTCY07H7B.01)%2C len: 413 aa. PPE65%2C Member of the Mycobacterium tuberculosis PPE family%2Cala-%2C gly-rich proteins%2C similar to many e.g. Q10813|YS92_MYCTU|Rv2892c|MT2959|MTCY274.23c (408 aa) FASTA scores: opt: 955%2C E(): 1.8e-42%2C (44.45%25 identity in 423 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE65;locus_tag=Rv3621c;product=PPE family protein PPE65;protein_id=CCP46444.1;transl_table=11
AL123456.3	EMBL	gene	4061899	4062198	.	-	.	ID=gene-Rv3622c;Name=PE32;gbkey=Gene;gene=PE32;gene_biotype=protein_coding;locus_tag=Rv3622c
AL123456.3	EMBL	CDS	4061899	4062198	.	-	0	ID=cds-CCP46445.1;Parent=gene-Rv3622c;Dbxref=EnsemblGenomes-Gn:Rv3622c,EnsemblGenomes-Tr:CCP46445,InterPro:IPR000084,UniProtKB/TrEMBL:I6YGS7,NCBI_GP:CCP46445.1;Name=CCP46445.1;Note=Rv3622c%2C (MTCY15C10.30)%2C len: 99 aa. PE32%2C Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu%2C 2002)%2C but no glycine rich C-terminus present. Similar to others e.g. O53938|Rv1788|MTV049.10 (99 aa)%2CFASTA scores: opt: 376%2C E(): 7.1e-17%2C (65.6%25 identity in 96 aa overlap).;gbkey=CDS;gene=PE32;locus_tag=Rv3622c;product=PE family protein PE32;protein_id=CCP46445.1;transl_table=11
AL123456.3	EMBL	gene	4062527	4063249	.	+	.	ID=gene-Rv3623;Name=lpqG;gbkey=Gene;gene=lpqG;gene_biotype=protein_coding;locus_tag=Rv3623
AL123456.3	EMBL	CDS	4062527	4063249	.	+	0	ID=cds-CCP46446.1;Parent=gene-Rv3623;Dbxref=EnsemblGenomes-Gn:Rv3623,EnsemblGenomes-Tr:CCP46446,InterPro:IPR007497,UniProtKB/TrEMBL:I6X7X3,NCBI_GP:CCP46446.1;Name=CCP46446.1;Note=Rv3623%2C (MTCY15C10.29c)%2C len: 240 aa. Probable lpqG%2Cconserved lipoprotein%2C showing some similarity with hypothetical proteins e.g. Q57432 from Methanosarcina barkeri (251 aa)%2C FASTA scores: opt: 319%2C E(): 6.8e-12%2C(31.2%25 identity in 218 aa overlap)%3B Q9PEA5|XF1123 outer membrane protein from Xylella fastidiosa (242 aa) FASTA scores: opt: 312%2C E(): 1.7e-11%2C (28.25%25 identity in 237 aa overlap)%3B BAB49547|MLR2408 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (236 aa)%2C FASTA scores: opt: 304%2C E(): 5e-11%2C (27.05%25 identity in 244 aa overlap)%3B etc. Has suitable signal peptide and prokaryotic membrane lipoprotein lipid attachment site (PS00013).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqG;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3623;product=Probable conserved lipoprotein LpqG;protein_id=CCP46446.1;transl_table=11
AL123456.3	EMBL	gene	4063254	4063904	.	-	.	ID=gene-Rv3624c;Name=hpt;gbkey=Gene;gene=hpt;gene_biotype=protein_coding;gene_synonym=hprT;locus_tag=Rv3624c
AL123456.3	EMBL	CDS	4063254	4063904	.	-	0	ID=cds-CCP46447.1;Parent=gene-Rv3624c;Dbxref=EnsemblGenomes-Gn:Rv3624c,EnsemblGenomes-Tr:CCP46447,GOA:P9WHQ9,InterPro:IPR000836,InterPro:IPR005904,InterPro:IPR029057,NCBI_GP:CCP46447.1;Name=CCP46447.1;Note=Rv3624c%2C (MTCY15C10.28)%2C len: 216 aa. Hpt (alternate gene name: hprT)%2C hypoxanthine-guanine phosphoribosyltransferase (but seems to have a 35 aa extension at N-terminus)%2C equivalent to other mycobacterial hypoxanthine-guanine phosphoribosyltransferases e.g. P96794 from Mycobacterium avium (203 aa)%2C FASTA scores: opt: 1136%2CE(): 1.2e-65%2C (88.5%25 identity in 200 aa overlap)%3B and O69537|HPT|ML0214 from Mycobacterium leprae (213 aa)%2C FASTA scores: opt: 1115%2C E(): 2.8e-64%2C (81.6%25 identity in 212 aa overlap). Also similar to others e.g. Q9X8I5|SCE9.12c from Streptomyces coelicolor (187 aa)%2C FASTA scores: opt: 724%2CE(): 2.4e-39%2C (60.55%25 identity in 180 aa overlap)%3B P37472|HPRT_BACSU|HPT from Bacillus subtilis (180 aa) FASTA scores: opt: 574%2C E(): 9.1e-30%2C (48.6%25 identity in 181 aa overlap)%3B etc. Equivalent to AAK48087 from Mycobacterium tuberculosis strain CDC1551 (202 aa) but longer 14 aa. Contains PS00103 Purine/pyrimidine phosphoribosyltransferases signature. Belongs to the purine/pyrimidine phosphoribosyltransferase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hpt;inference=protein motif:PROSITE:PS00103;locus_tag=Rv3624c;product=Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphorylase) (imp diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase);protein_id=CCP46447.1;transl_table=11
AL123456.3	EMBL	gene	4063901	4064872	.	-	.	ID=gene-Rv3625c;Name=mesJ;gbkey=Gene;gene=mesJ;gene_biotype=protein_coding;locus_tag=Rv3625c
AL123456.3	EMBL	CDS	4063901	4064872	.	-	0	ID=cds-CCP46448.1;Parent=gene-Rv3625c;Dbxref=EnsemblGenomes-Gn:Rv3625c,EnsemblGenomes-Tr:CCP46448,GOA:P9WG53,InterPro:IPR011063,InterPro:IPR012094,InterPro:IPR012795,InterPro:IPR014729,InterPro:IPR015262,NCBI_GP:CCP46448.1;Name=CCP46448.1;Note=Rv3625c%2C (MT3727%2C MTCY15C10.27)%2C len: 323 aa. Possible mesJ%2C cell cycle protein%2C equivalent to O69538|Y0C5_MYCLE|ML0213|MLCB2548.18c hypothetical 34.1 KDA protein from Mycobacterium leprae (323 aa) FASTA scores: opt: 1592%2C E(): 9e-92%2C (78.0%25 identity in 327 aa overlap). Similar to bacterial hypothetical proteins Q9X8I6|SCE9.13c from Streptomyces coelicolor (352 aa) FASTA scores: opt: 705%2C E(): 1.4e-36%2C (47.85%25 identity in 305 aa overlap)%3B and Q9HXZ3|PA3638 from Pseudomonas aeruginosa (442 aa)%2C FASTA scores: opt: 382%2C E(): 2e-16%2C (40.6%25 identity in 271 aa overlap). But also similar (or with similarity) to bacterial cell cycle proteins (MESJ) e.g. Q9KPX0|VC2242 MESJ protein from Vibrio cholerae (440 aa)%2C FASTA scores: opt: 363%2C E(): 3e-15%2C (34.8%25 identity in 253 aa overlap)%3B Q9RV23|DR1207 (600 aa) cell cycle protein MESJ (putative/cytosine deaminase-related protein) from Deinococcus radiodurans (600 aa)%2C FASTA scores: opt: 310%2CE(): 7.6e-12%2C (36.6%25 identity in 265 aa overlap) (similar only at the N-terminal end)%3B Q9PFJ8|XF0659 cell cycle protein from Xylella fastidiosa (437 aa)%2C FASTA scores: opt: 301%2C E(): 2.1e-11%2C (35.05%25 identity in 271 aa overlap)%3B P52097|MESJ_ECOLI|B0188 putative cell cycle protein MESJ from Escherichia coli strain K12(432 aa) FASTA scores: opt: 299%2C E(): 2.8e-11%2C (34.65%25 identity in 277 aa overlap)%3B etc. Belongs to the UPF0072 (MESJ/YCF62) family.;gbkey=CDS;gene=mesJ;locus_tag=Rv3625c;product=Possible cell cycle protein MesJ;protein_id=CCP46448.1;transl_table=11
AL123456.3	EMBL	gene	4064851	4065903	.	-	.	ID=gene-Rv3626c;Name=Rv3626c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3626c
AL123456.3	EMBL	CDS	4064851	4065903	.	-	0	ID=cds-CCP46449.1;Parent=gene-Rv3626c;Dbxref=EnsemblGenomes-Gn:Rv3626c,EnsemblGenomes-Tr:CCP46449,GOA:O06381,InterPro:IPR018766,InterPro:IPR022454,UniProtKB/TrEMBL:O06381,NCBI_GP:CCP46449.1;Name=CCP46449.1;Note=Rv3626c%2C (MTCY15C10.26)%2C len: 350 aa. Conserved hypothetical protein%2C similar to Q9X8I7|SCE9.14c hypothetical protein from Streptomyces coelicolor (375 aa) FASTA scores: opt: 720%2C E(): 2.2e-38%2C (41.55%25 identity in 361 aa overlap)%3B and shows some similarity to Q9HPS0|VNG1497C hypothetical protein (317 aa) FASTA scores: opt: 226%2C E(): 4.5e-07%2C (29.7%25 identity in 347 aa overlap). Contains neutral zinc metallopeptidases%2C zinc-binding region signature (PS00142).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv3626c;product=Conserved hypothetical protein;protein_id=CCP46449.1;transl_table=11
AL123456.3	EMBL	gene	4065900	4067285	.	-	.	ID=gene-Rv3627c;Name=Rv3627c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3627c
AL123456.3	EMBL	CDS	4065900	4067285	.	-	0	ID=cds-CCP46450.1;Parent=gene-Rv3627c;Dbxref=EnsemblGenomes-Gn:Rv3627c,EnsemblGenomes-Tr:CCP46450,GOA:O06380,InterPro:IPR000667,InterPro:IPR012338,UniProtKB/TrEMBL:O06380,NCBI_GP:CCP46450.1;Name=CCP46450.1;Note=Rv3627c%2C (MTCY15C10.25)%2C len: 461 aa. Conserved ala-rich protein which may have cleavable signal peptide at N-terminal end. Equivalent to O69539|MLCB2548.20c|ML0211 hypothetical 47.2 KDA protein from Mycobacterium leprae (461 aa)%2C FASTA scores: opt: 2295%2C E(): 3.5e-116%2C (76.2%25 identity in 462 aa overlap)%3B and C-terminal end shows similarity with O05758|MLCB5.28c hypothetical 24.1 KDA protein from Mycobacterium leprae (225 aa)%2C FASTA scores: opt: 268%2C E(): 1.8e-07%2C (32.25%25 identity in 220 aa overlap). Also similar (or with similarity) to various proteins (notably penicillin binding proteins) e.g. Q9X8I8|SCE9.15c hypothetical 45.9 KDA protein from Streptomyces coelicolor (459 aa) FASTA scores: opt: 707%2CE(): 8.3e-31%2C (35.75%25 identity in 439 aa overlap)%3B Q9Z541|SC9B2.18c putative carboxypeptidase from Streptomyces coelicolor (451 aa)%2C FASTA scores: opt: 450%2CE(): 5.3e-17%2C (31.75%25 identity in 469 aa overlap)%3B Q9JVV4|NMA0665 putative peptidase from Neisseria meningitidis (serogroup A) (or Q9JY10|NMB1797 from serogroup B) (469 aa)%2C FASTA scores: opt: 269%2C E(): 3e-07%2C(26.15%25 identity in 463 aa overlap)%3B O85665|PBP3 penicillin binding protein 3 from Neisseria gonorrhoeae (469 aa)%2CFASTA scores: opt: 265%2C E(): 4.9e-07%2C (31.85%25 identity in 201 aa overlap)%3B P45161|PBP4_HAEIN|DACB|HI1330 penicillin-binding protein 4 precursor/peptidase (479 aa) FASTA scores: opt: 230%2C E(): 3.8e-05%2C (27.9%25 identity in 394 aa overlap)%3B P24228|PBP4_ECOLI|DACB|B3182 penicillin-binding protein 4 precursor from Escherichia coli strain K12 (477 aa)%2C FASTA scores: opt: 166%2C E(): 0.1%2C(28.2%25 identity in 408 aa overlap)%3B etc. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3627c;product=Conserved protein;protein_id=CCP46450.1;transl_table=11
AL123456.3	EMBL	gene	4067423	4067911	.	+	.	ID=gene-Rv3628;Name=ppa;gbkey=Gene;gene=ppa;gene_biotype=protein_coding;locus_tag=Rv3628
AL123456.3	EMBL	CDS	4067423	4067911	.	+	0	ID=cds-CCP46451.1;Parent=gene-Rv3628;Dbxref=EnsemblGenomes-Gn:Rv3628,EnsemblGenomes-Tr:CCP46451,GOA:P9WI55,InterPro:IPR008162,PDB:1SXV,PDB:1WCF,PDB:2UXS,NCBI_GP:CCP46451.1;Name=CCP46451.1;Note=Rv3628%2C (MTCY15C10.24)%2C len: 162 aa. Ppa%2C inorganic pyrophosphatase (see Triccas %26 Gicquel 2001)%2C identical to O69540|IPYR_MYCLEPPA|ML0210|MLCB2548.21 inorganic pyrophosphatase from Mycobacterium leprae (162 aa) FASTA scores: opt: 1018%2C E(): 1.3e-59%2C (89.5%25 identity in 162 aa overlap). Also highly similar to many bacterial pyrophosphatases e.g. Q9X8I9|IPYR_STRCO|PPA|SCE9.16 from Streptomyces coelicolor (163 aa)%2C FASTA scores: opt: 773%2CE(): 1.3e-43%2C (67.5%25 identity in 163 aa overlap)%3B O05545|IPYR_GLUOX|PPA from Gluconobacter oxydans (Gluconobacter suboxydans) (176 aa)%2C FASTA scores: opt: 553%2C E(): 3.2e-29%2C (53.8%25 identity in 145 aa overlap)%3B P77992|IPYR_THELI|PPA from Thermococcus litoralis (176 aa) FASTA scores: opt: 537%2C E(): 3.5e-28%2C (49.35%25 identity in 152 aa overlap)%3B P50308|IPYR_SULAC|PPA from Sulfolobus acidocaldarius (173 aa)%2C FASTA scores: opt: 518%2C E(): 6e-27%2C (45.3%25 identity in 159 aa overlap)%3B etc. Belongs to the PPASE family. Cofactor: requires the presence of divalent metal cation. Magnesium confers the highest activity. Binds 4 divalent cations per subunit (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ppa;locus_tag=Rv3628;product=Inorganic pyrophosphatase Ppa (pyrophosphate phospho-hydrolase) (PPASE) (inorganic diphosphatase) (diphosphate phospho-hydrolase);protein_id=CCP46451.1;transl_table=11
AL123456.3	EMBL	gene	4067957	4069054	.	-	.	ID=gene-Rv3629c;Name=Rv3629c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3629c
AL123456.3	EMBL	CDS	4067957	4069054	.	-	0	ID=cds-CCP46452.1;Parent=gene-Rv3629c;Dbxref=EnsemblGenomes-Gn:Rv3629c,EnsemblGenomes-Tr:CCP46452,InterPro:IPR007427,UniProtKB/TrEMBL:O06378,NCBI_GP:CCP46452.1;Name=CCP46452.1;Note=Rv3629c%2C (MTCY15C10.23)%2C len: 365 aa. Probable conserved integral membrane protein%2C equivalent to O69543|MLCB2548.26|ML0205 putative membrane protein from Mycobacterium leprae (356 aa)%2C FASTA scores: opt: 1547%2CE(): 3e-89%2C (66.2%25 identity in 361 aa overlap). Also similar to other membrane and hypothetical proteins e.g. CAC37534|SCIF3.15c putative integral membrane protein from Streptomyces coelicolor (363 aa)%2C FASTA scores: opt: 819%2CE(): 7.7e-44%2C (51.55%25 identity in 351 aa overlap)%3B Q9CGK3|YKJK hypothetical protein from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (339 aa) FASTA scores: opt: 683%2C E(): 2.2e-35%2C (48.3%25 identity in 350 aa overlap)%3B Q9KY24|SCC8A.24c putative integral membrane protein from Streptomyces coelicolor (380 aa) FASTA scores: opt: 528%2C E(): 1.1e-25%2C (50.25%25 identity in 372 aa overlap)%3B Q9RJH8|SCF73.09 putative integral membrane protein from Streptomyces coelicolor (370 aa) FASTA scores: opt: 439%2C E(): 3.9e-20%2C (50.2%25 identity in 384 aa overlap)%3B Q9PE36|XF1192 integral membrane protein from Xylella fastidiosa (341 aa)%2C FASTA scores: opt: 337%2C E(): 8.3e-14%2C(47.65%25 identity in 361 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3629c;product=Probable conserved integral membrane protein;protein_id=CCP46452.1;transl_table=11
AL123456.3	EMBL	gene	4069175	4070470	.	+	.	ID=gene-Rv3630;Name=Rv3630;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3630
AL123456.3	EMBL	CDS	4069175	4070470	.	+	0	ID=cds-CCP46453.1;Parent=gene-Rv3630;Dbxref=EnsemblGenomes-Gn:Rv3630,EnsemblGenomes-Tr:CCP46453,GOA:P9WKX9,NCBI_GP:CCP46453.1;Name=CCP46453.1;Note=Rv3630%2C (MTCY15C10.22c)%2C len: 431 aa. Probable conserved integral membrane%2C highly similar to P71789|YF10_MYCTU|Rv1510|MTCY277.32 hypothetical 44.3 KDA protein from Mycobacterium tuberculosis (432 aa) FASTA scores: opt: 1940%2C E(): 2.3e-103%2C (70.75%25 identity in 424 aa overlap). Note that N-terminal end is highly similar to AAK45825|MT1558 hypothetical 18.1 KDA protein from Mycobacterium tuberculosis strain CDC1551 (172 aa) FASTA scores: opt: 649%2C E(): 4.2e-30%2C (61.65%25 identity in 167 aa overlap)%3B and C-terminal end is highly similar to AAK45826|MT1560 hypothetical 25.8 KDA protein from Mycobacterium tuberculosis strain CDC1551 (256 aa)%2C FASTA scores: opt: 1269%2C E(): 2.6e-65%2C (76.7%25 identity in 253 aa overlap). Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site%2C so could be a protease.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00639;locus_tag=Rv3630;product=Probable conserved integral membrane protein;protein_id=CCP46453.1;transl_table=11
AL123456.3	EMBL	gene	4070514	4071239	.	+	.	ID=gene-Rv3631;Name=Rv3631;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3631
AL123456.3	EMBL	CDS	4070514	4071239	.	+	0	ID=cds-CCP46454.1;Parent=gene-Rv3631;Dbxref=EnsemblGenomes-Gn:Rv3631,EnsemblGenomes-Tr:CCP46454,GOA:O06376,InterPro:IPR001173,InterPro:IPR029044,UniProtKB/TrEMBL:O06376,NCBI_GP:CCP46454.1;Name=CCP46454.1;Note=Rv3631%2C (MTCY15C10.21c)%2C len: 241 aa. Possible transferase%2C more specifically a glycosyltransferase %2Cequivalent to O69542|MLCB2548.24c|ML0207 putative transferase (putative glycosyltransferase) from Mycobacterium leprae (239 aa) FASTA scores: opt: 1303%2C E(): 2.8e-72%2C (81.2%25 identity in 239 aa overlap). Also similar to many dolichyl-phosphate mannose synthases and hypothetical proteins e.g. O59263|PH1585 hypothetical 34.6 KDA protein from Pyrococcus horikoshii (313 aa)%2C FASTA scores: opt: 472%2C E(): 1.2e-21%2C (36.65%25 identity in 232 aa overlap)%3B Q9V152|PAB1971 dolichyl-phosphate mannose synthase from Pyrococcus abyssi (287 aa)%2C FASTA scores: opt: 467%2C E(): 2.3e-21%2C (35.85%25 identity in 223 aa overlap)%3B Q58619|YC22_METJA|MJ1222 hypothetical protein from Methanococcus jannaschii (243 aa)%2C FASTA scores: opt: 400%2C E(): 2.4e-17%2C (33.35%25 identity in 228 aa overlap)%3B O26474|MTH374 dolichyl-phosphate mannose synthase related protein from Methanobacterium thermoautotrophicum (291 aa) FASTA scores: opt: 354%2C E(): 1.7e-14%2C (33.5%25 identity in 218 aa overlap)%3B O26239|MTH136 dolichyl-phosphate mannose synthase from Methanobacterium thermoautotrophicum (220 aa)%2C FASTA scores: opt: 345%2C E(): 4.8e-14%2C (33.5%25 identity in 221 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3631;product=Possible transferase (possibly glycosyltransferase);protein_id=CCP46454.1;transl_table=11
AL123456.3	EMBL	gene	4071236	4071580	.	+	.	ID=gene-Rv3632;Name=Rv3632;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3632
AL123456.3	EMBL	CDS	4071236	4071580	.	+	0	ID=cds-CCP46455.1;Parent=gene-Rv3632;Dbxref=EnsemblGenomes-Gn:Rv3632,EnsemblGenomes-Tr:CCP46455,InterPro:IPR019277,UniProtKB/TrEMBL:I6YGT7,NCBI_GP:CCP46455.1;Name=CCP46455.1;Note=Rv3632%2C (MTCY15C10.20c)%2C len: 114 aa. Possible conserved membrane protein%2C equivalent to O69541|MLCB2548.23c|ML0208 hypothetical 12.9 KDA protein (putative membrane protein) from Mycobacterium leprae (113 aa)%2C FASTA scores: opt: 594%2C E(): 7.1e-35%2C (82.0%25 identity in 111 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3632;product=Possible conserved membrane protein;protein_id=CCP46455.1;transl_table=11
AL123456.3	EMBL	gene	4071791	4072666	.	+	.	ID=gene-Rv3633;Name=Rv3633;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3633
AL123456.3	EMBL	CDS	4071791	4072666	.	+	0	ID=cds-CCP46456.1;Parent=gene-Rv3633;Dbxref=EnsemblGenomes-Gn:Rv3633,EnsemblGenomes-Tr:CCP46456,GOA:P9WI89,InterPro:IPR008775,NCBI_GP:CCP46456.1;Name=CCP46456.1;Note=Rv3633%2C (MTCY15C10.19c)%2C len: 291 aa. Conserved protein%2C similar to Q9X5S6|MMCH from Streptomyces lavendulae (254 aa)%2C FASTA scores: opt: 368%2C E(): 3.2e-16%2C(35.05%25 identity in 194 aa overlap)%3B Q9APW1 hypothetical 32.7 KDA protein from Pseudomonas aeruginosa (295 aa)%2CFASTA scores: opt: 359%2C E(): 1.3e-15%2C (37.65%25 identity in 170 aa overlap)%3B Q9APV4 hypothetical 34.1 KDA protein from Pseudomonas aeruginosa (309 aa)%2C FASTA scores: opt: 316%2CE(): 7.6e-13%2C (28.65%25 identity in 262 aa overlap). And some similarity to Q9HGD7|FUM9 FUM9P from Gibberella moniliformis (300 aa)%2C FASTA scores: opt: 254%2C E(): 6.5e-09%2C (29.95%25 identity in 157 aa overlap)%3B and P47181|YJ9S_YEAST|YJR154W|J2240 hypothetical 39.0 KDA protein from Saccharomyces cerevisiae (Baker's yeast) (346 aa)%2C FASTA scores: opt: 190%2C E(): 8.5e-05%2C (26.75%25 identity in 127 aa overlap). Also similar to P71782|YF01_MYCTU|Rv1501|MT1550|MTCY277.23 from Mycobacterium tuberculosis (273 aa)%2C FASTA scores: opt: 286%2C E(): 5.5e-11%2C (27.5%25 identity in 280 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3633;product=Conserved protein;protein_id=CCP46456.1;transl_table=11
AL123456.3	EMBL	gene	4072667	4073611	.	-	.	ID=gene-Rv3634c;Name=galE1;gbkey=Gene;gene=galE1;gene_biotype=protein_coding;gene_synonym=rmlB2;locus_tag=Rv3634c
AL123456.3	EMBL	CDS	4072667	4073611	.	-	0	ID=cds-CCP46457.1;Parent=gene-Rv3634c;Dbxref=EnsemblGenomes-Gn:Rv3634c,EnsemblGenomes-Tr:CCP46457,GOA:P9WN67,InterPro:IPR001509,InterPro:IPR016040,NCBI_GP:CCP46457.1;Name=CCP46457.1;Note=Rv3634c%2C (MTCY15C10.18)%2C len: 314 aa. GalE1%2CUDP-glucose 4-epimerase (see citations below)%2C equivalent to O69544|ML0204|RMLB2|MLCB2548.27c putative sugar dehydratase (putative sugar-nucleotide dehydratase) from Mycobacterium leprae (319 aa)%2C FASTA scores: opt: 1798%2CE(): 8.2e-100%2C (86.4%25 identity in 309 aa overlap). Also similar to other UDP-glucose 4-epimerases e.g. Q9WYX9|TM0509 from Thermotoga maritima (309 aa) FASTA scores: opt: 877%2C E(): 4.8e-45%2C (45.8%25 identity in 308 aa overlap)%3B Q57664|GALE_METJA|MJ0211 from Methanococcus jannaschii (305 aa)%2C FASTA scores: opt: 792%2C E(): 5.4e-40%2C(42.05%25 identity in 309 aa overlap)%3B Q9K6S7|BH3649 from Bacillus halodurans (311 aa)%2C FASTA scores: opt: 723%2C E(): 7e-36%2C (40.5%25 identity in 316 aa overlap)%3B Q9HSV1|GALE2|VNG0063G from Halobacterium sp. strain NRC-1 (328 aa)%2C FASTA scores: opt: 597%2C E(): 2.3e-28%2C (36.35%25 identity in 322 aa overlap)%3B etc. Contains short-chain alcohol dehydrogenase family signature (PS00061) but this maynot be significant. Belongs to the sugar epimerase family. Note that previously known as rmlB2%2C a dTDP-glucose 4%2C6-dehydratase (see Ma et al.%2C 2001).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=galE1;locus_tag=Rv3634c;product=UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase);protein_id=CCP46457.1;transl_table=11
AL123456.3	EMBL	gene	4073634	4075409	.	+	.	ID=gene-Rv3635;Name=Rv3635;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3635
AL123456.3	EMBL	CDS	4073634	4075409	.	+	0	ID=cds-CCP46458.1;Parent=gene-Rv3635;Dbxref=EnsemblGenomes-Gn:Rv3635,EnsemblGenomes-Tr:CCP46458,GOA:I6Y460,UniProtKB/TrEMBL:I6Y460,NCBI_GP:CCP46458.1;Name=CCP46458.1;Note=Rv3635%2C (MTCY15C10.17c)%2C len: 591 aa (start unclear). Probable conserved transmembrane protein%2Cequivalent%2C but longer 25 aa%2C to O69545|ML0203|MLCB2548.28 putative membrane protein from Mycobacterium leprae (569 aa)%2C FASTA scores: opt: 2933%2C E(): 4.6e-173%2C (77.0%25 identity in 569 aa overlap).;gbkey=CDS;locus_tag=Rv3635;product=Probable conserved transmembrane protein;protein_id=CCP46458.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	4075615	4077750	.	+	.	ID=id-AL123456.3:4075615..4077750;Note=IS1534%2C len: 2136 nt. Putative Insertion sequence element%2C IS1534 (IS15C10.2)%2C that resembles IS21%3B possibly defective.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1534
AL123456.3	EMBL	repeat_region	4075615	4075630	.	+	.	ID=id-AL123456.3:4075615..4075630;Note=16 bp inverted repeat at the left end of putative IS element IS1534%3B GAAAATTGACCAGCTT.;gbkey=repeat_region
AL123456.3	EMBL	gene	4075752	4076099	.	+	.	ID=gene-Rv3636;Name=Rv3636;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3636
AL123456.3	EMBL	CDS	4075752	4076099	.	+	0	ID=cds-CCP46459.1;Parent=gene-Rv3636;Dbxref=EnsemblGenomes-Gn:Rv3636,EnsemblGenomes-Tr:CCP46459,GOA:O06371,InterPro:IPR011991,InterPro:IPR013249,UniProtKB/TrEMBL:O06371,NCBI_GP:CCP46459.1;Name=CCP46459.1;Note=Rv3636%2C (MTCY15C10.16c)%2C len: 115 aa. Possible transposase%2C weakly similar to others e.g. O69924|SC3C8.12 putative transposase from Streptomyces coelicolor (487 aa) FASTA scores: opt: 132%2C E(): 0.12%2C (33.05%25 identity in 112 aa overlap)%3B O96916 TC1-like transposase from Anopheles gambiae (African malaria mosquito) (332 aa)%2C FASTA scores: opt: 117%2C E(): 0.84%2C (30.75%25 identity in 91 aa overlap)%3B Q9R2U5|IS466A|IS466A-ORF|TNPA|IS469|SCP1.276 transposase (insertion element IS466S transposase) from Streptomyces coelicolor (513 aa)%2C FASTA scores: opt: 114%2C E(): 2%2C (30.5%25 identity in 82 aa overlap)%3B etc. Similar in part to P96288|Rv2943|MTCY24G1.06c hypothetical 45.8 KDA protein from Mycobacterium tuberculosis (413 aa)%2C FASTA scores: opt: 533%2C E(): 1.4e-28%2C (74.55%25 identity in 110 aa overlap). Contains possible helix-turn-helix motif from aa 19-40 (+4.98 SD).;gbkey=CDS;locus_tag=Rv3636;product=Possible transposase;protein_id=CCP46459.1;transl_table=11
AL123456.3	EMBL	gene	4076484	4076984	.	+	.	ID=gene-Rv3637;Name=Rv3637;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3637
AL123456.3	EMBL	CDS	4076484	4076984	.	+	0	ID=cds-CCP46460.1;Parent=gene-Rv3637;Dbxref=EnsemblGenomes-Gn:Rv3637,EnsemblGenomes-Tr:CCP46460,UniProtKB/TrEMBL:O06370,NCBI_GP:CCP46460.1;Name=CCP46460.1;Note=Rv3637%2C (MTCY15C10.15c)%2C len: 166 aa. Possible transposase. C-terminal end highly similar to Q9RLQ9|ISTA putative transposase a (fragment) from Mycobacterium bovis (102 aa)%2C FASTA scores: opt: 397%2C E(): 1.4e-19%2C (58.8%25 identity in 102 aa overlap). Weakly similar to others e.g. Q9KJ02 putative transposase (fragment) from Polyangium cellulosum (329 aa)%2C FASTA scores: opt: 191%2C E(): 1.6e-05%2C(32.1%25 identity in 134 aa overlap)%3B Q9LCU2|ISTA cointegrase from Pseudomonas aeruginosa (382 aa) FASTA scores: opt: 144%2C E(): 0.024%2C (26.8%25 identity in 123 aa overlap)%3B P15025|ISTA_PSEAE transposase for insertion sequence element IS21 from Pseudomonas aeruginosa (390 aa)%2C FASTA scores: opt: 144%2C E(): 0.025%2C (26.85%25 identity in 123 aa overlap)%3B etc. Also highly similar to C-terminal end of P96288|Rv2943|MTCY24G1.06c hypothetical 45.8 KDA protein from Mycobacterium tuberculosis (413 aa) FASTA scores: opt: 722%2C E(): 1.5e-40%2C (63.7%25 identity in 168 aa overlap).;gbkey=CDS;locus_tag=Rv3637;product=Possible transposase;protein_id=CCP46460.1;transl_table=11
AL123456.3	EMBL	gene	4076984	4077730	.	+	.	ID=gene-Rv3638;Name=Rv3638;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3638
AL123456.3	EMBL	CDS	4076984	4077730	.	+	0	ID=cds-CCP46461.1;Parent=gene-Rv3638;Dbxref=EnsemblGenomes-Gn:Rv3638,EnsemblGenomes-Tr:CCP46461,GOA:I6XHU7,InterPro:IPR002611,InterPro:IPR027417,InterPro:IPR028350,UniProtKB/TrEMBL:I6XHU7,NCBI_GP:CCP46461.1;Name=CCP46461.1;Note=Rv3638%2C (MTCY15C10.14c)%2C len: 248 aa. Possible transposase%2C highly similar to Q9RLQ8|ISTB ISTB protein from Mycobacterium bovis (266 aa)%2C FASTA scores: opt: 784%2CE(): 4e-46%2C (78.0%25 identity in 259 aa overlap)%3B and similar to others e.g. P15026|ISTB_PSEAE insertion sequence IS21 putative ATP-binding protein from Pseudomonas aeruginosa (265 aa)%2C FASTA scores: opt: 420%2C E(): 2.2e-21%2C (38.8%25 identity in 255 aa overlap)%3B Q45619|ISTB_BACST insertion sequence IS5376 putative ATP-binding protein from Bacillus stearothermophilus (251 aa)%2C FASTA scores: opt: 402%2C E(): 3.6e-20%2C (34.5%25 identity in 232 aa overlap)%3B P15026|ISTB_ECOLI ISTB protein from Escherichia coli (265 aa)%2C FASTA scores: opt: 419%2C E(): 8e-23%2C (38.8%25 identity in 255 aa overlap)%3B etc. C-terminus highly similar to C-terminus of P96287|Rv2944|MTCY24G1.05 hypothetical 25.5 KDA protein from Mycobacterium tuberculosis strain H37Rv (alias AAK47343|MT3016 IS1533%2C ORFB from Mycobacterium tuberculosis strain CDC1551) (238 aa)%2C FASTA scores: opt: 784%2C E(): 3.6e-46%2C (87.4%25 identity in 135 aa overlap).;gbkey=CDS;locus_tag=Rv3638;product=Possible transposase;protein_id=CCP46461.1;transl_table=11
AL123456.3	EMBL	repeat_region	4077735	4077750	.	-	.	ID=id-AL123456.3:4077735..4077750;Note=16 bp inverted repeat at the right end of putative IS element IS1534%3B GAAAATTGACCAGCTT.;gbkey=repeat_region
AL123456.3	EMBL	gene	4077884	4078450	.	-	.	ID=gene-Rv3639c;Name=Rv3639c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3639c
AL123456.3	EMBL	CDS	4077884	4078450	.	-	0	ID=cds-CCP46462.1;Parent=gene-Rv3639c;Dbxref=EnsemblGenomes-Gn:Rv3639c,EnsemblGenomes-Tr:CCP46462,UniProtKB/TrEMBL:I6YGU1,NCBI_GP:CCP46462.1;Name=CCP46462.1;Note=Rv3639c%2C (MTCY15C10.13)%2C len: 188 aa. Hypothetical protein%2C with C-terminus highly similar to N-terminus of P95044|Rv0698|MTCY210.15 hypothetical 22.3 KDA protein from Mycobacterium tuberculosis (203 aa)%2C FASTA scores: opt: 224%2C E(): 4.5e-07%2C (54.8%25 identity in 73 aa overlap).;gbkey=CDS;locus_tag=Rv3639c;product=Conserved hypothetical protein;protein_id=CCP46462.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	4078506	4079798	.	-	.	ID=id-AL123456.3:4078506..4079798;Note=IS1553%2C len: 1293 nt. Putative Insertion sequence element%2C IS1553.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1553
AL123456.3	EMBL	repeat_region	4078506	4078518	.	+	.	ID=id-AL123456.3:4078506..4078518;Note=13 bp inverted repeat at the right end of putative IS element IS1553%3B GAGTTCGTCGGTG.;gbkey=repeat_region
AL123456.3	EMBL	gene	4078520	4079749	.	-	.	ID=gene-Rv3640c;Name=Rv3640c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3640c
AL123456.3	EMBL	CDS	4078520	4079749	.	-	0	ID=cds-CCP46463.1;Parent=gene-Rv3640c;Dbxref=EnsemblGenomes-Gn:Rv3640c,EnsemblGenomes-Tr:CCP46463,GOA:O06367,InterPro:IPR001207,UniProtKB/TrEMBL:O06367,NCBI_GP:CCP46463.1;Name=CCP46463.1;Note=Rv3640c%2C (MTCY15C10.12)%2C len: 409 aa. Probable transposase%2C highly similar to others e.g. Q48882 transposase from Mycobacterium avium (411 aa) FASTA scores: opt: 1574%2C E(): 6.2e-93%2C (59.75%25 identity in 400 aa overlap)%3B Q9AKV5 putative transposase (fragment) from Mycobacterium paratuberculosis (395 aa)%2C FASTA scores: opt: 1566%2C E(): 1.9e-92%2C (60.0%25 identity in 395 aa overlap)%3B Q48368 transposase from Mycobacterium avium (410 aa)%2C FASTA scores: opt: 1561%2C E(): 4.1e-92%2C (59.4%25 identity in 404 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3640c;product=Probable transposase;protein_id=CCP46463.1;transl_table=11
AL123456.3	EMBL	repeat_region	4079786	4079798	.	-	.	ID=id-AL123456.3:4079786..4079798;Note=13 bp inverted repeat at the left end of putative IS element IS1553%3B GAGATCGTCGGTG.;gbkey=repeat_region
AL123456.3	EMBL	gene	4079925	4080560	.	-	.	ID=gene-Rv3641c;Name=fic;gbkey=Gene;gene=fic;gene_biotype=protein_coding;locus_tag=Rv3641c
AL123456.3	EMBL	CDS	4079925	4080560	.	-	0	ID=cds-CCP46464.1;Parent=gene-Rv3641c;Dbxref=EnsemblGenomes-Gn:Rv3641c,EnsemblGenomes-Tr:CCP46464,InterPro:IPR003812,UniProtKB/TrEMBL:I6YCN3,NCBI_GP:CCP46464.1;Name=CCP46464.1;Note=Rv3641c%2C (MTCY15C10.11)%2C len: 211 aa. Possible fic%2Ccell filamentation protein%2C similar to others e.g. Q9PCU8|XF1657 cell filamentation protein from Xylella fastidiosa (203 aa)%2C FASTA scores: opt: 324%2C E(): 2.2e-14%2C(32.8%25 identity in 189 aa overlap)%3B P20605|FIC_ECOLI|B3361 from Escherichia coli strain K12 (200 aa)%2C FASTA scores: opt: 323%2C E(): 2.5e-14%2C (31.0%25 identity in 187 aa overlap)%3B P20751|FIC_SALTY from Salmonella typhimurium (200 aa)%2CFASTA scores: opt: 322%2C E(): 2.9e-14%2C (32.65%25 identity in 193 aa overlap)%3B etc.;gbkey=CDS;gene=fic;locus_tag=Rv3641c;product=Possible cell filamentation protein Fic;protein_id=CCP46464.1;transl_table=11
AL123456.3	EMBL	gene	4080571	4080765	.	-	.	ID=gene-Rv3642c;Name=Rv3642c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3642c
AL123456.3	EMBL	CDS	4080571	4080765	.	-	0	ID=cds-CCP46465.1;Parent=gene-Rv3642c;Dbxref=EnsemblGenomes-Gn:Rv3642c,EnsemblGenomes-Tr:CCP46465,UniProtKB/TrEMBL:I6Y464,NCBI_GP:CCP46465.1;Name=CCP46465.1;Note=Rv3642c%2C (MTCY15C10.10)%2C len: 64 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3642c;product=Hypothetical protein;protein_id=CCP46465.1;transl_table=11
AL123456.3	EMBL	gene	4081160	4081351	.	+	.	ID=gene-Rv3643;Name=Rv3643;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3643
AL123456.3	EMBL	CDS	4081160	4081351	.	+	0	ID=cds-CCP46466.1;Parent=gene-Rv3643;Dbxref=EnsemblGenomes-Gn:Rv3643,EnsemblGenomes-Tr:CCP46466,UniProtKB/TrEMBL:O06364,NCBI_GP:CCP46466.1;Name=CCP46466.1;Note=Rv3643%2C (MTCY15C10.09c)%2C len: 63 aa (questionable ORF). Identical to AAK48106 from Mycobacterium tuberculosis strain CDC1551 (33 aa) but longer 30 aa.;gbkey=CDS;locus_tag=Rv3643;product=Hypothetical protein;protein_id=CCP46466.1;transl_table=11
AL123456.3	EMBL	gene	4081365	4081437	.	-	.	ID=gene-thrU;Name=thrU;gbkey=Gene;gene=thrU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	4081365	4081437	.	-	.	ID=rna-thrU;Parent=gene-thrU;Note=codon recognized: ACG%3B thrU%2C tRNA-Thr%2C anticodon cgt%2C length %3D 73;anticodon=(pos:complement(4081402..4081404));gbkey=tRNA;gene=thrU;product=tRNA-Thr
AL123456.3	EMBL	exon	4081365	4081437	.	-	.	ID=exon-thrU-1;Parent=rna-thrU;Note=codon recognized: ACG%3B thrU%2C tRNA-Thr%2C anticodon cgt%2C length %3D 73;anticodon=(pos:complement(4081402..4081404));gbkey=tRNA;gene=thrU;product=tRNA-Thr
AL123456.3	EMBL	gene	4081516	4082721	.	-	.	ID=gene-Rv3644c;Name=Rv3644c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3644c
AL123456.3	EMBL	CDS	4081516	4082721	.	-	0	ID=cds-CCP46467.1;Parent=gene-Rv3644c;Dbxref=EnsemblGenomes-Gn:Rv3644c,EnsemblGenomes-Tr:CCP46467,GOA:O06363,InterPro:IPR003593,InterPro:IPR004622,InterPro:IPR008921,InterPro:IPR027417,UniProtKB/TrEMBL:O06363,NCBI_GP:CCP46467.1;Name=CCP46467.1;Note=Rv3644c%2C (MTCY15C10.08)%2C len: 401 aa. Possible DNA polymerase%2C equivalent to O69546|MLCB2548.29c|ML0202 hypothetical 42.7 KDA protein from Mycobacterium leprae (405 aa)%2C FASTA scores: opt: 2180%2C E(): 6.1e-116%2C (84.4%25 identity in 404 aa overlap). Similar (in totality or in first 200 aa) to DNA polymerases III%2C delta' or gamma subunit%2C e.g. Q9X906|SCH5.03c putative DNA polymerase from Streptomyces coelicolor (401 aa)%2C FASTA scores: opt: 1022%2CE(): 1.5e-50%2C (47.05%25 identity in 404 aa overlap)%3B Q9RRS5|DR2410 DNA polymerase III%2C tau/gamma subunit from Deinococcus radiodurans (615 aa)%2C FASTA scores: opt: 370%2CE(): 1.3e-13%2C (29.95%25 identity in 394 aa overlap)%3B P28631|HOLB_ECOLI|B1099 DNA polymerase III%2C delta' subunit from Escherichia coli strain K12 (334 aa)%2C FASTA scores: opt: 345%2C E(): 2.2e-12%2C (33.45%25 identity in 239 aa overlap)%3B Q9JTS1|DNAZX|NMA1656 DNA polymerase III tau and gamma chains from Neisseria meningitidis (serogroup A) (709 aa)%2C FASTA scores: opt: 346%2C E(): 3.3e-12%2C (28.55%25 identity in 364 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3644c;product=Possible DNA polymerase;protein_id=CCP46467.1;transl_table=11
AL123456.3	EMBL	gene	4082807	4084456	.	+	.	ID=gene-Rv3645;Name=Rv3645;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3645
AL123456.3	EMBL	CDS	4082807	4084456	.	+	0	ID=cds-CCP46468.1;Parent=gene-Rv3645;Dbxref=EnsemblGenomes-Gn:Rv3645,EnsemblGenomes-Tr:CCP46468,GOA:I6X7Z3,InterPro:IPR001054,InterPro:IPR003660,InterPro:IPR029787,UniProtKB/TrEMBL:I6X7Z3,NCBI_GP:CCP46468.1;Name=CCP46468.1;Note=Rv3645%2C (MTCY15C10.07c)%2C len: 549 aa. Probable conserved transmembrane protein%2C equivalent%2C but longer 20 aa%2C to O69547|ML0201|MLCB2548.30 putative membrane protein from Mycobacterium leprae (530 aa)%2C FASTA scores: opt: 2958%2C E(): 1.5e-168%2C (85.5%25 identity in 530 aa overlap). Also closely related to several other hypothetical M. tuberculosis proteins%2C e.g. Q10631|YD18_MYCTU|Rv1318c|MT1359|MTCY130.03c (541 aa) FASTA scores: opt: 1105%2C E(): 2.7e-58%2C (39.35%25 identity in 506 aa overlap)%3B Q10633|YD20_MYCTU|Rv1320c|MT1362|MTCY130.05c (567 aa) FASTA scores: opt: 1031%2C E(): 7.1e-54%2C (38.1%25 identity in 509 aa overlap)%3B Q10632|YD19_MYCTU|Rv1319c|MTCY130.04c (535 aa)%2C FASTA scores: opt: 1016%2C E(): 5.3e-53%2C (37.1%25 identity in 531 aa overlap)%3B etc. Also similar at C-terminal end to many adenylate cyclases e.g. O83498|TP0485 from Treponema pallidum (614 aa) FASTA scores: opt: 365%2C E(): 3.2e-14%2C (31.55%25 identity in 317 aa overlap)%3B P94180|CYAA from Anabaena sp. strain PCC 7120 (735 aa)%2C FASTA scores: opt: 364%2C E(): 4.2e-14%2C (32.75%25 identity in 229 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3645;product=Probable conserved transmembrane protein;protein_id=CCP46468.1;transl_table=11
AL123456.3	EMBL	gene	4084453	4087257	.	-	.	ID=gene-Rv3646c;Name=topA;gbkey=Gene;gene=topA;gene_biotype=protein_coding;locus_tag=Rv3646c
AL123456.3	EMBL	CDS	4084453	4087257	.	-	0	ID=cds-CCP46469.1;Parent=gene-Rv3646c;Dbxref=EnsemblGenomes-Gn:Rv3646c,EnsemblGenomes-Tr:CCP46469,GOA:P9WG49,InterPro:IPR000380,InterPro:IPR003601,InterPro:IPR003602,InterPro:IPR005733,InterPro:IPR006171,InterPro:IPR013497,InterPro:IPR013824,InterPro:IPR013825,InterPro:IPR023405,InterPro:IPR023406,InterPro:IPR025589,InterPro:IPR028612,NCBI_GP:CCP46469.1;Name=CCP46469.1;Note=Rv3646c%2C (MTCY15C10.06)%2C len: 934 aa. TopA%2C DNA topoisomerase I (see citations below)%2C equivalent to O69548|TOP1_MYCLE|TOPA|ML0200|MLCB2548.31c DNA topoisomerase I from Mycobacterium leprae (947 aa) FASTA scores: opt: 5150%2C E(): 0%2C (84.6%25 identity in 936 aa overlap). Also highly similar to many e.g. Q9X909|TOP1_STRCO|TOPA|SCH5.06c from Streptomyces coelicolor (952 aa)%2C FASTA scores: opt: 2754%2C E(): 1.3e-153%2C (61.3%25 identity in 928 aa overlap)%3B P73810|TOP1_SYNY3|TOPA|SLR2058 from Synechocystis sp. strain PCC 6803 (898 aa)%2C FASTA scores: opt: 1442%2C E(): 9.1e-77%2C (47.15%25 identity in 927 aa overlap)%3B P47368|TOP1_MYCGE|TOPA|MG122 from Mycoplasma genitalium (709 aa)%2C FASTA scores: opt: 865%2C E(): 4.8e-43%2C (30.3%25 identity in 736 aa overlap)%3B P06612|TOP1_ECOLI|TOPA|SUPX|B1274 from Escherichia coli strain K12 (865 aa)%2C FASTA scores: opt: 397%2C E(): 0%2C (39.6%25 identity in 704 aa overlap)%3B etc. Belongs to prokaryotic type I/III topoisomerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=topA;inference=protein motif:PROSITE:PS00396;locus_tag=Rv3646c;product=DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (TOPO I);protein_id=CCP46469.1;transl_table=11
AL123456.3	EMBL	gene	4087610	4088188	.	-	.	ID=gene-Rv3647c;Name=Rv3647c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3647c
AL123456.3	EMBL	CDS	4087610	4088188	.	-	0	ID=cds-CCP46470.1;Parent=gene-Rv3647c;Dbxref=EnsemblGenomes-Gn:Rv3647c,EnsemblGenomes-Tr:CCP46470,UniProtKB/TrEMBL:I6Y469,NCBI_GP:CCP46470.1;Name=CCP46470.1;Note=Rv3647c%2C (MTCY15C10.05)%2C len: 192 aa. Conserved hpothetical protein%2C equivalent to O69549|MLCB2548.32c|ML0199 conserved hypothetical protein from Mycobacterium leprae (200 aa)%2C FASTA scores: opt: 1029%2C E(): 9e-58%2C (80.4%25 identity in 199 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3647c;product=Conserved hypothetical protein;protein_id=CCP46470.1;transl_table=11
AL123456.3	EMBL	gene	4088328	4088531	.	-	.	ID=gene-Rv3648c;Name=cspA;gbkey=Gene;gene=cspA;gene_biotype=protein_coding;locus_tag=Rv3648c
AL123456.3	EMBL	CDS	4088328	4088531	.	-	0	ID=cds-CCP46471.1;Parent=gene-Rv3648c;Dbxref=EnsemblGenomes-Gn:Rv3648c,EnsemblGenomes-Tr:CCP46471,GOA:P9WP75,InterPro:IPR002059,InterPro:IPR011129,InterPro:IPR012156,InterPro:IPR012340,InterPro:IPR019844,NCBI_GP:CCP46471.1;Name=CCP46471.1;Note=Rv3648c%2C (MTCY15C10.04)%2C len: 67 aa. Probable cspA%2Ccold shock protein A%2C identical to O69550|CSPB|CSPA|ML0198 small cold-shock protein from Mycobacterium leprae (67 aa) FASTA scores: opt: 451%2C E(): 3.7e-27%2C (97.0%25 identity in 67 aa overlap). Also highly similar to many e.g. Q9KGW0|CSPA from Mycobacterium smegmatis (67 aa) FASTA scores: opt: 439%2C E(): 2.9e-26%2C (92.55%25 identity in 67 aa overlap)%3B P54584|CSP_ARTGO from Arthrobacter globiformis (67 aa)%2CFASTA scores: opt: 335%2C E(): 1.5e-18%2C (73.45%25 identity in 64 aa overlap)%3B O30875|CSPA_MICLU from Micrococcus luteus (Micrococcus lysodeikticus)%3B Q9Z5R4|CSPA_BORPE from Bordetella pertussis (67 aa) FASTA scores: opt: 294%2C E(): 1.7e-15%2C (59.7%25 identity in 67 aa overlap)%3B etc. Contains 'cold-shock' DNA-binding domain signature (PS00352) at N-terminal end. Belongs to the cold-shock domain (CSD) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cspA;inference=protein motif:PROSITE:PS00352;locus_tag=Rv3648c;product=Probable cold shock protein A CspA;protein_id=CCP46471.1;transl_table=11
AL123456.3	EMBL	gene	4088781	4091096	.	+	.	ID=gene-Rv3649;Name=Rv3649;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3649
AL123456.3	EMBL	CDS	4088781	4091096	.	+	0	ID=cds-CCP46472.1;Parent=gene-Rv3649;Dbxref=EnsemblGenomes-Gn:Rv3649,EnsemblGenomes-Tr:CCP46472,GOA:O06359,InterPro:IPR001650,InterPro:IPR011545,InterPro:IPR014001,InterPro:IPR018973,InterPro:IPR022307,InterPro:IPR027417,UniProtKB/TrEMBL:O06359,NCBI_GP:CCP46472.1;Name=CCP46472.1;Note=Rv3649%2C (MTCY15C10.03c)%2C len: 771 aa. Probable helicase%2C similar to many (known or hypothetical) ATP-dependent helicases e.g. Q9X915|SCH5.13 putative helicase from Streptomyces coelicolor (815 aa) FASTA scores: opt: 2550%2C E(): 9.6e-139%2C (52.45%25 identity in 774 aa overlap)%3B Q05549|YDR291W|D9819.1 protein similar to several DNA helicases from Saccharomyces cerevisiae (Baker's yeast) (1077 aa)%2C FASTA scores: opt: 1161%2C E(): 5.9e-59%2C (31.05%25 identity in 780 aa overlap)%3B P50830|YPRA_BACSU hypothetical helicase from Bacillus subtilis (749 aa)%2C FASTA scores: opt: 1154%2C E(): 1.1e-58%2C(34.05%25 identity in 734 aa overlap)%3B Q9KC10|BH1764 ATP-dependent RNA helicase from Bacillus halodurans (764 aa)%2C FASTA scores: opt: 1122%2C E(): 8e-57%2C (32.3%25 identity in 759 aa overlap)%3B etc. Seems similar to dead/DEAH box helicase family%2C and to helicase C-terminal domain.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3649;product=Probable helicase;protein_id=CCP46472.1;transl_table=11
AL123456.3	EMBL	gene	4091233	4091517	.	+	.	ID=gene-Rv3650;Name=PE33;gbkey=Gene;gene=PE33;gene_biotype=protein_coding;locus_tag=Rv3650
AL123456.3	EMBL	CDS	4091233	4091517	.	+	0	ID=cds-CCP46473.1;Parent=gene-Rv3650;Dbxref=EnsemblGenomes-Gn:Rv3650,EnsemblGenomes-Tr:CCP46473,InterPro:IPR000084,UniProtKB/TrEMBL:I6X7Z8,NCBI_GP:CCP46473.1;Name=CCP46473.1;Note=Rv3650%2C (MTCY15C10.02c)%2C len: 94 aa. PE33%2C Short protein%2C member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu%2C 2002)%2C but without the repetitive gly-rich region%2C similar to the N-terminal part of many e.g. O53809|Rv0746|MTV041.20 PGRS-family protein (783 aa)%2CFASTA scores: opt: 363%2C E(): 2.1e-15%2C (76.55%25 identity in 81 aa overlap).;gbkey=CDS;gene=PE33;locus_tag=Rv3650;product=PE family protein PE33;protein_id=CCP46473.1;transl_table=11
AL123456.3	EMBL	gene	4091841	4092878	.	+	.	ID=gene-Rv3651;Name=Rv3651;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3651
AL123456.3	EMBL	CDS	4091841	4092878	.	+	0	ID=cds-CCP46474.1;Parent=gene-Rv3651;Dbxref=EnsemblGenomes-Gn:Rv3651,EnsemblGenomes-Tr:CCP46474,PDB:4Q6U,UniProtKB/TrEMBL:I6YCP0,NCBI_GP:CCP46474.1;Name=CCP46474.1;Note=Rv3651%2C (MTCY15C10.01c)%2C len: 345 aa. Hypothetical protein%2C with some similarity to Q9ZHK1 hypothetical 36.5 KDA protein from Rhodococcus sp. X309 (329 aa) FASTA scores: opt: 332%2C E(): 3.4e-13%2C (27.4%25 identity in 321 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3651;product=Conserved hypothetical protein;protein_id=CCP46474.1;transl_table=11
AL123456.3	EMBL	gene	4093468	4093522	.	+	.	ID=gene-mpr18;Name=mpr18;gbkey=Gene;gene=mpr18;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	4093468	4093522	.	+	.	ID=rna-mpr18;Parent=gene-mpr18;Note=mpr18%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C 82 and 100 nt bands detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr18;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	4093468	4093522	.	+	.	ID=exon-mpr18-1;Parent=rna-mpr18;Note=mpr18%2C fragment of putative small regulatory RNA (See DiChiara et al.%2C 2010)%2C ends not mapped%2C 82 and 100 nt bands detected by Northern blot in M. bovis BCG Pasteur.;gbkey=ncRNA;gene=mpr18;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	4093632	4093946	.	+	.	ID=gene-Rv3652;Name=PE_PGRS60;gbkey=Gene;gene=PE_PGRS60;gene_biotype=protein_coding;locus_tag=Rv3652
AL123456.3	EMBL	CDS	4093632	4093946	.	+	0	ID=cds-CCP46475.1;Parent=gene-Rv3652;Dbxref=EnsemblGenomes-Gn:Rv3652,EnsemblGenomes-Tr:CCP46475,InterPro:IPR000084,UniProtKB/TrEMBL:Q6MWV1,NCBI_GP:CCP46475.1;Name=CCP46475.1;Note=Rv3652%2C (MTV025.001A)%2C len: 104 aa. PE_PGRS60%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C2002)%2C similar at N-terminal end with many e.g. P56877|Y278_MYCTU|Rv0278c|MTV035.06c (957 aa) FASTA scores: opt: 242%2C E(): 3e-09%2C (77.35%25 identity in 53 aa overlap). Originally annotated as the first part of a PE-PGRS family protein (Rv3653/PE_PGRS61 being the second part) but more similar to a PE family protein. Length extended since first submission (+50 aa).;gbkey=CDS;gene=PE_PGRS60;locus_tag=Rv3652;product=PE-PGRS family-related protein PE_PGRS60;protein_id=CCP46475.1;transl_table=11
AL123456.3	EMBL	gene	4093940	4094527	.	+	.	ID=gene-Rv3653;Name=PE_PGRS61;gbkey=Gene;gene=PE_PGRS61;gene_biotype=protein_coding;locus_tag=Rv3653
AL123456.3	EMBL	CDS	4093940	4094527	.	+	0	ID=cds-CCP46476.1;Parent=gene-Rv3653;Dbxref=EnsemblGenomes-Gn:Rv3653,EnsemblGenomes-Tr:CCP46476,UniProtKB/TrEMBL:Q6MWV0,NCBI_GP:CCP46476.1;Name=CCP46476.1;Note=Rv3653%2C (MTV025.001B)%2C len: 195 aa. PE_PGRS61%2CMember of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see Brennan and Delogu%2C2002)%2C highly similar to the C-termini of members of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins%2C e.g. MTCY1A11_25%2C MTCY28_25%2C MTCY130_10%2CMTCY1A10_19%2C MTCY21B4_13%2C MTCI418B_6%2CMTCY28_34%2C MTV004_1%2CMTCY441_4%3B etc. Originally annotated as the second part of a PE-PGRS family protein (Rv3652/PE_PGRS60 being the first part). Start shortened since first submission (-50 aa).;gbkey=CDS;gene=PE_PGRS61;locus_tag=Rv3653;product=PE-PGRS family-related protein PE_PGRS61;protein_id=CCP46476.1;transl_table=11
AL123456.3	EMBL	gene	4094660	4094914	.	-	.	ID=gene-Rv3654c;Name=Rv3654c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3654c
AL123456.3	EMBL	CDS	4094660	4094914	.	-	0	ID=cds-CCP46477.1;Parent=gene-Rv3654c;Dbxref=EnsemblGenomes-Gn:Rv3654c,EnsemblGenomes-Tr:CCP46477,GOA:O69622,InterPro:IPR021202,UniProtKB/TrEMBL:O69622,NCBI_GP:CCP46477.1;Name=CCP46477.1;Note=Rv3654c%2C (MTV025.002c)%2C len: 84 aa. Hypothetical protein%2C similar to C-terminus of Q9X916|SCH5.14c membrane spanning protein from Streptomyces coelicolor (230 aa) FASTA scores: opt: 176%2C E(): 2.4e-05%2C (47.0%25 identity in 83 aa overlap). Equivalent to AAK48118 from Mycobacterium tuberculosis strain CDC1551 but shorter 18 aa.;gbkey=CDS;locus_tag=Rv3654c;product=Conserved hypothetical protein;protein_id=CCP46477.1;transl_table=11
AL123456.3	EMBL	gene	4094923	4095300	.	-	.	ID=gene-Rv3655c;Name=Rv3655c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3655c
AL123456.3	EMBL	CDS	4094923	4095300	.	-	0	ID=cds-CCP46478.1;Parent=gene-Rv3655c;Dbxref=EnsemblGenomes-Gn:Rv3655c,EnsemblGenomes-Tr:CCP46478,GOA:O69623,UniProtKB/TrEMBL:O69623,NCBI_GP:CCP46478.1;Name=CCP46478.1;Note=Rv3655c%2C (MTV025.003c)%2C len: 125 aa. Hypothetical protein%2C with similarity to Q9X917|SCH5.15c hypothetical 15.2 KDA protein from Streptomyces coelicolor (150 aa) FASTA scores: opt: 211%2C E(): 7.7e-07%2C (39.65%25 identity in 111 aa overlap). Equivalent to AAK48119 from Mycobacterium tuberculosis strain CDC1551 (99 aa) but longer 26 aa at the C-terminus.;gbkey=CDS;locus_tag=Rv3655c;product=Conserved hypothetical protein;protein_id=CCP46478.1;transl_table=11
AL123456.3	EMBL	gene	4095324	4095530	.	-	.	ID=gene-Rv3656c;Name=Rv3656c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3656c
AL123456.3	EMBL	CDS	4095324	4095530	.	-	0	ID=cds-CCP46479.1;Parent=gene-Rv3656c;Dbxref=EnsemblGenomes-Gn:Rv3656c,EnsemblGenomes-Tr:CCP46479,InterPro:IPR025338,UniProtKB/TrEMBL:O69624,NCBI_GP:CCP46479.1;Name=CCP46479.1;Note=Rv3656c%2C (MTV025.004c)%2C len: 68 aa. Conserved hypothetical protein%2C similar to Q9X918|SCH5.16c small hypothetical protein from Streptomyces coelicolor (75 aa)%2CFASTA scores: opt: 129%2C E(): 0.0039%2C (40.0%25 identity in 60 aa overlap). Equivalent to AAK48120 from Mycobacterium tuberculosis strain CDC1551 (42 aa) but longer 26 aa.;gbkey=CDS;locus_tag=Rv3656c;product=Conserved hypothetical protein;protein_id=CCP46479.1;transl_table=11
AL123456.3	EMBL	gene	4095540	4096115	.	-	.	ID=gene-Rv3657c;Name=Rv3657c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3657c
AL123456.3	EMBL	CDS	4095540	4096115	.	-	0	ID=cds-CCP46480.1;Parent=gene-Rv3657c;Dbxref=EnsemblGenomes-Gn:Rv3657c,EnsemblGenomes-Tr:CCP46480,InterPro:IPR018076,UniProtKB/TrEMBL:O69625,NCBI_GP:CCP46480.1;Name=CCP46480.1;Note=Rv3657c%2C (MTV025.005c)%2C len: 191 aa. Possible conserved membrane protein%2C rich in ala residues%2C similar to Q9X919|SCH5.17c putative integral membrane protein from Streptomyces coelicolor (267 aa)%2C FASTA scores: opt: 324%2CE(): 4.7e-12%2C (40.9%25 identity in 154 aa overlap).;gbkey=CDS;locus_tag=Rv3657c;product=Possible conserved alanine rich membrane protein;protein_id=CCP46480.1;transl_table=11
AL123456.3	EMBL	gene	4096139	4096939	.	-	.	ID=gene-Rv3658c;Name=Rv3658c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3658c
AL123456.3	EMBL	CDS	4096139	4096939	.	-	0	ID=cds-CCP46481.1;Parent=gene-Rv3658c;Dbxref=EnsemblGenomes-Gn:Rv3658c,EnsemblGenomes-Tr:CCP46481,GOA:I6Y479,InterPro:IPR018076,UniProtKB/TrEMBL:I6Y479,NCBI_GP:CCP46481.1;Name=CCP46481.1;Note=Rv3658c%2C (MTV025.006c)%2C len: 266 aa. Probable conserved transmembrane protein%2C similar to Q9X920|SCH5.18c putative integral membrane protein from Streptomyces coelicolor (321 aa)%2C FASTA scores: opt: 335%2C E(): 4.1e-13%2C(38.05%25 identity in 247 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3658c;product=Probable conserved transmembrane protein;protein_id=CCP46481.1;transl_table=11
AL123456.3	EMBL	gene	4096936	4097994	.	-	.	ID=gene-Rv3659c;Name=Rv3659c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3659c
AL123456.3	EMBL	CDS	4096936	4097994	.	-	0	ID=cds-CCP46482.1;Parent=gene-Rv3659c;Dbxref=EnsemblGenomes-Gn:Rv3659c,EnsemblGenomes-Tr:CCP46482,GOA:P9WMT3,InterPro:IPR001482,InterPro:IPR022399,InterPro:IPR027417,NCBI_GP:CCP46482.1;Name=CCP46482.1;Note=Rv3659c%2C (MTV025.007c)%2C len: 352 aa. Conserved hypothetical protein%2C highly similar%2C but always shorter (various lengths) at N-terminus%2C to Q9X921|SCH5.19c putative secretory protein from Streptomyces coelicolor (523 aa)%2C FASTA scores: opt: 1287%2C E(): 5.3e-66%2C (59.85%25 identity in 351 aa overlap)%3B Q9HW98|PA4302 probable type II secretion system protein from Pseudomonas aeruginosa (421 aa)%2C FASTA scores: opt: 776%2C E(): 5.4e-37%2C (42.8%25 identity in 320 aa overlap)%3B AAK65510|CPAF2 probable CPAF2 PILUS assembly protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (497 aa) FASTA scores: opt: 769%2CE(): 1.5e-36%2C (40.45%25 identity in 309 aa overlap)%3B Q9KY93|SCK15.11 putative secretory protein from Streptomyces coelicolor (445 aa)%2C FASTA scores: opt: 751%2CE(): 1.5e-35%2C (38.15%25 identity in 333 aa overlap)%3B etc. Contains PS00017 ATP/GTP binding site motif A (P-loop). Note that previously known as trbB.;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3659c;product=Conserved hypothetical protein;protein_id=CCP46482.1;transl_table=11
AL123456.3	EMBL	gene	4098096	4099148	.	-	.	ID=gene-Rv3660c;Name=Rv3660c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3660c
AL123456.3	EMBL	CDS	4098096	4099148	.	-	0	ID=cds-CCP46483.1;Parent=gene-Rv3660c;Dbxref=EnsemblGenomes-Gn:Rv3660c,EnsemblGenomes-Tr:CCP46483,GOA:P9WKX7,InterPro:IPR022521,InterPro:IPR025501,InterPro:IPR027417,NCBI_GP:CCP46483.1;Name=CCP46483.1;Note=Rv3660c%2C (MTV025.008c)%2C len: 350 aa. Conserved hypothetical protein%2C similar to O33612 protein concerned in inhibition of morphological differentiation in Streptomyces azureus from Streptomyces cyaneus (Streptomyces curacoi) (370 aa)%2C FASTA scores: opt: 655%2CE(): 5.9e-31%2C (42.2%25 identity in 315 aa overlap)%3B Q9X922|SCH5.20c putative septum site determining protein from Streptomyces coelicolor (396 aa)%2C FASTA scores: opt: 592%2C E(): 2.9e-27%2C (43.25%25 identity in 275 aa overlap). And shows some similarity to AAK65513|CPAE2 probable CPAE2 PILUS assembly protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (586 aa) FASTA scores: opt: 212%2C E(): 5.1e-05%2C (25.75%25 identity in 295 aa overlap)%3B and several cell division inhibitors or septum site-determining proteins. Equivalent to AAK48124 from Mycobacterium tuberculosis strain CDC1551 (261 aa) but longer 89 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3660c;product=Conserved hypothetical protein;protein_id=CCP46483.1;transl_table=11
AL123456.3	EMBL	gene	4099386	4099478	.	-	.	ID=gene-B11;Name=B11;gbkey=Gene;gene=B11;gene_biotype=ncRNA;gene_synonym=mpr19
AL123456.3	EMBL	ncRNA	4099386	4099478	.	-	.	ID=rna-B11;Parent=gene-B11;Note=B11%2C putative small regulatory RNA (See Arnvig and Young%2C 2009%3B DiChiara et al.%2C 2010).;gbkey=ncRNA;gene=B11;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	4099386	4099478	.	-	.	ID=exon-B11-1;Parent=rna-B11;Note=B11%2C putative small regulatory RNA (See Arnvig and Young%2C 2009%3B DiChiara et al.%2C 2010).;gbkey=ncRNA;gene=B11;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	4099647	4100510	.	+	.	ID=gene-Rv3661;Name=Rv3661;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3661
AL123456.3	EMBL	CDS	4099647	4100510	.	+	0	ID=cds-CCP46484.1;Parent=gene-Rv3661;Dbxref=EnsemblGenomes-Gn:Rv3661,EnsemblGenomes-Tr:CCP46484,GOA:P9WGJ1,InterPro:IPR006383,InterPro:IPR006385,InterPro:IPR023214,NCBI_GP:CCP46484.1;Name=CCP46484.1;Note=Rv3661%2C (MTV025.009)%2C len: 287 aa. Conserved hypothetical protein%2C highly similar to O33611|IMD_STRCN from Streptomyces cyaneus (Streptomyces curacoi) protein involved in inhibition of morphological differentiation in Streptomyces azureus (belongs to the SerB family) (277 aa) FASTA scores: opt: 1073%2C E(): 3.5e-61%2C (61.45%25 identity in 262 aa overlap)%3B and Q9X923|SCH5.21 putative morphological differentiation-associated protein from Streptomyces coelicolor (268 aa)%2C FASTA scores: opt: 1057%2C E(): 3.6e-60%2C(61.45%25 identity in 262 aa overlap). Also similar to various bacterial proteins (principally serB-related proteins) e.g. Q49823|ML2424 hypothetical SERB protein from Mycobacterium leprae (300 aa)%2C FASTA scores: opt: 452%2C E(): 1.4e-21%2C (35.8%25 identity in 257 aa overlap)%3B Q9WX12|SCE68.20 hypothetical 32.0 KDA protein from Streptomyces coelicolor (298 aa)%2C FASTA scores: opt: 415%2CE(): 3.1e-19%2C (33.55%25 identity in 280 aa overlap)%3B Q9RIT2|SERB phosphoserine phosphatase (fragment) from Streptomyces coelicolor (266 aa)%2C FASTA scores: opt: 405%2CE(): 1.2e-18%2C (34.1%25 identity in 261 aa overlap)%3B etc. Also similar to Q11169|Y505_MYCTU|Rv0505c|MTCY20G9.32c hypothetical 39.5 KDA protein from Mycobacterium tuberculosis (373 aa)%2C FASTA scores: opt: 454%2C E(): 1.2e-21%2C (35.15%25 identity in 276 aa overlap). Belongs to the SerB family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3661;product=Conserved hypothetical protein;protein_id=CCP46484.1;transl_table=11
AL123456.3	EMBL	gene	4100669	4100968	.	+	.	ID=gene-MTS2823;Name=MTS2823;gbkey=Gene;gene=MTS2823;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	4100669	4100968	.	+	.	ID=rna-MTS2823;Parent=gene-MTS2823;Note=MTS2823%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C 5'-end mapped by RLM-RACE%2C 3'-end not mapped%2C ~~300 bp and ~~250 bp bands detected by Northern blot.;gbkey=ncRNA;gene=MTS2823;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	4100669	4100968	.	+	.	ID=exon-MTS2823-1;Parent=rna-MTS2823;Note=MTS2823%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C 5'-end mapped by RLM-RACE%2C 3'-end not mapped%2C ~~300 bp and ~~250 bp bands detected by Northern blot.;gbkey=ncRNA;gene=MTS2823;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	4101265	4102035	.	-	.	ID=gene-Rv3662c;Name=Rv3662c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3662c
AL123456.3	EMBL	CDS	4101265	4102035	.	-	0	ID=cds-CCP46485.1;Parent=gene-Rv3662c;Dbxref=EnsemblGenomes-Gn:Rv3662c,EnsemblGenomes-Tr:CCP46485,InterPro:IPR003812,UniProtKB/TrEMBL:I6YCP7,NCBI_GP:CCP46485.1;Name=CCP46485.1;Note=Rv3662c%2C (MTV025.010c)%2C len: 256 aa. Conserved hypothetical protein%2C equivalent to Q9CB99|ML2289 hypothetical protein from Mycobacterium leprae (256 aa) FASTA scores: opt: 1255%2C E(): 3.3e-69%2C (78.05%25 identity in 255 aa overlap). Also similar to Q9X924|SCH5.22c putative oxidoreductase from Streptomyces coelicolor (274 aa)%2C FASTA scores: opt: 289%2C E(): 1.8e-10%2C (39.25%25 identity in 270 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3662c;product=Conserved hypothetical protein;protein_id=CCP46485.1;transl_table=11
AL123456.3	EMBL	gene	4102032	4103678	.	-	.	ID=gene-Rv3663c;Name=dppD;gbkey=Gene;gene=dppD;gene_biotype=protein_coding;locus_tag=Rv3663c
AL123456.3	EMBL	CDS	4102032	4103678	.	-	0	ID=cds-CCP46486.1;Parent=gene-Rv3663c;Dbxref=EnsemblGenomes-Gn:Rv3663c,EnsemblGenomes-Tr:CCP46486,GOA:I6Y482,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR013563,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:I6Y482,NCBI_GP:CCP46486.1;Name=CCP46486.1;Note=Rv3663c%2C (MTV025.011c)%2C len: 548 aa. Probable dppD%2Cdipeptide-transport ATP-binding protein ABC-transporter (see citation below)%2C similar to many ATP-binding proteins e.g. AAK65441|SMA1434 probable ABC transporter ATP-binding protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (550 aa)%2C FASTA scores: opt: 1528%2C E(): 1e-78%2C (46.25%25 identity in 545 aa overlap)%3B O50270|MOAD MOAD protein from Agrobacterium radiobacter (588 aa)%2C FASTA scores: opt: 1354%2C E(): 6.7e-69%2C (42.9%25 identity in 541 aa overlap)%3B Q9KM01|VCA0588 putative peptide ABC transporter ATP-binding protein from Vibrio cholerae (530 aa)%2C FASTA scores: opt: 951%2C E(): 3.1e-46%2C (44.0%25 identity in 534 aa overlap)%3B BAB49448|MLR2279 ATP-binding protein of peptide ABC transporter from Rhizobium loti (Mesorhizobium loti) (604 aa)%2C FASTA scores: opt: 949%2C E(): 4.4e-46%2C (41.55%25 identity in 544 aa overlap)%3B etc. Contains 2 PS00211 ABC transporters family signature%2C and 2 PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dppD;inference=protein motif:PROSITE:PS00211;locus_tag=Rv3663c;product=Probable dipeptide-transport ATP-binding protein ABC transporter DppD;protein_id=CCP46486.1;transl_table=11
AL123456.3	EMBL	gene	4103675	4104475	.	-	.	ID=gene-Rv3664c;Name=dppC;gbkey=Gene;gene=dppC;gene_biotype=protein_coding;locus_tag=Rv3664c
AL123456.3	EMBL	CDS	4103675	4104475	.	-	0	ID=cds-CCP46487.1;Parent=gene-Rv3664c;Dbxref=EnsemblGenomes-Gn:Rv3664c,EnsemblGenomes-Tr:CCP46487,GOA:L0TEV4,InterPro:IPR000515,UniProtKB/TrEMBL:L0TEV4,NCBI_GP:CCP46487.1;Name=CCP46487.1;Note=Rv3664c%2C (MTV025.012c)%2C len: 266 aa. Probable dppC%2Cdipeptide-transport integral membrane protein ABC-transporter (see Braibant et al.%2C 2000)%2C similar to many peptide permeases e.g. Q9F351|SC9E12.04 putative peptide transport system integral membrane from Streptomyces coelicolor (305 aa)%2C FASTA scores: opt: 901%2CE(): 1.1e-47%2C (51.15%25 identity in 262 aa overlap)%3B Q9KFX1|APPC|BH0349 oligopeptide ABC transporter (permease) from Bacillus halodurans (305 aa)%2C FASTA scores: opt: 652%2CE(): 1.5e-32%2C (35.55%25 identity in 270 aa overlap)%3B P94312|DPPC_BACFI dipeptide transport system permease protein from Bacillus firmus (304 aa)%2C FASTA scores: opt: 642%2C E(): 5.9e-32%2C (35.75%25 identity in 263 aa overlap)%3B P24139|OPPC_BACSU|SPO0KC oligopeptide transport system permease protein from Bacillus subtilis (305 aa)%2C FASTA scores: opt: 637%2C E(): 1.2e-31%2C (37.4%25 identity in 262 aa overlap)%3B P26904|DPPC_BACSU|DCIAC dipeptide transport system permease protein from Bacillus subtilis (320 aa)%2CFASTA scores: opt: 621%2C E(): 1.2e-30%2C (39.9%25 identity in 263 aa overlap)%3B etc. Has similarity with integral membrane components of other binding-protein-dependent transport systems. Belongs to the OPPBC subfamily.;gbkey=CDS;gene=dppC;locus_tag=Rv3664c;product=Probable dipeptide-transport integral membrane protein ABC transporter DppC;protein_id=CCP46487.1;transl_table=11
AL123456.3	EMBL	gene	4104531	4105457	.	-	.	ID=gene-Rv3665c;Name=dppB;gbkey=Gene;gene=dppB;gene_biotype=protein_coding;locus_tag=Rv3665c
AL123456.3	EMBL	CDS	4104531	4105457	.	-	0	ID=cds-CCP46488.1;Parent=gene-Rv3665c;Dbxref=EnsemblGenomes-Gn:Rv3665c,EnsemblGenomes-Tr:CCP46488,GOA:I6YGV9,InterPro:IPR000515,UniProtKB/TrEMBL:I6YGV9,NCBI_GP:CCP46488.1;Name=CCP46488.1;Note=Rv3665c%2C (MTV025.013c)%2C len: 308 aa. Probable dppB%2Cdipeptide-transport integral membrane protein ABC-transporter (see citation below)%2C similar to many peptide permeases e.g. Q9F352|SC9E12.03 putative peptide transport system integral membrane protein from Streptomyces coelicolor (307 aa)%2C FASTA scores: opt: 1145%2CE(): 1.8e-61%2C (57.65%25 identity in 307 aa overlap)%3B Q53191|Y4TP_RHISN probable peptide ABC transporter permease protein Rhizobium sp. strain NGR234 (313 aa)%2C FASTA scores: opt: 653%2C E(): 5.2e-32%2C (31.2%25 identity in 314 aa overlap)%3B P24138|OPPB_BACSU oligopeptide transport system permease from Bacillus subtilis (311 aa)%2C FASTA scores: opt: 643%2CE(): 2.1e-31%2C (33.45%25 identity in 305 aa overlap)%3B etc. Belongs to the OPPBC subfamily.;gbkey=CDS;gene=dppB;locus_tag=Rv3665c;product=Probable dipeptide-transport integral membrane protein ABC transporter DppB;protein_id=CCP46488.1;transl_table=11
AL123456.3	EMBL	gene	4105459	4107084	.	-	.	ID=gene-Rv3666c;Name=dppA;gbkey=Gene;gene=dppA;gene_biotype=protein_coding;locus_tag=Rv3666c
AL123456.3	EMBL	CDS	4105459	4107084	.	-	0	ID=cds-CCP46489.1;Parent=gene-Rv3666c;Dbxref=EnsemblGenomes-Gn:Rv3666c,EnsemblGenomes-Tr:CCP46489,GOA:I6X811,InterPro:IPR000914,UniProtKB/TrEMBL:I6X811,NCBI_GP:CCP46489.1;Name=CCP46489.1;Note=Rv3666c%2C (MTV025.014c)%2C len: 541 aa. Probable dppA%2Cdipeptide-binding lipoprotein component of dipeptide transport system (see citation below)%2C similar to many substrate-binding proteins e.g. Q9F353|SC9E12.02 putative peptide transport system secreted peptide-binding protein from Streptomyces coelicolor (544 aa)%2C FASTA scores: opt: 1200%2C E(): 9e-67%2C (39.2%25 identity in 538 aa overlap)%3B P24141|OPPA_BACSU oligopeptide-binding protein from Bacillus subtilis (545 aa)%2C FASTA scores: opt: 523%2C E(): 7.9e-25%2C (26.15%25 identity in 516 aa overlap)%3B P23843|OPPA_ECOLI periplasmic oligopeptide-binding protein from Escherichia coli (543 aa)%2C FASTA scores: opt: 452%2CE(): 2e-20%2C (25.9%25 identity in 529 aa overlap)%3B etc. Contains probable N-terminal signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dppA;locus_tag=Rv3666c;product=Probable periplasmic dipeptide-binding lipoprotein DppA;protein_id=CCP46489.1;transl_table=11
AL123456.3	EMBL	gene	4107792	4109747	.	+	.	ID=gene-Rv3667;Name=acs;gbkey=Gene;gene=acs;gene_biotype=protein_coding;locus_tag=Rv3667
AL123456.3	EMBL	CDS	4107792	4109747	.	+	0	ID=cds-CCP46490.1;Parent=gene-Rv3667;Dbxref=EnsemblGenomes-Gn:Rv3667,EnsemblGenomes-Tr:CCP46490,GOA:P9WQD1,InterPro:IPR000873,InterPro:IPR011904,InterPro:IPR020845,InterPro:IPR025110,NCBI_GP:CCP46490.1;Name=CCP46490.1;Note=Rv3667%2C (MTV025.015)%2C len: 651 aa. Probable acs%2Cacetyl-coenzyme-a synthetase%2C similar to many e.g. Q9X928|SCH5.26 from Streptomyces coelicolor (651 aa) FASTA scores: opt: 2850%2C E(): 1.9e-164%2C (66.05%25 identity in 639 aa overlap)%3B Q55404|ACSA_SYNY3|ACS|SLL0542 from Synechocystis sp. strain PCC 6803 (653 aa)%2C FASTA scores: opt: 2342%2C E(): 8.8e-134%2C (55.15%25 identity in 649 aa overlap)%3B P31638|ACSA_ALCEU|ACOE from Alcaligenes eutrophus (Ralstonia eutropha) (660 aa)%2C FASTA scores: opt: 2181%2CE(): 4.6e-124%2C (52.05%25 identity in 665 aa overlap)%3B P27550|ACSA_ECOLI|ACS|B4069 from Escherichia coli strain K12 (652 aa)%2C FASTA scores: opt: 1625%2C E(): 0%2C (48.3%25 identity in 646 aa overlap)%3B etc. Contains PS00455 Putative AMP-binding domain signature. Belongs to the ATP-dependent AMP-binding enzyme family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=acs;inference=protein motif:PROSITE:PS00455;locus_tag=Rv3667;product=Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase);protein_id=CCP46490.1;transl_table=11
AL123456.3	EMBL	gene	4109783	4110481	.	-	.	ID=gene-Rv3668c;Name=Rv3668c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3668c
AL123456.3	EMBL	CDS	4109783	4110481	.	-	0	ID=cds-CCP46491.1;Parent=gene-Rv3668c;Dbxref=EnsemblGenomes-Gn:Rv3668c,EnsemblGenomes-Tr:CCP46491,GOA:I6YGW2,InterPro:IPR009003,UniProtKB/TrEMBL:I6YGW2,NCBI_GP:CCP46491.1;Name=CCP46491.1;Note=Rv3668c%2C (MTV025.016c)%2C len: 232 aa. Possible protease (and more specifically a putative alkaline serine protease%2C equivalent to Q9CB98|ML2295 hypothetical protein from Mycobacterium leprae (234 aa)%2C FASTA scores: opt: 1249%2C E(): 7.4e-66%2C (77.5%25 identity in 231 aa overlap). Also similar at C-terminal end with many proteases e.g. O86984 alkaline serine protease precursor from Thermomonospora fusca (368 aa)%2C FASTA scores: opt: 190%2CE(): 0.00056%2C (28.9%25 identity in 173 aa overlap)%3B Q55353|SAPII alkaline serine protease II from Streptomyces sp (382 aa)%2C FASTA scores: opt: 160%2C E(): 0.032%2C (27.15%25 identity in 199 aa overlap)%3B O54109|SC10A5.18 putative secreted protease from Streptomyces coelicolor (411 aa)%2CFASTA scores: opt: 155%2C E(): 0.066%2C (26.4%25 identity in 163 aa overlap)%3B Q54392|SAL|SCI11.35C serine protease SAL precursor (300 aa)%2C FASTA scores: opt: 153%2C E(): 0.068%2C(28.1%25 identity in 185 aa overlap)%3B P00778|PRLA_LYSEN|alpha-LP alpha-LYTIC protease precursor (397 aa)%2C FASTA scores: opt: 154%2C E(): 0.074%2C (26.75%25 identity in 172 aa overlap)%3B etc. Also similar with Q50618|YI15_MYCTU|Rv1815|MT1863|MTCY1A11.28c hypothetical 22.8 KDA protein from Mycobacterium tuberculosis (221 aa)%2CFASTA scores: opt: 134%2C E(): 0.69%2C (30.95%25 identity in 181 aa overlap). Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3668c;product=Possible protease;protein_id=CCP46491.1;transl_table=11
AL123456.3	EMBL	gene	4110827	4111345	.	+	.	ID=gene-Rv3669;Name=Rv3669;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3669
AL123456.3	EMBL	CDS	4110827	4111345	.	+	0	ID=cds-CCP46492.1;Parent=gene-Rv3669;Dbxref=EnsemblGenomes-Gn:Rv3669,EnsemblGenomes-Tr:CCP46492,GOA:O69637,InterPro:IPR009937,UniProtKB/TrEMBL:O69637,NCBI_GP:CCP46492.1;Name=CCP46492.1;Note=Rv3669%2C (MTV025.017)%2C len: 172 aa. Probable conserved transmembrane protein%2C equivalent to Q9CB97|ML2296 putative membrane protein from Mycobacterium leprae (181 aa)%2C FASTA scores: opt: 863%2C E(): 1.4e-47%2C(77.35%25 identity in 181 aa overlap). Also similar to two putative integral membrane transport proteins from Streptomyces coelicolor%3B Q9X930|SCH5.28 (162 aa) FASTA scores: opt: 265%2C E(): 6.3e-10%2C (37.4%25 identity in 155 aa overlap)%3B and Q9X9W1|SCI7.29c (165 aa)%2C FASTA scores: opt: 194%2C E(): 1.9e-05%2C (30.6%25 identity in 134 aa overlap). Contains two hydrophobic stretches in centre.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3669;product=Probable conserved transmembrane protein;protein_id=CCP46492.1;transl_table=11
AL123456.3	EMBL	gene	4111346	4112329	.	+	.	ID=gene-Rv3670;Name=ephE;gbkey=Gene;gene=ephE;gene_biotype=protein_coding;locus_tag=Rv3670
AL123456.3	EMBL	CDS	4111346	4112329	.	+	0	ID=cds-CCP46493.1;Parent=gene-Rv3670;Dbxref=EnsemblGenomes-Gn:Rv3670,EnsemblGenomes-Tr:CCP46493,GOA:I6YCQ4,InterPro:IPR000639,InterPro:IPR029058,UniProtKB/TrEMBL:I6YCQ4,NCBI_GP:CCP46493.1;Name=CCP46493.1;Note=Rv3670%2C (MTV025.018)%2C len: 327 aa. Possible ephE%2Cepoxide hydrolase (see citation below)%2C equivalent to Q9CB96|ML2297 putative hydrolase from Mycobacterium leprae (324 aa)%2C FASTA scores: opt: 1799%2C E(): 7.2e-105%2C (80.55%25 identity in 324 aa overlap). Also similar to many hydrolases (epoxide hydrolases) and hypothetical proteins e.g. Q9X931|SCH5.29 putative hydrolase from Streptomyces coelicolor (324 aa)%2C FASTA scores: opt: 687%2C E(): 1.4e-35%2C(40.65%25 identity in 327 aa overlap)%3B Q9RRE3|DR2549 epoxide hydrolase-related protein from Deinococcus radiodurans (278 aa)%2C FASTA scores: opt: 321%2C E(): 8.2e-13%2C (32.15%25 identity in 311 aa overlap)%3B Q9K3Q1|2SCG4.13 putative hydrolase from Streptomyces coelicolor (292 aa)%2C FASTA scores: opt: 295%2CE(): 3.5e-11%2C (30.18%25 identity in 275 aa overlap)%3B Q9S7P1 epoxide hydrolase from Oryza sativa (Rice) (322 aa)%2C FASTA scores: opt: 289%2C E(): 9.1e-11%2C (28.7%25 identity in 338 aa overlap)%3B O23227|C7A10.830|AT4G36530 epoxide hydrolase from Arabidopsis thaliana (Mouse-ear cress) (378 aa) FASTA scores: opt: 287%2C E(): 1.4e-10%2C (26.1%25 identity in 272 aa overlap)%3B Q21147|K02F3.6 epoxide hydrolase from Caenorhabditis elegans (386 aa)%2C FASTA scores: opt: 283%2CE(): 2.5e-10%2C (33.35%25 identity in 156 aa overlap)%3B etc. Also similar to P95276|EPHB|Rv1938|MTCY09F9.26c from Mycobacterium tuberculosis (356 aa)%2C FASTA scores: opt: 296%2C E(): 3.6e-11%2C (29.7%25 identity in 340 aa overlap). Contains PS00213 Lipocalin signature. Similar to alpha/beta hydrolase fold.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ephE;inference=protein motif:PROSITE:PS00213;locus_tag=Rv3670;product=Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase);protein_id=CCP46493.1;transl_table=11
AL123456.3	EMBL	gene	4112322	4113515	.	-	.	ID=gene-Rv3671c;Name=Rv3671c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3671c
AL123456.3	EMBL	CDS	4112322	4113515	.	-	0	ID=cds-CCP46494.1;Parent=gene-Rv3671c;Dbxref=EnsemblGenomes-Gn:Rv3671c,EnsemblGenomes-Tr:CCP46494,GOA:P9WHR9,InterPro:IPR001254,InterPro:IPR001940,InterPro:IPR003825,InterPro:IPR009003,InterPro:IPR015724,InterPro:IPR018114,PDB:3K6Y,PDB:3K6Z,PDB:3LT3,NCBI_GP:CCP46494.1;Name=CCP46494.1;Note=Rv3671c%2C (MTV025.019c)%2C len: 397 aa. Serine protease membrane protein%2C equivalent to Q9CB95|ML2298 putative membrane-associated serine protease from Mycobacterium leprae (401 aa)%2C FASTA scores: opt: 2061%2C E(): 2.3e-108%2C(80.9%25 identity in 398 aa overlap). Also similar to many serine proteases%2C but generally with extended N-terminus%2Ce.g. Q9X932|SCH5.30c putative serine protease (fragment) from Streptomyces coelicolor (385 aa)%2C FASTA scores: opt: 835%2C E(): 1.2e-39%2C (39.9%25 identity in 386 aa overlap)%3B Q9Z6T0|DEGP_CHLPN|HTRA|CPN0979|CP0877 probable serine protease do-like precursor from Chlamydia pneumoniae (Chlamydophila pneumoniae) (488 aa)%2C FASTA scores: opt: 285%2C E(): 1e-08%2C (29.05%25 identity in 296 aa overlap)%3B P73354|HTRA|SLR1204 serine protease from Synechocystis sp. strain PCC 6803 (452 aa)%2C FASTA scores: opt: 284%2C E(): 1.1e-08%2C (29.55%25 identity in 308 aa overlap)%3B Q9RWC4|DR0745 periplasmic serine protease%2C HTRA/DEGQ/DEGS family from Deinococcus radiodurans (366 aa)%2C FASTA scores: opt: 271%2CE(): 4.9e-08%2C (35.45%25 identity in 206 aa overlap)%3B etc. Also similar%2C but longer 114 aa at the N-terminus%2C to Q9S2P8|SC5F7.13 putative peptidase from Streptomyces coelicolor (282 aa)%2C FASTA scores: opt: 594%2C E(): 3.1e-26%2C(38.95%25 identity in 285 aa overlap). And similar%2C but longer 146 aa at the N-terminus%2C to O07175|PEPA|Rv0125|MTCI418B.07 from Mycobacterium tuberculosis (355 aa)%2C FASTA scores: opt: 295%2C E(): 2.2e-09%2C (29.55%25 identity in 254 aa overlap)%3B and Q9CCY9|ML2659 probable secreted serine protease from Mycobacterium leprae FASTA scores: opt: 286%2C E(): 6.9e-09%2C(30.6%25 identity in 255 aa overlap). Contains PS00135 Serine proteases%2C trypsin family%2C serine active site. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00135;locus_tag=Rv3671c;product=Membrane-associated serine protease;protein_id=CCP46494.1;transl_table=11
AL123456.3	EMBL	gene	4113521	4114342	.	-	.	ID=gene-Rv3672c;Name=Rv3672c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3672c
AL123456.3	EMBL	CDS	4113521	4114342	.	-	0	ID=cds-CCP46495.1;Parent=gene-Rv3672c;Dbxref=EnsemblGenomes-Gn:Rv3672c,EnsemblGenomes-Tr:CCP46495,GOA:I6XHX8,InterPro:IPR000059,InterPro:IPR000086,InterPro:IPR015797,UniProtKB/TrEMBL:I6XHX8,NCBI_GP:CCP46495.1;Name=CCP46495.1;Note=Rv3672c%2C (MTV025.020c)%2C len: 273 aa. Conserved hypothetical protein%2C equivalent to Q9CB94|ML2299 hypothetical protein from Mycobacterium leprae (266 aa) FASTA scores: opt: 1358%2C E(): 5.2e-75%2C (76.4%25 identity in 267 aa overlap). Also similar to others (generally in C-terminal end) e.g. Q9XA45|SCH17.02c hypothetical 26.5 KDA protein from Streptomyces coelicolor (247 aa) FASTA scores: opt: 524%2C E(): 1.3e-24%2C (42.65%25 identity in 251 aa overlap)%3B Q9AB27|CC0407 mutt/NUDIX family protein from Caulobacter crescentus (216 aa)%2C FASTA scores: opt: 285%2CE(): 3.2e-10%2C (36.2%25 identity in 174 aa overlap)%3B BAB49788|MLL2727|Q98HS8 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (204 aa)%2C FASTA scores: opt: 278%2CE(): 8.1e-10%2C (31.45%25 identity in 151 aa overlap)%3B P43337|YEAB_ECOLI|B1813 hypothetical 21.4 KDA protein from Escherichia coli strain K12 (192 aa) FASTA scores: opt: 252%2C E(): 2.9e-08%2C (35.9%25 identity in 170 aa overlap)%3B etc. Contains PS01293 Uncharacterized protein family UPF0036 signature%2C LLT.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01293;locus_tag=Rv3672c;product=Conserved hypothetical protein;protein_id=CCP46495.1;transl_table=11
AL123456.3	EMBL	gene	4114474	4115157	.	-	.	ID=gene-Rv3673c;Name=Rv3673c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3673c
AL123456.3	EMBL	CDS	4114474	4115157	.	-	0	ID=cds-CCP46496.1;Parent=gene-Rv3673c;Dbxref=EnsemblGenomes-Gn:Rv3673c,EnsemblGenomes-Tr:CCP46496,GOA:I6YGW6,InterPro:IPR005746,InterPro:IPR012336,InterPro:IPR013740,InterPro:IPR017937,UniProtKB/TrEMBL:I6YGW6,NCBI_GP:CCP46496.1;Name=CCP46496.1;Note=Rv3673c%2C (MTV025.021c)%2C len: 227 aa. Possible membrane protein%2C thioredoxin-like protein (thiol-disulfide interchange protein)%2C equivalent to Q9CB93|ML2300 putative membrane protein from Mycobacterium leprae (215 aa)%2C FASTA scores: opt: 978%2C E(): 2.5e-52%2C (71.15%25 identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA protein from Bacillus subtilis (181 aa)%2C FASTA scores: opt: 212%2C E(): 5.7e-06%2C (30.55%25 identity in 108 aa overlap)%3B Q9RXW6|DR0189 thiol:disulfide interchange protein from Deinococcus radiodurans (185 aa) FASTA scores: opt: 206%2C E(): 1.3e-05%2C (33.8%25 identity in 139 aa overlap)%3B Q9I505|PA0953 probable thioredoxin from Pseudomonas aeruginosa (154 aa)%2C FASTA scores: opt: 180%2CE(): 0.00044%2C (34.85%25 identity in 109 aa overlap)%3B Q9KCP7|BH1522 thioredoxin (thiol:disulfide interchange protein) from Bacillus halodurans (177 aa)%2C FASTA scores: opt: 178%2C E(): 0.00064%2C (31.75%25 identity in 107 aa overlap)%3B P43221|TLPA_BRAJA thiol:disulfide interchange protein (cytochrome C biogenesis protein) from Bradyrhizobium japonicum (221 aa)%2C FASTA scores: opt: 189%2CE(): 0.00017%2C (26.85%25 identity in 227 aa overlap)%3B etc. Also similar to O06392|Rv0526|MTCY25D10.05 hypothetical 23.2 KDA protein from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 160%2C E(): 0.0093%2C (27.45%25 identity in 142 aa overlap). Contains PS00194 Thioredoxin family active site. Possibly belongs to the thioredoxin family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00194;locus_tag=Rv3673c;product=Possible membrane-anchored thioredoxin-like protein (thiol-disulfide interchange related protein);protein_id=CCP46496.1;transl_table=11
AL123456.3	EMBL	gene	4115157	4115894	.	-	.	ID=gene-Rv3674c;Name=nth;gbkey=Gene;gene=nth;gene_biotype=protein_coding;locus_tag=Rv3674c
AL123456.3	EMBL	CDS	4115157	4115894	.	-	0	ID=cds-CCP46497.1;Parent=gene-Rv3674c;Dbxref=EnsemblGenomes-Gn:Rv3674c,EnsemblGenomes-Tr:CCP46497,GOA:P9WQ11,InterPro:IPR000445,InterPro:IPR003265,InterPro:IPR003583,InterPro:IPR003651,InterPro:IPR004035,InterPro:IPR004036,InterPro:IPR005759,InterPro:IPR011257,InterPro:IPR023170,NCBI_GP:CCP46497.1;Name=CCP46497.1;Note=Rv3674c%2C (MT3775%2C MTV025.022c)%2C len: 245 aa. Probable nth%2C endonuclease III (see citation below)%2Cequivalent to Q9CB92|nth|ML2301 putative endonuclease III from Mycobacterium leprae (272 aa)%2C FASTA scores: opt: 1363%2C E(): 3.6e-81%2C (89.4%25 identity in 226 aa overlap). Also similar to many e.g. Q9XA44|SCH17.03c from Streptomyces coelicolor (250 aa)%2C FASTA scores: opt: 937%2CE(): 2.2e-55%2C (61.65%25 identity in 219 aa overlap)%3B P46303|UVEN_MICLU from Micrococcus luteus (Micrococcus lysodeikticus) (279 aa)%2C FASTA scores: opt: 899%2C E(): 8.1e-53%2C (58.45%25 identity in 248 aa overlap)%3B P73715|END3_SYNY3|nth|SLR1822 from Synechocystis sp. strain PCC 6803 (219 aa)%2C FASTA scores: opt: 684%2C E(): 1.7e-38%2C(52.2%25 identity in 203 aa overlap)%3B P39788|END3_BACSU|nth|JOOB from Bacillus subtilis (219 aa)%2CFASTA scores: opt: 552%2C E(): 1.2e-29%2C (43.3%25 identity in 194 aa overlap)%3B etc. Equivalent to AAK48142 from Mycobacterium tuberculosis strain CDC1551 (262 aa) but shorter 17 aa. Contains PS00764 Endonuclease III iron-sulfur binding region signature%2C and PS01155 Endonuclease III family signature. Belongs to the nth/MUTY family. Cofactor: binds a 4FE-4S cluster which is not important for the catalytic activity%2C but which is probably involved in the proper positioning of the enzyme along the DNA strand (by similarity). N-terminus extended since first submission (previously 226 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=nth;inference=protein motif:PROSITE:PS01155;locus_tag=Rv3674c;product=Probable endonuclease III Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic));protein_id=CCP46497.1;transl_table=11
AL123456.3	EMBL	gene	4116002	4116379	.	+	.	ID=gene-Rv3675;Name=Rv3675;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3675
AL123456.3	EMBL	CDS	4116002	4116379	.	+	0	ID=cds-CCP46498.1;Parent=gene-Rv3675;Dbxref=EnsemblGenomes-Gn:Rv3675,EnsemblGenomes-Tr:CCP46498,UniProtKB/TrEMBL:I6YCQ7,NCBI_GP:CCP46498.1;Name=CCP46498.1;Note=Rv3675%2C (MTV025.023)%2C len: 125 aa. Possible membrane protein%2C with some similarity to Q9YCZ2|APE1120 hypothetical 11.7 KDA protein from Aeropyrum pernix (103 aa)%2C FASTA scores: opt: 100%2C E(): 9%2C (40.0%25 identity in 55 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3675;product=Possible membrane protein;protein_id=CCP46498.1;transl_table=11
AL123456.3	EMBL	gene	4116478	4117152	.	+	.	ID=gene-Rv3676;Name=crp;gbkey=Gene;gene=crp;gene_biotype=protein_coding;locus_tag=Rv3676
AL123456.3	EMBL	CDS	4116478	4117152	.	+	0	ID=cds-CCP46499.1;Parent=gene-Rv3676;Dbxref=EnsemblGenomes-Gn:Rv3676,EnsemblGenomes-Tr:CCP46499,GOA:P9WMH3,InterPro:IPR000595,InterPro:IPR001808,InterPro:IPR011991,InterPro:IPR012318,InterPro:IPR014710,InterPro:IPR018490,PDB:3D0S,PDB:3H3U,PDB:3I54,PDB:3I59,PDB:3MZH,NCBI_GP:CCP46499.1;Name=CCP46499.1;Note=Rv3676%2C (MTV025.024)%2C len: 224 aa. Crp%2Ctranscriptional regulator belonging to crp/fnr family%2Cidentical to Q9CB91|ML2302 putative Crp/Fnr-family transcriptional regulator from Mycobacterium leprae (224 aa)%2C FASTA scores: opt: 1408%2C E(): 8.8e-81%2C (95.95%25 identity in 224 aa overlap). Also highly similar to transcriptional regulators AAK58838 from Corynebacterium glutamicum (Brevibacterium flavum) (227 aa)%2C FASTA scores: opt: 1178%2C E(): 1.9e-66%2C (79.9%25 identity in 224 aa overlap)%3B and Q9XA42|SCH17.05 from Streptomyces coelicolor (224 aa)%2C FASTA scores: opt: 869%2C E(): 3.4e-47%2C (54.45%25 identity in 224 aa overlap)%3B and similar to others e.g. Q9RRX0|DR2362 from Deinococcus radiodurans (231 aa) FASTA scores: opt: 344%2C E(): 1.8e-14%2C (30.8%25 identity in 211 aa overlap)%3B P29281|CRP_HAEIN from Haemophilus influenzae (224 aa)%2C FASTA scores: opt: 330%2C E(): 1.3e-13%2C (32.25%25 identity in 189 aa overlap)%3B P03020|CRP_ECOLI|cap|CSM|B3357 from Escherichia coli strain K12 and Shigella flexneri (210 aa)%2CFASTA scores: opt: 323%2C E(): 3.5e-13%2C (32.25%25 identity in 189 aa overlap)%3B etc. Contains helix-turn-helix motif at aa 175-196 (Score 1990%2C +5.96 SD). Belongs to the Crp/Fnr family of transcriptional regulators. Binds cAMP.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=crp;locus_tag=Rv3676;product=Transcriptional regulatory protein Crp (Crp/Fnr-family);protein_id=CCP46499.1;transl_table=11
AL123456.3	EMBL	gene	4117258	4118052	.	-	.	ID=gene-Rv3677c;Name=Rv3677c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3677c
AL123456.3	EMBL	CDS	4117258	4118052	.	-	0	ID=cds-CCP46500.1;Parent=gene-Rv3677c;Dbxref=EnsemblGenomes-Gn:Rv3677c,EnsemblGenomes-Tr:CCP46500,GOA:I6XHY3,InterPro:IPR001279,UniProtKB/TrEMBL:I6XHY3,NCBI_GP:CCP46500.1;Name=CCP46500.1;Note=Rv3677c%2C (MTV025.025c)%2C len: 264 aa. Possible hydrolase%2C equivalent to Q9CB90|ML2303 putative hydrolase from Mycobacterium leprae (262 aa) FASTA scores: opt: 1400%2CE(): 8.5e-81%2C (82.05%25 identity in 262 aa overlap). Also similar to other hydrolases and hypothetical proteins e.g. Q9XA41|SCH17.06c putative hydrolase from Streptomyces coelicolor (256 aa) FASTA scores: opt: 609%2C E(): 3.9e-31%2C(54.65%25 identity in 247 aa overlap)%3B Q9A9Q1|CC0923 metallo-beta-lactamase family protein from Caulobacter crescentus (297 aa)%2C FASTA scores: opt: 306%2C E(): 4.7e-12%2C(35.45%25 identity in 268 aa overlap)%3B Q9Y392 CGI-83 protein from Homo sapiens (Human) (288 aa)%2C FASTA scores: opt: 281%2CE(): 1.7e-10%2C (33.2%25 identity in 259 aa overlap)%3B Q9F7R6 predicted metallobeta lactamase fold protein from uncultured proteobacterium EBAC31A08 (265 aa)%2C FASTA scores: opt: 257%2C E(): 5.1e-09%2C (32.55%25 identity in 252 aa overlap)%3B Q9PBI4|XF2160 hydroxyacylglutathione hydrolase from Xylella fastidiosa (258 aa)%2C FASTA scores: opt: 232%2CE(): 1.9e-07%2C (30.3%25 identity in 165 aa overlap)%3B etc. Recombinant protein has beta lactamase activity (See Nampoothiri et al.%2C 2008).;gbkey=CDS;locus_tag=Rv3677c;product=Possible hydrolase;protein_id=CCP46500.1;transl_table=11
AL123456.3	EMBL	gene	4118059	4118514	.	-	.	ID=gene-Rv3678c;Name=Rv3678c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3678c
AL123456.3	EMBL	CDS	4118059	4118514	.	-	0	ID=cds-CCP46501.1;Parent=gene-Rv3678c;Dbxref=EnsemblGenomes-Gn:Rv3678c,EnsemblGenomes-Tr:CCP46501,InterPro:IPR006175,InterPro:IPR013813,UniProtKB/TrEMBL:I6YGW9,NCBI_GP:CCP46501.1;Name=CCP46501.1;Note=Rv3678c%2C (MTV025.026c)%2C len: 151 aa. Conserved protein%2C equivalent%2C but shorter 23 aa%2C to Q9CB89|ML2304 hypothetical protein from Mycobacterium leprae (174 aa)%2CFASTA scores: opt: 746%2C E(): 2.1e-40%2C (78.15%25 identity in 151 aa overlap). Also highly similar to many hypothetical proteins or transcription regulators e.g. Q9XA38|SCH17.09c from Streptomyces coelicolor (155 aa)%2C FASTA scores: opt: 637%2C E(): 1.5e-33%2C (69.1%25 identity in 152 aa overlap)%3B BAB48205|MLR0658 from Rhizobium loti (Mesorhizobium loti) (154 aa)%2C FASTA scores: opt: 500%2C E(): 6.8e-25%2C (55.35%25 identity in 150 aa overlap)%3B BAB50615|MLR3802 transcription regulator from Rhizobium loti (Mesorhizobium loti) (153 aa)%2C FASTA scores: opt: 425%2CE(): 3.8e-20%2C (44.35%25 identity in 151 aa overlap)%3B Q9U0W7|L7276.02 from Leishmania major (163 aa) FASTA scores: opt: 404%2C E(): 8.5e-19%2C (47.7%25 identity in 151 aa overlap)%3B Q9UZA3|PAB0825 putative translation initiation inhibitor from Pyrococcus abyssi (127 aa)%2C FASTA scores: opt: 108%2C E(): 3.7%2C (30.75%25 identity in 130 aa overlap)%3B etc. Contains PS00044 Bacterial regulatory proteins%2C lysR family signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00044;locus_tag=Rv3678c;product=Conserved protein;protein_id=CCP46501.1;transl_table=11
AL123456.3	EMBL	gene	4118530	4118691	.	-	.	ID=gene-Rv3678A;Name=Rv3678A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3678A
AL123456.3	EMBL	CDS	4118530	4118691	.	-	0	ID=cds-CCP46502.1;Parent=gene-Rv3678A;Dbxref=EnsemblGenomes-Gn:Rv3678A,EnsemblGenomes-Tr:CCP46502,InterPro:IPR025234,UniProtKB/TrEMBL:I6X824,NCBI_GP:CCP46502.1;Name=CCP46502.1;Note=Rv3678A%2C len: 53 aa. Conserved hypothetical protein%2Csimilar to SCH17.10|AL079353_10 conserved hypothetical protein from Streptomyces coelicolor (53 aa)%2C FASTA scores: opt: 259%2C E(): 1.5e-13%2C (78.0%25 identity in 50 aa overlap).;gbkey=CDS;locus_tag=Rv3678A;product=Conserved hypothetical protein;protein_id=CCP46502.1;transl_table=11
AL123456.3	EMBL	gene	4118776	4119798	.	+	.	ID=gene-Rv3679;Name=Rv3679;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3679
AL123456.3	EMBL	CDS	4118776	4119798	.	+	0	ID=cds-CCP46503.1;Parent=gene-Rv3679;Dbxref=EnsemblGenomes-Gn:Rv3679,EnsemblGenomes-Tr:CCP46503,GOA:P9WKX5,InterPro:IPR016300,InterPro:IPR025723,InterPro:IPR027417,NCBI_GP:CCP46503.1;Name=CCP46503.1;Note=Rv3679%2C (MTV025.027)%2C len: 340 aa. Probable anion transporting ATPase%2C equivalent to Q9CB88|ML2305 probable anion transporter protein from Mycobacterium leprae (341 aa)%2C FASTA scores: opt: 1810%2C E(): 2.1e-98%2C (84.15%25 identity in 341 aa overlap). Also highly similar to Q9XA36|SCH17.11 putative ion-transporting ATPase from Streptomyces coelicolor (325 aa)%2C FASTA scores: opt: 989%2CE(): 1.4e-50%2C (52.15%25 identity in 328 aa overlap)%3B and similar to many anion transporting ATPases (principally arsenite transporters) e.g. O50593|ARSA_ACIMU arsenical pump-driving ATPase (arsenite-translocating ATPase) from Acidiphilium multivorum (583 aa)%2C FASTA scores: opt: 225%2CE(): 8.1e-06%2C (25.1%25 identity in 319 aa overlap)%3B AAG43231|ARSA arsenite activated ATPase from Salmonella typhimurium plasmid R46 FASTA scores: opt: 211%2C E(): 5.3e-05%2C (26.95%25 identity in 267 aa overlap)%3B P52145|ARA2_ECOLI|ARSA arsenical pump-driving ATPase from Escherichia coli plasmid IncN R46 (583 aa)%2C FASTA scores: opt: 211%2C E(): 5.3e-05%2C (26.95%25 identity in 267 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Some similarity to the ARSA ATPase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3679;product=Probable anion transporter ATPase;protein_id=CCP46503.1;transl_table=11
AL123456.3	EMBL	gene	4119795	4120955	.	+	.	ID=gene-Rv3680;Name=Rv3680;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3680
AL123456.3	EMBL	CDS	4119795	4120955	.	+	0	ID=cds-CCP46504.1;Parent=gene-Rv3680;Dbxref=EnsemblGenomes-Gn:Rv3680,EnsemblGenomes-Tr:CCP46504,GOA:I6Y498,InterPro:IPR016300,InterPro:IPR025723,InterPro:IPR027417,UniProtKB/TrEMBL:I6Y498,NCBI_GP:CCP46504.1;Name=CCP46504.1;Note=Rv3680%2C (MTV025.028)%2C len: 386 aa. Probable anion transporting ATPase%2C equivalent to Q9CB87|ML2306 probable anion transporter protein from Mycobacterium leprae (381 aa)%2C FASTA scores: opt: 2131%2C E(): 6.5e-120%2C (88.1%25 identity in 370 aa overlap). Also highly similar%2C but shorter 29 aa%2C to Q9XA35|SCH17.12 putative ion-transporting ATPase from Streptomyces coelicolor (481 aa)%2C FASTA scores: opt: 1190%2C E(): 1.1e-63%2C (51.25%25 identity in 441 aa overlap)%3B and similar to many anion transporting ATPases e.g. Q9UZA6|PAB1555 anion transporting ATPase from Pyrococcus abyssi (330 aa) FASTA scores: opt: 242%2C E(): 3e-07%2C (24.6%25 identity in 297 aa overlap)%3B Q9P7F8|SPAC1142.06 putative arsenite-translocating from Schizosaccharomyces pombe (Fission yeast) (329 aa)%2C FASTA scores: opt: 239%2C E(): 4.5e-07%2C (27.9%25 identity in 197 aa overlap)%3B Q9HS79|ARSA1|VNG0365G arsenical pump-driving ATPase from Halobacterium sp. strain NRC-1 (347 aa)%2C FASTA scores: opt: 238%2C E(): 5.4e-07%2C (29.35%25 identity in 358 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3680;product=Probable anion transporter ATPase;protein_id=CCP46504.1;transl_table=11
AL123456.3	EMBL	gene	4121198	4121554	.	-	.	ID=gene-Rv3681c;Name=whiB4;gbkey=Gene;gene=whiB4;gene_biotype=protein_coding;gene_synonym=whmA;locus_tag=Rv3681c
AL123456.3	EMBL	CDS	4121198	4121554	.	-	0	ID=cds-CCP46505.1;Parent=gene-Rv3681c;Dbxref=EnsemblGenomes-Gn:Rv3681c,EnsemblGenomes-Tr:CCP46505,GOA:P9WF39,InterPro:IPR003482,NCBI_GP:CCP46505.1;Name=CCP46505.1;Note=Rv3681c%2C (MTV025.029c)%2C len: 118 aa. Probable whiB4 (alternate gene name: whmA)%2C WhiB-like regulatory protein (see Hutter %26 Dick 1999)%2C similar to WhiB paralogue of Streptomyces coelicolor%2C wblE gene product (85 aa). Equivalent to ML2307 hypothetical protein from Mycobacterium leprae (116 aa). Also highly similar to Q9S2B9|SCH17.13c putative regulatory protein from Streptomyces coelicolor (112 aa)%2C FASTA scores: opt: 392%2CE(): 1e-20%2C (67.95%25 identity in 78 aa overlap)%3B Q9X951|WBLA hypothetical 14.3 KDA protein from Streptomyces coelicolor (129 aa)%2C FASTA scores: opt: 392%2C E(): 1.1e-20%2C (67.95%25 identity in 78 aa overlap)%3B Q9ACZ0|SCP1.161c putative regulatory protein from Streptomyces coelicolor (268 aa)%2CFASTA scores: opt: 273%2C E(): 4.4e-12%2C (50.0%25 identity in 78 aa overlap)%3B Q06387|WHIB-STV from Streptomyces griseocarneus (87 aa) FASTA scores: opt: 231%2C E(): 1.5e-09%2C(43.85%25 identity in 73 aa overlap)%3B etc. Also similar to several putative regulator proteins from Mycobacterium tuberculosis e.g. MTCY7D11_7%3B MTCY78_13%3B MTCY10H4_23%3B MTCY1A6_6%3B and U00016_29 from Mycobacterium leprae. N-terminus shortened since first submission.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=whiB4;locus_tag=Rv3681c;product=Probable transcriptional regulatory protein WhiB-like WhiB4;protein_id=CCP46505.1;transl_table=11
AL123456.3	EMBL	gene	4121916	4124348	.	+	.	ID=gene-Rv3682;Name=ponA2;gbkey=Gene;gene=ponA2;gene_biotype=protein_coding;locus_tag=Rv3682
AL123456.3	EMBL	CDS	4121916	4124348	.	+	0	ID=cds-CCP46506.1;Parent=gene-Rv3682;Dbxref=EnsemblGenomes-Gn:Rv3682,EnsemblGenomes-Tr:CCP46506,GOA:I6YGX2,InterPro:IPR001264,InterPro:IPR001460,InterPro:IPR005543,InterPro:IPR012338,InterPro:IPR023346,PDB:2MGV,UniProtKB/TrEMBL:I6YGX2,NCBI_GP:CCP46506.1;Name=CCP46506.1;Note=Rv3682%2C (MTV025.030)%2C len: 810 aa. Probable ponA2%2Cpenicillin-binding protein (class A)%2C bienzymatic membrane-associated protein with transglycosylase and transpeptidase activities. Almost identical to Q9CB85|PON1|ML2308 penicillin binding protein (class A) from Mycobacterium leprae (803 aa) FASTA scores: opt: 4743%2CE(): 3.3e-217%2C (87.7%25 identity in 806 aa overlap)%3B or P72351|PON1|PBP1 high-molecular-mass class a penicillin binding protein from Mycobacterium leprae Cosmid B577 (821 aa)%2C FASTA scores: opt: 4547%2C E(): 6.3e-208%2C (88.05%25 identity in 769 aa overlap) (see Basu et al.%2C 1996). Also equivalent to a predicted homologous protein from Mycobacterium smegmatis. Also similar to others e.g. Q9XA34|SCH17.14 from Streptomyces coelicolor (428 aa%3B fragment)%2C FASTA scores: opt: 727%2C E(): 2.3e-27%2C (36.55%25 identity in 413 aa overlap)%3B Q9F9V7|PONA from Mycobacterium smegmatis (715 aa)%2C FASTA scores: opt: 446%2C E(): 6.6e-14%2C(27.65%25 identity in 771 aa overlap) (see Billman-Jacobe et al.%2C 1999)%3B Q9CCY4|PONA|ML2688 from Mycobacterium leprae (708 aa)%2C FASTA scores: opt: 413%2C E(): 2.4e-12%2C (26.8%25 identity in 660 aa overlap)%3B Q9X6W0|PONB|MRCB|PA4700 from Pseudomonas aeruginosa (774 aa)%2C FASTA scores: opt: 398%2CE(): 1.3e-11%2C (27.2%25 identity in 666 aa overlap)%3B P45345|PBPB_HAEIN|MRCB|PONB|HI1725 (781 aa)%2C FASTA scores: opt: 380%2C E(): 9.4e-11%2C (28.6%25 identity in 601 aa overlap)%3B etc. Also similar to P71707|PONA1|Rv0050|MTCY21.13 probable bifunctional penicillin-binding protein 1A/1B (PBP1) from Mycobacterium tuberculosis (678 aa) FASTA scores: opt: 372%2CE(): 2e-10%2C (28.35%25 identity in 769 aa overlap). Seems to belong to the transglycosylase family in the N-terminal section%2C and to the transpeptidase family in the C-terminal section.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ponA2;locus_tag=Rv3682;product=Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)];protein_id=CCP46506.1;transl_table=11
AL123456.3	EMBL	gene	4124417	4125376	.	+	.	ID=gene-Rv3683;Name=Rv3683;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3683
AL123456.3	EMBL	CDS	4124417	4125376	.	+	0	ID=cds-CCP46507.1;Parent=gene-Rv3683;Dbxref=EnsemblGenomes-Gn:Rv3683,EnsemblGenomes-Tr:CCP46507,GOA:I6X827,InterPro:IPR004843,InterPro:IPR029052,UniProtKB/TrEMBL:I6X827,NCBI_GP:CCP46507.1;Name=CCP46507.1;Note=Rv3683%2C (MTV025.031)%2C len: 319 aa. Conserved protein%2C equivalent to Q9CB84|ML2309 hypothetical protein from Mycobacterium leprae (330 aa) FASTA scores: opt: 1791%2CE(): 9e-107%2C (85.45%25 identity in 296 aa overlap). Also similar to Q9X935|SCH66.03 conserved hypothetical protein from Streptomyces coelicolor (309 aa) FASTA scores: opt: 610%2C E(): 1.4e-31%2C (51.45%25 identity in 307 aa overlap)%3B and Q9RRY7|YN45_DEIRA|DR2345 hypothetical protein from Deinococcus radiodurans (305 aa) FASTA scores: opt: 243%2CE(): 3.2e-08%2C (31.1%25 identity in 315 aa overlap) and some similarity to other hypothetical bacterial proteins e.g. Q9CF81|YQED from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (278 aa) FASTA scores: opt: 200%2CE(): 1.6e-05%2C (26.85%25 identity in 287 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3683;product=Conserved protein;protein_id=CCP46507.1;transl_table=11
AL123456.3	EMBL	gene	4125439	4126479	.	+	.	ID=gene-Rv3684;Name=Rv3684;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3684
AL123456.3	EMBL	CDS	4125439	4126479	.	+	0	ID=cds-CCP46508.1;Parent=gene-Rv3684;Dbxref=EnsemblGenomes-Gn:Rv3684,EnsemblGenomes-Tr:CCP46508,GOA:O69652,InterPro:IPR001926,UniProtKB/TrEMBL:O69652,NCBI_GP:CCP46508.1;Name=CCP46508.1;Note=Rv3684%2C (MTV025.032)%2C len: 346 aa. Probable lyase %2Cand more specifically a cysteine synthase%2C highly similar to many lyases e.g. Q9K3N2|SCG20A.08c putative lyase from Streptomyces coelicolor (374 aa)%2C FASTA scores: opt: 1469%2CE(): 3.7e-85%2C (63.35%25 identity in 341 aa overlap) (shorter 31 aa at N-terminus)%3B Q9KT44|VC1061 cysteine synthase/ cystathionine beta-synthase family protein from Vibrio cholerae (355 aa)%2C FASTA scores: opt: 1366%2C E(): 1.1e-78%2C(63.25%25 identity in 321 aa overlap)%3B Q9I4R3|PA1061 hypothetical protein from Pseudomonas aeruginosa (365 aa)%2CFASTA scores: opt: 1311%2C E(): 3.2e-75%2C (59.8%25 identity in 341 aa overlap)%3B Q9PH18|XF0128 cysteine synthase from Xylella fastidiosa (390 aa)%2C FASTA scores: opt: 1288%2C E(): 9.5e-74%2C (58.55%25 identity in 333 aa overlap) (shorter 34 aa at N-terminus)%3B P55708|Y4XP_RHISN putative cysteine synthase from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (336 aa)%2C FASTA scores: opt: 376%2C E(): 2.1e-16%2C(29.2%25 identity in 315 aa overlap)%3B etc. Equivalent to AAK48153 from Mycobacterium tuberculosis strain CDC1551 (368 aa) but shorter 22 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3684;product=Probable lyase;protein_id=CCP46508.1;transl_table=11
AL123456.3	EMBL	gene	4126541	4126614	.	+	.	ID=gene-proY;Name=proY;gbkey=Gene;gene=proY;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	4126541	4126614	.	+	.	ID=rna-proY;Parent=gene-proY;Note=codon recognized: CCG%3B proY%2C tRNA-Pro%2C anticodon cgg%2C length %3D 74;anticodon=(pos:4126575..4126577);gbkey=tRNA;gene=proY;product=tRNA-Pro
AL123456.3	EMBL	exon	4126541	4126614	.	+	.	ID=exon-proY-1;Parent=rna-proY;Note=codon recognized: CCG%3B proY%2C tRNA-Pro%2C anticodon cgg%2C length %3D 74;anticodon=(pos:4126575..4126577);gbkey=tRNA;gene=proY;product=tRNA-Pro
AL123456.3	EMBL	gene	4127295	4128725	.	-	.	ID=gene-Rv3685c;Name=cyp137;gbkey=Gene;gene=cyp137;gene_biotype=protein_coding;locus_tag=Rv3685c
AL123456.3	EMBL	CDS	4127295	4128725	.	-	0	ID=cds-CCP46509.1;Parent=gene-Rv3685c;Dbxref=EnsemblGenomes-Gn:Rv3685c,EnsemblGenomes-Tr:CCP46509,GOA:P9WPM5,InterPro:IPR001128,InterPro:IPR002401,InterPro:IPR017972,NCBI_GP:CCP46509.1;Name=CCP46509.1;Note=Rv3685c%2C (MTV025.033c)%2C len: 476 aa. Probable cyp137%2C cytochrome P-450%2C similar to many e.g. Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila melanogaster (Fruit fly) (495 aa)%2C FASTA scores: opt: 376%2CE(): 1.2e-15%2C (28.35%25 identity in 413 aa overlap)%3B Q59163|CYP110A2 from Anabaena variabilis (459 aa) FASTA scores: opt: 320%2C E(): 3.1e-12%2C (31.4%25 identity in 411 aa overlap)%3B O23051|C883_ARATH from Arabidopsis thaliana (Mouse-ear cress) (490 aa)%2C FASTA scores: opt: 313%2C E(): 8.8e-12%2C (28.25%25 identity in 425 aa overlap)%3B etc. Also similar to many from Mycobacterium tuberculosis e.g. O53765|C13B_MYCTU|CYP135B1|Rv0568|MT0594|MTV039.06 (472 aa)%2C FASTA scores: opt: 920%2C E(): 4.6e-49%2C (36.25%25 identity in 447 aa overlap)%3B P96813|C138_MYCTU|CYP138|Rv0136|MT0144|MTCI5.10 (441 aa) FASTA scores: opt: 886%2C E(): 5.3e-47%2C (35.5%25 identity in 445 aa overlap)%3B etc. Belongs to the cytochrome P450 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cyp137;locus_tag=Rv3685c;product=Probable cytochrome P450 137 Cyp137;protein_id=CCP46509.1;transl_table=11
AL123456.3	EMBL	gene	4128751	4129083	.	-	.	ID=gene-Rv3686c;Name=Rv3686c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3686c
AL123456.3	EMBL	CDS	4128751	4129083	.	-	0	ID=cds-CCP46510.1;Parent=gene-Rv3686c;Dbxref=EnsemblGenomes-Gn:Rv3686c,EnsemblGenomes-Tr:CCP46510,UniProtKB/TrEMBL:O69654,NCBI_GP:CCP46510.1;Name=CCP46510.1;Note=Rv3686c%2C (MTV025.034c)%2C len: 110 aa. Hypothetical protein%2C similar to P96893|Rv3288c|MTCY71.28c hypothetical 15.2 KDA protein from Mycobacterium tuberculosis (and Mycobacterium bovis) (137 aa) FASTA scores: opt: 106%2C E(): 5.6%2C (29.1%25 identity in 79 aa overlap)%3B and a few hypothetical proteins e.g. Q9GUV6|L2259.2 from Leishmania major (360 aa) FASTA scores: opt: 118%2C E(): 2.1%2C (28.7%25 identity in 101 aa overlap). Equivalent to AAK48155 from Mycobacterium tuberculosis strain CDC1551 (166 aa) but shorter 56 aa.;gbkey=CDS;locus_tag=Rv3686c;product=Conserved hypothetical protein;protein_id=CCP46510.1;transl_table=11
AL123456.3	EMBL	gene	4129323	4129691	.	-	.	ID=gene-Rv3687c;Name=rsfB;gbkey=Gene;gene=rsfB;gene_biotype=protein_coding;locus_tag=Rv3687c
AL123456.3	EMBL	CDS	4129323	4129691	.	-	0	ID=cds-CCP46511.1;Parent=gene-Rv3687c;Dbxref=EnsemblGenomes-Gn:Rv3687c,EnsemblGenomes-Tr:CCP46511,GOA:P9WGE1,InterPro:IPR002645,InterPro:IPR003658,NCBI_GP:CCP46511.1;Name=CCP46511.1;Note=Rv3687c%2C (MTV025.035c)%2C len: 122 aa. RsfB%2Canti-anti-sigma factor (see citation below)%2C showing some similarity to sporulation proteins and sigma-factor genes e.g. Q9WVX8|RSBV_STRCO|bldg|SCH5.12c anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa) FASTA scores: opt: 163%2C E(): 0.0007%2C (31.15%25 identity in 106 aa overlap)%3B Q9F3A2|SC5F1.27c putative anti-sigma factor antagonist from Streptomyces coelicolor (114 aa) FASTA scores: opt: 159%2C E(): 0.0013%2C (29.8%25 identity in 104 aa overlap)%3B P73609|SLR1859 hypothetical 12.0 KDA protein from Synechocystis sp. strain PCC 6803 (108 aa) FASTA scores: opt: 152%2C E(): 0.0034%2C (32.2%25 identity in 90 aa overlap)%3B L47358|BACSPOI_1 spoIIA a from Paenibacillus polymyxa (117 aa)%2C FASTA scores: opt: 107%2C E(): 0.23%2C (24.8%25 identity in 113 aa overlap)%3B SQSIGB_4 rsbU%2C rsbV%2C rsbW %26 sigB genes from Steptomyces aureus (108 aa) (28.3%25 identity in 60 aa overlap)%3B etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. MTCY180_14 and MTCY441 _8.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rsfB;locus_tag=Rv3687c;product=Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B);protein_id=CCP46511.1;transl_table=11
AL123456.3	EMBL	gene	4129893	4130357	.	-	.	ID=gene-Rv3688c;Name=Rv3688c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3688c
AL123456.3	EMBL	CDS	4129893	4130357	.	-	0	ID=cds-CCP46512.1;Parent=gene-Rv3688c;Dbxref=EnsemblGenomes-Gn:Rv3688c,EnsemblGenomes-Tr:CCP46512,GOA:I6X831,InterPro:IPR003789,InterPro:IPR019004,InterPro:IPR023168,UniProtKB/TrEMBL:I6X831,NCBI_GP:CCP46512.1;Name=CCP46512.1;Note=Rv3688c%2C (MTV025.036c)%2C len: 154 aa. Conserved protein%2C similar to other bacterial hypothetical proteins e.g. Q9X934|SCH66.02c from Streptomyces coelicolor (154 aa)%2C FASTA scores: opt: 425%2C E(): 3.4e-19%2C (46.1%25 identity in 154 aa overlap)%3B Q9WZF4|TM0690 from Thermotoga maritima (149 aa)%2C FASTA scores: opt: 326%2C E(): 3.4e-13%2C (40.4%25 identity in 151 aa overlap)%3B Q9PHU3|CJ0573 from Campylobacter jejuni (147 aa)%2C FASTA scores: opt:290 %2C E(): 5.1e-11%2C (36.4%25 identity in 151 aa overlap)%3B etc. Also some similarity to upstream O69654|Rv3686c|MTV025.034c conserved hypothetical protein from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3688c;product=Conserved protein;protein_id=CCP46512.1;transl_table=11
AL123456.3	EMBL	gene	4130357	4131712	.	+	.	ID=gene-Rv3689;Name=Rv3689;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3689
AL123456.3	EMBL	CDS	4130357	4131712	.	+	0	ID=cds-CCP46513.1;Parent=gene-Rv3689;Dbxref=EnsemblGenomes-Gn:Rv3689,EnsemblGenomes-Tr:CCP46513,GOA:I6YCR8,UniProtKB/TrEMBL:I6YCR8,NCBI_GP:CCP46513.1;Name=CCP46513.1;Note=Rv3689%2C (MTV025.037)%2C len: 451 aa. Probable conserved transmembrane protein%2C with Proline rich N-terminus%2C similar to Q9KYW6|SCE33.17 putative integral membrane protein from Streptomyces coelicolor (462 aa) FASTA scores: opt: 730%2C E(): 2.7e-21%2C (38.1%25 identity in 412 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3689;product=Probable conserved transmembrane protein;protein_id=CCP46513.1;transl_table=11
AL123456.3	EMBL	gene	4131739	4132392	.	+	.	ID=gene-Rv3690;Name=Rv3690;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3690
AL123456.3	EMBL	CDS	4131739	4132392	.	+	0	ID=cds-CCP46514.1;Parent=gene-Rv3690;Dbxref=EnsemblGenomes-Gn:Rv3690,EnsemblGenomes-Tr:CCP46514,GOA:O69658,InterPro:IPR025403,UniProtKB/TrEMBL:O69658,NCBI_GP:CCP46514.1;Name=CCP46514.1;Note=Rv3690%2C (MTV025.038)%2C len: 217 aa. Probable conserved membrane protein%2C similar to Q9KYW5|SCE33.18 putative integral membrane protein from Streptomyces coelicolor (231 aa)%2C FASTA scores: opt: 419%2C E(): 1.5e-19%2C(36.0%25 identity in 211 aa overlap). Equivalent to AAK48159 from Mycobacterium tuberculosis strain CDC1551 (233 aa) but shorter 16 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3690;product=Probable conserved membrane protein;protein_id=CCP46514.1;transl_table=11
AL123456.3	EMBL	gene	4132518	4133519	.	+	.	ID=gene-Rv3691;Name=Rv3691;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3691
AL123456.3	EMBL	CDS	4132518	4133519	.	+	0	ID=cds-CCP46515.1;Parent=gene-Rv3691;Dbxref=EnsemblGenomes-Gn:Rv3691,EnsemblGenomes-Tr:CCP46515,GOA:O69659,InterPro:IPR025646,NCBI_GP:CCP46515.1;Name=CCP46515.1;Note=Rv3691%2C (MTV025.039)%2C len: 333 aa. Conserved protein%2C similar to Q9KYW4|SCE33.19 putative secreted protein from Streptomyces coelicolor (387 aa) FASTA scores: opt: 481%2C E(): 6e-23%2C (36.6%25 identity in 358 aa overlap). Equivalent to AAK48160 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 48 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3691;product=Conserved protein;protein_id=CCP46515.1;transl_table=11
AL123456.3	EMBL	gene	4133516	4134592	.	+	.	ID=gene-Rv3692;Name=moxR2;gbkey=Gene;gene=moxR2;gene_biotype=protein_coding;locus_tag=Rv3692
AL123456.3	EMBL	CDS	4133516	4134592	.	+	0	ID=cds-CCP46516.1;Parent=gene-Rv3692;Dbxref=EnsemblGenomes-Gn:Rv3692,EnsemblGenomes-Tr:CCP46516,GOA:I6YGX9,InterPro:IPR011703,InterPro:IPR016366,InterPro:IPR027417,UniProtKB/TrEMBL:I6YGX9,NCBI_GP:CCP46516.1;Name=CCP46516.1;Note=Rv3692%2C (MTV025.040)%2C len: 358 aa. Probable moxR2%2Cmethanol dehydrogenase regulatory protein%2C highly similar (generally longer at N-terminus) to Q9KYW3|SCE33.20 putative regulatory protein from Streptomyces coelicolor (329 aa)%2C FASTA scores: opt: 1523%2C E(): 4.2e-74%2C (70.9%25 identity in 330 aa overlap)%3B Q9Z538|SC9B2.21c putative regulatory protein from Streptomyces coelicolor (332 aa) FASTA scores: opt: 1008%2C E(): 1.1e-46%2C (50.8%25 identity in 313 aa overlap)%3B Q9UZ67|MOXR-3|PAB0848 methanol dehydrogenase regulatory protein from Pyrococcus abyssi (314 aa)%2C FASTA scores: opt: 989%2C E(): 1.1e-45%2C (50.65%25 identity in 302 aa overlap)%3B Q9AAN1|CC0566 MOXR protein from Caulobacter crescentus (323 aa)%2C FASTA scores: opt: 988%2C E(): 1.3e-45%2C (52.3%25 identity in 306 aa overlap)%3B etc. Also similar to O53170|MTV007.26|MOXR|Rv1479 from Mycobacterium tuberculosis (377 aa)%3B and O07392|AF002133_6|MOXR from Mycobacterium avium (309 aa). Also high similarity with several hypothetical bacterial proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=moxR2;locus_tag=Rv3692;product=Probable methanol dehydrogenase transcriptional regulatory protein MoxR2;protein_id=CCP46516.1;transl_table=11
AL123456.3	EMBL	repeat_region	4134601	4134725	.	+	.	ID=id-AL123456.3:4134601..4134725;Note=125 bp Mycobacterial Interspersed Repetitive Unit%2CClass III.;gbkey=repeat_region
AL123456.3	EMBL	gene	4134726	4136048	.	+	.	ID=gene-Rv3693;Name=Rv3693;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3693
AL123456.3	EMBL	CDS	4134726	4136048	.	+	0	ID=cds-CCP46517.1;Parent=gene-Rv3693;Dbxref=EnsemblGenomes-Gn:Rv3693,EnsemblGenomes-Tr:CCP46517,GOA:O69661,InterPro:IPR002881,UniProtKB/TrEMBL:O69661,NCBI_GP:CCP46517.1;Name=CCP46517.1;Note=Rv3693%2C (MTV025.041)%2C len: 440 aa (alternative start at 41910). Possible conserved membrane protein%2C similar to Q9KYW2|SCE33.21 putative lipoprotein from Streptomyces coelicolor (436 aa)%2C FASTA scores: opt: 875%2C E(): 3.3e-46%2C(56.25%25 identity in 448 aa overlap)%3B Q9AAN0|CC0567 hypothetical protein from Caulobacter crescentus (437 aa)%2CFASTA scores: opt: 355%2C E(): 2.3e-14%2C (30.9%25 identity in 450 aa overlap)%3B P73233|SLR2013 hypothetical 48.5 KDA protein from Synechocystis sp. strain PCC 6803 (435 aa)%2CFASTA scores: opt: 340%2C E(): 1.9e-13%2C (29.7%25 identity in 438 aa overlap)%3B etc. Equivalent to AAK48162 from Mycobacterium tuberculosis strain CDC1551 (475 aa) but shorter 35 aa. Also similar to other hypothetical proteins from Mycobacterium tuberculosis%3B MTV014_7%3B MTV007_27%3B and MTCY71_36 M. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3693;product=Possible conserved membrane protein;protein_id=CCP46517.1;transl_table=11
AL123456.3	EMBL	gene	4136122	4137114	.	-	.	ID=gene-Rv3694c;Name=Rv3694c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3694c
AL123456.3	EMBL	CDS	4136122	4137114	.	-	0	ID=cds-CCP46518.1;Parent=gene-Rv3694c;Dbxref=EnsemblGenomes-Gn:Rv3694c,EnsemblGenomes-Tr:CCP46518,GOA:O69662,InterPro:IPR002798,UniProtKB/TrEMBL:O69662,NCBI_GP:CCP46518.1;Name=CCP46518.1;Note=Rv3694c%2C (MTV025.042c)%2C len: 330 aa. Possible conserved transmembrane protein%2C highly similar to Q9KZM4|SCE34.01c putative integral membrane protein from Streptomyces coelicolor (335 aa)%2C FASTA scores: opt: 1113%2CE(): 2.5e-60%2C (51.5%25 identity in 334 aa overlap)%3B and similar to Q9KEW6|BH0733 hypothetical protein from Bacillus halodurans (355 aa)%2C FASTA scores: opt: 381%2C E(): 6.1e-16%2C(24.15%25 identity in 331 aa overlap)%3B Q9AAM9|CC0568 hypothetical protein from Caulobacter crescentus (332 aa)%2CFASTA scores: opt: 352%2C E(): 3.3e-14%2C (30.3%25 identity in 310 aa overlap)%3B P74166|SLR1478 hypothetical 35.4 KDA protein from Synechocystis sp. strain PCC 6803 (317 aa)%2CFASTA scores: opt: 330%2C E(): 6.8e-13%2C (25.65%25 identity in 308 aa overlap)%3B etc. C-terminal end shows similarity to O29631|AF0624|AE001061_10 conserved hypothetical protein (putative nifU protein) from Archaeoglobus fulgidus (185 aa)%2C FASTA scores: opt: 154%2C E(): 0.021%2C (29.0%25 identity in 131 aa overlap). Equivalent to AAK48163 from Mycobacterium tuberculosis strain CDC1551 (395 aa) but shorter 65 aa. Also some similarity to MTCY428_20 hypothetical 43.7 KDA protein from Mycobacterium tuberculosis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3694c;product=Possible conserved transmembrane protein;protein_id=CCP46518.1;transl_table=11
AL123456.3	EMBL	gene	4137206	4138138	.	+	.	ID=gene-Rv3695;Name=Rv3695;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3695
AL123456.3	EMBL	CDS	4137206	4138138	.	+	0	ID=cds-CCP46519.1;Parent=gene-Rv3695;Dbxref=EnsemblGenomes-Gn:Rv3695,EnsemblGenomes-Tr:CCP46519,InterPro:IPR010432,UniProtKB/TrEMBL:O69663,NCBI_GP:CCP46519.1;Name=CCP46519.1;Note=Rv3695%2C (MTV025.043)%2C len: 310 aa. Possible conserved membrane protein%2C equivalent%2C but longer 88 aa%2Cto Q9CB83|ML2312 possible membrane protein from Mycobacterium leprae (196 aa)%2C FASTA scores: opt: 898%2C E(): 5.2e-36%2C (71.05%25 identity in 190 aa overlap). Also highly similar to Q9KZM3|SCE34.02 putative integral membrane protein from Streptomyces coelicolor (318 aa)%2C FASTA scores: opt: 740%2CE(): 2.4e-28%2C (43.25%25 identity in 319 aa overlap)%3B and similar to P72718|SLR0254 hypothetical 30.4 KDA protein from Synechocystis sp. strain PCC 6803 (266 aa)%2C FASTA scores: opt: 287%2C E(): 6.1e-07%2C (29.6%25 identity in 260 aa overlap)%3B Q9HW83|PA4318 hypothetical protein from Pseudomonas aeruginosa (265 aa)%2C FASTA scores: opt: 250%2CE(): 3.5e-05%2C (32.0%25 identity in 203 aa overlap)%3B Q9KEW5|BH0734 hypothetical protein from Bacillus halodurans (266 aa)%2C FASTA scores: opt: 168%2C E(): 0.0047%2C (25.95%25 identity in 231 aa overlap)%3B etc. C-terminal end shows some similarity to proline-rich proteins e.g. Q62106 proline-rich salivary protein (fragment) from Mus musculus (Mouse) (188 aa) (36.1%25 identity in 97 aa overlap). Equivalent to AAK48164 from Mycobacterium tuberculosis strain CDC1551 (269 aa) but longer 41 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3695;product=Possible conserved membrane protein;protein_id=CCP46519.1;transl_table=11
AL123456.3	EMBL	gene	4138202	4139755	.	-	.	ID=gene-Rv3696c;Name=glpK;gbkey=Gene;gene=glpK;gene_biotype=protein_coding;locus_tag=Rv3696c
AL123456.3	EMBL	CDS	4138202	4139755	.	-	0	ID=cds-CCP46520.1;Parent=gene-Rv3696c;Dbxref=EnsemblGenomes-Gn:Rv3696c,EnsemblGenomes-Tr:CCP46520,GOA:P9WPK1,InterPro:IPR005999,InterPro:IPR018483,InterPro:IPR018484,InterPro:IPR018485,NCBI_GP:CCP46520.1;Name=CCP46520.1;Note=Rv3696c%2C (MTV025.044c)%2C len: 517 aa. Probable glpK%2Cglycerol kinase%2C equivalent to Q9CB81|GLPK_MYCLE|ML2314 glycerol kinase from Mycobacterium leprae (508 aa)%2C FASTA scores: opt: 3120%2C E(): 4.7e-189%2C (91.35%25 identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa)%2C FASTA scores: opt: 2606%2C E(): 1.1e-156%2C (75.35%25 identity in 503 aa overlap)%3B Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002%2C E(): 1.3e-118%2C (59.05%25 identity in 503 aa overlap)%3B Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa)%2C FASTA scores: opt: 1838%2C E(): 2.7e-108%2C(54.8%25 identity in 498 aa overlap)%3B P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa)%2C FASTA scores: opt: 1740%2C E(): 4.1e-102%2C (52.3%25 identity in 499 aa overlap)%3B etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1%2C PS00070 Aldehyde dehydrogenases cysteine active site%2C PS00445 FGGY family of carbohydrate kinases signature 2. Belongs to the fucokinase / gluconokinase / glycerokinase / xylulokinase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glpK;inference=protein motif:PROSITE:PS00933;locus_tag=Rv3696c;product=Probable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK);protein_id=CCP46520.1;transl_table=11
AL123456.3	EMBL	gene	4139805	4140242	.	-	.	ID=gene-Rv3697c;Name=vapC48;gbkey=Gene;gene=vapC48;gene_biotype=protein_coding;locus_tag=Rv3697c
AL123456.3	EMBL	CDS	4139805	4140242	.	-	0	ID=cds-CCP46521.1;Parent=gene-Rv3697c;Dbxref=EnsemblGenomes-Gn:Rv3697c,EnsemblGenomes-Tr:CCP46521,GOA:P9WF47,InterPro:IPR002716,InterPro:IPR006226,InterPro:IPR022907,InterPro:IPR029060,NCBI_GP:CCP46521.1;Name=CCP46521.1;Note=Rv3697c%2C (MTV025.045c)%2C len: 145 aa. Possible vapC48%2C toxin%2C part of toxin-antitoxin (TA) operon with Rv3697A%2C contains PIN domain%2C see Arcus et al. 2005. Similar to many others in Mycobacterium tuberculosis e.g. Q10800|YS72_MYCTU|Rv2872|MT2939|MTCY274.03 (147 aa) FASTA scores: opt: 223%2C E(): 7.3e-08%2C (32.6%25 identity in 141 aa overlap)%3B O53501|Rv2103c|MTV020.03 (144 aa)%2C FASTA scores: opt: 215%2C E(): 2.4e-07%2C (31.4%25 identity in 137 aa overlap)%3B O53812|Rv0749|MTV041.23 (142 aa)%2C FASTA scores: opt: 192%2CE(): 7.6e-06%2C (31.25%25 identity in 144 aa overlap)%3B etc.;gbkey=CDS;gene=vapC48;locus_tag=Rv3697c;product=Possible toxin VapC48. Contains PIN domain.;protein_id=CCP46521.1;transl_table=11
AL123456.3	EMBL	gene	4140239	4140463	.	-	.	ID=gene-Rv3697A;Name=vapB48;gbkey=Gene;gene=vapB48;gene_biotype=protein_coding;locus_tag=Rv3697A
AL123456.3	EMBL	CDS	4140239	4140463	.	-	0	ID=cds-CCP46522.1;Parent=gene-Rv3697A;Dbxref=EnsemblGenomes-Gn:Rv3697A,EnsemblGenomes-Tr:CCP46522,NCBI_GP:CCP46522.1;Name=CCP46522.1;Note=Rv3697A%2C len: 74 aa. Possible vapB48%2C antitoxin%2Cpart of toxin-antitoxin (TA) operon with Rv3697c%2C see Arcus et al. 2005. Similar to others in M. tuberculosis e.g. Rv3321c%2C Rv0748;gbkey=CDS;gene=vapB48;locus_tag=Rv3697A;product=Possible antitoxin VapB48;protein_id=CCP46522.1;transl_table=11
AL123456.3	EMBL	gene	4140493	4142022	.	+	.	ID=gene-Rv3698;Name=Rv3698;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3698
AL123456.3	EMBL	CDS	4140493	4142022	.	+	0	ID=cds-CCP46523.1;Parent=gene-Rv3698;Dbxref=EnsemblGenomes-Gn:Rv3698,EnsemblGenomes-Tr:CCP46523,InterPro:IPR016602,UniProtKB/TrEMBL:I6YCS6,NCBI_GP:CCP46523.1;Name=CCP46523.1;Note=Rv3698%2C (MTV025.046)%2C len: 509 aa. Conserved protein%2C highly similar to Q9AK89|SC10A9.15c conserved hypothetical protein from Streptomyces coelicolor (505 aa)%2CFASTA scores: opt: 1720%2C E(): 9e-103%2C (53.65%25 identity in 494 aa overlap). N-terminal end highly similar to CAC42136|SCBAC25F8.01 conserved hypothetical protein (fragment) from Streptomyces coelicolor (291 aa)%2C FASTA scores: opt: 1078%2C E(): 8.7e-62%2C (52.6%25 identity in 291 aa overlap)%3B and C-terminus highly similar to CAC44687|SCBAC17A6.42c (235 aa)%2C FASTA scores: opt: 911%2CE(): 3.8e-51%2C (57.25%25 identity in 234 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3698;product=Conserved protein;protein_id=CCP46523.1;transl_table=11
AL123456.3	EMBL	gene	4142044	4142745	.	+	.	ID=gene-Rv3699;Name=Rv3699;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3699
AL123456.3	EMBL	CDS	4142044	4142745	.	+	0	ID=cds-CCP46524.1;Parent=gene-Rv3699;Dbxref=EnsemblGenomes-Gn:Rv3699,EnsemblGenomes-Tr:CCP46524,GOA:O69667,InterPro:IPR008854,InterPro:IPR029063,UniProtKB/TrEMBL:O69667,NCBI_GP:CCP46524.1;Name=CCP46524.1;Note=Rv3699%2C (MTV025.047)%2C len: 233 aa. Conserved protein%2C showing similarity with hypothetical proteins e.g. Q9P3V6|SPAC1348.04 (alias Q9P3E7|SPAC750.03c or Q9P7U5|SPAC977.03) from Schizosaccharomyces pombe (Fission yeast) (145 aa)%2C FASTA scores: opt: 188%2C E(): 7.5e-05%2C(31.65%25 identity in 120 aa overlap)%3B and Q9KB70|BH2058 from Bacillus halodurans (241 aa) FASTA scores: opt: 185%2C E(): 0.00018%2C (27.8%25 identity in 162 aa overlap)%3B Q9XA90|SCF43A.25c putative methyltransferase from Streptomyces coelicolor (215 aa)%2C FASTA scores: opt: 166%2CE(): 0.0025%2C (29.95%25 identity in 147 aa overlap)%3B etc. Also highly similar to O06426|Rv0560c|MTCY25D10.39c hypothetical 25.9 KDA protein from Mycobacterium tuberculosis (241 aa)%2CFASTA scores: opt: 690%2C E(): 6.5e-36%2C (53.4%25 identity in 234 aa overlap)%3B and similar to other hypothetical proteins from Mycobacterium tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c (212 aa) FASTA scores: opt: 378%2C E(): 1.5e-16%2C (35.4%25 identity in 192 aa overlap)%3B P71972|Rv2675c|MTCY441.44c (250 aa) FASTA scores: opt: 297%2CE(): 2e-11%2C (31.1%25 identity in 193 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3699;product=Conserved protein;protein_id=CCP46524.1;transl_table=11
AL123456.3	EMBL	gene	4142748	4143920	.	-	.	ID=gene-Rv3700c;Name=Rv3700c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3700c
AL123456.3	EMBL	CDS	4142748	4143920	.	-	0	ID=cds-CCP46525.1;Parent=gene-Rv3700c;Dbxref=EnsemblGenomes-Gn:Rv3700c,EnsemblGenomes-Tr:CCP46525,GOA:O69668,InterPro:IPR000192,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR027563,NCBI_GP:CCP46525.1;Name=CCP46525.1;Note=Rv3700c%2C (MTV025.048c)%2C len: 390 aa. Conserved hypothetical protein%3B could be a transferase or a lyase. Indeed%2C similar to various enzymes e.g. Q53824|CAC capreomycin acetyltransferase from Streptomyces capreolus (359 aa)%2C FASTA scores: opt: 338%2C E(): 1.1e-12%2C (33.35%25 identity in 363 aa overlap)%3B Q9HXX3|CSD_PSEAE|PA3667 probable cysteine desulfurase from Pseudomonas aeruginosa (401 aa) FASTA scores: opt: 260%2C E(): 4.8e-08%2C (30.2%25 identity in 404 aa overlap)%3B Q9X815|SC6G10.30 putative aminotransferase from Streptomyces coelicolor (460 aa)%2CFASTA scores: opt: 243%2C E(): 5.4e-07%2C (29.15%25 identity in 374 aa overlap)%3B Q9A761|CC1865 aminotransferase class V from Caulobacter crescentus (379 aa)%2C FASTA scores: opt: 234%2C E(): 1.6e-06%2C (27.95%25 identity in 383 aa overlap)%3B O74351|NFS1_SCHPO|SPBC21D10.11c probable cysteine desulfurase from Schizosaccharomyces pombe (Fission yeast) (498 aa)%2C FASTA scores: opt: 232%2C E(): 2.5e-06%2C (29.1%25 identity in 285 aa overlap)%3B Q9RME8|NIFS NIFS protein (cysteine desulfurase%2C tRNA splicing protein) from Zymomonas mobilis (370 aa)%2C FASTA scores: opt: 230%2C E(): 2.6e-06%2C (32.85%25 identity in 201 aa overlap)%3B etc. Contains PS00626 Regulator of chromosome condensation (RCC1) signature 2.;gbkey=CDS;inference=protein motif:PROSITE:PS00626;locus_tag=Rv3700c;product=Conserved hypothetical protein;protein_id=CCP46525.1;transl_table=11
AL123456.3	EMBL	gene	4143951	4144916	.	-	.	ID=gene-Rv3701c;Name=Rv3701c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3701c
AL123456.3	EMBL	CDS	4143951	4144916	.	-	0	ID=cds-CCP46526.1;Parent=gene-Rv3701c;Dbxref=EnsemblGenomes-Gn:Rv3701c,EnsemblGenomes-Tr:CCP46526,GOA:P9WN47,InterPro:IPR017804,InterPro:IPR019257,InterPro:IPR029063,NCBI_GP:CCP46526.1;Name=CCP46526.1;Note=Rv3701c%2C (MTV025.049c)%2C len: 321 aa. Conserved hypothetical protein%2C highly similar to other hypothetical proteins e.g. Q9RCZ8|SCM1.46 from Streptomyces coelicolor (251 aa)%2C FASTA scores: opt: 897%2C E(): 1.1e-50%2C (59.9%25 identity in 242 aa overlap)%3B P73759|SLR0865 from Synechocystis sp. strain PCC 6803 (337 aa)%2C FASTA scores: opt: 779%2C E(): 5.7e-43%2C (40.35%25 identity in 327 aa overlap)%3B Q9GWA1|LM12.997 from Leishmania major (383 aa) FASTA scores: opt: 616%2C E(): 2.1e-32%2C (39.05%25 identity in 297 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3701c;product=Conserved hypothetical protein;protein_id=CCP46526.1;transl_table=11
AL123456.3	EMBL	gene	4144913	4145614	.	-	.	ID=gene-Rv3702c;Name=Rv3702c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3702c
AL123456.3	EMBL	CDS	4144913	4145614	.	-	0	ID=cds-CCP46527.1;Parent=gene-Rv3702c;Dbxref=EnsemblGenomes-Gn:Rv3702c,EnsemblGenomes-Tr:CCP46527,GOA:O69670,InterPro:IPR017808,InterPro:IPR017932,InterPro:IPR029055,NCBI_GP:CCP46527.1;Name=CCP46527.1;Note=Rv3702c%2C (MTV025.050c)%2C len: 233 aa. Conserved hypothetical protein%2C highly similar to other hypothetical proteins Q9RCZ9|SCM1.45 from Streptomyces coelicolor (271 aa)%2C FASTA scores: opt: 383%2C E(): 2.3e-17%2C (44.85%25 identity in 252 aa overlap)%3B and P54004|Y199_SYNY3|SLR0199 from Synechocystis sp. strain PCC 6803 (304 aa)%2C FASTA scores: opt: 292%2C E(): 1.7e-11%2C (30.05%25 identity in 263 aa overlap)%3B and similar to others e.g. Q9KMU4|VCA0225 from Vibrio cholerae (254 aa)%2C FASTA scores: opt: 260%2C E(): 1.6e-09%2C (29.8%25 identity in 245 aa overlap). Equivalent to AAK48172 from Mycobacterium tuberculosis strain CDC1551 (194 aa) but longer 39 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3702c;product=Conserved hypothetical protein;protein_id=CCP46527.1;transl_table=11
AL123456.3	EMBL	gene	4145614	4146891	.	-	.	ID=gene-Rv3703c;Name=Rv3703c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3703c
AL123456.3	EMBL	CDS	4145614	4146891	.	-	0	ID=cds-CCP46528.1;Parent=gene-Rv3703c;Dbxref=EnsemblGenomes-Gn:Rv3703c,EnsemblGenomes-Tr:CCP46528,GOA:O69671,InterPro:IPR005532,InterPro:IPR016187,InterPro:IPR017806,InterPro:IPR024775,NCBI_GP:CCP46528.1;Name=CCP46528.1;Note=Rv3703c%2C (MTV025.051c)%2C len: 425 aa. Conserved hypothetical protein%2C similar to other hypothetical proteins e.g. Q9RD00|SCM1.44 from Streptomyces coelicolor (446 aa)%2C FASTA scores: opt: 1480%2C E(): 1.4e-85%2C (53.9%25 identity in 421 aa overlap)%3B P72841|SLR1303 from Synechocystis sp. strain PCC 6803 (410 aa)%2C FASTA scores: opt: 533%2C E(): 4.5e-26%2C (36.6%25 identity in 429 aa overlap)%3B Q9KYH7|SCC61A.16 from Streptomyces coelicolor (256 aa)%2CFASTA scores: opt: 266%2C E(): 1.9e-09%2C (32.25%25 identity in 248 aa overlap)%3B etc. Also similar to P95060|Rv0712|MTCY210.31 hypothetical 32.7 KDA protein from Mycobacterium tuberculosis (299 aa)%2C FASTA scores: opt: 243%2C E(): 5.9e-08%2C (30.6%25 identity in 304 aa overlap).;gbkey=CDS;locus_tag=Rv3703c;product=Conserved hypothetical protein;protein_id=CCP46528.1;transl_table=11
AL123456.3	EMBL	gene	4146888	4148186	.	-	.	ID=gene-Rv3704c;Name=gshA;gbkey=Gene;gene=gshA;gene_biotype=protein_coding;locus_tag=Rv3704c
AL123456.3	EMBL	CDS	4146888	4148186	.	-	0	ID=cds-CCP46529.1;Parent=gene-Rv3704c;Dbxref=EnsemblGenomes-Gn:Rv3704c,EnsemblGenomes-Tr:CCP46529,GOA:P9WPK7,InterPro:IPR006336,InterPro:IPR017809,NCBI_GP:CCP46529.1;Name=CCP46529.1;Note=Rv3704c%2C (MTV025.052c)%2C len: 432 aa. Possible gshA%2Cglutamate--cysteine ligase%2C similar to many e.g. Q9A2Z2|CC3414 glutamate--cysteine ligase from Caulobacter crescentus (453 aa)%2C FASTA scores: opt: 404%2C E(): 5.9e-17%2C(30.45%25 identity in 312 aa overlap)%3B Q9SEH0|GSH1 gamma-glutamylcysteinyl synthetase precursor from Pisum sativum (Garden pea) (499 aa)%2C FASTA scores: opt: 400%2C E(): 1.1e-16%2C (26.4%25 identity in 439 aa overlap)%3B Q9RH09|GSH gamma-glutamylcysteine synthetase from Zymomonas mobilis (462 aa)%2C FASTA scores: opt: 397%2C E(): 1.6e-16%2C (28.95%25 identity in 304 aa overlap)%3B P46309|GSH1_ARATH|GSH1|AT4G23100|F7H19.290 glutamate--cysteine ligase from Arabidopsis thaliana (Mouse-ear cress) (522 aa)%2C FASTA scores: opt: 395%2C E(): 2.3e-16%2C (27.25%25 identity in 385 aa overlap)%3B etc. But note that this putative protein is also similar to Q9JMV4|GSHA putative glutathione synthetase (fragment) from Bradyrhizobium japonicum (460 aa)%2C FASTA scores: opt: 498%2CE(): 1.3e-22%2C (33.35%25 identity in 333 aa overlap) (no significant publications found (August 2001)). Nucleotide position 4147070 in the genome sequence has been corrected%2CA:G resulting in L373L.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gshA;locus_tag=Rv3704c;product=Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase);protein_id=CCP46529.1;transl_table=11
AL123456.3	EMBL	gene	4148318	4148962	.	-	.	ID=gene-Rv3705c;Name=Rv3705c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3705c
AL123456.3	EMBL	CDS	4148318	4148962	.	-	0	ID=cds-CCP46530.1;Parent=gene-Rv3705c;Dbxref=EnsemblGenomes-Gn:Rv3705c,EnsemblGenomes-Tr:CCP46530,InterPro:IPR026954,UniProtKB/TrEMBL:I6XI06,NCBI_GP:CCP46530.1;Name=CCP46530.1;Note=Rv3705c%2C (MTV025.053c)%2C len: 214 aa. Conserved protein%2C equivalent to Q9CB80|ML2320 hypothetical protein from Mycobacterium leprae (215 aa) FASTA scores: opt: 1145%2CE(): 5.9e-68%2C (79.45%25 identity in 214 aa overlap). Some similarity to the C-terminal end of Q11053|PKNH_MYCTU|Rv1266c|MT1304|MTCY50.16 probable serine/threonine-protein from Mycobacterium tuberculosis (626 aa)%2C FASTA scores: opt: 175%2C E(): 0.0005%2C (24.9%25 identity in 201 aa overlap)%3B and to the N-terminal end of P23903|E13B_BACCI|GLCA glucan endo-1%2C3-beta-glucosidase A1 precursor from Bacillus circulans (682 aa)%2C FASTA scores: opt: 122%2C E(): 1.6%2C (25.6%25 identity in 164 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3705c;product=Conserved protein;protein_id=CCP46530.1;transl_table=11
AL123456.3	EMBL	gene	4149091	4149480	.	-	.	ID=gene-Rv3705A;Name=Rv3705A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3705A
AL123456.3	EMBL	CDS	4149091	4149480	.	-	0	ID=cds-CCP46531.1;Parent=gene-Rv3705A;Dbxref=EnsemblGenomes-Gn:Rv3705A,EnsemblGenomes-Tr:CCP46531,UniProtKB/TrEMBL:I6YGY9,NCBI_GP:CCP46531.1;Name=CCP46531.1;Note=Rv3705A%2C len: 129 aa. Conserved hypothetical protein%2C similar to downstream ORF O69674|Rv3706c|MTV025.054c conserved hypothetical proline rich protein from Mycobacterium tuberculosis (106 aa)%2CFASTA scores: opt: 245%2C E(): 0.00013%2C (40.7%25 identity in 113 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3705A;product=Conserved hypothetical proline rich protein;protein_id=CCP46531.1;transl_table=11
AL123456.3	EMBL	gene	4149591	4149911	.	-	.	ID=gene-Rv3706c;Name=Rv3706c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3706c
AL123456.3	EMBL	CDS	4149591	4149911	.	-	0	ID=cds-CCP46532.1;Parent=gene-Rv3706c;Dbxref=EnsemblGenomes-Gn:Rv3706c,EnsemblGenomes-Tr:CCP46532,UniProtKB/TrEMBL:I6X849,NCBI_GP:CCP46532.1;Name=CCP46532.1;Note=Rv3706c%2C (MTV025.054c)%2C len: 106 aa. Conserved ypothetical pro-rich protein%2C similar to upstream ORF Rv3705A (129 aa)%2C and AAK48176|MT3808.1 hypothetical 13.0 KDA protein from Mycobacterium tuberculosis strain CDC1551 (129 aa)%2C FASTA scores: opt: 245%2C E(): 4.4e-06%2C (40.7%25 identity in 113 aa overlap).;gbkey=CDS;locus_tag=Rv3706c;product=Conserved hypothetical proline rich protein;protein_id=CCP46532.1;transl_table=11
AL123456.3	EMBL	gene	4150030	4151040	.	-	.	ID=gene-Rv3707c;Name=Rv3707c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3707c
AL123456.3	EMBL	CDS	4150030	4151040	.	-	0	ID=cds-CCP46533.1;Parent=gene-Rv3707c;Dbxref=EnsemblGenomes-Gn:Rv3707c,EnsemblGenomes-Tr:CCP46533,InterPro:IPR025442,UniProtKB/TrEMBL:I6Y4C4,NCBI_GP:CCP46533.1;Name=CCP46533.1;Note=Rv3707c%2C (MTV025.055c)%2C len: 336 aa. Equivalent to Q9CB79|ML2321 hypothetical protein from Mycobacterium leprae (336 aa)%2C FASTA scores: opt: 1948%2C E(): 6.7e-110%2C(81.95%25 identity in 332 aa overlap)%3B and P41402|YASD_MYCSM hypothetical 35.9 KDA protein in the aspartokinase gene cluster from Mycobacterium smegmatis (333 aa)%2C FASTA scores: opt: 1731%2C E(): 7.4e-97%2C (70.85%25 identity in 333 aa overlap).;gbkey=CDS;locus_tag=Rv3707c;product=Conserved hypothetical protein;protein_id=CCP46533.1;transl_table=11
AL123456.3	EMBL	gene	4151180	4152217	.	-	.	ID=gene-Rv3708c;Name=asd;gbkey=Gene;gene=asd;gene_biotype=protein_coding;locus_tag=Rv3708c
AL123456.3	EMBL	CDS	4151180	4152217	.	-	0	ID=cds-CCP46534.1;Parent=gene-Rv3708c;Dbxref=EnsemblGenomes-Gn:Rv3708c,EnsemblGenomes-Tr:CCP46534,GOA:P9WNX5,InterPro:IPR000319,InterPro:IPR000534,InterPro:IPR005986,InterPro:IPR012080,InterPro:IPR012280,InterPro:IPR016040,PDB:2GUL,PDB:3TZ6,PDB:3VOS,NCBI_GP:CCP46534.1;Name=CCP46534.1;Note=Rv3708c%2C (MTV025.056c)%2C len: 345 aa. Asd%2Caspartate-semialdehyde dehydrogenase (see citation below)%2Cequivalent to many e.g. P47730|DHAS_MYCBO|ASD from Mycobacterium bovis (345 aa) FASTA scores: opt: 2150%2C E(): 1.6e-124%2C (97.7%25 identity in 345 aa overlap)%3B or Q9JN40|ASD from Mycobacterium bovis (323 aa)%2C FASTA scores: opt: 2021%2CE(): 1.2e-116%2C (97.5%25 identity in 323 aa overlap)%3B Q9CB78|ASD|ML2322 from Mycobacterium leprae (351 aa)%2C FASTA scores: opt: 1889%2C E(): 1.6e-108%2C (84.45%25 identity in 347 aa overlap)%3B P41404|DHAS_MYCSM|ASD from Mycobacterium smegmatis (346 aa)%2C FASTA scores: opt: 1801%2C E(): 3.9e-103%2C(80.3%25 identity in 345 aa overlap)%3B etc. Contains PS01103 Aspartate-semialdehyde dehydrogenase signature. Belongs to the aspartate-semialdehyde dehydrogenase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=asd;inference=protein motif:PROSITE:PS01103;locus_tag=Rv3708c;product=Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (aspartic semialdehyde dehydrogenase) (L-aspartate-beta-semialdehyde dehydrogenase);protein_id=CCP46534.1;transl_table=11
AL123456.3	EMBL	gene	4152218	4153483	.	-	.	ID=gene-Rv3709c;Name=ask;gbkey=Gene;gene=ask;gene_biotype=protein_coding;locus_tag=Rv3709c
AL123456.3	EMBL	CDS	4152218	4153483	.	-	0	ID=cds-CCP46535.1;Parent=gene-Rv3709c;Dbxref=EnsemblGenomes-Gn:Rv3709c,EnsemblGenomes-Tr:CCP46535,GOA:P9WPX3,InterPro:IPR001048,InterPro:IPR001341,InterPro:IPR002912,InterPro:IPR005260,InterPro:IPR018042,InterPro:IPR027795,PDB:3S1T,PDB:4GO5,PDB:4GO7,NCBI_GP:CCP46535.1;Name=CCP46535.1;Note=Rv3709c%2C (MTV025.057c)%2C len: 421 aa. Ask%2Caspartokinase (see citation below)%2C equivalent to Q9CB77|ask|ML2323 from Mycobacterium leprae (421 aa)%2C FASTA scores: opt: 2531%2C E(): 2e-140%2C (92.65%25 identity in 421 aa overlap)%3B and P41403|AK_MYCSM|ask from Mycobacterium smegmatis (421 aa)%2C FASTA scores: opt: 2423%2C E(): 4e-134%2C(88.1%25 identity in 421 aa overlap)%3B and to several other organisms e.g. Q9RQ25|ASKA from Amycolatopsis mediterranei (421 aa)%2C FASTA scores: opt: 2026%2C E(): 5.8e-111%2C (72.2%25 identity in 421 aa overlap). Contains PS00324 Aspartokinase signature. Belongs to the aspartokinase family. Alternative products: the alpha and beta subunits of aspartokinase are produced by the use of alternative initiation sites (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ask;inference=protein motif:PROSITE:PS00324;locus_tag=Rv3709c;product=Aspartokinase Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha)%3B and aspartokinase beta subunit (Ask-beta)];protein_id=CCP46535.1;transl_table=11
AL123456.3	EMBL	gene	4153740	4155674	.	+	.	ID=gene-Rv3710;Name=leuA;gbkey=Gene;gene=leuA;gene_biotype=protein_coding;locus_tag=Rv3710
AL123456.3	EMBL	CDS	4153740	4155674	.	+	0	ID=cds-CCP46536.1;Parent=gene-Rv3710;Dbxref=EnsemblGenomes-Gn:Rv3710,EnsemblGenomes-Tr:CCP46536,GOA:P9WQB3,InterPro:IPR000891,InterPro:IPR002034,InterPro:IPR005668,InterPro:IPR013709,InterPro:IPR013785,PDB:1SR9,PDB:3FIG,PDB:3HPS,PDB:3HPX,PDB:3HPZ,PDB:3HQ1,PDB:3U6W,NCBI_GP:CCP46536.1;Name=CCP46536.1;Note=Rv3710%2C (MTV025.058)%2C len: 644 aa. LeuA%2Calpha-isopropylmalate synthase (see citations below)%2Cequivalent to Q9CB76|LEUA|ML2324 2-isopropylmalate synthase from Mycobacterium leprae (607 aa)%2C FASTA scores: opt: 3291%2C E(): 3.7e-192%2C (80.7%25 identity in 642 aa overlap). Also highly similar to many e.g. P42455|LEU1_CORGL|LEUA from Corynebacterium glutamicum (Brevibacterium flavum) (616 aa)%2C FASTA scores: opt: 2547%2C E(): 5.3e-147%2C (63.25%25 identity in 645 aa overlap)%3B O31046|LEU1_STRCO|LEUA from Streptomyces coelicolor (573 aa)%2C FASTA scores: opt: 2226%2CE(): 1.5e-127%2C (57.8%25 identity in 616 aa overlap)%3B BAB49833|Q98HN3|MLR2792 from Rhizobium loti (Mesorhizobium loti) (588 aa)%2C FASTA scores: opt: 1849%2C E(): 1.1e-104%2C(58.0%25 identity in 536 aa overlap)%3B etc. Equivalent to AAK48181 from Mycobacterium tuberculosis strain CDC1551 (659 aa) but shorter 15 aa. Contains PS00815 and PS00816 Alpha-isopropylmalate and homocitrate synthases signatures 1 and 2. Belongs to the alpha-IPM synthetase / homocitrate synthase family. K+ is likely the physiological activator%3B Zn2+ and Cd2+ are inhibitors.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=leuA;inference=protein motif:PROSITE:PS00816;locus_tag=Rv3710;product=2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS);protein_id=CCP46536.1;transl_table=11
AL123456.3	EMBL	gene	4155740	4156729	.	-	.	ID=gene-Rv3711c;Name=dnaQ;gbkey=Gene;gene=dnaQ;gene_biotype=protein_coding;locus_tag=Rv3711c
AL123456.3	EMBL	CDS	4155740	4156729	.	-	0	ID=cds-CCP46537.1;Parent=gene-Rv3711c;Dbxref=EnsemblGenomes-Gn:Rv3711c,EnsemblGenomes-Tr:CCP46537,GOA:O69678,InterPro:IPR001357,InterPro:IPR006055,InterPro:IPR012337,InterPro:IPR013520,UniProtKB/TrEMBL:O69678,NCBI_GP:CCP46537.1;Name=CCP46537.1;Note=Rv3711c%2C (MTV025.059c)%2C len: 329 aa. Probable dnaQ%2CDNA polymerase III%2C epsilon subunit%2C similar to many e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328 aa)%2C FASTA scores: opt: 509%2C E(): 4.2e-25%2C (41.6%25 identity in 315 aa overlap)%3B Q9JYS6|NMB1451 from Neisseria meningitidis (serogroup B) (and Q9JTR5|MA1665 from serogroup A) (470 aa)%2C FASTA scores: opt: 247%2C E(): 2.6e-08%2C (33.15%25 identity in 172 aa overlap)%3B O83649|DP3E_TREPA|DNAQ|TP0643 from Treponema pallidum (215 aa)%2C FASTA scores: opt: 240%2C E(): 3.7e-08%2C (29.65%25 identity in 162 aa overlap)%3B P03007|DP3E_ECOLI|MUTD|B0215 from Escherichia coli strain K12 (243 aa)%2C FASTA scores: opt: 208%2C E(): 4.5e-06%2C (28.4%25 identity in 169 aa overlap)%3B etc. Also similar to Q10384|YL91_MYCTU|Rv2191|MTCY190.02 from Mycobacterium tuberculosis (645 aa)%2C FASTA scores: opt: 260%2C E(): 5e-09%2C(28.55%25 identity in 301 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dnaQ;locus_tag=Rv3711c;product=Probable DNA polymerase III (epsilon subunit) DnaQ;protein_id=CCP46537.1;transl_table=11
AL123456.3	EMBL	gene	4156981	4158222	.	+	.	ID=gene-Rv3712;Name=Rv3712;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3712
AL123456.3	EMBL	CDS	4156981	4158222	.	+	0	ID=cds-CCP46538.1;Parent=gene-Rv3712;Dbxref=EnsemblGenomes-Gn:Rv3712,EnsemblGenomes-Tr:CCP46538,GOA:I6Y4C7,InterPro:IPR013221,InterPro:IPR013564,UniProtKB/TrEMBL:I6Y4C7,NCBI_GP:CCP46538.1;Name=CCP46538.1;Note=Rv3712%2C (MTV025.060)%2C len: 413 aa. Possible ligase %2Cequivalent to O69522|ML2326|MLCB2407.24c hypothetical 43.8 KDA protein (possible ligase) from Mycobacterium leprae (411 aa)%2C FASTA scores: opt: 2265%2C E(): 8e-129%2C (84.25%25 identity in 413 aa overlap). Also similar to ligases or hypothetical proteins e.g. Q9FCA1|2SCG58.12 putative ligase from Streptomyces coelicolor (412 aa)%2C FASTA scores: opt: 1168%2C E(): 6.7e-63%2C (45.8%25 identity in 406 aa overlap)%3B P74303|SLR0938 hypothetical 50.2 KDA protein from Synechocystis sp. strain PCC 6803 (459 aa)%2C FASTA scores: opt: 392%2C E(): 3.1e-16%2C (28.45%25 identity in 397 aa overlap)%3B Q99ZX1|SPY1035 putative UDP-N-acetylmuramyl tripeptide synthetase from Streptococcus pyogenes (445 aa)%2CFASTA scores: opt: 335%2C E(): 8.1e-13%2C (29.2%25 identity in 438 aa overlap)%3B Q9CGJ0|YLBD hypothetical protein from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (449 aa)%2C FASTA scores: opt: 324%2C E(): 3.8e-12%2C (28.75%25 identity in 445 aa overlap)%3B Q9ZGG7|MURC UDP-N-acetylmuramyl tripeptide synthetase from Heliobacillus mobilis (455 aa)%2C FASTA scores: opt: 292%2CE(): 3.2e-10%2C (30.75%25 identity in 449 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3712;product=Possible ligase;protein_id=CCP46538.1;transl_table=11
AL123456.3	EMBL	gene	4158227	4158922	.	+	.	ID=gene-Rv3713;Name=cobQ2;gbkey=Gene;gene=cobQ2;gene_biotype=protein_coding;locus_tag=Rv3713
AL123456.3	EMBL	CDS	4158227	4158922	.	+	0	ID=cds-CCP46539.1;Parent=gene-Rv3713;Dbxref=EnsemblGenomes-Gn:Rv3713,EnsemblGenomes-Tr:CCP46539,GOA:I6XI14,InterPro:IPR011698,InterPro:IPR017929,InterPro:IPR029062,UniProtKB/TrEMBL:I6XI14,NCBI_GP:CCP46539.1;Name=CCP46539.1;Note=Rv3713%2C (MTV025.061)%2C len: 231 aa. Possible cobQ2%2Ccobyric acid synthase%2C equivalent to O69521|ML2327|MLCB2407.23c hypothetical 24.5 KDA protein from Mycobacterium leprae (230 aa)%2C FASTA scores: opt: 1313%2C E(): 4.7e-73%2C (86.1%25 identity in 230 aa overlap). Also partially similar to several cobyric acid synthases and hypothetical proteins e.g. Q9FCA0|2SCG58.13 hypothetical 26.2 KDA protein from Streptomyces coelicolor (242 aa)%2C FASTA scores: opt: 639%2C E(): 6.2e-32%2C (46.6%25 identity in 234 aa overlap)%3B Q9ZGG8|COBQ cobyric acid synthase from Heliobacillus mobilis (252 aa)%2C FASTA scores: opt: 501%2C E(): 1.7e-23%2C (40.75%25 identity in 206 aa overlap)%3B BAB58053|SAV1891 hypothetical 27.4 KDA protein from Staphylococcus aureus subsp. aureus Mu50 (243 aa)%2CFASTA scores: opt: 400%2C E(): 2.3e-17%2C (35.95%25 identity in 217 aa overlap)%3B Q9CGJ1|COBQ cobyric acid synthase from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (261 aa)%2C FASTA scores: opt: 353%2C E(): 1.8e-14%2C (35.3%25 identity in 201 aa overlap)%3B O26880|COBQ_METTH|MTH787 probable cobyric acid synthase from Methanobacterium thermoautotrophicum (504 aa)%2C FASTA scores: opt: 201%2C E(): 5.6e-05%2C (33.35%25 identity in 171 aa overlap)%3B etc. Also similar to hypothetical mycobacterial proteins O05811|COBB_MYCTU|Rv2848c|MT2914|MTCY24A1.09 (457 aa) and P71842|Rv0789c|MTCY369.33c (199 aa). Seems to belong to the COBB/COBQ family%2C COBQ subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=cobQ2;locus_tag=Rv3713;product=Possible cobyric acid synthase CobQ2;protein_id=CCP46539.1;transl_table=11
AL123456.3	EMBL	gene	4158931	4159821	.	-	.	ID=gene-Rv3714c;Name=Rv3714c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3714c
AL123456.3	EMBL	CDS	4158931	4159821	.	-	0	ID=cds-CCP46540.1;Parent=gene-Rv3714c;Dbxref=EnsemblGenomes-Gn:Rv3714c,EnsemblGenomes-Tr:CCP46540,GOA:O69681,InterPro:IPR011335,InterPro:IPR025159,UniProtKB/TrEMBL:O69681,NCBI_GP:CCP46540.1;Name=CCP46540.1;Note=Rv3714c%2C (MTV025.062c)%2C len: 296 aa. Conserved hypothetical protein%2C highly similar to O07396|MAV346 MAV346 protein from Mycobacterium avium (346 aa) FASTA scores: opt: 834%2C E(): 2.2e-46%2C (50.0%25 identity in 286 aa overlap)%3B and also highly similar to several proteins from Mycobacterium tuberculosis e.g. O53421|Rv1073|MTV017.26 (283 aa)%2C FASTA scores: opt: 869%2C E(): 1e-48%2C (51.1%25 identity in 270 aa overlap)%3B P71763|Rv1482c|MTCY277.03c (339 aa)%2C FASTA scores: opt: 775%2C E(): 1.3e-42%2C (46.35%25 identity in 289 aa overlap)%3B P96837|Rv3555c|MTCY06G11.02c (289 aa)%2C FASTA scores: opt: 733%2C E(): 5.9e-40%2C (44.15%25 identity in 281 aa overlap)%3B etc. Partially similar to Q9Z512|UVRC_STRCO|SCC54.13c excinuclease ABC subunit C from Streptomyces coelicolor (728 aa)%2C FASTA scores: opt: 122%2CE(): 2.5%2C (27.0%25 identity in 174 aa overlap). Equivalent to AAK48186 from Mycobacterium tuberculosis strain CDC1551 (341 aa) but shorter 45 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3714c;product=Conserved hypothetical protein;protein_id=CCP46540.1;transl_table=11
AL123456.3	EMBL	gene	4159889	4160500	.	-	.	ID=gene-Rv3715c;Name=recR;gbkey=Gene;gene=recR;gene_biotype=protein_coding;locus_tag=Rv3715c
AL123456.3	EMBL	CDS	4159889	4160500	.	-	0	ID=cds-CCP46541.1;Parent=gene-Rv3715c;Dbxref=EnsemblGenomes-Gn:Rv3715c,EnsemblGenomes-Tr:CCP46541,GOA:P9WHI3,InterPro:IPR000093,InterPro:IPR003583,InterPro:IPR006171,InterPro:IPR015967,InterPro:IPR023627,InterPro:IPR023628,NCBI_GP:CCP46541.1;Name=CCP46541.1;Note=Rv3715c%2C (MTV025.063c)%2C len: 203 aa. Probable recR%2Crecombination protein (see citation below)%2C equivalent to O69520|RECR_MYCLE|ML2329|MLCB2407.21 recombination protein from Mycobacterium leprae (203 aa)%2C FASTA scores: opt: 1246%2C E(): 9.2e-71%2C (91.6%25 identity in 202 aa overlap). Also highly similar to many e.g. Q9XAI4|RECR_STRCO|SC66T3.29c from Streptomyces coelicolor (199 aa)%2C FASTA scores: opt: 952%2C E(): 1.9e-52%2C (68.3%25 identity in 202 aa overlap)%3B P24277|RECR_BACSU|RECM|recd from Bacillus subtilis (198 aa)%2C FASTA scores: opt: 696%2CE(): 1.8e-36%2C (50.5%25 identity in 198 aa overlap)%3B Q9ZNA2|RECR_DEIRA|DR0198 from Deinococcus radiodurans (220 aa)%2C FASTA scores: opt: 673%2C E(): 5.2e-35%2C (49.75%25 identity in 195 aa overlap)%3B etc. Belongs to the RECR family.;gbkey=CDS;gene=recR;locus_tag=Rv3715c;product=Probable recombination protein RecR;protein_id=CCP46541.1;transl_table=11
AL123456.3	EMBL	gene	4160512	4160913	.	-	.	ID=gene-Rv3716c;Name=Rv3716c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3716c
AL123456.3	EMBL	CDS	4160512	4160913	.	-	0	ID=cds-CCP46542.1;Parent=gene-Rv3716c;Dbxref=EnsemblGenomes-Gn:Rv3716c,EnsemblGenomes-Tr:CCP46542,GOA:P9WNR9,InterPro:IPR004401,NCBI_GP:CCP46542.1;Name=CCP46542.1;Note=Rv3716c%2C (MTV025.064c)%2C len: 133 aa. Conserved protein%2C equivalent to O69519|Y1B6_MYCLE|ML2330|MLCB2407.20 hypothetical 11.9 KDA protein from Mycobacterium leprae (116 aa)%2C FASTA scores: opt: 616%2C E(): 2.6e-21%2C (84.55%25 identity in 110 aa overlap). Also highly similar to hypothetical ~~12 kDa proteins in the vicinity of recR from other bacteria e.g. Q9XAI3|YT3D_STRCO|SC66T3.30c hypothetical 11.7 KDA protein from Streptomyces coelicolor (115 aa)%2C FASTA scores: opt: 379%2C E(): 9.5e-11%2C (50.8%25 identity in 122 aa overlap)%3B BAB56641|SAV0479 conserved hypothetical protein from Staphylococcus aureus subsp. aureus Mu50 (105 aa) FASTA scores: opt: 295%2C E(): 4.9e-07%2C(41.75%25 identity in 103 aa overlap)%3B Q99WC4P24281|YAAK_BACSU hypothetical 11.8 KDA protein in DNAZ-RECR intergenic region from Bacillus subtilis (107 aa)%2C FASTA scores: opt: 272%2C E(): 5.3e-06%2C (39.4%25 identity in 104 aa overlap)%3B P17577|YBAB_ECOLI|B0471|Z0588|ECS0524 from Escherichia coli strain K and O157:H7 (109 aa)%2C FASTA scores: opt: 256%2C E(): 2.8e-05%2C (38.0%25 identity in 100 aa overlap)%3B etc. Contains probable coiled-coil domain from aa 1-40. Seems to belong to the UPF0133 family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3716c;product=Conserved protein;protein_id=CCP46542.1;transl_table=11
AL123456.3	EMBL	gene	4161048	4161773	.	+	.	ID=gene-Rv3717;Name=Rv3717;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3717
AL123456.3	EMBL	CDS	4161048	4161773	.	+	0	ID=cds-CCP46543.1;Parent=gene-Rv3717;Dbxref=EnsemblGenomes-Gn:Rv3717,EnsemblGenomes-Tr:CCP46543,GOA:I6Y4D2,InterPro:IPR002508,UniProtKB/TrEMBL:I6Y4D2,NCBI_GP:CCP46543.1;Name=CCP46543.1;Note=Rv3717%2C (MTV025.065)%2C len: 241 aa. Conserved hypothetical protein%2C equivalent to O69518|MLCB2407.19c (alias Q9CB75|ML2331 256 aa) hypothetical 25.1 KDA protein from Mycobacterium leprae (244 aa)%2C FASTA scores: opt: 1325%2C E(): 5.7e-74%2C (81.95%25 identity in 244 aa overlap). Also similar to Q9KXK7|SCC53.04 putative secreted protein from Streptomyces coelicolor (336 aa)%2C FASTA scores: opt: 536%2C E(): 1.2e-25%2C (41.2%25 identity in 233 aa overlap)%3B and shows similarity with C-terminal end of other proteins e.g. Q9RMZ0|PXO2-42 PXO2-42 protein from Bacillus anthracis (531 aa)%2C FASTA scores: opt: 191%2C E(): 0.00022%2C (26.6%25 identity in 222 aa overlap)%3B Q9RTX0 putative N-acetylmuramoyl-L-alanine amidase (603 aa)%3B Q9LCR4|CWLU CWLU protein from Paenibacillus polymyxa (Bacillus polymyxa) (524 aa)%2C FASTA scores: opt: 141%2C E(): 0.24%2C(29.2%25 identity in 219 aa overlap)%3B etc. Shows similarity with C-terminal end of O53593|CWLM|Rv3915|MTV028.06 putative hydrolase from Mycobacterium tuberculosis (406 aa)%2C FASTA scores: opt: 176%2C E(): 0.0014%2C (25.7%25 identity in 218 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3717;product=Conserved hypothetical protein;protein_id=CCP46543.1;transl_table=11
AL123456.3	EMBL	gene	4161815	4162258	.	-	.	ID=gene-Rv3718c;Name=Rv3718c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3718c
AL123456.3	EMBL	CDS	4161815	4162258	.	-	0	ID=cds-CCP46544.1;Parent=gene-Rv3718c;Dbxref=EnsemblGenomes-Gn:Rv3718c,EnsemblGenomes-Tr:CCP46544,InterPro:IPR014488,InterPro:IPR019587,InterPro:IPR023393,UniProtKB/TrEMBL:I6XI16,NCBI_GP:CCP46544.1;Name=CCP46544.1;Note=Rv3718c%2C (MTV025.066c)%2C len: 147 aa. Conserved protein%2C equivalent to O69517|ML2332|MLCB2407.18 hypothetical 15.5 KDA protein from Mycobacterium leprae (145 aa)%2C FASTA scores: opt: 780%2C E(): 1.4e-44%2C (81.95%25 identity in 144 aa overlap). Also highly similar to Q9ZBJ2|SC9C7.18 conserved hypothetical protein from Streptomyces coelicolor (147 aa) FASTA scores: opt: 475%2CE(): 1.7e-24%2C (52.05%25 identity in 146 aa overlap)%3B and showing some similarity to various proteins e.g. P27538|PR2_PETCR pathogenesis-related protein 2 from Petroselinum crispum (Parsley) (Petroselinum hortense) (158 aa)%3B P92918|ALL2_APIGR major allergen API G 2 from Apium graveolens (Celery) (159 aa)%3B etc. Thought to be differentially expressed within host cells (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3718c;product=Conserved protein;protein_id=CCP46544.1;transl_table=11
AL123456.3	EMBL	gene	4162306	4163718	.	+	.	ID=gene-Rv3719;Name=Rv3719;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3719
AL123456.3	EMBL	CDS	4162306	4163718	.	+	0	ID=cds-CCP46545.1;Parent=gene-Rv3719;Dbxref=EnsemblGenomes-Gn:Rv3719,EnsemblGenomes-Tr:CCP46545,GOA:O69686,InterPro:IPR006094,InterPro:IPR016164,InterPro:IPR016166,InterPro:IPR016169,UniProtKB/TrEMBL:O69686,NCBI_GP:CCP46545.1;Name=CCP46545.1;Note=Rv3719%2C (MTV025.067)%2C len: 470 aa. Conserved protein%2C equivalent to O69516|ML2333|MLCB2407.17c hypothetical 51.8 KDA protein from Mycobacterium leprae (459 aa)%2C FASTA scores: opt: 2593%2C E(): 7.8e-161%2C (82.75%25 identity in 458 aa overlap). Also some similarity to Q9CU63|5830417J06RIK hypothetical protein (fragment) from Mus musculus (Mouse) (479 aa) FASTA scores: opt: 454%2C E(): 6.1e-22%2C (27.1%25 identity in 413 aa overlap)%3B Q9HBA8 seladin-1 (unknown) from Homo sapiens (Human) (516 aa)%2CFASTA scores: opt: 444%2C E(): 2.9e-21%2C (26.7%25 identity in 412 aa overlap)%3B O17397|DIMH_CAEEL|F52H2.6 diminuto-like protein from Caenorhabditis elegans (525 aa)%2C FASTA scores: opt: 419%2C E(): 1.2e-19%2C (24.4%25 identity in 434 aa overlap)%3B Q39085|DIM_ARATH|DWF1 cell elongation protein diminuto from Arabidopsis thaliana (Mouse-ear cress) (561 aa) FASTA scores: opt: 318%2C E(): 4.8e-13%2C (24.6%25 identity in 455 aa overlap)%3B etc. Also some similarity to Mycobacterium tuberculosis hypothetical proteins P72056|Rv3790|MTCY13D12.24 (461 aa) FASTA scores: opt: 174%2CE(): 0.00016%3B (25.1%25 identity in 426 aa overlap)%3B and Q50685|Rv2280|MTCY339_30c (459 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3719;product=Conserved protein;protein_id=CCP46545.1;transl_table=11
AL123456.3	EMBL	gene	4163736	4164998	.	+	.	ID=gene-Rv3720;Name=Rv3720;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3720
AL123456.3	EMBL	CDS	4163736	4164998	.	+	0	ID=cds-CCP46546.1;Parent=gene-Rv3720;Dbxref=EnsemblGenomes-Gn:Rv3720,EnsemblGenomes-Tr:CCP46546,GOA:O69687,InterPro:IPR003333,InterPro:IPR029063,UniProtKB/TrEMBL:O69687,NCBI_GP:CCP46546.1;Name=CCP46546.1;Note=Rv3720%2C (MTV025.068)%2C len: 420 aa. Possible fatty-acyl-phospholipid synthase%2C equivalent to Q9CB74|ML2334 (alias O69515|MLCB2407.16c%2C 439 aa) hypothetical protein from Mycobacterium leprae (420 aa) FASTA scores: opt: 2508%2C E(): 4.7e-153%2C (86.45%25 identity in 420 aa overlap). Also similar (especially at the C-terminus) to various fatty-acid synthases (principally cyclopropane-fatty-acyl-phospholipid synthases) and hypothetical proteins e.g. Q9KZ58|SCE25.32c putative fatty acid synthase from Streptomyces coelicolor (438 aa)%2C FASTA scores: opt: 1101%2C E(): 5.5e-63%2C (46.1%25 identity in 425 aa overlap)%3B P31049|YLP3_PSEPU hypothetical 44.7 KDA protein from Pseudomonas putida (394 aa)%2C FASTA scores: opt: 810%2CE(): 2.1e-44%2C (46.4%25 identity in 293 aa overlap)%3B Q9HT28|PA5546 hypothetical protein from Pseudomonas aeruginosa (394 aa)%2C FASTA scores: opt: 804%2C E(): 5.2e-44%2C(40.7%25 identity in 371 aa overlap)%3B Q9RSD7|DR2187 putative cyclopropane-fatty-acyl-phospholipid synthase from Deinococcus radiodurans (462 aa)%2C FASTA scores: opt: 747%2CE(): 2.6e-40%2C (35.95%25 identity in 409 aa overlap)%3B BAB50831|Q98ET6|MLL4091 cyclopropane-fatty-acyl-phospholipid synthase from Rhizobium loti (Mesorhizobium loti) (422 aa)%2C FASTA scores: opt: 674%2C E(): 1.1e-35%2C (39.1%25 identity in 284 aa overlap)%3B P30010|CFA_ECOLI|CDFA|B1661 cyclopropane-fatty-acyl-phospholip synthase from Escherichia coli strain K12 (381 aa)%2C FASTA scores: opt: 530%2C E(): 1.7e-26%2C (33.65%25 identity in 312 aa overlap)%3B etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa)%3B P96911|Rv0621|MTCY20H10 (354 aa)%3B O50416|LPQD|Rv3390|MTV004.48 (236 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3720;product=Possible fatty acid synthase;protein_id=CCP46546.1;transl_table=11
AL123456.3	EMBL	gene	4164995	4166731	.	-	.	ID=gene-Rv3721c;Name=dnaZX;gbkey=Gene;gene=dnaZX;gene_biotype=protein_coding;locus_tag=Rv3721c
AL123456.3	EMBL	CDS	4164995	4166731	.	-	0	ID=cds-CCP46547.1;Parent=gene-Rv3721c;Dbxref=EnsemblGenomes-Gn:Rv3721c,EnsemblGenomes-Tr:CCP46547,GOA:P9WNT9,InterPro:IPR003593,InterPro:IPR008921,InterPro:IPR012763,InterPro:IPR022754,InterPro:IPR027417,NCBI_GP:CCP46547.1;Name=CCP46547.1;Note=Rv3721c%2C (MTV025.069c)%2C len: 578 aa. Probable dnaZX%2CDNA polymerase III gamma (dnaZ) and tau (dnaX)%2C equivalent to O69514|DNAZX|ML2335 DNA polymerase III subunit gamma/tau from Mycobacterium leprae (611 aa) FASTA scores: opt: 2344%2CE(): 4.7e-118%2C (78.75%25 identity in 602 aa overlap). Also highly similar to many e.g. Q9RKL5|DNAZ from Streptomyces coelicolor (784 aa) FASTA scores: opt: 1755%2C E(): 1.8e-86%2C(59.55%25 identity in 435 aa overlap)%3B Q9KGM4|DNAX|BH0034 from Bacillus halodurans (564 aa)%2C FASTA scores: opt: 946%2CE(): 2.5e-43%2C (37.4%25 identity in 460 aa overlap)%3B P09122|DP3X_BACSU|DNAX|DNAH from Bacillus subtilis (563 aa)%2C FASTA scores: opt: 841%2C E(): 1e-37%2C (30.8%25 identity in 510 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;gbkey=CDS;gene=dnaZX;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3721c;product=DNA polymerase III (subunit gamma/tau) DnaZ/X;protein_id=CCP46547.1;transl_table=11
AL123456.3	EMBL	gene	4166821	4168128	.	-	.	ID=gene-Rv3722c;Name=Rv3722c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3722c
AL123456.3	EMBL	CDS	4166821	4168128	.	-	0	ID=cds-CCP46548.1;Parent=gene-Rv3722c;Dbxref=EnsemblGenomes-Gn:Rv3722c,EnsemblGenomes-Tr:CCP46548,GOA:O69689,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR024551,UniProtKB/TrEMBL:O69689,NCBI_GP:CCP46548.1;Name=CCP46548.1;Note=Rv3722c%2C (MTV025.070c)%2C len: 435 aa. Conserved protein%2C equivalent to O69513|MLCB2407.14 (alias Q9CB73|ML2336%2C 463 aa) hypothetical 46.8 KDA protein from Mycobacterium leprae (426 aa)%2C FASTA scores: opt: 2505%2CE(): 8.3e-154%2C (87.25%25 identity in 424 aa overlap). Also highly similar to Q9RU17|DR1579 conserved hypothetical protein from Deinococcus radiodurans (452 aa)%2C FASTA scores: opt: 1162%2C E(): 3.1e-67%2C (44.8%25 identity in 422 aa overlap)%3B and partially similar to Q9I371|PA1654 probable aminotransferase from Pseudomonas aeruginosa (388 aa) FASTA scores: opt: 162%2C E(): 0.0078%2C (25.85%25 identity in 348 aa overlap) and other aminotransferases. N-terminus extended since first submission (previously 408 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3722c;product=Conserved protein;protein_id=CCP46548.1;transl_table=11
AL123456.3	EMBL	gene	4168154	4168281	.	-	.	ID=gene-C8;Name=C8;gbkey=Gene;gene=C8;gene_biotype=ncRNA;gene_synonym=mcr6
AL123456.3	EMBL	ncRNA	4168154	4168281	.	-	.	ID=rna-C8;Parent=gene-C8;Note=C8%2C possible 4.5S RNA (See Arnvig and Young%2C 2009%3B DiChiara et al.%2C 2010)%2C part of signal recognition particle with protein Ffh. Alternate 3'-ends at positions 4168212 and 4168224.;gbkey=ncRNA;gene=C8;product=Possible 4.5S RNA in signal recognition particle (small cytoplasmic RNA) (SC-RNA)
AL123456.3	EMBL	exon	4168154	4168281	.	-	.	ID=exon-C8-1;Parent=rna-C8;Note=C8%2C possible 4.5S RNA (See Arnvig and Young%2C 2009%3B DiChiara et al.%2C 2010)%2C part of signal recognition particle with protein Ffh. Alternate 3'-ends at positions 4168212 and 4168224.;gbkey=ncRNA;gene=C8;product=Possible 4.5S RNA in signal recognition particle (small cytoplasmic RNA) (SC-RNA)
AL123456.3	EMBL	gene	4168345	4168430	.	+	.	ID=gene-serV;Name=serV;gbkey=Gene;gene=serV;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	4168345	4168430	.	+	.	ID=rna-serV;Parent=gene-serV;Note=codon recognized: UCC%3B serV%2C tRNA-Ser%2C anticodon gga%2C length %3D 86;anticodon=(pos:4168379..4168381);gbkey=tRNA;gene=serV;product=tRNA-Ser
AL123456.3	EMBL	exon	4168345	4168430	.	+	.	ID=exon-serV-1;Parent=rna-serV;Note=codon recognized: UCC%3B serV%2C tRNA-Ser%2C anticodon gga%2C length %3D 86;anticodon=(pos:4168379..4168381);gbkey=tRNA;gene=serV;product=tRNA-Ser
AL123456.3	EMBL	gene	4168536	4169300	.	+	.	ID=gene-Rv3723;Name=Rv3723;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3723
AL123456.3	EMBL	CDS	4168536	4169300	.	+	0	ID=cds-CCP46549.1;Parent=gene-Rv3723;Dbxref=EnsemblGenomes-Gn:Rv3723,EnsemblGenomes-Tr:CCP46549,GOA:O69690,UniProtKB/TrEMBL:O69690,NCBI_GP:CCP46549.1;Name=CCP46549.1;Note=Rv3723%2C (MTV025.071)%2C len: 254 aa. Probable conserved transmembrane protein%2C with hydrophobic stretches at the N-terminus%2C and equivalent to O69512|ML2337|MLCB2407.13c putative membrane protein from Mycobacterium leprae (250 aa)%2C FASTA scores: opt: 1029%2CE(): 1.2e-44%2C (64.45%25 identity in 253 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3723;product=Probable conserved transmembrane protein;protein_id=CCP46549.1;transl_table=11
AL123456.3	EMBL	gene	4169467	4169709	.	+	.	ID=gene-Rv3724A;Name=cut5a;gbkey=Gene;gene=cut5a;gene_biotype=protein_coding;locus_tag=Rv3724A
AL123456.3	EMBL	CDS	4169467	4169709	.	+	0	ID=cds-CCP46550.1;Parent=gene-Rv3724A;Dbxref=EnsemblGenomes-Gn:Rv3724A,EnsemblGenomes-Tr:CCP46550,GOA:Q79FA5,InterPro:IPR000675,InterPro:IPR029058,UniProtKB/TrEMBL:Q79FA5,NCBI_GP:CCP46550.1;Name=CCP46550.1;Note=Rv3724A%2C (MTV025.072)%2C len: 80 aa. Probable cut5a%2Ctruncated cutinase precursor%2C similar to N-terminal end of others e.g. Q9KK87 serine esterase cutinase from Mycobacterium avium (220 aa)%2C FASTA scores: opt: 202%2C E(): 1.5e-06%2C (56.45%25 identity in 62 aa overlap)%3B Q9XB09|RVD2-RV1758 protein (fragment) from Mycobacterium bovis BCG (143 aa)%2C FASTA scores: opt: 200%2C E(): 1.5e-06%2C(61.4%25 identity in 57 aa overlap)%3B and Q00298|CUTI_BOTCI|CUTA cutinase precursor from Botrytis cinerea (Botryotinia fuckeliana) (202 aa)%2C FASTA scores: opt: 108%2C E(): 2.2%2C (40.4%25 identity in 52 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 probable cutinase precursor (247 aa)%2C FASTA scores: opt: 189%2C E(): 1.2e-05%2C (58.0%25 identity in 50 aa overlap)%3B Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c probable cutinase precursor (219 aa)%2C FASTA scores: opt: 172%2C E(): 0.00015%2C (59.2%25 identity in 49 aa overlap)%3B O06793|Rv1758|MTCY28.24|Z95890 hypothetical 17.9 KDA protein (174 aa)%2C FASTA scores: opt: 641%2C E(): 2.7e-29%2C(57.2%25 identity in 166 aa overlap)%3B O06319|Rv3452|MTY13E12.05%3B and U00015_11 from Mycobacterium leprae. Belongs to the cutinase family. Rest of cutinase ORF continues as Rv3724B|CUT5B%2C frameshifting could occur near position 4169668. Sequence has been checked but no errors found.;gbkey=CDS;gene=cut5a;locus_tag=Rv3724A;product=Probable cutinase precursor [first part] Cut5a;protein_id=CCP46550.1;transl_table=11
AL123456.3	EMBL	gene	4169606	4170169	.	+	.	ID=gene-Rv3724B;Name=cut5b;gbkey=Gene;gene=cut5b;gene_biotype=protein_coding;gene_synonym=clp7,culp7;locus_tag=Rv3724B
AL123456.3	EMBL	CDS	4169606	4170169	.	+	0	ID=cds-CCP46551.1;Parent=gene-Rv3724B;Dbxref=EnsemblGenomes-Gn:Rv3724B,EnsemblGenomes-Tr:CCP46551,GOA:Q79FA4,InterPro:IPR000675,InterPro:IPR029058,UniProtKB/TrEMBL:Q79FA4,NCBI_GP:CCP46551.1;Name=CCP46551.1;Note=Rv3724B%2C (MTV025.072)%2C len: 187 aa. Probable cut5b%2Ctruncated cutinase%2C similar to C-terminal end of others e.g. Q9XB09|RVD2-RV1758 protein (fragment) from Mycobacterium bovis BCG (143 aa) FASTA scores: opt: 335%2CE(): 3.4e-12%2C (53.25%25 identity in 92 aa overlap)%3B Q9KK87 serine esterase cutinase from Mycobacterium avium (220 aa)%2CFASTA scores: opt: 251%2C E(): 2.5e-07%2C (44.05%25 identity in 168 aa overlap). Also similar to proteins from Mycobacterium tuberculosis e.g. O06793|Rv1758|MTCY28.24 hypothetical 17.9 KDA protein (174 aa)%2C FASTA scores: opt: 641%2C E(): 2.5e-29%2C (57.25%25 identity in 166 aa overlap)%3B O06319|Rv3452|MTCY13E12.05 hypothetical 23.1 KDA protein (226 aa)%2C FASTA scores: opt: 385%2C E(): 7.5e-15%2C (46.65%25 identity in 165 aa overlap)%3B O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 probable cutinase precursor (247 aa)%2C FASTA scores: opt: 307%2C E(): 1.9e-10%2C (40.7%25 identity in 167 aa overlap)%3B Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 probable cutinase precursor (217 aa)%2C FASTA scores: opt: 261%2C E(): 6.7e-08%2C (50.9%25 identity in 169 aa overlap)%3B etc%3B and U00015_11 from Mycobacterium lepra. 5'-end of gene is Rv3724A|CUT5A%3B frameshifting may occur near position 4169668.;gbkey=CDS;gene=cut5b;locus_tag=Rv3724B;product=Probable cutinase [second part] Cut5b;protein_id=CCP46551.1;transl_table=11
AL123456.3	EMBL	gene	4170214	4171143	.	+	.	ID=gene-Rv3725;Name=Rv3725;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3725
AL123456.3	EMBL	CDS	4170214	4171143	.	+	0	ID=cds-CCP46552.1;Parent=gene-Rv3725;Dbxref=EnsemblGenomes-Gn:Rv3725,EnsemblGenomes-Tr:CCP46552,GOA:O69692,InterPro:IPR001509,InterPro:IPR016040,UniProtKB/TrEMBL:O69692,NCBI_GP:CCP46552.1;Name=CCP46552.1;Note=Rv3725%2C (MTV025.073)%2C len: 309 aa. Possible reductase%2C similar to various oxidoreductases and hypothetical proteins e.g. O34285|HPNA HPNA protein from Zymomonas mobilis (337 aa)%2C FASTA scores: opt: 317%2C E(): 6.1e-11%2C (30.5%25 identity in 272 aa overlap)%3B Q9SZB3|F17M5.120|AT4G33360|AAK49584 hypothetical 37.9 KDA protein from Arabidopsis thaliana (Mouse-ear cress) (344 aa)%2C FASTA scores: opt: 314%2C E(): 9.1e-11%2C (30.35%25 identity in 267 aa overlap)%3B AAK59445|AT4G33360 putative dihydrokaempferol 4-reductase from Arabidopsis thaliana (Mouse-ear cress) (332 aa)%2C FASTA scores: opt: 313%2C E(): 1e-10%2C (30.8%25 identity in 263 aa overlap)%3B Q9FSC6|CCR cinnamoyl-CoA reductase from Populus trichocarpa (Western balsam poplar) (338 aa)%2C FASTA scores: opt: 305%2C E(): 2.9e-10%2C (30.3%25 identity in 274 aa overlap)%3B Q9M631 cinnamoyl CoA reductase from Populus tremuloides (Quaking aspen) (337 aa)%2C FASTA scores: opt: 291%2C E(): 1.8e-09%2C(30.15%25 identity in 272 aa overlap)%3B P73212|DFRA_SYNY3|LR1706 putative dihydroflavonol-4-reductase (dihydrokaempferol 4-reductase) from Synechocystis sp. strain PCC 6803 (343 aa)%2C FASTA scores: opt: 278%2C E(): 1e-08%2C (29.35%25 identity in 259 aa overlap)%3B etc. Also some similarity to proteins from Mycobacterium tuberculosis e.g. P96816|Rv0139|MTCI5.13 hypothetical protein (340 aa) FASTA scores: opt: 234%2C E(): 3.2e-06%2C (28.25%25 identity in 269 aa overlap)%3B and O06373|galE1|Rv3634c|MTCY15C10.18 probable UDP-glucose 4-epimerase (314 aa) (27.3%25 identity in 194 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3725;product=Possible oxidoreductase;protein_id=CCP46552.1;transl_table=11
AL123456.3	EMBL	gene	4171421	4172614	.	+	.	ID=gene-Rv3726;Name=Rv3726;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3726
AL123456.3	EMBL	CDS	4171421	4172614	.	+	0	ID=cds-CCP46553.1;Parent=gene-Rv3726;Dbxref=EnsemblGenomes-Gn:Rv3726,EnsemblGenomes-Tr:CCP46553,GOA:O69693,InterPro:IPR002085,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR016040,UniProtKB/TrEMBL:O69693,NCBI_GP:CCP46553.1;Name=CCP46553.1;Note=Rv3726%2C (MTV025.074)%2C len: 397 aa. Possible dehydrogenase%2C similar to many e.g. O34788|YDJL dehydrogenase from Bacillus subtilis (346 aa) FASTA scores: opt: 401%2C E(): 3.4e-17%2C (29.6%25 identity in 395 aa overlap)%3B Q59696|ADH 2%2C3-butanediol dehydrogenase from seudomonas putida (362 aa)%2C FASTA scores: opt: 326%2C E(): 1.3e-12%2C(29.45%25 identity in 387 aa overlap)%3B AAG59541|YJJN putative oxidoreductase from Escherichia coli strain EDL933 (345 aa)%2C FASTA scores: opt: 325%2C E(): 1.5e-12%2C (30.85%25 identity in 256 aa overlap)%3B Q9HWM8|PA4153 2%2C3-butanediol dehydrogenase from Pseudomonas aeruginosa (363 aa)%2C FASTA scores: opt: 324%2C E(): 1.8e-12%2C (30.5%25 identity in 387 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3726;product=Possible dehydrogenase;protein_id=CCP46553.1;transl_table=11
AL123456.3	EMBL	gene	4172955	4174763	.	+	.	ID=gene-Rv3727;Name=Rv3727;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3727
AL123456.3	EMBL	CDS	4172955	4174763	.	+	0	ID=cds-CCP46554.1;Parent=gene-Rv3727;Dbxref=EnsemblGenomes-Gn:Rv3727,EnsemblGenomes-Tr:CCP46554,GOA:O69694,UniProtKB/TrEMBL:O69694,NCBI_GP:CCP46554.1;Name=CCP46554.1;Note=Rv3727%2C (MTV025.075)%2C len: 602 aa. Possible oxidoreductase%2C similar to several plants phytoene dehydrogenases/desaturases e.g. Q9HSE1|CRTI3|VNG0277G phytoene dehydrogenase from Halobacterium sp. strain NRC-1 (541 aa)%2C FASTA scores: opt: 299%2C E(): 1.1e-10%2C (29.85%25 identity in 576 aa overlap)%3B Q9FZL6|CITPDS1 phytoene desaturase from Citrus unshiu (Satsuma orange) (553 aa)%2CFASTA scores: opt: 164%2C E(): 0.018%2C (24.2%25 identity in 434 aa overlap)%3B Q07356|CRTI_ARATH|PDS|AT4G14210|DL3145c phytoene dehydrogenase precursor from Arabidopsis thaliana (Mouse-ear cress) (566 aa)%2C FASTA scores: opt: 163%2C E(): 0.021%2C (23.95%25 identity in 434 aa overlap)%3B etc. N-terminal end similar to O69871|SC1C3.29 putative protoporphyrinogen oxidase (fragment) from Streptomyces coelicolor (61 aa)%2CFASTA scores: opt: 154%2C E(): 0.012%2C (60.45%25 identity in 43 aa overlap). The region between aa 155-310 is highly similar to Q49778|B2126_C1_169 from Mycobacterium leprae (159 aa)%2C FASTA scores: opt: 437%2C E(): 1.5e-19%2C (46.6%25 identity in 161 aa overlap). And the region between aa 462-546 is highly similar to the N-terminal end of Q50003|U1764T from Mycobacterium leprae (155 aa)%2C FASTA scores: opt: 277%2C E(): 8.3e-10%2C (57.65%25 identity in 85 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3727;product=Possible oxidoreductase;protein_id=CCP46554.1;transl_table=11
AL123456.3	EMBL	gene	4174873	4178070	.	+	.	ID=gene-Rv3728;Name=Rv3728;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3728
AL123456.3	EMBL	CDS	4174873	4178070	.	+	0	ID=cds-CCP46555.1;Parent=gene-Rv3728;Dbxref=EnsemblGenomes-Gn:Rv3728,EnsemblGenomes-Tr:CCP46555,GOA:O69695,InterPro:IPR000595,InterPro:IPR001411,InterPro:IPR002641,InterPro:IPR004638,InterPro:IPR005829,InterPro:IPR011701,InterPro:IPR014710,InterPro:IPR016035,InterPro:IPR016196,InterPro:IPR018488,InterPro:IPR018490,InterPro:IPR020846,UniProtKB/TrEMBL:O69695,NCBI_GP:CCP46555.1;Name=CCP46555.1;Note=Rv3728%2C (MTV025.076)%2C len: 1065 aa. Probable conserved transmembrane protein organised into two domains. Domain comprising the first ~~510 aa residues is similar to various multidrug resistance and efflux proteins and contains sugar transport protein signature 1 (PS00216). Domain corresponding to the last 550 aa residues contains cyclic nucleotide-binding domain signature 2 (PS00889) and is very similar to Q50733|YP65_MYCTU|Rv2565|MT2641|MTCY9C4.03c hypothetical 62.1 kDa protein from Mycobacterium tuberculosis (31.0%25 identity in 546 aa overlap). Highly similar to O05884|Rv3239c|MTCY20B11.14c probable transmembrane transport protein from Mycobacterium tuberculosis (1048 aa) FASTA scores: opt: 4328%2C E(): 5e-201%2C (64.15%25 identity in 1046 aa overlap). N-terminal end similar to P71879|Rv2333c|MTCY3G12.01|MTCY98.02c (537 aa)%3B P71836|Rv0783c|MTCY369.27c (540 aa)%3B and O07753|Rv1877|MTCY180.41c (687 aa). Seems belong to the sugar transporter family. Possibly member of major facilitator superfamily (MFS).;gbkey=CDS;inference=protein motif:PROSITE:PS00889;locus_tag=Rv3728;product=Probable conserved two-domain membrane protein;protein_id=CCP46555.1;transl_table=11
AL123456.3	EMBL	gene	4178285	4180615	.	+	.	ID=gene-Rv3729;Name=Rv3729;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3729
AL123456.3	EMBL	CDS	4178285	4180615	.	+	0	ID=cds-CCP46556.1;Parent=gene-Rv3729;Dbxref=EnsemblGenomes-Gn:Rv3729,EnsemblGenomes-Tr:CCP46556,GOA:O69696,InterPro:IPR007197,InterPro:IPR013216,InterPro:IPR013785,InterPro:IPR029063,UniProtKB/TrEMBL:O69696,NCBI_GP:CCP46556.1;Name=CCP46556.1;Note=Rv3729%2C (MTV025.077)%2C len: 776 aa. Conserved hypothetical protein%2C possible transferase%2C similar to several hypothetical proteins and various transferases e.g. O26919|MTH831 molybdenum cofactor biosynthesis MOAA homolog from Methanobacterium thermoautotrophicum (497 aa)%2C FASTA scores: opt: 697%2C E(): 4.8e-34%2C (30.7%25 identity in 492 aa overlap)%3B Q58036|Y619_METJA|MJ0619 hypothetical protein from Methanococcus jannaschii (506 aa)%2C FASTA scores: opt: 670%2C E(): 2e-32%2C (30.6%25 identity in 497 aa overlap)%3B O27968|AF2316 conserved hypothetical protein from Archaeoglobus fulgidus (518 aa)%2C FASTA scores: opt: 477%2CE(): 6.4e-21%2C (29.4%25 identity in 500 aa overlap)%3B BAB60102|TVG0985801 molybdenum cofactor biosynthesis protein from Thermoplasma volcanium (606 aa)%2C FASTA scores: opt: 402%2C E(): 2.1e-16%2C (28.1%25 identity in 509 aa overlap)%3B etc. C-terminus similar to methyltransferases e.g. Q9S0N6|AVED C5-O-methyltransferase from Streptomyces avermitilis (283 aa)%2C FASTA scores: opt: 298%2C E(): 1.9e-10%2C(31.5%25 identity in 292 aa overlap). Also similar to the Mycobacterium tuberculosis proteins P71673|YE05_MYCTU|Rv1405c|MT1449|MTCY21B4.22c (274 aa)%3B and Q50584|Rv1523|MTCY19G5.05c.;gbkey=CDS;locus_tag=Rv3729;product=Possible transferase;protein_id=CCP46556.1;transl_table=11
AL123456.3	EMBL	gene	4180680	4181720	.	-	.	ID=gene-Rv3730c;Name=Rv3730c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3730c
AL123456.3	EMBL	CDS	4180680	4181720	.	-	0	ID=cds-CCP46557.1;Parent=gene-Rv3730c;Dbxref=EnsemblGenomes-Gn:Rv3730c,EnsemblGenomes-Tr:CCP46557,GOA:O69697,InterPro:IPR002755,InterPro:IPR014145,UniProtKB/TrEMBL:O69697,NCBI_GP:CCP46557.1;Name=CCP46557.1;Note=Rv3730c%2C (MTV025.078c)%2C len: 346 aa. Conserved hypothetical protein%2C highly similar to Q9XAM1|SC4C6.19 hypothetical 38.5 KDA protein from Streptomyces coelicolor (341 aa)%2C FASTA scores: opt: 1313%2C E(): 2.2e-75%2C (59.25%25 identity in 336 aa overlap)%3B and similar to C-terminal end of putative ATP-dependent DNA ligases e.g. BAB49297|MLL2077 from Rhizobium loti (Mesorhizobium loti) (833 aa)%2C FASTA scores: opt: 550%2C E(): 5.3e-27%2C (31.3%25 identity in 294 aa overlap)%3B and BAB54816|MLL9625 from Rhizobium loti (Mesorhizobium loti) plasmid pMLb (883 aa) FASTA scores: opt: 492%2C E(): 2.5e-23%2C (33.7%25 identity in 291 aa overlap)%3B etc. Also similar to the hypothetical proteins e.g. Q9ZC15|SC1E6.07 hypothetical 34.9 KDA protein from Streptomyces coelicolor (319 aa) FASTA scores: opt: 537%2CE(): 1.5e-26%2C (34.95%25 identity in 292 aa overlap)%3B Q9XAF7|SC6G9.25 hypothetical 32.1 KDA protein from Streptomyces coelicolor (293 aa)%2C FASTA scores: opt: 474%2CE(): 1.3e-22%2C (33.75%25 identity in 302 aa overlap)%3B etc. Also highly similar to P95226|Rv0269c|MTCY06A4.13c hypothetical 44.0 KDA protein from Mycobacterium tuberculosis (397 aa)%2C FASTA scores: opt: 940%2C E(): 7.7e-52%2C (50.3%25 identity in 312 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3730c;product=Conserved hypothetical protein;protein_id=CCP46557.1;transl_table=11
AL123456.3	EMBL	gene	4181758	4182834	.	+	.	ID=gene-Rv3731;Name=ligC;gbkey=Gene;gene=ligC;gene_biotype=protein_coding;locus_tag=Rv3731
AL123456.3	EMBL	CDS	4181758	4182834	.	+	0	ID=cds-CCP46558.1;Parent=gene-Rv3731;Dbxref=EnsemblGenomes-Gn:Rv3731,EnsemblGenomes-Tr:CCP46558,GOA:L0TDE1,InterPro:IPR012309,InterPro:IPR012310,InterPro:IPR012340,NCBI_GP:CCP46558.1;Name=CCP46558.1;Note=Rv3731%2C (MTV025.079)%2C len: 358 aa. Possible ligC%2CDNA ligase ATP-dependent (see citation below)%2C similar to numerous archaebacterial and eukaryotic polynucleotide DNA ligases e.g. Q9XAM3|SC4C6.17c from Streptomyces coelicolor (355 aa)%2C FASTA scores: opt: 1429%2C E(): 1.7e-82%2C (60.4%25 identity in 361 aa overlap)%3B BAB54870|MLL9685 from Rhizobium loti (Mesorhizobium loti) plasmid pMLb (337 aa)%2CFASTA scores: opt: 667%2C E(): 1.2e-34%2C (40.35%25 identity in 347 aa overlap)%3B Q9HH07|DNLI_THEFM|LIG from Thermococcus fumicolans (559 aa)%2C FASTA scores: opt: 335%2C E(): 1.4e-13%2C(27.25%25 identity in 330 aa overlap)%3B O59288|DNLI_PYRHO from Pyrococcus horikoshii (559 aa)%2C FASTA scores: opt: 307%2CE(): 8e-12%2C (26.85%25 identity in 272 aa overlap)%3B etc. Also similar to Rv3062|MTCY22D7_19c|LIGB probable DNA ligase from Mycobacterium tuberculosis (507 aa)%2C FASTA score: (30.3%25 identity in 356 aa overlap). Seems to belong to the ATP-dependent DNA ligase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ligC;locus_tag=Rv3731;product=Possible ATP-dependent DNA ligase LigC (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase);protein_id=CCP46558.1;transl_table=11
AL123456.3	EMBL	gene	4182934	4183992	.	+	.	ID=gene-Rv3732;Name=Rv3732;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3732
AL123456.3	EMBL	CDS	4182934	4183992	.	+	0	ID=cds-CCP46559.1;Parent=gene-Rv3732;Dbxref=EnsemblGenomes-Gn:Rv3732,EnsemblGenomes-Tr:CCP46559,GOA:O69699,InterPro:IPR019283,UniProtKB/TrEMBL:O69699,NCBI_GP:CCP46559.1;Name=CCP46559.1;Note=Rv3732%2C (MTV025.080)%2C len: 352 aa. Conserved protein. The region between aa 175-352 is highly similar to the region between aa 72-257 of Q9KH39 hypothetical 55.5 KDA protein from Mycobacterium smegmatis (511 aa)%2C FASTA scores: opt: 1122%2C E(): 7.3e-63%2C (98.85%25 identity in 176 aa overlap). Also shows some similarity with Q55304 hypotheticalk protein from Synechocystis sp. strain PCC 6803 (387 aa)%2C FASTA scores: opt: 201%2C E(): 2.7e-05%2C (27.1%25 identity in 251 aa overlap)%3B and P74254|SLR1173 hypothetical 52.5 KDA protein from Synechocystis sp. strain PCC 6803 (463 aa)%2C FASTA scores: opt: 201%2C E(): 3.1e-05%2C(27.1%25 identity in 251 aa overlap). Also slightly similar to MTCY01B2_21 and DPO1_MYCTU DNA polymerase I.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3732;product=Conserved protein;protein_id=CCP46559.1;transl_table=11
AL123456.3	EMBL	gene	4184012	4184512	.	-	.	ID=gene-Rv3733c;Name=Rv3733c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3733c
AL123456.3	EMBL	CDS	4184012	4184512	.	-	0	ID=cds-CCP46560.1;Parent=gene-Rv3733c;Dbxref=EnsemblGenomes-Gn:Rv3733c,EnsemblGenomes-Tr:CCP46560,GOA:O69700,InterPro:IPR000086,InterPro:IPR015797,InterPro:IPR020084,UniProtKB/TrEMBL:O69700,NCBI_GP:CCP46560.1;Name=CCP46560.1;Note=Rv3733c%2C (MTV025.081c)%2C len: 166 aa. Conserved hypothetical protein%2C highly similar to Q9FCB0|2SCG58.03 putative mutt-like protein from Streptomyces coelicolor (153 aa)%2C FASTA scores: opt: 541%2C E(): 7.2e-29%2C (52.7%25 identity in 148 aa overlap)%3B and BAB49143|MLR1881 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (156 aa)%2C FASTA scores: opt: 526%2C E(): 7.2e-28%2C(52.65%25 identity in 150 aa overlap).;gbkey=CDS;locus_tag=Rv3733c;product=Conserved hypothetical protein;protein_id=CCP46560.1;transl_table=11
AL123456.3	EMBL	gene	4184526	4185890	.	-	.	ID=gene-Rv3734c;Name=tgs2;gbkey=Gene;gene=tgs2;gene_biotype=protein_coding;locus_tag=Rv3734c
AL123456.3	EMBL	CDS	4184526	4185890	.	-	0	ID=cds-CCP46561.1;Parent=gene-Rv3734c;Dbxref=EnsemblGenomes-Gn:Rv3734c,EnsemblGenomes-Tr:CCP46561,GOA:P9WKC7,InterPro:IPR004255,InterPro:IPR014292,NCBI_GP:CCP46561.1;Name=CCP46561.1;Note=Rv3734c%2C (MTV025.082c)%2C len: 454 aa. Putative tgs2%2Ctriacylglycerol synthase (See Daniel et al.%2C 2004)%2C highly similar to O69707|Y1E0_MYCTU|Rv3740c|MT3848|MTV025.088c hypothetical protein from Mycobacterium tuberculosis (448 aa)%2C FASTA scores: opt: 1917%2C E(): 1.3e-111%2C (61.4%25 identity in 451 aa overlap)%3B and similar to many other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P71694|YE43_MYCTU|Rv1425|MT1468|MTCY21B4.43|MTCY493.29c (459 aa)%2C FASTA scores: opt: 824%2C E(): 1.1e-43%2C (36.5%25 identity in 460 aa overlap)%3B Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 766%2C E(): 4.1e-40%2C (36.4%25 identity in 453 aa overlap)%3B etc. Also similar to Q9RIU8|SCM11.13c hypothetical 47.1 KDA protein from Streptomyces coelicolor (446 aa)%2C FASTA scores: opt: 331%2C E(): 4.3e-13%2C (32.9%25 identity in 468 aa overlap)%3B and Q9X7A8|ML1244|MLCB1610.05 conserved membrane protein from Mycobacterium leprae (491 aa)%2C FASTA scores: opt: 296%2C E(): 7e-11%2C (28.35%25 identity in 413 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Start site chosen by homology%2C but may extend further upstream to 93257.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tgs2;inference=protein motif:PROSITE:PS00339;locus_tag=Rv3734c;product=Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2;protein_id=CCP46561.1;transl_table=11
AL123456.3	EMBL	gene	4186089	4186577	.	+	.	ID=gene-Rv3735;Name=Rv3735;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3735
AL123456.3	EMBL	CDS	4186089	4186577	.	+	0	ID=cds-CCP46562.1;Parent=gene-Rv3735;Dbxref=EnsemblGenomes-Gn:Rv3735,EnsemblGenomes-Tr:CCP46562,InterPro:IPR007153,UniProtKB/TrEMBL:O69702,NCBI_GP:CCP46562.1;Name=CCP46562.1;Note=Rv3735%2C (MTV025.083)%2C len: 162 aa. Conserved hypothetical protein%2C highly similar to several bacterial hypothetical proteins e.g. Q9UX41|ORF-C09_016|SSO0651|AAK40956 from Sulfolobus solfataricus (163 aa)%2C FASTA scores: opt: 627%2C E(): 1.2e-34%2C (55.9%25 identity in 161 aa overlap)%3B O26795|MTH699 from Methanobacterium thermoautotrophicum (168 aa)%2C FASTA scores: opt: 616%2C E(): 6.7e-34%2C (56.1%25 identity in 155 aa overlap)%3B |Q9Y9J9|APE2289 from Aeropyrum pernix (191 aa)%2CFASTA scores: opt: 591%2C E(): 3.4e-32%2C (54.65%25 identity in 161 aa overlap) %3B etc. Contains PS00435 Peroxidases proximal heme-ligand signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00435;locus_tag=Rv3735;product=Conserved hypothetical protein;protein_id=CCP46562.1;transl_table=11
AL123456.3	EMBL	gene	4186634	4187695	.	+	.	ID=gene-Rv3736;Name=Rv3736;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3736
AL123456.3	EMBL	CDS	4186634	4187695	.	+	0	ID=cds-CCP46563.1;Parent=gene-Rv3736;Dbxref=EnsemblGenomes-Gn:Rv3736,EnsemblGenomes-Tr:CCP46563,GOA:O69703,InterPro:IPR009057,InterPro:IPR018060,UniProtKB/TrEMBL:O69703,NCBI_GP:CCP46563.1;Name=CCP46563.1;Note=Rv3736%2C (MTV025.084)%2C len: 353 aa. Probable transcriptional regulator%2C araC/xylS family%2C similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 hypothetical 35.4 KDA protein from Bradyrhizobium japonicum (318 aa)%2C FASTA scores: opt: 438%2CE(): 2e-20%2C (29.4%25 identity in 306 aa overlap)%3B Q9HZ25|PA3215 probable transcriptional regulator from Pseudomonas aeruginosa (337 aa)%2C FASTA scores: opt: 395%2CE(): 1.1e-17%2C (30.3%25 identity in 320 aa overlap)%3B Q9HTN1|PA5324 probable transcriptional regulator from Pseudomonas aeruginosa (356 aa)%2C FASTA scores: opt: 313%2CE(): 1.8e-12%2C (25.85%25 identity in 329 aa overlap)%3B Q9Z3Y6|PHBR transcriptional regulator PHBR from Pseudomonas sp. 61-3 (379 aa)%2C FASTA scores: opt: 271%2C E(): 8.3e-10%2C(22.95%25 identity in 357 aa overlap)%3B etc. Also highly similar to Q06861|VIRS_MYCTU|Rv3082c|MTV013.03c possible virulence-regulating protein from Mycobacterium tuberculosis (340 aa)%2C FASTA scores: opt: 656%2C E(): 3.7e-34%2C (36.95%25 identity in 333 aa overlap)%3B and similar to other hypothetical mycobacterial proteins e.g. P71663|YD95_MYCTU|Rv1395|MT1440|MTCY21B4.12 (344 aa). Contains helix-turn-helix motif at aa 245-266 (Score 1140%2C+3.07 SD). Seems belong to the AraC/XylS family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3736;product=Transcriptional regulatory protein (probably AraC/XylS-family);protein_id=CCP46563.1;transl_table=11
AL123456.3	EMBL	gene	4187699	4189288	.	+	.	ID=gene-Rv3737;Name=Rv3737;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3737
AL123456.3	EMBL	CDS	4187699	4189288	.	+	0	ID=cds-CCP46564.1;Parent=gene-Rv3737;Dbxref=EnsemblGenomes-Gn:Rv3737,EnsemblGenomes-Tr:CCP46564,GOA:O69704,InterPro:IPR010619,InterPro:IPR024528,UniProtKB/TrEMBL:O69704,NCBI_GP:CCP46564.1;Name=CCP46564.1;Note=Rv3737%2C (MTV025.085)%2C len: 529 aa. Probable conserved transmembrane protein%2C similar to others and also some hypothetical proteins e.g. AAK61331|THRE threonine export carrier from Corynebacterium glutamicum (Brevibacterium flavum) (489 aa)%2C FASTA scores: opt: 773%2CE(): 1.8e-36%2C (37.25%25 identity in 424 aa overlap)%3B Q9X8J0|SCE9.17 putative membrane protein from Streptomyces coelicolor (578 aa)%2C FASTA scores: opt: 642%2C E(): 5.4e-29%2C(31.6%25 identity in 481 aa overlap) (shorter 119 aa at N-terminus)%3B Q9CJU6|PM1895 hypothetical protein from Pasteurella multocida (262 aa)%2C FASTA scores: opt: 233%2CE(): 4.1e-06%2C (25.0%25 identity in 256 aa overlap)%3B Q9S267|SCI30A.06 putative integral membrane protein from Streptomyces coelicolor (297 aa)%2C FASTA scores: opt: 163%2CE(): 0.042%2C (29.65%25 identity in 263 aa overlap)%3B etc. Also partially similar to O05435|Rv3910|MTCY15F10.01c|MTV028.01 hypothetical 123.6 KDA protein from Mycobacterium tuberculosis (1184 aa) (34.4%25 identity in 125 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3737;product=Probable conserved transmembrane protein;protein_id=CCP46564.1;transl_table=11
AL123456.3	EMBL	gene	4189285	4190232	.	-	.	ID=gene-Rv3738c;Name=PPE66;gbkey=Gene;gene=PPE66;gene_biotype=protein_coding;locus_tag=Rv3738c
AL123456.3	EMBL	CDS	4189285	4190232	.	-	0	ID=cds-CCP46565.1;Parent=gene-Rv3738c;Dbxref=EnsemblGenomes-Gn:Rv3738c,EnsemblGenomes-Tr:CCP46565,GOA:P9WHX1,InterPro:IPR000030,NCBI_GP:CCP46565.1;Name=CCP46565.1;Note=Rv3738c%2C (MTV025.086c)%2C len: 315 aa. PPE66%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa)%2CFASTA scores: opt: 464%2C E(): 2.2e-17%2C (47.05%25 identity in 338 aa overlap). Probably a continuation of the upstream ORF MTV025.87c|Rv3739c|PPE67. At position 97470-72 a stop codon is present which interrupts a possibly longer ORF%2Cobserved in related ORFs MTV012_32 or MTCY21B4_4. The sequence has been checked and no errors were detected. A similar situation%2C but with a frameshift separating the ORFs is found in MTV012_36/MTV012_35. Sequence similarity is also seen with MTCY251_15%3B MTCY261_19%3B MLCB2492_30 from Mycobacterium leprae%3B MTCY10G2_10%3B MTY21C12_9%3B MTCI125_26%3B MTCY164_36%3B MTCY6A4_1.;gbkey=CDS;gene=PPE66;locus_tag=Rv3738c;product=PPE family protein PPE66;protein_id=CCP46565.1;transl_table=11
AL123456.3	EMBL	gene	4190284	4190517	.	-	.	ID=gene-Rv3739c;Name=PPE67;gbkey=Gene;gene=PPE67;gene_biotype=protein_coding;locus_tag=Rv3739c
AL123456.3	EMBL	CDS	4190284	4190517	.	-	0	ID=cds-CCP46566.1;Parent=gene-Rv3739c;Dbxref=EnsemblGenomes-Gn:Rv3739c,EnsemblGenomes-Tr:CCP46566,InterPro:IPR000030,UniProtKB/TrEMBL:Q79FA2,NCBI_GP:CCP46566.1;Name=CCP46566.1;Note=Rv3739c%2C (MTV025.087c)%2C len: 77 aa. PPE67%2C Member of the Mycobacterium tuberculosis PE family%2C showing high homology with O53269|Rv3022c|MTV012.36c (82 aa) FASTA scores: opt: 398%2C E(): 1.2e-19%2C (74.0%25 identity in 77 aa overlap)%3B and similar to the N-termini of other PPE proteins e.g. O53265|Rv3018c|MTV012.32c (434 aa) FASTA scores: opt: 398%2C E(): 4.8e-19%2C (74.0%25 identity in 77 aa overlap). ORF ends at the stop codon at position 97470%2Cwhich is not present in similar ORFs: MTV012_32%2C or MTCY21B4_4. Sequence homology with MTV012_32%2C and MTCY21B4_4 continues in the downstream ORF MTV025.086c|Rv3738c|PPE66. Sequence was checked%2C but no errors were detected. A similar situation%2C but with a frameshift separating the ORFs%2C is found in MTV012_36/MTV012_35. Also ORF MTV025.87c shows similarity to MTV03 _14%3B MTCY6A4_1%3B MTV035_8%3B MTV037_17%3B MLCB2492_30%3B MTCY261_19%3B MTCY251_15%3B MTCY3A2_23%3B MTCY28_16%3B etc.;gbkey=CDS;gene=PPE67;locus_tag=Rv3739c;product=PPE family protein PPE67;protein_id=CCP46566.1;transl_table=11
AL123456.3	EMBL	gene	4190833	4192179	.	-	.	ID=gene-Rv3740c;Name=Rv3740c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3740c
AL123456.3	EMBL	CDS	4190833	4192179	.	-	0	ID=cds-CCP46567.1;Parent=gene-Rv3740c;Dbxref=EnsemblGenomes-Gn:Rv3740c,EnsemblGenomes-Tr:CCP46567,GOA:P9WKA5,InterPro:IPR004255,InterPro:IPR009721,InterPro:IPR014292,NCBI_GP:CCP46567.1;Name=CCP46567.1;Note=Rv3740c%2C (MTV025.088c)%2C len: 448 aa. Possible triacylglycerol synthase (See Daniel et al.%2C 2004)%2C highly similar to several other Mycobacterium tuberculosis hypothetical proteins e.g. O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa) FASTA scores: opt: 1917%2C E(): 2.3e-112%2C (61.4%25 identity in 451 aa overlap)%3B Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA scores: opt: 858%2C E(): 3.4e-46%2C (37.4%25 identity in 460 aa overlap)%3B Q10554|Y895_MYCTU|Rv0895|MT0919|MTCY31.23 (505 aa)%2C FASTA scores: opt: 767%2C E(): 1.9e-40%2C (44.3%25 identity in 467 aa overlap)%3B MTCY31_25%3B MTCY28_26%3B MTCY493_29%3B MTCY21B4_43%3B MTCY8D5_16%3B MTCY3A2_28%3B MTV013_8%3B MTY13E12_33%3B MTV013_9%3B MTY20B11_9%3B etc. Also similar to Q9RIU8|SCM11.13c hypothetical 47.1 KDA protein from Streptomyces coelicolor (446 aa)%2C FASTA scores: opt: 319%2C E(): 1.7e-12%2C (30.9%25 identity in 453 aa overlap).;gbkey=CDS;locus_tag=Rv3740c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);protein_id=CCP46567.1;transl_table=11
AL123456.3	EMBL	gene	4192179	4192853	.	-	.	ID=gene-Rv3741c;Name=Rv3741c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3741c
AL123456.3	EMBL	CDS	4192179	4192853	.	-	0	ID=cds-CCP46568.1;Parent=gene-Rv3741c;Dbxref=EnsemblGenomes-Gn:Rv3741c,EnsemblGenomes-Tr:CCP46568,GOA:O69708,UniProtKB/TrEMBL:O69708,NCBI_GP:CCP46568.1;Name=CCP46568.1;Note=Rv3741c%2C (MTV025.089c)%2C len: 224 aa. Possible oxidoreductase%2C probably combines with product of upstream ORF MTV025.090c to form a functional monooxygenase%2C highly similar to C-terminal end of various oxidoreductases e.g. Q9APW3 aromatic-ring hyroxylase from Pseudomonas aeruginosa (508 aa)%2C FASTA scores: opt: 549%2C E(): 5.9e-28%2C (56.1%25 identity in 155 aa overlap)%3B Q9A588|CC2569 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa)%2C FASTA scores: opt: 487%2C E(): 5.6e-24%2C (39.55%25 identity in 225 aa overlap)%3B Q9RZT0|DRB0033 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa)%2C FASTA scores: opt: 460%2C E(): 4.7e-22%2C (38.5%25 identity in 226 aa overlap)%3B etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 hypothetical 55.3 KDA protein (489 aa)%2C FASTA scores: opt: 542%2C E(): 1.6e-27%2C (50.0%25 identity in 162 aa overlap)%3B O53762|Rv0565c|MTV039.03c putative monoxygenase (486 aa)%2CFASTA scores: opt: 462%2C E(): 2.2e-22%2C (37.15%25 identity in 226 aa overlap)%3B O53300|Rv3083|MTV013.04 monoxygenase (495 aa)%2C FASTA scores: opt: 462%2C E(): 2.2e-22%2C (45.65%25 identity in 173 aa overlap)%3B etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in upstream ORF (MTV025.090c) after a gap of ~~100 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3741c;product=Possible oxidoreductase;protein_id=CCP46568.1;transl_table=11
AL123456.3	EMBL	gene	4192850	4193245	.	-	.	ID=gene-Rv3742c;Name=Rv3742c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3742c
AL123456.3	EMBL	CDS	4192850	4193245	.	-	0	ID=cds-CCP46569.1;Parent=gene-Rv3742c;Dbxref=EnsemblGenomes-Gn:Rv3742c,EnsemblGenomes-Tr:CCP46569,UniProtKB/TrEMBL:O69709,NCBI_GP:CCP46569.1;Name=CCP46569.1;Note=Rv3742c%2C (MTV025.090c)%2C len: 131 aa. Possible oxidoreductase%2C probably combines with product of downstream ORF MTV025.090c to form a functional monooxygenase%2C highly similar to N-terminal end of various oxidoreductases e.g. Q9A588|CC2569 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa)%2C FASTA scores: opt: 170%2C E(): 0.00048%2C (47.55%25 identity in 103 aa overlap)%3B Q9APW3 aromatic-ring hyroxylase from Pseudomonas aeruginosa (508 aa) FASTA scores: opt: 160%2CE(): 0.0022%2C (50.55%25 identity in 87 aa overlap)%3B Q9RZT0|DRB0033 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa)%2C FASTA scores: opt: 153%2C E(): 0.0097%2C(45.45%25 identity in 88 aa overlap)%3B etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 hypothetical 55.3 KDA protein (489 aa)%2C FASTA scores: opt: 140%2C E(): 0.044%2C (37.1%25 identity in 132 aa overlap)%3B O53300|Rv3083|MTV013.04 monoxygenase (495 aa) FASTA scores: opt: 133%2C E(): 0.13%2C (43.05%25 identity in 79 aa overlap)%3B O53762|Rv0565c|MTV039.03c putative monoxygenase (486 aa)%2CFASTA scores: opt: 110%2C E(): 4.1%2C (42.85%25 identity in 77 aa overlap)%3B etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in downstream ORF (MTV025.089c) after a gap of ~~100 aa.;gbkey=CDS;locus_tag=Rv3742c;product=Possible oxidoreductase;protein_id=CCP46569.1;transl_table=11
AL123456.3	EMBL	gene	4193391	4195373	.	-	.	ID=gene-Rv3743c;Name=ctpJ;gbkey=Gene;gene=ctpJ;gene_biotype=protein_coding;gene_synonym=nmtA;locus_tag=Rv3743c
AL123456.3	EMBL	CDS	4193391	4195373	.	-	0	ID=cds-CCP46570.1;Parent=gene-Rv3743c;Dbxref=EnsemblGenomes-Gn:Rv3743c,EnsemblGenomes-Tr:CCP46570,GOA:P9WPT7,InterPro:IPR001757,InterPro:IPR008250,InterPro:IPR018303,InterPro:IPR023214,InterPro:IPR023299,InterPro:IPR027256,NCBI_GP:CCP46570.1;Name=CCP46570.1;Note=Rv3743c%2C (MTV025.091c)%2C len: 660 aa. Probable ctpJ%2Ccation-transporting P-type ATPase%2C transmembrane protein highly similar to others e.g. Q9ZBF3|SC9B5.27 putative cation-transporting ATPase from Streptomyces coelicolor (638 aa)%2C FASTA scores: opt: 1635%2C E(): 2.5e-86%2C (62.25%25 identity in 63.95 aa overlap)%3B Q59997|CADA|SLR0797 cadmium-transporting ATPase from Synechocystis sp. strain PCC 6803 (642 aa)%2C FASTA scores: opt: 1474%2C E(): 4.3e-77%2C(42.4%25 identity in 604 aa overlap)%3B P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa)%2C FASTA scores: opt: 1327%2C E(): 1.3e-68%2C (36.6%25 identity in 626 aa overlap)%3B etc. Also highly similar to O53160|CTPD_MYCTU|Rv1469|MT1515|MTV007.16 probable cation-transporting P-type ATPase D from Mycobacterium tuberculosis (657 aa)%2C FASTA scores: opt: 1845%2C E(): 2.3e-98%2C (55.85%25 identity in 650 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site and PS01229 Hypothetical family signature 2. Belongs to the cation transport ATPases family (E1-E2 ATPases). Transcription is repressed by NmtR (See Cavet et al.%2C 2002).;gbkey=CDS;gene=ctpJ;inference=protein motif:PROSITE:PS01229;locus_tag=Rv3743c;product=Probable cation transporter P-type ATPase CtpJ;protein_id=CCP46570.1;transl_table=11
AL123456.3	EMBL	gene	4195440	4195802	.	+	.	ID=gene-Rv3744;Name=nmtR;gbkey=Gene;gene=nmtR;gene_biotype=protein_coding;locus_tag=Rv3744
AL123456.3	EMBL	CDS	4195440	4195802	.	+	0	ID=cds-CCP46571.1;Parent=gene-Rv3744;Dbxref=EnsemblGenomes-Gn:Rv3744,EnsemblGenomes-Tr:CCP46571,GOA:O69711,InterPro:IPR001845,InterPro:IPR011991,NCBI_GP:CCP46571.1;Name=CCP46571.1;Note=Rv3744%2C (MTV025.092)%2C len: 120 aa. Transcriptional regulator nmtR (See Cavet et al.%2C 2002). Highly similar to many e.g. Q9ZBF4|SC9B5.26c from Streptomyces coelicolor (120 aa)%2C FASTA scores: opt: 480%2C E(): 2.4e-24%2C (63.25%25 identity in 117 aa overlap)%3B O31844|YOZA YOZA regulator from Bacillus subtilis (107 aa)%2C FASTA scores: opt: 249%2CE(): 1.6e-09%2C (44.8%25 identity in 96 aa overlap)%3B P30340|SMTB_SYNP7|SMTB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (122 aa)%2C FASTA scores: opt: 230%2C E(): 2.9e-08%2C (46.0%25 identity in 87 aa overlap)%3B etc. Equivalent to AAK48216 from Mycobacterium tuberculosis strain CDC1551 (135 aa) but shorter 15 aa. Also similar to MTCY27_22%3B MTCY39_25%3B and MTCY441_12. Contains helix-turn-helix motif at aa 47-68 (Score 1815%2C +5.37 SD). Belongs to the ArsR-SmtB family of transcriptional regulators.;gbkey=CDS;gene=nmtR;locus_tag=Rv3744;product=Metal sensor transcriptional regulator (ArsR-SmtB family);protein_id=CCP46571.1;transl_table=11
AL123456.3	EMBL	gene	4195886	4196098	.	-	.	ID=gene-Rv3745c;Name=Rv3745c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3745c
AL123456.3	EMBL	CDS	4195886	4196098	.	-	0	ID=cds-CCP46572.1;Parent=gene-Rv3745c;Dbxref=EnsemblGenomes-Gn:Rv3745c,EnsemblGenomes-Tr:CCP46572,InterPro:IPR018714,UniProtKB/TrEMBL:O69712,NCBI_GP:CCP46572.1;Name=CCP46572.1;Note=Rv3745c%2C (MTV025.093c)%2C len: 70 aa. Conserved hypothetical protein%2C highly similar to others e.g. N-terminus of Q9X4E6 hypothetical 13.4 KDA protein from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (124 aa)%2C FASTA scores: opt: 279%2C E(): 4.4e-14%2C (59.4%25 identity in 69 aa overlap)%3B N-terminus of Q9A2A6|CC3660 hypothetical protein from Caulobacter crescentus (172 aa) FASTA scores: opt: 272%2C E(): 1.9e-13%2C (63.35%25 identity in 60 aa overlap)%3B N-terminus of P74345|SLR1628 hypothetical 14.5 KDA protein from Synechocystis sp. strain PCC 6803 (134 aa)%2C FASTA scores: opt: 233%2C E(): 1.3e-10%2C (54.85%25 identity in 62 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3745c;product=Conserved hypothetical protein;protein_id=CCP46572.1;transl_table=11
AL123456.3	EMBL	gene	4196171	4196506	.	-	.	ID=gene-Rv3746c;Name=PE34;gbkey=Gene;gene=PE34;gene_biotype=protein_coding;locus_tag=Rv3746c
AL123456.3	EMBL	CDS	4196171	4196506	.	-	0	ID=cds-CCP46573.1;Parent=gene-Rv3746c;Dbxref=EnsemblGenomes-Gn:Rv3746c,EnsemblGenomes-Tr:CCP46573,InterPro:IPR000084,UniProtKB/TrEMBL:Q79FA1,NCBI_GP:CCP46573.1;Name=CCP46573.1;Note=Rv3746c%2C (MTV025.094c)%2C len: 111 aa. PE34%2C Probable member of the Mycobacterium tuberculosis PE family (see citation below)%2C but without the glycine-rich C-terminal part%2C similar to N-termini of many e.g. O69737|Rv3872|MTV027.07 (99 aa) FASTA scores: opt: 306%2CE(): 1e-13%2C (50.5%25 identity in 99 aa overlap)%3B O53215|Rv2490c|MTV008.46 (1660 aa) FASTA scores: opt: 125%2CE(): 0.99%2C (34.25%25 identity in 111 aa overlap). Also weakly similar to MTV008_46%3B MTCI418B_6%3B MTCY130_1%3B MTY25D10_11%3B MTCY1A11_25%3B MTCY21B4_13%3B MTCY21B4_27%3B MTCY493_2%3B MTCY28_25%3B etc.;gbkey=CDS;gene=PE34;locus_tag=Rv3746c;product=Probable PE family protein PE34 (PE family-related protein);protein_id=CCP46573.1;transl_table=11
AL123456.3	EMBL	gene	4196724	4197107	.	+	.	ID=gene-Rv3747;Name=Rv3747;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3747
AL123456.3	EMBL	CDS	4196724	4197107	.	+	0	ID=cds-CCP46574.1;Parent=gene-Rv3747;Dbxref=EnsemblGenomes-Gn:Rv3747,EnsemblGenomes-Tr:CCP46574,UniProtKB/TrEMBL:O69714,NCBI_GP:CCP46574.1;Name=CCP46574.1;Note=Rv3747%2C (MTV025.095)%2C len: 127 aa. Conserved protein%2C highly similar to downstream ORF O69715|Rv3748|MTV025.096 conserved hypothetical protein (119 aa)%2C FASTA scores: opt: 494%2C E(): 6e-27%2C (64.4%25 identity in 118 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3747;product=Conserved protein;protein_id=CCP46574.1;transl_table=11
AL123456.3	EMBL	gene	4197236	4197595	.	+	.	ID=gene-Rv3748;Name=Rv3748;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3748
AL123456.3	EMBL	CDS	4197236	4197595	.	+	0	ID=cds-CCP46575.1;Parent=gene-Rv3748;Dbxref=EnsemblGenomes-Gn:Rv3748,EnsemblGenomes-Tr:CCP46575,UniProtKB/TrEMBL:O69715,NCBI_GP:CCP46575.1;Name=CCP46575.1;Note=Rv3748%2C (MTV025.096)%2C len: 119 aa. Hypothetical protein%2C highly similar to upstream ORF O69714|Rv3747|MTV025.095 conserved hypothetical protein (127 aa)%2C FASTA scores: opt: 496%2C E(): 2.5e-28%2C (64.4%25 identity in 118 aa overlap).;gbkey=CDS;locus_tag=Rv3748;product=Conserved hypothetical protein;protein_id=CCP46575.1;transl_table=11
AL123456.3	EMBL	gene	4197628	4198137	.	-	.	ID=gene-Rv3749c;Name=Rv3749c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3749c
AL123456.3	EMBL	CDS	4197628	4198137	.	-	0	ID=cds-CCP46576.1;Parent=gene-Rv3749c;Dbxref=EnsemblGenomes-Gn:Rv3749c,EnsemblGenomes-Tr:CCP46576,UniProtKB/TrEMBL:L0TGF0,NCBI_GP:CCP46576.1;Name=CCP46576.1;Note=Rv3749c%2C (MTV025.097c)%2C len: 169 aa. Hypothetical protein%2C showing some similarity with O85864 hypothetical 21.4 KDA protein from Sphingomonas aromaticivorans plasmid pNL1 (196 aa)%2C FASTA scores: opt: 148%2C E(): 0.011%2C (32.7%25 identity in 104 aa overlap)%3B Q9LCU6 hypothetical 21.2 KDA protein from Arthrobacter sp. TM1 (192 aa)%2C FASTA scores: opt: 125%2C E(): 0.35%2C (31.5%25 identity in 92 aa overlap)%3B Q9L631|SPCB myo-inositol-2-dehydrogenase from Streptomyces spectabilis (374 aa)%3B Q9WJP8|PRE-S1 PRE-S1 protein (fragment) from Hepatitis B virus (88 aa)%3B etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Predicted to be an outer membrane protein (See Song et al.%2C2008). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;inference=protein motif:PROSITE:PS00092;locus_tag=Rv3749c;product=Conserved hypothetical protein;protein_id=CCP46576.1;transl_table=11
AL123456.3	EMBL	gene	4198205	4198597	.	-	.	ID=gene-Rv3750c;Name=Rv3750c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3750c
AL123456.3	EMBL	CDS	4198205	4198597	.	-	0	ID=cds-CCP46577.1;Parent=gene-Rv3750c;Dbxref=EnsemblGenomes-Gn:Rv3750c,EnsemblGenomes-Tr:CCP46577,GOA:O69717,InterPro:IPR009061,InterPro:IPR010093,UniProtKB/TrEMBL:O69717,NCBI_GP:CCP46577.1;Name=CCP46577.1;Note=Rv3750c%2C (MTV025.098c)%2C len: 130 aa. Possible excisionase%2C similar to others e.g. Q9LCU5 putative excisionase from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 297%2C E(): 1.2e-12%2C (40.35%25 identity in 114 aa overlap)%3B O85865 putative excisionase from Sphingomonas aromaticivorans plasmid pNL1 (152 aa)%2C FASTA scores: opt: 223%2C E(): 7.3e-08%2C (39.15%25 identity in 97 aa overlap)%3B Q9XBH1|xis excisionase from Bacteroides fragilis (124 aa) FASTA scores: opt: 128%2C E(): 0.1%2C (30.7%25 identity in 88 aa overlap)%3B etc. Also some similarity to transcriptional regulators. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c (114 aa) FASTA scores: opt: 224%2C E(): 4.9e-08%2C (42.7%25 identity in 82 aa overlap). Contains helix-turn-helix motif at aa 55-76 (Score 1925%2C+5.74 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;gbkey=CDS;locus_tag=Rv3750c;product=Possible excisionase;protein_id=CCP46577.1;transl_table=11
AL123456.3	EMBL	gene	4198874	4199089	.	+	.	ID=gene-Rv3751;Name=Rv3751;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3751
AL123456.3	EMBL	CDS	4198874	4199089	.	+	0	ID=cds-CCP46578.1;Parent=gene-Rv3751;Dbxref=EnsemblGenomes-Gn:Rv3751,EnsemblGenomes-Tr:CCP46578,GOA:O69718,InterPro:IPR002104,InterPro:IPR011010,InterPro:IPR013762,UniProtKB/TrEMBL:O69718,NCBI_GP:CCP46578.1;Name=CCP46578.1;Note=Rv3751%2C (MTV025.099)%2C len: 71 aa. Probable integrase (fragment)%2C similar to part of many e.g. Q48908 integrase (fragment) from Mycobacterium paratuberculosis (191 aa)%2CFASTA scores: opt: 206%2C E(): 5.5e-08%2C (57.65%25 identity in 59 aa overlap)%3B Q9ZWV7|int integrase from Corynephage 304L (395 aa)%2C FASTA scores: opt: 156%2C E(): 0.00036%2C (45.75%25 identity in 59 aa overlap)%3B Q9K722|BH3551 integrase (phage-related protein) from Bacillus halodurans (378 aa)%2CFASTA scores: opt: 151%2C E(): 0.00079%2C (46.15%25 identity in 52 aa overlap)%3B etc. Also similarity with various conjugative transposons. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. P71903|Rv2309c|MTCY3G12.25 (151 aa)%2C FASTA scores: opt: 193%2C E(): 3.8e-07%2C (50.85%25 identity in 59 aa overlap)%3B O53403|Rv1055|MTV017.08 (78 aa)%2C FASTA scores: opt: 171%2CE(): 7.8e-06%2C (54.15%25 identity in 48 aa overlap)%3B etc. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3751;product=Probable integrase (fragment);protein_id=CCP46578.1;transl_table=11
AL123456.3	EMBL	gene	4199131	4199217	.	-	.	ID=gene-serX;Name=serX;gbkey=Gene;gene=serX;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	4199131	4199217	.	-	.	ID=rna-serX;Parent=gene-serX;Note=codon recognized: UCG%3B serX%2C tRNA-Ser%2C anticodon cga%2C length %3D 87. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;anticodon=(pos:complement(4199181..4199183));gbkey=tRNA;gene=serX;product=tRNA-Ser
AL123456.3	EMBL	exon	4199131	4199217	.	-	.	ID=exon-serX-1;Parent=rna-serX;Note=codon recognized: UCG%3B serX%2C tRNA-Ser%2C anticodon cga%2C length %3D 87. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;anticodon=(pos:complement(4199181..4199183));gbkey=tRNA;gene=serX;product=tRNA-Ser
AL123456.3	EMBL	gene	4199247	4199705	.	-	.	ID=gene-Rv3752c;Name=Rv3752c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3752c
AL123456.3	EMBL	CDS	4199247	4199705	.	-	0	ID=cds-CCP46579.1;Parent=gene-Rv3752c;Dbxref=EnsemblGenomes-Gn:Rv3752c,EnsemblGenomes-Tr:CCP46579,GOA:O69719,InterPro:IPR002125,InterPro:IPR016192,InterPro:IPR016193,InterPro:IPR028883,UniProtKB/TrEMBL:O69719,NCBI_GP:CCP46579.1;Name=CCP46579.1;Note=Rv3752c%2C (MTV025.100c)%2C len: 152 aa. Probable cytidine/deoxycytidylate deaminase%2C equivalent to Q9CB32|ML2474 possible cytidine/deoxycytidylate deaminase from Mycobacterium leprae (171 aa)%2C FASTA scores: opt: 890%2CE(): 1.6e-50%2C (88.1%25 identity in 151 aa overlap). Also highly similar to other deaminases and hypothetical proteins e.g. Q9AK79|2SCD60.04c putative deaminase from Streptomyces coelicolor (143 aa)%2C FASTA scores: opt: 559%2CE(): 2.9e-29%2C (66.45%25 identity in 146 aa overlap)%3B Q9F9W7 cytosine deaminase from Bifidobacterium longum (143 aa) FASTA scores: opt: 512%2C E(): 3.1e-26%2C (54.85%25 identity in 144 aa overlap)%3B P21335|YAAJ_BACSU hypothetical 17.8 KDA protein from Bacillus subtilis (161 aa)%2C FASTA scores: opt: 425%2C E(): 1.4e-20%2C (47.7%25 identity in 151 aa overlap)%3B AAK74212|SP0020 cytidine/deoxycytidylate deaminase family protein from Streptococcus pneumoniae (155 aa)%2C FASTA scores: opt: 401%2C E(): 4.7e-19%2C (46.25%25 identity in 147 aa overlap)%3B P30134|YFHC_ECOLI|B2559 hypothetical 20.0 KDA protein from Escherichia coli strain K12 (178 aa)%2C FASTA scores: opt: 397%2C E(): 9.5e-19%2C (47.0%25 identity in 149 aa overlap)%3B etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. Belongs to the cytidine and deoxycytidylate deaminases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00903;locus_tag=Rv3752c;product=Possible cytidine/deoxycytidylate deaminase;protein_id=CCP46579.1;transl_table=11
AL123456.3	EMBL	gene	4199721	4200221	.	-	.	ID=gene-Rv3753c;Name=Rv3753c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3753c
AL123456.3	EMBL	CDS	4199721	4200221	.	-	0	ID=cds-CCP46580.1;Parent=gene-Rv3753c;Dbxref=EnsemblGenomes-Gn:Rv3753c,EnsemblGenomes-Tr:CCP46580,InterPro:IPR023869,UniProtKB/TrEMBL:O69720,NCBI_GP:CCP46580.1;Name=CCP46580.1;Note=Rv3753c%2C (MTV025.101c)%2C len: 166 aa. Conserved protein%2C only equivalent to Q9CB33|ML2473 hypothetical protein from Mycobacterium leprae (159 aa) FASTA scores: opt: 920 E(): 1.4e-52%2C%2C (88.6%25 identity in 158 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3753c;product=Conserved protein;protein_id=CCP46580.1;transl_table=11
AL123456.3	EMBL	gene	4200421	4201326	.	+	.	ID=gene-Rv3754;Name=tyrA;gbkey=Gene;gene=tyrA;gene_biotype=protein_coding;locus_tag=Rv3754
AL123456.3	EMBL	CDS	4200421	4201326	.	+	0	ID=cds-CCP46581.1;Parent=gene-Rv3754;Dbxref=EnsemblGenomes-Gn:Rv3754,EnsemblGenomes-Tr:CCP46581,GOA:O69721,InterPro:IPR003099,InterPro:IPR008927,InterPro:IPR016040,UniProtKB/TrEMBL:O69721,NCBI_GP:CCP46581.1;Name=CCP46581.1;Note=Rv3754%2C (MTV025.102)%2C len: 301 aa. Probable tyrA%2Cprephenate dehydrogenase%2C equivalent%2C but shorter 27 aa%2C to Q9CB34|ML2472 possible prephenate dehydrogenase from Mycobacterium leprae (327 aa) FASTA scores: opt: 1600%2C E(): 1.6e-89%2C (80.0%25 identity in 300 aa overlap). Also similar to many pephenate dehydrogenases e.g. Q9RND8|TYRA from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (299 aa)%2C FASTA scores: opt: 345%2C E(): 9.7e-14%2C (32.85%25 identity in 271 aa overlap)%3B Q9RVA7|DR1122 from Deinococcus radiodurans (372 aa) FASTA scores: opt: 341%2C E(): 2e-13%2C(35.65%25 identity in 216 aa overlap)%3B P20692|TYRA_BACSU from Bacillus subtilis (372 aa)%2C FASTA scores: opt: 314%2C E(): 8.6e-12%2C (27.75%25 identity in 263 aa overlap)%3B etc. Also similar to Q04983|TYRC_ZYMMO TYRC protein [includes: cyclohexadienyl dehydrogenase and prephenate dehydrogenase activities] from Zymomonas mobilis (293 aa)%2C FASTA scores: opt: 290%2C E(): 2e-10%2C (30.15%25 identity in 239 aa overlap). Equivalent to AAK48225 from Mycobacterium tuberculosis strain CDC1551 (323 aa) but shorter 22 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tyrA;locus_tag=Rv3754;product=Prephenate dehydrogenase TyrA (PDH) (hydroxyphenylpyruvate synthase);protein_id=CCP46581.1;transl_table=11
AL123456.3	EMBL	gene	4201289	4201888	.	-	.	ID=gene-Rv3755c;Name=Rv3755c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3755c
AL123456.3	EMBL	CDS	4201289	4201888	.	-	0	ID=cds-CCP46582.1;Parent=gene-Rv3755c;Dbxref=EnsemblGenomes-Gn:Rv3755c,EnsemblGenomes-Tr:CCP46582,InterPro:IPR009467,UniProtKB/TrEMBL:O86358,NCBI_GP:CCP46582.1;Name=CCP46582.1;Note=Rv3755c%2C (MTV025.103c)%2C len: 199 aa. Conserved protein showing similarity to CAC47343|SMC03980 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (196 aa) FASTA scores: opt: 244%2C E(): 4.1e-09%2C(30.9%25 identity in 191 aa overlap)%3B Q9I2B5|PA1994 from Pseudomonas aeruginosa (187 aa)%2C FASTA scores: opt: 226%2CE(): 6e-08%2C (29.9%25 identity in 194 aa overlap)%3B and Q98N73|MLR0268 hypothetical protein (183 aa)%2C FASTA scores: opt: 234%2C E(): 1.8e-08%2C (27.05%25 identity in 185 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3755c;product=Conserved protein;protein_id=CCP46582.1;transl_table=11
AL123456.3	EMBL	gene	4201894	4202613	.	-	.	ID=gene-Rv3756c;Name=proZ;gbkey=Gene;gene=proZ;gene_biotype=protein_coding;locus_tag=Rv3756c
AL123456.3	EMBL	CDS	4201894	4202613	.	-	0	ID=cds-CCP46583.1;Parent=gene-Rv3756c;Dbxref=EnsemblGenomes-Gn:Rv3756c,EnsemblGenomes-Tr:CCP46583,GOA:O69722,InterPro:IPR000515,UniProtKB/TrEMBL:O69722,NCBI_GP:CCP46583.1;Name=CCP46583.1;Note=Rv3756c%2C (MTV025.104c)%2C len: 239 aa. Possible proZ%2Cosmoprotectant transport integral membrane protein ABC transporter (see citation below)%2C similar to osmoprotection proteins (proW%2C proZ) involved in glycine betaine/L-proline/choline transport%2C e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB protein (probable glycine betaine/carnitine/choline ABC transporter) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434%2C E(): 2.5e-18%2C (36.6%25 identity in 194 aa overlap)%3B Q45461|OPBB_BACSU|OPUBB|prow choline transport system permease protein (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa)%2C FASTA scores: opt: 402%2C E(): 1.9e-16%2C (32.0%25 identity in 203 aa overlap)%3B O34878|OPCB_BACSU|OPUCB glycine betaine/carnitine/choline transport system permease protein from Bacillus subtilis (217 aa)%2C FASTA scores: opt: 385%2C E(): 1.8e-15%2C (30.2%25 identity in 222 aa overlap)%3B P39775|O34657|OPUBD|PROZ|OPBD_BACSU choline transport system permease protein from Bacillus subtilis (226 aa) FASTA scores: opt: 350%2C E(): 2e-13%2C (31.75%25 identity in 208 aa overlap)%3B etc. Could belong to the CYSTW subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=proZ;locus_tag=Rv3756c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ;protein_id=CCP46583.1;transl_table=11
AL123456.3	EMBL	gene	4202610	4203299	.	-	.	ID=gene-Rv3757c;Name=proW;gbkey=Gene;gene=proW;gene_biotype=protein_coding;locus_tag=Rv3757c
AL123456.3	EMBL	CDS	4202610	4203299	.	-	0	ID=cds-CCP46584.1;Parent=gene-Rv3757c;Dbxref=EnsemblGenomes-Gn:Rv3757c,EnsemblGenomes-Tr:CCP46584,GOA:O69723,InterPro:IPR000515,UniProtKB/TrEMBL:O69723,NCBI_GP:CCP46584.1;Name=CCP46584.1;Note=Rv3757c%2C (MTV025.105c)%2C len: 229 aa. Possible proW%2Cosmoprotectant transport integral membrane protein ABC transporter (see citation below)%2C similar to osmoprotection proteins (proW%2C proZ) involved in glycine betaine/L-proline/choline transport%2C e.g. BAB58607|Q99RI6|OPUCD|SA2234|SAV2445 OPUCD protein (probable glycine betaine/carnitine/choline ABC transporter) from Staphylococcus aureus (231 aa) FASTA scores: opt: 364%2C E(): 7.1e-15%2C (30.0%25 identity in 220 aa overlap)%3B Q45461|OPBB_BACSU|OPUBB|prow choline transport system permease protein (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa)%2C FASTA scores: opt: 348%2C E(): 6.2e-14%2C (31.05%25 identity in 206 aa overlap)%3B O34878|OPCB_BACSU|OPUCB glycine betaine/carnitine/choline transport system permease protein from Bacillus subtilis (217 aa)%2C FASTA scores: opt: 343%2C E(): 1.2e-13%2C (30.1%25 identity in 206 aa overlap)%3B O34742|OPCD_BACSU|OPUCD glycine betaine/carnitine/choline transport system permease protein from Bacillus subtilis (229 aa) FASTA scores: opt: 337%2C E(): 2.9e-13%2C (31.1%25 identity in 193 aa overlap)%3B etc. Could belong to the CYSTW subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=proW;locus_tag=Rv3757c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW;protein_id=CCP46584.1;transl_table=11
AL123456.3	EMBL	gene	4203287	4204417	.	-	.	ID=gene-Rv3758c;Name=proV;gbkey=Gene;gene=proV;gene_biotype=protein_coding;locus_tag=Rv3758c
AL123456.3	EMBL	CDS	4203287	4204417	.	-	0	ID=cds-CCP46585.1;Parent=gene-Rv3758c;Dbxref=EnsemblGenomes-Gn:Rv3758c,EnsemblGenomes-Tr:CCP46585,GOA:O69724,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR017871,InterPro:IPR027417,UniProtKB/TrEMBL:O69724,NCBI_GP:CCP46585.1;Name=CCP46585.1;Note=Rv3758c%2C (MTV025.106c)%2C len: 376 aa. Possible proV%2Cosmoprotectant transport ATP-binding protein ABC transporter (see citation below)%2C highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport%2C e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 glycine betaine/carnitine/choline ABC transporter (ATP-binding) from Staphylococcus aureus (410 aa)%2C FASTA scores: opt: 816%2C E(): 8.4e-39%2C (39.5%25 identity in 362 aa overlap)%3B O34992|OPCA_BACSU|OPUCA glycine betaine/carnitine/choline transport ATP-binding protein from Bacillus subtilis (380 aa)%2C FASTA scores: opt: 807%2C E(): 2.5e-38%2C (40.55%25 identity in 333 aa overlap)%3B Q45460|OPBA_BACSU|OPUBA|prov choline transport ATP-binding protein from Bacillus subtilis (381 aa)%2C FASTA scores: opt: 801%2C E(): 5.6e-38%2C (40.65%25 identity in 337 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporter family signature. Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=proV;inference=protein motif:PROSITE:PS00211;locus_tag=Rv3758c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV;protein_id=CCP46585.1;transl_table=11
AL123456.3	EMBL	gene	4204426	4205373	.	-	.	ID=gene-Rv3759c;Name=proX;gbkey=Gene;gene=proX;gene_biotype=protein_coding;locus_tag=Rv3759c
AL123456.3	EMBL	CDS	4204426	4205373	.	-	0	ID=cds-CCP46586.1;Parent=gene-Rv3759c;Dbxref=EnsemblGenomes-Gn:Rv3759c,EnsemblGenomes-Tr:CCP46586,GOA:O69725,InterPro:IPR007210,UniProtKB/TrEMBL:O69725,NCBI_GP:CCP46586.1;Name=CCP46586.1;Note=Rv3759c%2C (MTV025.107c)%2C len: 315 aa. Possible proX%2Cosmoprotectant-binding lipoprotein component of osmoprotectant transport system (see citation below)%2Csimilar to osmoprotection proteins (proX) involved in glycine betaine/L-proline/choline transport%2C e.g. AAK79442|CAC1474 proline/glycine betaine ABC transport system periplasmic component from Clostridium acetobutylicum (303 aa)%2C FASTA scores: opt: 308%2C E(): 1.2e-11%2C (27.4%25 identity in 314 aa overlap)%3B Q9X4J2|PROXL|SCE19A.33 PROXL protein from Streptomyces coelicolor (322 aa)%2C FASTA scores: opt: 302%2C E(): 3e-11%2C(27.2%25 identity in 327 aa overlap)%3B O29280|AF0982 osmoprotection protein (PROX) from Archaeoglobus fulgidus (292 aa)%2C FASTA scores: opt: 235%2C E(): 3.4e-07%2C (23.15%25 identity in 285 aa overlap)%3B etc. Also similar to MTV006_16 hypothetical protein from Mycobacterium tuberculosis%2C and MLU15180_43 hypothetical protein from Mycobacterium leprae. Equivalent to AAK48230 from Mycobacterium tuberculosis strain CDC1551 (343 aa) but shorter 28 aa. Contains probable N-terminal signal sequence.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=proX;locus_tag=Rv3759c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX;protein_id=CCP46586.1;transl_table=11
AL123456.3	EMBL	gene	4205538	4205840	.	+	.	ID=gene-Rv3760;Name=Rv3760;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3760
AL123456.3	EMBL	CDS	4205538	4205840	.	+	0	ID=cds-CCP46587.1;Parent=gene-Rv3760;Dbxref=EnsemblGenomes-Gn:Rv3760,EnsemblGenomes-Tr:CCP46587,GOA:O69726,InterPro:IPR010445,NCBI_GP:CCP46587.1;Name=CCP46587.1;Note=Rv3760%2C (MTV025.108)%2C len: 100 aa. Possible conserved membrane protein%2C equivalent to Q50094|ML2366|MLCB12.11c putative membrane protein from Mycobacterium leprae (113 aa)%2C FASTA scores: opt: 423%2C E(): 1.2e-20%2C (67.7%25 identity in 99 aa overlap). Also similar with Q9JST1|NMA2149 putative inner membrane hypothetical protein from Neisseria meningitidis (serogroup A) (104 aa)%2CFASTA scores: opt: 113%2C E(): 0.95%2C (33.85%25 identity in 62 aa overlap)%3B and showing similarity with Q9ZAX7 ABC transporter membrane protein subunit from Streptococcus mutans (498 aa)%2C FASTA scores: opt: 108%2C E(): 6.7%2C (42.35%25 identity in 85 aa overlap) (similarity at C-terminus)%3B and P33108|SECY_MICLU preprotein translocase SECY subunit from Micrococcus luteus (Micrococcus lysodeikticus) (436 aa)%2CFASTA scores: opt: 106%2C E(): 8.2%2C (29.05%25 identity in 86 aa overlap). Equivalent to AAK48231 from Mycobacterium tuberculosis strain CDC1551 (117 aa) but shorter 17 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3760;product=Possible conserved membrane protein;protein_id=CCP46587.1;transl_table=11
AL123456.3	EMBL	gene	4205862	4206917	.	-	.	ID=gene-Rv3761c;Name=fadE36;gbkey=Gene;gene=fadE36;gene_biotype=protein_coding;locus_tag=Rv3761c
AL123456.3	EMBL	CDS	4205862	4206917	.	-	0	ID=cds-CCP46588.1;Parent=gene-Rv3761c;Dbxref=EnsemblGenomes-Gn:Rv3761c,EnsemblGenomes-Tr:CCP46588,GOA:O69727,InterPro:IPR002575,InterPro:IPR011009,UniProtKB/TrEMBL:O69727,NCBI_GP:CCP46588.1;Name=CCP46588.1;Note=Rv3761c%2C (MTV025.109c)%2C len: 351 aa. Possible fadE36%2C acyl-CoA dehydrogenase%2C similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases%2C e.g. Q9APX7|FADE36 FADE36 protein from Pseudomonas aeruginosa (360 aa)%2C FASTA scores: opt: 147%2C E(): 0.046%2C (26.15%25 identity in 214 aa overlap)%3B part of AAB52261.2|U97002 protein similar to acyl-CoA dehydrogenases and epoxide hydrolases from Caenorhabditis elegans (985 aa)%2C FASTA score: (31.2%25 identity in 324 aa overlap). C-terminal part is highly similar to Q50095|U1740AK|MLU15183_45 hypothetical protein from Mycobacterium leprae cosmid B174 (122 aa)%2C FASTA scores: opt: 341%2C E(): 7.3e-15%2C (57.6%25 identity in 99 aa overlap). Contains PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE36;inference=protein motif:PROSITE:PS00339;locus_tag=Rv3761c;product=Possible acyl-CoA dehydrogenase FadE36;protein_id=CCP46588.1;transl_table=11
AL123456.3	EMBL	gene	4206996	4208876	.	-	.	ID=gene-Rv3762c;Name=Rv3762c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3762c
AL123456.3	EMBL	CDS	4206996	4208876	.	-	0	ID=cds-CCP46589.1;Parent=gene-Rv3762c;Dbxref=EnsemblGenomes-Gn:Rv3762c,EnsemblGenomes-Tr:CCP46589,GOA:O69728,InterPro:IPR001279,InterPro:IPR003033,InterPro:IPR029228,InterPro:IPR029229,UniProtKB/TrEMBL:O69728,NCBI_GP:CCP46589.1;Name=CCP46589.1;Note=Rv3762c%2C (MTV025.110c)%2C len: 626 aa. Possible hydrolase%2C highly similar to hypothetical proteins and beta-lactamases e.g. Q9RL04|SC5G9.23 hypothetical 70.3 KDA protein from Streptomyces coelicolor (648 aa)%2C FASTA scores: opt: 2088%2C E(): 3.7e-124%2C (52.9%25 identity in 624 aa overlap)%3B P32717|YJCS_ECOLI|B4083 hypothetical 73.2 KDA protein from Escherichia coli strain K12 (661 aa)%2C FASTA scores: opt: 1911%2C E(): 5.7e-113%2C (46.9%25 identity in 631 aa overlap)%3B Q9A824|CC1540 metallo-beta-lactamase family protein from Caulobacter crescentus (647 aa)%2C FASTA scores: opt: 1891%2C E(): 1e-111%2C (48.55%25 identity in 628 aa overlap)%3B Q08347|YOL164W chromosome xv reading frame ORF from Saccharomyces cerevisiae (Baker's yeast) (646 aa) FASTA scores: opt: 1829%2C E(): 8.4e-108%2C (45.7%25 identity in 615 aa overlap)%3B Q9I5I9|PA0740 probable beta-lactamase from Pseudomonas aeruginosa (658 aa)%2C FASTA scores: opt: 1699%2CE(): 1.4e-99%2C (43.15%25 identity in 630 aa overlap)%3B Q52556|SDSA alkyl sulfatase (protein involved in the degradation of sulfate esters of long-chain primaryal cohols e.g. SDS sodium dodecyl sulfate) from Pseudomonas sp (528 aa)%2C FASTA scores: opt: 841%2C E(): 1.7e-45%2C (33.7%25 identity in 534 aa overlap)%3B etc. N-terminual end also highly similar to Q48790|SEPA SEPA protein (protein implicated in cell separation) from Listeria monocytogenes (391 aa)%2C FASTA scores: opt: 1256%2C E(): 8.3e-72%2C (49.6%25 identity in 363 aa overlap). Also slight similarity to P96253|Rv0407|MTCY22G10.03 hypothetical 37.0 KDA protein from Mycobacterium tuberculosis (336 aa).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3762c;product=Possible hydrolase;protein_id=CCP46589.1;transl_table=11
AL123456.3	EMBL	gene	4209047	4209526	.	+	.	ID=gene-Rv3763;Name=lpqH;gbkey=Gene;gene=lpqH;gene_biotype=protein_coding;locus_tag=Rv3763
AL123456.3	EMBL	CDS	4209047	4209526	.	+	0	ID=cds-CCP46590.1;Parent=gene-Rv3763;Dbxref=EnsemblGenomes-Gn:Rv3763,EnsemblGenomes-Tr:CCP46590,GOA:P9WK61,InterPro:IPR008691,NCBI_GP:CCP46590.1;Name=CCP46590.1;Note=Rv3763%2C (MTV025.111)%2C len: 159 aa. LpqH%2C conserved 19 KDa lipoprotein antigen precursor (see citations below)%2Cequivalent to P31502|19KD_MYCIT|MI22 19 KDA lipoprotein antigen precursor (MI22 antigen) from Mycobacterium intracellulare (162 aa)%2C FASTA scores: opt: 773%2C E(): 6.2e-35%2C 75.95(%25 identity in 162 aa overlap)%3B P46733|19KD_MYCAV 19 KDA lipoprotein antigen precursor from Mycobacterium avium (161 aa)%2C FASTA scores: opt: 743%2C E(): 2.5e-33%2C (72.5%25 identity in 160 aa overlap)%3B and Q9X7A5|LPQH|ML1966 possible lipoprotein from Mycobacterium leprae FASTA scores: opt: 371%2C E(): 2.2e-13%2C (42.6%25 identity in 162 aa overlap). Possibly attached to the membrane by a lipid anchor. Similar to other mycobacterium 19 KDA antigen. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lpqH;inference=protein motif:PROSITE:PS00013;locus_tag=Rv3763;product=19 kDa lipoprotein antigen precursor LpqH;protein_id=CCP46590.1;transl_table=11
AL123456.3	EMBL	gene	4209582	4211009	.	-	.	ID=gene-Rv3764c;Name=tcrY;gbkey=Gene;gene=tcrY;gene_biotype=protein_coding;locus_tag=Rv3764c
AL123456.3	EMBL	CDS	4209582	4211009	.	-	0	ID=cds-CCP46591.1;Parent=gene-Rv3764c;Dbxref=EnsemblGenomes-Gn:Rv3764c,EnsemblGenomes-Tr:CCP46591,GOA:O69729,InterPro:IPR003594,InterPro:IPR003660,InterPro:IPR003661,InterPro:IPR004358,InterPro:IPR005467,InterPro:IPR009082,NCBI_GP:CCP46591.1;Name=CCP46591.1;Note=Rv3764c%2C (MTV025.112c)%2C len: 475 aa. Possible tcrY%2Chistidine protein kinase%2C part of a two-component regulatory system%2C similar to others e.g. Q9ADN6|2SC10A7.25 putative two component system histidine kinase from Streptomyces coelicolor (524 aa)%2C FASTA scores: opt: 1332%2CE(): 5.4e-70%2C (49.9%25 identity in 477 aa overlap)%3B Q9L3C1|KB|CAC42479 putative histidine kinase from Amycolatopsis mediterranei (469 aa)%2C FASTA scores: opt: 515%2C E(): 1.4e-22%2C (36.1%25 identity in 313 aa overlap)%3B P72560 histidine protein kinase from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (438 aa)%2C FASTA scores: opt: 480%2C E(): 1.4e-20%2C (40.1%25 identity in 232 aa overlap)%3B P30847|P76401|BAES_ECOLI|B2078 sensor protein from Escherichia coli strain K12 (467 aa)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. P96368|Rv1032c|MTCY10G2.17 (509 aa)%2C FASTA scores: opt: 1007%2C E(): 4e-51%2C (43.5%25 identity in 416 aa overlap)%3B and P71815|Rv0758|MTCY369.03 (485 aa)%2C FASTA scores: opt: 738%2CE(): 1.6e-35%2C (28.6%25 identity in 438 aa overlap). Equivalent to AAK48235 from Mycobacterium tuberculosis strain CDC1551 (506 aa) but shorter 31 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=tcrY;locus_tag=Rv3764c;product=Possible two component sensor kinase TcrY;protein_id=CCP46591.1;transl_table=11
AL123456.3	EMBL	gene	4211080	4211784	.	-	.	ID=gene-Rv3765c;Name=tcrX;gbkey=Gene;gene=tcrX;gene_biotype=protein_coding;locus_tag=Rv3765c
AL123456.3	EMBL	CDS	4211080	4211784	.	-	0	ID=cds-CCP46592.1;Parent=gene-Rv3765c;Dbxref=EnsemblGenomes-Gn:Rv3765c,EnsemblGenomes-Tr:CCP46592,GOA:O69730,InterPro:IPR001789,InterPro:IPR001867,InterPro:IPR011006,InterPro:IPR011991,NCBI_GP:CCP46592.1;Name=CCP46592.1;Note=Rv3765c%2C (MTV025.113c)%2C len: 234 aa. Probable tcrX%2Cresponse regulator of a two-component regulatory system%2Chighly similar to others e.g. Q9ADN7|2SC10A7.24 putative two component system response regulator from Streptomyces coelicolor (271 aa)%2C FASTA scores: opt: 1111%2C E(): 4.8e-63%2C(72.3%25 identity in 231 aa overlap)%3B Q9F161 response regulator from Corynebacterium glutamicum (Brevibacterium flavum) (232 aa)%2C FASTA scores: opt: 692%2C E(): 1.2e-36%2C(46.0%25 identity in 226 aa overlap)%3B Q9KZU5|SCD84.23c putative two-component systen response regulator from Streptomyces coelicolor (248 aa)%2C FASTA scores: opt: 674%2CE(): 1.7e-35%2C (44.05%25 identity in 236 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50806|Rv1033c|MTCY10G2.16 response regulator homolog (257 aa)%2C FASTA scores: opt: 947%2C E(): 1e-52%2C (59.5%25 identity in 232 aa overlap)%3B P71814|Rv0757|MTCY369.02 PHOP-like protein (247 aa) FASTA scores: opt: 829%2C E(): 2.8e-45%2C (54.65%25 identity in 225 aa overlap)%3B O53894|Rv0981|MTV044.09 (230 aa)%2C FASTA scores: opt: 662%2C E(): 9e-35%2C (44.65%25 identity in 224 aa overlap)%3B and also similar to MTCY31_34%3B MTCY19H5_20%3B MTY13628_5%3B MTCY20G9_17%3B and to MLCB57_27 from Mycobacterium leprae%3B and MBY13627_3 from Mycobacterium bovis BCG. Equivalent to AAK48236 from Mycobacterium tuberculosis strain CDC1551 (286 aa) but shorter 52 aa. The N-terminal region is similar to that of other regulatory components of sensory transduction systems. Similar to bacterial regulatory proteins involved in signal transduction.;gbkey=CDS;gene=tcrX;locus_tag=Rv3765c;product=Probable two component transcriptional regulatory protein TcrX;protein_id=CCP46592.1;transl_table=11
AL123456.3	EMBL	gene	4212293	4212982	.	+	.	ID=gene-Rv3766;Name=Rv3766;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3766
AL123456.3	EMBL	CDS	4212293	4212982	.	+	0	ID=cds-CCP46593.1;Parent=gene-Rv3766;Dbxref=EnsemblGenomes-Gn:Rv3766,EnsemblGenomes-Tr:CCP46593,InterPro:IPR017853,UniProtKB/TrEMBL:O69731,NCBI_GP:CCP46593.1;Name=CCP46593.1;Note=Rv3766%2C (MTV025.114)%2C len: 229 aa. Hypothetical unknown protein. Segment 183 to 229 highly similar to C-terminal part of O06288|Rv3594|MTCY07H7B.28c conserved hypothetical protein from Mycobacterium tuberculosis (275 aa)%2C FASTA scores: opt: 128%2C E(): 0.92%2C (46.8%25 identity in 47 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3766;product=Hypothetical protein;protein_id=CCP46593.1;transl_table=11
AL123456.3	EMBL	gene	4212996	4213940	.	-	.	ID=gene-Rv3767c;Name=Rv3767c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3767c
AL123456.3	EMBL	CDS	4212996	4213940	.	-	0	ID=cds-CCP46594.1;Parent=gene-Rv3767c;Dbxref=EnsemblGenomes-Gn:Rv3767c,EnsemblGenomes-Tr:CCP46594,GOA:P9WFH5,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP46594.1;Name=CCP46594.1;Note=Rv3767c%2C (MTV025.115c%2C MTCY13D12.01)%2C len: 314 aa. Possible S-adenosylmethionine-dependent methyltransferase (see Grana et al.%2C 2007)%2C similar to other Mycobacterium tuberculosis hypothetical proteins e.g. P96823|Rv0146|MTCI5.20 34.0 KDA protein (310 aa)%2C FASTA scores: opt: 909%2C E(): 5.3e-50%2C (48.1%25 identity in 316 aa overlap)%3B O53686|Rv0281|MTV035.09 (302 aa)%2C FASTA scores: opt: 802%2C E(): 2.8e-43%2C (45.2%25 identity in 314 aa overlap)%3B Q50726|YX99_MYCTU|Rv3399|MT3507|MTCY78.29c (348 aa)%2C FASTA scores: opt: 796%2C E(): 7.6e-43%2C (45.35%25 identity in 302 aa overlap)%3B MTCY78_30%3B MTCY31_23%3B MTCY210_45%3B MTCY4C12_14%3B MTY13D12_21%2C MTCI5_19%3B MTCY180_22%3B etc. Contains probable N-terminal signal sequence;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3767c;product=Possible S-adenosylmethionine-dependent methyltransferase;protein_id=CCP46594.1;transl_table=11
AL123456.3	EMBL	gene	4214070	4214429	.	+	.	ID=gene-Rv3768;Name=Rv3768;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3768
AL123456.3	EMBL	CDS	4214070	4214429	.	+	0	ID=cds-CCP46595.1;Parent=gene-Rv3768;Dbxref=EnsemblGenomes-Gn:Rv3768,EnsemblGenomes-Tr:CCP46595,InterPro:IPR009959,UniProtKB/TrEMBL:P72035,NCBI_GP:CCP46595.1;Name=CCP46595.1;Note=Rv3768%2C (MTCY13D12.02)%2C len: 119 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3768;product=Unknown protein;protein_id=CCP46595.1;transl_table=11
AL123456.3	EMBL	gene	4214615	4214887	.	+	.	ID=gene-Rv3769;Name=Rv3769;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3769
AL123456.3	EMBL	CDS	4214615	4214887	.	+	0	ID=cds-CCP46596.1;Parent=gene-Rv3769;Dbxref=EnsemblGenomes-Gn:Rv3769,EnsemblGenomes-Tr:CCP46596,UniProtKB/TrEMBL:P72036,NCBI_GP:CCP46596.1;Name=CCP46596.1;Note=Rv3769%2C (MTCY13D12.03)%2C len: 90 aa. Hypothetical unknown protein%2C possible coiled-coil protein.;gbkey=CDS;locus_tag=Rv3769;product=Hypothetical protein;protein_id=CCP46596.1;transl_table=11
AL123456.3	EMBL	gene	4215200	4215775	.	-	.	ID=gene-Rv3770c;Name=Rv3770c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3770c
AL123456.3	EMBL	CDS	4215200	4215775	.	-	0	ID=cds-CCP46597.1;Parent=gene-Rv3770c;Dbxref=EnsemblGenomes-Gn:Rv3770c,EnsemblGenomes-Tr:CCP46597,UniProtKB/TrEMBL:P72037,NCBI_GP:CCP46597.1;Name=CCP46597.1;Note=Rv3770c%2C (MTCY13D12.04c)%2C len: 191 aa. Hypothetical unknown leu-rich protein.;gbkey=CDS;locus_tag=Rv3770c;product=Hypothetical leucine rich protein;protein_id=CCP46597.1;transl_table=11
AL123456.3	EMBL	gene	4215881	4216063	.	-	.	ID=gene-Rv3770A;Name=Rv3770A;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3770A
AL123456.3	EMBL	CDS	4215881	4216063	.	-	0	ID=cds-CCP46598.1;Parent=gene-Rv3770A;Dbxref=EnsemblGenomes-Gn:Rv3770A,EnsemblGenomes-Tr:CCP46598,UniProtKB/TrEMBL:L7N6A0,NCBI_GP:CCP46598.1;Name=CCP46598.1;Note=Rv3770A%2C len: 60 aa. Probable remnant of a transposase%2C similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa)%2C FASTA scores: opt: 204%2C E(): 1e-07%2C (80.5%25 identity in 41 aa overlap). Continuation of Rv3770B.;gbkey=CDS;locus_tag=Rv3770A;product=Probable remnant of a transposase;protein_id=CCP46598.1;transl_table=11
AL123456.3	EMBL	gene	4216078	4216269	.	-	.	ID=gene-Rv3770B;Name=Rv3770B;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3770B
AL123456.3	EMBL	CDS	4216078	4216269	.	-	0	ID=cds-CCP46599.1;Parent=gene-Rv3770B;Dbxref=EnsemblGenomes-Gn:Rv3770B,EnsemblGenomes-Tr:CCP46599,UniProtKB/TrEMBL:L7N679,NCBI_GP:CCP46599.1;Name=CCP46599.1;Note=Rv3770B%2C len: 63 aa. Probable remnant of a transposase%2C similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa)%2C FASTA scores: opt: 379%2C E(): 1.6e-21%2C (93.55%25 identity in 62 aa overlap). Continues as Rv3770A.;gbkey=CDS;locus_tag=Rv3770B;product=Probable remnant of a transposase;protein_id=CCP46599.1;transl_table=11
AL123456.3	EMBL	gene	4216404	4216730	.	-	.	ID=gene-Rv3771c;Name=Rv3771c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3771c
AL123456.3	EMBL	CDS	4216404	4216730	.	-	0	ID=cds-CCP46600.1;Parent=gene-Rv3771c;Dbxref=EnsemblGenomes-Gn:Rv3771c,EnsemblGenomes-Tr:CCP46600,UniProtKB/TrEMBL:P72038,NCBI_GP:CCP46600.1;Name=CCP46600.1;Note=Rv3771c%2C (MTCY13D12.05c)%2C len: 108 aa. Hypothetical protein%2C highly similar%2C but shorter 81 aa%2C to P71640|Rv2811|MTCY16B7.32c hypothetical 21.1 KDA protein from Mycobacterium tuberculosis (202 aa)%2C FASTA scores: opt: 469%2C E(): 2.7e-25%2C (73.15%25 identity in 108 aa overlap);gbkey=CDS;locus_tag=Rv3771c;product=Conserved hypothetical protein;protein_id=CCP46600.1;transl_table=11
AL123456.3	EMBL	gene	4216865	4216937	.	-	.	ID=gene-argU;Name=argU;gbkey=Gene;gene=argU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	4216865	4216937	.	-	.	ID=rna-argU;Parent=gene-argU;Note=codon recognized: CGU%3B argU%2C tRNA-Arg%2C anticodon acg%2C length %3D 73;anticodon=(pos:complement(4216902..4216904));gbkey=tRNA;gene=argU;product=tRNA-Arg
AL123456.3	EMBL	exon	4216865	4216937	.	-	.	ID=exon-argU-1;Parent=rna-argU;Note=codon recognized: CGU%3B argU%2C tRNA-Arg%2C anticodon acg%2C length %3D 73;anticodon=(pos:complement(4216902..4216904));gbkey=tRNA;gene=argU;product=tRNA-Arg
AL123456.3	EMBL	gene	4216968	4217056	.	-	.	ID=gene-serT;Name=serT;gbkey=Gene;gene=serT;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	4216968	4217056	.	-	.	ID=rna-serT;Parent=gene-serT;Note=codon recognized: AGC%3B serT%2C tRNA-Ser%2C anticodon gct%2C length %3D 89;anticodon=(pos:complement(4217020..4217022));gbkey=tRNA;gene=serT;product=tRNA-Ser
AL123456.3	EMBL	exon	4216968	4217056	.	-	.	ID=exon-serT-1;Parent=rna-serT;Note=codon recognized: AGC%3B serT%2C tRNA-Ser%2C anticodon gct%2C length %3D 89;anticodon=(pos:complement(4217020..4217022));gbkey=tRNA;gene=serT;product=tRNA-Ser
AL123456.3	EMBL	gene	4217134	4218195	.	+	.	ID=gene-Rv3772;Name=hisC2;gbkey=Gene;gene=hisC2;gene_biotype=protein_coding;locus_tag=Rv3772
AL123456.3	EMBL	CDS	4217134	4218195	.	+	0	ID=cds-CCP46601.1;Parent=gene-Rv3772;Dbxref=EnsemblGenomes-Gn:Rv3772,EnsemblGenomes-Tr:CCP46601,GOA:P9WML5,InterPro:IPR001917,InterPro:IPR004839,InterPro:IPR005861,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,InterPro:IPR024892,NCBI_GP:CCP46601.1;Name=CCP46601.1;Note=Rv3772%2C (MTCY13D12.06)%2C len: 353 aa. Probable hisC2%2Chistidinol-phosphate aminotransferase%2C highly similar to Q9ZBY8|SCD78.11 putative histidinol-phophate aminotransferase from Streptomyces coelicolor (359 aa)%2CFASTA scores: opt: 1165%2C E(): 7.1e-64%2C (52.55%25 identity in 356 aa overlap)%3B and similar to many e.g. Q9EYX2 from Gardnerella vaginalis (317 aa) FASTA scores: opt: 814%2C E(): 1.7e-42%2C (45.15%25 identity in 308 aa overlap)%3B Q9CMI7|HISH_1PM0838|HISH from Pasteurella multocida (365 aa)%2C FASTA scores: opt: 701%2C E(): 1.5e-35%2C (35.05%25 identity in 351 aa overlap)%3B O07131|HIS8_METFL|HISC|HISH from Methylobacillus flagellatum (368 aa)%2C FASTA scores: opt: 645%2C E(): 4e-32%2C (34.5%25 identity in 345 aa overlap)%3B etc. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. Belongs to class-II of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hisC2;inference=protein motif:PROSITE:PS00599;locus_tag=Rv3772;product=Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase);protein_id=CCP46601.1;transl_table=11
AL123456.3	EMBL	gene	4218241	4218825	.	-	.	ID=gene-Rv3773c;Name=Rv3773c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3773c
AL123456.3	EMBL	CDS	4218241	4218825	.	-	0	ID=cds-CCP46602.1;Parent=gene-Rv3773c;Dbxref=EnsemblGenomes-Gn:Rv3773c,EnsemblGenomes-Tr:CCP46602,GOA:P72040,InterPro:IPR017517,InterPro:IPR017520,UniProtKB/TrEMBL:P72040,NCBI_GP:CCP46602.1;Name=CCP46602.1;Note=Rv3773c%2C (MTCY13D12.07c)%2C len: 194 aa. Conserved protein%2C highly similar to C-terminal end of O53773|Rv0576|MTV039.14 possible transcriptional regulator from Mycobacterium tuberculosis (434 aa)%2C FASTA scores: opt: 575%2C E(): 8.3e-30%2C (47.4%25 identity in 192 aa overlap)%3B and some similarity with other proteins from Mycobacterium tuberculosis e.g. P71985|Rv1727|MTCY04C12.12 (189 aa) FASTA scores: opt: 176%2C E(): 0.00022%2C (31.1%25 identity in 180 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3773c;product=Conserved protein;protein_id=CCP46602.1;transl_table=11
AL123456.3	EMBL	gene	4218849	4219673	.	+	.	ID=gene-Rv3774;Name=echA21;gbkey=Gene;gene=echA21;gene_biotype=protein_coding;locus_tag=Rv3774
AL123456.3	EMBL	CDS	4218849	4219673	.	+	0	ID=cds-CCP46603.1;Parent=gene-Rv3774;Dbxref=EnsemblGenomes-Gn:Rv3774,EnsemblGenomes-Tr:CCP46603,GOA:P75019,InterPro:IPR001753,InterPro:IPR014748,InterPro:IPR029045,UniProtKB/TrEMBL:P75019,NCBI_GP:CCP46603.1;Name=CCP46603.1;Note=Rv3774%2C (MTCY13D12.08)%2C len: 274 aa. Possible echA21%2C enoyl-CoA hydratase%2C equivalent to Q9CD94|ECHA1|ML0120 putative enoyl-CoA hydratase from Mycobacterium leprae (278 aa)%2C FASTA scores: opt: 1593%2CE(): 2.2e-92%2C (88.3%25 identity in 274 aa overlap). Also similar to others e.g. Q9I2S4|PA1821 from Pseudomonas aeruginosa (270 aa)%2C FASTA scores: opt: 761%2C E(): 2e-40%2C(42.3%25 identity in 267 aa overlap)%3B Q9FHR8 from Arabidopsis thaliana (Mouse-ear cress) (278 aa) FASTA scores: opt: 638%2CE(): 9.9e-33%2C (39.4%25 identity in 269 aa overlap)%3B Q9AB78|CC0353 from Caulobacter crescentus (286 aa)%2C FASTA scores: opt: 601%2C E(): 2.1e-31%2C (39.25%25 identity in 266 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=echA21;locus_tag=Rv3774;product=Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);protein_id=CCP46603.1;transl_table=11
AL123456.3	EMBL	gene	4219685	4220932	.	+	.	ID=gene-Rv3775;Name=lipE;gbkey=Gene;gene=lipE;gene_biotype=protein_coding;locus_tag=Rv3775
AL123456.3	EMBL	CDS	4219685	4220932	.	+	0	ID=cds-CCP46604.1;Parent=gene-Rv3775;Dbxref=EnsemblGenomes-Gn:Rv3775,EnsemblGenomes-Tr:CCP46604,GOA:P72041,InterPro:IPR001466,InterPro:IPR012338,UniProtKB/TrEMBL:P72041,NCBI_GP:CCP46604.1;Name=CCP46604.1;Note=Rv3775%2C (MTCY13D12.09)%2C len: 415 aa. Probable lipE%2Chydrolase lipase%2C equivalent to Q9CD95|LIPE|ML0119 probable hydrolase from Mycobacterium leprae (411 aa)%2C FASTA scores: opt: 2418%2C E(): 6.4e-144%2C (84.75%25 identity in 406 aa overlap). Also similar to other esterases e.g. Q9ABH2|CC0255 esterase a from Caulobacter crescentus (374 aa)%2C FASTA scores: opt: 427%2C E(): 2.4e-19%2C (28.9%25 identity in 391 aa overlap)%3B O87861|ESTA esterase a from Streptomyces chrysomallus (389 aa)%2C FASTA scores: opt: 417%2CE(): 1e-18%2C (31.0%25 identity in 361 aa overlap)%3B Q9RK50|SCF12.08 putative esterase from Streptomyces coelicolor (376 aa)%2C FASTA scores: opt: 385%2C E(): 1e-16%2C(31.35%25 identity in 373 aa overlap)%3B etc. Also similar to proteins from Mycobacterium tuberculosis e.g. P71778|Rv1497|MTCY277.19 hypothetical 45.8 KDA protein (429 aa)%2C FASTA scores: opt: 457%2C E(): 3.5e-21%2C (30.4%25 identity in 395 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=lipE;locus_tag=Rv3775;product=Probable lipase LipE;protein_id=CCP46604.1;transl_table=11
AL123456.3	EMBL	gene	4221089	4222648	.	+	.	ID=gene-Rv3776;Name=Rv3776;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3776
AL123456.3	EMBL	CDS	4221089	4222648	.	+	0	ID=cds-CCP46605.1;Parent=gene-Rv3776;Dbxref=EnsemblGenomes-Gn:Rv3776,EnsemblGenomes-Tr:CCP46605,GOA:P72042,InterPro:IPR003615,InterPro:IPR003870,NCBI_GP:CCP46605.1;Name=CCP46605.1;Note=Rv3776%2C (MTCY13D12.10)%2C len: 519 aa. Conserved hypothetical protein%2C highly similar to Q10709|YL00_MYCTU|Rv2100|MTCY49.40 hypothetical 58.9 KDA protein from Mycobacterium tuberculosis (550 aa) FASTA scores: opt: 1646%2C E(): 1.2e-83%2C (77.85%25 identity in 510 aa overlap) (homology from potential start at 7744)%3B and similar to other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O33266|Rv0336|MTCY279.03 (503 aa) FASTA scores: opt: 682%2C E(): 2.2e-30%2C (41.65%25 identity in 497 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3776;product=Conserved hypothetical protein;protein_id=CCP46605.1;transl_table=11
AL123456.3	EMBL	gene	4222581	4222667	.	-	.	ID=gene-serU;Name=serU;gbkey=Gene;gene=serU;gene_biotype=tRNA
AL123456.3	EMBL	tRNA	4222581	4222667	.	-	.	ID=rna-serU;Parent=gene-serU;Note=codon recognized: UCA%3B serU%2C tRNA-Ser%2C anticodon tga%2C length %3D 87;anticodon=(pos:complement(4222631..4222633));gbkey=tRNA;gene=serU;product=tRNA-Ser
AL123456.3	EMBL	exon	4222581	4222667	.	-	.	ID=exon-serU-1;Parent=rna-serU;Note=codon recognized: UCA%3B serU%2C tRNA-Ser%2C anticodon tga%2C length %3D 87;anticodon=(pos:complement(4222631..4222633));gbkey=tRNA;gene=serU;product=tRNA-Ser
AL123456.3	EMBL	gene	4222694	4223680	.	+	.	ID=gene-Rv3777;Name=Rv3777;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3777
AL123456.3	EMBL	CDS	4222694	4223680	.	+	0	ID=cds-CCP46606.1;Parent=gene-Rv3777;Dbxref=EnsemblGenomes-Gn:Rv3777,EnsemblGenomes-Tr:CCP46606,GOA:P72043,InterPro:IPR002085,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR014189,InterPro:IPR016040,UniProtKB/TrEMBL:P72043,NCBI_GP:CCP46606.1;Name=CCP46606.1;Note=Rv3777%2C (MTCY13D12.11)%2C len: 328 aa. Probable oxidoreductase%2C equivalent to Q9CD96|ML0118 putative oxidoreductase from Mycobacterium leprae (336 aa) FASTA scores: opt: 1661%2C E(): 1.1e-87%2C (76.0%25 identity in 325 aa overlap). Also highly similar to many e.g. Q9XA55|SCGD3.24c putative quinone oxidoreductase from Streptomyces coelicolor (326 aa) FASTA scores: opt: 1118%2C E(): 1.3e-64%2C(59.6%25 identity in 312 aa overlap)%3B O65423|F18E5.200|F17L22.40|AT4G21580 putative NADPH quinone oxidoreductase from Arabidopsis thaliana (Mouse-ear cress) (325 aa)%2C FASTA scores: opt: 1110%2C E(): 3e-56%2C (52.15%25 identity in 326 aa overlap)%3B Q98FI0|MLL3767 NADPH quinone oxidoreductase from Rhizobium loti (Mesorhizobium loti) (326 aa)%2C FASTA scores: opt: 980%2C E(): 7.9e-49%2C (47.85%25 identity in 324 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3777;product=Probable oxidoreductase;protein_id=CCP46606.1;transl_table=11
AL123456.3	EMBL	gene	4223699	4224895	.	-	.	ID=gene-Rv3778c;Name=Rv3778c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3778c
AL123456.3	EMBL	CDS	4223699	4224895	.	-	0	ID=cds-CCP46607.1;Parent=gene-Rv3778c;Dbxref=EnsemblGenomes-Gn:Rv3778c,EnsemblGenomes-Tr:CCP46607,GOA:P9WQ67,InterPro:IPR000192,InterPro:IPR011340,InterPro:IPR015421,InterPro:IPR015422,InterPro:IPR015424,PDB:3CAI,NCBI_GP:CCP46607.1;Name=CCP46607.1;Note=Rv3778c%2C (MTCY13D12.12c)%2C len: 398 aa. Possible aminotransferase%2C equivalent to Q9CD97|ML0117 hypothetical protein from Mycobacterium leprae (398 aa) FASTA scores: opt: 2141%2C E(): 1.2e-123%2C (83.4%25 identity in 398 aa overlap). Also similar to other aminotransferases and cysteine desulfurases e.g. Q9K3K6|SCG20A.34 putative aminotransferase from Streptomyces coelicolor (400 aa)%2CFASTA scores: opt: 723%2C E(): 6.5e-37%2C (36.3%25 identity in 402 aa overlap)%3B Q9KSS2|VC1184 NIFS-related protein (aminotransferase-related) from Vibrio cholerae (416 aa) FASTA scores: opt: 595%2C E(): 4.5e-29%2C (31.35%25 identity in 405 aa overlap)%3B Q98NK4|MLR0102 aminotransferase from Rhizobium loti (Mesorhizobium loti) (425 aa)%2C FASTA scores: opt: 563%2C E(): 4.2e-27%2C (29.4%25 identity in 408 aa overlap)%3B Q9RY03|DR0151 NIFS-related protein from Deinococcus radiodurans (401 aa)%2C FASTA scores: opt: 484%2C E(): 2.7e-22%2C(32.35%25 identity in 399 aa overlap)%3B Q9A766|CC1860 aminotransferase class V from Caulobacter crescentus (408 aa)%2C FASTA scores: opt: 390%2C E(): 1.5e-16%2C (27.85%25 identity in 413 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3778c;product=Possible aminotransferase;protein_id=CCP46607.1;transl_table=11
AL123456.3	EMBL	gene	4224985	4226985	.	+	.	ID=gene-Rv3779;Name=Rv3779;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3779
AL123456.3	EMBL	CDS	4224985	4226985	.	+	0	ID=cds-CCP46608.1;Parent=gene-Rv3779;Dbxref=EnsemblGenomes-Gn:Rv3779,EnsemblGenomes-Tr:CCP46608,GOA:P72045,UniProtKB/TrEMBL:P72045,NCBI_GP:CCP46608.1;Name=CCP46608.1;Note=Rv3779%2C (MTCY13D12.13)%2C len: 666 aa. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Probable conserved transmembrane ala-%2C leu-rich protein%2C equivalent to Q9CD98|ML0116 putative membrane protein from Mycobacterium leprae (654 aa)%2C FASTA scores: opt: 1991%2C E(): 2e-112%2C (66.5%25 identity in 666 aa overlap). Shows some similarity with Q9RRU0|DR2395 putative NA+/H+ antiporter from Deinococcus radiodurans (458 aa)%2C FASTA scores: opt: 138%2C E(): 0.69%2C(31.9%25 identity in 138 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3779;product=Probable conserved transmembrane protein alanine and leucine rich;protein_id=CCP46608.1;transl_table=11
AL123456.3	EMBL	gene	4226989	4227525	.	+	.	ID=gene-Rv3780;Name=Rv3780;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3780
AL123456.3	EMBL	CDS	4226989	4227525	.	+	0	ID=cds-CCP46609.1;Parent=gene-Rv3780;Dbxref=EnsemblGenomes-Gn:Rv3780,EnsemblGenomes-Tr:CCP46609,GOA:P9WKX3,InterPro:IPR019695,NCBI_GP:CCP46609.1;Name=CCP46609.1;Note=Rv3780%2C (MTCY13D12.14)%2C len: 178 aa. Conserved protein%2C equivalent to Q9CD99|ML0115 hypothetical 19.1 KDA protein from Mycobacterium leprae (174 aa)%2C FASTA scores: opt: 903%2C E(): 2.3e-48%2C (82.95%25 identity in 170 aa overlap). Also highly similar to Q9XA56|SCGD3.23c hypothetical 19.5 KDA protein from Streptomyces coelicolor (179 aa)%2C FASTA scores: opt: 692%2C E(): 1.8e-35%2C (65.9%25 identity in 170 aa overlap). Note that this putative protein is 4 aa longer at the N-terminus compared to previous annotation (in Nature 393: 537-544 (1998)).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3780;product=Conserved protein;protein_id=CCP46609.1;transl_table=11
AL123456.3	EMBL	gene	4227529	4228350	.	+	.	ID=gene-Rv3781;Name=rfbE;gbkey=Gene;gene=rfbE;gene_biotype=protein_coding;locus_tag=Rv3781
AL123456.3	EMBL	CDS	4227529	4228350	.	+	0	ID=cds-CCP46610.1;Parent=gene-Rv3781;Dbxref=EnsemblGenomes-Gn:Rv3781,EnsemblGenomes-Tr:CCP46610,GOA:P72047,InterPro:IPR003439,InterPro:IPR003593,InterPro:IPR027417,UniProtKB/TrEMBL:P72047,NCBI_GP:CCP46610.1;Name=CCP46610.1;Note=Rv3781%2C (MTCY13D12.15)%2C len: 273 aa. Probable rfbE%2Cpolysaccharide-transport ATP-binding protein ABC transporter%2C involved in O-antigen/lipopolysaccharides (LPS) transport (see Braibant et al.%2C 2000)%2C equivalent to Q9CDA0|ML0114 putative ABC transporter ATP-binding component from Mycobacterium leprae (272 aa)%2C FASTA scores: opt: 1581%2C E(): 3e-83%2C (91.4%25 identity in 267 aa overlap). Also highly similar to AAK71283 LPS/O-antigen export permease from Coxiella burnetii (258 aa)%2C FASTA scores: opt: 793%2C E(): 2.5e-38%2C (45.45%25 identity in 253 aa overlap)%3B Q9PAF0|XF2568 ABC transporter ATP-binding protein from Xylella fastidiosa (246 aa)%2C FASTA scores: opt: 758%2CE(): 2.4e-36%2C (47.75%25 identity in 243 aa overlap)%3B Q56903|RFBE_YEREN O-antigen export system ATP-binding protein from Yersinia enterocolitica (239 aa) (see Zhang et al.%2C 1993)%2C FASTA scores: opt: 697%2C E(): 7e-33%2C (48.65%25 identity in 224 aa overlap)%3B Q50863|RFBB_MYXXA O-antigen export system ATP-binding from Myxococcus xanthus (437 aa)%2CFASTA scores: opt: 605%2C E(): 2e-27%2C (42.05%25 identity in 207 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC transporters).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rfbE;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3781;product=Probable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE;protein_id=CCP46610.1;transl_table=11
AL123456.3	EMBL	gene	4228347	4229261	.	+	.	ID=gene-Rv3782;Name=glfT1;gbkey=Gene;gene=glfT1;gene_biotype=protein_coding;gene_synonym=rfbE;locus_tag=Rv3782
AL123456.3	EMBL	CDS	4228347	4229261	.	+	0	ID=cds-CCP46611.1;Parent=gene-Rv3782;Dbxref=EnsemblGenomes-Gn:Rv3782,EnsemblGenomes-Tr:CCP46611,GOA:P9WMX3,InterPro:IPR029044,NCBI_GP:CCP46611.1;Name=CCP46611.1;Note=Rv3782%2C (MTCY13D12.16)%2C len: 304 aa. GlfT1%2CUDP-galactofuranosyl transferase (See Mikusova et al.%2C2006%3B Belanova et al.%2C 2008)%2C equivalent to Q9CDA1|RFBE|ML0113 putative glycosyl transferase from Mycobacterium leprae (283 aa)%2C FASTA scores: opt: 1583%2CE(): 9.3e-96%2C (81.6%25 identity in 277 aa overlap). Also some similarity with AAK68916|WCFN putative glycosyltransferase from Bacteroides fragilis (291 aa) FASTA scores: opt: 241%2CE(): 2.1e-08%2C (30.75%25 identity in 195 aa overlap)%3B O58161|PH0424 hypothetical 40.5 KDA protein from Pyrococcus horikoshii (348 aa)%2C FASTA scores: opt: 194%2C E(): 2.8e-05%2C(23.85%25 identity in 302 aa overlap)%3B O26448|MTH348 rhamnosyl transferase from Methanothermobacter thermautotrophicus (313 aa)%2C FASTA scores: opt: 177%2C E(): 0.00033%2C (28.2%25 identity in 333 aa overlap)%3B O07868|CPS19BQ putative rhamnosyl transferase FASTA from Streptococcus pneumoniae (300 aa)%2C FASTA scores: opt: 156%2C E(): 0.0074%2C(25.45%25 identity in 232 aa overlap)%3B and other putative transferases. Note that C-terminal end shows some similarity with part of Q05161|RFB O-antigen biosynthesis protein B from Escherichia coli strain 0101. Note that previously known as rfbE.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glfT1;locus_tag=Rv3782;product=UDP-galactofuranosyl transferase GlfT1;protein_id=CCP46611.1;transl_table=11
AL123456.3	EMBL	gene	4229258	4230100	.	+	.	ID=gene-Rv3783;Name=rfbD;gbkey=Gene;gene=rfbD;gene_biotype=protein_coding;locus_tag=Rv3783
AL123456.3	EMBL	CDS	4229258	4230100	.	+	0	ID=cds-CCP46612.1;Parent=gene-Rv3783;Dbxref=EnsemblGenomes-Gn:Rv3783,EnsemblGenomes-Tr:CCP46612,GOA:P72049,InterPro:IPR013525,UniProtKB/TrEMBL:P72049,NCBI_GP:CCP46612.1;Name=CCP46612.1;Note=Rv3783%2C (MTCY13D12.17)%2C len: 280 aa. Probable rfbD%2Cpolysaccharide-transport integral membrane protein ABC transporter (see Braibant et al.%2C 2000)%2C involved in O-antigen/lipopolysaccharides (LPS) transport%2C equivalent to Q9CDA2|ML0112 putative ABC transporter component from Mycobacterium leprae (276 aa)%2C FASTA scores: opt: 1646%2CE(): 4e-102%2C (84.3%25 identity in 280 aa overlap). Also highly similar to Q9PAF1|XF2567 ABC transporter permease protein from Xylella fastidiosa (267 aa)%2C FASTA scores: opt: 723%2C E(): 7.6e-41%2C (41.3%25 identity in 259 aa overlap)%3B and similar to others e.g. Q56902|RFBD_YEREN O-antigen export system permease protein from Yersinia enterocolitica (259 aa) (see Zhang et al.%2C 1993)%2C FASTA scores: opt: 566%2CE(): 2e-30%2C (28.05%25 identity in 264 aa overlap)%3B Q06955|RFBH RFBH protein (involved in the export of lipopolysaccharide) (alias Q9KVA3|VC0246) lipopolysaccharide/O-antigen transport protein from Vibrio cholerae (257 aa)%2C FASTA scores: opt: 358%2C E(): 1.3e-16%2C(24.4%25 identity in 258 aa overlap)%3B Q9HTB8|WZM|PA5451 membrane subunit of a-band LPS efflux transporter from Pseudomonas aeruginosa (265 aa)%2C FASTA scores: opt: 263%2CE(): 2.7e-10%2C (25.45%25 identity in 263 aa overlap)%3B etc. Belongs to the ABC-2 subfamily of integral membrane proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rfbD;locus_tag=Rv3783;product=Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD;protein_id=CCP46612.1;transl_table=11
AL123456.3	EMBL	gene	4230256	4231236	.	+	.	ID=gene-Rv3784;Name=Rv3784;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3784
AL123456.3	EMBL	CDS	4230256	4231236	.	+	0	ID=cds-CCP46613.1;Parent=gene-Rv3784;Dbxref=EnsemblGenomes-Gn:Rv3784,EnsemblGenomes-Tr:CCP46613,GOA:P72050,InterPro:IPR001509,InterPro:IPR016040,UniProtKB/TrEMBL:P72050,NCBI_GP:CCP46613.1;Name=CCP46613.1;Note=Rv3784%2C (MTCY13D12.18)%2C len: 326 aa. Possible dTDP-glucose 4%2C6-dehydratase%2C but experimental study shown that the purified protein didn't have dTDP-glucose dehydratase (rmlB) activity (see citation below). Similar to others e.g. Q9YCT1|APE1180 long hypothetical dTDP-glucose 4%2C6-dehydratase from Aeropyrum pernix (330 aa) FASTA scores: opt: 598%2C E(): 3.7e-30%2C (34.9%25 identity in 315 aa overlap)%3B O27817|MTH1789 dTDP-glucose 4%2C6-dehydratase from Methanothermobacter thermautotrophicus (336 aa) FASTA scores: opt: 587%2C E(): 1.8e-29%2C (34.9%25 identity in 315 aa overlap)%3B Q9X5W0|GRSE TDP-glucose-4%2C6-dehydratase homolog from Streptomyces griseus (324 aa)%2C FASTA scores: opt: 583%2C E(): 3.2e-29%2C(35.7%25 identity in 325 aa overlap)%3B Q9K7J7|SPSJ|BH3364 spore coat polysaccharide synthesis (dTDP glucose 4%2C6-dehydratase) from Bacillus halodurans (321 aa)%2C FASTA scores: opt: 562%2C E(): 6.5e-28%2C (33.0%25 identity in 318 aa overlap)%3B Q9UZH2|RFBB|PAB0785 dTDP-glucose 4%2C6-dehydratase from Pyrococcus abyssi (333 aa)%2C FASTA scores: opt: 552%2CE(): 2.8e-27%2C (33.95%25 identity in 318 aa overlap)%3B P27830|RFFG_ECOLI|B3788 dTDP-glucose 4%2C6-dehydratase from Escherichia coli strain K12 (355 aa)%2C FASTA scores: opt: 401%2C E(): 7.5e-28%2C (31.3%25 identity in 348 aa overlap)%3B etc. But also similar to several UDP-glucose 4-epimerases and other proteins e.g. O59375|PH1742 long hypothetical UDP-glucose 4-epimerase from Pyrococcus horikoshii (306 aa) FASTA scores: opt: 600%2C E(): 2.6e-30%2C (34.5%25 identity in 313 aa overlap)%3B Q9ZGC7|LANH14 NDP-hexose 4%2C6-dehydratase HOMOLOGfrom Streptomyces cyanogenus (326 aa)%2C FASTA scores: opt: 593%2C E(): 7.6e-30%2C (36.45%25 identity in 321 aa overlap)%3B Q57664|GALE_METJA|MJ0211 putative UDP-glucose 4-epimerase from Methanococcus jannaschii (305 aa) FASTA scores: opt: 575%2C E(): 9.6e-29%2C (32.6%25 identity in 313 aa overlap)%3B etc. Seems to belong to the sugar epimerase family%2C dTDP-glucose dehydratase subfamily. Note that previously known as epiB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3784;product=Possible dTDP-glucose 4%2C6-dehydratase;protein_id=CCP46613.1;transl_table=11
AL123456.3	EMBL	gene	4231320	4232393	.	+	.	ID=gene-Rv3785;Name=Rv3785;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3785
AL123456.3	EMBL	CDS	4231320	4232393	.	+	0	ID=cds-CCP46614.1;Parent=gene-Rv3785;Dbxref=EnsemblGenomes-Gn:Rv3785,EnsemblGenomes-Tr:CCP46614,GOA:P9WKX1,NCBI_GP:CCP46614.1;Name=CCP46614.1;Note=Rv3785%2C (MTCY13D12.19)%2C len: 357 aa. Hypothetical unknown protein. Note that this putative protein is equivalent to AAK48258|MT3893 NAD-dependent epimerase/dehydratase family protein from Mycobacterium tuberculosis strain CDC1551 (712 aa)%2C but shorter 355 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3785;product=Hypothetical protein;protein_id=CCP46614.1;transl_table=11
AL123456.3	EMBL	gene	4232374	4233597	.	-	.	ID=gene-Rv3786c;Name=Rv3786c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3786c
AL123456.3	EMBL	CDS	4232374	4233597	.	-	0	ID=cds-CCP46615.1;Parent=gene-Rv3786c;Dbxref=EnsemblGenomes-Gn:Rv3786c,EnsemblGenomes-Tr:CCP46615,GOA:P9WKW9,InterPro:IPR011055,InterPro:IPR016047,InterPro:IPR029044,NCBI_GP:CCP46615.1;Name=CCP46615.1;Note=Rv3786c%2C (MTCY13D12.20)%2C len: 407 aa. Unknown protein. Segment between aa 265-300 (approximately) is highly similar to part of O03937|RORF1608 minor capsid protein from Bacteriophage phig1e (1608 aa)%2C FASTA scores: opt: 242%2C E(): 8.4e-07%2C (26.85%25 identity in 272 aa overlap)%3B Q9ETT9|ORF36 putative peptidase from Corynebacterium equii (Rhodococcus equi) plasmid pREAT701 (p33701) and Plasmid virulence (546 aa)%2C FASTA scores: opt: 231%2C E(): 1.6e-06%2C (34.15%25 identity in 167 aa overlap)%3B O69910|SC2E1.40c hypothetical 22.8 KDA protein. from Streptomyces coelicolor (226 aa) FASTA scores: opt: 218%2CE(): 4.6e-06%2C (34.15%25 identity in 164 aa overlap)%3B and others.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3786c;product=Unknown protein;protein_id=CCP46615.1;transl_table=11
AL123456.3	EMBL	gene	4233610	4234536	.	-	.	ID=gene-Rv3787c;Name=Rv3787c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3787c
AL123456.3	EMBL	CDS	4233610	4234536	.	-	0	ID=cds-CCP46616.1;Parent=gene-Rv3787c;Dbxref=EnsemblGenomes-Gn:Rv3787c,EnsemblGenomes-Tr:CCP46616,GOA:P9WFH3,InterPro:IPR007213,InterPro:IPR011610,InterPro:IPR029063,NCBI_GP:CCP46616.1;Name=CCP46616.1;Note=Rv3787c%2C (MTCY13D12.21)%2C len: 308 aa. Conserved hypothetical protein%2C highly similar to several mycobacterial hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c from Mycobacterium tuberculosis (367 aa)%2C FASTA scores: opt: 1038%2C E(): 1.6e-58%2C (55.85%25 identity in 283 aa overlap)%3B O53795|MBE50c|Rv0731c|MTV041.05c from Mycobacterium tuberculosis (318 aa)%2C FASTA scores: opt: 1030%2C E(): 4.5e-58%2C (56.15%25 identity in 292 aa overlap)%3B Q9CCZ4|ML2640 from Mycobacterium leprae (310 aa) FASTA scores: opt: 709%2CE(): 9.9e-38%2C (43.75%25 identity in 279 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3787c;product=Conserved hypothetical protein;protein_id=CCP46616.1;transl_table=11
AL123456.3	EMBL	gene	4234780	4235265	.	+	.	ID=gene-Rv3788;Name=Rv3788;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3788
AL123456.3	EMBL	CDS	4234780	4235265	.	+	0	ID=cds-CCP46617.1;Parent=gene-Rv3788;Dbxref=EnsemblGenomes-Gn:Rv3788,EnsemblGenomes-Tr:CCP46617,GOA:P9WKW7,InterPro:IPR001437,InterPro:IPR023459,NCBI_GP:CCP46617.1;Name=CCP46617.1;Note=Rv3788%2C (MTCY13D12.22)%2C len: 161 aa. Hypothetical unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3788;product=Hypothetical protein;protein_id=CCP46617.1;transl_table=11
AL123456.3	EMBL	gene	4235374	4235739	.	+	.	ID=gene-Rv3789;Name=Rv3789;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3789
AL123456.3	EMBL	CDS	4235374	4235739	.	+	0	ID=cds-CCP46618.1;Parent=gene-Rv3789;Dbxref=EnsemblGenomes-Gn:Rv3789,EnsemblGenomes-Tr:CCP46618,GOA:P9WMS9,InterPro:IPR007267,NCBI_GP:CCP46618.1;Name=CCP46618.1;Note=Rv3789%2C (MTCY13D12.23)%2C len: 121 aa. GtrA family protein%3B possible integral membrane protein%2C equivalent to Q9CDA3|ML0110 hypothetical 13.9 KDA protein from Mycobacterium leprae (123 aa) FASTA scores: opt: 587%2C E(): 7.3e-34%2C (72.95%25 identity in 122 aa overlap). Also equivalent to AAK48262 from Mycobacterium tuberculosis strain CDC1551 (142 aa) but shorter 21 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3789;product=GTRA family protein;protein_id=CCP46618.1;transl_table=11
AL123456.3	EMBL	gene	4235779	4237164	.	+	.	ID=gene-Rv3790;Name=dprE1;gbkey=Gene;gene=dprE1;gene_biotype=protein_coding;locus_tag=Rv3790
AL123456.3	EMBL	CDS	4235779	4237164	.	+	0	ID=cds-CCP46619.1;Parent=gene-Rv3790;Dbxref=EnsemblGenomes-Gn:Rv3790,EnsemblGenomes-Tr:CCP46619,GOA:P9WJF1,InterPro:IPR006094,InterPro:IPR007173,InterPro:IPR016166,InterPro:IPR016169,PDB:4FDN,PDB:4FDO,PDB:4FDP,PDB:4FEH,PDB:4FF6,PDB:4NCR,NCBI_GP:CCP46619.1;Name=CCP46619.1;Note=Rv3790%2C (MTCY13D12.24)%2C len: 461 aa. DprE1%2Cdecaprenylphosphoryl-beta-D-ribose 2'-oxidase%2C equivalent to Q9CDA4|ML0109 putative FAD-linked oxidoreductase from Mycobacterium leprae (460 aa)%2C FASTA scores: opt: 2722%2CE(): 1.4e-161%2C (86.55%25 identity in 461 aa overlap). Also highly similar to others e.g. Q9KZA4|SC5G8.10c putative oxidoreductase from Streptomyces coelicolor (457 aa)%2C FASTA scores: opt: 1336%2C E(): 1.7e-75%2C (47.1%25 identity in 452 aa overlap)%3B Q98KY4|MLL1265 probable oxidoreductase from Rhizobium loti (Mesorhizobium loti) (449 aa)%2C FASTA scores: opt: 636%2C E(): 4.9e-32%2C (36.0%25 identity in 439 aa overlap)%3B Q9HDX8|SPAPB1A10.12c putative D-arabinono-1%2C4-lactone oxidase from Schizosaccharomyces pombe (Fission yeast) (461 aa)%2C FASTA scores: opt: 297%2C E(): 5.6e-11%2C (23.55%25 identity in 467 aa overlap)%3B etc. C-terminal end has a high similarity to Q9AQD0 putative oxidoreductase (fragment) from Mycobacterium smegmatis (149 aa) FASTA scores: opt: 901%2C E(): 6.5e-49%2C (86.6%25 identity in 149 aa overlap). Identified as the target of antimicrobial agent 1%2C3-benzothiazin-4-ones (BTZs) (See Makarov et al.%2C 2009).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dprE1;locus_tag=Rv3790;product=Decaprenylphosphoryl-beta-D-ribose 2'-oxidase;protein_id=CCP46619.1;transl_table=11
AL123456.3	EMBL	gene	4237165	4237929	.	+	.	ID=gene-Rv3791;Name=dprE2;gbkey=Gene;gene=dprE2;gene_biotype=protein_coding;locus_tag=Rv3791
AL123456.3	EMBL	CDS	4237165	4237929	.	+	0	ID=cds-CCP46620.1;Parent=gene-Rv3791;Dbxref=EnsemblGenomes-Gn:Rv3791,EnsemblGenomes-Tr:CCP46620,GOA:P9WGS9,InterPro:IPR002198,InterPro:IPR002347,InterPro:IPR016040,InterPro:IPR020904,NCBI_GP:CCP46620.1;Name=CCP46620.1;Note=Rv3791%2C (MTCY13D12.25)%2C len: 254 aa. DprE2%2Cdecaprenylphosphoryl-D-2-keto erythro pentose reductase%2Cequivalent to Q9CDA5|ML0108 putative oxidoreductase from Mycobacterium leprae (254 aa)%2C FASTA scores: opt: 1458%2CE(): 1.6e-83%2C (89.0%25 identity in 254 aa overlap)%3B and O05764 putative protein belonging to the short-chain alcohol dehydrogenase from Mycobacterium smegmatis (254 aa)%2C FASTA scores: opt: 1412%2C E(): 1.2e-80%2C (85.05%25 identity in 254 aa overlap). Also highly similar to Q9KZA5|SC5G8.09c putative short-chain dehydrogenase from Streptomyces coelicolor (256 aa)%2C FASTA scores: opt: 733%2CE(): 1.8e-38%2C (45.3%25 identity in 254 aa overlap)%3B and P43168|YMP3_STRCO hypothetical oxidoreductase from Streptomyces coelicolor (251 aa)%2C FASTA scores: opt: 623%2CE(): 1.2e-31%2C (42.15%25 identity in 254 aa overlap)%3B and similar to various oxidoreductases (principally acetoacetyl-CoA reductases) e.g. P14697|PHBB_ALCEU acetoacetyl-CoA reductase (246 aa) from Alcaligenes eutrophus (Ralstonia eutropha) (246 aa) FASTA scores: opt: 264%2C E(): 2.3e-09%2C (29.9%25 identity in 204 aa overlap)%3B P45375|PHBB_CHRVI acetoacetyl-CoA reductase from Chromatium vinosum (246 aa)%2C FASTA scores: opt: 261%2C E(): 3.5e-09%2C(27.45%25 identity in 226 aa overlap)%3B Q9RT30|DR1938 oxidoreductase (short-chain dehydrogenase/reductase family) from Deinococcus radiodurans (283 aa)%2C FASTA scores: opt: 251%2C E(): 1.7e-08%2C (27.55%25 identity in 236 aa overlap)%3B etc. Also similar to Q10681|YK73_MYCTU|Rv2073c|MT2133|MTCY49.12 putative short-chain type dehydrogenase/reductase from Mycobacterium tuberculosis (249 aa)%2C FASTA scores: opt: 589%2C E(): 1.5e-29%2C (41.25%25 identity in 252 aa overlap). Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases (SDR) family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=dprE2;inference=protein motif:PROSITE:PS00061;locus_tag=Rv3791;product=Decaprenylphosphoryl-D-2-keto erythro pentose reductase;protein_id=CCP46620.1;transl_table=11
AL123456.3	EMBL	gene	4237932	4239863	.	+	.	ID=gene-Rv3792;Name=aftA;gbkey=Gene;gene=aftA;gene_biotype=protein_coding;locus_tag=Rv3792
AL123456.3	EMBL	CDS	4237932	4239863	.	+	0	ID=cds-CCP46621.1;Parent=gene-Rv3792;Dbxref=EnsemblGenomes-Gn:Rv3792,EnsemblGenomes-Tr:CCP46621,GOA:P9WN03,InterPro:IPR020959,InterPro:IPR020963,NCBI_GP:CCP46621.1;Name=CCP46621.1;Note=Rv3792%2C (MTCY13D12.26)%2C len: 643 aa. aftA%2Carabinofuranosyltransferase (See Alderwick et al.%2C 2006). Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian%2C 2003). Probable conserved transmembrane protein%2C equivalent%2C but longer 21 aa%2C to Q9CDA6|ML0107 putative membrane protein from Mycobacterium leprae (632 aa)%2C FASTA scores: opt: 1981%2C E(): 2.1e-110%2C (77.5%25 identity in 631 aa overlap). C-terminal end highly similar to C-terminus of O05765 putative product ORF 3 from Mycobacterium smegmatis (603 aa)%2C FASTA scores: opt: 1261%2C E(): 1.4e-67%2C (70.7%25 identity in 266 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=aftA;locus_tag=Rv3792;product=Arabinofuranosyltransferase AftA;protein_id=CCP46621.1;transl_table=11
AL123456.3	EMBL	gene	4239863	4243147	.	+	.	ID=gene-Rv3793;Name=embC;gbkey=Gene;gene=embC;gene_biotype=protein_coding;locus_tag=Rv3793
AL123456.3	EMBL	CDS	4239863	4243147	.	+	0	ID=cds-CCP46622.1;Parent=gene-Rv3793;Dbxref=EnsemblGenomes-Gn:Rv3793,EnsemblGenomes-Tr:CCP46622,GOA:P9WNL5,InterPro:IPR007680,InterPro:IPR027451,PDB:3PTY,NCBI_GP:CCP46622.1;Name=CCP46622.1;Note=Rv3793%2C (MTCY13D12.27)%2C len: 1094 aa. EmbC%2C integral membrane protein%2C indolylacetylinositol arabinosyltransferase (see citations below)%2C equivalent to Q9CDA7|EMBC|ML0106 putative arabinosyl transferase from Mycobacterium leprae (1070 aa) FASTA scores: opt: 6078%2CE(): 0%2C (82.95%25 identity in 1072 aa overlap)%3B Q50393|EMBC putative arabinosyl transferase from Mycobacterium smegmatis (1074 aa)%2C FASTA scores: opt: 5523%2C E(): 0%2C(75.35%25 identity in 1072 aa overlap). Also similar to Q9CDA9|EMBB| ML0104 putative arabinosyl transferase from Mycobacterium leprae (1083 aa)%2C FASTA scores: opt: 2789%2CE(): 1.9e-156%2C (44.0%25 identity in 1095 aa overlap)%3B O30406|EMBB putative arabinosyl transferase from Mycobacterium smegmatis (1082 aa)%2C FASTA scores: opt: 2746%2CE(): 6.4e-154%2C (44.6%25 identity in 1096 aa overlap)%3B etc. Also similar to to P72030|EMBB|Rv3795|MTCY13D12.29 indolylacetylinositol arabinosyltransferase from Mycobacterium tuberculosis (1098 aa)%2C FASTA scores: opt: 2276%2C E(): 3.1e-126%2C (44.45%25 identity in 1118 aa overlap)%3B and P72060|EMBA|Rv3794|MTCY13D12.28 indolylacetylinositol arabinosyltransferase from Mycobacterium tuberculosis (1094 aa)%2C FASTA scores: opt: 1974%2C E(): 1.9e-108%2C (41.0%25 identity in 1110 aa overlap). Contains PS00044 Bacterial regulatory proteins%2C lysR family signature%3B and PS00017 ATP/GTP-binding site motif A (P-loop). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=embC;inference=protein motif:PROSITE:PS00044;locus_tag=Rv3793;product=Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase);protein_id=CCP46622.1;transl_table=11
AL123456.3	EMBL	gene	4243233	4246517	.	+	.	ID=gene-Rv3794;Name=embA;gbkey=Gene;gene=embA;gene_biotype=protein_coding;locus_tag=Rv3794
AL123456.3	EMBL	CDS	4243233	4246517	.	+	0	ID=cds-CCP46623.1;Parent=gene-Rv3794;Dbxref=EnsemblGenomes-Gn:Rv3794,EnsemblGenomes-Tr:CCP46623,GOA:P9WNL9,InterPro:IPR007680,InterPro:IPR027451,NCBI_GP:CCP46623.1;Name=CCP46623.1;Note=Rv3794%2C (MTCY13D12.28)%2C len: 1094 aa. EmbA%2C integral membrane protein%2C indolylacetylinositol arabinosyltransferase (see citations below)%2C equivalent to P71485|EMBA arabinosyl transferase from Mycobacterium avium (1108 aa)%2C FASTA scores: opt: 5024%2C E(): 0%2C (81.9%25 identity in 1109 aa overlap)%3B Q9CDA8|EMBA|ML0105 putative arabinosyl transferase from Mycobacterium leprae (1111 aa)%2C FASTA scores: opt: 4782%2C E(): 0%2C (78.6%25 identity in 1111 aa overlap)%3B Q50394|EMBA putative arabinosyl transferase from Mycobacterium smegmatis (1092 aa)%2C FASTA scores: opt: 4100%2CE(): 0%2C (67.4%25 identity in 1092 aa overlap). Also similar to Q9CDA7|EMBC|ML0106 putative arabinosyl transferase from Mycobacterium leprae (1070 aa)%2C FASTA scores: opt: 1933%2CE(): 1.5e-100%2C (40.6%25 identity in 1108 aa overlap)%3B Q50393|EMBC putative arabinosyl transferase from Mycobacterium smegmatis (1074 aa)%2C FASTA scores: opt: 1870%2CE(): 5.1e-97%2C (41.4%25 identity in 1113 aa overlap)%3B etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 indolylacetylinositol arabinosyltransferase from Mycobacterium tuberculosis (1094 aa)%2C FASTA scores: opt: 1974%2C E(): 7.7e-103%2C (40.9%25 identity in 1110 aa overlap)%3B and P72030|EMBB|Rv3795|MTCY13D12.29 indolylacetylinositol arabinosyltransferase from Mycobacterium tuberculosis (1098 aa)%2C FASTA scores: opt: 1288%2C E(): 2.1e-64%2C (42.5%25 identity in 1114 aa overlap). Supposedly regulated by embR|Rv1267c. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=embA;locus_tag=Rv3794;product=Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase);protein_id=CCP46623.1;transl_table=11
AL123456.3	EMBL	gene	4246514	4249810	.	+	.	ID=gene-Rv3795;Name=embB;gbkey=Gene;gene=embB;gene_biotype=protein_coding;locus_tag=Rv3795
AL123456.3	EMBL	CDS	4246514	4249810	.	+	0	ID=cds-CCP46624.1;Parent=gene-Rv3795;Dbxref=EnsemblGenomes-Gn:Rv3795,EnsemblGenomes-Tr:CCP46624,GOA:P9WNL7,InterPro:IPR007680,InterPro:IPR027451,NCBI_GP:CCP46624.1;Name=CCP46624.1;Note=Rv3795%2C (MTCY13D12.29)%2C len: 1098 aa. EmbB%2C integral membrane protein%2C indolylacetylinositol arabinosyltransferase (see citations below)%2C equivalent to P71486|EMBB arabinosyl transferase from Mycobacterium avium (1065 aa)%2C FASTA scores: opt: 4998%2C E(): 0%2C (83.25%25 identity in 1076 aa overlap)%3B Q9CDA9|EMBB|ML0104 putative arabinosyl transferase from Mycobacterium leprae (1083 aa)%2CFASTA scores: opt: 4706%2C E(): 0%2C (78.0%25 identity in 1101 aa overlap)%3B O30406|EMBB (alias Q50395) putative arabinosyl transferase from Mycobacterium smegmatis (1082 aa)%2C FASTA scores: opt: 4163%2C E(): 0%2C (68.4%25 identity in 1091 aa overlap)%3B etc. Also similar to Q50393|EMBC putative arabinosyl transferase from Mycobacterium smegmatis (1074 aa)%2C FASTA scores: opt: 2482%2C E(): 5e-135%2C (44.7%25 identity in 1101 aa overlap)%3B Q9CDA7|EMBC|ML0106 putative arabinosyl transferase from Mycobacterium leprae (1070 aa)%2C FASTA scores: opt: 2259%2C E(): 3.4e-122%2C (43.4%25 identity in 1104 aa overlap)%3B etc. Also similar to P72059|EMBC|Rv3793|MTCY13D12.27 indolylacetylinositol arabinosyltransferase from Mycobacterium tuberculosis (1094 aa)%2C FASTA scores: opt: 2276%2C E(): 3.6e-123%2C (44.45%25 identity in 1118 aa overlap)%3B and P72060|EMBA|Rv3794|MTCY13D12.28 indolylacetylinositol arabinosyltransferase from Mycobacterium tuberculosis (1094 aa)%2C FASTA scores: opt: 1288%2C E(): 2.5e-66%2C (42.35%25 identity in 1114 aa overlap). Supposedly regulated by embR|Rv1267c. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=embB;locus_tag=Rv3795;product=Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase);protein_id=CCP46624.1;transl_table=11
AL123456.3	EMBL	gene	4249878	4251005	.	+	.	ID=gene-Rv3796;Name=Rv3796;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3796
AL123456.3	EMBL	CDS	4249878	4251005	.	+	0	ID=cds-CCP46625.1;Parent=gene-Rv3796;Dbxref=EnsemblGenomes-Gn:Rv3796,EnsemblGenomes-Tr:CCP46625,InterPro:IPR001279,UniProtKB/TrEMBL:P72062,NCBI_GP:CCP46625.1;Name=CCP46625.1;Note=Rv3796%2C (MTV026.01-MTCY13D12.30)%2C len: 375 aa. Conserved protein. C-terminal end similar in part to Q983J3|MLR8305 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (227 aa)%2C FASTA scores: opt: 288%2C E(): 4e-09%2C (38.95%25 identity in 154 aa overlap). Similar to P54548|YQJK_BACSU hypothetical protein (belongs to the ATSA/ELAC family) from Bacillus subtilis (307 aa) FASTA scores: opt: 263%2C E(): 1.3e-07%2C (26.1%25 identity in 295 aa overlap)%3B and some similarity to other proteins e.g. AAK46775|MT2479 putative arylsulfatase from Mycobacterium tuberculosis strain CDC1551 (224 aa)%2C FASTA scores: opt: 194%2C E(): 0.00072%2C (25.85%25 identity in 259 aa overlap). Equivalent to AAK48269 from Mycobacterium tuberculosis strain CDC1551 (338 aa) but longer 37 aa. Some similarity to the A. carrageenovora AtsA / E. coli ElaC family. Note that previously known as atsH. Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3796;product=Conserved protein;protein_id=CCP46625.1;transl_table=11
AL123456.3	EMBL	gene	4251085	4252866	.	+	.	ID=gene-Rv3797;Name=fadE35;gbkey=Gene;gene=fadE35;gene_biotype=protein_coding;locus_tag=Rv3797
AL123456.3	EMBL	CDS	4251085	4252866	.	+	0	ID=cds-CCP46626.1;Parent=gene-Rv3797;Dbxref=EnsemblGenomes-Gn:Rv3797,EnsemblGenomes-Tr:CCP46626,GOA:O53577,InterPro:IPR006091,InterPro:IPR009075,InterPro:IPR009100,UniProtKB/TrEMBL:O53577,NCBI_GP:CCP46626.1;Name=CCP46626.1;Note=Rv3797%2C (MTV026.02)%2C len: 593 aa. Probable fadE35%2Cacyl-CoA dehydrogenase%2C similar to many e.g. Q9HY33|PA3593 from Pseudomonas aeruginosa (575 aa) FASTA scores: opt: 838%2C E(): 2.1e-46%2C (35.3%25 identity in 569 aa overlap)%3B Q9ANZ8|AIDB from Burkholderia pseudomallei (Pseudomonas pseudomallei) (554 aa)%2C FASTA scores: opt: 633%2C E(): 3.4e-33%2C (33.1%25 identity in 480 aa overlap)%3B Q9HX44|PA3972 from Pseudomonas aeruginosa (549 aa) FASTA scores: opt: 560%2C E(): 1.7e-28%2C (29.9%25 identity in 569 aa overlap)%3B P33224|AIDB_ECOLI|B4187 from Escherichia coli strain K12 (541 aa)%2C FASTA scores: opt: 455%2C E(): 1e-21%2C (31.15%25 identity in 514 aa overlap)%3B etc. Also similar to O86368|FADE8|Rv0672|MTCI376.02c acyl-CoA dehydrogenase from Mycobacterium tuberculosis (542 aa)%2C FASTA scores: opt: 479%2C E(): 2.9e-23%2C (32.2%25 identity in 460 aa overlap). Could belong to the acyl-CoA dehydrogenases family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadE35;locus_tag=Rv3797;product=Probable acyl-CoA dehydrogenase FadE35;protein_id=CCP46626.1;transl_table=11
AL123456.3	EMBL	gene	4252993	4254327	.	+	.	ID=gene-Rv3798;Name=Rv3798;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3798
AL123456.3	EMBL	CDS	4252993	4254327	.	+	0	ID=cds-CCP46627.1;Parent=gene-Rv3798;Dbxref=EnsemblGenomes-Gn:Rv3798,EnsemblGenomes-Tr:CCP46627,GOA:P9WKH7,InterPro:IPR002560,InterPro:IPR029261,NCBI_GP:CCP46627.1;Name=CCP46627.1;Note=Rv3798%2C (MTV026.03)%2C len: 444 aa. Probable transposase for insertion sequence element IS1557%2C highly similar to Q60255 similar to transposase of ISAE1 from alcaligenes eutrophus H1-4 (fragment) from dibenzofuran-degrading bacterium DPO360 (163 aa) FASTA scores: opt: 767%2C E(): 3.2e-42%2C (67.25%25 identity in 168 aa overlap)%3B and similar to P74920 transposase from Thiobacillus ferrooxidans (404 aa)%2C FASTA scores: opt: 375%2CE(): 1.1e-16%2C (27.55%25 identity in 439 aa overlap)%3B Q48349 transposase from Alcaligenes eutrophus (Ralstonia eutropha) (408 aa)%2C FASTA scores: opt: 324%2C E(): 2e-13%2C (3.9%25 identity in 369 aa overlap)%3B Q9FDC1|TNP transposase from Burkholderia mallei (Pseudomonas mallei) (386 aa) FASTA scores: opt: 282%2C E(): 9.8e-11%2C (25.85%25 identity in 391 aa overlap)%3B etc. C-terminal end identical to O53804|Rv0741|MTV041.15 transposase from Mycobacterium tuberculosis (104 aa)%2C FASTA scores: opt: 582%2C E(): 1.8e-30%2C (85.6%25 identity in 104 aa overlap). Belongs to the transposase family 12.;gbkey=CDS;locus_tag=Rv3798;product=Probable transposase;protein_id=CCP46627.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	4252993	4254324	.	+	.	ID=id-Rv3798;Note=IS1557-3%2C len: 1332 nt. Insertion sequence IS1557.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1557-3
AL123456.3	EMBL	gene	4254380	4255948	.	-	.	ID=gene-Rv3799c;Name=accD4;gbkey=Gene;gene=accD4;gene_biotype=protein_coding;locus_tag=Rv3799c
AL123456.3	EMBL	CDS	4254380	4255948	.	-	0	ID=cds-CCP46628.1;Parent=gene-Rv3799c;Dbxref=EnsemblGenomes-Gn:Rv3799c,EnsemblGenomes-Tr:CCP46628,GOA:O53578,InterPro:IPR000022,InterPro:IPR011762,InterPro:IPR011763,InterPro:IPR029045,UniProtKB/TrEMBL:O53578,NCBI_GP:CCP46628.1;Name=CCP46628.1;Note=Rv3799c%2C (MTV026.04c)%2C len: 522 aa. Probable accD4%2Cpropionyl-CoA carboxylase beta chain 4%2C equivalent to Q9CDB0|ACCD4|ML0102 putative acyl CoA carboxylase from Mycobacterium leprae (517 aa) FASTA scores: opt: 3154%2C E(): 8e-187%2C (91.2%25 identity in 511 aa overlap). Also similar to many e.g. Q9X4K7|PCCB from Streptomyces coelicolor (530 aa)%2C FASTA scores: opt: 1714%2C E(): 4.4e-98%2C (50.0%25 identity in 510 aa overlap)%3B P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa)%2C FASTA scores: opt: 1549%2C E(): 6.6e-88%2C (50.65%25 identity in 519 aa overlap)%3B Q9WZH5|TM0716 from Thermotoga maritima (515 aa) FASTA scores: opt: 1529%2C E(): 1.1e-86%2C(46.7%25 identity in 512 aa overlap)%3B etc. Also similar to P53002|PCCB_MYCLE|ACCD5|PCCB|ML0731|B1308_C1_125 probable propionyl-CoA carboxylase beta chain 5 from Mycobacterium leprae (549 aa)%2C FASTA scores: opt: 1493%2C E(): 1.9e-84%2C(49.8%25 identity in 514 aa overlap)%3B and P96885|PCC5_MYCTU|ACCD5|PCCB|Rv3280|MT3379.1|MTCY71.20 probable propionyl-CoA carboxylase beta chain 5 from Mycobacterium tuberculosis (548 aa)%2C FASTA scores: opt: 1471%2C E(): 4.2e-83%2C (49.15%25 identity in 515 aa overlap). Belongs to the ACCD/PCCB family. Length extended since first submission (+5 aa). AccA3 (Rv3285)%2C AccD5 (Rv3280)%2CAccD4 (Rv3799)%2C and AccE5 (Rv3281) form a biotin-dependent acyl-CoA carboxylase in M. tuberculosis H37Rv (See Oh et al.%2C 2006).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=accD4;locus_tag=Rv3799c;product=Probable propionyl-CoA carboxylase beta chain 4 AccD4 (pccase) (propanoyl-CoA:carbon dioxide ligase);protein_id=CCP46628.1;transl_table=11
AL123456.3	EMBL	gene	4255945	4261146	.	-	.	ID=gene-Rv3800c;Name=pks13;gbkey=Gene;gene=pks13;gene_biotype=protein_coding;locus_tag=Rv3800c
AL123456.3	EMBL	CDS	4255945	4261146	.	-	0	ID=cds-CCP46629.1;Parent=gene-Rv3800c;Dbxref=EnsemblGenomes-Gn:Rv3800c,EnsemblGenomes-Tr:CCP46629,GOA:I6X8D2,InterPro:IPR001031,InterPro:IPR001227,InterPro:IPR009081,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020806,InterPro:IPR029058,UniProtKB/TrEMBL:I6X8D2,NCBI_GP:CCP46629.1;Name=CCP46629.1;Note=Rv3800c%2C (MTV026.05c)%2C len: 1733 aa. Probable pks13%2Cpolyketide synthase%2C equivalent to Q9CDB1|PKS13|ML0101 polyketide synthase from Mycobacterium leprae (1784 aa)%2CFASTA scores: opt: 7454%2C E(): 0%2C (83.6%25 identity in 1748 aa overlap)%3B and similar to Q9Z5K6|ML2357|MLCB12.02c putative polyketide synthase from Mycobacterium leprae (1871 aa)%2CFASTA scores: opt: 1682%2C E(): 1.2e-85%2C (38.3%25 identity in 1096 aa overlap). Also similar in part to many e.g. Q9ADL6|SORA soraphen polyketide synthase a from Polyangium cellulosum (6315 aa) FASTA scores: opt: 1422%2C E(): 1e-70%2C(31.45%25 identity in 1616 aa overlap)%3B AAK73501|AMPHI AMPHI protein (involved in amphotericin biosynthesis) from Streptomyces nodosus (9510 aa)%2C FASTA scores: opt: 1441%2CE(): 1.2e-71%2C (30.45%25 identity in 1662 aa overlap)%3B Q9RFL0|MTAB MTAB protein (involved in myxothiazol biosynthesis) from Stigmatella aurantiaca (4003 aa)%2C FASTA scores: opt: 1429%2C E(): 2.8e-71%2C (33.8%25 identity in 1089 aa overlap)%3B Q9L4X2|NYSJ from Streptomyces noursei (5435 aa)%2CFASTA scores: opt: 1407%2C E(): 6.1e-70%2C (30.5%25 identity in 1764 aa overlap)%3B CAC37876|SC1G7.01c from Streptomyces coelicolor (3489 aa) FASTA scores: opt: 1382%2C E(): 1e-68%2C(31.05%25 identity in 1489 aa overlap)%3B etc. Also highly similar to Q10977|PPSA_MYCTU|Rv2931|MT3000|MTCY338.20 phenolpthiocerol synthesis polyketide synthase from Mycobacterium tuberculosis (1876 aa)%2C FASTA scores: opt: 1728%2C E(): 3.4e-88%2C (36.95%25 identity in 1269 aa overlap)%3B and P96203|PPSD|Rv2934|MTCY19H9.02. Contains PS00606 Beta-ketoacyl synthases active site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks13;inference=protein motif:PROSITE:PS00606;locus_tag=Rv3800c;product=Polyketide synthase Pks13;protein_id=CCP46629.1;transl_table=11
AL123456.3	EMBL	gene	4261153	4263066	.	-	.	ID=gene-Rv3801c;Name=fadD32;gbkey=Gene;gene=fadD32;gene_biotype=protein_coding;locus_tag=Rv3801c
AL123456.3	EMBL	CDS	4261153	4263066	.	-	0	ID=cds-CCP46630.1;Parent=gene-Rv3801c;Dbxref=EnsemblGenomes-Gn:Rv3801c,EnsemblGenomes-Tr:CCP46630,GOA:O53580,InterPro:IPR000873,NCBI_GP:CCP46630.1;Name=CCP46630.1;Note=Rv3801c%2C (MTV026.06c)%2C len: 637 aa. FadD32%2Cfatty-acid-AMP synthetase%2C equivalent to Q9CDB2|FADD32|ML0100 putative acyl-CoA synthetase from Mycobacterium leprae (635 aa)%2C FASTA scores: opt: 3892%2CE(): 0%2C (93.05%25 identity in 632 aa overlap)%3B and highly similar to others from Mycobacterium leprae. Also similar to others from Mycobacterium tuberculosis e.g. P95288|FADD31|Rv1925|MTCY09F9.39c (620 aa)%2C FASTA scores: opt: 1567%2C E(): 1.7e-88%2C (47.05%25 identity in 612 aa overlap)%3B MTCY338_18%2C MTCY349_40%2C MTV005_21%2C MTCY24G1_8%2CMTCY19G5_7%2C MTCY4D9_17%3B and MBU75685_1 acyl-CoA ligase from Mycobacterium bovis.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD32;locus_tag=Rv3801c;product=Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity.;protein_id=CCP46630.1;transl_table=11
AL123456.3	EMBL	gene	4263355	4264365	.	-	.	ID=gene-Rv3802c;Name=Rv3802c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3802c
AL123456.3	EMBL	CDS	4263355	4264365	.	-	0	ID=cds-CCP46631.1;Parent=gene-Rv3802c;Dbxref=EnsemblGenomes-Gn:Rv3802c,EnsemblGenomes-Tr:CCP46631,GOA:O53581,InterPro:IPR000675,InterPro:IPR029058,UniProtKB/TrEMBL:O53581,NCBI_GP:CCP46631.1;Name=CCP46631.1;Note=Rv3802c%2C (MTV026.07c)%2C len: 336 aa. Probable conserved membrane protein%2C with a N-terminal signal sequence followed by Pro-rich region. Equivalent to Q9CDB3|ML0099 hypothetical protein from Mycobacterium leprae (336 aa) FASTA scores: opt: 1759%2C E(): 1.1e-85%2C(75.5%25 identity in 335 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3802c;product=Probable conserved membrane protein;protein_id=CCP46631.1;transl_table=11
AL123456.3	EMBL	gene	4264563	4265462	.	-	.	ID=gene-Rv3803c;Name=fbpD;gbkey=Gene;gene=fbpD;gene_biotype=protein_coding;gene_synonym=fbpC1,mpb51,mpt51;locus_tag=Rv3803c
AL123456.3	EMBL	CDS	4264563	4265462	.	-	0	ID=cds-CCP46632.1;Parent=gene-Rv3803c;Dbxref=EnsemblGenomes-Gn:Rv3803c,EnsemblGenomes-Tr:CCP46632,GOA:P9WQN7,InterPro:IPR000801,InterPro:IPR029058,PDB:1R88,NCBI_GP:CCP46632.1;Name=CCP46632.1;Note=Rv3803c%2C (MT3910%2C MTV026.08c)%2C len: 299 aa. FbpD (alternate gene names: mpt51%2C mpb51%2C fbpC1)%2C secreted MPB51/MPT51 antigen protein (fibronectin-binding protein C) (mycolyl transferase 85C) (see citations below)%2C identical to Q48923|MPT51|MPB51 antigen precursor from Mycobacterium bovis (299 aa)%2C FASTA scores: opt: 2093%2C E(): 1.5e-112%2C(100.0%25 identity in 299 aa overlap) (see Ohara et al.%2C1995)%3B and highly similar to other Mycobacterial antigen precursors e.g. Q05868|MPT5_MYCLE|MPT51|ML0098 MPT51 antigen precursor from Mycobacterium leprae (301 aa)%2C FASTA scores: opt: 1624%2C E(): 9.8e-86%2C (77.8%25 identity in 302 aa overlap)%3B O52972|A85C_MYCAV|FBPC antigen 85-C precursor (fibronectin-binding protein C) from Mycobacterium avium (352 aa)%2C FASTA scores: opt: 753%2C E(): 6.6e-36%2C (41.5%25 identity in 315 aa overlap)%3B P21160|A85B_MYCKA antigen 85-B precursor (fibronectin-binding protein B) from Mycobacterium kansasii (325 aa)%2C FASTA scores: opt: 574%2CE(): 1.1e-25%2C (37.55%25 identity in 309 aa overlap)%3B P12942|A85B_MYCBO antigen 85-B precursor from Mycobacterium bovis (323 aa)%2C FASTA scores: opt: 572%2C E(): 1.4e-25%2C(39.85%25 identity in 291 aa overlap)%3B etc. Also similar to P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 secreted antigen 85-C (mycolyl transferase 85C) (fibronectin-binding protein C) from Mycobacterium tuberculosis (340 aa)%2C FASTA scores: opt: 751%2C E(): 8.4e-36%2C (40.65%25 identity in 310 aa overlap)%3B P17944|A85A_MYCTU|FBPA|MPT44|Rv3804c|MT3911|MTV026.09c secreted antigen 85-a (mycolyl transferase 85A) (fibronectin-binding protein A) from Mycobacterium tuberculosis (338 aa)%2C FASTA scores: opt: 592%2C E(): 1e-26%2C(39.05%25 identity in 302 aa overlap)%3B etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Note that the secreted protein MPB51 is one of the major proteins in the culture filtrate of Mycobacterium bovis BCG. Note that overexpression in an FbpC-deficient M. tuberculosis clinical isolate has no effect on the amount of cell wall-linked mycolates (See Puech et al.%2C 2002).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fbpD;inference=protein motif:PROSITE:PS00178;locus_tag=Rv3803c;product=Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C);protein_id=CCP46632.1;transl_table=11
AL123456.3	EMBL	gene	4265642	4266658	.	-	.	ID=gene-Rv3804c;Name=fbpA;gbkey=Gene;gene=fbpA;gene_biotype=protein_coding;gene_synonym=85A,mpt44;locus_tag=Rv3804c
AL123456.3	EMBL	CDS	4265642	4266658	.	-	0	ID=cds-CCP46633.1;Parent=gene-Rv3804c;Dbxref=EnsemblGenomes-Gn:Rv3804c,EnsemblGenomes-Tr:CCP46633,GOA:P9WQP3,InterPro:IPR000801,InterPro:IPR006311,InterPro:IPR029058,PDB:1SFR,NCBI_GP:CCP46633.1;Name=CCP46633.1;Note=Rv3804c%2C (MT3911%2C MTV026.09c)%2C len: 338 aa. FbpA (alternate gene names: mpt44%2C 85A)%2C precursor of the 85-a antigen (fibronectin-binding protein A) (mycolyl transferase 85A) (see citations below)%2C identical to P17944|P17996|FBPA|MPT44 antigen 85-a precursor from Mycobacterium bovis (338 aa)%2C FASTA scores: opt: 2341%2C E(): 1.2e-132%2C (100.0%25 identity in 338 aa overlap)%3B and highly similar to other Mycobacterial antigen precursors e.g. O52956|A85A_MYCAV|FBPA antigen 85-a precursor (85A) from Mycobacterium avium (347 aa)%2C FASTA scores: opt: 1987%2C E(): 1.7e-111%2C (82.55%25 identity in 338 aa overlap)%3B Q05861|A85A_MYCLE|FBPA|ML0097 antigen 85-a precursor (85A) from Mycobacterium leprae (330 aa)%2C FASTA scores: opt: 1936%2C E(): 1.9e-108%2C (83.0%25 identity in 329 aa overlap)%3B O06052|A85A_MYCGO|FBPA antigen 85-a precursor (85A) from Mycobacterium gordonae (339 aa)%2C FASTA scores: opt: 1932%2CE(): 3.3e-108%2C (80.45%25 identity in 338 aa overlap)%3B etc. Also highly similar to P31952|A85B_MYCTU|FBPB|Rv1886c|MT1934|MTCY180.32 secreted antigen 85-B from Mycobacterium tuberculosis (325 aa)%2CFASTA scores: opt: 1830%2C E(): 3.9e-102%2C (78.85%25 identity in 317 aa overlap)%3B P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2 secreted antigen 85-C from Mycobacterium tuberculosis (340 aa)%2C FASTA scores: opt: 1597%2C E(): 3.4e-88%2C (67.25%25 identity in 336 aa overlap). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fbpA;locus_tag=Rv3804c;product=Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A);protein_id=CCP46633.1;transl_table=11
AL123456.3	EMBL	gene	4266953	4268836	.	-	.	ID=gene-Rv3805c;Name=aftB;gbkey=Gene;gene=aftB;gene_biotype=protein_coding;locus_tag=Rv3805c
AL123456.3	EMBL	CDS	4266953	4268836	.	-	0	ID=cds-CCP46634.1;Parent=gene-Rv3805c;Dbxref=EnsemblGenomes-Gn:Rv3805c,EnsemblGenomes-Tr:CCP46634,GOA:O53582,NCBI_GP:CCP46634.1;Name=CCP46634.1;Note=Rv3805c%2C (MTV026.10c)%2C len: 627 aa. Possible aftB%2Carabinofuranosyltransferase (See Seidel et al.%2C 2007). Probable conserved transmembrane protein%2C equivalent%2C but shorter 19 aa%2C to Q9CDB4|ML0096 putative membrane protein from Mycobacterium leprae (649 aa)%2C FASTA scores: opt: 3511%2C E(): 1.1e-204%2C (80.9%25 identity in 629 aa overlap). Equivalent to AAK48278 from Mycobacterium tuberculosis strain CDC1551 (641 aa) but shorter 14 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=aftB;locus_tag=Rv3805c;product=Possible arabinofuranosyltransferase AftB;protein_id=CCP46634.1;transl_table=11
AL123456.3	EMBL	gene	4268925	4269833	.	-	.	ID=gene-Rv3806c;Name=ubiA;gbkey=Gene;gene=ubiA;gene_biotype=protein_coding;locus_tag=Rv3806c
AL123456.3	EMBL	CDS	4268925	4269833	.	-	0	ID=cds-CCP46635.1;Parent=gene-Rv3806c;Dbxref=EnsemblGenomes-Gn:Rv3806c,EnsemblGenomes-Tr:CCP46635,GOA:P9WFR5,InterPro:IPR000537,NCBI_GP:CCP46635.1;Name=CCP46635.1;Note=Rv3806c%2C (MTV026.11c)%2C len: 302 aa. UbiA%2Cdecaprenylphosphoryl-5-phosphoribose (DPPR) synthase (See Huang et al.%2C 2005)%2C equivalent to Q9CDB5|ML0095 putative integral membrane protein from Mycobacterium leprae (302 aa)%2C FASTA scores: opt: 1677%2C E(): 3.9e-103%2C (83.75%25 identity in 302 aa overlap). Also highly similar to others e.g. Q9KZA2|SC5G8.12 putative integral membrane protein from Streptomyces coelicolor (322 aa)%2C FASTA scores: opt: 937%2C E(): 2e-54%2C (51.4%25 identity in 292 aa overlap)%3B AAK79783|CAC1818 conserved membrane protein%2C possible 4-hydroxybenzoate from Clostridium acetobutylicum (290 aa)%2CFASTA scores: opt: 467%2C E(): 1.5e-23%2C (26.9%25 identity in 290 aa overlap)%3B Q98KY3|MLL1266 nodulation protein NOEC (potential integral membrane protein) from Rhizobium loti (Mesorhizobium loti) (297 aa)%2C FASTA scores: opt: 331%2C E(): 1.4e-14%2C (27.4%25 identity in 299 aa overlap)%3B etc. And highly similar to C-terminal part of Q981F8|MLR9393 nodulation protein NOEC (potential integral membrane protein) from Rhizobium loti (Mesorhizobium loti) plasmid pMLa (541 aa)%2C FASTA scores: opt: 388%2C E(): 4e-18%2C (30.9%25 identity in 301 aa overlap)%3B and P55585|Y4NM_RHISN integral membrane protein (possible permease/transporter) from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (516 aa)%2CFASTA scores: opt: 380%2C E(): 1.3e-17%2C (31.85%25 identity in 295 aa overlap). Contains PS00225 Crystallins beta and gamma 'Greek key' motif signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ubiA;inference=protein motif:PROSITE:PS00225;locus_tag=Rv3806c;product=Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase (decaprenyl-phosphate 5-phosphoribosyltransferase);protein_id=CCP46635.1;transl_table=11
AL123456.3	EMBL	gene	4269840	4270337	.	-	.	ID=gene-Rv3807c;Name=Rv3807c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3807c
AL123456.3	EMBL	CDS	4269840	4270337	.	-	0	ID=cds-CCP46636.1;Parent=gene-Rv3807c;Dbxref=EnsemblGenomes-Gn:Rv3807c,EnsemblGenomes-Tr:CCP46636,GOA:P9WI53,InterPro:IPR000326,NCBI_GP:CCP46636.1;Name=CCP46636.1;Note=Rv3807c%2C (MTV026.12)%2C len: 165 aa. Possible conserved transmembrane protein%2C equivalent to Q9CDB6|ML0094 putative membrane protein from Mycobacterium leprae (192 aa)%2C FASTA scores: opt: 714%2C E(): 2.4e-38%2C(72.85%25 identity in 151 aa overlap). Also highly similar to Q9KZA3|SC5G8.11 putative integral membrane protein from Streptomyces coelicolor (169 aa)%2C FASTA scores: opt: 324%2CE(): 1.1e-13%2C (41.5%25 identity in 159 aa overlap)%3B and similar in part to others e.g. Q9K3L3|SCG20A.27 putative integral membrane protein from Streptomyces coelicolor (230 aa)%2C FASTA scores: opt: 277%2C E(): 1.3e-10%2C (41.65%25 identity in 168 aa overlap)%3B P72269|ORF8 hypothetical protein from Rhodococcus erythropolis (487 aa) FASTA scores: opt: 229%2CE(): 2.7e-07%2C (36.25%25 identity in 149 aa overlap)%3B O86625|SC3A7.24c putative integral membrane protein from Streptomyces coelicolor (201 aa) FASTA scores: opt: 200%2CE(): 9.1e-06%2C (34.95%25 identity in 146 aa overlap)%3B Q9KYD7|SCD72A.19 putative integral membrane protein from Streptomyces coelicolor (238 aa) FASTA scores: opt: 178%2CE(): 0.00026%2C (35.7%25 identity in 112 aa overlap)%3B etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3807c;product=Possible conserved transmembrane protein;protein_id=CCP46636.1;transl_table=11
AL123456.3	EMBL	gene	4270366	4272279	.	-	.	ID=gene-Rv3808c;Name=glfT2;gbkey=Gene;gene=glfT2;gene_biotype=protein_coding;locus_tag=Rv3808c
AL123456.3	EMBL	CDS	4270366	4272279	.	-	0	ID=cds-CCP46637.1;Parent=gene-Rv3808c;Dbxref=EnsemblGenomes-Gn:Rv3808c,EnsemblGenomes-Tr:CCP46637,GOA:O53585,InterPro:IPR029044,PDB:4FIX,PDB:4FIY,NCBI_GP:CCP46637.1;Name=CCP46637.1;Note=Rv3808c%2C (MTV026.13c)%2C len: 637 aa. GlfT2%2Cbifunctional UDP-galactofuranosyl transferase (see citations below). Equivalent to Q9CDB7|ML0093 hypothetical protein from Mycobacterium leprae (643 aa)%2C FASTA scores: opt: 3751%2C E(): 0%2C (85.4%25 identity in 643 aa overlap). Contains a beta-glycosyltransferase domain A. Note that previously known as glfT. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glfT2;locus_tag=Rv3808c;product=Bifunctional UDP-galactofuranosyl transferase GlfT2;protein_id=CCP46637.1;transl_table=11
AL123456.3	EMBL	gene	4272276	4273475	.	-	.	ID=gene-Rv3809c;Name=glf;gbkey=Gene;gene=glf;gene_biotype=protein_coding;gene_synonym=ceoA;locus_tag=Rv3809c
AL123456.3	EMBL	CDS	4272276	4273475	.	-	0	ID=cds-CCP46638.1;Parent=gene-Rv3809c;Dbxref=EnsemblGenomes-Gn:Rv3809c,EnsemblGenomes-Tr:CCP46638,GOA:P9WIQ1,InterPro:IPR004379,InterPro:IPR015899,InterPro:IPR016040,PDB:1V0J,NCBI_GP:CCP46638.1;Name=CCP46638.1;Note=Rv3809c%2C (MTV026.14)%2C len: 399 aa. Glf (alternate gene name: ceoA)%2C UDP-galactopyranose mutase (see citations below)%2C identical to previously sequenced gene%2C and equivalent to Q9CDB8|GLF|ML0092 putative UDP-galactopyranose mutase from Mycobacterium leprae (413 aa)%2C FASTA scores: opt: 2347%2C E(): 1.3e-140%2C (86.6%25 identity in 396 aa overlap). Also highly similar to others e.g. AAK61905|EPSJ UDP-galactopyranose mutase (protein involved in exopolysaccharides biosynthesis) from Streptococcus thermophilus (365 aa)%2C FASTA scores: opt: 972%2C E(): 5.9e-54%2C (45.85%25 identity in 375 aa overlap)%3B P37747|GLF_ECOLI|B2036 UDP-galactopyranose mutase from Escherichia coli strain K12 (367 aa)%2C FASTA scores: opt: 958%2C E(): 4.5e-53%2C (43.55%25 identity in 379 aa overlap)%3B O86897|CAP33FN from Streptococcus pneumoniae (369 aa) FASTA scores: opt: 954%2C E(): 8.1e-53%2C (44.8%25 identity in 375 aa overlap)%3B etc. Cofactor: FAD (by similarity). N-terminal SHOWS similarity to FAD or NAD containing proteins.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glf;locus_tag=Rv3809c;product=UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme);protein_id=CCP46638.1;transl_table=11
AL123456.3	EMBL	gene	4273739	4274593	.	+	.	ID=gene-Rv3810;Name=pirG;gbkey=Gene;gene=pirG;gene_biotype=protein_coding;gene_synonym=erp,P36;locus_tag=Rv3810
AL123456.3	EMBL	CDS	4273739	4274593	.	+	0	ID=cds-CCP46639.1;Parent=gene-Rv3810;Dbxref=EnsemblGenomes-Gn:Rv3810,EnsemblGenomes-Tr:CCP46639,GOA:P9WIQ7,InterPro:IPR008164,NCBI_GP:CCP46639.1;Name=CCP46639.1;Note=Rv3810%2C (MTV026.15)%2C len: 284 aa. PirG (alternate gene names: P36 or erp for Exported Repeated Protein)%2C cell surface protein precursor (see citations below)%2C equivalent to P19361|28KD_MYCLE|ML0091 28 KDA antigen precursor from Mycobacterium leprae (236 aa)%2C FASTA scores: opt: 555%2C E(): 9.8e-18%2C (52.65%25 identity in 281 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;gene=pirG;locus_tag=Rv3810;product=Exported repetitive protein precursor PirG (cell surface protein) (EXP53);protein_id=CCP46639.1;transl_table=11
AL123456.3	EMBL	gene	4274798	4276417	.	+	.	ID=gene-Rv3811;Name=Rv3811;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3811
AL123456.3	EMBL	CDS	4274798	4276417	.	+	0	ID=cds-CCP46640.1;Parent=gene-Rv3811;Dbxref=EnsemblGenomes-Gn:Rv3811,EnsemblGenomes-Tr:CCP46640,GOA:Q79F96,InterPro:IPR002502,InterPro:IPR006619,InterPro:IPR013207,InterPro:IPR015510,UniProtKB/TrEMBL:Q79F96,NCBI_GP:CCP46640.1;Name=CCP46640.1;Note=Rv3811%2C (MTV026.16)%2C len: 539 aa. Conserved hypothetical protein%2C showing some similarity to Q9KZK5|SCE34.21c putative secreted protein from Streptomyces coelicolor (416 aa)%2C FASTA scores: opt: 603%2CE(): 8.1e-26%2C (34.4%25 identity in 404 aa overlap)%3B Q9S2P9|SC5F7.14c hypothetical 31.9 KDA protein from Streptomyces coelicolor (308 aa)%2C FASTA scores: opt: 472%2CE(): 9.5e-19%2C (37.5%25 identity in 208 aa overlap). Middle section (approximately aa 185-350/390) shows some similarity with Q9GK12 peptidoglycan recognition protein precursor from Camelus dromedarius (Dromedary) (Arabian camel) (193 aa) FASTA scores: opt: 274%2C E(): 4.6e-08%2C(32.2%25 identity in 177 aa overlap)%3B O75594|PGLYRP|PGRP from Homo sapiens (Human) (196 aa)%2C FASTA scores: opt: 272%2C E(): 6e-08%2C (30.9%25 identity in 220 aa overlap)%3B Q9JLN4|PGRP peptidoglycan recognition protein from Rattus norvegicus (Rat) (182 aa)%2C FASTA scores: opt: 253%2C E(): 6.2e-07%2C(32.15%25 identity in 171 aa overlap)%3B etc. C-terminal end shows similarity with Q01377|CSP1_CORGL PS1 protein precursor (one of the two major secreted proteins) from Corynebacterium glutamicum (Brevibacterium flavum) (657 aa)%2C FASTA scores: opt: 250%2C E(): 2.7e-06%2C (39.45%25 identity in 109 aa overlap). Contains PS00687 Aldehydedehydrogenases glutamic acid active site. Note that previously known as csp.;gbkey=CDS;inference=protein motif:PROSITE:PS00687;locus_tag=Rv3811;product=Conserved hypothetical protein;protein_id=CCP46640.1;transl_table=11
AL123456.3	EMBL	gene	4276571	4278085	.	+	.	ID=gene-Rv3812;Name=PE_PGRS62;gbkey=Gene;gene=PE_PGRS62;gene_biotype=protein_coding;locus_tag=Rv3812
AL123456.3	EMBL	CDS	4276571	4278085	.	+	0	ID=cds-CCP46641.1;Parent=gene-Rv3812;Dbxref=EnsemblGenomes-Gn:Rv3812,EnsemblGenomes-Tr:CCP46641,InterPro:IPR000084,UniProtKB/TrEMBL:L7N680,NCBI_GP:CCP46641.1;Name=CCP46641.1;Note=Rv3812%2C (MTV026.17%2C MTCY409.18c)%2C len: 504 aa. PE_PGRS62%2C Member of the Mycobacterium tuberculosis PE family%2C PGRS subfamily of gly-rich proteins (see citations below)%2C similar to many e.g. P96828|Rv0151c|MTCI5.25c (588 aa)%2C FASTA scores: opt: 389%2C E(): 6.2e-14%2C (29.2%25 identity in 473 aa overlap)%3B MTCY7H7B_27%3B MTCY493_24%3B MTCY441_4%3B MTCY39_36%3B MTCY1A11_4%3B MTCY359_33%3B MTCY130_10%3B MTCY98_9%3B etc. The transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al.%2C 2000).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE_PGRS62;locus_tag=Rv3812;product=PE-PGRS family protein PE_PGRS62;protein_id=CCP46641.1;transl_table=11
AL123456.3	EMBL	gene	4278394	4279215	.	-	.	ID=gene-Rv3813c;Name=Rv3813c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3813c
AL123456.3	EMBL	CDS	4278394	4279215	.	-	0	ID=cds-CCP46642.1;Parent=gene-Rv3813c;Dbxref=EnsemblGenomes-Gn:Rv3813c,EnsemblGenomes-Tr:CCP46642,GOA:O07810,InterPro:IPR000150,InterPro:IPR006379,InterPro:IPR023214,UniProtKB/TrEMBL:O07810,NCBI_GP:CCP46642.1;Name=CCP46642.1;Note=Rv3813c%2C (MTCY409.17)%2C len: 273 aa. Conserved protein%2C equivalent to Q9CDB9|ML0089 hypothetical protein from Mycobacterium leprae (281 aa) FASTA scores: opt: 1479%2CE(): 9.6e-81%2C (80.45%25 identity in 271 aa overlap)%3B and similar to Q98LI0|MLL1014 from (280 aa). Also similar to many hypothetical proteins from several organisms e.g. Q9ZBX2|SCD78.27c from Streptomyces coelicolor (280 aa)%2CFASTA scores: opt: 597%2C E(): 2.2e-28%2C (43.25%25 identity in 266 aa overlap)%3B Q9RXR7|DR0240 from Deinococcus radiodurans (284 aa)%2C FASTA scores: opt: 543%2C E(): 3.5e-25%2C (38.65%25 identity in 264 aa overlap)%3B Q99YH5|SPY1700 from Streptococcus pyogenes (274 aa) FASTA scores: opt: 373%2CE(): 4.3e-15%2C (30.75%25 identity in 270 aa overlap)%3B P70947|YITU from Bacillus subtilis (270 aa) FASTA scores: opt: 353%2C E(): 6.5e-14%2C (30.0%25 identity in 280 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3813c;product=Conserved protein;protein_id=CCP46642.1;transl_table=11
AL123456.3	EMBL	gene	4279230	4280015	.	-	.	ID=gene-Rv3814c;Name=Rv3814c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3814c
AL123456.3	EMBL	CDS	4279230	4280015	.	-	0	ID=cds-CCP46643.1;Parent=gene-Rv3814c;Dbxref=EnsemblGenomes-Gn:Rv3814c,EnsemblGenomes-Tr:CCP46643,GOA:O07809,InterPro:IPR002123,UniProtKB/TrEMBL:O07809,NCBI_GP:CCP46643.1;Name=CCP46643.1;Note=Rv3814c%2C (MTCY409.16)%2C len: 261 aa. Possible acyltransferase%2C highly similar to Q9CDC0|ML0087 putative acyltransferase from Mycobacterium leprae (257 aa)%2C FASTA scores: opt: 753%2C E(): 7.7e-42%2C (46.75%25 identity in 246 aa overlap). Also highly similar to many acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 putative acyltransferase from Streptomyces coelicolor (242 aa)%2CFASTA scores: opt: 587%2C E(): 4.6e-31%2C (41.95%25 identity in 243 aa overlap)%3B Q9ZBS1|SC7A1.02 putative acyltransferase from Streptomyces coelicolor (264 aa)%2C FASTA scores: opt: 293%2C E(): 6.6e-12%2C (29.2%25 identity in 267 aa overlap)%3B Q9PNZ5|AAS|CJ0938 putative 2-acylglycerophosphoethanolamine acyltransferase / acyl-acyl carrier protein synthetase from Campylobacter jejuni (1170 aa)%2C FASTA scores: opt: 274%2CE(): 3.9e-10%2C (29.1%25 identity in 219 aa overlap) (similarity only with middle section)%3B Q9EY25 putative acetyl transferase from Xanthomonas oryzae pv. oryzae (249 aa)%2C FASTA scores: opt: 238%2C E(): 2.4e-08%2C (29.2%25 identity in 209 aa overlap)%3B etc. Also highly similar to downstream ORFs O07808|Rv3815c|MTCY409.15 putative acyltransferase from Mycobacterium tuberculosis (251 aa)%2C FASTA scores: opt: 1069%2C E(): 2.1e-62%2C (60.4%25 identity in 245 aa overlap)%3B and O07807|Rv3816c|MTCY409.14 putative acyltransferase from Mycobacterium tuberculosis (259 aa)%2CFASTA scores: opt: 776%2C E(): 2.5e-43%2C (50.9%25 identity in 228 aa overlap). And similar to O53516|Rv2182c|MTV021.15c hypothetical 27.0 KDA protein from Mycobacterium tuberculosis (247 aa)%2C FASTA scores: opt: 239%2C E(): 2e-08%2C(30.6%25 identity in 232 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3814c;product=Possible acyltransferase;protein_id=CCP46643.1;transl_table=11
AL123456.3	EMBL	gene	4280033	4280788	.	-	.	ID=gene-Rv3815c;Name=Rv3815c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3815c
AL123456.3	EMBL	CDS	4280033	4280788	.	-	0	ID=cds-CCP46644.1;Parent=gene-Rv3815c;Dbxref=EnsemblGenomes-Gn:Rv3815c,EnsemblGenomes-Tr:CCP46644,GOA:O07808,InterPro:IPR002123,UniProtKB/TrEMBL:O07808,NCBI_GP:CCP46644.1;Name=CCP46644.1;Note=Rv3815c%2C (MTCY409.15)%2C len: 251 aa. Possible acyltransferase%2C highly similar to Q9CDC0|ML0087 putative acyltransferase from Mycobacterium leprae (257 aa)%2C FASTA scores: opt: 845%2C E(): 2.7e-47%2C (53.25%25 identity in 246 aa overlap). Also highly similar to Q9K3R3|2SCG4.01 putative acyltransferase from Streptomyces coelicolor (242 aa)%2CFASTA scores: opt: 656%2C E(): 3.7e-35%2C (47.85%25 identity in 234 aa overlap)%3B and similar to many putative acyltransferases and hypothetical proteins e.g. P74498|SLL1848 hypothetical 24.3 KDA protein from Synechocystis sp. strain PCC 6803 (225 aa) FASTA scores: opt: 275%2C E(): 1.2e-10%2C (34.8%25 identity in 181 aa overlap)%3B Q9ZBS1|SC7A1.02 putative acyltransferase from Streptomyces coelicolor (264 aa)%2C FASTA scores: opt: 266%2C E(): 5.2e-10%2C(29.7%25 identity in 229 aa overlap)%3B Q9PNZ5|AAS|CJ0938 putative 2-acylglycerophosphoethanolamine acyltransferase/ acyl-acyl carrier protein synthetase from Campylobacter jejuni (1170 aa)%2C FASTA scores: opt: 264%2C E(): 2.3e-09%2C(23.55%25 identity in 221 aa overlap) (similarity only with middle section)%3B etc. Also highly similar to upstream ORF O07809|Rv3814c|MTCY409.16 putative acyltransferase from Mycobacterium tuberculosis (261 aa)%2C FASTA scores: opt: 1069%2C E(): 1e-61%2C (60.4%25 identity in 245 aa overlap) %3B and downstream ORF O07807|Rv3816c|MTCY409.14 putative acyltransferase from Mycobacterium tuberculosis (259 aa) FASTA scores: opt: 847%2C E(): 2e-47%2C (55.7%25 identity in 246 aa overlap). And similar to O53516|Rv2182c|MTV021.15c hypothetical 27.0 KDA protein from Mycobacterium tuberculosis (247 aa)%2C FASTA scores: opt: 237%2C E(): 3.6e-08%2C (30.9%25 identity in 233 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3815c;product=Possible acyltransferase;protein_id=CCP46644.1;transl_table=11
AL123456.3	EMBL	gene	4280792	4281571	.	-	.	ID=gene-Rv3816c;Name=Rv3816c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3816c
AL123456.3	EMBL	CDS	4280792	4281571	.	-	0	ID=cds-CCP46645.1;Parent=gene-Rv3816c;Dbxref=EnsemblGenomes-Gn:Rv3816c,EnsemblGenomes-Tr:CCP46645,GOA:O07807,InterPro:IPR002123,UniProtKB/TrEMBL:O07807,NCBI_GP:CCP46645.1;Name=CCP46645.1;Note=Rv3816c%2C (MTCY409.14)%2C len: 259 aa. Possible acyltransferase%2C equivalent to Q9CDC0|ML0087 putative acyltransferase from Mycobacterium leprae (257 aa) FASTA scores: opt: 1401%2C E(): 1.5e-80%2C (81.9%25 identity in 254 aa overlap). Also highly similar to many putative acyltransferases and hypothetical proteins e.g. Q9K3R3|2SCG4.01 putative acyltransferase from Streptomyces coelicolor (242 aa)%2C FASTA scores: opt: 758%2C E(): 2.4e-40%2C(51.7%25 identity in 234 aa overlap)%3B Q9ZBS1|SC7A1.02 putative acyltransferase from Streptomyces coelicolor (264 aa)%2C FASTA scores: opt: 312%2C E(): 2e-12%2C (29.55%25 identity in 237 aa overlap)%3B O67841|AAS|AQ_2058 2-acylglycerophosphoethanolamine acyltransferase from Aquifex aeolicus (211 aa)%2C FASTA scores: opt: 281%2C E(): 1.5e-10%2C (32.7%25 identity in 162 aa overlap)%3B etc. Also highly similar to upstream ORFs O07808|Rv3815c|MTCY409.15 putative acyltransferase from Mycobacterium tuberculosis (251 aa)%2C FASTA scores: opt: 847%2C E(): 6.7e-46%2C (55.7%25 identity in 246 aa overlap)%3B and O07809|Rv3814c|MTCY409.16 putative acyltransferase from Mycobacterium tuberculosis (261 aa)%2C FASTA scores: opt: 776%2C E(): 1.9e-41%2C (50.9%25 identity in 228 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3816c;product=Possible acyltransferase;protein_id=CCP46645.1;transl_table=11
AL123456.3	EMBL	gene	4281647	4282402	.	+	.	ID=gene-Rv3817;Name=Rv3817;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3817
AL123456.3	EMBL	CDS	4281647	4282402	.	+	0	ID=cds-CCP46646.1;Parent=gene-Rv3817;Dbxref=EnsemblGenomes-Gn:Rv3817,EnsemblGenomes-Tr:CCP46646,GOA:O07806,InterPro:IPR002575,InterPro:IPR011009,InterPro:IPR024165,UniProtKB/TrEMBL:O07806,NCBI_GP:CCP46646.1;Name=CCP46646.1;Note=Rv3817%2C (MTCY409.13c)%2C len: 251 aa. Possible phosphotransferase%2C similar to many phosphotransferases e.g. O53023 kanamycin marker from Escherichia coli (264 aa)%2C FASTA scores: opt: 232%2C E(): 7.5e-08%2C (32.4%25 identity in 247 aa overlap)%3B BAA78209|NEO neomycine phosphotransferase from Drosophila melanogaster (Fruit fly) (264 aa)%2C FASTA scores: opt: 227%2C E(): 1.6e-07%2C (32.0%25 identity in 247 aa overlap)%3B AAG09774 aminoglycoside 3'-phosphotransferase from Vibrio cholerae (264 aa)%2C FASTA scores: opt: 227%2C E(): 1.6e-07%2C (32.0%25 identity in 247 aa overlap)%3B P00552|KKA2_KLEPN|NEO|KAN aminoglycoside 3'-phosphotransferase from Klebsiella pneumoniae (264 aa)%2CFASTA scores: opt: 227%2C E(): 1.6e-07%2C (32.0%25 identity in 247 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3817;product=Possible phosphotransferase;protein_id=CCP46646.1;transl_table=11
AL123456.3	EMBL	gene	4282449	4283999	.	+	.	ID=gene-Rv3818;Name=Rv3818;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3818
AL123456.3	EMBL	CDS	4282449	4283999	.	+	0	ID=cds-CCP46647.1;Parent=gene-Rv3818;Dbxref=EnsemblGenomes-Gn:Rv3818,EnsemblGenomes-Tr:CCP46647,GOA:P9WH21,InterPro:IPR001279,InterPro:IPR017941,NCBI_GP:CCP46647.1;Name=CCP46647.1;Note=Rv3818%2C (MTCY409.12c)%2C len: 516 aa. Unknown protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3818;product=Unknown protein;protein_id=CCP46647.1;transl_table=11
AL123456.3	EMBL	gene	4283996	4284331	.	+	.	ID=gene-Rv3819;Name=Rv3819;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3819
AL123456.3	EMBL	CDS	4283996	4284331	.	+	0	ID=cds-CCP46648.1;Parent=gene-Rv3819;Dbxref=EnsemblGenomes-Gn:Rv3819,EnsemblGenomes-Tr:CCP46648,UniProtKB/TrEMBL:O07804,NCBI_GP:CCP46648.1;Name=CCP46648.1;Note=Rv3819%2C (MTCY409.11c)%2C len: 111 aa. Unknown protein. Contains PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00012;locus_tag=Rv3819;product=Unknown protein;protein_id=CCP46648.1;transl_table=11
AL123456.3	EMBL	gene	4284419	4285825	.	-	.	ID=gene-Rv3820c;Name=papA2;gbkey=Gene;gene=papA2;gene_biotype=protein_coding;locus_tag=Rv3820c
AL123456.3	EMBL	CDS	4284419	4285825	.	-	0	ID=cds-CCP46649.1;Parent=gene-Rv3820c;Dbxref=EnsemblGenomes-Gn:Rv3820c,EnsemblGenomes-Tr:CCP46649,GOA:P9WIK7,InterPro:IPR001242,NCBI_GP:CCP46649.1;Name=CCP46649.1;Note=Rv3820c%2C (MTCY409.10)%2C len: 468 aa. Possible papA2%2Cconserved polyketide synthase (PKS) associated protein%2Chighly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-associated protein A3 from Mycobacterium leprae (471 aa)%2C FASTA scores: opt: 1660%2C E(): 2.7e-102%2C (53.95%25 identity in 456 aa overlap). Also similar to Q9F2R3|SCD65.19c hypothetical 52.8 KDA protein from Streptomyces coelicolor (473 aa)%2C FASTA scores: opt: 575%2CE(): 1.8e-30%2C (27.8%25 identity in 464 aa overlap)%3B and weakly similar to part of other proteins. Also high similarity with other PKS-associated proteins from Mycobacterium tuberculosis%3B O50438|PAPA3|Rv1182|MTV005.18 (472 aa)%2C FASTA scores: opt: 1694%2C E(): 1.5e-104%2C (53.8%25 identity in 461 aa overlap)%3B and O07799|PAPA1|Rv3824c|MTCY409.06 (511 aa)%2C FASTA scores: opt: 1664%2C E(): 1.6e-102%2C (53.9%25 identity in 462 aa overlap)%3B and similar to C-terminal end of O53902|PAPA4|Rv1528c|MTV045.02 (165 aa)%2C FASTA scores: opt: 186%2C E(): 4.1e-05%2C (37.9%25 identity in 66 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=papA2;locus_tag=Rv3820c;product=Possible conserved polyketide synthase associated protein PapA2;protein_id=CCP46649.1;transl_table=11
AL123456.3	EMBL	gene	4285973	4286686	.	+	.	ID=gene-Rv3821;Name=Rv3821;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3821
AL123456.3	EMBL	CDS	4285973	4286686	.	+	0	ID=cds-CCP46650.1;Parent=gene-Rv3821;Dbxref=EnsemblGenomes-Gn:Rv3821,EnsemblGenomes-Tr:CCP46650,InterPro:IPR021315,UniProtKB/TrEMBL:O07802,NCBI_GP:CCP46650.1;Name=CCP46650.1;Note=Rv3821%2C (MTCY409.09c)%2C len: 237 aa. Probable conserved integral membrane protein%2C equivalent to Q49630|ML1233|B1170_F2_64 hypothetical 24.4 KDA protein/INTEGRAL MEMBRANE PROTEIN (POTENTIAL) from Mycobacterium leprae (230 aa)%2C FASTA scores: opt: 619%2C E(): 2.4e-32%2C (46.65%25 identity in 240 aa overlap). Shows some similarity to P29466|I1BC_HUMAN|CASP1|IL1BC|IL1BCE (404 aa)%2C FASTA scores: opt: 126%2C E(): 0.88%2C (29.05%25 identity in 155 aa overlap). Also highly similar to P71796|Rv1517|MTCY277.39 HYPOTHETICAL 26.9 KDA PROTEIN from Mycobacterium tuberculosis (254 aa)%2C FASTA scores: opt: 284%2C E(): 5.4e-11%2C (36.35%25 identity in 256 aa overlap). Start site chosen on basis of similarity to LEPB1170_F2_64 and MTCY277.39%2C but may extend further upstream. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv3821;product=Probable conserved integral membrane protein;protein_id=CCP46650.1;transl_table=11
AL123456.3	EMBL	gene	4286721	4287935	.	+	.	ID=gene-Rv3822;Name=Rv3822;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3822
AL123456.3	EMBL	CDS	4286721	4287935	.	+	0	ID=cds-CCP46651.1;Parent=gene-Rv3822;Dbxref=EnsemblGenomes-Gn:Rv3822,EnsemblGenomes-Tr:CCP46651,GOA:O07801,InterPro:IPR013228,UniProtKB/TrEMBL:O07801,NCBI_GP:CCP46651.1;Name=CCP46651.1;Note=Rv3822%2C (MTCY409.08c)%2C len: 404 aa. Conserved hypothetical protein%2C similar in part to hypothetical proteins from Mycobacterium leprae: Q9CC62|ML1232 (358 aa) FASTA scores: opt: 601%2C E(): 1.1e-25%2C (36.7%25 identity in 335 aa overlap)%3B and Q49633|B1170_F3_112 (391 aa) FASTA scores: opt: 601%2C E(): 1.2e-25%2C (36.25%25 identity in 347 aa overlap). Also similar to P71862|Rv3539|MTCY03C7.17c PPE family protein from Mycobacterium tuberculosis (479 aa)%2CFASTA scores: opt: 547%2C E(): 1.3e-22%2C (38.1%25 identity in 281 aa overlap)%3B O50440|Rv1184c|MTV005.20c (359 aa)%3B O06828|Rv1430|MTCY493.24c (528 aa)%3B O53642|Rv0159c|MTV032.02c (468 aa)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3822;product=Conserved hypothetical protein;protein_id=CCP46651.1;transl_table=11
AL123456.3	EMBL	gene	4288260	4291529	.	-	.	ID=gene-Rv3823c;Name=mmpL8;gbkey=Gene;gene=mmpL8;gene_biotype=protein_coding;locus_tag=Rv3823c
AL123456.3	EMBL	CDS	4288260	4291529	.	-	0	ID=cds-CCP46652.1;Parent=gene-Rv3823c;Dbxref=EnsemblGenomes-Gn:Rv3823c,EnsemblGenomes-Tr:CCP46652,GOA:P9WJU5,InterPro:IPR000731,InterPro:IPR004869,NCBI_GP:CCP46652.1;Name=CCP46652.1;Note=Rv3823c%2C (MTCY409.07)%2C len: 1089 aa. mmpL8%2Cconserved integral membrane transport protein (see Tekaia et al.%2C 1999)%2C member of RND superfamily%2C equivalent to Q49619|MMLA_MYCLE|MMPL10|TP1|ML1231|B1170_C1_181 putative membrane protein from Mycobacterium leprae (1008 aa)%2C FASTA scores: opt: 2718%2C E(): 7.3e-149%2C (56.25%25 identity in 1028 aa overlap). Also similar to others e.g. Q9XCF6|TMTPC from Mycobacterium avium (974 aa)%2C FASTA scores: opt: 660%2C E(): 2.7e-30%2C (28.2%25 identity in 1050 aa overlap)%3B Q9XCF5|TMTPB from Mycobacterium avium (963 aa)%2C FASTA scores: opt: 653%2CE(): 6.7e-30%2C (27.0%25 identity in 1014 aa overlap)%3B Q9KH53|TMTPC from Mycobacterium smegmatis (994 aa)%2C FASTA scores: opt: 648%2C E(): 1.3e-29%2C (28.45%25 identity in 1013 aa overlap)%3B etc. Also highly similar to other mmpL proteins from Mycobacterium tuberculosis%3B O50439|MMLA_MYCTU|MMPL10|RV1183|MT1220|MTV005.19 (1002 aa)%2CFASTA scores: opt: 2777%2C E(): 2.9e-152%2C (58.25%25 identity in 996 aa overlap)%3B Q50585|MMLC_MYCTU|MMPL12|Rv1522c|MT1573|MTCY19G5.06 (1146 aa)%2C FASTA scores: opt: 2433%2C E(): 2.1e-132%2C (49.9%25 identity in 1050 aa overlap)%3B and similar to others e.g. P95235|MML9_MYCTU|MMPL9|Rv2339|MT2402|MTCY98.08 (962 aa)%2CFASTA scores: opt: 651%2C E(): 8.8e-30%2C (28.6%25 identity in 1038 aa overlap)%3B etc. Belongs to the MmpL family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mmpL8;locus_tag=Rv3823c;product=Conserved integral membrane transport protein MmpL8;protein_id=CCP46652.1;transl_table=11
AL123456.3	EMBL	gene	4291639	4293174	.	-	.	ID=gene-Rv3824c;Name=papA1;gbkey=Gene;gene=papA1;gene_biotype=protein_coding;locus_tag=Rv3824c
AL123456.3	EMBL	CDS	4291639	4293174	.	-	0	ID=cds-CCP46653.1;Parent=gene-Rv3824c;Dbxref=EnsemblGenomes-Gn:Rv3824c,EnsemblGenomes-Tr:CCP46653,GOA:P9WIK9,InterPro:IPR001242,NCBI_GP:CCP46653.1;Name=CCP46653.1;Note=Rv3824c%2C (MTCY409.06)%2C len: 511 aa. papA1%2C conserved polyketide synthase (PKS) associated protein%2C highly similar to Q49618|PAPA3|ML1230|B1170_C1_180 PKS-associated protein A3 from Mycobacterium leprae (471 aa)%2C FASTA scores: opt: 1879%2C E(): 7.1e-111%2C (55.5%25 identity in 465 aa overlap). Also similar to Q9F2R3|SCD65.19c hypothetical 52.8 KDA protein from Streptomyces coelicolor (473 aa)%2CFASTA scores: opt: 476%2C E(): 1.7e-22%2C (26.7%25 identity in 464 aa overlap)%3B and similar in part to Q09164|SIMA|CYSYN cyclosporin synthetase from Tolypocladium inflatum (15281 aa) FASTA scores: opt: 238%2C E(): 2.8e-06%2C (22.35%25 identity in 371 aa overlap). Also highly similar to other PKS-associated proteins from Mycobacterium tuberculosis%3B O50438|PAPA3|Rv1182|MTV005.18 (472 aa)%2C FASTA scores: opt: 1862%2C E(): 8.4e-110%2C (55.95%25 identity in 470 aa overlap)%3B and upstream ORF O07803|PAPA2|Rv3820c|MTCY409.10 (468 aa) FASTA scores: opt: 1664%2C E(): 2.5e-97%2C (53.9%25 identity in 462 aa overlap). Contains PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=papA1;inference=protein motif:PROSITE:PS00453;locus_tag=Rv3824c;product=Conserved polyketide synthase associated protein PapA1;protein_id=CCP46653.1;transl_table=11
AL123456.3	EMBL	gene	4293225	4299605	.	-	.	ID=gene-Rv3825c;Name=pks2;gbkey=Gene;gene=pks2;gene_biotype=protein_coding;locus_tag=Rv3825c
AL123456.3	EMBL	CDS	4293225	4299605	.	-	0	ID=cds-CCP46654.1;Parent=gene-Rv3825c;Dbxref=EnsemblGenomes-Gn:Rv3825c,EnsemblGenomes-Tr:CCP46654,GOA:P9WQE9,InterPro:IPR001227,InterPro:IPR002198,InterPro:IPR006162,InterPro:IPR009081,InterPro:IPR011032,InterPro:IPR013149,InterPro:IPR013154,InterPro:IPR014030,InterPro:IPR014031,InterPro:IPR014043,InterPro:IPR016035,InterPro:IPR016036,InterPro:IPR016038,InterPro:IPR016039,InterPro:IPR016040,InterPro:IPR018201,InterPro:IPR020801,InterPro:IPR020807,InterPro:IPR020842,InterPro:IPR020843,NCBI_GP:CCP46654.1;Name=CCP46654.1;Note=Rv3825c%2C (MTCY409.05)%2C len: 2126 aa. pks2%2Cpolyketide synthase (see citation below)%2C equivalent to Q9CD78|mas|ML0139 putative mycocerosic synthase from Mycobacterium leprae (2116 aa)%2C FASTA scores: opt: 6828%2CE(): 0%2C (63.3%25 identity in 2128 aa overlap)%3B and Q49624|PKS3|MASA|ML1229|B1170_C2_209 probable mycocerosic acid synthase from Mycobacterium leprae (2118 aa) FASTA scores: opt: 5220%2C E(): 0%2C (62.4%25 identity in 2130 aa overlap)%3B or similar in part to others from Mycobacterium leprae e.g. Q9CB70|ML2354 polyketide synthase (1822 aa) FASTA scores: opt: 2787%2C E(): 2.1e-145%2C (34.7%25 identity in 2135 aa overlap). Also highly similar to Q02251|MCAS_MYCBO|mas mycocerosic acid synthase from Mycobacterium bovis (2110 aa)%2C FASTA scores: opt: 3495%2CE(): 2.6e-184%2C (61.65%25 identity in 2130 aa overlap). Also highly similar to other polyketide synthases from Mycobacterium tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 (2108 aa) FASTA scores: opt: 9576%2C E(): 0%2C (69.8%25 identity in 2124 aa overlap)%3B P96291|mas|Rv2940c|MTCY24G1.09|MTCY19H9.08c (2111 aa)%2C FASTA scores: opt: 3518%2C E(): 1.4e-185%2C (64.05%25 identity in 2126 aa overlap)%3B O50437|PKS4|Rv1181|MTV005.17 (1582 aa)%2C FASTA scores: opt: 3461%2C E(): 1.6e-182%2C (64.55%25 identity in 1609 aa overlap)%3B etc. Contains PS00606 Beta-ketoacyl synthases active site and PS00012 Phosphopantetheine attachment site.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pks2;inference=protein motif:PROSITE:PS00606;locus_tag=Rv3825c;product=Polyketide synthase Pks2;protein_id=CCP46654.1;transl_table=11
AL123456.3	EMBL	gene	4299812	4301566	.	+	.	ID=gene-Rv3826;Name=fadD23;gbkey=Gene;gene=fadD23;gene_biotype=protein_coding;locus_tag=Rv3826
AL123456.3	EMBL	CDS	4299812	4301566	.	+	0	ID=cds-CCP46655.1;Parent=gene-Rv3826;Dbxref=EnsemblGenomes-Gn:Rv3826,EnsemblGenomes-Tr:CCP46655,GOA:P9WQ47,InterPro:IPR000873,NCBI_GP:CCP46655.1;Name=CCP46655.1;Note=Rv3826%2C (MTCY409.04c)%2C len: 584 aa. Probable fadD23%2Cfatty-acid-AMP synthetase%2C highly similar to P71495 acyl-CoA synthase from Mycobacterium bovis (582 aa)%2C FASTA scores: opt: 2571%2C E(): 4.4e-146%2C (66.15%25 identity in 576 aa overlap)%3B Q9CD79|FADD28|ML0138 acyl-CoA synthetase from Mycobacterium leprae (579 aa) FASTA scores: opt: 2520%2C E(): 4.9e-143%2C (65.2%25 identity in 575 aa overlap)%3B P54200|FD21_MYCLE putative fatty-acid--CoA ligase (acyl-CoA synthetase) from Mycobacterium leprae (579 aa)%2C FASTA scores: opt: 2330%2C E(): 1.1e-131%2C (60.2%25 identity in 578 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. P96290|FADD28|Rv2941|MTCY24G1.08c (580 aa)%2C FASTA scores: opt: 2587%2C E(): 4.9e-147%2C (66.5%25 identity in 576 aa overlap)%3B O53903|FADD24|Rv1529|MTV045.03 (584 aa)%2C FASTA scores: opt: 2457%2C E(): 2.9e-139%2C (63.35%25 identity in 584 aa overlap)%3B Q50586|FADD25|Rv1521|MT1572|MTCY19G5.07 (583 aa) FASTA scores: opt: 2389%2C E(): 3.3e-135%2C (61.45%25 identity in 581 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=fadD23;locus_tag=Rv3826;product=Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);protein_id=CCP46655.1;transl_table=11
AL123456.3	EMBL	mobile_genetic_element	4301543	4303415	.	-	.	ID=id-AL123456.3:4301543..4303415;Note=IS1537%2C len: 1873 nt. Insertion sequence IS1537.;gbkey=mobile_element;mobile_element_type=insertion sequence:IS1537
AL123456.3	EMBL	gene	4301563	4302789	.	-	.	ID=gene-Rv3827c;Name=Rv3827c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3827c
AL123456.3	EMBL	CDS	4301563	4302789	.	-	0	ID=cds-CCP46656.1;Parent=gene-Rv3827c;Dbxref=EnsemblGenomes-Gn:Rv3827c,EnsemblGenomes-Tr:CCP46656,GOA:O07796,InterPro:IPR001959,InterPro:IPR021027,UniProtKB/TrEMBL:O07796,NCBI_GP:CCP46656.1;Name=CCP46656.1;Note=Rv3827c%2C (MTCY409.03)%2C len: 408 aa. Possible transposase within IS1537 element%2C similar to several transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|DR1651|DR1933 transposase from Deinococcus radiodurans(408 aa) FASTA scores: opt: 302%2C E(): 3.9e-12%2C (30.75%25 identity in 358 aa overlap)%3B Q9RXX7|DR0178 putative transposase from Deinococcus radiodurans (409 aa)%2C FASTA scores: opt: 297%2CE(): 8.2e-12%2C (31.1%25 identity in 360 aa overlap)%3B P73816|SLR2062 transposase from Synechocystis sp. strain PCC 6803 (400 aa)%2C FASTA scores: opt: 296%2C E(): 9.3e-12%2C(30.05%25 identity in 353 aa overlap)%3B etc. Highly similar to proteins from Mycobacterium tuberculosis e.g. O33333|Rv2791c|MTV002.56c transposase (459 aa) FASTA scores: opt: 2211%2C E(): 9.4e-136%2C (87.75%25 identity in 367 aa overlap)%3B P95117|Rv2978c|MTCY349.09 hypothetical 51.4 KDA protein (459 aa)%2C FASTA scores: opt: 2165%2C E(): 9e-133%2C(85.85%25 identity in 367 aa overlap)%3B Q10809|YS85_MYCTU|Rv2885c|MT2953|MTCY274.16c hypothetical 51.3 KDA protein (460 aa)%2C FASTA scores: opt: 2127%2C E(): 2.6e-130%2C (83.95%25 identity in 368 aa overlap)%3B O0777|Rv0606|MTCY19H5.16c probable transposase (fragment) (247 aa)%2C FASTA scores: opt: 1405%2C E(): 9.3e-84%2C (85.3%25 identity in 238 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3827c;product=Possible transposase;protein_id=CCP46656.1;transl_table=11
AL123456.3	EMBL	gene	4302786	4303397	.	-	.	ID=gene-Rv3828c;Name=Rv3828c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3828c
AL123456.3	EMBL	CDS	4302786	4303397	.	-	0	ID=cds-CCP46657.1;Parent=gene-Rv3828c;Dbxref=EnsemblGenomes-Gn:Rv3828c,EnsemblGenomes-Tr:CCP46657,GOA:O07795,InterPro:IPR006118,InterPro:IPR006119,UniProtKB/TrEMBL:O07795,NCBI_GP:CCP46657.1;Name=CCP46657.1;Note=Rv3828c%2C (MTCY409.02)%2C len: 203 aa. Possible resolvase within IS1537 element%2C similar to others e.g. Q97X40|SSO1915 first ORF in transposon ISC1913 from Sulfolobus solfataricus (213 aa)%2C FASTA scores: opt: 275%2CE(): 1.6e-11%2C (30.6%25 identity in 196 aa overlap)%3B Q9V1M0|PAB2076 resolvase related protein from Pyrococcus abyssi (212 aa)%2C FASTA scores: opt: 254%2C E(): 4.2e-10%2C(29.95%25 identity in 197 aa overlap)%3B Q9RMU7|ORFA putative transposase (belongs to the MerR family of transcriptional regulators) from Helicobacter pylori (Campylobacter pylori) (217 aa)%2C FASTA scores: opt: 243%2C E(): 2.3e-09%2C (31.8%25 identity in 154 aa overlap)%3B etc. Also highly similar to proteins from Mycobacterium tuberculosis e.g. O33334|Rv2792c|MTV002.57c resolvase (193 aa)%2C FASTA scores: opt: 970%2C E(): 1.5e-58%2C (79.25%25 identity in 193 aa overlap)%3B O07773|Rv0605|MTCY19H5.17c putative resolvase (202 aa)%2C FASTA scores: opt: 964%2C E(): 4e-58%2C (76.25%25 identity in 202 aa overlap)%3B P95116|Rv2979c|MTCY349.08 hypothetical 21.4 KDA protein (194 aa)%2C FASTA scores: opt: 895%2C E(): 1.8e-53%2C (74.75%25 identity in 194 aa overlap)%3B Q10831|YS86_MYCTU|Rv2886c|MT2954|MTCY274.17c hypothetical 31.9 KDA protein (295 aa)%2C FASTA scores: opt: 826%2C E(): 1.1e-48%2C (66.2%25 identity in 204 aa overlap) (similarity only at C-terminus)%3B etc. Contains PS00397 Site-specific recombinases active site. Possible helix-turn-helix motif from aa 11-32%2C Score 1305 (+3.63 SD).;gbkey=CDS;inference=protein motif:PROSITE:PS00397;locus_tag=Rv3828c;product=Possible resolvase;protein_id=CCP46657.1;transl_table=11
AL123456.3	EMBL	gene	4303398	4305008	.	-	.	ID=gene-Rv3829c;Name=Rv3829c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3829c
AL123456.3	EMBL	CDS	4303398	4305008	.	-	0	ID=cds-CCP46658.1;Parent=gene-Rv3829c;Dbxref=EnsemblGenomes-Gn:Rv3829c,EnsemblGenomes-Tr:CCP46658,GOA:O07794,UniProtKB/TrEMBL:O07794,NCBI_GP:CCP46658.1;Name=CCP46658.1;Note=Rv3829c%2C (MTCY409.01%2C MTCY01A6.40)%2C len: 536 aa. Probable oxidoreductase dehydrogenase%2C similar to others e.g. Q9A3T1|CC3121 phytoene dehydrogenase-related protein from Caulobacter crescentus (543 aa)%2C FASTA scores: opt: 607%2C E(): 9.2e-28%2C (28.25%25 identity in 552 aa overlap)%3B Q98FP6|MLR3676 phytoene dehydrogenase from Rhizobium loti (Mesorhizobium loti) (521 aa)%2C FASTA scores: opt: 605%2C E(): 1.2e-27%2C (28.2%25 identity in 546 aa overlap)%3B Q97W24|SSO2422 phytoene dehydrogenase related protein from Sulfolobus solfataricus (518 aa)%2C FASTA scores: opt: 388%2C E(): 4.4e-15%2C (27.35%25 identity in 530 aa overlap)%3B Q98BS8|MLL5443 probable dehydrogenase from Rhizobium loti (Mesorhizobium loti) (524 aa)%2C FASTA scores: opt: 374%2C E(): 2.9e-14%2C (24.35%25 identity in aa overlap)%3B etc. Also similar to MTCY493.22c|Rv1432|MTCY493.22c hypothetical 50.5 KDA protein (probable dehydrogenase) from Mycobacterium tuberculosis (25.1%25 identity in 295 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3829c;product=Probable dehydrogenase;protein_id=CCP46658.1;transl_table=11
AL123456.3	EMBL	gene	4305056	4305685	.	-	.	ID=gene-Rv3830c;Name=Rv3830c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3830c
AL123456.3	EMBL	CDS	4305056	4305685	.	-	0	ID=cds-CCP46659.1;Parent=gene-Rv3830c;Dbxref=EnsemblGenomes-Gn:Rv3830c,EnsemblGenomes-Tr:CCP46659,GOA:P96248,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR015893,InterPro:IPR023772,UniProtKB/TrEMBL:P96248,NCBI_GP:CCP46659.1;Name=CCP46659.1;Note=Rv3830c%2C (MTCY01A6.39)%2C len: 209 aa. Probable transcriptional regulator TetR family%2C similar to others e.g. P39885|TCMR_STRGA tetracenomycin C transcriptional repressor from Streptomyces glaucescens (226 aa) FASTA scores: opt: 255%2C E(): 6.1e-10%2C (33.65%25 identity in 202 aa overlap)%3B Q9RDR0|SC4A7.02 putative transcriptional regulator from Streptomyces coelicolor (227 aa) FASTA scores: opt: 230%2C E(): 2.8e-08%2C (30.05%25 identity in 213 aa overlap)%3B Q9EWU3|3SC5B7.06 putative regulatory protein from Streptomyces coelicolor (244 aa)%2C FASTA scores: opt: 221%2CE(): 1.2e-07%2C (32.05%25 identity in 181 aa overlap)%3B Q9AJ68|BUTR putative transcriptional repressor from Streptomyces cinnamonensis (268 aa)%2C FASTA scores: opt: 216%2C E(): 2.7e-07%2C (37.8%25 identity in 119 aa overlap)%3B etc. Contains possible helix-turn-helix motif from aa 33-54%2CScore 1699 (+4.97 SD). Seems to belong to the TetR/AcrR family of transcriptional regulators.;gbkey=CDS;locus_tag=Rv3830c;product=Transcriptional regulatory protein (probably TetR-family);protein_id=CCP46659.1;transl_table=11
AL123456.3	EMBL	gene	4305757	4306239	.	+	.	ID=gene-Rv3831;Name=Rv3831;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3831
AL123456.3	EMBL	CDS	4305757	4306239	.	+	0	ID=cds-CCP46660.1;Parent=gene-Rv3831;Dbxref=EnsemblGenomes-Gn:Rv3831,EnsemblGenomes-Tr:CCP46660,InterPro:IPR021362,UniProtKB/TrEMBL:P96247,NCBI_GP:CCP46660.1;Name=CCP46660.1;Note=Rv3831%2C (MTCY01A6.38c)%2C len: 160 aa. Hypothetical unknown protein.;gbkey=CDS;locus_tag=Rv3831;product=Hypothetical protein;protein_id=CCP46660.1;transl_table=11
AL123456.3	EMBL	gene	4306236	4306811	.	-	.	ID=gene-Rv3832c;Name=Rv3832c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3832c
AL123456.3	EMBL	CDS	4306236	4306811	.	-	0	ID=cds-CCP46661.1;Parent=gene-Rv3832c;Dbxref=EnsemblGenomes-Gn:Rv3832c,EnsemblGenomes-Tr:CCP46661,GOA:P96246,InterPro:IPR013216,InterPro:IPR029063,UniProtKB/TrEMBL:P96246,NCBI_GP:CCP46661.1;Name=CCP46661.1;Note=Rv3832c%2C (MTCY01A6.37)%2C len: 191 aa. Conserved protein%2C similar in part to various proteins e.g. Q9XBC9|CZA382.22c putative rRNA methylase from Amycolatopsis orientalis (259 aa)%2C FASTA scores: opt: 196%2CE(): 1.3e-05%2C (38.2%25 identity in 110 aa overlap)%3B CAC48459|SMB20059 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (259 aa)%2C FASTA scores: opt: 188%2C E(): 4.3e-05%2C (33.8%25 identity in 136 aa overlap)%3B Q98FP8|MLL3672 methyl transferase-like protein from Rhizobium loti (Mesorhizobium loti) (264 aa)%2C FASTA scores: opt: 180%2C E(): 0.00014%2C(32.05%25 identity in 156 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3832c;product=Conserved protein;protein_id=CCP46661.1;transl_table=11
AL123456.3	EMBL	gene	4306867	4307658	.	+	.	ID=gene-Rv3833;Name=Rv3833;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3833
AL123456.3	EMBL	CDS	4306867	4307658	.	+	0	ID=cds-CCP46662.1;Parent=gene-Rv3833;Dbxref=EnsemblGenomes-Gn:Rv3833,EnsemblGenomes-Tr:CCP46662,GOA:P96245,InterPro:IPR009057,InterPro:IPR011051,InterPro:IPR013096,InterPro:IPR014710,InterPro:IPR018060,UniProtKB/TrEMBL:P96245,NCBI_GP:CCP46662.1;Name=CCP46662.1;Note=Rv3833%2C (MTCY01A6.36c)%2C len: 263 aa. Probable transcriptional regulator belonging to araC family%2C similar to others e.g. Q9KYN4|SC9H11.05 putative AraC-family transcriptional regulator from Streptomyces coelicolor (289 aa)%2C FASTA scores: opt: 754%2C E(): 1.2e-42%2C (50.45%25 identity in 232 aa overlap)%3B Q9HXH2|PA3830 probable transcriptional regulator from Pseudomonas aeruginosa (270 aa)%2C FASTA scores: opt: 501%2C E(): 6.2e-26%2C (34.85%25 identity in 238 aa overlap)%3B Q9HX87|PA3927 probable transcriptional regulator from Pseudomonas aeruginosa (262 aa)%2C FASTA scores: opt: 496%2C E(): 1.3e-25%2C (36.45%25 identity in 266 aa overlap)%3B P76241|YEAM_ECOLI|B1790 hypothetical transcriptional regulator from Escherichia coli strain K12 (273 aa) FASTA scores: opt: 388%2C E(): 1.9e-18%2C (30.5%25 identity in 223 aa overlap)%3B etc. Contains probable helix-turn-helix motif from aa 164-185%2C Score 2014 (+6.05 SD). Seems to belong to the AraC/XylS family of transcriptional regulators.;gbkey=CDS;locus_tag=Rv3833;product=Transcriptional regulatory protein (probably AraC-family);protein_id=CCP46662.1;transl_table=11
AL123456.3	EMBL	gene	4307655	4308914	.	-	.	ID=gene-Rv3834c;Name=serS;gbkey=Gene;gene=serS;gene_biotype=protein_coding;locus_tag=Rv3834c
AL123456.3	EMBL	CDS	4307655	4308914	.	-	0	ID=cds-CCP46663.1;Parent=gene-Rv3834c;Dbxref=EnsemblGenomes-Gn:Rv3834c,EnsemblGenomes-Tr:CCP46663,GOA:P9WFT7,InterPro:IPR002314,InterPro:IPR002317,InterPro:IPR006195,InterPro:IPR010978,InterPro:IPR015866,NCBI_GP:CCP46663.1;Name=CCP46663.1;Note=Rv3834c%2C (MTCY01A6.35)%2C len: 419 aa. Probable serS%2Cseryl-tRNA synthetase%2C equivalent to Q9CDC1|SERS|ML0082 putative SERYL-tRNA synthase from Mycobacterium leprae (417 aa)%2C FASTA scores: opt: 2361%2C E(): 8.5e-138%2C (85.8%25 identity in 416 aa overlap). Also highly similar many e.g. Q9ZBX1|SYS_STRCO|SERS|SCD78.28c from Streptomyces coelicolor (425 aa)%2C FASTA scores: opt: 1594%2C E(): 1.2e-90%2C(59.75%25 identity in 425 aa overlap)%3B Q9X199|SYS_THEMA|SERS|TM1379 from Thermotoga maritima (425 aa)%2C FASTA scores: opt: 1083%2C E(): 3.3e-59%2C (43.3%25 identity in 425 aa overlap)%3B P37464|SYS_BACSU|SERS from Bacillus subtilis (425 aa)%2C FASTA scores: opt: 1015%2C E(): 5e-55%2C(39.3%25 identity in 425 aa overlap)%3B etc. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. Belongs to class-II aminoacyl-tRNA synthetase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=serS;inference=protein motif:PROSITE:PS00179;locus_tag=Rv3834c;product=SERYL-tRNA synthetase SerS (serine--tRNA ligase) (SERRS) (serine translase);protein_id=CCP46663.1;transl_table=11
AL123456.3	EMBL	gene	4309047	4310396	.	+	.	ID=gene-Rv3835;Name=Rv3835;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3835
AL123456.3	EMBL	CDS	4309047	4310396	.	+	0	ID=cds-CCP46664.1;Parent=gene-Rv3835;Dbxref=EnsemblGenomes-Gn:Rv3835,EnsemblGenomes-Tr:CCP46664,GOA:P9WKW5,InterPro:IPR026004,NCBI_GP:CCP46664.1;Name=CCP46664.1;Note=Rv3835%2C (MTCY01A6.34c)%2C len: 449 aa. Conserved membrane protein%2C equivalent to Q9CDC2|ML0081 putative membrane protein from Mycobacterium leprae (450 aa)%2C FASTA scores: opt: 2079%2C E(): 1.8e-74%2C (69.35%25 identity in 457 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3835;product=Conserved membrane protein;protein_id=CCP46664.1;transl_table=11
AL123456.3	EMBL	gene	4310401	4310814	.	+	.	ID=gene-Rv3836;Name=Rv3836;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3836
AL123456.3	EMBL	CDS	4310401	4310814	.	+	0	ID=cds-CCP46665.1;Parent=gene-Rv3836;Dbxref=EnsemblGenomes-Gn:Rv3836,EnsemblGenomes-Tr:CCP46665,InterPro:IPR010428,UniProtKB/TrEMBL:P96242,NCBI_GP:CCP46665.1;Name=CCP46665.1;Note=Rv3836%2C (MTCY01A6.33c)%2C len: 137 aa. Conserved hypothetical protein%2C highly similar to Q9RKJ2|SCD25.30 hypothetical 13.1 KDA protein from Streptomyces coelicolor (116 aa)%2C FASTA scores: opt: 395%2C E(): 3.3e-19%2C (54.4%25 identity in 114 aa overlap)%3B and similar to CAC47753|SMC0379 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (144 aa) FASTA scores: opt: 194%2C E(): 6e-06%2C (33.05%25 identity in 109 aa overlap)%3B and Q98E37|MLL4425 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (201 aa)%2C FASTA scores: opt: 184%2C E(): 3.7e-05%2C (29.75%25 identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases%2Czinc-binding region signature.;gbkey=CDS;inference=protein motif:PROSITE:PS00142;locus_tag=Rv3836;product=Conserved hypothetical protein;protein_id=CCP46665.1;transl_table=11
AL123456.3	EMBL	gene	4311009	4311707	.	-	.	ID=gene-Rv3837c;Name=Rv3837c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3837c
AL123456.3	EMBL	CDS	4311009	4311707	.	-	0	ID=cds-CCP46666.1;Parent=gene-Rv3837c;Dbxref=EnsemblGenomes-Gn:Rv3837c,EnsemblGenomes-Tr:CCP46666,InterPro:IPR013078,InterPro:IPR029033,UniProtKB/TrEMBL:P96241,NCBI_GP:CCP46666.1;Name=CCP46666.1;Note=Rv3837c%2C (MTCY01A6.32)%2C len: 232 aa. Probable phosphoglycerate mutase%2C equivalent to Q9CDC3|ML0079 putative phosphoglycerate mutase from Mycobacterium leprae (231 aa)%2C FASTA scores: opt: 1116%2C E(): 7.3e-66%2C (71.55%25 identity in 232 aa overlap). Also similar to others e.g. Q9ZAX0|PGM 2%2C3-PDG dependent phosphoglycerate mutase from Amycolatopsis methanolica (205 aa)%2C FASTA scores: opt: 474%2CE(): 6.4e-24%2C (41.85%25 identity in 203 aa overlap)%3B Q9F3Q7|SC10F4.03 putative isomerase from Streptomyces coelicolor (224 aa) FASTA scores: opt: 349%2C E(): 1e-15%2C(33.2%25 identity in 223 aa overlap)%3B Q9RDL0|SCC123.14c putative phosphoglycerate mutase from Streptomyces coelicolor (223 aa)%2C FASTA scores: opt: 256%2C E(): 1.2e-09%2C(34.0%25 identity in 203 aa overlap)%3B Q9RVD2|DR1097 putative phosphoglycerate mutase from Deinococcus radiodurans (232 aa)%2C FASTA scores: opt: 201%2C E(): 5.1e-06%2C (31.45%25 identity in 175 aa overlap)%3B etc. Also similar to P71724|Rv2419c|MTCY428.28|MTCY253.01 hypothetical 24.2 KDA protein from Mycobacterium tuberculosis (223 aa)%2C FASTA scores: opt: 210%2C E(): 1.3e-06%2C (32.0%25 identity in 172 aa overlap). Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00175;locus_tag=Rv3837c;product=Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase);protein_id=CCP46666.1;transl_table=11
AL123456.3	EMBL	gene	4311704	4312669	.	-	.	ID=gene-Rv3838c;Name=pheA;gbkey=Gene;gene=pheA;gene_biotype=protein_coding;locus_tag=Rv3838c
AL123456.3	EMBL	CDS	4311704	4312669	.	-	0	ID=cds-CCP46667.1;Parent=gene-Rv3838c;Dbxref=EnsemblGenomes-Gn:Rv3838c,EnsemblGenomes-Tr:CCP46667,GOA:P9WIC3,InterPro:IPR001086,InterPro:IPR002912,InterPro:IPR018528,NCBI_GP:CCP46667.1;Name=CCP46667.1;Note=Rv3838c%2C (MTCY01A6.31)%2C len: 321 aa. PheA%2Cprephenate dehydratase (see citation below)%2C equivalent to Q9CDC4|PHEA|ML0078 putative prephenate dehydratase from Mycobacterium leprae (322 aa)%2C FASTA scores: opt: 1690%2CE(): 1.3e-93%2C (84.25%25 identity in 311 aa overlap). Also highly similar to others e.g. P10341|PHEA_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (315 aa)%2C FASTA scores: opt: 843%2C E(): 4e-43%2C (45.8%25 identity in 308 aa overlap)%3B Q9ZBX0|SCD78.29c from Streptomyces coelicolor (310 aa)%2C FASTA scores: opt: 820%2C E(): 9.2e-42%2C(46.45%25 identity in 312 aa overlap)%3B Q44104|PHEA_AMYME|PDT from Amycolatopsis methanolica (304 aa)%2C FASTA scores: opt: 707%2C E(): 4.9e-35%2C (45.7%25 identity in 313 aa overlap)%3B etc. Contains PS00858 Prephenate dehydratase signature 2.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pheA;inference=protein motif:PROSITE:PS00858;locus_tag=Rv3838c;product=Prephenate dehydratase PheA;protein_id=CCP46667.1;transl_table=11
AL123456.3	EMBL	gene	4312765	4313541	.	+	.	ID=gene-Rv3839;Name=Rv3839;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3839
AL123456.3	EMBL	CDS	4312765	4313541	.	+	0	ID=cds-CCP46668.1;Parent=gene-Rv3839;Dbxref=EnsemblGenomes-Gn:Rv3839,EnsemblGenomes-Tr:CCP46668,GOA:P96239,InterPro:IPR012349,UniProtKB/TrEMBL:P96239,NCBI_GP:CCP46668.1;Name=CCP46668.1;Note=Rv3839%2C (MTCY01A6.30c)%2C len: 258 aa. Conserved hypothetical protein%2C similar in part to Q9RD78|SCF43.10cfrom hypothetical 25.8 KDA protein Streptomyces coelicolor (241 aa)%2C FASTA scores: opt: 270%2CE(): 3.2e-10%2C (33.45%25 identity in 272 aa overlap)%3B and O00320|F25451_2 hypothetical protein from Homo sapiens (Human) (339 aa)%2C FASTA scores: opt: 126%2C E(): 0.77%2C(28.75%25 identity in 240 aa overlap).;gbkey=CDS;locus_tag=Rv3839;product=Conserved hypothetical protein;protein_id=CCP46668.1;transl_table=11
AL123456.3	EMBL	gene	4313567	4313980	.	+	.	ID=gene-Rv3840;Name=Rv3840;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3840
AL123456.3	EMBL	CDS	4313567	4313980	.	+	0	ID=cds-CCP46669.1;Parent=gene-Rv3840;Dbxref=EnsemblGenomes-Gn:Rv3840,EnsemblGenomes-Tr:CCP46669,InterPro:IPR004474,UniProtKB/TrEMBL:P96238,NCBI_GP:CCP46669.1;Name=CCP46669.1;Note=Rv3840%2C (MTCY01A6.29c)%2C len: 137 aa. Possible transcriptional regulator%2C highly similar in part to PSR proteins (penicillin binding protein repressors) e.g. Q47828|PSR PSR protein from Enterococcus hirae (293 aa) FASTA scores: opt: 221%2C E(): 2.2e-07%2C (41.65%25 identity in 108 aa overlap)%3B O86213|PSRFM PSRFM protein (fragment) from Enterococcus hirae (171 aa)%2C FASTA scores: opt: 202%2C E(): 2.4e-06%2C (40.75%25 identity in 108 aa overlap)%3B Q47865|PSR penicillin binding protein repressor from Enterococcus hirae (148 aa)%2C FASTA scores: opt: 201%2C E(): 2.5e-06%2C(51.65%25 identity in 60 aa overlap)%3B etc. Also highly similar in part to other transcriptional regulators e.g. BAB57524|MSRR peptide methionine sulfoxide reductase regulator from Staphylococcus aureus subsp. aureus Mu50 (327 aa)%2C FASTA scores: opt: 195%2C E(): 1.2e-05%2C (36.7%25 identity in 109 aa overlap)%3B Q99Q02|MSRR|SA1195 peptide methionine sulfoxide reductase regulator from Staphylococcus aureus subsp. aureus N315%2C and Staphylococcus aureus (327 aa)%2C FASTA scores: opt: 192%2CE(): 1.9e-05%2C (36.7%25 identity in 109 aa overlap)%3B Q9K6Q8|LYTR|BH3670 attenuator for lytabc and LYTR expression from Bacillus halodurans (304 aa)%2C FASTA scores: opt: 171%2C E(): 0.00041%2C (34.5%25 identity in 113 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3840;product=Possible transcriptional regulatory protein;protein_id=CCP46669.1;transl_table=11
AL123456.3	EMBL	gene	4314178	4314723	.	+	.	ID=gene-Rv3841;Name=bfrB;gbkey=Gene;gene=bfrB;gene_biotype=protein_coding;locus_tag=Rv3841
AL123456.3	EMBL	CDS	4314178	4314723	.	+	0	ID=cds-CCP46670.1;Parent=gene-Rv3841;Dbxref=EnsemblGenomes-Gn:Rv3841,EnsemblGenomes-Tr:CCP46670,GOA:P9WNE5,InterPro:IPR001519,InterPro:IPR008331,InterPro:IPR009040,InterPro:IPR009078,InterPro:IPR012347,PDB:3QD8,PDB:3UNO,NCBI_GP:CCP46670.1;Name=CCP46670.1;Note=Rv3841%2C (MTCY01A6.28c)%2C len: 181 aa. bfrB%2Cbacterioferritin%2C similar to other ferritin or hypothetical proteins e.g. O26261|MTH158|RSGA ferritin like protein from Methanothermobacter thermautotrophicus (171 aa)%2C FASTA scores: opt: 277%2C E(): 6.6e-11%2C (30.1%25 identity in 166 aa overlap)%3B Q99SZ3|SA1709 hypothetical protein from Staphylococcus aureus subsp. aureus N315 (166 aa)%2C FASTA scores: opt: 275%2C E(): 8.7e-11%2C (33.35%25 identity in 156 aa overlap)%3B Q9X0L2|TM1128 ferritin from Thermotoga maritima (164 aa)%2C FASTA scores: opt: 247%2C E(): 5.3e-09%2C (25.65%25 identity in 156 aa overlap)%3B Q9KDT7|BH1124 ferritin from Bacillus halodurans (169 aa)%2C FASTA scores: opt: 246%2C E(): 6.3e-09%2C (28.95%25 identity in 152 aa overlap)%3B O29424|AF0834 putative ferritin from Archaeoglobus fulgidu (169 aa)%2CFASTA scores: opt: 246%2C E(): 6.3e-09%2C (28.95%25 identity in 152 aa overlap)%3B etc. Also shows similarity with Rv1876|MTCY180.42|BFRA probable bacterioferritin from Mycobacterium tuberculosis (159 aa). Seems belong to the bacterioferritin family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=bfrB;locus_tag=Rv3841;product=Bacterioferritin BfrB;protein_id=CCP46670.1;transl_table=11
AL123456.3	EMBL	gene	4314738	4315562	.	-	.	ID=gene-Rv3842c;Name=glpQ1;gbkey=Gene;gene=glpQ1;gene_biotype=protein_coding;locus_tag=Rv3842c
AL123456.3	EMBL	CDS	4314738	4315562	.	-	0	ID=cds-CCP46671.1;Parent=gene-Rv3842c;Dbxref=EnsemblGenomes-Gn:Rv3842c,EnsemblGenomes-Tr:CCP46671,GOA:P9WMU3,InterPro:IPR004129,InterPro:IPR017946,NCBI_GP:CCP46671.1;Name=CCP46671.1;Note=Rv3842c%2C (MTCY01A6.27)%2C len: 274 aa. Probable glpQ1%2Cglycerophosphoryl diester phosphodiesterase%2C equivalent to Q9CDC5|GLPQ|ML0074 putative glycerophosphoryl diester phosphodiesterase from Mycobacterium leprae (271 aa)%2C FASTA scores: opt: 1635%2C E(): 1.9e-100%2C (88.85%25 identity in 269 aa overlap). Also highly similar to others e.g. CAC44700|SCBAC25E3.13c putative phosphodiesterase from Streptomyces coelicolor (275 aa)%2C FASTA scores: opt: 413%2CE(): 5.7e-20%2C (48.05%25 identity in 258 aa overlap)%3B P37965|GLPQ_BACSU glycerophosphoryl diester phosphodiesterase from Bacillus subtilis (293 aa)%2C FASTA scores: opt: 405%2C E(): 2e-19%2C (31.3%25 identity in 249 aa overlap)%3B Q99VC9|GLPQ|SA0820 glycerophosphoryl diester phosphodiesterase from Staphylococcus aureus subsp. aureus N315 (309 aa) FASTA scores: opt: 341%2C E(): 3.5e-15%2C (29.3%25 identity in 273 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=glpQ1;locus_tag=Rv3842c;product=Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase);protein_id=CCP46671.1;transl_table=11
AL123456.3	EMBL	gene	4314798	4314891	.	+	.	ID=gene-ncrMT3949;Name=ncrMT3949;gbkey=Gene;gene=ncrMT3949;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	4314798	4314891	.	+	.	ID=rna-ncrMT3949;Parent=gene-ncrMT3949;Note=ncrMT3949%2C fragment of putative small regulatory RNA (See Pelly et al.%2C 2012)%2C cloned from M. tuberculosis CDC1551%3B supported by RNA-seq in H37Rv (unpublished data).;gbkey=ncRNA;gene=ncrMT3949;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	exon	4314798	4314891	.	+	.	ID=exon-ncrMT3949-1;Parent=rna-ncrMT3949;Note=ncrMT3949%2C fragment of putative small regulatory RNA (See Pelly et al.%2C 2012)%2C cloned from M. tuberculosis CDC1551%3B supported by RNA-seq in H37Rv (unpublished data).;gbkey=ncRNA;gene=ncrMT3949;product=Fragment of putative small regulatory RNA
AL123456.3	EMBL	gene	4315568	4316596	.	-	.	ID=gene-Rv3843c;Name=Rv3843c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3843c
AL123456.3	EMBL	CDS	4315568	4316596	.	-	0	ID=cds-CCP46672.1;Parent=gene-Rv3843c;Dbxref=EnsemblGenomes-Gn:Rv3843c,EnsemblGenomes-Tr:CCP46672,GOA:P96235,InterPro:IPR025565,UniProtKB/TrEMBL:P96235,NCBI_GP:CCP46672.1;Name=CCP46672.1;Note=Rv3843c%2C (MTCY01A6.26)%2C len: 342 aa. Probable conserved transmembrane protein%2C equivalent to Q9CDC6|ML0073 putative membrane protein from Mycobacterium leprae (344 aa)%2C FASTA scores: opt: 1420%2C E(): 2.6e-68%2C(63.05%25 identity in 349 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv3843c;product=Probable conserved transmembrane protein;protein_id=CCP46672.1;transl_table=11
AL123456.3	EMBL	gene	4317073	4317165	.	+	.	ID=gene-MTS2975;Name=MTS2975;gbkey=Gene;gene=MTS2975;gene_biotype=ncRNA
AL123456.3	EMBL	ncRNA	4317073	4317165	.	+	.	ID=rna-MTS2975;Parent=gene-MTS2975;Note=MTS2975%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C ends not mapped%2C ~~100 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS2975;product=Putative small regulatory RNA
AL123456.3	EMBL	exon	4317073	4317165	.	+	.	ID=exon-MTS2975-1;Parent=rna-MTS2975;Note=MTS2975%2C putative small regulatory RNA (See Arnvig et al.%2C 2011)%2C ends not mapped%2C ~~100 bp band detected by Northern blot.;gbkey=ncRNA;gene=MTS2975;product=Putative small regulatory RNA
AL123456.3	EMBL	gene	4318775	4319266	.	+	.	ID=gene-Rv3844;Name=Rv3844;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3844
AL123456.3	EMBL	CDS	4318775	4319266	.	+	0	ID=cds-CCP46673.1;Parent=gene-Rv3844;Dbxref=EnsemblGenomes-Gn:Rv3844,EnsemblGenomes-Tr:CCP46673,GOA:P96234,InterPro:IPR002525,UniProtKB/TrEMBL:P96234,NCBI_GP:CCP46673.1;Name=CCP46673.1;Note=Rv3844%2C (MTCY01A6.25)%2C len: 163 aa. Possible transposase%2C identical to P96234|Rv3348|MTV004.04 putative transposase from Mycobacterium tuberculosis. Also some similarity with others e.g. N-terminal part of P19834|YI11_STRCL insertion element IS116 hypothetical 44.8 KDA protein from Streptomyces clavuligerus (399 aa) FASTA scores: opt: 146%2C E(): 0.017%2C (29.1%25 identity in 158 aa overlap).;gbkey=CDS;locus_tag=Rv3844;product=Possible transposase;protein_id=CCP46673.1;transl_table=11
AL123456.3	EMBL	gene	4319281	4319640	.	+	.	ID=gene-Rv3845;Name=Rv3845;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3845
AL123456.3	EMBL	CDS	4319281	4319640	.	+	0	ID=cds-CCP46674.1;Parent=gene-Rv3845;Dbxref=EnsemblGenomes-Gn:Rv3845,EnsemblGenomes-Tr:CCP46674,GOA:P96233,UniProtKB/TrEMBL:P96233,NCBI_GP:CCP46674.1;Name=CCP46674.1;Note=Rv3845%2C (MTCY01A6.24c)%2C len: 119 aa. Hypothetical unknown protein. Contains PS01137 Hypothetical YBL055c/yjjV family signature 1.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS01137;locus_tag=Rv3845;product=Hypothetical protein;protein_id=CCP46674.1;transl_table=11
AL123456.3	EMBL	gene	4320704	4321327	.	+	.	ID=gene-Rv3846;Name=sodA;gbkey=Gene;gene=sodA;gene_biotype=protein_coding;gene_synonym=sod,sodB;locus_tag=Rv3846
AL123456.3	EMBL	CDS	4320704	4321327	.	+	0	ID=cds-CCP46675.1;Parent=gene-Rv3846;Dbxref=EnsemblGenomes-Gn:Rv3846,EnsemblGenomes-Tr:CCP46675,GOA:P9WGE7,InterPro:IPR001189,InterPro:IPR019831,InterPro:IPR019832,InterPro:IPR019833,PDB:1GN2,PDB:1GN3,PDB:1GN4,PDB:1GN6,PDB:1IDS,NCBI_GP:CCP46675.1;Name=CCP46675.1;Note=Rv3846%2C (MTCY01A6.22c)%2C len: 207 aa. SodA (alternate gene names: sodB%2C sod)%2C superoxide dismutase (see citations below)%2C equivalent to many e.g. P47201|SODM_MYCAV|soda|sod from Mycobacterium avium (206 aa)%2C FASTA scores: opt: 1210%2CE(): 1.8e-73%2C (82.5%25 identity in 206 aa overlap)%3B Q9F9R1|sod from Mycobacterium paratuberculosis (207 aa)%2CFASTA scores: opt: 1207%2C E(): 2.9e-73%2C (81.65%25 identity in 207 aa overlap)%3B O86165|SODM_MYCLP|soda|sod from Mycobacterium lepraemurium (206 aa)%2C FASTA scores: opt: 1204%2C E(): 4.5e-73%2C (82.05%25 identity in 206 aa overlap)%3B P13367|SODM_MYCLE|soda|ML0072 from Mycobacterium leprae (206 aa)%2C FASTA scores: opt: 1169%2C E(): 9.6e-71%2C (80.5%25 identity in 205 aa overlap)%3B etc. Contains PS00088 Manganese and iron superoxide dismutases signature. Belongs to the iron/manganese superoxide dismutase family. Although found extracellularly%2C no signal sequence is present. An alternative secretory pathway may be used.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sodA;inference=protein motif:PROSITE:PS00088;locus_tag=Rv3846;product=Superoxide dismutase [FE] SodA;protein_id=CCP46675.1;transl_table=11
AL123456.3	EMBL	gene	4321538	4322071	.	+	.	ID=gene-Rv3847;Name=Rv3847;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3847
AL123456.3	EMBL	CDS	4321538	4322071	.	+	0	ID=cds-CCP46676.1;Parent=gene-Rv3847;Dbxref=EnsemblGenomes-Gn:Rv3847,EnsemblGenomes-Tr:CCP46676,UniProtKB/TrEMBL:P96230,NCBI_GP:CCP46676.1;Name=CCP46676.1;Note=Rv3847%2C (MTCY01A6.21c)%2C len: 177 aa. Conserved hypothetical protein%2C equivalent to Q9CDC7|ML0071 hypothetical protein from Mycobacterium leprae (177 aa) FASTA scores: opt: 1149%2C E(): 1.6e-64%2C (96.6%25 identity in 177 aa overlap)%3B and Q9F9R0 hypothetical 18.5 KDA protein from Mycobacterium paratuberculosis (177 aa)%2C FASTA scores: opt: 1139%2C E(): 6.8e-64%2C (96.6%25 identity in 177 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;gbkey=CDS;locus_tag=Rv3847;product=Hypothetical protein;protein_id=CCP46676.1;transl_table=11
AL123456.3	EMBL	gene	4322326	4323234	.	+	.	ID=gene-Rv3848;Name=Rv3848;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3848
AL123456.3	EMBL	CDS	4322326	4323234	.	+	0	ID=cds-CCP46677.1;Parent=gene-Rv3848;Dbxref=EnsemblGenomes-Gn:Rv3848,EnsemblGenomes-Tr:CCP46677,GOA:P96229,InterPro:IPR001727,UniProtKB/TrEMBL:P96229,NCBI_GP:CCP46677.1;Name=CCP46677.1;Note=Rv3848%2C (MTCY01A6.20c)%2C len: 302 aa. Probable conserved transmembrane protein%2C similar to hypothetical (transmembrane) proteins e.g. Q9HVG2|PA4629 hypothetical protein from Pseudomonas aeruginosa (192 aa)%2C FASTA scores: opt: 304%2C E(): 5.3e-11%2C (35.05%25 identity in 174 aa overlap)%3B Q9A5S7|CC2370 hypothetical protein from Caulobacter crescentus (207 aa)%2C FASTA scores: opt: 285%2CE(): 7.4e-10%2C (29.9%25 identity in 184 aa overlap)%3B Q9KY43|SCC8A.05c putative integral membrane protein from Streptomyces coelicolor (193 aa)%2C FASTA scores: opt: 245%2CE(): 1.6e-07%2C (32.8%25 identity in 195 aa overlap)%3B etc.;gbkey=CDS;locus_tag=Rv3848;product=Probable conserved transmembrane protein;protein_id=CCP46677.1;transl_table=11
AL123456.3	EMBL	gene	4323499	4323897	.	+	.	ID=gene-Rv3849;Name=espR;gbkey=Gene;gene=espR;gene_biotype=protein_coding;locus_tag=Rv3849
AL123456.3	EMBL	CDS	4323499	4323897	.	+	0	ID=cds-CCP46678.1;Parent=gene-Rv3849;Dbxref=EnsemblGenomes-Gn:Rv3849,EnsemblGenomes-Tr:CCP46678,GOA:P9WJB7,InterPro:IPR010982,PDB:3QF3,PDB:3QWG,PDB:3QYX,PDB:3R1F,PDB:4NDW,NCBI_GP:CCP46678.1;Name=CCP46678.1;Note=Rv3849%2C (MTCY01A6.19c)%2C len: 132 aa. EspR%2C ESX-1 secreted protein regulator (See Raghavan et al.%2C 2008)%2Cequivalent to Q9CDC9|ML0069 hypothetical protein from Mycobacterium leprae (132 aa) FASTA scores: opt: 724%2C E(): 8.7e-41%2C (83.95%25 identity in 131 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espR;locus_tag=Rv3849;product=ESX-1 transcriptional regulatory protein EspR;protein_id=CCP46678.1;transl_table=11
AL123456.3	EMBL	gene	4324015	4324671	.	+	.	ID=gene-Rv3850;Name=Rv3850;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3850
AL123456.3	EMBL	CDS	4324015	4324671	.	+	0	ID=cds-CCP46679.1;Parent=gene-Rv3850;Dbxref=EnsemblGenomes-Gn:Rv3850,EnsemblGenomes-Tr:CCP46679,GOA:P96227,UniProtKB/TrEMBL:P96227,NCBI_GP:CCP46679.1;Name=CCP46679.1;Note=Rv3850%2C (MTCY01A6.18c)%2C len: 218 aa. Conserved protein%2C equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071%2CE(): 7.2e-55%2C (78.35%25 identity in 217 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3850;product=Conserved protein;protein_id=CCP46679.1;transl_table=11
AL123456.3	EMBL	gene	4324683	4324967	.	+	.	ID=gene-Rv3851;Name=Rv3851;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3851
AL123456.3	EMBL	CDS	4324683	4324967	.	+	0	ID=cds-CCP46680.1;Parent=gene-Rv3851;Dbxref=EnsemblGenomes-Gn:Rv3851,EnsemblGenomes-Tr:CCP46680,UniProtKB/TrEMBL:P96226,NCBI_GP:CCP46680.1;Name=CCP46680.1;Note=Rv3851%2C (MTCY01A6.17c)%2C len: 94 aa. Possible membrane protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3851;product=Possible membrane protein;protein_id=CCP46680.1;transl_table=11
AL123456.3	EMBL	gene	4325074	4325478	.	+	.	ID=gene-Rv3852;Name=hns;gbkey=Gene;gene=hns;gene_biotype=protein_coding;locus_tag=Rv3852
AL123456.3	EMBL	CDS	4325074	4325478	.	+	0	ID=cds-CCP46681.1;Parent=gene-Rv3852;Dbxref=EnsemblGenomes-Gn:Rv3852,EnsemblGenomes-Tr:CCP46681,UniProtKB/TrEMBL:I6YHB0,NCBI_GP:CCP46681.1;Name=CCP46681.1;Note=Rv3852%2C (MTCY01A6.16c)%2C len: 134 aa. Possible hns%2Chistone-like protein%2C equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa)%2CFASTA scores: opt: 341%2C E(): 4.3e-09%2C (51.5%25 identity in 134 aa overlap). Shows some similarity with other histone-like proteins e.g. O65795|HIS1 histone H1 from Triticum aestivum (Wheat) (288 aa)%2C FASTA scores: opt: 183%2CE(): 0.091%2C (34.85%25 identity in 109 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=hns;locus_tag=Rv3852;product=Possible histone-like protein Hns;protein_id=CCP46681.1;transl_table=11
AL123456.3	EMBL	gene	4325495	4325968	.	+	.	ID=gene-Rv3853;Name=rraA;gbkey=Gene;gene=rraA;gene_biotype=protein_coding;gene_synonym=menG;locus_tag=Rv3853
AL123456.3	EMBL	CDS	4325495	4325968	.	+	0	ID=cds-CCP46682.1;Parent=gene-Rv3853;Dbxref=EnsemblGenomes-Gn:Rv3853,EnsemblGenomes-Tr:CCP46682,GOA:P9WGY3,InterPro:IPR005493,InterPro:IPR010203,PDB:1NXJ,NCBI_GP:CCP46682.1;Name=CCP46682.1;Note=Rv3853%2C (MTCY01A6.15c)%2C len: 157 aa. RraA%2C regulator of RNase E activity A%2C equivalent to Q9CDD2|RRAA|ML0066 rraA%2C regulator of RNase E activity a from Mycobacterium leprae (157 aa) FASTA scores: opt: 896%2C E(): 1.3e-49%2C(87.1%25 identity in 155 aa overlap). Also similar to others e.g. P32165|RRAA_ECOLI|B3929|Z5476|ECS4856 from Escherichia coli strain K12 (161 aa)%2C FASTA scores: opt: 428%2C E(): 3.7e-20%2C (45.65%25 identity in 149 aa overlap)%3B etc. Previously known as menG.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=rraA;locus_tag=Rv3853;product=Regulator of RNase E activity a RraA;protein_id=CCP46682.1;transl_table=11
AL123456.3	EMBL	gene	4326004	4327473	.	-	.	ID=gene-Rv3854c;Name=ethA;gbkey=Gene;gene=ethA;gene_biotype=protein_coding;gene_synonym=aka,etaA;locus_tag=Rv3854c
AL123456.3	EMBL	CDS	4326004	4327473	.	-	0	ID=cds-CCP46683.1;Parent=gene-Rv3854c;Dbxref=EnsemblGenomes-Gn:Rv3854c,EnsemblGenomes-Tr:CCP46683,GOA:P9WNF9,NCBI_GP:CCP46683.1;Name=CCP46683.1;Note=Rv3854c%2C (MTCY01A6.14)%2C len: 489 aa. EthA (alternate gene names: aka%2C etaA)%2C monooxygenase required for activation of the pro-drug ethionamide (see citations below)%2C highly similar to other monooxygenases e.g. Q9A588|CC2569 monooxygenase (flavin-binding family) from Caulobacter crescentus (498 aa)%2C FASTA scores: opt: 1959%2CE(): 2.9e-114%2C (57.6%25 identity in 481 aa overlap)%3B Q9RZT0|DRB0033 arylesterase/monoxygenase from Deinococcus radiodurans (833 aa)%2C FASTA scores: opt: 1771%2C E(): 2.2e-102%2C (53.75%25 identity in 480 aa overlap)%3B Q9A8K5|CC1348 monooxygenase (flavin-binding family) from Caulobacter crescentus (499 aa)%2C FASTA scores: opt: 1385%2CE(): 1.4e-78%2C (43.2%25 identity in 486 aa overlap)%3B etc. Also highly similar to others from Mycobacterium tuberculosis e.g. O53300|Rv3083|MTV013.04 monoxygenase (495 aa) FASTA scores: opt: 1692%2C E(): 1.1e-97%2C (49.7%25 identity in 489 aa overlap)%3B O53762|Rv0565c|MTV039.03c putative monoxygenase (486 aa)%2C FASTA scores: opt: 1571%2C E(): 3.7e-90%2C (49.05%25 identity in 471 aa overlap)%3B O69708|Rv3741c|MTV025.089c possible oxidoreductase (probably second part of a two component monooxygenase) (224 aa)%2C FASTA scores: opt: 542%2CE(): 1.7e-26%2C (50.0%25 identity in 162 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ethA;locus_tag=Rv3854c;product=Monooxygenase EthA;protein_id=CCP46683.1;transl_table=11
AL123456.3	EMBL	gene	4327549	4328199	.	+	.	ID=gene-Rv3855;Name=ethR;gbkey=Gene;gene=ethR;gene_biotype=protein_coding;gene_synonym=aka,etaR;locus_tag=Rv3855
AL123456.3	EMBL	CDS	4327549	4328199	.	+	0	ID=cds-CCP46684.1;Parent=gene-Rv3855;Dbxref=EnsemblGenomes-Gn:Rv3855,EnsemblGenomes-Tr:CCP46684,GOA:P9WMC1,InterPro:IPR001647,InterPro:IPR009057,InterPro:IPR011075,InterPro:IPR015893,PDB:1T56,PDB:1U9N,PDB:1U9O,PDB:3G1L,PDB:3G1M,PDB:3G1O,PDB:3O8G,PDB:3O8H,PDB:3Q0U,PDB:3Q0V,PDB:3Q0W,PDB:3Q3S,PDB:3QPL,PDB:3SDG,PDB:3SFI,PDB:3TP0,PDB:3TP3,PDB:4DW6,PDB:4M3B,PDB:4M3D,PDB:4M3E,PDB:4M3G,NCBI_GP:CCP46684.1;Name=CCP46684.1;Note=Rv3855%2C (MTCY01A6.13c)%2C len: 216 aa. EthR (alternate gene names: aka%2C etaR)%2C regulatory protein TetR family%2Cinvolved in ethionamide sensitivity/resistance%2C negatively controls neighbouring ethA (Rv3854c%2C MTCY01A6.14%3B alternate gene names: aka etaA) (see citations below). Equivalent to Q9CDD3|ML0064 putative transcriptional regulator from Mycobacterium leprae (214 aa)%2C FASTA scores: opt: 1017%2CE(): 7e-62%2C (77.0%25 identity in 213 aa overlap). Also similar to other transcriptional regulator e.g. Q9S1R1|SCJ9A.09 putative TetR-family transcriptional regulator from Streptomyces coelicolor (204 aa)%2C FASTA scores: opt: 305%2C E(): 1.2e-13%2C (34.5%25 identity in 200 aa overlap)%3B Q9KYT9|SCE22.24 putative TetR-family transcriptional regulator (fragment) from Streptomyces coelicolor (244 aa)%2C FASTA scores: opt: 179%2C E(): 4.9e-05%2C(35.5%25 identity in 93 aa overlap)%3B Q9RUK2|DR1384 transcriptional regulator (TetR family) from Deinococcus radiodurans (196 aa)%2C FASTA scores: opt: 167%2C E(): 0.00026%2C(41.75%25 identity in 79 aa overlap)%3B etc. Also similar to P95100|Rv3058c|MTCY22D7.23 hypothetical 23.8 KDA protein from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 261%2C E(): 1.2e-10%2C (31.65%25 identity in 221 aa overlap)%3B and O08377|Rv1534|MTCY07A7A.03 hypothetical 24.5 KDA protein from Mycobacterium tuberculosis (225 aa)%2C FASTA scores: opt: 164%2C E(): 0.00047%2C (25.5%25 identity in 248 aa overlap). Contains helix-turn-helix motif at aa 45-66%2C Score 1320 (+3.68 SD). Belongs to the TetR/AcrR family of transcriptional regulators.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=ethR;locus_tag=Rv3855;product=Transcriptional regulatory repressor protein (TetR-family) EthR;protein_id=CCP46684.1;transl_table=11
AL123456.3	EMBL	gene	4328401	4329408	.	-	.	ID=gene-Rv3856c;Name=Rv3856c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3856c
AL123456.3	EMBL	CDS	4328401	4329408	.	-	0	ID=cds-CCP46685.1;Parent=gene-Rv3856c;Dbxref=EnsemblGenomes-Gn:Rv3856c,EnsemblGenomes-Tr:CCP46685,GOA:P96221,InterPro:IPR003141,InterPro:IPR004013,InterPro:IPR010996,InterPro:IPR016195,InterPro:IPR017078,InterPro:IPR027421,UniProtKB/TrEMBL:P96221,NCBI_GP:CCP46685.1;Name=CCP46685.1;Note=Rv3856c%2C (MTCY01A6.12)%2C len: 335 aa. Conserved hypothetical protein%2C highly similar to various proteins from diverse organisms e.g. Q9EWR3|3SCF60.21 conserved hypothetical protein from Streptomyces coelicolor (372 aa) FASTA scores: opt: 1286%2C E(): 2.4e-73%2C (64.0%25 identity in 336 aa overlap)%3B P72464|ORF1 from Streptomyces lividans (343 aa)%2C FASTA scores: opt: 1275%2C E(): 1.1e-72%2C (60.1%25 identity in 336 aa overlap)%3B Q9K899|BH3107 DNA-dependent DNA polymerase beta chain from Bacillus halodurans (571 aa)%2C FASTA scores: opt: 592%2C E(): 1.2e-29%2C (39.15%25 identity in 240 aa overlap)%3B etc. May be a DNA polymerase beta (gene name: yshC) (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3856c;product=Conserved hypothetical protein;protein_id=CCP46685.1;transl_table=11
AL123456.3	EMBL	gene	4329417	4329614	.	-	.	ID=gene-Rv3857c;Name=Rv3857c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3857c
AL123456.3	EMBL	CDS	4329417	4329614	.	-	0	ID=cds-CCP46686.1;Parent=gene-Rv3857c;Dbxref=EnsemblGenomes-Gn:Rv3857c,EnsemblGenomes-Tr:CCP46686,UniProtKB/TrEMBL:P96220,NCBI_GP:CCP46686.1;Name=CCP46686.1;Note=Rv3857c%2C (MTCY01A6.11)%2C len: 65 aa. Possible membrane protein.;gbkey=CDS;locus_tag=Rv3857c;product=Possible membrane protein;protein_id=CCP46686.1;transl_table=11
AL123456.3	EMBL	gene	4330039	4331505	.	-	.	ID=gene-Rv3858c;Name=gltD;gbkey=Gene;gene=gltD;gene_biotype=protein_coding;locus_tag=Rv3858c
AL123456.3	EMBL	CDS	4330039	4331505	.	-	0	ID=cds-CCP46687.1;Parent=gene-Rv3858c;Dbxref=EnsemblGenomes-Gn:Rv3858c,EnsemblGenomes-Tr:CCP46687,GOA:P9WN19,InterPro:IPR001327,InterPro:IPR006005,InterPro:IPR009051,InterPro:IPR016040,InterPro:IPR023753,InterPro:IPR028261,NCBI_GP:CCP46687.1;Name=CCP46687.1;Note=Rv3858c%2C (MTCY01A6.10)%2C len: 488 aa. Probable gltD%2Csmall subunit of NADH-dependent glutamate synthase%2Cequivalent to Q9CDD4|GLTD|ML0062 NADH-dependent glutamate synthase small subunit from Mycobacterium leprae (488 aa)%2CFASTA scores: opt: 2997%2C E(): 1e-166%2C (87.7%25 identity in 488 aa overlap). Also highly similar to many e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487 aa)%2CFASTA scores: opt: 2152%2C E(): 1.2e-117%2C (63.85%25 identity in 487 aa overlap)%3B Q9KPJ3|VC2374 from Vibrio cholerae (489 aa)%2C FASTA scores: opt: 1699%2C E(): 2.5e-91%2C (51.75%25 identity in 487 aa overlap)%3B Q03460|GLSN_MEDSA from Medicago sativa (Alfalfa) (2194 aa)%2C FASTA scores: opt: 1322%2C E(): 6.2e-69%2C (54.45%25 identity in 485 aa overlap)%3B P09832|GLTD_ECOLI from strain (471 aa) FASTA scores: opt: 889%2C E() : 0%2C (37.4%25 identity in 473 aa overlap)%3B etc. Similar to other glutamate synthases. Cofactor: FAD (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gltD;locus_tag=Rv3858c;product=Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH)) (GLTS beta chain) (NADPH-GOGAT);protein_id=CCP46687.1;transl_table=11
AL123456.3	EMBL	gene	4331498	4336081	.	-	.	ID=gene-Rv3859c;Name=gltB;gbkey=Gene;gene=gltB;gene_biotype=protein_coding;locus_tag=Rv3859c
AL123456.3	EMBL	CDS	4331498	4336081	.	-	0	ID=cds-CCP46688.1;Parent=gene-Rv3859c;Dbxref=EnsemblGenomes-Gn:Rv3859c,EnsemblGenomes-Tr:CCP46688,GOA:P96218,InterPro:IPR000583,InterPro:IPR002489,InterPro:IPR002932,InterPro:IPR006982,InterPro:IPR013785,InterPro:IPR017932,InterPro:IPR029055,NCBI_GP:CCP46688.1;Name=CCP46688.1;Note=Rv3859c%2C (MTCY01A6.09)%2C len: 1527 aa. Probable gltB%2Cferredoxin-dependent glutamate synthase large subunit%2Cequivalent to Q9CDD5|GLTB|ML0061 putative ferredoxin-dependent glutamate synthase from Mycobacterium leprae (1527 aa)%2C FASTA scores: opt: 9277%2C E(): 0%2C (90.25%25 identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa)%2C FASTA scores: opt: 5939%2C E(): 0%2C (64.3%25 identity in 1544 aa overlap)%3B Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa)%2C FASTA scores: opt: 5790%2C E(): 0%2C (63.25%25 identity in 1534 aa overlap)%3B P39812|GLTB_BACSU|GLTA from Bacillus subtilis (1520 aa)%2CFASTA scores: opt: 3445%2C E(): 2.8e-196%2C (52.25%25 identity in 1531 aa overlap)%3B etc. Similar to other glutamate synthases.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gltB;locus_tag=Rv3859c;product=Probable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH))(NADPH-GOGAT);protein_id=CCP46688.1;transl_table=11
AL123456.3	EMBL	gene	4336777	4337949	.	+	.	ID=gene-Rv3860;Name=Rv3860;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3860
AL123456.3	EMBL	CDS	4336777	4337949	.	+	0	ID=cds-CCP46689.1;Parent=gene-Rv3860;Dbxref=EnsemblGenomes-Gn:Rv3860,EnsemblGenomes-Tr:CCP46689,GOA:P96217,InterPro:IPR025669,InterPro:IPR027417,UniProtKB/TrEMBL:P96217,NCBI_GP:CCP46689.1;Name=CCP46689.1;Note=Rv3860%2C (MTCY01A6.08c)%2C len: 390 aa. Conserved protein%2C showing similarity with hypothetical proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 (586 aa)%2C FASTA scores: opt: 484%2C E(): 5.5e-14%2C (29.95%25 identity in 407 aa overlap)%3B O33082|MLCB628.11c (478 aa) FASTA scores: opt: 484%2C E(): 4.8e-14%2C (29.95%25 identity in 407 aa overlap)%3B etc. Also some similarity with O86637|SC3C3.03c hypothetical 112.1 KDA protein from Streptomyces coelicolor(1083 aa)%2C FASTA scores: opt: 483%2C E(): 9.6e-14%2C(30.45%25 identity in 404 aa overlap). And some similarity with other proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O05456|Rv3888c|MTCY15F10.24 hypothetical 37.7 KDA protein (341 aa)%2C FASTA scores: opt: 603%2C E(): 2.8e-19%2C (35.2%25 identity in 284 aa overlap)%3B O06396|Rv0530|MTCY25D10.09 hypothetical 43.0 KDA protein (405 aa)%2C FASTA scores: opt: 538%2C E(): 2e-16%2C (31.0%25 identity in 371 aa overlap)%3B O69740|Rv3876|MTV027.11 (666 aa)%2C FASTA scores: opt: 475%2CE(): 1.5e-13%2C (30.2%25 identity in 391 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3860;product=Conserved protein;protein_id=CCP46689.1;transl_table=11
AL123456.3	EMBL	gene	4337946	4338272	.	+	.	ID=gene-Rv3861;Name=Rv3861;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3861
AL123456.3	EMBL	CDS	4337946	4338272	.	+	0	ID=cds-CCP46690.1;Parent=gene-Rv3861;Dbxref=EnsemblGenomes-Gn:Rv3861,EnsemblGenomes-Tr:CCP46690,UniProtKB/TrEMBL:P96216,NCBI_GP:CCP46690.1;Name=CCP46690.1;Note=Rv3861%2C (MTCY01A6.07c)%2C len: 108 aa. Hypothetical unknown protein. Overlaps in part next ORF Rv3862c|whiB6.;gbkey=CDS;locus_tag=Rv3861;product=Hypothetical protein;protein_id=CCP46690.1;transl_table=11
AL123456.3	EMBL	gene	4338171	4338521	.	-	.	ID=gene-Rv3862c;Name=whiB6;gbkey=Gene;gene=whiB6;gene_biotype=protein_coding;gene_synonym=whmF;locus_tag=Rv3862c
AL123456.3	EMBL	CDS	4338171	4338521	.	-	0	ID=cds-CCP46691.1;Parent=gene-Rv3862c;Dbxref=EnsemblGenomes-Gn:Rv3862c,EnsemblGenomes-Tr:CCP46691,GOA:P9WF37,InterPro:IPR003482,NCBI_GP:CCP46691.1;Name=CCP46691.1;Note=Rv3862c%2C (MTCY01A6.06)%2C len: 116 aa. Possible whiB6 (alternate gene name: whmF)%2C WhiB-like regulatory protein (see citation below)%2C similar to WhiB paralogue of Streptomyces coelicolor%2C wblE gene product (85 aa). Shows similarity with Q49765|WHIB7|ML0639|B1937_F2_68 putative transcriptional regulator WHIB7 from Mycobacterium leprae (89 aa) FASTA scores: opt: 112%2C E(): 0.49%2C (41.2%25 identity in 51 aa overlap). Some similarity to Q9AD55|SCP1.95 putative regulatory protein from Streptomyces coelicolor (102 aa) FASTA scores: opt: 129%2C E(): 0.038%2C (32.95%25 identity in 85 aa overlap)%3B AAK47632|MT3290.1 conserved hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (96 aa)%2C FASTA scores: opt: 126%2C E(): 0.058%2C(33.35%25 identity in 84 aa overlap)%3B Q9FC80|SC4B10.07 conserved hypothetical protein from Streptomyces coelicolor (88 aa)%2C FASTA scores: opt: 119%2C E(): 0.16%2C (44.65%25 identity in 70 aa overlap)%3B Q9K4K8|SC5F8.16c regulatory protein from Streptomyces coelicolor (83 aa)%2C FASTA scores: opt: 114%2C E(): 0.34%2C (37.05%25 identity in 54 aa overlap)%3B etc.;gbkey=CDS;gene=whiB6;locus_tag=Rv3862c;product=Possible transcriptional regulatory protein WhiB-like WhiB6;protein_id=CCP46691.1;transl_table=11
AL123456.3	EMBL	gene	4338849	4340027	.	+	.	ID=gene-Rv3863;Name=Rv3863;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3863
AL123456.3	EMBL	CDS	4338849	4340027	.	+	0	ID=cds-CCP46692.1;Parent=gene-Rv3863;Dbxref=EnsemblGenomes-Gn:Rv3863,EnsemblGenomes-Tr:CCP46692,GOA:P96214,InterPro:IPR008984,UniProtKB/TrEMBL:P96214,NCBI_GP:CCP46692.1;Name=CCP46692.1;Note=Rv3863%2C (MTCY01A6.05c)%2C len: 392 aa. Unknown ala-rich protein.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3863;product=Unknown alanine rich protein;protein_id=CCP46692.1;transl_table=11
AL123456.3	EMBL	gene	4340270	4341478	.	+	.	ID=gene-Rv3864;Name=espE;gbkey=Gene;gene=espE;gene_biotype=protein_coding;locus_tag=Rv3864
AL123456.3	EMBL	CDS	4340270	4341478	.	+	0	ID=cds-CCP46693.1;Parent=gene-Rv3864;Dbxref=EnsemblGenomes-Gn:Rv3864,EnsemblGenomes-Tr:CCP46693,GOA:P9WJD3,NCBI_GP:CCP46693.1;Name=CCP46693.1;Note=Rv3864%2C (MTCY01A6.04c)%2C len: 402 aa. EspE%2C ESX-1 secretion-associated protein%2C similar to Q49722|ML0405|B1620_C2_213|MLCL383.01 hypothetical 40.8 KDA protein from Mycobacterium leprae (394 aa) FASTA scores: opt: 397%2C E(): 1.2e-12%2C (31.0%25 identity in 410 aa overlap). Also similar to various proteins from several organisms e.g. Q9VYF9|CG12723 hypothetical protein from Drosophila melanogaster (Fruit fly) (450 aa)%2C FASTA scores: opt: 291%2CE(): 2.3e-07%2C (34.6%25 identity in 130 aa overlap)%3B Q98UE3 procollagen ALPHA1(III) (fragment) from Xenopus laevis (African clawed frog) (117 aa) FASTA scores: opt: 257%2C E(): 3.6e-06%2C (41.75%25 identity in 103 aa overlap)%3B P27393|CA24_ASCSU collagen alpha 2(IV) chain precursor from Ascaris suum (Pig roundworm) (Ascaris lumbricoides) (1763 aa)%2C FASTA scores: opt: 273%2C E(): 5.7e-06%2C (32.1%25 identity in 240 aa overlap)%3B etc. Also similar to O06267|Rv3616c|MTCY07H7B.06 (392 aa) FASTA scores: opt: 389%2C E(): 3e-12%2C (31.6%25 identity in 399 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espE;locus_tag=Rv3864;product=ESX-1 secretion-associated protein EspE;protein_id=CCP46693.1;transl_table=11
AL123456.3	EMBL	gene	4341566	4341877	.	+	.	ID=gene-Rv3865;Name=espF;gbkey=Gene;gene=espF;gene_biotype=protein_coding;locus_tag=Rv3865
AL123456.3	EMBL	CDS	4341566	4341877	.	+	0	ID=cds-CCP46694.1;Parent=gene-Rv3865;Dbxref=EnsemblGenomes-Gn:Rv3865,EnsemblGenomes-Tr:CCP46694,GOA:P9WJD1,InterPro:IPR022536,NCBI_GP:CCP46694.1;Name=CCP46694.1;Note=Rv3865%2C (MTCY01A6.03c)%2C len: 103 aa. EspF%2C ESX-1 secretion-associated protein%2C showing some similarity to O06268|Rv3615c|MTCY07H7B.07 hypothetical 10.8 KDA protein from Mycobacterium tuberculosis (103 aa)%2C FASTA scores: opt: 198%2C E(): 7.5e-07%2C (36.25%25 identity in 102 aa overlap)%3B Q49723|ML0406|B1620_C2_214|MLCL383.02 hypothetical 11.1 KDA protein from Mycobacterium leprae (106 aa)%2C FASTA scores: opt: 154%2C E(): 0.00071%2C (31.05%25 identity in 103 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espF;locus_tag=Rv3865;product=ESX-1 secretion-associated protein EspF;protein_id=CCP46694.1;transl_table=11
AL123456.3	EMBL	gene	4341880	4342731	.	+	.	ID=gene-Rv3866;Name=espG1;gbkey=Gene;gene=espG1;gene_biotype=protein_coding;gene_synonym=snm5;locus_tag=Rv3866
AL123456.3	EMBL	CDS	4341880	4342731	.	+	0	ID=cds-CCP46695.1;Parent=gene-Rv3866;Dbxref=EnsemblGenomes-Gn:Rv3866,EnsemblGenomes-Tr:CCP46695,GOA:P96210,InterPro:IPR025734,NCBI_GP:CCP46695.1;Name=CCP46695.1;Note=Rv3866%2C (MTCY01A6.01c%2C MTV027.01)%2C len: 283 aa. espG1%2C ESX-1 secretion-associated protein. N-terminal end highly similar to O33091|MLCB628.20c hypothetical 13.1 KDA protein from Mycobacterium leprae (122 aa)%2C FASTA scores: opt: 260%2C E(): 2.1e-09%2C (43.6%25 identity in 117 aa overlap)%3B and C-terminal end highly similar to O33090|MLCB628.19c hypothetical 36.7 KDA protein from Mycobacterium leprae (338 aa)%2C FASTA scores: opt: 540%2C E(): 1.4e-26%2C (54.5%25 identity in 156 aa overlap). Also similar to Q9CD34|ML2530 possible DNA-binding protein from Mycobacterium leprae (289 aa)%2C FASTA scores: opt: 146%2C E(): 0.058%2C (28.25%25 identity in 269 aa overlap) and O53694|Rv0289|MTV035.17 hypothetical 31.6 KDA protein from Mycobacterium tuberculosis (295 aa)%2CFASTA scores: opt: 133%2C E(): 0.39%2C (28.15%25 identity in 277 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espG1;locus_tag=Rv3866;product=ESX-1 secretion-associated protein EspG1;protein_id=CCP46695.1;transl_table=11
AL123456.3	EMBL	gene	4342770	4343321	.	+	.	ID=gene-Rv3867;Name=espH;gbkey=Gene;gene=espH;gene_biotype=protein_coding;locus_tag=Rv3867
AL123456.3	EMBL	CDS	4342770	4343321	.	+	0	ID=cds-CCP46696.1;Parent=gene-Rv3867;Dbxref=EnsemblGenomes-Gn:Rv3867,EnsemblGenomes-Tr:CCP46696,GOA:O69732,NCBI_GP:CCP46696.1;Name=CCP46696.1;Note=Rv3867%2C (MTV027.02)%2C len: 183 aa. EspH%2C ESX-1 secretion-associated protein%2C highly similar to the hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403%2C E(): 1.8e-18%2C (48.2%25 identity in 166 aa overlap)%3B Q49730|ML0407|B1620_C3_264|MLCL383.03 (216 aa)%2C FASTA scores: opt: 517%2C E(): 1.7e-25%2C (51.45%25 identity in 175 aa overlap)%3B and O33090|MLCB628.19c (338 aa)%2C FASTA scores: opt: 403%2C E(): 3.4e-18%2C (48.2%25 identity in 166 aa overlap). Also highly similar to O06269|Rv3614c|MTCY07H7B.08 hypothetical 19.8 KDA protein from Mycobacterium tuberculosis (184 aa)%2C FASTA scores: opt: 559%2C E(): 3.4e-28%2C (54.35%25 identity in 173 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espH;locus_tag=Rv3867;product=ESX-1 secretion-associated protein EspH;protein_id=CCP46696.1;transl_table=11
AL123456.3	EMBL	gene	4343314	4345035	.	+	.	ID=gene-Rv3868;Name=eccA1;gbkey=Gene;gene=eccA1;gene_biotype=protein_coding;locus_tag=Rv3868
AL123456.3	EMBL	CDS	4343314	4345035	.	+	0	ID=cds-CCP46697.1;Parent=gene-Rv3868;Dbxref=EnsemblGenomes-Gn:Rv3868,EnsemblGenomes-Tr:CCP46697,GOA:P9WPH9,InterPro:IPR000641,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR023835,InterPro:IPR027417,PDB:4F3V,NCBI_GP:CCP46697.1;Name=CCP46697.1;Note=Rv3868%2C (MTV027.03)%2C len: 573 aa. EccA1%2C esx conserved component%2C ESX-1 type VII secretion system protein. Member of the CbxX/CfqX family of hypothetical proteins%3B C-terminal end is highly similar to many e.g. P40118|CBXC_ALCEU|CBXXC|CFXXC CbxX protein (317 aa) FASTA scores: opt: 572%2C E(): 3e-24%2C (42.7%25 identity in 294 aa overlap)%3B CAC48589 probable CBBX protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB (311 aa) FASTA scores: opt: 569%2C E(): 4.3e-24%2C (40.05%25 identity in 292 aa overlap)%3B P95648|CBBX_RHOSH CBBX protein from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (309 aa)%2C FASTA scores: opt: 559%2C E(): 1.5e-23%2C (41.4%25 identity in 290 aa overlap)%3B etc. Equivalent to O33089|Y2G8_MYCLE|ML0055|MLCB628.18c hypothetical 62.3 KDA protein from Mycobacterium leprae (573 aa)%2C FASTA scores: opt: 3330%2C E(): 3.9e-175%2C (89.2%25 identity in 573 aa overlap)%3B and similar to Q9CD28|Y282_MYCLE|ML2537 hypothetical 69.1 KDA protein from Mycobacterium leprae (640 aa)%2C FASTA scores: opt: 943%2C E(): 2.4e-44%2C (37.5%25 identity in 571 aa overlap). Also similar to many proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 hypothetical 68.1 KDA protein (631 aa)%2C FASTA scores: opt: 936%2C E(): 5.8e-44%2C (39.05%25 identity in 568 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccA1;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3868;product=ESX conserved component EccA1. ESX-1 type VII secretion system protein.;protein_id=CCP46697.1;transl_table=11
AL123456.3	EMBL	gene	4345039	4346481	.	+	.	ID=gene-Rv3869;Name=eccB1;gbkey=Gene;gene=eccB1;gene_biotype=protein_coding;gene_synonym=snm6;locus_tag=Rv3869
AL123456.3	EMBL	CDS	4345039	4346481	.	+	0	ID=cds-CCP46698.1;Parent=gene-Rv3869;Dbxref=EnsemblGenomes-Gn:Rv3869,EnsemblGenomes-Tr:CCP46698,GOA:P9WNR7,InterPro:IPR007795,NCBI_GP:CCP46698.1;Name=CCP46698.1;Note=Rv3869%2C (MTV027.04)%2C len: 480 aa. EccB1%2C esx conserved component%2C ESX-1 type VII secretion system protein%2C possible membrane protein (has hydrophobic stretch near N-terminus)%2C equivalent to O33088|ML0054|MLCB628.17c putative membrane protein from Mycobacterium leprae (481 aa)%2C FASTA scores: opt: 2489%2C E(): 8.3e-136%2C (75.75%25 identity in 478 aa overlap)%3B and similar to others e.g. Q9Z5I3|ML1544|MLCB596.27 conserved membrane protein from Mycobacterium leprae (506 aa)%2C FASTA scores: opt: 739%2C E(): 3.9e-35%2C (33.65%25 identity in 490 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis e.g. O05449|Rv3895c|MTCY15F10.17 (495 aa)%2C FASTA scores: opt: 795%2C E(): 2.3e-38%2C (35.8%25 identity in 486 aa overlap)%3B O53933|Rv1782|MTV049.04 (506 aa)%2C FASTA scores: opt: 763%2CE(): 1.6e-36%2C (34.7%25 identity in 490 aa overlap)%3B O06317|Rv3450c|MTCY13E12.03c (470 aa) FASTA scores: opt: 717%2C E(): 6.7e-34%2C (32.55%25 identity in 479 aa overlap)%3B etc. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccB1;locus_tag=Rv3869;product=ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein.;protein_id=CCP46698.1;transl_table=11
AL123456.3	EMBL	gene	4346481	4348724	.	+	.	ID=gene-Rv3870;Name=eccCa1;gbkey=Gene;gene=eccCa1;gene_biotype=protein_coding;gene_synonym=snm1;locus_tag=Rv3870
AL123456.3	EMBL	CDS	4346481	4348724	.	+	0	ID=cds-CCP46699.1;Parent=gene-Rv3870;Dbxref=EnsemblGenomes-Gn:Rv3870,EnsemblGenomes-Tr:CCP46699,GOA:P9WNB3,InterPro:IPR002543,InterPro:IPR023836,InterPro:IPR027417,NCBI_GP:CCP46699.1;Name=CCP46699.1;Note=Rv3870%2C (MTV027.05)%2C len: 747 aa. EccCa1%2C esx conserved component%2C ESX-1 type VII secretion system protein%2C possible transmembrane protein%2C equivalent to O33087|ML0053|MLCB628.16c putative membrane protein from Mycobacterium leprae (744 aa)%2C FASTA scores: opt: 4333%2CE(): 0%2C (85.4%25 identity in 746 aa overlap)%3B and similar to N-terminal end of others e.g. Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa)%2C FASTA scores: opt: 1003%2C E(): 1e-52%2C (33.65%25 identity in 725 aa overlap)%3B O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa)%2C FASTA scores: opt: 1078%2C E(): 3e-57%2C(35.4%25 identity in 774 aa overlap)%3B P71068|YUKA YUKA protein from Bacillus subtilis (1207 aa) FASTA scores: opt: 529%2C E(): 4.3e-24%2C (26.1%25 identity in 636 aa overlap)%3B Q9KE81|BH0975 hypothetical protein from Bacillus halodurans (1489 aa)%2C FASTA scores: opt: 455%2C E(): 1.5e-19%2C (27.1%25 identity in 734 aa overlap)%3B etc. Also similar to N-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa)%2C FASTA scores: opt: 982%2C E(): 1.9e-51%2C (33.8%25 identity in 719 aa overlap)%3B O06264|Rv3447c|MTCY77.19c (1236 aa)%2C FASTA scores: opt: 761%2C E(): 4.1e-38%2C (38.2%25 identity in 746 aa overlap)%3B O53935|Rv1784|MTV049.06 (932 aa)%2C FASTA scores: opt: 547%2C E(): 2.8e-25%2C (36.25%25 identity in 276 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in downstream ORF MTV027.06.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccCa1;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3870;product=ESX conserved component EccCa1. ESX-1 type VII secretion system protein. Possible transmembrane protein.;protein_id=CCP46699.1;transl_table=11
AL123456.3	EMBL	repeat_region	4348721	4348773	.	+	.	ID=id-AL123456.3:4348721..4348773;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	repeat_region	4348774	4348826	.	+	.	ID=id-AL123456.3:4348774..4348826;Note=53 bp Mycobacterial Interspersed Repetitive Unit%2CClass II;gbkey=repeat_region
AL123456.3	EMBL	gene	4348827	4350602	.	+	.	ID=gene-Rv3871;Name=eccCb1;gbkey=Gene;gene=eccCb1;gene_biotype=protein_coding;gene_synonym=snm2;locus_tag=Rv3871
AL123456.3	EMBL	CDS	4348827	4350602	.	+	0	ID=cds-CCP46700.1;Parent=gene-Rv3871;Dbxref=EnsemblGenomes-Gn:Rv3871,EnsemblGenomes-Tr:CCP46700,GOA:P9WNB1,InterPro:IPR002543,InterPro:IPR003593,InterPro:IPR023837,InterPro:IPR027417,NCBI_GP:CCP46700.1;Name=CCP46700.1;Note=Rv3871%2C (MTV027.06)%2C len: 591 aa. EccCb1%2C esx conserved component%2C ESX-1 type VII secretion system protein%2C equivalent to Q9CDD7|ML0052 hypothetical protein from Mycobacterium leprae (597 aa) FASTA scores: opt: 3341%2CE(): 9.8e-192%2C (80.85%25 identity in 596 aa overlap)%3B and O33086|MLCB628.15c hypothetical protein from Mycobacterium leprae (597 aa)%2C FASTA scores: opt: 3329%2C E(): 5.1e-191%2C(80.55%25 identity in 596 aa overlap). And similar to C-terminal end of others e.g. Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane protein from Mycobacterium leprae (1345 aa)%2C FASTA scores: opt: 601%2C E(): 5.6e-28%2C(32.3%25 identity in 613 aa overlap)%3B O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa)%2C FASTA scores: opt: 977%2C E(): 2.1e-50%2C (35.15%25 identity in 583 aa overlap)%3B Q9L0T6|SCD35.15c putative cell division-related protein from Streptomyces coelicolor (1525 aa)%2C FASTA scores: opt: 414%2C E(): 9e-17%2C (27.6%25 identity in 424 aa overlap)%3BP71068|YUKA YUKA protein from Bacillus subtilis (1207 aa)%2C FASTA scores: opt: 343%2C E(): 1.3e-12%2C(25.8%25 identity in 395 aa overlap)%3B etc. And similar to to C-terminal end of hypothetical proteins from Mycobacterium tuberculosis e.g. O06264|Rv3447c|MTCY77.19c (1236 aa) FASTA scores: opt: 845%2C E(): 1.5e-42%2C (35.3%25 identity in 586 aa overlap)%3B O53689|Rv0284|MTV035.12 (1330 aa) FASTA scores: opt: 646%2C E(): 1.2e-30%2C (33.35%25 identity in 606 aa overlap)%3B O53935|Rv1784|MTV049.06 (932 aa) FASTA scores: opt: 589%2C E(): 2.1e-27%2C (33.1%25 identity in 619 aa overlap)%3B etc. Contains 2 X PS00017 ATP/GTP-binding site motif A (P-loop). Note some similarity (with hypothetical proteins from Mycobacterium tuberculosis and P71068|YUKA) continues in upstream ORF MTV027.05.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccCb1;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3871;product=ESX conserved component EccCb1. ESX-1 type VII secretion system protein.;protein_id=CCP46700.1;transl_table=11
AL123456.3	EMBL	gene	4350745	4351044	.	+	.	ID=gene-Rv3872;Name=PE35;gbkey=Gene;gene=PE35;gene_biotype=protein_coding;locus_tag=Rv3872
AL123456.3	EMBL	CDS	4350745	4351044	.	+	0	ID=cds-CCP46701.1;Parent=gene-Rv3872;Dbxref=EnsemblGenomes-Gn:Rv3872,EnsemblGenomes-Tr:CCP46701,GOA:P9WIG7,InterPro:IPR000084,NCBI_GP:CCP46701.1;Name=CCP46701.1;Note=Rv3872%2C (MTV027.07)%2C len: 99 aa. PE35%2C Some similarity to Mycobacterium tuberculosis conserved PE family proteins (see Brennan %26 Delogu 2002)%2C e.g. O69713|Rv3746c|MTV025.094c (111 aa)%2C FASTA scores: opt: 306%2C E(): 5.5e-13%2C (50.5%25 identity in 99 aa overlap). Equivalent to AAK48354 from Mycobacterium tuberculosis strain CDC1551 (112 aa) but shorter 14 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PE35;locus_tag=Rv3872;product=PE family-related protein PE35;protein_id=CCP46701.1;transl_table=11
AL123456.3	EMBL	gene	4351075	4352181	.	+	.	ID=gene-Rv3873;Name=PPE68;gbkey=Gene;gene=PPE68;gene_biotype=protein_coding;locus_tag=Rv3873
AL123456.3	EMBL	CDS	4351075	4352181	.	+	0	ID=cds-CCP46702.1;Parent=gene-Rv3873;Dbxref=EnsemblGenomes-Gn:Rv3873,EnsemblGenomes-Tr:CCP46702,GOA:P9WHW9,InterPro:IPR000030,NCBI_GP:CCP46702.1;Name=CCP46702.1;Note=Rv3873%2C (MTV027.08)%2C len: 368 aa. PPE68%2C Member of the Mycobacterium tuberculosis PPE family%2C highly similar to many e.g. O33085|ML0051|MLCB628.14c from Mycobacterium leprae (302 aa)%2C FASTA scores: opt: 656%2C E(): 2.8e-24%2C(46.2%25 identity in 288 aa overlap)%3B and O53691|Rv0286|MTV035.14 (513 aa)%2C FASTA scores: opt: 566%2CE(): 7.8e-20%2C (35.25%25 identity in 363 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted possible vaccine candidate (See Zvi et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE68;locus_tag=Rv3873;product=PPE family protein PPE68;protein_id=CCP46702.1;transl_table=11
AL123456.3	EMBL	gene	4352274	4352576	.	+	.	ID=gene-Rv3874;Name=esxB;gbkey=Gene;gene=esxB;gene_biotype=protein_coding;gene_synonym=cfp10,lhp;locus_tag=Rv3874
AL123456.3	EMBL	CDS	4352274	4352576	.	+	0	ID=cds-CCP46703.1;Parent=gene-Rv3874;Dbxref=EnsemblGenomes-Gn:Rv3874,EnsemblGenomes-Tr:CCP46703,GOA:P9WNK5,InterPro:IPR010310,PDB:3FAV,NCBI_GP:CCP46703.1;Name=CCP46703.1;Note=Rv3874%2C (MT3988%2C MTV027.09)%2C len: 100 aa. EsxB%2C 10 KDA culture filtrate antigen (see citations below%2Cespecially first)%2C highly similar to O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA culture filtrate antigen CFP10 homolog from Mycobacterium leprae (99 aa)%2C FASTA scores: opt: 237%2C E(): 2.4e-08%2C (39.4%25 identity in 99 aa overlap). Also similar to O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 putative ESAT-6 like protein 13 from Mycobacterium tuberculosis (103 aa) FASTA scores: opt: 126%2C E(): 0.18%2C (23.1%25 identity in 91 aa overlap)%3B and shows some similarity with other proteins from Mycobacterium tuberculosis. Contains probable coiled-coil from aa 49-93. Belongs to the ESAT6 family. Note that previously known as lhp (alternate gene name: cfp10). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxB;locus_tag=Rv3874;product=10 kDa culture filtrate antigen EsxB (LHP) (CFP10);protein_id=CCP46703.1;transl_table=11
AL123456.3	EMBL	gene	4352609	4352896	.	+	.	ID=gene-Rv3875;Name=esxA;gbkey=Gene;gene=esxA;gene_biotype=protein_coding;gene_synonym=esat-6;locus_tag=Rv3875
AL123456.3	EMBL	CDS	4352609	4352896	.	+	0	ID=cds-CCP46704.1;Parent=gene-Rv3875;Dbxref=EnsemblGenomes-Gn:Rv3875,EnsemblGenomes-Tr:CCP46704,GOA:P9WNK7,InterPro:IPR010310,PDB:1WA8,PDB:3FAV,NCBI_GP:CCP46704.1;Name=CCP46704.1;Note=Rv3875%2C (MT3989%2C MTV027.10)%2C len: 95 aa. EsxA%2C early secretory antigenic target (see citations below)%2C identical to Q57165|O84901|ESAT6 early secretory antigenic target from Mycobacterium bovis (94 aa)%2C FASTA scores: opt: 596%2CE(): 4.6e-33%2C (100.0%25 identity in 94 aa overlap). Also similar to Q50206|ESA6_MYCLE|ESAT6|ESX|L45|ML0049|MLCB628.12c 6 KDA early secretory antigenic target homolog (ESAT-6-like protein) (L-ESAT) from Mycobacterium leprae (95 aa)%2C FASTA scores: opt: 236%2C E(): 3.3e-09%2C (36.25%25 identity in 91 aa overlap)%3B and weak similarity with others proteins ESAT-like from Mycobacterium leprae. Also some similarity with O53266|ES69_MYCTU|Rv3019c|MT3104|MTV012.33c putative secreted ESAT-6 like protein 9 from Mycobacterium tuberculosis (96 aa)%2C FASTA scores: opt: 131%2C E(): 0.03%2C(26.15%25 identity in 88 aa overlap)%3B and other ESAT-like protein. Contains probable coiled-coil from 56 to 92 aa. Belongs to the ESAT6 family. Note that previously known as esat-6. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Predicted possible vaccine candidate (See Zvi et al.%2C2008). EspD|Rv3614c expression but not secretion is required for EsxA|Rv3875 secretion (See Chen et al.%2C2012).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=esxA;locus_tag=Rv3875;product=6 kDa early secretory antigenic target EsxA (ESAT-6);protein_id=CCP46704.1;transl_table=11
AL123456.3	EMBL	gene	4353010	4355010	.	+	.	ID=gene-Rv3876;Name=espI;gbkey=Gene;gene=espI;gene_biotype=protein_coding;gene_synonym=snm3;locus_tag=Rv3876
AL123456.3	EMBL	CDS	4353010	4355010	.	+	0	ID=cds-CCP46705.1;Parent=gene-Rv3876;Dbxref=EnsemblGenomes-Gn:Rv3876,EnsemblGenomes-Tr:CCP46705,GOA:P9WJC5,InterPro:IPR025669,InterPro:IPR027417,NCBI_GP:CCP46705.1;Name=CCP46705.1;Note=Rv3876%2C (MTV027.11)%2C len: 666 aa. EspI%2C ESX-1 secretion-associated protein%2C conserved pro-%2C ala-rich protein%2C similar to several proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 hypothetical protein (586 aa)%2CFASTA scores: opt: 1682%2C E(): 2.1e-45%2C (50.75%25 identity in 672 aa overlap)%3B O33082|MLCB628.11c hypothetical 52.0 KDA protein (478 aa)%2C FASTA scores: opt: 1588%2C E(): 1.5e-42%2C(53.5%25 identity in 542 aa overlap) (also has a proline rich N-terminus)%3B etc. Also similar to other proteins from Mycobacterium tuberculosis%2C especially in C-terminus%2C e.g. O06396|Rv0530|MTCY25D10.09 (405 aa)%2C FASTA scores: opt: 670%2C E(): 2.5e-14%2C (34.85%25 identity in 396 aa overlap) (also has Pro-rich N-terminus)%3B etc. Note that N-terminus is repetitive and highly Proline rich.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espI;locus_tag=Rv3876;product=ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein.;protein_id=CCP46705.1;transl_table=11
AL123456.3	EMBL	repeat_region	4353280	4353330	.	+	.	ID=id-Rv3876;Note=51 bp imperfect direct repeat 1%2CGAACCGGCCGCATCTAAACCACCCACACCCCCCATGCCCATCGCCGGACCC;gbkey=repeat_region;gene=espI;locus_tag=Rv3876
AL123456.3	EMBL	repeat_region	4353331	4353381	.	+	.	ID=id-Rv3876-2;Note=51 bp imperfect direct repeat 2%2CGAACCGGCCCCACCCAAACCACCCACACCCCCCATGCCCATCGCCGGACCC;gbkey=repeat_region;gene=espI;locus_tag=Rv3876
AL123456.3	EMBL	repeat_region	4353382	4353432	.	+	.	ID=id-Rv3876-3;Note=51 bp imperfect direct repeat 3%2CGAACCGGCCCCACCCAAACCACCCACACCTCCGATGCCCATCGCCGGACCT;gbkey=repeat_region;gene=espI;locus_tag=Rv3876
AL123456.3	EMBL	gene	4355007	4356542	.	+	.	ID=gene-Rv3877;Name=eccD1;gbkey=Gene;gene=eccD1;gene_biotype=protein_coding;gene_synonym=snm4;locus_tag=Rv3877
AL123456.3	EMBL	CDS	4355007	4356542	.	+	0	ID=cds-CCP46706.1;Parent=gene-Rv3877;Dbxref=EnsemblGenomes-Gn:Rv3877,EnsemblGenomes-Tr:CCP46706,GOA:P9WNQ7,InterPro:IPR006707,InterPro:IPR024962,NCBI_GP:CCP46706.1;Name=CCP46706.1;Note=Rv3877%2C (MTV027.12)%2C len: 511 aa. EccD1%2C esx conserved component%2C ESX-1 type VII secretion system protein%2C probable transmembrane protein%2C equivalent to Q9CDD9|ML0047 putative membrane protein from Mycobacterium leprae (512 aa)%2C FASTA scores: opt: 2496%2C E(): 2.8e-140%2C(74.0%25 identity in 512 aa overlap)%3B and highly similar%2C but longer 32 aa%2C to O33081|MLCB628.10c hypothetical 51.4 KDA protein from Mycobacterium leprae (480 aa)%2C FASTA scores: opt: 2346%2C E(): 2e-131%2C (74.15%25 identity in 480 aa overlap). Shows also similarity with other membrane proteins from Mycobacterium leprae e.g. Q9CBV2|ML1539 probable membrane protein (503 aa)%2C FASTA scores: opt: 318%2CE(): 2e-11%2C (22.7%25 identity in 520 aa overlap). Also similar to various proteins from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 putative membrane protein (503 aa)%2C FASTA scores: opt: 391%2C E(): 9.4e-16%2C (24.45%25 identity in 523 aa overlap)%3B O86362|Rv0290|MTV035.18 hypothetical 47.9 KDA protein (472 aa)%2C FASTA scores: opt: 332%2C E(): 2.8e-12%2C (28.1%25 identity in 509 aa overlap)%3B O05457|Rv3887c|MTCY15F10.25 hypothetical 53.2 KDA protein (509 aa)%2C FASTA scores: opt: 167%2C E(): 0.017%2C (24.0%25 identity in 517 aa overlap)%3B etc. Equivalent to AAK48359 from Mycobacterium tuberculosis strain CDC1551 (479 aa) but longer 32 aa. A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccD1;locus_tag=Rv3877;product=ESX conserved component EccD1. ESX-1 type VII secretion system protein. Probable transmembrane protein.;protein_id=CCP46706.1;transl_table=11
AL123456.3	EMBL	gene	4356693	4357535	.	+	.	ID=gene-Rv3878;Name=espJ;gbkey=Gene;gene=espJ;gene_biotype=protein_coding;gene_synonym=TB27.4;locus_tag=Rv3878
AL123456.3	EMBL	CDS	4356693	4357535	.	+	0	ID=cds-CCP46707.1;Parent=gene-Rv3878;Dbxref=EnsemblGenomes-Gn:Rv3878,EnsemblGenomes-Tr:CCP46707,GOA:P9WJC3,NCBI_GP:CCP46707.1;Name=CCP46707.1;Note=Rv3878%2C (MTV027.13)%2C len: 280 aa. EspJ%2C ESX-1 secretion-associated protein%2C conserved ala-rich protein. Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espJ;locus_tag=Rv3878;product=ESX-1 secretion-associated protein EspJ. Conserved alanine rich protein.;protein_id=CCP46707.1;transl_table=11
AL123456.3	EMBL	gene	4357593	4359782	.	-	.	ID=gene-Rv3879c;Name=espK;gbkey=Gene;gene=espK;gene_biotype=protein_coding;locus_tag=Rv3879c
AL123456.3	EMBL	CDS	4357593	4359782	.	-	0	ID=cds-CCP46708.1;Parent=gene-Rv3879c;Dbxref=EnsemblGenomes-Gn:Rv3879c,EnsemblGenomes-Tr:CCP46708,GOA:P9WJC1,InterPro:IPR010310,NCBI_GP:CCP46708.1;Name=CCP46708.1;Note=Rv3879c%2C (MTV027.14c)%2C len: 729 aa. EspK%2C ESX-1 secretion-associated protein%2C ala- and pro-rich protein (N-terminal end is repetitive and highly Proline-rich). There may be an unknown protein Orf14 encoded in the opposite orientation%2C within rv3879c (See Ahmad et al.%2C1999%3B Daugelat et al.%2C 2003).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espK;locus_tag=Rv3879c;product=ESX-1 secretion-associated protein EspK. Alanine and proline rich protein.;protein_id=CCP46708.1;transl_table=11
AL123456.3	EMBL	gene	4360199	4360546	.	-	.	ID=gene-Rv3880c;Name=espL;gbkey=Gene;gene=espL;gene_biotype=protein_coding;locus_tag=Rv3880c
AL123456.3	EMBL	CDS	4360199	4360546	.	-	0	ID=cds-CCP46709.1;Parent=gene-Rv3880c;Dbxref=EnsemblGenomes-Gn:Rv3880c,EnsemblGenomes-Tr:CCP46709,GOA:P9WJB9,InterPro:IPR004401,NCBI_GP:CCP46709.1;Name=CCP46709.1;Note=Rv3880c%2C (MTV027.15c)%2C len: 115 aa. EspL%2C ESX-1 secretion-associated protein%2C equivalent to O33080|ML0044|MLCB628.09 hypothetical 12.2 KDA protein from Mycobacterium leprae (113 aa)%2C FASTA scores: opt: 397%2C E(): 2e-19%2C (56.35%25 identity in 110 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espL;locus_tag=Rv3880c;product=ESX-1 secretion-associated protein EspL;protein_id=CCP46709.1;transl_table=11
AL123456.3	EMBL	gene	4360543	4361925	.	-	.	ID=gene-Rv3881c;Name=espB;gbkey=Gene;gene=espB;gene_biotype=protein_coding;locus_tag=Rv3881c
AL123456.3	EMBL	CDS	4360543	4361925	.	-	0	ID=cds-CCP46710.1;Parent=gene-Rv3881c;Dbxref=EnsemblGenomes-Gn:Rv3881c,EnsemblGenomes-Tr:CCP46710,GOA:P9WJD9,NCBI_GP:CCP46710.1;Name=CCP46710.1;Note=Rv3881c%2C (MTV027.16c)%2C len: 460 aa. EspB%2C ESX-1 substrate protein B (See McLaughlin et al.%2C 2007). Conserved ala-%2C gly-rich protein. C-terminal end highly similar to O06126 hypothetical 9.5 KDA protein (fragment) from Mycobacterium tuberculosis strain NTI 64719 (90 aa) FASTA scores: opt: 333%2C E(): 6.3e-07%2C (69.75%25 identity in 86 aa overlap) but sequence difference causes frameshift in NTI 64719. Also similar to part of small Mycobacterium leprae ORF O33078|MLCB628.06 (EMBL:Y14967) (101 aa)%2C FASTA scores: opt: 194%2C E(): 0.04%2C (59.3%25 identity in 54 aa overlap)%2C suggesting this is represented by a pseudogene in Mycobacterium leprae.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=espB;locus_tag=Rv3881c;product=Secreted ESX-1 substrate protein B%2C EspB. Conserved alanine and glycine rich protein;protein_id=CCP46710.1;transl_table=11
AL123456.3	EMBL	gene	4362032	4363420	.	-	.	ID=gene-Rv3882c;Name=eccE1;gbkey=Gene;gene=eccE1;gene_biotype=protein_coding;gene_synonym=snm7;locus_tag=Rv3882c
AL123456.3	EMBL	CDS	4362032	4363420	.	-	0	ID=cds-CCP46711.1;Parent=gene-Rv3882c;Dbxref=EnsemblGenomes-Gn:Rv3882c,EnsemblGenomes-Tr:CCP46711,GOA:P9WJE9,InterPro:IPR021368,NCBI_GP:CCP46711.1;Name=CCP46711.1;Note=Rv3882c%2C (MTV027.17c%2C MTCY15F10.30)%2C len: 462 aa. eccE1%2C esx conserved component%2C ESX-1 type VII secretion system protein%2C possible membrane protein%2C equivalent to O33077|ML0042|MLCB628.05 putative membrane protein from Mycobacterium leprae (467 aa)%2C FASTA scores: opt: 2346%2CE(): 1.1e-140%2C (72.1%25 identity in 462 aa overlap). Also similar to O05459|Rv3885c|MTCY15F10.27 possible membrane protein from Mycobacterium tuberculosis (537 aa) FASTA scores: opt: 283%2C E(): 2.5e-10%2C (26.8%25 identity in 414 aa overlap)%3B and C-terminal end shows similarity with AAK48368|MT4000 hypothetical 45.6 KDA protein from Mycobacterium tuberculosis strain CDC1551 (422 aa) FASTA scores: opt: 215%2C E(): 4.1e-06%2C (26.85%25 identity in 320 aa overlap). A core mycobacterial gene%3B conserved in mycobacterial strains (See Marmiesse et al.%2C 2004). Rv3614c and Rv3882c interact%2C by yeast two-hybrid analysis (See MacGurn et al.%2C 2005).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccE1;locus_tag=Rv3882c;product=ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein.;protein_id=CCP46711.1;transl_table=11
AL123456.3	EMBL	gene	4363417	4364757	.	-	.	ID=gene-Rv3883c;Name=mycP1;gbkey=Gene;gene=mycP1;gene_biotype=protein_coding;gene_synonym=snm8;locus_tag=Rv3883c
AL123456.3	EMBL	CDS	4363417	4364757	.	-	0	ID=cds-CCP46712.1;Parent=gene-Rv3883c;Dbxref=EnsemblGenomes-Gn:Rv3883c,EnsemblGenomes-Tr:CCP46712,GOA:O05461,InterPro:IPR000209,InterPro:IPR015500,InterPro:IPR023834,UniProtKB/TrEMBL:O05461,NCBI_GP:CCP46712.1;Name=CCP46712.1;Note=Rv3883c%2C (MTCY15F10.29)%2C len: 446 aa. MycP1%2Cmembrane-anchored serine protease (mycosin) (see citations below)%2C equivalent to O33076|ML0041|MLCB628.04 probable secreted protease from Mycobacterium leprae (446 aa)%2C FASTA scores: opt: 2448%2C E(): 1.5e-124%2C (79.15%25 identity in 446 aa overlap)%3B and highly similar%2C but in part%2C to several putative proteases from Mycobacterium leprae%3B Q9CBV3|ML1538 (567 aa) FASTA scores: opt: 902%2C E(): 3e-41%2C (37.25%25 identity in 556 aa overlap)%3B and Q9CD36|ML2528 (475 aa)%2CFASTA scores: opt: 873%2C E(): 9.4e-40%2C (42.7%25 identity in 459 aa overlap). Shows also similarity with several proteases from other organisms e.g. Q9PCD0|XF1851 serine protease from Xylella fastidiosa (1000 aa)%2C FASTA scores: opt: 281%2C E(): 1.3e-07%2C (27.95%25 identity in 422 aa overlap)%3B P42780|BPRX_BACNO extracellular subtilisin-like protease precursor from Bacteroides nodosus (Dichelobacter nodosus) (595 aa)%2C FASTA scores: opt: 270%2C E(): 3.2e-07%2C(28.9%25 identity in 384 aa overlap)%3B Q46541|APRV5 acidic protease V5 from Bacteroides nodosus (Dichelobacter nodosus) (595 aa)%2C FASTA scores: opt: 264%2C E(): 6.8e-07%2C(28.65%25 identity in 384 aa overlap)%3B etc. Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53695|Rv0291|MTV035.19 probable membrane-anchored mycosin MYCP3 (461 aa)%2C FASTA scores: opt: 1168%2C E(): 1.2e-55%2C (44.6%25 identity in 453 aa overlap)%3B O53945|Rv1796|MTV049.18 probable membrane-anchored mycosin MYCP5 (585 aa)%2C FASTA scores: opt: 928%2C E(): 1.2e-42%2C(37.85%25 identity in 555 aa overlap) (note gap from aa 155-264)%3B and downstream ORF O05458|Rv3886c|MTCY15F10.26 probable membrane-anchored mycosin MYCP2 (550 aa)%2C FASTA scores: opt: 910%2C E(): 1.1e-41%2C (40.15%25 identity in 533 aa overlap) (note partial gap from aa 146-234)%3B etc. Equivalent to AAK48366 from Mycobacterium tuberculosis strain CDC1551 (411 aa) but longer 35 aa. Has signal sequence with possible signal peptidase I cleavage site in residues 19-21 (ASA) and hydrophobic stretch at C-terminus%2Cfollowed by short positively charged segment%2C that seems to act as a membrane anchor. Activated by Ca2+ (see Dave et al.%2C 2002). Contains three serine protease%2C subtilase family active site motifs: a aspartic acid active site motif (PS00136)%3B a histidine active site motif (PS00137)%3B and a serine active site motif (PS00138). Belongs to peptidase family S8 (also known as the subtilase family)%2Cpyrolysin subfamily. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mycP1;locus_tag=Rv3883c;product=Membrane-anchored mycosin MycP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1);protein_id=CCP46712.1;transl_table=11
AL123456.3	EMBL	gene	4364979	4366838	.	-	.	ID=gene-Rv3884c;Name=eccA2;gbkey=Gene;gene=eccA2;gene_biotype=protein_coding;locus_tag=Rv3884c
AL123456.3	EMBL	CDS	4364979	4366838	.	-	0	ID=cds-CCP46713.1;Parent=gene-Rv3884c;Dbxref=EnsemblGenomes-Gn:Rv3884c,EnsemblGenomes-Tr:CCP46713,GOA:P9WPH7,InterPro:IPR000641,InterPro:IPR003593,InterPro:IPR003959,InterPro:IPR023835,InterPro:IPR027417,NCBI_GP:CCP46713.1;Name=CCP46713.1;Note=Rv3884c%2C (MTCY15F10.28)%2C len: 619 aa. eccA2%2C esx conserved component%2C ESX-2 type VII secretion system protein. Probable CbxX/CfqX protein family%2C similar to hypothetical proteins from Mycobacterium leprae e.g. Q9CD28|Y282_MYCLE|ML2537 (640 aa)%2C FASTA scores: opt: 725%2CE(): 2.9e-34%2C (28.95%25 identity in 587 aa overlap)%3B O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (belongs to the CbxX/CfqX family) (573 aa)%3B Q9CBV5|ML1536 (610 aa) FASTA scores: opt: 648%2C E(): 7.4e-30%2C (31.5%25 identity in 549 aa overlap). Also similar to proteins belonging to the CbxX/CfqX family e.g. Q9RKZ2|SC6D7.05c putative CbxX/CfqX family protein from Streptomyces coelicolor (618 aa) FASTA scores: opt: 557%2C E(): 1.3e-24%2C (28.6%25 identity in 601 aa overlap)%3B P27643|SP5K_BACSU|SPOVK|SPOVJ stage V sporulation protein K from Bacillus subtilis (322 aa) FASTA scores: opt: 485%2C E(): 1.1e-20%2C (35.0%25 identity in 280 aa overlap) (similarity only at C-terminus)%3B Q9KAC6|BH2363 stage V sporulation protein K from Bacillus halodurans (315 aa)%2CFASTA scores: opt: 462%2C E(): 2.2e-19%2C (36.05%25 identity in 244 aa overlap) (similarity only at C-terminus)%3B etc. And similar to hypothetical proteins from Mycobacterium tuberculosis belonging to the CbxX/CfqX family e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10 hypothetical 68.1 KDA protein (631 aa)%2C FASTA scores: opt: 743%2C E(): 2.6e-35%2C(29.9%25 identity in 612 aa overlap)%3B O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 hypothetical 62.4 KDA protein (573 aa)%2C FASTA scores: opt: 678%2C E(): 1.3e-31%2C(31.25%25 identity in 589 aa overlap)%3B O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA scores: opt: 669%2C E(): 4.6e-31%2C (30.95%25 identity in 549 aa overlap)%3B etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Seems to belong to the CbxX/CfqX family.;gbkey=CDS;gene=eccA2;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3884c;product=ESX conserved component EccA2. ESX-2 type VII secretion system protein. Probable CbxX/CfqX family protein.;protein_id=CCP46713.1;transl_table=11
AL123456.3	EMBL	gene	4366908	4368521	.	-	.	ID=gene-Rv3885c;Name=eccE2;gbkey=Gene;gene=eccE2;gene_biotype=protein_coding;locus_tag=Rv3885c
AL123456.3	EMBL	CDS	4366908	4368521	.	-	0	ID=cds-CCP46714.1;Parent=gene-Rv3885c;Dbxref=EnsemblGenomes-Gn:Rv3885c,EnsemblGenomes-Tr:CCP46714,GOA:P9WJE7,InterPro:IPR021368,NCBI_GP:CCP46714.1;Name=CCP46714.1;Note=Rv3885c%2C (MTCY15F10.27)%2C len: 537 aa. eccE2%2C esx conserved component%2C ESX-2 type VII secretion system protein. possible membrane protein (has hydrophobic stretch near N-terminus)%2C showing some similarity with O05462|Rv3882c|MTV027.17c|MTCY15F10.30 possible membrane protein from Mycobacterium tuberculosis (462 aa) FASTA scores: opt: 283%2C E(): 8.3e-10%2C (26.55%25 identity in 414 aa overlap)%3B and O33077|ML0042|MLCB628.05 putative membrane protein from Mycobacterium leprae (467 aa)%2C FASTA scores: opt: 260%2C E(): 2.1e-08%2C (28.0%25 identity in 382 aa overlap). Equivalent to AAK48368 from Mycobacterium tuberculosis strain CDC1551 (422 aa) but longer 115 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccE2;locus_tag=Rv3885c;product=ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein.;protein_id=CCP46714.1;transl_table=11
AL123456.3	EMBL	gene	4368518	4370170	.	-	.	ID=gene-Rv3886c;Name=mycP2;gbkey=Gene;gene=mycP2;gene_biotype=protein_coding;locus_tag=Rv3886c
AL123456.3	EMBL	CDS	4368518	4370170	.	-	0	ID=cds-CCP46715.1;Parent=gene-Rv3886c;Dbxref=EnsemblGenomes-Gn:Rv3886c,EnsemblGenomes-Tr:CCP46715,GOA:O05458,InterPro:IPR000209,InterPro:IPR015500,InterPro:IPR023827,InterPro:IPR023834,UniProtKB/TrEMBL:O05458,NCBI_GP:CCP46715.1;Name=CCP46715.1;Note=Rv3886c%2C (MTCY15F10.26)%2C len: 550 aa. Probable mycP2%2C ala-%2C pro-rich membrane-anchored serine protease (mycosin) (see citation below)%2C highly similar to Q9CBV3|ML1538 possible protease from Mycobacterium leprae (567 aa)%2C FASTA scores: opt: 1034%2C E(): 3.9e-32%2C (43.5%25 identity in 575 aa overlap)%3B and highly similar%2C but with gaps%2C to several putative proteases from Mycobacterium leprae%3B O33076|ML0041|MLCB628.04 (446 aa)%2C FASTA scores: opt: 860%2C E(): 1.1e-25%2C (38.65%25 identity in 538 aa overlap)%3B Q9CD36|ML2528 (475 aa) (475 aa)%2C FASTA scores: opt: 413%2C E(): 7.1e-09%2C (37.7%25 identity in 562 aa overlap). Also similarity with Q99405|PRTM_BACSP M-protease from Bacillus sp. strain KSM-K16 (269 aa)%2C FASTA scores: E(): 7.6e-06%2C (27.1%25 identity in 277 aa overlap). And highly similar%2C but also with gaps%2C to other mycosins from Mycobacterium tuberculosis e.g. O53945|Rv1796|MTV049.18 (585 aa)%2C FASTA scores: opt: 1173%2C E(): 2.4e-37%2C (47.9%25 identity in 578 aa overlap)%3B the upstream ORF O05461|Rv3883c|MTCY15F10.29 (446 aa) FASTA scores: opt: 910%2C E(): 1.5e-27%2C (40.15%25 identity in 533 aa overlap)%3B O06316|Rv3449|MTCY13E12.02 (455 aa) FASTA scores: opt: 477%2CE(): 2.7e-11%2C (38.75%25 identity in 550 aa overlap)%3B etc. Contains Pro rich protein with two serine protease%2Csubtilase family active site motifs: aspartic acid active site motif (PS00136)%3B and histidine active site motif (PS00137). Belongs to peptidase family S8 (also known as the subtilase family)%2C pyrolysin subfamily. Thought to be cleaved into smaller molecular weight proteins%2C 36 and 29 KDA (see citation below).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mycP2;inference=protein motif:PROSITE:PS00137;locus_tag=Rv3886c;product=Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2);protein_id=CCP46715.1;transl_table=11
AL123456.3	EMBL	gene	4370155	4371684	.	-	.	ID=gene-Rv3887c;Name=eccD2;gbkey=Gene;gene=eccD2;gene_biotype=protein_coding;locus_tag=Rv3887c
AL123456.3	EMBL	CDS	4370155	4371684	.	-	0	ID=cds-CCP46716.1;Parent=gene-Rv3887c;Dbxref=EnsemblGenomes-Gn:Rv3887c,EnsemblGenomes-Tr:CCP46716,GOA:P9WNQ5,InterPro:IPR006707,InterPro:IPR024962,NCBI_GP:CCP46716.1;Name=CCP46716.1;Note=Rv3887c%2C (MTCY15F10.25)%2C len: 509 aa. eccD2%2C esx conserved component%2C ESX-2 type VII secretion system protein%2C probable transmembrane protein (has hydrophilic stretch from ~~1-130 then very hydrophobic domain)%2C similar to other membrane proteins and with weak similarity to known transporters%2C e.g. Q9CBV2|ML1539 probable membrane protein from Mycobacterium leprae (503 aa)%2C FASTA scores: opt: 395%2C E(): 2.3e-16%2C (28.0%25 identity in 496 aa overlap)%3B Q9CD35|ML2529 conserved membrane protein from Mycobacterium leprae (485 aa)%2C FASTA scores: opt: 221%2C E(): 6.6e-06%2C(24.6%25 identity in 423 aa overlap)%3B Q9ADP8|2SC10A7.11 putative integral membrane protein from Streptomyces coelicolor (430 aa)%2C FASTA scores: opt: 171%2C E(): 0.0062%2C(26.55%25 identity in 358 aa overlap)%3B CAC44275|SCBAC17F8.03 putative drug efflux protein from Streptomyces coelicolor (416 aa)%2C FASTA scores: opt: 160%2C E(): 0.028%2C (27.85%25 identity in 323 aa overlap)%3B etc. Also similar to others from Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17 putative membrane protein (503 aa)%2CFASTA scores: opt: 360%2C E(): 2.9e-14%2C (26.65%25 identity in 514 aa overlap)%3B etc. Equivalent to AAK48369 from Mycobacterium tuberculosis strain CDC1551 (469 aa) but longer 40 aa.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccD2;locus_tag=Rv3887c;product=ESX conserved component EccD2. ESX-2 type VII secretion system protein. Probable transmembrane protein.;protein_id=CCP46716.1;transl_table=11
AL123456.3	EMBL	gene	4371681	4372706	.	-	.	ID=gene-Rv3888c;Name=Rv3888c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3888c
AL123456.3	EMBL	CDS	4371681	4372706	.	-	0	ID=cds-CCP46717.1;Parent=gene-Rv3888c;Dbxref=EnsemblGenomes-Gn:Rv3888c,EnsemblGenomes-Tr:CCP46717,GOA:O05456,InterPro:IPR025669,InterPro:IPR027417,UniProtKB/TrEMBL:O05456,NCBI_GP:CCP46717.1;Name=CCP46717.1;Note=Rv3888c%2C (MTCY15F10.24)%2C len: 341 aa. Probable conserved membrane protein%2C showing similarity with hypothetical proteins from Mycobacterium leprae: O33082|MLCB628.11c (478 aa)%2C FASTA scores: opt: 530%2C E(): 7.7e-26%2C (32.45%25 identity in 336 aa overlap)%3B Q9CDD8|ML0048 (586 aa)%2C FASTA scores: opt: 530%2C E(): 9.1e-26%2C (32.45%25 identity in 336 aa overlap)%3B Q9CCI1|ML0798 (592 aa)%2C FASTA scores: opt: 426%2C E(): 3e-19%2C (27.5%25 identity in 342 aa overlap) (similarity only at C-terminus). Also similar to proteins from Mycobacterium tuberculosis e.g. P96217|Rv3860|MTCY01A6.08c (390 aa)%2C FASTA scores: opt: 603%2C E(): 1.7e-30%2C (35.2%25 identity in 284 aa overlap)%3B O06396|Rv0530|MTCY25D10.09 (405 aa)%2C FASTA scores: opt: 573%2C E(): 1.3e-28%2C (32.0%25 identity in 328 aa overlap)%3B C-terminus of O69740|Rv3876|MTV027.1 (666 aa)%2C FASTA scores: opt: 509%2C E(): 2.1e-24%2C (31.0%25 identity in 303 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3888c;product=Probable conserved membrane protein;protein_id=CCP46717.1;transl_table=11
AL123456.3	EMBL	gene	4372800	4373630	.	-	.	ID=gene-Rv3889c;Name=espG2;gbkey=Gene;gene=espG2;gene_biotype=protein_coding;locus_tag=Rv3889c
AL123456.3	EMBL	CDS	4372800	4373630	.	-	0	ID=cds-CCP46718.1;Parent=gene-Rv3889c;Dbxref=EnsemblGenomes-Gn:Rv3889c,EnsemblGenomes-Tr:CCP46718,InterPro:IPR025734,NCBI_GP:CCP46718.1;Name=CCP46718.1;Note=Rv3889c%2C (MTCY15F10.23)%2C len: 276 aa. EspG2%2C ESX-2 secretion-associated protein.;gbkey=CDS;gene=espG2;locus_tag=Rv3889c;product=ESX-2 secretion-associated protein EspG2;protein_id=CCP46718.1;transl_table=11
AL123456.3	EMBL	gene	4373726	4374013	.	-	.	ID=gene-Rv3890c;Name=esxC;gbkey=Gene;gene=esxC;gene_biotype=protein_coding;gene_synonym=ES6_11;locus_tag=Rv3890c
AL123456.3	EMBL	CDS	4373726	4374013	.	-	0	ID=cds-CCP46719.1;Parent=gene-Rv3890c;Dbxref=EnsemblGenomes-Gn:Rv3890c,EnsemblGenomes-Tr:CCP46719,InterPro:IPR010310,InterPro:IPR020167,NCBI_GP:CCP46719.1;Name=CCP46719.1;Note=Rv3890c%2C (MT4005%2C MTCY15F10.22)%2C len: 95 aa. EsxC%2CESAT-6 like protein (see Gey Van Pittius et al.%2C 2001)%2Cequivalent to Q9K548|ES6B_MYCPA putative ESAT-6 like protein 11 (ORF3890C) from Mycobacterium paratuberculosis (95 aa)%2C FASTA scores: opt: 490%2C E(): 3.3e-26%2C (76.85%25 identity in 95 aa overlap). Belongs to the ESAT6 family.;gbkey=CDS;gene=esxC;locus_tag=Rv3890c;product=ESAT-6 like protein EsxC (ESAT-6 like protein 11);protein_id=CCP46719.1;transl_table=11
AL123456.3	EMBL	gene	4374049	4374372	.	-	.	ID=gene-Rv3891c;Name=esxD;gbkey=Gene;gene=esxD;gene_biotype=protein_coding;locus_tag=Rv3891c
AL123456.3	EMBL	CDS	4374049	4374372	.	-	0	ID=cds-CCP46720.1;Parent=gene-Rv3891c;Dbxref=EnsemblGenomes-Gn:Rv3891c,EnsemblGenomes-Tr:CCP46720,InterPro:IPR010310,UniProtKB/TrEMBL:O05453,NCBI_GP:CCP46720.1;Name=CCP46720.1;Note=Rv3891c%2C (MTCY15F10.21)%2C len: 107 aa (first GTG taken). EsxD%2C ESAT-6 like protein%2C equivalent to Q9K547 hypothetical 10.3 KDA protein (fragment) from Mycobacterium paratuberculosis (100 aa)%2C FASTA scores: opt: 498%2C E(): 1.7e-26%2C (77.25%25 identity in 101 aa overlap). Seems to belong to the ESAT6 family (see Gey Van Pittius et al.%2C2001).;gbkey=CDS;gene=esxD;locus_tag=Rv3891c;product=Possible ESAT-6 like protein EsxD;protein_id=CCP46720.1;transl_table=11
AL123456.3	EMBL	gene	4374484	4375683	.	-	.	ID=gene-Rv3892c;Name=PPE69;gbkey=Gene;gene=PPE69;gene_biotype=protein_coding;locus_tag=Rv3892c
AL123456.3	EMBL	CDS	4374484	4375683	.	-	0	ID=cds-CCP46721.1;Parent=gene-Rv3892c;Dbxref=EnsemblGenomes-Gn:Rv3892c,EnsemblGenomes-Tr:CCP46721,InterPro:IPR000030,NCBI_GP:CCP46721.1;Name=CCP46721.1;Note=Rv3892c%2C (MTCY15F10.20)%2C len: 399 aa. PPE69%2C Member of the Mycobacterium tuberculosis PPE family of conserved proteins%2C similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (391 aa)%2C FASTA scores: opt: 348%2CE(): 2.2e-08%2C (26.6%25 identity in 380 aa overlap).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=PPE69;locus_tag=Rv3892c;product=PPE family protein PPE69;protein_id=CCP46721.1;transl_table=11
AL123456.3	EMBL	gene	4375762	4375995	.	-	.	ID=gene-Rv3893c;Name=PE36;gbkey=Gene;gene=PE36;gene_biotype=protein_coding;locus_tag=Rv3893c
AL123456.3	EMBL	CDS	4375762	4375995	.	-	0	ID=cds-CCP46722.1;Parent=gene-Rv3893c;Dbxref=EnsemblGenomes-Gn:Rv3893c,EnsemblGenomes-Tr:CCP46722,InterPro:IPR000084,UniProtKB/TrEMBL:L7N660,NCBI_GP:CCP46722.1;Name=CCP46722.1;Note=Rv3893c%2C (MTCY15F10.19)%2C len: 77 aa. PE36%2C Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below)%2C similar to others e.g. O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis (102 aa)%2C FASTA scores: opt: 136%2C E(): 0.042%2C (35.6%25 identity in 73 aa overlap).;gbkey=CDS;gene=PE36;locus_tag=Rv3893c;product=PE family protein PE36;protein_id=CCP46722.1;transl_table=11
AL123456.3	EMBL	gene	4376262	4380452	.	-	.	ID=gene-Rv3894c;Name=eccC2;gbkey=Gene;gene=eccC2;gene_biotype=protein_coding;locus_tag=Rv3894c
AL123456.3	EMBL	CDS	4376262	4380452	.	-	0	ID=cds-CCP46723.1;Parent=gene-Rv3894c;Dbxref=EnsemblGenomes-Gn:Rv3894c,EnsemblGenomes-Tr:CCP46723,GOA:O05450,InterPro:IPR002543,InterPro:IPR023836,InterPro:IPR023837,InterPro:IPR027417,UniProtKB/TrEMBL:O05450,NCBI_GP:CCP46723.1;Name=CCP46723.1;Note=Rv3894c%2C (MTCY15F10.18)%2C len: 1396 aa. EccC2%2C esx conserved component%2C ESX-2 type VII secretion system protein%2C possible membrane protein (possible transmembrane segments from aa ~~37-85)%2C similar to Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa)%2CFASTA scores: opt: 652%2C E(): 2.2e-30%2C (27.85%25 identity in 1425 aa overlap)%3B Q9CDD7|ML0052 hypothetical protein from Mycobacterium leprae (597 aa)%2C FASTA scores: opt: 537%2C E(): 6.6e-24%2C (27.5%25 identity in 585 aa overlap) (similarity only with C-terminal end)%3B Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane protein from Mycobacterium leprae (1345 aa)%2C FASTA scores: opt: 523%2C E(): 8.6e-23%2C(31.65%25 identity in 1412 aa overlap). Also similar to various proteins e.g. O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa)%2C FASTA scores: opt: 973%2C E(): 2.8e-49%2C (28.1%25 identity in 1409 aa)%3B Q9L0T6|SCD35.15c putative cell division-related protein from Streptomyces coelicolor(1525 aa)%2C FASTA scores: opt: 524%2C E(): 8.3e-23%2C (24.95%25 identity in 1450 aa overlap)%3B Q9KE81|BH0975 hypothetical protein from Bacillus halodurans (1489 aa)%2C FASTA scores: opt: 444%2C E(): 4.1e-18%2C(22.5%25 identity in 1346 aa overlap)%3B etc. Also similar to AAK46103|MT1833 FTSK/SPOIIIE family protein from Mycobacterium tuberculosis strain CDC1551 (1391 aa)%2C FASTA scores: opt: 769%2C E(): 2.9e-37%2C (30.6%25 identity in 1434 aa overlap)%3B and other hypothetical proteins from Mycobacterium tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa)%2C FASTA scores: opt: 634%2C E(): 2.5e-29%2C (28.2%25 identity in 1443 aa overlap)%3B O06264|Rv3447c|MTCY77.19c (1236 aa)%2C FASTA scores: opt: 632%2C E(): 3.1e-29%2C (28.75%25 identity in 1391 aa overlap)%3B O69736|R3871|MTV027.06 (591 aa)%2C FASTA scores: opt: 588%2C E(): 6.6e-27%2C (27.75%25 identity in 605 aa overlap) (similarity only with C-terminal end)%3B etc. Contains two possible (PS00017) ATP/GTP-binding sites (P-loop) in central portion.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccC2;inference=protein motif:PROSITE:PS00017;locus_tag=Rv3894c;product=ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein.;protein_id=CCP46723.1;transl_table=11
AL123456.3	EMBL	gene	4380453	4381940	.	-	.	ID=gene-Rv3895c;Name=eccB2;gbkey=Gene;gene=eccB2;gene_biotype=protein_coding;locus_tag=Rv3895c
AL123456.3	EMBL	CDS	4380453	4381940	.	-	0	ID=cds-CCP46724.1;Parent=gene-Rv3895c;Dbxref=EnsemblGenomes-Gn:Rv3895c,EnsemblGenomes-Tr:CCP46724,GOA:P9WNR5,InterPro:IPR007795,NCBI_GP:CCP46724.1;Name=CCP46724.1;Note=Rv3895c%2C (MTCY15F10.17)%2C len: 495 aa. EccB2%2C esx conserved component%2C ESX-2 type VII secretion system protein%2C probable membrane protein%2C highly similar to two conserved membrane protein from Mycobacterium leprae: Q9Z5I3|ML1544|MLCB596.27 (506 aa)%2C FASTA scores: opt: 1070%2CE(): 1.4e-53%2C (39.8%25 identity in 485 aa overlap)%3B and Q9CD29|ML2536 (552 aa)%2C FASTA scores: opt: 483%2C E(): 4e-20%2C(36.85%25 identity in 499 aa overlap). Also highly similar to various proteins from Mycobacterium tuberculosis e.g. O53933|Rv1782|MTV049.04 hypothetical protein (506 aa)%2CFASTA scores: opt: 1106%2C E(): 1.2e-55%2C (41.25%25 identity in 485 aa overlap)%3B O69734|Rv3869|MTV027.04 hypothetical protein (480 aa)%2C FASTA scores: opt: 795%2C E(): 6.1e-38%2C(36.0%25 identity in 486 aa overlap)%3B O33088|ML0054|MLCB628.17c putative membrane protein (481 aa)%2C FASTA scores: opt: 740%2C E(): 8.3e-35%2C (35.65%25 identity in 485 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=eccB2;locus_tag=Rv3895c;product=ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein.;protein_id=CCP46724.1;transl_table=11
AL123456.3	EMBL	gene	4381943	4382851	.	-	.	ID=gene-Rv3896c;Name=Rv3896c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3896c
AL123456.3	EMBL	CDS	4381943	4382851	.	-	0	ID=cds-CCP46725.1;Parent=gene-Rv3896c;Dbxref=EnsemblGenomes-Gn:Rv3896c,EnsemblGenomes-Tr:CCP46725,InterPro:IPR008258,InterPro:IPR023346,UniProtKB/TrEMBL:O05448,NCBI_GP:CCP46725.1;Name=CCP46725.1;Note=Rv3896c%2C (MTCY15F10.16)%2C len: 302 aa (first GTG taken%2C although TBParse suggests TTG at 16079). Putative conserved ala-rich protein. C-terminus highly similar to C-terminal end of other proteins e.g. Q9XAS4|SC10A7.01 hypothetical 17.2 KDA protein from Streptomyces coelicolor (244 aa)%2C FASTA scores: opt: 255%2C E(): 1.4e-08%2C (32.0%25 identity in 222 aa overlap)%3B CAC44611|STBAC16H6.32 putative secreted protein from Streptomyces coelicolor (172 aa)%2CFASTA scores: opt: 214%2C E(): 3.4e-06%2C (42.55%25 identity in 94 aa overlap)%3B Q38352|ORF360 from Lactococcus delbrueckii bacteriophage ll-H (360 aa)%2C FASTA scores: opt: 211%2C E(): 9.5e-06%2C (40.0%25 identity in 115 aa overlap)%3B P54334|XKDO_BACSU|XKDO phage-like element PBSX protein from Bacillus subtilis (1332 aa)%2C FASTA scores: opt: 209%2C E(): 3.6e-05%2C (38.35%25 identity in 86 aa overlap)%3B etc. Also similar to P71594|P71594|Rv0024|MTCY10H4.24 hypothetical 30.3 KDA protein from Mycobacterium tuberculosis (281 aa)%2CFASTA scores: opt: 265%2C E(): 3.9e-09%2C (29.25%25 identity in 287 aa overlap).;gbkey=CDS;locus_tag=Rv3896c;product=Conserved hypothetical protein;protein_id=CCP46725.1;transl_table=11
AL123456.3	EMBL	gene	4383008	4383640	.	-	.	ID=gene-Rv3897c;Name=Rv3897c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3897c
AL123456.3	EMBL	CDS	4383008	4383640	.	-	0	ID=cds-CCP46726.1;Parent=gene-Rv3897c;Dbxref=EnsemblGenomes-Gn:Rv3897c,EnsemblGenomes-Tr:CCP46726,UniProtKB/TrEMBL:O07036,NCBI_GP:CCP46726.1;Name=CCP46726.1;Note=Rv3897c%2C (MTCY15F10.15)%2C len: 210 aa. Conserved hypothetical protein%2C highly similar in part to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 hypothetical 30.8 KDA protein from Mycobacterium tuberculosis (314 aa) FASTA scores: opt: 815%2C E(): 4.7e-26%2C (73.05%25 identity in 167 aa overlap). Similarity to MTCY49.22 suggests that this is a continuation of MTCY15F10.14. There is a frameshift mutation near 3'-end with respect to this sequence as well%2Csimilarity to MTCY49.22 continues in an overlapping ORF. Sequence appears to be correct.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3897c;product=Conserved hypothetical protein;protein_id=CCP46726.1;transl_table=11
AL123456.3	EMBL	gene	4383653	4383985	.	-	.	ID=gene-Rv3898c;Name=Rv3898c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3898c
AL123456.3	EMBL	CDS	4383653	4383985	.	-	0	ID=cds-CCP46727.1;Parent=gene-Rv3898c;Dbxref=EnsemblGenomes-Gn:Rv3898c,EnsemblGenomes-Tr:CCP46727,UniProtKB/TrEMBL:O05447,NCBI_GP:CCP46727.1;Name=CCP46727.1;Note=Rv3898c%2C (MTCY15F10.14)%2C len: 110 aa. Conserved hypothetical protein. Highly similar%2C but in part%2C to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 hypothetical 30.8 KDA protein from Mycobacterium tuberculosis (314 aa) FASTA scores: opt: 204%2C E(): 0.00042%2C (50.6%25 identity in 81 aa overlap). Similarity suggests it should be in frame with next ORF and that the stop codon could be read through%2C the sequence appears to be correct. Homology lost upstream at 15138 gatc sequence may suggest discontinuity due to chimerism in cY15F10 or cY49.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3898c;product=Conserved hypothetical protein;protein_id=CCP46727.1;transl_table=11
AL123456.3	EMBL	gene	4384147	4385379	.	-	.	ID=gene-Rv3899c;Name=Rv3899c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3899c
AL123456.3	EMBL	CDS	4384147	4385379	.	-	0	ID=cds-CCP46728.1;Parent=gene-Rv3899c;Dbxref=EnsemblGenomes-Gn:Rv3899c,EnsemblGenomes-Tr:CCP46728,GOA:O05446,UniProtKB/TrEMBL:O05446,NCBI_GP:CCP46728.1;Name=CCP46728.1;Note=Rv3899c%2C (MTCY15F10.13)%2C len: 410 aa. Conserved hypothetical protein%2C similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 hypothetical 15.1 KDA protein (fragment) (143 aa) FASTA scores: opt: 562%2C E(): 4e-16%2C (69.0%25 identity in 142 aa overlap)%3B and the N-terminal end is highly similar%2C but longer 65 aa%2C to O07266 hypothetical 13.7 KDA protein (fragment) (143 aa)%2C FASTA scores: opt: 562%2C E(): 4e-16%2C(69.0%25 identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 hypothetical 73.6 KDA protein (721 aa)%2C FASTA scores: opt: 1388%2C E(): 1.5e-48%2C (55.25%25 identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 hypothetical 39.6 KDA protein (365 aa)%2C FASTA scores: opt: 403%2C E(): 1.7e-09%2C(33.75%25 identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3899c;product=Conserved hypothetical protein;protein_id=CCP46728.1;transl_table=11
AL123456.3	EMBL	gene	4385373	4386308	.	-	.	ID=gene-Rv3900c;Name=Rv3900c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3900c
AL123456.3	EMBL	CDS	4385373	4386308	.	-	0	ID=cds-CCP46729.1;Parent=gene-Rv3900c;Dbxref=EnsemblGenomes-Gn:Rv3900c,EnsemblGenomes-Tr:CCP46729,GOA:O05445,UniProtKB/TrEMBL:O05445,NCBI_GP:CCP46729.1;Name=CCP46729.1;Note=Rv3900c%2C (MTCY15F10.12)%2C len: 311 aa. Conserved hypothetical ala-rich protein%2C highly similar to N-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 hypothetical 73.6 KDA protein from Mycobacterium tuberculosis (721 aa)%2C FASTA scores: opt: 592%2C E(): 2.7e-22%2C (37.15%25 identity in 280 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3900c;product=Conserved hypothetical alanine rich protein;protein_id=CCP46729.1;transl_table=11
AL123456.3	EMBL	gene	4386365	4386814	.	-	.	ID=gene-Rv3901c;Name=Rv3901c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3901c
AL123456.3	EMBL	CDS	4386365	4386814	.	-	0	ID=cds-CCP46730.1;Parent=gene-Rv3901c;Dbxref=EnsemblGenomes-Gn:Rv3901c,EnsemblGenomes-Tr:CCP46730,GOA:O05444,UniProtKB/TrEMBL:O05444,NCBI_GP:CCP46730.1;Name=CCP46730.1;Note=Rv3901c%2C (MTCY15F10.11)%2C len: 149 aa. Possible membrane protein (hydrophobic stretch from ~~30-52)%2C showing some similarity with O53200|Rv2473|MTV008.29 hypothetical 25.1 KDA protein from Mycobacterium tuberculosis (238 aa)%2CFASTA scores: opt: 147%2C E(): 0.036%2C (31.35%25 identity in 134 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al.%2C 2007).;gbkey=CDS;locus_tag=Rv3901c;product=Possible membrane protein;protein_id=CCP46730.1;transl_table=11
AL123456.3	EMBL	gene	4387365	4387895	.	-	.	ID=gene-Rv3902c;Name=Rv3902c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3902c
AL123456.3	EMBL	CDS	4387365	4387895	.	-	0	ID=cds-CCP46731.1;Parent=gene-Rv3902c;Dbxref=EnsemblGenomes-Gn:Rv3902c,EnsemblGenomes-Tr:CCP46731,InterPro:IPR028953,UniProtKB/TrEMBL:O05443,NCBI_GP:CCP46731.1;Name=CCP46731.1;Note=Rv3902c%2C (MTCY15F10.10)%2C len: 176 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.%2C2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3902c;product=Hypothetical protein;protein_id=CCP46731.1;transl_table=11
AL123456.3	EMBL	gene	4387892	4390432	.	-	.	ID=gene-Rv3903c;Name=Rv3903c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3903c
AL123456.3	EMBL	CDS	4387892	4390432	.	-	0	ID=cds-CCP46732.1;Parent=gene-Rv3903c;Dbxref=EnsemblGenomes-Gn:Rv3903c,EnsemblGenomes-Tr:CCP46732,GOA:O05442,InterPro:IPR025331,UniProtKB/TrEMBL:O05442,NCBI_GP:CCP46732.1;Name=CCP46732.1;Note=Rv3903c%2C (MTCY15F10.08)%2C len: 846 aa. Hypothetical unknown ala-%2C pro-rich protein.;gbkey=CDS;locus_tag=Rv3903c;product=Hypothetical alanine and proline rich protein;protein_id=CCP46732.1;transl_table=11
AL123456.3	EMBL	gene	4390437	4390709	.	-	.	ID=gene-Rv3904c;Name=esxE;gbkey=Gene;gene=esxE;gene_biotype=protein_coding;gene_synonym=ES6_12;locus_tag=Rv3904c
AL123456.3	EMBL	CDS	4390437	4390709	.	-	0	ID=cds-CCP46733.1;Parent=gene-Rv3904c;Dbxref=EnsemblGenomes-Gn:Rv3904c,EnsemblGenomes-Tr:CCP46733,InterPro:IPR010310,NCBI_GP:CCP46733.1;Name=CCP46733.1;Note=Rv3904c%2C (MT4023%2C MTCY15F10.07)%2C len: 90 aa. EsxE%2CESAT-6 like protein%2C hypothetical unknown ala-rich protein. Belongs to the ESAT6 family (see citation below).;gbkey=CDS;gene=esxE;locus_tag=Rv3904c;product=Putative ESAT-6 like protein EsxE (hypothetical alanine rich protein) (ESAT-6 like protein 12);protein_id=CCP46733.1;transl_table=11
AL123456.3	EMBL	gene	4390720	4391031	.	-	.	ID=gene-Rv3905c;Name=esxF;gbkey=Gene;gene=esxF;gene_biotype=protein_coding;gene_synonym=ES6_13;locus_tag=Rv3905c
AL123456.3	EMBL	CDS	4390720	4391031	.	-	0	ID=cds-CCP46734.1;Parent=gene-Rv3905c;Dbxref=EnsemblGenomes-Gn:Rv3905c,EnsemblGenomes-Tr:CCP46734,InterPro:IPR010310,NCBI_GP:CCP46734.1;Name=CCP46734.1;Note=Rv3905c%2C (MT4024%2C MTCY15F10.06)%2C len: 103 aa. EsxF%2CESAT-6 like protein (see citation below)%2C hypothetical unknown ala-%2C gly-rich protein%2C ESAT-6 like protein. Belongs to the ESAT6 family.;gbkey=CDS;gene=esxF;locus_tag=Rv3905c;product=Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13);protein_id=CCP46734.1;transl_table=11
AL123456.3	EMBL	gene	4391097	4391606	.	-	.	ID=gene-Rv3906c;Name=Rv3906c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3906c
AL123456.3	EMBL	CDS	4391097	4391606	.	-	0	ID=cds-CCP46735.1;Parent=gene-Rv3906c;Dbxref=EnsemblGenomes-Gn:Rv3906c,EnsemblGenomes-Tr:CCP46735,GOA:O05439,InterPro:IPR028974,UniProtKB/TrEMBL:O05439,NCBI_GP:CCP46735.1;Name=CCP46735.1;Note=Rv3906c%2C (MTCY15F10.05)%2C len: 169 aa. Conserved hypothetical protein%2C strongly related to Q50578|AT9S (sod related in Escherichia coli) from Mycobacterium tuberculosis strain aoyama B (155 aa)%2C but apparently different as flanking sequences differ and shorter 43 aa%2CFASTA scores: opt: 548%2C E(): 1.3e-26%2C (79.4%25 identity in 102 aa overlap). Selfmarch results suggest that Rv3906c is not related to any other hypothetical protein from Mycobacterium tuberculosis strain H37Rv except itself. Shows also similarity with Q9VFR2|CG9297 hypothetical protein from Drosophila melanogaster (Fruit fly) (930 aa)%2CFASTA scores: opt: 221%2C E(): 4.9e-06%2C (36.95%25 identity in 157 aa overlap)%3B Q9HQ55|CBP|VNG1320G calcium-binding protein homology from Halobacterium sp. strain NRC-1 (385 aa) FASTA scores: opt: 143%2C E(): 0.13%2C (35.65%25 identity in 160 aa overlap)%3B Q24795 calcium-binding protein (fragment) from Echinococcus granulosus (338 aa)%2C FASTA scores: opt: 140%2C E(): 0.17%2C (33.95%25 identity in 156 aa overlap).;gbkey=CDS;locus_tag=Rv3906c;product=Conserved hypothetical protein;protein_id=CCP46735.1;transl_table=11
AL123456.3	EMBL	gene	4391631	4393073	.	-	.	ID=gene-Rv3907c;Name=pcnA;gbkey=Gene;gene=pcnA;gene_biotype=protein_coding;locus_tag=Rv3907c
AL123456.3	EMBL	CDS	4391631	4393073	.	-	0	ID=cds-CCP46736.1;Parent=gene-Rv3907c;Dbxref=EnsemblGenomes-Gn:Rv3907c,EnsemblGenomes-Tr:CCP46736,GOA:L7N672,InterPro:IPR002646,InterPro:IPR003607,InterPro:IPR006674,InterPro:IPR006675,InterPro:IPR014065,UniProtKB/TrEMBL:L7N672,NCBI_GP:CCP46736.1;Name=CCP46736.1;Note=Rv3907c%2C (MTCY15F10.04)%2C len: 480 aa. Probable pcnA%2Cpolynucleotide polymerase%2C equivalent to Q9CCY1|PCNA|ML2697 PCNA protein from Mycobacterium leprae (486 aa)%2C FASTA scores: opt: 2713%2C E(): 4.3e-160%2C (84.1%25 identity in 478 aa overlap)%3B and Q59534|PCNB POLYA polymerase from Mycobacterium leprae (411 aa) FASTA scores: opt: 2077%2C E(): 7.1e-121%2C (82.55%25 identity in 373 aa overlap). Also highly similar to many e.g. Q9X8T2|SCH24.18 putative RNA nucleotidyltransferase from Streptomyces coelicolor (483 aa)%2C FASTA scores: opt: 1856%2C E(): 3.7e-107%2C (61.55%25 identity in 455 aa overlap)%3B Q9ZN65 POLYA polymerase from Prevotella ruminicola (Bacteroides ruminicola) (479 aa)%2CFASTA scores: opt: 830%2C E(): 8.5e-44%2C (34.85%25 identity in 445 aa overlap)%3B P42977|PAPS_BACSU poly(A) polymerase from Bacillus subtilis (397 aa)%2C FASTA scores: opt: 479%2C E(): 3.5e-22%2C (29.35%25 identity in 450 aa overlap)%3B etc. Contains: PS00017 ATP/GTP-binding site motif A (P-loop)%2CPS00018 EF-hand calcium-binding domain%2C and probably less significant a PS00237 G-protein coupled receptor signature%2Cand PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. Belongs to the tRNA nucleotidyltransferase / poly(A) polymerase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=pcnA;inference=protein motif:PROSITE:PS00639;locus_tag=Rv3907c;product=Probable poly(A) polymerase PcnA (polynucleotide adenylyltransferase) (NTP polymerase) (RNA adenylating enzyme) (poly(A) polymerase);protein_id=CCP46736.1;transl_table=11
AL123456.3	EMBL	gene	4393449	4394195	.	+	.	ID=gene-Rv3908;Name=mutT4;gbkey=Gene;gene=mutT4;gene_biotype=protein_coding;locus_tag=Rv3908
AL123456.3	EMBL	CDS	4393449	4394195	.	+	0	ID=cds-CCP46737.1;Parent=gene-Rv3908;Dbxref=EnsemblGenomes-Gn:Rv3908,EnsemblGenomes-Tr:CCP46737,GOA:P9WIX7,InterPro:IPR000086,InterPro:IPR015797,InterPro:IPR020084,InterPro:IPR020476,NCBI_GP:CCP46737.1;Name=CCP46737.1;Note=Rv3908%2C (MTCY15F10.03c)%2C len: 248 aa. Possible mutT4%2C mutator protein%2C equivalent to Q50195|ML2698|L222-ORF6 hypothetical protein from Mycobacterium leprae (251 aa)%2C FASTA scores: opt: 1270%2CE(): 3.4e-62%2C (79.05%25 identity in 248 aa overlap). Also similar to O66548|APFA|AQ_158 hydrolase from Aquifex aeolicus (134 aa)%2C FASTA scores: opt: 300%2C E(): 1.1e-09%2C(37.3%25 identity in 142 aa overlap)%3B and similarity with other various proteins e.g. O93721 diadenosine 5'5'''-P1%2CP4-tetraphosphate pyrophosphohydrolase from Pyrobaculum aerophilum (143 aa)%2C FASTA scores: opt: 205%2CE(): 0.00017%2C (34.85%25 identity in 109 aa overlap)%3B Q9HS29|APA|VNG0431G diadenosine tetraphosphate pyrophosphohydrolase from Halobacterium sp. strain NRC-1 (142 aa)%2C FASTA scores: opt: 199%2C E(): 0.00036%2C (34.0%25 identity in 147 aa overlap)%3B Q9YA58|APE2080 hypothetical 19.2 KDA protein from Aeropyrum pernix (175 aa) FASTA scores: opt: 191%2C E(): 0.0012%2C (36.9%25 identity in 141 aa overlap)%3B etc. Also similar to P95110|MUTT1|Rv2985|MTCY349.02 hypothetical 34.7 KDA protein from Mycobacterium tuberculosis (317 aa) FASTA scores: opt: 224%2C E(): 3e-05%2C (34.05%25 identity in 144 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008). Seems to belong to the NUDIX hydrolase family.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=mutT4;inference=protein motif:PROSITE:PS00893;locus_tag=Rv3908;product=Possible mutator protein MutT4;protein_id=CCP46737.1;transl_table=11
AL123456.3	EMBL	gene	4394192	4396600	.	+	.	ID=gene-Rv3909;Name=Rv3909;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3909
AL123456.3	EMBL	CDS	4394192	4396600	.	+	0	ID=cds-CCP46738.1;Parent=gene-Rv3909;Dbxref=EnsemblGenomes-Gn:Rv3909,EnsemblGenomes-Tr:CCP46738,GOA:O05436,UniProtKB/TrEMBL:O05436,NCBI_GP:CCP46738.1;Name=CCP46738.1;Note=Rv3909%2C (MTCY15F10.02c)%2C len: 802 aa. Conserved protein%2C equivalent to Q9CCY0|ML2699 putative secreted protein from Mycobacterium leprae (797 aa) FASTA scores: opt: 3777%2C E(): 8.8e-206%2C (72.35%25 identity in 803 aa overlap). Note that the N-terminal end is highly similar to Q50196|L222-ORF7 (286 aa)%2C FASTA scores: opt: 1213%2C E(): 2.7e-61%2C (71.75%25 identity in 255 aa overlap)%3B and the C-terminal end is highly similar to Q50197|L222-ORF8 also from Mycobacterium leprae (512 aa) FASTA scores: opt: 2375%2CE(): 9.9e-127%2C (71.8%25 identity in 518 aa overlap). Shows some similarity with N-terminal end of Q9I2M3|PA1874 hypothetical protein from Pseudomonas aeruginosa (2468 aa)%2CFASTA scores: opt: 171%2C E(): 0.13%2C (22.9%25 identity in 672 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C 2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3909;product=Conserved protein;protein_id=CCP46738.1;transl_table=11
AL123456.3	EMBL	gene	4396597	4400151	.	+	.	ID=gene-Rv3910;Name=Rv3910;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3910
AL123456.3	EMBL	CDS	4396597	4400151	.	+	0	ID=cds-CCP46739.1;Parent=gene-Rv3910;Dbxref=EnsemblGenomes-Gn:Rv3910,EnsemblGenomes-Tr:CCP46739,GOA:P9WJK3,InterPro:IPR004268,InterPro:IPR008979,InterPro:IPR011009,PDB:3OTV,PDB:3OUK,PDB:3OUN,PDB:3UQC,NCBI_GP:CCP46739.1;Name=CCP46739.1;Note=Rv3910%2C (MTCY15F10.01c.MTV028.01)%2C len: 1184 aa. Probable conserved transmembrane protein (hydrophobic domain ~~50-550)%2C equivalent to Q9CCX9|ML2700 possible conserved membrane protein from Mycobacterium leprae (1206 aa)%2C FASTA scores: opt: 5554%2C E(): 0%2C (75.15%25 identity in 1182 aa overlap)%3B and highly similar%2C but shorter 380 aa%2Cto Q50199|L222-ORF10 from Mycobacterium leprae (784 aa) FASTA scores: opt: 3297%2C E(): 5.5e-170%2C (68.8%25 identity in 769 aa overlap)%3B and at the N-terminal end with Q50198|L222-ORF also from Mycobacterium leprae (379 aa) FASTA scores: opt: 1955%2C E(): 5.7e-98%2C (88.4%25 identity in 353 aa overlap) (ORFs 9 and 10 are adjacent on L222). Also similar in part (principally at the N-terminal end) to other membrane proteins e.g. Q9X8T0|SCH24.16c putative transmembrane protein from Streptomyces coelicolor (811 aa)%2C FASTA scores: opt: 573%2C E(): 2.8e-23%2C (31.05%25 identity in 573 aa overlap)%3B O05467|MVIN_RHITR integral membrane protein virulence factor MVIN homolog from Rhizobium tropici (533 aa)%2C FASTA scores: opt: 468%2C E(): 9e-18%2C(27.1%25 identity in 524 aa overlap)%3B P56882|MVIN_RHIME integral membrane protein virulence factor MVIN homolog from Rhizobium meliloti (Sinorhizobium meliloti) (535 aa)%2CFASTA scores: opt: 453%2C E(): 5.8e-17%2C (26.2%25 identity in 557 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3910;product=Probable conserved transmembrane protein;protein_id=CCP46739.1;transl_table=11
AL123456.3	EMBL	gene	4400186	4400854	.	+	.	ID=gene-Rv3911;Name=sigM;gbkey=Gene;gene=sigM;gene_biotype=protein_coding;locus_tag=Rv3911
AL123456.3	EMBL	CDS	4400186	4400854	.	+	0	ID=cds-CCP46740.1;Parent=gene-Rv3911;Dbxref=EnsemblGenomes-Gn:Rv3911,EnsemblGenomes-Tr:CCP46740,GOA:O53590,InterPro:IPR007627,InterPro:IPR011991,InterPro:IPR013249,InterPro:IPR013324,InterPro:IPR013325,InterPro:IPR014284,NCBI_GP:CCP46740.1;Name=CCP46740.1;Note=Rv3911%2C (MTV028.02)%2C len: 222 aa. Possible sigM%2Calternative RNA polymerase sigma factor (see Gomez et al.%2C1997%3B Chen et al.%2C 2000)%2C highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) putative RNA polymerase sigma factor from Streptomyces coelicolor (236 aa)%2C FASTA scores: opt: 336%2C E(): 2.8e-13%2C (41.5%25 identity in 212 aa overlap)%3B Q98KG8|MLR1481 probable RNA polymerase sigma subunit from Rhizobium loti (Mesorhizobium loti) (307 aa)%2C FASTA scores: opt: 221%2C E(): 2.9e-06%2C (32.95%25 identity in 179 aa overlap)%3B Q9A4S9|CC2751 putative RNA polymerase sigma factor from Caulobacter crescentus (186 aa)%2C FASTA scores: opt: 217%2C E(): 3.3e-06%2C (36.95%25 identity in 138 aa overlap)%3B etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 putative RNA polymerase sigma factor from Mycobacterium tuberculosis (257 aa)%2C FASTA scores: opt: 193%2C E(): 0.00012%2C (33.15%25 identity in 163 aa overlap)%3B and O05735|SIGE putative RNA polymerase sigma factor from Mycobacterium avium (251 aa)%2CFASTA scores: opt: 192%2C E(): 0.00014%2C (33.15%25 identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA polymerase sigma-70 factor from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. Belongs to the sigma-70 factor family%2C ECF subfamily.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=sigM;locus_tag=Rv3911;product=Possible alternative RNA polymerase sigma factor SigM;protein_id=CCP46740.1;transl_table=11
AL123456.3	EMBL	gene	4400870	4401634	.	+	.	ID=gene-Rv3912;Name=Rv3912;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3912
AL123456.3	EMBL	CDS	4400870	4401634	.	+	0	ID=cds-CCP46741.1;Parent=gene-Rv3912;Dbxref=EnsemblGenomes-Gn:Rv3912,EnsemblGenomes-Tr:CCP46741,GOA:P9WJ65,NCBI_GP:CCP46741.1;Name=CCP46741.1;Note=Rv3912%2C (MTV008.03)%2C len: 254 aa. Hypothetical unknown ala-rich protein. Cleaved by Rip|Rv2869c%2C in M. tuberculosis Erdman (See Sklar et al.%2C 2010).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3912;product=Hypothetical alanine rich protein;protein_id=CCP46741.1;transl_table=11
AL123456.3	EMBL	gene	4401728	4402735	.	+	.	ID=gene-Rv3913;Name=trxB2;gbkey=Gene;gene=trxB2;gene_biotype=protein_coding;gene_synonym=trxR;locus_tag=Rv3913
AL123456.3	EMBL	CDS	4401728	4402735	.	+	0	ID=cds-CCP46742.1;Parent=gene-Rv3913;Dbxref=EnsemblGenomes-Gn:Rv3913,EnsemblGenomes-Tr:CCP46742,GOA:P9WHH1,InterPro:IPR000103,InterPro:IPR001327,InterPro:IPR005982,InterPro:IPR008255,InterPro:IPR013027,InterPro:IPR023753,PDB:2A87,NCBI_GP:CCP46742.1;Name=CCP46742.1;Note=Rv3913%2C (MT4032%2C MTV028.04)%2C len: 335 aa. Probable trxB2%2C thioredoxin reductase (see citation below)%2Cequivalent to O30973|TRXB_MYCSM thioredoxin reductase from Mycobacterium smegmatis (311 aa)%2C FASTA scores: opt: 1575%2CE(): 1.8e-87%2C (78.35%25 identity in 305 aa overlap)%3B and highly similar%2C but shorter at C-terminus%2C to P46843|TRXB_MYCLE|TRXB/a|TRX|ML2703 bifunctional thioredoxin reductase/thioredoxin from Mycobacterium leprae (458 aa)%2C FASTA scores: opt: 1766%2C E(): 8.7e-99%2C (83.25%25 identity in 328 aa overlap). Also highly similar to many e.g. P52215|TRXB_STRCO|SCH24.12 from Streptomyces coelicolor (321 aa)%2C FASTA scores: opt: 1249%2C E(): 7.2e-68%2C(60.4%25 identity in 313 aa overlap)%3B Q9Z8M4|TRXB_CHLPN from Chlamydia pneumoniae (Chlamydophila pneumoniae) (311 aa)%2CFASTA scores: opt: 978%2C E(): 1.3e-51%2C (49.85%25 identity in 307 aa overlap)%3B P09625|TRXB_ECOLI|B0888 from Escherichia coli strain K12 (320 aa)%2C FASTA scores: opt: 948%2C E(): 8.6e-50%2C (49.2%25 identity in 309 aa overlap)%3B etc. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Belongs to the pyridine nucleotide-disulfide oxidoreductases class-II. Cofactor: FAD (by similarity).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trxB2;inference=protein motif:PROSITE:PS00573;locus_tag=Rv3913;product=Probable thioredoxin reductase TrxB2 (TRXR) (TR);protein_id=CCP46742.1;transl_table=11
AL123456.3	EMBL	gene	4402732	4403082	.	+	.	ID=gene-Rv3914;Name=trxC;gbkey=Gene;gene=trxC;gene_biotype=protein_coding;gene_synonym=mpt46,trx,trxA;locus_tag=Rv3914
AL123456.3	EMBL	CDS	4402732	4403082	.	+	0	ID=cds-CCP46743.1;Parent=gene-Rv3914;Dbxref=EnsemblGenomes-Gn:Rv3914,EnsemblGenomes-Tr:CCP46743,GOA:P9WG67,InterPro:IPR005746,InterPro:IPR012336,InterPro:IPR013766,InterPro:IPR017937,PDB:2I1U,PDB:2L4Q,PDB:2L59,PDB:3O6T,NCBI_GP:CCP46743.1;Name=CCP46743.1;Note=Rv3914%2C (MT4033%2C MTV028.05)%2C len: 116 aa. TrxC (alternate gene names: mpt46%2C trx%2C trxA *)%2C thioredoxin (see citations below)%2C equivalent to O30974|THIO_MYCSM|TRXA thioredoxin from Mycobacterium smegmatis (112 aa)%2C FASTA scores: opt: 576%2C E(): 2.1e-32%2C (80.2%25 identity in 111 aa overlap)%3B and also equivalent to C-terminal end of P46843|TRXB_MYCLE|TRXB/a|TRX|ML2703 bifunctional thioredoxin reductase/thioredoxin from Mycobacterium leprae (458 aa)%2C FASTA scores: opt: 628%2C E(): E(): 2e-35%2C (82.9%25 identity in 117 aa overlap). Also highly similar to many e.g. P80579|THIO_ALIAC from Alicyclobacillus acidocaldarius (Bacillus acidocaldarius) (105 aa)%2C FASTA scores: opt: 411%2CE(): 3e-21%2C (57.15%25 identity in 105 aa overlap)%3B P00275|THI1_CORNE from Corynebacterium nephridii (105 aa)%2CFASTA scores: opt: 394%2C E(): 4.3e-20%2C (56.7%25 identity in 97 aa overlap)%3B P00274|THIO_ECOLI|TRXA|TSNC|FIPA|B3781 from Escherichia coli and Salmonella typhimurium strain K12 and LT2 respectively (108 aa)%2C FASTA scores: opt: 364%2C E(): 4.7e-18%2C (54.45%25 identity in 101 aa overlap)%3B etc. Also similar to O53162|TRXB|Rv1471|MTV007.18 thioredoxin from Mycobacterium tuberculosis (123 aa)%2C FASTA scores: E(): 2.3e-15%2C (41.9%25 identity in 93 aa overlap). Contains PS00194 Thioredoxin family active site. Belongs to the thioredoxin family. The product of this CDS is supposedly secreted. In this case%2C this protein could exert its free radical scavenging activity inside macrophages. (*) Warning: note that Rv1470|MTV007.17 correspond also to trxA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=trxC;inference=protein motif:PROSITE:PS00194;locus_tag=Rv3914;product=Thioredoxin TrxC (TRX) (MPT46);protein_id=CCP46743.1;transl_table=11
AL123456.3	EMBL	gene	4403192	4404412	.	+	.	ID=gene-Rv3915;Name=Rv3915;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3915
AL123456.3	EMBL	CDS	4403192	4404412	.	+	0	ID=cds-CCP46744.1;Parent=gene-Rv3915;Dbxref=EnsemblGenomes-Gn:Rv3915,EnsemblGenomes-Tr:CCP46744,GOA:L7N653,InterPro:IPR002477,InterPro:IPR002508,UniProtKB/TrEMBL:L7N653,NCBI_GP:CCP46744.1;Name=CCP46744.1;Note=Rv3915%2C (MTV028.06)%2C len: 406 aa. Probable peptidoglycan hydrolase%2C equivalent to Q9CCX8|ML2704 putative hydrolase from Mycobacterium leprae (406 aa) FASTA scores: opt: 2341%2C E(): 2.7e-138%2C (86.95%25 identity in 406 aa overlap)%3B the N-terminal end is highly similar to Q59535 N-acetymuramyl-L-alanine amidase from Mycobacterium leprae (205 aa)%2C FASTA scores: opt: 1046%2C E(): 5.7e-58%2C (84.85%25 identity in 185 aa overlap). Also similar to other hydrolases (especially amidases) e.g. C-terminal end of Q9K6R3|LYTC|BH3665 N-acetylmuramoyl-L-alanine amidase (major autolysin) from Bacillus halodurans (588 aa)%2C FASTA scores: opt: 363%2C E(): 4.3e-15%2C (33.15%25 identity in 356 aa overlap)%3B Q9PKC7|TC0539 putative N-acetylmuramoyl-L-alanine amidase from Chlamydia muridarum (268 aa)%2C FASTA scores: opt: 285%2C E(): 1.6e-10%2C (26.05%25 identity in 242 aa overlap) (RV3915 product appears longer 127 aa)%3B Q9S596|PDCA penicillin-resistant DD-carboxypeptidase from Myxococcus xanthus (302 aa)%2C FASTA scores: opt: 270%2C E(): 1.5e-09%2C(39.85%25 identity in 158 aa overlap)%3B etc. Note that previously known as cwlM. Conserved in M. tuberculosis%2C M. leprae%2C M. bovis and M. avium paratuberculosis%3B predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani%2C 2007).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3915;product=Probable peptidoglycan hydrolase;protein_id=CCP46744.1;transl_table=11
AL123456.3	EMBL	gene	4404433	4405167	.	-	.	ID=gene-Rv3916c;Name=Rv3916c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3916c
AL123456.3	EMBL	CDS	4404433	4405167	.	-	0	ID=cds-CCP46745.1;Parent=gene-Rv3916c;Dbxref=EnsemblGenomes-Gn:Rv3916c,EnsemblGenomes-Tr:CCP46745,GOA:O53594,UniProtKB/TrEMBL:O53594,NCBI_GP:CCP46745.1;Name=CCP46745.1;Note=Rv3916c%2C (MTV028.07c)%2C len: 244 aa. Conserved hypothetical protein%2C equivalent to Q50200|ML2705|L222-ORF1 hypothetical protein from Mycobacterium leprae (259 aa)%2CFASTA scores: opt: 1266%2C E(): 2e-74%2C (76.4%25 identity in 250 aa overlap). Also highly similar (but with gaps) to Q9R3S2|STH24.10 hypothetical 22.6 KDA protein from Streptomyces coelicolor (205 aa)%2C FASTA scores: opt: 387%2CE(): 7.5e-18%2C (40.25%25 identity in 231 aa overlap). Predicted to be an outer membrane protein (See Song et al.%2C2008).;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3916c;product=Conserved hypothetical protein;protein_id=CCP46745.1;transl_table=11
AL123456.3	EMBL	gene	4405457	4406491	.	-	.	ID=gene-Rv3917c;Name=parB;gbkey=Gene;gene=parB;gene_biotype=protein_coding;gene_synonym=parA;locus_tag=Rv3917c
AL123456.3	EMBL	CDS	4405457	4406491	.	-	0	ID=cds-CCP46746.1;Parent=gene-Rv3917c;Dbxref=EnsemblGenomes-Gn:Rv3917c,EnsemblGenomes-Tr:CCP46746,GOA:P9WIJ9,InterPro:IPR003115,InterPro:IPR004437,InterPro:IPR013741,NCBI_GP:CCP46746.1;Name=CCP46746.1;Note=Rv3917c%2C (MTV028.08c%2C MT4036)%2C len: 344 aa. Probable parB%2C chromosome partitioning protein%2C equivalent to Q50201|PARB_MYCLE|ML2706 probable chromosome partitioning protein from Mycobacterium leprae (333 aa)%2C FASTA scores: opt: 1654%2C E(): 1.6e-88%2C (78.6%25 identity in 332 aa overlap). Also highly similar to to others e.g. Q9S6U1|STH24.09 putative partitioning or sporulation protein from Streptomyces coelicolor (328 aa)%2C FASTA scores: opt: 966%2C E(): 9.7e-49%2C (58.55%25 identity in 287 aa overlap) (no similarity on N-terminus)%3B Q9PB63|PARB_XYLFA|XF2281 probable chromosome partitioning protein from Xylella fastidiosa (310 aa)%2C FASTA scores: opt: 598%2C E(): 1.8e-27%2C (38.65%25 identity in 326 aa overlap)%3B P31857|PARB_PSEPU probable chromosome partitioning protein from Pseudomonas putida (290 aa)%2CFASTA scores: opt: 573%2C E(): 4.6e-26%2C (40.35%25 identity in 322 aa overlap)%3B etc. Contains probable helix-turn-helix motif at aa 179 to 200 (Score 1150%2C +3.1 0 SD). Belongs to the ParB family. Note that previously known as parA.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=parB;locus_tag=Rv3917c;product=Probable chromosome partitioning protein ParB;protein_id=CCP46746.1;transl_table=11
AL123456.3	EMBL	gene	4406488	4407531	.	-	.	ID=gene-Rv3918c;Name=parA;gbkey=Gene;gene=parA;gene_biotype=protein_coding;gene_synonym=parB;locus_tag=Rv3918c
AL123456.3	EMBL	CDS	4406488	4407531	.	-	0	ID=cds-CCP46747.1;Parent=gene-Rv3918c;Dbxref=EnsemblGenomes-Gn:Rv3918c,EnsemblGenomes-Tr:CCP46747,GOA:Q1LVD4,InterPro:IPR002586,InterPro:IPR027417,UniProtKB/TrEMBL:Q1LVD4,NCBI_GP:CCP46747.1;Name=CCP46747.1;Note=Rv3918c%2C (MTV028.09c)%2C len: 347 aa. Probable parA%2Cchromosome partitioning protein%2C highly similar to Q9CCX7|para|ML2707 putative cell division protein from Mycobacterium leprae (351 aa)%2C FASTA scores: opt: 1679%2CE(): 2.9e-93%2C (78.1%25 identity in 347 aa overlap). Also highly similar to others e.g. Q9RFM1|para para protein from Streptomyces coelicolor (357 aa)%2C FASTA scores: opt: 1197%2CE(): 2e-64%2C (60.45%25 identity in 306 aa overlap)%3B Q98DZ3|MLL4479|para chromosome partitioning protein from Rhizobium loti (Mesorhizobium loti) (266 aa)%2C FASTA scores: opt: 835%2C E(): 7.2e-43%2C (50.95%25 identity in 257 aa overlap)%3B O05189|PARA_CAUCR chromosome partitioning protein from Caulobacter crescentus (267 aa)%2C FASTA scores: opt: 813%2C E(): 1.5e-41%2C (51.35%25 identity in 261 aa overlap) (has its N-terminus shorter)%3B etc. Equivalent to AAK48403 from Mycobacterium tuberculosis strain CDC1551 (381 aa) but shorter 34 aa. Also similar to other Mycobacterium tuberculosis proteins: MTCI125.30%2C FASTA scores: E(): 4.3e-32%2C (35.2%25 identity in 327 aa overlap)%3B and MTCY07D11.13%2C FASTA scores: E(): 3e-30%2C (39.9%25 identity in 263 aa overlap). Belongs to the para family. Possible alternative start site at aa 107. Note that previously known as parB.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=parA;locus_tag=Rv3918c;product=Probable chromosome partitioning protein ParA;protein_id=CCP46747.1;transl_table=11
AL123456.3	EMBL	gene	4407528	4408202	.	-	.	ID=gene-Rv3919c;Name=gid;gbkey=Gene;gene=gid;gene_biotype=protein_coding;gene_synonym=gidB;locus_tag=Rv3919c
AL123456.3	EMBL	CDS	4407528	4408202	.	-	0	ID=cds-CCP46748.1;Parent=gene-Rv3919c;Dbxref=EnsemblGenomes-Gn:Rv3919c,EnsemblGenomes-Tr:CCP46748,GOA:P9WGW9,InterPro:IPR003682,InterPro:IPR029063,NCBI_GP:CCP46748.1;Name=CCP46748.1;Note=Rv3919c%2C (MT4038%2C MTV028.10c)%2C len: 224 aa. Probable gid (alternate gene name: gidB)%2C glucose-inhibited division protein B%2C equivalent%2C but shorter 20 aa%2C to Q9L7M3 putative GIDB (fragment) from Mycobacterium paratuberculosis (245 aa)%2C FASTA scores: opt: 1018%2C E(): 4.8e-57%2C (73.95%25 identity in 211 aa overlap)%3B and Q50203|GIDB_MYCLE|ML2708 glucose inhibited division protein B from Mycobacterium leprae (245 aa)%2C FASTA scores: opt: 966%2C E(): 9.1e-54%2C (68.4%25 identity in 212 aa overlap). Also highly similar to many e.g. O54571|GIDB_STRCO|STH24.07 from Streptomyces coelicolor (239 aa)%2C FASTA scores: opt: 654%2CE(): 3.9e-34%2C (47.95%25 identity in 221 aa overlap)%3B Q9KNG5|VC2774 from Vibrio cholerae (210 aa)%2C FASTA scores: opt: 300%2C E(): 6.9e-12%2C (38.15%25 identity in 139 aa overlap)%3B P17113|GIDB_ECOLI|B3740|Z5240|ECS4682 from Escherichia coli (several strains) (207 aa)%2C FASTA scores: opt: 287%2C E(): 4.5e-11%2C (34.8%25 identity in 138 aa overlap)%3B etc. Contains PS00539 Pyrokinins signature. Belongs to the GIDB family. Nucleotide position 4407904 in the genome sequence has been corrected%2C G:A resulting in S100F.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;gene=gid;inference=protein motif:PROSITE:PS00539;locus_tag=Rv3919c;product=Probable glucose-inhibited division protein B Gid;protein_id=CCP46748.1;transl_table=11
AL123456.3	EMBL	gene	4408334	4408897	.	-	.	ID=gene-Rv3920c;Name=Rv3920c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3920c
AL123456.3	EMBL	CDS	4408334	4408897	.	-	0	ID=cds-CCP46749.1;Parent=gene-Rv3920c;Dbxref=EnsemblGenomes-Gn:Rv3920c,EnsemblGenomes-Tr:CCP46749,GOA:O53598,InterPro:IPR001374,UniProtKB/TrEMBL:O53598,NCBI_GP:CCP46749.1;Name=CCP46749.1;Note=Rv3920c%2C (MTV028.11c)%2C len: 187 aa. Conserved protein%2C similar to jag protein%2C equivalent to Q9L7M2 hypothetical 20.1 KDA protein from Mycobacterium paratuberculosis (183 aa)%2C FASTA scores: opt: 1004%2C E(): 7.3e-52%2C (85.05%25 identity in 187 aa overlap)%3B and Q50204|ML2709 hypothetical protein similar to jag protein SPOIIIJ associated protein in bacillus subtilis from Mycobacterium leprae (193 aa)%2C FASTA scores: opt: 871%2C E(): 4.4e-44%2C (73.05%25 identity in 193 aa overlap). Also similar to other bacterial proteins e.g. O54595|STH24.06|jag jag-like protein from Streptomyces coelicolor (170 aa)%2CFASTA scores: opt: 593%2C E(): 6.7e-28%2C (62.85%25 identity in 167 aa overlap)%3B Q9RCA6|jag|BH4063 jag protein homolog from Bacillus halodurans (207 aa)%2C FASTA scores: opt: 282%2C E(): 1.1e-09%2C (35.0%25 identity in 140 aa overlap)%3B Q9X1H1|TM1460 putative jag protein%2C putative from Thermotoga maritima (221 aa)%2C FASTA scores: opt: 258%2C E(): 3e-08%2C (31.9%25 identity in 138 aa overlap)%3BQ01620|JAG_BACSU jag protein (SPOIIIJ associated protein) from Bacillus subtilis (208 aa)%2C FASTA scores: opt: 196%2C E(): 0.00012%2C (28.05%25 identity in 139 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3920c;product=Conserved protein similar to jag protein;protein_id=CCP46749.1;transl_table=11
AL123456.3	EMBL	gene	4408969	4410069	.	-	.	ID=gene-Rv3921c;Name=Rv3921c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3921c
AL123456.3	EMBL	CDS	4408969	4410069	.	-	0	ID=cds-CCP46750.1;Parent=gene-Rv3921c;Dbxref=EnsemblGenomes-Gn:Rv3921c,EnsemblGenomes-Tr:CCP46750,GOA:P9WIT5,InterPro:IPR001708,InterPro:IPR028055,NCBI_GP:CCP46750.1;Name=CCP46750.1;Note=Rv3921c%2C (MTV028.12c)%2C len: 366 aa. Probable conserved transmembrane protein%2C equivalent to Q9L7M1 hypothetical 39.2 KDA protein from Mycobacterium paratuberculosis (353 aa)%2C FASTA scores: opt: 2001%2C E(): 8.4e-100%2C (83.05%25 identity in 366 aa overlap)%3B Q9CCX6|ML2710 putative conserved membrane protein from Mycobacterium leprae (380 aa)%2C FASTA scores: opt: 1929%2CE(): 6.2e-96%2C (77.1%25 identity in 380 aa overlap)%3B Q50205 CDS 27 on L222 from Mycobacterium leprae (312 aa) FASTA scores: opt: 1770%2C E(): 1.6e-87%2C (88.2%25 identity in 288 aa overlap). Also similar to other e.g. O54569|STH24.05 inner membrane protein. from Streptomyces coelicolor (431 aa)%2CFASTA scores: opt: 412%2C E(): 6.5e-15%2C (33.45%25 identity in 266 aa overlap)%3B O84253|CT251 60 KDA inner membrane protein from Chlamydia trachomatis (787 aa)%2C FASTA scores: opt: 304%2C E(): 6e-09%2C (27.9%25 identity in 269 aa overlap)%3B P29431|60IM_BUCAP 60 KDA inner-membrane protein homolog from Buchnera aphidicola (subsp. Schizaphis graminum) (536 aa)%2C FASTA scores: opt: 282%2C E(): 6.7e-08%2C (36.1%25 identity in 108 aa overlap)%3B etc.;experiment=EXISTENCE: identified in proteomics study;gbkey=CDS;locus_tag=Rv3921c;product=Probable conserved transmembrane protein;protein_id=CCP46750.1;transl_table=11
AL123456.3	EMBL	gene	4410053	4410415	.	-	.	ID=gene-Rv3922c;Name=Rv3922c;gbkey=Gene;gene_biotype=protein_coding;locus_tag=Rv3922c
AL123456.3	EMBL	CDS	4410053	4410415	.	-	0	ID=cds-CCP46751.1;Parent=gene-Rv3922c;Dbxref=EnsemblGenomes-Gn:Rv3922c,EnsemblGenomes-Tr:CCP46751,GOA:P9WFL9,InterPro:IPR002696,NCBI_GP:CCP46751.1;Name=CCP46751.1;Note=Rv3922c%2C (MTV028.13c)%2C len: 120 aa. Possible hemolysin%2C highly similar to Q9L7M0|YIDD_MYCPA hypothetical 12.4 KDA protein from Mycobacterium paratuberculosis (115 aa)%2C FASTA scores: opt: 521%2C E(): 1.9e-29%2C (65.2%25 identity in 112 aa overlap). Also highly similar to Q44066|HLYA_AERHY putative alpha-hemolysin from Aeromonas hydrophila (85 aa)%2C FASTA scores: opt: 276%2C E(): 1.5e-12%2C(51.45%25 identity in 70 aa overlap)%3B and to many bacterial hypothetical proteins from bacterium e.g. P22847|YIDD_ECOLI|B3704.1 hypothetical protein from Escherichia coli strain K12 (85 aa)%2C FASTA scores: opt: 276%2C E(): 1.5e-12%2C (51.45%25 identity in 70 aa overlap).;gbkey=CDS;locus_tag=Rv3922c;product=Possible hemolysin;protein_id=CCP46751.1;transl_table=11
AL123456.3	EMBL	gene	4410412	4410789	.	-	.	ID=gene-Rv3923c;Name=rnpA;gbkey=Gene;gene=rnpA;gene_biotype=protein_coding;locus_tag=Rv3923c
AL123456.3	EMBL	CDS	4410412	4410789	.	-	0	ID=cds-CCP46752.1;Parent=gene-Rv3923c;Dbxref=EnsemblGenomes-Gn:Rv3923c,EnsemblGenomes-Tr:CCP46752,GOA:P9WGZ3,InterPro:IPR000100,InterPro:IPR014721,InterPro:IPR020539,InterPro:IPR020568,NCBI_GP:CCP46752.1;Name=CCP46752.1;Note=Rv3923c%2C (MT4041%2C MTV028.14c)%2C len: 125 aa. RnpA%2Cribonuclease P protein component (see citations below)%2Cequivalent%2C but longer ~~10 aa%2C to P46610|RNPA_MYCLE|ML2712 ribonuclease P protein component from Mycobacterium leprae (120 aa)%2C FASTA scores: opt: 456%2C E(): 3.3e-24%2C (63.0%25 identity in 119 aa overlap)%3B and Q9L7L9|RNPA from Mycobacterium paratuberculosis (119 aa)%2C FASTA scores: opt: 426%2C E(): 3.5e-22%2C (60.65%25 identity in 122 aa overlap). Also similar to many e.g. P25817|RNPA_STRBI from Streptomyces bikiniensis (123 aa)%2C FASTA scores: opt: 174%2CE(): 4.2e-05%2C (36.8%25 identity in 125 aa overlap)%3B P25814|RNPA_BACSU from Bacillus subtilis (116 aa) FASTA scores: opt: 168%2C E(): 0.0001%2C (26.85%25 identity in 108 aa overlap)%3B P48206|RNPA_STRCO|STH24.03 from Streptomyces coelicolor (123 aa)%2C FASTA scores: opt: 166%2C E(): 0.00015%2C(37.6%25 identity in 125 aa overlap)%3B etc. Contains PS00648 Bacterial Ribonuclease P protein component signature. Belongs to the RnpA family.;gbkey=CDS;gene=rnpA;inference=protein motif:PROSITE:PS00648;locus_tag=Rv3923c;product=Ribonuclease P protein component RnpA (RNaseP protein) (RNase P protein) (protein C5);protein_id=CCP46752.1;transl_table=11
AL123456.3	EMBL	gene	4410786	4410929	.	-	.	ID=gene-Rv3924c;Name=rpmH;gbkey=Gene;gene=rpmH;gene_biotype=protein_coding;locus_tag=Rv3924c
AL123456.3	EMBL	CDS	4410786	4410929	.	-	0	ID=cds-CCP46753.1;Parent=gene-Rv3924c;Dbxref=EnsemblGenomes-Gn:Rv3924c,EnsemblGenomes-Tr:CCP46753,GOA:P9WH93,InterPro:IPR000271,InterPro:IPR020939,NCBI_GP:CCP46753.1;Name=CCP46753.1;Note=Rv3924c%2C (MTV028.15)%2C len: 47 aa. rpmH%2C 50s ribosomal protein l34 (see citations below)%2C equivalent to many mycobacterial 50S ribosomal protein L34 e.g. P46386|RL34_MYCLE|RPMH|ML2713 from Mycobacterium leprae (47 aa)%2C FASTA scores: opt: 287%2C E(): 8.5e-17%2C (91.5%25 identity in 47 aa overlap)%3B and Q9L7L8|RL34_MYCPA|RPMH from Mycobacterium paratuberculosis (47 aa)%2C FASTA scores: opt: 281%2C E(): 2.6e-16%2C (89.35%25 identity in 47 aa overlap). Also highly similar to other ribosomal proteins e.g. P27901|RL34_STRCO|RPMH|STH24.02 from Streptomyces coelicolor (45 aa)%2C FASTA scores: opt: 234%2C E(): 1.4e-12%2C(79.05%25 identity in 43 aa overlap)%3B and P05647|RL34_BACSU|RPMH from Bacillus subtilis (44 aa) FASTA scores: opt: 229%2C E(): 3.7e-12%2C (72.35%25 identity in 47 aa overlap)%3B etc. Contains PS00784 Ribosomal protein L34 signature. Belongs to the L34P family of ribosomal proteins.;gbkey=CDS;gene=rpmH;inference=protein motif:PROSITE:PS00784;locus_tag=Rv3924c;product=50S ribosomal protein L34 RpmH;protein_id=CCP46753.1;transl_table=11
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